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<P STYLE="font: 16pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>UNITED STATES</B></P>

<P STYLE="font: 16pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>SECURITIES AND EXCHANGE COMMISSION</B></P>

<P STYLE="font: 12pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>Washington, D.C. 20549</B></P>

<P STYLE="font: 12pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>&nbsp;</B></P>



<P STYLE="font: 12pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B></B></P>

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<P STYLE="font: 12pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: 16pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>FORM 8-K </B></P>

<P STYLE="font: 9pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&nbsp;</P>



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<P STYLE="font: 9pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in"></P>

<P STYLE="font: 9pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: 11pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>CURRENT REPORT </B></P>

<P STYLE="font: 11pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>Pursuant to Section&nbsp;13 or 15(d)
of the</B></P>

<P STYLE="font: 11pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>Securities Exchange Act of 1934</B></P>

<P STYLE="font: 11pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>&nbsp;</B></P>

<P STYLE="font: 11pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>Date of Report (Date of earliest
event reported): May 8, 2014</B></P>

<P STYLE="font: 11pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: 11pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"></P>

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<P STYLE="font: 11pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>&nbsp;</B></P>

<P STYLE="font: 16pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>SEMLER SCIENTIFIC, INC.</B></P>

<P STYLE="font: 7.5pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>(Exact name of registrant as specified
in its charter)</B></P>

<P STYLE="font: 9pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
<TR STYLE="vertical-align: bottom">
    <TD STYLE="width: 38%; text-align: center"><FONT STYLE="font-size: 10pt"><B>Delaware</B></FONT></TD>
    <TD STYLE="width: 1%; text-align: center">&nbsp;</TD>
    <TD STYLE="width: 28%; text-align: center"><FONT STYLE="font-size: 10pt"><B>001-36305</B></FONT></TD>
    <TD STYLE="width: 1%; font-size: 12pt; text-align: center">&nbsp;</TD>
    <TD STYLE="width: 32%; text-align: center"><FONT STYLE="font-size: 10pt"><B>26-1367393</B></FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: center"><FONT STYLE="font-size: 10pt">(State or other jurisdiction of<BR>
incorporation)</FONT></TD>
    <TD STYLE="text-align: center">&nbsp;</TD>
    <TD STYLE="text-align: center"><FONT STYLE="font-size: 10pt">(Commission File Number)</FONT></TD>
    <TD STYLE="font-size: 12pt; text-align: center">&nbsp;</TD>
    <TD STYLE="text-align: center"><FONT STYLE="font-size: 10pt">(IRS Employer Identification No.)</FONT></TD></TR>
<TR STYLE="vertical-align: bottom">
    <TD COLSPAN="3">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>&nbsp;</B></P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>2330 NW Everett St. </B></P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>Portland, Oregon</B></P></TD>
    <TD STYLE="font-size: 7.5pt; text-align: center">&nbsp;</TD>
    <TD STYLE="text-align: center"><FONT STYLE="font-size: 10pt"><B>97210</B></FONT></TD></TR>
<TR>
    <TD COLSPAN="3" STYLE="vertical-align: top; text-align: center"><FONT STYLE="font-size: 10pt">(Address of principal executive offices)</FONT></TD>
    <TD STYLE="vertical-align: bottom; font-size: 7.5pt">&nbsp;</TD>
    <TD STYLE="vertical-align: top; text-align: center"><FONT STYLE="font-size: 10pt">(Zip Code)</FONT></TD></TR>
</TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Registrant's telephone number, including area code: <B>(877)
774-4211</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"></P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Check the appropriate box below if the Form 8-K filing is intended
to simultaneously satisfy the filing obligation of the registrant under any of the following provisions (<I>see</I> General Instruction
A.2. below):</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

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<TD STYLE="width: 0"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font: 10pt Wingdings">&uml;</FONT></TD><TD><FONT STYLE="font-size: 10pt">Written communications pursuant to Rule 425 under the Securities Act (17 CFR 230.425)</FONT></TD></TR></TABLE>

<P STYLE="margin-top: 0; margin-bottom: 0">&nbsp;</P>

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<TD STYLE="width: 0"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font: 10pt Wingdings">&uml;</FONT></TD><TD><FONT STYLE="font-size: 10pt">Soliciting material pursuant to Rule 14a-12 under the Exchange Act (17 CFR 240.14a-12)</FONT></TD></TR></TABLE>

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<TD STYLE="width: 0"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font: 10pt Wingdings">&uml;</FONT></TD><TD><FONT STYLE="font-size: 10pt">Pre-commencement communications pursuant to Rule 14d-2(b) under the Exchange Act (17 CFR 240.14d-2(b))</FONT></TD></TR></TABLE>

<P STYLE="margin-top: 0; margin-bottom: 0">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 12pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font: 10pt Wingdings">&uml;</FONT></TD><TD><FONT STYLE="font-size: 10pt">Pre-commencement communications pursuant to Rule 13e-4(c) under the Exchange Act (17 CFR 240.13e-4(c))</FONT></TD></TR></TABLE>

<P STYLE="margin-top: 0; margin-bottom: 0">&nbsp;</P>

<P STYLE="margin: 0"></P>

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<P STYLE="margin: 0"></P>

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<TD STYLE="width: 0in"></TD><TD STYLE="width: 0.75in; text-align: left"><FONT STYLE="font-size: 10pt"><B>Item</B> <B> 5.02</B></FONT></TD><TD STYLE="text-align: left"><FONT STYLE="font-size: 10pt"><B>Departure
                                         of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers;
                                         Compensatory Arrangements of Certain Officers.</B></FONT></TD>
</TR></TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; text-align: center; margin-bottom: 0pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">On May 8, 2014, Elliot A. Sainer, a member of the Board of
Directors (the &ldquo;<U>Board</U>&rdquo;) of Semler Scientific, Inc. (the &ldquo;<U>Company</U>&rdquo;), notified the Board of
the Company of his resignation from the Board, including from its Audit Committee and Nominating Committee, effective as of May
8, 2014. Mr. Sainer&rsquo;s decision to resign did not involve any disagreement with the Company, the Company&rsquo;s management
or the Board. The Board accepted Mr. Sainer&rsquo;s resignation on May 8, 2014.&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">On May 8, 2014, upon the recommendation of the Nominating Committee
of the Board, the Board appointed Wayne T. Pan, MD, Ph.D., age 51, to fill the vacancy created by the departure of Mr. Sainer
and to serve as a director of the Company until the next annual meeting of stockholders or until his successor is elected and
qualified. Dr. Pan was also appointed by the Board upon the recommendation of the Nominating Committee to serve as a member of
the Audit Committee and the Nominating Committee.&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Dr. Pan has over 20 years of broad healthcare industry experience
from clinical medicine, to managed care, and health information technology. Since August 2012, Dr. Pan has been Chief Medical
Officer at Thrasys, Inc., a global healthcare technology company that provides a cloud-based platform upon which healthcare delivery
systems and provider organizations can build high quality, person-centered accountable care communities. Between October 2010
and July 2012, Dr. Pan was concurrently the Chief Medical Informatics Officer for Health Access Solutions, a health care software
development company and Chief Medical Officer of Pacific Partners Management Services, Inc., a medical management services company
serving medical groups in northern California with over 50,000 covered lives. Prior to that, between September 2009 and February
2010, he served as Chief Medical Officer for Affinity Medical Solutions, LLC, a medical management services organization serving
independent physicians association clients and managing commercial and Medicare Advantage members. Dr. Pan has also served as
Chief Medical Officer between June 2008 and August 2009 for Alameda Alliance for Health, a local initiative health plan with Medicaid,
Medicare Advantage Dual Eligible SNP and IHSS plans, and as an Advisory Chief Medical Officer at a data analytics start-up focused
on big data issues in healthcare in 2007-2008. Dr. Pan completed his undergraduate studies in Biology at Johns Hopkins University,
his MD and Ph.D. degrees concurrently at Mt. Sinai School of Medicine and he has an MBA from the Wharton School of the University
of Pennsylvania.&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">On May 14, 2014, the Company issued a press release with respect
to the foregoing, a copy of which is filed as Exhibit 99.1 hereto.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><FONT STYLE="font-size: 10pt">&nbsp;</FONT></P>

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<TD STYLE="width: 0in"></TD><TD STYLE="width: 0.75in; text-align: left"><FONT STYLE="font-size: 10pt"><B>Item</B> <B>9.01</B></FONT></TD><TD STYLE="text-align: justify"><FONT STYLE="font-size: 10pt"><B>Financial
                                         Statements and Exhibits</B></FONT></TD>
</TR></TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.25in">(d)&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Exhibits</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.25in">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
<TR STYLE="vertical-align: bottom">
    <TD STYLE="width: 12%; text-align: center"><FONT STYLE="font-size: 8pt"><B>Exhibit No.</B></FONT></TD>
    <TD STYLE="width: 1%; text-align: center"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD>
    <TD STYLE="width: 87%; text-align: center"><FONT STYLE="font-size: 8pt"><B>Description</B></FONT></TD></TR>
<TR>
    <TD STYLE="vertical-align: top; text-align: center"><FONT STYLE="font-size: 10pt">99.1</FONT></TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: top; padding-left: 20.9pt"><FONT STYLE="font-size: 10pt">Press Release of Semler Scientific, Inc., dated May 14, 2014</FONT></TD></TR>
</TABLE>

<P STYLE="margin-top: 0; margin-bottom: 0">&nbsp;</P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>SIGNATURES</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">Pursuant to the requirements of the Securities
Exchange Act of 1934, as amended, the registrant has duly caused this report to be signed on its behalf by the undersigned hereunto
duly authorized.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" ALIGN="RIGHT" STYLE="font: 10pt Times New Roman, Times, Serif; width: 45%; border-collapse: collapse">
<TR STYLE="vertical-align: top">
    <TD COLSPAN="3"><FONT STYLE="font: 10pt Times New Roman, Times, Serif; text-transform: uppercase"><B>SEMLER SCIENTIFIC, INC.</B></FONT></TD></TR>
<TR>
    <TD>&nbsp;</TD>
    <TD COLSPAN="2">&nbsp;</TD></TR>
<TR>
    <TD STYLE="vertical-align: top; padding-left: 12pt; text-indent: -12pt"><FONT STYLE="font-size: 10pt">By:</FONT></TD>
    <TD COLSPAN="2" STYLE="vertical-align: bottom; border-bottom: black 1pt solid"><FONT STYLE="font-size: 10pt">/s/ Dan Conger</FONT></TD></TR>
<TR>
    <TD STYLE="vertical-align: top; width: 10%; padding-left: 12pt; text-indent: -12pt">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; width: 20%"><FONT STYLE="font-size: 10pt">Name:</FONT></TD>
    <TD STYLE="vertical-align: top; width: 70%"><FONT STYLE="font-size: 10pt">Dan Conger</FONT></TD></TR>
<TR>
    <TD STYLE="vertical-align: top">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom"><FONT STYLE="font-size: 10pt">Title:</FONT></TD>
    <TD STYLE="vertical-align: bottom"><FONT STYLE="font-size: 10pt">VP Finance</FONT></TD></TR>
</TABLE><BR STYLE="clear: both"><P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Date: May 14, 2014</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

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{"company-data": {"conformed-name": "Semler Scientific, Inc.", "cik": "0001554859", "assigned-sic": "3845", "irs-number": "261367393", "state-of-incorporation": "DE", "fiscal-year-end": "1231"}, "filing-values": {"form-type": "8-K", "act": "34", "file-number": "001-36305", "film-number": "14840208"}, "business-address": {"street1": "2330 N.W. EVERETT STREET", "city": "PORTLAND", "state": "OR", "zip": "97210", "phone": "408-627-4557"}, "mail-address": {"street1": "2330 N.W. EVERETT STREET", "city": "PORTLAND", "state": "OR", "zip": "97210"}}
UNITED STATES
SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 8-K
CURRENT REPORT
Pursuant to Section 13 or 15(d)
of the
Securities Exchange Act of 1934
Date of Report (Date of earliest
event reported): May 8, 2014
SEMLER SCIENTIFIC, INC.
(Exact name of registrant as specified
in its charter)
Delaware
001-36305
26-1367393
(State or other jurisdiction of
incorporation)
(Commission File Number)
(IRS Employer Identification No.)
2330 NW Everett St.
Portland, Oregon
97210
(Address of principal executive offices)
(Zip Code)
Registrant's telephone number, including area code:
(877)
774-4211
Check the appropriate box below if the Form 8-K filing is intended
to simultaneously satisfy the filing obligation of the registrant under any of the following provisions (
see
General Instruction
A.2. below):
¨
Written communications pursuant to Rule 425 under the Securities Act (17 CFR 230.425)
¨
Soliciting material pursuant to Rule 14a-12 under the Exchange Act (17 CFR 240.14a-12)
¨
Pre-commencement communications pursuant to Rule 14d-2(b) under the Exchange Act (17 CFR 240.14d-2(b))
¨
Pre-commencement communications pursuant to Rule 13e-4(c) under the Exchange Act (17 CFR 240.13e-4(c))
Item
5.02
Departure
                                         of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers;
                                         Compensatory Arrangements of Certain Officers.
On May 8, 2014, Elliot A. Sainer, a member of the Board of
Directors (the "
Board
") of Semler Scientific, Inc. (the "
Company
"), notified the Board of
the Company of his resignation from the Board, including from its Audit Committee and Nominating Committee, effective as of May
8, 2014. Mr. Sainer's decision to resign did not involve any disagreement with the Company, the Company's management
or the Board. The Board accepted Mr. Sainer's resignation on May 8, 2014.
On May 8, 2014, upon the recommendation of the Nominating Committee
of the Board, the Board appointed Wayne T. Pan, MD, Ph.D., age 51, to fill the vacancy created by the departure of Mr. Sainer
and to serve as a director of the Company until the next annual meeting of stockholders or until his successor is elected and
qualified. Dr. Pan was also appointed by the Board upon the recommendation of the Nominating Committee to serve as a member of
the Audit Committee and the Nominating Committee.
Dr. Pan has over 20 years of broad healthcare industry experience
from clinical medicine, to managed care, and health information technology. Since August 2012, Dr. Pan has been Chief Medical
Officer at Thrasys, Inc., a global healthcare technology company that provides a cloud-based platform upon which healthcare delivery
systems and provider organizations can build high quality, person-centered accountable care communities. Between October 2010
and July 2012, Dr. Pan was concurrently the Chief Medical Informatics Officer for Health Access Solutions, a health care software
development company and Chief Medical Officer of Pacific Partners Management Services, Inc., a medical management services company
serving medical groups in northern California with over 50,000 covered lives. Prior to that, between September 2009 and February
2010, he served as Chief Medical Officer for Affinity Medical Solutions, LLC, a medical management services organization serving
independent physicians association clients and managing commercial and Medicare Advantage members. Dr. Pan has also served as
Chief Medical Officer between June 2008 and August 2009 for Alameda Alliance for Health, a local initiative health plan with Medicaid,
Medicare Advantage Dual Eligible SNP and IHSS plans, and as an Advisory Chief Medical Officer at a data analytics start-up focused
on big data issues in healthcare in 2007-2008. Dr. Pan completed his undergraduate studies in Biology at Johns Hopkins University,
his MD and Ph.D. degrees concurrently at Mt. Sinai School of Medicine and he has an MBA from the Wharton School of the University
of Pennsylvania.
On May 14, 2014, the Company issued a press release with respect
to the foregoing, a copy of which is filed as Exhibit 99.1 hereto.
Item
9.01
Financial
                                         Statements and Exhibits
(d)      Exhibits
Exhibit No.
Description
99.1
Press Release of Semler Scientific, Inc., dated May 14, 2014
SIGNATURES
Pursuant to the requirements of the Securities
Exchange Act of 1934, as amended, the registrant has duly caused this report to be signed on its behalf by the undersigned hereunto
duly authorized.
SEMLER SCIENTIFIC, INC.
By:
/s/ Dan Conger
Name:
Dan Conger
Title:
VP Finance
Date: May 14, 2014