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			87b95e0bc3a7467
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			<a name="eolPage1"></a><a name="FIS_TOP_OF_DOCUMENT"></a><a name="D480594D8K_HTM"></a><a name="FIS_FORM"></a><a name="_GoBack"></a><font style="display: inline;font-family:Times New Roman;font-size:10pt;">&nbsp;</font>
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			<font style="display: inline;font-family:Times New Roman;font-size:10pt;">&nbsp;</font>
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			<font style="display: inline;font-family:Times New Roman;font-weight:bold;font-size:18pt;">UNITED STATES</font>
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			<font style="display: inline;font-family:Times New Roman;font-weight:bold;font-size:18pt;">SECURITIES AND EXCHANGE COMMISSION</font>
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			<font style="display: inline;font-family:Times New Roman;font-weight:bold;font-size:12pt;">Washington, DC 20549</font>
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		<p style="margin:9pt 0pt 0pt;line-height:100%;text-align:center;font-family:Calibri;font-size: 18pt">
			<font style="display: inline;font-family:Times New Roman;font-weight:bold;font-size:18pt;">FORM 8-K</font>
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			<font style="display: inline;font-family:Times New Roman;font-size:9pt;">&nbsp;</font>
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			<font style="display: inline;font-family:Times New Roman;font-size:10pt;">&nbsp;</font>
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			<font style="display: inline;font-family:Times New Roman;font-weight:bold;font-size:13.5pt;">CURRENT REPORT</font>
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		<p style="margin:9pt 0pt 0pt;line-height:100%;text-align:center;font-family:Calibri;font-size: 12pt">
			<font style="display: inline;font-family:Times New Roman;font-weight:bold;font-size:12pt;">Pursuant to Section&nbsp;13 or 15(d) of</font>
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			<font style="display: inline;font-family:Times New Roman;font-weight:bold;font-size:12pt;">The Securities Exchange Act of 1934</font>
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			<font style="display: inline;font-family:Times New Roman;font-weight:bold;font-size:12pt;">Date of Report (Date of earliest event reported)</font>
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			<font style="display: inline;font-family:Times New Roman;font-weight:bold;font-size:12pt;">September 2</font><font style="display: inline;font-family:Times New Roman;font-weight:bold;font-size:12pt;">3</font><font style="display: inline;font-family:Times New Roman;font-weight:bold;font-size:12pt;">, 2013</font>
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			<font style="display: inline;font-family:Times New Roman;font-size:9pt;">&nbsp;</font>
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			<font style="display: inline;font-family:Times New Roman;font-size:10pt;">&nbsp;</font><a name="FIS_UNIDENTIFIED_TABLE"></a>
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		<p style="margin:9pt 0pt 0pt;line-height:100%;text-align:center;font-family:Calibri;font-size: 24pt">
			<font style="display: inline;font-family:Times New Roman;font-weight:bold;font-size:24pt;">Pacific Biosciences of California, Inc.</font>
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		<p style="margin:0pt;line-height:100%;text-align:center;font-family:Calibri;font-size: 10pt">
			<font style="display: inline;font-family:Times New Roman;font-weight:bold;font-size:10pt;">(Exact name of registrant as specified in its charter)</font>
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			<font style="display: inline;font-family:Times New Roman;font-size:9pt;">&nbsp;</font>
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			<font style="display: inline;font-family:Times New Roman;font-size:10pt;">&nbsp;</font>
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						<font style="display: inline;font-family:Times New Roman;font-size:12pt;">&nbsp;</font></p>
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						&nbsp;</p>
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					<p style="margin:0pt 0.8pt 0pt 0pt;line-height:100%;text-align:center;font-family:Calibri;font-size: 10pt">
						<font style="display: inline;font-family:Times New Roman;font-weight:bold;font-size:10pt;">Delaware</font></p>
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					<p style="margin:0pt 0.8pt 0pt 0pt;line-height:100%;font-family:Calibri;font-size: 7pt">
						<font style="display: inline;font-family:Times New Roman;font-size:7.5pt;">&nbsp;</font></p>
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					<p style="margin:0pt 0.8pt 0pt 0pt;line-height:100%;text-align:center;font-family:Calibri;font-size: 10pt">
						<font style="display: inline;font-family:Times New Roman;font-weight:bold;font-size:10pt;">001-34899</font></p>
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						<font style="display: inline;font-family:Times New Roman;font-size:7.5pt;">&nbsp;</font></p>
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					<p style="margin:0pt 0.8pt 0pt 0pt;line-height:100%;text-align:center;font-family:Calibri;font-size: 10pt">
						<font style="display: inline;font-family:Times New Roman;font-weight:bold;font-size:10pt;">16-1590339</font></p>
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					<p style="margin:0pt 0.8pt 0pt 0pt;line-height:100%;text-align:center;font-family:Calibri;font-size: 7pt">
						<font style="display: inline;font-family:Times New Roman;font-weight:bold;font-size:7.5pt;">(State or other jurisdiction</font></p>
					<p style="margin:0pt 0.8pt 0pt 0pt;line-height:100%;text-align:center;font-family:Calibri;font-size: 7pt">
						<font style="display: inline;font-family:Times New Roman;font-weight:bold;font-size:7.5pt;">of incorporation)</font></p>
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					<p style="margin:0pt 0.8pt 0pt 0pt;line-height:100%;font-family:Calibri;font-size: 7pt">
						<font style="display: inline;font-family:Times New Roman;font-size:7.5pt;">&nbsp;</font></p>
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					<p style="margin:0pt 0.8pt 0pt 0pt;line-height:100%;text-align:center;font-family:Calibri;font-size: 7pt">
						<font style="display: inline;font-family:Times New Roman;font-weight:bold;font-size:7.5pt;">(Commission</font></p>
					<p style="margin:0pt 0.8pt 0pt 0pt;line-height:100%;text-align:center;font-family:Calibri;font-size: 7pt">
						<font style="display: inline;font-family:Times New Roman;font-weight:bold;font-size:7.5pt;">File Number)</font></p>
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					<p style="margin:0pt 0.8pt 0pt 0pt;line-height:100%;font-family:Calibri;font-size: 7pt">
						<font style="display: inline;font-family:Times New Roman;font-size:7.5pt;">&nbsp;</font></p>
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					<p style="margin:0pt 0.8pt 0pt 0pt;line-height:100%;text-align:center;font-family:Calibri;font-size: 7pt">
						<font style="display: inline;font-family:Times New Roman;font-weight:bold;font-size:7.5pt;">(IRS Employer</font></p>
					<p style="margin:0pt 0.8pt 0pt 0pt;line-height:100%;text-align:center;font-family:Calibri;font-size: 7pt">
						<font style="display: inline;font-family:Times New Roman;font-weight:bold;font-size:7.5pt;">Identification No.)</font></p>
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		<p style="margin:9pt 0pt 0pt;line-height:100%;text-align:center;font-family:Calibri;font-size: 10pt">
			<font style="display: inline;font-family:Times New Roman;font-weight:bold;font-size:10pt;">1380 Willow Road</font>
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		<p style="margin:0pt;line-height:100%;text-align:center;font-family:Calibri;font-size: 10pt">
			<font style="display: inline;font-family:Times New Roman;font-weight:bold;font-size:10pt;">Menlo Park, California 94025</font>
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		<p style="margin:0pt;line-height:100%;text-align:center;font-family:Calibri;font-size: 7pt">
			<font style="display: inline;font-family:Times New Roman;font-weight:bold;font-size:7.5pt;">(Address of principal executive offices, including zip code)</font>
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		<p style="margin:9pt 0pt 0pt;line-height:100%;text-align:center;font-family:Calibri;font-size: 10pt">
			<font style="display: inline;font-family:Times New Roman;font-weight:bold;font-size:10pt;">(650) 521-8000</font>
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		<p style="margin:0pt;line-height:100%;text-align:center;font-family:Calibri;font-size: 7pt">
			<font style="display: inline;font-family:Times New Roman;font-weight:bold;font-size:7.5pt;">(Registrant&#x2019;s telephone number, including area code)</font>
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		<p style="margin:0pt;line-height:100%;font-family:Calibri;font-size: 9pt">
			<font style="display: inline;font-family:Times New Roman;font-size:9pt;">&nbsp;</font>
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		<p style="margin:9pt 0pt 0pt;line-height:100%;text-align:center;font-family:Calibri;font-size: 7pt">
			<font style="display: inline;font-family:Times New Roman;font-weight:bold;font-size:7.5pt;">(Former name or former address, if changed since last report)</font>
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		<p style="margin:0pt;line-height:100%;font-family:Calibri;font-size: 9pt">
			<font style="display: inline;font-family:Times New Roman;font-size:9pt;">&nbsp;</font>
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		<p style="margin:0pt 227.4pt;border-bottom:1pt solid #000000 ;line-height:100%;text-align:center;font-family:Calibri;font-size: 10pt">
			<font style="display: inline;font-family:Times New Roman;font-size:10pt;">&nbsp;</font>
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		<p style="margin:9pt 0pt 0pt;line-height:100%;font-family:Calibri;font-size: 10pt">
			<font style="display: inline;font-family:Times New Roman;font-size:10pt;">Check the appropriate box below if the Form 8-K filing is intended to simultaneously satisfy the filing obligation of the registrant under any of the following provisions (see General Instruction A.2):</font>
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		<p style="margin:0pt;line-height:100%;font-family:Calibri;font-size: 5pt">
			<font style="display: inline;font-family:Times New Roman;font-size:5pt;">&nbsp;</font>
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						<font style="display: inline;font-family:Wingdings;font-size:10pt;">&#xA8;</font></p>
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					<p style="margin:0pt 0.8pt 0pt 0pt;line-height:100%;font-family:Calibri;font-size: 10pt">
						<font style="display: inline;font-family:Times New Roman;font-size:10pt;">Written communications pursuant to Rule 425 under the Securities Act (17 CFR 230.425)</font></p>
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			<font style="display: inline;font-family:Times New Roman;font-size:5pt;">&nbsp;</font>
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						<font style="display: inline;font-family:Wingdings;font-size:10pt;">&#xA8;</font></p>
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					<p style="margin:0pt 0.8pt 0pt 0pt;line-height:100%;font-family:Calibri;font-size: 10pt">
						<font style="display: inline;font-family:Times New Roman;font-size:10pt;">Soliciting material pursuant to Rule 14a-12 under the Exchange Act (17 CFR 240.14a-12)</font></p>
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		<p style="margin:0pt;line-height:100%;font-family:Calibri;font-size: 5pt">
			<font style="display: inline;font-family:Times New Roman;font-size:5pt;">&nbsp;</font>
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					<p style="margin:0pt 0.8pt 0pt 0pt;line-height:100%;font-family:Calibri;font-size: 10pt">
						<font style="display: inline;font-family:Wingdings;font-size:10pt;">&#xA8;</font></p>
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					<p style="margin:0pt 0.8pt 0pt 0pt;line-height:100%;font-family:Calibri;font-size: 10pt">
						<font style="display: inline;font-family:Times New Roman;font-size:10pt;">Pre-commencement communications pursuant to Rule 14d-2(b) under the Exchange Act (17 CFR 240.14d-2(b))</font></p>
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		<p style="margin:0pt;line-height:100%;font-family:Calibri;font-size: 5pt">
			<font style="display: inline;font-family:Times New Roman;font-size:5pt;">&nbsp;</font>
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						<font style="display: inline;font-family:Wingdings;font-size:10pt;">&#xA8;</font></p>
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						<font style="display: inline;font-family:Times New Roman;font-size:10pt;">Pre-commencement communications pursuant to Rule 13e-4(c) under the Exchange Act (17 CFR 240.13e-4(c))</font></p>
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			<font style="display: inline;font-family:Times New Roman;font-size:10pt;">&nbsp;</font><a name="eolPage2"></a>
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		<p><font size="1"> </font></p><hr size="3" style="color:#999999" width="100%" align="center"></hr><p style="page-break-after:always">&nbsp;</p>
		<p style="margin:0pt;line-height:0.05pt;font-family:Calibri;;font-size: 12pt"><font style="display: inline;font-family:Times New Roman;font-size:12pt;">&nbsp;</font>
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			<a name="FIS_SECTION_1_BUSINESS_AND_OPERATIONS"></a><a name="FIS_ENTRY_MATERIAL_AGREEMENT"></a><font style="display: inline;font-family:Times New Roman;font-size:12pt;">&nbsp;</font>
		</p>
		<p style="margin:0pt;line-height:11.25pt;font-family:Calibri;font-size: 10pt">
			<font style="display: inline;font-family:Times New Roman;font-size:10pt;">&nbsp;</font>
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					<p style="margin:0pt 0.8pt 0pt 0pt;line-height:100%;font-family:Calibri;font-size: 10pt">
						<font style="display: inline;font-family:Times New Roman;font-weight:bold;font-size:10pt;">ITEM&nbsp;1.01.</font></p>
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					<p style="margin:0pt 0.8pt 0pt 0pt;line-height:100%;font-family:Calibri;font-size: 10pt">
						<font style="display: inline;font-family:Times New Roman;font-weight:bold;font-size:10pt;">ENTRY INTO A MATERIAL DEFINITIVE AGREEMENT.</font></p>
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		<p style="margin:0pt;line-height:100%;font-family:Calibri;font-size: 10pt">
			<font style="display: inline;font-family:Times New Roman;font-size:10pt;">&nbsp;</font>
		</p>
		<p style="margin:0pt;line-height:100%;font-family:Calibri;font-size: 10pt">
			<font style="display: inline;font-family:Times New Roman;font-size:10pt;">On September 2</font><font style="display: inline;font-family:Times New Roman;font-size:10pt;">3</font><font style="display: inline;font-family:Times New Roman;font-size:10pt;">, 2013 Pacific Biosciences of California, Inc. (the &#x201C;Company&#x201D;) entered into a Development, Commercialization and License Agreement (the &#x201C;Agreement&#x201D;) with F. Hoffman-La Roche Ltd (&#x201C;Roche&#x201D;), pursuant to which the Company: (i) </font><font style="display: inline;font-family:Times New Roman;font-size:10pt;">will </font><font style="display: inline;font-family:Times New Roman;font-size:10pt;">develop diagnostic products for clinical use including sequencing systems and consumables based on the Company&#x2019;s proprietary Single Molecule, Real-Time (SMRT&#xAE;) technology; (ii) </font><font style="display: inline;font-family:Times New Roman;font-size:10pt;">has </font><font style="display: inline;font-family:Times New Roman;font-size:10pt;">grant</font><font style="display: inline;font-family:Times New Roman;font-size:10pt;">ed</font><font style="display: inline;font-family:Times New Roman;font-size:10pt;"> to Roche an exclusive right to commercialize, and an exclusive license to sell, the developed diagnostic products for clinical use, the exclusivity of which is contingent on achieving sales minimums to be established in the future and contingent on Roche not selling </font><font style="display: inline;font-family:Times New Roman;font-size:10pt;">for clinical use </font><font style="display: inline;font-family:Times New Roman;font-size:10pt;">a</font><font style="display: inline;font-family:Times New Roman;font-size:10pt;">ny new</font><font style="display: inline;font-family:Times New Roman;font-size:10pt;">&nbsp;</font><font style="display: inline;font-family:Times New Roman;font-size:10pt;">sequencing instrument that competes with any diagnostic instrument system developed under the Agreement</font><font style="display: inline;font-family:Times New Roman;font-size:10pt;">; and (iii) </font><font style="display: inline;font-family:Times New Roman;font-size:10pt;">will </font><font style="display: inline;font-family:Times New Roman;font-size:10pt;">manufacture and supply certain products </font><font style="display: inline;font-family:Times New Roman;font-size:10pt;">intended</font><font style="display: inline;font-family:Times New Roman;font-size:10pt;"> for clinical use as the exclusive supplier to Roche.</font><font style="display: inline;font-family:Times New Roman;font-size:10pt;">&nbsp;</font><font style="display: inline;font-family:Times New Roman;font-size:10pt;">The Company will receive up to $75 million from Roche comprised of a non-refundable up-front payment of $35 million and up to an additional $40 million based upon the achievement of development milestones</font><font style="display: inline;font-family:Times New Roman;font-size:10pt;">.</font><font style="display: inline;font-family:Times New Roman;font-size:10pt;">&nbsp;</font><font style="display: inline;font-family:Times New Roman;font-size:10pt;">The Agreement has an initial term of thirteen years and provisions allowing Roche 5-year renewals, contingent on Roche meeting sales minimums.</font>
		</p>
		<p style="margin:0pt;line-height:100%;font-family:Calibri;font-size: 10pt">
			<font style="display: inline;font-family:Times New Roman;font-size:10pt;">&nbsp;</font>
		</p>
		<p style="margin:0pt;line-height:100%;font-family:Calibri;font-size: 10pt">
			<font style="display: inline;font-family:Times New Roman;font-size:10pt;">Roche&#x2019;s </font><font style="display: inline;font-family:Times New Roman;font-size:10pt;">exclusive right to commercialize and exclusive license to sell</font><font style="display: inline;font-family:Times New Roman;font-size:10pt;">,</font><font style="display: inline;font-family:Times New Roman;font-size:10pt;"> servic</font><font style="display: inline;font-family:Times New Roman;font-size:10pt;">e, and provide services using</font><font style="display: inline;font-family:Times New Roman;font-size:10pt;"> the developed diagnostic products is limited to</font><font style="display: inline;font-family:Times New Roman;font-size:10pt;">&nbsp;</font><font style="display: inline;font-family:Times New Roman;font-size:10pt;">nucleic acid sequencing for medical management of a human being and quality control or testing of human blood or tissue for transfusion or blood banking, human bone marrow transplantation or banking, or human tis</font><font style="display: inline;font-family:Times New Roman;font-size:10pt;">sue typing for transplantation. </font><font style="display: inline;font-family:Times New Roman;font-size:10pt;">All other applications and uses are specifically excluded.</font><font style="display: inline;font-family:Times New Roman;font-size:10pt;">&nbsp;</font><font style="display: inline;font-family:Times New Roman;font-size:10pt;">The Company retains the rights to all other applications and uses and will continue to market its current and future products.</font>
		</p>
		<p style="margin:0pt;line-height:100%;font-family:Calibri;font-size: 10pt">
			<font style="display: inline;font-family:Times New Roman;font-size:10pt;">&nbsp;</font><a name="FIS_SECTION_3_SECURITIES_AND_TRADING_MAR"></a><a name="FIS_SALE_OF_EQUITY"></a>
		</p>
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					<p style="margin:0pt 0.8pt 0pt 0pt;line-height:100%;font-family:Calibri;font-size: 10pt">
						<font style="display: inline;font-family:Times New Roman;font-weight:bold;font-size:10pt;">ITEM&nbsp;7.01.</font></p>
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					<p style="margin:0pt 0.8pt 0pt 0pt;line-height:100%;font-family:Calibri;font-size: 10pt">
						<font style="display: inline;font-family:Times New Roman;font-weight:bold;font-size:10pt;">REGULATION FD DISCLOSURE.</font></p>
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		<p style="margin:4.5pt 0pt 0pt;line-height:100%;font-family:Calibri;font-size: 10pt">
			<font style="display: inline;font-family:Times New Roman;font-size:10pt;">&nbsp;</font>
		</p>
		<p style="margin:0pt;line-height:100%;font-family:Calibri;font-size: 10pt">
			<font style="display: inline;font-family:Times New Roman;font-size:10pt;">On September 25, 20</font><font style="display: inline;font-family:Times New Roman;font-size:10pt;">1</font><font style="display: inline;font-family:Times New Roman;font-size:10pt;">3 Pacific Biosciences of California, Inc. (the &#x201C;Company&#x201D;) issued a press release announcing a Development, Commercialization and License Agreement with Roche Diagnostics, a division of F. Hoffman-La Roche Ltd.</font><font style="display: inline;font-family:Times New Roman;font-size:10pt;">&nbsp;</font><font style="display: inline;font-family:Times New Roman;font-size:10pt;">A copy of the Company&#x2019;s press release is furnished as Exhibit 99.1 hereto.</font>
		</p>
		<p style="margin:0pt;line-height:100%;font-family:Calibri;font-size: 10pt">
			<font style="display: inline;font-family:Times New Roman;font-size:10pt;">&nbsp;</font>
		</p>
		<p style="margin:0pt;line-height:100%;font-family:Calibri;font-size: 10pt">
			<font style="display: inline;font-family:Times New Roman;font-size:10pt;">The information in Item 7.01 of this Current Report on Form 8-K, including the information in Exhibit 99.1 hereto, is furnished pursuant to Item 7.01 of Form 8-K and shall not be deemed "filed" for any purpose, including for the purposes of Section 18 of the Exchange Act, or otherwise subject to the liabilities of that Section. The information in Item 7.01 of this Current Report on Form 8-K, including the information in Exhibit 99.1 hereto, shall not be deemed incorporated by reference into any filing under the Securities Act, or the Exchange Act regardless of any general incorporation language in such filing.</font>
		</p>
		<p style="margin:0pt;line-height:100%;font-family:Calibri;font-size: 13pt">
			<font style="display: inline;font-family:Times New Roman;font-size:13.5pt;">&nbsp;</font><a name="FIS_SECTION_9_FINANCIAL_STATEMENTS_AND_E"></a><a name="FIS_FINANCIAL_STATEMENTS_AND_EXHIBITS"></a>
		</p>
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					<p style="margin:0pt 0.8pt 0pt 0pt;line-height:100%;font-family:Calibri;font-size: 10pt">
						<font style="display: inline;font-family:Times New Roman;font-weight:bold;font-size:10pt;">ITEM&nbsp;9.01.</font></p>
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					<p style="margin:0pt 0.8pt 0pt 0pt;line-height:100%;font-family:Calibri;font-size: 10pt">
						<font style="display: inline;font-family:Times New Roman;font-weight:bold;font-size:10pt;">FINANCIAL STATEMENTS AND EXHIBITS.</font></p>
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		<p style="margin:0pt;line-height:100%;font-family:Calibri;font-size: 5pt">
			<font style="display: inline;font-family:Times New Roman;font-size:5pt;">&nbsp;</font>
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					<p style="margin:0pt;line-height:normal;font-family:Calibri;height:1.00pt;overflow:hidden;font-size: 1pt">
						<font style="display: inline;font-size:1pt;">&nbsp;</font></p>
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					<p style="margin:0pt 0pt 10pt;font-family:Calibri;line-height:115%;height:1.00pt;overflow:hidden;font-size: 11pt">
						&nbsp;</p>
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					<p style="margin:0pt 0pt 10pt;font-family:Calibri;line-height:115%;height:1.00pt;overflow:hidden;font-size: 11pt">
						&nbsp;</p>
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					<p style="margin:0pt 0.8pt 0pt 0pt;line-height:100%;font-family:Calibri;font-size: 7pt">
						<font style="display: inline;font-family:Times New Roman;font-size:7.5pt;">&nbsp;</font></p>
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						<font style="display: inline;font-family:Times New Roman;font-size:10pt;">(d)</font></p>
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						<font style="display: inline;font-family:Times New Roman;font-size:10pt;">Exhibits.</font></p>
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						<font style="display: inline;font-family:Times New Roman;font-size:9pt;">&nbsp;</font><a name="FIS_UNIDENTIFIED_TABLE_2"></a><a name="eolPage4"></a><a name="FIS_SIGNATURES"></a></p>
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					<p style="margin:0pt 0pt 10pt;font-family:Calibri;line-height:115%;height:1.00pt;overflow:hidden;font-size: 11pt">
						&nbsp;</p>
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						&nbsp;</p>
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						<font style="display: inline;font-family:Times New Roman;font-size:12pt;">&nbsp;</font></p>
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						&nbsp;</p>
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						&nbsp;</p>
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					<p style="margin:0pt;line-height:6pt;font-family:Calibri;font-size: 12pt">
						<font style="display: inline;font-family:Times New Roman;font-size:12pt;">&nbsp;</font></p>
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				<td colspan="3" valign="middle" style="width:546.85pt;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;border-right:1pt none #D9D9D9 ;padding:0pt;">
					<p style="margin:0pt;line-height:6pt;font-family:Calibri;font-size: 11pt">
						&nbsp;</p>
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				<td colspan="2" valign="top" style="width:29.15pt;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;border-right:1pt none #D9D9D9 ;padding:0pt;">
					<p style="margin:0pt 0.8pt 0pt 0pt;line-height:100%;font-family:Calibri;font-size: 10pt">
						<font style="display: inline;font-family:Times New Roman;font-size:10pt;">99.1</font></p>
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				<td valign="bottom" style="width:18.00pt;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;border-right:1pt none #D9D9D9 ;padding:0pt;">
					<p style="margin:0pt 0.8pt 0pt 0pt;line-height:100%;font-family:Calibri;font-size: 7pt">
						<font style="display: inline;font-family:Times New Roman;font-size:7.5pt;">&nbsp;&nbsp;</font></p>
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				<td colspan="2" valign="top" style="width:528.85pt;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;border-right:1pt none #D9D9D9 ;padding:0pt;">
					<p style="margin:0pt 0.7pt 0pt 0pt;line-height:100%;font-family:Calibri;font-size: 10pt">
						<font style="display: inline;font-family:Times New Roman;font-size:10pt;">Press Release dated September 25, 2013 titled &#x201C;Pacific Biosciences Announces Agreement with Roche Diagnostics To Develop and Supply DNA Sequencing-Based Products for Clinical Diagnostics.&#x201D;</font></p>
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		</table></div>
		<p style="margin:0pt;line-height:normal;font-family:Calibri;font-size: 11pt">
			<font style="display: inline;">&nbsp;</font>
		</p>
		<p style="margin:11.25pt 0pt 0pt 0.75pt;border-top:1pt solid #808080 ;border-left:1pt solid #808080 ;border-bottom:1pt solid #808080 ;border-right:1pt solid #808080 ;line-height:2.25pt;text-align:center;font-family:Calibri;font-size: 12pt">
			<font style="display: inline;font-family:Times New Roman;font-size:12pt;">&nbsp;</font>
		</p>
		<p style="margin:11.25pt 0pt 0pt;line-height:100%;text-align:center;font-family:Calibri;font-size: 10pt">
			<font style="display: inline;font-family:Times New Roman;font-weight:bold;font-size:10pt;">SIGNATURE</font>
		</p>
		<p style="margin:9pt 0pt 0pt;line-height:100%;font-family:Calibri;font-size: 10pt">
			<font style="display: inline;font-family:Times New Roman;font-size:10pt;">Pursuant to the requirements of the Securities Exchange Act of 1934, the registrant has duly caused this report to be signed on its behalf by the undersigned hereunto duly authorized.</font>
		</p>
		<p style="margin:0pt;line-height:100%;font-family:Calibri;font-size: 9pt">
			<font style="display: inline;font-family:Times New Roman;font-size:9pt;">&nbsp;</font>
		</p>
		<div style="width:100%"><table cellpadding="0" cellspacing="0" style="border-collapse:collapse;margin-left:345.4pt;">
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					<p style="margin:0pt;line-height:0.05pt;font-family:Calibri;font-size: 12pt">
						<font style="display: inline;font-family:Times New Roman;font-size:12pt;">&nbsp;</font></p>
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					<p style="margin:0pt;line-height:0.05pt;font-family:Calibri;font-size: 11pt">
						&nbsp;</p>
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					<p style="margin:0pt;line-height:0.05pt;font-family:Calibri;font-size: 11pt">
						&nbsp;</p>
				</td>
			</tr>
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					<p style="margin:0pt 2.8pt 0pt 0pt;line-height:100%;font-family:Calibri;font-size: 10pt">
						<font style="display: inline;font-family:Times New Roman;font-weight:bold;font-size:10pt;">Pacific Biosciences of California, Inc.</font></p>
				</td>
			</tr>
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					<p style="margin:0pt;line-height:12pt;font-family:Calibri;font-size: 12pt">
						<font style="display: inline;font-family:Times New Roman;font-size:12pt;">&nbsp;</font></p>
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					<p style="margin:0pt;line-height:12pt;font-family:Calibri;font-size: 11pt">
						&nbsp;</p>
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					<p style="margin:0pt 0.8pt 0pt 0pt;line-height:100%;font-family:Calibri;font-size: 10pt">
						<font style="display: inline;font-family:Times New Roman;font-size:10pt;">By:</font></p>
				</td>
				<td valign="bottom" style="width:05.50pt;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;border-right:1pt none #D9D9D9 ;padding:0pt;">
					<p style="margin:0pt 0.8pt 0pt 0pt;line-height:100%;font-family:Calibri;font-size: 7pt">
						<font style="display: inline;font-family:Times New Roman;font-size:7.5pt;">&nbsp;</font></p>
				</td>
				<td valign="top" style="width:207.00pt;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;border-right:1pt none #D9D9D9 ;padding:0pt;">
					<p style="margin:0pt 0.8pt 0pt 0pt;border-bottom:1pt solid #000000 ;line-height:100%;text-align:center;font-family:Calibri;font-size: 10pt">
						<font style="display: inline;font-family:Times New Roman;font-size:10pt;">/s/&nbsp;&nbsp;&nbsp;&nbsp;Brian B. Dow&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</font></p>
				</td>
			</tr>
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				<td valign="top" style="width:17.90pt;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;border-right:1pt none #D9D9D9 ;padding:0pt;">
					<p style="margin:0pt;line-height:0.05pt;font-family:Calibri;font-size: 12pt">
						<font style="display: inline;font-family:Times New Roman;font-size:12pt;">&nbsp;</font></p>
				</td>
				<td valign="bottom" style="width:05.50pt;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;border-right:1pt none #D9D9D9 ;padding:0pt;">
					<p style="margin:0pt 0.8pt 0pt 0pt;line-height:100%;font-family:Calibri;font-size: 7pt">
						<font style="display: inline;font-family:Times New Roman;font-size:7.5pt;">&nbsp;</font></p>
				</td>
				<td valign="top" style="width:207.00pt;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;border-right:1pt none #D9D9D9 ;padding:0pt;">
					<p style="margin:0pt 0.8pt 0pt 0pt;line-height:100%;text-align:center;font-family:Calibri;font-size: 7pt">
						<font style="display: inline;font-family:Times New Roman;font-weight:bold;font-size:7.5pt;">Brian B. Dow</font></p>
				</td>
			</tr>
			<tr>
				<td valign="top" style="width:17.90pt;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;border-right:1pt none #D9D9D9 ;padding:0pt;">
					<p style="margin:0pt;line-height:0.05pt;font-family:Calibri;font-size: 12pt">
						<font style="display: inline;font-family:Times New Roman;font-size:12pt;">&nbsp;</font></p>
				</td>
				<td valign="bottom" style="width:05.50pt;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;border-right:1pt none #D9D9D9 ;padding:0pt;">
					<p style="margin:0pt 0.8pt 0pt 0pt;line-height:100%;font-family:Calibri;font-size: 7pt">
						<font style="display: inline;font-family:Times New Roman;font-size:7.5pt;">&nbsp;</font></p>
				</td>
				<td valign="top" style="width:207.00pt;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;border-right:1pt none #D9D9D9 ;padding:0pt;">
					<p style="margin:0pt 0.8pt 0pt 0pt;line-height:100%;text-align:center;font-family:Calibri;font-size: 7pt">
						<font style="display: inline;font-family:Times New Roman;font-weight:bold;font-size:7.5pt;">Vice President and Principal Accounting Officer</font></p>
				</td>
			</tr>
		</table></div>
		<p style="margin:9pt 0pt 0pt;line-height:100%;font-family:Calibri;font-size: 10pt">
			<font style="display: inline;font-family:Times New Roman;font-size:10pt;">Date: September 25, 2013</font><a name="eolPage5"></a>
		</p>
		<p style="margin:0pt;line-height:0.05pt;font-family:Calibri;font-size: 12pt">

		</p>
		<p><font size="1"> </font></p><hr size="3" style="color:#999999" width="100%" align="center"></hr><p style="page-break-after:always">&nbsp;</p>
		<p style="margin:0pt;line-height:0.05pt;font-family:Calibri;;font-size: 12pt"><font style="display: inline;font-family:Times New Roman;font-size:12pt;">&nbsp;</font>
		</p>
		<p style="margin:11.25pt 0pt 0pt 0.75pt;border-top:1pt solid #808080 ;border-left:1pt solid #808080 ;border-bottom:1pt solid #808080 ;border-right:1pt solid #808080 ;line-height:2.25pt;text-align:center;font-family:Calibri;font-size: 12pt">
			<a name="FIS_EXHIBIT_INDEX"></a><font style="display: inline;font-family:Times New Roman;font-size:12pt;">&nbsp;</font>
		</p>
		<p style="margin:11.25pt 0pt 0pt;line-height:100%;text-align:center;font-family:Calibri;font-size: 10pt">
			<font style="display: inline;font-family:Times New Roman;font-weight:bold;font-size:10pt;">EXHIBIT INDEX</font>
		</p>
		<p style="margin:0pt;line-height:normal;font-family:Calibri;font-size: 11pt">
			<font style="display: inline;">&nbsp;</font>
		</p>
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						<font style="display: inline;font-size:8pt;">&nbsp;</font></p>
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					<p style="margin:0pt 0pt 10pt;font-family:Calibri;line-height:115%;height:1.00pt;overflow:hidden;font-size: 11pt">
						&nbsp;</p>
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					<p style="margin:0pt 0pt 10pt;font-family:Calibri;line-height:115%;height:1.00pt;overflow:hidden;font-size: 11pt">
						&nbsp;</p>
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					<p style="margin:0pt 0pt 10pt;font-family:Calibri;line-height:115%;font-size: 8pt">
						<font style="display: inline;font-family:Times New Roman;font-size:8pt;text-decoration:underline;">Exhibit No.</font></p>
				</td>
				<td valign="top" style="width:18.00pt;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;border-right:1pt none #D9D9D9 ;padding:0pt 6.5pt;">
					<p style="margin:0pt 0pt 10pt;font-family:Calibri;line-height:115%;font-size: 11pt">
						&nbsp;</p>
				</td>
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					<p style="margin:0pt 0pt 10pt;font-family:Calibri;line-height:115%;font-size: 8pt">
						<font style="display: inline;font-family:Times New Roman;font-size:8pt;text-decoration:underline;">Description</font></p>
				</td>
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					<p style="margin:0pt 0pt 10pt;font-family:Calibri;line-height:115%;font-size: 10pt">
						<font style="display: inline;font-family:Times New Roman;font-size:10pt;">99.1</font></p>
				</td>
				<td valign="top" style="width:18.00pt;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;border-right:1pt none #D9D9D9 ;padding:0pt 6.5pt;">
					<p style="margin:0pt 0pt 10pt;font-family:Calibri;line-height:115%;font-size: 11pt">
						&nbsp;</p>
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					<p style="margin:0pt 0pt 10pt;font-family:Calibri;line-height:115%;font-size: 10pt">
						<font style="display: inline;font-family:Times New Roman;font-size:10pt;">Press Release dated September 25, 2013 titled &#x201C;Pacific Biosciences Announces Agreement with Roche Diagnostics To Develop and Supply DNA Sequencing-Based Products for Clinical Diagnostics.&#x201D;</font></p>
				</td>
			</tr>
		</table></div>
		<p style="margin:0pt;line-height:normal;font-family:Calibri;font-size: 11pt">
			<font style="display: inline;">&nbsp;</font>
		</p>
		<p><font size="1"> </font></p><hr size="3" style="color:#999999" width="100%" align="center"></hr>
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87b95e0bc3a7467
UNITED STATES
SECURITIES AND EXCHANGE COMMISSION
Washington, DC 20549
FORM 8-K
CURRENT REPORT
Pursuant to Section 13 or 15(d) of
The Securities Exchange Act of 1934
Date of Report (Date of earliest event reported)
September 2
3
, 2013
Pacific Biosciences of California, Inc.
(Exact name of registrant as specified in its charter)
Delaware
001-34899
16-1590339
(State or other jurisdiction
of incorporation)
(Commission
File Number)
(IRS Employer
Identification No.)
1380 Willow Road
Menlo Park, California 94025
(Address of principal executive offices, including zip code)
(650) 521-8000
(Registrant's telephone number, including area code)
(Former name or former address, if changed since last report)
Check the appropriate box below if the Form 8-K filing is intended to simultaneously satisfy the filing obligation of the registrant under any of the following provisions (see General Instruction A.2):
¨
Written communications pursuant to Rule 425 under the Securities Act (17 CFR 230.425)
¨
Soliciting material pursuant to Rule 14a-12 under the Exchange Act (17 CFR 240.14a-12)
¨
Pre-commencement communications pursuant to Rule 14d-2(b) under the Exchange Act (17 CFR 240.14d-2(b))
¨
Pre-commencement communications pursuant to Rule 13e-4(c) under the Exchange Act (17 CFR 240.13e-4(c))
ITEM 1.01.
ENTRY INTO A MATERIAL DEFINITIVE AGREEMENT.
On September 2
3
, 2013 Pacific Biosciences of California, Inc. (the "Company") entered into a Development, Commercialization and License Agreement (the "Agreement") with F. Hoffman-La Roche Ltd ("Roche"), pursuant to which the Company: (i)
will
develop diagnostic products for clinical use including sequencing systems and consumables based on the Company's proprietary Single Molecule, Real-Time (SMRT®) technology; (ii)
has
grant
ed
to Roche an exclusive right to commercialize, and an exclusive license to sell, the developed diagnostic products for clinical use, the exclusivity of which is contingent on achieving sales minimums to be established in the future and contingent on Roche not selling
for clinical use
a
ny new
sequencing instrument that competes with any diagnostic instrument system developed under the Agreement
; and (iii)
will
manufacture and supply certain products
intended
for clinical use as the exclusive supplier to Roche.
The Company will receive up to $75 million from Roche comprised of a non-refundable up-front payment of $35 million and up to an additional $40 million based upon the achievement of development milestones
.
The Agreement has an initial term of thirteen years and provisions allowing Roche 5-year renewals, contingent on Roche meeting sales minimums.
Roche's
exclusive right to commercialize and exclusive license to sell
,
servic
e, and provide services using
the developed diagnostic products is limited to
nucleic acid sequencing for medical management of a human being and quality control or testing of human blood or tissue for transfusion or blood banking, human bone marrow transplantation or banking, or human tis
sue typing for transplantation.
All other applications and uses are specifically excluded.
The Company retains the rights to all other applications and uses and will continue to market its current and future products.
ITEM 7.01.
REGULATION FD DISCLOSURE.
On September 25, 20
1
3 Pacific Biosciences of California, Inc. (the "Company") issued a press release announcing a Development, Commercialization and License Agreement with Roche Diagnostics, a division of F. Hoffman-La Roche Ltd.
A copy of the Company's press release is furnished as Exhibit 99.1 hereto.
The information in Item 7.01 of this Current Report on Form 8-K, including the information in Exhibit 99.1 hereto, is furnished pursuant to Item 7.01 of Form 8-K and shall not be deemed "filed" for any purpose, including for the purposes of Section 18 of the Exchange Act, or otherwise subject to the liabilities of that Section. The information in Item 7.01 of this Current Report on Form 8-K, including the information in Exhibit 99.1 hereto, shall not be deemed incorporated by reference into any filing under the Securities Act, or the Exchange Act regardless of any general incorporation language in such filing.
ITEM 9.01.
FINANCIAL STATEMENTS AND EXHIBITS.
(d)
Exhibits.
99.1
Press Release dated September 25, 2013 titled "Pacific Biosciences Announces Agreement with Roche Diagnostics To Develop and Supply DNA Sequencing-Based Products for Clinical Diagnostics."
SIGNATURE
Pursuant to the requirements of the Securities Exchange Act of 1934, the registrant has duly caused this report to be signed on its behalf by the undersigned hereunto duly authorized.
Pacific Biosciences of California, Inc.
By:
/s/    Brian B. Dow
Brian B. Dow
Vice President and Principal Accounting Officer
Date: September 25, 2013
EXHIBIT INDEX
Exhibit No.
Description
99.1
Press Release dated September 25, 2013 titled "Pacific Biosciences Announces Agreement with Roche Diagnostics To Develop and Supply DNA Sequencing-Based Products for Clinical Diagnostics."