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<P STYLE="font: 18pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>UNITED STATES</B></P>

<P STYLE="font: 18pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>SECURITIES AND EXCHANGE COMMISSION</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>Washington, DC 20549</B></P>

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<P STYLE="font: 18pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>FORM&nbsp;8-K</B>&nbsp;</P>



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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>CURRENT REPORT</B></P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>PURSUANT TO SECTION&nbsp;13 OR 15(d)&nbsp;OF
THE</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>SECURITIES EXCHANGE ACT OF 1934</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">Date of Report (Date of earliest event reported):<B>
October&nbsp;30, 2015</B></P>

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<P STYLE="font: 18pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>Edge Therapeutics, Inc. </B></P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0pt 6pt; text-align: center">(Exact name of Registrant as specified in
its charter)</P>

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    <TD STYLE="width: 33%; font-size: 10pt; text-align: center"><FONT STYLE="font-size: 10pt"><B>Delaware</B></FONT></TD>
    <TD STYLE="vertical-align: bottom; width: 1%; font-size: 10pt">&nbsp;</TD>
    <TD STYLE="width: 33%; font-size: 10pt; text-align: center"><FONT STYLE="font-size: 10pt"><B>001-37568</B></FONT></TD>
    <TD STYLE="vertical-align: bottom; width: 1%; font-size: 10pt">&nbsp;</TD>
    <TD STYLE="vertical-align: top; width: 32%; font-size: 10pt; text-align: center"><FONT STYLE="font-size: 10pt"><B>26-4231384</B></FONT></TD></TR>
<TR>
    <TD>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">(State or Other Jurisdiction</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">of
Incorporation or Organization)</P></TD>
    <TD STYLE="vertical-align: bottom; font-size: 10pt">&nbsp;</TD>
    <TD>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">(Commission&nbsp;</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">File Number)</P></TD>
    <TD STYLE="vertical-align: bottom; font-size: 10pt">&nbsp;</TD>
    <TD STYLE="vertical-align: top">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">(I.R.S. Employer</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">Identification No.)</P></TD></TR>
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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>200 Connell Drive, Suite 1600</B>&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>Berkeley Heights, NJ 07922&nbsp;</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>(800) 208-3343</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">(Address,&nbsp;Including Zip Code, and Telephone
Number,&nbsp;Including Area Code, of Registrant&#8217;s Principal Executive Offices)</P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>Not Applicable</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">(Former name or former address, if changed
since last report)</P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Check the appropriate box below if the Form&nbsp;8-K filing
is intended to simultaneously satisfy the filing obligation of the registrant under any of the following provisions:</P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><FONT STYLE="font-family: Wingdings">&#111;</FONT>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;
Written communications pursuant to Rule&nbsp;425 under the Securities Act (17 CFR 230.425)</P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><FONT STYLE="font-family: Wingdings">&#111;</FONT>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;
Soliciting material pursuant to Rule&nbsp;14a-12 under the Exchange Act (17CFR 240.14a-12)</P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><FONT STYLE="font-family: Wingdings">&#111;</FONT>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;
Pre-commencement communications pursuant to Rule&nbsp;14d-2(b)&nbsp;under the Exchange Act (17 CFR 240.14d-2(b))</P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><FONT STYLE="font-family: Wingdings">&#111;</FONT>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;
Pre-commencement communications pursuant to Rule&nbsp;13e-4(c)&nbsp;under the Exchange Act (17 CFR 240.13e-4(c))</P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B></B></P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B>&nbsp;Item 5.02 &nbsp;&nbsp;Departure of Directors or Certain
Officers; Election of Directors; Appointment of Certain Officers; Compensatory Arrangements of Certain Officers.</B></P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt"><U>(e)</U></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><U>Appointment of W. Bradford Middlekauff as Senior Vice President,
General Counsel and Secretary</U></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">On October 30, 2015, the Board of Directors (the &#8220;Board&#8221;)
of Edge Therapeutics, Inc. (the &#8220;Company&#8221;) appointed W. Bradford Middlekauff to the position of Senior Vice President,
General Counsel and Secretary, effective immediately.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">In connection with his appointment, the Company entered into
an Executive Employment Agreement with Mr. Middlekauff (the &quot;Employment Agreement&quot;) whereby Mr. Middlekauff will serve
as the Company's Senior Vice President, General Counsel and Secretary. The Employment Agreement is effective as of October 30,
2015 and has an indefinite term. Under the Employment Agreement, Mr. Middlekauff will receive an annual salary of $305,000. Mr.
Middlekauff&#8217;s annual salary is subject to adjustment at the discretion of the Board.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Mr. Middlekauff is eligible for an annual target discretionary
bonus of up to 35% of his base salary based upon the achievement of financial and other performance criteria, as determined by
the Board or the Compensation Committee of the Board (the &#8220;Compensation Committee&#8221;), provided that Mr. Middlekauff
remains employed with the Company on the last day of the relevant performance period.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Under the&nbsp;Employment Agreement, Mr.&nbsp;Middlekauff
is also entitled to participate in the employee benefit plans, policies, practices and arrangements and is eligible for the
same number of holidays and vacation days, in each case as are generally allowed to other similarly situated executives of
the Company.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">In the event that Mr. Middlekauff's employment is terminated
by the Company other than for Cause, death or Disability or upon his resignation for Good Reason (as these terms are defined in
the Employment Agreement), Mr. Middlekauff will be entitled to certain severance payments and benefits, including an amount equal
to his yearly base salary plus any accrued but unpaid bonus with respect to the year immediately preceding the Date of Termination
(as defined in the Employment Agreement), plus 12 months of COBRA premium reimbursement in exchange for his execution of a release
of claims against the Company.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">In the event of a Change of Control (as defined in
the Employment Agreement), the Employment Agreement provides severance payments upon certain employment terminations that
occur in connection with such Change in Control. If Mr. Middlekauff terminates his employment for Good Reason within 12
months following a Change in Control or if the Company terminates Mr. Middlekauff&#8217;s employment other than for Cause (i)
within the 60-day period prior to a Change in Control or (ii) within the 12-month period following a Change in Control, then,
in each case, Mr. Middlekauff would be entitled to receive the same severance benefits as if such termination was not
in connection with a Change in Control. In addition, immediately upon a Change  of Control, Mr. Middlekauff would be entitled
to accelerated vesting of all unvested equity awards (with performance-based awards to vest at not less than target),
regardless of whether or not his employment continues with the Company.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">The foregoing summary of the Employment Agreement does not purport
to be complete and is subject to, and qualified in its entirety by, the full text of the Employment Agreement, which is attached
as Exhibit 10.1 to this Current Report on Form 8-K and incorporated herein by reference.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B>Item 8.01&#9;&nbsp;&nbsp;Other Events.</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">On November 5, 2015, the Company issued a press release announcing
the appointment of Mr. Middlekauff as Senior Vice President, General Counsel and Secretary. A copy of the press release is filed
herewith as Exhibit&nbsp;99.1.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"></P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B>Item 9.01.&#9;&nbsp;&nbsp;Financial Statements and Exhibits</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

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<TR STYLE="vertical-align: bottom">
    <TD STYLE="width: 10%; border-bottom: black 1pt solid"><FONT STYLE="font-size: 10pt"><B>Exhibit</B></FONT><BR>
<FONT STYLE="font-size: 10pt"><B>Number</B></FONT></TD>
    <TD STYLE="width: 2%; text-align: center">&nbsp;</TD>
    <TD STYLE="width: 88%; border-bottom: black 1pt solid; text-align: center"><FONT STYLE="font-size: 10pt"><B>Description</B></FONT></TD></TR>
</TABLE>
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<TR STYLE="vertical-align: top">
    <TD STYLE="width: 10%"><FONT STYLE="font-size: 10pt">10.1</FONT></TD>
    <TD STYLE="width: 2%">&nbsp;</TD>
    <TD STYLE="width: 88%"><FONT STYLE="font-size: 10pt">Executive Employment Agreement by and between W. Bradford Middlekauff and the Company entered into as of October 30, 2015.</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD><FONT STYLE="font-size: 10pt">99.1</FONT></TD>
    <TD>&nbsp;</TD>
    <TD><FONT STYLE="font-size: 10pt">Press release dated November 5, 2015.</FONT></TD></TR>
</TABLE>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center"><B>SIGNATURE</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 24.5pt">Pursuant to the requirements of the Securities
Exchange Act of 1934, as amended, the Registrant has duly caused this report to be signed on its behalf by the undersigned hereunto
duly authorized.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 24.5pt">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
<TR STYLE="vertical-align: top">
    <TD><FONT STYLE="font-size: 10pt">Dated: November 5, 2015</FONT></TD>
    <TD COLSPAN="3"><FONT STYLE="font-size: 10pt">Edge Therapeutics, Inc. </FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD COLSPAN="3">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="width: 52%">&nbsp;</TD>
    <TD STYLE="width: 3%">&nbsp;</TD>
    <TD STYLE="width: 3%"><FONT STYLE="font-size: 10pt">By:</FONT></TD>
    <TD STYLE="width: 42%; border-bottom: Black 1pt solid"><FONT STYLE="font-size: 10pt">/s/ Andrew J. Einhorn</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD><FONT STYLE="font-size: 10pt">Name: Andrew J. Einhorn </FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD><FONT STYLE="font-size: 10pt">Title: Chief Financial Officer</FONT></TD></TR>
</TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>




<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"></P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center"><B>EXHIBIT INDEX</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
<TR STYLE="vertical-align: bottom">
    <TD STYLE="border-bottom: Black 1pt solid; font-weight: bold">Exhibit<BR> Number</TD>
    <TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
    <TD STYLE="font-weight: bold; border-bottom: Black 1pt solid; text-align: center">Description</TD>
    </TR>
<TR STYLE="text-align: left; vertical-align: top">
    <TD STYLE="width: 10%">10.1</TD>
    <TD STYLE="width: 2%">&nbsp;</TD>
    <TD STYLE="width: 88%">Executive Employment Agreement by and between W. Bradford Middlekauff and the Company entered into as of October 30, 2015.</TD></TR>
<TR STYLE="vertical-align: bottom">
    <TD STYLE="text-align: left">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD STYLE="text-align: left">&nbsp;</TD></TR>
<TR STYLE="text-align: left; vertical-align: top">
    <TD>99.1</TD>
    <TD>&nbsp;</TD>
    <TD>Press release dated November 5, 2015.</TD></TR>
</TABLE>




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UNITED STATES
SECURITIES AND EXCHANGE COMMISSION
Washington, DC 20549
FORM 8-K
CURRENT REPORT
PURSUANT TO SECTION 13 OR 15(d) OF
THE
SECURITIES EXCHANGE ACT OF 1934
Date of Report (Date of earliest event reported):
October 30, 2015
Edge Therapeutics, Inc.
(Exact name of Registrant as specified in
its charter)
Delaware
001-37568
26-4231384
(State or Other Jurisdiction
of
Incorporation or Organization)
(Commission
File Number)
(I.R.S. Employer
Identification No.)
200 Connell Drive, Suite 1600
Berkeley Heights, NJ 07922
(800) 208-3343
(Address, Including Zip Code, and Telephone
Number, Including Area Code, of Registrant's Principal Executive Offices)
Not Applicable
(Former name or former address, if changed
since last report)
Check the appropriate box below if the Form 8-K filing
is intended to simultaneously satisfy the filing obligation of the registrant under any of the following provisions:
o
Written communications pursuant to Rule 425 under the Securities Act (17 CFR 230.425)
o
Soliciting material pursuant to Rule 14a-12 under the Exchange Act (17CFR 240.14a-12)
o
Pre-commencement communications pursuant to Rule 14d-2(b) under the Exchange Act (17 CFR 240.14d-2(b))
o
Pre-commencement communications pursuant to Rule 13e-4(c) under the Exchange Act (17 CFR 240.13e-4(c))
Item 5.02   Departure of Directors or Certain
Officers; Election of Directors; Appointment of Certain Officers; Compensatory Arrangements of Certain Officers.
(e)
Appointment of W. Bradford Middlekauff as Senior Vice President,
General Counsel and Secretary
On October 30, 2015, the Board of Directors (the "Board")
of Edge Therapeutics, Inc. (the "Company") appointed W. Bradford Middlekauff to the position of Senior Vice President,
General Counsel and Secretary, effective immediately.
In connection with his appointment, the Company entered into
an Executive Employment Agreement with Mr. Middlekauff (the "Employment Agreement") whereby Mr. Middlekauff will serve
as the Company's Senior Vice President, General Counsel and Secretary. The Employment Agreement is effective as of October 30,
2015 and has an indefinite term. Under the Employment Agreement, Mr. Middlekauff will receive an annual salary of $305,000. Mr.
Middlekauff's annual salary is subject to adjustment at the discretion of the Board.
Mr. Middlekauff is eligible for an annual target discretionary
bonus of up to 35% of his base salary based upon the achievement of financial and other performance criteria, as determined by
the Board or the Compensation Committee of the Board (the "Compensation Committee"), provided that Mr. Middlekauff
remains employed with the Company on the last day of the relevant performance period.
Under the Employment Agreement, Mr. Middlekauff
is also entitled to participate in the employee benefit plans, policies, practices and arrangements and is eligible for the
same number of holidays and vacation days, in each case as are generally allowed to other similarly situated executives of
the Company.
In the event that Mr. Middlekauff's employment is terminated
by the Company other than for Cause, death or Disability or upon his resignation for Good Reason (as these terms are defined in
the Employment Agreement), Mr. Middlekauff will be entitled to certain severance payments and benefits, including an amount equal
to his yearly base salary plus any accrued but unpaid bonus with respect to the year immediately preceding the Date of Termination
(as defined in the Employment Agreement), plus 12 months of COBRA premium reimbursement in exchange for his execution of a release
of claims against the Company.
In the event of a Change of Control (as defined in
the Employment Agreement), the Employment Agreement provides severance payments upon certain employment terminations that
occur in connection with such Change in Control. If Mr. Middlekauff terminates his employment for Good Reason within 12
months following a Change in Control or if the Company terminates Mr. Middlekauff's employment other than for Cause (i)
within the 60-day period prior to a Change in Control or (ii) within the 12-month period following a Change in Control, then,
in each case, Mr. Middlekauff would be entitled to receive the same severance benefits as if such termination was not
in connection with a Change in Control. In addition, immediately upon a Change  of Control, Mr. Middlekauff would be entitled
to accelerated vesting of all unvested equity awards (with performance-based awards to vest at not less than target),
regardless of whether or not his employment continues with the Company.
The foregoing summary of the Employment Agreement does not purport
to be complete and is subject to, and qualified in its entirety by, the full text of the Employment Agreement, which is attached
as Exhibit 10.1 to this Current Report on Form 8-K and incorporated herein by reference.
Item 8.01	  Other Events.
On November 5, 2015, the Company issued a press release announcing
the appointment of Mr. Middlekauff as Senior Vice President, General Counsel and Secretary. A copy of the press release is filed
herewith as Exhibit 99.1.
Item 9.01.	  Financial Statements and Exhibits
Exhibit
Number
Description
10.1
Executive Employment Agreement by and between W. Bradford Middlekauff and the Company entered into as of October 30, 2015.
99.1
Press release dated November 5, 2015.
SIGNATURE
Pursuant to the requirements of the Securities
Exchange Act of 1934, as amended, the Registrant has duly caused this report to be signed on its behalf by the undersigned hereunto
duly authorized.
Dated: November 5, 2015
Edge Therapeutics, Inc.
By:
/s/ Andrew J. Einhorn
Name: Andrew J. Einhorn
Title: Chief Financial Officer
EXHIBIT INDEX
Exhibit
Number
Description
10.1
Executive Employment Agreement by and between W. Bradford Middlekauff and the Company entered into as of October 30, 2015.
99.1
Press release dated November 5, 2015.