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<p style="text-align:center;margin-bottom:0pt;margin-top:0pt;margin-left:0%;margin-right:0%;text-indent:0%;font-size:16pt;;"><font style="font-weight:bold;font-size:16pt;font-family:Times New Roman;font-style:normal;text-transform:none;font-variant: normal;">UNITED STATES</font></p><p style="text-align:center;margin-bottom:0pt;margin-top:0pt;margin-left:0%;margin-right:0%;text-indent:0%;font-size:16pt;;"><font style="font-weight:bold;font-size:16pt;font-family:Times New Roman;font-style:normal;text-transform:none;font-variant: normal;">SECURITIES AND EXCHANGE COMMISSION</font></p><p style="text-align:center;margin-bottom:0pt;margin-top:0pt;margin-left:0%;margin-right:0%;text-indent:0%;font-size:10pt;;"><font style="font-weight:bold;font-size:10pt;font-family:Times New Roman;font-style:normal;text-transform:none;font-variant: normal;">Washington, D.C. 20549</font></p><p style="text-align:center;margin-bottom:0pt;margin-top:0pt;margin-left:0%;margin-right:0%;text-indent:0%;font-size:10pt;;"><font style="font-size:10pt;font-family:Times New Roman;font-weight:normal;font-style:normal;text-transform:none;font-variant: normal;">&#160;</font></p><p style="text-align:center;margin-bottom:0pt;margin-top:0pt;margin-left:0%;margin-right:0%;text-indent:0%;font-size:16pt;;"><font style="font-weight:bold;font-size:16pt;font-family:Times New Roman;font-style:normal;text-transform:none;font-variant: normal;">FORM 8-K</font></p><p style="text-align:center;margin-bottom:0pt;margin-top:0pt;margin-left:0%;margin-right:0%;text-indent:0%;font-size:10pt;;"><font style="font-weight:bold;font-size:10pt;font-family:Times New Roman;font-style:normal;text-transform:none;font-variant: normal;">CURRENT REPORT</font></p><p style="text-align:center;margin-bottom:0pt;margin-top:0pt;margin-left:0%;margin-right:0%;text-indent:0%;font-size:10pt;;"><font style="font-weight:bold;font-size:10pt;font-family:Times New Roman;font-style:normal;text-transform:none;font-variant: normal;">Pursuant to Section 13 or 15(d)</font></p><p style="text-align:center;margin-bottom:0pt;margin-top:0pt;margin-left:0%;margin-right:0%;text-indent:0%;font-size:10pt;;"><font style="font-weight:bold;font-size:10pt;font-family:Times New Roman;font-style:normal;text-transform:none;font-variant: normal;">of the Securities Exchange Act of 1934</font></p><p style="text-align:center;margin-bottom:0pt;margin-top:0pt;margin-left:0%;margin-right:0%;text-indent:0%;font-size:10pt;;"><font style="font-size:10pt;font-family:Times New Roman;font-weight:normal;font-style:normal;text-transform:none;font-variant: normal;">&#160;</font></p><p style="text-align:center;margin-bottom:0pt;margin-top:0pt;margin-left:0%;margin-right:0%;text-indent:0%;font-size:10pt;;"><font style="font-size:10pt;font-family:Times New Roman;font-weight:normal;font-style:normal;text-transform:none;font-variant: normal;">Date of Report (Date of earliest event reported): March 14, 2014</font></p><p style="text-align:center;margin-bottom:0pt;margin-top:0pt;margin-left:0%;margin-right:0%;text-indent:0%;font-size:10pt;;">&nbsp;</p><p style="text-align:center;border-bottom:Solid 1pt;margin-bottom:0pt;margin-top:0pt;margin-left:0%;margin-right:0%;text-indent:0%;font-size:16pt;;"><font style="font-weight:bold;font-size:16pt;font-family:Times New Roman;font-style:normal;text-transform:none;font-variant: normal;">Portola Pharmaceuticals, Inc.</font></p><p style="text-align:center;margin-bottom:0pt;margin-top:0pt;margin-left:0%;margin-right:0%;text-indent:0%;font-size:10pt;;"><font style="font-size:10pt;font-family:Times New Roman;font-weight:normal;font-style:normal;text-transform:none;font-variant: normal;">(Exact name of registrant as specified in its charter)</font></p><p style="text-align:center;margin-bottom:0pt;margin-top:0pt;margin-left:0%;margin-right:0%;text-indent:0%;font-size:10pt;;"><font style="font-size:10pt;font-family:Times New Roman;font-weight:normal;font-style:normal;text-transform:none;font-variant: normal;">&#160;</font></p><div>
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<td valign="top" style="padding-left:0 pt;padding-Right:0 pt;padding-Top:0 pt;width:2%; border-bottom:solid 1pt transparent;"><p style="margin-bottom:0pt;margin-top:0pt;margin-left:0pt;;margin-right:0%;text-indent:0pt;;font-size:10pt;;"><font style="font-size:10pt;font-family:Times New Roman;font-weight:normal;font-style:normal;text-transform:none;font-variant: normal;">&#160;</font></p></td>
<td valign="top" style="padding-left:0 pt;padding-Right:0 pt;padding-Top:0 pt;padding-Bottom:1 pt;width:32%; border-bottom:solid 1pt #000000;"><p style="text-align:center;margin-bottom:0pt;margin-top:0pt;margin-left:0pt;;margin-right:0%;text-indent:0pt;;font-weight:bold;;font-size:10pt;;"><font style="font-weight:bold;font-size:10pt;font-family:Times New Roman;font-style:normal;text-transform:none;font-variant: normal;">001-35935</font></a></p></td>
<td valign="top" style="padding-left:0 pt;padding-Right:0 pt;padding-Top:0 pt;width:2%; border-bottom:solid 1pt transparent;"><p style="margin-bottom:0pt;margin-top:0pt;margin-left:0pt;;margin-right:0%;text-indent:0pt;;font-size:10pt;;"><font style="font-size:10pt;font-family:Times New Roman;font-weight:normal;font-style:normal;text-transform:none;font-variant: normal;">&#160;</font></p></td>
<td valign="top" style="width:32%; border-bottom:solid 1pt #000000;"><p style="text-align:center;margin-bottom:0pt;margin-top:0pt;margin-left:0pt;;margin-right:0%;text-indent:0pt;;font-size:10pt;;"><font style="font-weight:bold;font-size:10pt;font-family:Times New Roman;font-style:normal;text-transform:none;font-variant: normal;">20-0216859</font></p></td>
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<td valign="top" style="width:auto;"><p style="text-align:center;margin-bottom:0pt;margin-top:0pt;margin-left:0pt;;margin-right:0%;text-indent:0pt;;font-size:10pt;;"><font style="font-size:10pt;font-family:Times New Roman;font-weight:normal;font-style:normal;text-transform:none;font-variant: normal;">(State or other jurisdiction</font></p></td>
<td valign="top" style="width:auto;"><p style="margin-bottom:0pt;margin-top:0pt;margin-left:0pt;;margin-right:0%;text-indent:0pt;;font-size:10pt;;"><font style="font-size:10pt;font-family:Times New Roman;font-weight:normal;font-style:normal;text-transform:none;font-variant: normal;">&#160;</font></p></td>
<td valign="top" style="width:auto;"><p style="text-align:center;margin-bottom:0pt;margin-top:0pt;margin-left:0pt;;margin-right:0%;text-indent:0pt;;font-size:10pt;;"><font style="font-size:10pt;font-family:Times New Roman;font-weight:normal;font-style:normal;text-transform:none;font-variant: normal;">(Commission File Number)</font></p></td>
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<td valign="top" style="width:auto;"><p style="text-align:center;margin-bottom:0pt;margin-top:0pt;margin-left:0pt;;margin-right:0%;text-indent:0pt;;font-size:10pt;;"><font style="font-size:10pt;font-family:Times New Roman;font-weight:normal;font-style:normal;text-transform:none;font-variant: normal;">(IRS Employer Identification No.)</font></p></td>
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<td valign="top" style="width:auto;"><p style="text-align:center;margin-bottom:0pt;margin-top:0pt;margin-left:0pt;;margin-right:0%;text-indent:0pt;;font-size:10pt;;"><font style="font-size:10pt;font-family:Times New Roman;font-weight:normal;font-style:normal;text-transform:none;font-variant: normal;">of incorporation)</font></p></td>
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<td valign="top" style="width:auto;"><p style="text-align:center;margin-bottom:0pt;margin-top:0pt;margin-left:0pt;;margin-right:0%;text-indent:0pt;;font-size:10pt;;"><font style="font-size:10pt;font-family:Times New Roman;font-weight:normal;font-style:normal;text-transform:none;font-variant: normal;">&#160;</font></p></td>
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<td valign="top" style="width:auto;"><p style="text-align:center;margin-bottom:0pt;margin-top:0pt;margin-left:0pt;;margin-right:0%;text-indent:0pt;;font-size:10pt;;"><font style="font-size:10pt;font-family:Times New Roman;font-weight:normal;font-style:normal;text-transform:none;font-variant: normal;">&#160;</font></p></td>
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</table></div><p style="margin-bottom:0pt;margin-top:0pt;margin-left:0%;margin-right:0%;text-indent:0%;font-size:10pt;;"><font style="font-size:10pt;font-family:Times New Roman;font-weight:normal;font-style:normal;text-transform:none;font-variant: normal;">&#160;</font></p><div>
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<td valign="bottom" style="width:60%; border-bottom:solid 1pt #000000;"><p style="text-align:center;margin-bottom:0pt;margin-top:0pt;margin-left:0pt;;margin-right:0%;text-indent:0pt;;font-family:;font-weight:bold;;font-size:10pt;;"><font style="font-weight:bold;font-size:10pt;font-family:Times New Roman;font-style:normal;text-transform:none;font-variant: normal;">270 E. Grand Avenue</font></p><p style="text-align:center;margin-bottom:0pt;margin-top:0pt;margin-left:0pt;;margin-right:0%;text-indent:0pt;;font-size:10pt;;"><font style="font-weight:bold;font-size:10pt;font-family:Times New Roman;font-style:normal;text-transform:none;font-variant: normal;">South San Francisco, California</font></p></td>
<td valign="top" style="padding-left:0 pt;padding-Right:0 pt;padding-Top:0 pt;width:5%; border-bottom:solid 1pt transparent;"><p style="margin-bottom:0pt;margin-top:0pt;margin-left:0pt;;margin-right:0%;text-indent:0pt;;font-size:10pt;;"><font style="font-size:10pt;font-family:Times New Roman;font-weight:normal;font-style:normal;text-transform:none;font-variant: normal;">&#160;</font></p></td>
<td valign="bottom" style="width:35%; border-bottom:solid 1pt #000000;"><p style="text-align:center;margin-bottom:0pt;margin-top:0pt;margin-left:0pt;;margin-right:0%;text-indent:0pt;;font-size:10pt;;"><font style="font-weight:bold;font-size:10pt;font-family:Times New Roman;font-style:normal;text-transform:none;font-variant: normal;">94080</font></p></td>
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<td valign="top" style="width:auto;"><p style="text-align:center;margin-bottom:0pt;margin-top:0pt;margin-left:0pt;;margin-right:0%;text-indent:0pt;;font-size:10pt;;"><font style="font-size:10pt;font-family:Times New Roman;font-weight:normal;font-style:normal;text-transform:none;font-variant: normal;">(Address of principal executive offices)</font></p></td>
<td valign="top" style="width:auto;"><p style="margin-bottom:0pt;margin-top:0pt;margin-left:0pt;;margin-right:0%;text-indent:0pt;;font-size:10pt;;"><font style="font-size:10pt;font-family:Times New Roman;font-weight:normal;font-style:normal;text-transform:none;font-variant: normal;">&#160;</font></p></td>
<td valign="top" style="width:auto;"><p style="text-align:center;margin-bottom:0pt;margin-top:0pt;margin-left:0pt;;margin-right:0%;text-indent:0pt;;font-size:10pt;;"><font style="font-size:10pt;font-family:Times New Roman;font-weight:normal;font-style:normal;text-transform:none;font-variant: normal;">(Zip Code)</font></p></td>
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</table></div><p style="margin-bottom:0pt;margin-top:0pt;margin-left:0%;margin-right:0%;text-indent:0%;font-size:10pt;;"><font style="font-size:10pt;font-family:Times New Roman;font-weight:normal;font-style:normal;text-transform:none;font-variant: normal;">&#160;</font></p><p style="text-align:center;margin-bottom:0pt;margin-top:0pt;margin-left:0%;margin-right:0%;text-indent:0%;font-weight:bold;;font-size:10pt;;"><font style="font-weight:bold;font-size:10pt;font-family:Times New Roman;font-style:normal;text-transform:none;font-variant: normal;">Registrant&#8217;s telephone number, including area code: (650) 246-7300</font></p><p style="text-align:center;margin-bottom:0pt;margin-top:0pt;margin-left:0%;margin-right:0%;text-indent:0%;font-weight:bold;;font-size:10pt;;"><font style="font-weight:bold;font-size:10pt;font-family:Times New Roman;font-style:normal;text-transform:none;font-variant: normal;">&#160;</font></p><p 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style="font-size:10pt;font-family:'Wingdings';font-weight:normal;font-style:normal;text-transform:none;font-variant: normal;"><font style="font-size:10pt;font-family:'Wingdings'">&#168;</font></font><font style="font-size:10pt;font-family:Times New Roman;font-weight:normal;font-style:normal;text-transform:none;font-variant: normal;"></font><font style="color:#000000;font-size:10pt;font-family:Times New Roman;font-weight:normal;font-style:normal;text-transform:none;font-variant: normal;">Pre-commencement communications pursuant to Rule&#160;14d-2(b) under the Exchange Act (17 CFR 240.14d-2(b))</font></p><p style="margin-bottom:0pt;margin-top:0pt;margin-left:4.62%;margin-right:0%;text-indent:-4.62%;font-size:10pt;;"><font style="font-size:10pt;font-family:Times New Roman;font-weight:normal;font-style:normal;text-transform:none;font-variant: normal;">&#160;</font></p><p style="margin-bottom:0pt;margin-top:0pt;margin-left:0%;margin-right:0%;text-indent:0%;font-size:10pt;;"><font 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normal;">&#160;</font></p><p style="margin-bottom:10pt;margin-top:0pt;margin-left:0%;margin-right:0%;text-indent:0%;font-size:10pt;;">&nbsp;</p><p style="margin-bottom:0pt;margin-top:12pt;line-height:10pt;margin-left:0%;margin-right:0%;text-indent:0%;font-size:11pt;">&nbsp;</p>

<div style="width:100%;"><hr style="page-break-after:always"></div><p style="margin-bottom:0pt;margin-top:0pt;margin-left:0%;margin-right:0%;text-indent:0%;font-weight:bold;;font-size:10pt;;"><font style="font-weight:bold;font-size:10pt;font-family:Times New Roman;font-style:normal;text-transform:none;font-variant: normal;">Item 1.01 Entry into a Material Definitive Agreement.</font></p><p style="margin-bottom:0pt;margin-top:0pt;margin-left:0%;margin-right:0%;text-indent:0%;font-size:10pt;;">&nbsp;</p><p style="margin-bottom:0pt;margin-top:0pt;margin-left:0%;margin-right:0%;text-indent:0%;font-size:10pt;;"><font style="font-size:10pt;font-family:Times New Roman;font-weight:normal;font-style:normal;text-transform:none;font-variant: normal;">On March 14, 2014 Portola Pharmaceuticals, Inc. (the &#8220;Company&#8221;) entered into that certain Second Amendment to Lease (the &#8220;Amended Lease&#8221;), by and between the Company and Britannia Pointe Grand Limited Partnership (the &#8220;Landlord&#8221;).  The Amended Lease amended the terms of that certain Lease dated December 15, 2006 by and between the Company and the Landlord, as amended by that certain First Amendment to Lease dated May 21, 2010.&nbsp;&nbsp;</font></p><p style="margin-bottom:0pt;margin-top:0pt;margin-left:0%;margin-right:0%;text-indent:0%;font-size:10pt;;">&nbsp;</p><p style="margin-bottom:0pt;margin-top:0pt;margin-left:0%;margin-right:0%;text-indent:0%;font-size:10pt;;"><font style="font-size:10pt;font-family:Times New Roman;font-weight:normal;font-style:normal;text-transform:none;font-variant: normal;">The Amended Lease extends the term of the Company&#8217;s existing lease for its corporate headquarters from March 2015 to March 2020, with an early termination option by the Company in March 2018.&nbsp;&nbsp;The Amended Lease also increases the total amount of space leased by the Company by approximately 20 percent.&nbsp;&nbsp;The Amended Lease increases the Company&#8217;s monthly rent from approximately $140,000 per month to approximately $169,000 per month.&nbsp;&nbsp;The Amended Lease also includes a tenant improvement allowance paid by the Landlord of approximately $1.84 million.</font></p><p style="margin-bottom:0pt;margin-top:0pt;margin-left:0%;margin-right:0%;text-indent:0%;font-size:10pt;;">&nbsp;</p><p style="margin-bottom:0pt;margin-top:0pt;margin-left:0%;margin-right:0%;text-indent:0%;font-size:10pt;;"><font style="font-size:10pt;font-family:Times New Roman;font-weight:normal;font-style:normal;text-transform:none;font-variant: normal;">A copy of the Amended Lease is attached as Exhibit 10.22 and incorporated by reference herein.</font></p><p style="margin-bottom:0pt;margin-top:0pt;margin-left:0%;margin-right:0%;text-indent:0%;font-size:10pt;;">&nbsp;</p><p style="margin-bottom:0pt;margin-top:0pt;margin-left:0%;margin-right:0%;text-indent:0%;font-size:10pt;;">&nbsp;</p><p style="margin-bottom:0pt;margin-top:0pt;margin-left:0%;margin-right:0%;text-indent:0%;font-weight:bold;;font-size:10pt;;">&nbsp;</p><p style="margin-bottom:0pt;margin-top:0pt;margin-left:0%;margin-right:0%;text-indent:0%;font-size:10pt;;"><font style="font-weight:bold;font-size:10pt;font-family:Times New Roman;font-style:normal;text-transform:none;font-variant: normal;">Item&#160;9.01 Financial Statements and Exhibits</font></p><p style="margin-bottom:0pt;margin-top:0pt;margin-left:0%;margin-right:0%;text-indent:0%;font-size:10pt;;"><font style="font-size:10pt;font-family:Times New Roman;font-weight:normal;font-style:normal;text-transform:none;font-variant: normal;">&#160;</font></p><p style="margin-bottom:0pt;margin-top:0pt;margin-left:0%;margin-right:0%;text-indent:0%;font-size:10pt;;"><font style="font-size:10pt;font-family:Times New Roman;font-weight:normal;font-style:normal;text-transform:none;font-variant: normal;">(d)&#160;Exhibits</font></p><p style="margin-bottom:0pt;margin-top:0pt;margin-left:0%;margin-right:0%;text-indent:0%;font-size:10pt;;"><font style="font-size:10pt;font-family:Times New Roman;font-weight:normal;font-style:normal;text-transform:none;font-variant: normal;">&#160;</font></p><div align="left"><table border="0" cellspacing="0" cellpadding="0"  style="border-collapse:collapse; width:92.31%;margin-left:7.69%;margin-right:0%"><tr><td valign="top" style="width:7.69%;white-space:nowrap"><p style="margin-bottom:0pt;margin-top:0pt;font-size:10pt;;"><font style="font-size:10pt;font-family:Times New Roman;font-weight:normal;font-style:normal;text-transform:none;font-variant: normal;">10.22</font></p></td><td valign="top" style="width:92.31%;"><p style="margin-bottom:0pt;margin-top:0pt;font-size:10pt;;"><font style="font-size:10pt;font-family:Times New Roman;font-weight:normal;font-style:normal;text-transform:none;font-variant: normal;">Second Amendment to Lease made and entered into as of the 14<sup style="font-size:85%; vertical-align:top">th</sup> day of March 2014, by and between Portola Pharmaceuticals, Inc. and Britannia Pointe Grand Limited Partnership.</font></p></td></tr></table></div><p style="margin-bottom:0pt;margin-top:9pt;margin-left:0%;margin-right:0%;text-indent:0%;font-size:10pt;;">&nbsp;</p><p style="margin-bottom:0pt;margin-top:9pt;margin-left:0%;margin-right:0%;text-indent:0%;font-size:10pt;;">&nbsp;</p><p style="margin-bottom:0pt;margin-top:12pt;line-height:10pt;margin-left:0%;margin-right:0%;text-indent:0%;font-size:11pt;">&nbsp;</p>

<div style="width:100%;"><hr style="page-break-after:always"></div><p style="text-align:center;margin-bottom:12pt;margin-top:0pt;margin-left:0%;margin-right:0%;text-indent:0%;font-size:10pt;;"><font style="font-weight:bold;font-size:10pt;font-family:Times New Roman;font-style:normal;text-transform:none;font-variant: normal;">SIGNATURES</font></p><p style="margin-bottom:12pt;margin-top:0pt;margin-left:0%;margin-right:0%;text-indent:7.69%;font-size:10pt;;"><font style="font-size:10pt;font-family:Times New Roman;font-weight:normal;font-style:normal;text-transform:none;font-variant: normal;text-indent:7.69%">Pursuant to the requirements of the Securities Exchange Act of 1934, the Registrant has duly caused this report to be signed on its behalf by the undersigned hereunto duly authorized.</font></p><div align="left">
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<td valign="top" style="width:auto;"><p style="margin-bottom:0pt;margin-top:0pt;margin-left:0pt;;margin-right:0%;text-indent:0pt;;font-size:10pt;;"><font style="font-size:10pt;font-family:Times New Roman;font-weight:normal;font-style:normal;text-transform:none;font-variant: normal;">&#160;</font></p></td>
<td valign="top" style="width:auto;"><p style="margin-bottom:0pt;margin-top:0pt;margin-left:0pt;;margin-right:0%;text-indent:0pt;;font-size:10pt;;"><font style="font-size:10pt;font-family:Times New Roman;font-weight:normal;font-style:normal;text-transform:none;font-variant: normal;">&#160;</font></p></td>
<td colspan="3" valign="top" style="width:auto;"><p style="margin-bottom:0pt;margin-top:0pt;margin-left:0pt;;margin-right:0%;text-indent:0pt;;font-weight:bold;;font-size:10pt;;"><font style="font-weight:bold;font-size:10pt;font-family:Times New Roman;font-style:normal;text-transform:none;font-variant: normal;">Portola Pharmaceuticals, Inc.</font></p></td>
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<td valign="top" style="width:auto;"><p style="margin-bottom:0pt;margin-top:0pt;margin-left:0pt;;margin-right:0%;text-indent:0pt;;font-size:10pt;;"><font style="font-size:10pt;font-family:Times New Roman;font-weight:normal;font-style:normal;text-transform:none;font-variant: normal;">&#160;</font></p></td>
<td valign="top" style="width:auto;"><p style="margin-bottom:0pt;margin-top:0pt;margin-left:0pt;;margin-right:0%;text-indent:0pt;;font-size:10pt;;"><font style="font-size:10pt;font-family:Times New Roman;font-weight:normal;font-style:normal;text-transform:none;font-variant: normal;">&#160;</font></p></td>
<td colspan="3" valign="top" style="width:auto;"><p style="margin-bottom:0pt;margin-top:0pt;margin-left:0pt;;margin-right:0%;text-indent:0pt;;font-size:10pt;;"><font style="font-size:10pt;font-family:Times New Roman;font-weight:normal;font-style:normal;text-transform:none;font-variant: normal;">&#160;</font></p></td>
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<td valign="top" style="width:auto;"><p style="margin-bottom:0pt;margin-top:0pt;margin-left:0pt;;margin-right:0%;text-indent:0pt;;font-size:10pt;;"><font style="font-size:10pt;font-family:Times New Roman;font-weight:normal;font-style:normal;text-transform:none;font-variant: normal;">Dated: March 19, 2014</font></p></td>
<td valign="top" style="width:auto;"><p style="margin-bottom:0pt;margin-top:0pt;margin-left:0pt;;margin-right:0%;text-indent:0pt;;font-size:10pt;;"><font style="font-size:10pt;font-family:Times New Roman;font-weight:normal;font-style:normal;text-transform:none;font-variant: normal;">&#160;</font></p></td>
<td colspan="3" valign="top" style="width:auto;"><p style="margin-bottom:0pt;margin-top:0pt;margin-left:0pt;;margin-right:0%;text-indent:0pt;;font-size:10pt;;"><font style="font-size:10pt;font-family:Times New Roman;font-weight:normal;font-style:normal;text-transform:none;font-variant: normal;">&#160;</font></p></td>
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<td valign="top" style="width:43.86%; border-bottom:solid 1pt transparent;"><p style="margin-bottom:0pt;margin-top:0pt;margin-left:0pt;;margin-right:0%;text-indent:0pt;;font-size:10pt;;"><font style="font-size:10pt;font-family:Times New Roman;font-weight:normal;font-style:normal;text-transform:none;font-variant: normal;">&#160;</font></p></td>
<td valign="top" style="width:1.92%; border-bottom:solid 1pt transparent;"><p style="margin-bottom:0pt;margin-top:0pt;margin-left:0pt;;margin-right:0%;text-indent:0pt;;font-size:10pt;;"><font style="font-size:10pt;font-family:Times New Roman;font-weight:normal;font-style:normal;text-transform:none;font-variant: normal;">&#160;</font></p></td>
<td valign="top" style="width:3.4%; border-bottom:solid 1pt transparent;"><p style="margin-bottom:0pt;margin-top:0pt;margin-left:0pt;;margin-right:0%;text-indent:0pt;;font-size:10pt;;"><font style="font-size:10pt;font-family:Times New Roman;font-weight:normal;font-style:normal;text-transform:none;font-variant: normal;">By:</font></p></td>
<td valign="top" style="width:47.9%; border-bottom:solid 1pt #000000;"><p style="margin-bottom:0pt;margin-top:0pt;margin-left:0pt;;margin-right:0%;text-indent:0pt;;font-size:10pt;;"><font style="font-size:10pt;font-family:Times New Roman;font-weight:normal;font-style:normal;text-transform:none;font-variant: normal;"> /s/ Mardi C. Dier</font></p></td>
<td valign="top" style="width:2.92%; border-bottom:solid 1pt transparent;"><p style="margin-bottom:0pt;margin-top:0pt;margin-left:0pt;;margin-right:0%;text-indent:0pt;;font-size:10pt;;"><font style="font-size:10pt;font-family:Times New Roman;font-weight:normal;font-style:normal;text-transform:none;font-variant: normal;">&#160;</font></p></td>
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<td valign="top" style="width:auto;"><p style="margin-bottom:0pt;margin-top:0pt;margin-left:0pt;;margin-right:0%;text-indent:0pt;;font-size:10pt;;"><font style="font-size:10pt;font-family:Times New Roman;font-weight:normal;font-style:normal;text-transform:none;font-variant: normal;">&#160;</font></p></td>
<td valign="top" style="width:auto;"><p style="margin-bottom:0pt;margin-top:0pt;margin-left:0pt;;margin-right:0%;text-indent:0pt;;font-size:10pt;;"><font style="font-size:10pt;font-family:Times New Roman;font-weight:normal;font-style:normal;text-transform:none;font-variant: normal;">&#160;</font></p></td>
<td valign="top" style="width:auto;"><p style="margin-bottom:0pt;margin-top:0pt;margin-left:0pt;;margin-right:0%;text-indent:0pt;;font-size:10pt;;"><font style="font-size:10pt;font-family:Times New Roman;font-weight:normal;font-style:normal;text-transform:none;font-variant: normal;">&#160;</font></p></td>
<td colspan="2" valign="top" style="width:auto;"><p style="margin-bottom:0pt;margin-top:0pt;margin-left:0pt;;margin-right:0%;text-indent:0pt;;font-size:10pt;;"><font style="font-size:10pt;font-family:Times New Roman;font-weight:normal;font-style:normal;text-transform:none;font-variant: normal;">Mardi C. Dier</font></p></td>
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<td valign="top" style="width:auto;"><p style="margin-bottom:0pt;margin-top:0pt;margin-left:0pt;;margin-right:0%;text-indent:0pt;;font-size:10pt;;"><font style="font-size:10pt;font-family:Times New Roman;font-weight:normal;font-style:normal;text-transform:none;font-variant: normal;">&#160;</font></p></td>
<td valign="top" style="width:auto;"><p style="margin-bottom:0pt;margin-top:0pt;margin-left:0pt;;margin-right:0%;text-indent:0pt;;font-size:10pt;;"><font style="font-style:italic;;font-size:10pt;font-family:Times New Roman;font-weight:normal;text-transform:none;font-variant: normal;">&#160;</font></p></td>
<td valign="top" style="width:auto;"><p style="margin-bottom:0pt;margin-top:0pt;margin-left:0pt;;margin-right:0%;text-indent:0pt;;font-size:10pt;;"><font style="font-style:italic;;font-size:10pt;font-family:Times New Roman;font-weight:normal;text-transform:none;font-variant: normal;">&#160;</font></p></td>
<td colspan="2" valign="top" style="width:auto;"><p style="margin-bottom:0pt;margin-top:0pt;margin-left:0pt;;margin-right:0%;text-indent:0pt;;font-size:10pt;;"><font style="font-size:10pt;font-family:Times New Roman;font-weight:normal;font-style:normal;text-transform:none;font-variant: normal;">Executive Vice President and Chief Financial Officer</font></p></td>
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</table></div><p style="margin-bottom:0pt;margin-top:0pt;margin-left:53.85%;margin-right:0%;text-indent:1.92%;font-size:11pt;;">&nbsp;</p><p style="margin-bottom:0pt;margin-top:12pt;line-height:10pt;margin-left:0%;margin-right:0%;text-indent:0%;font-size:11pt;">&nbsp;</p>

<div style="width:100%;"><hr style="page-break-after:always"></div><p style="text-align:center;margin-bottom:0pt;margin-top:0pt;margin-left:0%;margin-right:0%;text-indent:0%;font-size:10pt;"><font style="font-weight:bold;font-size:10pt;font-family:Times New Roman;font-style:normal;text-transform:none;font-variant: normal;">EXHIBIT&#160;INDEX</font></p><p style="margin-bottom:0pt;margin-top:0pt;margin-left:0%;margin-right:0%;text-indent:0%;font-size:10pt;"><font style="font-size:10pt;font-family:Times New Roman;font-weight:normal;font-style:normal;text-transform:none;font-variant: normal;">&#160;</font></p><div align="left">
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<td valign="bottom" style="width:9.44%; border-bottom:solid 1pt #000000;"><p style="margin-bottom:0pt;margin-top:0pt;margin-left:0pt;;margin-right:0%;text-indent:0pt;;font-size:8pt;"><font style="font-weight:bold;font-size:8pt;font-family:Times New Roman;font-style:normal;text-transform:none;font-variant: normal;">Number</font></p></td>
<td valign="bottom" style="width:2.56%; border-bottom:solid 1pt transparent;"><p style="text-align:center;margin-bottom:0pt;margin-top:0pt;margin-left:0pt;;margin-right:0%;text-indent:0pt;;font-size:1pt;"><font style="font-weight:bold;font-size:1pt;font-family:Times New Roman;font-style:normal;text-transform:none;font-variant: normal;">&#160;</font></p></td>
<td valign="bottom" style="width:88%; border-bottom:solid 1pt #000000;"><p style="text-align:center;margin-bottom:0pt;margin-top:0pt;margin-left:0pt;;margin-right:0%;text-indent:0pt;;font-size:8pt;"><font style="font-weight:bold;font-size:8pt;font-family:Times New Roman;font-style:normal;text-transform:none;font-variant: normal;">Description&#160;of&#160;Document</font></p></td>
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<td valign="top" style="width:9.44%;"><p style="margin-bottom:0pt;margin-top:0pt;margin-left:0pt;;margin-right:0%;text-indent:0pt;;font-size:10pt;"><font style="font-size:10pt;font-family:Times New Roman;font-weight:normal;font-style:normal;text-transform:none;font-variant: normal;">10.22</font></p></td>
<td valign="bottom" style="width:2.56%;"><p style="margin-bottom:0pt;margin-top:0pt;margin-left:0pt;;margin-right:0%;text-indent:0pt;;font-size:1pt;"><font style="font-size:1pt;font-family:Times New Roman;font-weight:normal;font-style:normal;text-transform:none;font-variant: normal;">&#160;</font></p></td>
<td valign="top" style="width:88%;"><p style="margin-bottom:0pt;margin-top:0pt;margin-left:0pt;;margin-right:0%;text-indent:0pt;;font-size:10pt;;"><font style="font-size:10pt;font-family:Times New Roman;font-weight:normal;font-style:normal;text-transform:none;font-variant: normal;">Second Amendment to Lease made and entered into as of the 14th day of March 2014, by and between Portola Pharmaceuticals, Inc. and Britannia Pointe Grand Limited Partnership.</font></p><p style="margin-bottom:0pt;margin-top:0pt;margin-left:0pt;;margin-right:0%;text-indent:0pt;;font-size:10pt;;">&nbsp;</p><p style="margin-bottom:0pt;margin-top:0pt;margin-left:0pt;;margin-right:0%;text-indent:0pt;;font-size:11pt;">&nbsp;</p></td>
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UNITED STATES
SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 8-K
CURRENT REPORT
Pursuant to Section 13 or 15(d)
of the Securities Exchange Act of 1934
Date of Report (Date of earliest event reported): March 14, 2014
Portola Pharmaceuticals, Inc.
(Exact name of registrant as specified in its charter)
Delaware
001-35935
20-0216859
(State or other jurisdiction
(Commission File Number)
(IRS Employer Identification No.)
of incorporation)
270 E. Grand Avenue
South San Francisco, California
94080
(Address of principal executive offices)
(Zip Code)
Registrant's telephone number, including area code: (650) 246-7300
Check the appropriate box below if the Form 8-K filing is intended to simultaneously satisfy the filing obligations of the registrant under any of the following provisions:
¨
Written communications pursuant to Rule 425 under the Securities Act (17 CFR 230.425)
¨
Soliciting material pursuant to Rule 14a-12 under the Exchange Act (17 CFR 240.14a-12)
¨
Pre-commencement communications pursuant to Rule 14d-2(b) under the Exchange Act (17 CFR 240.14d-2(b))
¨
Pre-commencement communications pursuant to Rule 13e-4(c) under the Exchange Act (17 CFR 240.13e-4(c))
Item 1.01 Entry into a Material Definitive Agreement.
On March 14, 2014 Portola Pharmaceuticals, Inc. (the "Company") entered into that certain Second Amendment to Lease (the "Amended Lease"), by and between the Company and Britannia Pointe Grand Limited Partnership (the "Landlord").  The Amended Lease amended the terms of that certain Lease dated December 15, 2006 by and between the Company and the Landlord, as amended by that certain First Amendment to Lease dated May 21, 2010.
The Amended Lease extends the term of the Company's existing lease for its corporate headquarters from March 2015 to March 2020, with an early termination option by the Company in March 2018.  The Amended Lease also increases the total amount of space leased by the Company by approximately 20 percent.  The Amended Lease increases the Company's monthly rent from approximately $140,000 per month to approximately $169,000 per month.  The Amended Lease also includes a tenant improvement allowance paid by the Landlord of approximately $1.84 million.
A copy of the Amended Lease is attached as Exhibit 10.22 and incorporated by reference herein.
Item 9.01 Financial Statements and Exhibits
(d) Exhibits
10.22
Second Amendment to Lease made and entered into as of the 14
th
day of March 2014, by and between Portola Pharmaceuticals, Inc. and Britannia Pointe Grand Limited Partnership.
SIGNATURES
Pursuant to the requirements of the Securities Exchange Act of 1934, the Registrant has duly caused this report to be signed on its behalf by the undersigned hereunto duly authorized.
Portola Pharmaceuticals, Inc.
Dated: March 19, 2014
By:
/s/ Mardi C. Dier
Mardi C. Dier
Executive Vice President and Chief Financial Officer
EXHIBIT INDEX
Number
Description of Document
10.22
Second Amendment to Lease made and entered into as of the 14th day of March 2014, by and between Portola Pharmaceuticals, Inc. and Britannia Pointe Grand Limited Partnership.