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  <TITLE> AVALON PHARMACEUTICALS, INC. (Form: 8-K) </TITLE>
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  		UNITED STATES<BR>
  	SECURITIES AND EXCHANGE COMMISSION
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  	WASHINGTON, D.C. 20549
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  	FORM 8-K
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  	CURRENT REPORT
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  	Pursuant to Section&nbsp;13 or 15(d) of the Securities Exchange Act of 1934
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  	Date of Report (Date of Earliest Event Reported):
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  	&nbsp;
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  	March 5, 2007
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  	AVALON PHARMACEUTICALS, INC.
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  <BR>__________________________________________<BR>
  	(Exact name of registrant as specified in its charter)
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  	Delaware
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  	001-32629
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  	52-2209310
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  _____________________<BR>
  	(State or other jurisdiction
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  _____________<BR>
  	(Commission
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  ______________<BR>
  	(I.R.S. Employer
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  	of incorporation)
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  	File Number)
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  	Identification No.)
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  	&nbsp;&nbsp;
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  	&nbsp;
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  	20358 Seneca Meadows Parkway, Germantown, Maryland
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  	20876
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  _________________________________<BR>
  	(Address of principal executive offices)
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  	&nbsp;
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  ___________<BR>
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  	Registrant&#146;s telephone number, including area code:
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  	301-556-9900
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  	Not Applicable
  <BR>______________________________________________<BR>
  	Former name or former address, if changed since last report
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  <FONT SIZE="2">
  	&nbsp;
  </FONT>
  <!-- CoverPageRegistrant END --><P><FONT SIZE="2">
  Check the appropriate box below if the Form 8-K filing is intended to
  simultaneously satisfy the filing obligation of the registrant under any
  of the following provisions:</FONT>
  </P>
  <P><FONT SIZE="2">
  [&nbsp;&nbsp;]&nbsp;&nbsp;Written communications pursuant to Rule 425 under the Securities Act (17 CFR 230.425)<br>
  [&nbsp;&nbsp;]&nbsp;&nbsp;Soliciting material pursuant to Rule 14a-12 under the Exchange Act (17 CFR 240.14a-12)<br>
  [&nbsp;&nbsp;]&nbsp;&nbsp;Pre-commencement communications pursuant to Rule 14d-2(b) under the Exchange Act (17 CFR 240.14d-2(b))<br>
  [&nbsp;&nbsp;]&nbsp;&nbsp;Pre-commencement communications pursuant to Rule 13e-4(c) under the Exchange Act (17 CFR 240.13e-4(c))<br>
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  <B>
  	Item 1.01 Entry into a Material Definitive Agreement.
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  On March 5, 2007, Avalon Pharmaceuticals, Inc. ("Avalon") entered into an Exclusive License and Research Collaboration Agreement (the "Agreement") with Merck & Co., Inc. ("Merck") for the discovery and possible development of selective small molecule inhibitors for a target important in the development of cancer.   Under the terms of the Agreement, Avalon will be using AvalonRx&#174; to identify lead compounds and Merck is responsible for clinical development, regulatory approval and commercialization of any potential product candidates.  Pursuant to the Agreement, both parties have agreed to work exclusively with one another during the term of the research program in developing compounds for the inhibition of the selected target, in the case of Merck subject to certain milestones being met during the research program.  A copy of the press release announcing the Agreement is attached hereto as Exhibit 99.1 and incorporated herein by reference.<br><br>Under the Agreement, Avalon will receive payments from Merck upon Merck's initial designation of a lead compound as an exclusively licensed compound and and will receive additional milestone payments based on meeting a number of development and commercial milestones relating to proof of concept, filing of INDs for a first cancer indication and subsequent cancer indications, initiations of different levels of clinical trials for those indications and the filing, and approval, of NDAs for those indications, and achievement of a specified significant level of net sales.  If Avalon achieves all of the milestones under the Agreement, Avalon will receive approximately $200 million in milestone payments.  Avalon will also receive royalties on net sales of products developed in the collaboration.  The Agreement does not provide for any minimum guaranteed or upfront payments to Avalon by Merck.<br><br>The term of the Agreement expires upon the expiration of all royalty obligations under the Agreement.  The Agreement may be terminated earlier by Merck upon 60 days advanced written notice during the preliminary stages of the research program and thereafter during the research program if certain levels of research support are not provided by Avalon or certain research milestones are not met, in certain circumstances subject in the latter case to the payment of specified fees by Merck to Avalon and the right of Avalon to obtain certain licenses from Merck to continue the development and commercialization of potential product candidates derived from the research program.  The Agreement may be further terminated by Avalon upon 30 days advanced written notice to Merck if Merck determines that development of a compound is not commercially viable.  Additionally, the Agreement may be terminated either by Avalon or by Merck upon a material, uncured breach by the other party of the terms of the Agreement, following the expiration of a 90 day cure period.<br>
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  <B>
  	Item 9.01 Financial Statements and Exhibits.
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  (d) Exhibits<br><br>99.1 - Press Release dated March 6, 2007
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  	SIGNATURES
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  	Pursuant to the requirements of the Securities Exchange Act of 1934, the
  	registrant has duly caused this report to be signed on its behalf by the
  	undersigned hereunto duly authorized.
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  	AVALON PHARMACEUTICALS, INC.
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  	&nbsp;&nbsp;
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  <I>
  	March 8, 2007
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  	By:
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  <I>
  	/s/ Thomas  G. David, Esq.
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  <I>
  	Name: Thomas  G. David, Esq.
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  <I>
  	Title: General Counsel
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  	Exhibit&nbsp;Index
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  	Exhibit No.
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  	Description
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  	99.1
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  	&nbsp;
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  <FONT SIZE="2">
  Press Release dated March 6, 2007
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metadata_documents: [{"type": "8-K", "sequence": "1", "filename": "htm_18777.htm", "description": "LIVE FILING", "secsgml_size_bytes": 12652}]
metadata_filer: {"company-data": {"conformed-name": "AVALON PHARMACEUTICALS INC", "cik": "0001162192", "assigned-sic": "2834", "irs-number": "522209310"}, "filing-values": {"form-type": "8-K", "act": "34", "file-number": "001-32629", "film-number": "07680997"}, "business-address": {"street1": "20358 SENECA MEADOWS PARKWAY", "city": "GERMANTOWN", "state": "MD", "zip": "20876", "phone": "3015569900"}, "mail-address": {"street1": "20358 SENECA MEADOWS PARKWAY", "city": "GERMANTOWN", "state": "MD", "zip": "20876"}}
text: AVALON PHARMACEUTICALS, INC. (Form: 8-K)
  UNITED STATES
  SECURITIES AND EXCHANGE COMMISSION
  WASHINGTON, D.C. 20549
  FORM 8-K
  CURRENT REPORT
  Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934
  Date of Report (Date of Earliest Event Reported):
  March 5, 2007
  AVALON PHARMACEUTICALS, INC.
  __________________________________________
  (Exact name of registrant as specified in its charter)
  Delaware
  001-32629
  52-2209310
  _____________________
  (State or other jurisdiction
  _____________
  (Commission
  ______________
  (I.R.S. Employer
  of incorporation)
  File Number)
  Identification No.)
  20358 Seneca Meadows Parkway, Germantown, Maryland
  20876
  _________________________________
  (Address of principal executive offices)
  ___________
  (Zip Code)
  Registrant's telephone number, including area code:
  301-556-9900
  Not Applicable
  ______________________________________________
  Former name or former address, if changed since last report
  Check the appropriate box below if the Form 8-K filing is intended to
  simultaneously satisfy the filing obligation of the registrant under any
  of the following provisions:
  [  ]  Written communications pursuant to Rule 425 under the Securities Act (17 CFR 230.425)
  [  ]  Soliciting material pursuant to Rule 14a-12 under the Exchange Act (17 CFR 240.14a-12)
  [  ]  Pre-commencement communications pursuant to Rule 14d-2(b) under the Exchange Act (17 CFR 240.14d-2(b))
  [  ]  Pre-commencement communications pursuant to Rule 13e-4(c) under the Exchange Act (17 CFR 240.13e-4(c))
  Top of the Form
  Item 1.01 Entry into a Material Definitive Agreement.
  On March 5, 2007, Avalon Pharmaceuticals, Inc. ("Avalon") entered into an Exclusive License and Research Collaboration Agreement (the "Agreement") with Merck & Co., Inc. ("Merck") for the discovery and possible development of selective small molecule inhibitors for a target important in the development of cancer.   Under the terms of the Agreement, Avalon will be using AvalonRx® to identify lead compounds and Merck is responsible for clinical development, regulatory approval and commercialization of any potential product candidates.  Pursuant to the Agreement, both parties have agreed to work exclusively with one another during the term of the research program in developing compounds for the inhibition of the selected target, in the case of Merck subject to certain milestones being met during the research program.  A copy of the press release announcing the Agreement is attached hereto as Exhibit 99.1 and incorporated herein by reference.
  Under the Agreement, Avalon will receive payments from Merck upon Merck's initial designation of a lead compound as an exclusively licensed compound and and will receive additional milestone payments based on meeting a number of development and commercial milestones relating to proof of concept, filing of INDs for a first cancer indication and subsequent cancer indications, initiations of different levels of clinical trials for those indications and the filing, and approval, of NDAs for those indications, and achievement of a specified significant level of net sales.  If Avalon achieves all of the milestones under the Agreement, Avalon will receive approximately $200 million in milestone payments.  Avalon will also receive royalties on net sales of products developed in the collaboration.  The Agreement does not provide for any minimum guaranteed or upfront payments to Avalon by Merck.
  The term of the Agreement expires upon the expiration of all royalty obligations under the Agreement.  The Agreement may be terminated earlier by Merck upon 60 days advanced written notice during the preliminary stages of the research program and thereafter during the research program if certain levels of research support are not provided by Avalon or certain research milestones are not met, in certain circumstances subject in the latter case to the payment of specified fees by Merck to Avalon and the right of Avalon to obtain certain licenses from Merck to continue the development and commercialization of potential product candidates derived from the research program.  The Agreement may be further terminated by Avalon upon 30 days advanced written notice to Merck if Merck determines that development of a compound is not commercially viable.  Additionally, the Agreement may be terminated either by Avalon or by Merck upon a material, uncured breach by the other party of the terms of the Agreement, following the expiration of a 90 day cure period.
  Item 9.01 Financial Statements and Exhibits.
  (d) Exhibits
  99.1 - Press Release dated March 6, 2007
  Top of the Form
  SIGNATURES
  Pursuant to the requirements of the Securities Exchange Act of 1934, the
  	registrant has duly caused this report to be signed on its behalf by the
  	undersigned hereunto duly authorized.
  AVALON PHARMACEUTICALS, INC.
  March 8, 2007
  By:
  /s/ Thomas  G. David, Esq.
  Name: Thomas  G. David, Esq.
  Title: General Counsel
  Top of the Form
  Exhibit Index
  Exhibit No.
  Description
  99.1
  Press Release dated March 6, 2007