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  <p align="center" style="margin:0in 0in .0001pt;text-align:center;"><b><font size="5" face="Times New Roman" style="font-size:18.0pt;font-weight:bold;">UNITED STATES</font></b></p>
  
  <p align="center" style="margin:0in 0in .0001pt;text-align:center;"><b><font size="5" face="Times New Roman" style="font-size:18.0pt;font-weight:bold;">SECURITIES AND EXCHANGE COMMISSION</font></b></p>
  
  <p align="center" style="margin:0in 0in .0001pt;text-align:center;"><b><font size="2" face="Times New Roman" style="font-size:10.0pt;font-weight:bold;">Washington,
  DC 20549</font></b></p>
  
  <p align="center" style="margin:0in 0in .0001pt;text-align:center;"><font size="2" face="Times New Roman">&nbsp;</font></p>
  
  <div align="center" style="margin:0in 0in .0001pt;text-align:center;"><hr size="1" width="25%" noshade color="black" align="center"></div>
  
  <p align="center" style="margin:0in 0in .0001pt;text-align:center;"><font size="2" face="Times New Roman">&nbsp;</font></p>
  
  <p align="center" style="margin:0in 0in .0001pt;text-align:center;"><b><font size="5" face="Times New Roman" style="font-size:18.0pt;font-weight:bold;">FORM&nbsp;8-K</font></b></p>
  
  <p align="center" style="margin:0in 0in .0001pt;text-align:center;"><font size="2" face="Times New Roman">&nbsp;</font></p>
  
  <p align="center" style="margin:0in 0in .0001pt;text-align:center;"><b><font size="3" face="Times New Roman" style="font-size:12.0pt;font-weight:bold;">CURRENT REPORT</font></b></p>
  
  <p align="center" style="margin:0in 0in .0001pt;text-align:center;"><b><font size="3" face="Times New Roman" style="font-size:12.0pt;font-weight:bold;">Pursuant to Section&nbsp;13 or 15(d)&nbsp;of
  the<br>
  Securities Exchange Act of 1934</font></b></p>
  
  <p align="center" style="margin:0in 0in .0001pt;text-align:center;"><font size="2" face="Times New Roman">&nbsp;</font></p>
  
  <p align="center" style="font-size:10.0pt;margin:0in 0in .0001pt;text-align:center;"><b><font size="2" face="Times New Roman" style="font-size:10.0pt;font-weight:bold;">Date of
  Report (Date of earliest event reported):</font></b>  <b>May&nbsp;27, 2008</b></p>
  
  <p align="center" style="margin:0in 0in .0001pt;text-align:center;"><font size="2" face="Times New Roman">&nbsp;</font></p>
  
  <p align="center" style="margin:0in 0in .0001pt;text-align:center;"><b><font size="5" face="Times New Roman" style="font-size:18.0pt;font-weight:bold;">AFFYMAX,
  INC.</font></b></p>
  
  <p align="center" style="margin:0in 0in .0001pt;text-align:center;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">(Exact name of
  registrant as specified in charter)</font></p>
  
  <p align="center" style="margin:0in 0in .0001pt;text-align:center;"><font size="2" face="Times New Roman">&nbsp;</font></p>
  
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    <p align="center" style="margin:0in 0in .0001pt;text-align:center;"><b><font size="2" face="Times New Roman" style="font-size:10.0pt;font-weight:bold;">Delaware</font></b></p>
    </td>
    <td width="2%" valign="bottom" style="padding:0in 0in 0in 0in;width:2.0%;">
    <p style="margin:0in 0in .0001pt;"><b><font size="2" face="Times New Roman" style="font-size:1.0pt;font-weight:bold;">&nbsp;</font></b></p>
    </td>
    <td width="32%" valign="top" style="padding:0in 0in 0in 0in;width:32.0%;">
    <p align="center" style="margin:0in 0in .0001pt;text-align:center;"><b><font size="2" face="Times New Roman" style="font-size:10.0pt;font-weight:bold;">001-33213</font></b></p>
    </td>
    <td width="2%" valign="bottom" style="padding:0in 0in 0in 0in;width:2.0%;">
    <p style="margin:0in 0in .0001pt;"><b><font size="2" face="Times New Roman" style="font-size:1.0pt;font-weight:bold;">&nbsp;</font></b></p>
    </td>
    <td width="32%" valign="top" style="padding:0in 0in 0in 0in;width:32.0%;">
    <p align="center" style="margin:0in 0in .0001pt;text-align:center;"><b><font size="2" face="Times New Roman" style="font-size:10.0pt;font-weight:bold;">77-0579396</font></b></p>
    </td>
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    <td width="32%" valign="top" style="padding:0in 0in 0in 0in;width:32.0%;">
    <p align="center" style="margin:0in 0in .0001pt;text-align:center;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">(State or other jurisdiction of</font></p>
    </td>
    <td width="2%" valign="bottom" style="padding:0in 0in 0in 0in;width:2.0%;">
    <p style="margin:0in 0in .0001pt;"><font size="2" face="Times New Roman" style="font-size:1.0pt;">&nbsp;</font></p>
    </td>
    <td width="32%" valign="top" style="padding:0in 0in 0in 0in;width:32.0%;">
    <p align="center" style="margin:0in 0in .0001pt;text-align:center;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">(Commission File Number)</font></p>
    </td>
    <td width="2%" valign="bottom" style="padding:0in 0in 0in 0in;width:2.0%;">
    <p style="margin:0in 0in .0001pt;"><font size="2" face="Times New Roman" style="font-size:1.0pt;">&nbsp;</font></p>
    </td>
    <td width="32%" valign="top" style="padding:0in 0in 0in 0in;width:32.0%;">
    <p align="center" style="margin:0in 0in .0001pt;text-align:center;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">(I.R.S. Employer Identification No.)</font></p>
    </td>
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   <tr>
    <td width="32%" valign="top" style="padding:0in 0in 0in 0in;width:32.0%;">
    <p align="center" style="margin:0in 0in .0001pt;text-align:center;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">incorporation)</font></p>
    </td>
    <td width="2%" valign="bottom" style="padding:0in 0in 0in 0in;width:2.0%;">
    <p style="margin:0in 0in .0001pt;"><font size="2" face="Times New Roman" style="font-size:1.0pt;">&nbsp;</font></p>
    </td>
    <td width="32%" valign="top" style="padding:0in 0in 0in 0in;width:32.0%;">
    <p align="center" style="margin:0in 0in .0001pt;text-align:center;"><font size="2" face="Times New Roman" style="font-size:1.0pt;">&nbsp;</font></p>
    </td>
    <td width="2%" valign="bottom" style="padding:0in 0in 0in 0in;width:2.0%;">
    <p style="margin:0in 0in .0001pt;"><font size="2" face="Times New Roman" style="font-size:1.0pt;">&nbsp;</font></p>
    </td>
    <td width="32%" valign="top" style="padding:0in 0in 0in 0in;width:32.0%;">
    <p align="center" style="margin:0in 0in .0001pt;text-align:center;"><font size="2" face="Times New Roman" style="font-size:1.0pt;">&nbsp;</font></p>
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  <p align="center" style="margin:0in 0in .0001pt;text-align:center;"><font size="2" face="Times New Roman">&nbsp;</font></p>
  
  <p align="center" style="margin:0in 0in .0001pt;text-align:center;"><b><font size="2" face="Times New Roman" style="font-size:10.0pt;font-weight:bold;">4001 Miranda Avenue</font></b></p>
  
  <p align="center" style="margin:0in 0in .0001pt;text-align:center;"><b><font size="2" face="Times New Roman" style="font-size:10.0pt;font-weight:bold;">Palo Alto, California 94304</font></b></p>
  
  <p align="center" style="margin:0in 0in .0001pt;text-align:center;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">(Address of
  principal executive offices and zip code)</font></p>
  
  <p align="center" style="margin:0in 0in .0001pt;text-align:center;"><font size="2" face="Times New Roman">&nbsp;</font></p>
  
  <p align="center" style="margin:0in 0in .0001pt;text-align:center;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">Registrant&#146;s
  telephone number, including area code:<b> (650)
  812 -8700</b></font></p>
  
  <p align="center" style="margin:0in 0in .0001pt;text-align:center;"><font size="2" face="Times New Roman">&nbsp;</font></p>
  
  <div align="center" style="margin:0in 0in .0001pt;text-align:center;"><hr size="1" width="25%" noshade color="black" align="center"></div>
  
  <p align="center" style="margin:0in 0in .0001pt;text-align:center;"><font size="2" face="Times New Roman">&nbsp;</font></p>
  
  <p style="margin:0in 0in .0001pt;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">Check
  the appropriate box below if the Form&nbsp;8-K filing is intended to
  simultaneously satisfy the filing obligation of the registrant under any of the
  following provisions:</font></p>
  
  <p style="margin:0in 0in .0001pt;"><font size="2" face="Times New Roman">&nbsp;</font></p>
  
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    <p style="margin:0in 0in .0001pt;"><font size="2" face="Wingdings" style="font-size:10.0pt;">o</font></p>
    </td>
    <td width="97%" valign="top" style="padding:0in 0in 0in 0in;width:97.34%;">
    <p style="margin:0in 0in .0001pt;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">Written
    communications pursuant to Rule&nbsp;425 under the Securities Act (17 CFR
    230.425)</font></p>
    </td>
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    <td width="2%" valign="top" style="padding:0in 0in 0in 0in;width:2.66%;">
    <p style="margin:0in 0in .0001pt;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>
    </td>
    <td width="97%" valign="top" style="padding:0in 0in 0in 0in;width:97.34%;">
    <p style="margin:0in 0in .0001pt;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>
    </td>
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    <p style="margin:0in 0in .0001pt;"><font size="2" face="Wingdings" style="font-size:10.0pt;">o</font></p>
    </td>
    <td width="97%" valign="top" style="padding:0in 0in 0in 0in;width:97.34%;">
    <p style="margin:0in 0in .0001pt;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">Soliciting
    material pursuant to Rule&nbsp;14a-12(b)&nbsp;under the Exchange Act (17 CFR
    240.14a-12(b))</font></p>
    </td>
   </tr>
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    <td width="2%" valign="top" style="padding:0in 0in 0in 0in;width:2.66%;">
    <p style="margin:0in 0in .0001pt;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>
    </td>
    <td width="97%" valign="top" style="padding:0in 0in 0in 0in;width:97.34%;">
    <p style="margin:0in 0in .0001pt;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>
    </td>
   </tr>
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    <td width="2%" valign="top" style="padding:0in 0in 0in 0in;width:2.66%;">
    <p style="margin:0in 0in .0001pt;"><font size="2" face="Wingdings" style="font-size:10.0pt;">o</font></p>
    </td>
    <td width="97%" valign="top" style="padding:0in 0in 0in 0in;width:97.34%;">
    <p style="margin:0in 0in .0001pt;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">Pre-commencement
    communications pursuant to Rule&nbsp;14d-2(b)&nbsp;under the Exchange Act (17
    CFR 240.14d-2(b))</font></p>
    </td>
   </tr>
   <tr>
    <td width="2%" valign="top" style="padding:0in 0in 0in 0in;width:2.66%;">
    <p style="margin:0in 0in .0001pt;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>
    </td>
    <td width="97%" valign="top" style="padding:0in 0in 0in 0in;width:97.34%;">
    <p style="margin:0in 0in .0001pt;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>
    </td>
   </tr>
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    <td width="2%" valign="top" style="padding:0in 0in 0in 0in;width:2.66%;">
    <p style="margin:0in 0in .0001pt;"><font size="2" face="Wingdings" style="font-size:10.0pt;">o</font></p>
    </td>
    <td width="97%" valign="top" style="padding:0in 0in 0in 0in;width:97.34%;">
    <p style="margin:0in 0in .0001pt;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">Pre-commencement
    communications pursuant to Rule&nbsp;13e-4(c)&nbsp;under the Exchange Act (17
    CFR 240.13e-4(c))</font></p>
    </td>
   </tr>
  </table>
  
  <div style="border:none;border-bottom:double windowtext 6.0pt;padding:0in 0in 0in 0in;">
  
  <p style="border:none;margin:0in 0in .0001pt;padding:0in;"><font size="2" face="Times New Roman">&nbsp;</font></p>
  
  </div>
  
  <p style="margin:0in 0in .0001pt;"><font size="2" face="Times New Roman">&nbsp;</font></p>
  
  <div style="margin:0in 0in .0001pt;"><hr size="3" width="100%" noshade color="#010101" align="left"></div>
  
  </div>
  <!-- SEQ.=1,FOLIO='',FILE='C:\JMS\C900110\08-15627-1\task2968057\15627-1-ba.htm',USER='C900110',CD='May 31 00:41 2008' -->
  
  
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  <p align="center" style="margin:0in 0in .0001pt;text-align:center;"><font size="2" face="Times New Roman">&nbsp;</font></p>
  
  <p style="font-size:10.0pt;margin:0in 0in .0001pt;"><b><font size="2" face="Times New Roman" style="font-size:10.0pt;font-weight:bold;">Item</font></b>&nbsp;
  <b>4.01. Changes in
  Registrant&#146;s Certifying Accountant.</b></p>
  
  <p style="margin:0in 0in .0001pt;"><font size="2" face="Times New Roman">&nbsp;</font></p>
  
  <p style="margin:0in 0in .0001pt;text-indent:46.95pt;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">(a)&nbsp;<u>Dismissal of PricewaterhouseCoopers LLP</u>.
  On May&nbsp;27, 2008, Affymax,&nbsp;Inc. (the &#147;Registrant&#148;) notified
  PricewaterhouseCoopers LLP (&#147;PwC&#148;) that the Registrant was dismissing PwC as
  its independent registered public accounting firm, effective immediately. The
  Registrant&#146;s Audit Committee of the Board of Directors approved the dismissal
  of PwC as the Registrant&#146;s independent registered public accounting firm.</font></p>
  
  <p style="margin:0in 0in .0001pt;text-indent:46.95pt;"><font size="2" face="Times New Roman">&nbsp;</font></p>
  
  <p style="margin:0in 0in .0001pt;text-indent:.65in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">The PwC report
  on the Registrant&#146;s financial statements for the fiscal years ended December&nbsp;31,
  2007 and 2006 did not contain an adverse opinion or a disclaimer of opinion,
  nor was such report qualified or modified as to uncertainty, audit scope or
  accounting principle.</font></p>
  
  <p style="margin:0in 0in .0001pt;text-indent:44.85pt;"><font size="2" face="Times New Roman">&nbsp;</font></p>
  
  <p style="margin:0in 0in .0001pt;text-indent:44.85pt;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">During the fiscal years ended December&nbsp;31, 2007
  and 2006 and through May&nbsp;27, 2008, there were no disagreements with PwC on
  any matter of accounting principles or practices, financial statement
  disclosure, or auditing scope or procedure, which disagreements, if not
  resolved to the satisfaction of PwC, would have caused PwC to make reference to
  the subject matter of the disagreements in its reports on the Registrant&#146;s
  financial statements for such years.</font></p>
  
  <p style="margin:0in 0in .0001pt;text-indent:44.85pt;"><font size="2" face="Times New Roman">&nbsp;</font></p>
  
  <p style="font-size:10.0pt;margin:0in 0in .0001pt;text-indent:44.85pt;"><font size="2" face="Times New Roman"><font style="font-size:10.0pt;">As previously disclosed in the Item 4 section of the
  Registrant&#146;s Form&nbsp;10-Q for the quarter ended</font>  </font>September&nbsp;30, 2007, two material
  weaknesses in internal controls over financial reporting existed.&#160; One material weakness was due to ineffective
  controls over the completeness and accuracy of deferred income tax assets and
  liabilities and the income tax provision.&#160;
  The other material weakness was due to ineffective controls over the accuracy
  of collaboration revenue.&#160; Management of
  the Registrant believes that both such material weaknesses were remediated as
  of December&nbsp;31, 2007.&#160; Except for
  the two material weaknesses discussed above, during the fiscal years ended December&nbsp;31,
  2007 and 2006 and through May&nbsp;27, 2008, there were no reportable events
  pursuant to Item 304(a)(1)(v)&nbsp;of Regulation S-K.&#160; Management of the Registrant has authorized
  PwC to respond fully to the inquiries of the new independent registered public
  accounting firm regarding all matters.</p>
  
  <p style="margin:0in 0in .0001pt;text-indent:44.85pt;"><font size="2" face="Times New Roman">&nbsp;</font></p>
  
  <p style="margin:0in 0in .0001pt;text-indent:.5in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">The Registrant has
  provided PwC with a copy of the above disclosures and requested that PwC
  furnish the Registrant with a letter addressed to the Securities and Exchange
  Commission stating whether it agrees with the foregoing statements and, if not,
  stating the respects in which it does not agree. A copy of the letter from PwC
  is filed herewith as Exhibit&nbsp;16.1.</font></p>
  
  <p style="margin:0in 0in .0001pt;text-indent:.5in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>
  
  <p style="margin:0in 0in .0001pt;text-indent:46.95pt;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">(b)&nbsp;<u>Engagement of Ernst&nbsp;&amp; Young LLP</u>.
  On May&nbsp;27, 2008, the Audit Committee of the Board of Directors of
  Registrant engaged Ernst&nbsp;&amp; Young LLP (&#147;E&amp;Y&#148;) to serve as the
  Registrant&#146;s independent registered public accounting firm. During the fiscal
  years ended December&nbsp;31, 2007 and 2006 and through May&nbsp;27, 2008, the
  Registrant did not consult E&amp;Y with respect to any of the matters or events
  listed in Regulation S-K Item&nbsp;304(a)(2)(i)&nbsp;and (ii).</font></p>
  
  <p style="margin:0in 0in .0001pt;"><font size="2" face="Times New Roman">&nbsp;</font></p>
  
  <p style="margin:0in 0in .0001pt;"><b><font size="2" face="Times New Roman" style="font-size:10.0pt;font-weight:bold;">Item 9.01. Financial Statements and Exhibits.</font></b></p>
  
  <p style="margin:0in 0in .0001pt;"><font size="2" face="Times New Roman">&nbsp;</font></p>
  
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    <td width="6%" valign="top" style="padding:0in 0in 0in 0in;width:6.92%;">
    <p style="margin:0in 0in .0001pt;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">(d)</font></p>
    </td>
    <td width="1%" valign="bottom" style="padding:0in 0in 0in 0in;width:1.58%;">
    <p style="margin:0in 0in .0001pt;"><font size="2" face="Times New Roman" style="font-size:1.0pt;">&nbsp;</font></p>
    </td>
    <td width="91%" valign="top" style="padding:0in 0in 0in 0in;width:91.5%;">
    <p style="font-size:10.0pt;margin:0in 0in .0001pt;"><u><font size="2" face="Times New Roman" style="font-size:10.0pt;">Exhibits</font></u>.</p>
    </td>
   </tr>
  </table>
  
  <p style="margin:0in 0in .0001pt;"><font size="2" face="Times New Roman">&nbsp;</font></p>
  
  <table border="0" cellspacing="0" cellpadding="0" width="100%" style="border-collapse:collapse;width:100.0%;">
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    <td width="7%" valign="top" style="border:none;border-bottom:solid windowtext 1.0pt;padding:0in 0in 0in 0in;width:7.66%;">
    <p style="margin:0in 0in .0001pt;"><b><font size="1" face="Times New Roman" style="font-size:8.0pt;font-weight:bold;">Exhibits</font></b></p>
    </td>
    <td width="2%" valign="bottom" style="padding:0in 0in 0in 0in;width:2.5%;">
    <p style="margin:0in 0in .0001pt;"><b><font size="1" face="Times New Roman" style="font-size:1.0pt;font-weight:bold;">&nbsp;</font></b></p>
    </td>
    <td width="89%" valign="top" style="border:none;border-bottom:solid windowtext 1.0pt;padding:0in 0in 0in 0in;width:89.84%;">
    <p align="center" style="margin:0in 0in .0001pt;text-align:center;"><b><font size="1" face="Times New Roman" style="font-size:8.0pt;font-weight:bold;">Descriptions</font></b></p>
    </td>
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    <td width="7%" valign="top" style="border:none;padding:0in 0in 0in 0in;width:7.66%;">
    <p style="margin:0in 0in .0001pt;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>
    </td>
    <td width="2%" valign="bottom" style="padding:0in 0in 0in 0in;width:2.5%;">
    <p style="margin:0in 0in .0001pt;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>
    </td>
    <td width="89%" valign="top" style="border:none;padding:0in 0in 0in 0in;width:89.84%;">
    <p style="margin:0in 0in .0001pt;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>
    </td>
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    <td width="7%" valign="top" style="padding:0in 0in 0in 0in;width:7.66%;">
    <p style="margin:0in 0in .0001pt;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">16.1</font></p>
    </td>
    <td width="2%" valign="bottom" style="padding:0in 0in 0in 0in;width:2.5%;">
    <p style="margin:0in 0in .0001pt;"><font size="2" face="Times New Roman" style="font-size:1.0pt;">&nbsp;</font></p>
    </td>
    <td width="89%" valign="top" style="padding:0in 0in 0in 0in;width:89.84%;">
    <p style="margin:0in 0in .0001pt;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">Letter
    from PricewaterhouseCoopers LLP dated May&nbsp;30, 2008.</font></p>
    </td>
   </tr>
  </table>
  
  <p align="center" style="margin:0in 0in .0001pt;text-align:center;"><font size="2" face="Times New Roman">&nbsp;</font></p>
  
  <p align="center" style="margin:0in 0in .0001pt;text-align:center;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">2</font></p>
  
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  <!-- SEQ.=1,FOLIO='2',FILE='C:\JMS\C900110\08-15627-1\task2968057\15627-1-ba.htm',USER='C900110',CD='May 31 00:41 2008' -->
  
  
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  <div style="font-family:Times New Roman;">
  
  <p style="margin:0in 0in .0001pt;"><font size="2" face="Times New Roman">&nbsp;</font></p>
  
  <p align="center" style="margin:0in 0in .0001pt;text-align:center;"><b><font size="2" face="Times New Roman" style="font-size:10.0pt;font-weight:bold;">SIGNATURES</font></b></p>
  
  <p align="center" style="margin:0in 0in .0001pt;text-align:center;"><b><font size="2" face="Times New Roman">&nbsp;</font></b></p>
  
  <p style="margin:0in 0in .0001pt;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Pursuant to the requirements of
  the Securities Exchange Act of 1934, the Registrant has duly caused this report
  to be signed on its behalf by the undersigned, hereunto duly authorized.</font></p>
  
  <p style="margin:0in 0in .0001pt;"><font size="2" face="Times New Roman">&nbsp;</font></p>
  
  <table border="0" cellspacing="0" cellpadding="0" width="100%" style="border-collapse:collapse;width:100.0%;">
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    <td width="52%" valign="top" style="padding:0in 0in 0in 0in;width:52.92%;">
    <p style="margin:0in 0in .0001pt;"><font size="2" face="Times New Roman" style="font-size:1.0pt;">&nbsp;</font></p>
    </td>
    <td width="47%" colspan="2" valign="top" style="padding:0in 0in 0in 0in;width:47.08%;">
    <p style="font-size:10.0pt;margin:0in 0in .0001pt;"><b><font size="2" face="Times New Roman" style="font-size:10.0pt;font-weight:bold;">AFFYMAX, I</font></b><b>NC </b><b>.</b></p>
    </td>
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    <td width="52%" valign="top" style="padding:0in 0in 0in 0in;width:52.92%;">
    <p style="margin:0in 0in .0001pt;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>
    </td>
    <td width="3%" valign="top" style="padding:0in 0in 0in 0in;width:3.76%;">
    <p style="margin:0in 0in .0001pt;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>
    </td>
    <td width="43%" valign="top" style="padding:0in 0in 0in 0in;width:43.32%;">
    <p style="margin:0in 0in .0001pt;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>
    </td>
   </tr>
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    <td width="52%" valign="top" style="padding:0in 0in 0in 0in;width:52.92%;">
    <p style="margin:0in 0in .0001pt;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">Dated:
    May&nbsp;30, 2008</font></p>
    </td>
    <td width="3%" valign="top" style="padding:0in 0in 0in 0in;width:3.76%;">
    <p style="margin:0in 0in .0001pt;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">By:</font></p>
    </td>
    <td width="43%" valign="top" style="padding:0in 0in 0in 0in;width:43.32%;">
    <p style="margin:0in 0in .0001pt;"><font size="2" face="Times New Roman" style="font-size:1.0pt;">&nbsp;</font></p>
    </td>
   </tr>
   <tr>
    <td width="52%" valign="top" style="padding:0in 0in 0in 0in;width:52.92%;">
    <p style="margin:0in 0in .0001pt;"><b><font size="2" face="Times New Roman" style="font-size:1.0pt;font-weight:bold;">&nbsp;</font></b></p>
    </td>
    <td width="3%" valign="top" style="padding:0in 0in 0in 0in;width:3.76%;">
    <p style="margin:0in 0in .0001pt;"><b><font size="2" face="Times New Roman" style="font-size:1.0pt;font-weight:bold;">&nbsp;</font></b></p>
    </td>
    <td width="43%" valign="top" style="padding:0in 0in 0in 0in;width:43.32%;">
    <p align="center" style="margin:0in 0in .0001pt;text-align:center;"><b><font size="2" face="Times New Roman" style="font-size:10.0pt;font-weight:bold;">/s/ Paul B. Cleveland</font></b></p>
    </td>
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    <td width="52%" valign="top" style="padding:0in 0in 0in 0in;width:52.92%;">
    <p style="margin:0in 0in .0001pt;"><b><font size="2" face="Times New Roman" style="font-size:10.0pt;font-weight:bold;">&nbsp;</font></b></p>
    </td>
    <td width="3%" valign="top" style="padding:0in 0in 0in 0in;width:3.76%;">
    <p style="margin:0in 0in .0001pt;"><b><font size="2" face="Times New Roman" style="font-size:10.0pt;font-weight:bold;">&nbsp;</font></b></p>
    </td>
    <td width="43%" valign="top" style="border:none;border-bottom:solid windowtext 1.0pt;padding:0in 0in 0in 0in;width:43.32%;">
    <p style="margin:0in 0in .0001pt;"><b><font size="2" face="Times New Roman" style="font-size:10.0pt;font-weight:bold;">&nbsp;</font></b></p>
    </td>
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    <td width="52%" valign="top" style="padding:0in 0in 0in 0in;width:52.92%;">
    <p style="margin:0in 0in .0001pt;"><font size="2" face="Times New Roman" style="font-size:1.0pt;">&nbsp;</font></p>
    </td>
    <td width="3%" valign="top" style="padding:0in 0in 0in 0in;width:3.76%;">
    <p style="margin:0in 0in .0001pt;"><b><font size="2" face="Times New Roman" style="font-size:1.0pt;font-weight:bold;">&nbsp;</font></b></p>
    </td>
    <td width="43%" valign="top" style="border:none;padding:0in 0in 0in 0in;width:43.32%;">
    <p align="center" style="margin:0in 0in .0001pt;text-align:center;"><b><font size="2" face="Times New Roman" style="font-size:10.0pt;font-weight:bold;">Paul B.
    Cleveland<br>
    Executive Vice President, Corporate<br>
    Development and Chief Financial<br>
    Officer</font></b></p>
    </td>
   </tr>
  </table>
  
  <p align="center" style="margin:0in 0in .0001pt;text-align:center;"><font size="2" face="Times New Roman">&nbsp;</font></p>
  
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metadata_filer: {"company-data": {"conformed-name": "AFFYMAX INC", "cik": "0001158223", "assigned-sic": "2834", "irs-number": "000000000", "fiscal-year-end": "1231"}, "filing-values": {"form-type": "8-K", "act": "34", "file-number": "001-33213", "film-number": "08872569"}, "business-address": {"street1": "4001 MIRANDA AVE", "city": "PALO ALTO", "state": "CA", "zip": "94304"}}
text: UNITED STATES
  SECURITIES AND EXCHANGE COMMISSION
  Washington,
  DC 20549
  FORM 8-K
  CURRENT REPORT
  Pursuant to Section 13 or 15(d) of
  the
  Securities Exchange Act of 1934
  Date of
  Report (Date of earliest event reported):
  May 27, 2008
  AFFYMAX,
  INC.
  (Exact name of
  registrant as specified in charter)
  Delaware
  001-33213
  77-0579396
  (State or other jurisdiction of
  (Commission File Number)
  (I.R.S. Employer Identification No.)
  incorporation)
  4001 Miranda Avenue
  Palo Alto, California 94304
  (Address of
  principal executive offices and zip code)
  Registrant's
  telephone number, including area code:
  (650)
  812 -8700
  Check
  the appropriate box below if the Form 8-K filing is intended to
  simultaneously satisfy the filing obligation of the registrant under any of the
  following provisions:
  o
  Written
    communications pursuant to Rule 425 under the Securities Act (17 CFR
    230.425)
  o
  Soliciting
    material pursuant to Rule 14a-12(b) under the Exchange Act (17 CFR
    240.14a-12(b))
  o
  Pre-commencement
    communications pursuant to Rule 14d-2(b) under the Exchange Act (17
    CFR 240.14d-2(b))
  o
  Pre-commencement
    communications pursuant to Rule 13e-4(c) under the Exchange Act (17
    CFR 240.13e-4(c))
  Item
  4.01. Changes in
  Registrant's Certifying Accountant.
  (a)
  Dismissal of PricewaterhouseCoopers LLP
  .
  On May 27, 2008, Affymax, Inc. (the "Registrant") notified
  PricewaterhouseCoopers LLP ("PwC") that the Registrant was dismissing PwC as
  its independent registered public accounting firm, effective immediately. The
  Registrant's Audit Committee of the Board of Directors approved the dismissal
  of PwC as the Registrant's independent registered public accounting firm.
  The PwC report
  on the Registrant's financial statements for the fiscal years ended December 31,
  2007 and 2006 did not contain an adverse opinion or a disclaimer of opinion,
  nor was such report qualified or modified as to uncertainty, audit scope or
  accounting principle.
  During the fiscal years ended December 31, 2007
  and 2006 and through May 27, 2008, there were no disagreements with PwC on
  any matter of accounting principles or practices, financial statement
  disclosure, or auditing scope or procedure, which disagreements, if not
  resolved to the satisfaction of PwC, would have caused PwC to make reference to
  the subject matter of the disagreements in its reports on the Registrant's
  financial statements for such years.
  As previously disclosed in the Item 4 section of the
  Registrant's Form 10-Q for the quarter ended
  September 30, 2007, two material
  weaknesses in internal controls over financial reporting existed.  One material weakness was due to ineffective
  controls over the completeness and accuracy of deferred income tax assets and
  liabilities and the income tax provision. 
  The other material weakness was due to ineffective controls over the accuracy
  of collaboration revenue.  Management of
  the Registrant believes that both such material weaknesses were remediated as
  of December 31, 2007.  Except for
  the two material weaknesses discussed above, during the fiscal years ended December 31,
  2007 and 2006 and through May 27, 2008, there were no reportable events
  pursuant to Item 304(a)(1)(v) of Regulation S-K.  Management of the Registrant has authorized
  PwC to respond fully to the inquiries of the new independent registered public
  accounting firm regarding all matters.
  The Registrant has
  provided PwC with a copy of the above disclosures and requested that PwC
  furnish the Registrant with a letter addressed to the Securities and Exchange
  Commission stating whether it agrees with the foregoing statements and, if not,
  stating the respects in which it does not agree. A copy of the letter from PwC
  is filed herewith as Exhibit 16.1.
  (b)
  Engagement of Ernst & Young LLP
  .
  On May 27, 2008, the Audit Committee of the Board of Directors of
  Registrant engaged Ernst & Young LLP ("E&Y") to serve as the
  Registrant's independent registered public accounting firm. During the fiscal
  years ended December 31, 2007 and 2006 and through May 27, 2008, the
  Registrant did not consult E&Y with respect to any of the matters or events
  listed in Regulation S-K Item 304(a)(2)(i) and (ii).
  Item 9.01. Financial Statements and Exhibits.
  (d)
  Exhibits
  .
  Exhibits
  Descriptions
  16.1
  Letter
    from PricewaterhouseCoopers LLP dated May 30, 2008.
  2
  SIGNATURES
  Pursuant to the requirements of
  the Securities Exchange Act of 1934, the Registrant has duly caused this report
  to be signed on its behalf by the undersigned, hereunto duly authorized.
  AFFYMAX, I
  NC
  .
  Dated:
    May 30, 2008
  By:
  /s/ Paul B. Cleveland
  Paul B.
    Cleveland
  Executive Vice President, Corporate
  Development and Chief Financial
  Officer
  3