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  <TITLE> Anadys Pharmaceuticals, Inc. (Form: 8-K) </TITLE>
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  		UNITED STATES<BR>
  	SECURITIES AND EXCHANGE COMMISSION
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  	WASHINGTON, D.C. 20549
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  	FORM 8-K
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  	CURRENT REPORT
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  	Pursuant to Section&nbsp;13 or 15(d) of the Securities Exchange Act of 1934
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  	Date of Report (Date of Earliest Event Reported):
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  	&nbsp;
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  	June 12, 2006
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  	Anadys Pharmaceuticals, Inc.
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  <BR>__________________________________________<BR>
  	(Exact name of registrant as specified in its charter)
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  	Delaware
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  	000-50632
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  	22-3193172
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  _____________________<BR>
  	(State or other jurisdiction
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  _____________<BR>
  	(Commission
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  ______________<BR>
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  	of incorporation)
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  	File Number)
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  	Identification No.)
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  	3115 Merryfield Row, San Diego, California
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  	92121
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  _________________________________<BR>
  	(Address of principal executive offices)
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  ___________<BR>
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  	Registrant&#146;s telephone number, including area code:
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  	(858) 530-3600
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  	Not Applicable
  <BR>______________________________________________<BR>
  	Former name or former address, if changed since last report
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  	&nbsp;
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  <!-- CoverPageRegistrant END --><P><FONT SIZE="2">
  Check the appropriate box below if the Form 8-K filing is intended to
  simultaneously satisfy the filing obligation of the registrant under any
  of the following provisions:</FONT>
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  <P><FONT SIZE="2">
  [&nbsp;&nbsp;]&nbsp;&nbsp;Written communications pursuant to Rule 425 under the Securities Act (17 CFR 230.425)<br>
  [&nbsp;&nbsp;]&nbsp;&nbsp;Soliciting material pursuant to Rule 14a-12 under the Exchange Act (17 CFR 240.14a-12)<br>
  [&nbsp;&nbsp;]&nbsp;&nbsp;Pre-commencement communications pursuant to Rule 14d-2(b) under the Exchange Act (17 CFR 240.14d-2(b))<br>
  [&nbsp;&nbsp;]&nbsp;&nbsp;Pre-commencement communications pursuant to Rule 13e-4(c) under the Exchange Act (17 CFR 240.13e-4(c))<br>
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  <B>
  	Item 1.01 Entry into a Material Definitive Agreement.
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  On June 12, 2006, Kleanthis G. Xanthopoulos, Ph.D. provided notice of his resignation as President and Chief Executive Officer of Anadys Pharmaceuticals, Inc. ("Anadys" or the "Company") effective as of December 31, 2006 or such earlier time as a successor has been identified and appointed. Dr. Xanthopoulos will remain on the Board of Directors following his resignation as President and Chief Executive Officer. The Company has agreed to accelerate in full all of Dr. Xanthopoulos' unvested stock options upon completion of the transition and his resignation as President and Chief Executive Officer. Dr. Xanthopoulos will remain a member of the Board of Directors of the Company following his resignation as President and Chief Executive Officer and as such will continue to be subject to trading restrictions and SEC reporting obligations applicable to transactions involving Anadys stock and options. The Company intends to immediately initiate a search for a replacement President and Chief Executive Officer. <br>
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  	Item 5.02 Departure of Directors or Principal Officers; Election of Directors; Appointment of Principal Officers.
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  Reference is made to Item 1.01 of this Report on Form 8-K.<br> <br><br>
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  	SIGNATURES
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  	Pursuant to the requirements of the Securities Exchange Act of 1934, the
  	registrant has duly caused this report to be signed on its behalf by the
  	undersigned hereunto duly authorized.
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  	Anadys Pharmaceuticals, Inc.
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  <I>
  	June 16, 2006
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  	By:
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  <I>
  	/s/ Elizabeth E. Reed
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  	&nbsp;
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  	Name: Elizabeth E. Reed
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  <I>
  	Title: Senior Director, Legal Affairs and Secretary
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metadata_documents: [{"type": "8-K", "sequence": "1", "filename": "htm_13212.htm", "description": "LIVE FILING", "secsgml_size_bytes": 9624}]
metadata_filer: {"company-data": {"conformed-name": "ANADYS PHARMACEUTICALS INC", "cik": "0001128495", "assigned-sic": "2834", "irs-number": "223193172"}, "filing-values": {"form-type": "8-K", "act": "34", "file-number": "000-50632", "film-number": "06908455"}, "business-address": {"street1": "3115 MERRYFIELD ROW", "city": "SAN DIEGO", "state": "CA", "zip": "92121", "phone": "8585303600"}, "mail-address": {"street1": "3115 MERRYFIELD ROW", "city": "SAN DIEGO", "state": "CA", "zip": "92121"}}
text: Anadys Pharmaceuticals, Inc. (Form: 8-K)
  UNITED STATES
  SECURITIES AND EXCHANGE COMMISSION
  WASHINGTON, D.C. 20549
  FORM 8-K
  CURRENT REPORT
  Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934
  Date of Report (Date of Earliest Event Reported):
  June 12, 2006
  Anadys Pharmaceuticals, Inc.
  __________________________________________
  (Exact name of registrant as specified in its charter)
  Delaware
  000-50632
  22-3193172
  _____________________
  (State or other jurisdiction
  _____________
  (Commission
  ______________
  (I.R.S. Employer
  of incorporation)
  File Number)
  Identification No.)
  3115 Merryfield Row, San Diego, California
  92121
  _________________________________
  (Address of principal executive offices)
  ___________
  (Zip Code)
  Registrant's telephone number, including area code:
  (858) 530-3600
  Not Applicable
  ______________________________________________
  Former name or former address, if changed since last report
  Check the appropriate box below if the Form 8-K filing is intended to
  simultaneously satisfy the filing obligation of the registrant under any
  of the following provisions:
  [  ]  Written communications pursuant to Rule 425 under the Securities Act (17 CFR 230.425)
  [  ]  Soliciting material pursuant to Rule 14a-12 under the Exchange Act (17 CFR 240.14a-12)
  [  ]  Pre-commencement communications pursuant to Rule 14d-2(b) under the Exchange Act (17 CFR 240.14d-2(b))
  [  ]  Pre-commencement communications pursuant to Rule 13e-4(c) under the Exchange Act (17 CFR 240.13e-4(c))
  Top of the Form
  Item 1.01 Entry into a Material Definitive Agreement.
  On June 12, 2006, Kleanthis G. Xanthopoulos, Ph.D. provided notice of his resignation as President and Chief Executive Officer of Anadys Pharmaceuticals, Inc. ("Anadys" or the "Company") effective as of December 31, 2006 or such earlier time as a successor has been identified and appointed. Dr. Xanthopoulos will remain on the Board of Directors following his resignation as President and Chief Executive Officer. The Company has agreed to accelerate in full all of Dr. Xanthopoulos' unvested stock options upon completion of the transition and his resignation as President and Chief Executive Officer. Dr. Xanthopoulos will remain a member of the Board of Directors of the Company following his resignation as President and Chief Executive Officer and as such will continue to be subject to trading restrictions and SEC reporting obligations applicable to transactions involving Anadys stock and options. The Company intends to immediately initiate a search for a replacement President and Chief Executive Officer.
  Item 5.02 Departure of Directors or Principal Officers; Election of Directors; Appointment of Principal Officers.
  Reference is made to Item 1.01 of this Report on Form 8-K.
  Top of the Form
  SIGNATURES
  Pursuant to the requirements of the Securities Exchange Act of 1934, the
  	registrant has duly caused this report to be signed on its behalf by the
  	undersigned hereunto duly authorized.
  Anadys Pharmaceuticals, Inc.
  June 16, 2006
  By:
  /s/ Elizabeth E. Reed
  Name: Elizabeth E. Reed
  Title: Senior Director, Legal Affairs and Secretary