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  <TITLE> Altus Pharmaceuticals Inc. (Form: 8-K) </TITLE>
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  		UNITED STATES<BR>
  	SECURITIES AND EXCHANGE COMMISSION
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  	WASHINGTON, D.C. 20549
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  	FORM 8-K
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  	CURRENT REPORT
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  	Pursuant to Section&nbsp;13 or 15(d) of the Securities Exchange Act of 1934
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  	Date of Report (Date of Earliest Event Reported):
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  	&nbsp;
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  	June 25, 2007
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  	Altus Pharmaceuticals Inc.
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  <BR>__________________________________________<BR>
  	(Exact name of registrant as specified in its charter)
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  	Delaware
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  	0-51711
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  	04-3573277
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  _____________________<BR>
  	(State or other jurisdiction
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  _____________<BR>
  	(Commission
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  ______________<BR>
  	(I.R.S. Employer
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  	of incorporation)
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  	File Number)
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  	Identification No.)
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  	&nbsp;&nbsp;
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  	125 Sidney Street, Cambridge, Massachusetts
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  	02139
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  _________________________________<BR>
  	(Address of principal executive offices)
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  ___________<BR>
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  	Registrant&#146;s telephone number, including area code:
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  	617-299-2900
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  	Not Applicable
  <BR>______________________________________________<BR>
  	Former name or former address, if changed since last report
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  	&nbsp;
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  <!-- CoverPageRegistrant END --><P><FONT SIZE="2">
  Check the appropriate box below if the Form 8-K filing is intended to
  simultaneously satisfy the filing obligation of the registrant under any
  of the following provisions:</FONT>
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  [&nbsp;&nbsp;]&nbsp;&nbsp;Written communications pursuant to Rule 425 under the Securities Act (17 CFR 230.425)<br>
  [&nbsp;&nbsp;]&nbsp;&nbsp;Soliciting material pursuant to Rule 14a-12 under the Exchange Act (17 CFR 240.14a-12)<br>
  [&nbsp;&nbsp;]&nbsp;&nbsp;Pre-commencement communications pursuant to Rule 14d-2(b) under the Exchange Act (17 CFR 240.14d-2(b))<br>
  [&nbsp;&nbsp;]&nbsp;&nbsp;Pre-commencement communications pursuant to Rule 13e-4(c) under the Exchange Act (17 CFR 240.13e-4(c))<br>
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  	Item 1.01 Entry into a Material Definitive Agreement.
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  In August 2006, we entered into a drug production and clinical supply agreement with Althea Technologies, Inc., or Althea. Under this agreement, Althea agreed to modify an existing production facility, and test and validate its manufacturing operations for the production of ALTU-238. The agreement provides for the production of a defined number of manufacturing runs of ALTU-238, from which we intend to supply planned clinical trials. Under the agreement, the parties agreed to prepare a definitive manufacturing project plan and schedule for these activities.  <br><br>On June 25, 2007, the parties entered into an amendment to the agreement that sets forth a modified manufacturing plan and schedule for the project.  In addition, based on the activities conducted to date, the parties agreed to adjust certain prices in the original agreement to compensate Althea for additional services provided and to be provided under the agreement.  The parties also added terms that define a process for future change orders as well as financial terms to compensate Althea for costs associated with future changes to the manufacturing plan and schedule. <br>
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  	SIGNATURES
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  	Pursuant to the requirements of the Securities Exchange Act of 1934, the
  	registrant has duly caused this report to be signed on its behalf by the
  	undersigned hereunto duly authorized.
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  	Altus Pharmaceuticals Inc.
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  <I>
  	June 28, 2007
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  	By:
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  <I>
  	Jonathan I. Lieber
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  <I>
  	Name: Jonathan I. Lieber
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  <I>
  	Title: Vice President, Chief Financial Officer and Treasurer
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metadata_documents: [{"type": "8-K", "sequence": "1", "filename": "htm_21181.htm", "description": "LIVE FILING", "secsgml_size_bytes": 9412}]
metadata_filer: {"company-data": {"conformed-name": "Altus Pharmaceuticals Inc.", "cik": "0001340744", "assigned-sic": "2836", "irs-number": "043573277", "state-of-incorporation": "DE", "fiscal-year-end": "1231"}, "filing-values": {"form-type": "8-K", "act": "34", "file-number": "000-51711", "film-number": "07947791"}, "business-address": {"street1": "125 SIDNEY STREET", "city": "CAMBRIDGE", "state": "MA", "zip": "02139", "phone": "617-299-2900"}, "mail-address": {"street1": "125 SIDNEY STREET", "city": "CAMBRIDGE", "state": "MA", "zip": "02139"}}
text: Altus Pharmaceuticals Inc. (Form: 8-K)
  UNITED STATES
  SECURITIES AND EXCHANGE COMMISSION
  WASHINGTON, D.C. 20549
  FORM 8-K
  CURRENT REPORT
  Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934
  Date of Report (Date of Earliest Event Reported):
  June 25, 2007
  Altus Pharmaceuticals Inc.
  __________________________________________
  (Exact name of registrant as specified in its charter)
  Delaware
  0-51711
  04-3573277
  _____________________
  (State or other jurisdiction
  _____________
  (Commission
  ______________
  (I.R.S. Employer
  of incorporation)
  File Number)
  Identification No.)
  125 Sidney Street, Cambridge, Massachusetts
  02139
  _________________________________
  (Address of principal executive offices)
  ___________
  (Zip Code)
  Registrant's telephone number, including area code:
  617-299-2900
  Not Applicable
  ______________________________________________
  Former name or former address, if changed since last report
  Check the appropriate box below if the Form 8-K filing is intended to
  simultaneously satisfy the filing obligation of the registrant under any
  of the following provisions:
  [  ]  Written communications pursuant to Rule 425 under the Securities Act (17 CFR 230.425)
  [  ]  Soliciting material pursuant to Rule 14a-12 under the Exchange Act (17 CFR 240.14a-12)
  [  ]  Pre-commencement communications pursuant to Rule 14d-2(b) under the Exchange Act (17 CFR 240.14d-2(b))
  [  ]  Pre-commencement communications pursuant to Rule 13e-4(c) under the Exchange Act (17 CFR 240.13e-4(c))
  Top of the Form
  Item 1.01 Entry into a Material Definitive Agreement.
  In August 2006, we entered into a drug production and clinical supply agreement with Althea Technologies, Inc., or Althea. Under this agreement, Althea agreed to modify an existing production facility, and test and validate its manufacturing operations for the production of ALTU-238. The agreement provides for the production of a defined number of manufacturing runs of ALTU-238, from which we intend to supply planned clinical trials. Under the agreement, the parties agreed to prepare a definitive manufacturing project plan and schedule for these activities.
  On June 25, 2007, the parties entered into an amendment to the agreement that sets forth a modified manufacturing plan and schedule for the project.  In addition, based on the activities conducted to date, the parties agreed to adjust certain prices in the original agreement to compensate Althea for additional services provided and to be provided under the agreement.  The parties also added terms that define a process for future change orders as well as financial terms to compensate Althea for costs associated with future changes to the manufacturing plan and schedule.
  Top of the Form
  SIGNATURES
  Pursuant to the requirements of the Securities Exchange Act of 1934, the
  	registrant has duly caused this report to be signed on its behalf by the
  	undersigned hereunto duly authorized.
  Altus Pharmaceuticals Inc.
  June 28, 2007
  By:
  Jonathan I. Lieber
  Name: Jonathan I. Lieber
  Title: Vice President, Chief Financial Officer and Treasurer