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  <TITLE> Neose Technologies, Inc. (Form: 8-K) </TITLE>
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  		UNITED STATES<BR>
  	SECURITIES AND EXCHANGE COMMISSION
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  	WASHINGTON, D.C. 20549
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  	FORM 8-K
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  	CURRENT REPORT
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  	Pursuant to Section&nbsp;13 or 15(d) of the Securities Exchange Act of 1934
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  	Date of Report (Date of Earliest Event Reported):
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  	&nbsp;
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  	February 21, 2006
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  	Neose Technologies, Inc.
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  <BR>__________________________________________<BR>
  	(Exact name of registrant as specified in its charter)
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  	Delaware
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  	000-27718
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  	13-3549286
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  _____________________<BR>
  	(State or other jurisdiction
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  _____________<BR>
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  ______________<BR>
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  	of incorporation)
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  	File Number)
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  	Identification No.)
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  	102 Witmer Road, Horsham, Pennsylvania
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  	19044
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  _________________________________<BR>
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  ___________<BR>
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  	Registrant&#146;s telephone number, including area code:
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  	215-315-9000
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  	Not Applicable
  <BR>______________________________________________<BR>
  	Former name or former address, if changed since last report
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  	&nbsp;
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  <!-- CoverPageRegistrant END --><P><FONT SIZE="2">
  Check the appropriate box below if the Form 8-K filing is intended to
  simultaneously satisfy the filing obligation of the registrant under any
  of the following provisions:</FONT>
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  [&nbsp;&nbsp;]&nbsp;&nbsp;Written communications pursuant to Rule 425 under the Securities Act (17 CFR 230.425)<br>
  [&nbsp;&nbsp;]&nbsp;&nbsp;Soliciting material pursuant to Rule 14a-12 under the Exchange Act (17 CFR 240.14a-12)<br>
  [&nbsp;&nbsp;]&nbsp;&nbsp;Pre-commencement communications pursuant to Rule 14d-2(b) under the Exchange Act (17 CFR 240.14d-2(b))<br>
  [&nbsp;&nbsp;]&nbsp;&nbsp;Pre-commencement communications pursuant to Rule 13e-4(c) under the Exchange Act (17 CFR 240.13e-4(c))<br>
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  	Item 1.01 Entry into a Material Definitive Agreement.
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  On February 21, 2006, Neose Technologies, Inc. (the "Company") entered into an amendment (the "Amendment") to its Research, Development and License Agreement with Novo Nordisk A/S  ("Novo") dated as of November 17, 2003, as previously amended (the "Novo Agreement"). <br><br>	Under the Novo Agreement, the Company is conducting work on next-generation versions of two undisclosed proteins.  The Amendment provides for a two-month extension of a project related deadline with regard to one of the proteins in exchange for the advance, non-refundable payment of certain research costs related to the protein that are expected to be incurred by the Company between the date of the Amendment and the new deadline.<br><br>	The Company does not have any material relationship with Novo Nordisk or its affiliates other than:<br>&#x2022;	in respect of the Novo Agreement and the Amendment; and<br>&#x2022;	in respect of a separate Research, Development and License Agreement with Novo Nordisk A/S and Novo Nordisk Health Care AG, dated November 17, 2003, as amended, under which the Company is conducting work on next-generation versions of a currently marketed Novo protein.<br>
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  	SIGNATURES
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  	Pursuant to the requirements of the Securities Exchange Act of 1934, the
  	registrant has duly caused this report to be signed on its behalf by the
  	undersigned hereunto duly authorized.
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  	Neose Technologies, Inc.
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  <I>
  	February 22, 2006
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  	By:
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  <I>
  	C. Boyd Clarke
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  	Name: C. Boyd Clarke
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  	Title: Chairman and Chief Executive Officer
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metadata_documents: [{"type": "8-K", "sequence": "1", "filename": "htm_10475.htm", "description": "LIVE FILING", "secsgml_size_bytes": 9404}]
metadata_filer: {"company-data": {"conformed-name": "NEOSE TECHNOLOGIES INC", "cik": "0000877902", "assigned-sic": "2833", "irs-number": "133549286", "state-of-incorporation": "DE", "fiscal-year-end": "1231"}, "filing-values": {"form-type": "8-K", "act": "34", "file-number": "000-27718", "film-number": "06639619"}, "business-address": {"street1": "102 WITMER RD", "city": "HORSHAM", "state": "PA", "zip": "19044", "phone": "2154415890"}, "mail-address": {"street1": "102 WITMER ROAD", "city": "HORSHAM", "state": "PA", "zip": "19044"}, "former-company": {"former-conformed-name": "NEOSE PHARMACEUTICALS INC", "date-changed": "19950817"}}
text: Neose Technologies, Inc. (Form: 8-K)
  UNITED STATES
  SECURITIES AND EXCHANGE COMMISSION
  WASHINGTON, D.C. 20549
  FORM 8-K
  CURRENT REPORT
  Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934
  Date of Report (Date of Earliest Event Reported):
  February 21, 2006
  Neose Technologies, Inc.
  __________________________________________
  (Exact name of registrant as specified in its charter)
  Delaware
  000-27718
  13-3549286
  _____________________
  (State or other jurisdiction
  _____________
  (Commission
  ______________
  (I.R.S. Employer
  of incorporation)
  File Number)
  Identification No.)
  102 Witmer Road, Horsham, Pennsylvania
  19044
  _________________________________
  (Address of principal executive offices)
  ___________
  (Zip Code)
  Registrant's telephone number, including area code:
  215-315-9000
  Not Applicable
  ______________________________________________
  Former name or former address, if changed since last report
  Check the appropriate box below if the Form 8-K filing is intended to
  simultaneously satisfy the filing obligation of the registrant under any
  of the following provisions:
  [  ]  Written communications pursuant to Rule 425 under the Securities Act (17 CFR 230.425)
  [  ]  Soliciting material pursuant to Rule 14a-12 under the Exchange Act (17 CFR 240.14a-12)
  [  ]  Pre-commencement communications pursuant to Rule 14d-2(b) under the Exchange Act (17 CFR 240.14d-2(b))
  [  ]  Pre-commencement communications pursuant to Rule 13e-4(c) under the Exchange Act (17 CFR 240.13e-4(c))
  Top of the Form
  Item 1.01 Entry into a Material Definitive Agreement.
  On February 21, 2006, Neose Technologies, Inc. (the "Company") entered into an amendment (the "Amendment") to its Research, Development and License Agreement with Novo Nordisk A/S  ("Novo") dated as of November 17, 2003, as previously amended (the "Novo Agreement").
  Under the Novo Agreement, the Company is conducting work on next-generation versions of two undisclosed proteins.  The Amendment provides for a two-month extension of a project related deadline with regard to one of the proteins in exchange for the advance, non-refundable payment of certain research costs related to the protein that are expected to be incurred by the Company between the date of the Amendment and the new deadline.
  The Company does not have any material relationship with Novo Nordisk or its affiliates other than:
  •	in respect of the Novo Agreement and the Amendment; and
  •	in respect of a separate Research, Development and License Agreement with Novo Nordisk A/S and Novo Nordisk Health Care AG, dated November 17, 2003, as amended, under which the Company is conducting work on next-generation versions of a currently marketed Novo protein.
  Top of the Form
  SIGNATURES
  Pursuant to the requirements of the Securities Exchange Act of 1934, the
  	registrant has duly caused this report to be signed on its behalf by the
  	undersigned hereunto duly authorized.
  Neose Technologies, Inc.
  February 22, 2006
  By:
  C. Boyd Clarke
  Name: C. Boyd Clarke
  Title: Chairman and Chief Executive Officer