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  		UNITED STATES<BR>
  	SECURITIES AND EXCHANGE COMMISSION
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  	WASHINGTON, D.C. 20549
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  	FORM 8-K
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  	CURRENT REPORT
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  	Pursuant to Section&nbsp;13 or 15(d) of the Securities Exchange Act of 1934
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  	Date of Report (Date of Earliest Event Reported):
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  	&nbsp;
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  	May 14, 2006
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  	Illumina, Inc.
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  <BR>__________________________________________<BR>
  	(Exact name of registrant as specified in its charter)
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  	Delaware
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  	000-30361
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  	33-0804655
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  _____________________<BR>
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  _____________<BR>
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  ______________<BR>
  	(I.R.S. Employer
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  	of incorporation)
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  	File Number)
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  	Identification No.)
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  	&nbsp;&nbsp;
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  	9885 Towne Centre Drive, San Diego, California
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  	92121-1975
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  _________________________________<BR>
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  ___________<BR>
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  	Registrant&#146;s telephone number, including area code:
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  	(858) 202-4500
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  	Not Applicable
  <BR>______________________________________________<BR>
  	Former name or former address, if changed since last report
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  	&nbsp;
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  <!-- CoverPageRegistrant END --><P><FONT SIZE="2">
  Check the appropriate box below if the Form 8-K filing is intended to
  simultaneously satisfy the filing obligation of the registrant under any
  of the following provisions:</FONT>
  </P>
  <P><FONT SIZE="2">
  [&nbsp;&nbsp;]&nbsp;&nbsp;Written communications pursuant to Rule 425 under the Securities Act (17 CFR 230.425)<br>
  [&nbsp;&nbsp;]&nbsp;&nbsp;Soliciting material pursuant to Rule 14a-12 under the Exchange Act (17 CFR 240.14a-12)<br>
  [&nbsp;&nbsp;]&nbsp;&nbsp;Pre-commencement communications pursuant to Rule 14d-2(b) under the Exchange Act (17 CFR 240.14d-2(b))<br>
  [&nbsp;&nbsp;]&nbsp;&nbsp;Pre-commencement communications pursuant to Rule 13e-4(c) under the Exchange Act (17 CFR 240.13e-4(c))<br>
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  <B>
  	Item 1.01 Entry into a Material Definitive Agreement.
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  On May 14, 2006, Illumina, Inc. (Illumina) and deCODE genetics, ehf. (deCODE) executed a Joint Development and Licensing Agreement (the Development Agreement).  Pursuant to the Development Agreement, the parties agreed to collaborate exclusively to develop, validate and commercialize specific diagnostic tests for variants in genes involved in three disease-related pathways: the gene-encoding leukotriene A4 hydrolase, linked to heart attack; the gene-encoding transcription factor 7-like 2 (TCF7L2), linked to type 2 diabetes; and the gene-encoding BARD1, linked to breast cancer.  Illumina and deCODE intend to develop these diagnostic tests for use on Illumina&#x2019;s BeadXpress system, which is expected to be launched later this year.<br><br>Under the agreement, Illumina will be responsible for the manufacturing, marketing and selling of the diagnostic products.  The companies must share the development costs of these products and split the profits from sales of the diagnostics tests.<br><br>The Development Agreement may be terminated as to a particular product under development if one party decides to discontinue funding the development of that product, and may be terminated in whole by either party if the other party commits an uncured material breach, files for bankruptcy or becomes insolvent.<br><br>Under a separate supply agreement, Illumina will install instrumentation at deCODE which will enable deCODE to perform whole genome association studies on up to 100,000 samples using Illumina&#x2019;s HumanHap300 BeadChips and associated reagents.<br><br>The above description of the Development Agreement is qualified in its entirety to the terms of the Development Agreement, a copy of which Illumina plans to file with the Securities and Exchange Commission as an exhibit to its next quarterly report on Form 10-Q.<br>
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  	SIGNATURES
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  	Pursuant to the requirements of the Securities Exchange Act of 1934, the
  	registrant has duly caused this report to be signed on its behalf by the
  	undersigned hereunto duly authorized.
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  	Illumina, Inc.
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  <I>
  	May 18, 2006
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  	By:
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  <I>
  	/s/ Christian O. Henry
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  <I>
  	Name: Christian O. Henry
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  <I>
  	Title: Vice President and Chief Financial Officer
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metadata_documents: [{"type": "8-K", "sequence": "1", "filename": "htm_12592.htm", "description": "LIVE FILING", "secsgml_size_bytes": 10071}]
metadata_filer: {"company-data": {"conformed-name": "ILLUMINA INC", "cik": "0001110803", "assigned-sic": "3826", "irs-number": "330804655", "state-of-incorporation": "DE", "fiscal-year-end": "0101"}, "filing-values": {"form-type": "8-K", "act": "34", "file-number": "000-30361", "film-number": "06851291"}, "business-address": {"street1": "9885 TOWNE CENTRE DRIVE", "city": "SAN DIEGO", "state": "CA", "zip": "92121", "phone": "8582024500"}, "mail-address": {"street1": "9885 TOWNE CENTRE DRIVE", "city": "SAN DIEGO", "state": "CA", "zip": "92121"}}
text: Illumina, Inc. (Form: 8-K)
  UNITED STATES
  SECURITIES AND EXCHANGE COMMISSION
  WASHINGTON, D.C. 20549
  FORM 8-K
  CURRENT REPORT
  Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934
  Date of Report (Date of Earliest Event Reported):
  May 14, 2006
  Illumina, Inc.
  __________________________________________
  (Exact name of registrant as specified in its charter)
  Delaware
  000-30361
  33-0804655
  _____________________
  (State or other jurisdiction
  _____________
  (Commission
  ______________
  (I.R.S. Employer
  of incorporation)
  File Number)
  Identification No.)
  9885 Towne Centre Drive, San Diego, California
  92121-1975
  _________________________________
  (Address of principal executive offices)
  ___________
  (Zip Code)
  Registrant's telephone number, including area code:
  (858) 202-4500
  Not Applicable
  ______________________________________________
  Former name or former address, if changed since last report
  Check the appropriate box below if the Form 8-K filing is intended to
  simultaneously satisfy the filing obligation of the registrant under any
  of the following provisions:
  [  ]  Written communications pursuant to Rule 425 under the Securities Act (17 CFR 230.425)
  [  ]  Soliciting material pursuant to Rule 14a-12 under the Exchange Act (17 CFR 240.14a-12)
  [  ]  Pre-commencement communications pursuant to Rule 14d-2(b) under the Exchange Act (17 CFR 240.14d-2(b))
  [  ]  Pre-commencement communications pursuant to Rule 13e-4(c) under the Exchange Act (17 CFR 240.13e-4(c))
  Top of the Form
  Item 1.01 Entry into a Material Definitive Agreement.
  On May 14, 2006, Illumina, Inc. (Illumina) and deCODE genetics, ehf. (deCODE) executed a Joint Development and Licensing Agreement (the Development Agreement).  Pursuant to the Development Agreement, the parties agreed to collaborate exclusively to develop, validate and commercialize specific diagnostic tests for variants in genes involved in three disease-related pathways: the gene-encoding leukotriene A4 hydrolase, linked to heart attack; the gene-encoding transcription factor 7-like 2 (TCF7L2), linked to type 2 diabetes; and the gene-encoding BARD1, linked to breast cancer.  Illumina and deCODE intend to develop these diagnostic tests for use on Illumina's BeadXpress system, which is expected to be launched later this year.
  Under the agreement, Illumina will be responsible for the manufacturing, marketing and selling of the diagnostic products.  The companies must share the development costs of these products and split the profits from sales of the diagnostics tests.
  The Development Agreement may be terminated as to a particular product under development if one party decides to discontinue funding the development of that product, and may be terminated in whole by either party if the other party commits an uncured material breach, files for bankruptcy or becomes insolvent.
  Under a separate supply agreement, Illumina will install instrumentation at deCODE which will enable deCODE to perform whole genome association studies on up to 100,000 samples using Illumina's HumanHap300 BeadChips and associated reagents.
  The above description of the Development Agreement is qualified in its entirety to the terms of the Development Agreement, a copy of which Illumina plans to file with the Securities and Exchange Commission as an exhibit to its next quarterly report on Form 10-Q.
  Top of the Form
  SIGNATURES
  Pursuant to the requirements of the Securities Exchange Act of 1934, the
  	registrant has duly caused this report to be signed on its behalf by the
  	undersigned hereunto duly authorized.
  Illumina, Inc.
  May 18, 2006
  By:
  /s/ Christian O. Henry
  Name: Christian O. Henry
  Title: Vice President and Chief Financial Officer