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  <p style="border:none;margin:0in 0in .0001pt;padding:0in;text-align:justify;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>
  
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  <p align="center" style="margin:0in 0in .0001pt;text-align:center;"><b><font size="5" face="Times New Roman" style="font-size:18.0pt;font-weight:bold;">UNITED
  STATES<br>
  SECURITIES AND EXCHANGE COMMISSION</font></b></p>
  
  <p align="center" style="margin:0in 0in .0001pt;text-align:center;"><b><font size="2" face="Times New Roman" style="font-size:10.0pt;font-weight:bold;">Washington,
  DC&#160; 20549</font></b></p>
  
  <p align="center" style="margin:0in 0in .0001pt;text-align:center;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>
  
  <div align="center" style="margin:0in 0in .0001pt;text-align:center;"><hr size="1" width="25%" noshade color="black" align="center"></div>
  
  <p align="center" style="margin:0in 0in .0001pt;text-align:center;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>
  
  <p align="center" style="margin:0in 0in .0001pt;text-align:center;"><b><font size="5" face="Times New Roman" style="font-size:18.0pt;font-weight:bold;">FORM&nbsp;8-K</font></b></p>
  
  <p align="center" style="margin:0in 0in .0001pt;text-align:center;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>
  
  <p align="center" style="margin:0in 0in .0001pt;text-align:center;"><b><font size="3" face="Times New Roman" style="font-size:12.0pt;font-weight:bold;">CURRENT
  REPORT</font></b></p>
  
  <p align="center" style="margin:0in 0in .0001pt;text-align:center;"><b><font size="3" face="Times New Roman" style="font-size:12.0pt;font-weight:bold;">Pursuant
  to Section&nbsp;13 or 15(d)&nbsp;of the<br>
  Securities Exchange Act of 1934</font></b></p>
  
  <p align="center" style="margin:0in 0in .0001pt;text-align:center;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>
  
  <p align="center" style="margin:0in 0in .0001pt;text-align:center;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">Date of Report
  (Date of earliest event reported):&#160; <b>May&nbsp;7, 2008</b></font></p>
  
  <p align="center" style="margin:0in 0in .0001pt;text-align:center;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>
  
  <p style="font-weight:bold;margin:0in 0in .0001pt;text-align:center;text-transform:uppercase;"><b><font size="5" face="Times New Roman" style="font-size:18.0pt;text-transform:none;">GENOPTIX, INC.</font></b></p>
  
  <p align="center" style="margin:0in 0in .0001pt;text-align:center;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">(Exact name of
  registrant as specified in its charter)</font></p>
  
  <p style="margin:0in 0in .0001pt;text-align:justify;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>
  
  <div align="center">
  
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   <tr>
    <td width="32%" valign="top" style="padding:0in 0in 0in 0in;width:32.0%;">
    <p align="center" style="margin:0in 0in .0001pt;text-align:center;"><b><font size="2" face="Times New Roman" style="font-size:10.0pt;font-weight:bold;">Delaware</font></b></p>
    </td>
    <td width="2%" valign="bottom" style="padding:0in 0in 0in 0in;width:2.0%;">
    <p align="left" style="margin:0in 0in .0001pt;text-align:left;"><b><font size="2" face="Times New Roman" style="font-size:1.0pt;font-weight:bold;">&nbsp;</font></b></p>
    </td>
    <td width="32%" valign="top" style="padding:0in 0in 0in 0in;width:32.0%;">
    <p align="center" style="margin:0in 0in .0001pt;text-align:center;"><b><font size="2" face="Times New Roman" style="font-size:10.0pt;font-weight:bold;">001-33753</font></b></p>
    </td>
    <td width="2%" valign="bottom" style="padding:0in 0in 0in 0in;width:2.0%;">
    <p align="left" style="margin:0in 0in .0001pt;text-align:left;"><b><font size="2" face="Times New Roman" style="font-size:1.0pt;font-weight:bold;">&nbsp;</font></b></p>
    </td>
    <td width="32%" valign="top" style="padding:0in 0in 0in 0in;width:32.0%;">
    <p align="center" style="margin:0in 0in .0001pt;text-align:center;"><b><font size="2" face="Times New Roman" style="font-size:10.0pt;font-weight:bold;">33-0840570</font></b></p>
    </td>
   </tr>
   <tr>
    <td width="32%" valign="top" style="padding:0in 0in 0in 0in;width:32.0%;">
    <p align="center" style="margin:0in 0in .0001pt;text-align:center;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">(State or other
    jurisdiction of<br>
    incorporation)</font></p>
    </td>
    <td width="2%" valign="bottom" style="padding:0in 0in 0in 0in;width:2.0%;">
    <p align="left" style="margin:0in 0in .0001pt;text-align:left;"><font size="2" face="Times New Roman" style="font-size:1.0pt;">&nbsp;</font></p>
    </td>
    <td width="32%" valign="top" style="padding:0in 0in 0in 0in;width:32.0%;">
    <p align="center" style="margin:0in 0in .0001pt;text-align:center;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">(Commission File
    Number)</font></p>
    </td>
    <td width="2%" valign="bottom" style="padding:0in 0in 0in 0in;width:2.0%;">
    <p align="left" style="margin:0in 0in .0001pt;text-align:left;"><font size="2" face="Times New Roman" style="font-size:1.0pt;">&nbsp;</font></p>
    </td>
    <td width="32%" valign="top" style="padding:0in 0in 0in 0in;width:32.0%;">
    <p align="center" style="margin:0in 0in .0001pt;text-align:center;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">(I.R.S. Employer
    Identification<br>
    No.)</font></p>
    </td>
   </tr>
  </table>
  
  </div>
  
  <p align="center" style="margin:0in 0in .0001pt;text-align:center;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>
  
  <p align="center" style="margin:0in 0in .0001pt;text-align:center;"><b><font size="2" face="Times New Roman" style="font-size:10.0pt;font-weight:bold;">2110
  Rutherford Road</font></b></p>
  
  <p align="center" style="margin:0in 0in .0001pt;text-align:center;"><b><font size="2" face="Times New Roman" style="font-size:10.0pt;font-weight:bold;">Carlsbad,
  CA 92008</font></b></p>
  
  <p align="center" style="margin:0in 0in .0001pt;text-align:center;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">(Address of principal
  executive offices and zip code)</font></p>
  
  <p align="center" style="margin:0in 0in .0001pt;text-align:center;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>
  
  <p align="center" style="font-size:10.0pt;margin:0in 0in .0001pt;text-align:center;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">Registrant&#146;s
  telephone number, including area code: </font><b>(760) 268-6200</b></p>
  
  <p align="center" style="margin:0in 0in .0001pt;text-align:center;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>
  
  <div align="center" style="margin:0in 0in .0001pt;text-align:center;"><hr size="1" width="25%" noshade color="black" align="center"></div>
  
  <p align="center" style="margin:0in 0in .0001pt;text-align:center;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>
  
  <p style="margin:0in 0in .0001pt;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">Check
  the appropriate box below if the Form&nbsp;8-K filing is intended to
  simultaneously satisfy the filing obligation of the registrant under any of the
  following provisions:</font></p>
  
  <p style="margin:0in 0in .0001pt;"><font size="2" face="Times New Roman">&nbsp;</font></p>
  
  <p style="font-size:10.0pt;margin:0in 0in .0001pt;"><font size="2" face="Wingdings" style="font-size:10.0pt;">&#168;</font> Written communications pursuant to Rule&nbsp;425
  under the Securities Act (17 CFR 230.425)</p>
  
  <p style="margin:0in 0in .0001pt;"><font size="2" face="Times New Roman">&nbsp;</font></p>
  
  <p style="font-size:10.0pt;margin:0in 0in .0001pt;"><font size="2" face="Wingdings" style="font-size:10.0pt;">&#168;</font> Soliciting material pursuant to Rule&nbsp;14a-12
  under the Exchange Act (17 CFR 240.14a-12)</p>
  
  <p style="margin:0in 0in .0001pt;"><font size="2" face="Times New Roman">&nbsp;</font></p>
  
  <p style="font-size:10.0pt;margin:0in 0in .0001pt;"><font size="2" face="Wingdings" style="font-size:10.0pt;">&#168;</font> Pre-commencement communications pursuant to Rule&nbsp;14d-2(b)&nbsp;under
  the Exchange Act (17 CFR 240.14d-2(b))</p>
  
  <p style="margin:0in 0in .0001pt;"><font size="2" face="Times New Roman">&nbsp;</font></p>
  
  <p style="font-size:10.0pt;margin:0in 0in .0001pt;"><font size="2" face="Wingdings" style="font-size:10.0pt;">&#168;</font> Pre-commencement communications pursuant to Rule&nbsp;13e-4(c)&nbsp;under
  the Exchange Act (17 CFR 240.13e-4(c))</p>
  
  <div style="border:none;border-bottom:double windowtext 6.0pt;padding:0in 0in 0in 0in;">
  
  <p style="border:none;margin:0in 0in .0001pt;padding:0in;"><font size="2" face="Times New Roman">&nbsp;</font></p>
  
  </div>
  
  <p align="center" style="margin:0in 0in .0001pt;text-align:center;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>
  
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  <div>
  
  <p align="center" style="margin:0in 0in .0001pt;text-align:center;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>
  
  <p align="left" style="margin:0in 0in .0001pt;text-align:left;"><b><font size="2" face="Times New Roman" style="font-size:10.0pt;font-weight:bold;">Item 8.01.&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; Other
  Events.</font></b></p>
  
  <p align="left" style="margin:0in 0in .0001pt;text-align:left;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>
  
  <p style="margin:0in 0in .0001pt;text-indent:.5in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">On May 7, 2008, the Board of Directors (the &#147;Board&#148;) of Genoptix, Inc.
  (&#147;Genoptix&#148;), following the recommendation of the Compensation Committee of the
  Board, approved certain changes to the Genoptix Non-Employee Director
  Compensation Policy (the &#147;Compensation Policy&#148;) and certain related amendments
  to the 2007 Non-employee Directors&#146; Stock Option Plan (&#147;2007 NEDSOP&#148;).&#160; The Compensation Committee and the Board
  reviewed the Compensation Policy and the proposed amendments to the 2007 NEDSOP
  in conjunction with information provided by an independent compensation
  consultant. The amended Compensation Policy provides that each member of Board
  will receive an annual fee of $35,000.&#160;
  The amended Compensation Policy also provides that each member of the
  Compensation Committee and Compliance Committee will receive an annual fee of
  $5,000, each member of the Nominating and Corporate Governance Committee will
  receive an annual fee of $2,500, and each member of the Audit Committee will
  receive an annual fee of $7,500, in each case for service as a member of such
  committees.&#160; Additionally, the amended
  Compensation Policy provides that the chair of the Audit Committee will receive
  $15,000 per year for services, and the chair of the Nominating and Corporate
  Governance Committee will receive $5,000 per year for services. Previously, no
  fees were paid for committee membership other than for service as the chair of
  the Audit, Compensation or Compliance committee. No changes were made to the
  cash compensation for the chair of the Board or for committee service payable
  to the chairs of the Compliance Committee and Compensation Committee.</font></p>
  
  <p style="margin:0in 0in .0001pt;"><font size="2" face="Times New Roman">&nbsp;</font></p>
  
  <p style="margin:0in 0in .0001pt;text-indent:.5in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">In addition to the changes to cash compensation, the Board, following
  the recommendation of the Compensation Committee, further amended the Compensation Policy by amending the 2007
  NEDSOP to reduce the initial nonqualified stock option grant each new
  director receives under the 2007 NEDSOP
  in connection with his or her election to the Board from 25,000 shares to 10,000 shares of common stock and approving
  the grant to each new director of a restricted stock unit (&#147;RSU&#148;) award for
  5,000 shares of common stock under the 2007 Equity Incentive Plan (&#147;2007 EIP&#148;),
  with such RSU award being made concurrently with the initial stock option grant
  under the 2007 NEDSOP.&#160; The Board,
  following the recommendation of the Compensation Committee, also approved an
  amendment to the 2007 NEDSOP to reduce the
  annual nonqualified stock option grant to be made to each director under the
  2007 NEDSOP from 10,000 shares to 3,750 shares of common stock and
  approved granting, concurrently with such reduced annual grant under the 2007
  NEDSOP, an annual RSU award for 2,500 shares of common stock under the 2007
  EIP, with such annual grants to be made to each director at each Genoptix
  annual stockholders meeting.&#160; The Board
  also approved that the initial grant will be doubled for a newly elected non-employee
  director who at such time is elected to serve as the chair of the Board and the
  annual grant will be doubled for a non-employee director serving as the chair
  of the Board.&#160; Each of the nonqualified
  stock options granted pursuant to the Compensation Plan will be made in
  accordance with the provisions of the 2007 NEDSOP and the RSUs will be made in
  accordance with the provisions of the 2007 EIP.&#160;
  Initial awards vest over three years and annual awards vest over twelve
  months, with monthly vesting from the date of grant for the nonqualified stock
  option portion of each award and quarterly vesting from the date of grant for
  the RSU portion of each award. The initial and annual RSU awards will be
  granted pursuant to a form of RSU Award Agreement for Directors, which will
  contain the same acceleration of vesting provisions upon a change in control as
  those set forth in the nonqualified stock option awards granted under the 2007
  NEDSOP to the non-employee directors.</font></p>
  
  <p style="margin:0in 0in .0001pt;text-indent:.5in;"><font size="2" face="Times New Roman">&nbsp;</font></p>
  
  <p align="left" style="margin:0in 0in .0001pt;text-align:left;text-autospace:none;text-indent:.5in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">The text of the
  Compensation Policy, as amended, is attached as Exhibit&nbsp;99.1 to
  this Current Report and is incorporated by reference herein.</font></p>
  
  <p align="left" style="margin:0in 0in .0001pt;text-align:left;text-autospace:none;text-indent:.5in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>
  
  <p align="left" style="margin:0in 0in .0001pt;text-align:left;text-autospace:none;text-indent:.5in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&#160; The Board, following the recommendation of
  the Compensation Committee, also approved one-time equity awards to existing
  non-employee directors. The Board approved granting each non-employee
  member of the Board a&#160; nonqualified stock
  option to purchase 10,000 shares of common stock and a RSU award for 5,000
  shares of common stock, each to be granted on the date of the Genoptix 2008
  annual stockholders meeting.&#160; The Board
  approved granting the chair of the Board a one-time equity grant equal to twice
  the number of nonqualified stock options and RSUs granted to the other
  non-employee members </font></p>
  
  <p align="center" style="margin:0in 0in .0001pt;text-align:center;text-autospace:none;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>
  
  <p align="center" style="margin:0in 0in .0001pt;text-align:center;text-autospace:none;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">2</font></p>
  
  <div align="left" style="margin:0in 0in .0001pt;text-align:left;text-autospace:none;"><hr size="3" width="100%" noshade color="#010101" align="left"></div>
  
  </div>
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  <br clear="all" style="page-break-before:always;">
  
  
  <div style="font-family:Times New Roman;">
  
  <p align="center" style="margin:0in 0in .0001pt;text-align:center;text-autospace:none;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>
  
  <p align="left" style="margin:0in 0in .0001pt;text-align:left;text-autospace:none;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">of the Board for his service as the chair of the Board. These equity
  awards will be made pursuant to the 2007 EIP and will vest over three years,
  with the options vesting in equal months installments and the RSUs vesting in
  equal quarterly installments.&#160; The RSU
  portion of these awards will be granted pursuant to the same form of RSU Award
  Agreement for Directors and will contain the same acceleration of vesting
  provisions as the initial and annual nonqualified stock option awards granted
  under the 2007 NEDSOP.&#160; The exercise
  price of the options will be the fair market value of Genoptix common stock on
  the date of the annual stockholder meeting as determined under the 2007
  EIP.&#160;&#160; These one-time awards were
  intended to align the equity awards granted to existing non-employee directors
  with the equity awards that will be granted to any new non-employee member of
  the Board.</font></p>
  
  <p align="left" style="margin:0in 0in .0001pt;text-align:left;text-autospace:none;text-indent:.5in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>
  
  <p align="left" style="font-weight:bold;margin:0in 0in .0001pt;page-break-after:avoid;text-align:left;"><b><font size="2" face="Times New Roman" style="font-size:10.0pt;">Item 9.01.&#160;&#160;&#160;&#160;&#160; Financial
  Statements and Exhibits.</font></b></p>
  
  <p align="left" style="font-weight:bold;margin:0in 0in .0001pt;page-break-after:avoid;text-align:left;"><b><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></b></p>
  
  <p align="left" style="margin:0in 0in .0001pt;text-align:left;"><i><font size="2" face="Times New Roman" style="font-size:10.0pt;font-style:italic;">(d)&nbsp;Exhibits</font></i></p>
  
  <p align="left" style="margin:0in 0in .0001pt;text-align:left;"><i><font size="2" face="Times New Roman" style="font-size:10.0pt;font-style:italic;">&nbsp;</font></i></p>
  
  <table border="0" cellspacing="0" cellpadding="0" width="100%" style="border-collapse:collapse;width:100.0%;">
   <tr>
    <td width="5%" valign="top" style="padding:0in 0in 0in 0in;width:5.66%;">
    <p align="left" style="margin:0in 0in .0001pt;text-align:left;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;&nbsp;99.1</font></p>
    </td>
    <td width="0%" valign="bottom" style="padding:0in 0in 0in 0in;width:.84%;">
    <p align="left" style="margin:0in 0in .0001pt;text-align:left;"><font size="2" face="Times New Roman" style="font-size:1.0pt;">&nbsp;</font></p>
    </td>
    <td width="93%" valign="top" style="padding:0in 0in 0in 0in;width:93.5%;">
    <p align="left" style="font-size:10.0pt;margin:0in 0in .0001pt;text-align:left;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">Non-Employee Director Compensation Policy</font>, as amended.</p>
    </td>
   </tr>
   <tr>
    <td width="5%" valign="top" style="padding:0in 0in 0in 0in;width:5.66%;">
    <p align="left" style="margin:0in 0in .0001pt;text-align:left;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>
    </td>
    <td width="0%" valign="bottom" style="padding:0in 0in 0in 0in;width:.84%;">
    <p align="left" style="margin:0in 0in .0001pt;text-align:left;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>
    </td>
    <td width="93%" valign="top" style="padding:0in 0in 0in 0in;width:93.5%;">
    <p align="left" style="margin:0in 0in .0001pt;text-align:left;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>
    </td>
   </tr>
   <tr>
    <td width="5%" valign="top" style="padding:0in 0in 0in 0in;width:5.66%;">
    <p align="left" style="margin:0in 0in .0001pt;text-align:left;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;&nbsp;99.2</font></p>
    </td>
    <td width="0%" valign="bottom" style="padding:0in 0in 0in 0in;width:.84%;">
    <p align="left" style="margin:0in 0in .0001pt;text-align:left;"><font size="2" face="Times New Roman" style="font-size:1.0pt;">&nbsp;</font></p>
    </td>
    <td width="93%" valign="top" style="padding:0in 0in 0in 0in;width:93.5%;">
    <p align="left" style="margin:0in 0in .0001pt;text-align:left;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">2007 Non-Employee Directors&#146; Stock Option
    Plan, as amended.</font></p>
    </td>
   </tr>
  </table>
  
  <p align="center" style="margin:0in 0in .0001pt;text-align:center;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>
  
  <p align="center" style="margin:0in 0in .0001pt;text-align:center;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">3</font></p>
  
  <div align="left" style="margin:0in 0in .0001pt;text-align:left;"><hr size="3" width="100%" noshade color="#010101" align="left"></div>
  
  </div>
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  <br clear="all" style="page-break-before:always;">
  
  
  <div style="font-family:Times New Roman;">
  
  <p align="center" style="margin:0in 0in .0001pt;text-align:center;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>
  
  <p style="font-weight:bold;margin:0in 0in .0001pt;page-break-after:avoid;text-align:center;"><b><font size="2" face="Times New Roman" style="font-size:10.0pt;font-variant:normal !important;">SIGNATURE</font></b></p>
  
  <p style="font-weight:bold;margin:0in 0in .0001pt;page-break-after:avoid;text-align:center;"><b><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></b></p>
  
  <p align="left" style="margin:0in 0in .0001pt;text-align:left;text-indent:.5in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">Pursuant to the requirements
  of the Securities Exchange Act of 1934, the registrant has duly caused this
  report to be signed on its behalf by the undersigned, thereunto duly
  authorized.</font></p>
  
  <p align="left" style="margin:0in 0in .0001pt;text-align:left;text-indent:.5in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>
  
  <p align="center" style="margin:0in 0in .0001pt;text-align:center;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>
  
  <table border="0" cellspacing="0" cellpadding="0" width="100%" style="border-collapse:collapse;width:100.0%;">
   <tr>
    <td width="50%" valign="top" style="padding:0in 0in 0in 0in;width:50.58%;">
    <p align="left" style="margin:0in 0in .0001pt;text-align:left;"><font size="2" face="Times New Roman" style="font-size:1.0pt;">&nbsp;</font></p>
    </td>
    <td width="49%" colspan="2" valign="top" style="padding:0in 0in 0in 0in;width:49.42%;">
    <p align="left" style="margin:0in 0in .0001pt;text-align:left;"><b><font size="2" face="Times New Roman" style="font-size:10.0pt;font-weight:bold;">GENOPTIX, INC.</font></b></p>
    </td>
   </tr>
   <tr>
    <td width="50%" valign="top" style="padding:0in 0in 0in 0in;width:50.58%;">
    <p align="left" style="margin:0in 0in .0001pt;text-align:left;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>
    </td>
    <td width="3%" valign="bottom" style="padding:0in 0in 0in 0in;width:3.58%;">
    <p align="left" style="margin:0in 0in .0001pt;text-align:left;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>
    </td>
    <td width="45%" valign="top" style="padding:0in 0in 0in 0in;width:45.84%;">
    <p align="left" style="margin:0in 0in .0001pt;text-align:left;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>
    </td>
   </tr>
   <tr>
    <td width="50%" valign="top" style="padding:0in 0in 0in 0in;width:50.58%;">
    <p align="left" style="margin:0in 0in .0001pt;text-align:left;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>
    </td>
    <td width="3%" valign="bottom" style="padding:0in 0in 0in 0in;width:3.58%;">
    <p align="left" style="margin:0in 0in .0001pt;text-align:left;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>
    </td>
    <td width="45%" valign="top" style="padding:0in 0in 0in 0in;width:45.84%;">
    <p align="left" style="margin:0in 0in .0001pt;text-align:left;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>
    </td>
   </tr>
   <tr>
    <td width="50%" valign="top" style="padding:0in 0in 0in 0in;width:50.58%;">
    <p align="left" style="margin:0in 0in .0001pt;text-align:left;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">Dated:&nbsp;&nbsp;May&nbsp;13, 2008</font></p>
    </td>
    <td width="3%" valign="top" style="padding:0in 0in 0in 0in;width:3.58%;">
    <p align="left" style="margin:0in 0in .0001pt;text-align:left;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">By:</font></p>
    </td>
    <td width="45%" valign="top" style="border:none;border-bottom:solid windowtext 1.0pt;padding:0in 0in 0in 0in;width:45.84%;">
    <p align="left" style="font-size:10.0pt;margin:0in 0in .0001pt;text-align:left;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">/s/ </font>Christian V. Kuhlen, M.D.,&nbsp;Esq.</p>
    </td>
   </tr>
   <tr>
    <td width="50%" valign="top" style="padding:0in 0in 0in 0in;width:50.58%;">
    <p align="left" style="margin:0in 0in .0001pt;text-align:left;"><font size="2" face="Times New Roman" style="font-size:1.0pt;">&nbsp;</font></p>
    </td>
    <td width="3%" valign="bottom" style="padding:0in 0in 0in 0in;width:3.58%;">
    <p align="left" style="margin:0in 0in .0001pt;text-align:left;"><font size="2" face="Times New Roman" style="font-size:1.0pt;">&nbsp;</font></p>
    </td>
    <td width="45%" valign="top" style="border:none;padding:0in 0in 0in 0in;width:45.84%;">
    <p align="left" style="margin:0in 0in .0001pt;text-align:left;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">Christian V. Kuhlen, M.D.,&nbsp;Esq.</font></p>
    </td>
   </tr>
   <tr>
    <td width="50%" valign="top" style="padding:0in 0in 0in 0in;width:50.58%;">
    <p align="left" style="margin:0in 0in .0001pt;text-align:left;"><font size="2" face="Times New Roman" style="font-size:1.0pt;">&nbsp;</font></p>
    </td>
    <td width="3%" valign="bottom" style="padding:0in 0in 0in 0in;width:3.58%;">
    <p align="left" style="margin:0in 0in .0001pt;text-align:left;"><font size="2" face="Times New Roman" style="font-size:1.0pt;">&nbsp;</font></p>
    </td>
    <td width="45%" valign="top" style="padding:0in 0in 0in 0in;width:45.84%;">
    <p align="left" style="margin:0in 0in .0001pt;text-align:left;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">Vice President, General Counsel</font></p>
    </td>
   </tr>
  </table>
  
  <p align="center" style="margin:0in 0in .0001pt;text-align:center;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>
  
  <p align="center" style="margin:0in 0in .0001pt;text-align:center;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">4</font></p>
  
  <div align="left" style="margin:0in 0in .0001pt;text-align:left;"><hr size="3" width="100%" noshade color="#010101" align="left"></div>
  
  </div>
  <!-- SEQ.=1,FOLIO='4',FILE='C:\JMS\brosent\08-14285-1\task2937504\14285-1-ba-01.htm',USER='brosent',CD='May 13 14:39 2008' -->
  
  
  <br clear="all" style="page-break-before:always;">
  
  
  <div style="font-family:Times New Roman;">
  
  <p align="center" style="margin:0in 0in .0001pt;text-align:center;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>
  
  <p style="font-weight:bold;margin:0in 0in .0001pt;page-break-after:avoid;text-align:center;"><b><font size="2" face="Times New Roman" style="font-size:10.0pt;font-variant:normal !important;">EXHIBIT
  INDEX</font></b></p>
  
  <p align="left" style="margin:0in 0in .0001pt;text-align:left;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>
  
  <table border="0" cellspacing="0" cellpadding="0" width="100%" style="border-collapse:collapse;width:100.0%;">
   <tr>
    <td width="7%" valign="bottom" style="padding:0in 0in 0in 0in;width:7.5%;">
    <p align="left" style="margin:0in 0in .0001pt;text-align:left;"><b><font size="1" face="Times New Roman" style="font-size:8.0pt;font-weight:bold;">Exhibit</font></b></p>
    </td>
    <td width="3%" valign="bottom" style="padding:0in 0in 0in 0in;width:3.1%;">
    <p align="center" style="margin:0in 0in .0001pt;text-align:center;"><b><font size="1" face="Times New Roman" style="font-size:1.0pt;font-weight:bold;">&nbsp;</font></b></p>
    </td>
    <td width="89%" valign="bottom" style="padding:0in 0in 0in 0in;width:89.4%;">
    <p align="center" style="margin:0in 0in .0001pt;text-align:center;"><b><font size="1" face="Times New Roman" style="font-size:1.0pt;font-weight:bold;">&nbsp;</font></b></p>
    </td>
   </tr>
   <tr>
    <td width="7%" valign="bottom" style="border:none;border-bottom:solid windowtext 1.0pt;padding:0in 0in 0in 0in;width:7.5%;">
    <p align="left" style="margin:0in 0in .0001pt;text-align:left;"><b><font size="1" face="Times New Roman" style="font-size:8.0pt;font-weight:bold;">Number</font></b></p>
    </td>
    <td width="3%" valign="bottom" style="padding:0in 0in 0in 0in;width:3.1%;">
    <p align="center" style="margin:0in 0in .0001pt;text-align:center;"><b><font size="1" face="Times New Roman" style="font-size:1.0pt;font-weight:bold;">&nbsp;</font></b></p>
    </td>
    <td width="89%" valign="bottom" style="border:none;border-bottom:solid windowtext 1.0pt;padding:0in 0in 0in 0in;width:89.4%;">
    <p align="center" style="margin:0in 0in .0001pt;text-align:center;"><b><font size="1" face="Times New Roman" style="font-size:8.0pt;font-weight:bold;">Description</font></b></p>
    </td>
   </tr>
   <tr>
    <td width="7%" valign="top" style="border:none;padding:0in 0in 0in 0in;width:7.5%;">
    <p align="left" style="margin:0in 0in .0001pt;text-align:left;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">99.1</font></p>
    </td>
    <td width="3%" valign="bottom" style="padding:0in 0in 0in 0in;width:3.1%;">
    <p align="left" style="margin:0in 0in .0001pt;text-align:left;"><font size="2" face="Times New Roman" style="font-size:1.0pt;">&nbsp;</font></p>
    </td>
    <td width="89%" valign="top" style="border:none;padding:0in 0in 0in 0in;width:89.4%;">
    <p align="left" style="font-size:10.0pt;margin:0in 0in .0001pt;text-align:left;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">Non-Employee Director Compensation Policy</font>, as amended.</p>
    </td>
   </tr>
   <tr>
    <td width="7%" valign="top" style="padding:0in 0in 0in 0in;width:7.5%;">
    <p align="left" style="margin:0in 0in .0001pt;text-align:left;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>
    </td>
    <td width="3%" valign="bottom" style="padding:0in 0in 0in 0in;width:3.1%;">
    <p align="left" style="margin:0in 0in .0001pt;text-align:left;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>
    </td>
    <td width="89%" valign="top" style="padding:0in 0in 0in 0in;width:89.4%;">
    <p align="left" style="margin:0in 0in .0001pt;text-align:left;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>
    </td>
   </tr>
   <tr>
    <td width="7%" valign="top" style="padding:0in 0in 0in 0in;width:7.5%;">
    <p align="left" style="margin:0in 0in .0001pt;text-align:left;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">99.2</font></p>
    </td>
    <td width="3%" valign="bottom" style="padding:0in 0in 0in 0in;width:3.1%;">
    <p align="left" style="margin:0in 0in .0001pt;text-align:left;"><font size="2" face="Times New Roman" style="font-size:1.0pt;">&nbsp;</font></p>
    </td>
    <td width="89%" valign="top" style="padding:0in 0in 0in 0in;width:89.4%;">
    <p align="left" style="margin:0in 0in .0001pt;text-align:left;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">2007 Non-Employee Directors&#146;
    Stock Option Plan, as amended.</font></p>
    </td>
   </tr>
  </table>
  
  <p align="center" style="margin:0in 0in .0001pt;text-align:center;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>
  
  <p align="center" style="margin:0in 0in .0001pt;text-align:center;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">5</font></p>
  
  <div align="left" style="margin:0in 0in .0001pt;text-align:left;"><hr size="3" width="100%" noshade color="#010101" align="left"></div>
  
  </div>
  <!-- SEQ.=1,FOLIO='5',FILE='C:\JMS\brosent\08-14285-1\task2937504\14285-1-ba-01.htm',USER='brosent',CD='May 13 14:39 2008' -->
  
  
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metadata_filer: {"company-data": {"conformed-name": "GENOPTIX INC", "cik": "0001138412", "assigned-sic": "8071", "irs-number": "330840570", "fiscal-year-end": "1231"}, "filing-values": {"form-type": "8-K", "act": "34", "file-number": "001-33753", "film-number": "08827739"}, "business-address": {"street1": "2110  RUTHERFORD ROAD", "city": "CARLSBAD", "state": "CA", "zip": "92008", "phone": "760-268-6200"}, "mail-address": {"street1": "2110  RUTHERFORD ROAD", "city": "CARLSBAD", "state": "CA", "zip": "92008"}}
text: UNITED
  STATES
  SECURITIES AND EXCHANGE COMMISSION
  Washington,
  DC  20549
  FORM 8-K
  CURRENT
  REPORT
  Pursuant
  to Section 13 or 15(d) of the
  Securities Exchange Act of 1934
  Date of Report
  (Date of earliest event reported):
  May 7, 2008
  GENOPTIX, INC.
  (Exact name of
  registrant as specified in its charter)
  Delaware
  001-33753
  33-0840570
  (State or other
    jurisdiction of
  incorporation)
  (Commission File
    Number)
  (I.R.S. Employer
    Identification
  No.)
  2110
  Rutherford Road
  Carlsbad,
  CA 92008
  (Address of principal
  executive offices and zip code)
  Registrant's
  telephone number, including area code:
  (760) 268-6200
  Check
  the appropriate box below if the Form 8-K filing is intended to
  simultaneously satisfy the filing obligation of the registrant under any of the
  following provisions:
  ¨
  Written communications pursuant to Rule 425
  under the Securities Act (17 CFR 230.425)
  ¨
  Soliciting material pursuant to Rule 14a-12
  under the Exchange Act (17 CFR 240.14a-12)
  ¨
  Pre-commencement communications pursuant to Rule 14d-2(b) under
  the Exchange Act (17 CFR 240.14d-2(b))
  ¨
  Pre-commencement communications pursuant to Rule 13e-4(c) under
  the Exchange Act (17 CFR 240.13e-4(c))
  Item 8.01.              Other
  Events.
  On May 7, 2008, the Board of Directors (the "Board") of Genoptix, Inc.
  ("Genoptix"), following the recommendation of the Compensation Committee of the
  Board, approved certain changes to the Genoptix Non-Employee Director
  Compensation Policy (the "Compensation Policy") and certain related amendments
  to the 2007 Non-employee Directors' Stock Option Plan ("2007 NEDSOP").  The Compensation Committee and the Board
  reviewed the Compensation Policy and the proposed amendments to the 2007 NEDSOP
  in conjunction with information provided by an independent compensation
  consultant. The amended Compensation Policy provides that each member of Board
  will receive an annual fee of $35,000. 
  The amended Compensation Policy also provides that each member of the
  Compensation Committee and Compliance Committee will receive an annual fee of
  $5,000, each member of the Nominating and Corporate Governance Committee will
  receive an annual fee of $2,500, and each member of the Audit Committee will
  receive an annual fee of $7,500, in each case for service as a member of such
  committees.  Additionally, the amended
  Compensation Policy provides that the chair of the Audit Committee will receive
  $15,000 per year for services, and the chair of the Nominating and Corporate
  Governance Committee will receive $5,000 per year for services. Previously, no
  fees were paid for committee membership other than for service as the chair of
  the Audit, Compensation or Compliance committee. No changes were made to the
  cash compensation for the chair of the Board or for committee service payable
  to the chairs of the Compliance Committee and Compensation Committee.
  In addition to the changes to cash compensation, the Board, following
  the recommendation of the Compensation Committee, further amended the Compensation Policy by amending the 2007
  NEDSOP to reduce the initial nonqualified stock option grant each new
  director receives under the 2007 NEDSOP
  in connection with his or her election to the Board from 25,000 shares to 10,000 shares of common stock and approving
  the grant to each new director of a restricted stock unit ("RSU") award for
  5,000 shares of common stock under the 2007 Equity Incentive Plan ("2007 EIP"),
  with such RSU award being made concurrently with the initial stock option grant
  under the 2007 NEDSOP.  The Board,
  following the recommendation of the Compensation Committee, also approved an
  amendment to the 2007 NEDSOP to reduce the
  annual nonqualified stock option grant to be made to each director under the
  2007 NEDSOP from 10,000 shares to 3,750 shares of common stock and
  approved granting, concurrently with such reduced annual grant under the 2007
  NEDSOP, an annual RSU award for 2,500 shares of common stock under the 2007
  EIP, with such annual grants to be made to each director at each Genoptix
  annual stockholders meeting.  The Board
  also approved that the initial grant will be doubled for a newly elected non-employee
  director who at such time is elected to serve as the chair of the Board and the
  annual grant will be doubled for a non-employee director serving as the chair
  of the Board.  Each of the nonqualified
  stock options granted pursuant to the Compensation Plan will be made in
  accordance with the provisions of the 2007 NEDSOP and the RSUs will be made in
  accordance with the provisions of the 2007 EIP. 
  Initial awards vest over three years and annual awards vest over twelve
  months, with monthly vesting from the date of grant for the nonqualified stock
  option portion of each award and quarterly vesting from the date of grant for
  the RSU portion of each award. The initial and annual RSU awards will be
  granted pursuant to a form of RSU Award Agreement for Directors, which will
  contain the same acceleration of vesting provisions upon a change in control as
  those set forth in the nonqualified stock option awards granted under the 2007
  NEDSOP to the non-employee directors.
  The text of the
  Compensation Policy, as amended, is attached as Exhibit 99.1 to
  this Current Report and is incorporated by reference herein.
  The Board, following the recommendation of
  the Compensation Committee, also approved one-time equity awards to existing
  non-employee directors. The Board approved granting each non-employee
  member of the Board a  nonqualified stock
  option to purchase 10,000 shares of common stock and a RSU award for 5,000
  shares of common stock, each to be granted on the date of the Genoptix 2008
  annual stockholders meeting.  The Board
  approved granting the chair of the Board a one-time equity grant equal to twice
  the number of nonqualified stock options and RSUs granted to the other
  non-employee members
  2
  of the Board for his service as the chair of the Board. These equity
  awards will be made pursuant to the 2007 EIP and will vest over three years,
  with the options vesting in equal months installments and the RSUs vesting in
  equal quarterly installments.  The RSU
  portion of these awards will be granted pursuant to the same form of RSU Award
  Agreement for Directors and will contain the same acceleration of vesting
  provisions as the initial and annual nonqualified stock option awards granted
  under the 2007 NEDSOP.  The exercise
  price of the options will be the fair market value of Genoptix common stock on
  the date of the annual stockholder meeting as determined under the 2007
  EIP.   These one-time awards were
  intended to align the equity awards granted to existing non-employee directors
  with the equity awards that will be granted to any new non-employee member of
  the Board.
  Item 9.01.      Financial
  Statements and Exhibits.
  (d) Exhibits
  99.1
  Non-Employee Director Compensation Policy
  , as amended.
  99.2
  2007 Non-Employee Directors' Stock Option
    Plan, as amended.
  3
  SIGNATURE
  Pursuant to the requirements
  of the Securities Exchange Act of 1934, the registrant has duly caused this
  report to be signed on its behalf by the undersigned, thereunto duly
  authorized.
  GENOPTIX, INC.
  Dated:  May 13, 2008
  By:
  /s/
  Christian V. Kuhlen, M.D., Esq.
  Christian V. Kuhlen, M.D., Esq.
  Vice President, General Counsel
  4
  EXHIBIT
  INDEX
  Exhibit
  Number
  Description
  99.1
  Non-Employee Director Compensation Policy
  , as amended.
  99.2
  2007 Non-Employee Directors'
    Stock Option Plan, as amended.
  5