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  <TITLE> Orchestra Therapeutics, Inc. (Form: 8-K) </TITLE>
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  		UNITED STATES<BR>
  	SECURITIES AND EXCHANGE COMMISSION
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  	WASHINGTON, D.C. 20549
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  	FORM 8-K
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  	CURRENT REPORT
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  	Pursuant to Section&nbsp;13 or 15(d) of the Securities Exchange Act of 1934
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  	Date of Report (Date of Earliest Event Reported):
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  	&nbsp;
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  	August 24, 2007
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  	Orchestra Therapeutics, Inc.
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  <BR>__________________________________________<BR>
  	(Exact name of registrant as specified in its charter)
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  	Delaware
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  	000-18006
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  	33-0255679
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  _____________________<BR>
  	(State or other jurisdiction
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  _____________<BR>
  	(Commission
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  ______________<BR>
  	(I.R.S. Employer
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  	of incorporation)
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  	File Number)
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  	Identification No.)
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  	5931 Darwin Court, Carlsbad, California
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  	92008
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  _________________________________<BR>
  	(Address of principal executive offices)
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  ___________<BR>
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  	Registrant&#146;s telephone number, including area code:
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  	(760) 431-7080
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  	Not Applicable
  <BR>______________________________________________<BR>
  	Former name or former address, if changed since last report
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  	&nbsp;
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  <!-- CoverPageRegistrant END --><P><FONT SIZE="2">
  Check the appropriate box below if the Form 8-K filing is intended to
  simultaneously satisfy the filing obligation of the registrant under any
  of the following provisions:</FONT>
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  <P><FONT SIZE="2">
  [&nbsp;&nbsp;]&nbsp;&nbsp;Written communications pursuant to Rule 425 under the Securities Act (17 CFR 230.425)<br>
  [&nbsp;&nbsp;]&nbsp;&nbsp;Soliciting material pursuant to Rule 14a-12 under the Exchange Act (17 CFR 240.14a-12)<br>
  [&nbsp;&nbsp;]&nbsp;&nbsp;Pre-commencement communications pursuant to Rule 14d-2(b) under the Exchange Act (17 CFR 240.14d-2(b))<br>
  [&nbsp;&nbsp;]&nbsp;&nbsp;Pre-commencement communications pursuant to Rule 13e-4(c) under the Exchange Act (17 CFR 240.13e-4(c))<br>
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  	Item 5.02 Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers; Compensatory Arrangements of Certain Officers.
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  On August 24, 2007 Dr. Joseph O'Neill's employment was terminated,without cause, in conjunction with the reorganization of the Company described below. Dr. O'Neill's severance per his 2005 employment agreement is being accrued by the Company and will be paid when the Company's Pennsylvania leasehold manufacturing facility is sold.  In conjunction with this reorganization, Michael Green, Chief Operating Office & Chief Financial Officer of the Company was given the title of President. <br><br>Mr. David Hochman resigned as a director of the Company on August 24, 2007.<br>
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  	Item 8.01 Other Events.
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  On August 24, 2007 the Company laid off almost all of its employees and discontinued its Neurovax multiple sclerosis trial which was being enrolled in Eastern Europe. The Company has hired a broker and is attempting to sell its HIV manufacturing assets and intellectual property.  The proceeds from the sale of these assets will be used to pay its secured and unsecured creditors.  The Company is evaluating strategic options related to its autoimmune technology.
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  	SIGNATURES
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  	Pursuant to the requirements of the Securities Exchange Act of 1934, the
  	registrant has duly caused this report to be signed on its behalf by the
  	undersigned hereunto duly authorized.
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  	Orchestra Therapeutics, Inc.
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  	&nbsp;&nbsp;
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  <I>
  	August 27, 2007
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  	By:
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  <I>
  	Michael Green
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  <I>
  	Name: Michael Green
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  <I>
  	Title: CFO
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metadata_documents: [{"type": "8-K", "sequence": "1", "filename": "htm_22344.htm", "description": "LIVE FILING", "secsgml_size_bytes": 9531}]
metadata_filer: {"company-data": {"conformed-name": "ORCHESTRA THERAPEUTICS, INC.", "cik": "0000817785", "assigned-sic": "2836", "irs-number": "330255679", "state-of-incorporation": "DE", "fiscal-year-end": "1231"}, "filing-values": {"form-type": "8-K", "act": "34", "file-number": "000-18006", "film-number": "071081918"}, "business-address": {"street1": "5931 DARWIN COURT", "city": "CARLSBAD", "state": "CA", "zip": "92008", "phone": "7604317080"}, "mail-address": {"street1": "5931 DARWIN COURT", "city": "CARLSBAD", "state": "CA", "zip": "92008"}, "former-company": {"former-conformed-name": "IMMUNE RESPONSE CORP", "date-changed": "19950911"}}
text: Orchestra Therapeutics, Inc. (Form: 8-K)
  UNITED STATES
  SECURITIES AND EXCHANGE COMMISSION
  WASHINGTON, D.C. 20549
  FORM 8-K
  CURRENT REPORT
  Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934
  Date of Report (Date of Earliest Event Reported):
  August 24, 2007
  Orchestra Therapeutics, Inc.
  __________________________________________
  (Exact name of registrant as specified in its charter)
  Delaware
  000-18006
  33-0255679
  _____________________
  (State or other jurisdiction
  _____________
  (Commission
  ______________
  (I.R.S. Employer
  of incorporation)
  File Number)
  Identification No.)
  5931 Darwin Court, Carlsbad, California
  92008
  _________________________________
  (Address of principal executive offices)
  ___________
  (Zip Code)
  Registrant's telephone number, including area code:
  (760) 431-7080
  Not Applicable
  ______________________________________________
  Former name or former address, if changed since last report
  Check the appropriate box below if the Form 8-K filing is intended to
  simultaneously satisfy the filing obligation of the registrant under any
  of the following provisions:
  [  ]  Written communications pursuant to Rule 425 under the Securities Act (17 CFR 230.425)
  [  ]  Soliciting material pursuant to Rule 14a-12 under the Exchange Act (17 CFR 240.14a-12)
  [  ]  Pre-commencement communications pursuant to Rule 14d-2(b) under the Exchange Act (17 CFR 240.14d-2(b))
  [  ]  Pre-commencement communications pursuant to Rule 13e-4(c) under the Exchange Act (17 CFR 240.13e-4(c))
  Top of the Form
  Item 5.02 Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers; Compensatory Arrangements of Certain Officers.
  On August 24, 2007 Dr. Joseph O'Neill's employment was terminated,without cause, in conjunction with the reorganization of the Company described below. Dr. O'Neill's severance per his 2005 employment agreement is being accrued by the Company and will be paid when the Company's Pennsylvania leasehold manufacturing facility is sold.  In conjunction with this reorganization, Michael Green, Chief Operating Office & Chief Financial Officer of the Company was given the title of President.
  Mr. David Hochman resigned as a director of the Company on August 24, 2007.
  Item 8.01 Other Events.
  On August 24, 2007 the Company laid off almost all of its employees and discontinued its Neurovax multiple sclerosis trial which was being enrolled in Eastern Europe. The Company has hired a broker and is attempting to sell its HIV manufacturing assets and intellectual property.  The proceeds from the sale of these assets will be used to pay its secured and unsecured creditors.  The Company is evaluating strategic options related to its autoimmune technology.
  Top of the Form
  SIGNATURES
  Pursuant to the requirements of the Securities Exchange Act of 1934, the
  	registrant has duly caused this report to be signed on its behalf by the
  	undersigned hereunto duly authorized.
  Orchestra Therapeutics, Inc.
  August 27, 2007
  By:
  Michael Green
  Name: Michael Green
  Title: CFO