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  		UNITED STATES<BR>
  	SECURITIES AND EXCHANGE COMMISSION
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  	WASHINGTON, D.C. 20549
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  	FORM 8-K
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  	CURRENT REPORT
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  	Pursuant to Section&nbsp;13 or 15(d) of the Securities Exchange Act of 1934
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  	Date of Report (Date of Earliest Event Reported):
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  	&nbsp;
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  	April 2, 2007
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  	Altus Pharmaceuticals Inc.
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  <BR>__________________________________________<BR>
  	(Exact name of registrant as specified in its charter)
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  	Delaware
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  	0-51711
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  	04-3573277
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  _____________________<BR>
  	(State or other jurisdiction
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  _____________<BR>
  	(Commission
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  ______________<BR>
  	(I.R.S. Employer
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  	of incorporation)
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  	File Number)
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  	Identification No.)
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  	&nbsp;&nbsp;
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  	125 Sidney Street, Cambridge, Massachusetts
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  	02139
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  _________________________________<BR>
  	(Address of principal executive offices)
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  	&nbsp;
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  ___________<BR>
  	(Zip Code)
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  	Registrant&#146;s telephone number, including area code:
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  	617-299-2900
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  	Not Applicable
  <BR>______________________________________________<BR>
  	Former name or former address, if changed since last report
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  	&nbsp;
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  <!-- CoverPageRegistrant END --><P><FONT SIZE="2">
  Check the appropriate box below if the Form 8-K filing is intended to
  simultaneously satisfy the filing obligation of the registrant under any
  of the following provisions:</FONT>
  </P>
  <P><FONT SIZE="2">
  [&nbsp;&nbsp;]&nbsp;&nbsp;Written communications pursuant to Rule 425 under the Securities Act (17 CFR 230.425)<br>
  [&nbsp;&nbsp;]&nbsp;&nbsp;Soliciting material pursuant to Rule 14a-12 under the Exchange Act (17 CFR 240.14a-12)<br>
  [&nbsp;&nbsp;]&nbsp;&nbsp;Pre-commencement communications pursuant to Rule 14d-2(b) under the Exchange Act (17 CFR 240.14d-2(b))<br>
  [&nbsp;&nbsp;]&nbsp;&nbsp;Pre-commencement communications pursuant to Rule 13e-4(c) under the Exchange Act (17 CFR 240.13e-4(c))<br>
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  	Item 1.01 Entry into a Material Definitive Agreement.
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  On April 2, 2007, Altus Pharmaceuticals Inc. entered into a sublease with Millennium Pharmaceuticals, Inc. ("Millennium") to sublease the entire second and third floors of a building located at 640 Memorial Drive, Cambridge, Massachusetts, containing approximately 72,935 rentable square feet of office and laboratory space.<br><br>Millennium leases the space pursuant to a lease agreement dated August 26, 1993, as amended (the "Prime Lease"), between Millennium and Massachusetts Institute of Technology ("MIT").<br><br>The sublease commences on the later to occur of (i) delivery of the premises and completion of certain work on the premises or (ii) the date on which both parties have executed the sublease and MIT has consented to the sublease, and initially expires on March 31, 2008.  Thereafter, the sublease converts to a tenancy-at-will on a month-to-month basis for a period commencing on April 1, 2008 and expiring on December 31, 2008 (the "At-Will Period").  During the At-Will period, either party may terminate the sublease with 60 days&#x2019; prior written notice.<br><br>The monthly base rent for the sublease is $121,558.33, which includes certain utilities and traditional triple-net operating expenses included as "Additional Rent" under the Prime Lease.<br><br>The foregoing is a summary description of the terms and conditions of the sublease and by its nature is incomplete.  It is qualified in its entirety by reference to the sublease, which is attached hereto as Exhibit 10.1 and the Prime Lease, both of which are also incorporated herein by reference.<br>
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  	Item 9.01 Financial Statements and Exhibits.
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  (d) Exhibits.<br>10.1  Sublease between Altus Pharmaceuticals Inc. and Millennium Pharmaceuticals, Inc dated April 2, 2007 under the Lease Agreement by and between Millennium Pharmaceuticals, Inc. and Massachusetts Institute of Technology, as amended, for 640 Memorial Drive, Cambridge, Massachusetts filed by Millennium Pharmaceuticals, Inc. as Exhibit 10.32 to its Registration Statement on Form S-1 (333-2490)(filed on 3/18/1996), Exhibit 10.57 to its Annual Report on Form 10-K (filed on 3/24/1999), Exhibit 10.6 to its Annual Report on Form 10-K (filed on 2/25/2000), and Exhibit 10.4 to its Annual Report on Form 10-K (filed on 3/15/2001).
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  	SIGNATURES
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  	Pursuant to the requirements of the Securities Exchange Act of 1934, the
  	registrant has duly caused this report to be signed on its behalf by the
  	undersigned hereunto duly authorized.
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  	Altus Pharmaceuticals Inc.
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  	&nbsp;&nbsp;
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  <I>
  	April 5, 2007
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  	By:
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  <I>
  	Jonathan I. Lieber
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  	&nbsp;
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  <I>
  	Name: Jonathan I. Lieber
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  <I>
  	Title: Vice President, Chief Financial Officer and Treasurer
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  	Exhibit&nbsp;Index
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  	Exhibit No.
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  	10.1
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  	&nbsp;
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  Sublease between Altus Pharmaceuticals Inc. and Millennium Pharmaceuticals, Inc dated April 2, 2007 under the Lease Agreement by and between Millennium Pharmaceuticals, Inc. and Massachusetts Institute of Technology, as amended, for 640 Memorial Drive, Cambridge, Massachusetts filed by Millennium Pharmaceuticals, Inc. as Exhibit 10.32 to its Registration Statement on Form S-1 (333-2490)(filed on 3/18/1996), Exhibit 10.57 to its Annual Report on Form 10-K (filed on 3/24/1999), Exhibit 10.6 to its Annual Report on Form 10-K (filed on 2/25/2000), and Exhibit 10.4 to its Annual Report on Form 10-K (filed on 3/15/2001).
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metadata_documents: [{"type": "8-K", "sequence": "1", "filename": "htm_19389.htm", "description": "LIVE FILING", "secsgml_size_bytes": 12487}]
metadata_filer: {"company-data": {"conformed-name": "Altus Pharmaceuticals Inc.", "cik": "0001340744", "assigned-sic": "2836", "irs-number": "043573277", "state-of-incorporation": "DE", "fiscal-year-end": "1231"}, "filing-values": {"form-type": "8-K", "act": "34", "file-number": "000-51711", "film-number": "07750780"}, "business-address": {"street1": "125 SIDNEY STREET", "city": "CAMBRIDGE", "state": "MA", "zip": "02139", "phone": "617-299-2900"}, "mail-address": {"street1": "125 SIDNEY STREET", "city": "CAMBRIDGE", "state": "MA", "zip": "02139"}}
text: Altus Pharmaceuticals Inc. (Form: 8-K)
  UNITED STATES
  SECURITIES AND EXCHANGE COMMISSION
  WASHINGTON, D.C. 20549
  FORM 8-K
  CURRENT REPORT
  Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934
  Date of Report (Date of Earliest Event Reported):
  April 2, 2007
  Altus Pharmaceuticals Inc.
  __________________________________________
  (Exact name of registrant as specified in its charter)
  Delaware
  0-51711
  04-3573277
  _____________________
  (State or other jurisdiction
  _____________
  (Commission
  ______________
  (I.R.S. Employer
  of incorporation)
  File Number)
  Identification No.)
  125 Sidney Street, Cambridge, Massachusetts
  02139
  _________________________________
  (Address of principal executive offices)
  ___________
  (Zip Code)
  Registrant's telephone number, including area code:
  617-299-2900
  Not Applicable
  ______________________________________________
  Former name or former address, if changed since last report
  Check the appropriate box below if the Form 8-K filing is intended to
  simultaneously satisfy the filing obligation of the registrant under any
  of the following provisions:
  [  ]  Written communications pursuant to Rule 425 under the Securities Act (17 CFR 230.425)
  [  ]  Soliciting material pursuant to Rule 14a-12 under the Exchange Act (17 CFR 240.14a-12)
  [  ]  Pre-commencement communications pursuant to Rule 14d-2(b) under the Exchange Act (17 CFR 240.14d-2(b))
  [  ]  Pre-commencement communications pursuant to Rule 13e-4(c) under the Exchange Act (17 CFR 240.13e-4(c))
  Top of the Form
  Item 1.01 Entry into a Material Definitive Agreement.
  On April 2, 2007, Altus Pharmaceuticals Inc. entered into a sublease with Millennium Pharmaceuticals, Inc. ("Millennium") to sublease the entire second and third floors of a building located at 640 Memorial Drive, Cambridge, Massachusetts, containing approximately 72,935 rentable square feet of office and laboratory space.
  Millennium leases the space pursuant to a lease agreement dated August 26, 1993, as amended (the "Prime Lease"), between Millennium and Massachusetts Institute of Technology ("MIT").
  The sublease commences on the later to occur of (i) delivery of the premises and completion of certain work on the premises or (ii) the date on which both parties have executed the sublease and MIT has consented to the sublease, and initially expires on March 31, 2008.  Thereafter, the sublease converts to a tenancy-at-will on a month-to-month basis for a period commencing on April 1, 2008 and expiring on December 31, 2008 (the "At-Will Period").  During the At-Will period, either party may terminate the sublease with 60 days' prior written notice.
  The monthly base rent for the sublease is $121,558.33, which includes certain utilities and traditional triple-net operating expenses included as "Additional Rent" under the Prime Lease.
  The foregoing is a summary description of the terms and conditions of the sublease and by its nature is incomplete.  It is qualified in its entirety by reference to the sublease, which is attached hereto as Exhibit 10.1 and the Prime Lease, both of which are also incorporated herein by reference.
  Item 9.01 Financial Statements and Exhibits.
  (d) Exhibits.
  10.1  Sublease between Altus Pharmaceuticals Inc. and Millennium Pharmaceuticals, Inc dated April 2, 2007 under the Lease Agreement by and between Millennium Pharmaceuticals, Inc. and Massachusetts Institute of Technology, as amended, for 640 Memorial Drive, Cambridge, Massachusetts filed by Millennium Pharmaceuticals, Inc. as Exhibit 10.32 to its Registration Statement on Form S-1 (333-2490)(filed on 3/18/1996), Exhibit 10.57 to its Annual Report on Form 10-K (filed on 3/24/1999), Exhibit 10.6 to its Annual Report on Form 10-K (filed on 2/25/2000), and Exhibit 10.4 to its Annual Report on Form 10-K (filed on 3/15/2001).
  Top of the Form
  SIGNATURES
  Pursuant to the requirements of the Securities Exchange Act of 1934, the
  	registrant has duly caused this report to be signed on its behalf by the
  	undersigned hereunto duly authorized.
  Altus Pharmaceuticals Inc.
  April 5, 2007
  By:
  Jonathan I. Lieber
  Name: Jonathan I. Lieber
  Title: Vice President, Chief Financial Officer and Treasurer
  Top of the Form
  Exhibit Index
  Exhibit No.
  Description
  10.1
  Sublease between Altus Pharmaceuticals Inc. and Millennium Pharmaceuticals, Inc dated April 2, 2007 under the Lease Agreement by and between Millennium Pharmaceuticals, Inc. and Massachusetts Institute of Technology, as amended, for 640 Memorial Drive, Cambridge, Massachusetts filed by Millennium Pharmaceuticals, Inc. as Exhibit 10.32 to its Registration Statement on Form S-1 (333-2490)(filed on 3/18/1996), Exhibit 10.57 to its Annual Report on Form 10-K (filed on 3/24/1999), Exhibit 10.6 to its Annual Report on Form 10-K (filed on 2/25/2000), and Exhibit 10.4 to its Annual Report on Form 10-K (filed on 3/15/2001).