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  <TITLE> Encysive Pharmaceuticals Inc. (Form: 8-K) </TITLE>
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  		UNITED STATES<BR>
  	SECURITIES AND EXCHANGE COMMISSION
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  	WASHINGTON, D.C. 20549
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  	FORM 8-K
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  	CURRENT REPORT
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  	Pursuant to Section&nbsp;13 or 15(d) of the Securities Exchange Act of 1934
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  	Date of Report (Date of Earliest Event Reported):
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  	&nbsp;
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  	April 24, 2007
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  	Encysive Pharmaceuticals Inc.
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  <BR>__________________________________________<BR>
  	(Exact name of registrant as specified in its charter)
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  	Delaware
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  	0-20117
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  	13-3532643
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  _____________________<BR>
  	(State or other jurisdiction
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  _____________<BR>
  	(Commission
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  ______________<BR>
  	(I.R.S. Employer
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  	of incorporation)
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  	File Number)
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  	Identification No.)
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  	4848 Loop Central Drive, Suite 700, Houston, Texas
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  	77081
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  _________________________________<BR>
  	(Address of principal executive offices)
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  ___________<BR>
  	(Zip Code)
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  	Registrant&#146;s telephone number, including area code:
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  	713-796-8822
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  	Not Applicable
  <BR>______________________________________________<BR>
  	Former name or former address, if changed since last report
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  	&nbsp;
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  <!-- CoverPageRegistrant END --><P><FONT SIZE="2">
  Check the appropriate box below if the Form 8-K filing is intended to
  simultaneously satisfy the filing obligation of the registrant under any
  of the following provisions:</FONT>
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  [&nbsp;&nbsp;]&nbsp;&nbsp;Written communications pursuant to Rule 425 under the Securities Act (17 CFR 230.425)<br>
  [&nbsp;&nbsp;]&nbsp;&nbsp;Soliciting material pursuant to Rule 14a-12 under the Exchange Act (17 CFR 240.14a-12)<br>
  [&nbsp;&nbsp;]&nbsp;&nbsp;Pre-commencement communications pursuant to Rule 14d-2(b) under the Exchange Act (17 CFR 240.14d-2(b))<br>
  [&nbsp;&nbsp;]&nbsp;&nbsp;Pre-commencement communications pursuant to Rule 13e-4(c) under the Exchange Act (17 CFR 240.13e-4(c))<br>
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  	Item 8.01 Other Events.
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  On October 19, 2006, Encysive Pharmaceuticals Inc. (the "Company") announced that it had entered into a Common Stock Purchase Agreement (the "Purchase Agreement") with Azimuth Opportunity Ltd. ("Azimuth"), which provides that, upon the terms and subject to the conditions set forth therein, Azimuth is committed to purchase up to $75,000,000 of the Company&#x2019;s common stock, or the number of shares that is one less than twenty percent (20%) of the issued and outstanding shares of the Company&#x2019;s common stock as of October 19, 2006, whichever occurs first, over the 18-month term of the Purchase Agreement.  On April 9, 2007 and April 24, 2007, the Company closed two additional draw down requests under the Purchase Agreement and received additional aggregate gross proceeds of approximately $18,000,000 and net proceeds of approximately $17,775,000 after deducting estimated offering expenses. The Company issued an aggregate of 5,939,745 shares of the Company&#x2019;s common stock to Azimuth from these draw down requests. As of April 24, 2007, the total number of issued and outstanding shares of the Company&#x2019;s common stock following these issuances is 70,158,934 shares.
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  	SIGNATURES
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  	Pursuant to the requirements of the Securities Exchange Act of 1934, the
  	registrant has duly caused this report to be signed on its behalf by the
  	undersigned hereunto duly authorized.
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  	Encysive Pharmaceuticals Inc.
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  	&nbsp;&nbsp;
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  <I>
  	April 24, 2007
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  	By:
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  <I>
  	/s/ Paul S. Manierre
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  	Name: Paul S. Manierre
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  	Title: Vice President, General Counsel and Secretary
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metadata_documents: [{"type": "8-K", "sequence": "1", "filename": "htm_19747.htm", "description": "LIVE FILING", "secsgml_size_bytes": 9434}]
metadata_filer: {"company-data": {"conformed-name": "ENCYSIVE PHARMACEUTICALS INC", "cik": "0000887023", "assigned-sic": "2834", "irs-number": "133532643", "state-of-incorporation": "DE", "fiscal-year-end": "1231"}, "filing-values": {"form-type": "8-K", "act": "34", "file-number": "000-20117", "film-number": "07784904"}, "business-address": {"street1": "4848 LOOP CENTRAL DRIVE", "street2": "SUITE 700", "city": "HOUSTON", "state": "TX", "zip": "77081", "phone": "7137968822"}, "mail-address": {"street1": "4848 LOOP CENTRAL DRIVE", "street2": "SUITE 700", "city": "HOUSTON", "state": "TX", "zip": "77081"}, "former-company": {"former-conformed-name": "TEXAS BIOTECHNOLOGY CORP /DE/", "date-changed": "19930328"}}
text: Encysive Pharmaceuticals Inc. (Form: 8-K)
  UNITED STATES
  SECURITIES AND EXCHANGE COMMISSION
  WASHINGTON, D.C. 20549
  FORM 8-K
  CURRENT REPORT
  Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934
  Date of Report (Date of Earliest Event Reported):
  April 24, 2007
  Encysive Pharmaceuticals Inc.
  __________________________________________
  (Exact name of registrant as specified in its charter)
  Delaware
  0-20117
  13-3532643
  _____________________
  (State or other jurisdiction
  _____________
  (Commission
  ______________
  (I.R.S. Employer
  of incorporation)
  File Number)
  Identification No.)
  4848 Loop Central Drive, Suite 700, Houston, Texas
  77081
  _________________________________
  (Address of principal executive offices)
  ___________
  (Zip Code)
  Registrant's telephone number, including area code:
  713-796-8822
  Not Applicable
  ______________________________________________
  Former name or former address, if changed since last report
  Check the appropriate box below if the Form 8-K filing is intended to
  simultaneously satisfy the filing obligation of the registrant under any
  of the following provisions:
  [  ]  Written communications pursuant to Rule 425 under the Securities Act (17 CFR 230.425)
  [  ]  Soliciting material pursuant to Rule 14a-12 under the Exchange Act (17 CFR 240.14a-12)
  [  ]  Pre-commencement communications pursuant to Rule 14d-2(b) under the Exchange Act (17 CFR 240.14d-2(b))
  [  ]  Pre-commencement communications pursuant to Rule 13e-4(c) under the Exchange Act (17 CFR 240.13e-4(c))
  Top of the Form
  Item 8.01 Other Events.
  On October 19, 2006, Encysive Pharmaceuticals Inc. (the "Company") announced that it had entered into a Common Stock Purchase Agreement (the "Purchase Agreement") with Azimuth Opportunity Ltd. ("Azimuth"), which provides that, upon the terms and subject to the conditions set forth therein, Azimuth is committed to purchase up to $75,000,000 of the Company's common stock, or the number of shares that is one less than twenty percent (20%) of the issued and outstanding shares of the Company's common stock as of October 19, 2006, whichever occurs first, over the 18-month term of the Purchase Agreement.  On April 9, 2007 and April 24, 2007, the Company closed two additional draw down requests under the Purchase Agreement and received additional aggregate gross proceeds of approximately $18,000,000 and net proceeds of approximately $17,775,000 after deducting estimated offering expenses. The Company issued an aggregate of 5,939,745 shares of the Company's common stock to Azimuth from these draw down requests. As of April 24, 2007, the total number of issued and outstanding shares of the Company's common stock following these issuances is 70,158,934 shares.
  Top of the Form
  SIGNATURES
  Pursuant to the requirements of the Securities Exchange Act of 1934, the
  	registrant has duly caused this report to be signed on its behalf by the
  	undersigned hereunto duly authorized.
  Encysive Pharmaceuticals Inc.
  April 24, 2007
  By:
  /s/ Paul S. Manierre
  Name: Paul S. Manierre
  Title: Vice President, General Counsel and Secretary