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  <p style="margin:0in 0in .0001pt;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>
  
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  <p align="center" style="margin:0in 0in .0001pt;text-align:center;"><b><font size="5" face="Times New Roman" style="font-size:18.0pt;font-weight:bold;">UNITED STATES<br>
  SECURITIES AND EXCHANGE COMMISSION<br>
  </font></b><b><font size="2" style="font-size:10.0pt;font-weight:bold;">WASHINGTON,
  D.C. 20549</font></b></p>
  
  <p align="center" style="margin:0in 0in .0001pt;text-align:center;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>
  
  <div align="center" style="margin:0in 0in .0001pt;text-align:center;"><hr size="1" width="25%" noshade color="black" align="center"></div>
  
  <p align="center" style="margin:0in 0in .0001pt;text-align:center;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>
  
  <p align="center" style="margin:0in 0in .0001pt;text-align:center;"><b><font size="5" face="Times New Roman" style="font-size:18.0pt;font-weight:bold;">FORM&nbsp;8-K</font></b></p>
  
  <p align="center" style="margin:0in 0in .0001pt;text-align:center;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>
  
  <p align="center" style="margin:0in 0in .0001pt;text-align:center;"><b><font size="3" face="Times New Roman" style="font-size:12.0pt;font-weight:bold;">CURRENT REPORT<br>
  Pursuant to Section&nbsp;13 or 15(d)&nbsp;of the Securities Exchange Act of
  1934</font></b></p>
  
  <p align="center" style="margin:0in 0in .0001pt;text-align:center;"><b><font size="3" face="Times New Roman" style="font-size:12.0pt;font-weight:bold;">&nbsp;</font></b></p>
  
  <p align="center" style="margin:0in 0in .0001pt;text-align:center;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">Date of Report (Date of earliest event reported):&#160; <b>May&nbsp;14, 2008</b></font></p>
  
  <p style="margin:0in 0in .0001pt;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>
  
  <p align="center" style="margin:0in 0in .0001pt;text-align:center;"><b><font size="5" face="Times New Roman" style="font-size:18.0pt;font-weight:bold;">Sepracor Inc.</font></b></p>
  
  <p align="center" style="margin:0in 0in .0001pt;text-align:center;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">(Exact Name of Registrant as Specified in Charter)</font></p>
  
  <p style="margin:0in 0in .0001pt;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>
  
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    <td width="32%" valign="top" style="padding:0in .7pt 0in .7pt;width:32.0%;">
    <p align="center" style="margin:0in 0in .0001pt;text-align:center;"><b><font size="2" face="Times New Roman" style="font-size:10.0pt;font-weight:bold;">Delaware</font></b></p>
    </td>
    <td width="2%" valign="bottom" style="padding:0in .7pt 0in .7pt;width:2.0%;">
    <p style="margin:0in 0in .0001pt;"><b><font size="2" face="Times New Roman" style="font-size:1.0pt;font-weight:bold;">&nbsp;</font></b></p>
    </td>
    <td width="32%" valign="top" style="padding:0in .7pt 0in .7pt;width:32.0%;">
    <p align="center" style="margin:0in 0in .0001pt;text-align:center;"><b><font size="2" face="Times New Roman" style="font-size:10.0pt;font-weight:bold;">0-19410</font></b></p>
    </td>
    <td width="2%" valign="bottom" style="padding:0in .7pt 0in .7pt;width:2.0%;">
    <p style="margin:0in 0in .0001pt;"><b><font size="2" face="Times New Roman" style="font-size:1.0pt;font-weight:bold;">&nbsp;</font></b></p>
    </td>
    <td width="32%" valign="top" style="padding:0in .7pt 0in .7pt;width:32.0%;">
    <p align="center" style="margin:0in 0in .0001pt;text-align:center;"><b><font size="2" face="Times New Roman" style="font-size:10.0pt;font-weight:bold;">22-2536587</font></b></p>
    </td>
   </tr>
   <tr>
    <td width="32%" valign="top" style="padding:0in .7pt 0in .7pt;width:32.0%;">
    <p align="center" style="margin:0in 0in .0001pt;text-align:center;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">(State or Other Juris-<br>
    diction of Incorporation</font></p>
    </td>
    <td width="2%" valign="bottom" style="padding:0in .7pt 0in .7pt;width:2.0%;">
    <p style="margin:0in 0in .0001pt;"><font size="2" face="Times New Roman" style="font-size:1.0pt;">&nbsp;</font></p>
    </td>
    <td width="32%" valign="top" style="padding:0in .7pt 0in .7pt;width:32.0%;">
    <p align="center" style="margin:0in 0in .0001pt;text-align:center;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">(Commission<br>
    File Number)</font></p>
    </td>
    <td width="2%" valign="bottom" style="padding:0in .7pt 0in .7pt;width:2.0%;">
    <p style="margin:0in 0in .0001pt;"><font size="2" face="Times New Roman" style="font-size:1.0pt;">&nbsp;</font></p>
    </td>
    <td width="32%" valign="top" style="padding:0in .7pt 0in .7pt;width:32.0%;">
    <p align="center" style="margin:0in 0in .0001pt;text-align:center;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">(IRS Employer<br>
    Identification No.)</font></p>
    </td>
   </tr>
  </table>
  
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  <p align="center" style="margin:0in 0in .0001pt;text-align:center;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>
  
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    <td width="49%" valign="top" style="padding:0in .7pt 0in .7pt;width:49.0%;">
    <p align="center" style="margin:0in 0in .0001pt;text-align:center;"><b><font size="2" face="Times New Roman" style="font-size:10.0pt;font-weight:bold;">84 Waterford Drive<br>
    Marlborough, MA</font></b></p>
    </td>
    <td width="2%" valign="bottom" style="padding:0in .7pt 0in .7pt;width:2.0%;">
    <p style="margin:0in 0in .0001pt;"><b><font size="2" face="Times New Roman" style="font-size:1.0pt;font-weight:bold;">&nbsp;</font></b></p>
    </td>
    <td width="49%" valign="bottom" style="padding:0in .7pt 0in .7pt;width:49.0%;">
    <p align="center" style="margin:0in 0in .0001pt;text-align:center;"><b><font size="2" face="Times New Roman" style="font-size:10.0pt;font-weight:bold;">01752</font></b></p>
    </td>
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    <td width="49%" valign="top" style="padding:0in .7pt 0in .7pt;width:49.0%;">
    <p align="center" style="margin:0in 0in .0001pt;text-align:center;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">(Address of Principal
    Executive Offices)</font></p>
    </td>
    <td width="2%" valign="bottom" style="padding:0in .7pt 0in .7pt;width:2.0%;">
    <p style="margin:0in 0in .0001pt;"><font size="2" face="Times New Roman" style="font-size:1.0pt;">&nbsp;</font></p>
    </td>
    <td width="49%" valign="top" style="padding:0in .7pt 0in .7pt;width:49.0%;">
    <p align="center" style="margin:0in 0in .0001pt;text-align:center;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">(Zip Code)</font></p>
    </td>
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  <p align="center" style="margin:0in 0in .0001pt;text-align:center;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>
  
  <p align="center" style="margin:0in 0in .0001pt;text-align:center;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">Registrant&#146;s telephone number, including area
  code:&#160; <b>(508)
  481-6700</b></font></p>
  
  <p style="margin:0in 0in .0001pt;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>
  
  <p align="center" style="margin:0in 0in .0001pt;text-align:center;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">(Former Name or Former Address, if Changed Since Last
  Report)</font></p>
  
  <p align="center" style="margin:0in 0in .0001pt;text-align:center;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>
  
  <p style="margin:0in 0in .0001pt;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; Check the appropriate box below
  if the Form&nbsp;8-K filing is intended to simultaneously satisfy the filing
  obligation of the registrant under any of the following provisions (<i>see</i> General Instruction A.2. below):</font></p>
  
  <p style="margin:0in 0in .0001pt;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>
  
  <div align="center">
  
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    <td width="5%" valign="top" style="padding:0in .7pt 0in .7pt;width:5.0%;">
    <p align="center" style="margin:0in 0in .0001pt;text-align:center;"><font size="2" face="Wingdings" style="font-size:10.0pt;">o</font></p>
    </td>
    <td width="95%" valign="top" style="padding:0in .7pt 0in .7pt;width:95.0%;">
    <p style="margin:0in 0in .0001pt;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">Written communications pursuant to Rule&nbsp;425
    under the Securities Act (17 CFR 230.425)</font></p>
    </td>
   </tr>
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    <td width="5%" valign="top" style="padding:0in .7pt 0in .7pt;width:5.0%;">
    <p align="center" style="margin:0in 0in .0001pt;text-align:center;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>
    </td>
    <td width="95%" valign="top" style="padding:0in .7pt 0in .7pt;width:95.0%;">
    <p style="margin:0in 0in .0001pt;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>
    </td>
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    <td width="5%" valign="top" style="padding:0in .7pt 0in .7pt;width:5.0%;">
    <p align="center" style="margin:0in 0in .0001pt;text-align:center;"><font size="2" face="Wingdings" style="font-size:10.0pt;">o</font></p>
    </td>
    <td width="95%" valign="top" style="padding:0in .7pt 0in .7pt;width:95.0%;">
    <p style="margin:0in 0in .0001pt;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">Soliciting material pursuant to Rule&nbsp;14a-12
    under the Exchange Act (17 CFR 240.14a-12)</font></p>
    </td>
   </tr>
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    <td width="5%" valign="top" style="padding:0in .7pt 0in .7pt;width:5.0%;">
    <p align="center" style="margin:0in 0in .0001pt;text-align:center;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>
    </td>
    <td width="95%" valign="top" style="padding:0in .7pt 0in .7pt;width:95.0%;">
    <p style="margin:0in 0in .0001pt;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>
    </td>
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    <p align="center" style="margin:0in 0in .0001pt;text-align:center;"><font size="2" face="Wingdings" style="font-size:10.0pt;">o</font></p>
    </td>
    <td width="95%" valign="top" style="padding:0in .7pt 0in .7pt;width:95.0%;">
    <p style="margin:0in 0in .0001pt;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">Pre-commencement communications pursuant to
    Rule&nbsp;14d-2(b)&nbsp;under the Exchange Act (17 CFR 240.14d-2(b))</font></p>
    </td>
   </tr>
   <tr>
    <td width="5%" valign="top" style="padding:0in .7pt 0in .7pt;width:5.0%;">
    <p align="center" style="margin:0in 0in .0001pt;text-align:center;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>
    </td>
    <td width="95%" valign="top" style="padding:0in .7pt 0in .7pt;width:95.0%;">
    <p style="margin:0in 0in .0001pt;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>
    </td>
   </tr>
   <tr>
    <td width="5%" valign="top" style="padding:0in .7pt 0in .7pt;width:5.0%;">
    <p align="center" style="margin:0in 0in .0001pt;text-align:center;"><font size="2" face="Wingdings" style="font-size:10.0pt;">o</font></p>
    </td>
    <td width="95%" valign="top" style="padding:0in .7pt 0in .7pt;width:95.0%;">
    <p style="margin:0in 0in .0001pt;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">Pre-commencement communications pursuant to
    Rule&nbsp;13e-4(c)&nbsp;under the Exchange Act (17 CFR 240.13e-4(c))</font></p>
    </td>
   </tr>
  </table>
  
  </div>
  
  <p style="margin:0in 0in .0001pt;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>
  
  <div style="border:none;border-bottom:double windowtext 6.0pt;padding:0in 0in 0in 0in;">
  
  <p style="border:none;margin:0in 0in .0001pt 1.0in;padding:0in;text-autospace:none;text-indent:-1.0in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>
  
  </div>
  
  <p style="margin:0in 0in .0001pt 1.0in;text-autospace:none;text-indent:-1.0in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>
  
  <div style="margin:0in 0in .0001pt;text-autospace:none;"><hr size="3" width="100%" noshade color="#010101" align="left"></div>
  
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  <!-- SEQ.=1,FOLIO='',FILE='C:\JMS\eudelhofen\08-14385-1\task2940367\14385-1-ba.htm',USER='eudelho',CD='May 14 13:28 2008' -->
  
  
  <br clear="all" style="page-break-before:always;">
  
  
  <div style="font-family:Times New Roman;">
  
  <p style="margin:0in 0in .0001pt 1.0in;text-autospace:none;text-indent:-1.0in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>
  
  <p style="margin:0in 0in .0001pt 1.0in;text-autospace:none;text-indent:-1.0in;"><b><font size="2" face="Times New Roman" style="font-size:10.0pt;font-weight:bold;">Item 5.02</font></b><b><font size="1" style="font-size:3.0pt;font-weight:bold;">&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; </font></b><b><font size="2" style="font-size:10.0pt;font-weight:bold;">Departure of Directors or
  Principal Officers; Election of Directors; Appointment of Principal Officers;
  Compensatory Arrangements of Certain Officers</font></b></p>
  
  <p style="margin:0in 0in .0001pt 1.0in;text-autospace:none;text-indent:-1.0in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>
  
  <p style="margin:0in 0in .0001pt;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; <b><i style="font-weight:bold;">Departure
  of Principal Officer and Compensatory Arrangement &#151; David P. Southwell</i></b></font></p>
  
  <p style="margin:0in 0in .0001pt;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>
  
  <p style="margin:0in 0in .0001pt;"><i><font size="2" face="Times New Roman" style="font-size:10.0pt;font-style:italic;">&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; </font></i><font size="2" style="font-size:10.0pt;">On May&nbsp;14, 2008, Sepracor Inc. (the &#147;Company&#148;)
  and David P. Southwell entered into a Severance and Consulting Agreement (the &#147;Consulting
  Agreement&#148;) pursuant to which Mr.&nbsp;Southwell agreed to resign as the
  Company&#146;s Chief Financial Officer on May&nbsp;20, 2008.&#160; Following such resignation date, Mr.&nbsp;Southwell
  will continue to serve as a consultant to the Company through December&nbsp;31,
  2008 to assist in the transition of his work and to provide such other advice
  and assistance on corporate projects as reasonably requested by the Company&#146;s
  Chief Executive Officer.&#160; During this
  consulting period, the Company will pay Mr.&nbsp;Southwell a consulting fee
  based on an annual rate of $530,000, payable in bi-weekly installments.</font></p>
  
  <p style="margin:0in 0in .0001pt;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>
  
  <p style="margin:0in 0in .0001pt;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; The Consulting Agreement also
  provides for the following severance benefits to Mr.&nbsp;Southwell: (a)&nbsp;for
  a period of 24 months following the conclusion of the consulting period
  described above (the &#147;Severance Period), a severance payment equal to $795,000
  per year, payable in bi-weekly installments, (b)&nbsp;continued healthcare
  benefits and (c)&nbsp;continued use of a Company vehicle.&#160; During the Severance Period, Mr.&nbsp;Southwell
  agrees that he will not directly or indirectly compete with the Company&#146;s
  business or solicit or hire Company employees.</font></p>
  
  <p style="margin:0in 0in .0001pt;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>
  
  <p style="margin:0in 0in .0001pt;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; <b><i style="font-weight:bold;">Appointment
  of Principal Officer and Compensatory Arrangement &#151; Robert F. Scumaci</i></b></font></p>
  
  <p style="margin:0in 0in .0001pt;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>
  
  <p style="margin:0in 0in .0001pt;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; On May&nbsp;14, 2008, the
  Company&#146;s Board of Directors appointed Robert F. Scumaci, the Company&#146;s
  Executive Vice President, Corporate Finance, Administration and Technical
  Operations, to the position of Chief Financial Officer, effective May&nbsp;20,
  2008.&#160; On May&nbsp;14, 2008, the Company
  and Mr.&nbsp;Scumaci entered into an employment agreement pursuant to which Mr.&nbsp;Scumaci
  is entitled to (a)&nbsp;a minimum annual base salary of $520,000, (b)&nbsp;a
  minimum annual performance-based bonus target of 50% of his then base salary
  and (c)&nbsp;an automobile allowance or a leased automobile with a retail value
  of up to $60,000. The term of Mr.&nbsp;Scumaci&#146;s employment agreement is five
  years, but may be terminated earlier (a)&nbsp;at the Company&#146;s election for
  cause (as defined in the employment agreement), (b)&nbsp;upon Mr.&nbsp;Scumaci&#146;s
  death or disability, (c)&nbsp;by Mr.&nbsp;Scumaci for good reason (as defined
  in the employment agreement) or (d)&nbsp;by Mr.&nbsp;Scumaci or the Company
  upon 60 days&#146; notice to the other.&#160; Mr.&nbsp;Scumaci&#146;s
  employment agreement also provides that he will not directly or indirectly
  compete with the Company&#146;s business and will not solicit or hire Company
  employees for a period of 12 months following the termination of his
  employment.</font></p>
  
  <p style="margin:0in 0in .0001pt;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>
  
  <p style="margin:0in 0in .0001pt;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; Mr.&nbsp;Scumaci is entitled to
  the following severance payments in the event his employment is terminated by
  the Company without cause or if he terminates his employment for good
  reason:&#160; (a)&nbsp;continued payment of
  his then base salary for 24 months following termination, (b)&nbsp;the pro
  rated portion of the bonus that he would have otherwise received during the
  year that he was terminated, (c)&nbsp;an amount equal to 1.5 times the average
  bonus that he earned during the two years prior to his termination, payable in
  equal installments over a 24 month period, and (d)&nbsp;24 months of continued
  health care benefit coverage.&#160; In all
  other events of termination, he is entitled to accrued salary and bonus
  payments then due to him.</font></p>
  
  <p style="margin:0in 0in .0001pt;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>
  
  <p style="margin:0in 0in .0001pt;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; Mr.&nbsp;Scumaci&#146;s employment
  agreement supersedes all prior agreements relating to the same subject matter,
  other than the Executive Retention Agreement by and between Mr.&nbsp;Scumaci
  and the Company, dated February&nbsp;1, 2002, which has previously been filed
  with the Securities and Exchange Commission.</font></p>
  
  <p style="margin:0in 0in .0001pt;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>
  
  <p style="margin:0in 0in .0001pt;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; <b><i style="font-weight:bold;">Compensatory
  Arrangement &#151; Mark H.N. Corrigan</i></b></font></p>
  
  <p style="margin:0in 0in .0001pt;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>
  
  <p style="margin:0in 0in .0001pt;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; On May&nbsp;14, 2008, the
  Company and Mark H.N. Corrigan entered into an employment agreement pursuant to
  which Dr.&nbsp;Corrigan has agreed to continue to serve as Executive
  Vice-President, Research and Development of the Company and is entitled to (a)&nbsp;a
  minimum annual base salary of $545,000, (b)&nbsp;a minimum annual
  performance-based bonus target of 50% of his then base salary and (c)&nbsp;an
  automobile allowance or a leased automobile with a retail value of up to
  $60,000.&#160; The term of Dr.&nbsp;Corrigan&#146;s
  employment agreement is five years, but may terminated earlier (a)&nbsp;at the
  Company&#146;s election for cause (as defined in the employment agreement), (b)&nbsp;upon
  Dr.&nbsp;Corrigan&#146;s </font></p>
  
  <p align="center" style="margin:0in 0in .0001pt;text-align:center;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>
  
  <p align="center" style="margin:0in 0in .0001pt;text-align:center;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">2</font></p>
  
  <div style="margin:0in 0in .0001pt;"><hr size="3" width="100%" noshade color="#010101" align="left"></div>
  
  </div>
  <!-- SEQ.=1,FOLIO='2',FILE='C:\JMS\eudelhofen\08-14385-1\task2940367\14385-1-ba.htm',USER='eudelho',CD='May 14 13:28 2008' -->
  
  
  <br clear="all" style="page-break-before:always;">
  
  
  <div>
  
  <p align="center" style="margin:0in 0in .0001pt;text-align:center;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>
  
  <p style="margin:0in 0in .0001pt;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">death
  or disability, (c)&nbsp;by Dr.&nbsp;Corrigan for good reason (as defined in the
  employment agreement) or (d)&nbsp;by Dr.&nbsp;Corrigan or the Company upon 60
  days&#146; notice to the other.&#160; Dr.&nbsp;Corrigan&#146;s
  employment agreement also provides that he will not directly or indirectly
  compete with the Company&#146;s business and will not solicit or hire Company
  employees for a period of 12 months following the termination of his
  employment.</font></p>
  
  <p style="margin:0in 0in .0001pt;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>
  
  <p style="margin:0in 0in .0001pt;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; Dr.&nbsp;Corrigan is entitled to
  the following severance payments in the event his employment is terminated by
  the Company without cause or if he terminates his employment for good
  reason:&#160; (a)&nbsp;continued payment of
  his then base salary for 18 months following termination, (b)&nbsp;the pro
  rated portion of the bonus that he would have otherwise received during the
  year that he was terminated, (c)&nbsp;an amount equal to 1.5 times the average
  bonus that he earned during the two years prior to his termination, payable in
  equal installments over a 24 month period, and (d)&nbsp;18 months of continued
  health care benefit coverage.&#160; In all other
  events of termination, he is entitled to accrued salary and bonus payments then
  due to him.</font></p>
  
  <p style="margin:0in 0in .0001pt;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>
  
  <p style="margin:0in 0in .0001pt;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; Dr.&nbsp;Corrigan&#146;s employment
  agreement supersedes all prior agreements relating to the same subject matter,
  other than the Executive Retention Agreement by and between Dr.&nbsp;Corrigan
  and the Company, dated April&nbsp;17, 2003, which has previously been filed
  with the Securities and Exchange Commission.</font></p>
  
  <p align="center" style="margin:0in 0in .0001pt;text-align:center;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>
  
  <p align="center" style="margin:0in 0in .0001pt;text-align:center;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">3</font></p>
  
  <div style="margin:0in 0in .0001pt;"><hr size="3" width="100%" noshade color="#010101" align="left"></div>
  
  </div>
  <!-- SEQ.=1,FOLIO='3',FILE='C:\JMS\eudelhofen\08-14385-1\task2940367\14385-1-ba.htm',USER='eudelho',CD='May 14 13:28 2008' -->
  
  
  <br clear="all" style="page-break-before:always;">
  
  
  <div>
  
  <p align="center" style="margin:0in 0in .0001pt;text-align:center;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>
  
  <p align="center" style="margin:0in 0in .0001pt;text-align:center;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">SIGNATURE</font></p>
  
  <p align="center" style="margin:0in 0in .0001pt;text-align:center;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>
  
  <p style="margin:0in 0in .0001pt;text-indent:.5in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">Pursuant to the requirements of the Securities Exchange Act of 1934,
  the Registrant has duly caused this report to be signed on its behalf by the
  undersigned hereunto duly authorized.</font></p>
  
  <p style="margin:0in 0in .0001pt;text-indent:.5in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>
  
  <p style="margin:0in 0in .0001pt;text-indent:.5in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>
  
  <table border="0" cellspacing="0" cellpadding="0" width="100%" style="border-collapse:collapse;width:100.0%;">
   <tr>
    <td width="50%" valign="top" style="padding:0in .7pt 0in .7pt;width:50.0%;">
    <p style="margin:0in 0in .0001pt;"><font size="2" face="Times New Roman" style="font-size:1.0pt;">&nbsp;</font></p>
    </td>
    <td width="50%" colspan="2" valign="top" style="padding:0in .7pt 0in .7pt;width:50.0%;">
    <p style="margin:0in 0in .0001pt;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">Sepracor Inc.</font></p>
    </td>
   </tr>
   <tr>
    <td width="50%" valign="top" style="padding:0in .7pt 0in .7pt;width:50.0%;">
    <p style="margin:0in 0in .0001pt;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>
    </td>
    <td width="6%" valign="top" style="padding:0in .7pt 0in .7pt;width:6.06%;">
    <p style="margin:0in 0in .0001pt;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>
    </td>
    <td width="43%" valign="top" style="padding:0in .7pt 0in .7pt;width:43.94%;">
    <p style="margin:0in 0in .0001pt;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>
    </td>
   </tr>
   <tr>
    <td width="50%" valign="top" style="padding:0in .7pt 0in .7pt;width:50.0%;">
    <p style="margin:0in 0in .0001pt;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">Date: May&nbsp;15, 2008</font></p>
    </td>
    <td width="6%" valign="top" style="padding:0in .7pt 0in .7pt;width:6.06%;">
    <p style="margin:0in 0in .0001pt;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">By: </font></p>
    </td>
    <td width="43%" valign="top" style="border:none;border-bottom:solid windowtext 1.0pt;padding:0in .7pt 0in .7pt;width:43.94%;">
    <p style="margin:0in 0in .0001pt;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">/s/ Andrew I. Koven</font></p>
    </td>
   </tr>
   <tr>
    <td width="50%" valign="top" style="padding:0in .7pt 0in .7pt;width:50.0%;">
    <p style="margin:0in 0in .0001pt;"><font size="2" face="Times New Roman" style="font-size:1.0pt;">&nbsp;</font></p>
    </td>
    <td width="6%" valign="top" style="padding:0in .7pt 0in .7pt;width:6.06%;">
    <p style="margin:0in 0in .0001pt;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">Name:</font></p>
    </td>
    <td width="43%" valign="top" style="border:none;padding:0in .7pt 0in .7pt;width:43.94%;">
    <p style="margin:0in 0in .0001pt;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">Andrew I. Koven </font></p>
    </td>
   </tr>
   <tr>
    <td width="50%" valign="top" style="padding:0in .7pt 0in .7pt;width:50.0%;">
    <p style="margin:0in 0in .0001pt;"><font size="2" face="Times New Roman" style="font-size:1.0pt;">&nbsp;</font></p>
    </td>
    <td width="6%" valign="top" style="padding:0in .7pt 0in .7pt;width:6.06%;">
    <p style="margin:0in 0in .0001pt;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">Title:</font></p>
    </td>
    <td width="43%" valign="top" style="padding:0in .7pt 0in .7pt;width:43.94%;">
    <p style="margin:0in 0in .0001pt;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">Executive Vice President, General Counsel and<br>
    Corporate Secretary</font></p>
    </td>
   </tr>
   <tr>
    <td width="50%" valign="top" style="padding:0in .7pt 0in .7pt;width:50.0%;">
    <p style="margin:0in 0in .0001pt;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>
    </td>
    <td width="6%" valign="top" style="padding:0in .7pt 0in .7pt;width:6.06%;">
    <p style="margin:0in 0in .0001pt;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>
    </td>
    <td width="43%" valign="top" style="padding:0in .7pt 0in .7pt;width:43.94%;">
    <p style="margin:0in 0in .0001pt;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>
    </td>
   </tr>
  </table>
  
  <p style="margin:0in 0in .0001pt 1.0in;text-indent:-1.0in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>
  
  <p align="center" style="margin:0in 0in .0001pt;text-align:center;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>
  
  <p align="center" style="margin:0in 0in .0001pt;text-align:center;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">4</font></p>
  
  <div style="margin:0in 0in .0001pt;"><hr size="3" width="100%" noshade color="#010101" align="left"></div>
  
  </div>
  <!-- SEQ.=1,FOLIO='4',FILE='C:\JMS\eudelhofen\08-14385-1\task2940367\14385-1-ba.htm',USER='eudelho',CD='May 14 13:28 2008' -->
  
  
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metadata_filer: {"company-data": {"conformed-name": "SEPRACOR INC /DE/", "cik": "0000877357", "assigned-sic": "2834", "irs-number": "222536587", "state-of-incorporation": "DE", "fiscal-year-end": "1231"}, "filing-values": {"form-type": "8-K", "act": "34", "file-number": "000-19410", "film-number": "08834080"}, "business-address": {"street1": "84 WATERFORD DRIVE", "city": "MARLBOROUGH", "state": "MA", "zip": "01757", "phone": "5084816700"}, "mail-address": {"street1": "84 WATERFORD DRIVE", "city": "MARLBOROUGH", "state": "MA", "zip": "01752"}}
text: UNITED STATES
  SECURITIES AND EXCHANGE COMMISSION
  WASHINGTON,
  D.C. 20549
  FORM 8-K
  CURRENT REPORT
  Pursuant to Section 13 or 15(d) of the Securities Exchange Act of
  1934
  Date of Report (Date of earliest event reported):
  May 14, 2008
  Sepracor Inc.
  (Exact Name of Registrant as Specified in Charter)
  Delaware
  0-19410
  22-2536587
  (State or Other Juris-
  diction of Incorporation
  (Commission
  File Number)
  (IRS Employer
  Identification No.)
  84 Waterford Drive
  Marlborough, MA
  01752
  (Address of Principal
    Executive Offices)
  (Zip Code)
  Registrant's telephone number, including area
  code:
  (508)
  481-6700
  (Former Name or Former Address, if Changed Since Last
  Report)
  Check the appropriate box below
  if the Form 8-K filing is intended to simultaneously satisfy the filing
  obligation of the registrant under any of the following provisions (
  see
  General Instruction A.2. below):
  o
  Written communications pursuant to Rule 425
    under the Securities Act (17 CFR 230.425)
  o
  Soliciting material pursuant to Rule 14a-12
    under the Exchange Act (17 CFR 240.14a-12)
  o
  Pre-commencement communications pursuant to
    Rule 14d-2(b) under the Exchange Act (17 CFR 240.14d-2(b))
  o
  Pre-commencement communications pursuant to
    Rule 13e-4(c) under the Exchange Act (17 CFR 240.13e-4(c))
  Item 5.02
  Departure of Directors or
  Principal Officers; Election of Directors; Appointment of Principal Officers;
  Compensatory Arrangements of Certain Officers
  Departure
  of Principal Officer and Compensatory Arrangement — David P. Southwell
  On May 14, 2008, Sepracor Inc. (the "Company")
  and David P. Southwell entered into a Severance and Consulting Agreement (the "Consulting
  Agreement") pursuant to which Mr. Southwell agreed to resign as the
  Company's Chief Financial Officer on May 20, 2008.  Following such resignation date, Mr. Southwell
  will continue to serve as a consultant to the Company through December 31,
  2008 to assist in the transition of his work and to provide such other advice
  and assistance on corporate projects as reasonably requested by the Company's
  Chief Executive Officer.  During this
  consulting period, the Company will pay Mr. Southwell a consulting fee
  based on an annual rate of $530,000, payable in bi-weekly installments.
  The Consulting Agreement also
  provides for the following severance benefits to Mr. Southwell: (a) for
  a period of 24 months following the conclusion of the consulting period
  described above (the "Severance Period), a severance payment equal to $795,000
  per year, payable in bi-weekly installments, (b) continued healthcare
  benefits and (c) continued use of a Company vehicle.  During the Severance Period, Mr. Southwell
  agrees that he will not directly or indirectly compete with the Company's
  business or solicit or hire Company employees.
  Appointment
  of Principal Officer and Compensatory Arrangement — Robert F. Scumaci
  On May 14, 2008, the
  Company's Board of Directors appointed Robert F. Scumaci, the Company's
  Executive Vice President, Corporate Finance, Administration and Technical
  Operations, to the position of Chief Financial Officer, effective May 20,
  2008.  On May 14, 2008, the Company
  and Mr. Scumaci entered into an employment agreement pursuant to which Mr. Scumaci
  is entitled to (a) a minimum annual base salary of $520,000, (b) a
  minimum annual performance-based bonus target of 50% of his then base salary
  and (c) an automobile allowance or a leased automobile with a retail value
  of up to $60,000. The term of Mr. Scumaci's employment agreement is five
  years, but may be terminated earlier (a) at the Company's election for
  cause (as defined in the employment agreement), (b) upon Mr. Scumaci's
  death or disability, (c) by Mr. Scumaci for good reason (as defined
  in the employment agreement) or (d) by Mr. Scumaci or the Company
  upon 60 days' notice to the other.  Mr. Scumaci's
  employment agreement also provides that he will not directly or indirectly
  compete with the Company's business and will not solicit or hire Company
  employees for a period of 12 months following the termination of his
  employment.
  Mr. Scumaci is entitled to
  the following severance payments in the event his employment is terminated by
  the Company without cause or if he terminates his employment for good
  reason:  (a) continued payment of
  his then base salary for 24 months following termination, (b) the pro
  rated portion of the bonus that he would have otherwise received during the
  year that he was terminated, (c) an amount equal to 1.5 times the average
  bonus that he earned during the two years prior to his termination, payable in
  equal installments over a 24 month period, and (d) 24 months of continued
  health care benefit coverage.  In all
  other events of termination, he is entitled to accrued salary and bonus
  payments then due to him.
  Mr. Scumaci's employment
  agreement supersedes all prior agreements relating to the same subject matter,
  other than the Executive Retention Agreement by and between Mr. Scumaci
  and the Company, dated February 1, 2002, which has previously been filed
  with the Securities and Exchange Commission.
  Compensatory
  Arrangement — Mark H.N. Corrigan
  On May 14, 2008, the
  Company and Mark H.N. Corrigan entered into an employment agreement pursuant to
  which Dr. Corrigan has agreed to continue to serve as Executive
  Vice-President, Research and Development of the Company and is entitled to (a) a
  minimum annual base salary of $545,000, (b) a minimum annual
  performance-based bonus target of 50% of his then base salary and (c) an
  automobile allowance or a leased automobile with a retail value of up to
  $60,000.  The term of Dr. Corrigan's
  employment agreement is five years, but may terminated earlier (a) at the
  Company's election for cause (as defined in the employment agreement), (b) upon
  Dr. Corrigan's
  2
  death
  or disability, (c) by Dr. Corrigan for good reason (as defined in the
  employment agreement) or (d) by Dr. Corrigan or the Company upon 60
  days' notice to the other.  Dr. Corrigan's
  employment agreement also provides that he will not directly or indirectly
  compete with the Company's business and will not solicit or hire Company
  employees for a period of 12 months following the termination of his
  employment.
  Dr. Corrigan is entitled to
  the following severance payments in the event his employment is terminated by
  the Company without cause or if he terminates his employment for good
  reason:  (a) continued payment of
  his then base salary for 18 months following termination, (b) the pro
  rated portion of the bonus that he would have otherwise received during the
  year that he was terminated, (c) an amount equal to 1.5 times the average
  bonus that he earned during the two years prior to his termination, payable in
  equal installments over a 24 month period, and (d) 18 months of continued
  health care benefit coverage.  In all other
  events of termination, he is entitled to accrued salary and bonus payments then
  due to him.
  Dr. Corrigan's employment
  agreement supersedes all prior agreements relating to the same subject matter,
  other than the Executive Retention Agreement by and between Dr. Corrigan
  and the Company, dated April 17, 2003, which has previously been filed
  with the Securities and Exchange Commission.
  3
  SIGNATURE
  Pursuant to the requirements of the Securities Exchange Act of 1934,
  the Registrant has duly caused this report to be signed on its behalf by the
  undersigned hereunto duly authorized.
  Sepracor Inc.
  Date: May 15, 2008
  By:
  /s/ Andrew I. Koven
  Name:
  Andrew I. Koven
  Title:
  Executive Vice President, General Counsel and
  Corporate Secretary
  4