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  <TITLE> Illumina, Inc. (Form: 8-K) </TITLE>
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  		UNITED STATES<BR>
  	SECURITIES AND EXCHANGE COMMISSION
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  	WASHINGTON, D.C. 20549
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  	FORM 8-K
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  	CURRENT REPORT
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  	Pursuant to Section&nbsp;13 or 15(d) of the Securities Exchange Act of 1934
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  	Date of Report (Date of Earliest Event Reported):
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  	&nbsp;
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  	March 23, 2006
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  	Illumina, Inc.
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  <BR>__________________________________________<BR>
  	(Exact name of registrant as specified in its charter)
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  	Delaware
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  	000-30361
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  	33-0804655
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  _____________________<BR>
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  _____________<BR>
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  ______________<BR>
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  	of incorporation)
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  	File Number)
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  	Identification No.)
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  	&nbsp;&nbsp;
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  	9885 Towne Centre Drive, San Diego, California
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  	92121-1975
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  _________________________________<BR>
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  ___________<BR>
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  	Registrant&#146;s telephone number, including area code:
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  	(858) 202-4500
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  	Not Applicable
  <BR>______________________________________________<BR>
  	Former name or former address, if changed since last report
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  	&nbsp;
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  <!-- CoverPageRegistrant END --><P><FONT SIZE="2">
  Check the appropriate box below if the Form 8-K filing is intended to
  simultaneously satisfy the filing obligation of the registrant under any
  of the following provisions:</FONT>
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  <P><FONT SIZE="2">
  [&nbsp;&nbsp;]&nbsp;&nbsp;Written communications pursuant to Rule 425 under the Securities Act (17 CFR 230.425)<br>
  [&nbsp;&nbsp;]&nbsp;&nbsp;Soliciting material pursuant to Rule 14a-12 under the Exchange Act (17 CFR 240.14a-12)<br>
  [&nbsp;&nbsp;]&nbsp;&nbsp;Pre-commencement communications pursuant to Rule 14d-2(b) under the Exchange Act (17 CFR 240.14d-2(b))<br>
  [&nbsp;&nbsp;]&nbsp;&nbsp;Pre-commencement communications pursuant to Rule 13e-4(c) under the Exchange Act (17 CFR 240.13e-4(c))<br>
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  	Item 1.01 Entry into a Material Definitive Agreement.
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  On March 23, 2006, Illumina, Inc. entered into a Subscription Agreement for Secured Convertible Debentures with Genizon Biosciences Inc. ("Genizon"), a Canadian company focused on gene discovery.   Pursuant to the agreement, Illumina purchased a secured convertible debenture of Genizon for CDN$3.5 million and certain warrants. Illumina understands Genizon is exclusively using Illumina&#x2019;s Sentrix&#174; HumanHap300 BeadChip along with the Infinium&#x2122; assay to perform whole-genome association studies involving thousands of members of the Quebec Founder Population.  The goal of the studies is to provide unprecedented understanding of the genetic origins and mechanisms of common diseases which may then lead to possible drug targets.  <br><br>The debenture is convertible, automatically upon the occurrence of a "liquidity event," as defined in the debenture, into Class H Preferred Shares of Genizon. The debenture matures two years from issuance and bears interest, payable semiannually, at a rate of 5% per annum for the first year and 12.5% per annum for the second year. Unless the debenture is converted before maturity, 112.5% of the principal amount of the debenture is due upon maturity. Illumina also received warrants to purchase 226,721 shares of Genizon Class H Prefered Shares at an exercise price of $1.5437 per share. Upon the occurrence of certain events, Illumina may be entitled to receive additional shares of Genizon&#x2019;s Class H Preferred Shares. The above description is qualified in its entirety by reference to the forms of Subscription Agreement, Warrant and Secured Convertible Debenture, which Illumina intends to file as an exhibit to its quarterly report on Form 10-Q for the first quarter of 2006.
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  	SIGNATURES
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  	Pursuant to the requirements of the Securities Exchange Act of 1934, the
  	registrant has duly caused this report to be signed on its behalf by the
  	undersigned hereunto duly authorized.
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  	Illumina, Inc.
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  <I>
  	March 29, 2006
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  	By:
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  <I>
  	/s/ Christian O. Henry
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  	Name: Christian O. Henry
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  <I>
  	Title: Vice President and Chief Financial Officer
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metadata_documents: [{"type": "8-K", "sequence": "1", "filename": "htm_11260.htm", "description": "LIVE FILING", "secsgml_size_bytes": 9977}]
metadata_filer: {"company-data": {"conformed-name": "ILLUMINA INC", "cik": "0001110803", "assigned-sic": "3826", "irs-number": "330804655", "state-of-incorporation": "DE", "fiscal-year-end": "0101"}, "filing-values": {"form-type": "8-K", "act": "34", "file-number": "000-30361", "film-number": "06717314"}, "business-address": {"street1": "9885 TOWNE CENTRE DRIVE", "city": "SAN DIEGO", "state": "CA", "zip": "92121", "phone": "8582024500"}, "mail-address": {"street1": "9885 TOWNE CENTRE DRIVE", "city": "SAN DIEGO", "state": "CA", "zip": "92121"}}
text: Illumina, Inc. (Form: 8-K)
  UNITED STATES
  SECURITIES AND EXCHANGE COMMISSION
  WASHINGTON, D.C. 20549
  FORM 8-K
  CURRENT REPORT
  Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934
  Date of Report (Date of Earliest Event Reported):
  March 23, 2006
  Illumina, Inc.
  __________________________________________
  (Exact name of registrant as specified in its charter)
  Delaware
  000-30361
  33-0804655
  _____________________
  (State or other jurisdiction
  _____________
  (Commission
  ______________
  (I.R.S. Employer
  of incorporation)
  File Number)
  Identification No.)
  9885 Towne Centre Drive, San Diego, California
  92121-1975
  _________________________________
  (Address of principal executive offices)
  ___________
  (Zip Code)
  Registrant's telephone number, including area code:
  (858) 202-4500
  Not Applicable
  ______________________________________________
  Former name or former address, if changed since last report
  Check the appropriate box below if the Form 8-K filing is intended to
  simultaneously satisfy the filing obligation of the registrant under any
  of the following provisions:
  [  ]  Written communications pursuant to Rule 425 under the Securities Act (17 CFR 230.425)
  [  ]  Soliciting material pursuant to Rule 14a-12 under the Exchange Act (17 CFR 240.14a-12)
  [  ]  Pre-commencement communications pursuant to Rule 14d-2(b) under the Exchange Act (17 CFR 240.14d-2(b))
  [  ]  Pre-commencement communications pursuant to Rule 13e-4(c) under the Exchange Act (17 CFR 240.13e-4(c))
  Top of the Form
  Item 1.01 Entry into a Material Definitive Agreement.
  On March 23, 2006, Illumina, Inc. entered into a Subscription Agreement for Secured Convertible Debentures with Genizon Biosciences Inc. ("Genizon"), a Canadian company focused on gene discovery.   Pursuant to the agreement, Illumina purchased a secured convertible debenture of Genizon for CDN$3.5 million and certain warrants. Illumina understands Genizon is exclusively using Illumina's Sentrix® HumanHap300 BeadChip along with the Infinium™ assay to perform whole-genome association studies involving thousands of members of the Quebec Founder Population.  The goal of the studies is to provide unprecedented understanding of the genetic origins and mechanisms of common diseases which may then lead to possible drug targets.
  The debenture is convertible, automatically upon the occurrence of a "liquidity event," as defined in the debenture, into Class H Preferred Shares of Genizon. The debenture matures two years from issuance and bears interest, payable semiannually, at a rate of 5% per annum for the first year and 12.5% per annum for the second year. Unless the debenture is converted before maturity, 112.5% of the principal amount of the debenture is due upon maturity. Illumina also received warrants to purchase 226,721 shares of Genizon Class H Prefered Shares at an exercise price of $1.5437 per share. Upon the occurrence of certain events, Illumina may be entitled to receive additional shares of Genizon's Class H Preferred Shares. The above description is qualified in its entirety by reference to the forms of Subscription Agreement, Warrant and Secured Convertible Debenture, which Illumina intends to file as an exhibit to its quarterly report on Form 10-Q for the first quarter of 2006.
  Top of the Form
  SIGNATURES
  Pursuant to the requirements of the Securities Exchange Act of 1934, the
  	registrant has duly caused this report to be signed on its behalf by the
  	undersigned hereunto duly authorized.
  Illumina, Inc.
  March 29, 2006
  By:
  /s/ Christian O. Henry
  Name: Christian O. Henry
  Title: Vice President and Chief Financial Officer