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<P align="center" style="font-size: 14pt"><B>UNITED STATES<BR>
SECURITIES AND EXCHANGE COMMISSION<BR>
<FONT style="font-size: 12pt">Washington, D.C. 20549
</FONT></B>

<P align="center" style="font-size: 18pt"><B>FORM 8-K</B>

<P align="center" style="font-size: 12pt"><B>CURRENT REPORT<BR>
Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934</B>

<P align="center" style="font-size: 10pt"><B>Date of Report (Date of earliest event reported): May 5, 2009 (May 4, 2009)</B>

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<P align="center" style="font-size: 24pt"><B>TRI-ISTHMUS GROUP, INC.<BR></B>
<FONT style="font-size: 10pt">(Exact name of registrant as specified in its charter)
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    <TD width="32%">&nbsp;</TD>
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    <TD style="border-bottom: 1px solid #000000"><B>Delaware</B></TD>
    <TD>&nbsp;</TD>
    <TD style="border-bottom: 1px solid #000000"><B>000-30326</B></TD>
    <TD>&nbsp;</TD>
    <TD style="border-bottom: 1px solid #000000"><B>77-0557617</B></TD>
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<TR valign="top">
    <TD>(State or other Jurisdiction of Incorporation)</TD>
    <TD>&nbsp;</TD>
    <TD>(Commission File Number)</TD>
    <TD>&nbsp;</TD>
    <TD>(IRS Employer Identification No.)</TD>
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    <TD width="49%">&nbsp;</TD>
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    <TD style="border-bottom: 1px solid #000000"><B>9663 Santa Monica Blvd., #959<BR>Beverly Hills, CA <BR></B></TD>
    <TD>&nbsp;</TD>
    <TD style="border-bottom: 1px solid #000000"><B>90210</B></TD>
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    <TD>(Address of Principal Executive Offices)</TD>
    <TD>&nbsp;</TD>
    <TD>(Zip Code)</TD>
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<P align="center" style="font-size: 10pt">Registrant&#146;s telephone number, including area code: <B>(310) 860-2501</B>


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    <TD nowrap>(Former name or former address if changed since last report.)</TD>
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<P align="left" style="font-size: 10pt">Check the appropriate box below if the Form 8-K filing is intended to simultaneously satisfy the filing obligation of the registrant
under any of the following provisions:

<P align="left" style="font-size: 10pt">
<FONT face="Wingdings">&#111;</FONT> Written communications pursuant to Rule 425 under the Securities Act (17 CFR 230.425)<BR><BR>
<FONT face="Wingdings">&#111;</FONT> Soliciting material pursuant to Rule 14a-12 under the Exchange Act (17 CFR 240.14a-12)<BR><BR>
<FONT face="Wingdings">&#111;</FONT> Pre-commencement communications pursuant to Rule 14d-2(b) under the Exchange Act (17 CFR 240.14d-2(b))<BR><BR>
<FONT face="Wingdings">&#111;</FONT> Pre-commencement communications pursuant to Rule 13e-4(c) under the Exchange Act (17 CFR 240.13e-4(c))<BR>


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<P align="center" style="font-size: 10pt; display: none">1
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    <TD width="3%" nowrap align="left"><B>Item&nbsp;3.02:</b></TD>
    <TD width="1%">&nbsp;</TD>
    <TD><B>Unregistered Sales of Equity Securities</B></TD>
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<P align="left" style="font-size: 10pt; text-indent: 4%">On May&nbsp;4, 2009, Tri-Isthmus Group, Inc., a Delaware corporation (the &#147;<U>Registrant</U>&#148;), accepted warrant
exercises in the amount of 405,000 shares (the &#147;<U>Shares</U>&#148;) of its common stock, par value $0.01 per share (the
&#147;<U>Common Stock</U>&#148;), for an aggregate amount of $202,500 from a total of 6 investors, each of whom represented to
the Registrant in writing that he or she or it is an &#147;Accredited Investor,&#148; as that term is defined in Rule 501(a) of
Regulation&nbsp;D, promulgated under the Securities Act of 1933, as amended (the &#147;<U>Securities Act</U>&#148;). The Shares were
issued pursuant to the exercise of warrants (a form of which is attached hereto as Exhibit&nbsp;4.1) issued on March&nbsp;8,
2007; March&nbsp;23, 2007; April&nbsp;17, 2007; and April&nbsp;26, 2007, in connection with a private placement of our Series&nbsp;5-A
Convertible Preferred Stock, par value $0.01 per share, to various investors. The offer and sales of the Shares
pursuant to the warrant exercises were exempt from the registration and prospectus delivery requirements of the
Securities Act, by virtue of Section&nbsp;4(2) and Regulation&nbsp;D promulgated under the Securities Act.


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    <TD width="3%" nowrap align="left"><B>Item&nbsp;9.01.</B></TD>
    <TD width="1%">&nbsp;</TD>
    <TD><B>Financial Statements and Exhibits.</B></TD>
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<P align="left" style="font-size: 10pt; text-indent: 4%">(a)&nbsp;Not applicable<I>.</I>


<P align="left" style="font-size: 10pt; text-indent: 4%">(b)&nbsp;Not applicable<I>.</I>


<P align="left" style="font-size: 10pt; text-indent: 4%">(c)&nbsp;Not applicable<I>.</I>


<P align="left" style="font-size: 10pt; text-indent: 4%">(d)&nbsp;<B>Exhibits.</B>

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    <TD nowrap align="left" style="border-bottom: 1px solid #000000">Exhibit No.</TD>
    <TD>&nbsp;</TD>
    <TD nowrap align="center" style="border-bottom: 1px solid #000000">Description</TD>
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    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">4.1*
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">Form of Warrant (filed as Exhibit&nbsp;4.2 to the Form&nbsp;8-K, filed with
the SEC on September&nbsp;22, 2006).</TD>
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<P align="left" style="font-size: 10pt">*Exhibits marked with an asterisk (*) have been previously filed with the SEC as indicated and are incorporated herein
by reference.




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<P align="center" style="font-size: 10pt; display: none">2
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<P align="center" style="font-size: 10pt"><B>SIGNATURES</B>


<P align="left" style="font-size: 10pt">Pursuant to the requirements of the Securities Exchange Act of 1934, as amended, the Registrant has duly caused this
report to be signed on its behalf by the undersigned hereunto duly authorized.

<P align="left" style="margin-left:48%; font-size: 10pt">TRI-ISTHMUS GROUP, INC.

<P align="left" style="font-size: 10pt">Date: May&nbsp;5, 2009


<P align="left" style="margin-left:48%; font-size: 10pt; margin-top: -11pt">By: <U><B>/</B>s/ Donald C. Parkerson </U><BR>
&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Donald C. Parkerson<BR>
&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Chief Financial Officer


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<P align="center" style="font-size: 10pt; display: none">3
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<P align="center" style="font-size: 10pt"><B>EXHIBITS</B>


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    <TD width="6%">&nbsp;</TD>
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    <TD nowrap align="left" colspan="3" style="border-bottom: 0px solid #000000">Exhibit</TD>
</TR>
<TR style="font-size: 10pt" valign="bottom">
    <TD nowrap align="left" style="border-bottom: 1px solid #000000">Number</TD>
    <TD>&nbsp;</TD>
    <TD nowrap align="center" style="border-bottom: 1px solid #000000">Description</TD>
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    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">4.1*
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">Form of Warrant (filed as Exhibit&nbsp;4.2 to the Form&nbsp;8-K, filed with the
SEC on September&nbsp;22, 2006).</TD>
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<P align="left" style="font-size: 10pt">*Exhibits marked with an asterisk (*) have been previously filed with the SEC as indicated and are incorporated herein
by reference.


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<P align="center" style="font-size: 10pt; display: none">4
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Form 8-K
UNITED STATES
SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 8-K
CURRENT REPORT
Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934
Date of Report (Date of earliest event reported): May 5, 2009 (May 4, 2009)
TRI-ISTHMUS GROUP, INC.
(Exact name of registrant as specified in its charter)
Delaware
000-30326
77-0557617
(State or other Jurisdiction of Incorporation)
(Commission File Number)
(IRS Employer Identification No.)
9663 Santa Monica Blvd., #959
Beverly Hills, CA
90210
(Address of Principal Executive Offices)
(Zip Code)
Registrant's telephone number, including area code:
(310) 860-2501
(Former name or former address if changed since last report.)
Check the appropriate box below if the Form 8-K filing is intended to simultaneously satisfy the filing obligation of the registrant
under any of the following provisions:
o
Written communications pursuant to Rule 425 under the Securities Act (17 CFR 230.425)
o
Soliciting material pursuant to Rule 14a-12 under the Exchange Act (17 CFR 240.14a-12)
o
Pre-commencement communications pursuant to Rule 14d-2(b) under the Exchange Act (17 CFR 240.14d-2(b))
o
Pre-commencement communications pursuant to Rule 13e-4(c) under the Exchange Act (17 CFR 240.13e-4(c))
Item 3.02:
Unregistered Sales of Equity Securities
On May 4, 2009, Tri-Isthmus Group, Inc., a Delaware corporation (the "
Registrant
"), accepted warrant
exercises in the amount of 405,000 shares (the "
Shares
") of its common stock, par value $0.01 per share (the
"
Common Stock
"), for an aggregate amount of $202,500 from a total of 6 investors, each of whom represented to
the Registrant in writing that he or she or it is an "Accredited Investor," as that term is defined in Rule 501(a) of
Regulation D, promulgated under the Securities Act of 1933, as amended (the "
Securities Act
"). The Shares were
issued pursuant to the exercise of warrants (a form of which is attached hereto as Exhibit 4.1) issued on March 8,
2007; March 23, 2007; April 17, 2007; and April 26, 2007, in connection with a private placement of our Series 5-A
Convertible Preferred Stock, par value $0.01 per share, to various investors. The offer and sales of the Shares
pursuant to the warrant exercises were exempt from the registration and prospectus delivery requirements of the
Securities Act, by virtue of Section 4(2) and Regulation D promulgated under the Securities Act.
Item 9.01.
Financial Statements and Exhibits.
(a) Not applicable
.
(b) Not applicable
.
(c) Not applicable
.
(d)
Exhibits.
Exhibit No.
Description
4.1*
Form of Warrant (filed as Exhibit 4.2 to the Form 8-K, filed with
the SEC on September 22, 2006).
*Exhibits marked with an asterisk (*) have been previously filed with the SEC as indicated and are incorporated herein
by reference.
SIGNATURES
Pursuant to the requirements of the Securities Exchange Act of 1934, as amended, the Registrant has duly caused this
report to be signed on its behalf by the undersigned hereunto duly authorized.
TRI-ISTHMUS GROUP, INC.
Date: May 5, 2009
By:
/
s/ Donald C. Parkerson
Donald C. Parkerson
Chief Financial Officer
EXHIBITS
Exhibit
Number
Description
4.1*
Form of Warrant (filed as Exhibit 4.2 to the Form 8-K, filed with the
SEC on September 22, 2006).
*Exhibits marked with an asterisk (*) have been previously filed with the SEC as indicated and are incorporated herein
by reference.