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<TITLE>Filed by Bowne Pure Compliance</TITLE>
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<P align="center" style="font-size: 14pt"><B>UNITED STATES<BR>
SECURITIES AND EXCHANGE COMMISSION<BR>
<FONT style="font-size: 12pt">Washington, D.C. 20549
</FONT></B>

<P align="center" style="font-size: 18pt"><B>FORM 8-K</B>

<P align="center" style="font-size: 12pt"><B>CURRENT REPORT<BR>
Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934</B>

<P align="center" style="font-size: 10pt"><B>Date of Report (Date of earliest event reported): December 6, 2008</B>

<P align="center">

<P align="center" style="font-size: 24pt"><B>SPECTRUM PHARMACEUTICALS, INC.<BR></B>
<FONT style="font-size: 10pt">(Exact name of registrant as specified in its charter)
</FONT>

<TABLE border="0" width="100%" cellspacing="0" cellpadding="0" style="font-size: 10pt; text-align: center">
<TR>
    <TD width="32%">&nbsp;</TD>
    <TD width="1%">&nbsp;</TD>
    <TD width="33%">&nbsp;</TD>
    <TD width="1%">&nbsp;</TD>
    <TD width="32%">&nbsp;</TD>
</TR>
<TR valign="bottom">
    <TD style="border-bottom: 1px solid #000000"><B>Delaware</B></TD>
    <TD>&nbsp;</TD>
    <TD style="border-bottom: 1px solid #000000"><B>000-28782</B></TD>
    <TD>&nbsp;</TD>
    <TD style="border-bottom: 1px solid #000000"><B>93-0979187</B></TD>
</TR>
<TR valign="top">
    <TD>(State or other Jurisdiction of Incorporation)</TD>
    <TD>&nbsp;</TD>
    <TD>(Commission File Number)</TD>
    <TD>&nbsp;</TD>
    <TD>(IRS Employer Identification No.)</TD>
</TR>
</TABLE>

<TABLE border="0" width="100%" cellspacing="0" cellpadding="0" style="font-size: 10pt; text-align: center">
<TR>
    <TD width="49%">&nbsp;</TD>
    <TD width="1%">&nbsp;</TD>
    <TD width="49%">&nbsp;</TD>
</TR>
<TR valign="bottom">
    <TD style="border-bottom: 1px solid #000000"><B>157 Technology Drive, Irvine, California<BR></B></TD>
    <TD>&nbsp;</TD>
    <TD style="border-bottom: 1px solid #000000"><B>92618</B></TD>
</TR>
<TR valign="top">
    <TD>(Address of Principal Executive Offices)</TD>
    <TD>&nbsp;</TD>
    <TD>(Zip Code)</TD>
</TR>
</TABLE>

<P align="center" style="font-size: 10pt">Registrant&#146;s telephone number, including area code: <B>(949) 788-6700</B>


<TABLE border="0" width="30%" cellspacing="0" cellpadding="0" style="font-size: 10pt; text-align: center">
<TR>
    <TD width="100%">&nbsp;</TD>
</TR>
<TR>
    <TD nowrap style="border-bottom: 1px solid #000000"><B>Not Applicable<BR></B></TD>
</TR>
<TR>
    <TD nowrap>(Former name or former address if changed since last report.)</TD>
</TR>
</TABLE>

<P align="left" style="font-size: 10pt">Check the appropriate box below if the Form 8-K filing is intended to simultaneously satisfy the filing obligation of the registrant
under any of the following provisions:

<P align="left" style="font-size: 10pt">
<FONT face="Wingdings">&#111;</FONT> Written communications pursuant to Rule 425 under the Securities Act (17 CFR 230.425)<BR><BR>
<FONT face="Wingdings">&#111;</FONT> Soliciting material pursuant to Rule 14a-12 under the Exchange Act (17 CFR 240.14a-12)<BR><BR>
<FONT face="Wingdings">&#111;</FONT> Pre-commencement communications pursuant to Rule 14d-2(b) under the Exchange Act (17 CFR 240.14d-2(b))<BR><BR>
<FONT face="Wingdings">&#111;</FONT> Pre-commencement communications pursuant to Rule 13e-4(c) under the Exchange Act (17 CFR 240.13e-4(c))<BR>


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<DIV style="width: 100%; border-bottom: 1pt solid black; margin-top: 10pt; font-size: 1pt">&nbsp;</DIV>
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</DIV>

<P align="center" style="font-size: 10pt">&nbsp;

<P align="center" style="font-size: 10pt; display: none">1
</DIV>

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    <TD width="87%">&nbsp;</TD>
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<TR valign="bottom">
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px"><B>Item&nbsp;5.02</B>
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top"><B>Departure of Directors or Certain Officers; Election of Directors;
Appointment of Certain Officers; Compensatory Arrangements of
Certain Officers.</B></TD>
</TR>
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</TABLE>
</DIV>


<P align="justify" style="font-size: 10pt; text-indent: 4%">On December&nbsp;6, 2008, the Compensation Committee of the Board of Directors (the &#147;Committee&#148;) of Spectrum
Pharmaceuticals, Inc. (the &#147;Company&#148;) approved fiscal 2008 bonus payments and 2009 base salaries (effective January&nbsp;1,
2009) for the Company&#146;s named executive officers, as set forth below in the following table: &nbsp;

<DIV align="center">
<TABLE style="font-size: 10pt" cellspacing="0" border="0" cellpadding="0" width="100%">
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    <TD width="65%">&nbsp;</TD>
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    <TD width="1%">&nbsp;</TD>
    <TD width="5%">&nbsp;</TD>
    <TD width="1%">&nbsp;</TD>
    <TD width="10%">&nbsp;</TD>
    <TD width="1%">&nbsp;</TD>
</TR>

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<TR valign="bottom">
    <TD><DIV style="margin-left:10px; text-indent:-10px"><B>Name</B></DIV></TD>
    <TD>&nbsp;</TD>
    <TD colspan="2" align="center"><B>Fiscal&nbsp;2008<BR>Bonus</B></TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD colspan="2" align="center"><B>Fiscal&nbsp;2009<BR>Base&nbsp;Salary</B></TD>
    <TD>&nbsp;</TD>
</TR>
<TR style="font-size: 1px">
    <TD style="border-top: 1px solid #000000"><DIV style="margin-left:10px; text-indent:-10px">&nbsp;</DIV></TD>
    <TD>&nbsp;</TD>
    <TD nowrap colspan="2" align="right" style="border-top: 1px solid #000000">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD nowrap colspan="2" align="right" style="border-top: 1px solid #000000">&nbsp;</TD>
    <TD>&nbsp;</TD>
</TR>


<TR valign="bottom" style="background: #cceeff">
    <TD><DIV style="margin-left:10px; text-indent:-10px">Rajesh Shrotriya, Chairman, Chief
Executive Officer and President</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left">$</TD>
    <TD align="right">600,000</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD align="left">$</TD>
    <TD align="right">600,000</TD>
    <TD>&nbsp;</TD>
</TR>

<TR valign="bottom">
    <TD><DIV style="margin-left:10px; text-indent:-10px">&nbsp;</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left">&nbsp;</TD>
    <TD align="right">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD align="left">&nbsp;</TD>
    <TD align="right">&nbsp;</TD>
    <TD>&nbsp;</TD>
</TR>

<TR valign="bottom">
    <TD><DIV style="margin-left:10px; text-indent:-10px">Shyam Kumaria, Vice President, Finance</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left">$</TD>
    <TD align="right">50,000</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD align="left">$</TD>
    <TD align="right">275,000</TD>
    <TD>&nbsp;</TD>
</TR>
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</TABLE>
</DIV>


<P align="justify" style="font-size: 10pt; text-indent: 4%">In addition, Dr.&nbsp;Shrotriya shall receive a cash bonus payment of $400,000 upon the closing of the of Purchase and
Formation Agreement with Cell Therapeutics, Inc., for the establishment of a 50/50 owned joint venture RIT Oncology,
LLC, whose purpose will be to commercialize and develop Zevalin&#174; (ibritumomab tiuxetan) in the United States.


<P align="justify" style="font-size: 10pt; text-indent: 4%">The Committee provided the following discussion and analysis of its decision regarding executive compensation.


<P align="justify" style="font-size: 10pt; text-indent: 4%">2008 has been a transformational year for the Company. Despite very difficult economic times, the Company has
flourished. With the acquisition of Zevalin, the Company has two marketed proprietary oncology products, has a product
in phase 3 clinical trials, is in the best financial shape in its history, and has a strong management team with an
excellent track record of success. The Company has been able to do so well in 2008 because of the groundwork that has
been laid over the past three or four years. This started with a strategy of acquiring late-stage products,
diversifying the portfolio, building a strong management team, focusing on creating sources of non-diluting funding and
maintaining tight fiscal controls. This strategy was designed and implemented by the Company&#146;s Chief Executive
Officer, Dr.&nbsp;Raj Shrotriya, along with the assistance of his management team, including the Company&#146;s Vice President,
Finance, Shyam Kumaria. It has resulted in the Company having an outstanding year in 2008 while many other biotech
companies are struggling to survive.


<P align="justify" style="font-size: 10pt; text-indent: 4%">The Company accomplished all of its major goals established at the outset of 2008. Some of the important
accomplishments during 2008 included:


<P>
<TABLE width="100%" border="0" cellpadding="0" cellspacing="0" style="font-size: 10pt">

<TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
    <TD width="4%" style="background: transparent">&nbsp;</TD>
    <TD width="3%" nowrap align="left">&#149;</TD>
    <TD width="1%">&nbsp;</TD>
    <TD><DIV style="text-align: justify">generating $62.2&nbsp;million without issuing a single share of stock or warrant;</DIV></TD>
</TR>

</TABLE>


<P>
<TABLE width="100%" border="0" cellpadding="0" cellspacing="0" style="font-size: 10pt">

<TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
    <TD width="4%" style="background: transparent">&nbsp;</TD>
    <TD width="3%" nowrap align="left">&#149;</TD>
    <TD width="1%">&nbsp;</TD>
    <TD><DIV style="text-align: justify">entering into highly profitable development and commercialization alliance for apaziquone (EOquin&#174;) with
Allergan;</DIV></TD>
</TR>

</TABLE>


<P>
<TABLE width="100%" border="0" cellpadding="0" cellspacing="0" style="font-size: 10pt">

<TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
    <TD width="4%" style="background: transparent">&nbsp;</TD>
    <TD width="3%" nowrap align="left">&#149;</TD>
    <TD width="1%">&nbsp;</TD>
    <TD><DIV style="text-align: justify">accomplishing the above two activities without causing any dilution to stockholders and without employing
the services of any bankers, thus saving millions of dollars in fees;</DIV></TD>
</TR>

</TABLE>


<P>
<TABLE width="100%" border="0" cellpadding="0" cellspacing="0" style="font-size: 10pt">

<TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
    <TD width="4%" style="background: transparent">&nbsp;</TD>
    <TD width="3%" nowrap align="left">&#149;</TD>
    <TD width="1%">&nbsp;</TD>
    <TD><DIV style="text-align: justify">receiving approval from the FDA and launching its first proprietary, oncology drug, Fusilev&#153;;</DIV></TD>
</TR>

</TABLE>


<P>
<TABLE width="100%" border="0" cellpadding="0" cellspacing="0" style="font-size: 10pt">

<TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
    <TD width="4%" style="background: transparent">&nbsp;</TD>
    <TD width="3%" nowrap align="left">&#149;</TD>
    <TD width="1%">&nbsp;</TD>
    <TD><DIV style="text-align: justify">filing additional applications with the FDA for additional an formulation and indication for Fusilev&#153;;</DIV></TD>
</TR>

</TABLE>


<P>
<TABLE width="100%" border="0" cellpadding="0" cellspacing="0" style="font-size: 10pt">

<TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
    <TD width="4%" style="background: transparent">&nbsp;</TD>
    <TD width="3%" nowrap align="left">&#149;</TD>
    <TD width="1%">&nbsp;</TD>
    <TD><DIV style="text-align: justify">building a specialty sales force and marketing team with years of oncology sales and marketing experience;</DIV></TD>
</TR>

</TABLE>


<P>
<TABLE width="100%" border="0" cellpadding="0" cellspacing="0" style="font-size: 10pt">

<TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
    <TD width="4%" style="background: transparent">&nbsp;</TD>
    <TD width="3%" nowrap align="left">&#149;</TD>
    <TD width="1%">&nbsp;</TD>
    <TD><DIV style="text-align: justify">strengthening its management team with the addition of key individuals to advance the Company&#146;s strategy;</DIV></TD>
</TR>



</TABLE>
<P align="center" style="font-size: 10pt">&nbsp;

<P align="center" style="font-size: 10pt; display: none">2
</DIV>

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<H5 align="left" style="page-break-before:always">&nbsp;</H5><P>

<DIV style="font-family: 'Times New Roman',Times,serif; margin-left: .25in; width: 7.20in">

<P>
<TABLE width="100%" border="0" cellpadding="0" cellspacing="0" style="font-size: 10pt">

<TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
    <TD width="4%" style="background: transparent">&nbsp;</TD>
    <TD width="3%" nowrap align="left">&#149;</TD>
    <TD width="1%">&nbsp;</TD>
    <TD><DIV style="text-align: justify">acquiring a 50% interest in Zevalin&#174;, another FDA approved, proprietary, oncology drug with 2008 sales of
about $12&nbsp;million; and</DIV></TD>
</TR>

</TABLE>


<P>
<TABLE width="100%" border="0" cellpadding="0" cellspacing="0" style="font-size: 10pt">

<TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
    <TD width="4%" style="background: transparent">&nbsp;</TD>
    <TD width="3%" nowrap align="left">&#149;</TD>
    <TD width="1%">&nbsp;</TD>
    <TD><DIV style="text-align: justify">maintaining tight control over the Company&#146;s cash.</DIV></TD>
</TR>

</TABLE>


<P align="justify" style="font-size: 10pt; text-indent: 4%">The Committee believes that, unfortunately, all of these great accomplishments have not been reflected in the
Company&#146;s current stock price, due in large part to the meltdown
in the financial markets. However, the Committee believes the Company
is well positioned once the financial markets turn around. Therefore, the use of traditional performance standards, such as stock price
appreciation and return on equity, are not appropriate this year in the evaluation of executive officer performance.
Executive officer compensation was based primarily on advancement of the Company&#146;s business objectives, including the
achievement of product development and regulatory milestones, the acquisition of new products, the recruitment and
retention of highly qualified personnel, the maintenance of superior controls over financial resources, and the
initiation and continuation of corporate collaborations, as well as individual contributions and achievement of
individual business objectives by its executive officers.


<P align="justify" style="font-size: 10pt; text-indent: 4%">The Committee made no change to the base salary of Dr.&nbsp;Shrotriya.

<P align="center" style="font-size: 10pt; text-indent: 4%">&nbsp;

<P align="center" style="font-size: 10pt; display: none">3
</DIV>

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<H5 align="left" style="page-break-before:always">&nbsp;</H5><P>

<DIV style="font-family: 'Times New Roman',Times,serif; margin-left: .25in; width: 7.20in">

<P align="center" style="font-size: 10pt"><B>SIGNATURES</B>



<P align="justify" style="font-size: 10pt; text-indent: 3%">Pursuant to the requirements of the Securities Exchange Act of 1934, the registrant has duly caused this report to
be signed on its behalf by the undersigned hereunto duly authorized.


<P align="justify" style="font-size: 10pt">Date: December&nbsp;11, 2008
<BR>
&nbsp;

<DIV align="center">
<TABLE style="font-size: 10pt" cellspacing="0" border="0" cellpadding="0" width="100%">
<!-- Begin Table Head -->
<TR valign="bottom">
    <TD width="54%">&nbsp;</TD>
    <TD width="6%">&nbsp;</TD>
    <TD width="40%">&nbsp;</TD>
</TR>

<!-- End Table Head -->
<!-- Begin Table Body -->
<TR valign="bottom">
    <TD>&nbsp;</TD>

    <TD colspan="2" valign="top" align="left">SPECTRUM PHARMACEUTICALS, INC.<br><br></TD>
</TR>
<TR valign="bottom">
    <TD>&nbsp;</TD>
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">By:
</DIV></TD>
    <TD align="left" valign="top">/s/ Shyam Kumaria</TD>
</TR>
<TR style="font-size: 1px">
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">
&nbsp;</DIV></TD>
    <TD>&nbsp;</TD>
    <TD nowrap align="left" valign="top" style="border-top: 1px solid #000000">&nbsp;</TD>
</TR>
<TR valign="bottom">
    <TD>&nbsp;</TD>
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">Name:
</DIV></TD>
    <TD align="left" valign="top">Shyam Kumaria</TD>
</TR>
<TR valign="bottom">
    <TD>&nbsp;</TD>
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">Title:
</DIV></TD>

    <TD align="left" valign="top">V.P., Finance</TD>
</TR>
<!-- End Table Body -->
</TABLE>
</DIV>

<P align="center" style="font-size: 10pt">&nbsp;

<P align="center" style="font-size: 10pt; display: none">4
</DIV>
</BODY>
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Filed by Bowne Pure Compliance
UNITED STATES
SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 8-K
CURRENT REPORT
Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934
Date of Report (Date of earliest event reported): December 6, 2008
SPECTRUM PHARMACEUTICALS, INC.
(Exact name of registrant as specified in its charter)
Delaware
000-28782
93-0979187
(State or other Jurisdiction of Incorporation)
(Commission File Number)
(IRS Employer Identification No.)
157 Technology Drive, Irvine, California
92618
(Address of Principal Executive Offices)
(Zip Code)
Registrant's telephone number, including area code:
(949) 788-6700
Not Applicable
(Former name or former address if changed since last report.)
Check the appropriate box below if the Form 8-K filing is intended to simultaneously satisfy the filing obligation of the registrant
under any of the following provisions:
o
Written communications pursuant to Rule 425 under the Securities Act (17 CFR 230.425)
o
Soliciting material pursuant to Rule 14a-12 under the Exchange Act (17 CFR 240.14a-12)
o
Pre-commencement communications pursuant to Rule 14d-2(b) under the Exchange Act (17 CFR 240.14d-2(b))
o
Pre-commencement communications pursuant to Rule 13e-4(c) under the Exchange Act (17 CFR 240.13e-4(c))
Item 5.02
Departure of Directors or Certain Officers; Election of Directors;
Appointment of Certain Officers; Compensatory Arrangements of
Certain Officers.
On December 6, 2008, the Compensation Committee of the Board of Directors (the "Committee") of Spectrum
Pharmaceuticals, Inc. (the "Company") approved fiscal 2008 bonus payments and 2009 base salaries (effective January 1,
2009) for the Company's named executive officers, as set forth below in the following table:
Name
Fiscal 2008
Bonus
Fiscal 2009
Base Salary
Rajesh Shrotriya, Chairman, Chief
Executive Officer and President
$
600,000
$
600,000
Shyam Kumaria, Vice President, Finance
$
50,000
$
275,000
In addition, Dr. Shrotriya shall receive a cash bonus payment of $400,000 upon the closing of the of Purchase and
Formation Agreement with Cell Therapeutics, Inc., for the establishment of a 50/50 owned joint venture RIT Oncology,
LLC, whose purpose will be to commercialize and develop Zevalin® (ibritumomab tiuxetan) in the United States.
The Committee provided the following discussion and analysis of its decision regarding executive compensation.
2008 has been a transformational year for the Company. Despite very difficult economic times, the Company has
flourished. With the acquisition of Zevalin, the Company has two marketed proprietary oncology products, has a product
in phase 3 clinical trials, is in the best financial shape in its history, and has a strong management team with an
excellent track record of success. The Company has been able to do so well in 2008 because of the groundwork that has
been laid over the past three or four years. This started with a strategy of acquiring late-stage products,
diversifying the portfolio, building a strong management team, focusing on creating sources of non-diluting funding and
maintaining tight fiscal controls. This strategy was designed and implemented by the Company's Chief Executive
Officer, Dr. Raj Shrotriya, along with the assistance of his management team, including the Company's Vice President,
Finance, Shyam Kumaria. It has resulted in the Company having an outstanding year in 2008 while many other biotech
companies are struggling to survive.
The Company accomplished all of its major goals established at the outset of 2008. Some of the important
accomplishments during 2008 included:
•
generating $62.2 million without issuing a single share of stock or warrant;
•
entering into highly profitable development and commercialization alliance for apaziquone (EOquin®) with
Allergan;
•
accomplishing the above two activities without causing any dilution to stockholders and without employing
the services of any bankers, thus saving millions of dollars in fees;
•
receiving approval from the FDA and launching its first proprietary, oncology drug, Fusilev™;
•
filing additional applications with the FDA for additional an formulation and indication for Fusilev™;
•
building a specialty sales force and marketing team with years of oncology sales and marketing experience;
•
strengthening its management team with the addition of key individuals to advance the Company's strategy;
•
acquiring a 50% interest in Zevalin®, another FDA approved, proprietary, oncology drug with 2008 sales of
about $12 million; and
•
maintaining tight control over the Company's cash.
The Committee believes that, unfortunately, all of these great accomplishments have not been reflected in the
Company's current stock price, due in large part to the meltdown
in the financial markets. However, the Committee believes the Company
is well positioned once the financial markets turn around. Therefore, the use of traditional performance standards, such as stock price
appreciation and return on equity, are not appropriate this year in the evaluation of executive officer performance.
Executive officer compensation was based primarily on advancement of the Company's business objectives, including the
achievement of product development and regulatory milestones, the acquisition of new products, the recruitment and
retention of highly qualified personnel, the maintenance of superior controls over financial resources, and the
initiation and continuation of corporate collaborations, as well as individual contributions and achievement of
individual business objectives by its executive officers.
The Committee made no change to the base salary of Dr. Shrotriya.
SIGNATURES
Pursuant to the requirements of the Securities Exchange Act of 1934, the registrant has duly caused this report to
be signed on its behalf by the undersigned hereunto duly authorized.
Date: December 11, 2008
SPECTRUM PHARMACEUTICALS, INC.
By:
/s/ Shyam Kumaria
Name:
Shyam Kumaria
Title:
V.P., Finance