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<P align="center" style="font-size: 14pt"><B>UNITED STATES<BR>
SECURITIES AND EXCHANGE COMMISSION<BR>
<FONT style="font-size: 12pt">Washington, D.C. 20549
</FONT></B>

<P align="center" style="font-size: 18pt"><B>FORM 8-K</B>

<P align="center" style="font-size: 12pt"><B>CURRENT REPORT<BR>
Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934</B>

<P align="center" style="font-size: 10pt"><B>Date of Report (Date of earliest event reported): DECEMBER 3, 2008</B>

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<P align="center" style="font-size: 24pt"><B>ISOLAGEN, INC.<BR></B>
<FONT style="font-size: 10pt">(Exact name of registrant as specified in its charter)
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    <TD style="border-bottom: 1px solid #000000"><B>DELAWARE</B></TD>
    <TD>&nbsp;</TD>
    <TD style="border-bottom: 1px solid #000000"><B>001-31564</B></TD>
    <TD>&nbsp;</TD>
    <TD style="border-bottom: 1px solid #000000"><B>87-0458888</B></TD>
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<TR valign="top">
    <TD>(State or other Jurisdiction of Incorporation)</TD>
    <TD>&nbsp;</TD>
    <TD>(Commission File Number)</TD>
    <TD>&nbsp;</TD>
    <TD>(IRS Employer Identification No.)</TD>
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    <TD style="border-bottom: 1px solid #000000"><B>405 EAGLEVIEW BLVD., EXTON, PA<BR></B></TD>
    <TD>&nbsp;</TD>
    <TD style="border-bottom: 1px solid #000000"><B>19341</B></TD>
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    <TD>(Address of Principal Executive Offices)</TD>
    <TD>&nbsp;</TD>
    <TD>(Zip Code)</TD>
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<P align="center" style="font-size: 10pt">Registrant&#146;s telephone number, including area code: <B>(484) 713-6000</B>


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    <TD nowrap>(Former name or former address if changed since last report.)</TD>
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<P align="left" style="font-size: 10pt">Check the appropriate box below if the Form 8-K filing is intended to simultaneously satisfy the filing obligation of the registrant
under any of the following provisions:

<P align="left" style="font-size: 10pt">
<FONT face="Wingdings">&#111;</FONT> Written communications pursuant to Rule 425 under the Securities Act (17 CFR 230.425)<BR><BR>
<FONT face="Wingdings">&#111;</FONT> Soliciting material pursuant to Rule 14a-12 under the Exchange Act (17 CFR 240.14a-12)<BR><BR>
<FONT face="Wingdings">&#111;</FONT> Pre-commencement communications pursuant to Rule 14d-2(b) under the Exchange Act (17 CFR 240.14d-2(b))<BR><BR>
<FONT face="Wingdings">&#111;</FONT> Pre-commencement communications pursuant to Rule 13e-4(c) under the Exchange Act (17 CFR 240.13e-4(c))<BR>


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<P align="justify" style="font-size: 10pt"><B>Item&nbsp;8.01 Other Events</B>


<P align="justify" style="font-size: 10pt">Isolagen, Inc. (&#147;Company&#148;) disclosed in its Form 10-Q for the quarter ended September&nbsp;30, 2008 that it had not paid an
interest payment of $1.6&nbsp;million that was due on November&nbsp;3, 2008. No event of default occurred with respect to the
unpaid interest as the Company&#146;s related indenture agreement defines an interest payment default as a failure in the
payment of any interest when it becomes due and payable, and continuance of such default for a period of 30&nbsp;days. The
Company has made the interest payment within the 30&nbsp;day time
period allotted by the indenture, and therefore is not in default
with respect to the indenture.


<P align="center" style="font-size: 10pt"><U><B>SIGNATURE</B></U>



<P align="justify" style="font-size: 10pt; text-indent: 4%">Pursuant to the requirements of the Securities and Exchange Act of 1934, the registrant has duly caused this
report to be signed on its behalf by the undersigned hereunto duly authorized.

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    <TD colspan="3" valign="top" align="left">ISOLAGEN, INC.</TD>
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    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">Date: December&nbsp;3, 2008
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">By:
</TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">/s/ Todd J. Greenspan</TD>
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&nbsp;</DIV></TD>
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&nbsp;</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">Todd J. Greenspan,</TD>
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&nbsp;</DIV></TD>
    <TD>&nbsp;</TD>
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    <TD align="left" valign="top">Chief Financial Officer</TD>
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{"company-data": {"conformed-name": "ISOLAGEN INC", "cik": "0000357097", "assigned-sic": "2834", "irs-number": "870458888", "state-of-incorporation": "DE", "fiscal-year-end": "1231"}, "filing-values": {"form-type": "8-K", "act": "34", "file-number": "001-31564", "film-number": "081228044"}, "business-address": {"street1": "2500 WILCREST", "street2": "5TH FLOOR", "city": "HOUSTON", "state": "TX", "zip": "77042", "phone": "713-780-4754"}, "mail-address": {"street1": "2500 WILCREST", "street2": "5TH FLOOR", "city": "HOUSTON", "state": "TX", "zip": "77042"}, "former-company": [{"former-conformed-name": "AMERICAN FINANCIAL HOLDING INC /DE", "date-changed": "19960330"}, {"former-conformed-name": "AMERICAN FINANCIAL HOLDING INC /CO", "date-changed": "19921008"}, {"former-conformed-name": "VIDTOR COMMUNICATIONS INC", "date-changed": "19920721"}]}
Filed by Bowne Pure Compliance
UNITED STATES
SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 8-K
CURRENT REPORT
Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934
Date of Report (Date of earliest event reported): DECEMBER 3, 2008
ISOLAGEN, INC.
(Exact name of registrant as specified in its charter)
DELAWARE
001-31564
87-0458888
(State or other Jurisdiction of Incorporation)
(Commission File Number)
(IRS Employer Identification No.)
405 EAGLEVIEW BLVD., EXTON, PA
19341
(Address of Principal Executive Offices)
(Zip Code)
Registrant's telephone number, including area code:
(484) 713-6000
NOT APPLICABLE
(Former name or former address if changed since last report.)
Check the appropriate box below if the Form 8-K filing is intended to simultaneously satisfy the filing obligation of the registrant
under any of the following provisions:
o
Written communications pursuant to Rule 425 under the Securities Act (17 CFR 230.425)
o
Soliciting material pursuant to Rule 14a-12 under the Exchange Act (17 CFR 240.14a-12)
o
Pre-commencement communications pursuant to Rule 14d-2(b) under the Exchange Act (17 CFR 240.14d-2(b))
o
Pre-commencement communications pursuant to Rule 13e-4(c) under the Exchange Act (17 CFR 240.13e-4(c))
Item 8.01 Other Events
Isolagen, Inc. ("Company") disclosed in its Form 10-Q for the quarter ended September 30, 2008 that it had not paid an
interest payment of $1.6 million that was due on November 3, 2008. No event of default occurred with respect to the
unpaid interest as the Company's related indenture agreement defines an interest payment default as a failure in the
payment of any interest when it becomes due and payable, and continuance of such default for a period of 30 days. The
Company has made the interest payment within the 30 day time
period allotted by the indenture, and therefore is not in default
with respect to the indenture.
SIGNATURE
Pursuant to the requirements of the Securities and Exchange Act of 1934, the registrant has duly caused this
report to be signed on its behalf by the undersigned hereunto duly authorized.
ISOLAGEN, INC.
Date: December 3, 2008
By:
/s/ Todd J. Greenspan
Todd J. Greenspan,
Chief Financial Officer