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<TITLE>Filed by Bowne Pure Compliance</TITLE>
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<P style="font-size: 14pt" align="center"><B>UNITED STATES<BR>
SECURITIES AND EXCHANGE COMMISSION<BR>
<FONT
style="font-size: 12pt">Washington, D.C. 20549 </FONT></B>

<P style="font-size: 18pt" align="center"><B>FORM 8-K</B>

<P style="font-size: 12pt" align="center"><B>CURRENT REPORT<BR>
Pursuant to Section 13 or 15(d) of the Securities
Exchange Act of 1934</B>

<P style="font-size: 10pt" align="center"><B>Date of Report (Date of earliest event reported): December 18, 2008
(December 12, 2008)</B>



<P style="font-size: 24pt" align="center"><B>TRI-ISTHMUS GROUP, INC.<BR>
</B><FONT style="font-size: 10pt">(Exact name
of registrant as specified in its charter) </FONT>
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 <TR>
  <TD width="32%">&nbsp;</TD>
  <TD width="1%">&nbsp;</TD>
  <TD width="33%">&nbsp;</TD>
  <TD width="1%">&nbsp;</TD>
  <TD width="32%">&nbsp;</TD>
 </TR>
 <TR valign="bottom">
  <TD style="border-bottom: #000000 1px solid"><B>Delaware</B></TD>
  <TD>&nbsp;</TD>
  <TD style="border-bottom: #000000 1px solid"><B>000-30326</B></TD>
  <TD>&nbsp;</TD>
  <TD style="border-bottom: #000000 1px solid"><B>77-0557617</B></TD>
 </TR>
 <TR valign="top">
  <TD>(State or other Jurisdiction of Incorporation)</TD>
  <TD>&nbsp;</TD>
  <TD>(Commission File Number)</TD>
  <TD>&nbsp;</TD>
  <TD>(IRS Employer Identification No.)</TD>
 </TR>

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  <TD width="49%">&nbsp;</TD>
  <TD width="1%">&nbsp;</TD>
  <TD width="49%">&nbsp;</TD>
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  <TD style="border-bottom: #000000 1px solid"><B>9663 Santa Monica Blvd., #959<BR>
Beverly Hills, CA<BR>
</B></TD>
  <TD>&nbsp;</TD>
  <TD style="border-bottom: #000000 1px solid"><B>90210</B></TD>
 </TR>
 <TR valign="top">
  <TD>(Address of Principal Executive Offices)</TD>
  <TD>&nbsp;</TD>
  <TD>(Zip Code)</TD>
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<P style="font-size: 10pt" align="center">Registrant&#8217;s telephone number, including area code: <B>(310)
860-2501</B>
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  <TD style="border-bottom: #000000 1px solid" nowrap><B>&nbsp;</B></TD>
 </TR>
 <TR>
  <TD nowrap>(Former name or former address if changed since last report.)</TD>
 </TR>

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<P style="font-size: 10pt" align="left">Check the appropriate box below if the Form 8-K filing is intended to
simultaneously satisfy the filing obligation of the registrant under any of the following provisions:

<P style="font-size: 10pt" align="left"><FONT face="Wingdings">o</FONT> Written communications pursuant to Rule 425
under the Securities Act (17 CFR 230.425)<BR>
<BR>
<FONT face="Wingdings">o</FONT> Soliciting material pursuant to Rule
14a-12 under the Exchange Act (17 CFR 240.14a-12)<BR>
<BR>
<FONT face="Wingdings">o</FONT> Pre-commencement
communications pursuant to Rule 14d-2(b) under the Exchange Act (17 CFR 240.14d-2(b))<BR>
<BR>
<FONT
face="Wingdings">o</FONT> Pre-commencement communications pursuant to Rule 13e-4(c) under the Exchange Act (17 CFR
240.13e-4(c))<BR>


<P>&nbsp;
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<P style="display: none; font-size: 10pt" align="center">1
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  <TD nowrap align="left" width="5%"><B>Item&nbsp;3.02.</B></TD>
  <TD width="3%">&nbsp;</TD>
  <TD><B> Unregistered Sales of Equity Securities</B></TD>
 </TR>

</TABLE>


<P style="font-size: 10pt; text-indent: 4%" align="left">On December&nbsp;12, 2008, Tri-Isthmus Group, Inc., a Delaware
corporation (the &#8220;<U>Registrant</U>&#8221;), accepted warrant exercises in the amount of 970,300 shares (the
&#8220;<U>Shares</U>&#8221;) of its common stock, par value $0.01 per share (the &#8220;<U>Common Stock</U>&#8221;),
for an aggregate amount of $439,775 from a total of 17 investors, each of whom represented to the Registrant in writing
that he or she or it is an &#8220;Accredited Investor,&#8221; as that term is defined in Rule 501(a) of
Regulation&nbsp;D, promulgated under the Securities Act of 1933, as amended (the &#8220;<U>Securities Act</U>&#8221;).
The Shares were issued pursuant to the exercise of warrants issued: 1) July&nbsp;18, 2005, which warrants were extended
by extension warrants issued July&nbsp;18, 2007, 2) August&nbsp;2, 2005, and 3) September&nbsp;18, 2006. The issuance
and sale of the Shares pursuant to the warrant exercises were exempt from the registration and prospectus delivery
requirements of the Securities Act, by virtue of Section&nbsp;4(2) and Regulation&nbsp;D promulgated under the
Securities Act.

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  <TD nowrap align="left" width="5%"><B>Item&nbsp;9.01.</B></TD>
  <TD width="3%">&nbsp;</TD>
  <TD><B>Financial Statements and Exhibits.</B></TD>
 </TR>

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<P style="font-size: 10pt; text-indent: 4%" align="left">(a)&nbsp;Not applicable.

<P style="font-size: 10pt; text-indent: 4%" align="left">(b)&nbsp;Not applicable.

<P style="font-size: 10pt; text-indent: 4%" align="left">(c)&nbsp;Not applicable.

<P style="font-size: 10pt; text-indent: 4%" align="left">(d)&nbsp;<B>Exhibits.</B>
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  <TD style="border-bottom: #000000 1px solid" nowrap align="left">Exhibit No.</TD>
  <TD>&nbsp;</TD>
  <TD style="border-bottom: #000000 1px solid" nowrap align="center">Description</TD>
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  <TD valign="top"><DIV style="margin-left: 0px; text-indent: 0px">4.1 </DIV></TD>
  <TD>&nbsp;</TD>
  <TD valign="top" align="left">Form of Extension Warrant, dated July&nbsp;18, 2007</TD>
 </TR>
 <TR valign="bottom">
  <TD valign="top"><DIV style="margin-left: 0px; text-indent: 0px">4.2 </DIV></TD>
  <TD>&nbsp;</TD>
  <TD valign="top" align="left">Form of Warrant, incorporated herein by reference to Exhibit&nbsp;4.2 of our
Form&nbsp;8-K, filed with the SEC on July&nbsp;21, 2005</TD>
 </TR>
 <TR valign="bottom">
  <TD valign="top"><DIV style="margin-left: 0px; text-indent: 0px">4.3 </DIV></TD>
  <TD>&nbsp;</TD>
  <TD valign="top" align="left">Form of Warrant, incorporated herein by reference to Exhibit&nbsp;4.2 of our
Form&nbsp;8-K, filed with the SEC on August&nbsp;23, 2005</TD>
 </TR>
 <TR valign="bottom">
  <TD valign="top"><DIV style="margin-left: 0px; text-indent: 0px">4.4 </DIV></TD>
  <TD>&nbsp;</TD>
  <TD valign="top" align="left">Form of Warrant, incorporated herein by reference to Exhibit&nbsp;4.2 of our
Form&nbsp;8-K, filed with the SEC on September&nbsp;22, 2006</TD>
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<P style="font-size: 10pt" align="center"><B>SIGNATURES</B>

<P style="font-size: 10pt" align="left">Pursuant to the requirements of the Securities Exchange Act of 1934, as
amended, the Registrant has duly caused this report to be signed on its behalf by the undersigned hereunto duly
authorized.

<P style="font-size: 10pt; margin-left: 45%" align="left">TRI-ISTHMUS GROUP, INC.

<P style="font-size: 10pt" align="left">Date: December&nbsp;18, 2008

<P style="margin-top: -11pt; font-size: 10pt; margin-left: 45%" align="left">By: <U><B>/</B>s/ Dennis M.
Smith&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</U>
<BR>
Dennis M. Smith <BR>
Chief Financial Officer

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<P style="display: none; font-size: 10pt" align="center">3
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<P style="font-size: 10pt" align="center"><B>EXHIBIT INDEX</B>
<DIV align="center">
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  <TD width="8%">&nbsp;</TD>
  <TD width="3%">&nbsp;</TD>
  <TD width="89%">&nbsp;</TD>
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<TR style="font-size: 10pt" valign="bottom">
  <TD style="border-bottom: #000000 1px solid" nowrap align="left">Exhibit<BR>Number</TD>
  <TD>&nbsp;</TD>
  <TD style="border-bottom: #000000 1px solid" nowrap align="center">Description</TD>
</TR>
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 <TR valign="bottom">
  <TD valign="top">
<DIV style="margin-left: 0px; text-indent: 0px">4.1 </DIV>
</TD>
  <TD>&nbsp;</TD>
  <TD valign="top" align="left">Form of Extension Warrant, dated July&nbsp;18, 2007</TD>
 </TR>
 <TR valign="bottom">
  <TD valign="top">
<DIV style="margin-left: 0px; text-indent: 0px">4.2 </DIV>
</TD>
  <TD>&nbsp;</TD>
  <TD valign="top" align="left">Form of Warrant, incorporated herein by reference to Exhibit&nbsp;4.2 of our
Form&nbsp;8-K, filed with the SEC on July&nbsp;21, 2005</TD>
 </TR>
 <TR valign="bottom">
  <TD valign="top">
<DIV style="margin-left: 0px; text-indent: 0px">4.3 </DIV>
</TD>
  <TD>&nbsp;</TD>
  <TD valign="top" align="left">Form of Warrant, incorporated herein by reference to Exhibit&nbsp;4.2 of our
Form&nbsp;8-K, filed with the SEC on August&nbsp;23, 2005</TD>
 </TR>
 <TR valign="bottom">
  <TD valign="top">
<DIV style="margin-left: 0px; text-indent: 0px">4.4 </DIV>
</TD>
  <TD>&nbsp;</TD>
  <TD valign="top" align="left">Form of Warrant, incorporated herein by reference to Exhibit&nbsp;4.2 of our
Form&nbsp;8-K, filed with the SEC on September&nbsp;22, 2006</TD>
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<P style="display: none; font-size: 10pt" align="center">4
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Filed by Bowne Pure Compliance
UNITED STATES
SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 8-K
CURRENT REPORT
Pursuant to Section 13 or 15(d) of the Securities
Exchange Act of 1934
Date of Report (Date of earliest event reported): December 18, 2008
(December 12, 2008)
TRI-ISTHMUS GROUP, INC.
(Exact name
of registrant as specified in its charter)
Delaware
000-30326
77-0557617
(State or other Jurisdiction of Incorporation)
(Commission File Number)
(IRS Employer Identification No.)
9663 Santa Monica Blvd., #959
Beverly Hills, CA
90210
(Address of Principal Executive Offices)
(Zip Code)
Registrant's telephone number, including area code:
(310)
860-2501
(Former name or former address if changed since last report.)
Check the appropriate box below if the Form 8-K filing is intended to
simultaneously satisfy the filing obligation of the registrant under any of the following provisions:
o
Written communications pursuant to Rule 425
under the Securities Act (17 CFR 230.425)
o
Soliciting material pursuant to Rule
14a-12 under the Exchange Act (17 CFR 240.14a-12)
o
Pre-commencement
communications pursuant to Rule 14d-2(b) under the Exchange Act (17 CFR 240.14d-2(b))
o
Pre-commencement communications pursuant to Rule 13e-4(c) under the Exchange Act (17 CFR
240.13e-4(c))
Item 3.02.
Unregistered Sales of Equity Securities
On December 12, 2008, Tri-Isthmus Group, Inc., a Delaware
corporation (the "
Registrant
"), accepted warrant exercises in the amount of 970,300 shares (the
"
Shares
") of its common stock, par value $0.01 per share (the "
Common Stock
"),
for an aggregate amount of $439,775 from a total of 17 investors, each of whom represented to the Registrant in writing
that he or she or it is an "Accredited Investor," as that term is defined in Rule 501(a) of
Regulation D, promulgated under the Securities Act of 1933, as amended (the "
Securities Act
").
The Shares were issued pursuant to the exercise of warrants issued: 1) July 18, 2005, which warrants were extended
by extension warrants issued July 18, 2007, 2) August 2, 2005, and 3) September 18, 2006. The issuance
and sale of the Shares pursuant to the warrant exercises were exempt from the registration and prospectus delivery
requirements of the Securities Act, by virtue of Section 4(2) and Regulation D promulgated under the
Securities Act.
Item 9.01.
Financial Statements and Exhibits.
(a) Not applicable.
(b) Not applicable.
(c) Not applicable.
(d)
Exhibits.
Exhibit No.
Description
4.1
Form of Extension Warrant, dated July 18, 2007
4.2
Form of Warrant, incorporated herein by reference to Exhibit 4.2 of our
Form 8-K, filed with the SEC on July 21, 2005
4.3
Form of Warrant, incorporated herein by reference to Exhibit 4.2 of our
Form 8-K, filed with the SEC on August 23, 2005
4.4
Form of Warrant, incorporated herein by reference to Exhibit 4.2 of our
Form 8-K, filed with the SEC on September 22, 2006
SIGNATURES
Pursuant to the requirements of the Securities Exchange Act of 1934, as
amended, the Registrant has duly caused this report to be signed on its behalf by the undersigned hereunto duly
authorized.
TRI-ISTHMUS GROUP, INC.
Date: December 18, 2008
By:
/
s/ Dennis M.
Smith
Dennis M. Smith
Chief Financial Officer
EXHIBIT INDEX
Exhibit
Number
Description
4.1
Form of Extension Warrant, dated July 18, 2007
4.2
Form of Warrant, incorporated herein by reference to Exhibit 4.2 of our
Form 8-K, filed with the SEC on July 21, 2005
4.3
Form of Warrant, incorporated herein by reference to Exhibit 4.2 of our
Form 8-K, filed with the SEC on August 23, 2005
4.4
Form of Warrant, incorporated herein by reference to Exhibit 4.2 of our
Form 8-K, filed with the SEC on September 22, 2006