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<P align="center" style="font-size: 14pt"><B>UNITED STATES<BR>
SECURITIES AND EXCHANGE COMMISSION<BR>
<FONT style="font-size: 12pt">Washington, D.C. 20549
</FONT></B>

<P align="center" style="font-size: 18pt"><B>FORM 8-K</B>

<P align="center" style="font-size: 12pt"><B>CURRENT REPORT<BR>
Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934</B>

<P align="center" style="font-size: 10pt"><B>Date of Report (Date of earliest event reported): MARCH 6, 2009</B>

<P align="center">

<P align="center" style="font-size: 24pt"><B>ISOLAGEN, INC.<BR></B>
<FONT style="font-size: 10pt">(Exact name of registrant as specified in its charter)
</FONT>

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<TR>
    <TD width="32%">&nbsp;</TD>
    <TD width="1%">&nbsp;</TD>
    <TD width="33%">&nbsp;</TD>
    <TD width="1%">&nbsp;</TD>
    <TD width="32%">&nbsp;</TD>
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    <TD style="border-bottom: 1px solid #000000"><B>DELAWARE</B></TD>
    <TD>&nbsp;</TD>
    <TD style="border-bottom: 1px solid #000000"><B>001-31564</B></TD>
    <TD>&nbsp;</TD>
    <TD style="border-bottom: 1px solid #000000"><B>87-0458888</B></TD>
</TR>
<TR valign="top">
    <TD>(State or other Jurisdiction of Incorporation)</TD>
    <TD>&nbsp;</TD>
    <TD>(Commission File Number)</TD>
    <TD>&nbsp;</TD>
    <TD>(IRS Employer Identification No.)</TD>
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    <TD width="49%">&nbsp;</TD>
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    <TD width="49%">&nbsp;</TD>
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    <TD style="border-bottom: 1px solid #000000"><B>405 EAGLEVIEW BLVD., EXTON, PA<BR></B></TD>
    <TD>&nbsp;</TD>
    <TD style="border-bottom: 1px solid #000000"><B>19341</B></TD>
</TR>
<TR valign="top">
    <TD>(Address of Principal Executive Offices)</TD>
    <TD>&nbsp;</TD>
    <TD>(Zip Code)</TD>
</TR>
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<P align="center" style="font-size: 10pt">Registrant&#146;s telephone number, including area code: <B>(484) 713-6000</B>


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    <TD nowrap style="border-bottom: 1px solid #000000"><B>NOT APPLICABLE<BR></B></TD>
</TR>
<TR>
    <TD nowrap>(Former name or former address if changed since last report.)</TD>
</TR>
</TABLE>

<P align="left" style="font-size: 10pt">Check the appropriate box below if the Form 8-K filing is intended to simultaneously satisfy the filing obligation of the registrant
under any of the following provisions:

<P align="left" style="font-size: 10pt">
<FONT face="Wingdings">&#111;</FONT> Written communications pursuant to Rule 425 under the Securities Act (17 CFR 230.425)<BR><BR>
<FONT face="Wingdings">&#111;</FONT> Soliciting material pursuant to Rule 14a-12 under the Exchange Act (17 CFR 240.14a-12)<BR><BR>
<FONT face="Wingdings">&#111;</FONT> Pre-commencement communications pursuant to Rule 14d-2(b) under the Exchange Act (17 CFR 240.14d-2(b))<BR><BR>
<FONT face="Wingdings">&#111;</FONT> Pre-commencement communications pursuant to Rule 13e-4(c) under the Exchange Act (17 CFR 240.13e-4(c))<BR>


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<P align="justify" style="font-size: 10pt"><B>Item&nbsp;8.01 Other Events</B>


<P align="justify" style="font-size: 10pt; text-indent: 4%">Isolagen, Inc. (&#147;Company&#148;) has previously disclosed in its periodic filings with the Securities and Exchange
Commission (the &#147;SEC&#148;) (most recently in the Company&#146;s Quarterly Report on Form 10-Q filed with the SEC on November&nbsp;6,
2008) that it has reached an agreement to settle its securities class action lawsuit and its two derivative actions
against the Company and certain of its current and former officers and directors.


<P align="justify" style="font-size: 10pt; text-indent: 4%">On March&nbsp;6, 2009, the United States District Court for the Eastern District of Pennsylvania issued an order
granting preliminary approval of the settlement of the derivative actions and requiring, among other things, that
notice of the settlement be published as an exhibit to an 8-K filing with the SEC, which is attached hereto as
Exhibit&nbsp;99.1. The notice contains important information about the rights of stockholders in the proposed settlement.

&nbsp;

<P align="justify" style="font-size: 10pt; text-indent: 4%">The settlement is subject to a final determination by the United States District Court for the Eastern District of
Pennsylvania as to, among other things, the fairness, reasonableness and adequacy of the settlement. On May&nbsp;12, 2009,
at 4:00 p.m., a fairness hearing will be held before the Honorable Ronald L. Buckwalter, at the United States District
Court for the Eastern District of Pennsylvania, 601 Market Street, Courtroom 14-A, Philadelphia, Pennsylvania 19106, to
determine: (1)&nbsp;whether the terms of the settlement should be approved as fair, reasonable and adequate, including the
fee and expense award; and (2)&nbsp;whether the derivative actions should be dismissed with prejudice as to the released
persons.


<P align="justify" style="font-size: 10pt"><B>Item&nbsp;9.01 Financial Statements and Exhibits.</B>


<P align="justify" style="font-size: 10pt; text-indent: 4%">(d)&nbsp;Exhibits.&nbsp; The following materials are filed as exhibits to this Current Report on Form&nbsp;8-K:

&nbsp;
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    <TD nowrap align="left"><B>Exhibit</B></TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
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    <TD nowrap align="left" style="border-bottom: 1px solid #000000"><B>Number</B></TD>
    <TD>&nbsp;</TD>
    <TD nowrap align="center" style="border-bottom: 1px solid #000000"><B>Description</B></TD>
</TR>

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<TR valign="bottom">
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">99.1
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">Notice of Pendency of Derivative Actions and Proposed Settlement and Settlement Fairness Hearing</TD>
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<P align="center" style="font-size: 10pt"><U><B>SIGNATURE</B></U>



<P align="justify" style="font-size: 10pt; text-indent: 4%">Pursuant to the requirements of the Securities and Exchange Act of 1934, the registrant has duly caused this
report to be signed on its behalf by the undersigned hereunto duly authorized.

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    <TD>&nbsp;</TD>
    <TD nowrap align="left" colspan="3"><B>ISOLAGEN, INC.</B></TD>
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<TR valign="bottom">
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top"></TD>
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    <TD align="left" valign="top"></TD>
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<TR valign="bottom">
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">Date: March&nbsp;16, 2009
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">By:
</TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">/s/ Todd J. Greenspan</TD>
</TR>
<TR style="font-size: 1px">
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">
&nbsp;</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">&nbsp;</TD>
    <TD nowrap colspan="2" align="left" valign="top" style="border-top: 1px solid #000000">&nbsp;</TD>
</TR>
<TR valign="bottom">
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">
&nbsp;</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">Todd J. Greenspan,</TD>
</TR>
<TR valign="bottom">
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">
&nbsp;</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">Chief Financial Officer</TD>
</TR>
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<P align="center" style="font-size: 10pt; display: none">2




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8-K
UNITED STATES
SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 8-K
CURRENT REPORT
Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934
Date of Report (Date of earliest event reported): MARCH 6, 2009
ISOLAGEN, INC.
(Exact name of registrant as specified in its charter)
DELAWARE
001-31564
87-0458888
(State or other Jurisdiction of Incorporation)
(Commission File Number)
(IRS Employer Identification No.)
405 EAGLEVIEW BLVD., EXTON, PA
19341
(Address of Principal Executive Offices)
(Zip Code)
Registrant's telephone number, including area code:
(484) 713-6000
NOT APPLICABLE
(Former name or former address if changed since last report.)
Check the appropriate box below if the Form 8-K filing is intended to simultaneously satisfy the filing obligation of the registrant
under any of the following provisions:
o
Written communications pursuant to Rule 425 under the Securities Act (17 CFR 230.425)
o
Soliciting material pursuant to Rule 14a-12 under the Exchange Act (17 CFR 240.14a-12)
o
Pre-commencement communications pursuant to Rule 14d-2(b) under the Exchange Act (17 CFR 240.14d-2(b))
o
Pre-commencement communications pursuant to Rule 13e-4(c) under the Exchange Act (17 CFR 240.13e-4(c))
Item 8.01 Other Events
Isolagen, Inc. ("Company") has previously disclosed in its periodic filings with the Securities and Exchange
Commission (the "SEC") (most recently in the Company's Quarterly Report on Form 10-Q filed with the SEC on November 6,
2008) that it has reached an agreement to settle its securities class action lawsuit and its two derivative actions
against the Company and certain of its current and former officers and directors.
On March 6, 2009, the United States District Court for the Eastern District of Pennsylvania issued an order
granting preliminary approval of the settlement of the derivative actions and requiring, among other things, that
notice of the settlement be published as an exhibit to an 8-K filing with the SEC, which is attached hereto as
Exhibit 99.1. The notice contains important information about the rights of stockholders in the proposed settlement.
The settlement is subject to a final determination by the United States District Court for the Eastern District of
Pennsylvania as to, among other things, the fairness, reasonableness and adequacy of the settlement. On May 12, 2009,
at 4:00 p.m., a fairness hearing will be held before the Honorable Ronald L. Buckwalter, at the United States District
Court for the Eastern District of Pennsylvania, 601 Market Street, Courtroom 14-A, Philadelphia, Pennsylvania 19106, to
determine: (1) whether the terms of the settlement should be approved as fair, reasonable and adequate, including the
fee and expense award; and (2) whether the derivative actions should be dismissed with prejudice as to the released
persons.
Item 9.01 Financial Statements and Exhibits.
(d) Exhibits.  The following materials are filed as exhibits to this Current Report on Form 8-K:
Exhibit
Number
Description
99.1
Notice of Pendency of Derivative Actions and Proposed Settlement and Settlement Fairness Hearing
SIGNATURE
Pursuant to the requirements of the Securities and Exchange Act of 1934, the registrant has duly caused this
report to be signed on its behalf by the undersigned hereunto duly authorized.
ISOLAGEN, INC.
Date: March 16, 2009
By:
/s/ Todd J. Greenspan
Todd J. Greenspan,
Chief Financial Officer