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<P align="center" style="font-size: 14pt"><B>UNITED STATES<BR>
SECURITIES AND EXCHANGE COMMISSION<BR>
<FONT style="font-size: 12pt">Washington, D.C. 20549
</FONT></B>

<P align="center" style="font-size: 18pt"><B>FORM 8-K</B>

<P align="center" style="font-size: 12pt"><B>CURRENT REPORT<BR>
Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934</B>

<P align="center" style="font-size: 10pt"><B>Date of Report (Date of earliest event reported): October 21, 2008</B>

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<P align="center" style="font-size: 24pt"><B>Middlefield Banc Corp.<BR></B>
<FONT style="font-size: 10pt">(Exact name of registrant as specified in its charter)
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    <TD style="border-bottom: 1px solid #000000"><B>Ohio</B></TD>
    <TD>&nbsp;</TD>
    <TD style="border-bottom: 1px solid #000000"><B>000-32561</B></TD>
    <TD>&nbsp;</TD>
    <TD style="border-bottom: 1px solid #000000"><B>34-1585111</B></TD>
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    <TD>(State or other Jurisdiction of Incorporation)</TD>
    <TD>&nbsp;</TD>
    <TD>(Commission File Number)</TD>
    <TD>&nbsp;</TD>
    <TD>(IRS Employer Identification No.)</TD>
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    <TD style="border-bottom: 1px solid #000000"><B>15985 East High Street<BR>Middlefield, Ohio<BR></B></TD>
    <TD>&nbsp;</TD>
    <TD style="border-bottom: 1px solid #000000"><B>44062</B></TD>
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    <TD>(Address of Principal Executive Offices)</TD>
    <TD>&nbsp;</TD>
    <TD>(Zip Code)</TD>
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<P align="center" style="font-size: 10pt">Registrant&#146;s telephone number, including area code: <B>(440) 632-1666</B>


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    <TD nowrap style="border-bottom: 1px solid #000000"><B>(not applicable)<BR></B></TD>
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    <TD nowrap>(Former name or former address if changed since last report.)</TD>
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<P align="left" style="font-size: 10pt">Check the appropriate box below if the Form 8-K filing is intended to simultaneously satisfy the filing obligation of the registrant
under any of the following provisions:

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<FONT face="Wingdings">&#111;</FONT> Written communications pursuant to Rule 425 under the Securities Act (17 CFR 230.425)<BR><BR>
<FONT face="Wingdings">&#111;</FONT> Soliciting material pursuant to Rule 14a-12 under the Exchange Act (17 CFR 240.14a-12)<BR><BR>
<FONT face="Wingdings">&#111;</FONT> Pre-commencement communications pursuant to Rule 14d-2(b) under the Exchange Act (17 CFR 240.14d-2(b))<BR><BR>
<FONT face="Wingdings">&#111;</FONT> Pre-commencement communications pursuant to Rule 13e-4(c) under the Exchange Act (17 CFR 240.13e-4(c))<BR>


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<P align="left" style="font-size: 10pt">ITEM 2.02 RESULTS OF OPERATIONS AND FINANCIAL CONDITION


<P align="left" style="font-size: 10pt; text-indent: 4%">The following information is furnished under Item&nbsp;2.02. On October&nbsp;21, 2008, Middlefield Banc Corp. issued a
press release announcing financial results for the third quarter and nine month period ended September&nbsp;30, 2008. A
copy of the press release is attached hereto as Exhibit&nbsp;99 and is incorporated herein by this reference.


<P align="left" style="font-size: 10pt; text-indent: 4%">The information contained or incorporated by reference in this current report on Form 8-K may contain
forward-looking statements, including certain plans, expectations, goals, and projections, which are subject to
numerous assumptions, risks, and uncertainties. Actual results could differ materially from those contained or implied
by such statements for a variety of factors, including: changes in economic conditions; movements in interest rates;
competitive pressures on product pricing and services; success and timing of business strategies; the nature, extent,
and timing of governmental actions and reforms; and extended disruption of vital infrastructure. All forward-looking
statements included in this current report on Form 8-K are based on information available at the time of the report.
Middlefield Banc Corp. assumes no obligation to update any forward-looking statement.


<P align="left" style="font-size: 10pt">ITEM 9.01 FINANCIAL STATEMENTS AND EXHIBITS


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    <TD width="3%" nowrap align="left">(c)</TD>
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    <TD>Exhibits.</TD>
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<P align="left" style="font-size: 10pt">The following exhibits are furnished herewith:


<P align="left" style="font-size: 10pt">EXHIBITS


<P align="left" style="font-size: 10pt">99 &nbsp;&nbsp;&nbsp;October&nbsp;21, 2008 press release of Middlefield Banc Corp.


<P align="center" style="font-size: 10pt">SIGNATURES



<P align="left" style="font-size: 10pt; text-indent: 4%">Pursuant to the requirements of the Securities Exchange Act of 1934, the registrant has duly caused this report to
be signed on its behalf by the undersigned hereunto duly authorized.

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    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;
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    <TD>&nbsp;</TD>
    <TD align="left" valign="top">MIDDLEFIELD BANC CORP.</TD>
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    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;
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    <TD>&nbsp;</TD>
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    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">Date: October&nbsp;22, 2008
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">/s/ James R. Heslop, II</TD>
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&nbsp;</DIV></TD>
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    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;
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    <TD>&nbsp;</TD>
    <TD align="left" valign="top">Executive Vice President and COO</TD>
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{"company-data": {"conformed-name": "MIDDLEFIELD BANC CORP", "cik": "0000836147", "assigned-sic": "6022", "irs-number": "341585111", "state-of-incorporation": "OH"}, "filing-values": {"form-type": "8-K", "act": "34", "file-number": "000-32561", "film-number": "081134427"}, "business-address": {"street1": "15985 E HIGH ST", "street2": "P O BOX 35", "city": "MIDDLEFILED", "state": "OH", "zip": "44062-9263", "phone": "4406321666"}, "mail-address": {"street1": "15985 EAST HIGH STREET", "street2": "P O BOX 35", "city": "MIDDLEFIELD", "state": "OH", "zip": "44062-9263"}}
Filed by Bowne Pure Compliance
UNITED STATES
SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 8-K
CURRENT REPORT
Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934
Date of Report (Date of earliest event reported): October 21, 2008
Middlefield Banc Corp.
(Exact name of registrant as specified in its charter)
Ohio
000-32561
34-1585111
(State or other Jurisdiction of Incorporation)
(Commission File Number)
(IRS Employer Identification No.)
15985 East High Street
Middlefield, Ohio
44062
(Address of Principal Executive Offices)
(Zip Code)
Registrant's telephone number, including area code:
(440) 632-1666
(not applicable)
(Former name or former address if changed since last report.)
Check the appropriate box below if the Form 8-K filing is intended to simultaneously satisfy the filing obligation of the registrant
under any of the following provisions:
o
Written communications pursuant to Rule 425 under the Securities Act (17 CFR 230.425)
o
Soliciting material pursuant to Rule 14a-12 under the Exchange Act (17 CFR 240.14a-12)
o
Pre-commencement communications pursuant to Rule 14d-2(b) under the Exchange Act (17 CFR 240.14d-2(b))
o
Pre-commencement communications pursuant to Rule 13e-4(c) under the Exchange Act (17 CFR 240.13e-4(c))
ITEM 2.02 RESULTS OF OPERATIONS AND FINANCIAL CONDITION
The following information is furnished under Item 2.02. On October 21, 2008, Middlefield Banc Corp. issued a
press release announcing financial results for the third quarter and nine month period ended September 30, 2008. A
copy of the press release is attached hereto as Exhibit 99 and is incorporated herein by this reference.
The information contained or incorporated by reference in this current report on Form 8-K may contain
forward-looking statements, including certain plans, expectations, goals, and projections, which are subject to
numerous assumptions, risks, and uncertainties. Actual results could differ materially from those contained or implied
by such statements for a variety of factors, including: changes in economic conditions; movements in interest rates;
competitive pressures on product pricing and services; success and timing of business strategies; the nature, extent,
and timing of governmental actions and reforms; and extended disruption of vital infrastructure. All forward-looking
statements included in this current report on Form 8-K are based on information available at the time of the report.
Middlefield Banc Corp. assumes no obligation to update any forward-looking statement.
ITEM 9.01 FINANCIAL STATEMENTS AND EXHIBITS
(c)
Exhibits.
The following exhibits are furnished herewith:
EXHIBITS
99    October 21, 2008 press release of Middlefield Banc Corp.
SIGNATURES
Pursuant to the requirements of the Securities Exchange Act of 1934, the registrant has duly caused this report to
be signed on its behalf by the undersigned hereunto duly authorized.
MIDDLEFIELD BANC CORP.
Date: October 22, 2008
/s/ James R. Heslop, II
Executive Vice President and COO