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<P style="font-size: 14pt" align="center"><B>UNITED STATES<BR>
SECURITIES AND
EXCHANGE COMMISSION<BR>
<FONT style="font-size: 12pt">Washington, D.C. 20549
</FONT></B>

<P style="font-size: 18pt" align="center"><B>FORM 8-K</B>

<P style="font-size: 12pt" align="center"><B>CURRENT REPORT<BR>
Pursuant to
Section 13 or 15(d) of the Securities Exchange Act of 1934</B>

<P style="font-size: 10pt" align="center"><B>Date of Report (Date of earliest
event reported): December 2, 2008</B>

<P style="font-size: 24pt" align="center"><B>POLYMEDIX, INC.<BR>
</B><FONT
style="font-size: 10pt">(Exact name of registrant as specified in its charter)
</FONT>
<TABLE style="font-size: 10pt; text-align: center" cellspacing="0"
cellpadding="0" width="100%" border="0">

 <TR>
  <TD width="32%">&nbsp;</TD>
  <TD width="1%">&nbsp;</TD>
  <TD width="33%">&nbsp;</TD>
  <TD width="1%">&nbsp;</TD>
  <TD width="32%">&nbsp;</TD>
 </TR>
 <TR valign="bottom">
  <TD style="border-bottom: #000000 1px solid"><B>Delaware</B></TD>
  <TD>&nbsp;</TD>
  <TD style="border-bottom: #000000 1px solid"><B>000-51895</B></TD>
  <TD>&nbsp;</TD>
  <TD style="border-bottom: #000000 1px solid"><B>27-0125925</B></TD>
 </TR>
 <TR valign="top">
  <TD>(State or other Jurisdiction of Incorporation)</TD>
  <TD>&nbsp;</TD>
  <TD>(Commission File Number)</TD>
  <TD>&nbsp;</TD>
  <TD>(IRS Employer Identification No.)</TD>
 </TR>

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cellpadding="0" width="100%" border="0">

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  <TD width="49%">&nbsp;</TD>
  <TD width="1%">&nbsp;</TD>
  <TD width="49%">&nbsp;</TD>
 </TR>
 <TR valign="bottom">
  <TD style="border-bottom: #000000 1px solid"><B>170 N. Radnor Chester
Road<BR>
Suite 300<BR>
Radnor, PA<BR>
</B></TD>
  <TD>&nbsp;</TD>
  <TD style="border-bottom: #000000 1px solid"><B>19087</B></TD>
 </TR>
 <TR valign="top">
  <TD>(Address of Principal Executive Offices)</TD>
  <TD>&nbsp;</TD>
  <TD>(Zip Code)</TD>
 </TR>

</TABLE>


<P style="font-size: 10pt" align="center">Registrant&#8217;s telephone number,
including area code: <B>484-598-2400</B>
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cellpadding="0" width="30%" border="0">

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  <TD width="100%">&nbsp;</TD>
 </TR>
 <TR>
  <TD style="border-bottom: #000000 1px solid" nowrap><B>Not
Applicable<BR>
</B></TD>
 </TR>
 <TR>
  <TD nowrap>(Former name or former address if changed since last report.)</TD>
 </TR>

</TABLE>


<P style="font-size: 10pt" align="left">Check the appropriate box below if the
Form 8-K filing is intended to simultaneously satisfy the filing obligation of
the registrant under any of the following provisions:

<P style="font-size: 10pt" align="left"><FONT face="Wingdings">o</FONT> Written
communications pursuant to Rule 425 under the Securities Act (17 CFR
230.425)<BR>
<BR>
<FONT face="Wingdings">o</FONT> Soliciting material pursuant
to Rule 14a-12 under the Exchange Act (17 CFR 240.14a-12)<BR>
<BR>
<FONT
face="Wingdings">o</FONT> Pre-commencement communications pursuant to Rule
14d-2(b) under the Exchange Act (17 CFR 240.14d-2(b))<BR>
<BR>
<FONT
face="Wingdings">o</FONT> Pre-commencement communications pursuant to Rule
13e-4(c) under the Exchange Act (17 CFR 240.13e-4(c))<BR>



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<P style="font-size: 10pt" align="justify"><B>Item&nbsp;5.02 Departure of
Directors or Certain Officers; Election of Directors; Appointment of Certain
Officers; Compensatory Arrangements of Certain Officers.</B>

<P style="font-size: 10pt" align="justify">(b)&nbsp;effective December&nbsp;2,
2008, Dawn Eringis assumed the position of part-time Director of Business
Development of PolyMedix, Inc. (the &#8220;Company&#8221;).

<P style="font-size: 10pt" align="justify">(e)&nbsp;The Company hired James
Gregory Ford to serve as the Company&#8217;s Vice President of Business
Development, beginning on December&nbsp;2, 2008. Under the terms of
Mr.&nbsp;Ford&#8217;s offer letter (the &#8220;Offer Letter&#8221;),
Mr.&nbsp;Ford will receive an initial annual salary of $260,000 per year,
subject to possible adjustment based on personal and Company performance.
Mr.&nbsp;Ford will be eligible to receive a discretionary cash bonus. For 2009,
Mr.&nbsp;Ford may receive a maximum potential bonus of up to 100% of his base
salary for deals in which Mr.&nbsp;Ford was the primary and lead negotiator and
essential to concluding and based on (i)&nbsp;one percent (1%) of cash revenues
actually received by the Company in 2009 for out-licensing deals,
(ii)&nbsp;equity investments actually received in 2009 made by corporate
partners as part of a strategic investment or business opportunity, and
(iii)&nbsp;a 35% bonus payment for in-licensing deals of a marketed or clinical
stage Low Molecular Weight Heparin product, or a to be determined amount for
any other clinical stage product . Mr.&nbsp;Ford may also choose within the
first twelve months of employment to receive a payment in the gross-amount of
$40,000 to assist in relocation expenses. In addition, Mr.&nbsp;Ford will be
granted (the &#8220;Initial Grant&#8221;) options to purchase 400,000 shares of
the Company&#8217;s common stock, vesting 50% on the second anniversary of the
grant date and the remainder monthly thereafter over the third and fourth years
from the grant date. Further, Mr.&nbsp;Ford will be eligible to participate in
all Company employee benefit programs.

<P style="font-size: 10pt" align="justify">Mr.&nbsp;Ford may resign or
his employment may be terminated by the Company at any time. If
Mr.&nbsp;Ford&#8217;s employment is terminated as a result of a Qualified
Termination (as defined in the Offer Letter), then Mr.&nbsp;Ford will be
entitled to: (i)&nbsp;continuation of his base salary for one (1)&nbsp;year,
(ii)&nbsp;Company payments of COBRA premiums for up to twelve months following
termination, and (iii)&nbsp;full vesting of any unvested stock options.
Mr.&nbsp;Ford&#8217;s right to any such payments, vesting and/or grants and
benefits will be conditioned upon the execution of a customary release of all
claims against the Company and its affiliates and representatives by
Mr.&nbsp;Ford. However, if a Qualified Termination occurs within 24 months of
the commencement of Mr.&nbsp;Ford&#8217;s employment, 200,000 options of the
Initial Grant will vest in lieu of the schedule in (iii)&nbsp;above. In
addition, if Mr.&nbsp;Ford voluntarily resigns from the Company within
24&nbsp;months of accepting the relocation payment, or if he is terminated for
Cause (as defined in the Offer Letter), Mr.&nbsp;Ford must repay to the Company the amount of the relocation
payment.

<P style="font-size: 10pt" align="justify">The description of the material
terms of Mr.&nbsp;Ford&#8217;s employment in this Item&nbsp;5.02(e) is
qualified in its entirety by reference to the full text of the Offer Letter, a
copy of which is attached as Exhibit&nbsp;10.1 to this Current Report on Form
8-K and incorporated herein by reference.

<P style="font-size: 10pt" align="justify"><B>Item&nbsp;9.</B><B>01(d)</B><B>
Financial Statements and Exhibits.</B>

<P style="font-size: 10pt" align="justify">10.1 Offer Letter to James Gregory
Ford.

<P style="font-size: 10pt" align="justify">99.1 Press Release issued
December&nbsp;2, 2008 announcing the hiring of James Gregory Ford.

<P style="font-size: 10pt" align="center">&nbsp;

<P style="display: none; font-size: 10pt" align="center">2
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<P style="font-size: 10pt" align="center"><B>SIGNATURE</B>

<P style="font-size: 10pt" align="justify">Pursuant to the requirements of the
Securities Exchange Act of 1934, the registrant has duly caused this report to
be signed on its behalf by the undersigned hereunto duly authorized.

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 <TR valign="bottom">
  <TD>&nbsp;</TD>
  <TD valign="top" align="left" colspan="2"><B>POLYMEDIX, INC.</B></TD>
</TR>

<TR><TD>&nbsp;</TD></TR>


 <TR valign="bottom">
  <TD valign="top">Date: December&nbsp;4, 2008</TD>
  <TD align="left">By: &nbsp;</TD>
  <TD valign="top" align="left" style="border-bottom: #000000 1px solid">/s/ Edward Smith</TD>
 </TR>

 <TR valign="bottom">
  <TD valign="top">&nbsp;</TD>
  <TD align="left">Name:&nbsp;</TD>
  <TD valign="top" align="left">Edward Smith</TD>
 </TR>

 <TR valign="bottom">
  <TD valign="top">&nbsp;</TD>
  <TD align="left">Title:&nbsp;</TD>
  <TD valign="top" align="left">Vice President, Finance and Chief Financial Officer</TD>
 </TR>

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<P style="font-size: 10pt" align="center">&nbsp;

<P style="font-size: 10pt" align="center">&nbsp;

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<P style="font-size: 10pt" align="center">Index to Exhibits

<P style="font-size: 10pt" align="justify">10.1 Offer Letter to James Gregory
Ford.


<P style="font-size: 10pt" align="justify">99.1 Press Release issued December&nbsp;2, 2008 announcing the hiring of James Gregory Ford.

<P style="font-size: 10pt" align="center">&nbsp;

<P style="display: none; font-size: 10pt" align="center">4
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Filed by Bowne Pure Compliance
UNITED STATES
SECURITIES AND
EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 8-K
CURRENT REPORT
Pursuant to
Section 13 or 15(d) of the Securities Exchange Act of 1934
Date of Report (Date of earliest
event reported): December 2, 2008
POLYMEDIX, INC.
(Exact name of registrant as specified in its charter)
Delaware
000-51895
27-0125925
(State or other Jurisdiction of Incorporation)
(Commission File Number)
(IRS Employer Identification No.)
170 N. Radnor Chester
Road
Suite 300
Radnor, PA
19087
(Address of Principal Executive Offices)
(Zip Code)
Registrant's telephone number,
including area code:
484-598-2400
Not
Applicable
(Former name or former address if changed since last report.)
Check the appropriate box below if the
Form 8-K filing is intended to simultaneously satisfy the filing obligation of
the registrant under any of the following provisions:
o
Written
communications pursuant to Rule 425 under the Securities Act (17 CFR
230.425)
o
Soliciting material pursuant
to Rule 14a-12 under the Exchange Act (17 CFR 240.14a-12)
o
Pre-commencement communications pursuant to Rule
14d-2(b) under the Exchange Act (17 CFR 240.14d-2(b))
o
Pre-commencement communications pursuant to Rule
13e-4(c) under the Exchange Act (17 CFR 240.13e-4(c))
Item 5.02 Departure of
Directors or Certain Officers; Election of Directors; Appointment of Certain
Officers; Compensatory Arrangements of Certain Officers.
(b) effective December 2,
2008, Dawn Eringis assumed the position of part-time Director of Business
Development of PolyMedix, Inc. (the "Company").
(e) The Company hired James
Gregory Ford to serve as the Company's Vice President of Business
Development, beginning on December 2, 2008. Under the terms of
Mr. Ford's offer letter (the "Offer Letter"),
Mr. Ford will receive an initial annual salary of $260,000 per year,
subject to possible adjustment based on personal and Company performance.
Mr. Ford will be eligible to receive a discretionary cash bonus. For 2009,
Mr. Ford may receive a maximum potential bonus of up to 100% of his base
salary for deals in which Mr. Ford was the primary and lead negotiator and
essential to concluding and based on (i) one percent (1%) of cash revenues
actually received by the Company in 2009 for out-licensing deals,
(ii) equity investments actually received in 2009 made by corporate
partners as part of a strategic investment or business opportunity, and
(iii) a 35% bonus payment for in-licensing deals of a marketed or clinical
stage Low Molecular Weight Heparin product, or a to be determined amount for
any other clinical stage product . Mr. Ford may also choose within the
first twelve months of employment to receive a payment in the gross-amount of
$40,000 to assist in relocation expenses. In addition, Mr. Ford will be
granted (the "Initial Grant") options to purchase 400,000 shares of
the Company's common stock, vesting 50% on the second anniversary of the
grant date and the remainder monthly thereafter over the third and fourth years
from the grant date. Further, Mr. Ford will be eligible to participate in
all Company employee benefit programs.
Mr. Ford may resign or
his employment may be terminated by the Company at any time. If
Mr. Ford's employment is terminated as a result of a Qualified
Termination (as defined in the Offer Letter), then Mr. Ford will be
entitled to: (i) continuation of his base salary for one (1) year,
(ii) Company payments of COBRA premiums for up to twelve months following
termination, and (iii) full vesting of any unvested stock options.
Mr. Ford's right to any such payments, vesting and/or grants and
benefits will be conditioned upon the execution of a customary release of all
claims against the Company and its affiliates and representatives by
Mr. Ford. However, if a Qualified Termination occurs within 24 months of
the commencement of Mr. Ford's employment, 200,000 options of the
Initial Grant will vest in lieu of the schedule in (iii) above. In
addition, if Mr. Ford voluntarily resigns from the Company within
24 months of accepting the relocation payment, or if he is terminated for
Cause (as defined in the Offer Letter), Mr. Ford must repay to the Company the amount of the relocation
payment.
The description of the material
terms of Mr. Ford's employment in this Item 5.02(e) is
qualified in its entirety by reference to the full text of the Offer Letter, a
copy of which is attached as Exhibit 10.1 to this Current Report on Form
8-K and incorporated herein by reference.
Item 9.
01(d)
Financial Statements and Exhibits.
10.1 Offer Letter to James Gregory
Ford.
99.1 Press Release issued
December 2, 2008 announcing the hiring of James Gregory Ford.
SIGNATURE
Pursuant to the requirements of the
Securities Exchange Act of 1934, the registrant has duly caused this report to
be signed on its behalf by the undersigned hereunto duly authorized.
POLYMEDIX, INC.
Date: December 4, 2008
By:
/s/ Edward Smith
Name:
Edward Smith
Title:
Vice President, Finance and Chief Financial Officer
Index to Exhibits
10.1 Offer Letter to James Gregory
Ford.
99.1 Press Release issued December 2, 2008 announcing the hiring of James Gregory Ford.