<?xml version="1.0" ?><!--XBRL Document Created with Wdesk from Workiva--><!--Copyright 2022 Workiva--><!--r:a3094557-6cda-48a4-b7a0-aa91b815ef06,g:5d2db364-3774-40ec-b173-bc5d0f3acda7,d:f5bd363b0bfc40ed9dbd518afbc4f8be--><html xmlns="http://www.w3.org/1999/xhtml" xmlns:ixt="http://www.xbrl.org/inlineXBRL/transformation/2020-02-12" xmlns:ix="http://www.xbrl.org/2013/inlineXBRL" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xbrli="http://www.xbrl.org/2003/instance" xmlns:link="http://www.xbrl.org/2003/linkbase" xmlns:ixt-sec="http://www.sec.gov/inlineXBRL/transformation/2015-08-31" xmlns:dei="http://xbrl.sec.gov/dei/2021" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="en-US"><head><meta http-equiv="Content-Type" content="text/html"/>


<title>zgnx-20220228</title></head><body><div style="display:none"><ix:header><ix:hidden><ix:nonNumeric contextRef="i5cbfcea5c9f743e1bf8f224b8022bf0e_D20220228-20220228" name="dei:EntityCentralIndexKey" id="id3VybDovL2RvY3MudjEvZG9jOmY1YmQzNjNiMGJmYzQwZWQ5ZGJkNTE4YWZiYzRmOGJlL3NlYzpmNWJkMzYzYjBiZmM0MGVkOWRiZDUxOGFmYmM0ZjhiZV80L2ZyYWc6Nzg0MDBhYjhiZjEzNDE0NWI0ZDE2YTI2YzcyM2QyYjMvdGFibGU6ZWRhZmVmMmFmY2U3NGY2NGI1NGI5NjZlMGQzYjU3YzQvdGFibGVyYW5nZTplZGFmZWYyYWZjZTc0ZjY0YjU0Yjk2NmUwZDNiNTdjNF82LTEtMS0xLTM1NDg5_6c1c90ce-2eaf-45bf-868d-3b2a2c462a4a">0001375151</ix:nonNumeric><ix:nonNumeric contextRef="i5cbfcea5c9f743e1bf8f224b8022bf0e_D20220228-20220228" name="dei:AmendmentFlag" format="ixt:fixed-false" id="id3VybDovL2RvY3MudjEvZG9jOmY1YmQzNjNiMGJmYzQwZWQ5ZGJkNTE4YWZiYzRmOGJlL3NlYzpmNWJkMzYzYjBiZmM0MGVkOWRiZDUxOGFmYmM0ZjhiZV80L2ZyYWc6Nzg0MDBhYjhiZjEzNDE0NWI0ZDE2YTI2YzcyM2QyYjMvdGFibGU6ZWRhZmVmMmFmY2U3NGY2NGI1NGI5NjZlMGQzYjU3YzQvdGFibGVyYW5nZTplZGFmZWYyYWZjZTc0ZjY0YjU0Yjk2NmUwZDNiNTdjNF83LTEtMS0xLTM1NDg5_6577c385-1c2c-4552-8e6a-62eb3a4ede03">FALSE</ix:nonNumeric></ix:hidden><ix:references xml:lang="en-US"><link:schemaRef xlink:type="simple" xlink:href="zgnx-20220228.xsd"></link:schemaRef></ix:references><ix:resources><xbrli:context id="i5cbfcea5c9f743e1bf8f224b8022bf0e_D20220228-20220228"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0001375151</xbrli:identifier></xbrli:entity><xbrli:period><xbrli:startDate>2022-02-28</xbrli:startDate><xbrli:endDate>2022-02-28</xbrli:endDate></xbrli:period></xbrli:context></ix:resources></ix:header></div><div id="if5bd363b0bfc40ed9dbd518afbc4f8be_1"></div><div style="min-height:21.6pt;width:100%"><div><span><br/></span></div></div><div style="-sec-extract:summary;text-align:center"><table style="border-collapse:collapse;display:inline-table;margin-bottom:5pt;vertical-align:text-bottom;width:99.341%"><tr><td style="width:1.0%"></td><td style="width:20.185%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:17.900%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:17.900%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:17.900%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:20.615%"></td><td style="width:0.1%"></td></tr><tr style="height:3pt"><td colspan="3" style="border-top:0.5pt solid #000;padding:0 1pt"></td><td colspan="3" style="border-top:0.5pt solid #000;padding:0 1pt"></td><td colspan="3" style="border-top:0.5pt solid #000;padding:0 1pt"></td><td colspan="3" style="border-top:0.5pt solid #000;padding:0 1pt"></td><td colspan="3" style="border-top:0.5pt solid #000;padding:0 1pt"></td></tr></table></div><div style="text-align:center"><span style="color:#000000;font-family:'Arial',sans-serif;font-size:18pt;font-weight:700;line-height:120%">UNITED STATES</span></div><div style="text-align:center"><span style="color:#000000;font-family:'Arial',sans-serif;font-size:18pt;font-weight:700;line-height:120%">SECURITIES AND EXCHANGE COMMISSION</span></div><div style="text-align:center"><span style="color:#000000;font-family:'Arial',sans-serif;font-size:12pt;font-weight:700;line-height:120%">WASHINGTON, D.C. 20549</span></div><div style="margin-top:9pt;text-align:center"><table style="border-collapse:collapse;display:inline-table;margin-bottom:5pt;vertical-align:text-bottom;width:96.787%"><tr><td style="width:1.0%"></td><td style="width:15.468%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:15.468%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:15.468%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:15.762%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:15.468%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:15.766%"></td><td style="width:0.1%"></td></tr><tr style="height:3pt"><td colspan="3" style="padding:0 1pt"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="3" style="border-top:1pt solid #000000;padding:0 1pt"></td><td colspan="3" style="border-top:1pt solid #000000;padding:0 1pt"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="3" style="padding:0 1pt"></td></tr></table></div><div style="margin-bottom:4.5pt;margin-top:4.5pt;text-align:center"><span style="color:#000000;font-family:'Arial',sans-serif;font-size:22pt;font-weight:700;line-height:120%">FORM <ix:nonNumeric contextRef="i5cbfcea5c9f743e1bf8f224b8022bf0e_D20220228-20220228" name="dei:DocumentType" id="id3VybDovL2RvY3MudjEvZG9jOmY1YmQzNjNiMGJmYzQwZWQ5ZGJkNTE4YWZiYzRmOGJlL3NlYzpmNWJkMzYzYjBiZmM0MGVkOWRiZDUxOGFmYmM0ZjhiZV8xL2ZyYWc6Nzc5MzU2MDNhNzRkNGZhZmEzMGVlM2RmNDlhZGNhZTQvdGV4dHJlZ2lvbjo3NzkzNTYwM2E3NGQ0ZmFmYTMwZWUzZGY0OWFkY2FlNF84Ng_4ec9e1f4-7da1-42d7-8d4c-9d2e65924782">8-K</ix:nonNumeric></span></div><div style="margin-bottom:18pt;margin-top:9pt;text-align:center"><table style="border-collapse:collapse;display:inline-table;margin-bottom:5pt;vertical-align:text-bottom;width:96.787%"><tr><td style="width:1.0%"></td><td style="width:15.468%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:15.468%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:15.468%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:15.762%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:15.468%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:15.766%"></td><td style="width:0.1%"></td></tr><tr style="height:3pt"><td colspan="3" style="padding:0 1pt"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="3" style="border-top:1pt solid #000000;padding:0 1pt"></td><td colspan="3" style="border-top:1pt solid #000000;padding:0 1pt"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="3" style="padding:0 1pt"></td></tr></table></div><div style="margin-top:9pt;text-align:center"><span style="color:#000000;font-family:'Arial',sans-serif;font-size:12pt;font-weight:700;line-height:120%">CURRENT REPORT</span></div><div style="text-align:center"><span style="color:#000000;font-family:'Arial',sans-serif;font-size:12pt;font-weight:700;line-height:120%">Pursuant to Section&#160;13 or 15(d)</span></div><div style="text-align:center"><span style="color:#000000;font-family:'Arial',sans-serif;font-size:12pt;font-weight:700;line-height:120%">of the Securities Exchange Act of 1934</span></div><div style="margin-top:9pt;text-align:center"><span style="color:#000000;font-family:'Arial',sans-serif;font-size:12pt;font-weight:700;line-height:120%">Date of Report (Date of earliest event reported): <ix:nonNumeric contextRef="i5cbfcea5c9f743e1bf8f224b8022bf0e_D20220228-20220228" name="dei:DocumentPeriodEndDate" format="ixt:date-monthname-day-year-en" id="id3VybDovL2RvY3MudjEvZG9jOmY1YmQzNjNiMGJmYzQwZWQ5ZGJkNTE4YWZiYzRmOGJlL3NlYzpmNWJkMzYzYjBiZmM0MGVkOWRiZDUxOGFmYmM0ZjhiZV8xL2ZyYWc6Nzc5MzU2MDNhNzRkNGZhZmEzMGVlM2RmNDlhZGNhZTQvdGV4dHJlZ2lvbjo3NzkzNTYwM2E3NGQ0ZmFmYTMwZWUzZGY0OWFkY2FlNF8yMjc_2a1a419f-5aac-4cdc-a016-8fcf19e545ce">February 28, 2022</ix:nonNumeric></span></div><div style="margin-top:9pt;text-align:center"><table style="border-collapse:collapse;display:inline-table;margin-bottom:5pt;vertical-align:text-bottom;width:96.787%"><tr><td style="width:1.0%"></td><td style="width:15.468%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:15.468%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:15.468%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:15.762%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:15.468%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:15.766%"></td><td style="width:0.1%"></td></tr><tr style="height:3pt"><td colspan="3" style="padding:0 1pt"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="3" style="border-top:1pt solid #000000;padding:0 1pt"></td><td colspan="3" style="border-top:1pt solid #000000;padding:0 1pt"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="3" style="padding:0 1pt"></td></tr></table></div><div style="text-align:center"><span style="color:#000000;font-family:'Arial',sans-serif;font-size:24pt;font-weight:700;line-height:120%"><ix:nonNumeric contextRef="i5cbfcea5c9f743e1bf8f224b8022bf0e_D20220228-20220228" name="dei:EntityRegistrantName" id="id3VybDovL2RvY3MudjEvZG9jOmY1YmQzNjNiMGJmYzQwZWQ5ZGJkNTE4YWZiYzRmOGJlL3NlYzpmNWJkMzYzYjBiZmM0MGVkOWRiZDUxOGFmYmM0ZjhiZV8xL2ZyYWc6Nzc5MzU2MDNhNzRkNGZhZmEzMGVlM2RmNDlhZGNhZTQvdGV4dHJlZ2lvbjo3NzkzNTYwM2E3NGQ0ZmFmYTMwZWUzZGY0OWFkY2FlNF8yMzI_46b29fc8-e482-4f35-b6c7-703283172800">ZOGENIX, INC.</ix:nonNumeric></span></div><div style="text-align:center"><span style="color:#000000;font-family:'Arial',sans-serif;font-size:10pt;font-weight:700;line-height:120%">(Exact Name of Registrant as Specified in its Charter)<br/></span><table style="border-collapse:collapse;display:inline-table;margin-bottom:5pt;vertical-align:text-bottom;width:96.787%"><tr><td style="width:1.0%"></td><td style="width:15.468%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:15.468%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:15.468%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:15.762%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:15.468%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:15.766%"></td><td style="width:0.1%"></td></tr><tr style="height:3pt"><td colspan="3" style="padding:0 1pt"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="3" style="border-top:1pt solid #000000;padding:0 1pt"></td><td colspan="3" style="border-top:1pt solid #000000;padding:0 1pt"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="3" style="padding:0 1pt"></td></tr></table></div><div style="text-align:center"><table style="border-collapse:collapse;display:inline-table;margin-bottom:5pt;vertical-align:text-bottom;width:99.341%"><tr><td style="width:1.0%"></td><td style="width:40.328%"></td><td style="width:0.1%"></td><td style="width:0.1%"></td><td style="width:0.657%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:15.042%"></td><td style="width:0.1%"></td><td style="width:0.1%"></td><td style="width:0.371%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:39.902%"></td><td style="width:0.1%"></td></tr><tr style="height:3pt"><td colspan="3" style="padding:0 1pt"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="3" style="padding:0 1pt"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:center;vertical-align:bottom"><span style="color:#000000;font-family:'Arial',sans-serif;font-size:10pt;font-weight:700;line-height:100%"><ix:nonNumeric contextRef="i5cbfcea5c9f743e1bf8f224b8022bf0e_D20220228-20220228" name="dei:EntityIncorporationStateCountryCode" format="ixt-sec:stateprovnameen" id="id3VybDovL2RvY3MudjEvZG9jOmY1YmQzNjNiMGJmYzQwZWQ5ZGJkNTE4YWZiYzRmOGJlL3NlYzpmNWJkMzYzYjBiZmM0MGVkOWRiZDUxOGFmYmM0ZjhiZV8xL2ZyYWc6Nzc5MzU2MDNhNzRkNGZhZmEzMGVlM2RmNDlhZGNhZTQvdGFibGU6ZWQ4YWZiOWM1NGFiNDc3NWE1NThiZDUzZDRkNWY5NzMvdGFibGVyYW5nZTplZDhhZmI5YzU0YWI0Nzc1YTU1OGJkNTNkNGQ1Zjk3M18xLTAtMS0xLTM1NDg5_f4ec9359-9126-4c44-9361-7e802e51768d">Delaware</ix:nonNumeric></span></td><td colspan="3" style="padding:0 1pt"></td><td colspan="3" style="padding:2px 1pt;text-align:center;vertical-align:bottom"><span style="color:#000000;font-family:'Arial',sans-serif;font-size:10pt;font-weight:700;line-height:100%"><ix:nonNumeric contextRef="i5cbfcea5c9f743e1bf8f224b8022bf0e_D20220228-20220228" name="dei:EntityFileNumber" id="id3VybDovL2RvY3MudjEvZG9jOmY1YmQzNjNiMGJmYzQwZWQ5ZGJkNTE4YWZiYzRmOGJlL3NlYzpmNWJkMzYzYjBiZmM0MGVkOWRiZDUxOGFmYmM0ZjhiZV8xL2ZyYWc6Nzc5MzU2MDNhNzRkNGZhZmEzMGVlM2RmNDlhZGNhZTQvdGFibGU6ZWQ4YWZiOWM1NGFiNDc3NWE1NThiZDUzZDRkNWY5NzMvdGFibGVyYW5nZTplZDhhZmI5YzU0YWI0Nzc1YTU1OGJkNTNkNGQ1Zjk3M18xLTItMS0xLTM1NDg5_b40776c6-7218-4f0d-adf6-8a02043a6aed">001-34962</ix:nonNumeric></span></td><td colspan="3" style="padding:0 1pt"></td><td colspan="3" style="padding:2px 1pt;text-align:center;vertical-align:bottom"><span style="color:#000000;font-family:'Arial',sans-serif;font-size:10pt;font-weight:700;line-height:100%"><ix:nonNumeric contextRef="i5cbfcea5c9f743e1bf8f224b8022bf0e_D20220228-20220228" name="dei:EntityTaxIdentificationNumber" id="id3VybDovL2RvY3MudjEvZG9jOmY1YmQzNjNiMGJmYzQwZWQ5ZGJkNTE4YWZiYzRmOGJlL3NlYzpmNWJkMzYzYjBiZmM0MGVkOWRiZDUxOGFmYmM0ZjhiZV8xL2ZyYWc6Nzc5MzU2MDNhNzRkNGZhZmEzMGVlM2RmNDlhZGNhZTQvdGFibGU6ZWQ4YWZiOWM1NGFiNDc3NWE1NThiZDUzZDRkNWY5NzMvdGFibGVyYW5nZTplZDhhZmI5YzU0YWI0Nzc1YTU1OGJkNTNkNGQ1Zjk3M18xLTQtMS0xLTM1NDg5_d0967266-0a60-44ff-b6e1-5742d99888a7">20-5300780</ix:nonNumeric></span></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:center;vertical-align:top"><span style="color:#000000;font-family:'Arial',sans-serif;font-size:8pt;font-weight:400;line-height:100%">(State or Other Jurisdiction<br/>of Incorporation)</span></td><td colspan="3" style="padding:0 1pt"></td><td colspan="3" style="padding:2px 1pt;text-align:center;vertical-align:top"><span style="color:#000000;font-family:'Arial',sans-serif;font-size:8pt;font-weight:400;line-height:100%">(Commission<br/>File Number)</span></td><td colspan="3" style="padding:0 1pt"></td><td colspan="3" style="padding:2px 1pt;text-align:center;vertical-align:top"><span style="color:#000000;font-family:'Arial',sans-serif;font-size:8pt;font-weight:400;line-height:100%">(IRS Employer<br/>Identification No.)</span></td></tr></table></div><div><table style="border-collapse:collapse;display:inline-table;margin-bottom:5pt;vertical-align:text-bottom;width:99.341%"><tr><td style="width:0.1%"></td><td style="width:0.371%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:47.900%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:6.328%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:41.901%"></td><td style="width:0.1%"></td></tr><tr style="height:3pt"><td colspan="3" style="padding:0 1pt"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="3" style="padding:0 1pt"></td></tr><tr><td colspan="3" style="padding:0 1pt"></td><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:top"><div style="text-align:center"><span style="color:#000000;font-family:'Arial',sans-serif;font-size:10pt;font-weight:700;line-height:100%"><ix:nonNumeric contextRef="i5cbfcea5c9f743e1bf8f224b8022bf0e_D20220228-20220228" name="dei:EntityAddressAddressLine1" id="id3VybDovL2RvY3MudjEvZG9jOmY1YmQzNjNiMGJmYzQwZWQ5ZGJkNTE4YWZiYzRmOGJlL3NlYzpmNWJkMzYzYjBiZmM0MGVkOWRiZDUxOGFmYmM0ZjhiZV8xL2ZyYWc6Nzc5MzU2MDNhNzRkNGZhZmEzMGVlM2RmNDlhZGNhZTQvdGFibGU6OGIwNDAzYjgxN2EzNDI0M2JmZTgyMjEyYTAxODcwODUvdGFibGVyYW5nZTo4YjA0MDNiODE3YTM0MjQzYmZlODIyMTJhMDE4NzA4NV8xLTEtMS0xLTM1NDg5L3RleHRyZWdpb246ZmZhZTMzMTIwNGFkNGEyMTkxNTVlNjAxMzQ5MzIyOWRfNA_0e4bc855-b0f1-4b6f-88d2-99ba6e1b2583">5959 Horton Street</ix:nonNumeric>, <ix:nonNumeric contextRef="i5cbfcea5c9f743e1bf8f224b8022bf0e_D20220228-20220228" name="dei:EntityAddressAddressLine2" id="id3VybDovL2RvY3MudjEvZG9jOmY1YmQzNjNiMGJmYzQwZWQ5ZGJkNTE4YWZiYzRmOGJlL3NlYzpmNWJkMzYzYjBiZmM0MGVkOWRiZDUxOGFmYmM0ZjhiZV8xL2ZyYWc6Nzc5MzU2MDNhNzRkNGZhZmEzMGVlM2RmNDlhZGNhZTQvdGFibGU6OGIwNDAzYjgxN2EzNDI0M2JmZTgyMjEyYTAxODcwODUvdGFibGVyYW5nZTo4YjA0MDNiODE3YTM0MjQzYmZlODIyMTJhMDE4NzA4NV8xLTEtMS0xLTM1NDg5L3RleHRyZWdpb246ZmZhZTMzMTIwNGFkNGEyMTkxNTVlNjAxMzQ5MzIyOWRfOA_61ca4b50-1df5-4cd4-9dda-ad755bdb949b">Suite 500</ix:nonNumeric>, <ix:nonNumeric contextRef="i5cbfcea5c9f743e1bf8f224b8022bf0e_D20220228-20220228" name="dei:EntityAddressCityOrTown" id="id3VybDovL2RvY3MudjEvZG9jOmY1YmQzNjNiMGJmYzQwZWQ5ZGJkNTE4YWZiYzRmOGJlL3NlYzpmNWJkMzYzYjBiZmM0MGVkOWRiZDUxOGFmYmM0ZjhiZV8xL2ZyYWc6Nzc5MzU2MDNhNzRkNGZhZmEzMGVlM2RmNDlhZGNhZTQvdGFibGU6OGIwNDAzYjgxN2EzNDI0M2JmZTgyMjEyYTAxODcwODUvdGFibGVyYW5nZTo4YjA0MDNiODE3YTM0MjQzYmZlODIyMTJhMDE4NzA4NV8xLTEtMS0xLTM1NDg5L3RleHRyZWdpb246ZmZhZTMzMTIwNGFkNGEyMTkxNTVlNjAxMzQ5MzIyOWRfMTI_88ff6efb-9eb8-44b1-9fe4-5c3b8df58e6b">Emeryville</ix:nonNumeric>, <ix:nonNumeric contextRef="i5cbfcea5c9f743e1bf8f224b8022bf0e_D20220228-20220228" name="dei:EntityAddressStateOrProvince" format="ixt-sec:stateprovnameen" id="id3VybDovL2RvY3MudjEvZG9jOmY1YmQzNjNiMGJmYzQwZWQ5ZGJkNTE4YWZiYzRmOGJlL3NlYzpmNWJkMzYzYjBiZmM0MGVkOWRiZDUxOGFmYmM0ZjhiZV8xL2ZyYWc6Nzc5MzU2MDNhNzRkNGZhZmEzMGVlM2RmNDlhZGNhZTQvdGFibGU6OGIwNDAzYjgxN2EzNDI0M2JmZTgyMjEyYTAxODcwODUvdGFibGVyYW5nZTo4YjA0MDNiODE3YTM0MjQzYmZlODIyMTJhMDE4NzA4NV8xLTEtMS0xLTM1NDg5L3RleHRyZWdpb246ZmZhZTMzMTIwNGFkNGEyMTkxNTVlNjAxMzQ5MzIyOWRfMTY_3807c063-9c25-4e06-9535-9656d97de8b2">California</ix:nonNumeric></span></div></td><td colspan="3" style="padding:0 1pt"></td><td colspan="3" style="padding:2px 1pt;text-align:center;vertical-align:top"><span style="color:#000000;font-family:'Arial',sans-serif;font-size:10pt;font-weight:700;line-height:100%"><ix:nonNumeric contextRef="i5cbfcea5c9f743e1bf8f224b8022bf0e_D20220228-20220228" name="dei:EntityAddressPostalZipCode" id="id3VybDovL2RvY3MudjEvZG9jOmY1YmQzNjNiMGJmYzQwZWQ5ZGJkNTE4YWZiYzRmOGJlL3NlYzpmNWJkMzYzYjBiZmM0MGVkOWRiZDUxOGFmYmM0ZjhiZV8xL2ZyYWc6Nzc5MzU2MDNhNzRkNGZhZmEzMGVlM2RmNDlhZGNhZTQvdGFibGU6OGIwNDAzYjgxN2EzNDI0M2JmZTgyMjEyYTAxODcwODUvdGFibGVyYW5nZTo4YjA0MDNiODE3YTM0MjQzYmZlODIyMTJhMDE4NzA4NV8xLTMtMS0xLTM1NDg5_e9e0412d-ee35-4a11-9368-e5c3ac6cadf0">94608</ix:nonNumeric></span></td></tr><tr><td colspan="3" style="padding:0 1pt"></td><td colspan="3" style="padding:2px 1pt;text-align:center;vertical-align:top"><span style="color:#000000;font-family:'Arial',sans-serif;font-size:8pt;font-weight:400;line-height:100%">(Address of Principal Executive Offices)</span></td><td colspan="3" style="padding:0 1pt"></td><td colspan="3" style="padding:2px 1pt;text-align:center;vertical-align:top"><span style="color:#000000;font-family:'Arial',sans-serif;font-size:8pt;font-weight:400;line-height:100%">(Zip Code)</span></td></tr></table></div><div style="margin-top:9pt;text-align:center"><span style="color:#000000;font-family:'Arial',sans-serif;font-size:10pt;font-weight:700;line-height:120%">Registrant&#8217;s telephone number, including area code: (<ix:nonNumeric contextRef="i5cbfcea5c9f743e1bf8f224b8022bf0e_D20220228-20220228" name="dei:CityAreaCode" id="id3VybDovL2RvY3MudjEvZG9jOmY1YmQzNjNiMGJmYzQwZWQ5ZGJkNTE4YWZiYzRmOGJlL3NlYzpmNWJkMzYzYjBiZmM0MGVkOWRiZDUxOGFmYmM0ZjhiZV8xL2ZyYWc6Nzc5MzU2MDNhNzRkNGZhZmEzMGVlM2RmNDlhZGNhZTQvdGV4dHJlZ2lvbjo3NzkzNTYwM2E3NGQ0ZmFmYTMwZWUzZGY0OWFkY2FlNF8zNDk_949a39c1-8c7e-47fd-a2e8-9f8c8ded793e">510</ix:nonNumeric>)&#160;<ix:nonNumeric contextRef="i5cbfcea5c9f743e1bf8f224b8022bf0e_D20220228-20220228" name="dei:LocalPhoneNumber" id="id3VybDovL2RvY3MudjEvZG9jOmY1YmQzNjNiMGJmYzQwZWQ5ZGJkNTE4YWZiYzRmOGJlL3NlYzpmNWJkMzYzYjBiZmM0MGVkOWRiZDUxOGFmYmM0ZjhiZV8xL2ZyYWc6Nzc5MzU2MDNhNzRkNGZhZmEzMGVlM2RmNDlhZGNhZTQvdGV4dHJlZ2lvbjo3NzkzNTYwM2E3NGQ0ZmFmYTMwZWUzZGY0OWFkY2FlNF8zNTM_4f046d85-e79a-4267-93e4-180602aa9eed">550-8300</ix:nonNumeric></span></div><div style="margin-top:9pt;text-align:center"><span style="color:#000000;font-family:'Arial',sans-serif;font-size:8pt;font-weight:400;line-height:120%">(Former Name or Former Address, if Changed Since Last Report.)</span></div><div style="margin-top:6pt;text-align:center"><span style="color:#000000;font-family:'Arial',sans-serif;font-size:10pt;font-weight:400;line-height:120%">Securities registered pursuant to Section 12(b) of the Act:</span><table style="border-collapse:collapse;display:inline-table;margin-bottom:5pt;vertical-align:text-bottom;width:99.341%"><tr><td style="width:1.0%"></td><td style="width:41.185%"></td><td style="width:0.1%"></td><td style="width:0.1%"></td><td style="width:0.371%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:14.328%"></td><td style="width:0.1%"></td><td style="width:0.1%"></td><td style="width:0.514%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:39.902%"></td><td style="width:0.1%"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:center;vertical-align:bottom"><span style="color:#000000;font-family:'Arial',sans-serif;font-size:10pt;font-weight:400;line-height:100%;text-decoration:underline">Title of each class</span></td><td colspan="3" style="padding:0 1pt"></td><td colspan="3" style="padding:2px 1pt;text-align:center;vertical-align:bottom"><span style="color:#000000;font-family:'Arial',sans-serif;font-size:10pt;font-weight:400;line-height:100%;text-decoration:underline">Trading Symbol</span></td><td colspan="3" style="padding:0 1pt"></td><td colspan="3" style="padding:2px 1pt;text-align:center;vertical-align:bottom"><span style="color:#000000;font-family:'Arial',sans-serif;font-size:10pt;font-weight:400;line-height:100%;text-decoration:underline">Name of each exchange on which registered</span></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:center;vertical-align:bottom"><span style="color:#000000;font-family:'Arial',sans-serif;font-size:10pt;font-weight:700;line-height:100%"><ix:nonNumeric contextRef="i5cbfcea5c9f743e1bf8f224b8022bf0e_D20220228-20220228" name="dei:Security12bTitle" id="id3VybDovL2RvY3MudjEvZG9jOmY1YmQzNjNiMGJmYzQwZWQ5ZGJkNTE4YWZiYzRmOGJlL3NlYzpmNWJkMzYzYjBiZmM0MGVkOWRiZDUxOGFmYmM0ZjhiZV8xL2ZyYWc6Nzc5MzU2MDNhNzRkNGZhZmEzMGVlM2RmNDlhZGNhZTQvdGFibGU6MjZhNDg3Nzg0NzQ2NGM3NmE1MDkyYjJmMGU3ODczZWMvdGFibGVyYW5nZToyNmE0ODc3ODQ3NDY0Yzc2YTUwOTJiMmYwZTc4NzNlY18xLTAtMS0xLTM1NDg5_18f17283-678c-4ab1-9edf-410b184533ce">Common Stock, par value $0.001 per share</ix:nonNumeric></span></td><td colspan="3" style="padding:0 1pt"></td><td colspan="3" style="padding:2px 1pt;text-align:center;vertical-align:bottom"><span style="color:#000000;font-family:'Arial',sans-serif;font-size:10pt;font-weight:700;line-height:100%"><ix:nonNumeric contextRef="i5cbfcea5c9f743e1bf8f224b8022bf0e_D20220228-20220228" name="dei:TradingSymbol" id="id3VybDovL2RvY3MudjEvZG9jOmY1YmQzNjNiMGJmYzQwZWQ5ZGJkNTE4YWZiYzRmOGJlL3NlYzpmNWJkMzYzYjBiZmM0MGVkOWRiZDUxOGFmYmM0ZjhiZV8xL2ZyYWc6Nzc5MzU2MDNhNzRkNGZhZmEzMGVlM2RmNDlhZGNhZTQvdGFibGU6MjZhNDg3Nzg0NzQ2NGM3NmE1MDkyYjJmMGU3ODczZWMvdGFibGVyYW5nZToyNmE0ODc3ODQ3NDY0Yzc2YTUwOTJiMmYwZTc4NzNlY18xLTItMS0xLTM1NDg5_d68cfee0-c1df-4fec-8412-0859a2f2b984">ZGNX</ix:nonNumeric></span></td><td colspan="3" style="padding:0 1pt"></td><td colspan="3" style="padding:2px 1pt;text-align:center;vertical-align:bottom"><span style="color:#000000;font-family:'Arial',sans-serif;font-size:10pt;font-weight:700;line-height:100%"><ix:nonNumeric contextRef="i5cbfcea5c9f743e1bf8f224b8022bf0e_D20220228-20220228" name="dei:SecurityExchangeName" format="ixt-sec:exchnameen" id="id3VybDovL2RvY3MudjEvZG9jOmY1YmQzNjNiMGJmYzQwZWQ5ZGJkNTE4YWZiYzRmOGJlL3NlYzpmNWJkMzYzYjBiZmM0MGVkOWRiZDUxOGFmYmM0ZjhiZV8xL2ZyYWc6Nzc5MzU2MDNhNzRkNGZhZmEzMGVlM2RmNDlhZGNhZTQvdGFibGU6MjZhNDg3Nzg0NzQ2NGM3NmE1MDkyYjJmMGU3ODczZWMvdGFibGVyYW5nZToyNmE0ODc3ODQ3NDY0Yzc2YTUwOTJiMmYwZTc4NzNlY18xLTQtMS0xLTM1NDg5_ee4b7b58-9e44-4181-914d-a67b22354f8f">The Nasdaq Global Market</ix:nonNumeric></span></td></tr></table></div><div style="margin-top:9pt;text-align:justify"><span style="color:#000000;font-family:'Arial',sans-serif;font-size:10pt;font-weight:400;line-height:120%">Check the appropriate box below if the Form 8-K filing is intended to simultaneously satisfy the filing obligation of the registrant under any of the following provisions:</span></div><div><span><br/></span></div><div style="margin-bottom:6pt;padding-left:27pt;text-indent:-27pt"><span style="color:#000000;font-family:'Arial',sans-serif;font-size:10pt;font-weight:400;line-height:125%"><ix:nonNumeric contextRef="i5cbfcea5c9f743e1bf8f224b8022bf0e_D20220228-20220228" name="dei:WrittenCommunications" format="ixt:fixed-false" id="id3VybDovL2RvY3MudjEvZG9jOmY1YmQzNjNiMGJmYzQwZWQ5ZGJkNTE4YWZiYzRmOGJlL3NlYzpmNWJkMzYzYjBiZmM0MGVkOWRiZDUxOGFmYmM0ZjhiZV8xL2ZyYWc6Nzc5MzU2MDNhNzRkNGZhZmEzMGVlM2RmNDlhZGNhZTQvdGV4dHJlZ2lvbjo3NzkzNTYwM2E3NGQ0ZmFmYTMwZWUzZGY0OWFkY2FlNF8yNjg1_f9e80665-6352-428f-82c3-46b549b0ce6c">&#9744;</ix:nonNumeric>&#160;&#160;&#160;&#160;Written communications pursuant to Rule 425 under the Securities Act (17 CFR 230.425)</span></div><div style="margin-bottom:6pt;padding-left:27pt;text-indent:-27pt"><span style="color:#000000;font-family:'Arial',sans-serif;font-size:10pt;font-weight:400;line-height:125%"><ix:nonNumeric contextRef="i5cbfcea5c9f743e1bf8f224b8022bf0e_D20220228-20220228" name="dei:SolicitingMaterial" format="ixt:fixed-false" id="id3VybDovL2RvY3MudjEvZG9jOmY1YmQzNjNiMGJmYzQwZWQ5ZGJkNTE4YWZiYzRmOGJlL3NlYzpmNWJkMzYzYjBiZmM0MGVkOWRiZDUxOGFmYmM0ZjhiZV8xL2ZyYWc6Nzc5MzU2MDNhNzRkNGZhZmEzMGVlM2RmNDlhZGNhZTQvdGV4dHJlZ2lvbjo3NzkzNTYwM2E3NGQ0ZmFmYTMwZWUzZGY0OWFkY2FlNF8yNjgx_2a7552ea-09aa-4f93-bf2c-946168b6e856">&#9744;</ix:nonNumeric>&#160;&#160;&#160;&#160;Soliciting material pursuant to Rule 14a-12 under the Exchange Act (17 CFR 240.14a-12)</span></div><div style="margin-bottom:6pt;padding-left:27pt;text-indent:-27pt"><span style="color:#000000;font-family:'Arial',sans-serif;font-size:10pt;font-weight:400;line-height:125%"><ix:nonNumeric contextRef="i5cbfcea5c9f743e1bf8f224b8022bf0e_D20220228-20220228" name="dei:PreCommencementTenderOffer" format="ixt:fixed-false" id="id3VybDovL2RvY3MudjEvZG9jOmY1YmQzNjNiMGJmYzQwZWQ5ZGJkNTE4YWZiYzRmOGJlL3NlYzpmNWJkMzYzYjBiZmM0MGVkOWRiZDUxOGFmYmM0ZjhiZV8xL2ZyYWc6Nzc5MzU2MDNhNzRkNGZhZmEzMGVlM2RmNDlhZGNhZTQvdGV4dHJlZ2lvbjo3NzkzNTYwM2E3NGQ0ZmFmYTMwZWUzZGY0OWFkY2FlNF8yNjgy_e51f4aa6-f0e4-44b6-bac7-695e7e4ddf7f">&#9744;</ix:nonNumeric>&#160;&#160;&#160;&#160;Pre-commencement communications pursuant to Rule 14d-2(b) under the Exchange Act (17 CFR 240.14d-2(b))</span></div><div style="margin-bottom:6pt;padding-left:27pt;text-align:justify;text-indent:-27pt"><span style="color:#000000;font-family:'Arial',sans-serif;font-size:10pt;font-weight:400;line-height:125%"><ix:nonNumeric contextRef="i5cbfcea5c9f743e1bf8f224b8022bf0e_D20220228-20220228" name="dei:PreCommencementIssuerTenderOffer" format="ixt:fixed-false" id="id3VybDovL2RvY3MudjEvZG9jOmY1YmQzNjNiMGJmYzQwZWQ5ZGJkNTE4YWZiYzRmOGJlL3NlYzpmNWJkMzYzYjBiZmM0MGVkOWRiZDUxOGFmYmM0ZjhiZV8xL2ZyYWc6Nzc5MzU2MDNhNzRkNGZhZmEzMGVlM2RmNDlhZGNhZTQvdGV4dHJlZ2lvbjo3NzkzNTYwM2E3NGQ0ZmFmYTMwZWUzZGY0OWFkY2FlNF8yNjgz_aacbe409-d399-4905-9494-2964ec0b52bd">&#9744;</ix:nonNumeric>&#160;&#160;&#160;&#160;Pre-commencement communications pursuant to Rule 13e-4(c) under the Exchange Act (17 CFR 240.13e-4(c))</span></div><div style="margin-top:9pt;text-align:justify"><span style="color:#000000;font-family:'Arial',sans-serif;font-size:10pt;font-weight:400;line-height:120%">Indicate by check mark whether the registrant is an emerging growth company as defined in Rule 405 of the Securities Act of 1933 (&#167;230.405 of this chapter) or Rule 12b-2 of the Securities Exchange Act of 1934 (&#167;240.12b-2 of this chapter). </span></div><div style="margin-top:9pt;text-align:justify"><span style="color:#000000;font-family:'Arial',sans-serif;font-size:10pt;font-weight:400;line-height:120%">Emerging growth company</span><span style="color:#000000;font-family:'Arial',sans-serif;font-size:9pt;font-weight:400;line-height:120%">&#160;</span><span style="color:#000000;font-family:'Arial',sans-serif;font-size:10pt;font-weight:400;line-height:120%"> <ix:nonNumeric contextRef="i5cbfcea5c9f743e1bf8f224b8022bf0e_D20220228-20220228" name="dei:EntityEmergingGrowthCompany" format="ixt-sec:boolballotbox" id="id3VybDovL2RvY3MudjEvZG9jOmY1YmQzNjNiMGJmYzQwZWQ5ZGJkNTE4YWZiYzRmOGJlL3NlYzpmNWJkMzYzYjBiZmM0MGVkOWRiZDUxOGFmYmM0ZjhiZV8xL2ZyYWc6Nzc5MzU2MDNhNzRkNGZhZmEzMGVlM2RmNDlhZGNhZTQvdGV4dHJlZ2lvbjo3NzkzNTYwM2E3NGQ0ZmFmYTMwZWUzZGY0OWFkY2FlNF8yNjg0_00ad82ed-bd28-4b55-aa23-afd2021ded4e">&#9744;</ix:nonNumeric></span></div><div style="margin-top:9pt;text-align:justify"><span style="color:#000000;font-family:'Arial',sans-serif;font-size:10pt;font-weight:400;line-height:120%">If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section&#160;13(a) of the Exchange Act.  &#9744;</span></div><div style="height:21.6pt;position:relative;width:100%"><div style="bottom:0;position:absolute;width:100%"><div><span><br/></span></div></div></div><hr style="page-break-after:always"/><div style="min-height:21.6pt;width:100%"><div><span><br/></span></div></div><div style="margin-bottom:6pt;text-align:justify"><span style="color:#000000;font-family:'Arial',sans-serif;font-size:10pt;font-weight:700;line-height:120%">Item 2.02&#160;&#160;&#160;&#160;Results of Operations and Financial Condition.</span></div><div><span><br/></span></div><div style="margin-top:7pt;text-align:justify"><span style="color:#000000;font-family:'Arial',sans-serif;font-size:10pt;font-weight:400;line-height:120%">On February 28, 2022, Zogenix, Inc. issued a press release announcing its financial results for the fourth quarter and full-year ended December 31, 2021. A copy of this press release is attached hereto as Exhibit 99.1.</span></div><div style="margin-top:13pt;text-align:justify"><span style="color:#000000;font-family:'Arial',sans-serif;font-size:10pt;font-weight:400;line-height:120%">In accordance with General Instruction B.2 of Form 8-K, the information in this Current Report on Form 8-K, including Exhibit 99.1, shall not be deemed &#8220;filed&#8221; for purposes of Section&#160;18 of the Securities Exchange Act of 1934, as amended (the &#8220;Exchange Act&#8221;), or otherwise subject to the liability of that section, nor shall it be deemed incorporated by reference in any filing under the Securities Act of 1933, as amended, or the Exchange Act, whether made before or after the date hereof, except as expressly set forth by specific reference in such filing to this Current Report on Form 8-K.</span></div><div><span style="color:#000000;font-family:'Arial',sans-serif;font-size:12pt;font-weight:400;line-height:120%">&#160;</span></div><div><span style="color:#000000;font-family:'Arial',sans-serif;font-size:10pt;font-weight:700;line-height:120%">Item 9.01&#160;&#160;&#160;&#160;Financial Statements and Exhibits.</span></div><div><span><br/></span></div><div style="margin-top:7pt"><span style="color:#000000;font-family:'Arial',sans-serif;font-size:10pt;font-style:italic;font-weight:400;line-height:120%">(d) Exhibits.</span></div><div><span style="color:#000000;font-family:'Arial',sans-serif;font-size:12pt;font-weight:400;line-height:120%">&#160;</span><table style="border-collapse:collapse;display:inline-table;margin-bottom:5pt;vertical-align:text-bottom;width:96.928%"><tr><td style="width:1.0%"></td><td style="width:7.538%"></td><td style="width:0.1%"></td><td style="width:0.1%"></td><td style="width:1.410%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:88.652%"></td><td style="width:0.1%"></td></tr><tr style="height:3pt"><td colspan="3" style="padding:0 1pt"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="3" style="padding:0 1pt"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Arial',sans-serif;font-size:10pt;font-weight:700;line-height:100%">Exhibit<br/>Number</span></td><td colspan="3" style="padding:0 1pt"></td><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Arial',sans-serif;font-size:10pt;font-weight:700;line-height:100%">Exhibit Description</span></td></tr><tr><td colspan="3" style="border-top:1pt solid #000000;padding:2px 1pt;text-align:left;vertical-align:bottom"><div><span style="color:#0000ff;font-family:'Arial',sans-serif;font-size:10pt;font-weight:400;line-height:120%;text-decoration:underline"><a style="-sec-extract:exhibit;color:#0000ff;font-family:'Arial',sans-serif;font-size:10pt;font-weight:400;line-height:120%;text-decoration:underline" href="zgnx-20211231erexx991.htm">99.1</a></span></div></td><td colspan="3" style="padding:0 1pt"></td><td colspan="3" style="border-top:1pt solid #000000;padding:2px 1pt;text-align:left;vertical-align:bottom"><div><span style="color:#0000ff;font-family:'Arial',sans-serif;font-size:10pt;font-weight:400;line-height:100%;text-decoration:underline"><a style="-sec-extract:exhibit;color:#0000ff;font-family:'Arial',sans-serif;font-size:10pt;font-weight:400;line-height:100%;text-decoration:underline" href="zgnx-20211231erexx991.htm">Press Release dated February 28, 2022</a></span></div></td></tr><tr style="height:3pt"><td colspan="3" style="padding:0 1pt"></td><td colspan="6" style="padding:0 1pt"></td></tr></table></div><div><span><br/></span></div><div style="padding-left:9pt;text-indent:4.5pt"><span><br/></span></div><div style="height:21.6pt;position:relative;width:100%"><div style="bottom:0;position:absolute;width:100%"><div><span><br/></span></div></div></div><hr style="page-break-after:always"/><div style="min-height:21.6pt;width:100%"><div><span><br/></span></div></div><div style="padding-left:4.5pt;padding-right:4.5pt;text-align:center;text-indent:4.5pt"><span style="color:#000000;font-family:'Arial',sans-serif;font-size:10pt;font-weight:700;line-height:120%">SIGNATURES</span></div><div style="margin-top:13pt;text-align:justify"><span style="color:#000000;font-family:'Arial',sans-serif;font-size:10pt;font-weight:400;line-height:120%">Pursuant to the requirements of the Securities Exchange Act of 1934, the registrant has duly caused this report to be signed on its behalf by the undersigned hereunto duly authorized. </span></div><div style="margin-top:13pt;text-align:justify"><table style="border-collapse:collapse;display:inline-table;margin-bottom:5pt;vertical-align:text-bottom;width:99.909%"><tr><td style="width:1.0%"></td><td style="width:4.439%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:41.087%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:2.877%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:47.197%"></td><td style="width:0.1%"></td></tr><tr><td colspan="3" style="padding:0 1pt"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="6" style="padding:2px 1pt;text-align:left;vertical-align:top"><span style="color:#000000;font-family:'Arial',sans-serif;font-size:10pt;font-weight:700;line-height:100%">ZOGENIX, INC.</span></td></tr><tr style="height:15pt"><td colspan="3" style="padding:0 1pt"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="3" style="padding:0 1pt"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:top"><span style="color:#000000;font-family:'Arial',sans-serif;font-size:10pt;font-weight:400;line-height:100%">Date:</span></td><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:top"><span style="color:#000000;font-family:'Arial',sans-serif;font-size:10pt;font-weight:400;line-height:100%">February 28, 2022</span></td><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:top"><span style="color:#000000;font-family:'Arial',sans-serif;font-size:10pt;font-weight:400;line-height:100%">By:</span></td><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:top"><span style="color:#000000;font-family:'Arial',sans-serif;font-size:10pt;font-weight:400;line-height:100%">/s/ Michael P. Smith</span></td></tr><tr><td colspan="3" style="padding:0 1pt"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="3" style="border-top:1pt solid #000000;padding:2px 1pt;text-align:left;vertical-align:top"><span style="color:#000000;font-family:'Arial',sans-serif;font-size:10pt;font-weight:400;line-height:100%">Micheal P. Smith</span></td></tr><tr><td colspan="3" style="padding:0 1pt"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="3" style="padding:2px 1pt 2px 5.32pt;text-align:left;text-indent:-4.32pt;vertical-align:top"><span style="color:#000000;font-family:'Arial',sans-serif;font-size:10pt;font-weight:400;line-height:120%">Executive Vice President, Chief Financial Officer and Treasurer</span></td></tr><tr><td colspan="3" style="padding:0 1pt"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:top"><span style="color:#000000;font-family:'Arial',sans-serif;font-size:10pt;font-weight:400;line-height:100%">(Principal Financial and Accounting Officer)</span></td></tr></table></div><div><span><br/></span></div><div style="height:21.6pt;position:relative;width:100%"><div style="bottom:0;position:absolute;width:100%"><div><span><br/></span></div></div></div></body></html>
[{"type": "8-K", "sequence": "1", "filename": "zgnx-20220228.htm", "description": "8-K", "secsgml_size_bytes": 38038}]
{"company-data": {"conformed-name": "ZOGENIX, INC.", "cik": "0001375151", "assigned-sic": "2834", "irs-number": "205300780", "state-of-incorporation": "DE", "fiscal-year-end": "1231"}, "filing-values": {"form-type": "8-K", "act": "34", "file-number": "001-34962", "film-number": "22683991"}, "business-address": {"street1": "5959 HORTON STREET, SUITE 500", "city": "EMERYVILLE", "state": "CA", "zip": "94608", "phone": "(510) 550-8300"}, "mail-address": {"street1": "5959 HORTON STREET, SUITE 500", "city": "EMERYVILLE", "state": "CA", "zip": "94608"}, "former-company": {"former-conformed-name": "ZOGENIX INC", "date-changed": "20060911"}}
zgnx-20220228
UNITED STATES
SECURITIES AND EXCHANGE COMMISSION
WASHINGTON, D.C. 20549
FORM
8-K
CURRENT REPORT
Pursuant to Section 13 or 15(d)
of the Securities Exchange Act of 1934
Date of Report (Date of earliest event reported):
February 28, 2022
ZOGENIX, INC.
(Exact Name of Registrant as Specified in its Charter)
Delaware
001-34962
20-5300780
(State or Other Jurisdiction
of Incorporation)
(Commission
File Number)
(IRS Employer
Identification No.)
5959 Horton Street
,
Suite 500
,
Emeryville
,
California
94608
(Address of Principal Executive Offices)
(Zip Code)
Registrant's telephone number, including area code: (
510
)
550-8300
(Former Name or Former Address, if Changed Since Last Report.)
Securities registered pursuant to Section 12(b) of the Act:
Title of each class
Trading Symbol
Name of each exchange on which registered
Common Stock, par value $0.001 per share
ZGNX
The Nasdaq Global Market
Check the appropriate box below if the Form 8-K filing is intended to simultaneously satisfy the filing obligation of the registrant under any of the following provisions:
☐
Written communications pursuant to Rule 425 under the Securities Act (17 CFR 230.425)
☐
Soliciting material pursuant to Rule 14a-12 under the Exchange Act (17 CFR 240.14a-12)
☐
Pre-commencement communications pursuant to Rule 14d-2(b) under the Exchange Act (17 CFR 240.14d-2(b))
☐
Pre-commencement communications pursuant to Rule 13e-4(c) under the Exchange Act (17 CFR 240.13e-4(c))
Indicate by check mark whether the registrant is an emerging growth company as defined in Rule 405 of the Securities Act of 1933 (§230.405 of this chapter) or Rule 12b-2 of the Securities Exchange Act of 1934 (§240.12b-2 of this chapter).
Emerging growth company
☐
If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 13(a) of the Exchange Act.  ☐
Item 2.02    Results of Operations and Financial Condition.
On February 28, 2022, Zogenix, Inc. issued a press release announcing its financial results for the fourth quarter and full-year ended December 31, 2021. A copy of this press release is attached hereto as Exhibit 99.1.
In accordance with General Instruction B.2 of Form 8-K, the information in this Current Report on Form 8-K, including Exhibit 99.1, shall not be deemed "filed" for purposes of Section 18 of the Securities Exchange Act of 1934, as amended (the "Exchange Act"), or otherwise subject to the liability of that section, nor shall it be deemed incorporated by reference in any filing under the Securities Act of 1933, as amended, or the Exchange Act, whether made before or after the date hereof, except as expressly set forth by specific reference in such filing to this Current Report on Form 8-K.
Item 9.01    Financial Statements and Exhibits.
(d) Exhibits.
Exhibit
Number
Exhibit Description
99.1
Press Release dated February 28, 2022
SIGNATURES
Pursuant to the requirements of the Securities Exchange Act of 1934, the registrant has duly caused this report to be signed on its behalf by the undersigned hereunto duly authorized.
ZOGENIX, INC.
Date:
February 28, 2022
By:
/s/ Michael P. Smith
Micheal P. Smith
Executive Vice President, Chief Financial Officer and Treasurer
(Principal Financial and Accounting Officer)