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Prepared and filed by St Ives Financial
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<p align="center"><font size="4" face="serif"><b>UNITED STATES<br>
SECURITIES AND EXCHANGE COMMISSION</b></font><br>
<font size="2" face="serif"><b>Washington, D.C.  20549</b></font></p>
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<p align="center"><font size="4" face="serif"><b>FORM 8-K</b></font></p>
<p align="center"><font size="4" face="serif"><b>CURRENT REPORT</b></font></p>
<p align="center"><font size="3" face="serif"><b>Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934</b></font></p>  <table width="100%" cellspacing="0" cellpadding="0" border="0">
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<td align="center"><font size="2" face="serif"><b>October 27, 2005</b></font></td>
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<td align="center"><font size="2" face="serif">Date of Report (Date of earliest event reported)</font></td>
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<td align="center"><font size="2" face="serif"><b><font face="serif" size="4">APPLERA CORPORATION</font></b></font></td>
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<td align="center"><font size="2" face="serif">(Exact Name of Registrant as Specified in Its Charter)</font></td>
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<td><font size="2" face="serif"><b>        Delaware</b></font></td>
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<td width="30%"><font size="2" face="serif"><b>       1-4389</b></font></td>
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<td width="30%"><font size="2" face="serif"><b>           06-1534213</b></font></td>
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<td><font size="2" face="serif">            (State or Other Jurisdiction                  of Incorporation)</font></td>
<td>&nbsp;</td>
<td><font size="2" face="serif">    (Commission          File No.)          </font></td>
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<td><font size="2" face="serif">             (IRS Employer Identification No.)</font></td>
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<td align="center"><font size="2" face="serif"><b>301 Merritt 7<br>Norwalk, Connecticut  06851</b></font></td>
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<td align="center"><font size="2" face="serif">(Address of Principal Executive Offices, Including Zip Code)</font></td>
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<td align="center"><font size="2" face="serif"><b>(203) 840-2000</b></font></td>
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<td align="center"><font size="2" face="serif">(Registrant&#8217;s telephone number, including area code)</font></td>
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<td align="center"><font size="2" face="serif"><b>N/A<br></b>(Former name or former address, if changed since last report)</font></td>
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<p align="left"><font size="2" face="serif">Check the appropriate box below if the Form 8-K filing is intended to simultaneously satisfy the filing obligation of the registrant under any of the following provisions:</font></p>
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<td align="left"><font size="2" face="serif">Written communications pursuant to Rule 425 under the Securities Act (17 CFR 230.425)</font></td>
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<td align="left"><font size="2" face="serif">Soliciting material pursuant to Rule 14a-12 under the Exchange Act (17 CFR 240.14a-12)</font></td>
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<td align="left"><font size="2" face="serif">Pre-commencement communications pursuant to Rule 14d-2(b) under the Exchange Act (17 CFR 240.14d-2(b))</font></td>
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<td align="left"><font size="2" face="serif">Pre-commencement communications pursuant to Rule 13e-4(c) under the Exchange Act (17 CFR 240.13e-4(c))</font></td>
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<p align="left"><font size="2" face="serif"><b>Item 2.02.  Results of Operations and Financial Condition.</b></font></p>
<div style="text-indent:3%">
<p align="left"><font size="2" face="serif">(a)&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; On
    October 27, 2005, Applera Corporation (&#8220;Applera&#8221;) announced financial
    results for Applera and its business units for the first quarter of its 2006
    fiscal year. Attached hereto as Exhibit 99.1 and incorporated by reference
    herein is the text of a press release issued on October 27, 2005, with respect
    to financial results for the first quarter of fiscal year 2006 of Applera
    and Applera&#8217;s Applied Biosystems Group, and attached hereto as Exhibit
    99.2 and incorporated by reference herein is the text of a press release
    issued on October 27, 2005, with respect to financial results for the first
    quarter of fiscal year 2006 of Applera and Applera&#8217;s Celera Genomics Group.  </font></p>
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<p align="left"><font size="2" face="serif"><b>Item 9.01.  Financial Statements and Exhibits.</b></font></p>

<div style="text-indent:3%">
<p align="left"><font size="2" face="serif"><b><i>(c) Exhibits.</i></b></font></p>
<p align="left"><font size="2" face="serif">The following exhibits are filed with this Report:</font></p>
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<td align="center"><font size="2" face="serif"><i>Exhibit No.</i></font></td>
<td align="left" width="2%">&nbsp;</td>
<td width="80%" align="left"><font size="2" face="serif"><i>Description</i></font></td>
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<td align="center"><font size="2" face="serif">99.1</font></td>
<td align="left">&nbsp;</td>
<td align="left"><font size="2" face="serif">Press Release issued October 27, 2005, with respect to financial results for Applera and Applera&#8217;s Applied Biosystems Group.</font></td>
<td align="left">&nbsp;</td>
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<td align="center"><font size="2" face="serif">&nbsp;</font></td>
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<td align="center"><font size="2" face="serif">99.2</font></td>
<td align="left">&nbsp;</td>
<td align="left"><font size="2" face="serif">Press Release issued October 27, 2005, with respect to financial results for Applera and Applera&#8217;s Celera Genomics Group.</font></td>
<td align="left">&nbsp;</td>
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<p align="center"><font size="2" face="serif"><b>SIGNATURES</b></font></p>

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<p align="left"><font size="2" face="serif">Pursuant to the requirements of the Securities Exchange Act of 1934, the registrant has duly caused this report to be signed on its behalf by the undersigned hereunto duly authorized.</font></p>
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<td colspan="2" align="left"><font size="2" face="serif"><b>APPLERA CORPORATION</b></font></td>
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<td align="left"><font size="2" face="serif">&nbsp;</font></td>
<td align="left"><font size="2" face="serif">By:</font></td>
<td align="left"><font size="2" face="serif">/s/ Dennis L. Winger</font></td>
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<td></td>
<td></td>
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<td align="left"><font size="2" face="serif">&nbsp;</font></td>
<td align="left"><font size="2" face="serif">&nbsp;</font></td>
<td align="left"><font size="2" face="serif">Dennis L. Winger</font></td>
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<td align="left"><font size="2" face="serif">&nbsp;</font></td>
<td align="left"><font size="2" face="serif">&nbsp;</font></td>
<td align="left"><font size="2" face="serif">Senior Vice President and</font></td>
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<td align="left"><font size="2" face="serif">Chief Financial Officer</font></td>
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<p align="left"><font size="2" face="serif">Dated: October 27, 2005</font></p>
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<p><a href="#contents"><font size="2">Back to Contents</font></a></p>
<p align="center"><font size="2" face="serif"><b>EXHIBIT INDEX</b></font></p>
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<td align="left"><font size="2" face="serif"><i>Exhibit No.</i></font></td>
<td width="90%" align="left"><font size="2" face="serif"><i>Description</i></font></td>
</tr>
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<td align="left"><font size="2" face="serif">&nbsp;</font></td>
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<td align="left"><font size="2" face="serif">99.1</font></td>
<td align="left"><font size="2" face="serif">Press Release issued October 27, 2005, with respect to financial results for Applera and Applera&#8217;s Applied Biosystems Group.</font></td>
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<td align="left"><font size="2" face="serif">&nbsp;</font></td>
<td align="left"><font size="2" face="serif">&nbsp;</font></td>
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<td align="left"><font size="2" face="serif">99.2</font></td>
<td align="left"><font size="2" face="serif">Press Release issued October 27, 2005, with respect to financial results for Applera and Applera&#8217;s Celera Genomics Group.</font></td>
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Prepared and filed by St Ives Financial
UNITED STATES
SECURITIES AND EXCHANGE COMMISSION
Washington, D.C.  20549
FORM 8-K
CURRENT REPORT
Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934
October 27, 2005
Date of Report (Date of earliest event reported)
APPLERA CORPORATION
(Exact Name of Registrant as Specified in Its Charter)
Delaware
1-4389
06-1534213
(State or Other Jurisdiction                  of Incorporation)
(Commission          File No.)
(IRS Employer Identification No.)
301 Merritt 7
Norwalk, Connecticut  06851
(Address of Principal Executive Offices, Including Zip Code)
(203) 840-2000
(Registrant's telephone number, including area code)
N/A
(Former name or former address, if changed since last report)
Check the appropriate box below if the Form 8-K filing is intended to simultaneously satisfy the filing obligation of the registrant under any of the following provisions:
Written communications pursuant to Rule 425 under the Securities Act (17 CFR 230.425)
Soliciting material pursuant to Rule 14a-12 under the Exchange Act (17 CFR 240.14a-12)
Pre-commencement communications pursuant to Rule 14d-2(b) under the Exchange Act (17 CFR 240.14d-2(b))
Pre-commencement communications pursuant to Rule 13e-4(c) under the Exchange Act (17 CFR 240.13e-4(c))
Item 2.02.  Results of Operations and Financial Condition.
(a)      On
    October 27, 2005, Applera Corporation ("Applera") announced financial
    results for Applera and its business units for the first quarter of its 2006
    fiscal year. Attached hereto as Exhibit 99.1 and incorporated by reference
    herein is the text of a press release issued on October 27, 2005, with respect
    to financial results for the first quarter of fiscal year 2006 of Applera
    and Applera's Applied Biosystems Group, and attached hereto as Exhibit
    99.2 and incorporated by reference herein is the text of a press release
    issued on October 27, 2005, with respect to financial results for the first
    quarter of fiscal year 2006 of Applera and Applera's Celera Genomics Group.
Item 9.01.  Financial Statements and Exhibits.
(c) Exhibits.
The following exhibits are filed with this Report:
Exhibit No.
Description
99.1
Press Release issued October 27, 2005, with respect to financial results for Applera and Applera's Applied Biosystems Group.
99.2
Press Release issued October 27, 2005, with respect to financial results for Applera and Applera's Celera Genomics Group.
SIGNATURES
Pursuant to the requirements of the Securities Exchange Act of 1934, the registrant has duly caused this report to be signed on its behalf by the undersigned hereunto duly authorized.
APPLERA CORPORATION
By:
/s/ Dennis L. Winger
Dennis L. Winger
Senior Vice President and
Chief Financial Officer
Dated: October 27, 2005
Back to Contents
EXHIBIT INDEX
Exhibit No.
Description
99.1
Press Release issued October 27, 2005, with respect to financial results for Applera and Applera's Applied Biosystems Group.
99.2
Press Release issued October 27, 2005, with respect to financial results for Applera and Applera's Celera Genomics Group.