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<p  align="center"><font size="5" face="Times New Roman"><b>UNITED STATES<br> SECURITIES AND EXCHANGE COMMISSION<br> </b></font>
<font size="3"><b>Washington, D.C. 20549 </b></font></p>
<p  align="center">
<font size="5" face="Times New Roman"><b>FORM 8-K </b></font></p>
<p  align="center">
<font size="3" face="Times New Roman"><b>CURRENT REPORT<br> Pursuant to
Section&nbsp;13 or 15(d) of the Securities Exchange Act of 1934 </b></font></p>
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<font size="2" face="Times New Roman"><b>October 18, 2007</b></font></p>  </td>
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<font size="2" face="Times New Roman"><b>Date of Report (Date of earliest event reported)</b></font></p>  </td>
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  <p  align="center"><font size=1 face="Times New Roman">&nbsp;</font></p> </td>
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<font size="6" face="Times New Roman"><b>NPS PHARMACEUTICALS,   INC.</b></font></p>  </td>
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<font size="1" face="Times New Roman"><b>(Exact   name of registrant as specified in its charter)</b></font></p>  </td>
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  <p align=center><font size="2" face="Times New Roman"><b>Delaware</b></font></p>  </td>
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<font size="2" face="Times New Roman"><b>0-23272</b></font></p>  </td>
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  <p  align="center"><font size=1 face="Times New Roman">&nbsp;</font></p> </td>
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<font size="2" face="Times New Roman"><b>87-0439579</b></font></p>  </td>
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<font size="1" face="Times New Roman"><b>(State or   other jurisdiction of incorporation)</b></font></p>  </td>
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  <p style="margin-left:1em; text-indent:-1em"><font size=1 face="Times New Roman">&nbsp;</font></p> </td>
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<font size="1" face="Times New Roman"><b>(Commission   File Number)</b></font></p>  </td>
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  <p  align="center"><font size=1 face="Times New Roman">&nbsp;</font></p> </td>
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<font size="1" face="Times New Roman"><b>(I.R.S.   Employer Identification Number)</b></font></p>  </td>
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<font size="2" face="Times New Roman"><b>550 Hills Drive, 3</b><b><sup>rd</sup>   Floor</b></font></p>  </td>
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<font size="2" face="Times New Roman"><b>Bedminster, NJ 07921</b></font></p>  </td>
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  <p  align="center"><font size="1" face="Times New Roman"><b>(Address   of principal executive offices)</b></font></p>  </td>
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<font size="2" face="Times New Roman"><b>(908) 450-5300</b></font></p>  </td>
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<font size="1" face="Times New Roman"><b>(Registrant&#146;s   telephone number, including area code)</b></font></p>  </td>
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<p>
<font size="2" face="Times New Roman">
Check the appropriate box below if the Form 8-K filing is intended to
simultaneously satisfy the filing obligation of the registrant under any of the
following provisions: </font></p>
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<font size="2" face="Wingdings">o</font></p>  </td>
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<font size="2" face="Times New Roman">
Written communications pursuant to Rule 425 under the Securities Act (17 CFR
230.425)</font></p> </td>
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<font size="1" face="Times New Roman">&nbsp;</font></p>  </td>
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<font size="1" face="Times New Roman">&nbsp;</font></p>  </td>
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<font size="2" face="Wingdings">o</font></p>  </td>
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<font size="2" face="Times New Roman">
Soliciting material pursuant to Rule 14a-12 under the Exchange Act (17 CFR
240.14a-12)</font></p> </td>
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<font size="1" face="Times New Roman">&nbsp;</font></p>  </td>
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<font size="1" face="Times New Roman">&nbsp;</font></p>  </td>
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<font size="2" face="Wingdings">o</font></p>  </td>
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Pre-commencement communications pursuant to Rule 14d-2(b) under the Exchange Act
(17 CFR 240.14d-2(b))</font></p> </td>
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  <p><font size="1" face="Times New Roman">&nbsp;</font></p>  </td>
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<font size="1" face="Times New Roman">&nbsp;</font></p>  </td>
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<font size="2" face="Wingdings">o</font></p>  </td>
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<font size="2" face="Times New Roman">
Pre-commencement communications pursuant to Rule 13e-4(c) under the Exchange Act
(17 CFR 240.13e-4(c))</font></p> </td>
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<PAGE>
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<p>
<font size="2" face="Times New Roman"><b>Section 8 &#151; Other Events</b></font></p>
<p>
<font size="2" face="Times New Roman"><b>Item 8.01 Other Events.</b></font></p>
<p>
<font size="2" face="Times New Roman">
On October 18, 2007, NPS Pharmaceuticals, Inc. issued a press release announcing
the expiration and final results of its cash tender offer for any and all of its
outstanding 3.0% convertible notes due 2008. A copy of the press release is
attached hereto as Exhibit 99.1 and is incorporated herein by
reference.</font></p>
<p>
<font size="2" face="Times New Roman"><b>Section 9 &#151; Financial Statements and Exhibits</b></font></p>
<p>
<font size="2" face="Times New Roman">
<b>Item 9.01 Financial Statements and Exhibits.</b></font></p>
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<font size="1" face="Times New Roman">&nbsp;</font></p>  </td>
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<font size="2" face="Times New Roman">(c) Exhibits</font></p>  </td>
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<font size="1" face="Times New Roman">&nbsp;</font></p>  </td>
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<font size="2" face="Times New Roman">99.1</font></p>  </td>
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  <p>
<font size="2" face="Times New Roman">
Press Release issued by NPS Pharmaceuticals, Inc. on October 18, 2007 relating
to the expiration and final results of the tender offer.</font></p> </td>
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</table>

<div style="page-break-before:always"></div>
<PAGE>
<br>
<p  align="center"><font size="2" face="Times New Roman"><b>SIGNATURES</b></font></p>
<p>
<font size="2" face="Times New Roman">
&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Pursuant to the
requirements of the Securities Exchange Act of 1934, the Registrant has duly
caused this report to be signed on its behalf by the undersigned hereunto duly
authorized. </font></p>
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<font size="2" face="Times New Roman">Date: October 18, 2007</font></p>  </td>
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  <p>
<font size="2" face="Times New Roman"><b>NPS   PHARMACEUTICALS, INC.</b></font></p>  </td>
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<font size="1" face="Times New Roman">&nbsp;</font></p>  </td>
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<font size="1" face="Times New Roman">&nbsp;</font></p>  </td>
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<font size="1" face="Times New Roman">&nbsp;</font></p>  </td>
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<font size="1" face="Times New Roman">&nbsp;</font></p>  </td>
  <td width="40%" valign="top">
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<font size="1" face="Times New Roman">&nbsp;</font></p>  </td>
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<font size="1" face="Times New Roman">&nbsp;</font></p>  </td>
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<font size="2" face="Times New Roman">By:</font></p>  </td>
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  <p>
<font size="2" face="Times New Roman">/s/ Gerard J. Michel</font></p>  </td>
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<font size="1" face="Times New Roman">&nbsp;</font></p>  </td>
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<font size="1" face="Times New Roman">&nbsp;</font></p>  </td>
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<font size="1" face="Times New Roman">&nbsp;</font></p>  </td>
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<font size="2" face="Times New Roman">&nbsp;</font></p> </td>
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  <p>
<font size="2" face="Times New Roman">Name:&nbsp;&nbsp;Gerard J. Michel</font></p> </td>
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<font size="1" face="Times New Roman">&nbsp;</font></p>  </td>
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<font size="2" face="Times New Roman">&nbsp;</font></p>  </td>
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  <p>
<font size="2" face="Times New Roman">Title:&nbsp;&nbsp;&nbsp;&nbsp;Chief Financial Officer</font></p> </td>
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<PAGE>
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<p  align="center"><font size="2" face="Times New Roman"><b>EXHIBIT INDEX</b></font></p>
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  <p><font size="1" face="Times New Roman"><b>Exhibit No.</b></font></p>  </td>
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  <p><font size="1" face="Times New Roman">&nbsp;</font></p>  </td>
  <td width="90%" valign="bottom">
  <p  align="center"><font size="1" face="Times New Roman"><b>Description</b></font></p>  </td>
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  <p><font size="2" face="Times New Roman">99.1</font></p>  </td>
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  <p><font size="1" face="Times New Roman">&nbsp;</font></p>  </td>
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  <p><font size="2" face="Times New Roman">
Press Release issued by NPS Pharmaceuticals, Inc. on October 18, 2007 relating
to the expiration and final results of the tender offer.</font></p> </td>
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{"company-data": {"conformed-name": "NPS PHARMACEUTICALS INC", "cik": "0000890465", "assigned-sic": "2836", "irs-number": "870439579", "state-of-incorporation": "DE", "fiscal-year-end": "1231"}, "filing-values": {"form-type": "8-K", "act": "34", "file-number": "000-23272", "film-number": "071177861"}, "business-address": {"street1": "550 HILLS DRIVE DRIVE", "city": "BEDMINSTER", "state": "NJ", "zip": "07921", "phone": "(908) 450-5300"}, "mail-address": {"street1": "550 HILLS DRIVE DRIVE", "city": "BEDMINSTER", "state": "NJ", "zip": "07921"}}
UNITED STATES
SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 8-K
CURRENT REPORT
Pursuant to
Section 13 or 15(d) of the Securities Exchange Act of 1934
October 18, 2007
Date of Report (Date of earliest event reported)
NPS PHARMACEUTICALS,   INC.
(Exact   name of registrant as specified in its charter)
Delaware
0-23272
87-0439579
(State or   other jurisdiction of incorporation)
(Commission   File Number)
(I.R.S.   Employer Identification Number)
550 Hills Drive, 3
rd
Floor
Bedminster, NJ 07921
(Address   of principal executive offices)
(908) 450-5300
(Registrant's   telephone number, including area code)
Check the appropriate box below if the Form 8-K filing is intended to
simultaneously satisfy the filing obligation of the registrant under any of the
following provisions:
o
Written communications pursuant to Rule 425 under the Securities Act (17 CFR
230.425)
o
Soliciting material pursuant to Rule 14a-12 under the Exchange Act (17 CFR
240.14a-12)
o
Pre-commencement communications pursuant to Rule 14d-2(b) under the Exchange Act
(17 CFR 240.14d-2(b))
o
Pre-commencement communications pursuant to Rule 13e-4(c) under the Exchange Act
(17 CFR 240.13e-4(c))
Section 8 — Other Events
Item 8.01 Other Events.
On October 18, 2007, NPS Pharmaceuticals, Inc. issued a press release announcing
the expiration and final results of its cash tender offer for any and all of its
outstanding 3.0% convertible notes due 2008. A copy of the press release is
attached hereto as Exhibit 99.1 and is incorporated herein by
reference.
Section 9 — Financial Statements and Exhibits
Item 9.01 Financial Statements and Exhibits.
(c) Exhibits
99.1
Press Release issued by NPS Pharmaceuticals, Inc. on October 18, 2007 relating
to the expiration and final results of the tender offer.
SIGNATURES
Pursuant to the
requirements of the Securities Exchange Act of 1934, the Registrant has duly
caused this report to be signed on its behalf by the undersigned hereunto duly
authorized.
Date: October 18, 2007
NPS   PHARMACEUTICALS, INC.
By:
/s/ Gerard J. Michel
Name:  Gerard J. Michel
Title:    Chief Financial Officer
EXHIBIT INDEX
Exhibit No.
Description
99.1
Press Release issued by NPS Pharmaceuticals, Inc. on October 18, 2007 relating
to the expiration and final results of the tender offer.