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<p style=' margin-bottom:0pt; margin-top:0pt;text-align:center;'><B><font STYLE='FONT-SIZE:16PT'>UNITED STATES </font></B></p>

<p style=' margin-bottom:0pt; margin-top:0pt;text-align:center;'><B><font STYLE='FONT-SIZE:16PT'>SECURITIES AND EXCHANGE COMMISSION </font></B></p>

<p style=' margin-bottom:0pt; margin-top:0pt;text-align:center;'><B><font STYLE='FONT-SIZE:10PT'>WASHINGTON, DC 20549 </font></B></p>


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<p style=' margin-bottom:0pt; margin-top:12pt;text-align:center;'><B><font STYLE='FONT-SIZE:16PT'>FORM 8-K </font></B></p>


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<p style=' margin-bottom:0pt; margin-top:12pt;text-align:center;'><B><font STYLE='FONT-SIZE:10PT'>CURRENT REPORT PURSUANT </font></B></p>

<p style=' margin-bottom:0pt; margin-top:0pt;text-align:center;'><B><font STYLE='FONT-SIZE:10PT'>TO SECTION 13 OR 15(D) OF THE </font></B></p>

<p style=' margin-bottom:0pt; margin-top:0pt;text-align:center;'><B><font STYLE='FONT-SIZE:10PT'>SECURITIES EXCHANGE ACT OF 1934 </font></B></p>

<p style=' margin-bottom:0pt; margin-top:12pt;text-align:center;'><b><font style='font-size:10pt'>Date of report (Date of earliest event reported) December 19, 2006 </font></b></p>


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<p style=' margin-bottom:0pt; margin-top:8pt;text-align:center;'><b><font style='font-size:18pt'>Aphton Corporation </font></b></p>

<p style=' margin-bottom:0pt; margin-top:0pt;text-align:center;'><font style='font-size:10pt'>(Exact Name of Registrant as Specified in Its Charter) </font></p>


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<p style=' margin-bottom:0pt; margin-top:12pt;text-align:center;'><b><font style='font-size:10pt'>Delaware </font></b></p>

<p style=' margin-bottom:0pt; margin-top:0pt;text-align:center;'><font style='font-size:10pt'>(State or Other Jurisdiction of Incorporation) </font></p>

<p style=' margin-bottom:0pt; margin-top:0pt;text-align:center;'><font style='font-size:10pt'>&nbsp;</font></p>

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                    <td align=center valign=top width="280"><b><font style='font-size:10pt'>000-19122</font></b><br>
<font style='font-size:10pt'>(Commission File Number)</font><br></td>
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                    <td align=center valign=top width="280"><b><font style='font-size:10pt'>95-3640931</font></b><br>
<font style='font-size:10pt'>(IRS Employer Identification No.)</font></td>
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                    <td align=center valign=top width="280"><font style='font-size:10pt'>&nbsp;</font><br></td>
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    <td align=center valign=top width="414"><b><font style='font-size:10pt'>8
      Penn Center, 1628 JFK Boulevard, Philadelphia, PA</font></b><br>
<font style='font-size:10pt'>(Address of Principal Executive Offices)</font><br></td>

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    <td align=center valign=top width="295"><b><font style='font-size:10pt'>19103</font></b><br>
<font style='font-size:10pt'>(Zip Code)</font><br>
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<p style=' margin-bottom:0pt; margin-top:12pt;text-align:center;'><b><font style='font-size:10pt'>(215) 218-4340</font></b><font style='font-size:10pt'> </font></p>

<p style=' margin-bottom:0pt; margin-top:0pt;text-align:center;'><font style='font-size:10pt'>(Registrant&#146;s Telephone Number, Including Area Code)</font><font style='font-size:7.5pt'> </font></p>


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<p style=' margin-bottom:0pt; margin-top:8pt;text-align:left;'><font style='font-size:10pt'>Check the appropriate box below if the Form 8-K filing is intended to simultaneously satisfy the filing obligation of the registrant under any of the following provisions (</font><i><font style='font-size:10pt'>see </font></i><font style='font-size:10pt'>General Instruction A.2. below): </font></p>

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<p style=' margin-left:0pt;text-indent:0pt;text-align:left;margin-top:0pt;margin-bottom:0pt;'><font style='font-size:10pt'>Written communications pursuant to Rule 425 under the Securities Act (17 CFR 230.425) </font></p> </td> </tr></table>
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<p style=' margin-left:0pt;text-indent:0pt;text-align:left;margin-top:0pt;margin-bottom:0pt;'><font style='font-size:10pt'>Soliciting material pursuant to Rule 14a-12 under the Exchange Act (17 CFR 240.14a-12) </font></p> </td> </tr></table>
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<p style=' margin-left:0pt;text-indent:0pt;text-align:left;margin-top:0pt;margin-bottom:0pt;'><font style='font-size:10pt'>Pre-commencement communications pursuant to Rule 14d-2(b) under the Exchange Act (17 CFR 240.14d-2(b)) </font></p> </td> </tr></table>
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<p style=' margin-left:0pt;text-indent:0pt;text-align:left;margin-top:0pt;margin-bottom:0pt;'><font style='font-size:10pt'>Pre-commencement communications pursuant to Rule 13e-4(c) under the Exchange Act (17 CFR 240.13e-4(c)) </font></p> </td> </tr></table>
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<p style=' margin-left:0pt;text-indent:0pt;text-align:left;margin-top:0pt;margin-bottom:0pt;'><B><font STYLE='FONT-SIZE:10PT'>ITEM 5.02</font></B></p> </td>

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<p style=' margin-left:0pt;text-indent:0pt;text-align:left;margin-top:0pt;margin-bottom:0pt;'><B><font STYLE='FONT-SIZE:10PT'>DEPARTURE OF DIRECTORS OR PRINCIPAL OFFICERS</font></B></p> </td> </tr></table>
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<p style=' margin-bottom:0pt; margin-top:8pt; text-indent:5%;text-align:left;'><font style='font-size:10pt'>On December 19, 2006, David H. Sachs, M.D., Robert S. Basso, Vincent D. Enright, Georges Hibon, and William A. Hasler resigned as directors of the Company. </font></p>


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<p style=' margin-left:0pt;text-indent:0pt;text-align:left;margin-top:0pt;margin-bottom:0pt;'><b><font style='font-size:10pt'>Item</font></b><font style='font-size:10pt'>&nbsp;</font><b><font style='font-size:10pt'>9.01</font></b></p> </td>

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<p style=' margin-left:0pt;text-indent:0pt;text-align:left;margin-top:0pt;margin-bottom:0pt;'><b><font style='font-size:10pt'>Financial Statements and Exhibits.</font></b></p> </td> </tr></table>
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<p style=' margin-left:0pt;text-indent:0pt;text-align:left;margin-top:0pt;margin-bottom:0pt;'><font style='font-size:10pt'>(c)</font></p> </td>

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<p style=' margin-left:0pt;text-indent:0pt;text-align:left;margin-top:0pt;margin-bottom:0pt;'><font style='font-size:10pt'>Exhibits </font></p> </td> </tr></table>
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      <p style=' margin-left:0pt;text-indent:0pt;text-align:left;margin-top:2pt;margin-bottom:0pt;'><b><font style='font-size:7.5pt'>Description</font></b></p>
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<p style=' margin-bottom:0pt; margin-top:16pt;text-align:center;'><B><font STYLE='FONT-SIZE:10PT'>SIGNATURES</font></B></p>

<p style=' margin-bottom:0pt; margin-top:8pt;text-align:left;'><font style='font-size:10pt'>Pursuant to the requirements of the Securities Exchange Act of 1934, the registrant has duly caused this report to be signed on its behalf by the undersigned hereunto duly authorized. </font></p>

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<p style=' margin-left:0pt;text-indent:0pt;text-align:left;margin-top:0in;margin-bottom:0pt;'><B><font STYLE='FONT-SIZE:10PT'>APHTON CORPORATION</font></B></p> </td> </tr>
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<p style=' margin-left:0pt;text-indent:0pt;text-align:left;margin-top:0in;margin-bottom:0pt;'><br> <font style='font-size:10pt'>Date: December 22, 2006</font></p> </td>

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<p style=' margin-left:0pt;text-indent:0pt;text-align:left;margin-top:0in;margin-bottom:0pt;'><font style='font-size:10pt'>&nbsp;By:</font></p> </td>

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<p style=' margin-left:0pt;text-indent:0pt;text-align:left;margin-top:0in;margin-bottom:0pt;'><br> <font style='font-size:10pt'>/s/ Patrick T. Mooney</font></p> </td> </tr>
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<p style=' margin-left:0pt;text-indent:0pt;text-align:left;margin-top:0in;margin-bottom:0pt;'><font style='font-size:10pt'>Name:</font></p> </td>

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<p style=' margin-left:0pt;text-indent:0pt;text-align:left;margin-top:0in;margin-bottom:0pt;'><font style='font-size:10pt'>Patrick T. Money, M.D.</font></p> </td> </tr>
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<p style=' margin-left:0pt;text-indent:0pt;text-align:left;margin-top:0in;margin-bottom:0pt;'><font style='font-size:10pt'>Title:</font></p> </td>

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<p style=' margin-left:0pt;text-indent:0pt;text-align:left;margin-top:0in;margin-bottom:0pt;'><font style='font-size:10pt'>President and Chief Executive Officer</font></p> </td> </tr></table>
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<p style=' margin-bottom:0pt; margin-top:0pt;text-align:left;'><font style='font-size:10pt'>&nbsp;</font></p>

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<p style=' margin-bottom:0pt; margin-top:16pt;text-align:center;'><B><font STYLE='FONT-SIZE:10PT'>EXHIBIT INDEX </font></B></p>

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Prepared and Filed by St Ives Financial
UNITED STATES
SECURITIES AND EXCHANGE COMMISSION
WASHINGTON, DC 20549
FORM 8-K
CURRENT REPORT PURSUANT
TO SECTION 13 OR 15(D) OF THE
SECURITIES EXCHANGE ACT OF 1934
Date of report (Date of earliest event reported) December 19, 2006
Aphton Corporation
(Exact Name of Registrant as Specified in Its Charter)
Delaware
(State or Other Jurisdiction of Incorporation)
000-19122
(Commission File Number)
95-3640931
(IRS Employer Identification No.)
8
      Penn Center, 1628 JFK Boulevard, Philadelphia, PA
(Address of Principal Executive Offices)
19103
(Zip Code)
(215) 218-4340
(Registrant's Telephone Number, Including Area Code)
Check the appropriate box below if the Form 8-K filing is intended to simultaneously satisfy the filing obligation of the registrant under any of the following provisions (
see
General Instruction A.2. below):
Written communications pursuant to Rule 425 under the Securities Act (17 CFR 230.425)
Soliciting material pursuant to Rule 14a-12 under the Exchange Act (17 CFR 240.14a-12)
Pre-commencement communications pursuant to Rule 14d-2(b) under the Exchange Act (17 CFR 240.14d-2(b))
Pre-commencement communications pursuant to Rule 13e-4(c) under the Exchange Act (17 CFR 240.13e-4(c))
ITEM 5.02
DEPARTURE OF DIRECTORS OR PRINCIPAL OFFICERS
On December 19, 2006, David H. Sachs, M.D., Robert S. Basso, Vincent D. Enright, Georges Hibon, and William A. Hasler resigned as directors of the Company.
Item
9.01
Financial Statements and Exhibits.
(c)
Exhibits
Number
Description
SIGNATURES
Pursuant to the requirements of the Securities Exchange Act of 1934, the registrant has duly caused this report to be signed on its behalf by the undersigned hereunto duly authorized.
APHTON CORPORATION
Date: December 22, 2006
By:
/s/ Patrick T. Mooney
Name:
Patrick T. Money, M.D.
Title:
President and Chief Executive Officer
EXHIBIT INDEX
Number
Description