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<p  align="center"><font size="5" face="Times New Roman"><b>UNITED STATES<br> SECURITIES AND EXCHANGE COMMISSION</b></font>
<font size="3"><b><br> Washington, D.C. 20549</b></font></p>
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<font size="5" face="Times New Roman"><b>FORM 8-K</b></font></p>
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<font size="3" face="Times New Roman"><b>CURRENT REPORT<br> Pursuant to Section&nbsp;13 or 15(d) of the Securities Exchange Act of 1934 </b></font></p>
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<font size="2" face="Times New Roman"><b>October 3, 2007</b></font></p>  </td>
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<font size="1" face="Times New Roman"><b>Date of   Report (Date of earliest event reported)</b></font></p>  </td>
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<font size="6" face="Times New Roman"><b>NPS   PHARMACEUTICALS, INC.</b></font></p>  </td>
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<font size="1" face="Times New Roman"><b>(Exact   name of registrant as specified in its charter)</b></font></p>  </td>
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  <p align=center><font size="2" face="Times New Roman"><b>Delaware</b></font></p>  </td>
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<font size="2" face="Times New Roman"><b>0-23272</b></font></p>  </td>
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  <p  align="center"><font size=1 face="Times New Roman">&nbsp;</font></p> </td>
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<font size="2" face="Times New Roman"><b>87-0439579</b></font></p>  </td>
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<font size="1" face="Times New Roman"><b>(State or other jurisdiction of<br>   incorporation)</b></font></p>  </td>
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<font size="1" face="Times New Roman"><b>(Commission File Number)</b></font></p>  </td>
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<font size="1" face="Times New Roman"><b>(I.R.S. Employer<br>   Identification Number)</b></font></p>  </td>
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<font size="2" face="Times New Roman"><b>550 Hills Drive, 3</b><b><sup>rd</sup></b><b> Floor</b></font></p>  </td>
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<font size="2" face="Times New Roman"><b>Bedminster, NJ 07921</b></font></p>  </td>
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<font size="2" face="Times New Roman"><b>(908) 450-5300</b></font></p>  </td>
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<font size="1" face="Times New Roman"><b>(Registrant&#146;s   telephone number, including area code)</b></font></p>  </td>
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<font size="2" face="Times New Roman">Check the appropriate box below if the Form 8-K filing is intended to simultaneously satisfy the filing obligation of the registrant under any of the following provisions: </font></p>
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<font size="2" face="Times New Roman">Written communications   pursuant to Rule 425 under the Securities Act (17 CFR 230.425)</font></p>  </td>
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<font size="2" face="Wingdings">o</font></p>  </td>
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<font size="2" face="Times New Roman">Soliciting material   pursuant to Rule 14a-12 under the Exchange Act (17 CFR 240.14a-12)</font></p>  </td>
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<font size="2" face="Times New Roman">Pre-commencement   communications pursuant to Rule 14d-2(b) under the Exchange Act (17 CFR   240.14d-2(b))</font></p>  </td>
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<font size="2" face="Wingdings">o</font></p>  </td>
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<font size="2" face="Times New Roman">Pre-commencement   communications pursuant to Rule 13e-4(c) under the Exchange Act (17 CFR   240.13e-4(c))</font></p>  </td>
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<font size="2" face="Times New Roman"><b>Item&nbsp;8.01</b></font></p>  </td>
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<font size="2" face="Times New Roman"><b>Other   Events.</b></font></p>  </td>
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<font size="2" face="Times New Roman">On October 3, 2007, NPS Pharmaceuticals, Inc. issued a press release announcing an increase in the purchase price of its outstanding 3.0% convertible notes due 2008 (the &#147;Notes&#148;) to $987.50 per $1,000.00 principal amount of the Notes, plus accrued and unpaid interest up to, but not including, the date of payment for the Notes accepted for payment, and an extension of the tender offer until midnight, New York City time, on October&nbsp;17, 2007. A copy of the press release is attached hereto as Exhibit 99.1 and is incorporated herein by reference.</font></p>
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  <p><font size="2" face="Times New Roman"><b>Item&nbsp;9.01</b></font></p>  </td>
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<font size="2" face="Times New Roman"><b>Financial   Statements and Exhibits.</b></font></p>  </td>
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<font size="2" face="Times New Roman">(d) Exhibits </font></p>
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<font size="2" face="Times New Roman">99.1</font></p>  </td>
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<font size="2" face="Times New Roman">Press Release issued by   NPS Pharmaceuticals, Inc. on October 3, 2007 relating to the increase in the   tender offer price and extension of tender offer.</font></p>  </td>
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<font size="2" face="Times New Roman"><b>SIGNATURES</b></font></p>
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<font size="2" face="Times New Roman">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Pursuant to the requirements of the Securities Exchange Act of 1934, the Registrant has duly caused this report to be signed on its behalf by the undersigned hereunto duly authorized. </font></p>
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<font size="2" face="Times New Roman">Date: October 3, 2007</font></p>  </td>
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<font size="2" face="Times New Roman"><b>NPS   PHARMACEUTICALS, INC.</b></font></p>  </td>
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<font size="1" face="Times New Roman">&nbsp;</font></p>  </td>
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<font size="1" face="Times New Roman">&nbsp;</font></p>  </td>
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<font size="2" face="Times New Roman">By:</font></p>  </td>
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<font size="2" face="Times New Roman">/s/ VAL R. ANTCZAK</font></p>  </td>
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<font size="1" face="Times New Roman">&nbsp;</font></p>  </td>
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<font size="1" face="Times New Roman">&nbsp;</font></p>  </td>
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<font size="2" face="Times New Roman">Val R. Antczak, Senior   Vice President, Legal Affairs, General Counsel and Secretary</font></p>  </td>
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<font size="2" face="Times New Roman"><b>EXHIBIT INDEX</b></font></p>
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<font size="1" face="Times New Roman"><b>Exhibit No.</b></font></p>  </td>
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<font size="1" face="Times New Roman">&nbsp;</font></p>  </td>
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<font size="1" face="Times New Roman"><b>Description</b></font></p>  </td>
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  <p><font size="2" face="Times New Roman">99.1</font></p>  </td>
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  <p><font size="1" face="Times New Roman">&nbsp;</font></p>  </td>
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  <p><font size="2" face="Times New Roman">Press Release issued by   NPS Pharmaceuticals, Inc. on October 3, 2007 relating to the increase in the   tender offer price and extension of tender offer.</font></p>  </td>
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UNITED STATES
SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 8-K
CURRENT REPORT
Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934
October 3, 2007
Date of   Report (Date of earliest event reported)
NPS   PHARMACEUTICALS, INC.
(Exact   name of registrant as specified in its charter)
Delaware
0-23272
87-0439579
(State or other jurisdiction of
incorporation)
(Commission File Number)
(I.R.S. Employer
Identification Number)
550 Hills Drive, 3
rd
Floor
Bedminster, NJ 07921
(Address   of principal executive offices)
(908) 450-5300
(Registrant's   telephone number, including area code)
Check the appropriate box below if the Form 8-K filing is intended to simultaneously satisfy the filing obligation of the registrant under any of the following provisions:
o
Written communications   pursuant to Rule 425 under the Securities Act (17 CFR 230.425)
o
Soliciting material   pursuant to Rule 14a-12 under the Exchange Act (17 CFR 240.14a-12)
o
Pre-commencement   communications pursuant to Rule 14d-2(b) under the Exchange Act (17 CFR   240.14d-2(b))
o
Pre-commencement   communications pursuant to Rule 13e-4(c) under the Exchange Act (17 CFR   240.13e-4(c))
Item 8.01
Other   Events.
On October 3, 2007, NPS Pharmaceuticals, Inc. issued a press release announcing an increase in the purchase price of its outstanding 3.0% convertible notes due 2008 (the "Notes") to $987.50 per $1,000.00 principal amount of the Notes, plus accrued and unpaid interest up to, but not including, the date of payment for the Notes accepted for payment, and an extension of the tender offer until midnight, New York City time, on October 17, 2007. A copy of the press release is attached hereto as Exhibit 99.1 and is incorporated herein by reference.
Item 9.01
Financial   Statements and Exhibits.
(d) Exhibits
99.1
Press Release issued by   NPS Pharmaceuticals, Inc. on October 3, 2007 relating to the increase in the   tender offer price and extension of tender offer.
SIGNATURES
Pursuant to the requirements of the Securities Exchange Act of 1934, the Registrant has duly caused this report to be signed on its behalf by the undersigned hereunto duly authorized.
Date: October 3, 2007
NPS   PHARMACEUTICALS, INC.
By:
/s/ VAL R. ANTCZAK
Val R. Antczak, Senior   Vice President, Legal Affairs, General Counsel and Secretary
EXHIBIT INDEX
Exhibit No.
Description
99.1
Press Release issued by   NPS Pharmaceuticals, Inc. on October 3, 2007 relating to the increase in the   tender offer price and extension of tender offer.