<?xml version="1.0" ?><!--XBRL Document Created with Wdesk from Workiva--><!--Copyright 2023 Workiva--><!--r:8bdb2329-83db-41b3-84da-18abb17a7e30,g:e2c6547c-6636-445e-8981-829911a5c7d2,d:2f229fc35657431c9275a2b76120489a--><html xmlns:ixt-sec="http://www.sec.gov/inlineXBRL/transformation/2015-08-31" xmlns:ix="http://www.xbrl.org/2013/inlineXBRL" xmlns:dei="http://xbrl.sec.gov/dei/2021" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:ixt="http://www.xbrl.org/inlineXBRL/transformation/2020-02-12" xmlns:link="http://www.xbrl.org/2003/linkbase" xmlns:xbrli="http://www.xbrl.org/2003/instance" xmlns="http://www.w3.org/1999/xhtml" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="en-US"><head><meta http-equiv="Content-Type" content="text/html"/>


<title>cstl-20230113</title></head><body><div style="display:none"><ix:header><ix:hidden><ix:nonNumeric contextRef="i8c731384cc4e4d9d81c2481e85523367_D20230113-20230113" name="dei:EntityCentralIndexKey" id="id3VybDovL2RvY3MudjEvZG9jOjJmMjI5ZmMzNTY1NzQzMWM5Mjc1YTJiNzYxMjA0ODlhL3NlYzoyZjIyOWZjMzU2NTc0MzFjOTI3NWEyYjc2MTIwNDg5YV80L2ZyYWc6ZDUwNzE3OGQyYjgxNGJhZWIzODQ1OTJhN2RmYjhhMGIvdGFibGU6YjVkODcyY2ZhODFiNGE4NzgxOWQwYjk5NzkwZmJmMDEvdGFibGVyYW5nZTpiNWQ4NzJjZmE4MWI0YTg3ODE5ZDBiOTk3OTBmYmYwMV8wLTEtMS0xLTE2MDQ0OA_695fc4af-7f03-4969-a2b5-33ff6048f67a">0001447362</ix:nonNumeric><ix:nonNumeric contextRef="i8c731384cc4e4d9d81c2481e85523367_D20230113-20230113" name="dei:AmendmentFlag" format="ixt:fixed-false" id="id3VybDovL2RvY3MudjEvZG9jOjJmMjI5ZmMzNTY1NzQzMWM5Mjc1YTJiNzYxMjA0ODlhL3NlYzoyZjIyOWZjMzU2NTc0MzFjOTI3NWEyYjc2MTIwNDg5YV80L2ZyYWc6ZDUwNzE3OGQyYjgxNGJhZWIzODQ1OTJhN2RmYjhhMGIvdGFibGU6YjVkODcyY2ZhODFiNGE4NzgxOWQwYjk5NzkwZmJmMDEvdGFibGVyYW5nZTpiNWQ4NzJjZmE4MWI0YTg3ODE5ZDBiOTk3OTBmYmYwMV8xLTEtMS0xLTE2MDQ0OA_9b78e5a2-3970-43f9-ae3c-ed623c7e0578">FALSE</ix:nonNumeric></ix:hidden><ix:references xml:lang="en-US"><link:schemaRef xlink:type="simple" xlink:href="cstl-20230113.xsd"></link:schemaRef></ix:references><ix:resources><xbrli:context id="i8c731384cc4e4d9d81c2481e85523367_D20230113-20230113"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0001447362</xbrli:identifier></xbrli:entity><xbrli:period><xbrli:startDate>2023-01-13</xbrli:startDate><xbrli:endDate>2023-01-13</xbrli:endDate></xbrli:period></xbrli:context></ix:resources></ix:header></div><div id="i2f229fc35657431c9275a2b76120489a_1"></div><div style="min-height:42.75pt;width:100%"><div><span><br/></span></div></div><div style="-sec-extract:summary;text-align:center"><table style="border-collapse:collapse;display:inline-table;margin-bottom:5pt;vertical-align:text-bottom;width:99.853%"><tr><td style="width:1.0%"></td><td style="width:98.900%"></td><td style="width:0.1%"></td></tr><tr style="height:3pt"><td colspan="3" style="border-top:3pt double #000000;padding:0 1pt"></td></tr></table></div><div style="margin-top:6pt;text-align:center"><span style="color:#000000;font-family:'Times New Roman',sans-serif;font-size:14pt;font-weight:700;line-height:120%">UNITED STATES</span></div><div style="text-align:center"><span style="color:#000000;font-family:'Times New Roman',sans-serif;font-size:14pt;font-weight:700;line-height:120%">SECURITIES AND EXCHANGE COMMISSION</span></div><div style="text-align:center"><span style="color:#000000;font-family:'Times New Roman',sans-serif;font-size:14pt;font-weight:700;line-height:120%">Washington, D.C. 20549</span></div><div><span><br/></span></div><div style="text-align:center"><span style="color:#000000;font-family:'Times New Roman',sans-serif;font-size:14pt;font-weight:700;line-height:120%">FORM <ix:nonNumeric contextRef="i8c731384cc4e4d9d81c2481e85523367_D20230113-20230113" name="dei:DocumentType" id="id3VybDovL2RvY3MudjEvZG9jOjJmMjI5ZmMzNTY1NzQzMWM5Mjc1YTJiNzYxMjA0ODlhL3NlYzoyZjIyOWZjMzU2NTc0MzFjOTI3NWEyYjc2MTIwNDg5YV8xL2ZyYWc6NzYwZDQwN2ZlZmJiNDcwZWJmZTliZDRmNDc3N2ZlZmIvdGV4dHJlZ2lvbjo3NjBkNDA3ZmVmYmI0NzBlYmZlOWJkNGY0Nzc3ZmVmYl8yNzM3_9f3999d8-a3fe-4e0e-b088-473d8e7da42b">8-K</ix:nonNumeric></span></div><div style="text-align:center"><span style="color:#000000;font-family:'Times New Roman',sans-serif;font-size:12pt;font-weight:700;line-height:120%">CURRENT REPORT</span></div><div style="text-align:center"><span style="color:#000000;font-family:'Times New Roman',sans-serif;font-size:12pt;font-weight:700;line-height:120%">Pursuant to Section 13 or 15(d)</span></div><div style="text-align:center"><span style="color:#000000;font-family:'Times New Roman',sans-serif;font-size:12pt;font-weight:700;line-height:120%">of the Securities Exchange Act of 1934</span></div><div style="text-align:center"><span><br/></span></div><div style="text-align:center"><span style="color:#000000;font-family:'Times New Roman',sans-serif;font-size:10pt;font-weight:700;line-height:120%">Date of Report (Date of earliest event reported): <ix:nonNumeric contextRef="i8c731384cc4e4d9d81c2481e85523367_D20230113-20230113" name="dei:DocumentPeriodEndDate" format="ixt:date-monthname-day-year-en" id="id3VybDovL2RvY3MudjEvZG9jOjJmMjI5ZmMzNTY1NzQzMWM5Mjc1YTJiNzYxMjA0ODlhL3NlYzoyZjIyOWZjMzU2NTc0MzFjOTI3NWEyYjc2MTIwNDg5YV8xL2ZyYWc6NzYwZDQwN2ZlZmJiNDcwZWJmZTliZDRmNDc3N2ZlZmIvdGV4dHJlZ2lvbjo3NjBkNDA3ZmVmYmI0NzBlYmZlOWJkNGY0Nzc3ZmVmYl8yMjY_f46f51be-d688-4fba-bb6d-974fca9bff47">January 13, 2023</ix:nonNumeric></span></div><div style="text-align:center"><span><br/></span></div><div style="text-align:center"><span style="color:#000000;font-family:'Times New Roman',sans-serif;font-size:18pt;font-weight:700;line-height:120%"><ix:nonNumeric contextRef="i8c731384cc4e4d9d81c2481e85523367_D20230113-20230113" name="dei:EntityRegistrantName" id="id3VybDovL2RvY3MudjEvZG9jOjJmMjI5ZmMzNTY1NzQzMWM5Mjc1YTJiNzYxMjA0ODlhL3NlYzoyZjIyOWZjMzU2NTc0MzFjOTI3NWEyYjc2MTIwNDg5YV8xL2ZyYWc6NzYwZDQwN2ZlZmJiNDcwZWJmZTliZDRmNDc3N2ZlZmIvdGV4dHJlZ2lvbjo3NjBkNDA3ZmVmYmI0NzBlYmZlOWJkNGY0Nzc3ZmVmYl8yNzM4_ac638ae0-73cc-4e18-877d-2a170f7dff95">Castle Biosciences, Inc.</ix:nonNumeric></span></div><div style="text-align:center"><span style="color:#000000;font-family:'Times New Roman',sans-serif;font-size:10pt;font-weight:700;line-height:120%">(Exact name of registrant as specified in its charter)</span><table style="border-collapse:collapse;display:inline-table;margin-bottom:5pt;vertical-align:text-bottom;width:99.853%"><tr><td style="width:1.0%"></td><td style="width:22.911%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:15.151%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:18.812%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:18.812%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:18.814%"></td><td style="width:0.1%"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Times New Roman',sans-serif;font-size:10pt;font-weight:400;line-height:100%">&#160;</span></td><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Times New Roman',sans-serif;font-size:10pt;font-weight:400;line-height:100%">&#160;</span></td><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Times New Roman',sans-serif;font-size:10pt;font-weight:400;line-height:100%">&#160;</span></td><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Times New Roman',sans-serif;font-size:10pt;font-weight:400;line-height:100%">&#160;</span></td><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Times New Roman',sans-serif;font-size:10pt;font-weight:400;line-height:100%">&#160;</span></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:center;vertical-align:bottom"><span style="color:#000000;font-family:'Times New Roman',sans-serif;font-size:10pt;font-weight:700;line-height:100%"><ix:nonNumeric contextRef="i8c731384cc4e4d9d81c2481e85523367_D20230113-20230113" name="dei:EntityIncorporationStateCountryCode" format="ixt-sec:stateprovnameen" id="id3VybDovL2RvY3MudjEvZG9jOjJmMjI5ZmMzNTY1NzQzMWM5Mjc1YTJiNzYxMjA0ODlhL3NlYzoyZjIyOWZjMzU2NTc0MzFjOTI3NWEyYjc2MTIwNDg5YV8xL2ZyYWc6NzYwZDQwN2ZlZmJiNDcwZWJmZTliZDRmNDc3N2ZlZmIvdGFibGU6MWQ3OWY4NTAwY2UwNDlmYzgwNGI1N2E2MjQ2NGVkMzQvdGFibGVyYW5nZToxZDc5Zjg1MDBjZTA0OWZjODA0YjU3YTYyNDY0ZWQzNF8xLTAtMS0xLTE2MDQ0OA_deac7f6a-af95-44a9-aefb-b0ea0c7e6633">Delaware</ix:nonNumeric></span></td><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Times New Roman',sans-serif;font-size:10pt;font-weight:400;line-height:100%">&#160;</span></td><td colspan="3" style="padding:2px 1pt;text-align:center;vertical-align:bottom"><span style="color:#000000;font-family:'Times New Roman',sans-serif;font-size:10pt;font-weight:700;line-height:100%"><ix:nonNumeric contextRef="i8c731384cc4e4d9d81c2481e85523367_D20230113-20230113" name="dei:EntityFileNumber" id="id3VybDovL2RvY3MudjEvZG9jOjJmMjI5ZmMzNTY1NzQzMWM5Mjc1YTJiNzYxMjA0ODlhL3NlYzoyZjIyOWZjMzU2NTc0MzFjOTI3NWEyYjc2MTIwNDg5YV8xL2ZyYWc6NzYwZDQwN2ZlZmJiNDcwZWJmZTliZDRmNDc3N2ZlZmIvdGFibGU6MWQ3OWY4NTAwY2UwNDlmYzgwNGI1N2E2MjQ2NGVkMzQvdGFibGVyYW5nZToxZDc5Zjg1MDBjZTA0OWZjODA0YjU3YTYyNDY0ZWQzNF8xLTItMS0xLTE2MDQ0OA_f102bc11-326f-4435-9928-eebf7fb9ed4e">001-38984</ix:nonNumeric></span></td><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Times New Roman',sans-serif;font-size:10pt;font-weight:400;line-height:100%">&#160;</span></td><td colspan="3" style="padding:2px 1pt;text-align:center;vertical-align:bottom"><span style="color:#000000;font-family:'Times New Roman',sans-serif;font-size:10pt;font-weight:700;line-height:100%"><ix:nonNumeric contextRef="i8c731384cc4e4d9d81c2481e85523367_D20230113-20230113" name="dei:EntityTaxIdentificationNumber" id="id3VybDovL2RvY3MudjEvZG9jOjJmMjI5ZmMzNTY1NzQzMWM5Mjc1YTJiNzYxMjA0ODlhL3NlYzoyZjIyOWZjMzU2NTc0MzFjOTI3NWEyYjc2MTIwNDg5YV8xL2ZyYWc6NzYwZDQwN2ZlZmJiNDcwZWJmZTliZDRmNDc3N2ZlZmIvdGFibGU6MWQ3OWY4NTAwY2UwNDlmYzgwNGI1N2E2MjQ2NGVkMzQvdGFibGVyYW5nZToxZDc5Zjg1MDBjZTA0OWZjODA0YjU3YTYyNDY0ZWQzNF8xLTQtMS0xLTE2MDQ0OA_0690f3af-4e78-43fc-a238-a7d1b8d48d39">77-0701774</ix:nonNumeric></span></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:center;vertical-align:bottom"><span style="color:#000000;font-family:'Times New Roman',sans-serif;font-size:8pt;font-weight:700;line-height:100%">(state or other jurisdiction<br/>of incorporation)</span></td><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Times New Roman',sans-serif;font-size:8pt;font-weight:700;line-height:100%">&#160;</span></td><td colspan="3" style="padding:2px 1pt;text-align:center;vertical-align:bottom"><span style="color:#000000;font-family:'Times New Roman',sans-serif;font-size:8pt;font-weight:700;line-height:100%">(Commission<br/>File Number)</span></td><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Times New Roman',sans-serif;font-size:8pt;font-weight:700;line-height:100%">&#160;</span></td><td colspan="3" style="padding:2px 1pt;text-align:center;vertical-align:bottom"><span style="color:#000000;font-family:'Times New Roman',sans-serif;font-size:8pt;font-weight:700;line-height:100%">(I.R.S. Employer<br/>Identification No.)</span></td></tr></table></div><div style="text-align:center"><table style="border-collapse:collapse;display:inline-table;margin-bottom:5pt;vertical-align:text-bottom;width:99.707%"><tr><td style="width:1.0%"></td><td style="width:10.190%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:18.401%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:18.401%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:28.665%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:18.843%"></td><td style="width:0.1%"></td></tr><tr><td colspan="3" style="padding:0 1pt"></td><td colspan="6" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><div style="text-align:center"><span style="color:#000000;font-family:'Times New Roman',sans-serif;font-size:10pt;font-weight:700;line-height:100%"><ix:nonNumeric contextRef="i8c731384cc4e4d9d81c2481e85523367_D20230113-20230113" name="dei:EntityAddressAddressLine1" id="id3VybDovL2RvY3MudjEvZG9jOjJmMjI5ZmMzNTY1NzQzMWM5Mjc1YTJiNzYxMjA0ODlhL3NlYzoyZjIyOWZjMzU2NTc0MzFjOTI3NWEyYjc2MTIwNDg5YV8xL2ZyYWc6NzYwZDQwN2ZlZmJiNDcwZWJmZTliZDRmNDc3N2ZlZmIvdGFibGU6NDE3YjU3NjExOWJjNDIxNWEyMjM4ODU2MzY1Yzc1OGMvdGFibGVyYW5nZTo0MTdiNTc2MTE5YmM0MjE1YTIyMzg4NTYzNjVjNzU4Y18wLTEtMS0xLTE2MDQ0OC90ZXh0cmVnaW9uOmVmNmQ2MDNhY2YxNDRmMzg4MDQxZDQ5ZjUwNTU2NDA4XzQ_813cccaa-8bec-468e-af54-18f967a252a0">505 S. Friendswood Drive</ix:nonNumeric>, <ix:nonNumeric contextRef="i8c731384cc4e4d9d81c2481e85523367_D20230113-20230113" name="dei:EntityAddressAddressLine2" id="id3VybDovL2RvY3MudjEvZG9jOjJmMjI5ZmMzNTY1NzQzMWM5Mjc1YTJiNzYxMjA0ODlhL3NlYzoyZjIyOWZjMzU2NTc0MzFjOTI3NWEyYjc2MTIwNDg5YV8xL2ZyYWc6NzYwZDQwN2ZlZmJiNDcwZWJmZTliZDRmNDc3N2ZlZmIvdGFibGU6NDE3YjU3NjExOWJjNDIxNWEyMjM4ODU2MzY1Yzc1OGMvdGFibGVyYW5nZTo0MTdiNTc2MTE5YmM0MjE1YTIyMzg4NTYzNjVjNzU4Y18wLTEtMS0xLTE2MDQ0OC90ZXh0cmVnaW9uOmVmNmQ2MDNhY2YxNDRmMzg4MDQxZDQ5ZjUwNTU2NDA4Xzg_c3cda656-cadc-4761-bfcd-5a56bcfc837d">Suite 401</ix:nonNumeric></span></div><div style="text-align:center"><span style="color:#000000;font-family:'Times New Roman',sans-serif;font-size:10pt;font-weight:700;line-height:100%"><ix:nonNumeric contextRef="i8c731384cc4e4d9d81c2481e85523367_D20230113-20230113" name="dei:EntityAddressCityOrTown" id="id3VybDovL2RvY3MudjEvZG9jOjJmMjI5ZmMzNTY1NzQzMWM5Mjc1YTJiNzYxMjA0ODlhL3NlYzoyZjIyOWZjMzU2NTc0MzFjOTI3NWEyYjc2MTIwNDg5YV8xL2ZyYWc6NzYwZDQwN2ZlZmJiNDcwZWJmZTliZDRmNDc3N2ZlZmIvdGFibGU6NDE3YjU3NjExOWJjNDIxNWEyMjM4ODU2MzY1Yzc1OGMvdGFibGVyYW5nZTo0MTdiNTc2MTE5YmM0MjE1YTIyMzg4NTYzNjVjNzU4Y18wLTEtMS0xLTE2MDQ0OC90ZXh0cmVnaW9uOmVmNmQ2MDNhY2YxNDRmMzg4MDQxZDQ5ZjUwNTU2NDA4XzEx_5386e465-06c4-4428-bc6a-1ed6739b1406">Friendswood</ix:nonNumeric>, <ix:nonNumeric contextRef="i8c731384cc4e4d9d81c2481e85523367_D20230113-20230113" name="dei:EntityAddressStateOrProvince" format="ixt-sec:stateprovnameen" id="id3VybDovL2RvY3MudjEvZG9jOjJmMjI5ZmMzNTY1NzQzMWM5Mjc1YTJiNzYxMjA0ODlhL3NlYzoyZjIyOWZjMzU2NTc0MzFjOTI3NWEyYjc2MTIwNDg5YV8xL2ZyYWc6NzYwZDQwN2ZlZmJiNDcwZWJmZTliZDRmNDc3N2ZlZmIvdGFibGU6NDE3YjU3NjExOWJjNDIxNWEyMjM4ODU2MzY1Yzc1OGMvdGFibGVyYW5nZTo0MTdiNTc2MTE5YmM0MjE1YTIyMzg4NTYzNjVjNzU4Y18wLTEtMS0xLTE2MDQ0OC90ZXh0cmVnaW9uOmVmNmQ2MDNhY2YxNDRmMzg4MDQxZDQ5ZjUwNTU2NDA4XzE1_90fc2df5-3932-4f30-b7de-97100fc25fb2">Texas</ix:nonNumeric></span></div></td><td colspan="3" style="padding:0 1pt"></td><td colspan="3" style="padding:2px 1pt;text-align:center;vertical-align:bottom"><span style="color:#000000;font-family:'Times New Roman',sans-serif;font-size:10pt;font-weight:700;line-height:100%"><ix:nonNumeric contextRef="i8c731384cc4e4d9d81c2481e85523367_D20230113-20230113" name="dei:EntityAddressPostalZipCode" id="id3VybDovL2RvY3MudjEvZG9jOjJmMjI5ZmMzNTY1NzQzMWM5Mjc1YTJiNzYxMjA0ODlhL3NlYzoyZjIyOWZjMzU2NTc0MzFjOTI3NWEyYjc2MTIwNDg5YV8xL2ZyYWc6NzYwZDQwN2ZlZmJiNDcwZWJmZTliZDRmNDc3N2ZlZmIvdGFibGU6NDE3YjU3NjExOWJjNDIxNWEyMjM4ODU2MzY1Yzc1OGMvdGFibGVyYW5nZTo0MTdiNTc2MTE5YmM0MjE1YTIyMzg4NTYzNjVjNzU4Y18wLTQtMS0xLTE2MDQ0OA_b09818fb-d7b6-417c-9a92-37fed8d2df77">77546</ix:nonNumeric></span></td></tr><tr><td colspan="3" style="padding:0 1pt"></td><td colspan="6" style="padding:2px 1pt;text-align:center;vertical-align:bottom"><span style="color:#000000;font-family:'Times New Roman',sans-serif;font-size:8pt;font-weight:700;line-height:100%">(Address of principal executive offices)</span></td><td colspan="3" style="padding:0 1pt"></td><td colspan="3" style="padding:2px 1pt;text-align:center;vertical-align:bottom"><span style="color:#000000;font-family:'Times New Roman',sans-serif;font-size:8pt;font-weight:700;line-height:100%">(Zip Code)</span></td></tr></table></div><div><span><br/></span></div><div style="text-align:center"><span style="color:#000000;font-family:'Times New Roman',sans-serif;font-size:10pt;font-weight:700;line-height:120%">Registrant&#8217;s telephone number, including area code: (<ix:nonNumeric contextRef="i8c731384cc4e4d9d81c2481e85523367_D20230113-20230113" name="dei:CityAreaCode" id="id3VybDovL2RvY3MudjEvZG9jOjJmMjI5ZmMzNTY1NzQzMWM5Mjc1YTJiNzYxMjA0ODlhL3NlYzoyZjIyOWZjMzU2NTc0MzFjOTI3NWEyYjc2MTIwNDg5YV8xL2ZyYWc6NzYwZDQwN2ZlZmJiNDcwZWJmZTliZDRmNDc3N2ZlZmIvdGV4dHJlZ2lvbjo3NjBkNDA3ZmVmYmI0NzBlYmZlOWJkNGY0Nzc3ZmVmYl8yNzMx_2b411ac4-2ded-48fd-b5d7-8fbaea018e59">866</ix:nonNumeric>) <ix:nonNumeric contextRef="i8c731384cc4e4d9d81c2481e85523367_D20230113-20230113" name="dei:LocalPhoneNumber" id="id3VybDovL2RvY3MudjEvZG9jOjJmMjI5ZmMzNTY1NzQzMWM5Mjc1YTJiNzYxMjA0ODlhL3NlYzoyZjIyOWZjMzU2NTc0MzFjOTI3NWEyYjc2MTIwNDg5YV8xL2ZyYWc6NzYwZDQwN2ZlZmJiNDcwZWJmZTliZDRmNDc3N2ZlZmIvdGV4dHJlZ2lvbjo3NjBkNDA3ZmVmYmI0NzBlYmZlOWJkNGY0Nzc3ZmVmYl8yNzM5_76df324f-623e-4d01-b99a-f6f09904a7dc">788-9007</ix:nonNumeric></span></div><div style="text-align:center"><span><br/></span></div><div style="text-align:center"><span style="color:#000000;font-family:'Times New Roman',sans-serif;font-size:8pt;font-weight:700;line-height:120%">(Former name or former address, if changed since last report.)</span></div><div style="text-align:center"><span><br/></span></div><div><span style="color:#000000;font-family:'Times New Roman',sans-serif;font-size:10pt;font-weight:400;line-height:120%">Check the appropriate box below if the Form 8-K filing is intended to simultaneously satisfy the filing obligation of the registrant under any of the following provisions:&#160;</span></div><div><span><br/></span></div><div style="margin-bottom:6pt"><span style="color:#000000;font-family:'Times New Roman',sans-serif;font-size:10pt;font-weight:400;line-height:120%"><ix:nonNumeric contextRef="i8c731384cc4e4d9d81c2481e85523367_D20230113-20230113" name="dei:WrittenCommunications" format="ixt-sec:boolballotbox" id="id3VybDovL2RvY3MudjEvZG9jOjJmMjI5ZmMzNTY1NzQzMWM5Mjc1YTJiNzYxMjA0ODlhL3NlYzoyZjIyOWZjMzU2NTc0MzFjOTI3NWEyYjc2MTIwNDg5YV8xL2ZyYWc6NzYwZDQwN2ZlZmJiNDcwZWJmZTliZDRmNDc3N2ZlZmIvdGV4dHJlZ2lvbjo3NjBkNDA3ZmVmYmI0NzBlYmZlOWJkNGY0Nzc3ZmVmYl8yNzMz_f4238e8b-d3a4-48e0-9ec1-2788a6e59853">&#9744;</ix:nonNumeric></span><span style="color:#000000;font-family:'Arial',sans-serif;font-size:10pt;font-weight:400;line-height:120%">&#160;&#160;&#160;&#160;</span><span style="color:#000000;font-family:'Times New Roman',sans-serif;font-size:10pt;font-weight:400;line-height:120%">Written communications pursuant to Rule 425 under the Securities Act (17 CFR 230.425)</span></div><div style="margin-bottom:6pt"><span style="color:#000000;font-family:'Times New Roman',sans-serif;font-size:10pt;font-weight:400;line-height:120%"><ix:nonNumeric contextRef="i8c731384cc4e4d9d81c2481e85523367_D20230113-20230113" name="dei:SolicitingMaterial" format="ixt-sec:boolballotbox" id="id3VybDovL2RvY3MudjEvZG9jOjJmMjI5ZmMzNTY1NzQzMWM5Mjc1YTJiNzYxMjA0ODlhL3NlYzoyZjIyOWZjMzU2NTc0MzFjOTI3NWEyYjc2MTIwNDg5YV8xL2ZyYWc6NzYwZDQwN2ZlZmJiNDcwZWJmZTliZDRmNDc3N2ZlZmIvdGV4dHJlZ2lvbjo3NjBkNDA3ZmVmYmI0NzBlYmZlOWJkNGY0Nzc3ZmVmYl8yNzQw_70332703-df6f-4828-a61a-105815f9f992">&#9744;</ix:nonNumeric>&#160;&#160;&#160;&#160;Soliciting material pursuant to Rule 14a-12 under the Exchange Act (17 CFR 240.14a-12)&#160;</span></div><div style="margin-bottom:6pt"><span style="color:#000000;font-family:'Times New Roman',sans-serif;font-size:10pt;font-weight:400;line-height:120%"><ix:nonNumeric contextRef="i8c731384cc4e4d9d81c2481e85523367_D20230113-20230113" name="dei:PreCommencementTenderOffer" format="ixt-sec:boolballotbox" id="id3VybDovL2RvY3MudjEvZG9jOjJmMjI5ZmMzNTY1NzQzMWM5Mjc1YTJiNzYxMjA0ODlhL3NlYzoyZjIyOWZjMzU2NTc0MzFjOTI3NWEyYjc2MTIwNDg5YV8xL2ZyYWc6NzYwZDQwN2ZlZmJiNDcwZWJmZTliZDRmNDc3N2ZlZmIvdGV4dHJlZ2lvbjo3NjBkNDA3ZmVmYmI0NzBlYmZlOWJkNGY0Nzc3ZmVmYl8yNzM1_e874294a-497b-4d0c-a25f-b64c0a41905d">&#9744;</ix:nonNumeric>&#160;&#160;&#160;&#160;Pre-commencement communications pursuant to Rule 14d-2(b) under the Exchange Act (17 CFR 240.14d-2(b))&#160;</span></div><div><span style="color:#000000;font-family:'Times New Roman',sans-serif;font-size:10pt;font-weight:400;line-height:120%"><ix:nonNumeric contextRef="i8c731384cc4e4d9d81c2481e85523367_D20230113-20230113" name="dei:PreCommencementIssuerTenderOffer" format="ixt-sec:boolballotbox" id="id3VybDovL2RvY3MudjEvZG9jOjJmMjI5ZmMzNTY1NzQzMWM5Mjc1YTJiNzYxMjA0ODlhL3NlYzoyZjIyOWZjMzU2NTc0MzFjOTI3NWEyYjc2MTIwNDg5YV8xL2ZyYWc6NzYwZDQwN2ZlZmJiNDcwZWJmZTliZDRmNDc3N2ZlZmIvdGV4dHJlZ2lvbjo3NjBkNDA3ZmVmYmI0NzBlYmZlOWJkNGY0Nzc3ZmVmYl8yNzI5_671a027b-de8d-499d-a62d-00f9e4c9827a">&#9744;</ix:nonNumeric>&#160;&#160;&#160;&#160;Pre-commencement communications pursuant to Rule 13e-4(c) under the Exchange Act (17 CFR 240.13e-4(c))&#160;</span></div><div><span style="color:#000000;font-family:'Times New Roman',sans-serif;font-size:10pt;font-weight:400;line-height:120%">&#160;</span></div><div><span style="color:#000000;font-family:'Times New Roman',sans-serif;font-size:10pt;font-weight:400;line-height:120%">Securities registered pursuant to Section&#160;12(b) of the Act:</span><table style="border-collapse:collapse;display:inline-table;margin-bottom:5pt;vertical-align:text-bottom;width:99.853%"><tr><td style="width:1.0%"></td><td style="width:40.334%"></td><td style="width:0.1%"></td><td style="width:0.1%"></td><td style="width:0.532%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:11.052%"></td><td style="width:0.1%"></td><td style="width:0.1%"></td><td style="width:1.703%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:42.679%"></td><td style="width:0.1%"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:center;vertical-align:bottom"><span style="color:#000000;font-family:'Times New Roman',sans-serif;font-size:8pt;font-weight:700;line-height:100%">Title of each class</span></td><td colspan="3" style="padding:0 1pt"></td><td colspan="3" style="padding:2px 1pt;text-align:center;vertical-align:bottom"><span style="color:#000000;font-family:'Times New Roman',sans-serif;font-size:8pt;font-weight:700;line-height:100%">Trading Symbol(s)</span></td><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Times New Roman',sans-serif;font-size:8pt;font-weight:400;line-height:100%">&#160;</span></td><td colspan="3" style="padding:2px 1pt;text-align:center;vertical-align:bottom"><span style="color:#000000;font-family:'Times New Roman',sans-serif;font-size:8pt;font-weight:700;line-height:100%">Name of each exchange on which registered</span></td></tr><tr><td colspan="3" style="border-top:1pt solid #000000;padding:2px 1pt;text-align:center;vertical-align:bottom"><span style="color:#000000;font-family:'Times New Roman',sans-serif;font-size:10pt;font-weight:700;line-height:100%"><ix:nonNumeric contextRef="i8c731384cc4e4d9d81c2481e85523367_D20230113-20230113" name="dei:Security12bTitle" id="id3VybDovL2RvY3MudjEvZG9jOjJmMjI5ZmMzNTY1NzQzMWM5Mjc1YTJiNzYxMjA0ODlhL3NlYzoyZjIyOWZjMzU2NTc0MzFjOTI3NWEyYjc2MTIwNDg5YV8xL2ZyYWc6NzYwZDQwN2ZlZmJiNDcwZWJmZTliZDRmNDc3N2ZlZmIvdGFibGU6NGU3NmI3MTYzZjlhNDE0Yjk4OGM5NjgxNGM5NTdkZTYvdGFibGVyYW5nZTo0ZTc2YjcxNjNmOWE0MTRiOTg4Yzk2ODE0Yzk1N2RlNl8xLTAtMS0xLTE2MDQ0OA_375ee7c3-a3cf-471b-99a6-d964e249c770">Common Stock, $0.001 par value per share</ix:nonNumeric></span></td><td colspan="3" style="padding:0 1pt"></td><td colspan="3" style="border-top:1pt solid #000000;padding:2px 1pt;text-align:center;vertical-align:bottom"><span style="color:#000000;font-family:'Times New Roman',sans-serif;font-size:10pt;font-weight:700;line-height:100%"><ix:nonNumeric contextRef="i8c731384cc4e4d9d81c2481e85523367_D20230113-20230113" name="dei:TradingSymbol" id="id3VybDovL2RvY3MudjEvZG9jOjJmMjI5ZmMzNTY1NzQzMWM5Mjc1YTJiNzYxMjA0ODlhL3NlYzoyZjIyOWZjMzU2NTc0MzFjOTI3NWEyYjc2MTIwNDg5YV8xL2ZyYWc6NzYwZDQwN2ZlZmJiNDcwZWJmZTliZDRmNDc3N2ZlZmIvdGFibGU6NGU3NmI3MTYzZjlhNDE0Yjk4OGM5NjgxNGM5NTdkZTYvdGFibGVyYW5nZTo0ZTc2YjcxNjNmOWE0MTRiOTg4Yzk2ODE0Yzk1N2RlNl8xLTItMS0xLTE2MDQ0OA_5bad67a4-e277-4cf0-90fd-b861006dbb03">CSTL</ix:nonNumeric></span></td><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Times New Roman',sans-serif;font-size:10pt;font-weight:400;line-height:100%">&#160;</span></td><td colspan="3" style="border-top:1pt solid #000000;padding:2px 1pt;text-align:center;vertical-align:bottom"><span style="color:#000000;font-family:'Times New Roman',sans-serif;font-size:10pt;font-weight:700;line-height:100%"><ix:nonNumeric contextRef="i8c731384cc4e4d9d81c2481e85523367_D20230113-20230113" name="dei:SecurityExchangeName" format="ixt-sec:exchnameen" id="id3VybDovL2RvY3MudjEvZG9jOjJmMjI5ZmMzNTY1NzQzMWM5Mjc1YTJiNzYxMjA0ODlhL3NlYzoyZjIyOWZjMzU2NTc0MzFjOTI3NWEyYjc2MTIwNDg5YV8xL2ZyYWc6NzYwZDQwN2ZlZmJiNDcwZWJmZTliZDRmNDc3N2ZlZmIvdGFibGU6NGU3NmI3MTYzZjlhNDE0Yjk4OGM5NjgxNGM5NTdkZTYvdGFibGVyYW5nZTo0ZTc2YjcxNjNmOWE0MTRiOTg4Yzk2ODE0Yzk1N2RlNl8xLTQtMS0xLTE2MDQ0OA_4a03ded2-4ac1-4757-b536-7c7f1a67a938">The Nasdaq Global Market</ix:nonNumeric></span></td></tr></table></div><div><span><br/></span></div><div style="margin-bottom:6pt"><span style="color:#000000;font-family:'Times New Roman',sans-serif;font-size:10pt;font-weight:400;line-height:120%">Indicate by check mark whether the registrant is an emerging growth company as defined in as defined in Rule 405 of the Securities Act of 1933 (&#167; 230.405 of this chapter) or Rule 12b&#8211;2 of the Securities Exchange Act of 1934 (&#167; 240.12b&#8211;2 of this chapter).</span></div><div style="margin-bottom:6pt"><span style="color:#000000;font-family:'Times New Roman',sans-serif;font-size:10pt;font-weight:400;line-height:120%">Emerging growth company&#160;<ix:nonNumeric contextRef="i8c731384cc4e4d9d81c2481e85523367_D20230113-20230113" name="dei:EntityEmergingGrowthCompany" format="ixt:fixed-false" id="id3VybDovL2RvY3MudjEvZG9jOjJmMjI5ZmMzNTY1NzQzMWM5Mjc1YTJiNzYxMjA0ODlhL3NlYzoyZjIyOWZjMzU2NTc0MzFjOTI3NWEyYjc2MTIwNDg5YV8xL2ZyYWc6NzYwZDQwN2ZlZmJiNDcwZWJmZTliZDRmNDc3N2ZlZmIvdGV4dHJlZ2lvbjo3NjBkNDA3ZmVmYmI0NzBlYmZlOWJkNGY0Nzc3ZmVmYl8yNzMw_42b333bd-3c2d-4020-bc72-3a93b0ea69f6">&#9744;</ix:nonNumeric></span></div><div style="margin-bottom:6pt;margin-top:6pt"><span style="color:#000000;font-family:'Times New Roman',sans-serif;font-size:10pt;font-weight:400;line-height:120%">If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 13(a) of the Exchange&#160;Act.&#160;&#9744;&#160;</span><table style="border-collapse:collapse;display:inline-table;margin-bottom:5pt;vertical-align:text-bottom;width:99.853%"><tr><td style="width:1.0%"></td><td style="width:98.900%"></td><td style="width:0.1%"></td></tr><tr style="height:3pt"><td colspan="3" style="border-bottom:3pt double #000000;padding:0 1pt"></td></tr></table></div><div style="height:42.75pt;position:relative;width:100%"><div style="bottom:0;position:absolute;width:100%"><div><span><br/></span></div></div></div><hr style="page-break-after:always"/><div style="min-height:42.75pt;width:100%"><div><span><br/></span></div></div><div style="margin-bottom:6pt;margin-top:6pt;text-align:center"><table style="border-collapse:collapse;display:inline-table;margin-bottom:5pt;vertical-align:text-bottom;width:99.853%"><tr><td style="width:1.0%"></td><td style="width:98.900%"></td><td style="width:0.1%"></td></tr><tr style="height:3pt"><td colspan="3" style="border-bottom:2pt solid #000000;padding:0 1pt"></td></tr></table></div><div style="margin-bottom:3pt;margin-top:6pt"><span style="color:#000000;font-family:'Times New Roman',sans-serif;font-size:10pt;font-weight:700;line-height:120%">Item 5.02&#160;&#160;&#160;&#160;Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers; Compensatory Arrangements of Certain Officers.</span></div><div style="margin-bottom:3pt;margin-top:6pt"><span style="color:#000000;font-family:'Times New Roman',sans-serif;font-size:10pt;font-weight:400;line-height:120%">On January 13, 2023, the Board of Directors (the &#8220;Board&#8221;) of Castle Biosciences, Inc. (the &#8220;Company&#8221;) adopted a Retirement Policy (the &#8220;Policy&#8221;) to provide for certain retirement and retention benefits to Eligible Employees (as defined below) upon their voluntary retirement from all employment positions with the Company after attaining the age of 60 and completing at least five years of service with the Company. An employee of the Company will be an &#8220;Eligible Employee&#8221; for purposes of the Policy if he or she: (i) holds a position at or above the Vice President level on the date of retirement or is otherwise designated as eligible by the Board, an authorized committee thereof or the Company&#8217;s Chief Executive Officer (acting in the capacity as a member of the Board), if granted such authority by the Board; (ii) executes a general waiver and release of claims in favor of the Company (the &#8220;Release&#8221;) and allows such Release to become effective in accordance with its terms; and (iii) provides written notice to the Company of their intent to retire not less than 90 days prior to the retirement date (180 days in the case of the Company&#8217;s Chief Executive Officer) and remains employed with the Company through such period.</span></div><div style="margin-bottom:3pt;margin-top:6pt"><span style="color:#000000;font-family:'Times New Roman',sans-serif;font-size:10pt;font-weight:400;line-height:120%">The Policy provides for the following retirement and retention benefits:</span></div><div style="margin-bottom:3pt;margin-top:6pt;padding-left:36pt;text-indent:-18pt"><span style="color:#000000;font-family:'Times New Roman',sans-serif;font-size:10pt;font-weight:400;line-height:120%">&#8226;</span><span style="color:#000000;font-family:'Times New Roman',sans-serif;font-size:10pt;font-style:italic;font-weight:400;line-height:120%;padding-left:14.5pt">Acceleration of time-based equity awards</span><span style="color:#000000;font-family:'Times New Roman',sans-serif;font-size:10pt;font-weight:400;line-height:120%">. An Eligible Employee will be entitled to acceleration of vesting of any then-outstanding equity awards scheduled to vest during the applicable Vesting Period (as defined below) and that otherwise would have vested based solely on such employee&#8217;s continued employment with the Company through the applicable vesting dates, effective as of the date immediately preceding the retirement date. </span></div><div style="margin-bottom:3pt;margin-top:6pt;padding-left:36pt;text-indent:-18pt"><span style="color:#000000;font-family:'Times New Roman',sans-serif;font-size:10pt;font-weight:400;line-height:120%">&#8226;</span><span style="color:#000000;font-family:'Times New Roman',sans-serif;font-size:10pt;font-style:italic;font-weight:400;line-height:120%;padding-left:14.5pt">Acceleration of performance-based equity awards</span><span style="color:#000000;font-family:'Times New Roman',sans-serif;font-size:10pt;font-weight:400;line-height:120%">. An Eligible Employee will be entitled to acceleration of vesting of the portion of any then-outstanding equity awards for which the relevant performance conditions have been achieved prior to the retirement date and that otherwise would have vested during the applicable Vesting Period based solely on such employee&#8217;s continued employment with the Company through the applicable vesting dates, effective as of the date immediately preceding the retirement date. </span></div><div style="margin-bottom:3pt;margin-top:6pt;padding-left:36pt;text-indent:-18pt"><span style="color:#000000;font-family:'Times New Roman',sans-serif;font-size:10pt;font-weight:400;line-height:120%">&#8226;</span><span style="color:#000000;font-family:'Times New Roman',sans-serif;font-size:10pt;font-style:italic;font-weight:400;line-height:120%;padding-left:14.5pt">Extended post-termination exercise period of time-based equity awards. </span><span style="color:#000000;font-family:'Times New Roman',sans-serif;font-size:10pt;font-weight:400;line-height:120%">An Eligible Employee will be entitled to exercise outstanding and vested time-based equity awards that were held as of his or her retirement date, including any time-based equity awards that vest pursuant to the accelerated vesting provisions under the Policy, for a period of 12 months following the retirement date.</span></div><div style="margin-bottom:3pt;margin-top:6pt"><span style="color:#000000;font-family:'Times New Roman',sans-serif;font-size:10pt;font-weight:400;line-height:120%">The Vesting Periods applicable to Eligible Employees under the Policy are set forth below:</span></div><div style="margin-bottom:3pt;margin-top:6pt;padding-left:36pt;text-indent:-18pt"><span style="color:#000000;font-family:'Times New Roman',sans-serif;font-size:10pt;font-weight:400;line-height:120%">&#8226;</span><span style="color:#000000;font-family:'Times New Roman',sans-serif;font-size:10pt;font-style:italic;font-weight:400;line-height:120%;padding-left:14.5pt">Chief Executive Officer</span><span style="color:#000000;font-family:'Times New Roman',sans-serif;font-size:10pt;font-weight:400;line-height:120%">: 24 months, plus an additional six months for each year of service after the age of 66.</span></div><div style="margin-bottom:3pt;margin-top:6pt;padding-left:36pt;text-indent:-18pt"><span style="color:#000000;font-family:'Times New Roman',sans-serif;font-size:10pt;font-weight:400;line-height:120%">&#8226;</span><span style="color:#000000;font-family:'Times New Roman',sans-serif;font-size:10pt;font-style:italic;font-weight:400;line-height:120%;padding-left:14.5pt">Senior Vice President and above</span><span style="color:#000000;font-family:'Times New Roman',sans-serif;font-size:10pt;font-weight:400;line-height:120%">: 18 months, plus an additional three months for each year of service after the age of 66.</span></div><div style="margin-bottom:3pt;margin-top:6pt;padding-left:36pt;text-indent:-18pt"><span style="color:#000000;font-family:'Times New Roman',sans-serif;font-size:10pt;font-weight:400;line-height:120%">&#8226;</span><span style="color:#000000;font-family:'Times New Roman',sans-serif;font-size:10pt;font-style:italic;font-weight:400;line-height:120%;padding-left:14.5pt">Vice President and below</span><span style="color:#000000;font-family:'Times New Roman',sans-serif;font-size:10pt;font-weight:400;line-height:120%">: nine months, plus an additional three months for each year of service after the age of 66.</span></div><div style="margin-bottom:3pt;margin-top:6pt"><span><br/></span></div><div style="margin-bottom:6pt;margin-top:6pt;text-align:center"><table style="border-collapse:collapse;display:inline-table;margin-bottom:5pt;vertical-align:text-bottom;width:99.853%"><tr><td style="width:1.0%"></td><td style="width:98.900%"></td><td style="width:0.1%"></td></tr><tr style="height:3pt"><td colspan="3" style="border-bottom:2pt solid #000000;padding:0 1pt"></td></tr></table></div><div style="margin-bottom:6pt;margin-top:6pt;text-align:center"><span><br/></span></div><div style="height:42.75pt;position:relative;width:100%"><div style="bottom:0;position:absolute;width:100%"><div><span><br/></span></div></div></div><hr style="page-break-after:always"/><div style="min-height:42.75pt;width:100%"><div><span><br/></span></div></div><div style="text-align:center"><table style="border-collapse:collapse;display:inline-table;margin-bottom:5pt;vertical-align:text-bottom;width:99.853%"><tr><td style="width:1.0%"></td><td style="width:98.900%"></td><td style="width:0.1%"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:center;vertical-align:top"><span style="color:#000000;font-family:'Times New Roman',sans-serif;font-size:10pt;font-weight:700;line-height:100%">SIGNATURES</span></td></tr><tr style="height:15pt"><td colspan="3" style="padding:0 1pt"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Times New Roman',sans-serif;font-size:10pt;font-weight:400;line-height:100%">Pursuant to the requirements of the Securities Exchange Act of 1934, the registrant has caused this report to be signed on its behalf by the undersigned hereunto duly authorized.<br/></span></td></tr></table></div><div style="text-align:center"><table style="border-collapse:collapse;display:inline-table;margin-bottom:5pt;vertical-align:text-bottom;width:99.707%"><tr><td style="width:1.0%"></td><td style="width:49.926%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:14.295%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:32.479%"></td><td style="width:0.1%"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="padding:0 1pt"></td><td colspan="6" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Times New Roman',sans-serif;font-size:10pt;font-weight:700;line-height:100%">CASTLE BIOSCIENCES, INC.</span></td></tr><tr style="height:15pt"><td colspan="3" style="padding:0 1pt"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="3" style="display:none"></td></tr><tr style="height:15pt"><td colspan="3" style="padding:0 1pt"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="padding:0 1pt"></td><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Times New Roman',sans-serif;font-size:10pt;font-weight:400;line-height:100%">By:</span></td><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Times New Roman',sans-serif;font-size:10pt;font-weight:400;line-height:100%">/s/ Frank Stokes</span></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="padding:0 1pt"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="3" style="border-top:1pt solid #000000;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Times New Roman',sans-serif;font-size:10pt;font-weight:400;line-height:100%">Frank Stokes</span></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="padding:0 1pt"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Times New Roman',sans-serif;font-size:10pt;font-weight:400;line-height:100%">Chief Financial Officer</span></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><div><span style="color:#000000;font-family:'Times New Roman',sans-serif;font-size:10pt;font-weight:400;line-height:100%">Date: January 20, 2023</span></div></td><td colspan="3" style="padding:0 1pt"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="3" style="display:none"></td></tr></table></div><div><span style="color:#000000;font-family:'Times New Roman',sans-serif;font-size:10pt;font-weight:400;line-height:120%">&#160;</span></div><div><span><br/></span></div><div><span><br/></span></div><div style="height:42.75pt;position:relative;width:100%"><div style="bottom:0;position:absolute;width:100%"><div><span><br/></span></div></div></div></body></html>
[{"type": "8-K", "sequence": "1", "filename": "cstl-20230113.htm", "description": "8-K", "secsgml_size_bytes": 40008}]
{"company-data": {"conformed-name": "CASTLE BIOSCIENCES INC", "cik": "0001447362", "assigned-sic": "8071", "irs-number": "770701774", "state-of-incorporation": "DE", "fiscal-year-end": "1231"}, "filing-values": {"form-type": "8-K", "act": "34", "file-number": "001-38984", "film-number": "23541045"}, "business-address": {"street1": "505 S FRIENDSWOOD DRIVE", "street2": "SUITE 401", "city": "FRIENDSWOOD", "state": "TX", "zip": "77546", "phone": "866-788-9007"}, "mail-address": {"street1": "505 S FRIENDSWOOD DRIVE", "street2": "SUITE 401", "city": "FRIENDSWOOD", "state": "TX", "zip": "77546"}}
cstl-20230113
UNITED STATES
SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM
8-K
CURRENT REPORT
Pursuant to Section 13 or 15(d)
of the Securities Exchange Act of 1934
Date of Report (Date of earliest event reported):
January 13, 2023
Castle Biosciences, Inc.
(Exact name of registrant as specified in its charter)
Delaware
001-38984
77-0701774
(state or other jurisdiction
of incorporation)
(Commission
File Number)
(I.R.S. Employer
Identification No.)
505 S. Friendswood Drive
,
Suite 401
Friendswood
,
Texas
77546
(Address of principal executive offices)
(Zip Code)
Registrant's telephone number, including area code: (
866
)
788-9007
(Former name or former address, if changed since last report.)
Check the appropriate box below if the Form 8-K filing is intended to simultaneously satisfy the filing obligation of the registrant under any of the following provisions:
☐
Written communications pursuant to Rule 425 under the Securities Act (17 CFR 230.425)
☐
Soliciting material pursuant to Rule 14a-12 under the Exchange Act (17 CFR 240.14a-12)
☐
Pre-commencement communications pursuant to Rule 14d-2(b) under the Exchange Act (17 CFR 240.14d-2(b))
☐
Pre-commencement communications pursuant to Rule 13e-4(c) under the Exchange Act (17 CFR 240.13e-4(c))
Securities registered pursuant to Section 12(b) of the Act:
Title of each class
Trading Symbol(s)
Name of each exchange on which registered
Common Stock, $0.001 par value per share
CSTL
The Nasdaq Global Market
Indicate by check mark whether the registrant is an emerging growth company as defined in as defined in Rule 405 of the Securities Act of 1933 (§ 230.405 of this chapter) or Rule 12b–2 of the Securities Exchange Act of 1934 (§ 240.12b–2 of this chapter).
Emerging growth company
☐
If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 13(a) of the Exchange Act. ☐
Item 5.02    Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers; Compensatory Arrangements of Certain Officers.
On January 13, 2023, the Board of Directors (the "Board") of Castle Biosciences, Inc. (the "Company") adopted a Retirement Policy (the "Policy") to provide for certain retirement and retention benefits to Eligible Employees (as defined below) upon their voluntary retirement from all employment positions with the Company after attaining the age of 60 and completing at least five years of service with the Company. An employee of the Company will be an "Eligible Employee" for purposes of the Policy if he or she: (i) holds a position at or above the Vice President level on the date of retirement or is otherwise designated as eligible by the Board, an authorized committee thereof or the Company's Chief Executive Officer (acting in the capacity as a member of the Board), if granted such authority by the Board; (ii) executes a general waiver and release of claims in favor of the Company (the "Release") and allows such Release to become effective in accordance with its terms; and (iii) provides written notice to the Company of their intent to retire not less than 90 days prior to the retirement date (180 days in the case of the Company's Chief Executive Officer) and remains employed with the Company through such period.
The Policy provides for the following retirement and retention benefits:
•
Acceleration of time-based equity awards
. An Eligible Employee will be entitled to acceleration of vesting of any then-outstanding equity awards scheduled to vest during the applicable Vesting Period (as defined below) and that otherwise would have vested based solely on such employee's continued employment with the Company through the applicable vesting dates, effective as of the date immediately preceding the retirement date.
•
Acceleration of performance-based equity awards
. An Eligible Employee will be entitled to acceleration of vesting of the portion of any then-outstanding equity awards for which the relevant performance conditions have been achieved prior to the retirement date and that otherwise would have vested during the applicable Vesting Period based solely on such employee's continued employment with the Company through the applicable vesting dates, effective as of the date immediately preceding the retirement date.
•
Extended post-termination exercise period of time-based equity awards.
An Eligible Employee will be entitled to exercise outstanding and vested time-based equity awards that were held as of his or her retirement date, including any time-based equity awards that vest pursuant to the accelerated vesting provisions under the Policy, for a period of 12 months following the retirement date.
The Vesting Periods applicable to Eligible Employees under the Policy are set forth below:
•
Chief Executive Officer
: 24 months, plus an additional six months for each year of service after the age of 66.
•
Senior Vice President and above
: 18 months, plus an additional three months for each year of service after the age of 66.
•
Vice President and below
: nine months, plus an additional three months for each year of service after the age of 66.
SIGNATURES
Pursuant to the requirements of the Securities Exchange Act of 1934, the registrant has caused this report to be signed on its behalf by the undersigned hereunto duly authorized.
CASTLE BIOSCIENCES, INC.
By:
/s/ Frank Stokes
Frank Stokes
Chief Financial Officer
Date: January 20, 2023