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      <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 0pt" align="center"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman"><strong>UNITED
        STATES</strong></font></div>
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        AND EXCHANGE COMMISSION</strong></font></div>
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        D.C. 20549</strong></font></div>
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        REPORT</strong></font></div>
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        to Section 13 OR 15(d) of </strong></font></div>
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        Securities Exchange Act of 1934</strong></font></div>
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      <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 0pt" align="center"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman">Date
        of
        Report (Date of earliest event reported) October 7, 2005</font></div>
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                  C</font><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman">arnegie
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        the
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        satisfy the filing obligation of the registrant under any of the following
        provisions (see General Instruction A.2. below):</font></div>
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        Written
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        Soliciting material pursuant to Rule 14a-12 under the Exchange Act (17 CFR
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        Pre-commencement communications pursuant to Rule 14d-2(b) under the Exchange
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        Pre-commencement communications pursuant to Rule 13e-4(c) under the Exchange
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      <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 36pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 0pt" align="justify"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman">The
        Registrant was advised by counsel that it had received written notice from
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        European Patent Office that Cerus Corporation (&#8220;Cerus&#8221;) has filed an opposition
        against European Patent Application Number 0790835 (&#8220;EP &#8216;835 Patent&#8221;) which was
        granted by the European Patent Office and which is assigned to The Trustees
        of
        the University of Pennsylvania and exclusively licensed to the Registrant.
        Registrant is defending against Cerus&#8217; allegations in the Opposition that the EP
&#8216;835 Patent, which claims a vaccine for inducing a tumor specific antigen
        with a
        recombinant live Listeria, is deficient because of (i) insufficient disclosure
        in the specifications of the granted claims, (ii) the inclusion of additional
        subject matter in the granted claims, and (iii) a lack of inventive steps
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        granted claims of the EP &#8216;835 Patent. The Registrant believes that Cerus&#8217;
        allegations in the opposition have no basis and it plans to vigorously defend
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        opposition is in the early stages and, as yet, the Registrant is unable to
        evaluate the merits, if any, to the opposition proceeding. If the European
        Patent Office rules that the allegations are correct in whole or in part,
        and
        such ruling is upheld on appeal, the Registrant&#8217;s patent position in Europe may
        be eroded to the degree that the claims of the patent are narrowed or not
        allowed. The likely result of this decision will be increased competition
        for
        the Registrant in the European market for recombinant live Listeria based
        vaccines. Regardless of the outcome of the opposition proceeding, the Registrant
        believes that its freedom to operate in Europe, or any other territory, for
        its
        recombinant live Listeria based vaccine products will not be diminished.
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        has
        duly caused this report to be signed on its behalf by the undersigned hereunto
        duly authorized.</font></div>
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        <table align="center" bgcolor="#ffffff" border="0" cellpadding="0" cellspacing="0" width="100%">

            <tr valign="top" bgcolor="#ffffff">
              <td width="50%"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman">&#160;</font></td>
              <td width="1%"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman">&#160;</font></td>
              <td width="49%"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman">&#160;</font></td>
            </tr>
            <tr valign="top" bgcolor="#ffffff">
              <td><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman">&#160;</font></td>
              <td colspan="2"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman">ADVAXIS,
                INC.</font></td>
            </tr>
            <tr valign="top" bgcolor="#ffffff">
              <td><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman">&#160;<br>&#160;</font></td>
              <td><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman">&#160;<br>&#160;</font></td>
              <td><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman">&#160;<br>&#160;</font></td>
            </tr>
            <tr valign="top" bgcolor="#ffffff">
              <td><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman">Date:&#160;October
                7, 2005</font></td>
              <td><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman">By:&#160;&#160;</font></td>
              <td><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman">/s/&#160;J.
                Todd Derbin</font></td>
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                <hr style="COLOR: #000000" align="left" noshade size="2" width="80%"><font size="2">Name:</font><font id="TAB2" style="COLOR: black; LETTER-SPACING: 36pt">&#160;</font><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman">J.
                Todd Derbin</font></td>
            </tr>
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              <td colspan="2"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman">&#160;</font></td>
              <td><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman">Title:<font id="TAB2" style="COLOR: black; LETTER-SPACING: 27pt" size="3">&#160;</font><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman">
                President and Chief </font></font></td>
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              <td>
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                  Officer</font></div>
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{"company-data": {"conformed-name": "Advaxis, Inc.", "cik": "0001100397", "assigned-sic": "9995", "irs-number": "841521955", "state-of-incorporation": "CO", "fiscal-year-end": "1231"}, "filing-values": {"form-type": "8-K", "act": "34", "file-number": "000-28489", "film-number": "051129694"}, "business-address": {"street1": "212 CARNEGIE CENTER", "street2": "SUITE 206", "city": "PRINCETON", "state": "NJ", "zip": "08540", "phone": "609-895-7150"}, "mail-address": {"street1": "212 CARNEGIE CENTER", "street2": "SUITE 206", "city": "PRINCETON", "state": "NJ", "zip": "08540"}, "former-company": {"former-conformed-name": "GREAT EXPECTATIONS & ASSOCIATES INC", "date-changed": "19991203"}}
UNITED
        STATES
SECURITIES
        AND EXCHANGE COMMISSION
Washington,
        D.C. 20549
FORM
        8-K
CURRENT
        REPORT
Pursuant
        to Section 13 OR 15(d) of
The
        Securities Exchange Act of 1934
Date
        of
        Report (Date of earliest event reported) October 7, 2005
Advaxis,
                  Inc.
(Exact
                  name of registrant as specified in its
                  charter)
Colorado
00028489
84
                  - 1521955
(State
                  or other jurisdiction of incorporation)
(Commission
                  File Number)
(IRS
                  Employer Identification No.)
212
                  C
arnegie
                  Center #206, Princeton, NJ
08546
(Address
                  of principal executive offices)
(Zip
                  Code)
Registrant's
        telephone number, including area code
(609
)
        497-7555
(Former
                  name or former address, if changed since last
                  report.)
Check
        the
        appropriate box below if the Form 8-K filing is intended to simultaneously
        satisfy the filing obligation of the registrant under any of the following
        provisions (see General Instruction A.2. below):
o
Written
        communications pursuant to Rule 425 under the Securities Act (17 CFR
        230.425)
o
Soliciting material pursuant to Rule 14a-12 under the Exchange Act (17 CFR
        240.14a-12)
o
Pre-commencement communications pursuant to Rule 14d-2(b) under the Exchange
        Act
        (17 CFR 240.14d-2(b))
o
Pre-commencement communications pursuant to Rule 13e-4(c) under the Exchange
        Act
        (17 CFR 240.13e-4(c))
Item
        8.01.
Other
        Events
The
        Registrant was advised by counsel that it had received written notice from
        the
        European Patent Office that Cerus Corporation ("Cerus") has filed an opposition
        against European Patent Application Number 0790835 ("EP '835 Patent") which was
        granted by the European Patent Office and which is assigned to The Trustees
        of
        the University of Pennsylvania and exclusively licensed to the Registrant.
        Registrant is defending against Cerus' allegations in the Opposition that the EP
'835 Patent, which claims a vaccine for inducing a tumor specific antigen
        with a
        recombinant live Listeria, is deficient because of (i) insufficient disclosure
        in the specifications of the granted claims, (ii) the inclusion of additional
        subject matter in the granted claims, and (iii) a lack of inventive steps
        of the
        granted claims of the EP '835 Patent. The Registrant believes that Cerus'
        allegations in the opposition have no basis and it plans to vigorously defend
        the claims.
The
        opposition is in the early stages and, as yet, the Registrant is unable to
        evaluate the merits, if any, to the opposition proceeding. If the European
        Patent Office rules that the allegations are correct in whole or in part,
        and
        such ruling is upheld on appeal, the Registrant's patent position in Europe may
        be eroded to the degree that the claims of the patent are narrowed or not
        allowed. The likely result of this decision will be increased competition
        for
        the Registrant in the European market for recombinant live Listeria based
        vaccines. Regardless of the outcome of the opposition proceeding, the Registrant
        believes that its freedom to operate in Europe, or any other territory, for
        its
        recombinant live Listeria based vaccine products will not be diminished.
2
SIGNATURE
Pursuant
        to the requirements of the Securities Exchange Act of 1934, the registrant
        has
        duly caused this report to be signed on its behalf by the undersigned hereunto
        duly authorized.
ADVAXIS,
                INC.
Date: October
                7, 2005
By:
/s/ J.
                Todd Derbin
Name:
J.
                Todd Derbin
Title:
President and Chief
Executive
                  Officer
3