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      V035445 8-K
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      STATES</strong></font></div>
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      AND EXCHANGE COMMISSION</strong></font></div>
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      D.C., 20549 </strong></font></div>
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      8-K</strong></font></div>
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    <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 0pt" align="center"><font style="DISPLAY: inline; FONT-SIZE: 12pt; FONT-FAMILY: Times New Roman"><strong>Current
      Report</strong></font></div>
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      to Section 13 or 15(d) of the Securities Exchange Act of 1934
</strong></font></div>
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    <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 0pt" align="center"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman"><strong>Date
      Of Report (Date Of Earliest Event
      Reported):&#160;&#160;2/10/2006</strong></font></div>
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    <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 0pt" align="center"><font style="DISPLAY: inline; FONT-SIZE: 24pt; FONT-FAMILY: Times New Roman"><strong>OXIS
      INTERNATIONAL, INC.</strong></font></div>
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      Name of Registrant as Specified in its Charter)</strong></font></div>
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      File Number:&#160;&#160;0-8092</strong></font></div>
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                Employer</strong></font><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman">&#160;</font></div>
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                or Organization)</strong></font><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman">&#160;</font></div>
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                No.)</strong></font><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman">&#160;</font></div>
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      N Cutter Circle Suite 317, Portland, OR 97217</strong></font></div>
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      </strong></font></div>
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      name or former address, if changed since last report) </strong></font></div>
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      the appropriate box below if the Form 8-K filing is intended to simultaneously
      satisfy the filing obligation of the registrant under any of the following
      provisions:</strong></font></div>
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      Written communications pursuant to Rule 425 under the Securities Act (17 CFR
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      Soliciting material pursuant to Rule 14a-12 under the Exchange
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      Pre-commencement communications pursuant to Rule 14d-2(b) under the Exchange
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      Pre-commencement communications pursuant to Rule 13e-4(c) under the Exchange
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    <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 0pt" align="left"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman"><strong>Item
      1.01.</strong></font><font id="TAB2" style="COLOR: black; LETTER-SPACING: 49.5pt">&#160;</font><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman"><strong>Entry
      into a Material Definitive Agreement.</strong></font></div>
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    <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 36pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 0pt" align="left"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman">On
      February 10, 2006, OXIS International, Inc. (&#8220;OXIS&#8221;) entered into a </font><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman">Standard
      Form Office Lease dated February 2, 2006 (&#8220;Lease Agreement&#8221;) with Westcore
      Peninsula Vintage, LLC. Pursuant to the Lease Agreement, OXIS will lease 4,136
      square feet of rentable office space located at 323 Vintage Park Drive, Suite
      B,
      Foster City, California 94404 (the "Property"). The Property will serve to
      accommodate the relocation and consolidation of OXIS&#8217; corporate headquarters and
      manufacturing facilities following its recent acquisition of a majority interest
      in BioCheck, Inc. </font></div>
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    <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 36pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 0pt" align="left"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman">The
      term
      of the Lease Agreement is three years commencing on April 1, 2006 and ending
      on
      March 31, 2009. The annual base rent under the Lease Agreement begins at
      $62,040.00 per year and increases incrementally to $65,818.20 by the end of
      the
      lease term. In addition to the base rent, OXIS will be responsible for its
      proportionate share of the building's operating expenses and real estate taxes
      as specified in the Lease Agreement. </font></div>
    <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 36pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 0pt" align="left"><br></div>
    <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 36pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 0pt" align="left"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman">OXIS
      has
      a renewal option to extend the Lease Agreement for one three-year period at
      the
      then-prevailing market rental value for rentable property in the same
      area.</font></div>
    <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 36pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 0pt" align="left"><br></div>
    <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 36pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 0pt" align="left"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman">The
      foregoing summary of the material terms of the Lease Agreement is qualified
      in
      its entirety by the text of the Lease Agreement attached as Exhibit 10.1 to
      this
      Current Report on Form 8-K and incorporated herein by reference. </font></div>
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    <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 0pt" align="left"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman"><strong>Item
      9.01.</strong></font><font id="TAB2" style="COLOR: black; LETTER-SPACING: 27pt">&#160;</font><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman"><strong>Financial
      Statements and Exhibits.</strong></font></div>
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    <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 36pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 0pt" align="left"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman">(c)
      Exhibits</font></div>
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    <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 36pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 0pt" align="left"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman">10.1</font><font id="TAB2" style="COLOR: black; LETTER-SPACING: 27pt">&#160;</font><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman">Standard
      Form Office Lease between OXIS International, Inc. and Westcore Peninsula
      Vintage, LLC dated February 2, 2006.</font></div>
    <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 36pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 0pt" align="left"><br></div>
    <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 0pt" align="center"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman"><strong>Signature(s)
      </strong></font></div>
    <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 0pt" align="left"><br></div>
    <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 27pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 0pt" align="left"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman">Pursuant
      to the Requirements of the Securities Exchange Act of 1934, the Registrant
      has
      duly caused this Report to be signed on its behalf by the Undersigned hereunto
      duly authorized. </font></div>
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            <td width="50%"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: ">&#160;</font></td>
            <td width="1%"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: ">&#160;</font></td>
            <td width="49%"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: ">&#160;</font></td>
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            <td><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: ">&#160;</font></td>
            <td colspan="2"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: "><strong>OXIS
              INTERNATIONAL, INC.</strong></font></td>
          </tr>
          <tr valign="top" bgcolor="#ffffff">
            <td><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: ">&#160;<br>&#160;</font></td>
            <td><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: ">&#160;<br>&#160;</font></td>
            <td><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: ">&#160;<br>&#160;</font></td>
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            <td><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: ">Dated:&#160;February
              13, 2006</font></td>
            <td><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: ">By:&#160;&#160;</font></td>
            <td><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: ">/s/&#160;MICHAEL
              D. CENTRON</font></td>
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            <td>
              <div><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: ">Name:&#160;
                Michael D. Centron</font></div>
              <div><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: ">Title:&#160;&#160;&#160;
                Chief Financial Officer</font></div>
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      Index </strong></font></div>
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                Form Office Lease between OXIS International, Inc. and Westcore Peninsula
                Vintage, LLC dated February 2,
                2006.</font></div>
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{"company-data": {"conformed-name": "OXIS INTERNATIONAL INC", "cik": "0000109657", "assigned-sic": "2834", "irs-number": "941620407", "state-of-incorporation": "DE", "fiscal-year-end": "1231"}, "filing-values": {"form-type": "8-K", "act": "34", "file-number": "000-08092", "film-number": "06603609"}, "business-address": {"street1": "6040 N CUTTER CIRCLE STE 317", "city": "PORTLAND", "state": "OR", "zip": "97217", "phone": "5032833911"}, "mail-address": {"street1": "6040 N CUTTER CIRCLE STE 317", "city": "PORTLAND", "state": "OR", "zip": "97217"}, "former-company": [{"former-conformed-name": "DDI PHARMACEUTICALS INC", "date-changed": "19920703"}, {"former-conformed-name": "DIAGNOSTIC DATA INC /DE/", "date-changed": "19850312"}]}
V035445 8-K
UNITED
      STATES
SECURITIES
      AND EXCHANGE COMMISSION
Washington
      D.C., 20549
FORM
      8-K
Current
      Report
Pursuant
      to Section 13 or 15(d) of the Securities Exchange Act of 1934
Date
      Of Report (Date Of Earliest Event
      Reported):  2/10/2006
OXIS
      INTERNATIONAL, INC.
(Exact
      Name of Registrant as Specified in its Charter)
Commission
      File Number:  0-8092
DE
94-1620407
(State
                or Other Jurisdiction of
(I.R.S.
                Employer
Incorporation
                or Organization)
Identification
                No.)
6040
      N Cutter Circle Suite 317, Portland, OR 97217
(Address
      of Principal Executive Offices, Including Zip Code)
503-283-3911
(Registrant's
      Telephone Number, Including Area Code)
(Former
      name or former address, if changed since last report)
Check
      the appropriate box below if the Form 8-K filing is intended to simultaneously
      satisfy the filing obligation of the registrant under any of the following
      provisions:
[  ]  
      Written communications pursuant to Rule 425 under the Securities Act (17 CFR
      230.425)
[  ]  
      Soliciting material pursuant to Rule 14a-12 under the Exchange
      Act(17CFR240.14a-12)
[  ]  
      Pre-commencement communications pursuant to Rule 14d-2(b) under the Exchange
      Act(17CFR240.14d-2(b))
[  ]  
      Pre-commencement communications pursuant to Rule 13e-4(c) under the Exchange
      Act(17CFR240.13e-4(c))
Item
      1.01.
Entry
      into a Material Definitive Agreement.
On
      February 10, 2006, OXIS International, Inc. ("OXIS") entered into a
Standard
      Form Office Lease dated February 2, 2006 ("Lease Agreement") with Westcore
      Peninsula Vintage, LLC. Pursuant to the Lease Agreement, OXIS will lease 4,136
      square feet of rentable office space located at 323 Vintage Park Drive, Suite
      B,
      Foster City, California 94404 (the "Property"). The Property will serve to
      accommodate the relocation and consolidation of OXIS' corporate headquarters and
      manufacturing facilities following its recent acquisition of a majority interest
      in BioCheck, Inc.
The
      term
      of the Lease Agreement is three years commencing on April 1, 2006 and ending
      on
      March 31, 2009. The annual base rent under the Lease Agreement begins at
      $62,040.00 per year and increases incrementally to $65,818.20 by the end of
      the
      lease term. In addition to the base rent, OXIS will be responsible for its
      proportionate share of the building's operating expenses and real estate taxes
      as specified in the Lease Agreement.
OXIS
      has
      a renewal option to extend the Lease Agreement for one three-year period at
      the
      then-prevailing market rental value for rentable property in the same
      area.
The
      foregoing summary of the material terms of the Lease Agreement is qualified
      in
      its entirety by the text of the Lease Agreement attached as Exhibit 10.1 to
      this
      Current Report on Form 8-K and incorporated herein by reference.
Item
      9.01.
Financial
      Statements and Exhibits.
(c)
      Exhibits
10.1
Standard
      Form Office Lease between OXIS International, Inc. and Westcore Peninsula
      Vintage, LLC dated February 2, 2006.
Signature(s)
Pursuant
      to the Requirements of the Securities Exchange Act of 1934, the Registrant
      has
      duly caused this Report to be signed on its behalf by the Undersigned hereunto
      duly authorized.
OXIS
              INTERNATIONAL, INC.
Dated: February
              13, 2006
By:
/s/ MICHAEL
              D. CENTRON
Name: 
                Michael D. Centron
Title:   
                Chief Financial Officer
Exhibit
      Index
Exhibit No.
Description
EX-10.1
Standard
                Form Office Lease between OXIS International, Inc. and Westcore Peninsula
                Vintage, LLC dated February 2,
                2006.