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    <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 0pt" align="center"><font style="DISPLAY: inline; FONT-SIZE: 12pt; FONT-FAMILY: Times New Roman"><strong>UNITED
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      AND EXCHANGE COMMISSION</strong></font></div>
    <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 0pt" align="center"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman">Washington,
      D.C. 20549</font></div>
    <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 0pt" align="center"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman">____________________
      </font></div>
    <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 0pt" align="center">&#160;</div>
    <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 0pt" align="center"><font style="DISPLAY: inline; FONT-SIZE: 16pt; FONT-FAMILY: Times New Roman"><strong>FORM
      8K</strong></font></div>
    <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 0pt" align="center"><font style="DISPLAY: inline; FONT-SIZE: 14pt; FONT-FAMILY: Times New Roman"><strong>CURRENT
      REPORT</strong></font></div>
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      to Section 13 or 15(d) of the Securities Exchange Act of 1934</font></div>
    <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 0pt" align="center">&#160;</div>
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      </font></div>
    <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 0pt" align="center">&#160;</div>
    <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 0pt" align="center"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman">Date
      of
      Report </font></div>
    <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 0pt" align="center"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman"><strong>March
      30, 2006</strong></font></div>
    <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 0pt" align="center">&#160;</div>
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    <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 0pt" align="center"><font style="DISPLAY: inline; FONT-SIZE: 24pt; FONT-FAMILY: Times New Roman"><strong>Nanobac
      Pharmaceuticals, Incorporated</strong></font></div>
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              <div style="MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt" align="center"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman"><strong>0-24696</strong></font></div>
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                Jurisdiction</font></div>
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      N. Habana Avenue, Tampa, Florida 33614</strong></font></div>
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      5.02 Departure of Directors or Principal Officers; Election of Directors;
      Appointment of Principal Officers</strong></font></div>
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    <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 0pt" align="justify"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman">Nanobac
      announces the following changes in its Board of Directors</font></div>
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    <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 0pt" align="justify"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman"><strong>New
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    <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 0pt" align="left"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman"><strong>Dr.
      Benedict S. Maniscalco, M.D. - Director of Clinical Research, Medical Director
      and member of the Board of Directors - </strong></font><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman">Dr.
      Maniscalco joined the Board of Directors on March 29, 2006. </font></div>
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    <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 0pt" align="left"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman">2001
      to
      present Dr. Maniscalco has been in the private practice of cardiology. He was
      with Tampa Heart Center in Tampa Florida in 2000 to 2001. Dr. Maniscalco was
      in
      private practice for consultive cardiology with Health Centers of Excellence,
      Inc. as Chief Executive Officer in Tampa Florida from March 1998 thorough
      January 2000. From 1976 through 1998, he was an officer and board member of
      a
      large multi specialty cardiovascular group practice. From 1979 through 1996
      he
      was co-founder of St. Joseph&#8217;s Heart Institute in Tampa, Florida and served as
      Director of Cardiac Catheterization and Director of Cardiology during his
      tenure. </font></div>
    <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 0pt" align="left"><br></div>
    <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 0pt" align="justify"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman">Over
      past
      30 years, Dr. Maniscalco has been a member of numerous local, state and national
      professional societies. He has served as President and Governor of the Florida
      Chapter of the American College of Cardiology and has been involved in numerous
      committees dealing with socioeconomic and medical policies in both the American
      College of Cardiology and the Society for Cardiac Angiography and Interventions.
      He has been a frequent lecturer at the local, state and national level, on
      both
      clinical and non-clinical matters affecting the delivery of cardiovascular
      services. </font></div>
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    <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 0pt" align="justify"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman">Dr.
      Maniscalco received his medical degree from the Duke University School of
      Medicine in 1967. He interned at Grady Memorial Hospital in Atlanta and did
      his
      junior and senior residencies at Emory University Affiliated Hospitals, followed
      by a fellowship in Cardiovascular diseases from 1973-1975. He is licensed to
      practice in both Florida and Georgia and is certified by the American Board
      of
      Internal Medicine and the American Sub-Specialty Board in Cardiovascular
      disease.</font></div>
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    <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 0pt" align="justify"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman">Dr.
      Maniscalco replaces Dr. Jan Egberts who has resigned from Nanobac
      Pharmaceuticals, Incorporated effective March 29, 2006 due to time constraints
      associated with his other business and personal interests. Dr. Egberts did
      not
      have disagreements with the Registrant. </font></div>
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        <div style="WIDTH: 100%; TEXT-ALIGN: center"><font style="DISPLAY: inline; FONT-SIZE: 8pt; FONT-FAMILY: ">2</font></div>
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    </div>
    <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 0pt" align="left"><br>&#160;</div>
    <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 0pt" align="center"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman">SIGNATURES</font></div>
    <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 0pt" align="left"><br></div>
    <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 0pt" align="left"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman">Pursuant
      to the requirements of the Securities Exchange Act of 1934, the Registrant
      has
      duly caused this report to be signed on its behalf by the undersigned thereunto
      duly authorized.</font></div>
    <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 0pt" align="center">&#160;</div>
    <div>&#160;</div>
    <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 0pt" align="left">
      <table align="center" bgcolor="#ffffff" border="0" cellpadding="0" cellspacing="0" width="100%">

          <tr valign="top" bgcolor="#ffffff">
            <td width="50%"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: ">&#160;</font></td>
            <td width="1%"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: ">&#160;</font></td>
            <td width="49%"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: ">&#160;</font></td>
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          <tr valign="top" bgcolor="#ffffff">
            <td>&#160;</td>
            <td colspan="2">&#160;<font size="2">Nanobac Pharmaceuticals,
              Incorporated</font></td>
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          <tr valign="top" bgcolor="#ffffff">
            <td><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: ">&#160;</font></td>
            <td colspan="2"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: ">(Registrant)</font></td>
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            <td>&#160;</td>
            <td colspan="2">&#160;</td>
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          <tr valign="top" bgcolor="#ffffff">
            <td><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: ">&#160;<br>&#160;</font></td>
            <td><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: ">&#160;<br>&#160;</font></td>
            <td><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: ">&#160;<br>&#160;</font></td>
          </tr>
          <tr valign="top" bgcolor="#ffffff">
            <td><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: ">Date:&#160;March
              30, 2006</font></td>
            <td><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: ">By:&#160;&#160;</font></td>
            <td><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: "><u>/s/
              John D.
              Stanton&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;
              </u></font></td>
          </tr>
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            <td colspan="2"><font style="FONT-FAMILY: " size="1">&#160;</font></td>
            <td align="left">
              <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 0pt" align="left"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman">John
                D. Stanton, Chief Executive
                Officer</font></div>
            </td>
          </tr>

      </table><br></div>
    <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 0pt" align="left">&#160;</div>
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      <div id="FTR">
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      </div>
      <div id="PN">
        <div style="WIDTH: 100%; TEXT-ALIGN: center"><font style="DISPLAY: inline; FONT-SIZE: 8pt; FONT-FAMILY: ">3</font></div>
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          <hr style="COLOR: black" noshade size="2">
        </div>
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{"company-data": {"conformed-name": "NANOBAC PHARMACEUTICALS INC", "cik": "0000925894", "assigned-sic": "8071", "irs-number": "593248917", "state-of-incorporation": "FL", "fiscal-year-end": "1231"}, "filing-values": {"form-type": "8-K", "act": "34", "file-number": "033-80612", "film-number": "06721306"}, "business-address": {"street1": "2727 W MARTIN LUTHER KING BLVD STE 850", "city": "TAMPA", "state": "FL", "zip": "33607", "phone": "8132581064X224"}, "mail-address": {"street1": "2727 W MARTIN LUTHER KING BLVD STE 850", "city": "TAMPA", "state": "FL", "zip": "33607"}, "former-company": [{"former-conformed-name": "AMERICAN ENTERPRISE CORP", "date-changed": "20021127"}, {"former-conformed-name": "AMERICAN ENTERPRISE COM CORP", "date-changed": "20000403"}, {"former-conformed-name": "NATIONAL DIAGNOSTICS INC", "date-changed": "19940622"}]}
UNITED
      STATES
SECURITIES
      AND EXCHANGE COMMISSION
Washington,
      D.C. 20549
____________________
FORM
      8K
CURRENT
      REPORT
Pursuant
      to Section 13 or 15(d) of the Securities Exchange Act of 1934
____________________
Date
      of
      Report
March
      30, 2006
_______________________
Nanobac
      Pharmaceuticals, Incorporated
(Exact
      name of registrant as specified in its charter)
Florida
0-24696
59-3248917
(State
                or Other
                Jurisdiction
(Commission
                File
(I.R.S.
                Employer
of
                Incorporation)
Number)
Identification
                Number)
4730
      N. Habana Avenue, Tampa, Florida 33614
(Address
      of Principal Executive Office) (Zip Code)
(813)
      264-2241
(Registrant's
      telephone number, including area code)
Item
      5.02 Departure of Directors or Principal Officers; Election of Directors;
      Appointment of Principal Officers
Nanobac
      announces the following changes in its Board of Directors
New
      Director
Dr.
      Benedict S. Maniscalco, M.D. - Director of Clinical Research, Medical Director
      and member of the Board of Directors -
Dr.
      Maniscalco joined the Board of Directors on March 29, 2006.
2001
      to
      present Dr. Maniscalco has been in the private practice of cardiology. He was
      with Tampa Heart Center in Tampa Florida in 2000 to 2001. Dr. Maniscalco was
      in
      private practice for consultive cardiology with Health Centers of Excellence,
      Inc. as Chief Executive Officer in Tampa Florida from March 1998 thorough
      January 2000. From 1976 through 1998, he was an officer and board member of
      a
      large multi specialty cardiovascular group practice. From 1979 through 1996
      he
      was co-founder of St. Joseph's Heart Institute in Tampa, Florida and served as
      Director of Cardiac Catheterization and Director of Cardiology during his
      tenure.
Over
      past
      30 years, Dr. Maniscalco has been a member of numerous local, state and national
      professional societies. He has served as President and Governor of the Florida
      Chapter of the American College of Cardiology and has been involved in numerous
      committees dealing with socioeconomic and medical policies in both the American
      College of Cardiology and the Society for Cardiac Angiography and Interventions.
      He has been a frequent lecturer at the local, state and national level, on
      both
      clinical and non-clinical matters affecting the delivery of cardiovascular
      services.
Dr.
      Maniscalco received his medical degree from the Duke University School of
      Medicine in 1967. He interned at Grady Memorial Hospital in Atlanta and did
      his
      junior and senior residencies at Emory University Affiliated Hospitals, followed
      by a fellowship in Cardiovascular diseases from 1973-1975. He is licensed to
      practice in both Florida and Georgia and is certified by the American Board
      of
      Internal Medicine and the American Sub-Specialty Board in Cardiovascular
      disease.
Director
      Resignation
Dr.
      Maniscalco replaces Dr. Jan Egberts who has resigned from Nanobac
      Pharmaceuticals, Incorporated effective March 29, 2006 due to time constraints
      associated with his other business and personal interests. Dr. Egberts did
      not
      have disagreements with the Registrant.
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SIGNATURES
Pursuant
      to the requirements of the Securities Exchange Act of 1934, the Registrant
      has
      duly caused this report to be signed on its behalf by the undersigned thereunto
      duly authorized.
Nanobac Pharmaceuticals,
              Incorporated
(Registrant)
Date: March
              30, 2006
By:
/s/
              John D.
              Stanton
John
                D. Stanton, Chief Executive
                Officer
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