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        STATES</strong></font></div>
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        AND EXCHANGE COMMISSION</strong></font></div>
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        D.C. 20549</strong></font></div>
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        <div>&#160;</div></div>
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        8-K</strong></font></div>
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        <div>&#160;</div></div>
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        REPORT </strong></font></div>
      <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 0pt" align="left">&#160;</div>
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        EXCHANGE ACT OF 1934 </strong></font></div>
      <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 0pt" align="left">&#160;</div>
      <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 0pt" align="center"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman"><strong>Date
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        2005</strong></font></div>
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        <div>&#160;</div></div>
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        Pharmaceuticals, Inc. </strong></font></div>
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        Name of Registrant as Specified in Charter) </strong></font></div>
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              <td align="left" valign="bottom" width="2%">&#160;</td>
              <td align="left" valign="middle" width="24%">&#160;</td>
              <td align="left" valign="bottom" width="2%">&#160;</td>
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                  No.)</strong></font></div>
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              <td align="left" valign="bottom" width="4%">&#160;</td>
              <td align="left" valign="middle" width="37%">&#160;</td>
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                  Byberry Road, Bldg. 13</strong></font></div>
                <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 0pt" align="center"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman"><strong>Huntingdon
                  Valley, Pennsylvania</strong></font></div>
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                  of Principal Executive Offices)</strong></font></div>
              </td>
              <td align="left" valign="bottom" width="4%">
                <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 0pt" align="left">&#160;</div>
              </td>
              <td valign="top" width="37%">
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                  Code)</strong></font></div>
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      <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 0pt" align="left">&#160;</div>
      <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 0pt" align="center"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman"><strong>Registrant&#8217;s
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              <td valign="bottom" width="76%">
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                  Marina Boulevard, Suite 300</strong></font></div>
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                  California 94005</strong></font></div>
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              </td>
              <td align="left" valign="bottom" width="1%">&#160;</td>
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      <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 0pt" align="center"><br></div>
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        name or Former Address, if Changed Since Last Report.)</strong></font></div>
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        the
        appropriate box below if the Form 8-K filing is intended to simultaneously
        satisfy the filing obligation of the registrant under any of the following
        provisions (see General Instruction A.2. below): </font></div>
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                  communications pursuant to Rule 425 under the Securities Act (17
                  CFR
                  230.425) </font></div>
              </td>
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              <td align="left" valign="top" width="3%">
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                  material pursuant to Rule 14a-12 under the Exchange Act (17 CFR
                  240.14a-12) </font></div>
              </td>
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                <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 0pt" align="left"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: Wingdings">&#168;</font></div>
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                  (17 CFR
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              </td>
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        <div style="WIDTH: 100%; TEXT-ALIGN: center">
        </div>
        <div>
          <hr style="MARGIN-TOP: -5px; COLOR: #000000" noshade size="1">
          <hr style="MARGIN-TOP: -13px; COLOR: #000000" noshade size="4">
        </div>
      </div>
      <div id="HDR">

      </div>
      <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 0pt" align="left">&#160;</div>
      <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 0pt" align="left"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman"><strong>Item
        1.01 </strong></font><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman"><strong>Amendment
        of a Material Definitive Agreement</strong></font></div>
      <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 0pt" align="justify"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman">On
        November 10, 2005, Cellegy Pharmaceuticals, Inc. (&#8220;Cellegy&#8221; or the &#8220;Company&#8221;)
</font><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman">announced
        </font><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman">that
        it
        has renegotiated the EU License and Distribution Agreement for its product,
        Rectogesic&#174;, with its licensee, ProStrakan Group plc. Rectogesic is a 0.4%
        topical nitroglycerin ointment indicated for the relief of pain associated
        with
        chronic anal fissures. In September 2004, the product was approved by the
        UK
        Medicines and Healthcare Products Regulatory Agency (MHRA) for sale in the
        UK.</font></div>
      <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 0pt" align="justify"><br></div>
      <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 0pt" align="justify"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman">Under
        the
        terms of the amended agreement, ProStrakan will assume responsibility for
        all
        manufacturing and other product support functions and will purchase the product
        directly from the manufacturer rather than purchasing from Cellegy under
        the
        terms of the original agreement. In return, Cellegy will receive a payment
        of $2
        million and may receive future milestone payments of up to $ 750,000 upon
        approval of the product in certain major European countries. Cellegy will
        benefit from reduced infrastructure costs by having its partner take over
        manufacturing responsibilities.</font></div>
      <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 0pt" align="justify"><br></div>
      <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 0pt" align="justify"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman">In
        December 2004, Cellegy and ProStrakan entered into an exclusive license
        agreement for the commercialization of Rectogesic</font><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman"><sup>&#174;</sup></font><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman">
        (branded
        Cellegesic&#8482; in the United States) in Europe. In May 2005, the product was
        launched in the United Kingdom, by ProStrakan. ProStrakan will be applying
        for
        further approvals of Cellegesic throughout the EU, under the Mutual Recognition
        Procedure.</font></div>
      <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 0pt" align="justify"><br></div>
      <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 36pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 0pt" align="left"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman">A
        copy of
        the Company&#8217;s press release relating to the above matters is attached hereto as
        Exhibit 99.1 and is incorporated herein by reference.</font></div>
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              <td align="left"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman">Press
                Release dated November 10, 2005</font></td>
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        has
        duly caused this report to be signed on its behalf by the undersigned hereunto
        duly authorized. </font></div>
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                PHARMACEUTICALS, INC.</strong></font></td>
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              <td><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman">Date:&#160;
                November 15, 2005</font></td>
              <td><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman">By:&#160;&#160;</font></td>
              <td><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman">/s/&#160;Robert
                J. Caso</font></td>
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              <td>
                <div><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman">Robert
                  J. Caso</font></div>
                <div><font size="2">Vice President, Finance</font></div>
                <div><font size="2">(Duly Authorized Officer)</font></div>
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UNITED
        STATES
SECURITIES
        AND EXCHANGE COMMISSION
Washington,
        D.C. 20549
FORM
        8-K
CURRENT
        REPORT
PURSUANT
        TO SECTION 13 OR 15(d) OF THE
SECURITIES
        EXCHANGE ACT OF 1934
Date
        of report (Date of earliest event reported): November 10,
        2005
Cellegy
        Pharmaceuticals, Inc.
(Exact
        Name of Registrant as Specified in Charter)
Delaware
0-26372
82-0429727
(State
                  or other jurisdiction
of
                  incorporation)
(Commission
                  File Number)
(IRS
                  Employer
Identification
                  No.)
1800
                  Byberry Road, Bldg. 13
Huntingdon
                  Valley, Pennsylvania
19006
(Address
                  of Principal Executive Offices)
(Zip
                  Code)
Registrant's
        telephone number, including area code: (215) 914-0900
1000
                  Marina Boulevard, Suite 300
Brisbane,
                  California 94005
(Former
        name or Former Address, if Changed Since Last Report.)
Check
        the
        appropriate box below if the Form 8-K filing is intended to simultaneously
        satisfy the filing obligation of the registrant under any of the following
        provisions (see General Instruction A.2. below):
¨
Written
                  communications pursuant to Rule 425 under the Securities Act (17
                  CFR
                  230.425)
¨
Soliciting
                  material pursuant to Rule 14a-12 under the Exchange Act (17 CFR
                  240.14a-12)
¨
Pre-commencement
                  communications pursuant to Rule 14d-2(b) under the Exchange Act
                  (17 CFR
                  240.14d-2(b))
¨
Pre-commencement
                  communications pursuant to Rule 13e-4(c) under the Exchange Act
                  (17 CFR
                  240.13e-4(c))
Item
        1.01
Amendment
        of a Material Definitive Agreement
On
        November 10, 2005, Cellegy Pharmaceuticals, Inc. ("Cellegy" or the "Company")
announced
that
        it
        has renegotiated the EU License and Distribution Agreement for its product,
        Rectogesic®, with its licensee, ProStrakan Group plc. Rectogesic is a 0.4%
        topical nitroglycerin ointment indicated for the relief of pain associated
        with
        chronic anal fissures. In September 2004, the product was approved by the
        UK
        Medicines and Healthcare Products Regulatory Agency (MHRA) for sale in the
        UK.
Under
        the
        terms of the amended agreement, ProStrakan will assume responsibility for
        all
        manufacturing and other product support functions and will purchase the product
        directly from the manufacturer rather than purchasing from Cellegy under
        the
        terms of the original agreement. In return, Cellegy will receive a payment
        of $2
        million and may receive future milestone payments of up to $ 750,000 upon
        approval of the product in certain major European countries. Cellegy will
        benefit from reduced infrastructure costs by having its partner take over
        manufacturing responsibilities.
In
        December 2004, Cellegy and ProStrakan entered into an exclusive license
        agreement for the commercialization of Rectogesic
®
(branded
        Cellegesic™ in the United States) in Europe. In May 2005, the product was
        launched in the United Kingdom, by ProStrakan. ProStrakan will be applying
        for
        further approvals of Cellegesic throughout the EU, under the Mutual Recognition
        Procedure.
A
        copy of
        the Company's press release relating to the above matters is attached hereto as
        Exhibit 99.1 and is incorporated herein by reference.
Item
        9.01 Financial Statements and Exhibits
Exhibit
                List
Description
                  of Exhibit
Exhibit 99.1
Press
                Release dated November 10, 2005
SIGNATURE
Pursuant
        to the requirements of the Securities Exchange Act of 1934, the registrant
        has
        duly caused this report to be signed on its behalf by the undersigned hereunto
        duly authorized.
CELLEGY
                PHARMACEUTICALS, INC.
Date: 
                November 15, 2005
By:
/s/ Robert
                J. Caso
Robert
                  J. Caso
Vice President, Finance
(Duly Authorized Officer)