UNITED STATES
                       SECURITIES AND EXCHANGE COMMISSION
                             WASHINGTON, D.C. 20549

                                    FORM 8-K

                                 CURRENT REPORT

                     Pursuant to Section 13 or 15(d) of the
                         Securities Exchange Act of 1934

                          Date of Report: March 6, 2006
                        (Date of earliest event reported)

                          21ST CENTURY HOLDING COMPANY
                          ----------------------------
             (Exact name of registrant as specified in its charter)

         Florida                         0-2500111               65-0248866
-------------------------------      ----------------       --------------------
(State or other jurisdiction of      (Commission File        (I.R.S. Employer
         incorporation)                   Number)           Identification No.)

       3661 West Oakland Park Blvd., Suite 300
                Lauderdale Lakes, FL                                33311
-----------------------------------------------------       --------------------
      (Address of principal executive offices)                    (Zip Code)

       Registrant's telephone number, including area code: (954) 581-9993

                                 NOT APPLICABLE
          -------------------------------------------------------------
          (Former Name or Former Address, if Changed Since Last Report)

Check  the  appropriate  box  below  if the  Form  8-K  filing  is  intended  to
simultaneously  satisfy the filing obligation of the registrant under any of the
following provisions (see General Instruction A.2. below):

|_|   Written  communications  pursuant to Rule 425 under the Securities Act (17
      CFR 230.425)
|_|   Soliciting material pursuant to Rule 14a-12 under the Exchange Act (17 CFR
      240.14a-12)
|_|   Pre-commencement  communications  pursuant  to  Rule  14d-2(b)  under  the
      Exchange Act (17 CFR 240.14d-2(b))
|_|   Pre-commencement  communications  pursuant  to  Rule  13e-4(c)  under  the
      Exchange Act (17 CFR 240.13e-4(c))

<PAGE>

Item 2.02 Results of Operations and Financial Condition.

On March 6, 2006, 21st Century  Holding  Company (the "Company")  issued a press
release to report its results for its fiscal year ended  December  31,  2005.  A
copy of the press  release is  attached  to this  current  report on Form 8-K as
Exhibit 99.1 and incorporated herein by reference.

The  information  in this Current  Report on Form 8-K and Exhibit 99.1  attached
hereto is hereby  intended to be  furnished  pursuant to Item 2.02,  "Results of
Operations and Financial  Condition." As provided in General  Instruction B.6 of
SEC Form 8-K,  such  information  shall not be deemed  "filed"  for  purposes of
Section 18 of the  Securities  Exchange Act of 1934,  as amended (the  "Exchange
Act"), or otherwise subject to the liabilities of that section, and it shall not
be deemed  incorporated  by reference in any filing under the  Securities Act of
1933, as amended,  or under the Exchange  Act,  whether made before or after the
date hereof,  except as expressly set forth by specific reference in such filing
to this Current Report on Form 8-K.

Item 9.01 Financial Statements and Exhibits.

      (c)   Exhibits.
            ---------
      99.1  21st Century Holding Company Press Release, dated March 6, 2006.

<PAGE>

                                   SIGNATURES

Pursuant  to the  requirements  of the  Securities  Exchange  Act of  1934,  the
registrant  has duly  caused  this  report  to be  signed  on its  behalf by the
undersigned hereunto duly authorized.

                                            21ST CENTURY HOLDING COMPANY


Date: March 6, 2006                         By: /s/ James Gordon Jennings, III
                                                --------------------------------
                                            Name:  James Gordon Jennings, III
                                            Title: Chief Financial Officer
                                                   (Principal Accounting and
                                                   Financial Officer)

<PAGE>

                                 EXHIBIT INDEX

Exhibit No.     Exhibit Title
-----------     -------------
   99.1         21st Century Holding Company Press Release, dated March 6, 2006.
{"company-data": {"conformed-name": "21ST CENTURY HOLDING CO", "cik": "0001069996", "assigned-sic": "6331", "irs-number": "650248866", "state-of-incorporation": "FL", "fiscal-year-end": "1231"}, "filing-values": {"form-type": "8-K", "act": "34", "file-number": "000-25001", "film-number": "06667019"}, "business-address": {"street1": "3661 WEST OAKLAND PARK BLVD", "street2": "SUITE 300", "city": "LAUDERDALE LAKES", "state": "FL", "zip": "33311", "phone": "9545819993"}, "mail-address": {"street1": "3661 WEST OAKLAND PARK BLVD", "street2": "SUITE 300", "city": "LAUDERDALE LAKES", "state": "FL", "zip": "33311"}}
UNITED STATES
                       SECURITIES AND EXCHANGE COMMISSION
                             WASHINGTON, D.C. 20549

                                    FORM 8-K

                                 CURRENT REPORT

                     Pursuant to Section 13 or 15(d) of the
                         Securities Exchange Act of 1934

                          Date of Report: March 6, 2006
                        (Date of earliest event reported)

                          21ST CENTURY HOLDING COMPANY
                          ----------------------------
             (Exact name of registrant as specified in its charter)

         Florida                         0-2500111               65-0248866
-------------------------------      ----------------       --------------------
(State or other jurisdiction of      (Commission File        (I.R.S. Employer
         incorporation)                   Number)           Identification No.)

       3661 West Oakland Park Blvd., Suite 300
                Lauderdale Lakes, FL                                33311
-----------------------------------------------------       --------------------
      (Address of principal executive offices)                    (Zip Code)

       Registrant's telephone number, including area code: (954) 581-9993

                                 NOT APPLICABLE
          -------------------------------------------------------------
          (Former Name or Former Address, if Changed Since Last Report)

Check  the  appropriate  box  below  if the  Form  8-K  filing  is  intended  to
simultaneously  satisfy the filing obligation of the registrant under any of the
following provisions (see General Instruction A.2. below):

|_|   Written  communications  pursuant to Rule 425 under the Securities Act (17
      CFR 230.425)
|_|   Soliciting material pursuant to Rule 14a-12 under the Exchange Act (17 CFR
      240.14a-12)
|_|   Pre-commencement  communications  pursuant  to  Rule  14d-2(b)  under  the
      Exchange Act (17 CFR 240.14d-2(b))
|_|   Pre-commencement  communications  pursuant  to  Rule  13e-4(c)  under  the
      Exchange Act (17 CFR 240.13e-4(c))
Item 2.02 Results of Operations and Financial Condition.

On March 6, 2006, 21st Century  Holding  Company (the "Company")  issued a press
release to report its results for its fiscal year ended  December  31,  2005.  A
copy of the press  release is  attached  to this  current  report on Form 8-K as
Exhibit 99.1 and incorporated herein by reference.

The  information  in this Current  Report on Form 8-K and Exhibit 99.1  attached
hereto is hereby  intended to be  furnished  pursuant to Item 2.02,  "Results of
Operations and Financial  Condition." As provided in General  Instruction B.6 of
SEC Form 8-K,  such  information  shall not be deemed  "filed"  for  purposes of
Section 18 of the  Securities  Exchange Act of 1934,  as amended (the  "Exchange
Act"), or otherwise subject to the liabilities of that section, and it shall not
be deemed  incorporated  by reference in any filing under the  Securities Act of
1933, as amended,  or under the Exchange  Act,  whether made before or after the
date hereof,  except as expressly set forth by specific reference in such filing
to this Current Report on Form 8-K.

Item 9.01 Financial Statements and Exhibits.

      (c)   Exhibits.
            ---------
      99.1  21st Century Holding Company Press Release, dated March 6, 2006.
SIGNATURES

Pursuant  to the  requirements  of the  Securities  Exchange  Act of  1934,  the
registrant  has duly  caused  this  report  to be  signed  on its  behalf by the
undersigned hereunto duly authorized.

                                            21ST CENTURY HOLDING COMPANY

Date: March 6, 2006                         By: /s/ James Gordon Jennings, III
                                                --------------------------------
                                            Name:  James Gordon Jennings, III
                                            Title: Chief Financial Officer
                                                   (Principal Accounting and
                                                   Financial Officer)
EXHIBIT INDEX

Exhibit No.     Exhibit Title
-----------     -------------
   99.1         21st Century Holding Company Press Release, dated March 6, 2006.