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        <font style="DISPLAY: inline; FONT-FAMILY: Times New Roman" size="2"><strong>UNITED
        STATES</strong></font></div>
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        <font style="DISPLAY: inline; FONT-FAMILY: Times New Roman" size="2"><strong>SECURITIES
        AND EXCHANGE COMMISSION</strong></font></div>
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        <font style="DISPLAY: inline; FONT-FAMILY: Times New Roman" size="2"><strong>WASHINGTON,
        DC 20549</strong></font></div>
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        <font style="DISPLAY: inline; FONT-FAMILY: Times New Roman" size="2"><strong>FORM
        8-K</strong></font></div>
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        <font style="DISPLAY: inline; FONT-FAMILY: Times New Roman" size="2"><strong>CURRENT
        REPORT PURSUANT</strong></font></div>
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        <font style="DISPLAY: inline; FONT-FAMILY: Times New Roman" size="2"><strong>TO
        SECTION 13 OR 15(D) OF THE</strong></font></div>
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        <font style="DISPLAY: inline; FONT-FAMILY: Times New Roman" size="2"><strong>SECURITIES
        EXCHANGE ACT OF 1934</strong></font></div>
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        <font style="DISPLAY: inline; FONT-FAMILY: Times New Roman" size="2">Date
        of
        report (Date of earliest event reported)<u>
        August 15, 2005</u></font><font id="TAB2" style="COLOR: black; LETTER-SPACING: 441pt" face="Times New Roman" size="2">&#160;</font></div>
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        <font style="DISPLAY: inline; FONT-FAMILY: Times New Roman" size="2"><u>InSite
        Vision Incorporated</u></font></div>
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        <font style="DISPLAY: inline; FONT-FAMILY: Times New Roman" size="2">(Exact
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        <font style="DISPLAY: inline; FONT-FAMILY: Times New Roman" size="2"><u>Delaware</u></font></div>
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        <font style="DISPLAY: inline; FONT-FAMILY: Times New Roman" size="2">(State
        or
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        Incorporation)</font></div>
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                  <font face="Times New Roman" size="2">&#160;<strong><u>0-22332</u></strong><font id="TAB2" style="COLOR: black; LETTER-SPACING: 225pt">&#160;</font></font></div>
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                  <font face="Times New Roman" size="2">&#160;<strong><u>94-3015807</u></strong></font></div>
              </td>
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                  <font face="Times New Roman" size="2">&#160;(Commission
                  File Number)<font id="TAB2" style="COLOR: black; LETTER-SPACING: 225pt">&#160;</font></font></div>
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                  <font style="DISPLAY: inline; FONT-FAMILY: Times New Roman" size="2">(IRS
                  Employer Identification No.)</font></div>
              </td>
            </tr>
            <tr bgcolor="#ffffff">
              <td width="25%"><font face="Times New Roman" size="2">&#160;</font></td>
              <td width="25%"><font face="Times New Roman" size="2">&#160;</font></td>
            </tr>
            <tr bgcolor="#ffffff">
              <td width="25%"><font face="Times New Roman" size="2">&#160;</font></td>
              <td width="25%"><font face="Times New Roman" size="2">&#160;</font></td>
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                <div style="MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt" align="center">
                  <font face="Times New Roman" size="2">&#160;<strong><u>965
                  Atlantic Ave., Alameda,
                  California</u></strong></font></div>
              </td>
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                  <font face="Times New Roman" size="2">&#160;&#160;</font><font style="DISPLAY: inline; FONT-FAMILY: Times New Roman" size="2"><strong><u>94501</u></strong></font></div>
              </td>
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                  <font face="Times New Roman" size="2">&#160;(Address
                  of Principal Executive Offices)</font></div>
              </td>
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                  <font face="Times New Roman" size="2">&#160;&#160;</font><font style="DISPLAY: inline; FONT-FAMILY: Times New Roman" size="2">(Zip
                  Code)</font></div>
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        <font style="DISPLAY: inline; FONT-FAMILY: Times New Roman" size="2"><u>510-865-8800</u></font></div>
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        <font style="DISPLAY: inline; FONT-FAMILY: Times New Roman" size="2">(Registrant&#8217;s
        Telephone Number, Including Area Code)</font></div>
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        <font style="DISPLAY: inline; FONT-FAMILY: Times New Roman" size="2">(Former
        Name or Former Address, if Changed Since Last Report)</font></div>
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        <font face="Times New Roman" size="2"><br></font></div>
      <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 0pt" align="justify">
        <font style="DISPLAY: inline; FONT-FAMILY: Times New Roman" size="2">Check
        the
        appropriate box below if the Form 8-K filing is intended to simultaneously
        satisfy the filing obligation of the registrant under any of the following
        provisions (<em>see
        </em>General
        Instruction A.2. below):</font></div>
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        <font style="DISPLAY: inline; FONT-FAMILY: Times New Roman" size="2">o</font><font id="TAB2" style="COLOR: black; LETTER-SPACING: 9pt" face="Times New Roman" size="2">&#160;</font><font style="DISPLAY: inline; FONT-FAMILY: Times New Roman" size="2">Written
        communications pursuant to Rule 425 under the Securities Act (17 CFR
        230.425)</font></div>
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        <font face="Times New Roman" size="2"><br></font></div>
      <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 0pt" align="justify">
        <font style="DISPLAY: inline; FONT-FAMILY: Times New Roman" size="2">o</font><font id="TAB2" style="COLOR: black; LETTER-SPACING: 9pt" face="Times New Roman" size="2">&#160;</font><font style="DISPLAY: inline; FONT-FAMILY: Times New Roman" size="2">Soliciting
        material pursuant to Rule 14a-12 under the Exchange Act (17 CFR
        240.14a-12)</font></div>
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      <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 0pt" align="justify">
        <font style="DISPLAY: inline; FONT-FAMILY: Times New Roman" size="2">o</font><font id="TAB2" style="COLOR: black; LETTER-SPACING: 9pt" face="Times New Roman" size="2">&#160;</font><font style="DISPLAY: inline; FONT-FAMILY: Times New Roman" size="2">Pre-commencement
        communications pursuant to Rule 14d-2(b) under the Exchange Act (17 CFR
        240.14d-2(b))</font></div>
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      <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 0pt" align="justify">
        <font style="DISPLAY: inline; FONT-FAMILY: Times New Roman" size="2">o</font><font id="TAB2" style="COLOR: black; LETTER-SPACING: 9pt" face="Times New Roman" size="2">&#160;</font><font style="DISPLAY: inline; FONT-FAMILY: Times New Roman" size="2">Pre-commencement
        communications pursuant to Rule 13e-4(c) under the Exchange Act (17 CFR
        240.13e-4(c))</font></div>
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        <font face="Times New Roman" size="2">&#160;</font></div>
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        <div id="FTR">
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            <font face="Times New Roman" size="2">&#160;</font></div>
          <div style="WIDTH: 100%; TEXT-ALIGN: center">
            <hr style="COLOR: black" noshade size="2">
          </div>
        </div>
        <div id="HDR">
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            <font face="Times New Roman" size="2">&#160;</font></div>
        </div>
      </div>
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        <font face="Times New Roman" size="2"><br></font></div>
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        <font style="DISPLAY: inline; FONT-FAMILY: Times New Roman" size="2">TABLE
        OF
        CONTENTS</font></div>
      <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 0pt" align="center">
        <font face="Times New Roman" size="2"><br></font></div>
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              <td width="12%"><font face="Times New Roman" size="2">ITEM 2.02.</font></td>
              <td width="2%"><font face="Times New Roman" size="2">&#160;</font></td>
              <td width="80%"><font face="Times New Roman" size="2">RESULTS OF OPERATIONS AND FINANCIAL CONDITION</font></td>
              <td width="2%"><font face="Times New Roman" size="2">&#160;</font></td>
              <td width="4%">
              <font style="DISPLAY: inline; FONT-FAMILY: Times New Roman" size="2">3</font></td>
            </tr>
            <tr bgcolor="#ffffff">
              <td width="12%"><font face="Times New Roman" size="2">ITEM 9.</font></td>
              <td width="2%"><font face="Times New Roman" size="2">&#160;</font></td>
              <td width="80%"><font face="Times New Roman" size="2">FINANCIAL STATEMENTS AND EXHIBITS</font></td>
              <td width="2%"><font face="Times New Roman" size="2">&#160;</font></td>
              <td width="4%">
              <font style="DISPLAY: inline; FONT-FAMILY: Times New Roman" size="2">3</font></td>
            </tr>
            <tr bgcolor="#ccffcc">
              <td width="12%"><font face="Times New Roman" size="2">&#160;</font></td>
              <td width="2%"><font face="Times New Roman" size="2">&#160;</font></td>
              <td width="80%"><font face="Times New Roman" size="2">SIGNATURES</font></td>
              <td width="2%"><font face="Times New Roman" size="2">&#160;</font></td>
              <td width="4%">
                <div style="MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt" align="left">
                  <font face="Times New Roman" size="2">4</font></div>
              </td>
            </tr>
            <tr bgcolor="#ffffff">
              <td width="12%"><font face="Times New Roman" size="2">&#160;</font></td>
              <td width="2%"><font face="Times New Roman" size="2">&#160;</font></td>
              <td width="80%"><font face="Times New Roman" size="2">EXHIBIT INDEX</font></td>
              <td width="2%"><font face="Times New Roman" size="2">&#160;</font></td>
              <td width="4%"><font face="Times New Roman" size="2">5</font></td>
            </tr>
            <tr bgcolor="#ccffcc">
              <td width="12%"><font face="Times New Roman" size="2">&#160;</font></td>
              <td width="2%"><font face="Times New Roman" size="2">&#160;</font></td>
              <td width="80%"><font face="Times New Roman" size="2">Exhibit 99.1</font></td>
              <td width="2%"><font face="Times New Roman" size="2">&#160;</font></td>
              <td width="4%"><font face="Times New Roman" size="2">&#160;</font></td>
            </tr>

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      </div>
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        <font face="Times New Roman">
        <font id="TAB2" style="COLOR: black; LETTER-SPACING: 27pt" size="2">&#160;&#160;</font></font></div>
      <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 0pt" align="left">
        <font face="Times New Roman">
        <font id="TAB2" style="COLOR: black; LETTER-SPACING: 27pt" size="2">&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;</font></font></div>
      <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 0pt" align="left">
        <font face="Times New Roman">
        <font id="TAB2" style="COLOR: black; LETTER-SPACING: 27pt" size="2">&#160;&#160;&#160;&#160;&#160;&#160;&#160;</font></font></div>
      <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 0pt" align="left">
        <font face="Times New Roman" size="2">&#160;</font></div>
      <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 0pt" align="left">
        <font face="Times New Roman" size="2"><br></font></div>
      <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 0pt" align="justify">
        <font face="Times New Roman" size="2"><br></font></div>
      <div id="PGBRK" style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 0pt" align="justify">
        <div id="FTR">
          <div id="GLFTR" style="WIDTH: 100%" align="left">
            <font face="Times New Roman" size="2">&#160;</font></div>
        </div>
        <div id="PN" style="PAGE-BREAK-AFTER: always">
          <div style="WIDTH: 100%; TEXT-ALIGN: center">
            <font face="Times New Roman" size="2">&#160;</font></div>
          <div style="WIDTH: 100%; TEXT-ALIGN: center">
            <hr style="COLOR: black" noshade size="2">
          </div>
        </div>
        <div id="HDR">
          <div id="GLHDR" style="WIDTH: 100%" align="right">
            <font face="Times New Roman" size="2">&#160;</font></div>
        </div>
      </div>
      <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 0pt" align="justify">
        <font face="Times New Roman" size="2"><br></font></div>
      <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 0pt" align="left">
        <font style="DISPLAY: inline; FONT-FAMILY: Times New Roman" size="2"><strong><u>ITEM
        2.02</u></strong></font><font id="TAB2" style="COLOR: black; LETTER-SPACING: 27pt" face="Times New Roman" size="2">&#160;</font><font style="DISPLAY: inline; FONT-FAMILY: Times New Roman" size="2"><strong><u>RESULTS
        OF OPERATIONS AND FINANCIAL CONDITION</u></strong></font><font id="TAB2" style="COLOR: black; LETTER-SPACING: 27pt" face="Times New Roman" size="2">&#160;</font></div>
      <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 0pt" align="left">
        <font face="Times New Roman" size="2"><br></font></div>
      <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 0pt" align="left">
        <font style="DISPLAY: inline; FONT-FAMILY: Times New Roman" size="2">On
        August
        15, 2005, we issued a press release, which, among other things, sets forth
        our
        results of operations for the six months and quarter ended June 30, 2005.
        A copy
        of the press release is attached hereto as Exhibit 99.1 and is incorporated
        herein by this reference. The information in this Item 2.02, including Exhibit
        99.1, is being furnished and shall not be deemed to be "filed" for purposes
        of
        Section 18 of the Securities Exchange Act of 1934 (the "Exchange Act") or
        otherwise subject to the liability of that Section, nor shall such information
        be deemed to be incorporated by reference in any registration statement or
        other
        document filed under the Securities Act of 1933 or the Exchange Act, except
        as
        otherwise stated in such filing.</font></div>
      <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 0pt" align="left">
        <font face="Times New Roman" size="2"><br></font></div>
      <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 0pt" align="left">
        <font face="Times New Roman" size="2"><br></font></div>
      <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 0pt" align="left">
        <font style="DISPLAY: inline; FONT-FAMILY: Times New Roman" size="2"><strong><u>ITEM
        9.01</u></strong></font><font id="TAB2" style="COLOR: black; LETTER-SPACING: 27pt" face="Times New Roman" size="2">&#160;</font><font style="DISPLAY: inline; FONT-FAMILY: Times New Roman" size="2"><strong><u>FINANCIAL
        STATEMENTS AND EXHIBITS</u></strong></font></div>
      <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 0pt" align="left">
        <font face="Times New Roman" size="2"><br></font></div>
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{"company-data": {"conformed-name": "INSITE VISION INC", "cik": "0000802724", "assigned-sic": "2834", "irs-number": "943015807", "state-of-incorporation": "DE", "fiscal-year-end": "1231"}, "filing-values": {"form-type": "8-K", "act": "34", "file-number": "001-14207", "film-number": "051023587"}, "business-address": {"street1": "965 ATLANTIC AVE", "street2": "--", "city": "ALAMEDA", "state": "CA", "zip": "94501", "phone": "5108658800"}, "mail-address": {"street1": "965 ATLANTIC AVE", "street2": "---", "city": "ALAMEDA", "state": "CA", "zip": "94501"}}
UNITED
        STATES
SECURITIES
        AND EXCHANGE COMMISSION
WASHINGTON,
        DC 20549
FORM
        8-K
CURRENT
        REPORT PURSUANT
TO
        SECTION 13 OR 15(D) OF THE
SECURITIES
        EXCHANGE ACT OF 1934
Date
        of
        report (Date of earliest event reported)
August 15, 2005
InSite
        Vision Incorporated
(Exact
        Name of Registrant as Specified in Its Charter)
Delaware
(State
        or
        Other Jurisdiction of
        Incorporation)
0-22332
94-3015807
(Commission
                  File Number)
(IRS
                  Employer Identification No.)
965
                  Atlantic Ave., Alameda,
                  California
94501
(Address
                  of Principal Executive Offices)
(Zip
                  Code)
510-865-8800
(Registrant's
        Telephone Number, Including Area Code)
(Former
        Name or Former Address, if Changed Since Last Report)
Check
        the
        appropriate box below if the Form 8-K filing is intended to simultaneously
        satisfy the filing obligation of the registrant under any of the following
        provisions (
see
General
        Instruction A.2. below):
o
Written
        communications pursuant to Rule 425 under the Securities Act (17 CFR
        230.425)
o
Soliciting
        material pursuant to Rule 14a-12 under the Exchange Act (17 CFR
        240.14a-12)
o
Pre-commencement
        communications pursuant to Rule 14d-2(b) under the Exchange Act (17 CFR
        240.14d-2(b))
o
Pre-commencement
        communications pursuant to Rule 13e-4(c) under the Exchange Act (17 CFR
        240.13e-4(c))
TABLE
        OF
        CONTENTS
ITEM 2.02.
RESULTS OF OPERATIONS AND FINANCIAL CONDITION
3
ITEM 9.
FINANCIAL STATEMENTS AND EXHIBITS
3
SIGNATURES
4
EXHIBIT INDEX
5
Exhibit 99.1
ITEM
        2.02
RESULTS
        OF OPERATIONS AND FINANCIAL CONDITION
On
        August
        15, 2005, we issued a press release, which, among other things, sets forth
        our
        results of operations for the six months and quarter ended June 30, 2005.
        A copy
        of the press release is attached hereto as Exhibit 99.1 and is incorporated
        herein by this reference. The information in this Item 2.02, including Exhibit
        99.1, is being furnished and shall not be deemed to be "filed" for purposes
        of
        Section 18 of the Securities Exchange Act of 1934 (the "Exchange Act") or
        otherwise subject to the liability of that Section, nor shall such information
        be deemed to be incorporated by reference in any registration statement or
        other
        document filed under the Securities Act of 1933 or the Exchange Act, except
        as
        otherwise stated in such filing.
ITEM
        9.01
FINANCIAL
        STATEMENTS AND EXHIBITS
(c)
EXHIBITS
Exhibit
        No.
Description
99.1
InSite
        Vision Incorporated Press Release dated August 15, 2005.
SIGNATURES
Pursuant
        to the requirements of the Securities Exchange Act of 1934, as amended, the
        registrant has duly caused this report to be signed on its behalf by the
        undersigned thereunto duly authorized.
INSITE
                VISION INCORPORATED
Date:
August
                15, 2005
By:
/s/
                S. Kumar Chandrasekaran, Ph.D.
S. Kumar Chandrasekaran, Ph.D.
Chairman
                of the Board,
Chief Executive Officer,
                President
and Chief Financial Officer
(on behalf of the registrant and as principal
financial and accounting officer)
EXHIBIT
        INDEX
Exhibit
          No.
Description
99.1
InSite
          Vision Incorporated Press Release dated August 15, 2005.