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      <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 0pt" align="center">&#160;</div>
      <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 0pt" align="center"><font style="DISPLAY: inline; FONT-SIZE: 12pt; FONT-FAMILY: Times New Roman"><strong>SECURITIES
        AND EXCHANGE COMMISSION</strong></font></div>
      <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 0pt" align="center"><font style="DISPLAY: inline; FONT-SIZE: 12pt; FONT-FAMILY: Times New Roman"><strong>WASHINGTON,
        D.C.&#160;&#160;20549</strong></font></div>
      <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 0pt" align="justify">&#160;</div>
      <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 0pt" align="center"><font style="DISPLAY: inline; FONT-SIZE: 12pt; FONT-FAMILY: Times New Roman"><strong>FORM
        8-K</strong></font></div>
      <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 0pt" align="justify">&#160;</div>
      <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 0pt" align="center"><font style="DISPLAY: inline; FONT-SIZE: 12pt; FONT-FAMILY: Times New Roman"><strong>CURRENT
        REPORT</strong></font></div>
      <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 0pt" align="center"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman"><strong>Pursuant
        to Section 13 OR 15(d) of the Securities Exchange Act of
        1934</strong></font></div>
      <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 0pt" align="justify"><br>&#160;</div>
      <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 0pt" align="center"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman">DATE
        OF
        REPORT - NOVEMBER 15, 2005</font></div>
      <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 0pt" align="justify">&#160;</div>
      <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 0pt" align="center"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman">(Date
        of
        Earliest Event Reported)</font></div>
      <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 0pt" align="justify">&#160;</div>
      <div style="DISPLAY: block; MARGIN-LEFT: 90pt; TEXT-INDENT: 0pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 86.4pt" align="center"><font style="DISPLAY: inline; FONT-SIZE: 12pt; FONT-FAMILY: Times New Roman"><strong><u>COLUMBIA
        LABORATORIES, INC.</u></strong></font></div>
      <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 0pt" align="center"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman">(Exact
        name of registrant as specified in its charter)</font></div>
      <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 0pt" align="justify">&#160;</div>
      <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 0pt" align="center"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman">Commission
        File No. 1-10352</font></div>
      <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 0pt" align="center">&#160;</div>
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                <div style="DISPLAY: block; MARGIN-LEFT: 27pt; TEXT-INDENT: 0pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 21.6pt" align="center"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman">Delaware</font></div>
              </td>
              <td align="left" valign="top" width="10%">&#160;</td>
              <td valign="top" width="45%" style="BORDER-BOTTOM: black thin solid">
                <div style="DISPLAY: block; MARGIN-LEFT: 27pt; TEXT-INDENT: 0pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 21.6pt" align="center"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman">59-2758596</font></div>
              </td>
            </tr>
            <tr>
              <td valign="top" width="45%">
                <div style="DISPLAY: block; MARGIN-LEFT: 27pt; TEXT-INDENT: 0pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 21.6pt" align="center"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman">(State
                  of Incorporation)</font></div>
              </td>
              <td align="left" valign="top" width="10%">&#160;</td>
              <td valign="top" width="45%">
                <div style="DISPLAY: block; MARGIN-LEFT: 27pt; TEXT-INDENT: 0pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 21.6pt" align="center"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman">(I.R.S.
                  Employer</font></div>
                <div style="DISPLAY: block; MARGIN-LEFT: 27pt; TEXT-INDENT: 0pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 21.6pt" align="center"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman">Identification
                  No.)</font></div>
              </td>
            </tr>
            <tr>
              <td valign="top" width="45%">&#160;</td>
              <td align="left" valign="top" width="10%">&#160;</td>
              <td valign="top" width="45%">&#160;</td>
            </tr>
            <tr>
              <td valign="top" width="45%" style="BORDER-BOTTOM: black thin solid">
                <div style="DISPLAY: block; MARGIN-LEFT: 27pt; TEXT-INDENT: 0pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 21.6pt" align="center"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman">354
                  Eisenhower Parkway</font></div>
                <div style="DISPLAY: block; MARGIN-LEFT: 27pt; TEXT-INDENT: 0pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 21.6pt" align="center"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman">Livingston,
                  New Jersey</font></div>
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              <td align="left" valign="top" width="10%">&#160;</td>
              <td valign="top" width="45%" style="BORDER-BOTTOM: black thin solid">
                <div style="DISPLAY: block; MARGIN-LEFT: 27pt; TEXT-INDENT: 0pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 21.6pt" align="center">&#160;</div>
                <div style="DISPLAY: block; MARGIN-LEFT: 27pt; TEXT-INDENT: 0pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 21.6pt" align="center"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman">07039</font></div>
              </td>
            </tr>
            <tr>
              <td valign="top" width="45%">
                <div style="DISPLAY: block; MARGIN-LEFT: 27pt; TEXT-INDENT: 0pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 21.6pt" align="center"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman">(Address
                  of principal</font></div>
                <div style="DISPLAY: block; MARGIN-LEFT: 27pt; TEXT-INDENT: 0pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 21.6pt" align="center"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman">executive
                  offices)</font></div>
              </td>
              <td align="left" valign="top" width="10%">&#160;</td>
              <td valign="top" width="45%">
                <div style="DISPLAY: block; MARGIN-LEFT: 27pt; TEXT-INDENT: 0pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 21.6pt" align="center"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman">Zip
                  Code</font></div>
              </td>
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      <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 0pt" align="justify">&#160;</div>
      <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 0pt" align="center"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman">Registrant&#8217;s
        telephone number, including area code: (973) 994-3999</font></div>
      <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 0pt" align="justify">&#160;</div>
      <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 0pt" align="left"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman">Check
        the
        appropriate box below if the Form 8-K filing is intended to simultaneously
        satisfy the filing obligation of the registrant under any of the following
        provisions (see General Instruction A.2. below):</font></div>
      <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 0pt" align="left"><br></div>
      <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 0pt" align="left">
        <div>
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        </div><br>
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                <td align="left" valign="top" width="5%" style="BORDER-BOTTOM: medium none">
                  <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 0pt" align="left"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman"><font style="DISPLAY: inline; FONT-FAMILY: Wingdings">o</font></font></div>
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                    communications pursuant to Rule 425 under the Securities Act
                    (17 CFR
                    230.425)</font></div>
                </td>
              </tr>
              <tr>
                <td align="left" valign="top" width="5%" style="BORDER-BOTTOM: medium none">
                  <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 0pt" align="left">
                    <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 0pt" align="left">
                      <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 0pt" align="left"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman"><font style="DISPLAY: inline; FONT-FAMILY: Wingdings">o</font></font></div>
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                <td align="left" valign="top" width="95%" style="BORDER-BOTTOM: medium none">
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                    material pursuant to Rule 14a-12 under the Exchange Act (17 CFR
                    240.14a-12)</font></div>
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              <tr>
                <td align="left" valign="top" width="5%" style="BORDER-BOTTOM: medium none">
                  <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 0pt" align="left">
                    <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 0pt" align="left"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman"><font style="DISPLAY: inline; FONT-FAMILY: Wingdings">o</font></font></div>
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                    communications pursuant to Rule 14d-2(b) under the Exchange Act
                    (17 CFR
                    240.14d-2(b))</font></div>
                </td>
              </tr>
              <tr>
                <td align="left" valign="top" width="5%" style="BORDER-BOTTOM: medium none">
                  <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 0pt" align="left">
                    <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 0pt" align="left"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman"><font style="DISPLAY: inline; FONT-FAMILY: Wingdings">o</font></font></div>
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                <td align="left" valign="top" width="95%" style="BORDER-BOTTOM: medium none">
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                    (17 CFR
                    240.13e-4(c))</font></div>
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      <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 0pt" align="justify">&#160;</div>
      <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 0pt" align="justify">
        <hr style="COLOR: #000000" align="left" noshade size="1" width="100%">
        &#160;</div>
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                  <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 0pt" align="left"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman"><strong>Item
                    1.01.</strong></font></div>
                </td>
                <td align="left" valign="top" width="92%" style="BORDER-BOTTOM: medium none">
                  <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 0pt" align="left"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman"><strong>Entry
                    into a Material Definitive
                    Agreement.</strong></font></div>
                </td>
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      </div>
      <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 0pt" align="left"><br></div>
      <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 36pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 0pt" align="left"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman">On
        November 16, 2005, Columbia Laboratories, Inc. (the "Company") entered into
        Indemnification Agreements in substantially the form filed and incorporated
        by
        reference to the Company&#8217;s 2003 Form 10-K as Exhibit 10.46, with </font><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman">Valerie
        L. Andrews and James S. Crofton</font><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman">,
        each of
        whom is a Director of the Company. </font></div>
      <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 36pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 0pt" align="left"><br></div>
      <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 36pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 0pt" align="left"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman">Pursuant
        to each Indemnification Agreement (the &#8220;Agreement&#8221;), the Company agrees to
        indemnify, and advance Expenses (as defined in the Agreement) to, each Director
        (an &#8220;Indemnitee&#8221;) to the fullest extent permitted by applicable law. The
        Agreement is a supplement to, and in furtherance of, the amended and restated
        by-laws and the Certification of Incorporation of the Company. </font></div>
      <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 0pt" align="left"><br></div>
      <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 0pt" align="left"><font id="TAB1" style="MARGIN-LEFT: 36pt"></font><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman">An
        Indemnitee is entitled to indemnification in any threatened, pending or
        completed Proceeding (as defined in the Agreement), including a Proceeding
        brought by the Company, against Expenses if Indemnitee acted in good faith
        and
        in a manner Indemnitee reasonably believed to be in, or not opposed to, the
        best
        interests of the Company, and, with respect to any criminal Proceeding, had
        no
        reasonable cause to believe Indemnitee&#8217;s conduct was unlawful. In a Proceeding
        brought by the Company, however, no indemnification applies against Expenses
        for
        any claim, issue or matter in any Proceeding as to which Indemnitee is
        determined to be liable to the Company if indemnification is prohibited by
        law,
        unless the Court of Chancery of the State of Delaware, or the court in
        which&#160;a Proceeding is brought or pending, determines that indemnification
        may nevertheless be made by the Company. Indemnitee is also indemnified against
        all Expenses incurred as a witness in any Proceeding.</font></div>
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      <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 36pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 0pt" align="left"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman">If
        Indemnitee is successful, on the merits or otherwise, in any Proceeding,
        Indemnitee is indemnified against all Indemnitee&#8217;s Expenses. If Indemnitee is
        only successful as to one or more, but less than all claims, issues or matters,
        indemnification applies to Expenses for each successfully resolved claim,
        issue
        or matter. The termination of any claim, issue or matter by dismissal, with
        or
        without prejudice, is a successful result.</font></div>
      <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 36pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 0pt" align="left">&#160;</div>
      <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 0pt" align="left"><font id="TAB1" style="MARGIN-LEFT: 36pt"></font><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman">Indemnitee
        is not entitled to indemnification or advancement of Expenses with respect
        to
        any Proceeding brought by Indemnitee against the Company, except if Indemnitee
        prevails in a judicial adjudication of Indemnitee&#8217;s rights under, or to recover
        damages for breach of, the Agreement.</font></div>
      <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 0pt" align="left">&#160;</div>
      <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 0pt" align="left"><font id="TAB1" style="MARGIN-LEFT: 36pt"></font><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman">The
        Company will advance all Expenses of Indemnitee in connection with any
        Proceeding within thirty days after the receipt by the Company of a statement
        from Indemnitee requesting such advance, whether prior to or after final
        disposition, provided Indemnitee agrees to repay any Expenses advanced if
        it is
        ultimately determined that Indemnitee is not entitled to be indemnified against
        such Expenses.</font></div>
      <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 0pt" align="right"><br></div>
      <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 36pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 0pt" align="left"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman">The
        Indemnitee is required to make a written request to the Company with reasonable
        documentation and information to obtain indemnification. Depending on the
        circumstances (as described in the Agreement) the Indemnitee&#8217;s entitlement to
        indemnification may be determined by either an Independent Counsel (as defined
        in the Agreement), by Disinterested Directors (as defined in the Agreement),
        or
        the stockholders of the Company. If a Change in Control (as defined in the
        Agreement) has occurred, the person making the determination is required
        to
        presume that the Indemnitee is entitled to indemnification. Any costs or
        expenses incurred by Indemnitee in making the determination will be borne
        by the
        Company (irrespective of the determination as to Indemnitee&#8217;s entitlement to
        indemnification).</font></div>
      <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 0pt" align="left"><br></div>
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      <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 0pt" align="left"><font id="TAB1" style="MARGIN-LEFT: 36pt"></font><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman">The
        termination of any Proceeding (or any claim, issue or matter in a Proceeding)
        by
        judgment, order, settlement or conviction, or upon a plea of </font><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman"><em>nolo
        contendere</em></font><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman">
        or its
        equivalent, will not (except as otherwise expressly provided in the Agreement)
        of itself adversely affect the right of Indemnitee to indemnification or
        create
        a presumption that Indemnitee did not act in good faith and in a manner that
        Indemnitee reasonably believed to be in or not opposed to the best interests
        of
        the Company or, with respect to any criminal Proceeding, that Indemnitee
        had
        reasonable cause to believe that Indemnitee&#8217;s conduct was unlawful.
</font></div>
      <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 0pt" align="left"><br></div>
      <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 36pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 0pt" align="left"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman">In
        the
        event that (i)&#160;a determination is made that Indemnitee is not entitled
        to
        indemnification, (ii)&#160;advancement of Expenses is not timely made,
        (iii)&#160;the determination of entitlement to indemnification is not timely
        made, or (iv)&#160;payment of indemnification is not timely made, Indemnitee
        may
        seek an adjudication in an appropriate court of the State of Delaware or
        New
        Jersey of Indemnitee&#8217;s entitlement to indemnification or advancement of
        Expenses. The Company is precluded from asserting in any judicial proceeding
        that the procedures and presumptions of the Agreement are not valid, binding
        and
        enforceable and the Company must stipulate that the Company is bound by all
        the
        provisions of the Agreement. If the Indemnitee seeks a judicial adjudication
        of
        Indemnitee&#8217;s rights under, or to recover damages for breach of, the Agreement,
        Indemnitee will be entitled to recover all Expenses, but only for the issues
        on
        which Indemnitee prevails. </font></div>
      <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 0pt" align="left"><br></div>
      <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 36pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 0pt" align="left"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman">To
        the
        extent that the Company maintains an insurance policy providing liability
        insurance for directors, officers, employees, agents or fiduciaries of the
        Company, Indemnitee will be covered by such policy in accordance with its
        terms
        to the maximum extent of the coverage available for any director, officer,
        employee, agent or fiduciary. The Company is not liable to make any payment
        otherwise indemnifiable under the Agreement if and to the extent that Indemnitee
        has received payment under any insurance policy, contract, agreement or
        otherwise.</font></div>
      <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 0pt" align="left"><br></div>
      <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 0pt" align="left"><font id="TAB1" style="MARGIN-LEFT: 36pt"></font><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman">The
        Agreement terminates upon the later of: (a)&#160;ten years after the date
        that
        Indemnitee ceases to serve as a director, officer, employee, agent or fiduciary
        of the Company; or (b)&#160;the final termination of all pending Proceedings
        and
        of any proceeding commenced by Indemnitee.</font></div>
      <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 0pt" align="left">&#160;</div>
      <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 0pt" align="left">
        <div align="left">
          <div align="left">
            <table border="0" cellpadding="0" cellspacing="0" width="100%">

                <tr>
                  <td align="left" valign="top" width="8%" style="BORDER-BOTTOM: medium none">
                    <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 0pt" align="left"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman"><strong>Item
                      5.02.</strong></font></div>
                  </td>
                  <td align="left" valign="top" width="92%" style="BORDER-BOTTOM: medium none">
                    <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 0pt" align="left"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman"><strong>Departure
                      of Directors or Principal Officers; Election of Directors;
                      Appointment of
                      Principal Officers.
</strong></font></div>
                  </td>
                </tr>

            </table>
          </div>
        </div>
      </div>
      <div style="DISPLAY: block; MARGIN-LEFT: 72pt; TEXT-INDENT: 0pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 0pt" align="left">&#160;</div>
      <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 36pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 0pt" align="left"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman">On
        November 15, 2005, the Chairman of the Board of Directors of Columbia
        Laboratories, Inc., (the &#8220;Company&#8221;) received a letter from Robert C. Strauss, a
        Director of the Company, notifying him that Mr. Strauss will retire from
        the
        Company&#8217;s Board of Directors effective December 31, 2005. Mr. Strauss will
        continue as a member of the Board of Directors, and will continue as chair
        of
        the Company&#8217;s Audit Committee and as a member of the Compensation Committee
        until December 31, 2005.</font></div>
      <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 36pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 0pt" align="left">&#160;</div>
      <div id="PGBRK" style="MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt">
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      <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 0pt" align="justify">&#160;</div>
      <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 50.4pt" align="left"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman">Pursuant
        to the requirements of the Securities Exchange Act of 1934, the registrant
        has
        duly caused this report to be signed on its behalf by the undersigned hereunto
        duly authorized.</font></div>
      <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 0pt" align="justify">&#160;</div>
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        <table align="center" bgcolor="#ffffff" border="0" cellpadding="0" cellspacing="0" width="100%">

            <tr valign="top" bgcolor="#ffffff">
              <td width="50%"><font size="2">Date: November 16, 2005</font></td>
              <td width="1%">&#160;</td>
              <td width="49%">&#160;</td>
            </tr>
            <tr valign="top" bgcolor="#ffffff">
              <td width="50%">&#160;</td>
              <td width="1%">&#160;</td>
              <td width="49%">&#160;</td>
            </tr>
            <tr valign="top" bgcolor="#ffffff">
              <td width="50%"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman">&#160;</font></td>
              <td width="1%"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman">&#160;</font></td>
              <td width="49%"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman">&#160;</font></td>
            </tr>
            <tr valign="top" bgcolor="#ffffff">
              <td><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman">&#160;</font></td>
              <td colspan="2"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman"><strong>COLUMBIA
                LABORATORIES, INC.</strong></font></td>
            </tr>
            <tr valign="top" bgcolor="#ffffff">
              <td><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman">&#160;<br>&#160;</font></td>
              <td><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman">&#160;<br>&#160;</font></td>
              <td><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman">&#160;<br>&#160;</font></td>
            </tr>
            <tr valign="top" bgcolor="#ffffff">
              <td>&#160;</td>
              <td><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman">By:&#160;&#160;</font></td>
              <td><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman">/s/&#160;David
                L. Weinberg</font></td>
            </tr>
            <tr valign="top" bgcolor="#ffffff">
              <td colspan="2"><font style="FONT-FAMILY: Times New Roman" size="1">&#160;</font></td>
              <td align="left">
                <div>
                  <hr style="COLOR: #000000" align="left" noshade size="2" width="80%">
                </div>
                <div><font size="2">David L. Weinberg</font></div>
                <div><font size="2">Vice President and Chief Financial Officer
                  </font></div>
              </td>
            </tr>

        </table>
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{"company-data": {"conformed-name": "COLUMBIA LABORATORIES INC", "cik": "0000821995", "assigned-sic": "2834", "irs-number": "592758596", "state-of-incorporation": "DE", "fiscal-year-end": "1231"}, "filing-values": {"form-type": "8-K", "act": "34", "file-number": "001-10352", "film-number": "051210754"}, "business-address": {"street1": "354 EISENHOWER PARKWAY", "city": "LIVINGSTON", "state": "NJ", "zip": "07039", "phone": "9739943999"}, "mail-address": {"street1": "354 EISENHOWER PARKWAY", "city": "LIVINGSTON", "state": "NJ", "zip": "07039"}}
SECURITIES
        AND EXCHANGE COMMISSION
WASHINGTON,
        D.C.  20549
FORM
        8-K
CURRENT
        REPORT
Pursuant
        to Section 13 OR 15(d) of the Securities Exchange Act of
        1934
DATE
        OF
        REPORT - NOVEMBER 15, 2005
(Date
        of
        Earliest Event Reported)
COLUMBIA
        LABORATORIES, INC.
(Exact
        name of registrant as specified in its charter)
Commission
        File No. 1-10352
Delaware
59-2758596
(State
                  of Incorporation)
(I.R.S.
                  Employer
Identification
                  No.)
354
                  Eisenhower Parkway
Livingston,
                  New Jersey
07039
(Address
                  of principal
executive
                  offices)
Zip
                  Code
Registrant's
        telephone number, including area code: (973) 994-3999
Check
        the
        appropriate box below if the Form 8-K filing is intended to simultaneously
        satisfy the filing obligation of the registrant under any of the following
        provisions (see General Instruction A.2. below):
o
Written
                    communications pursuant to Rule 425 under the Securities Act
                    (17 CFR
                    230.425)
o
Soliciting
                    material pursuant to Rule 14a-12 under the Exchange Act (17 CFR
                    240.14a-12)
o
Pre-commencement
                    communications pursuant to Rule 14d-2(b) under the Exchange Act
                    (17 CFR
                    240.14d-2(b))
o
Pre-commencement
                    communications pursuant to Rule 13e-4(c) under the Exchange Act
                    (17 CFR
                    240.13e-4(c))
Item
                    1.01.
Entry
                    into a Material Definitive
                    Agreement.
On
        November 16, 2005, Columbia Laboratories, Inc. (the "Company") entered into
        Indemnification Agreements in substantially the form filed and incorporated
        by
        reference to the Company's 2003 Form 10-K as Exhibit 10.46, with
Valerie
        L. Andrews and James S. Crofton
,
        each of
        whom is a Director of the Company.
Pursuant
        to each Indemnification Agreement (the "Agreement"), the Company agrees to
        indemnify, and advance Expenses (as defined in the Agreement) to, each Director
        (an "Indemnitee") to the fullest extent permitted by applicable law. The
        Agreement is a supplement to, and in furtherance of, the amended and restated
        by-laws and the Certification of Incorporation of the Company.
An
        Indemnitee is entitled to indemnification in any threatened, pending or
        completed Proceeding (as defined in the Agreement), including a Proceeding
        brought by the Company, against Expenses if Indemnitee acted in good faith
        and
        in a manner Indemnitee reasonably believed to be in, or not opposed to, the
        best
        interests of the Company, and, with respect to any criminal Proceeding, had
        no
        reasonable cause to believe Indemnitee's conduct was unlawful. In a Proceeding
        brought by the Company, however, no indemnification applies against Expenses
        for
        any claim, issue or matter in any Proceeding as to which Indemnitee is
        determined to be liable to the Company if indemnification is prohibited by
        law,
        unless the Court of Chancery of the State of Delaware, or the court in
        which a Proceeding is brought or pending, determines that indemnification
        may nevertheless be made by the Company. Indemnitee is also indemnified against
        all Expenses incurred as a witness in any Proceeding.
If
        Indemnitee is successful, on the merits or otherwise, in any Proceeding,
        Indemnitee is indemnified against all Indemnitee's Expenses. If Indemnitee is
        only successful as to one or more, but less than all claims, issues or matters,
        indemnification applies to Expenses for each successfully resolved claim,
        issue
        or matter. The termination of any claim, issue or matter by dismissal, with
        or
        without prejudice, is a successful result.
Indemnitee
        is not entitled to indemnification or advancement of Expenses with respect
        to
        any Proceeding brought by Indemnitee against the Company, except if Indemnitee
        prevails in a judicial adjudication of Indemnitee's rights under, or to recover
        damages for breach of, the Agreement.
The
        Company will advance all Expenses of Indemnitee in connection with any
        Proceeding within thirty days after the receipt by the Company of a statement
        from Indemnitee requesting such advance, whether prior to or after final
        disposition, provided Indemnitee agrees to repay any Expenses advanced if
        it is
        ultimately determined that Indemnitee is not entitled to be indemnified against
        such Expenses.
The
        Indemnitee is required to make a written request to the Company with reasonable
        documentation and information to obtain indemnification. Depending on the
        circumstances (as described in the Agreement) the Indemnitee's entitlement to
        indemnification may be determined by either an Independent Counsel (as defined
        in the Agreement), by Disinterested Directors (as defined in the Agreement),
        or
        the stockholders of the Company. If a Change in Control (as defined in the
        Agreement) has occurred, the person making the determination is required
        to
        presume that the Indemnitee is entitled to indemnification. Any costs or
        expenses incurred by Indemnitee in making the determination will be borne
        by the
        Company (irrespective of the determination as to Indemnitee's entitlement to
        indemnification).
The
        termination of any Proceeding (or any claim, issue or matter in a Proceeding)
        by
        judgment, order, settlement or conviction, or upon a plea of
nolo
        contendere
or its
        equivalent, will not (except as otherwise expressly provided in the Agreement)
        of itself adversely affect the right of Indemnitee to indemnification or
        create
        a presumption that Indemnitee did not act in good faith and in a manner that
        Indemnitee reasonably believed to be in or not opposed to the best interests
        of
        the Company or, with respect to any criminal Proceeding, that Indemnitee
        had
        reasonable cause to believe that Indemnitee's conduct was unlawful.
In
        the
        event that (i) a determination is made that Indemnitee is not entitled
        to
        indemnification, (ii) advancement of Expenses is not timely made,
        (iii) the determination of entitlement to indemnification is not timely
        made, or (iv) payment of indemnification is not timely made, Indemnitee
        may
        seek an adjudication in an appropriate court of the State of Delaware or
        New
        Jersey of Indemnitee's entitlement to indemnification or advancement of
        Expenses. The Company is precluded from asserting in any judicial proceeding
        that the procedures and presumptions of the Agreement are not valid, binding
        and
        enforceable and the Company must stipulate that the Company is bound by all
        the
        provisions of the Agreement. If the Indemnitee seeks a judicial adjudication
        of
        Indemnitee's rights under, or to recover damages for breach of, the Agreement,
        Indemnitee will be entitled to recover all Expenses, but only for the issues
        on
        which Indemnitee prevails.
To
        the
        extent that the Company maintains an insurance policy providing liability
        insurance for directors, officers, employees, agents or fiduciaries of the
        Company, Indemnitee will be covered by such policy in accordance with its
        terms
        to the maximum extent of the coverage available for any director, officer,
        employee, agent or fiduciary. The Company is not liable to make any payment
        otherwise indemnifiable under the Agreement if and to the extent that Indemnitee
        has received payment under any insurance policy, contract, agreement or
        otherwise.
The
        Agreement terminates upon the later of: (a) ten years after the date
        that
        Indemnitee ceases to serve as a director, officer, employee, agent or fiduciary
        of the Company; or (b) the final termination of all pending Proceedings
        and
        of any proceeding commenced by Indemnitee.
Item
                      5.02.
Departure
                      of Directors or Principal Officers; Election of Directors;
                      Appointment of
                      Principal Officers.
On
        November 15, 2005, the Chairman of the Board of Directors of Columbia
        Laboratories, Inc., (the "Company") received a letter from Robert C. Strauss, a
        Director of the Company, notifying him that Mr. Strauss will retire from
        the
        Company's Board of Directors effective December 31, 2005. Mr. Strauss will
        continue as a member of the Board of Directors, and will continue as chair
        of
        the Company's Audit Committee and as a member of the Compensation Committee
        until December 31, 2005.
SIGNATURE
Pursuant
        to the requirements of the Securities Exchange Act of 1934, the registrant
        has
        duly caused this report to be signed on its behalf by the undersigned hereunto
        duly authorized.
Date: November 16, 2005
COLUMBIA
                LABORATORIES, INC.
By:
/s/ David
                L. Weinberg
David L. Weinberg
Vice President and Chief Financial Officer