UNITED STATES
                       SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549

                                    FORM 8-K

                                 CURRENT REPORT
     Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934


                                 August 29, 2005

                Date of Report (Date of earliest event reported)


                                 ORAGENICS, INC.

             (Exact name of registrant as specified in its charter)


           Florida                       000-50614               59-3410522
----------------------------           ------------          -------------------
(State or other jurisdiction           (Commission             (IRS Employer
      of incorporation)                File Number)          Identification No.)


                            13700 Progress Boulevard
                             Alachua, Florida 32653

           (Address of principal executive offices including zip code)


                                 (386) 418-4018

               Registrant's telephone number, including area code

--------------------------------------------------------------------------------

                                      None
--------------------------------------------------------------------------------

         (Former name or former address, if changed since last report.)
--------------------------------------------------------------------------------
<PAGE>

Item 4.1    Changes in Registrant's Certifying  Accountants

      (a)   Dismissal of Previous Independent Registered Public Accounting Firm

            (i) On August 26, 2005 the Audit Committee of the Board of Directors
      of Oragenics, Inc. ("the Company"), dismissed Ernst & Young LLP as the
      Company's independent registered public accounting firm.

            (ii) The reports of Ernst & Young LLP on the Company's financial
      statements as of and for the years ended December 31, 2003 and 2004, did
      not contain an adverse opinion or a disclaimer of opinion as to audit
      scope or accounting principles. The report of Ernst & Young LLP on the
      Company's financial statements as of and for the year ended December 31,
      2004 was modified for a going concern uncertainty.

            (iii) During the Company's two most recent fiscal years ended
      December 31, 2003 and 2004, and the subsequent interim period from January
      1, 2005 through August 26, 2005, there were no disagreements with Ernst &
      Young LLP on any matters of accounting principles or practices, financial
      statement disclosure, or auditing scope and procedures which, if not
      resolved to the satisfaction of Ernst & Young LLP would have caused Ernst
      & Young LLP to make reference to the matter in their report.

            (iv) The Company has requested Ernst & Young LLP to furnish it with
      a letter addressed to the Commission stating whether it agrees with the
      above statements. A copy of that letter, dated August 29, 2005, is filed
      as Exhibit 16 to this Form 8-K.

      (b)   Engagement of New Independent Registered Public Accounting Firm

            (i)   On August 26, 2005, the Audit Committee of the Company's Board
                  of Directors approved the engagement of Kirkland, Russ, Murphy
                  and Tapp as the Company's independent registered public
                  accounting firm for the year ending December 31, 2005. Prior
                  to the dismissal of Ernst & Young LLP, the Company did not
                  consult with Kirkland, Russ, Murphy and Tapp regarding: (i)
                  the application of accounting principles to a specified
                  transaction, either completed or proposed; or (ii) the type of
                  audit opinion that might be rendered on the Company's
                  financial statement.


ITEM 9.1   Financial Statements and Exhibits

      (c)     Exhibits

      16      Letter of Ernst & Young LLP dated August 29, 2005
      99.1    Press release dated August 29, 2005

      Pursuant to the requirements of the Securities Exchange Act of 1934, the
registrant has duly caused this report to be signed on its behalf by the
undersigned thereunto duly authorized.



Oragenics, Inc.




/s/ Paul Hassie
-----------------------
Paul Hassie
Chief Financial Officer


Dated: August 29, 2005
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UNITED STATES
                       SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549

                                    FORM 8-K

                                 CURRENT REPORT
     Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934

                                 August 29, 2005

                Date of Report (Date of earliest event reported)

                                 ORAGENICS, INC.

             (Exact name of registrant as specified in its charter)

           Florida                       000-50614               59-3410522
----------------------------           ------------          -------------------
(State or other jurisdiction           (Commission             (IRS Employer
      of incorporation)                File Number)          Identification No.)

                            13700 Progress Boulevard
                             Alachua, Florida 32653

           (Address of principal executive offices including zip code)

                                 (386) 418-4018

               Registrant's telephone number, including area code

--------------------------------------------------------------------------------

                                      None
--------------------------------------------------------------------------------

         (Former name or former address, if changed since last report.)
--------------------------------------------------------------------------------
Item 4.1    Changes in Registrant's Certifying  Accountants

      (a)   Dismissal of Previous Independent Registered Public Accounting Firm

            (i) On August 26, 2005 the Audit Committee of the Board of Directors
      of Oragenics, Inc. ("the Company"), dismissed Ernst & Young LLP as the
      Company's independent registered public accounting firm.

            (ii) The reports of Ernst & Young LLP on the Company's financial
      statements as of and for the years ended December 31, 2003 and 2004, did
      not contain an adverse opinion or a disclaimer of opinion as to audit
      scope or accounting principles. The report of Ernst & Young LLP on the
      Company's financial statements as of and for the year ended December 31,
      2004 was modified for a going concern uncertainty.

            (iii) During the Company's two most recent fiscal years ended
      December 31, 2003 and 2004, and the subsequent interim period from January
      1, 2005 through August 26, 2005, there were no disagreements with Ernst &
      Young LLP on any matters of accounting principles or practices, financial
      statement disclosure, or auditing scope and procedures which, if not
      resolved to the satisfaction of Ernst & Young LLP would have caused Ernst
      & Young LLP to make reference to the matter in their report.

            (iv) The Company has requested Ernst & Young LLP to furnish it with
      a letter addressed to the Commission stating whether it agrees with the
      above statements. A copy of that letter, dated August 29, 2005, is filed
      as Exhibit 16 to this Form 8-K.

      (b)   Engagement of New Independent Registered Public Accounting Firm

            (i)   On August 26, 2005, the Audit Committee of the Company's Board
                  of Directors approved the engagement of Kirkland, Russ, Murphy
                  and Tapp as the Company's independent registered public
                  accounting firm for the year ending December 31, 2005. Prior
                  to the dismissal of Ernst & Young LLP, the Company did not
                  consult with Kirkland, Russ, Murphy and Tapp regarding: (i)
                  the application of accounting principles to a specified
                  transaction, either completed or proposed; or (ii) the type of
                  audit opinion that might be rendered on the Company's
                  financial statement.

ITEM 9.1   Financial Statements and Exhibits

      (c)     Exhibits

      16      Letter of Ernst & Young LLP dated August 29, 2005
      99.1    Press release dated August 29, 2005

      Pursuant to the requirements of the Securities Exchange Act of 1934, the
registrant has duly caused this report to be signed on its behalf by the
undersigned thereunto duly authorized.

Oragenics, Inc.

/s/ Paul Hassie
-----------------------
Paul Hassie
Chief Financial Officer

Dated: August 29, 2005