<PAGE>   1

                                   The Registrant requests effectiveness of this
                                Registration Statement upon filing in accordance
                                                               with Rule 462(a).

     As filed with the Securities & Exchange Commission on January 26, 2001
                                                  Registration No. 33-
                                                                      ----------
================================================================================

                       SECURITIES AND EXCHANGE COMMISSION
                             WASHINGTON, D.C. 20549

                            -------------------------

                                    FORM S-8

                             REGISTRATION STATEMENT
                                    UNDER THE
                             SECURITIES ACT OF 1933

                            -------------------------

                                 CHRONIMED INC.
             ------------------------------------------------------
             (Exact name of registrant as specified in its charter)

              Minnesota                                 41-1515691
    ---------------------------------               -------------------
      (State or other jurisdiction                   (I.R.S. Employer
    of incorporation or organization)               Identification No.)

                            -------------------------

                             10900 RED CIRCLE DRIVE
                           MINNETONKA, MINNESOTA 55343
                                 (612) 979-3600
          ------------------------------------------------------------
          (Address and telephone number of principal executive offices)

                            -------------------------

                    CHRONIMED INC. 2001 STOCK INCENTIVE PLAN
                    ----------------------------------------
                            (Full title of the Plan)

                              Henry F. Blissenbach
                             10900 Red Circle Drive
                           Minnetonka, Minnesota 55343
                                 (952) 979-3600
            ---------------------------------------------------------
            (Name, address and telephone number of agent for service)

                            -------------------------

               Approximate date of proposed commencement of sales
               pursuant to the Plan: From time to time after this
                    Registration Statement becomes effective.

                            -------------------------

                         CALCULATION OF REGISTRATION FEE
<TABLE>
<CAPTION>
====================================================================================================================================
         Title of                 Amount                Proposed maximum                  Proposed maximum               Amount of
      securities to                to be                 offering price                  aggregate offering            registration
      be registered             registered              per share (1)(2)                    price (1)(2)                  fee (2)
------------------------------------------------------------------------------------------------------------------------------------
<S>                             <C>                     <C>                              <C>                           <C>
Common Stock,                    1,000,000                   $10.594                         $10,594,000                 $2,648.50
   par value $.01
====================================================================================================================================
</TABLE>

(1)      Consists of an aggregate of 1,000,000 shares of Common Stock that may
         be optioned or awarded and sold under one or more offerings to be made
         from time to time under the Chronimed Inc. 2001 Stock Incentive Plan
         (the "Plan"). Pursuant to Rule 416 under the Securities Act of 1933,
         this registration statement also covers an indeterminate number of
         shares which may be offered or sold pursuant to the Plan as a result of
         the operation of the provisions of the Plan intended to prevent
         dilution in the event of stock splits, consolidations or similar
         changes in capital stock.

(2)      Estimated solely for purposes of computing the registration fee. In
         accordance with Rule 457(c) and (h), the price used is the average of
         the high and low sales prices of the Common Stock in the NASDAQ
         National Market as of January 24, 2001.

================================================================================

<PAGE>   2


                                     PART I

              INFORMATION REQUIRED IN THE SECTION 10(a) PROSPECTUS


         Pursuant to Rule 428(b)(1) under the Securities Act of 1933, as
amended, the document containing the information specified in Part I of Form S-8
will be distributed to persons who receive options or awards under the Chronimed
Inc. 2001 Stock Incentive Plan (the "Plan").


                                     PART II

               INFORMATION REQUIRED IN THE REGISTRATION STATEMENT


ITEM 3.  INCORPORATION OF DOCUMENTS BY REFERENCE

         The Company is subject to the information requirements of the
Securities Exchange Act of 1934, as amended ("Exchange Act"), and, in accordance
therewith, files reports and other information with the Securities and Exchange
Commission ("Commission"). The following documents, which have been filed by the
Company with the Commission pursuant to the Exchange Act (File No. 0-19952), are
incorporated by reference in this registration statement:

                  (a) The Company's Annual Report on Form 10-K for the year
         ended June 30, 2000;

                  (b) All other reports and documents filed by the Company under
         Sections 13(a) or 15(d) of the Securities Exchange Act of 1934, as
         amended ("Exchange Act") since the filing of the most recent Annual
         Report on Form 10-K; and

                  (c) The description of the Company's stock contained in the
         Company's Registration Statement on Form 8-A declared effective by the
         Commission as of March 19, 1992.

         All documents subsequently filed by the Company with the Commission
pursuant to Sections 13(a), 13(c), 14 and 15(d) of the Exchange Act, prior to
the filing of a post-effective amendment that indicates that all securities
offered have been sold or that deregisters all securities then remaining unsold,
shall be deemed to be incorporated by reference herein and to be a part hereof
from the date of filing such documents.

ITEM 4.  DESCRIPTION OF SECURITIES

         The class of securities to be offered under the Plan is registered
under Section 12 of the Exchange Act.


                                       2
<PAGE>   3


ITEM 5.  INTERESTS OF NAMED EXPERTS AND COUNSEL

         The validity of the newly issued securities offered pursuant to this
Registration Statement will be passed upon by Gray, Plant, Mooty, Mooty &
Bennett, P.A., counsel to the Company.

         As of January 24, 2001, attorneys in the law firm of Gray, Plant,
Mooty, Mooty & Bennett, P.A. beneficially owned an aggregate of approximately
$162,088 worth of common stock of the Company.

ITEM 6.  INDEMNIFICATION OF DIRECTORS AND OFFICERS

         Minnesota Statutes, Section 302A.521 provides that a Minnesota business
corporation may indemnify any director, officer, employee or other
representative of the corporation made or threatened to be made a party to a
proceeding, by reason of the former or present official capacity (as defined) of
the person, against judgments, penalties, fines, settlements and reasonable
expenses incurred by the person in connection with the proceeding if certain
statutory standards are met. "Proceeding" means a threatened, pending or
completed civil, criminal, administrative, arbitration or investigative
proceeding, including one by or in the right of the corporation. Section
302A.521 contains detailed terms regarding such right of indemnification and
reference is made thereto for a complete statement of such indemnification
rights.

         In addition, Article VII of the Company's Articles of Incorporation
eliminates certain personal liability of the directors of the Company for
monetary damages for certain breaches of directors' fiduciary duties as
permitted by Minnesota Statutes, Section 302A.251. Indemnification Agreements
between the Company and each of its directors and officers provide for
indemnification to the fullest extent allowed under Minnesota law.

ITEM 7.  EXEMPTION FROM REGISTRATION CLAIMED

         Not applicable.


ITEM 8.  EXHIBITS

Exhibit No.                       Description
-----------                       -----------

4.1            Specimen Form of Common Stock Certificate (1)

4.2            Chronimed Inc. 2001 Stock Incentive Plan (2)

5.1            Opinion of Gray, Plant, Mooty, Mooty & Bennett, P.A.

23.1           Consent of Ernst & Young LLP

23.2           Consent of Gray, Plant, Mooty, Mooty & Bennett, P.A. (contained
               in Exhibit 5.1 of this Registration Statement).


                                       3
<PAGE>   4



24.1           Powers of Attorney (included on the signature page of this
               Registration Statement).

--------------------

(1)      Incorporated by reference to the exhibits filed with the Company's
         Registration Statement filed on Form S-1 (Reg. No. 33-45644).

(2)      Incorporated by reference to Exhibit A to the Company's Definitive
         Proxy Statement, filed on Schedule 14A, October 13, 2000.

ITEM 9. UNDERTAKINGS

         (a)      Rule 415 Offering.

         The undersigned registrant hereby undertakes:

         (1) To file, during any period in which offers or sales are being made,
a post-effective amendment to this Registration Statement:

                  (i) To include any prospectus required by Section 10(a)(3) of
         the Securities Act of 1933;

                  (ii) To reflect in the prospectus any facts or events arising
         after the effective date of the Registration Statement (or the most
         recent post-effective amendment thereof) which, individually or in the
         aggregate, represent a fundamental change in the information set forth
         in the Registration Statement;

                  (iii) To include any material information with respect to the
         plan of distribution not previously disclosed in the Registration or
         any material change to such information in the Registration Statement;

         Provided, however, that paragraphs (a)(1)(i) and (a)(1)(ii) do not
apply if the information required to be included in the post-effective amendment
by those paragraphs is contained in periodic reports filed by the Registrant
pursuant to Section 13 or Section 15(d) of the Securities Exchange Act of 1934
that are incorporated by reference in the Registration Statement.

         (2) That, for the purpose of determining any liability under the
Securities Act of 1933, each such post-effective amendment shall be deemed to be
a new registration statement relating to the securities offered therein, and the
offering of such securities at that time shall be deemed to be the initial bona
fide offering thereof.

         (3) To remove from registration by means of a post-effective amendment
any of the securities being registered which remain unsold at the termination of
the offering.

         (b) Filings Incorporating Subsequent Exchange Act Documents by
Reference.


                                       4
<PAGE>   5


         The undersigned registrant hereby undertakes that, for purposes of
determining any liability under the Securities Act of 1933, each filing of the
Registrant's annual report pursuant to Section 13(a) or Section 15(d) of the
Securities Exchange Act of 1934 that is incorporated by reference in the
Registration Statement shall be deemed to be a new registration statement
relating to the securities offered therein, and the offering of such securities
at that time shall be deemed to be the initial bona fide offering thereof.

         (h) Request for Acceleration of Effective Date or Filing of
Registration Statement on Form S-8.

         Insofar as indemnification for liabilities arising under the Securities
Act of 1933 may be permitted to directors, officers and controlling persons of
the registrant pursuant to the foregoing provisions, or otherwise, the
registrant has been advised that in the opinion of the Securities and Exchange
Commission such indemnification is against public policy as expressed in the Act
and is, therefore, unenforceable. In the event that a claim for indemnification
against such liabilities (other than the payment by the registrant of expenses
incurred or paid by a director, officer or controlling person of the registrant
in the successful defense of any action, suit or proceeding) is asserted by such
director, officer or controlling person in connection with the securities being
registered, the registrant will, unless in the opinion of its counsel the matter
has been settled by controlling precedent, submit to a court of appropriate
jurisdiction the question whether such indemnification by it is against public
policy as expressed in the Act and will be governed by the final adjudication of
such issue.


                                       5
<PAGE>   6


                                   SIGNATURES


         Pursuant to the requirements of the Securities Act of 1933, the
registrant certifies that it has reasonable grounds to believe that it meets all
of the requirements for filing on Form S-8 and has duly caused this registration
statement to be signed on its behalf by the undersigned, thereunto duly
authorized, in the City of Minneapolis, State of Minnesota, on this 26 day of
January, 2001.

                                       CHRONIMED INC.


                                       By  /s/ Henry F. Blissenbach
                                         ---------------------------------------
                                           Henry F. Blissenbach
                                           Chief Executive Officer


                               POWER OF ATTORNEY

         KNOW ALL MEN BY THESE PRESENTS, that each person whose signature
appears below constitutes and appoints Henry F. Blissenbach and Gregory H.
Keane, and each or either one of them, his true and lawful attorney-in-fact and
agent, each acting alone, with full powers of substitution and resubstitution,
for him and in his name, place, and stead, in any and all capacities, to sign
any or all amendments (including post-effective amendments) and supplements to
this Registration Statement, and to file the same, with all exhibits thereto,
and other documents in connection therewith, with the Securities and Exchange
Commission, granting unto said attorneys-in-fact and agents, each acting alone,
full power and authority to do and perform each and every act and thing
requisite or necessary to be done in and about the premises, as fully to all
intents and purposes as he might or could do in person, hereby ratifying and
confirming all that said attorneys-in-fact and agents, each acting alone, or his
substitute or substitutes, may lawfully do or cause to be done by virtue hereof.

         Pursuant to the requirements of the Securities Act of 1933, this
registration statement has been signed below by the following persons in the
capacities and on the dates indicated.

<TABLE>
<CAPTION>
      Signature                                    Capacity                                      Date
      ---------                                    --------                                      ----
<S>                                         <C>                                            <C>
/s/ Henry F. Blissenbach                    Chief Executive Officer                        January 26, 2001
--------------------------------------      (Principal Executive Officer) and
Henry F. Blissenbach                        Chairman


/s/ Gregory H. Keane                        Vice President and Chief Financial             January 26, 2001
--------------------------------------      Officer (Principal Financial and
Gregory H. Keane                            Accounting Officer)
</TABLE>



                                       6
<PAGE>   7


<TABLE>
<S>                                         <C>                                            <C>
/s/ John Howell Bullion                     Director                                       January 26, 2001
--------------------------------------
John Howell Bullion


/s/ John H. Flittie                         Director                                       January 26, 2001
--------------------------------------
John H. Flittie


/s/ Charles V. Owens, Jr.                   Director                                       January 26, 2001
--------------------------------------
Charles V. Owens, Jr.


/s/ Stuart A. Samuels                       Director                                       January 26, 2001
--------------------------------------
Stuart A. Samuels


/s/ David R. Hubers                         Director                                       January 26, 2001
--------------------------------------
David R. Hubers


/s/ Thomas F. Heaney                        Director                                       January 26, 2001
--------------------------------------
Thomas F. Heaney
</TABLE>


                                       7
<PAGE>   8


                                INDEX TO EXHIBITS


EXHIBIT                                                                     PAGE
-------                                                                     ----

 4.1     Specimen Form of Common Stock Certificate(1)                       --

 4.2     Chronimed Inc. 2001 Stock Incentive Plan(2)                        --

 5.1     Opinion of Gray, Plant, Mooty, Mooty & Bennett, P.A.

23.1     Consent of Ernst & Young LLP

23.2     Consent of Gray, Plant, Mooty, Mooty & Bennett, P.A.
         (Exhibit 5.1 to this Registration Statement)

24.1     Power of Attorney (included on the signature page of this
         Registration Statement)                                             7

-------------------

(1)      Incorporated by reference to the Company's Registration Statement filed
         on Form S-1 (Reg. No. 33-45644).

(2)      Incorporated by reference to Exhibit A to the Company's Definitive
         Proxy Statement, filed on Schedule 14A, October 13, 2000.


                                       8
[{"type": "S-8", "sequence": "1", "filename": "c59728s-8.txt", "description": "FORM S-8", "secsgml_size_bytes": 18971}]
{"company-data": {"conformed-name": "CHRONIMED INC", "cik": "0000883813", "assigned-sic": "5961", "irs-number": "411515691", "state-of-incorporation": "MN", "fiscal-year-end": "0630"}, "filing-values": {"form-type": "S-8", "act": "33", "file-number": "333-54348", "film-number": "1515622"}, "business-address": {"street1": "10900 RED CIRCLE DRIVE", "city": "MINNETONKA", "state": "MN", "zip": "55343", "phone": "9529793600"}, "mail-address": {"street1": "10900 RED CIRCLE DRIVE", "city": "MINNETONKA", "state": "MN", "zip": "55343"}}
1

                                   The Registrant requests effectiveness of this
                                Registration Statement upon filing in accordance
                                                               with Rule 462(a).

     As filed with the Securities & Exchange Commission on January 26, 2001
                                                  Registration No. 33-
                                                                      ----------
================================================================================

                       SECURITIES AND EXCHANGE COMMISSION
                             WASHINGTON, D.C. 20549

                            -------------------------

                                    FORM S-8

                             REGISTRATION STATEMENT
                                    UNDER THE
                             SECURITIES ACT OF 1933

                            -------------------------

                                 CHRONIMED INC.
             ------------------------------------------------------
             (Exact name of registrant as specified in its charter)

              Minnesota                                 41-1515691
    ---------------------------------               -------------------
      (State or other jurisdiction                   (I.R.S. Employer
    of incorporation or organization)               Identification No.)

                            -------------------------

                             10900 RED CIRCLE DRIVE
                           MINNETONKA, MINNESOTA 55343
                                 (612) 979-3600
          ------------------------------------------------------------
          (Address and telephone number of principal executive offices)

                            -------------------------

                    CHRONIMED INC. 2001 STOCK INCENTIVE PLAN
                    ----------------------------------------
                            (Full title of the Plan)

                              Henry F. Blissenbach
                             10900 Red Circle Drive
                           Minnetonka, Minnesota 55343
                                 (952) 979-3600
            ---------------------------------------------------------
            (Name, address and telephone number of agent for service)

                            -------------------------

               Approximate date of proposed commencement of sales
               pursuant to the Plan: From time to time after this
                    Registration Statement becomes effective.

                            -------------------------

                         CALCULATION OF REGISTRATION FEE
====================================================================================================================================
         Title of                 Amount                Proposed maximum                  Proposed maximum               Amount of
      securities to                to be                 offering price                  aggregate offering            registration
      be registered             registered              per share (1)(2)                    price (1)(2)                  fee (2)
------------------------------------------------------------------------------------------------------------------------------------
Common Stock,                    1,000,000                   $10.594                         $10,594,000                 $2,648.50
   par value $.01
====================================================================================================================================
(1)      Consists of an aggregate of 1,000,000 shares of Common Stock that may
         be optioned or awarded and sold under one or more offerings to be made
         from time to time under the Chronimed Inc. 2001 Stock Incentive Plan
         (the "Plan"). Pursuant to Rule 416 under the Securities Act of 1933,
         this registration statement also covers an indeterminate number of
         shares which may be offered or sold pursuant to the Plan as a result of
         the operation of the provisions of the Plan intended to prevent
         dilution in the event of stock splits, consolidations or similar
         changes in capital stock.

(2)      Estimated solely for purposes of computing the registration fee. In
         accordance with Rule 457(c) and (h), the price used is the average of
         the high and low sales prices of the Common Stock in the NASDAQ
         National Market as of January 24, 2001.

================================================================================
2

                                     PART I

              INFORMATION REQUIRED IN THE SECTION 10(a) PROSPECTUS

         Pursuant to Rule 428(b)(1) under the Securities Act of 1933, as
amended, the document containing the information specified in Part I of Form S-8
will be distributed to persons who receive options or awards under the Chronimed
Inc. 2001 Stock Incentive Plan (the "Plan").

                                     PART II

               INFORMATION REQUIRED IN THE REGISTRATION STATEMENT

ITEM 3.  INCORPORATION OF DOCUMENTS BY REFERENCE

         The Company is subject to the information requirements of the
Securities Exchange Act of 1934, as amended ("Exchange Act"), and, in accordance
therewith, files reports and other information with the Securities and Exchange
Commission ("Commission"). The following documents, which have been filed by the
Company with the Commission pursuant to the Exchange Act (File No. 0-19952), are
incorporated by reference in this registration statement:

                  (a) The Company's Annual Report on Form 10-K for the year
         ended June 30, 2000;

                  (b) All other reports and documents filed by the Company under
         Sections 13(a) or 15(d) of the Securities Exchange Act of 1934, as
         amended ("Exchange Act") since the filing of the most recent Annual
         Report on Form 10-K; and

                  (c) The description of the Company's stock contained in the
         Company's Registration Statement on Form 8-A declared effective by the
         Commission as of March 19, 1992.

         All documents subsequently filed by the Company with the Commission
pursuant to Sections 13(a), 13(c), 14 and 15(d) of the Exchange Act, prior to
the filing of a post-effective amendment that indicates that all securities
offered have been sold or that deregisters all securities then remaining unsold,
shall be deemed to be incorporated by reference herein and to be a part hereof
from the date of filing such documents.

ITEM 4.  DESCRIPTION OF SECURITIES

         The class of securities to be offered under the Plan is registered
under Section 12 of the Exchange Act.

                                       2
3

ITEM 5.  INTERESTS OF NAMED EXPERTS AND COUNSEL

         The validity of the newly issued securities offered pursuant to this
Registration Statement will be passed upon by Gray, Plant, Mooty, Mooty &
Bennett, P.A., counsel to the Company.

         As of January 24, 2001, attorneys in the law firm of Gray, Plant,
Mooty, Mooty & Bennett, P.A. beneficially owned an aggregate of approximately
$162,088 worth of common stock of the Company.

ITEM 6.  INDEMNIFICATION OF DIRECTORS AND OFFICERS

         Minnesota Statutes, Section 302A.521 provides that a Minnesota business
corporation may indemnify any director, officer, employee or other
representative of the corporation made or threatened to be made a party to a
proceeding, by reason of the former or present official capacity (as defined) of
the person, against judgments, penalties, fines, settlements and reasonable
expenses incurred by the person in connection with the proceeding if certain
statutory standards are met. "Proceeding" means a threatened, pending or
completed civil, criminal, administrative, arbitration or investigative
proceeding, including one by or in the right of the corporation. Section
302A.521 contains detailed terms regarding such right of indemnification and
reference is made thereto for a complete statement of such indemnification
rights.

         In addition, Article VII of the Company's Articles of Incorporation
eliminates certain personal liability of the directors of the Company for
monetary damages for certain breaches of directors' fiduciary duties as
permitted by Minnesota Statutes, Section 302A.251. Indemnification Agreements
between the Company and each of its directors and officers provide for
indemnification to the fullest extent allowed under Minnesota law.

ITEM 7.  EXEMPTION FROM REGISTRATION CLAIMED

         Not applicable.

ITEM 8.  EXHIBITS

Exhibit No.                       Description
-----------                       -----------

4.1            Specimen Form of Common Stock Certificate (1)

4.2            Chronimed Inc. 2001 Stock Incentive Plan (2)

5.1            Opinion of Gray, Plant, Mooty, Mooty & Bennett, P.A.

23.1           Consent of Ernst & Young LLP

23.2           Consent of Gray, Plant, Mooty, Mooty & Bennett, P.A. (contained
               in Exhibit 5.1 of this Registration Statement).

                                       3
4

24.1           Powers of Attorney (included on the signature page of this
               Registration Statement).

--------------------

(1)      Incorporated by reference to the exhibits filed with the Company's
         Registration Statement filed on Form S-1 (Reg. No. 33-45644).

(2)      Incorporated by reference to Exhibit A to the Company's Definitive
         Proxy Statement, filed on Schedule 14A, October 13, 2000.

ITEM 9. UNDERTAKINGS

         (a)      Rule 415 Offering.

         The undersigned registrant hereby undertakes:

         (1) To file, during any period in which offers or sales are being made,
a post-effective amendment to this Registration Statement:

                  (i) To include any prospectus required by Section 10(a)(3) of
         the Securities Act of 1933;

                  (ii) To reflect in the prospectus any facts or events arising
         after the effective date of the Registration Statement (or the most
         recent post-effective amendment thereof) which, individually or in the
         aggregate, represent a fundamental change in the information set forth
         in the Registration Statement;

                  (iii) To include any material information with respect to the
         plan of distribution not previously disclosed in the Registration or
         any material change to such information in the Registration Statement;

         Provided, however, that paragraphs (a)(1)(i) and (a)(1)(ii) do not
apply if the information required to be included in the post-effective amendment
by those paragraphs is contained in periodic reports filed by the Registrant
pursuant to Section 13 or Section 15(d) of the Securities Exchange Act of 1934
that are incorporated by reference in the Registration Statement.

         (2) That, for the purpose of determining any liability under the
Securities Act of 1933, each such post-effective amendment shall be deemed to be
a new registration statement relating to the securities offered therein, and the
offering of such securities at that time shall be deemed to be the initial bona
fide offering thereof.

         (3) To remove from registration by means of a post-effective amendment
any of the securities being registered which remain unsold at the termination of
the offering.

         (b) Filings Incorporating Subsequent Exchange Act Documents by
Reference.

                                       4
5

         The undersigned registrant hereby undertakes that, for purposes of
determining any liability under the Securities Act of 1933, each filing of the
Registrant's annual report pursuant to Section 13(a) or Section 15(d) of the
Securities Exchange Act of 1934 that is incorporated by reference in the
Registration Statement shall be deemed to be a new registration statement
relating to the securities offered therein, and the offering of such securities
at that time shall be deemed to be the initial bona fide offering thereof.

         (h) Request for Acceleration of Effective Date or Filing of
Registration Statement on Form S-8.

         Insofar as indemnification for liabilities arising under the Securities
Act of 1933 may be permitted to directors, officers and controlling persons of
the registrant pursuant to the foregoing provisions, or otherwise, the
registrant has been advised that in the opinion of the Securities and Exchange
Commission such indemnification is against public policy as expressed in the Act
and is, therefore, unenforceable. In the event that a claim for indemnification
against such liabilities (other than the payment by the registrant of expenses
incurred or paid by a director, officer or controlling person of the registrant
in the successful defense of any action, suit or proceeding) is asserted by such
director, officer or controlling person in connection with the securities being
registered, the registrant will, unless in the opinion of its counsel the matter
has been settled by controlling precedent, submit to a court of appropriate
jurisdiction the question whether such indemnification by it is against public
policy as expressed in the Act and will be governed by the final adjudication of
such issue.

                                       5
6

                                   SIGNATURES

         Pursuant to the requirements of the Securities Act of 1933, the
registrant certifies that it has reasonable grounds to believe that it meets all
of the requirements for filing on Form S-8 and has duly caused this registration
statement to be signed on its behalf by the undersigned, thereunto duly
authorized, in the City of Minneapolis, State of Minnesota, on this 26 day of
January, 2001.

                                       CHRONIMED INC.

                                       By  /s/ Henry F. Blissenbach
                                         ---------------------------------------
                                           Henry F. Blissenbach
                                           Chief Executive Officer

                               POWER OF ATTORNEY

         KNOW ALL MEN BY THESE PRESENTS, that each person whose signature
appears below constitutes and appoints Henry F. Blissenbach and Gregory H.
Keane, and each or either one of them, his true and lawful attorney-in-fact and
agent, each acting alone, with full powers of substitution and resubstitution,
for him and in his name, place, and stead, in any and all capacities, to sign
any or all amendments (including post-effective amendments) and supplements to
this Registration Statement, and to file the same, with all exhibits thereto,
and other documents in connection therewith, with the Securities and Exchange
Commission, granting unto said attorneys-in-fact and agents, each acting alone,
full power and authority to do and perform each and every act and thing
requisite or necessary to be done in and about the premises, as fully to all
intents and purposes as he might or could do in person, hereby ratifying and
confirming all that said attorneys-in-fact and agents, each acting alone, or his
substitute or substitutes, may lawfully do or cause to be done by virtue hereof.

         Pursuant to the requirements of the Securities Act of 1933, this
registration statement has been signed below by the following persons in the
capacities and on the dates indicated.
Signature                                    Capacity                                      Date
      ---------                                    --------                                      ----
/s/ Henry F. Blissenbach                    Chief Executive Officer                        January 26, 2001
--------------------------------------      (Principal Executive Officer) and
Henry F. Blissenbach                        Chairman

/s/ Gregory H. Keane                        Vice President and Chief Financial             January 26, 2001
--------------------------------------      Officer (Principal Financial and
Gregory H. Keane                            Accounting Officer)
6
7
/s/ John Howell Bullion                     Director                                       January 26, 2001
--------------------------------------
John Howell Bullion

/s/ John H. Flittie                         Director                                       January 26, 2001
--------------------------------------
John H. Flittie

/s/ Charles V. Owens, Jr.                   Director                                       January 26, 2001
--------------------------------------
Charles V. Owens, Jr.

/s/ Stuart A. Samuels                       Director                                       January 26, 2001
--------------------------------------
Stuart A. Samuels

/s/ David R. Hubers                         Director                                       January 26, 2001
--------------------------------------
David R. Hubers

/s/ Thomas F. Heaney                        Director                                       January 26, 2001
--------------------------------------
Thomas F. Heaney
7
8

                                INDEX TO EXHIBITS

EXHIBIT                                                                     PAGE
-------                                                                     ----

 4.1     Specimen Form of Common Stock Certificate(1)                       --

 4.2     Chronimed Inc. 2001 Stock Incentive Plan(2)                        --

 5.1     Opinion of Gray, Plant, Mooty, Mooty & Bennett, P.A.

23.1     Consent of Ernst & Young LLP

23.2     Consent of Gray, Plant, Mooty, Mooty & Bennett, P.A.
         (Exhibit 5.1 to this Registration Statement)

24.1     Power of Attorney (included on the signature page of this
         Registration Statement)                                             7

-------------------

(1)      Incorporated by reference to the Company's Registration Statement filed
         on Form S-1 (Reg. No. 33-45644).

(2)      Incorporated by reference to Exhibit A to the Company's Definitive
         Proxy Statement, filed on Schedule 14A, October 13, 2000.

                                       8