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<P ALIGN="CENTER"><FONT SIZE=2><B>As filed with the Securities and Exchange Commission on October&nbsp;19, 2001  </B></FONT></P>

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<P ALIGN="CENTER"><FONT SIZE=5><B>SECURITIES AND EXCHANGE COMMISSION<BR>  </B></FONT><FONT SIZE=2><B>Washington, D.C. 20549  </B></FONT></P>

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<P ALIGN="CENTER"><FONT SIZE=5><B>FORM S-8<BR>  </B></FONT><FONT SIZE=2><B>Registration Statement<BR>
Under the Securities Act of 1933  </B></FONT></P>

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<P ALIGN="CENTER"><FONT SIZE=5><B>TRANSGENOMIC,&nbsp;INC.<BR>  </B></FONT><FONT SIZE=2>(Exact name of registrant as specified in its charter) </FONT></P>

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<TD WIDTH="50%" ALIGN="CENTER"><FONT SIZE=2><B>Delaware</B></FONT></TD>
<TD WIDTH="50%" ALIGN="CENTER"><FONT SIZE=2><B>91-1789357</B></FONT></TD>
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<TD WIDTH="50%" ALIGN="CENTER"><FONT SIZE=2>(State or other jurisdiction of<BR>
incorporation or organization)</FONT></TD>
<TD WIDTH="50%" ALIGN="CENTER"><FONT SIZE=2>(I.R.S. Employer<BR>
Identification No.)</FONT></TD>
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<TD WIDTH="50%" ALIGN="CENTER"><BR><FONT SIZE=2><B>12325 Emmet Street, Omaha, NE</B></FONT></TD>
<TD WIDTH="50%" ALIGN="CENTER"><FONT SIZE=2><B><BR>
68164</B></FONT></TD>
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<TD WIDTH="50%" ALIGN="CENTER"><FONT SIZE=2>(Address of principal executive offices)</FONT></TD>
<TD WIDTH="50%" ALIGN="CENTER"><FONT SIZE=2>(Zip code)</FONT></TD>
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<P ALIGN="CENTER"><FONT SIZE=3><B>TRANSGENOMIC,&nbsp;INC.<BR>
SECOND AMENDED AND RESTATED 2001 EMPLOYEE STOCK PURCHASE PLAN<BR>  </B></FONT><FONT SIZE=2>(Full title of the plan) </FONT></P>

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<TD WIDTH="50%" ALIGN="CENTER"><FONT SIZE=2><B>Collin J. D'Silva<BR>
Chairman and Chief Executive Officer<BR>
Transgenomic, Inc.<BR>
12325 Emmet Street,<BR>
Omaha, NE 68164</B></FONT></TD>
<TD WIDTH="50%" ALIGN="CENTER"><FONT SIZE=2><B>(402) 452-5400</B></FONT></TD>
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<TD WIDTH="50%" ALIGN="CENTER"><FONT SIZE=2>(Name and address of agent for service)</FONT></TD>
<TD WIDTH="50%" ALIGN="CENTER"><FONT SIZE=2>(Telephone number, including area<BR>
code, of agent for service)</FONT></TD>
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<P ALIGN="CENTER"><FONT SIZE=2>
Copies to:<BR></FONT> <FONT SIZE=2><B>Steven P. Amen, Esq.<BR>
Kutak Rock LLP<BR>
1650 Farnam Street<BR>
Omaha, Nebraska 68102<BR>
(402)&nbsp;346-6000  </B></FONT></P>

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<P ALIGN="CENTER"><FONT SIZE=2><B> CALCULATION OF REGISTRATION FEE  </B></FONT></P>

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<TH WIDTH="35%" ALIGN="CENTER"><FONT SIZE=1><B>Title of Securities to be Registered<BR> </B></FONT><BR></TH>
<TH WIDTH="1%"><FONT SIZE=1>&nbsp;</FONT></TH>
<TH WIDTH="18%" ALIGN="CENTER"><FONT SIZE=1><B>Amount to Be Registered(1)<BR> </B></FONT><BR></TH>
<TH WIDTH="1%"><FONT SIZE=1>&nbsp;</FONT></TH>
<TH WIDTH="15%" ALIGN="CENTER"><FONT SIZE=1><B>Proposed Maximum Offering Price Per Share(2)<BR> </B></FONT><BR></TH>
<TH WIDTH="1%"><FONT SIZE=1>&nbsp;</FONT></TH>
<TH WIDTH="15%" ALIGN="CENTER"><FONT SIZE=1><B>Proposed Maximum Aggregate Offering Price<BR> </B></FONT><BR></TH>
<TH WIDTH="1%"><FONT SIZE=1>&nbsp;</FONT></TH>
<TH WIDTH="15%" ALIGN="CENTER"><FONT SIZE=1><B>Amount of Registration Fee<BR> </B></FONT><BR></TH>
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<TD WIDTH="35%"><FONT SIZE=2>Common Stock, par value $0.01 per share</FONT></TD>
<TD WIDTH="1%"><FONT SIZE=2>&nbsp;</FONT></TD>
<TD WIDTH="18%" ALIGN="CENTER"><FONT SIZE=2>500,000 shares</FONT></TD>
<TD WIDTH="1%"><FONT SIZE=2>&nbsp;</FONT></TD>
<TD WIDTH="15%" ALIGN="CENTER"><FONT SIZE=2>$8.35</FONT></TD>
<TD WIDTH="1%"><FONT SIZE=2>&nbsp;</FONT></TD>
<TD WIDTH="15%" ALIGN="CENTER"><FONT SIZE=2>$4,175,000</FONT></TD>
<TD WIDTH="1%"><FONT SIZE=2>&nbsp;</FONT></TD>
<TD WIDTH="15%" ALIGN="CENTER"><FONT SIZE=2>$1,043.75</FONT></TD>
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<DL compact>
<DT><FONT SIZE=2>(1)</FONT></DT><DD><FONT SIZE=2>This
Registration Statement shall also cover any additional shares of Registrant's common stock which become issuable under the Second Amended and Restated 2001 Employee Stock
Purchase Plan, as amended from time to time, with respect to the securities registered hereunder by reason of any stock dividend, stock split, recapitalization or other similar transaction effected
without the Registrant's receipt of consideration which results in an increase in the number of the Registrant's outstanding shares of common stock.
<BR><BR></FONT></DD><DT><FONT SIZE=2>(2)</FONT></DT><DD><FONT SIZE=2>Estimated
pursuant to Rule&nbsp;457(c) and (h)&nbsp;solely for purposes of calculating the registration fee. The price per share is estimated to be $8.35 based on the average of
the high ($9.00) and low ($7.69) sale prices for the Common Stock as reported by the Nasdaq National Market on October&nbsp;12, 2001. </FONT></DD></DL>
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<BR></FONT><FONT SIZE=2><B>PART I<BR>  <BR>    INFORMATION REQUIRED IN THE<BR>  Section&nbsp;10(a) PROSPECTUS    <BR>  </B></FONT></P>

<P><FONT SIZE=2><A
NAME="ja4574_item_1._plan_information"> </A>
<A NAME="toc_ja4574_2"> </A></FONT> <FONT SIZE=2><B>Item 1.&nbsp;&nbsp;</B></FONT><FONT SIZE=2><I>Plan Information</I></FONT></P>

<P><FONT SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;Information
required by Part&nbsp;I of Form&nbsp;S-8 to be contained in the Section&nbsp;10(a) prospectus is omitted from this registration statement in accordance
with Rule&nbsp;428 under the Securities Act of 1933, as amended ("Securities Act") and the Note to Part&nbsp;I of Form&nbsp;S-8. </FONT></P>


<P><FONT SIZE=2><A
NAME="ja4574_item_2._registration_informati__ite02707"> </A>
<A NAME="toc_ja4574_3"> </A>
<BR></FONT><FONT SIZE=2><B>Item 2.&nbsp;&nbsp;</B></FONT><FONT SIZE=2><I>Registration Information and Employee Plan Annual Information.</I></FONT></P>

<P><FONT SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;Information
required by Part&nbsp;I of Form&nbsp;S-8 to be contained in the Section&nbsp;10(a) prospectus is omitted from this registration statement in accordance
with Rule&nbsp;428 under the Securities Act and the Note to Part&nbsp;I of Form&nbsp;S-8. </FONT></P>

<P ALIGN="CENTER"><FONT SIZE=2><A
NAME="ja4574_part_ii_information_req__ja402478"> </A>
<A NAME="toc_ja4574_4"> </A>
<BR></FONT><FONT SIZE=2><B>PART II<BR>  <BR>    INFORMATION REQUIRED IN THE REGISTRATION STATEMENT    <BR>  </B></FONT></P>

<P><FONT SIZE=2><A
NAME="ja4574_item_3._incorporation_of_documents_by_reference_."> </A>
<A NAME="toc_ja4574_5"> </A>
<BR></FONT><FONT SIZE=2><B>Item 3.&nbsp;&nbsp;</B></FONT><FONT SIZE=2><I>Incorporation of Documents by Reference</I></FONT><FONT SIZE=2>.    <BR></FONT></P>

<P><FONT SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;The
following documents, previously filed with the Securities and Exchange Commission by Transgenomic,&nbsp;Inc. (the "Registrant") pursuant to Securities Exchange Act of 1934, as
amended (the "Exchange Act"), are incorporated herein by reference: </FONT></P>

<UL>
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<DT><FONT SIZE=2>(a)</FONT></DT><DD><FONT SIZE=2>The
Registrant's Annual Report on Form&nbsp;10-K for the fiscal year ended December&nbsp;31, 2000 (File No.&nbsp;000-30975) filed on March&nbsp;16,
2001.
<BR><BR></FONT></DD><DT><FONT SIZE=2>(b)</FONT></DT><DD><FONT SIZE=2>All
reports filed under Section&nbsp;13(a) or 15(d) of the Securities Exchange Act of 1934 since December&nbsp;31, 2000.
<BR><BR></FONT></DD><DT><FONT SIZE=2>(c)</FONT></DT><DD><FONT SIZE=2>Description
of the Registrant's common stock incorporated into its Registration Statement on Form&nbsp;8-A filed with the SEC on July&nbsp;11, 2000 (File
No.&nbsp;000-30975). </FONT></DD></DL>
</UL>

<P><FONT SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;Each
document filed by the Registrant pursuant to Sections 13(a), 13(c), 14 and 15(d) of the Exchange Act subsequent to the date of this Registration Statement and prior to the filing
of a post-effective amendment that indicates that all securities offered herein have been sold or that deregisters all such securities then remaining unsold shall be deemed to be
incorporated by reference in this Registration Statement and to be a part hereof from the respective date of filing such documents. </FONT></P>

<P><FONT SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;Any
statement contained in a document incorporated by reference herein shall be deemed to be modified or superseded for purposes of this Registration Statement to the extent that a
statement contained herein or in any subsequently filed document that also is or is deemed to be incorporated by reference herein modifies or supersedes such statement. Any such statement so modified
or superseded shall not be deemed, except as so modified or superseded, to constitute a part of this Registration Statement. </FONT></P>

<P><FONT SIZE=2><A
NAME="ja4574_item_4_._description_of_securities."> </A>
<A NAME="toc_ja4574_6"> </A>
<BR></FONT><FONT SIZE=2><B>Item 4</B></FONT><FONT SIZE=2>.&nbsp;&nbsp;</FONT><FONT SIZE=2><I>Description of Securities.    <BR>  </I></FONT></P>

<P><FONT SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;Not Applicable. </FONT></P>


<P><FONT SIZE=2><A
NAME="ja4574_item_5._interests_of_named_experts_and_counsel."> </A>
<A NAME="toc_ja4574_7"> </A>
<BR></FONT><FONT SIZE=2><B>Item 5.&nbsp;&nbsp;</B></FONT><FONT SIZE=2><I>Interests of Named Experts and Counsel.    <BR>  </I></FONT></P>

<P><FONT SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;None. </FONT></P>

<P ALIGN="CENTER"><FONT SIZE=2>2</FONT></P>

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<P><FONT SIZE=2><A
NAME="ja4574_item_6._indemnification_of_directors_and_officers."> </A>
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<BR></FONT><FONT SIZE=2><B>Item 6.&nbsp;&nbsp;</B></FONT><FONT SIZE=2><I>Indemnification of Directors and Officers.    <BR>  </I></FONT></P>


<P><FONT SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;Section&nbsp;145 of the Delaware General Corporation Law authorizes a court to award, or a corporation to grant, indemnity to directors and officers in terms
sufficiently broad to permit such indemnification under certain circumstances for liabilities (including reimbursement of expenses incurred) arising under the Securities Act of 1933. </FONT></P>

<P><FONT SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;As
permitted by the Delaware General Corporation Law, our Restated Certificate of Incorporation eliminates the personal liability of its directors for monetary damages for breach of
fiduciary duty as a director, except for liability (1)&nbsp;for any breach of the director's duty of loyalty to us or its stockholders, (2)&nbsp;for acts or omissions not in good faith or that
involve intentional misconduct or a knowing violation of law, (3)&nbsp;under Section&nbsp;174 of the Delaware General Corporation Law (regarding unlawful dividends and stock purchases) or
(4)&nbsp;for any transaction from which the director derived an improper personal benefit. If the Delaware General Corporation Law is amended to authorize further elimination or limiting of
directors' personal liability, then the Restated Certificate provides that the personal liability of directors will be eliminated or limited to the fullest extent provided under the Delaware General
Corporation Law. </FONT></P>

<P><FONT SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;As
permitted by the Delaware General Corporation Law, our Amended and Restated Certificate of Incorporation and our Bylaws provide that (1)&nbsp;we are required to indemnify our
directors and officers to the fullest extent permitted by the Delaware General Corporation Law, subject to certain very limited exceptions, (2)&nbsp;we may indemnify our other employees and agents
as set forth in the Delaware General Corporation Law, (3)&nbsp;we are required to advance expenses, as incurred, to its directors and executive officers in connection with a legal proceeding to the
fullest extent permitted by the Delaware General Corporation Law, subject to certain conditions and (4)&nbsp;the rights conferred by the Restated Certificate of Incorporation and Bylaws are not
exclusive. </FONT></P>

<P><FONT SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;The
Delaware General Corporation Law authorizes a corporation to indemnify its directors and officers provided that the corporation shall not eliminate or limit the liability of a
director as follows: </FONT></P>

<UL>
<DL compact>
<DT><FONT SIZE=2>(a)</FONT></DT><DD><FONT SIZE=2>for
any action brought by or in the right of a corporation where the director or officer is adjudged to be liable to the corporation, except where a court determines the director or
officer is entitled to indemnity;
<BR><BR></FONT></DD><DT><FONT SIZE=2>(b)</FONT></DT><DD><FONT SIZE=2>for
acts or omissions not in good faith or which involve conduct that the director or officer believes is not in the best interests of the corporation;
<BR><BR></FONT></DD><DT><FONT SIZE=2>(c)</FONT></DT><DD><FONT SIZE=2>for
knowing violations of the law;
<BR><BR></FONT></DD><DT><FONT SIZE=2>(d)</FONT></DT><DD><FONT SIZE=2>for
any transaction from which the directors derived an improper personal benefit; and
<BR><BR></FONT></DD><DT><FONT SIZE=2>(e)</FONT></DT><DD><FONT SIZE=2>for
payment of dividends or approval of stock repurchases or redemptions leading to liability under Section&nbsp;174 of the Delaware General Corporation Law. </FONT></DD></DL>
</UL>

<P><FONT SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;The
Delaware General Corporation Law requires a corporation to indemnify a director or officer to the extent that the director or officer has been successful, on the merits or
otherwise, in defense of any action, suit or proceeding for which indemnification is lawful. </FONT></P>

<P><FONT SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;We
maintain a director and officer insurance policy which insures our directors and officers against damages, judgments, settlements and costs incurred by reason of certain wrongful
acts committed by such persons in their capacities as directors and officers. </FONT></P>

<P><FONT SIZE=2><A
NAME="ja4574_item_7._exemption_from_registration_claimed."> </A>
<A NAME="toc_ja4574_9"> </A>
<BR></FONT><FONT SIZE=2><B>Item 7.&nbsp;&nbsp;</B></FONT><FONT SIZE=2><I>Exemption from Registration Claimed.    <BR>  </I></FONT></P>

<P><FONT SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;Not Applicable </FONT></P>

<P ALIGN="CENTER"><FONT SIZE=2>3</FONT></P>

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NAME="ja4574_item_8._exhibits."> </A>
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<BR></FONT><FONT SIZE=2><B>Item 8.&nbsp;&nbsp;</B></FONT><FONT SIZE=2><I>Exhibits.    <BR>  </I></FONT></P>

<P><FONT SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;The following is a complete list of exhibits filed as part of this Registration Statement. Exhibit numbers correspond to the numbers in the Exhibit Table of
Item 601 of Regulation&nbsp;S-K. </FONT></P>

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<TH WIDTH="10%" ALIGN="CENTER"><FONT SIZE=1><B>Exhibit<BR>
Number</B></FONT><HR NOSHADE></TH>
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<TH WIDTH="88%" ALIGN="CENTER"><FONT SIZE=1><B>Description</B></FONT><HR NOSHADE></TH>
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<TD WIDTH="10%" ALIGN="RIGHT"><FONT SIZE=2>4(a)</FONT></TD>
<TD WIDTH="3%"><FONT SIZE=2>&nbsp;</FONT></TD>
<TD WIDTH="88%"><FONT SIZE=2>Specimen of Certificate of the Registrant's Common Stock, par value $0.01 per share (incorporated by reference to Exhibit 4 of the Registrant's Registration Statement on Form S-1 (Commission file No. 333-32174) dated
March&nbsp;10, 2000)</FONT></TD>
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<TD WIDTH="10%" ALIGN="RIGHT"><FONT SIZE=2>4(b)</FONT></TD>
<TD WIDTH="3%"><FONT SIZE=2>&nbsp;</FONT></TD>
<TD WIDTH="88%"><FONT SIZE=2>The Registrant's Second Amended and Restated 2001 Employee Stock Purchase Plan</FONT></TD>
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<TD WIDTH="10%" ALIGN="RIGHT"><FONT SIZE=2>5&nbsp;&nbsp;</FONT></TD>
<TD WIDTH="3%"><FONT SIZE=2>&nbsp;</FONT></TD>
<TD WIDTH="88%"><FONT SIZE=2>Opinion of Kutak Rock LLP</FONT></TD>
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<TD WIDTH="10%" ALIGN="RIGHT"><FONT SIZE=2>23(a)</FONT></TD>
<TD WIDTH="3%"><FONT SIZE=2>&nbsp;</FONT></TD>
<TD WIDTH="88%"><FONT SIZE=2>Consent of Kutak Rock LLP (included as part of Exhibit 5)</FONT></TD>
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<TD WIDTH="10%" ALIGN="RIGHT"><FONT SIZE=2>23(b)</FONT></TD>
<TD WIDTH="3%"><FONT SIZE=2>&nbsp;</FONT></TD>
<TD WIDTH="88%"><FONT SIZE=2>Consent of Deloitte &amp; Touche LLP</FONT></TD>
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<P><FONT SIZE=2><A
NAME="ja4574_item_9._undertakings"> </A>
<A NAME="toc_ja4574_11"> </A>
<BR></FONT><FONT SIZE=2><B>Item 9.&nbsp;&nbsp;</B></FONT><FONT SIZE=2><I>Undertakings</I></FONT></P>

<UL>

<P><FONT SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;The
undersigned Registrant hereby undertakes: </FONT></P>

<P><FONT SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;(a)(l)
To file, during any period in which offers or sales are being made, a post-effective amendment to this Registration Statement to include any material information
with respect to the plan of distribution not previously disclosed in the Registration Statement or any material change to such information in the Registration Statement; </FONT></P>


<P><FONT SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;(2)
That, for the purpose of determining any liability under the Securities Act, each such post-effective amendment shall be deemed to be a new Registration Statement
relating to the securities offered therein, and the offering of such securities at that time shall be deemed to be the initial </FONT><FONT SIZE=2><I>bona fide</I></FONT><FONT SIZE=2> offering
thereof; and </FONT></P>

<P><FONT SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;(3)
To remove from registration by means of a post-effective amendment any of the securities being registered which remain unsold at the termination of the offering. </FONT></P>

<P><FONT SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;(b)
That, for purposes of determining any liability under the Securities Act, each filing of the Registrant's annual report pursuant to Section&nbsp;13(a) or 15(d) of the Exchange
Act that is incorporated by reference in this Registration Statement shall be deemed to be a new Registration Statement
relating to the securities offered therein, and the offering of such securities at that time shall be deemed to be the initial </FONT><FONT SIZE=2><I>bona fide</I></FONT><FONT SIZE=2> offering
thereof. </FONT></P>

<P><FONT SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;(h)
That, insofar as indemnification for liabilities arising under the Securities Act may be permitted to directors, officers and controlling persons of the Registrant as described in
Item 6 hereof or otherwise, the Registrant has been advised that in the opinion of the Securities and Exchange Commission such indemnification is against public policy as expressed in the Securities
Act and is, therefore, unenforceable. In the event that a claim for indemnification against such liabilities (other than the payment by the Registrant of expenses incurred or paid by a director,
officer or controlling person of the Registrant in the successful defense of any action, suit or proceeding) is asserted by such director, officer or controlling person in connection with the
securities being registered, the Registrant will, unless in the opinion of its counsel the matter has been settled by controlling precedent, submit to a court of appropriate jurisdiction the question
whether such indemnification by it is against public policy as expressed in the Securities Act and will be governed by the final adjudication of such issue. </FONT></P>

</UL>
<P ALIGN="CENTER"><FONT SIZE=2>4</FONT></P>

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<A NAME="toc_jc4574_1"> </A>
<BR></FONT><FONT SIZE=2><B>SIGNATURES    <BR>  </B></FONT></P>

<P><FONT SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;Pursuant to the requirements of the Securities Act of 1933, as amended, the Registrant certifies that it has reasonable grounds to believe that it meets all of
the requirements for filing on Form&nbsp;S-8 and has duly caused this Registration Statement to be signed on its behalf by the undersigned, thereunto duly authorized, in the City of
Omaha, State of Nebraska, on&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;October&nbsp;19, 2001. </FONT></P>

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<TD WIDTH="3%"><FONT SIZE=2>&nbsp;</FONT></TD>
<TD COLSPAN=3><FONT SIZE=2>TRANSGENOMIC,&nbsp;INC.</FONT></TD>
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<TD WIDTH="47%"><FONT SIZE=2><BR>
&nbsp;</FONT></TD>
<TD WIDTH="3%"><FONT SIZE=2><BR>&nbsp;</FONT></TD>
<TD WIDTH="5%"><FONT SIZE=2><BR>
By:</FONT></TD>
<TD WIDTH="1%"><FONT SIZE=2><BR>&nbsp;</FONT></TD>
<TD WIDTH="45%" ALIGN="CENTER"><FONT SIZE=2><BR>
/s/&nbsp;</FONT><FONT SIZE=2>COLLIN J. D'SILVA</FONT><FONT SIZE=2>&nbsp;&nbsp;&nbsp;</FONT><HR NOSHADE><FONT SIZE=2> Collin J. D'Silva<BR></FONT> <FONT SIZE=2><I>Chairman and Chief Executive Officer</I></FONT></TD>
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<P><FONT SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;Pursuant
to the requirements of the Securities Act of 1933, as amended, this Registration Statement has been signed by the following persons in the capacities indicated as of
October&nbsp;19, 2001. </FONT></P>

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<TH WIDTH="3%"><FONT SIZE=1>&nbsp;</FONT></TH>
<TH WIDTH="50%" ALIGN="CENTER"><FONT SIZE=1><B>Title</B></FONT><HR NOSHADE></TH>
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<TR VALIGN="BOTTOM">
<TD WIDTH="47%" ALIGN="CENTER" VALIGN="CENTER"><BR><FONT SIZE=2>&nbsp;</FONT></TD>
<TD WIDTH="3%" VALIGN="CENTER"><FONT SIZE=2><BR>&nbsp;</FONT></TD>
<TD WIDTH="50%" VALIGN="TOP"><FONT SIZE=2><BR>
&nbsp;</FONT></TD>
</TR>
<TR VALIGN="TOP">
<TD WIDTH="47%" ALIGN="CENTER" VALIGN="CENTER"><FONT SIZE=2>/s/&nbsp;</FONT><FONT SIZE=2>COLLIN J. D'SILVA</FONT><FONT SIZE=2>&nbsp;&nbsp;&nbsp;</FONT><HR NOSHADE><FONT SIZE=2> Collin J. D'Silva</FONT></TD>
<TD WIDTH="3%" VALIGN="CENTER"><FONT SIZE=2>&nbsp;</FONT></TD>
<TD WIDTH="50%"><FONT SIZE=2>Chairman of the Board, Director, President and Chief Executive Officer (Principal Executive Officer)</FONT></TD>
</TR>
<TR VALIGN="TOP">
<TD WIDTH="47%" ALIGN="CENTER" VALIGN="CENTER"><FONT SIZE=2><BR>
/s/&nbsp;</FONT><FONT SIZE=2>GREGORY J. DUMAN</FONT><FONT SIZE=2>&nbsp;&nbsp;&nbsp;</FONT><HR NOSHADE><FONT SIZE=2> Gregory J. Duman</FONT></TD>
<TD WIDTH="3%" VALIGN="CENTER"><FONT SIZE=2><BR>&nbsp;</FONT></TD>
<TD WIDTH="50%"><FONT SIZE=2><BR>
Chief Financial Officer, Director<BR>
(Principal Financial Officer)</FONT></TD>
</TR>
<TR VALIGN="BOTTOM">
<TD WIDTH="47%" ALIGN="CENTER" VALIGN="CENTER"><FONT SIZE=2><BR>
/s/&nbsp;</FONT><FONT SIZE=2>STEPHEN F. DWYER</FONT><FONT SIZE=2>&nbsp;&nbsp;&nbsp;</FONT><HR NOSHADE><FONT SIZE=2> Stephen F. Dwyer</FONT></TD>
<TD WIDTH="3%" VALIGN="CENTER"><FONT SIZE=2><BR>&nbsp;</FONT></TD>
<TD WIDTH="50%" VALIGN="TOP"><FONT SIZE=2><BR>
Director</FONT></TD>
</TR>
<TR VALIGN="BOTTOM">
<TD WIDTH="47%" ALIGN="CENTER" VALIGN="CENTER"><FONT SIZE=2><BR>
/s/&nbsp;</FONT><FONT SIZE=2>JEFFREY SKLAR</FONT><FONT SIZE=2>&nbsp;&nbsp;&nbsp;</FONT><HR NOSHADE><FONT SIZE=2> Jeffrey Sklar, M.D., Ph.D.</FONT></TD>
<TD WIDTH="3%" VALIGN="CENTER"><FONT SIZE=2><BR>&nbsp;</FONT></TD>
<TD WIDTH="50%" VALIGN="TOP"><FONT SIZE=2><BR>
Director</FONT></TD>
</TR>
<TR VALIGN="BOTTOM">
<TD WIDTH="47%" ALIGN="CENTER" VALIGN="CENTER"><FONT SIZE=2><BR>
/s/&nbsp;</FONT><FONT SIZE=2>ROLAND J. SANTONI</FONT><FONT SIZE=2>&nbsp;&nbsp;&nbsp;</FONT><HR NOSHADE><FONT SIZE=2> Roland J. Santoni</FONT></TD>
<TD WIDTH="3%" VALIGN="CENTER"><FONT SIZE=2><BR>&nbsp;</FONT></TD>
<TD WIDTH="50%" VALIGN="TOP"><FONT SIZE=2><BR>
Director</FONT></TD>
</TR>
<TR VALIGN="BOTTOM">
<TD WIDTH="47%" ALIGN="CENTER" VALIGN="CENTER"><BR><HR NOSHADE><FONT SIZE=2> Parag Saxena</FONT></TD>
<TD WIDTH="3%" VALIGN="CENTER"><FONT SIZE=2><BR>&nbsp;</FONT></TD>
<TD WIDTH="50%" VALIGN="TOP"><FONT SIZE=2><BR>
Director</FONT></TD>
</TR>
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<P ALIGN="CENTER"><FONT SIZE=2>5</FONT></P>

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<P ALIGN="CENTER"><FONT SIZE=2><A
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<A NAME="toc_ka4574_1"> </A>
<BR></FONT><FONT SIZE=2><B>EXHIBIT INDEX    <BR>  </B></FONT></P>

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<TH WIDTH="10%" ALIGN="CENTER"><FONT SIZE=1><B>Exhibit<BR>
Number</B></FONT><HR NOSHADE></TH>
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<TH WIDTH="88%" ALIGN="CENTER"><FONT SIZE=1><B>Description</B></FONT><HR NOSHADE></TH>
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<TD WIDTH="10%" ALIGN="RIGHT"><FONT SIZE=2>4(a)</FONT></TD>
<TD WIDTH="3%"><FONT SIZE=2>&nbsp;</FONT></TD>
<TD WIDTH="88%"><FONT SIZE=2>Specimen of Certificate of the Registrant's Common Stock, par value $0.01 per share (incorporated by reference to Exhibit 4 of the Registrant's Registration Statement on Form S-1 (Commission file No. 333-32174) dated
March 10, 2000)</FONT></TD>
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<TD WIDTH="10%" ALIGN="RIGHT"><FONT SIZE=2><BR>
4(b)</FONT></TD>
<TD WIDTH="3%"><FONT SIZE=2><BR>&nbsp;</FONT></TD>
<TD WIDTH="88%"><FONT SIZE=2><BR>
The Registrant's Second Amended and Restated 2001 Employee Stock Purchase Plan</FONT></TD>
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<TD WIDTH="10%" ALIGN="RIGHT"><FONT SIZE=2><BR>
&nbsp;5&nbsp;&nbsp;</FONT></TD>
<TD WIDTH="3%"><FONT SIZE=2><BR>&nbsp;</FONT></TD>
<TD WIDTH="88%"><FONT SIZE=2><BR>
Opinion of Kutak Rock LLP</FONT></TD>
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<TD WIDTH="10%" ALIGN="RIGHT"><FONT SIZE=2><BR>
23(a)</FONT></TD>
<TD WIDTH="3%"><FONT SIZE=2><BR>&nbsp;</FONT></TD>
<TD WIDTH="88%"><FONT SIZE=2><BR>
Consent of Kutak Rock LLP (included as part of Exhibit 5)</FONT></TD>
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<TD WIDTH="10%" ALIGN="RIGHT"><FONT SIZE=2><BR>
23(b)</FONT></TD>
<TD WIDTH="3%"><FONT SIZE=2><BR>&nbsp;</FONT></TD>
<TD WIDTH="88%"><FONT SIZE=2><BR>
Consent of Deloitte &amp; Touche LLP</FONT></TD>
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<P ALIGN="CENTER"><FONT SIZE=2>6</FONT></P>

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<P><br><A NAME="01CHI4574_1">QuickLinks</A><br></P><!-- TOC_BEGIN -->
<FONT SIZE=2><A HREF="#toc_ja4574_1">PART I INFORMATION REQUIRED IN THE Section 10(a) PROSPECTUS</A></FONT><BR>
<UL>
<FONT SIZE=2><A HREF="#toc_ja4574_2">Item 1. Plan Information</A></FONT><BR>
<FONT SIZE=2><A HREF="#toc_ja4574_3">Item 2. Registration Information and Employee Plan Annual Information.</A></FONT><BR>
</UL>
<FONT SIZE=2><A HREF="#toc_ja4574_4">PART II INFORMATION REQUIRED IN THE REGISTRATION STATEMENT</A></FONT><BR>
<UL>
<FONT SIZE=2><A HREF="#toc_ja4574_5">Item 3. Incorporation of Documents by Reference .</A></FONT><BR>
<FONT SIZE=2><A HREF="#toc_ja4574_6">Item 4 . Description of Securities.</A></FONT><BR>
<FONT SIZE=2><A HREF="#toc_ja4574_7">Item 5. Interests of Named Experts and Counsel.</A></FONT><BR>
<FONT SIZE=2><A HREF="#toc_ja4574_8">Item 6. Indemnification of Directors and Officers.</A></FONT><BR>
<FONT SIZE=2><A HREF="#toc_ja4574_9">Item 7. Exemption from Registration Claimed.</A></FONT><BR>
<FONT SIZE=2><A HREF="#toc_ja4574_10">Item 8. Exhibits.</A></FONT><BR>
<FONT SIZE=2><A HREF="#toc_ja4574_11">Item 9. Undertakings</A></FONT><BR>
</UL>
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<FONT SIZE=2><A HREF="#toc_jc4574_1">SIGNATURES</A></FONT><BR>
<!-- TOC_BEGIN -->
<FONT SIZE=2><A HREF="#toc_ka4574_1">EXHIBIT INDEX</A></FONT><BR>
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[{"type": "S-8", "sequence": "1", "filename": "a2061453zs-8.htm", "description": "FORM S-8", "secsgml_size_bytes": 30277}]
{"company-data": {"conformed-name": "TRANSGENOMIC INC", "cik": "0001043961", "assigned-sic": "3826", "irs-number": "911789357", "state-of-incorporation": "DE", "fiscal-year-end": "1231"}, "filing-values": {"form-type": "S-8", "act": "33", "file-number": "333-71866", "film-number": "1762197"}, "business-address": {"street1": "12325 EMMET ST", "city": "OMAHA", "state": "NE", "zip": "68164", "phone": "4027385480"}, "mail-address": {"street1": "12325 EMMET STREET", "city": "OMAHA", "state": "NE", "zip": "68164"}}
Prepared by MERRILL CORPORATION
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As filed with the Securities and Exchange Commission on October 19, 2001
SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM S-8
Registration Statement
Under the Securities Act of 1933
TRANSGENOMIC, INC.
(Exact name of registrant as specified in its charter)
Delaware
91-1789357
(State or other jurisdiction of
incorporation or organization)
(I.R.S. Employer
Identification No.)
12325 Emmet Street, Omaha, NE
68164
(Address of principal executive offices)
(Zip code)
TRANSGENOMIC, INC.
SECOND AMENDED AND RESTATED 2001 EMPLOYEE STOCK PURCHASE PLAN
(Full title of the plan)
Collin J. D'Silva
Chairman and Chief Executive Officer
Transgenomic, Inc.
12325 Emmet Street,
Omaha, NE 68164
(402) 452-5400
(Name and address of agent for service)
(Telephone number, including area
code, of agent for service)
Copies to:
Steven P. Amen, Esq.
Kutak Rock LLP
1650 Farnam Street
Omaha, Nebraska 68102
(402) 346-6000
CALCULATION OF REGISTRATION FEE
Title of Securities to be Registered
Amount to Be Registered(1)
Proposed Maximum Offering Price Per Share(2)
Proposed Maximum Aggregate Offering Price
Amount of Registration Fee
Common Stock, par value $0.01 per share
500,000 shares
$8.35
$4,175,000
$1,043.75
(1)
This
Registration Statement shall also cover any additional shares of Registrant's common stock which become issuable under the Second Amended and Restated 2001 Employee Stock
Purchase Plan, as amended from time to time, with respect to the securities registered hereunder by reason of any stock dividend, stock split, recapitalization or other similar transaction effected
without the Registrant's receipt of consideration which results in an increase in the number of the Registrant's outstanding shares of common stock.
(2)
Estimated
pursuant to Rule 457(c) and (h) solely for purposes of calculating the registration fee. The price per share is estimated to be $8.35 based on the average of
the high ($9.00) and low ($7.69) sale prices for the Common Stock as reported by the Nasdaq National Market on October 12, 2001.
PART I
INFORMATION REQUIRED IN THE
Section 10(a) PROSPECTUS
Item 1.
Plan Information
Information
required by Part I of Form S-8 to be contained in the Section 10(a) prospectus is omitted from this registration statement in accordance
with Rule 428 under the Securities Act of 1933, as amended ("Securities Act") and the Note to Part I of Form S-8.
Item 2.
Registration Information and Employee Plan Annual Information.
Information
required by Part I of Form S-8 to be contained in the Section 10(a) prospectus is omitted from this registration statement in accordance
with Rule 428 under the Securities Act and the Note to Part I of Form S-8.
PART II
INFORMATION REQUIRED IN THE REGISTRATION STATEMENT
Item 3.
Incorporation of Documents by Reference
.
The
following documents, previously filed with the Securities and Exchange Commission by Transgenomic, Inc. (the "Registrant") pursuant to Securities Exchange Act of 1934, as
amended (the "Exchange Act"), are incorporated herein by reference:
(a)
The
Registrant's Annual Report on Form 10-K for the fiscal year ended December 31, 2000 (File No. 000-30975) filed on March 16,
2001.
(b)
All
reports filed under Section 13(a) or 15(d) of the Securities Exchange Act of 1934 since December 31, 2000.
(c)
Description
of the Registrant's common stock incorporated into its Registration Statement on Form 8-A filed with the SEC on July 11, 2000 (File
No. 000-30975).
Each
document filed by the Registrant pursuant to Sections 13(a), 13(c), 14 and 15(d) of the Exchange Act subsequent to the date of this Registration Statement and prior to the filing
of a post-effective amendment that indicates that all securities offered herein have been sold or that deregisters all such securities then remaining unsold shall be deemed to be
incorporated by reference in this Registration Statement and to be a part hereof from the respective date of filing such documents.
Any
statement contained in a document incorporated by reference herein shall be deemed to be modified or superseded for purposes of this Registration Statement to the extent that a
statement contained herein or in any subsequently filed document that also is or is deemed to be incorporated by reference herein modifies or supersedes such statement. Any such statement so modified
or superseded shall not be deemed, except as so modified or superseded, to constitute a part of this Registration Statement.
Item 4
.
Description of Securities.
Not Applicable.
Item 5.
Interests of Named Experts and Counsel.
None.
2
Item 6.
Indemnification of Directors and Officers.
Section 145 of the Delaware General Corporation Law authorizes a court to award, or a corporation to grant, indemnity to directors and officers in terms
sufficiently broad to permit such indemnification under certain circumstances for liabilities (including reimbursement of expenses incurred) arising under the Securities Act of 1933.
As
permitted by the Delaware General Corporation Law, our Restated Certificate of Incorporation eliminates the personal liability of its directors for monetary damages for breach of
fiduciary duty as a director, except for liability (1) for any breach of the director's duty of loyalty to us or its stockholders, (2) for acts or omissions not in good faith or that
involve intentional misconduct or a knowing violation of law, (3) under Section 174 of the Delaware General Corporation Law (regarding unlawful dividends and stock purchases) or
(4) for any transaction from which the director derived an improper personal benefit. If the Delaware General Corporation Law is amended to authorize further elimination or limiting of
directors' personal liability, then the Restated Certificate provides that the personal liability of directors will be eliminated or limited to the fullest extent provided under the Delaware General
Corporation Law.
As
permitted by the Delaware General Corporation Law, our Amended and Restated Certificate of Incorporation and our Bylaws provide that (1) we are required to indemnify our
directors and officers to the fullest extent permitted by the Delaware General Corporation Law, subject to certain very limited exceptions, (2) we may indemnify our other employees and agents
as set forth in the Delaware General Corporation Law, (3) we are required to advance expenses, as incurred, to its directors and executive officers in connection with a legal proceeding to the
fullest extent permitted by the Delaware General Corporation Law, subject to certain conditions and (4) the rights conferred by the Restated Certificate of Incorporation and Bylaws are not
exclusive.
The
Delaware General Corporation Law authorizes a corporation to indemnify its directors and officers provided that the corporation shall not eliminate or limit the liability of a
director as follows:
(a)
for
any action brought by or in the right of a corporation where the director or officer is adjudged to be liable to the corporation, except where a court determines the director or
officer is entitled to indemnity;
(b)
for
acts or omissions not in good faith or which involve conduct that the director or officer believes is not in the best interests of the corporation;
(c)
for
knowing violations of the law;
(d)
for
any transaction from which the directors derived an improper personal benefit; and
(e)
for
payment of dividends or approval of stock repurchases or redemptions leading to liability under Section 174 of the Delaware General Corporation Law.
The
Delaware General Corporation Law requires a corporation to indemnify a director or officer to the extent that the director or officer has been successful, on the merits or
otherwise, in defense of any action, suit or proceeding for which indemnification is lawful.
We
maintain a director and officer insurance policy which insures our directors and officers against damages, judgments, settlements and costs incurred by reason of certain wrongful
acts committed by such persons in their capacities as directors and officers.
Item 7.
Exemption from Registration Claimed.
Not Applicable
3
Item 8.
Exhibits.
The following is a complete list of exhibits filed as part of this Registration Statement. Exhibit numbers correspond to the numbers in the Exhibit Table of
Item 601 of Regulation S-K.
Exhibit
Number
Description
4(a)
Specimen of Certificate of the Registrant's Common Stock, par value $0.01 per share (incorporated by reference to Exhibit 4 of the Registrant's Registration Statement on Form S-1 (Commission file No. 333-32174) dated
March 10, 2000)
4(b)
The Registrant's Second Amended and Restated 2001 Employee Stock Purchase Plan
5
Opinion of Kutak Rock LLP
23(a)
Consent of Kutak Rock LLP (included as part of Exhibit 5)
23(b)
Consent of Deloitte & Touche LLP
Item 9.
Undertakings
The
undersigned Registrant hereby undertakes:
(a)(l)
To file, during any period in which offers or sales are being made, a post-effective amendment to this Registration Statement to include any material information
with respect to the plan of distribution not previously disclosed in the Registration Statement or any material change to such information in the Registration Statement;
(2)
That, for the purpose of determining any liability under the Securities Act, each such post-effective amendment shall be deemed to be a new Registration Statement
relating to the securities offered therein, and the offering of such securities at that time shall be deemed to be the initial
bona fide
offering
thereof; and
(3)
To remove from registration by means of a post-effective amendment any of the securities being registered which remain unsold at the termination of the offering.
(b)
That, for purposes of determining any liability under the Securities Act, each filing of the Registrant's annual report pursuant to Section 13(a) or 15(d) of the Exchange
Act that is incorporated by reference in this Registration Statement shall be deemed to be a new Registration Statement
relating to the securities offered therein, and the offering of such securities at that time shall be deemed to be the initial
bona fide
offering
thereof.
(h)
That, insofar as indemnification for liabilities arising under the Securities Act may be permitted to directors, officers and controlling persons of the Registrant as described in
Item 6 hereof or otherwise, the Registrant has been advised that in the opinion of the Securities and Exchange Commission such indemnification is against public policy as expressed in the Securities
Act and is, therefore, unenforceable. In the event that a claim for indemnification against such liabilities (other than the payment by the Registrant of expenses incurred or paid by a director,
officer or controlling person of the Registrant in the successful defense of any action, suit or proceeding) is asserted by such director, officer or controlling person in connection with the
securities being registered, the Registrant will, unless in the opinion of its counsel the matter has been settled by controlling precedent, submit to a court of appropriate jurisdiction the question
whether such indemnification by it is against public policy as expressed in the Securities Act and will be governed by the final adjudication of such issue.
4
SIGNATURES
Pursuant to the requirements of the Securities Act of 1933, as amended, the Registrant certifies that it has reasonable grounds to believe that it meets all of
the requirements for filing on Form S-8 and has duly caused this Registration Statement to be signed on its behalf by the undersigned, thereunto duly authorized, in the City of
Omaha, State of Nebraska, on      October 19, 2001.
TRANSGENOMIC, INC.
By:
/s/
COLLIN J. D'SILVA
Collin J. D'Silva
Chairman and Chief Executive Officer
Pursuant
to the requirements of the Securities Act of 1933, as amended, this Registration Statement has been signed by the following persons in the capacities indicated as of
October 19, 2001.
Signature
Title
/s/
COLLIN J. D'SILVA
Collin J. D'Silva
Chairman of the Board, Director, President and Chief Executive Officer (Principal Executive Officer)
/s/
GREGORY J. DUMAN
Gregory J. Duman
Chief Financial Officer, Director
(Principal Financial Officer)
/s/
STEPHEN F. DWYER
Stephen F. Dwyer
Director
/s/
JEFFREY SKLAR
Jeffrey Sklar, M.D., Ph.D.
Director
/s/
ROLAND J. SANTONI
Roland J. Santoni
Director
Parag Saxena
Director
5
EXHIBIT INDEX
Exhibit
Number
Description
4(a)
Specimen of Certificate of the Registrant's Common Stock, par value $0.01 per share (incorporated by reference to Exhibit 4 of the Registrant's Registration Statement on Form S-1 (Commission file No. 333-32174) dated
March 10, 2000)
4(b)
The Registrant's Second Amended and Restated 2001 Employee Stock Purchase Plan
5
Opinion of Kutak Rock LLP
23(a)
Consent of Kutak Rock LLP (included as part of Exhibit 5)
23(b)
Consent of Deloitte & Touche LLP
6
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PART I INFORMATION REQUIRED IN THE Section 10(a) PROSPECTUS
Item 1. Plan Information
Item 2. Registration Information and Employee Plan Annual Information.
PART II INFORMATION REQUIRED IN THE REGISTRATION STATEMENT
Item 3. Incorporation of Documents by Reference .
Item 4 . Description of Securities.
Item 5. Interests of Named Experts and Counsel.
Item 6. Indemnification of Directors and Officers.
Item 7. Exemption from Registration Claimed.
Item 8. Exhibits.
Item 9. Undertakings
SIGNATURES
EXHIBIT INDEX