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<TITLE>MBI/FFB Amendment No. 2 on Form S-8 to Form S-4</TITLE>
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<P ALIGN="RIGHT"><FONT SIZE=2>&#9;<B>As Filed With the Securities and Exchange Commission on December 20, 2002 </P>
</B><P ALIGN="RIGHT">&#9;<B>Registration No.</B> <B>333-_______</P>
<P ALIGN="CENTER"><FONT SIZE=2>UNITED STATES</P>
<P ALIGN="CENTER">SECURITIES AND EXCHANGE COMMISSION</P>
</B><P ALIGN="CENTER"><FONT SIZE=2>Washington, D.&nbsp;C. 20549</P>
<B><P ALIGN="CENTER">_______________________</P>
<P ALIGN="CENTER">&nbsp;</P>
<P ALIGN="CENTER">FORM S-8</P>
<P ALIGN="CENTER">Registration Statement Under</P>
<P ALIGN="CENTER">The Securities Act of 1933</P>
<P ALIGN="CENTER">________________________</P>
<P ALIGN="CENTER">TRIPOS, INC.</B></P>
</B><P ALIGN="CENTER"></B><FONT SIZE=2>(Exact name of registrant as specified in its charter)</P>
<P ALIGN="RIGHT"><TABLE CELLSPACING=0 BORDER=0 CELLPADDING=7 WIDTH=528>
<TR><TD WIDTH="47%" VALIGN="TOP">
<B><P ALIGN="CENTER"><FONT SIZE=2>Utah</B></TD>
<TD WIDTH="6%" VALIGN="TOP">&nbsp;</TD>
<TD WIDTH="48%" VALIGN="TOP">
<B><P ALIGN="CENTER"><FONT SIZE=2>43-1454986</B></TD>
</TR>
<TR><TD WIDTH="47%" VALIGN="TOP">
<P ALIGN="CENTER"><FONT SIZE=2>(State or other jurisdiction of</TD>
<TD WIDTH="6%" VALIGN="TOP">&nbsp;</TD>
<TD WIDTH="48%" VALIGN="TOP">
<P ALIGN="CENTER"><FONT SIZE=2>(I.R.S. Employer</TD>
</TR>
<TR><TD WIDTH="47%" VALIGN="TOP">
<P ALIGN="CENTER"><FONT SIZE=2>incorporation or organization)</TD>
<TD WIDTH="6%" VALIGN="TOP">&nbsp;</TD>
<TD WIDTH="48%" VALIGN="TOP">
<P ALIGN="CENTER"><FONT SIZE=2>Identification No.)</TD>
</TR>
</TABLE>
</P>

<P ALIGN="CENTER">&nbsp;</P>
<B><P ALIGN="CENTER">1699 South Hanley Road</B>&#9;</P>
<B><P ALIGN="CENTER">St. Louis, Missouri 63144</P>
</B><P ALIGN="CENTER">(Address of Principal Executive Offices)</P>
<P ALIGN="CENTER">_________________________</P>
<B><P ALIGN="CENTER">TRIPOS, INC. 1994 DIRECTOR STOCK OPTION PLAN</P>
</B><P ALIGN="CENTER">(Full title of the plans)</P>
<U><P ALIGN="CENTER">&nbsp;</P>
</U><B><P ALIGN="CENTER">Dr.</B> <B>John P. McAlister</P>
<P ALIGN="CENTER">President and Chief Executive Officer</P>
<P ALIGN="CENTER">Tripos, Inc.</P>
<P ALIGN="CENTER">1699 South Hanley Road</P>
<P ALIGN="CENTER">St. Louis, Missouri 63144</P>
</B><P ALIGN="CENTER">(Name and address of agent for service)</P>
<P ALIGN="CENTER">Telephone number, including area code, of agent for service: <B>(314) 647-1099</P>
</B><P ALIGN="CENTER">________________________</P>
<U><P ALIGN="CENTER">&nbsp;</P>
</U><P ALIGN="CENTER">Copies to:</P>
<P ALIGN="CENTER">Roger D. Stern, Esq.</P>
<P ALIGN="CENTER">Wilson Sonsini Goodrich &amp; Rosati, PC<BR>
950 Page Mill Road<BR>
Palo Alto, California 94304</P>
<P ALIGN="JUSTIFY">&#9;CALCULATION OF REGISTRATION FEE</P>
<P ALIGN="CENTER"><CENTER><TABLE BORDER=0 CELLSPACING=1 CELLPADDING=8 WIDTH=741>
<TR><TD WIDTH="28%" VALIGN="TOP">
<P ALIGN="CENTER"><FONT SIZE=2>Title of each class of </P>
<P ALIGN="CENTER"><FONT SIZE=2>securities to be registered </TD>
<TD WIDTH="15%" VALIGN="TOP">
<P ALIGN="CENTER"><FONT SIZE=2>Amount to be registered <SUP>(2)</SUP></TD>
<TD WIDTH="22%" VALIGN="TOP">
<P ALIGN="CENTER"><FONT SIZE=2>Proposed maximum offering price per unit <SUP>(3)</SUP></TD>
<TD WIDTH="21%" VALIGN="TOP">
<P ALIGN="CENTER"><FONT SIZE=2>Proposed maximum aggregate offering price <SUP>(3)</SUP> </TD>
<TD WIDTH="14%" VALIGN="TOP">
<P ALIGN="CENTER"><FONT SIZE=2>Amount of registration fee</TD>
</TR>
<TR><TD WIDTH="28%" VALIGN="TOP">
<P ALIGN="CENTER"><FONT SIZE=2>Common Stock, $.005 par value<SUP>(1)</SUP> </TD>
<TD WIDTH="15%" VALIGN="TOP">
<P ALIGN="CENTER"><FONT SIZE=2>&nbsp;120,000</TD>
<TD WIDTH="22%" VALIGN="TOP">
<P ALIGN="CENTER"><FONT SIZE=2>&nbsp;$7.26</TD>
<TD WIDTH="21%" VALIGN="TOP">
<P ALIGN="CENTER"><FONT SIZE=2>&nbsp;$871,200 </TD>
<TD WIDTH="14%" VALIGN="TOP">
<P ALIGN="CENTER"><FONT SIZE=2>&nbsp;$80.15</TD>
</TR>
</TABLE>
</CENTER></P>
<DIR>
<DIR>
<DIR>

<P ALIGN="JUSTIFY">&#9;(1)&#9;Includes one attached preferred stock purchase right per share.</P>
<P ALIGN="JUSTIFY">&#9;(2)&#9;The shares being registered hereby are reserved for issuance pursuant to the Tripos, Inc. 1994 Director Stock Option Plan. </P>
<P ALIGN="JUSTIFY">&#9;(3)&#9;Estimated solely for purposes of computing the Registration Fee pursuant to the provisions of Rule 457(h), based upon a price of $7.26 per share, being the average of the high and low transaction prices of the Registrant's common stock per share as reported on the Nasdaq National Market on December 19, 2002. </P>
<U><P ALIGN="JUSTIFY">&nbsp;</P></DIR>
</DIR>
</DIR>

</U><P ALIGN="JUSTIFY">&nbsp;</P>
<B><P ALIGN="CENTER">TRIPOS, INC.</P>
<P ALIGN="CENTER">1994 DIRECTOR STOCK OPTION PLAN</P>
</B><U><P ALIGN="LEFT">EXPLANATORY NOTE</P>
</U><P ALIGN="LEFT">&#9;This Registration Statement on Form S-8 is being filed by Tripos, Inc. in connection with the registration of an additional 120,000 shares of common stock, $.005 par value per share, to be issued pursuant to the Tripos, Inc. 1994 Director Stock Option Plan. The contents of the Registration Statement on Form S-8 (Reg. No. 333-61829) filed by Tripos, Inc. with the Securities and Exchange Commission on August 19, 1998, other than Item 5, are incorporated herein by reference. </P>
<P ALIGN="JUSTIFY">&nbsp;</P>
<P ALIGN="JUSTIFY">Item 5. &#9;Not Applicable.</P>
<P ALIGN="JUSTIFY">Item 8.&#9;<U>Exhibits</U>.</P>
<P ALIGN="JUSTIFY">See Exhibit Index located at page 5 hereof.</P>
<P ALIGN="JUSTIFY">&nbsp;</P>
<P ALIGN="JUSTIFY">&nbsp;</P>
<P ALIGN="JUSTIFY">&nbsp;</P>
<P ALIGN="JUSTIFY">&nbsp;</P>
<P ALIGN="JUSTIFY">&nbsp;</P>
<P ALIGN="JUSTIFY">&nbsp;</P>
<P ALIGN="JUSTIFY">&nbsp;</P>
<P ALIGN="JUSTIFY">&#9;<U>SIGNATURES</P>
</U><I><P ALIGN="JUSTIFY">&#9;&#9;</I>Pursuant to the requirements of the Securities Act of 1933, the Registrant certifies that it has reasonable grounds to believe that it meets all of the requirements for filing on Form S-8 and has duly caused this Amendment No. 1<FONT COLOR="#ff0000"> </FONT>to Registration Statement (File No. 333-______) to be signed on its behalf by the undersigned, thereunto duly authorized, in the County of St. Louis, State of Missouri, on the 20<SUP>th</SUP> day of December 2002.</P>
<P ALIGN="JUSTIFY">&#9;&#9;</P>
<TABLE CELLSPACING=0 BORDER=0 CELLPADDING=7 WIDTH=638>
<TR><TD WIDTH="45%" VALIGN="TOP">
<P>&nbsp;</TD>
<TD WIDTH="55%" VALIGN="TOP">
<P ALIGN="JUSTIFY"><FONT SIZE=2>TRIPOS, INC.</TD>
</TR>
<TR><TD WIDTH="45%" VALIGN="TOP">
<P>&nbsp;</TD>
<TD WIDTH="55%" VALIGN="TOP">
<P ALIGN="JUSTIFY">&nbsp;</TD>
</TR>
<TR><TD WIDTH="45%" VALIGN="TOP">
<P>&nbsp;</TD>
<TD WIDTH="55%" VALIGN="TOP">
<P ALIGN="JUSTIFY"><FONT SIZE=2>By: <U>/s/ John P. McAlister</U></TD>
</TR>
<TR><TD WIDTH="45%" VALIGN="TOP">
<P>&nbsp;</TD>
<TD WIDTH="55%" VALIGN="TOP">
<P ALIGN="JUSTIFY"><FONT SIZE=2>John P. McAlister</TD>
</TR>
<TR><TD WIDTH="45%" VALIGN="TOP">
<P>&nbsp;</TD>
<TD WIDTH="55%" VALIGN="TOP">
<P ALIGN="JUSTIFY"><FONT SIZE=2>President and Chief Executive Officer</TD>
</TR>
</TABLE>
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<P>&#9;&#9;&#9;</P>
<P>&#9;&#9;&#9;</P>
<P>&nbsp;</P></DIR>
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<P ALIGN="JUSTIFY">&#9;Pursuant to the requirements of the Securities Act of 1933, this Registration Statement has been signed by the following persons in the capacities and on the dates indicated.</P>
<TABLE CELLSPACING=0 BORDER=0 CELLPADDING=7 WIDTH=618>
<TR><TD WIDTH="33%" VALIGN="TOP">
<P ALIGN="CENTER"><FONT SIZE=2><B>Signature</B></TD>
<TD WIDTH="41%" VALIGN="TOP">
<B><P ALIGN="CENTER"><FONT SIZE=2>Title</B></TD>
<TD WIDTH="26%" VALIGN="TOP">
<B><P ALIGN="CENTER"><FONT SIZE=2>Date</B></TD>
</TR>
<TR><TD WIDTH="33%" VALIGN="TOP">
<P>&nbsp;</TD>
<TD WIDTH="41%" VALIGN="TOP">
<P>&nbsp;</TD>
<TD WIDTH="26%" VALIGN="TOP">
<P>&nbsp;</TD>
</TR>
<TR><TD WIDTH="33%" VALIGN="TOP">
<U><P><FONT SIZE=2>/s/ John P. McAlister</U></TD>
<TD WIDTH="41%" VALIGN="TOP">
<P><FONT SIZE=2>President, Chief Executive</TD>
<TD WIDTH="26%" VALIGN="TOP">
<P><FONT SIZE=2>December 20, 2002</TD>
</TR>
<TR><TD WIDTH="33%" VALIGN="TOP">
<P><FONT SIZE=2>John P. McAlister</TD>
<TD WIDTH="41%" VALIGN="TOP">
<P><FONT SIZE=2>Officer and Director</TD>
<TD WIDTH="26%" VALIGN="TOP">
<P>&nbsp;</TD>
</TR>
<TR><TD WIDTH="33%" VALIGN="TOP">
<P>&nbsp;</TD>
<TD WIDTH="41%" VALIGN="TOP">
<P><FONT SIZE=2>Principal Executive Officer</TD>
<TD WIDTH="26%" VALIGN="TOP">
<P>&nbsp;</TD>
</TR>
<TR><TD WIDTH="33%" VALIGN="TOP">
<P>&nbsp;</TD>
<TD WIDTH="41%" VALIGN="TOP">
<P>&nbsp;</TD>
<TD WIDTH="26%" VALIGN="TOP">
<P>&nbsp;</TD>
</TR>
<TR><TD WIDTH="33%" VALIGN="TOP">
<U><P><FONT SIZE=2>/s/ B. James Rubin</U></TD>
<TD WIDTH="41%" VALIGN="TOP">
<P><FONT SIZE=2>Senior Vice President, Chief</TD>
<TD WIDTH="26%" VALIGN="TOP">
<P><FONT SIZE=2>December 20, 2002</TD>
</TR>
<TR><TD WIDTH="33%" VALIGN="TOP">
<P><FONT SIZE=2>B. James Rubin&#9;</TD>
<TD WIDTH="41%" VALIGN="TOP">
<P><FONT SIZE=2>Financial Officer and Secretary</TD>
<TD WIDTH="26%" VALIGN="TOP">
<P>&nbsp;</TD>
</TR>
<TR><TD WIDTH="33%" VALIGN="TOP">
<P>&nbsp;</TD>
<TD WIDTH="41%" VALIGN="TOP">
<P><FONT SIZE=2>Principal Financial Officer</TD>
<TD WIDTH="26%" VALIGN="TOP">
<P>&nbsp;</TD>
</TR>
<TR><TD WIDTH="33%" VALIGN="TOP">
<P>&nbsp;</TD>
<TD WIDTH="41%" VALIGN="TOP">
<P>&nbsp;</TD>
<TD WIDTH="26%" VALIGN="TOP">
<P>&nbsp;</TD>
</TR>
<TR><TD WIDTH="33%" VALIGN="TOP">
<U><P><FONT SIZE=2>/s/ John D. Yingling</U></TD>
<TD WIDTH="41%" VALIGN="TOP">
<P><FONT SIZE=2>Vice President, Chief Accounting</TD>
<TD WIDTH="26%" VALIGN="TOP">
<P><FONT SIZE=2>December 20, 2002</TD>
</TR>
<TR><TD WIDTH="33%" VALIGN="TOP">
<P><FONT SIZE=2>John D. Yingling</TD>
<TD WIDTH="41%" VALIGN="TOP">
<P><FONT SIZE=2>Officer and Assistant Secretary</TD>
<TD WIDTH="26%" VALIGN="TOP">
<P>&nbsp;</TD>
</TR>
<TR><TD WIDTH="33%" VALIGN="TOP">
<P>&nbsp;</TD>
<TD WIDTH="41%" VALIGN="TOP">
<P><FONT SIZE=2>Principal Accounting Officer</TD>
<TD WIDTH="26%" VALIGN="TOP">
<P>&nbsp;</TD>
</TR>
<TR><TD WIDTH="33%" VALIGN="TOP">
<P>&nbsp;</TD>
<TD WIDTH="41%" VALIGN="TOP">
<P>&nbsp;</TD>
<TD WIDTH="26%" VALIGN="TOP">
<P>&nbsp;</TD>
</TR>
<TR><TD WIDTH="33%" VALIGN="TOP">
<U><P>&#9;* &#9;</U></TD>
<TD WIDTH="41%" VALIGN="TOP">
<P><FONT SIZE=2>Chairman of the Board</TD>
<TD WIDTH="26%" VALIGN="TOP">
<P><FONT SIZE=2>December 20, 2002</TD>
</TR>
<TR><TD WIDTH="33%" VALIGN="TOP">
<P><FONT SIZE=2>Ralph S. Lobdell</TD>
<TD WIDTH="41%" VALIGN="TOP">
<P><FONT SIZE=2>of Directors</TD>
<TD WIDTH="26%" VALIGN="TOP">
<P>&nbsp;</TD>
</TR>
<TR><TD WIDTH="33%" VALIGN="TOP">
<P>&nbsp;</TD>
<TD WIDTH="41%" VALIGN="TOP">
<P>&nbsp;</TD>
<TD WIDTH="26%" VALIGN="TOP">
<P>&nbsp;</TD>
</TR>
<TR><TD WIDTH="33%" VALIGN="TOP">
<U><P>&#9;*&#9;</U></TD>
<TD WIDTH="41%" VALIGN="TOP">
<P><FONT SIZE=2>Director</TD>
<TD WIDTH="26%" VALIGN="TOP">
<P><FONT SIZE=2>December 20, 2002</TD>
</TR>
<TR><TD WIDTH="33%" VALIGN="TOP">
<P><FONT SIZE=2>Gary Meredith</TD>
<TD WIDTH="41%" VALIGN="TOP">
<P>&nbsp;</TD>
<TD WIDTH="26%" VALIGN="TOP">
<P>&nbsp;</TD>
</TR>
<TR><TD WIDTH="33%" VALIGN="TOP">
<P>&nbsp;</TD>
<TD WIDTH="41%" VALIGN="TOP">
<P>&nbsp;</TD>
<TD WIDTH="26%" VALIGN="TOP">
<P>&nbsp;</TD>
</TR>
<TR><TD WIDTH="33%" VALIGN="TOP">
<U><P>&#9;*&#9;</U></TD>
<TD WIDTH="41%" VALIGN="TOP">
<P><FONT SIZE=2>Director</TD>
<TD WIDTH="26%" VALIGN="TOP">
<P><FONT SIZE=2>December 20, 2002</TD>
</TR>
<TR><TD WIDTH="33%" VALIGN="TOP">
<P><FONT SIZE=2>Stewart Carrell</TD>
<TD WIDTH="41%" VALIGN="TOP">
<P>&nbsp;</TD>
<TD WIDTH="26%" VALIGN="TOP">
<P>&nbsp;</TD>
</TR>
<TR><TD WIDTH="33%" VALIGN="TOP">
<P>&nbsp;</TD>
<TD WIDTH="41%" VALIGN="TOP">
<P>&nbsp;</TD>
<TD WIDTH="26%" VALIGN="TOP">
<P>&nbsp;</TD>
</TR>
<TR><TD WIDTH="33%" VALIGN="TOP">
<U><P>&#9;*&#9;</U></TD>
<TD WIDTH="41%" VALIGN="TOP">
<P><FONT SIZE=2>Director</TD>
<TD WIDTH="26%" VALIGN="TOP">
<P><FONT SIZE=2>December 20, 2002</TD>
</TR>
<TR><TD WIDTH="33%" VALIGN="TOP">
<P><FONT SIZE=2>Ferid Murad</TD>
<TD WIDTH="41%" VALIGN="TOP">
<P>&nbsp;</TD>
<TD WIDTH="26%" VALIGN="TOP">
<P>&nbsp;</TD>
</TR>
<TR><TD WIDTH="33%" VALIGN="TOP">
<P>&nbsp;</TD>
<TD WIDTH="41%" VALIGN="TOP">
<P>&nbsp;</TD>
<TD WIDTH="26%" VALIGN="TOP">
<P>&nbsp;</TD>
</TR>
<TR><TD WIDTH="33%" VALIGN="TOP">
<U><P>&#9;*&#9;</U></TD>
<TD WIDTH="41%" VALIGN="TOP">
<P><FONT SIZE=2>Director</TD>
<TD WIDTH="26%" VALIGN="TOP">
<P><FONT SIZE=2>December 20, 2002</TD>
</TR>
<TR><TD WIDTH="33%" VALIGN="TOP">
<P><FONT SIZE=2>Alfred Alberts</TD>
<TD WIDTH="41%" VALIGN="TOP">
<P>&nbsp;</TD>
<TD WIDTH="26%" VALIGN="TOP">
<P>&nbsp;</TD>
</TR>
</TABLE>

<P ALIGN="JUSTIFY">&nbsp;</P>
<P>&nbsp;</P>
<P>*By <U><FONT SIZE=2>/s/ John P. McAlister</U></P>
</U><P><FONT SIZE=2>John P. McAlister</P>
<P><FONT SIZE=2>Attorney-in-fact</P>
<P><FONT SIZE=2>John P. McAlister, by signing his name hereto, does sign this document on behalf of the individuals named above, pursuant to a power of attorney duly executed by such individuals, previously filed as Exhibit 24 to the Registration Statement on Form S-8 filed on August 19, 1998. </P>
<U><P ALIGN="JUSTIFY">&nbsp;</P>
<P ALIGN="JUSTIFY">&nbsp;</P>
<P ALIGN="CENTER">EXHIBIT INDEX</P>
<P ALIGN="JUSTIFY">Exhibit No.</U>&#9;</P>
<TABLE CELLSPACING=0 BORDER=0 CELLPADDING=14 WIDTH=698>
<TR><TD WIDTH="93%" VALIGN="TOP">
<P ALIGN="JUSTIFY"><FONT SIZE=2>4.1&#9;Amended and Restated Articles of Incorporation, dated January 26, 1996, incorporated by reference to the Registrant's Annual Report on Form 10-K for the fiscal year ended December 31, 1995. &#9;</P>
<P ALIGN="JUSTIFY"><FONT SIZE=2>4.2&#9;Articles of Amendment to the Articles of Incorporation, dated February 4, 2000, incorporated by reference to Exhibit 3.3 to the Registrant's Annual Report on Form 10-K for the fiscal year ended December 31, 2000. </P>
<P ALIGN="JUSTIFY"><FONT SIZE=2>4.3&#9;Amended and Restated Bylaws, incorporated by reference to the Registrant's Registration Statement on Form 10 dated May 27, 1994.</P>
<P ALIGN="JUSTIFY"><FONT SIZE=2>4.4&#9;Investor's Rights Agreement, dated February 4, 2000, between LION bioscience AG and Tripos, Inc., incorporated by reference to Exhibit 4.1 to the Registrant's Annual Report on Form 10-K for the fiscal year ended December 31, 1999. </P>
<P ALIGN="JUSTIFY"><FONT SIZE=2>4.5&#9;Rights Agreement, dated January 26, 1996, between Tripos, Inc. and Boatmen's Trust Company, as Rights Agent, incorporated by reference to the Registrant's Annual Report on Form 10-K for the fiscal year ended December 31, 1995. </P>
<P ALIGN="JUSTIFY"><FONT SIZE=2>5.1&#9;Opinion of Wilson, Sonsini, Goodrich &amp; Rosati, PC as to the legality of the securities being registered.*</P>
<P ALIGN="JUSTIFY"><FONT SIZE=2>23.1&#9;Consent of Ernst &amp; Young LLP.*</P>
<P ALIGN="JUSTIFY"><FONT SIZE=2>23.2&#9;Consent of Counsel (included in Exhibit 5.1).</P>
<P ALIGN="JUSTIFY"><FONT SIZE=2>24.1 &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Power of Attorney.**</P>
<P ALIGN="JUSTIFY"><FONT SIZE=2>99.1 &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;1994 Director Stock Option Plan</P>
<P ALIGN="JUSTIFY"><FONT SIZE=2>99.2  &nbsp;&nbsp;&nbsp;&nbsp;Form of Option Agreement</P>
<P ALIGN="JUSTIFY">________________</P>
<P ALIGN="JUSTIFY">*&#9;Filed herewith</P>
<P ALIGN="JUSTIFY">** Previously filed</TD>
<TD WIDTH="7%" VALIGN="TOP">
<P>&nbsp;</TD>
</TR>
<TR><TD WIDTH="93%" VALIGN="TOP">
<P>&nbsp;</TD>
<TD WIDTH="7%" VALIGN="TOP">
<P>&nbsp;</TD>
</TR>
</TABLE>

<P ALIGN="JUSTIFY">&nbsp;</P>
<P ALIGN="JUSTIFY">&nbsp;</P>
<P ALIGN="JUSTIFY">&nbsp;</P>
<B><P ALIGN="JUSTIFY">Exhibit 5.1</P>
</B><P ALIGN="CENTER">December 19, 2002</P>
<P>&#9;</P>
<P>Tripos, Inc.</P>
<P>1699 South Hanley Road</P>
<P>Suite 303</P>
<P>St. Louis, MO 63144&#9;</P>
<P>&#9;<U>Re: Registration Statement on Form S-8</P>
</U><P>Ladies and Gentlemen:</P>
<P>&#9;We have examined the Registration Statement on Form S-8 to be filed by you with the Securities and Exchange Commission on or about December 19, 2002 (the "<I>Registration Statement"</I>) in connection with the registration under the Securities Act of 1933, as amended, of the 1994 Director Stock Option Plan (as to 120,000 additional shares) (the "<I>Plan</I>" and the "<I>Shares</I>" as appropriate). As legal counsel for Tripos, Inc., we have examined the proceedings taken and are familiar with the proceedings proposed to be taken by you in connection with the sale and issuance of the Shares pursuant to the Plan.</P>
<P>&#9;It is our opinion that the Shares, when issued and sold in the manner described in the Plan and pursuant to the agreement that accompanies each grant under the Plan, will be legally and validly issued, fully paid and non assessable.</P>
<P>&#9;We consent to the use of this opinion as an exhibit to the Registration Statement and further consent to the use of our name wherever appearing in the Registration Statement and any amendments thereto.</P>
<P ALIGN="CENTER">&#9;</P>
<P>&#9;&#9;&#9;&#9;Very truly yours,</P>
<P>&#9;&#9;&#9;&#9;Wilson Sonsini Goodrich &amp; Rosati</P>
<P>&#9;&#9;&#9;&#9;Professional Corporation</P>
<P ALIGN="JUSTIFY">&nbsp;</P>
<P>&nbsp;</P>
<B><P>Exhibit 23.1</P>
</B><P>&nbsp;</P>
<P ALIGN="CENTER">Consent of Independent Auditors</P>
<P ALIGN="JUSTIFY">We consent to the incorporation by reference in Registration Statement (Form S-8 No. 333-______) pertaining to the Tripos, Inc. 1994 Director Stock Option Plan of our report dated February 5, 2002 (except Notes 16 and 18, as to which the date is February 8, 2002), with respect to the consolidated financial statements and schedule of Tripos, Inc. included in its Annual Report (Form 10-K) for the year ended December 31, 2001, filed with the Securities and Exchange Commission.</P>
<P ALIGN="JUSTIFY">&nbsp;</P>
<P ALIGN="JUSTIFY">/s/ Ernst and Young, LLP </P>
<P ALIGN="JUSTIFY">St. Louis, Missouri</P>
<P>December 19, 2002</P>
<P ALIGN="JUSTIFY">&nbsp;</P></BODY>
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MBI/FFB Amendment No. 2 on Form S-8 to Form S-4
As Filed With the Securities and Exchange Commission on December 20, 2002
Registration No.
333-_______
UNITED STATES
SECURITIES AND EXCHANGE COMMISSION
Washington, D. C. 20549
_______________________
FORM S-8
Registration Statement Under
The Securities Act of 1933
________________________
TRIPOS, INC.
(Exact name of registrant as specified in its charter)
Utah
43-1454986
(State or other jurisdiction of
(I.R.S. Employer
incorporation or organization)
Identification No.)
1699 South Hanley Road
St. Louis, Missouri 63144
(Address of Principal Executive Offices)
_________________________
TRIPOS, INC. 1994 DIRECTOR STOCK OPTION PLAN
(Full title of the plans)
Dr.
John P. McAlister
President and Chief Executive Officer
Tripos, Inc.
1699 South Hanley Road
St. Louis, Missouri 63144
(Name and address of agent for service)
Telephone number, including area code, of agent for service:
(314) 647-1099
________________________
Copies to:
Roger D. Stern, Esq.
Wilson Sonsini Goodrich & Rosati, PC
950 Page Mill Road
Palo Alto, California 94304
CALCULATION OF REGISTRATION FEE
Title of each class of
securities to be registered
Amount to be registered
(2)
Proposed maximum offering price per unit
(3)
Proposed maximum aggregate offering price
(3)
Amount of registration fee
Common Stock, $.005 par value
(1)
120,000
$7.26
$871,200
$80.15
(1)	Includes one attached preferred stock purchase right per share.
(2)	The shares being registered hereby are reserved for issuance pursuant to the Tripos, Inc. 1994 Director Stock Option Plan.
(3)	Estimated solely for purposes of computing the Registration Fee pursuant to the provisions of Rule 457(h), based upon a price of $7.26 per share, being the average of the high and low transaction prices of the Registrant's common stock per share as reported on the Nasdaq National Market on December 19, 2002.
TRIPOS, INC.
1994 DIRECTOR STOCK OPTION PLAN
EXPLANATORY NOTE
This Registration Statement on Form S-8 is being filed by Tripos, Inc. in connection with the registration of an additional 120,000 shares of common stock, $.005 par value per share, to be issued pursuant to the Tripos, Inc. 1994 Director Stock Option Plan. The contents of the Registration Statement on Form S-8 (Reg. No. 333-61829) filed by Tripos, Inc. with the Securities and Exchange Commission on August 19, 1998, other than Item 5, are incorporated herein by reference.
Item 5. 	Not Applicable.
Item 8.
Exhibits
.
See Exhibit Index located at page 5 hereof.
SIGNATURES
Pursuant to the requirements of the Securities Act of 1933, the Registrant certifies that it has reasonable grounds to believe that it meets all of the requirements for filing on Form S-8 and has duly caused this Amendment No. 1
to Registration Statement (File No. 333-______) to be signed on its behalf by the undersigned, thereunto duly authorized, in the County of St. Louis, State of Missouri, on the 20
th
day of December 2002.
TRIPOS, INC.
By:
/s/ John P. McAlister
John P. McAlister
President and Chief Executive Officer
Pursuant to the requirements of the Securities Act of 1933, this Registration Statement has been signed by the following persons in the capacities and on the dates indicated.
Signature
Title
Date
/s/ John P. McAlister
President, Chief Executive
December 20, 2002
John P. McAlister
Officer and Director
Principal Executive Officer
/s/ B. James Rubin
Senior Vice President, Chief
December 20, 2002
B. James Rubin
Financial Officer and Secretary
Principal Financial Officer
/s/ John D. Yingling
Vice President, Chief Accounting
December 20, 2002
John D. Yingling
Officer and Assistant Secretary
Principal Accounting Officer
*
Chairman of the Board
December 20, 2002
Ralph S. Lobdell
of Directors
*
Director
December 20, 2002
Gary Meredith
*
Director
December 20, 2002
Stewart Carrell
*
Director
December 20, 2002
Ferid Murad
*
Director
December 20, 2002
Alfred Alberts
*By
/s/ John P. McAlister
John P. McAlister
Attorney-in-fact
John P. McAlister, by signing his name hereto, does sign this document on behalf of the individuals named above, pursuant to a power of attorney duly executed by such individuals, previously filed as Exhibit 24 to the Registration Statement on Form S-8 filed on August 19, 1998.
EXHIBIT INDEX
Exhibit No.
4.1	Amended and Restated Articles of Incorporation, dated January 26, 1996, incorporated by reference to the Registrant's Annual Report on Form 10-K for the fiscal year ended December 31, 1995.
4.2	Articles of Amendment to the Articles of Incorporation, dated February 4, 2000, incorporated by reference to Exhibit 3.3 to the Registrant's Annual Report on Form 10-K for the fiscal year ended December 31, 2000.
4.3	Amended and Restated Bylaws, incorporated by reference to the Registrant's Registration Statement on Form 10 dated May 27, 1994.
4.4	Investor's Rights Agreement, dated February 4, 2000, between LION bioscience AG and Tripos, Inc., incorporated by reference to Exhibit 4.1 to the Registrant's Annual Report on Form 10-K for the fiscal year ended December 31, 1999.
4.5	Rights Agreement, dated January 26, 1996, between Tripos, Inc. and Boatmen's Trust Company, as Rights Agent, incorporated by reference to the Registrant's Annual Report on Form 10-K for the fiscal year ended December 31, 1995.
5.1	Opinion of Wilson, Sonsini, Goodrich & Rosati, PC as to the legality of the securities being registered.*
23.1	Consent of Ernst & Young LLP.*
23.2	Consent of Counsel (included in Exhibit 5.1).
24.1      Power of Attorney.**
99.1      1994 Director Stock Option Plan
99.2      Form of Option Agreement
________________
*	Filed herewith
** Previously filed
Exhibit 5.1
December 19, 2002
Tripos, Inc.
1699 South Hanley Road
Suite 303
St. Louis, MO 63144
Re: Registration Statement on Form S-8
Ladies and Gentlemen:
We have examined the Registration Statement on Form S-8 to be filed by you with the Securities and Exchange Commission on or about December 19, 2002 (the "
Registration Statement"
) in connection with the registration under the Securities Act of 1933, as amended, of the 1994 Director Stock Option Plan (as to 120,000 additional shares) (the "
Plan
" and the "
Shares
" as appropriate). As legal counsel for Tripos, Inc., we have examined the proceedings taken and are familiar with the proceedings proposed to be taken by you in connection with the sale and issuance of the Shares pursuant to the Plan.
It is our opinion that the Shares, when issued and sold in the manner described in the Plan and pursuant to the agreement that accompanies each grant under the Plan, will be legally and validly issued, fully paid and non assessable.
We consent to the use of this opinion as an exhibit to the Registration Statement and further consent to the use of our name wherever appearing in the Registration Statement and any amendments thereto.
Very truly yours,
Wilson Sonsini Goodrich & Rosati
Professional Corporation
Exhibit 23.1
Consent of Independent Auditors
We consent to the incorporation by reference in Registration Statement (Form S-8 No. 333-______) pertaining to the Tripos, Inc. 1994 Director Stock Option Plan of our report dated February 5, 2002 (except Notes 16 and 18, as to which the date is February 8, 2002), with respect to the consolidated financial statements and schedule of Tripos, Inc. included in its Annual Report (Form 10-K) for the year ended December 31, 2001, filed with the Securities and Exchange Commission.
/s/ Ernst and Young, LLP
St. Louis, Missouri
December 19, 2002