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    <div style="text-align: center; font-family: 'Times New Roman', Times, serif; font-size: 10pt; font-weight: bold;">As filed with the Securities and Exchange Commission on February 22, 2019</div>
    <div style="text-align: right;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif; font-weight: bold;">Registration No. 333-_____</font></div>
    <div style="text-align: justify;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">&#160;</font></div>
    <div style="text-align: center;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif; font-weight: bold;">UNITED STATES</font></div>
    <div style="text-align: center;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif; font-weight: bold;">SECURITIES AND EXCHANGE COMMISSION</font></div>
    <div style="text-align: center;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif; font-weight: bold;">Washington, D.C. 20549</font></div>
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        Times, serif; font-weight: bold;"> </font></div>
    <div style="text-align: center;"><font style="font-size: 18pt; font-family: 'Times New Roman', Times, serif; font-weight: bold;">FORM S-8</font></div>
    <div style="text-align: center;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif; font-weight: bold;">REGISTRATION STATEMENT</font></div>
    <div style="text-align: center;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif; font-weight: bold;">UNDER THE SECURITIES ACT OF 1933</font>
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    <div style="text-align: justify;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">&#160;</font></div>
    <div style="text-align: center;"><font style="font-size: 18pt; font-family: 'Times New Roman', Times, serif; font-weight: bold;">AngioDynamics, Inc.</font></div>
    <div style="text-align: center;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif; font-weight: bold;">(Exact Name of Registrant as Specified in Its Charter)</font></div>
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            <div style="text-align: center;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif; font-weight: bold;">Delaware</font></div>
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          <td style="width: 50%; vertical-align: top; background-color: #FFFFFF;">
            <div style="text-align: center;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif; font-weight: bold;">11-3146460</font></div>
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            <div style="text-align: center;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">(State or Other Jurisdiction of Incorporation or Organization)</font></div>
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            <div style="text-align: center;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">(I.R.S. Employer Identification No.)</font></div>
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    <div style="text-align: justify;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">&#160;</font></div>
    <div style="text-align: center;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif; font-weight: bold;">14 Plaza Drive</font></div>
    <div style="text-align: center;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif; font-weight: bold;">Latham, New York 12110</font></div>
    <div style="text-align: center;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">(Address of Principal Executive Offices) (Zip Code)</font></div>
    <div style="text-align: justify;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">&#160;</font></div>
    <div style="text-align: center;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif; font-weight: bold;">AngioDynamics, Inc. 2004 Stock and Incentive Award Plan (as amended)</font></div>
    <div style="text-align: center;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif; font-weight: bold;">AngioDynamics, Inc. Employee Stock Purchase Plan (as amended)</font></div>
    <div style="text-align: center;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">(Full Title of the Plan)</font></div>
    <div style="text-align: justify;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">&#160;</font></div>
    <div style="text-align: center;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif; font-weight: bold;">Stephen A. Trowbridge, Esq.</font></div>
    <div style="text-align: center;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif; font-weight: bold;">Senior Vice President and General Counsel</font></div>
    <div style="text-align: center;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif; font-weight: bold;">AngioDynamics, Inc.</font></div>
    <div style="text-align: center;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif; font-weight: bold;">14 Plaza Drive</font></div>
    <div style="text-align: center;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif; font-weight: bold;">Latham, New York 12110</font></div>
    <div style="text-align: center;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif; font-weight: bold;">(518) 795-1400</font></div>
    <div style="text-align: center;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">(Name, Address and Telephone Number,</font></div>
    <div style="text-align: center;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">including Area Code, of Agent for Service)</font></div>
    <div style="text-align: center;">
      <hr noshade="noshade" align="center" style="height: 1px; width: 25%; color: #000000; background-color: #000000; text-align: center; margin-left: auto; margin-right: auto; border: none;"><font style="font-size: 10pt; font-family: 'Times New Roman',
        Times, serif;"> </font></div>
    <div style="text-align: left;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, a smaller reporting
        company or an emerging growth company. See the definitions of &#8220;large accelerated filer,&#8221; &#8220;accelerated filer,&#8221; &#8220;smaller reporting company,&#8221; and &#8220;emerging growth company&#8221; in Rule 12b-2 of the Exchange Act.</font></div>
    <div style="text-align: justify;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">&#160;</font></div>
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            <div style="text-align: left;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">&#160;</font></div>
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            <div style="text-align: left;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">&#160;</font></div>
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          <td style="width: 47.37%; vertical-align: middle; background-color: #FFFFFF;">
            <div style="text-align: left;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">&#160;</font></div>
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            <div style="text-align: center;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">Large accelerated filer <font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">&#9744;</font></font></div>
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            <div style="text-align: left;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">&#160;</font></div>
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            <div style="text-align: center;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">Accelerated filer <font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">&#9746;</font></font></div>
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            <div style="text-align: center;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">Non-accelerated filer <font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">&#9744;</font></font></div>
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          <td style="width: 5.27%; vertical-align: bottom; background-color: #FFFFFF;">
            <div style="text-align: left;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">&#160;</font></div>
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          <td style="width: 47.37%; vertical-align: bottom; background-color: #FFFFFF;">
            <div style="text-align: center;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">Smaller reporting company <font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">&#9744;</font></font></div>
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          <td style="width: 5.27%; vertical-align: bottom; background-color: #FFFFFF;">&#160;</td>
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            <div style="text-align: center;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">Emerging growth company <font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">&#9744;</font></font></div>
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    <div style="text-align: justify; margin-right: 9pt;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition
        period for complying with any new or revised financial accounting standards provided pursuant to Section 7(a)(2)(B) of the Securities Act. </font><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;"><font style="font-size:
          10pt; font-family: 'Times New Roman', Times, serif;">&#9744;</font></font></div>
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    <div style="text-align: center;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif; font-weight: bold;">CALCULATION OF REGISTRATION FEE</font></div>
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            <div style="text-align: center;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif; font-weight: bold;">Title of Securities</font></div>
            <div style="text-align: center;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif; font-weight: bold;">to be Registered</font></div>
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            <div style="text-align: center;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif; font-weight: bold;">Amount to be</font></div>
            <div style="text-align: center;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif; font-weight: bold;">Registered(1)</font></div>
          </td>
          <td style="background-color: #FFFFFF; border-top: 4px solid #000000; vertical-align: bottom; width: 22.76%;">
            <div style="text-align: center;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif; font-weight: bold;">Proposed Maximum Offering</font></div>
            <div style="text-align: center;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif; font-weight: bold;">Price Per Share(2)</font></div>
          </td>
          <td style="background-color: #FFFFFF; border-top: 4px solid #000000; vertical-align: bottom; width: 20.28%;">
            <div style="text-align: center;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif; font-weight: bold;">Proposed Maximum</font></div>
            <div style="text-align: center;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif; font-weight: bold;">Aggregate Offering Price(2)</font></div>
          </td>
          <td style="background-color: #FFFFFF; border-top: 4px solid #000000; vertical-align: bottom; width: 15.3%;">
            <div style="text-align: center;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif; font-weight: bold;">Amount of</font></div>
            <div style="text-align: center;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif; font-weight: bold;">Registration Fee(2)</font></div>
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            <div style="text-align: left; text-indent: -18pt; margin-left: 18pt;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">Common Stock, par value $0.01 per share</font></div>
          </td>
          <td style="background-color: #FFFFFF; border-bottom: 4px solid #000000; vertical-align: bottom; width: 12.65%;">
            <div style="text-align: center;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">2,500,000 shares(3)</font></div>
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            <div style="text-align: center;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">$23.32</font></div>
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            <div style="text-align: center;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">$58,300,000</font></div>
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            <div style="text-align: center;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">$7,065.96</font></div>
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            <div style="text-align: left;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">(1)</font></div>
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          <td style="width: 96.43%; vertical-align: top; background-color: #FFFFFF;">
            <div style="text-align: justify;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">Pursuant to Rule 416 under the Securities Act of 1933, as amended (the &#8220;Securities Act&#8221;), this Registration Statement also covers an
                indeterminate number of additional shares of common stock, par value $0.01 per share, of AngioDynamics, Inc. (&#8220;Common Stock&#8221;) that may become issuable under the AngioDynamics, Inc. 2004 Stock and Incentive Award Plan, as amended, and the
                AngioDynamics, Inc. Employee Stock Purchase Plan, as amended, by reason of any stock dividend, stock split, recapitalization or any other similar transaction.</font></div>
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            <div style="text-align: left;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">(2)</font></div>
          </td>
          <td style="width: 96.43%; vertical-align: top; background-color: #FFFFFF;">
            <div style="text-align: left;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">Pursuant to Rule 457 under the Securities Act, the proposed maximum aggregate offering price and the registration fee are estimated
                based upon the average of the high and low sale prices of the Common Stock as reported on The Nasdaq Global Select Market on Febrary 15</font><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">, 2019.</font></div>
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            <div style="text-align: left;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">(3)</font></div>
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            <div style="text-align: justify;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">This number consists of (i) 1,000,000 shares of Common Stock available for issuance under the AngioDynamics, Inc. 2004 Stock and
                Incentive Award Plan, as amended, and (ii) 1,500,000 shares of Common Stock available for issuance under the AngioDynamics, Inc. Employee Stock Purchase Plan, as amended.</font></div>
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    <div style="text-align: center;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif; font-weight: bold;">EXPLANATORY NOTE</font></div>
    <div style="text-align: justify;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">&#160;</font></div>
    <div style="text-align: justify; text-indent: 27pt;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">This Registration Statement on Form S-8 (this &#8220;Registration Statement&#8221;) is filed with the Securities and Exchange
        Commission (the &#8220;SEC&#8221;) by AngioDynamics, Inc., a Delaware corporation (the &#8220;Registrant&#8221;), in order to register (i) an additional 1,000,000 shares of the Registrant&#8217;s common stock, par value $0.01 per share (&#8220;Common Stock&#8221;), available for issuance
        under the AngioDynamics, Inc. 2004 Stock and Incentive Award Plan, as amended (the &#8220;2004 Plan&#8221;), and (ii) an additional 1,500,000 shares of Common Stock available for issuance under the AngioDynamics, Inc. Employee Stock Purchase Plan, as amended
        (the &#8220;Purchase Plan&#8221; and, together with the 2004 Plan, the &#8220;Plans&#8221;).</font></div>
    <div style="text-align: justify;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">&#160;</font></div>
    <div style="text-align: justify; text-indent: 27pt;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">On October 28, 2004, the Registrant filed with the SEC a Registration Statement on Form S-8 (File No. 333-120057) to
        register 1,000,000 shares of Common Stock issuable under the 2004 Plan and 200,000 shares of Common Stock issuable under the Purchase Plan (the &#8220;2004 Registration Statement&#8221;). On November 6, 2006, the Registrant filed with the SEC a Registration
        Statement on Form S-8 (File No. 333-138456) to register an additional 1,000,000 shares of Common Stock issuable under the 2004 Plan (the &#8220;2006 Registration Statement&#8221;). On August 14, 2009, the Registrant filed with the SEC a Registration Statement
        on Form S-8 (File No. 333-161355) to register an additional 1,000,000 shares of Common Stock issuable under the 2004 Plan and an additional 200,000 shares of Common Stock issuable under the Purchase Plan (the &#8220;August 2009 Registration Statement&#8221;).
        On November 3, 2009, the Registrant filed with the SEC a Registration Statement on Form S-8 (File No. 333-162844) to register an additional 750,000 shares of Common Stock issuable under the 2004 Plan (the &#8220;November 2009 Registration Statement&#8221;). On
        November 16, 2010, the Registrant filed with the SEC a Registration Statement on Form S-8 (File No. 333-170619) to register an additional 300,000 shares of Common Stock issuable under the Purchase Plan (the &#8220;2010 Registration Statement&#8221;). On August
        15, 2013, the Registrant filed with the SEC a Registration Statement on Form S-8 (File No. 333-190640) to register an additional 2,000,000 shares of Common Stock issuable under the 2004 Plan and an additional 500,000 shares of Common Stock issuable
        under the Purchase Plan (the &#8220;2013 Registration Statement&#8221;). On April 16, 2015, the Registrant filed with the SEC a Registration Statement on Form S-8 (File No. 333-203441) to register an additional 1,000,000 shares of Common Stock issuable under
        the 2004 Plan and an additional 800,000 shares of Common Stock issuable under the Purchase Plan (the &#8220;2015 Registration Statement&#8221;).</font></div>
    <div style="text-align: justify;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">&#160;</font></div>
    <div style="text-align: justify; text-indent: 27pt;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">On October 25, 2016, the stockholders of the Registrant approved (i) an amendment to the 2004 Plan to increase the number
        of shares of Common Stock issuable under the 2004 Plan from 6,750,000 to 7,000,000 shares and (ii) an amendment to the Purchase Plan to increase the number of shares of Common Stock issuable under the Purchase Plan from 2,000,000 to 2,500,000
        shares (collectively, the &#8220;2016 Share Increases&#8221;). On October 10, 2018, the stockholders of the Registrant approved (i) an amendment to the 2004 Plan to increase the number of shares of Common Stock issuable under the 2004 Plan from 7,000,000 to
        7,750,000 shares and (ii) an amendment to the Purchase Plan to increase the number of shares of Common Stock issuable under the Purchase Plan from 2,500,000 to 3,500,000 shares (collectively, the &#8220;2018 Share Increases&#8221;). This Registration Statement
        is being filed to register the additional 1,000,000 shares of Common Stock issuable under the 2004 Plan and the additional 1,500,000 shares of Common Stock issuable under the Purchase Plan as approved by the stockholders of the Registrant pursuant
        to the 2016 Share Increases and the 2018 Share Increases.</font></div>
    <div style="text-align: justify;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">&#160;</font></div>
    <div style="text-align: justify; text-indent: 27pt;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">Pursuant to General Instruction E to Form S-8, this Registration Statement incorporates by reference the contents of the
        2004 Registration Statement, the 2006 Registration Statement, the August 2009 Registration Statement, the November 2009 Registration Statement, the 2010 Registration Statement, the 2013 Registration Statement and the 2015 Registration Statement,
        including, with respect to each registration statement, each of the documents filed by the Registrant with the SEC and incorporated or deemed to be incorporated by reference therein and including each of the documents filed as exhibits to such
        registration statement, except as otherwise updated or modified in this Registration Statement.</font></div>
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    </div>
    <div style="text-align: center;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;"> <br>
      </font></div>
    <div style="text-align: center;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif; font-weight: bold;">PART II</font></div>
    <div style="text-align: center;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif; font-weight: bold;">INFORMATION REQUIRED IN THE REGISTRATION STATEMENT</font></div>
    <div style="text-align: justify;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">&#160;</font></div>
    <table cellspacing="0" cellpadding="0" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%;" id="zec3e10372db647d2a158666996b5fc01">

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          <td style="width: 14.29%; vertical-align: top; background-color: #FFFFFF;">
            <div style="text-align: left;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif; font-weight: bold;">Item 3.</font></div>
          </td>
          <td style="width: 85.71%; vertical-align: top; background-color: #FFFFFF;">
            <div style="text-align: left;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif; font-weight: bold;">Incorporation of Documents by Reference.</font></div>
          </td>
        </tr>

    </table>
    <div style="text-align: justify;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">&#160;</font></div>
    <div style="text-align: justify; text-indent: 27pt;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">The following documents filed by the Registrant with the SEC pursuant to Section 13 of the Securities Exchange Act of
        1934, as amended (the &#8220;Exchange Act&#8221;) (File No. 000-50761), are incorporated herein by reference: (i) the Annual Report on Form 10-K (including the portions of the Registrant&#8217;s Proxy Statement incorporated by reference therein) for the fiscal year
        ended May 31, 2018, filed with the SEC on July 23, 2018; (ii) the Quarterly Reports on Form 10-Q for the fiscal periods ended August 31, 2018 and November 30, 2018, filed with the SEC on October 1, 2018 and January 7, 2019, respectively; (iii) the
        Current Report on Form 8-K filed with the SEC on October 12, 2018; and (iv) the description of the Common Stock contained in the Registrant&#8217;s registration statement on Form 8-A (Registration No. 000-50761), filed by the Registrant with the SEC
        under Section 12(b) of the Exchange Act on May 13, 2004, including any amendments or reports filed for the purpose of updating such description. All documents filed by the Registrant pursuant to Sections 13(a), 13(c), 14 or 15(d) of the Exchange
        Act subsequent to the date of this Registration Statement and prior to the filing of a post-effective amendment indicating that all securities offered hereby have been sold or deregistering all securities then remaining unsold, shall be deemed to
        be incorporated by reference into this Registration Statement and to be a part hereof from the date of filing of such documents.</font></div>
    <div style="text-align: justify;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">&#160;</font></div>
    <table cellspacing="0" cellpadding="0" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%;" id="z029724ea3d93453cbb548af75f14c7de">

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          <td style="width: 14.29%; vertical-align: top; background-color: #FFFFFF;">
            <div style="text-align: left;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif; font-weight: bold;">Item 5.</font></div>
          </td>
          <td style="width: 85.71%; vertical-align: top; background-color: #FFFFFF;">
            <div style="text-align: left;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif; font-weight: bold;">Interests of Named Experts and Counsel.</font></div>
          </td>
        </tr>

    </table>
    <div style="text-align: justify;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">&#160;</font></div>
    <div style="text-align: justify; text-indent: 27pt;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">Stephen A. Trowbridge, who is providing an opinion on the validity of the issuance of the shares of Common Stock being
        registered hereby, is Senior Vice President and General Counsel of the Registrant. As an employee of the Registrant, Mr. Trowbridge participates in equity compensation plans of the Registrant on the same basis as other similarly eligible employees,
        pursuant to which Mr. Trowbridge owns or has options or rights to acquire an aggregate of less than 1% of the Registrant&#8217;s outstanding Common Stock. Mr. Trowbridge is eligible to participate in the Plans.</font></div>
    <div style="text-align: justify;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">&#160;</font></div>
    <table cellspacing="0" cellpadding="0" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%;" id="zd2950870edf5414bbd060a1ad5faac76">

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          <td style="width: 14.29%; vertical-align: top; background-color: #FFFFFF;">
            <div style="text-align: left;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif; font-weight: bold;">Item 8.</font></div>
          </td>
          <td style="width: 85.71%; vertical-align: top; background-color: #FFFFFF;">
            <div style="text-align: left;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif; font-weight: bold;">Exhibits.</font></div>
          </td>
        </tr>

    </table>
    <div style="text-align: justify;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">&#160;</font></div>
    <div><br>
    </div>
    <table cellspacing="0" cellpadding="0" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%;" id="z637fb7a4330749ea99f23aef561585eb">

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          <td style="width: 10.26%; vertical-align: bottom; background-color: #FFFFFF; border-bottom: #000000 2px solid;">
            <div style="text-align: left;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">EXHIBIT NUMBER</font></div>
          </td>
          <td style="width: 1.68%; vertical-align: top; background-color: #FFFFFF;">
            <div style="text-align: left;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">&#160;</font></div>
          </td>
          <td style="width: 88.07%; vertical-align: bottom; background-color: #FFFFFF; border-bottom: #000000 2px solid;">
            <div style="text-align: left;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">DESCRIPTION</font></div>
          </td>
        </tr>
        <tr>
          <td style="width: 10.26%; vertical-align: top; background-color: #FFFFFF;">
            <div style="text-align: left;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">3.1.1</font></div>
          </td>
          <td style="width: 1.68%; vertical-align: top; background-color: #FFFFFF;">
            <div style="text-align: left;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">&#160;</font></div>
          </td>
          <td style="width: 88.07%; vertical-align: top; background-color: #FFFFFF;">
            <div style="text-align: left;"><a href="http://www.sec.gov/Archives/edgar/data/1275187/000119312505198180/dex31.htm"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">Amended and Restated Certificate of Incorporation
                  of the Registrant.*</font></a></div>
          </td>
        </tr>
        <tr>
          <td style="width: 10.26%; vertical-align: top; background-color: #FFFFFF;">
            <div style="text-align: left;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">3.1.2</font></div>
          </td>
          <td style="width: 1.68%; vertical-align: top; background-color: #FFFFFF;">
            <div style="text-align: left;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">&#160;</font></div>
          </td>
          <td style="width: 88.07%; vertical-align: top; background-color: #FFFFFF;">
            <div style="text-align: left;"><a href="http://www.sec.gov/Archives/edgar/data/1275187/000127518715000018/ex31253115.htm"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">Certificate of Amendment to the Amended and
                  Restated Certificate of Incorporation of the Registrant.**</font></a></div>
          </td>
        </tr>
        <tr>
          <td style="width: 10.26%; vertical-align: top; background-color: #FFFFFF;">
            <div style="text-align: left;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">3.2</font></div>
          </td>
          <td style="width: 1.68%; vertical-align: top; background-color: #FFFFFF;">
            <div style="text-align: left;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">&#160;</font></div>
          </td>
          <td style="width: 88.07%; vertical-align: top; background-color: #FFFFFF;">
            <div style="text-align: left;"><a href="http://www.sec.gov/Archives/edgar/data/1275187/000091412115000548/an33460072-ex3_1.htm"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">Second Amended and Restated Bylaws of
                  the Registrant, effective October 16, 2015.***</font></a></div>
          </td>
        </tr>
        <tr>
          <td style="width: 10.26%; vertical-align: top; background-color: #FFFFFF;">
            <div style="text-align: left;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">4.2</font></div>
          </td>
          <td style="width: 1.68%; vertical-align: top; background-color: #FFFFFF;">
            <div style="text-align: left;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">&#160;</font></div>
          </td>
          <td style="width: 88.07%; vertical-align: top; background-color: #FFFFFF;">
            <div style="text-align: left;"><a href="http://www.sec.gov/Archives/edgar/data/1275187/000119312504079404/dex42.htm"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">Form of Specimen Certificate for the Registrant&#8217;s
                  Common Stock.****</font></a></div>
          </td>
        </tr>
        <tr>
          <td style="width: 10.26%; vertical-align: top; background-color: #FFFFFF;">
            <div style="text-align: left;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">5.1</font></div>
          </td>
          <td style="width: 1.68%; vertical-align: top; background-color: #FFFFFF;">
            <div style="text-align: left;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">&#160;</font></div>
          </td>
          <td style="width: 88.07%; vertical-align: top; background-color: #FFFFFF;">
            <div style="text-align: left;"><a href="an51708115_5-1.htm"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">Opinion of
                  Stephen A. Trowbridge, Senior Vice President and General Counsel of the Registrant.+</font></a></div>
          </td>
        </tr>
        <tr>
          <td style="width: 10.26%; vertical-align: top; background-color: #FFFFFF;">
            <div style="text-align: left;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">10.1</font></div>
          </td>
          <td style="width: 1.68%; vertical-align: top; background-color: #FFFFFF;">
            <div style="text-align: left;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">&#160;</font></div>
          </td>
          <td style="width: 88.07%; vertical-align: top; background-color: #FFFFFF;">
            <div style="text-align: left;"><a href="http://www.sec.gov/Archives/edgar/data/1275187/000127518718000016/angoproxy-53118.htm"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">AngioDynamics, Inc. 2004 Stock and
                  Incentive Award Plan, as amended.*****</font></a></div>
          </td>
        </tr>
        <tr>
          <td style="width: 10.26%; vertical-align: top; background-color: #FFFFFF;">
            <div style="text-align: left;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">10.2</font></div>
          </td>
          <td style="width: 1.68%; vertical-align: top; background-color: #FFFFFF;">
            <div style="text-align: left;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">&#160;</font></div>
          </td>
          <td style="width: 88.07%; vertical-align: top; background-color: #FFFFFF;">
            <div style="text-align: left;"><a href="http://www.sec.gov/Archives/edgar/data/1275187/000127518718000016/angoproxy-53118.htm"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">AngioDynamics, Inc. Employee Stock
                  Purchase Plan, as amended.******</font></a></div>
          </td>
        </tr>
        <tr>
          <td style="width: 10.26%; vertical-align: top; background-color: #FFFFFF;">
            <div style="text-align: left;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">23.1</font></div>
          </td>
          <td style="width: 1.68%; vertical-align: top; background-color: #FFFFFF;">
            <div style="text-align: left;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">&#160;</font></div>
          </td>
          <td style="width: 88.07%; vertical-align: top; background-color: #FFFFFF;">
            <div style="text-align: left;"><a href="an51708115_5-1.htm"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">Consent of
                  Stephen A. Trowbridge, Esq., Senior Vice President and General Counsel of the Registrant (included in Exhibit 5.1).+</font></a></div>
          </td>
        </tr>
        <tr>
          <td style="width: 10.26%; vertical-align: top; background-color: #FFFFFF;">
            <div style="text-align: left;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">23.2</font></div>
          </td>
          <td style="width: 1.68%; vertical-align: top; background-color: #FFFFFF;">
            <div style="text-align: left;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">&#160;</font></div>
          </td>
          <td style="width: 88.07%; vertical-align: top; background-color: #FFFFFF;">
            <div style="text-align: left;"><a href="an51708115_23-2.htm"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">Consent of
                  Deloitte &amp; Touche LLP.+</font></a></div>
          </td>
        </tr>
        <tr>
          <td style="width: 10.26%; vertical-align: top; background-color: #FFFFFF;" rowspan="1">23.3<br>
          </td>
          <td style="width: 1.68%; vertical-align: top; background-color: #FFFFFF;" rowspan="1">&#160;</td>
          <td style="width: 88.07%; vertical-align: top; background-color: #FFFFFF;" rowspan="1"><a href="an51708115_23-3.htm">Consent of PricewaterhouseCoopers
              LLP.+ </a><br>
          </td>
        </tr>
        <tr>
          <td style="width: 10.26%; vertical-align: top; background-color: #FFFFFF;">
            <div style="text-align: left;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">24.1</font></div>
          </td>
          <td style="width: 1.68%; vertical-align: top; background-color: #FFFFFF;">
            <div style="text-align: left;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">&#160;</font></div>
          </td>
          <td style="width: 88.07%; vertical-align: top; background-color: #FFFFFF;">
            <div style="text-align: left;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">Power of Attorney (included on signature page to this Registration Statement).+</font></div>
          </td>
        </tr>

    </table>
    <div style="text-align: justify;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">&#160;</font></div>
    <div>
      <hr noshade="noshade" align="left" style="height: 1px; width: 25%; color: #000000; background-color: #000000; text-align: left; margin-left: 0px; margin-right: auto; border: none;"></div>
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        <tr>
          <td style="width: 6.33%; vertical-align: top; background-color: #FFFFFF;">
            <div style="text-align: justify;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">*</font></div>
          </td>
          <td style="width: 93.67%; vertical-align: top; background-color: #FFFFFF;">
            <div style="text-align: justify;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">Incorporated by reference to Exhibit 3.1 to the Registrant&#8217;s Quarterly Report on Form 10-Q filed with the SEC on October 7, 2005.</font></div>
          </td>
        </tr>
        <tr>
          <td style="width: 6.33%; vertical-align: top; background-color: #FFFFFF;">
            <div style="text-align: justify;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">**</font></div>
          </td>
          <td style="width: 93.67%; vertical-align: top; background-color: #FFFFFF;">
            <div style="text-align: justify;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">Incorporated by reference to Exhibit 3.1.2 to the Registrant&#8217;s Annual Report on Form 10-K filed with the SEC on August 10, 2015.</font></div>
          </td>
        </tr>
        <tr>
          <td style="width: 6.33%; vertical-align: top; background-color: #FFFFFF;">
            <div style="text-align: justify;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">***</font></div>
          </td>
          <td style="width: 93.67%; vertical-align: top; background-color: #FFFFFF;">
            <div style="text-align: justify;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">Incorporated by reference to Exhibit 3.1 to the Registrant&#8217;s Current Report on Form 8-K filed with the SEC on October 21, 2015.</font></div>
          </td>
        </tr>
        <tr>
          <td style="width: 6.33%; vertical-align: top; background-color: #FFFFFF;">
            <div style="text-align: justify;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">****</font></div>
          </td>
          <td style="width: 93.67%; vertical-align: top; background-color: #FFFFFF;">
            <div style="text-align: justify;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">Incorporated by reference to Exhibit 4.2 to Amendment No. 2 to the Registrant&#8217;s Registration Statement on Form S-1 filed with the SEC
                on May 5, 2004.</font></div>
          </td>
        </tr>
        <tr>
          <td style="width: 6.33%; vertical-align: top; background-color: #FFFFFF;">
            <div style="text-align: justify;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">*****</font></div>
          </td>
          <td style="width: 93.67%; vertical-align: top; background-color: #FFFFFF;">
            <div style="text-align: justify;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">Incorporated by reference to Appendix A to the Registrant&#8217;s Definitive Proxy Statement on Schedule 14A filed with the SEC on August
                30, 2018.</font></div>
          </td>
        </tr>
        <tr>
          <td style="width: 6.33%; vertical-align: top; background-color: #FFFFFF;">
            <div style="text-align: justify;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">******</font></div>
          </td>
          <td style="width: 93.67%; vertical-align: top; background-color: #FFFFFF;">
            <div style="text-align: justify;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">Incorporated by reference to Appendix B to the Registrant&#8217;s Definitive Proxy Statement on Schedule 14A filed with the SEC on August
                30, 2018.</font></div>
          </td>
        </tr>
        <tr>
          <td style="width: 6.33%; vertical-align: top; background-color: #FFFFFF;">
            <div style="text-align: justify;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif; font-weight: bold;">+</font></div>
          </td>
          <td style="width: 93.67%; vertical-align: top; background-color: #FFFFFF;">
            <div style="text-align: justify;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">Filed herewith.</font></div>
          </td>
        </tr>

    </table>
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      <div style="page-break-after:always;" id="DSPFPageBreak">
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    </div>
    <div><br>
    </div>
    <div style="text-align: center;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif; font-weight: bold;">SIGNATURES</font></div>
    <div style="text-align: justify;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">&#160;</font></div>
    <div style="text-align: justify; text-indent: 27pt;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">Pursuant to the requirements of the Securities Act of 1933, the Registrant certifies that it has reasonable grounds to
        believe that it meets all of the requirements for filing on Form S-8 and has duly caused this Registration Statement to be signed on its behalf by the undersigned, thereunto duly authorized, in the City of Latham, State of New York, on February 22</font><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">, 2019.</font></div>
    <div style="text-align: justify; text-indent: 27pt;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">&#160;</font></div>
    <table cellspacing="0" cellpadding="0" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%;" id="z939c809f3142488c857c57a61e33789d">

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          <td style="width: 49.31%; vertical-align: top; background-color: #FFFFFF;">
            <div style="text-align: left;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">&#160;</font></div>
          </td>
          <td colspan="2" style="width: 39.98%; vertical-align: top; background-color: #FFFFFF;">
            <div style="text-align: left;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">ANGIODYNAMICS, INC.</font></div>
          </td>
          <td style="width: 10.71%; vertical-align: top; background-color: #FFFFFF;">
            <div style="text-align: left;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">&#160;</font></div>
          </td>
        </tr>
        <tr>
          <td style="width: 49.31%; vertical-align: top; background-color: #FFFFFF;">
            <div style="text-align: left;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">&#160;</font></div>
          </td>
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    <div style="text-align: justify; text-indent: 18pt;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">KNOW ALL MEN BY THESE PRESENTS, that each person whose signature appears below constitutes and appoints James C. Clemmer
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    <div style="text-align: justify; text-indent: 27pt;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">Pursuant to the requirements of the Securities Act of 1933, this Registration Statement has been signed by the following
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        <hr noshade="noshade" style="margin: 4px 0px; width: 100%; border-width: 0; height: 2px; color: #000000; background-color: #000000; clear: both;"></div>
    </div>
    <div style="text-align: center;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;"><u>EXHIBIT INDEX</u></font></font></div>
    <div style="text-align: justify;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">&#160;</font></div>
    <table cellspacing="0" cellpadding="0" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%;" id="zd97ee8dbc0e84f84840fb2268ce0c7e9">

        <tr>
          <td style="width: 10.25%; vertical-align: bottom; background-color: #FFFFFF; border-bottom: #000000 2px solid;">
            <div style="text-align: left;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">EXHIBIT NUMBER</font></div>
          </td>
          <td style="width: 1.68%; vertical-align: top; background-color: #FFFFFF;">
            <div style="text-align: left;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">&#160;</font></div>
          </td>
          <td style="width: 88.08%; vertical-align: bottom; background-color: #FFFFFF; border-bottom: #000000 2px solid;">
            <div style="text-align: left;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">DESCRIPTION</font></div>
          </td>
        </tr>
        <tr>
          <td style="width: 10.25%; vertical-align: top; background-color: #FFFFFF;">
            <div style="text-align: left;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">3.1.1</font></div>
          </td>
          <td style="width: 1.68%; vertical-align: top; background-color: #FFFFFF;">
            <div style="text-align: left;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">&#160;</font></div>
          </td>
          <td style="width: 88.08%; vertical-align: top; background-color: #FFFFFF;">
            <div style="text-align: left;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">Amended and Restated Certificate of Incorporation of the Registrant.*</font></div>
          </td>
        </tr>
        <tr>
          <td style="width: 10.25%; vertical-align: top; background-color: #FFFFFF;">
            <div style="text-align: left;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">3.1.2</font></div>
          </td>
          <td style="width: 1.68%; vertical-align: top; background-color: #FFFFFF;">
            <div style="text-align: left;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">&#160;</font></div>
          </td>
          <td style="width: 88.08%; vertical-align: top; background-color: #FFFFFF;">
            <div style="text-align: left;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">Certificate of Amendment to the Amended and Restated Certificate of Incorporation of the Registrant.**</font></div>
          </td>
        </tr>
        <tr>
          <td style="width: 10.25%; vertical-align: top; background-color: #FFFFFF;">
            <div style="text-align: left;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">3.2</font></div>
          </td>
          <td style="width: 1.68%; vertical-align: top; background-color: #FFFFFF;">
            <div style="text-align: left;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">&#160;</font></div>
          </td>
          <td style="width: 88.08%; vertical-align: top; background-color: #FFFFFF;">
            <div style="text-align: left;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">Second Amended and Restated Bylaws of the Registrant, effective October 16, 2015.***</font></div>
          </td>
        </tr>
        <tr>
          <td style="width: 10.25%; vertical-align: top; background-color: #FFFFFF;">
            <div style="text-align: left;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">4.2</font></div>
          </td>
          <td style="width: 1.68%; vertical-align: top; background-color: #FFFFFF;">
            <div style="text-align: left;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">&#160;</font></div>
          </td>
          <td style="width: 88.08%; vertical-align: top; background-color: #FFFFFF;">
            <div style="text-align: left;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">Form of Specimen Certificate for the Registrant&#8217;s Common Stock.****</font></div>
          </td>
        </tr>
        <tr>
          <td style="width: 10.25%; vertical-align: top; background-color: #FFFFFF;">
            <div style="text-align: left;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">5.1</font></div>
          </td>
          <td style="width: 1.68%; vertical-align: top; background-color: #FFFFFF;">
            <div style="text-align: left;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">&#160;</font></div>
          </td>
          <td style="width: 88.08%; vertical-align: top; background-color: #FFFFFF;">
            <div style="text-align: left;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">Opinion of Stephen A. Trowbridge, Senior Vice President and General Counsel of the Registrant.+</font></div>
          </td>
        </tr>
        <tr>
          <td style="width: 10.25%; vertical-align: top; background-color: #FFFFFF;">
            <div style="text-align: left;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">10.1</font></div>
          </td>
          <td style="width: 1.68%; vertical-align: top; background-color: #FFFFFF;">
            <div style="text-align: left;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">&#160;</font></div>
          </td>
          <td style="width: 88.08%; vertical-align: top; background-color: #FFFFFF;">
            <div style="text-align: left;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">AngioDynamics, Inc. 2004 Stock and Incentive Award Plan, as amended.*****</font></div>
          </td>
        </tr>
        <tr>
          <td style="width: 10.25%; vertical-align: top; background-color: #FFFFFF;">
            <div style="text-align: left;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">10.2</font></div>
          </td>
          <td style="width: 1.68%; vertical-align: top; background-color: #FFFFFF;">
            <div style="text-align: left;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">&#160;</font></div>
          </td>
          <td style="width: 88.08%; vertical-align: top; background-color: #FFFFFF;">
            <div style="text-align: left;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">AngioDynamics, Inc. Employee Stock Purchase Plan, as amended.******</font></div>
          </td>
        </tr>
        <tr>
          <td style="width: 10.25%; vertical-align: top; background-color: #FFFFFF;">
            <div style="text-align: left;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">23.1</font></div>
          </td>
          <td style="width: 1.68%; vertical-align: top; background-color: #FFFFFF;">
            <div style="text-align: left;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">&#160;</font></div>
          </td>
          <td style="width: 88.08%; vertical-align: top; background-color: #FFFFFF;">
            <div style="text-align: left;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">Consent of Stephen A. Trowbridge, Esq., Senior Vice President and General Counsel of the Registrant (included in Exhibit 5.1).+</font></div>
          </td>
        </tr>
        <tr>
          <td style="width: 10.25%; vertical-align: top; background-color: #FFFFFF;">
            <div style="text-align: left;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">23.2</font></div>
          </td>
          <td style="width: 1.68%; vertical-align: top; background-color: #FFFFFF;">
            <div style="text-align: left;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">&#160;</font></div>
          </td>
          <td style="width: 88.08%; vertical-align: top; background-color: #FFFFFF;">
            <div style="text-align: left;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">Consent of Deloitte &amp; Touche LLP.+</font></div>
          </td>
        </tr>
        <tr>
          <td style="width: 10.25%; vertical-align: top; background-color: #FFFFFF;" rowspan="1">23.3<br>
          </td>
          <td style="width: 1.68%; vertical-align: top; background-color: #FFFFFF;" rowspan="1">&#160;</td>
          <td style="width: 88.08%; vertical-align: top; background-color: #FFFFFF;" rowspan="1">Consent of PricewaterhouseCoopers LLP.+<br>
          </td>
        </tr>
        <tr>
          <td style="width: 10.25%; vertical-align: top; background-color: #FFFFFF;">
            <div style="text-align: left;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">24.1</font></div>
          </td>
          <td style="width: 1.68%; vertical-align: top; background-color: #FFFFFF;">
            <div style="text-align: left;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">&#160;</font></div>
          </td>
          <td style="width: 88.08%; vertical-align: top; background-color: #FFFFFF;">
            <div style="text-align: left;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">Power of Attorney (included on signature page to this Registration Statement).+</font></div>
          </td>
        </tr>

    </table>
    <div style="text-align: justify;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">&#160;</font></div>
    <div>
      <hr noshade="noshade" align="left" style="height: 1px; width: 25%; color: #000000; background-color: #000000; text-align: left; margin-left: 0px; margin-right: auto; border: none;"></div>
    <table cellspacing="0" cellpadding="0" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%;" id="z0d254d995b8b4ccd9f2cc3a2ee959c9f">

        <tr>
          <td style="width: 6.33%; vertical-align: top; background-color: #FFFFFF;">
            <div style="text-align: justify;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">*</font></div>
          </td>
          <td style="width: 93.67%; vertical-align: top; background-color: #FFFFFF;">
            <div style="text-align: justify;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">Incorporated by reference to Exhibit 3.1 to the Registrant&#8217;s Quarterly Report on Form 10-Q filed with the SEC on October 7, 2005.</font></div>
          </td>
        </tr>
        <tr>
          <td style="width: 6.33%; vertical-align: top; background-color: #FFFFFF;">
            <div style="text-align: justify;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">**</font></div>
          </td>
          <td style="width: 93.67%; vertical-align: top; background-color: #FFFFFF;">
            <div style="text-align: justify;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">Incorporated by reference to Exhibit 3.1.2 to the Registrant&#8217;s Annual Report on Form 10-K filed with the SEC on August 10, 2015.</font></div>
          </td>
        </tr>
        <tr>
          <td style="width: 6.33%; vertical-align: top; background-color: #FFFFFF;">
            <div style="text-align: justify;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">***</font></div>
          </td>
          <td style="width: 93.67%; vertical-align: top; background-color: #FFFFFF;">
            <div style="text-align: justify;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">Incorporated by reference to Exhibit 3.1 to the Registrant&#8217;s Current Report on Form 8-K filed with the SEC on October 21, 2015.</font></div>
          </td>
        </tr>
        <tr>
          <td style="width: 6.33%; vertical-align: top; background-color: #FFFFFF;">
            <div style="text-align: justify;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">****</font></div>
          </td>
          <td style="width: 93.67%; vertical-align: top; background-color: #FFFFFF;">
            <div style="text-align: justify;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">Incorporated by reference to Exhibit 4.2 to Amendment No. 2 to the Registrant&#8217;s Registration Statement on Form S-1 filed with the SEC
                on May 5, 2004.</font></div>
          </td>
        </tr>
        <tr>
          <td style="width: 6.33%; vertical-align: top; background-color: #FFFFFF;">
            <div style="text-align: justify;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">*****</font></div>
          </td>
          <td style="width: 93.67%; vertical-align: top; background-color: #FFFFFF;">
            <div style="text-align: justify;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">Incorporated by reference to Appendix A to the Registrant&#8217;s Definitive Proxy Statement on Schedule 14A filed with the SEC on August
                30, 2018.</font></div>
          </td>
        </tr>
        <tr>
          <td style="width: 6.33%; vertical-align: top; background-color: #FFFFFF;">
            <div style="text-align: justify;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">******</font></div>
          </td>
          <td style="width: 93.67%; vertical-align: top; background-color: #FFFFFF;">
            <div style="text-align: justify;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">Incorporated by reference to Appendix B to the Registrant&#8217;s Definitive Proxy Statement on Schedule 14A filed with the SEC on August
                30, 2018.</font></div>
          </td>
        </tr>
        <tr>
          <td style="width: 6.33%; vertical-align: top; background-color: #FFFFFF;">
            <div style="text-align: justify;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif; font-weight: bold;">+</font></div>
          </td>
          <td style="width: 93.67%; vertical-align: top; background-color: #FFFFFF;">
            <div style="text-align: justify;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">Filed herewith.</font></div>
          </td>
        </tr>

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As filed with the Securities and Exchange Commission on February 22, 2019
Registration No. 333-_____
UNITED STATES
SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM S-8
REGISTRATION STATEMENT
UNDER THE SECURITIES ACT OF 1933
AngioDynamics, Inc.
(Exact Name of Registrant as Specified in Its Charter)
Delaware
11-3146460
(State or Other Jurisdiction of Incorporation or Organization)
(I.R.S. Employer Identification No.)
14 Plaza Drive
Latham, New York 12110
(Address of Principal Executive Offices) (Zip Code)
AngioDynamics, Inc. 2004 Stock and Incentive Award Plan (as amended)
AngioDynamics, Inc. Employee Stock Purchase Plan (as amended)
(Full Title of the Plan)
Stephen A. Trowbridge, Esq.
Senior Vice President and General Counsel
AngioDynamics, Inc.
14 Plaza Drive
Latham, New York 12110
(518) 795-1400
(Name, Address and Telephone Number,
including Area Code, of Agent for Service)
Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, a smaller reporting
        company or an emerging growth company. See the definitions of "large accelerated filer," "accelerated filer," "smaller reporting company," and "emerging growth company" in Rule 12b-2 of the Exchange Act.
Large accelerated filer
☐
Accelerated filer
☒
Non-accelerated filer
☐
Smaller reporting company
☐
Emerging growth company
☐
If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition
        period for complying with any new or revised financial accounting standards provided pursuant to Section 7(a)(2)(B) of the Securities Act.
☐
CALCULATION OF REGISTRATION FEE
Title of Securities
to be Registered
Amount to be
Registered(1)
Proposed Maximum Offering
Price Per Share(2)
Proposed Maximum
Aggregate Offering Price(2)
Amount of
Registration Fee(2)
Common Stock, par value $0.01 per share
2,500,000 shares(3)
$23.32
$58,300,000
$7,065.96
(1)
Pursuant to Rule 416 under the Securities Act of 1933, as amended (the "Securities Act"), this Registration Statement also covers an
                indeterminate number of additional shares of common stock, par value $0.01 per share, of AngioDynamics, Inc. ("Common Stock") that may become issuable under the AngioDynamics, Inc. 2004 Stock and Incentive Award Plan, as amended, and the
                AngioDynamics, Inc. Employee Stock Purchase Plan, as amended, by reason of any stock dividend, stock split, recapitalization or any other similar transaction.
(2)
Pursuant to Rule 457 under the Securities Act, the proposed maximum aggregate offering price and the registration fee are estimated
                based upon the average of the high and low sale prices of the Common Stock as reported on The Nasdaq Global Select Market on Febrary 15
, 2019.
(3)
This number consists of (i) 1,000,000 shares of Common Stock available for issuance under the AngioDynamics, Inc. 2004 Stock and
                Incentive Award Plan, as amended, and (ii) 1,500,000 shares of Common Stock available for issuance under the AngioDynamics, Inc. Employee Stock Purchase Plan, as amended.
EXPLANATORY NOTE
This Registration Statement on Form S-8 (this "Registration Statement") is filed with the Securities and Exchange
        Commission (the "SEC") by AngioDynamics, Inc., a Delaware corporation (the "Registrant"), in order to register (i) an additional 1,000,000 shares of the Registrant's common stock, par value $0.01 per share ("Common Stock"), available for issuance
        under the AngioDynamics, Inc. 2004 Stock and Incentive Award Plan, as amended (the "2004 Plan"), and (ii) an additional 1,500,000 shares of Common Stock available for issuance under the AngioDynamics, Inc. Employee Stock Purchase Plan, as amended
        (the "Purchase Plan" and, together with the 2004 Plan, the "Plans").
On October 28, 2004, the Registrant filed with the SEC a Registration Statement on Form S-8 (File No. 333-120057) to
        register 1,000,000 shares of Common Stock issuable under the 2004 Plan and 200,000 shares of Common Stock issuable under the Purchase Plan (the "2004 Registration Statement"). On November 6, 2006, the Registrant filed with the SEC a Registration
        Statement on Form S-8 (File No. 333-138456) to register an additional 1,000,000 shares of Common Stock issuable under the 2004 Plan (the "2006 Registration Statement"). On August 14, 2009, the Registrant filed with the SEC a Registration Statement
        on Form S-8 (File No. 333-161355) to register an additional 1,000,000 shares of Common Stock issuable under the 2004 Plan and an additional 200,000 shares of Common Stock issuable under the Purchase Plan (the "August 2009 Registration Statement").
        On November 3, 2009, the Registrant filed with the SEC a Registration Statement on Form S-8 (File No. 333-162844) to register an additional 750,000 shares of Common Stock issuable under the 2004 Plan (the "November 2009 Registration Statement"). On
        November 16, 2010, the Registrant filed with the SEC a Registration Statement on Form S-8 (File No. 333-170619) to register an additional 300,000 shares of Common Stock issuable under the Purchase Plan (the "2010 Registration Statement"). On August
        15, 2013, the Registrant filed with the SEC a Registration Statement on Form S-8 (File No. 333-190640) to register an additional 2,000,000 shares of Common Stock issuable under the 2004 Plan and an additional 500,000 shares of Common Stock issuable
        under the Purchase Plan (the "2013 Registration Statement"). On April 16, 2015, the Registrant filed with the SEC a Registration Statement on Form S-8 (File No. 333-203441) to register an additional 1,000,000 shares of Common Stock issuable under
        the 2004 Plan and an additional 800,000 shares of Common Stock issuable under the Purchase Plan (the "2015 Registration Statement").
On October 25, 2016, the stockholders of the Registrant approved (i) an amendment to the 2004 Plan to increase the number
        of shares of Common Stock issuable under the 2004 Plan from 6,750,000 to 7,000,000 shares and (ii) an amendment to the Purchase Plan to increase the number of shares of Common Stock issuable under the Purchase Plan from 2,000,000 to 2,500,000
        shares (collectively, the "2016 Share Increases"). On October 10, 2018, the stockholders of the Registrant approved (i) an amendment to the 2004 Plan to increase the number of shares of Common Stock issuable under the 2004 Plan from 7,000,000 to
        7,750,000 shares and (ii) an amendment to the Purchase Plan to increase the number of shares of Common Stock issuable under the Purchase Plan from 2,500,000 to 3,500,000 shares (collectively, the "2018 Share Increases"). This Registration Statement
        is being filed to register the additional 1,000,000 shares of Common Stock issuable under the 2004 Plan and the additional 1,500,000 shares of Common Stock issuable under the Purchase Plan as approved by the stockholders of the Registrant pursuant
        to the 2016 Share Increases and the 2018 Share Increases.
Pursuant to General Instruction E to Form S-8, this Registration Statement incorporates by reference the contents of the
        2004 Registration Statement, the 2006 Registration Statement, the August 2009 Registration Statement, the November 2009 Registration Statement, the 2010 Registration Statement, the 2013 Registration Statement and the 2015 Registration Statement,
        including, with respect to each registration statement, each of the documents filed by the Registrant with the SEC and incorporated or deemed to be incorporated by reference therein and including each of the documents filed as exhibits to such
        registration statement, except as otherwise updated or modified in this Registration Statement.
PART II
INFORMATION REQUIRED IN THE REGISTRATION STATEMENT
Item 3.
Incorporation of Documents by Reference.
The following documents filed by the Registrant with the SEC pursuant to Section 13 of the Securities Exchange Act of
        1934, as amended (the "Exchange Act") (File No. 000-50761), are incorporated herein by reference: (i) the Annual Report on Form 10-K (including the portions of the Registrant's Proxy Statement incorporated by reference therein) for the fiscal year
        ended May 31, 2018, filed with the SEC on July 23, 2018; (ii) the Quarterly Reports on Form 10-Q for the fiscal periods ended August 31, 2018 and November 30, 2018, filed with the SEC on October 1, 2018 and January 7, 2019, respectively; (iii) the
        Current Report on Form 8-K filed with the SEC on October 12, 2018; and (iv) the description of the Common Stock contained in the Registrant's registration statement on Form 8-A (Registration No. 000-50761), filed by the Registrant with the SEC
        under Section 12(b) of the Exchange Act on May 13, 2004, including any amendments or reports filed for the purpose of updating such description. All documents filed by the Registrant pursuant to Sections 13(a), 13(c), 14 or 15(d) of the Exchange
        Act subsequent to the date of this Registration Statement and prior to the filing of a post-effective amendment indicating that all securities offered hereby have been sold or deregistering all securities then remaining unsold, shall be deemed to
        be incorporated by reference into this Registration Statement and to be a part hereof from the date of filing of such documents.
Item 5.
Interests of Named Experts and Counsel.
Stephen A. Trowbridge, who is providing an opinion on the validity of the issuance of the shares of Common Stock being
        registered hereby, is Senior Vice President and General Counsel of the Registrant. As an employee of the Registrant, Mr. Trowbridge participates in equity compensation plans of the Registrant on the same basis as other similarly eligible employees,
        pursuant to which Mr. Trowbridge owns or has options or rights to acquire an aggregate of less than 1% of the Registrant's outstanding Common Stock. Mr. Trowbridge is eligible to participate in the Plans.
Item 8.
Exhibits.
EXHIBIT NUMBER
DESCRIPTION
3.1.1
Amended and Restated Certificate of Incorporation
                  of the Registrant.*
3.1.2
Certificate of Amendment to the Amended and
                  Restated Certificate of Incorporation of the Registrant.**
3.2
Second Amended and Restated Bylaws of
                  the Registrant, effective October 16, 2015.***
4.2
Form of Specimen Certificate for the Registrant's
                  Common Stock.****
5.1
Opinion of
                  Stephen A. Trowbridge, Senior Vice President and General Counsel of the Registrant.+
10.1
AngioDynamics, Inc. 2004 Stock and
                  Incentive Award Plan, as amended.*****
10.2
AngioDynamics, Inc. Employee Stock
                  Purchase Plan, as amended.******
23.1
Consent of
                  Stephen A. Trowbridge, Esq., Senior Vice President and General Counsel of the Registrant (included in Exhibit 5.1).+
23.2
Consent of
                  Deloitte & Touche LLP.+
23.3
Consent of PricewaterhouseCoopers
              LLP.+
24.1
Power of Attorney (included on signature page to this Registration Statement).+
*
Incorporated by reference to Exhibit 3.1 to the Registrant's Quarterly Report on Form 10-Q filed with the SEC on October 7, 2005.
**
Incorporated by reference to Exhibit 3.1.2 to the Registrant's Annual Report on Form 10-K filed with the SEC on August 10, 2015.
***
Incorporated by reference to Exhibit 3.1 to the Registrant's Current Report on Form 8-K filed with the SEC on October 21, 2015.
****
Incorporated by reference to Exhibit 4.2 to Amendment No. 2 to the Registrant's Registration Statement on Form S-1 filed with the SEC
                on May 5, 2004.
*****
Incorporated by reference to Appendix A to the Registrant's Definitive Proxy Statement on Schedule 14A filed with the SEC on August
                30, 2018.
******
Incorporated by reference to Appendix B to the Registrant's Definitive Proxy Statement on Schedule 14A filed with the SEC on August
                30, 2018.
+
Filed herewith.
SIGNATURES
Pursuant to the requirements of the Securities Act of 1933, the Registrant certifies that it has reasonable grounds to
        believe that it meets all of the requirements for filing on Form S-8 and has duly caused this Registration Statement to be signed on its behalf by the undersigned, thereunto duly authorized, in the City of Latham, State of New York, on February 22
, 2019.
ANGIODYNAMICS, INC.
By:
/s/ James C. Clemmer
Name: James C. Clemmer
Title: President and Chief Executive Officer
KNOW ALL MEN BY THESE PRESENTS, that each person whose signature appears below constitutes and appoints James C. Clemmer
        and Michael C. Greiner, and each or either of them, as his true and lawful attorneys-in-fact and agents, with full power of substitution and resubstitution, for each of them and in each of their names, place and stead, in any and all capacities, to
        sign any and all amendments (including post-effective amendments) to this Registration Statement, and to file the same, with all exhibits thereto, and other documents in connection therewith, with the Securities and Exchange Commission, granting
        unto said attorneys-in-fact and agents, and each or either of them, full power and authority to do and perform each and every act and thing requisite and necessary to be done, as fully to all intents and purposes as each of them might or could do
        in person, hereby ratifying and confirming all that said attorneys-in-fact and agents, and each or either of them, or his substitute or substitutes, may lawfully do or cause to be done by virtue hereof.
Pursuant to the requirements of the Securities Act of 1933, this Registration Statement has been signed by the following
        persons in the capacities indicated on February 22
, 2019.
Signature
Title
/s/ Howard W. Donnelly
Chairman of the Board, Director
Howard W. Donnelly
/s/ James C. Clemmer
President and Chief Executive Officer and Director
James C. Clemmer
(Principal Executive Officer)
/s/ Michael C. Greiner
Executive Vice President and Chief Financial Officer
Michael C. Greiner
(Principal Financial Officer and
Principal Accounting Officer)
/s/ Eileen O. Auen
Director
Eileen Auen
/s/ Jeffrey G. Gold
Director
Jeffrey G. Gold
/s/ Kevin J. Gould
Director
Kevin J. Gould
/s/ Wesley E. Johnson, Jr.
Director
Wesley E. Johnson, Jr.
/s/ Dennis S. Meteny
Director
Dennis S. Meteny
/s/ Jan Stern Reed
Director
Jan Stern Reed
EXHIBIT INDEX
EXHIBIT NUMBER
DESCRIPTION
3.1.1
Amended and Restated Certificate of Incorporation of the Registrant.*
3.1.2
Certificate of Amendment to the Amended and Restated Certificate of Incorporation of the Registrant.**
3.2
Second Amended and Restated Bylaws of the Registrant, effective October 16, 2015.***
4.2
Form of Specimen Certificate for the Registrant's Common Stock.****
5.1
Opinion of Stephen A. Trowbridge, Senior Vice President and General Counsel of the Registrant.+
10.1
AngioDynamics, Inc. 2004 Stock and Incentive Award Plan, as amended.*****
10.2
AngioDynamics, Inc. Employee Stock Purchase Plan, as amended.******
23.1
Consent of Stephen A. Trowbridge, Esq., Senior Vice President and General Counsel of the Registrant (included in Exhibit 5.1).+
23.2
Consent of Deloitte & Touche LLP.+
23.3
Consent of PricewaterhouseCoopers LLP.+
24.1
Power of Attorney (included on signature page to this Registration Statement).+
*
Incorporated by reference to Exhibit 3.1 to the Registrant's Quarterly Report on Form 10-Q filed with the SEC on October 7, 2005.
**
Incorporated by reference to Exhibit 3.1.2 to the Registrant's Annual Report on Form 10-K filed with the SEC on August 10, 2015.
***
Incorporated by reference to Exhibit 3.1 to the Registrant's Current Report on Form 8-K filed with the SEC on October 21, 2015.
****
Incorporated by reference to Exhibit 4.2 to Amendment No. 2 to the Registrant's Registration Statement on Form S-1 filed with the SEC
                on May 5, 2004.
*****
Incorporated by reference to Appendix A to the Registrant's Definitive Proxy Statement on Schedule 14A filed with the SEC on August
                30, 2018.
******
Incorporated by reference to Appendix B to the Registrant's Definitive Proxy Statement on Schedule 14A filed with the SEC on August
                30, 2018.
+
Filed herewith.