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<P ALIGN="CENTER"><FONT SIZE=2><B>As filed with the Securities and Exchange Commission on April 18, 2001  </B></FONT></P>

<P ALIGN="RIGHT"><FONT SIZE=2><B> Registration No.&nbsp;333-&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</B></FONT></P>

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<P ALIGN="CENTER"><FONT SIZE=5><B>SECURITIES AND EXCHANGE COMMISSION<BR>  </B></FONT><FONT SIZE=2><B>Washington, D.C. 20549  </B></FONT></P>

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<P ALIGN="CENTER"><FONT SIZE=5><B>FORM S-8<BR>  </B></FONT><FONT SIZE=2><B>REGISTRATION STATEMENT<BR>
UNDER<BR>
THE SECURITIES ACT OF 1933  </B></FONT></P>

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<P ALIGN="CENTER"><FONT SIZE=5><B>AFFYMETRIX,&nbsp;INC.<BR>  </B></FONT><FONT SIZE=2>(Exact name of registrant as specified in its charter) </FONT></P>

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<TD WIDTH="50%" ALIGN="CENTER"><FONT SIZE=2><B>DELAWARE</B></FONT></TD>
<TD WIDTH="50%" ALIGN="CENTER"><FONT SIZE=2><B>77-0319159</B></FONT></TD>
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<TD WIDTH="50%" ALIGN="CENTER"><FONT SIZE=2>(State or other jurisdiction of</FONT></TD>
<TD WIDTH="50%" ALIGN="CENTER"><FONT SIZE=2>(IRS Employer Identification No.)</FONT></TD>
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<TD WIDTH="50%" ALIGN="CENTER"><FONT SIZE=2>incorporation or organization)</FONT></TD>
<TD WIDTH="50%"><FONT SIZE=2>&nbsp;</FONT></TD>
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<P ALIGN="CENTER"><FONT SIZE=2><B>3380 CENTRAL EXPRESSWAY<BR>
SANTA CLARA, CA 95051<BR>  </B></FONT><FONT SIZE=2>(Address of principal executive offices) (Zip Code) </FONT></P>

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<P ALIGN="CENTER"><FONT SIZE=2><B>AFFYMETRIX,&nbsp;INC. 2000 EQUITY INCENTIVE PLAN<BR>  </B></FONT><FONT SIZE=2>(Full title of the Plan) </FONT></P>

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<P ALIGN="CENTER"><FONT SIZE=2><B>VERN NORVIEL<BR>
SENIOR VICE PRESIDENT, GENERAL COUNSEL and CORPORATE SECRETARY<BR>
AFFYMETRIX,&nbsp;INC.<BR>
3380 CENTRAL EXPRESSWAY<BR>
SANTA CLARA, CA 95051<BR>  </B></FONT><FONT SIZE=2>(Name and address of agent for service) </FONT></P>

<P ALIGN="CENTER"><FONT SIZE=2><B>(408)&nbsp;731-5000<BR>  </B></FONT><FONT SIZE=2>(Telephone number, including area code, of agent for service) </FONT></P>

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<P ALIGN="CENTER"><FONT SIZE=2><B>CALCULATION OF REGISTRATION FEE  </B></FONT></P>

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<TD WIDTH="34%" ALIGN="CENTER" VALIGN="BOTTOM"><FONT SIZE=1><B>TITLE OF SECURITIES TO BE<BR>
REGISTERED (1)</B></FONT></TD>
<TD WIDTH="1%" VALIGN="BOTTOM"><FONT SIZE=1>&nbsp;</FONT></TD>
<TD WIDTH="14%" ALIGN="CENTER" VALIGN="BOTTOM"><FONT SIZE=1><B>AMOUNT TO BE REGISTERED (2)</B></FONT></TD>
<TD WIDTH="1%" VALIGN="BOTTOM"><FONT SIZE=1>&nbsp;</FONT></TD>
<TD WIDTH="14%" ALIGN="CENTER" VALIGN="BOTTOM"><FONT SIZE=1><B>PROPOSED MAXIMUM OFFERING PRICE PER SHARE (3)</B></FONT></TD>
<TD WIDTH="1%" VALIGN="BOTTOM"><FONT SIZE=1>&nbsp;</FONT></TD>
<TD WIDTH="19%" ALIGN="CENTER" VALIGN="BOTTOM"><FONT SIZE=1><B>PROPOSED MAXIMUM AGGREGATE OFFERING<BR>
PRICE (3)</B></FONT></TD>
<TD WIDTH="1%" VALIGN="BOTTOM"><FONT SIZE=1>&nbsp;</FONT></TD>
<TD WIDTH="16%" ALIGN="CENTER" VALIGN="BOTTOM"><FONT SIZE=1><B>AMOUNT OF REGISTRATION<BR>
FEE (3)</B></FONT></TD>
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<TD WIDTH="34%"><FONT SIZE=2>Common Stock (par value $.01)</FONT></TD>
<TD WIDTH="1%"><FONT SIZE=2>&nbsp;</FONT></TD>
<TD WIDTH="14%" ALIGN="CENTER"><FONT SIZE=2>5,000,000</FONT></TD>
<TD WIDTH="1%"><FONT SIZE=2>&nbsp;</FONT></TD>
<TD WIDTH="14%" ALIGN="CENTER"><FONT SIZE=2>$39.28</FONT></TD>
<TD WIDTH="1%"><FONT SIZE=2>&nbsp;</FONT></TD>
<TD WIDTH="19%" ALIGN="CENTER"><FONT SIZE=2>$196,399,553.81</FONT></TD>
<TD WIDTH="1%"><FONT SIZE=2>&nbsp;</FONT></TD>
<TD WIDTH="16%" ALIGN="CENTER"><FONT SIZE=2>$49,098.89</FONT></TD>
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<TD WIDTH="4%"><FONT SIZE=2>(1)</FONT></TD>
<TD WIDTH="2%"><FONT SIZE=2>&nbsp;</FONT></TD>
<TD WIDTH="94%"><FONT SIZE=2>This Registration Statement covers shares of Common Stock of Affymetrix,&nbsp;Inc. which may be offered or sold pursuant to the Affymetrix,&nbsp;Inc. 2000 Equity Incentive Plan (the "Plan"). This Registration Statement
shall also cover any additional shares of Common Stock which become issuable under the Plan by reason of any stock dividend, stock split, recapitalization or other similar transaction effected without the receipt of consideration which results in an
increase in the number of the outstanding shares of Common Stock of Affymetrix,&nbsp;Inc. This Registration Statement also relates to the Rights to purchase shares of Series&nbsp;B Junior Participating Stock of Affymetrix,&nbsp;Inc. which are
attached to all shares of Common Stock outstanding as of, and issued subsequent to, October&nbsp;15, 1998, pursuant to Affymetrix,&nbsp;Inc.'s Rights Agreement dated as of October&nbsp;15, 1998, as amended. Until the occurrence of certain prescribed
events, the Rights are not exercisable, are evidenced by the certificates for the Common Stock, and will be transferred with and only with such stock.</FONT></TD>
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(2)</FONT></TD>
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As adopted by the Board of Directors of the Registrant effective March&nbsp;9, 2000 and approved by the stockholders on June&nbsp;8, 2000, the Plan authorizes issuance of 2,500,000 shares, or 5,000,000 shares as adjusted for the 2 for 1 stock split
effective August&nbsp;21, 2000.</FONT></TD>
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(3)</FONT></TD>
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Calculated solely for purposes of this offering under Rules&nbsp;457(c) and 457(h) of the Securities Act of 1933, as amended, based upon the sum of (a)&nbsp;the aggregate offering price with respect to 2,210,800 stock options for which the exercise
price is known, and (b)&nbsp;2,789,200 stock options for which the exercise price is not known multiplied by the the average of the high and low prices of the Registrant's Common Stock reported on the Nasdaq National Market on April&nbsp;11,
2001.<BR>
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<BR></FONT><FONT SIZE=2><B>PART I<BR>  <BR>    INFORMATION REQUIRED IN SECTION 10(a) PROSPECTUS    <BR>  </B></FONT></P>

<P><FONT SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;The information required in Part&nbsp;I of Form&nbsp;S-8 to be contained in a prospectus meeting the requirements of Section&nbsp;10(a) of
the Securities Act of 1933, as amended (the "Securities Act"), is not required to be filed with the Securities and Exchange Commission and is omitted from this Registration Statement in accordance
with the explanatory note to Part&nbsp;I of Form&nbsp;S-8 and Rule&nbsp;428 and under the Securities Act. </FONT></P>

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<BR></FONT><FONT SIZE=2><B>PART II<BR>  <BR>    INFORMATION REQUIRED IN THE REGISTRATION STATEMENT    <BR>  </B></FONT></P>

<P><FONT SIZE=2><B>Item 3. INCORPORATION OF DOCUMENTS BY REFERENCE  </B></FONT></P>

<P><FONT SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;Affymetrix,&nbsp;Inc. (the "Registrant") hereby incorporates by reference into this Registration Statement the following documents previously filed with the
Securities and Exchange Commission (the "SEC"): </FONT></P>

<UL>
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<DT><FONT SIZE=2>&#149;</FONT></DT><DD><FONT SIZE=2>Annual
Report on Form&nbsp;10-K for the year ended December&nbsp;31, 2000;
<BR><BR></FONT></DD><DT><FONT SIZE=2>&#149;</FONT></DT><DD><FONT SIZE=2>Current
Reports on Form&nbsp;8-K filed on January&nbsp;12, 2001, March&nbsp;7, 2001, March&nbsp;26, 2001, and April&nbsp;3, 2001.
<BR><BR></FONT></DD><DT><FONT SIZE=2>&#149;</FONT></DT><DD><FONT SIZE=2>Amendment&nbsp;No.
1 to Current Report on Form 8-K/A filed on January&nbsp;12, 2001 amending Current Report on Form 8-K filed on November&nbsp;13,
2000.
<BR><BR></FONT></DD><DT><FONT SIZE=2>&#149;</FONT></DT><DD><FONT SIZE=2>Form&nbsp;8-A
filed on October&nbsp;16, 1998, as amended by Form&nbsp;8-A/A filed on March&nbsp;29, 2000; and
<BR><BR></FONT></DD><DT><FONT SIZE=2>&#149;</FONT></DT><DD><FONT SIZE=2>Registration
Statement No.&nbsp;0-28218 on Form&nbsp;8-A filed with the SEC on April&nbsp;16, 1996 pursuant to
Section&nbsp;12 of the Securities Exchange Act of 1934, as amended, with amendments thereto, in which there is described the terms, rights and provisions applicable to the Registrant's Common Stock. </FONT></DD></DL>
</UL>

<P><FONT SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;All
reports and definitive proxy or information statements filed pursuant to Section&nbsp;13(a), 13(c), 14 or 15(d) of the 1934 Act after the date of this Registration Statement and
prior to the filing of a post-effective amendment which indicates that all securities offered hereby have been sold or which deregisters all securities then remaining unsold shall be
deemed to be incorporated by reference into this Registration Statement and to be a part hereof from the date of filing of such documents. </FONT></P>

<P><FONT SIZE=2><B>Item 4. DESCRIPTION OF SECURITIES  </B></FONT></P>

<P><FONT SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;Not Applicable. </FONT></P>

<P><FONT SIZE=2><B>Item 5. INTERESTS OF NAMED EXPERTS AND COUNSEL  </B></FONT></P>

<P><FONT SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;The legality of the shares of Common Stock offered hereby has been passed upon for the Registrant by Vern Norviel, Esq. Mr.&nbsp;Norviel is Senior Vice
President, General Counsel and Corporate Secretary of Affymetrix,&nbsp;Inc. </FONT></P>


<P><FONT SIZE=2><B>Item 6. INDEMNIFICATION OF DIRECTORS AND OFFICERS  </B></FONT></P>

<P><FONT SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;Section&nbsp;145 of the Delaware General Corporation law empowers a Delaware corporation to indemnify any person who is, or is threatened to be made, a party
to any threatened, pending or completed legal action, suit or proceedings, whether civil, criminal, administrative or investigative (other </FONT></P>

<P ALIGN="CENTER"><FONT SIZE=2>2</FONT></P>

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than by or in the right of such corporation), by reason of the fact that such person is or was an officer or director of such corporation, or is or was serving at the request of such corporation as a
director,
officer, employee or agent of another corporation or enterprise. The indemnity may include expenses (including attorneys' fees), judgements, fines and amounts paid in settlement actually and
reasonably incurred by such person in connection with such action, suit or proceeding, provided that such person acted in good faith and in a manner he or she reasonably believed to be in or not
opposed to the corporation's best interests, and, for criminal proceedings, had no reasonable cause to believe his or her conduct was illegal. A Delaware corporation may indemnify officers and
directors in an action by or in the right of the corporation under the same conditions, except that no indemnification is permitted without judicial approval if the officer or director is adjudged to
be liable to the corporation in the performance of his duty. Where an officer or director is successful on the merits or otherwise in the defense of any action referred to above, the corporation must
indemnify him or her against the expenses which such officer or director actually and reasonably incurred. </FONT></P>

<P><FONT SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;In
accordance with Delaware law, Registrant's restated certificate of incorporation contains a provision to limit the personal liability of Registrant's directors for violations of
their fiduciary duty as a director. This provision eliminates each director's liability to Registrant or Registrant's stockholders for monetary damages except (i)&nbsp;for any breach of the
director's duty of loyalty to Registrant or Registrant's stockholders, (ii)&nbsp;for acts or omissions not in good faith or which involve intentional misconduct or a knowing violation of law,
(iii)&nbsp;under Section&nbsp;174 of the Delaware General Corporation law providing for liability of directors for unlawful payment of dividends or unlawful stock purchases or redemptions, or
(iv)&nbsp;for any transaction from which a director derived an improper personal benefit. The effect of this provision is to eliminate the personal liability of directors for monetary damages for
actions involving a breach of their fiduciary duty of care, including any such actions involving gross negligence. </FONT></P>

<P><FONT SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;Registrant's
restated certificate of incorporation and bylaws provide for indemnification of its officers and directors to the fullest extent permitted by applicable law. </FONT></P>


<P><FONT SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;Registrant
has entered into indemnification agreements with each director and executive officer which provide indemnification to such directors and executive officers under certain
circumstances for acts or omissions which may not be covered by directors' and officers' liability insurance. </FONT></P>

<P><FONT SIZE=2><B>Item 7. EXEMPTION FROM REGISTRATION CLAIMED  </B></FONT></P>

<P><FONT SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;Not Applicable. </FONT></P>

<P ALIGN="CENTER"><FONT SIZE=2>3</FONT></P>

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<P><FONT SIZE=2><B>Item 8. EXHIBITS  </B></FONT></P>

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<TH WIDTH="10%" ALIGN="LEFT"><FONT SIZE=1><B>Exhibit Number<BR> </B></FONT><HR NOSHADE></TH>
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<TH WIDTH="88%" ALIGN="LEFT"><FONT SIZE=1><B>Exhibit<BR> </B></FONT><HR NOSHADE></TH>
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(1)4.1</FONT></TD>
<TD WIDTH="2%"><FONT SIZE=2><BR>&nbsp;</FONT></TD>
<TD WIDTH="88%"><FONT SIZE=2><BR>
Restated Certificate of Incorporation of Affymetrix, Inc.</FONT></TD>
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(2)4.2</FONT></TD>
<TD WIDTH="2%"><FONT SIZE=2><BR>&nbsp;</FONT></TD>
<TD WIDTH="88%"><FONT SIZE=2><BR>
Bylaws of Affymetrix, Inc.</FONT></TD>
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(3)4.3</FONT></TD>
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Rights Agreement, dated as of October 15, 1998, between Affymetrix, Inc. and American Stock Transfer &amp; Trust Company, as Rights Agent</FONT></TD>
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(4)4.4</FONT></TD>
<TD WIDTH="2%"><FONT SIZE=2><BR>&nbsp;</FONT></TD>
<TD WIDTH="88%"><FONT SIZE=2><BR>
Amendment No. 1 to Rights Agreement, dated as of February 7, 2000, between Affymetrix, Inc. and American Stock Transfer &amp; Trust Company, as Rights Agent</FONT></TD>
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<TD WIDTH="10%"><FONT SIZE=2><BR>
5.1</FONT></TD>
<TD WIDTH="2%"><FONT SIZE=2><BR>&nbsp;</FONT></TD>
<TD WIDTH="88%"><FONT SIZE=2><BR>
Opinion of Vern Norviel, Esq., Senior Vice President, General Counsel, and Corporate Secretary</FONT></TD>
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<TD WIDTH="10%"><FONT SIZE=2><BR>
23.1</FONT></TD>
<TD WIDTH="2%"><FONT SIZE=2><BR>&nbsp;</FONT></TD>
<TD WIDTH="88%"><FONT SIZE=2><BR>
Consent of Ernst &amp; Young LLP, Independent Auditors</FONT></TD>
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<TD WIDTH="10%"><FONT SIZE=2><BR>
23.2</FONT></TD>
<TD WIDTH="2%"><FONT SIZE=2><BR>&nbsp;</FONT></TD>
<TD WIDTH="88%"><FONT SIZE=2><BR>
Consent of Vern Norviel, Esq. (included in Exhibit 5.1)</FONT></TD>
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<TD WIDTH="10%"><FONT SIZE=2><BR>
24.1</FONT></TD>
<TD WIDTH="2%"><FONT SIZE=2><BR>&nbsp;</FONT></TD>
<TD WIDTH="88%"><FONT SIZE=2><BR>
Power of Attorney (included on the signature page hereto)</FONT></TD>
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<TD WIDTH="10%"><FONT SIZE=2><BR>
99.1</FONT></TD>
<TD WIDTH="2%"><FONT SIZE=2><BR>&nbsp;</FONT></TD>
<TD WIDTH="88%"><FONT SIZE=2><BR>
Affymetrix, Inc. 2000 Equity Incentive Plan</FONT></TD>
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<DT><FONT SIZE=2>(1)</FONT></DT><DD><FONT SIZE=2>Incorporated
by reference to Exhibit&nbsp;3.1 to our Form&nbsp;8-K as filed on June&nbsp;13, 2000 (File No.&nbsp;000-28218).
<BR><BR></FONT></DD><DT><FONT SIZE=2>(2)</FONT></DT><DD><FONT SIZE=2>Incorporated
by reference to Appendix&nbsp;C to our definitive proxy statement on Schedule&nbsp;14A as filed on April&nbsp;29, 1998 (File No.&nbsp;00-28218).
<BR><BR></FONT></DD><DT><FONT SIZE=2>(3)</FONT></DT><DD><FONT SIZE=2>Incorporated
by reference to Exhibit&nbsp;1 of our Form&nbsp;8-A as filed on October&nbsp;16, 1998 (File No.&nbsp;000-28218).
<BR><BR></FONT></DD><DT><FONT SIZE=2>(4)</FONT></DT><DD><FONT SIZE=2>Incorporated
by reference to Exhibit&nbsp;4.1 of our Form&nbsp;8-A/A as filed on March&nbsp;29, 2000 (File No.&nbsp;000-28218). </FONT></DD></DL>

<P><FONT SIZE=2><B>Item 9. UNDERTAKINGS  </B></FONT></P>

<P><FONT SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;A.&nbsp;&nbsp;The
undersigned Registrant hereby undertakes: (1)&nbsp;to file, during any period in which offers or sales are being made, a post-effective amendment
to this Registration Statement (i)&nbsp;to include any prospectus required by Section&nbsp;10(a)(3) of the 1933 Act, (ii)&nbsp;to reflect in the prospectus any facts or events arising after the
effective date of this Registration Statement (or the most recent post-effective amendment thereof) which, individually or in the aggregate, represent a fundamental change in the
information set forth in this Registration Statement and (iii)&nbsp;to include any material information with respect to the plan of distribution not previously disclosed in this Registration
Statement or any material change to such information in this Registration Statement; provided, however, that clauses (1)(i)&nbsp;and (1)(ii)&nbsp;shall not apply if the information required to be
included in a post-effective amendment by those paragraphs is contained in periodic reports filed by the Registrant pursuant to Section&nbsp;13 or Section&nbsp;15(d) of the 1934 Act
that are incorporated by reference into this Registration Statement; (2)&nbsp;that for the purpose of determining any liability under the 1933 Act each such post-effective amendment
shall be deemed to be a new registration statement relating to the securities offered therein and the offering of such securities at that time shall be deemed to be the initial bona fide offering
thereof; and (3)&nbsp;to remove from registration by means of a post-effective amendment any </FONT></P>

<P ALIGN="CENTER"><FONT SIZE=2>4</FONT></P>

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of the securities being registered which remain unsold at the termination of the Affymetrix,&nbsp;Inc. 2000 Equity Incentive Plan. </FONT></P>


<P><FONT SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;B.&nbsp;&nbsp;The
undersigned Registrant hereby undertakes that, for purposes of determining any liability under the 1933 Act, each filing of the Registrant's annual report
pursuant to Section&nbsp;13(a) or Section&nbsp;15(d) of
the 1934 Act that is incorporated by reference into this Registration Statement shall be deemed to be a new registration statement relating to the securities offered therein, and the offering of such
securities at that time shall be deemed to be the initial bona fide offering thereof. </FONT></P>

<P><FONT SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;C.&nbsp;&nbsp;Insofar
as indemnification for liabilities arising under the 1933 Act may be permitted to directors, officers or controlling persons of the Registrant pursuant to
the indemnification provisions summarized in Item 6 or otherwise, the Registrant has been advised that, in the opinion of the SEC, such indemnification is against public policy as expressed in the
1933 Act, and is, therefore, unenforceable. In the event that a claim for indemnification against such liabilities (other than the payment by the Registrant of expenses incurred or paid by a director,
officer or controlling person of the Registrant in the successful defense of any action, suit or proceeding) is asserted by such director, officer or controlling person in connection with the
securities being registered, the Registrant will, unless in the opinion of its counsel the matter has been settled by controlling precedent, submit to a court of appropriate jurisdiction the question
whether such indemnification by it is against public policy as expressed in the 1933 Act and will be governed by the final adjudication of such issue. </FONT></P>

<P ALIGN="CENTER"><FONT SIZE=2>5</FONT></P>

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<BR></FONT><FONT SIZE=2><B>SIGNATURES    <BR>  </B></FONT></P>

<P><FONT SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;Pursuant
to the requirements of the Securities Act of 1933, as amended, the Registrant certifies that it has reasonable grounds to believe that it meets all of the requirements for
filing on Form&nbsp;S-8, and has duly caused this Registration Statement to be signed on its behalf by the undersigned, thereunto duly authorized, in the City of Santa Clara, State of
California on this 18th day of April, 2001. </FONT></P>

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<TD WIDTH="51%" COLSPAN=3><FONT SIZE=2>AFFYMETRIX,&nbsp;INC.<BR></FONT>
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<TD WIDTH="47%"><FONT SIZE=2><BR>
&nbsp;</FONT></TD>
<TD WIDTH="2%"><FONT SIZE=2><BR>&nbsp;</FONT></TD>
<TD WIDTH="5%"><FONT SIZE=2><BR>
By:</FONT></TD>
<TD WIDTH="1%"><FONT SIZE=2><BR>&nbsp;</FONT></TD>
<TD WIDTH="45%" ALIGN="CENTER"><FONT SIZE=2><BR>
/s/&nbsp;</FONT><FONT SIZE=2>VERN NORVIEL</FONT><FONT SIZE=2>&nbsp;&nbsp;&nbsp;</FONT></TD>
</TR>
<TR VALIGN="TOP">
<TD WIDTH="47%"><FONT SIZE=2>&nbsp;</FONT></TD>
<TD WIDTH="2%"><FONT SIZE=2>&nbsp;</FONT></TD>
<TD WIDTH="5%"><FONT SIZE=2>&nbsp;</FONT></TD>
<TD WIDTH="1%"><FONT SIZE=2>&nbsp;</FONT></TD>
<TD WIDTH="45%" ALIGN="CENTER"><HR NOSHADE><FONT SIZE=2> Vern Norviel<BR></FONT> <FONT SIZE=2><I>Senior Vice President, General<BR>
Counsel and Corporate Secretary</I></FONT></TD>
</TR>
</TABLE>
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<P ALIGN="CENTER"><FONT SIZE=2><A
NAME="jc1547_power_of_attorney"> </A>
<A NAME="toc_jc1547_2"> </A>
<BR></FONT><FONT SIZE=2><B>POWER OF ATTORNEY    <BR>  </B></FONT></P>

<P><FONT SIZE=2>KNOW
ALL PERSONS BY THESE PRESENTS: </FONT></P>

<P><FONT SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;That
the undersigned officers and directors of Affymetrix,&nbsp;Inc., a Delaware corporation, do hereby constitute and appoint Stephen P.A. Fodor and Vern Norviel, and either of
them, the lawful attorneys-in-fact and agents with full power and authority to do any and all acts and things and to execute any and all instruments which said attorneys and
agents, and either one of them, determine may be necessary or advisable or required to enable said corporation to comply with the Securities Act of 1933, as amended, and any rules or regulations or
requirements of the Securities and Exchange Commission in connection with this Registration Statement. Without limiting the generality of the
foregoing power and authority, the powers granted include the power and authority to sign the names of the undersigned officers and directors in the capacities indicated below to this Registration
Statement, to any and all amendments, both pre-effective and post-effective, and supplements to this Registration Statement, and to any and all instruments or documents filed
as part of or in conjunction with this Registration Statement or amendments or supplements thereof, and each of the undersigned hereby ratifies and confirms all that said attorneys and agents, or
either one of them, shall do or cause to be done by virtue hereof. This Power of Attorney may be signed in several counterparts. </FONT></P>

<P><FONT SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;IN
WITNESS WHEREOF, each of the undersigned has executed this Power of Attorney as of the date indicated. </FONT></P>

<P><FONT SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;Pursuant
to the requirements of the Securities Act of 1933, as amended, this Registration Statement has been signed below by the following persons in the capacities and on the dates
indicated. </FONT></P>

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<TR VALIGN="BOTTOM">
<TH WIDTH="45%" ALIGN="CENTER"><FONT SIZE=1><B>Signature</B></FONT><HR NOSHADE></TH>
<TH WIDTH="2%"><FONT SIZE=1>&nbsp;</FONT></TH>
<TH WIDTH="32%" ALIGN="CENTER"><FONT SIZE=1><B>Title</B></FONT><HR NOSHADE></TH>
<TH WIDTH="2%"><FONT SIZE=1>&nbsp;</FONT></TH>
<TH WIDTH="18%" ALIGN="CENTER"><FONT SIZE=1><B>Date</B></FONT><HR NOSHADE></TH>
</TR>
<TR VALIGN="BOTTOM">
<TD WIDTH="45%" ALIGN="CENTER" VALIGN="CENTER"><BR><FONT SIZE=2>&nbsp;</FONT></TD>
<TD WIDTH="2%" VALIGN="CENTER"><FONT SIZE=2><BR>&nbsp;</FONT></TD>
<TD WIDTH="32%" VALIGN="CENTER"><FONT SIZE=2><BR>
&nbsp;</FONT></TD>
<TD WIDTH="2%" VALIGN="CENTER"><FONT SIZE=2><BR>&nbsp;</FONT></TD>
<TD WIDTH="18%" VALIGN="CENTER"><FONT SIZE=2><BR>
&nbsp;</FONT></TD>
</TR>
<TR VALIGN="TOP">
<TD WIDTH="45%" ALIGN="CENTER" VALIGN="CENTER"><FONT SIZE=2>/s/&nbsp;</FONT><FONT SIZE=2>STEPHEN P.A. FODOR</FONT><FONT SIZE=2>&nbsp;&nbsp;&nbsp;</FONT><HR NOSHADE><FONT SIZE=2> Stephen P.A. Fodor, Ph.D.</FONT></TD>
<TD WIDTH="2%" VALIGN="CENTER"><FONT SIZE=2>&nbsp;</FONT></TD>
<TD WIDTH="32%" VALIGN="CENTER"><FONT SIZE=2>Chief Executive Officer and Chairman of the Board</FONT></TD>
<TD WIDTH="2%" VALIGN="CENTER"><FONT SIZE=2>&nbsp;</FONT></TD>
<TD WIDTH="18%" ALIGN="CENTER" VALIGN="CENTER"><FONT SIZE=2>April&nbsp;18, 2001</FONT></TD>
</TR>
<TR VALIGN="TOP">
<TD WIDTH="45%" ALIGN="CENTER" VALIGN="CENTER"><FONT SIZE=2><BR>
/s/&nbsp;</FONT><FONT SIZE=2>EDWARD M. HURWITZ</FONT><FONT SIZE=2>&nbsp;&nbsp;&nbsp;</FONT><HR NOSHADE><FONT SIZE=2> Edward M. Hurwitz</FONT></TD>
<TD WIDTH="2%" VALIGN="CENTER"><FONT SIZE=2><BR>&nbsp;</FONT></TD>
<TD WIDTH="32%" VALIGN="CENTER"><FONT SIZE=2><BR>
Senior Vice President and Chief Financial Officer (Principal Financial and Accounting Officer)</FONT></TD>
<TD WIDTH="2%" VALIGN="CENTER"><FONT SIZE=2><BR>&nbsp;</FONT></TD>
<TD WIDTH="18%" ALIGN="CENTER" VALIGN="CENTER"><FONT SIZE=2><BR>
April&nbsp;18, 2001</FONT></TD>
</TR>
<TR VALIGN="BOTTOM">
<TD WIDTH="45%" VALIGN="CENTER"><BR></TD>
<TD WIDTH="2%" VALIGN="CENTER"><FONT SIZE=2><BR>&nbsp;</FONT></TD>
<TD WIDTH="32%" VALIGN="CENTER"><FONT SIZE=2><BR>
&nbsp;</FONT></TD>
<TD WIDTH="2%" VALIGN="CENTER"><FONT SIZE=2><BR>&nbsp;</FONT></TD>
<TD WIDTH="18%" VALIGN="CENTER"><FONT SIZE=2><BR>
&nbsp;</FONT></TD>
</TR>
</TABLE>
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<P ALIGN="CENTER"><FONT SIZE=2>6</FONT></P>

<HR NOSHADE>
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<A NAME="page_jc1547_1_7"> </A>
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<TABLE WIDTH="100%" BORDER=0 CELLSPACING=0 CELLPADDING=0>
<TR VALIGN="TOP">
<TD WIDTH="45%" ALIGN="CENTER" VALIGN="CENTER"><FONT SIZE=2><BR>
/s/&nbsp;</FONT><FONT SIZE=2>JOHN D. DIEKMAN</FONT><FONT SIZE=2>&nbsp;&nbsp;&nbsp;</FONT><HR NOSHADE><FONT SIZE=2> John D. Diekman, Ph.D.</FONT></TD>
<TD WIDTH="2%" VALIGN="CENTER"><FONT SIZE=2><BR>&nbsp;</FONT></TD>
<TD WIDTH="32%" VALIGN="CENTER"><FONT SIZE=2><BR>
Director</FONT></TD>
<TD WIDTH="2%" VALIGN="CENTER"><FONT SIZE=2><BR>&nbsp;</FONT></TD>
<TD WIDTH="18%" ALIGN="CENTER" VALIGN="CENTER"><FONT SIZE=2><BR>
April&nbsp;18, 2001</FONT></TD>
</TR>
<TR VALIGN="TOP">
<TD WIDTH="45%" ALIGN="CENTER" VALIGN="CENTER"><FONT SIZE=2><BR>
/s/&nbsp;</FONT><FONT SIZE=2>PAUL BERG</FONT><FONT SIZE=2>&nbsp;&nbsp;&nbsp;</FONT><HR NOSHADE><FONT SIZE=2> Paul Berg, Ph.D.</FONT></TD>
<TD WIDTH="2%" VALIGN="CENTER"><FONT SIZE=2><BR>&nbsp;</FONT></TD>
<TD WIDTH="32%" VALIGN="CENTER"><FONT SIZE=2><BR>
Director</FONT></TD>
<TD WIDTH="2%" VALIGN="CENTER"><FONT SIZE=2><BR>&nbsp;</FONT></TD>
<TD WIDTH="18%" ALIGN="CENTER" VALIGN="CENTER"><FONT SIZE=2><BR>
April&nbsp;18, 2001</FONT></TD>
</TR>
<TR VALIGN="TOP">
<TD WIDTH="45%" ALIGN="CENTER" VALIGN="CENTER"><FONT SIZE=2><BR>
/s/&nbsp;</FONT><FONT SIZE=2>VERNON R. LOUCKS, JR.</FONT><FONT SIZE=2>&nbsp;&nbsp;&nbsp;</FONT><HR NOSHADE><FONT SIZE=2> Vernon R. Loucks, Jr.</FONT></TD>
<TD WIDTH="2%" VALIGN="CENTER"><FONT SIZE=2><BR>&nbsp;</FONT></TD>
<TD WIDTH="32%" VALIGN="CENTER"><FONT SIZE=2><BR>
Director</FONT></TD>
<TD WIDTH="2%" VALIGN="CENTER"><FONT SIZE=2><BR>&nbsp;</FONT></TD>
<TD WIDTH="18%" ALIGN="CENTER" VALIGN="CENTER"><FONT SIZE=2><BR>
April&nbsp;18, 2001</FONT></TD>
</TR>
<TR VALIGN="TOP">
<TD WIDTH="45%" ALIGN="CENTER" VALIGN="CENTER"><FONT SIZE=2><BR>
/s/&nbsp;</FONT><FONT SIZE=2>DAVID B. SINGER</FONT><FONT SIZE=2>&nbsp;&nbsp;&nbsp;</FONT><HR NOSHADE><FONT SIZE=2> David B. Singer</FONT></TD>
<TD WIDTH="2%" VALIGN="CENTER"><FONT SIZE=2><BR>&nbsp;</FONT></TD>
<TD WIDTH="32%" VALIGN="CENTER"><FONT SIZE=2><BR>
Director</FONT></TD>
<TD WIDTH="2%" VALIGN="CENTER"><FONT SIZE=2><BR>&nbsp;</FONT></TD>
<TD WIDTH="18%" ALIGN="CENTER" VALIGN="CENTER"><FONT SIZE=2><BR>
April&nbsp;18, 2001</FONT></TD>
</TR>
<TR VALIGN="TOP">
<TD WIDTH="45%" ALIGN="CENTER" VALIGN="CENTER"><FONT SIZE=2><BR>
/s/&nbsp;</FONT><FONT SIZE=2>LUBERT STRYER</FONT><FONT SIZE=2>&nbsp;&nbsp;&nbsp;</FONT><HR NOSHADE><FONT SIZE=2> Lubert Stryer, M.D.</FONT></TD>
<TD WIDTH="2%" VALIGN="CENTER"><FONT SIZE=2><BR>&nbsp;</FONT></TD>
<TD WIDTH="32%" VALIGN="CENTER"><FONT SIZE=2><BR>
Director</FONT></TD>
<TD WIDTH="2%" VALIGN="CENTER"><FONT SIZE=2><BR>&nbsp;</FONT></TD>
<TD WIDTH="18%" ALIGN="CENTER" VALIGN="CENTER"><FONT SIZE=2><BR>
April&nbsp;18, 2001</FONT></TD>
</TR>
<TR VALIGN="TOP">
<TD WIDTH="45%" ALIGN="CENTER" VALIGN="CENTER"><FONT SIZE=2><BR>
/s/&nbsp;</FONT><FONT SIZE=2>JOHN A. YOUNG</FONT><FONT SIZE=2>&nbsp;&nbsp;&nbsp;</FONT><HR NOSHADE><FONT SIZE=2> John A. Young</FONT></TD>
<TD WIDTH="2%" VALIGN="CENTER"><FONT SIZE=2><BR>&nbsp;</FONT></TD>
<TD WIDTH="32%" VALIGN="CENTER"><FONT SIZE=2><BR>
Director</FONT></TD>
<TD WIDTH="2%" VALIGN="CENTER"><FONT SIZE=2><BR>&nbsp;</FONT></TD>
<TD WIDTH="18%" ALIGN="CENTER" VALIGN="CENTER"><FONT SIZE=2><BR>
April&nbsp;18, 2001</FONT></TD>
</TR>
</TABLE>
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<P ALIGN="CENTER"><FONT SIZE=2>7</FONT></P>

<HR NOSHADE>
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<P ALIGN="CENTER"><FONT SIZE=2><A
NAME="ka1547_exhibit_index"> </A>
<A NAME="toc_ka1547_1"> </A>
<BR></FONT><FONT SIZE=2><B>EXHIBIT INDEX    <BR>  </B></FONT></P>

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<TABLE WIDTH="100%" BORDER=0 CELLSPACING=0 CELLPADDING=0>
<TR VALIGN="BOTTOM">
<TH WIDTH="10%" ALIGN="CENTER"><FONT SIZE=1><B>Exhibit Number</B></FONT><HR NOSHADE></TH>
<TH WIDTH="2%"><FONT SIZE=1>&nbsp;</FONT></TH>
<TH WIDTH="88%" ALIGN="CENTER"><FONT SIZE=1><B>Exhibit</B></FONT><HR NOSHADE></TH>
</TR>
<TR BGCOLOR="#CCEEFF" VALIGN="TOP">
<TD WIDTH="10%"><FONT SIZE=2>(1)4.1</FONT></TD>
<TD WIDTH="2%"><FONT SIZE=2>&nbsp;</FONT></TD>
<TD WIDTH="88%"><FONT SIZE=2>Restated Certificate of Incorporation of Affymetrix, Inc.</FONT></TD>
</TR>
<TR BGCOLOR="White" VALIGN="TOP">
<TD WIDTH="10%"><FONT SIZE=2>(2)4.2</FONT></TD>
<TD WIDTH="2%"><FONT SIZE=2>&nbsp;</FONT></TD>
<TD WIDTH="88%"><FONT SIZE=2>Bylaws of Affymetrix, Inc.</FONT></TD>
</TR>
<TR BGCOLOR="#CCEEFF" VALIGN="TOP">
<TD WIDTH="10%"><FONT SIZE=2>(3)4.3</FONT></TD>
<TD WIDTH="2%"><FONT SIZE=2>&nbsp;</FONT></TD>
<TD WIDTH="88%"><FONT SIZE=2>Rights Agreement, dated as of October 15, 1998, between Affymetrix, Inc. and American Stock Transfer &amp; Trust Company, as Rights Agent</FONT></TD>
</TR>
<TR BGCOLOR="White" VALIGN="TOP">
<TD WIDTH="10%"><FONT SIZE=2>(4)4.4</FONT></TD>
<TD WIDTH="2%"><FONT SIZE=2>&nbsp;</FONT></TD>
<TD WIDTH="88%"><FONT SIZE=2>Amendment No. 1 to Rights Agreement, dated as of February 7, 2000, between Affymetrix, Inc. and American Stock Transfer &amp; Trust Company, as Rights Agent</FONT></TD>
</TR>
<TR BGCOLOR="#CCEEFF" VALIGN="TOP">
<TD WIDTH="10%"><FONT SIZE=2>5.1</FONT></TD>
<TD WIDTH="2%"><FONT SIZE=2>&nbsp;</FONT></TD>
<TD WIDTH="88%"><FONT SIZE=2>Opinion of Vern Norviel, Esq., Senior Vice President, General Counsel, and Corporate Secretary</FONT></TD>
</TR>
<TR BGCOLOR="White" VALIGN="TOP">
<TD WIDTH="10%"><FONT SIZE=2>23.1</FONT></TD>
<TD WIDTH="2%"><FONT SIZE=2>&nbsp;</FONT></TD>
<TD WIDTH="88%"><FONT SIZE=2>Consent of Ernst &amp; Young LLP, Independent Auditors</FONT></TD>
</TR>
<TR BGCOLOR="#CCEEFF" VALIGN="TOP">
<TD WIDTH="10%"><FONT SIZE=2>23.2</FONT></TD>
<TD WIDTH="2%"><FONT SIZE=2>&nbsp;</FONT></TD>
<TD WIDTH="88%"><FONT SIZE=2>Consent of Vern Norviel, Esq. (included in Exhibit 5.1)</FONT></TD>
</TR>
<TR BGCOLOR="White" VALIGN="TOP">
<TD WIDTH="10%"><FONT SIZE=2>24.1</FONT></TD>
<TD WIDTH="2%"><FONT SIZE=2>&nbsp;</FONT></TD>
<TD WIDTH="88%"><FONT SIZE=2>Power of Attorney (included on the signature page hereto)</FONT></TD>
</TR>
<TR BGCOLOR="#CCEEFF" VALIGN="TOP">
<TD WIDTH="10%"><FONT SIZE=2>99.1</FONT></TD>
<TD WIDTH="2%"><FONT SIZE=2>&nbsp;</FONT></TD>
<TD WIDTH="88%"><FONT SIZE=2>Affymetrix, Inc. 2000 Equity Incentive Plan</FONT></TD>
</TR>
</TABLE>
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<HR NOSHADE ALIGN="LEFT" WIDTH="120">
<DL compact>
<DT><FONT SIZE=2>(1)</FONT></DT><DD><FONT SIZE=2>Incorporated
by reference to Exhibit&nbsp;3.1 to our Form&nbsp;8-K as filed on June&nbsp;13, 2000 (File No.&nbsp;000-28218).
<BR><BR></FONT></DD><DT><FONT SIZE=2>(2)</FONT></DT><DD><FONT SIZE=2>Incorporated
by reference to Appendix&nbsp;C to our definitive proxy statement on Schedule&nbsp;14A as filed on April&nbsp;29, 1998 (File No. 000-28218).
<BR><BR></FONT></DD><DT><FONT SIZE=2>(3)</FONT></DT><DD><FONT SIZE=2>Incorporated
by reference to Exhibit&nbsp;1 of our Form&nbsp;8-A as filed on October&nbsp;16, 1998 (File No.&nbsp;000-28218).
<BR><BR></FONT></DD><DT><FONT SIZE=2>(4)</FONT></DT><DD><FONT SIZE=2>Incorporated
by reference to Exhibit&nbsp;4.1 of our Form&nbsp;8-A/A as filed on March&nbsp;29, 2000 (File No.&nbsp;000-28218). </FONT></DD></DL>
<HR NOSHADE>
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<P><br><A NAME="01PAL1547_1">QuickLinks</A><br></P><!-- TOC_BEGIN -->
<FONT SIZE=2><A HREF="#toc_de1547_1">PART I INFORMATION REQUIRED IN SECTION 10(a) PROSPECTUS</A></FONT><BR>
<FONT SIZE=2><A HREF="#toc_de1547_2">PART II INFORMATION REQUIRED IN THE REGISTRATION STATEMENT</A></FONT><BR>
<!-- TOC_BEGIN -->
<FONT SIZE=2><A HREF="#toc_jc1547_1">SIGNATURES</A></FONT><BR>
<FONT SIZE=2><A HREF="#toc_jc1547_2">POWER OF ATTORNEY</A></FONT><BR>
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<FONT SIZE=2><A HREF="#toc_ka1547_1">EXHIBIT INDEX</A></FONT><BR>
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[{"type": "S-8", "sequence": "1", "filename": "a2044652zs-8.htm", "description": "S-8", "secsgml_size_bytes": 37819}]
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Prepared by MERRILL CORPORATION www.edgaradvantage.com
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As filed with the Securities and Exchange Commission on April 18, 2001
Registration No. 333-
SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM S-8
REGISTRATION STATEMENT
UNDER
THE SECURITIES ACT OF 1933
AFFYMETRIX, INC.
(Exact name of registrant as specified in its charter)
DELAWARE
77-0319159
(State or other jurisdiction of
(IRS Employer Identification No.)
incorporation or organization)
3380 CENTRAL EXPRESSWAY
SANTA CLARA, CA 95051
(Address of principal executive offices) (Zip Code)
AFFYMETRIX, INC. 2000 EQUITY INCENTIVE PLAN
(Full title of the Plan)
VERN NORVIEL
SENIOR VICE PRESIDENT, GENERAL COUNSEL and CORPORATE SECRETARY
AFFYMETRIX, INC.
3380 CENTRAL EXPRESSWAY
SANTA CLARA, CA 95051
(Name and address of agent for service)
(408) 731-5000
(Telephone number, including area code, of agent for service)
CALCULATION OF REGISTRATION FEE
TITLE OF SECURITIES TO BE
REGISTERED (1)
AMOUNT TO BE REGISTERED (2)
PROPOSED MAXIMUM OFFERING PRICE PER SHARE (3)
PROPOSED MAXIMUM AGGREGATE OFFERING
PRICE (3)
AMOUNT OF REGISTRATION
FEE (3)
Common Stock (par value $.01)
5,000,000
$39.28
$196,399,553.81
$49,098.89
(1)
This Registration Statement covers shares of Common Stock of Affymetrix, Inc. which may be offered or sold pursuant to the Affymetrix, Inc. 2000 Equity Incentive Plan (the "Plan"). This Registration Statement
shall also cover any additional shares of Common Stock which become issuable under the Plan by reason of any stock dividend, stock split, recapitalization or other similar transaction effected without the receipt of consideration which results in an
increase in the number of the outstanding shares of Common Stock of Affymetrix, Inc. This Registration Statement also relates to the Rights to purchase shares of Series B Junior Participating Stock of Affymetrix, Inc. which are
attached to all shares of Common Stock outstanding as of, and issued subsequent to, October 15, 1998, pursuant to Affymetrix, Inc.'s Rights Agreement dated as of October 15, 1998, as amended. Until the occurrence of certain prescribed
events, the Rights are not exercisable, are evidenced by the certificates for the Common Stock, and will be transferred with and only with such stock.
(2)
As adopted by the Board of Directors of the Registrant effective March 9, 2000 and approved by the stockholders on June 8, 2000, the Plan authorizes issuance of 2,500,000 shares, or 5,000,000 shares as adjusted for the 2 for 1 stock split
effective August 21, 2000.
(3)
Calculated solely for purposes of this offering under Rules 457(c) and 457(h) of the Securities Act of 1933, as amended, based upon the sum of (a) the aggregate offering price with respect to 2,210,800 stock options for which the exercise
price is known, and (b) 2,789,200 stock options for which the exercise price is not known multiplied by the the average of the high and low prices of the Registrant's Common Stock reported on the Nasdaq National Market on April 11,
2001.
PART I
INFORMATION REQUIRED IN SECTION 10(a) PROSPECTUS
The information required in Part I of Form S-8 to be contained in a prospectus meeting the requirements of Section 10(a) of
the Securities Act of 1933, as amended (the "Securities Act"), is not required to be filed with the Securities and Exchange Commission and is omitted from this Registration Statement in accordance
with the explanatory note to Part I of Form S-8 and Rule 428 and under the Securities Act.
PART II
INFORMATION REQUIRED IN THE REGISTRATION STATEMENT
Item 3. INCORPORATION OF DOCUMENTS BY REFERENCE
Affymetrix, Inc. (the "Registrant") hereby incorporates by reference into this Registration Statement the following documents previously filed with the
Securities and Exchange Commission (the "SEC"):
•
Annual
Report on Form 10-K for the year ended December 31, 2000;
•
Current
Reports on Form 8-K filed on January 12, 2001, March 7, 2001, March 26, 2001, and April 3, 2001.
•
Amendment No.
1 to Current Report on Form 8-K/A filed on January 12, 2001 amending Current Report on Form 8-K filed on November 13,
2000.
•
Form 8-A
filed on October 16, 1998, as amended by Form 8-A/A filed on March 29, 2000; and
•
Registration
Statement No. 0-28218 on Form 8-A filed with the SEC on April 16, 1996 pursuant to
Section 12 of the Securities Exchange Act of 1934, as amended, with amendments thereto, in which there is described the terms, rights and provisions applicable to the Registrant's Common Stock.
All
reports and definitive proxy or information statements filed pursuant to Section 13(a), 13(c), 14 or 15(d) of the 1934 Act after the date of this Registration Statement and
prior to the filing of a post-effective amendment which indicates that all securities offered hereby have been sold or which deregisters all securities then remaining unsold shall be
deemed to be incorporated by reference into this Registration Statement and to be a part hereof from the date of filing of such documents.
Item 4. DESCRIPTION OF SECURITIES
Not Applicable.
Item 5. INTERESTS OF NAMED EXPERTS AND COUNSEL
The legality of the shares of Common Stock offered hereby has been passed upon for the Registrant by Vern Norviel, Esq. Mr. Norviel is Senior Vice
President, General Counsel and Corporate Secretary of Affymetrix, Inc.
Item 6. INDEMNIFICATION OF DIRECTORS AND OFFICERS
Section 145 of the Delaware General Corporation law empowers a Delaware corporation to indemnify any person who is, or is threatened to be made, a party
to any threatened, pending or completed legal action, suit or proceedings, whether civil, criminal, administrative or investigative (other
2
than by or in the right of such corporation), by reason of the fact that such person is or was an officer or director of such corporation, or is or was serving at the request of such corporation as a
director,
officer, employee or agent of another corporation or enterprise. The indemnity may include expenses (including attorneys' fees), judgements, fines and amounts paid in settlement actually and
reasonably incurred by such person in connection with such action, suit or proceeding, provided that such person acted in good faith and in a manner he or she reasonably believed to be in or not
opposed to the corporation's best interests, and, for criminal proceedings, had no reasonable cause to believe his or her conduct was illegal. A Delaware corporation may indemnify officers and
directors in an action by or in the right of the corporation under the same conditions, except that no indemnification is permitted without judicial approval if the officer or director is adjudged to
be liable to the corporation in the performance of his duty. Where an officer or director is successful on the merits or otherwise in the defense of any action referred to above, the corporation must
indemnify him or her against the expenses which such officer or director actually and reasonably incurred.
In
accordance with Delaware law, Registrant's restated certificate of incorporation contains a provision to limit the personal liability of Registrant's directors for violations of
their fiduciary duty as a director. This provision eliminates each director's liability to Registrant or Registrant's stockholders for monetary damages except (i) for any breach of the
director's duty of loyalty to Registrant or Registrant's stockholders, (ii) for acts or omissions not in good faith or which involve intentional misconduct or a knowing violation of law,
(iii) under Section 174 of the Delaware General Corporation law providing for liability of directors for unlawful payment of dividends or unlawful stock purchases or redemptions, or
(iv) for any transaction from which a director derived an improper personal benefit. The effect of this provision is to eliminate the personal liability of directors for monetary damages for
actions involving a breach of their fiduciary duty of care, including any such actions involving gross negligence.
Registrant's
restated certificate of incorporation and bylaws provide for indemnification of its officers and directors to the fullest extent permitted by applicable law.
Registrant
has entered into indemnification agreements with each director and executive officer which provide indemnification to such directors and executive officers under certain
circumstances for acts or omissions which may not be covered by directors' and officers' liability insurance.
Item 7. EXEMPTION FROM REGISTRATION CLAIMED
Not Applicable.
3
Item 8. EXHIBITS
Exhibit Number
Exhibit
(1)4.1
Restated Certificate of Incorporation of Affymetrix, Inc.
(2)4.2
Bylaws of Affymetrix, Inc.
(3)4.3
Rights Agreement, dated as of October 15, 1998, between Affymetrix, Inc. and American Stock Transfer & Trust Company, as Rights Agent
(4)4.4
Amendment No. 1 to Rights Agreement, dated as of February 7, 2000, between Affymetrix, Inc. and American Stock Transfer & Trust Company, as Rights Agent
5.1
Opinion of Vern Norviel, Esq., Senior Vice President, General Counsel, and Corporate Secretary
23.1
Consent of Ernst & Young LLP, Independent Auditors
23.2
Consent of Vern Norviel, Esq. (included in Exhibit 5.1)
24.1
Power of Attorney (included on the signature page hereto)
99.1
Affymetrix, Inc. 2000 Equity Incentive Plan
(1)
Incorporated
by reference to Exhibit 3.1 to our Form 8-K as filed on June 13, 2000 (File No. 000-28218).
(2)
Incorporated
by reference to Appendix C to our definitive proxy statement on Schedule 14A as filed on April 29, 1998 (File No. 00-28218).
(3)
Incorporated
by reference to Exhibit 1 of our Form 8-A as filed on October 16, 1998 (File No. 000-28218).
(4)
Incorporated
by reference to Exhibit 4.1 of our Form 8-A/A as filed on March 29, 2000 (File No. 000-28218).
Item 9. UNDERTAKINGS
A.  The
undersigned Registrant hereby undertakes: (1) to file, during any period in which offers or sales are being made, a post-effective amendment
to this Registration Statement (i) to include any prospectus required by Section 10(a)(3) of the 1933 Act, (ii) to reflect in the prospectus any facts or events arising after the
effective date of this Registration Statement (or the most recent post-effective amendment thereof) which, individually or in the aggregate, represent a fundamental change in the
information set forth in this Registration Statement and (iii) to include any material information with respect to the plan of distribution not previously disclosed in this Registration
Statement or any material change to such information in this Registration Statement; provided, however, that clauses (1)(i) and (1)(ii) shall not apply if the information required to be
included in a post-effective amendment by those paragraphs is contained in periodic reports filed by the Registrant pursuant to Section 13 or Section 15(d) of the 1934 Act
that are incorporated by reference into this Registration Statement; (2) that for the purpose of determining any liability under the 1933 Act each such post-effective amendment
shall be deemed to be a new registration statement relating to the securities offered therein and the offering of such securities at that time shall be deemed to be the initial bona fide offering
thereof; and (3) to remove from registration by means of a post-effective amendment any
4
of the securities being registered which remain unsold at the termination of the Affymetrix, Inc. 2000 Equity Incentive Plan.
B.  The
undersigned Registrant hereby undertakes that, for purposes of determining any liability under the 1933 Act, each filing of the Registrant's annual report
pursuant to Section 13(a) or Section 15(d) of
the 1934 Act that is incorporated by reference into this Registration Statement shall be deemed to be a new registration statement relating to the securities offered therein, and the offering of such
securities at that time shall be deemed to be the initial bona fide offering thereof.
C.  Insofar
as indemnification for liabilities arising under the 1933 Act may be permitted to directors, officers or controlling persons of the Registrant pursuant to
the indemnification provisions summarized in Item 6 or otherwise, the Registrant has been advised that, in the opinion of the SEC, such indemnification is against public policy as expressed in the
1933 Act, and is, therefore, unenforceable. In the event that a claim for indemnification against such liabilities (other than the payment by the Registrant of expenses incurred or paid by a director,
officer or controlling person of the Registrant in the successful defense of any action, suit or proceeding) is asserted by such director, officer or controlling person in connection with the
securities being registered, the Registrant will, unless in the opinion of its counsel the matter has been settled by controlling precedent, submit to a court of appropriate jurisdiction the question
whether such indemnification by it is against public policy as expressed in the 1933 Act and will be governed by the final adjudication of such issue.
5
SIGNATURES
Pursuant
to the requirements of the Securities Act of 1933, as amended, the Registrant certifies that it has reasonable grounds to believe that it meets all of the requirements for
filing on Form S-8, and has duly caused this Registration Statement to be signed on its behalf by the undersigned, thereunto duly authorized, in the City of Santa Clara, State of
California on this 18th day of April, 2001.
AFFYMETRIX, INC.
By:
/s/
VERN NORVIEL
Vern Norviel
Senior Vice President, General
Counsel and Corporate Secretary
POWER OF ATTORNEY
KNOW
ALL PERSONS BY THESE PRESENTS:
That
the undersigned officers and directors of Affymetrix, Inc., a Delaware corporation, do hereby constitute and appoint Stephen P.A. Fodor and Vern Norviel, and either of
them, the lawful attorneys-in-fact and agents with full power and authority to do any and all acts and things and to execute any and all instruments which said attorneys and
agents, and either one of them, determine may be necessary or advisable or required to enable said corporation to comply with the Securities Act of 1933, as amended, and any rules or regulations or
requirements of the Securities and Exchange Commission in connection with this Registration Statement. Without limiting the generality of the
foregoing power and authority, the powers granted include the power and authority to sign the names of the undersigned officers and directors in the capacities indicated below to this Registration
Statement, to any and all amendments, both pre-effective and post-effective, and supplements to this Registration Statement, and to any and all instruments or documents filed
as part of or in conjunction with this Registration Statement or amendments or supplements thereof, and each of the undersigned hereby ratifies and confirms all that said attorneys and agents, or
either one of them, shall do or cause to be done by virtue hereof. This Power of Attorney may be signed in several counterparts.
IN
WITNESS WHEREOF, each of the undersigned has executed this Power of Attorney as of the date indicated.
Pursuant
to the requirements of the Securities Act of 1933, as amended, this Registration Statement has been signed below by the following persons in the capacities and on the dates
indicated.
Signature
Title
Date
/s/
STEPHEN P.A. FODOR
Stephen P.A. Fodor, Ph.D.
Chief Executive Officer and Chairman of the Board
April 18, 2001
/s/
EDWARD M. HURWITZ
Edward M. Hurwitz
Senior Vice President and Chief Financial Officer (Principal Financial and Accounting Officer)
April 18, 2001
6
/s/
JOHN D. DIEKMAN
John D. Diekman, Ph.D.
Director
April 18, 2001
/s/
PAUL BERG
Paul Berg, Ph.D.
Director
April 18, 2001
/s/
VERNON R. LOUCKS, JR.
Vernon R. Loucks, Jr.
Director
April 18, 2001
/s/
DAVID B. SINGER
David B. Singer
Director
April 18, 2001
/s/
LUBERT STRYER
Lubert Stryer, M.D.
Director
April 18, 2001
/s/
JOHN A. YOUNG
John A. Young
Director
April 18, 2001
7
EXHIBIT INDEX
Exhibit Number
Exhibit
(1)4.1
Restated Certificate of Incorporation of Affymetrix, Inc.
(2)4.2
Bylaws of Affymetrix, Inc.
(3)4.3
Rights Agreement, dated as of October 15, 1998, between Affymetrix, Inc. and American Stock Transfer & Trust Company, as Rights Agent
(4)4.4
Amendment No. 1 to Rights Agreement, dated as of February 7, 2000, between Affymetrix, Inc. and American Stock Transfer & Trust Company, as Rights Agent
5.1
Opinion of Vern Norviel, Esq., Senior Vice President, General Counsel, and Corporate Secretary
23.1
Consent of Ernst & Young LLP, Independent Auditors
23.2
Consent of Vern Norviel, Esq. (included in Exhibit 5.1)
24.1
Power of Attorney (included on the signature page hereto)
99.1
Affymetrix, Inc. 2000 Equity Incentive Plan
(1)
Incorporated
by reference to Exhibit 3.1 to our Form 8-K as filed on June 13, 2000 (File No. 000-28218).
(2)
Incorporated
by reference to Appendix C to our definitive proxy statement on Schedule 14A as filed on April 29, 1998 (File No. 000-28218).
(3)
Incorporated
by reference to Exhibit 1 of our Form 8-A as filed on October 16, 1998 (File No. 000-28218).
(4)
Incorporated
by reference to Exhibit 4.1 of our Form 8-A/A as filed on March 29, 2000 (File No. 000-28218).
QuickLinks
PART I INFORMATION REQUIRED IN SECTION 10(a) PROSPECTUS
PART II INFORMATION REQUIRED IN THE REGISTRATION STATEMENT
SIGNATURES
POWER OF ATTORNEY
EXHIBIT INDEX