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<TITLE>s-8 plan changes 2000</TITLE>
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<B><FONT SIZE=2><P ALIGN="CENTER">As Filed With the Securities and Exchange Commission on March 29, 2002</P>
<U><P ALIGN="RIGHT">Registration No.</B> <B>333-61829</P>
</U></FONT><P ALIGN="CENTER">UNITED STATES</P>
<P ALIGN="CENTER">SECURITIES AND EXCHANGE COMMISSION</P>
<FONT SIZE=2><P ALIGN="CENTER">Washington, D.C. 20549</P>
<P ALIGN="CENTER">_______________________</P>
</FONT><P ALIGN="CENTER">AMENDMENT NO. 1</P>
<P ALIGN="CENTER">TO</P>
<P ALIGN="CENTER">FORM S-8</P>
<FONT SIZE=2><P ALIGN="CENTER">Registration Statement Under</P>
<P ALIGN="CENTER">The Securities Act of 1933</P>
</FONT><P ALIGN="CENTER">________________________</P>
<FONT SIZE=4><P ALIGN="CENTER">TRIPOS, INC.</P>
</B></FONT><FONT SIZE=2><P ALIGN="CENTER">(Exact name of registrant as specified in its charter)</P></FONT>
<P ALIGN="CENTER"><CENTER><TABLE CELLSPACING=0 BORDER=0 CELLPADDING=7 WIDTH=600>
<TR><TD WIDTH="34%" VALIGN="TOP">
<P ALIGN="CENTER"><B><FONT SIZE=2>Utah</B></FONT></TD>
<TD WIDTH="31%" VALIGN="TOP">
<P>&nbsp;</TD>
<TD WIDTH="35%" VALIGN="TOP">
<B><FONT SIZE=2><P ALIGN="CENTER">43-1454986</B></FONT></TD>
</TR>
<TR><TD WIDTH="34%" VALIGN="TOP">
<FONT SIZE=2><P ALIGN="CENTER">(State or other jurisdiction of</FONT></TD>
<TD WIDTH="31%" VALIGN="TOP">
<P>&nbsp;</TD>
<TD WIDTH="35%" VALIGN="TOP">
<FONT SIZE=2><P ALIGN="CENTER">(I.R.S. Employer</FONT></TD>
</TR>
<TR><TD WIDTH="34%" VALIGN="TOP">
<FONT SIZE=2><P ALIGN="CENTER">incorporation or organization)</FONT></TD>
<TD WIDTH="31%" VALIGN="TOP">
<B><FONT SIZE=2><P ALIGN="CENTER">1699 South Hanley Road</B></FONT></TD>
<TD WIDTH="35%" VALIGN="TOP">
<FONT SIZE=2><P ALIGN="CENTER">Identification No.)</FONT></TD>
</TR>
<TR><TD WIDTH="34%" VALIGN="TOP">
<P>&nbsp;</TD>
<TD WIDTH="31%" VALIGN="TOP">
<B><FONT SIZE=2><P ALIGN="CENTER">St. Louis, Missouri 63144</B></FONT></TD>
<TD WIDTH="35%" VALIGN="TOP">
<P>&nbsp;</TD>
</TR>
</TABLE>
</CENTER></P>

<FONT SIZE=2><P ALIGN="CENTER">(Address of Principal Executive Offices)</P>
</FONT><P ALIGN="CENTER">_________________________</P>
<B><P ALIGN="CENTER">TRIPOS, INC. 1994 EMPLOYEE STOCK PURCHASE PLAN</P>
<P ALIGN="CENTER">and</P>
<P ALIGN="CENTER">TRIPOS, INC. 1994 STOCK OPTION PLAN</P>
</B><FONT SIZE=2><P ALIGN="CENTER">(Full title of the plans)</P>
</FONT><U><P ALIGN="CENTER">&nbsp;</P>
</U><B><P ALIGN="CENTER">JOHN D. YINGLING</P>
<P ALIGN="CENTER">Vice President and Chief Accounting Officer</P>
<FONT SIZE=2><P ALIGN="CENTER">Tripos, Inc.</P>
<P ALIGN="CENTER">1699 South Hanley Road</P>
<P ALIGN="CENTER">St. Louis, Missouri 63144</P>
</B><P ALIGN="CENTER">(Name and address of agent for service)</P>
<P ALIGN="CENTER">Telephone number, including area code, of agent for service: <B>(314) 647-1099</P>
</B><P ALIGN="CENTER">________________________</P>
</FONT><U><P ALIGN="CENTER">&nbsp;</P>
</U><P ALIGN="CENTER">Copy to:</P>
<B><P ALIGN="CENTER">ROBERT M. LAROSE, ESQ.</P>
<FONT SIZE=2><P ALIGN="CENTER">Thompson Coburn LLP</P>
<P ALIGN="CENTER">One Firstar Plaza</P>
<P ALIGN="CENTER">St. Louis, Missouri 63101</P>
<P ALIGN="CENTER">(314) 552-6000</P>
</B><P ALIGN="CENTER">CALCULATION OF REGISTRATION FEE</P></FONT>
<P ALIGN="CENTER"><CENTER><TABLE CELLSPACING=0 BORDER=0 CELLPADDING=8 WIDTH=685>
<TR><TD WIDTH="31%" VALIGN="TOP">
<P ALIGN="CENTER"><FONT SIZE=2>Title of each class of securities to be registered </FONT></TD>
<TD WIDTH="14%" VALIGN="TOP">
<FONT SIZE=2><P ALIGN="CENTER">Amount to be registered <SUP>(2)</SUP></FONT></TD>
<TD WIDTH="19%" VALIGN="TOP">
<FONT SIZE=2><P ALIGN="CENTER">Proposed maximum offering price per unit <SUP>(3)</SUP></FONT></TD>
<TD WIDTH="21%" VALIGN="TOP">
<FONT SIZE=2><P ALIGN="CENTER">Proposed maximum aggregate offering price <SUP>(3)</SUP> </FONT></TD>
<TD WIDTH="16%" VALIGN="TOP">
<FONT SIZE=2><P ALIGN="CENTER">Amount of registration fee</FONT></TD>
</TR>
<TR><TD WIDTH="31%" VALIGN="TOP">
<FONT SIZE=2><P ALIGN="CENTER">Common Stock, $.005 par value<SUP>(1)</SUP> &#9;</FONT></TD>
<TD WIDTH="14%" VALIGN="TOP">
<FONT SIZE=2><P ALIGN="CENTER">400,000</FONT></TD>
<TD WIDTH="19%" VALIGN="TOP">
<FONT SIZE=2><P ALIGN="CENTER">$23.92</FONT></TD>
<TD WIDTH="21%" VALIGN="TOP">
<FONT SIZE=2><P ALIGN="CENTER">&nbsp;$9,568,000 </FONT></TD>
<TD WIDTH="16%" VALIGN="TOP">
<FONT SIZE=2><P ALIGN="CENTER">&nbsp;$880.26</FONT></TD>
</TR>
<TR><TD WIDTH="31%" VALIGN="TOP">
<P>&nbsp;</TD>
<TD WIDTH="14%" VALIGN="TOP">
<P>&nbsp;</TD>
<TD WIDTH="19%" VALIGN="TOP">
<P>&nbsp;</TD>
<TD WIDTH="21%" VALIGN="TOP">
<P>&nbsp;</TD>
<TD WIDTH="16%" VALIGN="TOP">
<P>&nbsp;</TD>
</TR>
</TABLE>
</CENTER></P>
<DIR>
<DIR>
<DIR>

<FONT SIZE=1><P ALIGN="JUSTIFY">&#9;(1)&#9;Includes one attached preferred stock purchase right per share.</P>
<P ALIGN="JUSTIFY">&#9;(2)&#9;The shares being registered hereby are reserved for issuance pursuant to the Tripos, Inc. 1994 Stock Option Plan. </P>
<P ALIGN="JUSTIFY">&#9;(3)&#9;Estimated solely for purposes of computing the Registration Fee pursuant to the provisions of Rule 457(h), based upon a price of $23.92 per share, being the average of the high and low transaction prices of the Registrant's common stock per share as reported on the Nasdaq National Market on March 26, 2002. </P>
</FONT><U><P ALIGN="JUSTIFY">&nbsp;</P></DIR>
</DIR>
</DIR>

</U><P ALIGN="JUSTIFY">&nbsp;</P>
<B><P ALIGN="CENTER">TRIPOS, INC.</P>
<P ALIGN="CENTER">1994 EMPLOYEE STOCK PURCHASE PLAN</P>
<P ALIGN="CENTER">and</P>
<P ALIGN="CENTER">TRIPOS, INC.</P>
<P ALIGN="CENTER">1994 STOCK OPTION PLAN</P>
</B><U><P ALIGN="CENTER">EXPLANATORY NOTE</P>
</U><P ALIGN="CENTER">&#9;This Amendment No. 1 to Registration Statement on Form S-8 is being filed by Tripos, Inc. in connection with the registration of an additional 400,000 shares of common stock, $.005 par value per share, to be issued pursuant to the Tripos, Inc. 1994 Stock Option Plan. The contents of the Registration Statement on Form S-8 (Reg. No. 333-61829) filed by Tripos, Inc. with the Securities and Exchange Commission on August 19, 1998, other than Item 5, are incorporated herein by reference. </P>
<P ALIGN="JUSTIFY">&nbsp;</P>
<P ALIGN="JUSTIFY">Item 5. &#9;Not Applicable.</P>
<P ALIGN="JUSTIFY">Item 8.&#9;<U>Exhibits</U>.</P>
<P ALIGN="JUSTIFY">See Exhibit Index located at page 5 hereof.</P>
<P ALIGN="JUSTIFY">&nbsp;</P>
<P ALIGN="JUSTIFY">&nbsp;</P>
<P ALIGN="JUSTIFY">&nbsp;</P>
<P ALIGN="JUSTIFY">&nbsp;</P>
<P ALIGN="JUSTIFY">&nbsp;</P>
<P ALIGN="JUSTIFY">&nbsp;</P>
<P ALIGN="JUSTIFY">&nbsp;</P>
<P ALIGN="JUSTIFY">&#9;<U>SIGNATURES</P>
</U><I><P ALIGN="JUSTIFY">&#9;&#9;</I>Pursuant to the requirements of the Securities Act of 1933, the Registrant certifies that it has reasonable grounds to believe that it meets all of the requirements for filing on Form S-8 and has duly caused this Amendment No. 1 to Registration Statement (File No. 333-61829) to be signed on its behalf by the undersigned, thereunto duly authorized, in the County of St. Louis, State of Missouri, on the 29<SUP>th</SUP> day of March 2002.</P>
<P ALIGN="JUSTIFY">&#9;&#9;</P>
<TABLE CELLSPACING=0 BORDER=0 CELLPADDING=7 WIDTH=638>
<TR><TD WIDTH="45%" VALIGN="TOP">
<P>&nbsp;</TD>
<TD WIDTH="55%" VALIGN="TOP">
<P ALIGN="JUSTIFY">TRIPOS, INC.</TD>
</TR>
<TR><TD WIDTH="45%" VALIGN="TOP">
<P>&nbsp;</TD>
<TD WIDTH="55%" VALIGN="TOP">
<P ALIGN="JUSTIFY">&nbsp;</TD>
</TR>
<TR><TD WIDTH="45%" VALIGN="TOP">
<P>&nbsp;</TD>
<TD WIDTH="55%" VALIGN="TOP">
<P ALIGN="JUSTIFY">By: ___________________________</TD>
</TR>
<TR><TD WIDTH="45%" VALIGN="TOP">
<P>&nbsp;</TD>
<TD WIDTH="55%" VALIGN="TOP">
<P ALIGN="JUSTIFY">John P. McAlister, III</TD>
</TR>
<TR><TD WIDTH="45%" VALIGN="TOP">
<P>&nbsp;</TD>
<TD WIDTH="55%" VALIGN="TOP">
<P ALIGN="JUSTIFY">President and Chief Executive Officer</TD>
</TR>
</TABLE>
<DIR>
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<DIR>

<P>&#9;&#9;&#9;</P>
<P>&#9;&#9;&#9;</P>
<P>&nbsp;</P></DIR>
</DIR>
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<P ALIGN="JUSTIFY">&#9;Pursuant to the requirements of the Securities Act of 1933, this Amendment No.&nbsp;1 to Registration Statement has been signed by the following persons in the capacities and on the dates indicated.</P>
<TABLE CELLSPACING=0 BORDER=0 CELLPADDING=7 WIDTH=618>
<TR><TD WIDTH="33%" VALIGN="TOP">
<P ALIGN="CENTER"><B>Signature</B></TD>
<TD WIDTH="41%" VALIGN="TOP">
<B><P ALIGN="CENTER">Title</B></TD>
<TD WIDTH="26%" VALIGN="TOP">
<B><P ALIGN="CENTER">Date</B></TD>
</TR>
<TR><TD WIDTH="33%" VALIGN="TOP">
<P>&nbsp;</TD>
<TD WIDTH="41%" VALIGN="TOP">
<P>&nbsp;</TD>
<TD WIDTH="26%" VALIGN="TOP">
<P>&nbsp;</TD>
</TR>
<TR><TD WIDTH="33%" VALIGN="TOP">
<U><P>_______________________</U></TD>
<TD WIDTH="41%" VALIGN="TOP">
<P>President, Chief Executive</TD>
<TD WIDTH="26%" VALIGN="TOP">
<P>March 29, 2002</TD>
</TR>
<TR><TD WIDTH="33%" VALIGN="TOP">
<P>John P. McAlister, III</TD>
<TD WIDTH="41%" VALIGN="TOP">
<P>Officer and Director</TD>
<TD WIDTH="26%" VALIGN="TOP">
<P>&nbsp;</TD>
</TR>
<TR><TD WIDTH="33%" VALIGN="TOP">
<P>Principal Executive Officer</TD>
<TD WIDTH="41%" VALIGN="TOP">
<P>&nbsp;</TD>
<TD WIDTH="26%" VALIGN="TOP">
<P>&nbsp;</TD>
</TR>
<TR><TD WIDTH="33%" VALIGN="TOP">
<P>&nbsp;</TD>
<TD WIDTH="41%" VALIGN="TOP">
<P>&nbsp;</TD>
<TD WIDTH="26%" VALIGN="TOP">
<P>&nbsp;</TD>
</TR>
<TR><TD WIDTH="33%" VALIGN="TOP">
<U><P>_______________________</U></TD>
<TD WIDTH="41%" VALIGN="TOP">
<P>Senior Vice President, Chief</TD>
<TD WIDTH="26%" VALIGN="TOP">
<P>March 29, 2002</TD>
</TR>
<TR><TD WIDTH="33%" VALIGN="TOP">
<P>James Rubin&#9;</TD>
<TD WIDTH="41%" VALIGN="TOP">
<P>Financial Officer and Secretary</TD>
<TD WIDTH="26%" VALIGN="TOP">
<P>&nbsp;</TD>
</TR>
<TR><TD WIDTH="33%" VALIGN="TOP">
<P>Principal Financial Officer</TD>
<TD WIDTH="41%" VALIGN="TOP">
<P>&nbsp;</TD>
<TD WIDTH="26%" VALIGN="TOP">
<P>&nbsp;</TD>
</TR>
<TR><TD WIDTH="33%" VALIGN="TOP">
<P>&nbsp;</TD>
<TD WIDTH="41%" VALIGN="TOP">
<P>&nbsp;</TD>
<TD WIDTH="26%" VALIGN="TOP">
<P>&nbsp;</TD>
</TR>
<TR><TD WIDTH="33%" VALIGN="TOP">
<U><P>_______________________</U></TD>
<TD WIDTH="41%" VALIGN="TOP">
<P>Vice President, Chief Accounting</TD>
<TD WIDTH="26%" VALIGN="TOP">
<P>March 29, 2002</TD>
</TR>
<TR><TD WIDTH="33%" VALIGN="TOP">
<P>John D. Yingling</TD>
<TD WIDTH="41%" VALIGN="TOP">
<P>Officer and Assistant Secretary</TD>
<TD WIDTH="26%" VALIGN="TOP">
<P>&nbsp;</TD>
</TR>
<TR><TD WIDTH="33%" VALIGN="TOP">
<P>Principal Accounting Officer</TD>
<TD WIDTH="41%" VALIGN="TOP">
<P>&nbsp;</TD>
<TD WIDTH="26%" VALIGN="TOP">
<P>&nbsp;</TD>
</TR>
<TR><TD WIDTH="33%" VALIGN="TOP">
<P>&nbsp;</TD>
<TD WIDTH="41%" VALIGN="TOP">
<P>&nbsp;</TD>
<TD WIDTH="26%" VALIGN="TOP">
<P>&nbsp;</TD>
</TR>
<TR><TD WIDTH="33%" VALIGN="TOP">
<U><P>_________*_____________</U></TD>
<TD WIDTH="41%" VALIGN="TOP">
<P>Chairman of the Board</TD>
<TD WIDTH="26%" VALIGN="TOP">
<P>March 29, 2002</TD>
</TR>
<TR><TD WIDTH="33%" VALIGN="TOP">
<P>Ralph S. Lobdell</TD>
<TD WIDTH="41%" VALIGN="TOP">
<P>of Directors</TD>
<TD WIDTH="26%" VALIGN="TOP">
<P>&nbsp;</TD>
</TR>
<TR><TD WIDTH="33%" VALIGN="TOP">
<P>&nbsp;</TD>
<TD WIDTH="41%" VALIGN="TOP">
<P>&nbsp;</TD>
<TD WIDTH="26%" VALIGN="TOP">
<P>&nbsp;</TD>
</TR>
<TR><TD WIDTH="33%" VALIGN="TOP">
<U><P>_________*_____________</U></TD>
<TD WIDTH="41%" VALIGN="TOP">
<P>Director</TD>
<TD WIDTH="26%" VALIGN="TOP">
<P>March 29, 2002</TD>
</TR>
<TR><TD WIDTH="33%" VALIGN="TOP">
<P>Gary Meredith</TD>
<TD WIDTH="41%" VALIGN="TOP">
<P>&nbsp;</TD>
<TD WIDTH="26%" VALIGN="TOP">
<P>&nbsp;</TD>
</TR>
<TR><TD WIDTH="33%" VALIGN="TOP">
<P>&nbsp;</TD>
<TD WIDTH="41%" VALIGN="TOP">
<P>&nbsp;</TD>
<TD WIDTH="26%" VALIGN="TOP">
<P>&nbsp;</TD>
</TR>
<TR><TD WIDTH="33%" VALIGN="TOP">
<U><P>_________*_____________</U></TD>
<TD WIDTH="41%" VALIGN="TOP">
<P>Director</TD>
<TD WIDTH="26%" VALIGN="TOP">
<P>March 29, 2002</TD>
</TR>
<TR><TD WIDTH="33%" VALIGN="TOP">
<P>Stewart Carrell</TD>
<TD WIDTH="41%" VALIGN="TOP">
<P>&nbsp;</TD>
<TD WIDTH="26%" VALIGN="TOP">
<P>&nbsp;</TD>
</TR>
<TR><TD WIDTH="33%" VALIGN="TOP">
<P>&nbsp;</TD>
<TD WIDTH="41%" VALIGN="TOP">
<P>&nbsp;</TD>
<TD WIDTH="26%" VALIGN="TOP">
<P>&nbsp;</TD>
</TR>
<TR><TD WIDTH="33%" VALIGN="TOP">
<U><P>_________*_____________</U></TD>
<TD WIDTH="41%" VALIGN="TOP">
<P>Director</TD>
<TD WIDTH="26%" VALIGN="TOP">
<P>March 29, 2002</TD>
</TR>
<TR><TD WIDTH="33%" VALIGN="TOP">
<P>Ferid Murad</TD>
<TD WIDTH="41%" VALIGN="TOP">
<P>&nbsp;</TD>
<TD WIDTH="26%" VALIGN="TOP">
<P>&nbsp;</TD>
</TR>
<TR><TD WIDTH="33%" VALIGN="TOP">
<P>&nbsp;</TD>
<TD WIDTH="41%" VALIGN="TOP">
<P>&nbsp;</TD>
<TD WIDTH="26%" VALIGN="TOP">
<P>&nbsp;</TD>
</TR>
<TR><TD WIDTH="33%" VALIGN="TOP">
<U><P>_________*_____________</U></TD>
<TD WIDTH="41%" VALIGN="TOP">
<P>Director</TD>
<TD WIDTH="26%" VALIGN="TOP">
<P>March 29, 2002</TD>
</TR>
<TR><TD WIDTH="33%" VALIGN="TOP">
<P>Alfred Alberts</TD>
<TD WIDTH="41%" VALIGN="TOP">
<P>&nbsp;</TD>
<TD WIDTH="26%" VALIGN="TOP">
<P>&nbsp;</TD>
</TR>
</TABLE>

<P ALIGN="JUSTIFY">&nbsp;</P>
<P>&nbsp;</P>
<P>*By__________________________</P>
<P>John P. McAlister, III</P>
<P>Attorney-in-fact</P>
<P>John P. McAlister, III, by signing his name hereto, does sign this document on behalf of the individuals named above, pursuant to a power of attorney duly executed by such individuals, previously filed as Exhibit 24 to the Registration Statement on Form S-8 filed on August 19, 1998. </P>
<P>&nbsp;</P>
<P>&nbsp;</P>
<U><P>EXHIBIT INDEX</P>
<P ALIGN="JUSTIFY">Exhibit No.</U>&#9;</P>
<TABLE CELLSPACING=0 BORDER=0 CELLPADDING=14 WIDTH=697>
<TR><TD WIDTH="93%" VALIGN="TOP">
<P ALIGN="JUSTIFY">4.1&#9;Amended and Restated Articles of Incorporation, dated January 26, 1996, incorporated by reference to the Registrant's Annual Report on Form 10-K for the fiscal year ended December 31, 1995. </P>
<P ALIGN="JUSTIFY">&nbsp;</P>
<P ALIGN="JUSTIFY">4.2&#9;Articles of Amendment to the Articles of Incorporation, dated February 4, 2000, incorporated by reference to Exhibit 3.3 to the Registrant's Annual Report on Form 10-K for the fiscal year ended December 31, 2000. </P>
<P ALIGN="JUSTIFY">4.3&#9;Amended and Restated Bylaws, incorporated by reference to the Registrant's Registration Statement on Form 10 dated May 27, 1994.</P>
<P ALIGN="JUSTIFY">&nbsp;</P>
<P ALIGN="JUSTIFY">4.4&#9;Investor's Rights Agreement, dated February 4, 2000, between LION bioscience AG and Tripos, Inc., incorporated by reference to Exhibit 4.1 to the Registrant's Annual Report on Form 10-K for the fiscal year ended December 31, 1999. </P>
<P ALIGN="JUSTIFY">4.5&#9;Rights Agreement, dated January 26, 1996, between Tripos, Inc. and Boatmen's Trust Company, as Rights Agent, incorporated by reference to the Registrant's Annual Report on Form 10-K for the fiscal year ended December 31, 1995. </P>
<P ALIGN="JUSTIFY">5.1&#9;Opinion of Thompson&nbsp;Coburn LLP as to the legality of the securities being registered.*</P>
<P ALIGN="JUSTIFY">23.1&#9;Consent of Ernst &amp; Young LLP.*</P>
<P ALIGN="JUSTIFY">&nbsp;</P>
<P ALIGN="JUSTIFY">23.2&#9;Consent of Thompson Coburn LLP (included in Exhibit 5.1).</P>
<P ALIGN="JUSTIFY">24.1&#9;Power of Attorney.**</P>
<P ALIGN="JUSTIFY">________________</P>
<P ALIGN="JUSTIFY">*&nbsp;&nbsp;Filed herewith</P>
<P ALIGN="JUSTIFY">** Previously filed</TD>
<TD WIDTH="7%" VALIGN="TOP">
<P>&nbsp;</TD>
</TR>
</TABLE>

<P ALIGN="JUSTIFY">&nbsp;</P>
<P ALIGN="JUSTIFY">&nbsp;</P>
<P ALIGN="JUSTIFY">&nbsp;</P>
<P ALIGN="JUSTIFY">Exhibit 5.1</P>
<P ALIGN="JUSTIFY">&nbsp;</P>
<P ALIGN="JUSTIFY">March 29, 2002</P>
<FONT SIZE=1><P ALIGN="JUSTIFY"><A NAME="Internet"></A></P>
</FONT><P>Tripos, Inc. </P>
<P>1699 South Hanley Road</P>
<P>St. Louis, Missouri 63144</P>
<P>Re:&#9;Registration Statement on Form S-8 - 400,000 shares of Tripos, Inc. </P>
<P>&#9;<U>Common Stock, $0.005 par value, and attached Preferred Stock Purchase Rights</P>
</U><P>Ladies and Gentlemen:</P>
<P>With reference to the Registration Statement on Form S-8 (the "Registration Statement") to be filed by Tripos, Inc., a Utah corporation (the "Company"), on March 29, 2002, with the Securities and Exchange Commission pursuant to the Securities Act of 1933, as amended, pertaining to the proposed issuance by the Company of up to 400,000 shares of the Company's common stock, $0.005 par value, and attached Preferred Stock Purchase Rights (collectively, the "Shares"), pursuant to the Tripos, Inc. 1994 Stock Option Plan (the "Plan"), we have examined such corporate records of the Company, such laws and such other information as we have deemed relevant, including the Company's Amended and Restated Articles of Incorporation, as amended, the Amended and Restated By-Laws and statements we have received from officers and representatives of the Company. In delivering this opinion, we have assumed the genuineness of all signatures, the authenticity of all documents submitted to us as originals, the conformity to the originals of all documents submitted to us as certified, photostatic or conformed copies, the authenticity of originals of all such latter documents, and the correctness of statements submitted to us by officers and representatives of the Company.</P>
<P>Based solely on the foregoing, we are of the opinion that the Shares to be issued by the Company pursuant to the Registration Statement have been duly authorized and, when issued by the Company in accordance with the Plan, will be duly and validly issued.</P>
<P>We consent to the filing of this opinion as an exhibit to the Registration Statement. We further consent to the filing of copies of this opinion with agencies of such states and other jurisdictions as you deem necessary in the course of complying with the laws of the states and jurisdictions regarding the sale and issuance of the Shares in accordance with the Registration Statement.</P>
<P>Very truly yours,</P>
<P>/s/Thompson Coburn LLP</P>
<P>&nbsp;</P>
<P>&nbsp;</P>
<P>&nbsp;</P>
<P>Exhibit 23.1</P>
<P ALIGN="CENTER">&nbsp;</P>
<P ALIGN="CENTER">&nbsp;</P>
<P ALIGN="CENTER">Consent of Independent Auditors</P>
<P ALIGN="JUSTIFY">We consent to the incorporation by reference in amendment No.1 to Registration No. 333-61829 pertaining to the 1994 Employee Stock Purchase Plan and the 1994 Stock Option Plan of our report dated February 5, 2002 (except for notes 16 and 18, as to which the date is February 8, 2002) with respect to the consolidated financial statements of Tripos, Inc. incorporated by reference in its Annual Report (Form 10-K) for the year ended December 31, 2001 and the related financial statement schedule included therein, filed with the Securities and Exchange Commission.</P>
<P ALIGN="JUSTIFY">&nbsp;</P>
<P ALIGN="JUSTIFY">/s/ Ernst &amp; Young LLP</P>
<P ALIGN="JUSTIFY">St. Louis, Missouri</P>
<P ALIGN="JUSTIFY">March 25, 2002</P></BODY>
</HTML>
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s-8 plan changes 2000
As Filed With the Securities and Exchange Commission on March 29, 2002
Registration No.
333-61829
UNITED STATES
SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
_______________________
AMENDMENT NO. 1
TO
FORM S-8
Registration Statement Under
The Securities Act of 1933
________________________
TRIPOS, INC.
(Exact name of registrant as specified in its charter)
Utah
43-1454986
(State or other jurisdiction of
(I.R.S. Employer
incorporation or organization)
1699 South Hanley Road
Identification No.)
St. Louis, Missouri 63144
(Address of Principal Executive Offices)
_________________________
TRIPOS, INC. 1994 EMPLOYEE STOCK PURCHASE PLAN
and
TRIPOS, INC. 1994 STOCK OPTION PLAN
(Full title of the plans)
JOHN D. YINGLING
Vice President and Chief Accounting Officer
Tripos, Inc.
1699 South Hanley Road
St. Louis, Missouri 63144
(Name and address of agent for service)
Telephone number, including area code, of agent for service:
(314) 647-1099
________________________
Copy to:
ROBERT M. LAROSE, ESQ.
Thompson Coburn LLP
One Firstar Plaza
St. Louis, Missouri 63101
(314) 552-6000
CALCULATION OF REGISTRATION FEE
Title of each class of securities to be registered
Amount to be registered
(2)
Proposed maximum offering price per unit
(3)
Proposed maximum aggregate offering price
(3)
Amount of registration fee
Common Stock, $.005 par value
(1)
400,000
$23.92
$9,568,000
$880.26
(1)	Includes one attached preferred stock purchase right per share.
(2)	The shares being registered hereby are reserved for issuance pursuant to the Tripos, Inc. 1994 Stock Option Plan.
(3)	Estimated solely for purposes of computing the Registration Fee pursuant to the provisions of Rule 457(h), based upon a price of $23.92 per share, being the average of the high and low transaction prices of the Registrant's common stock per share as reported on the Nasdaq National Market on March 26, 2002.
TRIPOS, INC.
1994 EMPLOYEE STOCK PURCHASE PLAN
and
TRIPOS, INC.
1994 STOCK OPTION PLAN
EXPLANATORY NOTE
This Amendment No. 1 to Registration Statement on Form S-8 is being filed by Tripos, Inc. in connection with the registration of an additional 400,000 shares of common stock, $.005 par value per share, to be issued pursuant to the Tripos, Inc. 1994 Stock Option Plan. The contents of the Registration Statement on Form S-8 (Reg. No. 333-61829) filed by Tripos, Inc. with the Securities and Exchange Commission on August 19, 1998, other than Item 5, are incorporated herein by reference.
Item 5. 	Not Applicable.
Item 8.
Exhibits
.
See Exhibit Index located at page 5 hereof.
SIGNATURES
Pursuant to the requirements of the Securities Act of 1933, the Registrant certifies that it has reasonable grounds to believe that it meets all of the requirements for filing on Form S-8 and has duly caused this Amendment No. 1 to Registration Statement (File No. 333-61829) to be signed on its behalf by the undersigned, thereunto duly authorized, in the County of St. Louis, State of Missouri, on the 29
th
day of March 2002.
TRIPOS, INC.
By: ___________________________
John P. McAlister, III
President and Chief Executive Officer
Pursuant to the requirements of the Securities Act of 1933, this Amendment No. 1 to Registration Statement has been signed by the following persons in the capacities and on the dates indicated.
Signature
Title
Date
_______________________
President, Chief Executive
March 29, 2002
John P. McAlister, III
Officer and Director
Principal Executive Officer
_______________________
Senior Vice President, Chief
March 29, 2002
James Rubin
Financial Officer and Secretary
Principal Financial Officer
_______________________
Vice President, Chief Accounting
March 29, 2002
John D. Yingling
Officer and Assistant Secretary
Principal Accounting Officer
_________*_____________
Chairman of the Board
March 29, 2002
Ralph S. Lobdell
of Directors
_________*_____________
Director
March 29, 2002
Gary Meredith
_________*_____________
Director
March 29, 2002
Stewart Carrell
_________*_____________
Director
March 29, 2002
Ferid Murad
_________*_____________
Director
March 29, 2002
Alfred Alberts
*By__________________________
John P. McAlister, III
Attorney-in-fact
John P. McAlister, III, by signing his name hereto, does sign this document on behalf of the individuals named above, pursuant to a power of attorney duly executed by such individuals, previously filed as Exhibit 24 to the Registration Statement on Form S-8 filed on August 19, 1998.
EXHIBIT INDEX
Exhibit No.
4.1	Amended and Restated Articles of Incorporation, dated January 26, 1996, incorporated by reference to the Registrant's Annual Report on Form 10-K for the fiscal year ended December 31, 1995.
4.2	Articles of Amendment to the Articles of Incorporation, dated February 4, 2000, incorporated by reference to Exhibit 3.3 to the Registrant's Annual Report on Form 10-K for the fiscal year ended December 31, 2000.
4.3	Amended and Restated Bylaws, incorporated by reference to the Registrant's Registration Statement on Form 10 dated May 27, 1994.
4.4	Investor's Rights Agreement, dated February 4, 2000, between LION bioscience AG and Tripos, Inc., incorporated by reference to Exhibit 4.1 to the Registrant's Annual Report on Form 10-K for the fiscal year ended December 31, 1999.
4.5	Rights Agreement, dated January 26, 1996, between Tripos, Inc. and Boatmen's Trust Company, as Rights Agent, incorporated by reference to the Registrant's Annual Report on Form 10-K for the fiscal year ended December 31, 1995.
5.1	Opinion of Thompson Coburn LLP as to the legality of the securities being registered.*
23.1	Consent of Ernst & Young LLP.*
23.2	Consent of Thompson Coburn LLP (included in Exhibit 5.1).
24.1	Power of Attorney.**
________________
*  Filed herewith
** Previously filed
Exhibit 5.1
March 29, 2002
Tripos, Inc.
1699 South Hanley Road
St. Louis, Missouri 63144
Re:	Registration Statement on Form S-8 - 400,000 shares of Tripos, Inc.
Common Stock, $0.005 par value, and attached Preferred Stock Purchase Rights
Ladies and Gentlemen:
With reference to the Registration Statement on Form S-8 (the "Registration Statement") to be filed by Tripos, Inc., a Utah corporation (the "Company"), on March 29, 2002, with the Securities and Exchange Commission pursuant to the Securities Act of 1933, as amended, pertaining to the proposed issuance by the Company of up to 400,000 shares of the Company's common stock, $0.005 par value, and attached Preferred Stock Purchase Rights (collectively, the "Shares"), pursuant to the Tripos, Inc. 1994 Stock Option Plan (the "Plan"), we have examined such corporate records of the Company, such laws and such other information as we have deemed relevant, including the Company's Amended and Restated Articles of Incorporation, as amended, the Amended and Restated By-Laws and statements we have received from officers and representatives of the Company. In delivering this opinion, we have assumed the genuineness of all signatures, the authenticity of all documents submitted to us as originals, the conformity to the originals of all documents submitted to us as certified, photostatic or conformed copies, the authenticity of originals of all such latter documents, and the correctness of statements submitted to us by officers and representatives of the Company.
Based solely on the foregoing, we are of the opinion that the Shares to be issued by the Company pursuant to the Registration Statement have been duly authorized and, when issued by the Company in accordance with the Plan, will be duly and validly issued.
We consent to the filing of this opinion as an exhibit to the Registration Statement. We further consent to the filing of copies of this opinion with agencies of such states and other jurisdictions as you deem necessary in the course of complying with the laws of the states and jurisdictions regarding the sale and issuance of the Shares in accordance with the Registration Statement.
Very truly yours,
/s/Thompson Coburn LLP
Exhibit 23.1
Consent of Independent Auditors
We consent to the incorporation by reference in amendment No.1 to Registration No. 333-61829 pertaining to the 1994 Employee Stock Purchase Plan and the 1994 Stock Option Plan of our report dated February 5, 2002 (except for notes 16 and 18, as to which the date is February 8, 2002) with respect to the consolidated financial statements of Tripos, Inc. incorporated by reference in its Annual Report (Form 10-K) for the year ended December 31, 2001 and the related financial statement schedule included therein, filed with the Securities and Exchange Commission.
/s/ Ernst & Young LLP
St. Louis, Missouri
March 25, 2002