As filed with the Securities and Exchange Commission on September 26, 1997
                           Registration No. 333-______


                       SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549
                                 --------------

                                    FORM S-8
                             REGISTRATION STATEMENT
                                      UNDER
                           THE SECURITIES ACT OF 1933


                         BioSpecifics Technologies Corp.
               (Exact Name of issuer as specified in its charter)

            Delaware                                          11-3054851
(State or Other Jurisdiction of                            (I.R.S. Employer
 incorporation or organization)                           Identification No.)


                                35 Wilbur Street
                            Lynbrook, New York 11563
                                 (516) 593-7000
                    (Address of principal executive offices)
                                 --------------

                         BIOSPECIFICS TECHNOLOGIES CORP.
                             1997 STOCK OPTION PLAN
                            (Full title of the plan)
                                 --------------

                            ALBERT HORCHER, Secretary
                         BioSpecifics Technologies Corp.
                                35 Wilbur Street
                            Lynbrook, New York 11563
                     (Name and address of agent for service)

   Telephone number, including area code, of agent for service: (516) 593-7000
<TABLE>
<CAPTION>

                         CALCULATION OF REGISTRATION FEE
================================================================================================================================
                                                           Proposed                  Proposed
                                                            Maximum                   Maximum                 Amount of
    Title of Shares            Amount to be             Offering Price               Aggregate               Registration
   to be Registered             Registered               Per Share(1)            Offering Price(1)               Fee
--------------------------------------------------------------------------------------------------------------------------------
<S>                           <C>                      <C>                      <C>                        <C>
Common Stock (par
value $.001 per              
share).........................500,000 shares           $4.625                   $2,312,500                 $701
================================================================================================================================

(1)       Estimated solely for the purpose of calculating the registration fee pursuant to Rule 457 of the Securities Act of 1933,
using the average of the high and low sale prices reported on the National  Association of Securities Dealers Automated  Quotation
System on September 22, 1997.

          There are also registered  hereunder such additional  indeterminate number of shares as may be issued as a result of the
antidilution provisions of the BioSpecifics Technologies Corp. 1997 Stock Option Plan.
</TABLE>

<PAGE>



                                     PART I

Item 1.   PLAN INFORMATION.

          Not included pursuant to Form S-8 instructions.

Item 2.   REGISTRANT INFORMATION AND EMPLOYEE PLAN ANNUAL INFORMATION.

          Not included pursuant to Form S-8 instructions.

                                     PART II

Item 3.   INCORPORATION OF CERTAIN DOCUMENTS BY REFERENCE.

          BioSpecifics  Technologies  Corp. (the "Company") hereby  incorporates
herein by reference the following documents:

          (1)  The  Company's  annual  report on Form  10-KSB for the year ended
               January 31, 1997;

          (2)  All  reports  filed  pursuant  to  Section  13(a) or 15(d) of the
               Securities Exchange Act of 1934, as amended (the "Exchange Act"),
               on or after January 31, 1997, including the Company's Form 10-QSB
               for the period ended July 31, 1997; and

          (3)  The  description of the Company's  Common Stock  contained in the
               Company's  Registration  Statement  on Form  8-A  filed  with the
               Securities and Exchange Commission (the "Commission") on February
               21, 1992,  including any amendments thereto and any reports filed
               for the purpose of updating such description  (the  "Registration
               Statement").

          In addition,  all documents filed by the Company  pursuant to Sections
13(a),  13(c),  14 and 15(d) of the Exchange Act  subsequent to the date of this
registration  statement  and prior to the filing of a  post-effective  amendment
which  indicates  that all  securities  offered  herein  have been sold or which
deregisters  all  securities  then  remaining  unsold  shall  be  deemed  to  be
incorporated  herein by  reference  and to be a part hereof from the  respective
date of filing of each such document.

Item 4.   DESCRIPTION OF SECURITIES.

          Not applicable.

Item 5.   INTERESTS OF NAMED EXPERTS AND COUNSEL.

          Not applicable.

Item 6.   INDEMNIFICATION OF DIRECTORS AND OFFICERS.

          Section 145 of the Delaware General Corporation Law provides generally
that a person sued as a director,  officer,  employee or agent of a  corporation


                                        2

<PAGE>


may be  indemnified  by the  corporation  in  nonderivative  suits for  expenses
(including attorneys' fees), judgments,  fines and amounts paid in settlement if
such person acted in good faith and in a manner he or she reasonably believed to
be in the best interest of the corporation.  In the case of criminal actions and
proceedings,  such person must also have had no reasonable  cause to believe his
or her conduct was  unlawful.  Indemnification  of  expenses  is  authorized  in
stockholder  derivative suits where such person in good faith and in a manner he
or she reasonably believed to be in the best interests of the corporation and so
long as he had not  been  found  liable  for  negligence  or  misconduct  in the
performance of his duty to the corporation.  Even in this latter  instance,  the
court  may  determine  that  in view of all the  circumstances  such  person  is
entitled to indemnification for such expenses as the court deems proper.

          The  Company's   By-laws  authorize   indemnification   of  directors,
officers,  employees and agents on the terms and conditions set forth in Section
145 of the Delaware General Corporation Law.

          Insofar  as   indemnification   for  liabilities   arising  under  the
Securities  Act of 1933, as amended (the "Act"),  may be permitted to directors,
officers  and  controlling  persons of the  Company  pursuant  to the  foregoing
provisions,  or  otherwise,  the Company has been advised that in the opinion of
the Commission such indemnification is against public policy as expressed in the
Act  and  is,  therefore,   unenforceable.   In  the  event  that  a  claim  for
indemnification  against such liabilities (other than the payment by the Company
of expenses incurred or paid by a director, officer or controlling person of the
Company in the successful defense of any action, suit or proceeding) is asserted
by  such  director,  officer  or  controlling  person  in  connection  with  the
securities  being  registered,  the Company  will,  unless in the opinion of its
counsel the matter has been settled by controlling precedent,  submit to a court
of appropriate  jurisdiction the question whether such  indemnification by it is
against  public policy as expressed in the Act and will be governed by the final
adjudication of such issue.

Item 7.   EXEMPTION FROM REGISTRATION CLAIMED.

          Not applicable.

Item 8.  EXHIBITS.

Exhibit No.                             Exhibit
-----------                             -------

     3.1                 Certificate    of   Amendment   of    Certificate    of
                         Incorporation of the Company (incorporated by reference
                         from the Company's Registration Statement on Form S-18,
                         filed  with  the   Commission   on  November  14,  1991
                         (Registration No.  33-40850-NY (the "1991  Registration
                         Statement")).

     3.2                 By-Laws of the  Company,  as amended  (incorporated  by
                         reference from the 1991 Registration Statement).

     4.1                 BioSpecifics Technologies Corp. 1997 Stock Option Plan.

     23.1                Consent   of  KPMG  Peat   Marwick   LLP,   independent
                         accountants.

     24.1                Power of Attorney  (included on signature  page of this
                         Form S-8).


                                        3

<PAGE>



Item 9.   UNDERTAKINGS.

          (a)  The undersigned hereby undertakes:

          (1)  to file, during  any  period  in which  offers or sales are being
made, a post-effective amendment to this registration statement:

               (i)  To include any  prospectus  required by Section  10(a)(3) of
               the Act;

               (ii) To reflect  in the  prospectus  any facts or events  arising
               after the effective date of this  registration  statement (or the
               most recent post-effective amendment thereof) which, individually
               or in  the  aggregate,  represent  a  fundamental  change  in the
               information set forth in this registration statement; and

               (iii)To include  any  material  information  with  respect to the
               plan  of   distribution   not   previously   disclosed   in  this
               registration statement or any material change to such information
               in this registration statement;

provided,  however, that paragraphs (a)(1)(i) and (a)(1)(ii) do not apply if the
--------   -------
information to be included in a post-effective  amendment by those paragraphs is
contained  in periodic  reports  filed by the Company  pursuant to Section 13 or
Section  15(d) of the  Exchange Act that are  incorporated  by reference in this
registration statement.

          (2) that, for the purpose of determining  any liability under the Act,
each such  post-effective  amendment  shall be  deemed to be a new  registration
statement relating to the securities  offered therein,  and the offering of such
securities  at that time shall be deemed to be the  initial  bona fide  offering
thereof; and

          (3) to remove from registration by means of a post-effective amendment
any of the securities being registered which remain unsold at the termination of
the offering.

          (b)  The undersigned  Company hereby  undertakes that, for purposes of
               determining  any  liability  under  the Act,  each  filing of the
               Company's  Annual  Report  pursuant  to Section  13(a) or Section
               15(d) of the Exchange Act (and, where applicable,  each filing of
               an employee  benefit  plan's  Annual  Report  pursuant to Section
               15(d) of the Exchange Act) that is  incorporated  by reference in
               this  registration   statement  shall  be  deemed  to  be  a  new
               registration   statement   relating  to  the  securities  offered
               therein,  and the offering of such  securities at that time shall
               be deemed to be the initial bona fide offering thereof.

          (c)  Insofar as indemnification  for liabilities arising under the Act
               may be permitted to directors,  officers and controlling  persons
               of  the  Company  pursuant  to  the  foregoing   provisions,   or
               otherwise,  the Company has been  advised  that in the opinion of
               the Commission such  indemnification  is against public policy as
               expressed  in the Act and is,  therefore,  unenforceable.  In the
               event that a claim for  indemnification  against such liabilities
               (other than the  payment by the  Company of expenses  incurred or
               paid by a director,  officer or controlling person of the Company
               in the successful  defense of any action,  suit or proceeding) is


                                        4

<PAGE>


               asserted  by such  director,  officer  or  controlling  person in
               connection  with the  securities  being  registered,  the Company
               will,  unless in the  opinion of its  counsel the matter has been
               settled  by   controlling   precedent,   submit  to  a  court  of
               appropriate    jurisdiction    the    question    whether    such
               indemnification  by it is against  public  policy as expressed in
               the Act and will be  governed by the final  adjudication  of such
               issue.


                                        5

<PAGE>




                                   SIGNATURES

          Pursuant  to the  requirements  of the  Securities  Act of  1933,  the
Registrant  has duly  caused  this  Registration  Statement  to be signed on its
behalf by the undersigned,  thereunto duly authorized,  in the City of Lynbrook,
State of New York on this day of September 26, 1997.

                                        BIOSPECIFICS TECHNOLOGIES CORP.


                                        /S/ EDWIN H. WEGMAN
                                        ---------------------------------------
                                        By: Edwin H. Wegman
                                            Chairman and President



                                POWER OF ATTORNEY

          Each  of  the  undersigned  officers  and  directors  of  BioSpecifics
Technologies Corp. hereby severally  constitutes and appoints Albert Horcher and
Thomas  L.  Wegman,  and each of them  severally,  as  attorney-in-fact  for the
undersigned, in any and all capacities, with full power of substitution, to sign
this Registration  Statement and any amendments to this  Registration  Statement
(including  post-effective  amendments),  and to file  the  same  with  exhibits
thereto and other  documents in connection  therewith,  with the  Securities and
Exchange  Commission,   granting  unto  said  attorney-in-fact  full  power  and
authority to do and perform  each and every act  requisite  and  necessary to be
done in and about the  premises,  as fully to all intents and  purposes as he or
she might or could do in person,  hereby  ratifying and confirming all that said
attorney-in-fact may lawfully do or cause to be done by virtue hereof.

          Pursuant  to the  requirements  of the  Securities  Act of 1933,  this
Registration  Statement  has been signed below by the  following  persons in the
capacities and on the dates indicated.

<TABLE>
<CAPTION>
<S>                                         <C>                                                       <C>

/S/ EDWIN H. WEGMAN                          Chairman of the Board, President and                      September 26, 1997
-----------------------                      Director (Principal Executive Officer)  
  Edwin H. Wegman                         

/S/ ALBERT HORCHER                           Secretary and Treasurer, Principal                        September 26, 1997
-----------------------                      Financial and Chief Accounting Officer
  Albert Horcher                

/S/ THOMAS L. WEGMAN                         Executive Vice President and Director                     September 26, 1997
-----------------------
  Thomas L. Wegman

/S/ PAUL A. GITMAN                           Director                                                  September 26, 1997
-----------------------
  Paul A. Gitman, M.D.

/S/ HENRY MORGAN                             Director                                                  September 26, 1997
-----------------------
  Henry Morgan

                                             Director                                                  September 26, 1997
-----------------------
  Sherman C. Vogel

/S/ RAINER FRIEDEL                           Director                                                  September 26, 1997
-----------------------
  Rainer Friedel

</TABLE>

<PAGE>



                                INDEX TO EXHIBITS

          The  following  is a complete  list of exhibits  filed as part of this
registration statement:

Exhibit No.                                       Exhibit
-----------                                       -------

     3.1                 Certificate    of   Amendment   of    Certificate    of
                         Incorporation of the Company (incorporated by reference
                         from the Company's Registration Statement on Form S-18,
                         filed  with  the   Commission   on  November  14,  1991
                         (Registration No.  33-40850-NY (the "1991  Registration
                         Statement")).

     3.2                 By-Laws of the  Company,  as amended  (incorporated  by
                         reference from the 1991 Registration Statement).

     4.1                 BioSpecifics Technologies Corp. 1997 Stock Option Plan.

     23.1                Consent   of  KPMG  Peat   Marwick   LLP,   independent
                         accountants.

     24.1                Power of Attorney  (included on signature  page of this
                         Form S-8).
[{"type": "S-8", "sequence": "1", "description": "FORM S-8 RE BIOSPECIFICS TECHNOLOGIES CORP.", "secsgml_size_bytes": 17945}]
{"company-data": {"conformed-name": "BIOSPECIFICS TECHNOLOGIES CORP", "cik": "0000875622", "assigned-sic": "2834", "irs-number": "113054851", "state-of-incorporation": "DE", "fiscal-year-end": "0131"}, "filing-values": {"form-type": "S-8", "act": "33", "file-number": "333-36485", "film-number": "97686275"}, "business-address": {"street1": "35 WILBUR ST", "city": "LYNBROOK", "state": "NY", "zip": "11563", "phone": "5165937000"}, "mail-address": {"street1": "35 WILBUR STREET", "city": "LYNBROOK", "state": "NY", "zip": "11563"}}
As filed with the Securities and Exchange Commission on September 26, 1997
                           Registration No. 333-______

                       SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549
                                 --------------

                                    FORM S-8
                             REGISTRATION STATEMENT
                                      UNDER
                           THE SECURITIES ACT OF 1933

                         BioSpecifics Technologies Corp.
               (Exact Name of issuer as specified in its charter)

            Delaware                                          11-3054851
(State or Other Jurisdiction of                            (I.R.S. Employer
 incorporation or organization)                           Identification No.)

                                35 Wilbur Street
                            Lynbrook, New York 11563
                                 (516) 593-7000
                    (Address of principal executive offices)
                                 --------------

                         BIOSPECIFICS TECHNOLOGIES CORP.
                             1997 STOCK OPTION PLAN
                            (Full title of the plan)
                                 --------------

                            ALBERT HORCHER, Secretary
                         BioSpecifics Technologies Corp.
                                35 Wilbur Street
                            Lynbrook, New York 11563
                     (Name and address of agent for service)

   Telephone number, including area code, of agent for service: (516) 593-7000
CALCULATION OF REGISTRATION FEE
================================================================================================================================
                                                           Proposed                  Proposed
                                                            Maximum                   Maximum                 Amount of
    Title of Shares            Amount to be             Offering Price               Aggregate               Registration
   to be Registered             Registered               Per Share(1)            Offering Price(1)               Fee
--------------------------------------------------------------------------------------------------------------------------------
Common Stock (par
value $.001 per              
share).........................500,000 shares           $4.625                   $2,312,500                 $701
================================================================================================================================

(1)       Estimated solely for the purpose of calculating the registration fee pursuant to Rule 457 of the Securities Act of 1933,
using the average of the high and low sale prices reported on the National  Association of Securities Dealers Automated  Quotation
System on September 22, 1997.

          There are also registered  hereunder such additional  indeterminate number of shares as may be issued as a result of the
antidilution provisions of the BioSpecifics Technologies Corp. 1997 Stock Option Plan.
PART I

Item 1.   PLAN INFORMATION.

          Not included pursuant to Form S-8 instructions.

Item 2.   REGISTRANT INFORMATION AND EMPLOYEE PLAN ANNUAL INFORMATION.

          Not included pursuant to Form S-8 instructions.

                                     PART II

Item 3.   INCORPORATION OF CERTAIN DOCUMENTS BY REFERENCE.

          BioSpecifics  Technologies  Corp. (the "Company") hereby  incorporates
herein by reference the following documents:

          (1)  The  Company's  annual  report on Form  10-KSB for the year ended
               January 31, 1997;

          (2)  All  reports  filed  pursuant  to  Section  13(a) or 15(d) of the
               Securities Exchange Act of 1934, as amended (the "Exchange Act"),
               on or after January 31, 1997, including the Company's Form 10-QSB
               for the period ended July 31, 1997; and

          (3)  The  description of the Company's  Common Stock  contained in the
               Company's  Registration  Statement  on Form  8-A  filed  with the
               Securities and Exchange Commission (the "Commission") on February
               21, 1992,  including any amendments thereto and any reports filed
               for the purpose of updating such description  (the  "Registration
               Statement").

          In addition,  all documents filed by the Company  pursuant to Sections
13(a),  13(c),  14 and 15(d) of the Exchange Act  subsequent to the date of this
registration  statement  and prior to the filing of a  post-effective  amendment
which  indicates  that all  securities  offered  herein  have been sold or which
deregisters  all  securities  then  remaining  unsold  shall  be  deemed  to  be
incorporated  herein by  reference  and to be a part hereof from the  respective
date of filing of each such document.

Item 4.   DESCRIPTION OF SECURITIES.

          Not applicable.

Item 5.   INTERESTS OF NAMED EXPERTS AND COUNSEL.

          Not applicable.

Item 6.   INDEMNIFICATION OF DIRECTORS AND OFFICERS.

          Section 145 of the Delaware General Corporation Law provides generally
that a person sued as a director,  officer,  employee or agent of a  corporation

                                        2
may be  indemnified  by the  corporation  in  nonderivative  suits for  expenses
(including attorneys' fees), judgments,  fines and amounts paid in settlement if
such person acted in good faith and in a manner he or she reasonably believed to
be in the best interest of the corporation.  In the case of criminal actions and
proceedings,  such person must also have had no reasonable  cause to believe his
or her conduct was  unlawful.  Indemnification  of  expenses  is  authorized  in
stockholder  derivative suits where such person in good faith and in a manner he
or she reasonably believed to be in the best interests of the corporation and so
long as he had not  been  found  liable  for  negligence  or  misconduct  in the
performance of his duty to the corporation.  Even in this latter  instance,  the
court  may  determine  that  in view of all the  circumstances  such  person  is
entitled to indemnification for such expenses as the court deems proper.

          The  Company's   By-laws  authorize   indemnification   of  directors,
officers,  employees and agents on the terms and conditions set forth in Section
145 of the Delaware General Corporation Law.

          Insofar  as   indemnification   for  liabilities   arising  under  the
Securities  Act of 1933, as amended (the "Act"),  may be permitted to directors,
officers  and  controlling  persons of the  Company  pursuant  to the  foregoing
provisions,  or  otherwise,  the Company has been advised that in the opinion of
the Commission such indemnification is against public policy as expressed in the
Act  and  is,  therefore,   unenforceable.   In  the  event  that  a  claim  for
indemnification  against such liabilities (other than the payment by the Company
of expenses incurred or paid by a director, officer or controlling person of the
Company in the successful defense of any action, suit or proceeding) is asserted
by  such  director,  officer  or  controlling  person  in  connection  with  the
securities  being  registered,  the Company  will,  unless in the opinion of its
counsel the matter has been settled by controlling precedent,  submit to a court
of appropriate  jurisdiction the question whether such  indemnification by it is
against  public policy as expressed in the Act and will be governed by the final
adjudication of such issue.

Item 7.   EXEMPTION FROM REGISTRATION CLAIMED.

          Not applicable.

Item 8.  EXHIBITS.

Exhibit No.                             Exhibit
-----------                             -------

     3.1                 Certificate    of   Amendment   of    Certificate    of
                         Incorporation of the Company (incorporated by reference
                         from the Company's Registration Statement on Form S-18,
                         filed  with  the   Commission   on  November  14,  1991
                         (Registration No.  33-40850-NY (the "1991  Registration
                         Statement")).

     3.2                 By-Laws of the  Company,  as amended  (incorporated  by
                         reference from the 1991 Registration Statement).

     4.1                 BioSpecifics Technologies Corp. 1997 Stock Option Plan.

     23.1                Consent   of  KPMG  Peat   Marwick   LLP,   independent
                         accountants.

     24.1                Power of Attorney  (included on signature  page of this
                         Form S-8).

                                        3
Item 9.   UNDERTAKINGS.

          (a)  The undersigned hereby undertakes:

          (1)  to file, during  any  period  in which  offers or sales are being
made, a post-effective amendment to this registration statement:

               (i)  To include any  prospectus  required by Section  10(a)(3) of
               the Act;

               (ii) To reflect  in the  prospectus  any facts or events  arising
               after the effective date of this  registration  statement (or the
               most recent post-effective amendment thereof) which, individually
               or in  the  aggregate,  represent  a  fundamental  change  in the
               information set forth in this registration statement; and

               (iii)To include  any  material  information  with  respect to the
               plan  of   distribution   not   previously   disclosed   in  this
               registration statement or any material change to such information
               in this registration statement;

provided,  however, that paragraphs (a)(1)(i) and (a)(1)(ii) do not apply if the
--------   -------
information to be included in a post-effective  amendment by those paragraphs is
contained  in periodic  reports  filed by the Company  pursuant to Section 13 or
Section  15(d) of the  Exchange Act that are  incorporated  by reference in this
registration statement.

          (2) that, for the purpose of determining  any liability under the Act,
each such  post-effective  amendment  shall be  deemed to be a new  registration
statement relating to the securities  offered therein,  and the offering of such
securities  at that time shall be deemed to be the  initial  bona fide  offering
thereof; and

          (3) to remove from registration by means of a post-effective amendment
any of the securities being registered which remain unsold at the termination of
the offering.

          (b)  The undersigned  Company hereby  undertakes that, for purposes of
               determining  any  liability  under  the Act,  each  filing of the
               Company's  Annual  Report  pursuant  to Section  13(a) or Section
               15(d) of the Exchange Act (and, where applicable,  each filing of
               an employee  benefit  plan's  Annual  Report  pursuant to Section
               15(d) of the Exchange Act) that is  incorporated  by reference in
               this  registration   statement  shall  be  deemed  to  be  a  new
               registration   statement   relating  to  the  securities  offered
               therein,  and the offering of such  securities at that time shall
               be deemed to be the initial bona fide offering thereof.

          (c)  Insofar as indemnification  for liabilities arising under the Act
               may be permitted to directors,  officers and controlling  persons
               of  the  Company  pursuant  to  the  foregoing   provisions,   or
               otherwise,  the Company has been  advised  that in the opinion of
               the Commission such  indemnification  is against public policy as
               expressed  in the Act and is,  therefore,  unenforceable.  In the
               event that a claim for  indemnification  against such liabilities
               (other than the  payment by the  Company of expenses  incurred or
               paid by a director,  officer or controlling person of the Company
               in the successful  defense of any action,  suit or proceeding) is

                                        4
asserted  by such  director,  officer  or  controlling  person in
               connection  with the  securities  being  registered,  the Company
               will,  unless in the  opinion of its  counsel the matter has been
               settled  by   controlling   precedent,   submit  to  a  court  of
               appropriate    jurisdiction    the    question    whether    such
               indemnification  by it is against  public  policy as expressed in
               the Act and will be  governed by the final  adjudication  of such
               issue.

                                        5
SIGNATURES

          Pursuant  to the  requirements  of the  Securities  Act of  1933,  the
Registrant  has duly  caused  this  Registration  Statement  to be signed on its
behalf by the undersigned,  thereunto duly authorized,  in the City of Lynbrook,
State of New York on this day of September 26, 1997.

                                        BIOSPECIFICS TECHNOLOGIES CORP.

                                        /S/ EDWIN H. WEGMAN
                                        ---------------------------------------
                                        By: Edwin H. Wegman
                                            Chairman and President

                                POWER OF ATTORNEY

          Each  of  the  undersigned  officers  and  directors  of  BioSpecifics
Technologies Corp. hereby severally  constitutes and appoints Albert Horcher and
Thomas  L.  Wegman,  and each of them  severally,  as  attorney-in-fact  for the
undersigned, in any and all capacities, with full power of substitution, to sign
this Registration  Statement and any amendments to this  Registration  Statement
(including  post-effective  amendments),  and to file  the  same  with  exhibits
thereto and other  documents in connection  therewith,  with the  Securities and
Exchange  Commission,   granting  unto  said  attorney-in-fact  full  power  and
authority to do and perform  each and every act  requisite  and  necessary to be
done in and about the  premises,  as fully to all intents and  purposes as he or
she might or could do in person,  hereby  ratifying and confirming all that said
attorney-in-fact may lawfully do or cause to be done by virtue hereof.

          Pursuant  to the  requirements  of the  Securities  Act of 1933,  this
Registration  Statement  has been signed below by the  following  persons in the
capacities and on the dates indicated.
/S/ EDWIN H. WEGMAN                          Chairman of the Board, President and                      September 26, 1997
-----------------------                      Director (Principal Executive Officer)  
  Edwin H. Wegman                         

/S/ ALBERT HORCHER                           Secretary and Treasurer, Principal                        September 26, 1997
-----------------------                      Financial and Chief Accounting Officer
  Albert Horcher                

/S/ THOMAS L. WEGMAN                         Executive Vice President and Director                     September 26, 1997
-----------------------
  Thomas L. Wegman

/S/ PAUL A. GITMAN                           Director                                                  September 26, 1997
-----------------------
  Paul A. Gitman, M.D.

/S/ HENRY MORGAN                             Director                                                  September 26, 1997
-----------------------
  Henry Morgan

                                             Director                                                  September 26, 1997
-----------------------
  Sherman C. Vogel

/S/ RAINER FRIEDEL                           Director                                                  September 26, 1997
-----------------------
  Rainer Friedel
INDEX TO EXHIBITS

          The  following  is a complete  list of exhibits  filed as part of this
registration statement:

Exhibit No.                                       Exhibit
-----------                                       -------

     3.1                 Certificate    of   Amendment   of    Certificate    of
                         Incorporation of the Company (incorporated by reference
                         from the Company's Registration Statement on Form S-18,
                         filed  with  the   Commission   on  November  14,  1991
                         (Registration No.  33-40850-NY (the "1991  Registration
                         Statement")).

     3.2                 By-Laws of the  Company,  as amended  (incorporated  by
                         reference from the 1991 Registration Statement).

     4.1                 BioSpecifics Technologies Corp. 1997 Stock Option Plan.

     23.1                Consent   of  KPMG  Peat   Marwick   LLP,   independent
                         accountants.

     24.1                Power of Attorney  (included on signature  page of this
                         Form S-8).