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<P ALIGN="CENTER"><FONT SIZE=2><B>As filed with the Securities and Exchange Commission on May&nbsp;9, 2001  </B></FONT></P>

<P ALIGN="RIGHT"><FONT SIZE=2><B> Registration No.&nbsp;333-_____  </B></FONT></P>

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<P ALIGN="CENTER"><FONT SIZE=5><B>SECURITIES AND EXCHANGE COMMISSION<BR>  </B></FONT><FONT SIZE=2><B>Washington, DC 20549  </B></FONT></P>

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<P ALIGN="CENTER"><FONT SIZE=5><B>FORM S-8<BR>  </B></FONT><FONT SIZE=2><B>REGISTRATION STATEMENT<BR>
UNDER<BR>
THE SECURITIES ACT OF 1933  </B></FONT></P>

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<P ALIGN="CENTER"><FONT SIZE=5><B>PHARMACOPEIA,&nbsp;INC.<BR>  </B></FONT><FONT SIZE=2>(Exact name of Registrant as specified in its charter) </FONT></P>

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<TD WIDTH="33%" ALIGN="CENTER"><FONT SIZE=2><B>Delaware<BR> </B></FONT><FONT SIZE=2>(State of Incorporation)</FONT></TD>
<TD WIDTH="33%" ALIGN="CENTER"><FONT SIZE=2><B>CN 5350<BR>
Princeton, New Jersey 08543-5350<BR> </B></FONT><FONT SIZE=2>(Address of principal executive offices) (Zip Code)</FONT></TD>
<TD WIDTH="33%" ALIGN="CENTER"><FONT SIZE=2><B>33-0557266<BR> </B></FONT><FONT SIZE=2>(I.R.S. Employer<BR>
Identification No.)</FONT></TD>
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<P ALIGN="CENTER"><FONT SIZE=5><B>PHARMACOPEIA, INC.<BR>
EMPLOYEE STOCK PURCHASE PLAN<BR>  </B></FONT><FONT SIZE=2>(Full Title of the Plan) </FONT></P>

<P ALIGN="CENTER"><FONT SIZE=2><B>Joseph A. Mollica, Ph.D.<BR>
Chairman of the Board, President and Chief Executive Officer<BR>
Pharmacopeia, Inc.<BR>
CN 5350<BR>
Princeton, New Jersey 08543-5350<BR>  </B></FONT><FONT SIZE=2>(name and address of agent for service) </FONT></P>

<P ALIGN="CENTER"><FONT SIZE=2><B>(609) 452-3600<BR>  </B></FONT><FONT SIZE=2>(Telephone number, including area code, of agent for service) </FONT></P>

<P ALIGN="CENTER"><FONT SIZE=2><B>COPY TO:<BR>  </B></FONT><FONT SIZE=2>James J. Marino, Esq.<BR>
Dechert<BR>
Princeton Pike Corporate Center<BR>
997 Lenox Drive, Building 3, Suite 210<BR>
Lawrenceville, New Jersey 08648<BR>
(609) 620-3200 </FONT></P>

<P ALIGN="CENTER"><FONT SIZE=2><B>CALCULATION OF REGISTRATION FEE  </B></FONT></P>

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<TD WIDTH="34%" VALIGN="BOTTOM"><FONT SIZE=1><B>Title of securities to be registered</B></FONT></TD>
<TD WIDTH="1%" VALIGN="BOTTOM"><FONT SIZE=1>&nbsp;</FONT></TD>
<TD WIDTH="17%" ALIGN="CENTER" VALIGN="BOTTOM"><FONT SIZE=1><B>Amount to be registered</B></FONT></TD>
<TD WIDTH="1%" VALIGN="BOTTOM"><FONT SIZE=1>&nbsp;</FONT></TD>
<TD WIDTH="14%" ALIGN="CENTER" VALIGN="BOTTOM"><FONT SIZE=1><B>Proposed maximum offering price per share(1)</B></FONT></TD>
<TD WIDTH="1%" VALIGN="BOTTOM"><FONT SIZE=1>&nbsp;</FONT></TD>
<TD WIDTH="16%" ALIGN="CENTER" VALIGN="BOTTOM"><FONT SIZE=1><B>Proposed maximum aggregate offering price(1)</B></FONT></TD>
<TD WIDTH="1%" VALIGN="BOTTOM"><FONT SIZE=1>&nbsp;</FONT></TD>
<TD WIDTH="14%" ALIGN="CENTER" VALIGN="BOTTOM"><FONT SIZE=1><B>Amount of registration fee</B></FONT></TD>
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<TD WIDTH="34%"><FONT SIZE=2>Common Stock, par value $0.0001 per share</FONT></TD>
<TD WIDTH="1%"><FONT SIZE=2>&nbsp;</FONT></TD>
<TD WIDTH="17%" ALIGN="CENTER"><FONT SIZE=2>500,000 shares</FONT></TD>
<TD WIDTH="1%"><FONT SIZE=2>&nbsp;</FONT></TD>
<TD WIDTH="14%" ALIGN="CENTER"><FONT SIZE=2>$17.93</FONT></TD>
<TD WIDTH="1%"><FONT SIZE=2>&nbsp;</FONT></TD>
<TD WIDTH="16%" ALIGN="CENTER"><FONT SIZE=2>$8,965,000.00</FONT></TD>
<TD WIDTH="1%"><FONT SIZE=2>&nbsp;</FONT></TD>
<TD WIDTH="14%" ALIGN="CENTER"><FONT SIZE=2>$2,241.25</FONT></TD>
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<DT><FONT SIZE=2>(1)</FONT></DT><DD><FONT SIZE=2>Estimated
solely for the purpose of calculating the registration fee in accordance with paragraph&nbsp;(h) of Rule&nbsp;457 of the Securities Act of 1933, as amended, on the
basis of the average of the high and low sales price for the Common Stock of Pharmacopeia as reported on the Nasdaq National Market on May&nbsp;3, 2001. </FONT></DD></DL>
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<BR></FONT><FONT SIZE=2><B>PART I<BR>  INFORMATION REQUIRED IN THE SECTION 10(a) PROSPECTUS    <BR>  </B></FONT></P>

<P><FONT SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;The documents containing information specified in Part&nbsp;I of Form&nbsp;S-8 will be sent or given to employees as specified by
Rule&nbsp;428(b)(1) of the Securities Act of 1933, as amended (the "Securities Act"). 250,000 shares of Pharmacopeia Common Stock were registered on Form&nbsp;S-8 with respect to the
Pharmacopeia,&nbsp;Inc. Employee Stock Purchase Plan on December&nbsp;13, 1995. </FONT></P>

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<BR></FONT><FONT SIZE=2><B>PART II<BR>  INFORMATION REQUIRED IN THE REGISTRATION STATEMENT    <BR>  </B></FONT></P>

<P><FONT SIZE=2><B>Item 3. Incorporation of Documents by Reference.  </B></FONT></P>

<P><FONT SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;The following documents of Pharmacopeia,&nbsp;Inc. (the "Registrant") filed or to be filed with the Securities and Exchange Commission (the "Commission") are
incorporated by reference in this Registration Statement as of their respective dates: </FONT></P>

<DL compact>
<DT><FONT SIZE=2>(a)</FONT></DT><DD><FONT SIZE=2>The
Registrant's Annual Report on Form&nbsp;10-K for the year ended December&nbsp;31, 2000, which contains audited financial statements for the Registrant's fiscal
year ended December&nbsp;31, 2000, and all other reports filed by the Registrant with the Commission since December&nbsp;31, 2000 pursuant to Section&nbsp;13(a) or 15(d) of the Securities
Exchange Act of 1934, as amended (the "Exchange Act").
<BR><BR></FONT></DD><DT><FONT SIZE=2>(b)</FONT></DT><DD><FONT SIZE=2>The
description of the Registrant's Common Stock set forth in the Registrant's Registration Statement filed pursuant to Section&nbsp;12 of the Exchange Act and any amendments or
reports filed for the purpose of updating such description.
<BR><BR></FONT></DD><DT><FONT SIZE=2>(c)</FONT></DT><DD><FONT SIZE=2>All
reports and documents filed by the Registrant with the Commission pursuant to Sections 13(a), 13(c), 14 and 15(d) of the Exchange Act subsequent to the date of this Registration
Statement and prior to the filing of a post-effective amendment which indicates that all securities offered hereby have been sold or which deregisters all such securities then remaining to
be sold. </FONT></DD></DL>

<P><FONT SIZE=2><B>Item 4. Description of Securities.  </B></FONT></P>

<P><FONT SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;Not applicable. </FONT></P>

<P><FONT SIZE=2><B>Item 5. Interests of Named Experts and Counsel.  </B></FONT></P>

<P><FONT SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;The validity of the Registrant's Common Stock offered hereby will be passed upon by the law firm of Dechert. James J. Marino, a partner of Dechert, is a
director of the Registrant and owns 1,200 shares of the Registrant's Common Stock. </FONT></P>

<P><FONT SIZE=2><B>Item 6. Indemnification of Directors and Officers.  </B></FONT></P>

<P><FONT SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;Section&nbsp;145 ("Section&nbsp;145") of the Delaware General Corporation Law (the "DGCL") provides generally and in pertinent part that a
Delaware corporation may indemnify its directors, officers, employees and agents against expenses (including attorneys' fees), judgments, fines and settlements actually and reasonably incurred by them
in connection with any civil, criminal, administrative or investigative action, suit or proceeding (except actions by or in the right of the corporation), if, they acted in good faith and in a manner
they reasonably believed to be in, or not opposed to, the best interests of the corporation, and, with respect to any criminal suit or proceeding, they had no reasonable cause to believe their conduct
was unlawful. Section&nbsp;145 further provides that, in connection with the defense or settlement of any action by or in the right of the corporation, a Delaware corporation may indemnify its
directors, officers, employees and agents against expenses actually and reasonably incurred by them if they acted in good faith and in a manner they reasonably believed to be in, or not opposed to,
the best interests of the corporation, except that no indemnification shall be </FONT></P>

<P ALIGN="CENTER"><FONT SIZE=2>1</FONT></P>

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made in respect of any claim, issue or matter as to which such person shall have been adjudged to be liable to the corporation, absent a determination by a court that such indemnity is proper. </FONT></P>


<P><FONT SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;Section&nbsp;145
further permits a Delaware corporation to grant its directors, officers, employees and agents additional rights of indemnification through bylaw provisions and
otherwise. Section&nbsp;145 further permits a Delaware corporation to purchase and maintain insurance on behalf of any persons who are or were directors, officers, employees or agents of the
corporation, or are or were serving at the request of the corporation as directors, officers, employees or agents of another corporation, partnership, joint venture, trust or other enterprise against
any liability asserted against them and incurred by them in any such capacity, or arising out of their status as such, whether or not the corporation would have the power to indemnify them against
such liability under the other provisions of Section&nbsp;145. </FONT></P>

<P><FONT SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;Section&nbsp;102(b)(7)
of the DGCL provides that a certificate of incorporation may contain a provision eliminating or limiting the personal liability of a director to the
corporation or its stockholders for monetary damages for breach of fiduciary duty as a director, provided that such provision shall not eliminate or limit the liability of a director (i)&nbsp;for
any breach of the director's duty of loyalty to the corporation or its stockholders, (ii)&nbsp;for acts or omissions not in good faith or which involve intentional misconduct or a knowing violation
of law, (iii)&nbsp;under Section&nbsp;174 of the DGCL (relating to liability for unauthorized acquisitions or redemptions of, or dividends on, capital stock) or (iv)&nbsp;for any transaction
from which the director derived an improper personal benefit. The Restated Certificate of Incorporation of the Registrant provides for the indemnification of its directors and officers to the fullest
extent provided by the DGCL. </FONT></P>

<P><FONT SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;The
Restated Certificate of Incorporation further states that the Registrant may, in the sole discretion of its Board of Directors, indemnify any other person to the extent the Board
of Directors deems advisable, as permitted by Section&nbsp;145. The Registrant's By-laws provide that the Registrant shall indemnify its directors, officers, employees and agents,
subject to certain exceptions regarding such persons' standard of conduct. </FONT></P>

<P><FONT SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;In
addition, Article&nbsp;IX, Section&nbsp;(b) of the Registrant's Restated Certificate of Incorporation provides, in part, as follows: </FONT></P>

<UL>

<P><FONT SIZE=2>"No
person shall be personally liable to the corporation or its stockholders for monetary damages for breach of fiduciary duty as a director, </FONT><FONT SIZE=2><I>provided,
however</I></FONT><FONT SIZE=2>, that the foregoing shall not eliminate or limit the liability of a director (i)&nbsp;for any breach of the director's duty of loyalty to the corporation or its
stockholders, (ii)&nbsp;for acts or omissions not in good faith or which involve intentional misconduct or a knowing violation of law, (iii)&nbsp;under Section&nbsp;174 of the Delaware General
Corporation Law, or (iv)&nbsp;for any transaction from which the director derived an improper personal benefit." </FONT></P>

</UL>

<P><FONT SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;In
addition, the Registrant's By-laws provide that it has the power to purchase liability insurance policies covering its directors, officers, employees and agents,
whether or not the Registrant would have the power to indemnify such person under the DGCL. The Registrant currently maintains such insurance. </FONT></P>

<P><FONT SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;The
Registrant has entered into Indemnity Agreements with each of its directors and executive officers. Pursuant to these Agreements, the Registrant has agreed to indemnify each of
its directors and executive officers to the fullest extent permitted by applicable law and the Registrant's By-laws, subject to certain exceptions for (i)&nbsp;claims under
Section&nbsp;16(b) of the Exchange Act, (ii)&nbsp;conduct by the director or executive officer that was knowingly fraudulent or deliberately dishonest or that constituted willful misconduct,
(iii)&nbsp;breaches of the director or executive officer's duty of loyalty, (iv)&nbsp;matters for which the director or executive officer was otherwise indemnified and received payment,
(v)&nbsp;actions for </FONT></P>

<P ALIGN="CENTER"><FONT SIZE=2>2</FONT></P>

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which the director or executive officer may not be legally indemnified and (vi)&nbsp;certain actions initiated by the director or executive officer. </FONT></P>

<P><FONT SIZE=2><B>Item 7. Exemption from Registration Claimed.  </B></FONT></P>


<P><FONT SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;Not applicable. </FONT></P>

<P><FONT SIZE=2><B>Item 8. Exhibits.  </B></FONT></P>

<P><FONT SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;The following exhibits are filed herewith or are incorporated by reference herein as indicated:   </FONT></P>

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4.1</FONT></TD>
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Restated Certificate of Incorporation of the Registrant. (1)</FONT></TD>
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4.2</FONT></TD>
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By-laws of the Registrant, as amended. (2)</FONT></TD>
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5.1</FONT></TD>
<TD WIDTH="3%"><FONT SIZE=2><BR>&nbsp;</FONT></TD>
<TD WIDTH="92%"><FONT SIZE=2><BR>
Opinion of Dechert as to the legality of Common Stock of the Registrant.</FONT></TD>
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23.1</FONT></TD>
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Consent of Ernst &amp; Young LLP, Independent Auditors.</FONT></TD>
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23.2</FONT></TD>
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Consent of Dechert (included in its opinion filed herein as Exhibit 5.1).</FONT></TD>
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24.1</FONT></TD>
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Powers of Attorney (included herein as part of signature page).</FONT></TD>
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<DT><FONT SIZE=2>(1)</FONT></DT><DD><FONT SIZE=2>Filed
as Exhibit&nbsp;3.1 to the Registrant's Annual Report on Form&nbsp;10-K for the year ended December&nbsp;31, 1996 (Commission File
No.&nbsp;0-27188) and incorporated herein by reference.
<BR><BR></FONT></DD><DT><FONT SIZE=2>(2)</FONT></DT><DD><FONT SIZE=2>Filed
as Exhibit&nbsp;3.3 to the Registrant's Annual Report on Form&nbsp;10-K for the year ended December&nbsp;31, 1996 (Commission File
No.&nbsp;0-27188) and incorporated herein by reference. </FONT></DD></DL>

<P><FONT SIZE=2><B>Item 9. Undertakings.  </B></FONT></P>

<UL>

<P><FONT SIZE=2><I> Undertakings required by Item 512(a) of Regulation&nbsp;S-K  </I></FONT></P>

</UL>

<P><FONT SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;The undersigned Registrant hereby undertakes: </FONT></P>

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<DT><FONT SIZE=2>(1)</FONT></DT><DD><FONT SIZE=2>To
file, during any period in which offers or sales are being made, a post-effective amendment to this Registration Statement:
<BR><BR></FONT>
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<DT><FONT SIZE=2>(i)</FONT></DT><DD><FONT SIZE=2>To
include any prospectus required by Section&nbsp;10(a)(3) of the Securities Act;
<BR><BR></FONT></DD><DT><FONT SIZE=2>(ii)</FONT></DT><DD><FONT SIZE=2>To
reflect in the prospectus any facts or events arising after the effective date of the Registration Statement (or the most recent
post-effective amendment thereof) which, individually or in the aggregate, represent a fundamental change in the information set forth in the Registration Statement;
<BR><BR></FONT></DD><DT><FONT SIZE=2>(iii)</FONT></DT><DD><FONT SIZE=2>To
include any material information with respect to the plan of distribution not previously disclosed in the Registration Statement or any
material change to such information in the Registration Statement; </FONT></DD></DL>
</DD></DL>

<P><FONT SIZE=2><I>provided, however,</I></FONT><FONT SIZE=2> that paragraphs (i)&nbsp;and (ii)&nbsp;do not apply if the information required to be included in a post-effective
amendment by those paragraphs is contained in periodic reports filed with or furnished to the Commission by the Registrant pursuant to Section&nbsp;13 or 15(d) of the Exchange Act that are
incorporated by reference in the Registration Statement. </FONT></P>

<DL compact>
<DT><FONT SIZE=2>(2)</FONT></DT><DD><FONT SIZE=2>That,
for the purpose of determining any liability under the Securities Act, each such post-effective amendment shall be deemed to be a new registration statement
relating to the securities offered therein, and the offering of such securities at that time shall be deemed to be the initial </FONT><FONT SIZE=2><I>bona fide </I></FONT><FONT SIZE=2> offering
thereof. </FONT></DD></DL>
<P ALIGN="CENTER"><FONT SIZE=2>3</FONT></P>

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<DT><FONT SIZE=2>(3)</FONT></DT><DD><FONT SIZE=2>To
remove from registration by means of a post-effective amendment any of the securities being registered which remain unsold at the termination of the offering. </FONT></DD></DL>
<UL>

<P><FONT SIZE=2><I> Undertakings required by Item 512(b) of Regulation&nbsp;S-K  </I></FONT></P>

</UL>

<P><FONT SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;The undersigned Registrant hereby undertakes that, for purposes of determining any liability under the Securities Act, each filing of the Registrant's annual
report pursuant to Section&nbsp;13(a) or 15(d) of the Exchange Act (and each filing of an employee benefit plan's annual report pursuant to Section&nbsp;15(d) of the Exchange Act) that is
incorporated by reference in the Registration Statement shall be deemed to be a new registration statement relating to the securities offered therein and the offering of such securities at that time
shall be deemed to be initial </FONT><FONT SIZE=2><I>bona fide</I></FONT><FONT SIZE=2> offering thereof. </FONT></P>

<UL>

<P><FONT SIZE=2><I> Undertakings required by Item 512(h) of Regulation&nbsp;S-K  </I></FONT></P>

</UL>

<P><FONT SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;Insofar as indemnification for liabilities arising under the Securities Act may be permitted to directors, officers and controlling persons of the Registrant
pursuant to the foregoing provisions, or otherwise, the Registrant has been advised that in the opinion of the Commission such indemnification is against public policy as expressed in the Securities
Act and is, therefore, unenforceable. In the event that a claim for indemnification against such liabilities (other than the payment by the Registrant of expenses incurred or paid by a director,
officer or controlling person of the Registrant in the successful defense of any action, suit or proceeding) is asserted by such director, officer or controlling person in connection with the
securities being registered, the Registrant will, unless in the opinion of its counsel the matter has been settled by controlling precedent, submit to a court of appropriate jurisdiction the question
whether such indemnification by it is against public policy as expressed in the Securities Act and will be governed by the final adjudication of such issue. </FONT></P>

<P ALIGN="CENTER"><FONT SIZE=2>4</FONT></P>

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<BR></FONT><FONT SIZE=2><B>SIGNATURES    <BR>  </B></FONT></P>

<P><FONT SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;Pursuant to the requirements of the Securities Act, the Registrant certifies that it has reasonable grounds to believe that it meets all of the requirements
for filing on Form&nbsp;S-8 and has duly caused this Registration Statement to be signed on its behalf by the undersigned, thereunto duly authorized, in the Town of Princeton, State of
New Jersey, on this 9th day of May, 2001. </FONT></P>

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<TD COLSPAN=3><FONT SIZE=2>PHARMACOPEIA,&nbsp;INC.</FONT></TD>
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&nbsp;</FONT></TD>
<TD WIDTH="3%"><FONT SIZE=2><BR>&nbsp;</FONT></TD>
<TD WIDTH="5%"><FONT SIZE=2><BR>
By:</FONT></TD>
<TD WIDTH="1%"><FONT SIZE=2><BR>&nbsp;</FONT></TD>
<TD WIDTH="45%" ALIGN="CENTER"><FONT SIZE=2><BR>
/s/&nbsp;</FONT><FONT SIZE=2>JOSEPH A. MOLLICA</FONT><FONT SIZE=2>&nbsp;&nbsp;&nbsp;</FONT><HR NOSHADE><FONT SIZE=2> Joseph A. Mollica<BR></FONT> <FONT SIZE=2><I>Chairman of the Board of Directors,<BR>
President and Chief Executive Officer<BR> </I></FONT></TD>
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<BR></FONT><FONT SIZE=2><B>POWER OF ATTORNEY    <BR>  </B></FONT></P>

<P><FONT SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;KNOW ALL PERSONS BY THESE PRESENTS, that each person whose signature appears below constitutes and appoints Joseph A. Mollica and Bruce C. Myers, jointly and
severally as his or her attorneys-in-fact, each with full power of substitution, for him or her in any and all capacities, to sign any amendments to this Registration
Statement, and to file the same, with exhibits thereto and other documents in connection therewith, with the Commission, hereby ratifying and confirming all that either of said attorneys-
in-fact, or their substitute or substitutes, may lawfully do or cause to be done by virtue hereof. Pursuant to the requirements of the Securities Act, this Registration Statement has been
signed by the following persons in the capacities and on the dates indicated. </FONT></P>

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<TH WIDTH="35%" ALIGN="CENTER"><FONT SIZE=1><B>SIGNATURE</B></FONT><HR NOSHADE></TH>
<TH WIDTH="3%"><FONT SIZE=1>&nbsp;</FONT></TH>
<TH WIDTH="43%" ALIGN="CENTER"><FONT SIZE=1><B>TITLE</B></FONT><HR NOSHADE></TH>
<TH WIDTH="3%"><FONT SIZE=1>&nbsp;</FONT></TH>
<TH WIDTH="16%" ALIGN="CENTER"><FONT SIZE=1><B>DATE</B></FONT><HR NOSHADE></TH>
</TR>
<TR VALIGN="BOTTOM">
<TD WIDTH="35%" ALIGN="CENTER" VALIGN="CENTER"><BR><FONT SIZE=2>&nbsp;</FONT></TD>
<TD WIDTH="3%" VALIGN="CENTER"><FONT SIZE=2><BR>&nbsp;</FONT></TD>
<TD WIDTH="43%" VALIGN="CENTER"><FONT SIZE=2><BR>
&nbsp;</FONT></TD>
<TD WIDTH="3%" VALIGN="CENTER"><FONT SIZE=2><BR>&nbsp;</FONT></TD>
<TD WIDTH="16%" VALIGN="CENTER"><FONT SIZE=2><BR>
&nbsp;</FONT></TD>
</TR>
<TR VALIGN="TOP">
<TD WIDTH="35%" ALIGN="CENTER" VALIGN="CENTER"><FONT SIZE=2>/s/&nbsp;</FONT><FONT SIZE=2>JOSEPH A. MOLLICA</FONT><FONT SIZE=2>&nbsp;&nbsp;&nbsp;</FONT><HR NOSHADE><FONT SIZE=2> Joseph A. Mollica, Ph.D.</FONT></TD>
<TD WIDTH="3%" VALIGN="CENTER"><FONT SIZE=2>&nbsp;</FONT></TD>
<TD WIDTH="43%" VALIGN="CENTER"><FONT SIZE=2>Chairman of the Board of Directors, President and Chief Executive Officer (Principal Executive Officer)</FONT></TD>
<TD WIDTH="3%" VALIGN="CENTER"><FONT SIZE=2>&nbsp;</FONT></TD>
<TD WIDTH="16%" ALIGN="CENTER" VALIGN="CENTER"><FONT SIZE=2>May 9, 2001</FONT></TD>
</TR>
<TR VALIGN="TOP">
<TD WIDTH="35%" ALIGN="CENTER" VALIGN="CENTER"><FONT SIZE=2><BR>
/s/&nbsp;</FONT><FONT SIZE=2>BRUCE C. MYERS</FONT><FONT SIZE=2>&nbsp;&nbsp;&nbsp;</FONT><HR NOSHADE><FONT SIZE=2> Bruce C. Myers</FONT></TD>
<TD WIDTH="3%" VALIGN="CENTER"><FONT SIZE=2><BR>&nbsp;</FONT></TD>
<TD WIDTH="43%" VALIGN="CENTER"><FONT SIZE=2><BR>
Executive Vice President and Chief Financial Officer and Secretary (Principal Financial and Accounting Officer)</FONT></TD>
<TD WIDTH="3%" VALIGN="CENTER"><FONT SIZE=2><BR>&nbsp;</FONT></TD>
<TD WIDTH="16%" ALIGN="CENTER" VALIGN="CENTER"><FONT SIZE=2><BR>
May 9, 2001</FONT></TD>
</TR>
<TR VALIGN="BOTTOM">
<TD WIDTH="35%" ALIGN="CENTER" VALIGN="CENTER"><FONT SIZE=2><BR>
/s/&nbsp;</FONT><FONT SIZE=2>FRANK BALDINO, JR.</FONT><FONT SIZE=2>&nbsp;&nbsp;&nbsp;</FONT><HR NOSHADE><FONT SIZE=2> Frank Baldino, Jr., Ph.D.</FONT></TD>
<TD WIDTH="3%" VALIGN="CENTER"><FONT SIZE=2><BR>&nbsp;</FONT></TD>
<TD WIDTH="43%" VALIGN="CENTER"><FONT SIZE=2><BR>
Director</FONT></TD>
<TD WIDTH="3%" VALIGN="CENTER"><FONT SIZE=2><BR>&nbsp;</FONT></TD>
<TD WIDTH="16%" ALIGN="CENTER" VALIGN="CENTER"><FONT SIZE=2><BR>
May 9, 2001</FONT></TD>
</TR>
<TR VALIGN="BOTTOM">
<TD WIDTH="35%" ALIGN="CENTER" VALIGN="CENTER"><FONT SIZE=2><BR>
/s/&nbsp;</FONT><FONT SIZE=2>PAUL A. BARTLETT</FONT><FONT SIZE=2>&nbsp;&nbsp;&nbsp;</FONT><HR NOSHADE><FONT SIZE=2> Paul A. Bartlett, Ph.D.</FONT></TD>
<TD WIDTH="3%" VALIGN="CENTER"><FONT SIZE=2><BR>&nbsp;</FONT></TD>
<TD WIDTH="43%" VALIGN="CENTER"><FONT SIZE=2><BR>
Director</FONT></TD>
<TD WIDTH="3%" VALIGN="CENTER"><FONT SIZE=2><BR>&nbsp;</FONT></TD>
<TD WIDTH="16%" ALIGN="CENTER" VALIGN="CENTER"><FONT SIZE=2><BR>
May 9, 2001</FONT></TD>
</TR>
<TR VALIGN="BOTTOM">
<TD WIDTH="35%" ALIGN="CENTER" VALIGN="CENTER"><FONT SIZE=2><BR>
/s/&nbsp;</FONT><FONT SIZE=2>GARY E. COSTLEY</FONT><FONT SIZE=2>&nbsp;&nbsp;&nbsp;</FONT><HR NOSHADE><FONT SIZE=2> Gary E. Costley, Ph.D.</FONT></TD>
<TD WIDTH="3%" VALIGN="CENTER"><FONT SIZE=2><BR>&nbsp;</FONT></TD>
<TD WIDTH="43%" VALIGN="CENTER"><FONT SIZE=2><BR>
Director</FONT></TD>
<TD WIDTH="3%" VALIGN="CENTER"><FONT SIZE=2><BR>&nbsp;</FONT></TD>
<TD WIDTH="16%" ALIGN="CENTER" VALIGN="CENTER"><FONT SIZE=2><BR>
May 9, 2001</FONT></TD>
</TR>
<TR VALIGN="BOTTOM">
<TD WIDTH="35%" ALIGN="CENTER" VALIGN="CENTER"><FONT SIZE=2><BR>
/s/&nbsp;</FONT><FONT SIZE=2>JAMES J. MARINO</FONT><FONT SIZE=2>&nbsp;&nbsp;&nbsp;</FONT><HR NOSHADE><FONT SIZE=2> James J. Marino</FONT></TD>
<TD WIDTH="3%" VALIGN="CENTER"><FONT SIZE=2><BR>&nbsp;</FONT></TD>
<TD WIDTH="43%" VALIGN="CENTER"><FONT SIZE=2><BR>
Director</FONT></TD>
<TD WIDTH="3%" VALIGN="CENTER"><FONT SIZE=2><BR>&nbsp;</FONT></TD>
<TD WIDTH="16%" ALIGN="CENTER" VALIGN="CENTER"><FONT SIZE=2><BR>
May 9, 2001</FONT></TD>
</TR>
<TR VALIGN="BOTTOM">
<TD WIDTH="35%" ALIGN="CENTER" VALIGN="CENTER"><FONT SIZE=2><BR>
/s/&nbsp;</FONT><FONT SIZE=2>CHARLES A. SANDERS</FONT><FONT SIZE=2>&nbsp;&nbsp;&nbsp;</FONT><HR NOSHADE><FONT SIZE=2> Charles A. Sanders, M.D.</FONT></TD>
<TD WIDTH="3%" VALIGN="CENTER"><FONT SIZE=2><BR>&nbsp;</FONT></TD>
<TD WIDTH="43%" VALIGN="CENTER"><FONT SIZE=2><BR>
Director</FONT></TD>
<TD WIDTH="3%" VALIGN="CENTER"><FONT SIZE=2><BR>&nbsp;</FONT></TD>
<TD WIDTH="16%" ALIGN="CENTER" VALIGN="CENTER"><FONT SIZE=2><BR>
May 9, 2001</FONT></TD>
</TR>
<TR VALIGN="BOTTOM">
<TD WIDTH="35%" ALIGN="CENTER" VALIGN="CENTER"><FONT SIZE=2><BR>
/s/&nbsp;</FONT><FONT SIZE=2>RICHARDO B. LEVY</FONT><FONT SIZE=2>&nbsp;&nbsp;&nbsp;</FONT><HR NOSHADE><FONT SIZE=2> Richardo B. Levy, Ph.D.</FONT></TD>
<TD WIDTH="3%" VALIGN="CENTER"><FONT SIZE=2><BR>&nbsp;</FONT></TD>
<TD WIDTH="43%" VALIGN="CENTER"><FONT SIZE=2><BR>
Director</FONT></TD>
<TD WIDTH="3%" VALIGN="CENTER"><FONT SIZE=2><BR>&nbsp;</FONT></TD>
<TD WIDTH="16%" ALIGN="CENTER" VALIGN="CENTER"><FONT SIZE=2><BR>
May 9, 2001</FONT></TD>
</TR>
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<P ALIGN="CENTER"><FONT SIZE=2>5</FONT></P>

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<P ALIGN="CENTER"><FONT SIZE=2><A
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<A NAME="toc_ka1416_1"> </A>
<BR></FONT><FONT SIZE=2><B>EXHIBIT INDEX    <BR>  </B></FONT></P>

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<TH WIDTH="9%" ALIGN="LEFT"><FONT SIZE=1><B>Exhibit No.<BR> </B></FONT><HR NOSHADE></TH>
<TH WIDTH="3%"><FONT SIZE=1>&nbsp;</FONT></TH>
<TH WIDTH="89%" ALIGN="CENTER"><FONT SIZE=1><B>Document</B></FONT><HR NOSHADE></TH>
</TR>
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<TD WIDTH="9%" ALIGN="RIGHT"><FONT SIZE=2>4.1</FONT></TD>
<TD WIDTH="3%"><FONT SIZE=2>&nbsp;</FONT></TD>
<TD WIDTH="89%"><FONT SIZE=2>Restated Certificate of Incorporation of the Registrant. (1)</FONT></TD>
</TR>
<TR VALIGN="TOP">
<TD WIDTH="9%" ALIGN="RIGHT"><FONT SIZE=2><BR>
4.2</FONT></TD>
<TD WIDTH="3%"><FONT SIZE=2><BR>&nbsp;</FONT></TD>
<TD WIDTH="89%"><FONT SIZE=2><BR>
By-laws of the Registrant, as amended. (2)</FONT></TD>
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<TD WIDTH="9%" ALIGN="RIGHT"><FONT SIZE=2><BR>
5.1</FONT></TD>
<TD WIDTH="3%"><FONT SIZE=2><BR>&nbsp;</FONT></TD>
<TD WIDTH="89%"><FONT SIZE=2><BR>
Opinion of Dechert as to the legality of Common Stock of the Registrant.</FONT></TD>
</TR>
<TR VALIGN="TOP">
<TD WIDTH="9%" ALIGN="RIGHT"><FONT SIZE=2><BR>
23.1</FONT></TD>
<TD WIDTH="3%"><FONT SIZE=2><BR>&nbsp;</FONT></TD>
<TD WIDTH="89%"><FONT SIZE=2><BR>
Consent of Ernst &amp; Young LLP, Independent Auditors.</FONT></TD>
</TR>
<TR VALIGN="TOP">
<TD WIDTH="9%" ALIGN="RIGHT"><FONT SIZE=2><BR>
23.2</FONT></TD>
<TD WIDTH="3%"><FONT SIZE=2><BR>&nbsp;</FONT></TD>
<TD WIDTH="89%"><FONT SIZE=2><BR>
Consent of Dechert (included in its opinion filed as Exhibit 5.1).</FONT></TD>
</TR>
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<TD WIDTH="9%" ALIGN="RIGHT"><FONT SIZE=2><BR>
24.1</FONT></TD>
<TD WIDTH="3%"><FONT SIZE=2><BR>&nbsp;</FONT></TD>
<TD WIDTH="89%"><FONT SIZE=2><BR>
Powers of Attorney (included as part of signature page).</FONT></TD>
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<DL compact>
<DT><FONT SIZE=2>(1)</FONT></DT><DD><FONT SIZE=2>Filed
as Exhibit&nbsp;3.1 to the Registrant's Annual Report on Form&nbsp;10-K for the year ended December&nbsp;31, 1996 (Commission File
No.&nbsp;0-27188) and incorporated herein by reference.
<BR><BR></FONT></DD><DT><FONT SIZE=2>(2)</FONT></DT><DD><FONT SIZE=2>Filed
as Exhibit&nbsp;3.3 to the Registrant's Annual Report on Form&nbsp;10-K for the year ended December&nbsp;31, 1996 (Commission File
No.&nbsp;0-27188) and incorporated herein by reference. </FONT></DD></DL>
<P ALIGN="CENTER"><FONT SIZE=2>6</FONT></P>

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<FONT SIZE=2><A HREF="#toc_de1416_1">PART I INFORMATION REQUIRED IN THE SECTION 10(a) PROSPECTUS</A></FONT><BR>
<FONT SIZE=2><A HREF="#toc_de1416_2">PART II INFORMATION REQUIRED IN THE REGISTRATION STATEMENT</A></FONT><BR>
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<FONT SIZE=2><A HREF="#toc_jc1416_1">SIGNATURES</A></FONT><BR>
<FONT SIZE=2><A HREF="#toc_jc1416_2">POWER OF ATTORNEY</A></FONT><BR>
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<FONT SIZE=2><A HREF="#toc_ka1416_1">EXHIBIT INDEX</A></FONT><BR>
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[{"type": "S-8", "sequence": "1", "filename": "a2048326zs-8.htm", "description": "FORM S-8", "secsgml_size_bytes": 34383}]
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Prepared by MERRILL CORPORATION
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As filed with the Securities and Exchange Commission on May 9, 2001
Registration No. 333-_____
SECURITIES AND EXCHANGE COMMISSION
Washington, DC 20549
FORM S-8
REGISTRATION STATEMENT
UNDER
THE SECURITIES ACT OF 1933
PHARMACOPEIA, INC.
(Exact name of Registrant as specified in its charter)
Delaware
(State of Incorporation)
CN 5350
Princeton, New Jersey 08543-5350
(Address of principal executive offices) (Zip Code)
33-0557266
(I.R.S. Employer
Identification No.)
PHARMACOPEIA, INC.
EMPLOYEE STOCK PURCHASE PLAN
(Full Title of the Plan)
Joseph A. Mollica, Ph.D.
Chairman of the Board, President and Chief Executive Officer
Pharmacopeia, Inc.
CN 5350
Princeton, New Jersey 08543-5350
(name and address of agent for service)
(609) 452-3600
(Telephone number, including area code, of agent for service)
COPY TO:
James J. Marino, Esq.
Dechert
Princeton Pike Corporate Center
997 Lenox Drive, Building 3, Suite 210
Lawrenceville, New Jersey 08648
(609) 620-3200
CALCULATION OF REGISTRATION FEE
Title of securities to be registered
Amount to be registered
Proposed maximum offering price per share(1)
Proposed maximum aggregate offering price(1)
Amount of registration fee
Common Stock, par value $0.0001 per share
500,000 shares
$17.93
$8,965,000.00
$2,241.25
(1)
Estimated
solely for the purpose of calculating the registration fee in accordance with paragraph (h) of Rule 457 of the Securities Act of 1933, as amended, on the
basis of the average of the high and low sales price for the Common Stock of Pharmacopeia as reported on the Nasdaq National Market on May 3, 2001.
PART I
INFORMATION REQUIRED IN THE SECTION 10(a) PROSPECTUS
The documents containing information specified in Part I of Form S-8 will be sent or given to employees as specified by
Rule 428(b)(1) of the Securities Act of 1933, as amended (the "Securities Act"). 250,000 shares of Pharmacopeia Common Stock were registered on Form S-8 with respect to the
Pharmacopeia, Inc. Employee Stock Purchase Plan on December 13, 1995.
PART II
INFORMATION REQUIRED IN THE REGISTRATION STATEMENT
Item 3. Incorporation of Documents by Reference.
The following documents of Pharmacopeia, Inc. (the "Registrant") filed or to be filed with the Securities and Exchange Commission (the "Commission") are
incorporated by reference in this Registration Statement as of their respective dates:
(a)
The
Registrant's Annual Report on Form 10-K for the year ended December 31, 2000, which contains audited financial statements for the Registrant's fiscal
year ended December 31, 2000, and all other reports filed by the Registrant with the Commission since December 31, 2000 pursuant to Section 13(a) or 15(d) of the Securities
Exchange Act of 1934, as amended (the "Exchange Act").
(b)
The
description of the Registrant's Common Stock set forth in the Registrant's Registration Statement filed pursuant to Section 12 of the Exchange Act and any amendments or
reports filed for the purpose of updating such description.
(c)
All
reports and documents filed by the Registrant with the Commission pursuant to Sections 13(a), 13(c), 14 and 15(d) of the Exchange Act subsequent to the date of this Registration
Statement and prior to the filing of a post-effective amendment which indicates that all securities offered hereby have been sold or which deregisters all such securities then remaining to
be sold.
Item 4. Description of Securities.
Not applicable.
Item 5. Interests of Named Experts and Counsel.
The validity of the Registrant's Common Stock offered hereby will be passed upon by the law firm of Dechert. James J. Marino, a partner of Dechert, is a
director of the Registrant and owns 1,200 shares of the Registrant's Common Stock.
Item 6. Indemnification of Directors and Officers.
Section 145 ("Section 145") of the Delaware General Corporation Law (the "DGCL") provides generally and in pertinent part that a
Delaware corporation may indemnify its directors, officers, employees and agents against expenses (including attorneys' fees), judgments, fines and settlements actually and reasonably incurred by them
in connection with any civil, criminal, administrative or investigative action, suit or proceeding (except actions by or in the right of the corporation), if, they acted in good faith and in a manner
they reasonably believed to be in, or not opposed to, the best interests of the corporation, and, with respect to any criminal suit or proceeding, they had no reasonable cause to believe their conduct
was unlawful. Section 145 further provides that, in connection with the defense or settlement of any action by or in the right of the corporation, a Delaware corporation may indemnify its
directors, officers, employees and agents against expenses actually and reasonably incurred by them if they acted in good faith and in a manner they reasonably believed to be in, or not opposed to,
the best interests of the corporation, except that no indemnification shall be
1
made in respect of any claim, issue or matter as to which such person shall have been adjudged to be liable to the corporation, absent a determination by a court that such indemnity is proper.
Section 145
further permits a Delaware corporation to grant its directors, officers, employees and agents additional rights of indemnification through bylaw provisions and
otherwise. Section 145 further permits a Delaware corporation to purchase and maintain insurance on behalf of any persons who are or were directors, officers, employees or agents of the
corporation, or are or were serving at the request of the corporation as directors, officers, employees or agents of another corporation, partnership, joint venture, trust or other enterprise against
any liability asserted against them and incurred by them in any such capacity, or arising out of their status as such, whether or not the corporation would have the power to indemnify them against
such liability under the other provisions of Section 145.
Section 102(b)(7)
of the DGCL provides that a certificate of incorporation may contain a provision eliminating or limiting the personal liability of a director to the
corporation or its stockholders for monetary damages for breach of fiduciary duty as a director, provided that such provision shall not eliminate or limit the liability of a director (i) for
any breach of the director's duty of loyalty to the corporation or its stockholders, (ii) for acts or omissions not in good faith or which involve intentional misconduct or a knowing violation
of law, (iii) under Section 174 of the DGCL (relating to liability for unauthorized acquisitions or redemptions of, or dividends on, capital stock) or (iv) for any transaction
from which the director derived an improper personal benefit. The Restated Certificate of Incorporation of the Registrant provides for the indemnification of its directors and officers to the fullest
extent provided by the DGCL.
The
Restated Certificate of Incorporation further states that the Registrant may, in the sole discretion of its Board of Directors, indemnify any other person to the extent the Board
of Directors deems advisable, as permitted by Section 145. The Registrant's By-laws provide that the Registrant shall indemnify its directors, officers, employees and agents,
subject to certain exceptions regarding such persons' standard of conduct.
In
addition, Article IX, Section (b) of the Registrant's Restated Certificate of Incorporation provides, in part, as follows:
"No
person shall be personally liable to the corporation or its stockholders for monetary damages for breach of fiduciary duty as a director,
provided,
however
, that the foregoing shall not eliminate or limit the liability of a director (i) for any breach of the director's duty of loyalty to the corporation or its
stockholders, (ii) for acts or omissions not in good faith or which involve intentional misconduct or a knowing violation of law, (iii) under Section 174 of the Delaware General
Corporation Law, or (iv) for any transaction from which the director derived an improper personal benefit."
In
addition, the Registrant's By-laws provide that it has the power to purchase liability insurance policies covering its directors, officers, employees and agents,
whether or not the Registrant would have the power to indemnify such person under the DGCL. The Registrant currently maintains such insurance.
The
Registrant has entered into Indemnity Agreements with each of its directors and executive officers. Pursuant to these Agreements, the Registrant has agreed to indemnify each of
its directors and executive officers to the fullest extent permitted by applicable law and the Registrant's By-laws, subject to certain exceptions for (i) claims under
Section 16(b) of the Exchange Act, (ii) conduct by the director or executive officer that was knowingly fraudulent or deliberately dishonest or that constituted willful misconduct,
(iii) breaches of the director or executive officer's duty of loyalty, (iv) matters for which the director or executive officer was otherwise indemnified and received payment,
(v) actions for
2
which the director or executive officer may not be legally indemnified and (vi) certain actions initiated by the director or executive officer.
Item 7. Exemption from Registration Claimed.
Not applicable.
Item 8. Exhibits.
The following exhibits are filed herewith or are incorporated by reference herein as indicated:
4.1
Restated Certificate of Incorporation of the Registrant. (1)
4.2
By-laws of the Registrant, as amended. (2)
5.1
Opinion of Dechert as to the legality of Common Stock of the Registrant.
23.1
Consent of Ernst & Young LLP, Independent Auditors.
23.2
Consent of Dechert (included in its opinion filed herein as Exhibit 5.1).
24.1
Powers of Attorney (included herein as part of signature page).
(1)
Filed
as Exhibit 3.1 to the Registrant's Annual Report on Form 10-K for the year ended December 31, 1996 (Commission File
No. 0-27188) and incorporated herein by reference.
(2)
Filed
as Exhibit 3.3 to the Registrant's Annual Report on Form 10-K for the year ended December 31, 1996 (Commission File
No. 0-27188) and incorporated herein by reference.
Item 9. Undertakings.
Undertakings required by Item 512(a) of Regulation S-K
The undersigned Registrant hereby undertakes:
(1)
To
file, during any period in which offers or sales are being made, a post-effective amendment to this Registration Statement:
(i)
To
include any prospectus required by Section 10(a)(3) of the Securities Act;
(ii)
To
reflect in the prospectus any facts or events arising after the effective date of the Registration Statement (or the most recent
post-effective amendment thereof) which, individually or in the aggregate, represent a fundamental change in the information set forth in the Registration Statement;
(iii)
To
include any material information with respect to the plan of distribution not previously disclosed in the Registration Statement or any
material change to such information in the Registration Statement;
provided, however,
that paragraphs (i) and (ii) do not apply if the information required to be included in a post-effective
amendment by those paragraphs is contained in periodic reports filed with or furnished to the Commission by the Registrant pursuant to Section 13 or 15(d) of the Exchange Act that are
incorporated by reference in the Registration Statement.
(2)
That,
for the purpose of determining any liability under the Securities Act, each such post-effective amendment shall be deemed to be a new registration statement
relating to the securities offered therein, and the offering of such securities at that time shall be deemed to be the initial
bona fide
offering
thereof.
3
(3)
To
remove from registration by means of a post-effective amendment any of the securities being registered which remain unsold at the termination of the offering.
Undertakings required by Item 512(b) of Regulation S-K
The undersigned Registrant hereby undertakes that, for purposes of determining any liability under the Securities Act, each filing of the Registrant's annual
report pursuant to Section 13(a) or 15(d) of the Exchange Act (and each filing of an employee benefit plan's annual report pursuant to Section 15(d) of the Exchange Act) that is
incorporated by reference in the Registration Statement shall be deemed to be a new registration statement relating to the securities offered therein and the offering of such securities at that time
shall be deemed to be initial
bona fide
offering thereof.
Undertakings required by Item 512(h) of Regulation S-K
Insofar as indemnification for liabilities arising under the Securities Act may be permitted to directors, officers and controlling persons of the Registrant
pursuant to the foregoing provisions, or otherwise, the Registrant has been advised that in the opinion of the Commission such indemnification is against public policy as expressed in the Securities
Act and is, therefore, unenforceable. In the event that a claim for indemnification against such liabilities (other than the payment by the Registrant of expenses incurred or paid by a director,
officer or controlling person of the Registrant in the successful defense of any action, suit or proceeding) is asserted by such director, officer or controlling person in connection with the
securities being registered, the Registrant will, unless in the opinion of its counsel the matter has been settled by controlling precedent, submit to a court of appropriate jurisdiction the question
whether such indemnification by it is against public policy as expressed in the Securities Act and will be governed by the final adjudication of such issue.
4
SIGNATURES
Pursuant to the requirements of the Securities Act, the Registrant certifies that it has reasonable grounds to believe that it meets all of the requirements
for filing on Form S-8 and has duly caused this Registration Statement to be signed on its behalf by the undersigned, thereunto duly authorized, in the Town of Princeton, State of
New Jersey, on this 9th day of May, 2001.
PHARMACOPEIA, INC.
By:
/s/
JOSEPH A. MOLLICA
Joseph A. Mollica
Chairman of the Board of Directors,
President and Chief Executive Officer
POWER OF ATTORNEY
KNOW ALL PERSONS BY THESE PRESENTS, that each person whose signature appears below constitutes and appoints Joseph A. Mollica and Bruce C. Myers, jointly and
severally as his or her attorneys-in-fact, each with full power of substitution, for him or her in any and all capacities, to sign any amendments to this Registration
Statement, and to file the same, with exhibits thereto and other documents in connection therewith, with the Commission, hereby ratifying and confirming all that either of said attorneys-
in-fact, or their substitute or substitutes, may lawfully do or cause to be done by virtue hereof. Pursuant to the requirements of the Securities Act, this Registration Statement has been
signed by the following persons in the capacities and on the dates indicated.
SIGNATURE
TITLE
DATE
/s/
JOSEPH A. MOLLICA
Joseph A. Mollica, Ph.D.
Chairman of the Board of Directors, President and Chief Executive Officer (Principal Executive Officer)
May 9, 2001
/s/
BRUCE C. MYERS
Bruce C. Myers
Executive Vice President and Chief Financial Officer and Secretary (Principal Financial and Accounting Officer)
May 9, 2001
/s/
FRANK BALDINO, JR.
Frank Baldino, Jr., Ph.D.
Director
May 9, 2001
/s/
PAUL A. BARTLETT
Paul A. Bartlett, Ph.D.
Director
May 9, 2001
/s/
GARY E. COSTLEY
Gary E. Costley, Ph.D.
Director
May 9, 2001
/s/
JAMES J. MARINO
James J. Marino
Director
May 9, 2001
/s/
CHARLES A. SANDERS
Charles A. Sanders, M.D.
Director
May 9, 2001
/s/
RICHARDO B. LEVY
Richardo B. Levy, Ph.D.
Director
May 9, 2001
5
EXHIBIT INDEX
Exhibit No.
Document
4.1
Restated Certificate of Incorporation of the Registrant. (1)
4.2
By-laws of the Registrant, as amended. (2)
5.1
Opinion of Dechert as to the legality of Common Stock of the Registrant.
23.1
Consent of Ernst & Young LLP, Independent Auditors.
23.2
Consent of Dechert (included in its opinion filed as Exhibit 5.1).
24.1
Powers of Attorney (included as part of signature page).
(1)
Filed
as Exhibit 3.1 to the Registrant's Annual Report on Form 10-K for the year ended December 31, 1996 (Commission File
No. 0-27188) and incorporated herein by reference.
(2)
Filed
as Exhibit 3.3 to the Registrant's Annual Report on Form 10-K for the year ended December 31, 1996 (Commission File
No. 0-27188) and incorporated herein by reference.
6
QuickLinks
PART I INFORMATION REQUIRED IN THE SECTION 10(a) PROSPECTUS
PART II INFORMATION REQUIRED IN THE REGISTRATION STATEMENT
SIGNATURES
POWER OF ATTORNEY
EXHIBIT INDEX