<PAGE>
 
   As filed with the Securities and Exchange Commission on November 25, 1997

                                                     REGISTRATION NO. 333 -

================================================================================
 
                      SECURITIES AND EXCHANGE COMMISSION
                            WASHINGTON, D.C. 20549

                                ---------------

                                   FORM S-8
                            REGISTRATION STATEMENT
                                   under the
                            SECURITIES ACT OF 1933

                                ---------------

                             MYRIAD GENETICS, INC.
            (Exact name of Registrant as specified in its charter)

             Delaware                             87-0494517
     (State or other jurisdiction               (I.R.S. Employer
   of incorporation or organization)            Identification No.)

                                320 Wakara Way
                          Salt Lake City, Utah 84108
                                (801) 584-3600
                   (Address of Principal Executive Offices)

                    1992 EMPLOYEE, DIRECTOR AND CONSULTANT
                               STOCK OPTION PLAN
                           (Full title of the plan)

                               PETER D. MELDRUM
                     PRESIDENT AND CHIEF EXECUTIVE OFFICER
                             MYRIAD GENETICS, INC.
                                320 Wakara Way
                          Salt Lake City, Utah 84108
                                (801) 584-3600
                    (Name, address, including zip code, and
                       telephone number, including area
                          code, of agent for service)

                          ---------------------------


                        CALCULATION OF REGISTRATION FEE
<TABLE>
<CAPTION>
========================================================================================================== 
          Title of               Amount to be       Proposed           Proposed          Amount of
 securities to be registered    registered/(1)/     maximum            maximum        registration fee
                                                 offering price       aggregate
                                                 per share/(2)/  offering price/(2)/

----------------------------------------------------------------------------------------------------------
 <S>                            <C>              <C>             <C>                  <C>
 Common Stock, $.01 par value       500,000         $24.9375          $12,468,750        $3,778.41
===========================================================================================================
</TABLE>

(1) The number of shares of common stock, par value $.01 per share ("Common
    Stock"), stated above consists of the aggregate number of additional shares
    not previously registered which may be sold upon the exercise of options
    which have been granted and/or may hereafter be granted under the Myriad
    Genetics, Inc. 1992 Employee, Director and Consultant Stock Option Plan (the
    "Plan").  The maximum number of shares which may be sold upon the exercise
    of such options granted under the Plan is subject to adjustment in
    accordance with certain anti-dilution and other provisions of the Plan.
    Accordingly, pursuant to Rule 416 under the Securities Act of 1933, as
    amended (the "Securities Act"), this Registration Statement covers, in
    addition to the number of shares stated above, an indeterminate number of
    shares which may be subject to grant or otherwise issuable after the
    operation of any such anti-dilution and other provisions.

(2) This calculation is made solely for the purpose of determining the
    registration fee pursuant to the provisions of Rule 457(h) under the
    Securities Act.  The registration fee is calculated on the basis of the
    average of the high and low sale prices per share of the Common Stock on the
    National Market System of the National Association of Securities Dealers
    Automated Quotation System (Nasdaq) as of a date (November 18, 1997) within
    five business days prior to filing this Registration Statement.

================================================================================
<PAGE>
 
                               EXPLANATORY NOTE
                               ----------------


        In accordance with the instructional Note to Part I of Form S-8 as
promulgated by the Securities and Exchange Commission (the "Commission"), the
information specified by Part I of Form S-8 has been omitted from this
Registration Statement on Form S-8 for offers of Common Stock pursuant to the
Plan. This Registration Statement on Form S-8 hereby registers 500,000 new
shares of Common Stock pursuant to the Plan. Registration Statements on Form S-8
(File No. 333-04700 and 333-23255), registering an aggregate of 1,500,000 shares
of Common Stock under the Plan were filed with the Commission on May 3, 1996 and
March 13, 1997, respectively.
<PAGE>
 
                                    PART II

              INFORMATION REQUIRED IN THE REGISTRATION STATEMENT


Item 3. Incorporation of Certain Documents by Reference.
-------------------------------------------------------- 

        The following documents filed by the Company with the Commission are
incorporated herein by reference:

        (a)  The Company's Annual Report on Form 10-K for the fiscal year ended
             June 30, 1997.

        (b)  The Company's Quarterly Report on Form 10-Q for the quarter ended
             September 30, 1997.

        (c)  The description of the Common Stock contained in the Company's
             Registration Statement on Form 8-A (File No. 0-26642) filed under
             the Securities Exchange Act of 1934, including any amendment or
             report filed for the purpose of updating such description.

        All reports and other documents filed by the Company after the date
hereof pursuant to Sections 13(a), 13(c), 14 and 15(d) of the Securities
Exchange Act of 1934 prior to the filing of a post-effective amendment
which indicates that all securities offered hereby have been sold or
which deregisters all securities then remaining unsold, shall be deemed
to be incorporated by reference herein and to be part hereof from the
date of filing of such reports and documents.

Item 4. Description of Securities.
--------------------------------- 

        Not applicable.

Item 5. Interests of Named Experts and Counsel.
---------------------------------------------- 

        The validity of the issuance of the shares of Common Stock registered
under this Registration Statement has been passed upon for the Company by Mintz,
Levin, Cohn, Ferris, Glovsky and Popeo, P.C. of Boston, Massachusetts. Members
of Mintz, Levin, Cohn, Ferris, Glovsky and Popeo, P.C. own an aggregate of
approximately 2,000 shares of Common Stock of the Company.

Item 6. Indemnification of Directors and Officers.
-------------------------------------------------

        Incorporated herein by reference to the Company's Registration Statement
on Form S-1, as amended, File No. 33-95970.

Item 7. Exemption from Registration Claimed.
-------------------------------------------

        Not applicable.

Item 8. Exhibits.
---------------- 

        (4.1)  Form of Common Stock Certificate (filed as Exhibit 4.2 to the
               Company's Registration Statement on Form S-1, as amended, File
               No. 33-95970, and incorporated herein by reference).

        (4.2)  Restated Certificate of Incorporation (filed as Exhibit 3.2 to
               the Company's Registration Statement on Form S-1, as amended,
               File No. 33-95970, and incorporated herein by reference).

                                      II-1
<PAGE>
 
        (4.3)  Restated By-Laws (filed as Exhibit 3.4 to the Company's
               Registration Statement on Form S-1, as amended, File No. 33-
               95970, and incorporated herein by reference).

        (5)    Opinion of Mintz, Levin, Cohn, Ferris, Glovsky and Popeo, P.C.
               as to the legality of the shares being registered.

        (10.1) 1992 Employee, Director and Consultant Stock Option Plan.

        (23.1) Consent of Mintz, Levin, Cohn, Ferris, Glovsky and Popeo, P.C.
               (included in opinion of counsel filed as Exhibit 5).

        (23.2) Consent of KPMG Peat Marwick LLP.

        (24)   Power of Attorney to file future amendments (set forth on the
               signature page of this Registration Statement).

Item 9. Undertakings.
-------------------- 

(a)     The undersigned registrant hereby undertakes:

        (1)  To file, during any period in which offers or sales are being made,
             a post-effective amendment to this Registration Statement:

                 (i)    To include any prospectus required by Section 10(a)(3)
                        of the Securities Act of 1933;

                 (ii)   To reflect in the prospectus any facts or events arising
                        after the effective date of the Registration Statement
                        (or the most recent post-effective amendment thereof)
                        which, individually or in the aggregate, represents a
                        fundamental change in the information set forth in the
                        Registration Statement;

                 (iii)  To include any material information with respect to the
                        plan of distribution not previously disclosed in the
                        Registration Statement or any material change to such
                        information in the Registration Statement;

                     Provided, however, that paragraphs (a)(1)(i) and (a)(1)(ii)
             do not apply if the Registration Statement is on Form S-3 or Form 
             S-8, and the information required to be included in a post-
             effective amendment by those paragraphs is contained in periodic
             reports filed by the Company pursuant to Section 13 or Section
             15(d) of the Securities Exchange Act of 1934 that are incorporated
             by reference in this Registration Statement.

        (2)  That, for the purpose of determining any liability under the
             Securities Act of 1933, each such post-effective amendment shall be
             deemed to be a new registration statement relating to the
             securities offered therein, and the offering of such securities at
             that time shall be deemed to be the initial bona fide offering
             thereof.

        (3)  To remove from registration by means of a post-effective amendment
             any of the securities being registered which remain unsold at the
             termination of the offering.

(b)     The undersigned registrant hereby undertakes that, for purposes of
        determining any liability under the Securities Act of 1933, each filing
        of the Company's annual report pursuant to Section 13(a) or Section
        15(d) 

                                      II-2
<PAGE>
 
        of the Securities Exchange Act of 1934 that is incorporated by reference
        in this Registration Statement shall be deemed to be a new registration
        statement relating to the securities offered therein, and the offering
        of such securities at that time shall be deemed to be the initial bona
        fide offering thereof.

(c)     Insofar as indemnification for liabilities arising under the Securities
        Act of 1933 may be permitted to directors, officers and controlling
        persons of the Company pursuant to the foregoing provisions, or
        otherwise, the Company has been advised that in the opinion of the
        Securities and Exchange Commission such indemnification is against
        public policy as expressed in the Act and is, therefore, unenforceable.
        In the event that a claim for indemnification against such liabilities
        (other than the payment by the Company of expenses incurred or paid by a
        director, officer or controlling person of the Company in the successful
        defense of any action, suit or proceeding) is asserted by such director,
        officer or controlling person in connection with the securities being
        registered, the Company will, unless in the opinion of its counsel the
        matter has been settled by controlling precedent, submit to a court of
        appropriate jurisdiction the question whether such indemnification by it
        is against public policy as expressed in the Act and will be governed by
        the final adjudication of such issue.

                                      II-3
<PAGE>
 
                                  SIGNATURES

        The Registrant. Pursuant to the requirements of the Securities Act of
1933, the Company certifies that it has reasonable grounds to believe that it
meets all of the requirements for filing on Form S-8 and has duly caused this
Registration Statement to be signed on its behalf by the undersigned, thereunto
duly authorized, in Salt Lake City, Utah on November 13, 1997.


                                     MYRIAD GENETICS, INC.



                                     By:/s/ PETER D. MELDRUM
                                        --------------------------------
                                        Peter D. Meldrum
                                        President and Chief Executive Officer

        Each person whose signature appears below constitutes and appoints Peter
D. Meldrum and Jay M. Moyes, and each of them, his true and lawful attorneys-in-
fact and agents, with full power of substitution and resubstitution in each of
them, for him and in his name, place and stead, and in any and all capacities,
to sign any and all amendments (including post-effective amendments) to this
Registration Statement on Form S-8 of Myriad Genetics, Inc., and to file the
same, with all exhibits thereto and other documents in connection therewith,
with the Securities and Exchange Commission, granting unto said attorneys-in-
fact and agents, and each of them, full power and authority to do and perform
each and every act and thing requisite or necessary to be done in or about the
premises, as full to all intents and purposes as he might or could do in person,
hereby ratifying and confirming all that said attorneys-in-fact and agents or
any of them or their or his substitute or substitutes may lawfully do or cause
to be done by virtue hereof.

        Pursuant to the requirements of the Securities Act of 1933, this
Registration Statement has been signed by the following persons in the
capacities and on the dates indicated.

<TABLE> 
<CAPTION> 

   Signature                        Title                         Date
   ---------                        -----                         ----
<S>                           <C>                             <C>   
/s/ JOHN J. HORAN             Chairman of the Board           November 13, 1997
-----------------                                                  
John J. Horan



/s/ WALTER GILBERT, PH.D.     Vice Chairman of the Board      November 13, 1997
-------------------------                                              
Walter Gilbert, Ph.D.



/s/ PETER D. MELDRUM          President, Chief Executive      November 13, 1997
--------------------          Officer and Director 
Peter D. Meldrum              (principal executive officer) 
                          


/s/ MARK H. SKOLNICK, PH.D.   Executive Vice President of     November 13, 1997
---------------------------   Research and Development and            
Mark H. Skolnick, Ph.D.       Director                     

</TABLE> 
                                                            

                                      II-4
<PAGE>
 
<TABLE> 
<S>                               <C>                              <C> 
/s/ JAY M. MOYES                  Vice President of Finance,       November 13, 1997
----------------                  Assistant Secretary and       
Jay M. Moyes                      Treasurer (principal financial
                                  and accounting officer)     
                              

/s/ MICHAEL J. BERENDT, PH.D.     Director                         November 13, 1997
-----------------------------                                       
Michael J. Berendt, Ph.D.


/s/ ARTHUR H. HAYES, JR., M.D.    Director                         November 13, 1997
------------------------------                                       
Arthur H. Hayes, Jr., M.D.



/s/ ALAN J. MAIN, PH.D.           Director                         November 13, 1997
-----------------------                                        
Alan J. Main, Ph.D.



/s/ DALE A. STRINGFELLOW, PH.D.   Director                         November 13, 1997
-------------------------------                                     
Dale A. Stringfellow, Ph.D.
</TABLE> 

                                      II-5
<PAGE>
 
                             MYRIAD GENETICS, INC.

                         INDEX TO EXHIBITS FILED WITH
                        FORM S-8 REGISTRATION STATEMENT
<TABLE>
<CAPTION>
 
 
Exhibit                                                     Sequential
Number                      Description                      Page No.
------                      -----------                      --------
<S>              <C>                                        <C>
 
(4.1)            Form of Common Stock Certificate
                 (filed as Exhibit 4.2 to the Company's
                 Registration Statement on Form S-1, as
                 amended, File No. 33-95970, and
                 incorporated herein by reference).
 
(4.2)            Restated Certificate of Incorporation
                 (filed as Exhibit 3.2 to the Company's
                 Registration Statement on Form S-1, as
                 amended, File No. 33-95970, and
                 incorporated herein by reference).
 
(4.3)            Restated By-Laws (filed as Exhibit 3.4
                 to the Company's Registration
                 Statement on Form S-1, as amended,
                 File No. 33-95970, and incorporated
                 herein by reference).
 
 (5)             Opinion of Mintz, Levin, Cohn, Ferris,
                 Glovsky and Popeo, P.C. as to the
                 legality of the shares being
                 registered.
 
(10.1)           1992 Employee, Director and Consultant
                 Stock Option Plan.
 
(23.1)           Consent of Mintz, Levin, Cohn, Ferris,
                 Glovsky and Popeo, P.C. (included in
                 opinion of counsel filed as Exhibit 5).
 
(23.2)           Consent of KPMG Peat Marwick LLP.
 
 (24)            Power of Attorney to file future
                 amendments (set forth on the signature
                 page of this Registration Statement).
 
</TABLE>

                                      II-6
[{"type": "S-8", "sequence": "1", "description": "FORM S-8", "secsgml_size_bytes": 19201}]
{"company-data": {"conformed-name": "MYRIAD GENETICS INC", "cik": "0000899923", "assigned-sic": "8731", "irs-number": "870494517", "state-of-incorporation": "DE", "fiscal-year-end": "0630"}, "filing-values": {"form-type": "S-8", "act": "33", "file-number": "333-40961", "film-number": "97728065"}, "business-address": {"street1": "320 WAKARA WAY", "city": "SALT LAKE CITY", "state": "UT", "zip": "84108"}, "mail-address": {"street1": "390 WAKARA WAY", "city": "SALT LAKE CITY", "state": "UT", "zip": "84108"}}
As filed with the Securities and Exchange Commission on November 25, 1997

                                                     REGISTRATION NO. 333 -

================================================================================
 
                      SECURITIES AND EXCHANGE COMMISSION
                            WASHINGTON, D.C. 20549

                                ---------------

                                   FORM S-8
                            REGISTRATION STATEMENT
                                   under the
                            SECURITIES ACT OF 1933

                                ---------------

                             MYRIAD GENETICS, INC.
            (Exact name of Registrant as specified in its charter)

             Delaware                             87-0494517
     (State or other jurisdiction               (I.R.S. Employer
   of incorporation or organization)            Identification No.)

                                320 Wakara Way
                          Salt Lake City, Utah 84108
                                (801) 584-3600
                   (Address of Principal Executive Offices)

                    1992 EMPLOYEE, DIRECTOR AND CONSULTANT
                               STOCK OPTION PLAN
                           (Full title of the plan)

                               PETER D. MELDRUM
                     PRESIDENT AND CHIEF EXECUTIVE OFFICER
                             MYRIAD GENETICS, INC.
                                320 Wakara Way
                          Salt Lake City, Utah 84108
                                (801) 584-3600
                    (Name, address, including zip code, and
                       telephone number, including area
                          code, of agent for service)

                          ---------------------------

                        CALCULATION OF REGISTRATION FEE
========================================================================================================== 
          Title of               Amount to be       Proposed           Proposed          Amount of
 securities to be registered    registered/(1)/     maximum            maximum        registration fee
                                                 offering price       aggregate
                                                 per share/(2)/  offering price/(2)/

----------------------------------------------------------------------------------------------------------
Common Stock, $.01 par value       500,000         $24.9375          $12,468,750        $3,778.41
===========================================================================================================
(1) The number of shares of common stock, par value $.01 per share ("Common
    Stock"), stated above consists of the aggregate number of additional shares
    not previously registered which may be sold upon the exercise of options
    which have been granted and/or may hereafter be granted under the Myriad
    Genetics, Inc. 1992 Employee, Director and Consultant Stock Option Plan (the
    "Plan").  The maximum number of shares which may be sold upon the exercise
    of such options granted under the Plan is subject to adjustment in
    accordance with certain anti-dilution and other provisions of the Plan.
    Accordingly, pursuant to Rule 416 under the Securities Act of 1933, as
    amended (the "Securities Act"), this Registration Statement covers, in
    addition to the number of shares stated above, an indeterminate number of
    shares which may be subject to grant or otherwise issuable after the
    operation of any such anti-dilution and other provisions.

(2) This calculation is made solely for the purpose of determining the
    registration fee pursuant to the provisions of Rule 457(h) under the
    Securities Act.  The registration fee is calculated on the basis of the
    average of the high and low sale prices per share of the Common Stock on the
    National Market System of the National Association of Securities Dealers
    Automated Quotation System (Nasdaq) as of a date (November 18, 1997) within
    five business days prior to filing this Registration Statement.

================================================================================
EXPLANATORY NOTE
                               ----------------

        In accordance with the instructional Note to Part I of Form S-8 as
promulgated by the Securities and Exchange Commission (the "Commission"), the
information specified by Part I of Form S-8 has been omitted from this
Registration Statement on Form S-8 for offers of Common Stock pursuant to the
Plan. This Registration Statement on Form S-8 hereby registers 500,000 new
shares of Common Stock pursuant to the Plan. Registration Statements on Form S-8
(File No. 333-04700 and 333-23255), registering an aggregate of 1,500,000 shares
of Common Stock under the Plan were filed with the Commission on May 3, 1996 and
March 13, 1997, respectively.
PART II

              INFORMATION REQUIRED IN THE REGISTRATION STATEMENT

Item 3. Incorporation of Certain Documents by Reference.
-------------------------------------------------------- 

        The following documents filed by the Company with the Commission are
incorporated herein by reference:

        (a)  The Company's Annual Report on Form 10-K for the fiscal year ended
             June 30, 1997.

        (b)  The Company's Quarterly Report on Form 10-Q for the quarter ended
             September 30, 1997.

        (c)  The description of the Common Stock contained in the Company's
             Registration Statement on Form 8-A (File No. 0-26642) filed under
             the Securities Exchange Act of 1934, including any amendment or
             report filed for the purpose of updating such description.

        All reports and other documents filed by the Company after the date
hereof pursuant to Sections 13(a), 13(c), 14 and 15(d) of the Securities
Exchange Act of 1934 prior to the filing of a post-effective amendment
which indicates that all securities offered hereby have been sold or
which deregisters all securities then remaining unsold, shall be deemed
to be incorporated by reference herein and to be part hereof from the
date of filing of such reports and documents.

Item 4. Description of Securities.
--------------------------------- 

        Not applicable.

Item 5. Interests of Named Experts and Counsel.
---------------------------------------------- 

        The validity of the issuance of the shares of Common Stock registered
under this Registration Statement has been passed upon for the Company by Mintz,
Levin, Cohn, Ferris, Glovsky and Popeo, P.C. of Boston, Massachusetts. Members
of Mintz, Levin, Cohn, Ferris, Glovsky and Popeo, P.C. own an aggregate of
approximately 2,000 shares of Common Stock of the Company.

Item 6. Indemnification of Directors and Officers.
-------------------------------------------------

        Incorporated herein by reference to the Company's Registration Statement
on Form S-1, as amended, File No. 33-95970.

Item 7. Exemption from Registration Claimed.
-------------------------------------------

        Not applicable.

Item 8. Exhibits.
---------------- 

        (4.1)  Form of Common Stock Certificate (filed as Exhibit 4.2 to the
               Company's Registration Statement on Form S-1, as amended, File
               No. 33-95970, and incorporated herein by reference).

        (4.2)  Restated Certificate of Incorporation (filed as Exhibit 3.2 to
               the Company's Registration Statement on Form S-1, as amended,
               File No. 33-95970, and incorporated herein by reference).

                                      II-1
(4.3)  Restated By-Laws (filed as Exhibit 3.4 to the Company's
               Registration Statement on Form S-1, as amended, File No. 33-
               95970, and incorporated herein by reference).

        (5)    Opinion of Mintz, Levin, Cohn, Ferris, Glovsky and Popeo, P.C.
               as to the legality of the shares being registered.

        (10.1) 1992 Employee, Director and Consultant Stock Option Plan.

        (23.1) Consent of Mintz, Levin, Cohn, Ferris, Glovsky and Popeo, P.C.
               (included in opinion of counsel filed as Exhibit 5).

        (23.2) Consent of KPMG Peat Marwick LLP.

        (24)   Power of Attorney to file future amendments (set forth on the
               signature page of this Registration Statement).

Item 9. Undertakings.
-------------------- 

(a)     The undersigned registrant hereby undertakes:

        (1)  To file, during any period in which offers or sales are being made,
             a post-effective amendment to this Registration Statement:

                 (i)    To include any prospectus required by Section 10(a)(3)
                        of the Securities Act of 1933;

                 (ii)   To reflect in the prospectus any facts or events arising
                        after the effective date of the Registration Statement
                        (or the most recent post-effective amendment thereof)
                        which, individually or in the aggregate, represents a
                        fundamental change in the information set forth in the
                        Registration Statement;

                 (iii)  To include any material information with respect to the
                        plan of distribution not previously disclosed in the
                        Registration Statement or any material change to such
                        information in the Registration Statement;

                     Provided, however, that paragraphs (a)(1)(i) and (a)(1)(ii)
             do not apply if the Registration Statement is on Form S-3 or Form 
             S-8, and the information required to be included in a post-
             effective amendment by those paragraphs is contained in periodic
             reports filed by the Company pursuant to Section 13 or Section
             15(d) of the Securities Exchange Act of 1934 that are incorporated
             by reference in this Registration Statement.

        (2)  That, for the purpose of determining any liability under the
             Securities Act of 1933, each such post-effective amendment shall be
             deemed to be a new registration statement relating to the
             securities offered therein, and the offering of such securities at
             that time shall be deemed to be the initial bona fide offering
             thereof.

        (3)  To remove from registration by means of a post-effective amendment
             any of the securities being registered which remain unsold at the
             termination of the offering.

(b)     The undersigned registrant hereby undertakes that, for purposes of
        determining any liability under the Securities Act of 1933, each filing
        of the Company's annual report pursuant to Section 13(a) or Section
        15(d) 

                                      II-2
of the Securities Exchange Act of 1934 that is incorporated by reference
        in this Registration Statement shall be deemed to be a new registration
        statement relating to the securities offered therein, and the offering
        of such securities at that time shall be deemed to be the initial bona
        fide offering thereof.

(c)     Insofar as indemnification for liabilities arising under the Securities
        Act of 1933 may be permitted to directors, officers and controlling
        persons of the Company pursuant to the foregoing provisions, or
        otherwise, the Company has been advised that in the opinion of the
        Securities and Exchange Commission such indemnification is against
        public policy as expressed in the Act and is, therefore, unenforceable.
        In the event that a claim for indemnification against such liabilities
        (other than the payment by the Company of expenses incurred or paid by a
        director, officer or controlling person of the Company in the successful
        defense of any action, suit or proceeding) is asserted by such director,
        officer or controlling person in connection with the securities being
        registered, the Company will, unless in the opinion of its counsel the
        matter has been settled by controlling precedent, submit to a court of
        appropriate jurisdiction the question whether such indemnification by it
        is against public policy as expressed in the Act and will be governed by
        the final adjudication of such issue.

                                      II-3
SIGNATURES

        The Registrant. Pursuant to the requirements of the Securities Act of
1933, the Company certifies that it has reasonable grounds to believe that it
meets all of the requirements for filing on Form S-8 and has duly caused this
Registration Statement to be signed on its behalf by the undersigned, thereunto
duly authorized, in Salt Lake City, Utah on November 13, 1997.

                                     MYRIAD GENETICS, INC.

                                     By:/s/ PETER D. MELDRUM
                                        --------------------------------
                                        Peter D. Meldrum
                                        President and Chief Executive Officer

        Each person whose signature appears below constitutes and appoints Peter
D. Meldrum and Jay M. Moyes, and each of them, his true and lawful attorneys-in-
fact and agents, with full power of substitution and resubstitution in each of
them, for him and in his name, place and stead, and in any and all capacities,
to sign any and all amendments (including post-effective amendments) to this
Registration Statement on Form S-8 of Myriad Genetics, Inc., and to file the
same, with all exhibits thereto and other documents in connection therewith,
with the Securities and Exchange Commission, granting unto said attorneys-in-
fact and agents, and each of them, full power and authority to do and perform
each and every act and thing requisite or necessary to be done in or about the
premises, as full to all intents and purposes as he might or could do in person,
hereby ratifying and confirming all that said attorneys-in-fact and agents or
any of them or their or his substitute or substitutes may lawfully do or cause
to be done by virtue hereof.

        Pursuant to the requirements of the Securities Act of 1933, this
Registration Statement has been signed by the following persons in the
capacities and on the dates indicated.
Signature                        Title                         Date
   ---------                        -----                         ----
/s/ JOHN J. HORAN             Chairman of the Board           November 13, 1997
-----------------                                                  
John J. Horan

/s/ WALTER GILBERT, PH.D.     Vice Chairman of the Board      November 13, 1997
-------------------------                                              
Walter Gilbert, Ph.D.

/s/ PETER D. MELDRUM          President, Chief Executive      November 13, 1997
--------------------          Officer and Director 
Peter D. Meldrum              (principal executive officer) 
                          

/s/ MARK H. SKOLNICK, PH.D.   Executive Vice President of     November 13, 1997
---------------------------   Research and Development and            
Mark H. Skolnick, Ph.D.       Director
II-4
/s/ JAY M. MOYES                  Vice President of Finance,       November 13, 1997
----------------                  Assistant Secretary and       
Jay M. Moyes                      Treasurer (principal financial
                                  and accounting officer)     
                              

/s/ MICHAEL J. BERENDT, PH.D.     Director                         November 13, 1997
-----------------------------                                       
Michael J. Berendt, Ph.D.

/s/ ARTHUR H. HAYES, JR., M.D.    Director                         November 13, 1997
------------------------------                                       
Arthur H. Hayes, Jr., M.D.

/s/ ALAN J. MAIN, PH.D.           Director                         November 13, 1997
-----------------------                                        
Alan J. Main, Ph.D.

/s/ DALE A. STRINGFELLOW, PH.D.   Director                         November 13, 1997
-------------------------------                                     
Dale A. Stringfellow, Ph.D.
II-5
MYRIAD GENETICS, INC.

                         INDEX TO EXHIBITS FILED WITH
                        FORM S-8 REGISTRATION STATEMENT
Exhibit                                                     Sequential
Number                      Description                      Page No.
------                      -----------                      --------
(4.1)            Form of Common Stock Certificate
                 (filed as Exhibit 4.2 to the Company's
                 Registration Statement on Form S-1, as
                 amended, File No. 33-95970, and
                 incorporated herein by reference).
 
(4.2)            Restated Certificate of Incorporation
                 (filed as Exhibit 3.2 to the Company's
                 Registration Statement on Form S-1, as
                 amended, File No. 33-95970, and
                 incorporated herein by reference).
 
(4.3)            Restated By-Laws (filed as Exhibit 3.4
                 to the Company's Registration
                 Statement on Form S-1, as amended,
                 File No. 33-95970, and incorporated
                 herein by reference).
 
 (5)             Opinion of Mintz, Levin, Cohn, Ferris,
                 Glovsky and Popeo, P.C. as to the
                 legality of the shares being
                 registered.
 
(10.1)           1992 Employee, Director and Consultant
                 Stock Option Plan.
 
(23.1)           Consent of Mintz, Levin, Cohn, Ferris,
                 Glovsky and Popeo, P.C. (included in
                 opinion of counsel filed as Exhibit 5).
 
(23.2)           Consent of KPMG Peat Marwick LLP.
 
 (24)            Power of Attorney to file future
                 amendments (set forth on the signature
                 page of this Registration Statement).
II-6