<PAGE>

   As filed with the Securities and Exchange Commission on December 22, 1999

                                                       REGISTRATION NO. 333 -


                      SECURITIES AND EXCHANGE COMMISSION
                            WASHINGTON, D.C. 20549

                      -----------------------------------

                                   FORM S-8
                            REGISTRATION STATEMENT
                                   under the
                            SECURITIES ACT OF 1933
                      -----------------------------------

                             MYRIAD GENETICS, INC.
            (Exact name of Registrant as specified in its charter)

             Delaware                                          87-0494517
   (State or other jurisdiction                             (I.R.S. Employer
    of incorporation or organization)                      Identification No.)

                                320 Wakara Way
                          Salt Lake City, Utah 84108
                                (801) 584-3600
                   (Address of Principal Executive Offices)

                    1992 EMPLOYEE, DIRECTOR AND CONSULTANT
                               STOCK OPTION PLAN
                           (Full title of the plan)

                               PETER D. MELDRUM
                     PRESIDENT AND CHIEF EXECUTIVE OFFICER
                             MYRIAD GENETICS, INC.
                                320 Wakara Way
                          Salt Lake City, Utah 84108
                                (801) 584-3600
   (Name, address, including zip code, and telephone number, including area
                          code, of agent for service)
                      -----------------------------------


                        CALCULATION OF REGISTRATION FEE

<TABLE>
<CAPTION>

Title of                               Amount to be        Proposed           Proposed          Amount of
securities to be registered            registered(1)        maximum            maximum       registration fee
                                                        offering price        aggregate
                                                         per share(2)     offering price(2)
<S>                                   <C>              <C>                <C>                <C>
Common Stock, $.01 par value             1,000,000            $32.875        $32,875,000            $8,679.00
</TABLE>



(1) The number of shares of common stock, par value $.01 per share ("Common
    Stock"), stated above consists of the aggregate number of additional shares
    not previously registered which may be sold upon the exercise of options
    which have been granted and/or may hereafter be granted under the Myriad
    Genetics, Inc. 1992 Employee, Director and Consultant Stock Option Plan (the
    "Plan").  The maximum number of shares which may be sold upon the exercise
    of such options granted under the Plan is subject to adjustment in
    accordance with certain anti-dilution and other provisions of the Plan.
    Accordingly, pursuant to Rule 416 under the Securities Act of 1933, as
    amended (the "Securities Act"), this Registration Statement covers, in
    addition to the number of shares stated above, an indeterminate number of
    shares which may be subject to grant or otherwise issuable after the
    operation of any such anti-dilution and other provisions.

(2) This calculation is made solely for the purpose of determining the
    registration fee pursuant to the provisions of Rule 457(h) under the
    Securities Act.  The registration fee is calculated on the basis of the
    average of the high and low sale prices per share of the Common Stock on the
    National Market System of the National Association of Securities Dealers
    Automated Quotation System (Nasdaq) as of a date (December 14, 1999) within
    five business days prior to filing this Registration Statement.


<PAGE>

                                 EXPLANATORY NOTE
                                 ----------------


     In accordance with the instructional Note to Part I of Form S-8 as
promulgated by the Securities and Exchange Commission (the "Commission"), the
information specified by Part I of Form S-8 has been omitted from this
Registration Statement on Form S-8 for offers of Common Stock pursuant to the
Plan.  This Registration Statement on Form S-8 hereby registers 1,000,000 new
shares of Common Stock pursuant to the Plan.  Registration Statements on Form S-
8 (File No. 333-04700, 333-23255 and 333-40961), registering an aggregate of
2,000,000 shares of Common Stock under the Plan were filed with the Commission
on May 3, 1996, March 13, 1997 and November 25, 1997, respectively.
<PAGE>

                                 PART II

              INFORMATION REQUIRED IN THE REGISTRATION STATEMENT


Item 3.  Incorporation of Certain Documents by Reference.
--------------------------------------------------------

     The following documents filed by the Company with the Commission are
     incorporated herein by reference:

     (a)   The Company's Annual Report on Form 10-K for the fiscal year ended
           June 30, 1999.

     (b)   The Company's Quarterly Report on Form 10-Q for the quarter ended
           September 30, 1999.

     (c)   The description of the Common Stock contained in the Company's
           Registration Statement on Form 8-A (File No. 0-26642) filed under the
           Securities Exchange Act of 1934, including any amendment or report
           filed for the purpose of updating such description.

     All reports and other documents filed by the Company after the date hereof
pursuant to Sections 13(a), 13(c), 14 and 15(d) of the Securities Exchange Act
of 1934 prior to the filing of a post-effective amendment which indicates that
all securities offered hereby have been sold or which deregisters all securities
then remaining unsold, shall be deemed to be incorporated by reference herein
and to be part hereof from the date of filing of such reports and documents.

Item 4.  Description of Securities.
----------------------------------

         Not applicable.

Item 5.  Interests of Named Experts and Counsel.
-----------------------------------------------

         The validity of the issuance of the shares of Common Stock registered
under this Registration Statement has been passed upon for the Company by Mintz,
Levin, Cohn, Ferris, Glovsky and Popeo, P.C. of Boston, Massachusetts.

Item 6.  Indemnification of Directors and Officers.
--------------------------------------------------

         Incorporated herein by reference to the Company's Registration
Statement on Form S-1, as amended, File No. 33-95970.

Item 7.  Exemption from Registration Claimed.
--------------------------------------------

         Not applicable.

Item 8.  Exhibits.
-----------------

     (4.1)  Form of Common Stock Certificate (filed as Exhibit 4.2 to the
            Company's Registration Statement on Form S-1, as amended, File No.
            33-95970, and incorporated herein by reference).

     (4.2)  Restated Certificate of Incorporation (filed as Exhibit 3.2 to the
            Company's Registration Statement on Form S-1, as amended, File No.
            33-95970, and incorporated herein by reference).

     (4.3)  Restated By-Laws (filed as Exhibit 3.4 to the Company's Registration
            Statement on Form S-1, as amended, File No. 33-95970, and
            incorporated herein by reference).

                                     II-1
<PAGE>

     (5.1)  Opinion of Mintz, Levin, Cohn, Ferris, Glovsky and Popeo, P.C. as
            to the legality of the shares being registered.

     (10.1) 1992 Employee, Director and Consultant Stock Option Plan.

     (23.1) Consent of Mintz, Levin, Cohn, Ferris, Glovsky and Popeo, P.C.
            (included in opinion of counsel filed as Exhibit 5.1).

     (23.2) Consent of KPMG LLP.

     (24.1) Power of Attorney to file future amendments (set forth on the
            signature page of this Registration Statement).

Item 9.  Undertakings.
---------------------

(a)  The undersigned Registrant hereby undertakes:

     (1) To file, during any period in which offers or sales are being made, a
     post-effective amendment to this Registration Statement:

               (i)   To include any prospectus required by Section 10(a)(3) of
          the Securities Act of 1933;

               (ii)  To reflect in the prospectus any facts or events arising
          after the effective date of the Registration Statement (or the most
          recent post-effective amendment thereof) which, individually or in the
          aggregate, represents a fundamental change in the information set
          forth in the Registration Statement.  Notwithstanding the foregoing,
          any increase or decrease in volume of securities offered (if the total
          dollar value of securities offered would not exceed that which was
          registered) and any deviation from the low or high end of the
          estimated maximum offering range may be reflected in the form of
          prospectus filed with the Commission pursuant to Rule 424(b) if, in
          the aggregate, the changes in volume and price represent no more than
          a 20% change in the maximum aggregate offering price set forth in the
          "Calculation of Registration Fee" table in the effective Registration
          Statement.

               (iii) To include any material information with respect to the
          plan of distribution not previously disclosed in the Registration
          Statement or any material change to such information in the
          Registration Statement;

          Provided, however, that paragraphs (a)(1)(i) and (a)(1)(ii) do not
     apply if the Registration Statement is on Form S-3 or Form S-8, and the
     information required to be included in a post-effective amendment by those
     paragraphs is contained in periodic reports filed by the Registrant
     pursuant to Section 13 or Section 15(d) of the Securities Exchange Act of
     1934 that are incorporated by reference in the Registration Statement.

     (2)  That, for the purpose of determining any liability under the
     Securities Act of 1933, each such post-effective amendment shall be deemed
     to be a new registration statement relating to the securities offered
     therein, and the offering of such securities at that time shall be deemed
     to be the initial bona fide offering thereof.

     (3)  To remove from registration by means of a post-effective amendment any
     of the securities being registered which remain unsold at the termination
     of the offering.

                                     II-2
<PAGE>

(b)  The undersigned Registrant hereby undertakes that, for purposes of
     determining any liability under the Securities Act of 1933, each filing of
     the Registrant's annual report pursuant to Section 13(a) or Section 15(d)
     of the Securities Exchange Act of 1934 that is incorporated by reference in
     this Registration Statement shall be deemed to be a new registration
     statement relating to the securities offered therein, and the offering of
     such securities at that time shall be deemed to be the initial bona fide
     offering thereof.

(c)  Insofar as indemnification for liabilities arising under the Securities Act
     of 1933 may be permitted to directors, officers and controlling persons of
     the Registrant, the Registrant has been advised that in the opinion of the
     Securities and Exchange Commission such indemnification is against public
     policy as expressed in the Act and is, therefore, unenforceable.  In the
     event that a claim for indemnification against such liabilities (other than
     the payment by the Registrant of expenses incurred or paid by a director,
     officer or controlling person of the Registrant in the successful defense
     of any action, suit or proceeding) is asserted by such director, officer or
     controlling person in connection with the securities being registered, the
     Registrant will, unless in the opinion of its counsel the matter has been
     settled by controlling precedent, submit to a court of appropriate
     jurisdiction the question whether such indemnification by it is against
     public policy as expressed in the Act and will be governed by the final
     adjudication of such issue.

                                     II-3
<PAGE>

     SIGNATURES

     The Registrant.  Pursuant to the requirements of the Securities Act of
1933, the Company certifies that it has reasonable grounds to believe that it
meets all of the requirements for filing on Form S-8 and has duly caused this
Registration Statement to be signed on its behalf by the undersigned, thereunto
duly authorized, in Salt Lake City, Utah on December 22, 1999.


                                    MYRIAD GENETICS, INC.



                                    By:/s/ PETER D. MELDRUM
                                       --------------------------------
                                       Peter D. Meldrum
                                       President and Chief Executive Officer

     Each person whose signature appears below constitutes and appoints Peter D.
Meldrum and Jay M. Moyes, and each of them, his true and lawful attorneys-in-
fact and agents, with full power of substitution and resubstitution in each of
them, for him and in his name, place and stead, and in any and all capacities,
to sign any and all amendments (including post-effective amendments) to this
Registration Statement on Form S-8 of Myriad Genetics, Inc., and to file the
same, with all exhibits thereto and other documents in connection therewith,
with the Securities and Exchange Commission, granting unto said attorneys-in-
fact and agents, and each of them, full power and authority to do and perform
each and every act and thing requisite or necessary to be done in or about the
premises, as full to all intents and purposes as he might or could do in person,
hereby ratifying and confirming all that said attorneys-in-fact and agents or
any of them or their or his substitute or substitutes may lawfully do or cause
to be done by virtue hereof.

     Pursuant to the requirements of the Securities Act of 1933, this
Registration Statement has been signed by the following persons in the
capacities and on the dates indicated.

     Signature                   Title                      Date
     ---------                   -----                      ----


/s/ JOHN J. HORAN           Chairman of the Board         December 22, 1999
-----------------
John J. Horan



/s/ WALTER GILBERT, PH.D    Vice Chairman of the Board    December 22, 1999
------------------------
Walter Gilbert, Ph.D.



/s/ PETER D. MELDRUM        President, Chief Executive    December 22, 1999
--------------------        Officer and Director
Peter D. Meldrum                   (principal executive officer)




/s/ MARK H. SKOLNICK, PH.D. Executive Vice President of    December 22, 1999
--------------------------- Research and Development and
Mark H. Skolnick, Ph.D.     Director


                                     II-4
<PAGE>

/s/ JAY M. MOYES            Vice President of Finance,      December 22, 1999
----------------            Assistant Secretary and
Jay M. Moyes                Treasurer (principal financial
                            and accounting officer)





/s/ MICHAEL J. BERENDT, PH.D.   Director                    December 22, 1999
-----------------------------
Michael J. Berendt, Ph.D.



/s/ ARTHUR H. HAYES, JR., M.D.  Director                    December 22, 1999
------------------------------
Arthur H. Hayes, Jr., M.D.



/s/ ALAN J. MAIN, PH.D.         Director                    December 22, 1999
-----------------------
Alan J. Main, Ph.D.



/s/ DALE A. STRINGFELLOW, PH.D. Director                    December 22, 1999
-------------------------------
Dale A. Stringfellow, Ph.D.



/s/ LINDA S. WILSON, PH.D.      Director                    December 22, 1999
--------------------------
Linda S. Wilson, Ph.D.

                                     II-5
<PAGE>

                             MYRIAD GENETICS, INC.

                         INDEX TO EXHIBITS FILED WITH
                        FORM S-8 REGISTRATION STATEMENT

Exhibit                                                         Sequential
Number                         Description                        Page No.
-------                        -----------                      -----------

(4.1)     Form of Common Stock Certificate (filed as Exhibit 4.2 to the
          Company's Registration Statement on Form S-1, as amended, File No.
          33-95970, and incorporated herein by reference).

(4.2)     Restated Certificate of Incorporation (filed as Exhibit 3.2 to the
          Company's Registration Statement on Form S-1, as amended, File No.
          33-95970, and incorporated herein by reference).

(4.3)     Restated By-Laws (filed as Exhibit 3.4 to the Company's Registration
          Statement on Form S-1, as amended, File No. 33-95970, and
          incorporated herein by reference).

(5.1)     Opinion of Mintz, Levin, Cohn, Ferris, Glovsky and Popeo, P.C. as to
          the legality of the shares being registered.

(10.1)    1992 Employee, Director and Consultant Stock Option Plan.

(23.1)    Consent of Mintz, Levin, Cohn, Ferris, Glovsky and Popeo, P.C.
          (included in opinion of counsel filed as Exhibit 5.1).

(23.2)    Consent of KPMG LLP.

(24.1)    Power of Attorney to file future amendments (set forth on the
          signature page of this Registration Statement).



TRADOCS:1267425.3(r5y903!.DOC)

                                     II-6
[{"type": "S-8", "sequence": "1", "description": "REGISTRATION STATEMENT", "secsgml_size_bytes": 17897}]
{"company-data": {"conformed-name": "MYRIAD GENETICS INC", "cik": "0000899923", "assigned-sic": "8731", "irs-number": "870494517", "state-of-incorporation": "DE", "fiscal-year-end": "0630"}, "filing-values": {"form-type": "S-8", "act": "33", "file-number": "333-93363", "film-number": "99778913"}, "business-address": {"street1": "320 WAKARA WAY", "city": "SALT LAKE CITY", "state": "UT", "zip": "84108"}, "mail-address": {"street1": "390 WAKARA WAY", "city": "SALT LAKE CITY", "state": "UT", "zip": "84108"}}
As filed with the Securities and Exchange Commission on December 22, 1999

                                                       REGISTRATION NO. 333 -

                      SECURITIES AND EXCHANGE COMMISSION
                            WASHINGTON, D.C. 20549

                      -----------------------------------

                                   FORM S-8
                            REGISTRATION STATEMENT
                                   under the
                            SECURITIES ACT OF 1933
                      -----------------------------------

                             MYRIAD GENETICS, INC.
            (Exact name of Registrant as specified in its charter)

             Delaware                                          87-0494517
   (State or other jurisdiction                             (I.R.S. Employer
    of incorporation or organization)                      Identification No.)

                                320 Wakara Way
                          Salt Lake City, Utah 84108
                                (801) 584-3600
                   (Address of Principal Executive Offices)

                    1992 EMPLOYEE, DIRECTOR AND CONSULTANT
                               STOCK OPTION PLAN
                           (Full title of the plan)

                               PETER D. MELDRUM
                     PRESIDENT AND CHIEF EXECUTIVE OFFICER
                             MYRIAD GENETICS, INC.
                                320 Wakara Way
                          Salt Lake City, Utah 84108
                                (801) 584-3600
   (Name, address, including zip code, and telephone number, including area
                          code, of agent for service)
                      -----------------------------------

                        CALCULATION OF REGISTRATION FEE
Title of                               Amount to be        Proposed           Proposed          Amount of
securities to be registered            registered(1)        maximum            maximum       registration fee
                                                        offering price        aggregate
                                                         per share(2)     offering price(2)
Common Stock, $.01 par value             1,000,000            $32.875        $32,875,000            $8,679.00
(1) The number of shares of common stock, par value $.01 per share ("Common
    Stock"), stated above consists of the aggregate number of additional shares
    not previously registered which may be sold upon the exercise of options
    which have been granted and/or may hereafter be granted under the Myriad
    Genetics, Inc. 1992 Employee, Director and Consultant Stock Option Plan (the
    "Plan").  The maximum number of shares which may be sold upon the exercise
    of such options granted under the Plan is subject to adjustment in
    accordance with certain anti-dilution and other provisions of the Plan.
    Accordingly, pursuant to Rule 416 under the Securities Act of 1933, as
    amended (the "Securities Act"), this Registration Statement covers, in
    addition to the number of shares stated above, an indeterminate number of
    shares which may be subject to grant or otherwise issuable after the
    operation of any such anti-dilution and other provisions.

(2) This calculation is made solely for the purpose of determining the
    registration fee pursuant to the provisions of Rule 457(h) under the
    Securities Act.  The registration fee is calculated on the basis of the
    average of the high and low sale prices per share of the Common Stock on the
    National Market System of the National Association of Securities Dealers
    Automated Quotation System (Nasdaq) as of a date (December 14, 1999) within
    five business days prior to filing this Registration Statement.
EXPLANATORY NOTE
                                 ----------------

     In accordance with the instructional Note to Part I of Form S-8 as
promulgated by the Securities and Exchange Commission (the "Commission"), the
information specified by Part I of Form S-8 has been omitted from this
Registration Statement on Form S-8 for offers of Common Stock pursuant to the
Plan.  This Registration Statement on Form S-8 hereby registers 1,000,000 new
shares of Common Stock pursuant to the Plan.  Registration Statements on Form S-
8 (File No. 333-04700, 333-23255 and 333-40961), registering an aggregate of
2,000,000 shares of Common Stock under the Plan were filed with the Commission
on May 3, 1996, March 13, 1997 and November 25, 1997, respectively.
PART II

              INFORMATION REQUIRED IN THE REGISTRATION STATEMENT

Item 3.  Incorporation of Certain Documents by Reference.
--------------------------------------------------------

     The following documents filed by the Company with the Commission are
     incorporated herein by reference:

     (a)   The Company's Annual Report on Form 10-K for the fiscal year ended
           June 30, 1999.

     (b)   The Company's Quarterly Report on Form 10-Q for the quarter ended
           September 30, 1999.

     (c)   The description of the Common Stock contained in the Company's
           Registration Statement on Form 8-A (File No. 0-26642) filed under the
           Securities Exchange Act of 1934, including any amendment or report
           filed for the purpose of updating such description.

     All reports and other documents filed by the Company after the date hereof
pursuant to Sections 13(a), 13(c), 14 and 15(d) of the Securities Exchange Act
of 1934 prior to the filing of a post-effective amendment which indicates that
all securities offered hereby have been sold or which deregisters all securities
then remaining unsold, shall be deemed to be incorporated by reference herein
and to be part hereof from the date of filing of such reports and documents.

Item 4.  Description of Securities.
----------------------------------

         Not applicable.

Item 5.  Interests of Named Experts and Counsel.
-----------------------------------------------

         The validity of the issuance of the shares of Common Stock registered
under this Registration Statement has been passed upon for the Company by Mintz,
Levin, Cohn, Ferris, Glovsky and Popeo, P.C. of Boston, Massachusetts.

Item 6.  Indemnification of Directors and Officers.
--------------------------------------------------

         Incorporated herein by reference to the Company's Registration
Statement on Form S-1, as amended, File No. 33-95970.

Item 7.  Exemption from Registration Claimed.
--------------------------------------------

         Not applicable.

Item 8.  Exhibits.
-----------------

     (4.1)  Form of Common Stock Certificate (filed as Exhibit 4.2 to the
            Company's Registration Statement on Form S-1, as amended, File No.
            33-95970, and incorporated herein by reference).

     (4.2)  Restated Certificate of Incorporation (filed as Exhibit 3.2 to the
            Company's Registration Statement on Form S-1, as amended, File No.
            33-95970, and incorporated herein by reference).

     (4.3)  Restated By-Laws (filed as Exhibit 3.4 to the Company's Registration
            Statement on Form S-1, as amended, File No. 33-95970, and
            incorporated herein by reference).

                                     II-1
(5.1)  Opinion of Mintz, Levin, Cohn, Ferris, Glovsky and Popeo, P.C. as
            to the legality of the shares being registered.

     (10.1) 1992 Employee, Director and Consultant Stock Option Plan.

     (23.1) Consent of Mintz, Levin, Cohn, Ferris, Glovsky and Popeo, P.C.
            (included in opinion of counsel filed as Exhibit 5.1).

     (23.2) Consent of KPMG LLP.

     (24.1) Power of Attorney to file future amendments (set forth on the
            signature page of this Registration Statement).

Item 9.  Undertakings.
---------------------

(a)  The undersigned Registrant hereby undertakes:

     (1) To file, during any period in which offers or sales are being made, a
     post-effective amendment to this Registration Statement:

               (i)   To include any prospectus required by Section 10(a)(3) of
          the Securities Act of 1933;

               (ii)  To reflect in the prospectus any facts or events arising
          after the effective date of the Registration Statement (or the most
          recent post-effective amendment thereof) which, individually or in the
          aggregate, represents a fundamental change in the information set
          forth in the Registration Statement.  Notwithstanding the foregoing,
          any increase or decrease in volume of securities offered (if the total
          dollar value of securities offered would not exceed that which was
          registered) and any deviation from the low or high end of the
          estimated maximum offering range may be reflected in the form of
          prospectus filed with the Commission pursuant to Rule 424(b) if, in
          the aggregate, the changes in volume and price represent no more than
          a 20% change in the maximum aggregate offering price set forth in the
          "Calculation of Registration Fee" table in the effective Registration
          Statement.

               (iii) To include any material information with respect to the
          plan of distribution not previously disclosed in the Registration
          Statement or any material change to such information in the
          Registration Statement;

          Provided, however, that paragraphs (a)(1)(i) and (a)(1)(ii) do not
     apply if the Registration Statement is on Form S-3 or Form S-8, and the
     information required to be included in a post-effective amendment by those
     paragraphs is contained in periodic reports filed by the Registrant
     pursuant to Section 13 or Section 15(d) of the Securities Exchange Act of
     1934 that are incorporated by reference in the Registration Statement.

     (2)  That, for the purpose of determining any liability under the
     Securities Act of 1933, each such post-effective amendment shall be deemed
     to be a new registration statement relating to the securities offered
     therein, and the offering of such securities at that time shall be deemed
     to be the initial bona fide offering thereof.

     (3)  To remove from registration by means of a post-effective amendment any
     of the securities being registered which remain unsold at the termination
     of the offering.

                                     II-2
(b)  The undersigned Registrant hereby undertakes that, for purposes of
     determining any liability under the Securities Act of 1933, each filing of
     the Registrant's annual report pursuant to Section 13(a) or Section 15(d)
     of the Securities Exchange Act of 1934 that is incorporated by reference in
     this Registration Statement shall be deemed to be a new registration
     statement relating to the securities offered therein, and the offering of
     such securities at that time shall be deemed to be the initial bona fide
     offering thereof.

(c)  Insofar as indemnification for liabilities arising under the Securities Act
     of 1933 may be permitted to directors, officers and controlling persons of
     the Registrant, the Registrant has been advised that in the opinion of the
     Securities and Exchange Commission such indemnification is against public
     policy as expressed in the Act and is, therefore, unenforceable.  In the
     event that a claim for indemnification against such liabilities (other than
     the payment by the Registrant of expenses incurred or paid by a director,
     officer or controlling person of the Registrant in the successful defense
     of any action, suit or proceeding) is asserted by such director, officer or
     controlling person in connection with the securities being registered, the
     Registrant will, unless in the opinion of its counsel the matter has been
     settled by controlling precedent, submit to a court of appropriate
     jurisdiction the question whether such indemnification by it is against
     public policy as expressed in the Act and will be governed by the final
     adjudication of such issue.

                                     II-3
SIGNATURES

     The Registrant.  Pursuant to the requirements of the Securities Act of
1933, the Company certifies that it has reasonable grounds to believe that it
meets all of the requirements for filing on Form S-8 and has duly caused this
Registration Statement to be signed on its behalf by the undersigned, thereunto
duly authorized, in Salt Lake City, Utah on December 22, 1999.

                                    MYRIAD GENETICS, INC.

                                    By:/s/ PETER D. MELDRUM
                                       --------------------------------
                                       Peter D. Meldrum
                                       President and Chief Executive Officer

     Each person whose signature appears below constitutes and appoints Peter D.
Meldrum and Jay M. Moyes, and each of them, his true and lawful attorneys-in-
fact and agents, with full power of substitution and resubstitution in each of
them, for him and in his name, place and stead, and in any and all capacities,
to sign any and all amendments (including post-effective amendments) to this
Registration Statement on Form S-8 of Myriad Genetics, Inc., and to file the
same, with all exhibits thereto and other documents in connection therewith,
with the Securities and Exchange Commission, granting unto said attorneys-in-
fact and agents, and each of them, full power and authority to do and perform
each and every act and thing requisite or necessary to be done in or about the
premises, as full to all intents and purposes as he might or could do in person,
hereby ratifying and confirming all that said attorneys-in-fact and agents or
any of them or their or his substitute or substitutes may lawfully do or cause
to be done by virtue hereof.

     Pursuant to the requirements of the Securities Act of 1933, this
Registration Statement has been signed by the following persons in the
capacities and on the dates indicated.

     Signature                   Title                      Date
     ---------                   -----                      ----

/s/ JOHN J. HORAN           Chairman of the Board         December 22, 1999
-----------------
John J. Horan

/s/ WALTER GILBERT, PH.D    Vice Chairman of the Board    December 22, 1999
------------------------
Walter Gilbert, Ph.D.

/s/ PETER D. MELDRUM        President, Chief Executive    December 22, 1999
--------------------        Officer and Director
Peter D. Meldrum                   (principal executive officer)

/s/ MARK H. SKOLNICK, PH.D. Executive Vice President of    December 22, 1999
--------------------------- Research and Development and
Mark H. Skolnick, Ph.D.     Director

                                     II-4
/s/ JAY M. MOYES            Vice President of Finance,      December 22, 1999
----------------            Assistant Secretary and
Jay M. Moyes                Treasurer (principal financial
                            and accounting officer)

/s/ MICHAEL J. BERENDT, PH.D.   Director                    December 22, 1999
-----------------------------
Michael J. Berendt, Ph.D.

/s/ ARTHUR H. HAYES, JR., M.D.  Director                    December 22, 1999
------------------------------
Arthur H. Hayes, Jr., M.D.

/s/ ALAN J. MAIN, PH.D.         Director                    December 22, 1999
-----------------------
Alan J. Main, Ph.D.

/s/ DALE A. STRINGFELLOW, PH.D. Director                    December 22, 1999
-------------------------------
Dale A. Stringfellow, Ph.D.

/s/ LINDA S. WILSON, PH.D.      Director                    December 22, 1999
--------------------------
Linda S. Wilson, Ph.D.

                                     II-5
MYRIAD GENETICS, INC.

                         INDEX TO EXHIBITS FILED WITH
                        FORM S-8 REGISTRATION STATEMENT

Exhibit                                                         Sequential
Number                         Description                        Page No.
-------                        -----------                      -----------

(4.1)     Form of Common Stock Certificate (filed as Exhibit 4.2 to the
          Company's Registration Statement on Form S-1, as amended, File No.
          33-95970, and incorporated herein by reference).

(4.2)     Restated Certificate of Incorporation (filed as Exhibit 3.2 to the
          Company's Registration Statement on Form S-1, as amended, File No.
          33-95970, and incorporated herein by reference).

(4.3)     Restated By-Laws (filed as Exhibit 3.4 to the Company's Registration
          Statement on Form S-1, as amended, File No. 33-95970, and
          incorporated herein by reference).

(5.1)     Opinion of Mintz, Levin, Cohn, Ferris, Glovsky and Popeo, P.C. as to
          the legality of the shares being registered.

(10.1)    1992 Employee, Director and Consultant Stock Option Plan.

(23.1)    Consent of Mintz, Levin, Cohn, Ferris, Glovsky and Popeo, P.C.
          (included in opinion of counsel filed as Exhibit 5.1).

(23.2)    Consent of KPMG LLP.

(24.1)    Power of Attorney to file future amendments (set forth on the
          signature page of this Registration Statement).

TRADOCS:1267425.3(r5y903!.DOC)

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