<PAGE>

         As filed with the Securities and Exchange Commission on July 25, 1997
                                                    Registration No. 333-10043
------------------------------------------------------------------------------
------------------------------------------------------------------------------

                      SECURITIES AND EXCHANGE COMMISSION
                            Washington, D.C. 20549
                                       


                                   FORM S-8
                            REGISTRATION STATEMENT
                                     UNDER
                          THE SECURITIES ACT OF 1933 
                                       

                       FUSION MEDICAL TECHNOLOGIES, INC.
            (Exact name of registrant as specified in its charter)

<TABLE>
<S>                                                                        <C>
                          Delaware                                                     94-3177221
           -------------------------------------                              ----------------------------
(State or other jurisdiction of incorporation or organization)             (I.R.S. Employer Identification No.)
</TABLE>

                             1615 Plymouth Street
                        Mountain View, California 94043
                   (Address of principal executive offices)
                                       

                            1993 STOCK OPTION PLAN

                           (Full title of the Plans)
                                       

                               PHILIP M. SAWYER
                     President and Chief Executive Officer
                       Fusion Medical Technologies, Inc.
                             1615 Plymouth Street
                        Mountain View, California 94043
                                (415) 903-4000
           (Name, address and telephone number of agent for service)
                                       

                                   COPY TO:
                            John T. Sheridan, Esq.
                       Wilson Sonsini Goodrich & Rosati
                           Professional Corporation
                              650 Page Mill Road
                       Palo Alto, California 94304-1050
                                (415) 493-9300

------------------------------------------------------------------------------
------------------------------------------------------------------------------
<PAGE>

<TABLE>
<CAPTION>
--------------------------------------------------------------------------------------------------------------------
--------------------------------------------------------------------------------------------------------------------
                                          CALCULATION OF REGISTRATION FEE
--------------------------------------------------------------------------------------------------------------------
--------------------------------------------------------------------------------------------------------------------
                                                                Proposed            Proposed
        Title of                                                 Maximum             Maximum
       Securities                          Amount                Offering           Aggregate            Amount of
          to be                            to be                  Price             Offering            Registration
       Registered                        Registered             Per Share             Price                 Fee
<S>                                       <C>                     <C>              <C>                     <C>
1993 Stock Option Plan
Common Stock, $.001 par value(1)          300,000                 $4.375           $1,312,500(2)           $397.73
--------------------------------------------------------------------------------------------------------------------
--------------------------------------------------------------------------------------------------------------------
</TABLE>

(1) In addition, pursuant to Rule 416(c) under the Securities Act of 1933, as
    amended, this Registration Statement also covers an indeterminate amount of
    interests to be offered or sold pursuant to the employee benefit plan
    described herein.

(2) Registration fee estimated in accordance with Rule 457(c) under the
    Securities Act of 1933, as amended, as to 300,000 shares of Common Stock,
    solely for the purpose of calculating the registration fee.  The
    computation is based upon the closing price of the Common Stock as reported
    on the Nasdaq National Market on July 22, 1997 because the price at which
    the options to be granted in the future may be exercised is not currently
    determinable.


                                       2
<PAGE>

 STATEMENT UNDER GENERAL INSTRUCTION E - REGISTRATION OF ADDITIONAL SECURITIES

    The Registrant previously filed one Registration Statement on Form S-8 
with the Securities and Exchange  Commission (SEC File No. 333-10043) (the 
"Previous Form S-8).  This Previous Form S-8 was filed in connection with the 
1993 Stock Option Plan, the 1996 Director Option Plan and the 1996 Employee 
Stock Purchase Plan (collectively the "Plans").  This Registration Statement 
registers additional shares of the Registrant's Common Stock to be issued 
pursuant to the Plans.  Accordingly, the content of the Previous Form S-8, 
including periodic reports that the Registrant filed after the Previous Form 
S-8 to maintain current information about the Registrant, are incorporated by 
reference into this Registration Statement pursuant to General Instruction E 
of Form S-8.  The reports the Registrant has most recently filed with the SEC 
are listed below:

    -    Annual Report on Form 10-K for the fiscal year ended December 31,
         1996, filed as of March 31, 1997.

    -    Quarterly Report on Form 10-Q for the quarterly period ended March 31,
         1997, filed as of May 15, 1997.

    -    Proxy Statement, filed as of April 28, 1997, in connection with the
         Annual Meeting of Shareholders held on May 22, 1997.

                                    PART II

              INFORMATION REQUIRED IN THE REGISTRATION STATEMENT

Item 8.  EXHIBITS.
         --------

         Exhibit 
         Number                          Document
         --------   ------------------------------------------------------

          5.1       Opinion of Wilson Sonsini Goodrich & Rosati, P.C., as 
                    to the legality of securities being registered.

         23.1       Consent of Coopers & Lybrand L.L.P., Independent Auditors.

         23.2       Consent of Wilson Sonsini Goodrich & Rosati, P.C. 
                    (contained in Exhibit 5.1 hereto).

         24.1       Power of Attorney (see Page II-3).


                                     II-1
<PAGE>

                                  SIGNATURES

    Pursuant to the requirements of the Securities Act of 1933, the 
Registrant certifies that it has reasonable grounds to believe that it meets 
all of the requirements for filing on Form S-8 and has duly caused this 
Registration Statement to be signed on its behalf by the undersigned, 
thereunto duly authorized in the City of Mountain View, State of California 
on July 22, 1997.

                                       FUSION MEDICAL TECHNOLOGIES, INC.


                                       By:  /s/ PHILIP M. SAWYER
                                            ----------------------------------
                                            Philip M. Sawyer
                                            President, Chief Executive Officer
                                             and Acting Chief Financial Officer

                                       By:  /s/ WILLIAM J. VAUGHAN
                                            ----------------------------------
                                            William J. Vaughan
                                            Controller
                                            (Principal Accounting Officer)


                                     II-2
<PAGE>

                               POWER OF ATTORNEY

    KNOW ALL PERSONS BY THESE PRESENTS, that each person whose signature 
appears below constitutes and appoints Philip M. Sawyer and William J. 
Vaughan, jointly and severally, his attorney-in-fact, each with the power of 
substitution, for him in any and all capacities, to sign any amendments to 
this Registration Statement on Form S-8, and to file the same, with exhibits 
thereto and other documents in connection therewith, with the Securities and 
Exchange Commission, hereby ratifying and confirming all that each of said 
attorneys-in-fact, or his substitute or substitutes, may do or cause to be 
done by virtue hereof.

    Pursuant to the requirements of the Securities Act of 1933, this 
Registration Statement has been signed by the following persons in the 
capacities and on the date indicated.

<TABLE>
<CAPTION>
    SIGNATURE                     TITLE                                      DATE

<S>                               <C>                                        <C>
/s/ PHILIP M. SAWYER              President, Chief Executive                 July 22, 1997
-------------------------------   Officer, Acting Chief Financial Officer
  Philip M. Sawyer                and Director*

/s/ WILLIAM J. VAUGHAN            Controller                                 July 22, 1997
-------------------------------   (Principal Accounting Officer)
    William J. Vaughan

/s/ GORDON W. RUSSELL             Director*                                  July 22, 1997
-------------------------------
    Gordon W. Russell

/s/ OLAV B. BERGHEIM              Director*                                  July 22, 1997
-------------------------------
    Olav B. Bergheim

                                  Director*
-------------------------------
    Vaughn D. Bryson

/s/ DOUGLAS E. KELLY, M.D.        Director*                                  July 22, 1997
-------------------------------
    Douglas E. Kelly, M.D.

/s/ LAWRENCE G. MOHR, JR.         Director*                                  July 22, 1997
-------------------------------
    Lawrence G. Mohr, Jr.

/s/ RICHARD S. SCHNEIDER, PH.D.   Director*                                  July 22, 1997
-------------------------------
    Richard S. Schneider, Ph.D.
</TABLE>

*  The employee benefit plan being registered pursuant to this Registration
Statement are subject to administration by the Board of Directors of the
Registrant.


                                     II-3
<PAGE>

                               INDEX TO EXHIBITS


                                                                  Sequentially
Exhibit                                                             Numbered  
Number                       Description                              Page    
------------------------------------------------------------------------------
 5.1    Opinion of Wilson Sonsini Goodrich &
        Rosati, P.C., as to the legality of 
        securities being registered

23.1    Consent of Coopers & Lybrand L.L.P., Independent Auditors

23.2    Consent of Wilson Sonsini Goodrich & Rosati, P.C.                  
        (contained in Exhibit 5.1 hereto)

24.1    Power of Attorney                                                  
        (see Page II-3)
[{"type": "S-8", "sequence": "1", "description": "FORM S-8", "secsgml_size_bytes": 11543}]
{"company-data": {"conformed-name": "FUSION MEDICAL TECHNOLOGIES INC", "cik": "0001013466", "assigned-sic": "3841", "irs-number": "993177221", "state-of-incorporation": "DE", "fiscal-year-end": "1231"}, "filing-values": {"form-type": "S-8", "act": "33", "file-number": "333-32143", "film-number": "97645832"}, "business-address": {"street1": "1615 PLYMOUTH ST", "city": "MOUNTAIN VIEW", "state": "CA", "zip": "94043", "phone": "4159034000"}, "mail-address": {"street1": "1615 PLYMOUTH STREET", "city": "MOUNTAIN VIEW", "state": "CA", "zip": "94043"}}
As filed with the Securities and Exchange Commission on July 25, 1997
                                                    Registration No. 333-10043
------------------------------------------------------------------------------
------------------------------------------------------------------------------

                      SECURITIES AND EXCHANGE COMMISSION
                            Washington, D.C. 20549
                                       

                                   FORM S-8
                            REGISTRATION STATEMENT
                                     UNDER
                          THE SECURITIES ACT OF 1933 
                                       

                       FUSION MEDICAL TECHNOLOGIES, INC.
            (Exact name of registrant as specified in its charter)
Delaware                                                     94-3177221
           -------------------------------------                              ----------------------------
(State or other jurisdiction of incorporation or organization)             (I.R.S. Employer Identification No.)
1615 Plymouth Street
                        Mountain View, California 94043
                   (Address of principal executive offices)
                                       

                            1993 STOCK OPTION PLAN

                           (Full title of the Plans)
                                       

                               PHILIP M. SAWYER
                     President and Chief Executive Officer
                       Fusion Medical Technologies, Inc.
                             1615 Plymouth Street
                        Mountain View, California 94043
                                (415) 903-4000
           (Name, address and telephone number of agent for service)
                                       

                                   COPY TO:
                            John T. Sheridan, Esq.
                       Wilson Sonsini Goodrich & Rosati
                           Professional Corporation
                              650 Page Mill Road
                       Palo Alto, California 94304-1050
                                (415) 493-9300

------------------------------------------------------------------------------
------------------------------------------------------------------------------
--------------------------------------------------------------------------------------------------------------------
--------------------------------------------------------------------------------------------------------------------
                                          CALCULATION OF REGISTRATION FEE
--------------------------------------------------------------------------------------------------------------------
--------------------------------------------------------------------------------------------------------------------
                                                                Proposed            Proposed
        Title of                                                 Maximum             Maximum
       Securities                          Amount                Offering           Aggregate            Amount of
          to be                            to be                  Price             Offering            Registration
       Registered                        Registered             Per Share             Price                 Fee
1993 Stock Option Plan
Common Stock, $.001 par value(1)          300,000                 $4.375           $1,312,500(2)           $397.73
--------------------------------------------------------------------------------------------------------------------
--------------------------------------------------------------------------------------------------------------------
(1) In addition, pursuant to Rule 416(c) under the Securities Act of 1933, as
    amended, this Registration Statement also covers an indeterminate amount of
    interests to be offered or sold pursuant to the employee benefit plan
    described herein.

(2) Registration fee estimated in accordance with Rule 457(c) under the
    Securities Act of 1933, as amended, as to 300,000 shares of Common Stock,
    solely for the purpose of calculating the registration fee.  The
    computation is based upon the closing price of the Common Stock as reported
    on the Nasdaq National Market on July 22, 1997 because the price at which
    the options to be granted in the future may be exercised is not currently
    determinable.

                                       2
STATEMENT UNDER GENERAL INSTRUCTION E - REGISTRATION OF ADDITIONAL SECURITIES

    The Registrant previously filed one Registration Statement on Form S-8 
with the Securities and Exchange  Commission (SEC File No. 333-10043) (the 
"Previous Form S-8).  This Previous Form S-8 was filed in connection with the 
1993 Stock Option Plan, the 1996 Director Option Plan and the 1996 Employee 
Stock Purchase Plan (collectively the "Plans").  This Registration Statement 
registers additional shares of the Registrant's Common Stock to be issued 
pursuant to the Plans.  Accordingly, the content of the Previous Form S-8, 
including periodic reports that the Registrant filed after the Previous Form 
S-8 to maintain current information about the Registrant, are incorporated by 
reference into this Registration Statement pursuant to General Instruction E 
of Form S-8.  The reports the Registrant has most recently filed with the SEC 
are listed below:

    -    Annual Report on Form 10-K for the fiscal year ended December 31,
         1996, filed as of March 31, 1997.

    -    Quarterly Report on Form 10-Q for the quarterly period ended March 31,
         1997, filed as of May 15, 1997.

    -    Proxy Statement, filed as of April 28, 1997, in connection with the
         Annual Meeting of Shareholders held on May 22, 1997.

                                    PART II

              INFORMATION REQUIRED IN THE REGISTRATION STATEMENT

Item 8.  EXHIBITS.
         --------

         Exhibit 
         Number                          Document
         --------   ------------------------------------------------------

          5.1       Opinion of Wilson Sonsini Goodrich & Rosati, P.C., as 
                    to the legality of securities being registered.

         23.1       Consent of Coopers & Lybrand L.L.P., Independent Auditors.

         23.2       Consent of Wilson Sonsini Goodrich & Rosati, P.C. 
                    (contained in Exhibit 5.1 hereto).

         24.1       Power of Attorney (see Page II-3).

                                     II-1
SIGNATURES

    Pursuant to the requirements of the Securities Act of 1933, the 
Registrant certifies that it has reasonable grounds to believe that it meets 
all of the requirements for filing on Form S-8 and has duly caused this 
Registration Statement to be signed on its behalf by the undersigned, 
thereunto duly authorized in the City of Mountain View, State of California 
on July 22, 1997.

                                       FUSION MEDICAL TECHNOLOGIES, INC.

                                       By:  /s/ PHILIP M. SAWYER
                                            ----------------------------------
                                            Philip M. Sawyer
                                            President, Chief Executive Officer
                                             and Acting Chief Financial Officer

                                       By:  /s/ WILLIAM J. VAUGHAN
                                            ----------------------------------
                                            William J. Vaughan
                                            Controller
                                            (Principal Accounting Officer)

                                     II-2
POWER OF ATTORNEY

    KNOW ALL PERSONS BY THESE PRESENTS, that each person whose signature 
appears below constitutes and appoints Philip M. Sawyer and William J. 
Vaughan, jointly and severally, his attorney-in-fact, each with the power of 
substitution, for him in any and all capacities, to sign any amendments to 
this Registration Statement on Form S-8, and to file the same, with exhibits 
thereto and other documents in connection therewith, with the Securities and 
Exchange Commission, hereby ratifying and confirming all that each of said 
attorneys-in-fact, or his substitute or substitutes, may do or cause to be 
done by virtue hereof.

    Pursuant to the requirements of the Securities Act of 1933, this 
Registration Statement has been signed by the following persons in the 
capacities and on the date indicated.
SIGNATURE                     TITLE                                      DATE
/s/ PHILIP M. SAWYER              President, Chief Executive                 July 22, 1997
-------------------------------   Officer, Acting Chief Financial Officer
  Philip M. Sawyer                and Director*

/s/ WILLIAM J. VAUGHAN            Controller                                 July 22, 1997
-------------------------------   (Principal Accounting Officer)
    William J. Vaughan

/s/ GORDON W. RUSSELL             Director*                                  July 22, 1997
-------------------------------
    Gordon W. Russell

/s/ OLAV B. BERGHEIM              Director*                                  July 22, 1997
-------------------------------
    Olav B. Bergheim

                                  Director*
-------------------------------
    Vaughn D. Bryson

/s/ DOUGLAS E. KELLY, M.D.        Director*                                  July 22, 1997
-------------------------------
    Douglas E. Kelly, M.D.

/s/ LAWRENCE G. MOHR, JR.         Director*                                  July 22, 1997
-------------------------------
    Lawrence G. Mohr, Jr.

/s/ RICHARD S. SCHNEIDER, PH.D.   Director*                                  July 22, 1997
-------------------------------
    Richard S. Schneider, Ph.D.
*  The employee benefit plan being registered pursuant to this Registration
Statement are subject to administration by the Board of Directors of the
Registrant.

                                     II-3
INDEX TO EXHIBITS

                                                                  Sequentially
Exhibit                                                             Numbered  
Number                       Description                              Page    
------------------------------------------------------------------------------
 5.1    Opinion of Wilson Sonsini Goodrich &
        Rosati, P.C., as to the legality of 
        securities being registered

23.1    Consent of Coopers & Lybrand L.L.P., Independent Auditors

23.2    Consent of Wilson Sonsini Goodrich & Rosati, P.C.                  
        (contained in Exhibit 5.1 hereto)

24.1    Power of Attorney                                                  
        (see Page II-3)