<PAGE>

As filed with the Securities and Exchange Commission on February 11, 2000
                                          Registration No. 333-_____________

                       SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549

                                    FORM S-8

                             REGISTRATION STATEMENT
                                     UNDER
                           THE SECURITIES ACT OF 1933

                              McKESSON HBOC, INC.
             (Exact name of registrant as specified in its charter)

Delaware                                        94-3207296
(State or other jurisdiction of                 (I.R.S. Employer
incorporation or organization)                  Identification No.)

                    One Post Street
                    San Francisco, California                     94104
                    (Address of Principal Executive Offices)     (Zip Code)

                      1998  CANADIAN STOCK INCENTIVE PLAN
                              (Full Title of Plan)

Kristina Veaco             Ivan D. Meyerson
Senior Counsel and         Senior Vice President,
Assistant Secretary        General Counsel and Corporate Secretary
One Post Street            One Post Street
San Francisco, CA 94104    San Francisco, CA 94104

                    (Name and address of agents for service)
                                 (415) 983-8300
         (Telephone number, including area code, of agents for service)

The Registration Statement will become effective upon filing in accordance with
Rule 462 under the Securities Act of 1933.

                        CALCULATION OF REGISTRATION FEE

<TABLE>
<CAPTION>
Title of Securities to be    Amount to be        Proposed Maximum           Proposed Maximum             Amount of
 Registered                  Registered          Offering Price Per         Aggregate Offering        Registration Fee
                                                     Share(1)                   Price(1)
--------------------------------------------------------------------------------------------------------------------------
<S>                          <C>                       <C>                        <C>                        <C>
Common Stock par value
 $.01 per share              500,000                      $20.28                     10,140,000                 $2,680

--------------------------------------------------------------------------------------------------------------------------
Rights to purchase
 Preferred Stock (2)         500,000                      N/A                        N/A                          N/A

--------------------------------------------------------------------------------------------------------------------------
Total Registration Fee
                             N/A                          N/A                        N/A                         $2,680
--------------------------------------------------------------------------------------------------------------------------
</TABLE>

(1)  The price per share was calculated in accordance with Rule 457(c) and (h)
     for purposes of calculating the registration fee.  The maximum aggregate
     offering price was computed by multiplying 500,000 shares by the average of
     the high and low price of the stock on February 9, 2000.
(2)  Associated with the Common Stock are Rights to purchase Series A Preferred
     Stock that will not be exercisable or evidenced separately from the Common
     Stock prior to the occurrence of certain events.

Pursuant to Rule 416(a) this Registration Statement also covers such
indeterminate number of additional shares of Common Stock as is necessary to
eliminate any dilutive effect of any future stock split or stock dividend.  No
additional registration fee is required.
<PAGE>

                       EXPLANATORY NOTE AND INCORPORATION
                      OF CERTAIN INFORMATION BY REFERENCE
                 PURSUANT TO GENERAL INSTRUCTION E OF FORM S-8


     The Registration Statement is being filed for the purpose of increasing the
number of securities of the same class as other securities for which a
Registration Statement of the Registrant on Form S-8 relating to the same
employee benefit plan is effective.

     The Registrant's Form S-8 Registration Statement filed with the Securities
and Exchange Commission on March 20, 1998 (File No. 333-48339) is hereby
incorporated by reference.

     The following documents previously filed or to be filed by the Registrant
with the Securities and Exchange Commission are hereby incorporated by reference
in this Registration Statement:

     (a)  Annual Report on Form 10-K/A for the fiscal year ended March 31, 1999.

     (b) Quarterly Report on Form 10-Q for the quarter ended June 30, 1999.

     (c) Quarterly Report on Form 10-Q for the period ended September 30, 1999.

     (d)  Current Reports on Form 8-K with report dates of May 3, 1999, January
          28, 2000 and February 1, 2000

     (e) The description of Registrant's common stock contained in the
Registrant's Registration Statement on Form 10 (File No. 1-13252) and the Rights
Agreement dated as of October 21, 1994 and Amendment No. 1 thereto dated October
19, 1998 between the Registrant and First Chicago Trust Company of New York, as
Rights Agent, filed as Exhibits 4.1 and 4.2, respectively, to the Registrant's
Annual Report on Form 10-K/A for the fiscal year ended March, 31, 1999

     All documents subsequently filed by the Registrant pursuant to Sections 13
(a), 13 (c), 14 or 15 (d) of the Securities Exchange Act of 1934 shall be deemed
to be incorporated by reference in this Registration Statement and to be part
hereof from the date of filing of such documents until a post-effective
amendment of this Registration Statement is filed which indicates that all
securities being offered hereby have been sold or which deregisters all
securities than remaining unsold.

PART II.  INFORMATION REQUIRED IN REGISTRATION STATEMENT

Item 8.  Exhibits

Exhibit
No.            Description
---------------------------------------------------------

4         Rights Agreement dated as of October 21, 1994 and Amendment No. 1
          thereto dated October 19, 1998 between the Registrant and First
          Chicago Trust Company of New York, as Rights Agent, filed as Exhibits
          4.1 and 4.2 respectively, to the Registrant's Annual Report on Form
          10-K/A for the fiscal year ended March 31, 1999 and incorporated by
          reference herein.

5         Opinion of Ivan D. Meyerson, Senior Vice President, General Counsel
          and Corporate Secretary of the Registrant regarding the legality of
          the securities being offered.
<PAGE>

23.1      Consent of Ivan D. Meyerson, Senior Vice President, General Counsel
          and Corporate Secretary of the Registrant regarding the legality of
          the securities being offered.  (Included in Exhibit 5)

23.2      Consent of Deloitte & Touche LLP.

23.3      Consent of Arthur Andersen LLP.

24        Powers of Attorney pursuant to which certain officers and directors of
          the Registrant signed this Registration Statement.
<PAGE>

                                   SIGNATURES

     Pursuant to the requirements of the Securities Act of 1933, the Registrant
certifies that it has reasonable grounds to believe that it meets all of the
requirements for filing on Form S-8 and has duly caused this Registration
Statement to be signed on its behalf by the undersigned, thereunto duly
authorized, in the City of San Francisco, State of California, on the 10th day
of February 2000.

                                         McKESSON HBOC, INC.
                                         (Registrant)


                                         /s/Ivan D. Meyerson
                                         By:  Ivan D. Meyerson
                                         Senior Vice President,
                                         General Counsel and Secretary

          Pursuant to the requirements of the Securities Act of 1933, this
Registration Statement has been signed by the following persons in the
capacities indicated on the 20th day of January, 2000.

Signature and Title
  *John H. Hammergren, Co-President, and Co-Chief Executive Officer and Director
          (Co-Principal Executive Officer)
  *David L. Mahoney ,Co-President, and Co-Chief Executive Officer and Director
          (Co-Principal Executive Officer)
  *Heidi E. Yodowitz, Vice President, Controller and Acting Chief Financial
         Officer (Principal Financial and Accounting Officer)

  *Alfred C. Eckert, III, Director
  *Tully M. Friedman, Director
  *Alton F. Irby, III, Director
  *M. Christine Jacobs, Director
  *Gerald E. Mayo, Director
  *James V. Napier, Director
  *David S. Pottruck, Director
  *Carl E. Reichardt, Director
  *Alan J. Seelenfreund
           Chairman of the Board and Director
  *Jane E. Shaw, Director

*By:  /s/ Ivan D. Meyerson (Attorney-in-Fact)
          ----------------
          Ivan D. Meyerson
<PAGE>

                                 EXHIBIT INDEX


Exhibit
No.            Description
---------------------------------------------------------

4         Rights Agreement dated as of October 21, 1994 and Amendment No. 1
          thereto dated October 19, 1998 between the Registrant and First
          Chicago Trust Company of New York, as Rights Agent, filed as Exhibits
          4.1 and 4.2 respectively, to the Registrant's Annual Report on Form
          10-K/A for the fiscal year ended March 31, 1999 and incorporated by
          reference herein.

5         Opinion of Ivan D. Meyerson, Senior Vice President, General Counsel
          and Corporate Secretary of the Registrant regarding the legality of
          the securities being offered.

23.1      Consent of Ivan D. Meyerson, Senior Vice President, General Counsel
          and Corporate Secretary of the Registrant regarding the legality of
          the securities being offered.  (Included in Exhibit 5)

23.2      Consent of Deloitte & Touche LLP.

23.3      Consent of Arthur Andersen LLP.

24        Powers of Attorney pursuant to which certain officers and directors of
          the Registrant signed this Registration Statement.
[{"type": "S-8", "sequence": "1", "description": "MCKESSON HBOC - FORM S-8", "secsgml_size_bytes": 10341}]
{"company-data": {"conformed-name": "MCKESSON HBOC INC", "cik": "0000927653", "assigned-sic": "5122", "irs-number": "943207296", "state-of-incorporation": "DE", "fiscal-year-end": "0331"}, "filing-values": {"form-type": "S-8", "act": "33", "file-number": "333-30216", "film-number": "536406"}, "business-address": {"street1": "ONE POST ST", "street2": "MCKESSON PLAZA", "city": "SAN FRANCISCO", "state": "CA", "zip": "94104", "phone": "4159838300"}, "mail-address": {"street1": "ONE POST ST", "city": "SAN FRANCISCO", "state": "CA", "zip": "94104"}, "former-company": [{"former-conformed-name": "MCKESSON CORP", "date-changed": "19950209"}, {"former-conformed-name": "SP VENTURES INC", "date-changed": "19940728"}]}
As filed with the Securities and Exchange Commission on February 11, 2000
                                          Registration No. 333-_____________

                       SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549

                                    FORM S-8

                             REGISTRATION STATEMENT
                                     UNDER
                           THE SECURITIES ACT OF 1933

                              McKESSON HBOC, INC.
             (Exact name of registrant as specified in its charter)

Delaware                                        94-3207296
(State or other jurisdiction of                 (I.R.S. Employer
incorporation or organization)                  Identification No.)

                    One Post Street
                    San Francisco, California                     94104
                    (Address of Principal Executive Offices)     (Zip Code)

                      1998  CANADIAN STOCK INCENTIVE PLAN
                              (Full Title of Plan)

Kristina Veaco             Ivan D. Meyerson
Senior Counsel and         Senior Vice President,
Assistant Secretary        General Counsel and Corporate Secretary
One Post Street            One Post Street
San Francisco, CA 94104    San Francisco, CA 94104

                    (Name and address of agents for service)
                                 (415) 983-8300
         (Telephone number, including area code, of agents for service)

The Registration Statement will become effective upon filing in accordance with
Rule 462 under the Securities Act of 1933.

                        CALCULATION OF REGISTRATION FEE
Title of Securities to be    Amount to be        Proposed Maximum           Proposed Maximum             Amount of
 Registered                  Registered          Offering Price Per         Aggregate Offering        Registration Fee
                                                     Share(1)                   Price(1)
--------------------------------------------------------------------------------------------------------------------------
Common Stock par value
 $.01 per share              500,000                      $20.28                     10,140,000                 $2,680

--------------------------------------------------------------------------------------------------------------------------
Rights to purchase
 Preferred Stock (2)         500,000                      N/A                        N/A                          N/A

--------------------------------------------------------------------------------------------------------------------------
Total Registration Fee
                             N/A                          N/A                        N/A                         $2,680
--------------------------------------------------------------------------------------------------------------------------
(1)  The price per share was calculated in accordance with Rule 457(c) and (h)
     for purposes of calculating the registration fee.  The maximum aggregate
     offering price was computed by multiplying 500,000 shares by the average of
     the high and low price of the stock on February 9, 2000.
(2)  Associated with the Common Stock are Rights to purchase Series A Preferred
     Stock that will not be exercisable or evidenced separately from the Common
     Stock prior to the occurrence of certain events.

Pursuant to Rule 416(a) this Registration Statement also covers such
indeterminate number of additional shares of Common Stock as is necessary to
eliminate any dilutive effect of any future stock split or stock dividend.  No
additional registration fee is required.
EXPLANATORY NOTE AND INCORPORATION
                      OF CERTAIN INFORMATION BY REFERENCE
                 PURSUANT TO GENERAL INSTRUCTION E OF FORM S-8

     The Registration Statement is being filed for the purpose of increasing the
number of securities of the same class as other securities for which a
Registration Statement of the Registrant on Form S-8 relating to the same
employee benefit plan is effective.

     The Registrant's Form S-8 Registration Statement filed with the Securities
and Exchange Commission on March 20, 1998 (File No. 333-48339) is hereby
incorporated by reference.

     The following documents previously filed or to be filed by the Registrant
with the Securities and Exchange Commission are hereby incorporated by reference
in this Registration Statement:

     (a)  Annual Report on Form 10-K/A for the fiscal year ended March 31, 1999.

     (b) Quarterly Report on Form 10-Q for the quarter ended June 30, 1999.

     (c) Quarterly Report on Form 10-Q for the period ended September 30, 1999.

     (d)  Current Reports on Form 8-K with report dates of May 3, 1999, January
          28, 2000 and February 1, 2000

     (e) The description of Registrant's common stock contained in the
Registrant's Registration Statement on Form 10 (File No. 1-13252) and the Rights
Agreement dated as of October 21, 1994 and Amendment No. 1 thereto dated October
19, 1998 between the Registrant and First Chicago Trust Company of New York, as
Rights Agent, filed as Exhibits 4.1 and 4.2, respectively, to the Registrant's
Annual Report on Form 10-K/A for the fiscal year ended March, 31, 1999

     All documents subsequently filed by the Registrant pursuant to Sections 13
(a), 13 (c), 14 or 15 (d) of the Securities Exchange Act of 1934 shall be deemed
to be incorporated by reference in this Registration Statement and to be part
hereof from the date of filing of such documents until a post-effective
amendment of this Registration Statement is filed which indicates that all
securities being offered hereby have been sold or which deregisters all
securities than remaining unsold.

PART II.  INFORMATION REQUIRED IN REGISTRATION STATEMENT

Item 8.  Exhibits

Exhibit
No.            Description
---------------------------------------------------------

4         Rights Agreement dated as of October 21, 1994 and Amendment No. 1
          thereto dated October 19, 1998 between the Registrant and First
          Chicago Trust Company of New York, as Rights Agent, filed as Exhibits
          4.1 and 4.2 respectively, to the Registrant's Annual Report on Form
          10-K/A for the fiscal year ended March 31, 1999 and incorporated by
          reference herein.

5         Opinion of Ivan D. Meyerson, Senior Vice President, General Counsel
          and Corporate Secretary of the Registrant regarding the legality of
          the securities being offered.
23.1      Consent of Ivan D. Meyerson, Senior Vice President, General Counsel
          and Corporate Secretary of the Registrant regarding the legality of
          the securities being offered.  (Included in Exhibit 5)

23.2      Consent of Deloitte & Touche LLP.

23.3      Consent of Arthur Andersen LLP.

24        Powers of Attorney pursuant to which certain officers and directors of
          the Registrant signed this Registration Statement.
SIGNATURES

     Pursuant to the requirements of the Securities Act of 1933, the Registrant
certifies that it has reasonable grounds to believe that it meets all of the
requirements for filing on Form S-8 and has duly caused this Registration
Statement to be signed on its behalf by the undersigned, thereunto duly
authorized, in the City of San Francisco, State of California, on the 10th day
of February 2000.

                                         McKESSON HBOC, INC.
                                         (Registrant)

                                         /s/Ivan D. Meyerson
                                         By:  Ivan D. Meyerson
                                         Senior Vice President,
                                         General Counsel and Secretary

          Pursuant to the requirements of the Securities Act of 1933, this
Registration Statement has been signed by the following persons in the
capacities indicated on the 20th day of January, 2000.

Signature and Title
  *John H. Hammergren, Co-President, and Co-Chief Executive Officer and Director
          (Co-Principal Executive Officer)
  *David L. Mahoney ,Co-President, and Co-Chief Executive Officer and Director
          (Co-Principal Executive Officer)
  *Heidi E. Yodowitz, Vice President, Controller and Acting Chief Financial
         Officer (Principal Financial and Accounting Officer)

  *Alfred C. Eckert, III, Director
  *Tully M. Friedman, Director
  *Alton F. Irby, III, Director
  *M. Christine Jacobs, Director
  *Gerald E. Mayo, Director
  *James V. Napier, Director
  *David S. Pottruck, Director
  *Carl E. Reichardt, Director
  *Alan J. Seelenfreund
           Chairman of the Board and Director
  *Jane E. Shaw, Director

*By:  /s/ Ivan D. Meyerson (Attorney-in-Fact)
          ----------------
          Ivan D. Meyerson
EXHIBIT INDEX

Exhibit
No.            Description
---------------------------------------------------------

4         Rights Agreement dated as of October 21, 1994 and Amendment No. 1
          thereto dated October 19, 1998 between the Registrant and First
          Chicago Trust Company of New York, as Rights Agent, filed as Exhibits
          4.1 and 4.2 respectively, to the Registrant's Annual Report on Form
          10-K/A for the fiscal year ended March 31, 1999 and incorporated by
          reference herein.

5         Opinion of Ivan D. Meyerson, Senior Vice President, General Counsel
          and Corporate Secretary of the Registrant regarding the legality of
          the securities being offered.

23.1      Consent of Ivan D. Meyerson, Senior Vice President, General Counsel
          and Corporate Secretary of the Registrant regarding the legality of
          the securities being offered.  (Included in Exhibit 5)

23.2      Consent of Deloitte & Touche LLP.

23.3      Consent of Arthur Andersen LLP.

24        Powers of Attorney pursuant to which certain officers and directors of
          the Registrant signed this Registration Statement.