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<P ALIGN="CENTER"><FONT SIZE=2><B>As filed with the Securities and Exchange Commission on February&nbsp;1, 2002  </B></FONT></P>

<P ALIGN="RIGHT"><FONT SIZE=2><B> Registration No.&nbsp;333-&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</B></FONT></P>

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<P ALIGN="CENTER"><FONT SIZE=4><B>SECURITIES AND EXCHANGE COMMISSION<BR>  </B></FONT><FONT SIZE=2><B>WASHINGTON, DC 20549  </B></FONT></P>

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<P ALIGN="CENTER"><FONT SIZE=4><B>FORM S-8<BR>  </B></FONT><FONT SIZE=2><B>REGISTRATION STATEMENT<BR>
UNDER<BR>
THE SECURITIES ACT OF 1933  </B></FONT></P>

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<P ALIGN="CENTER"><FONT SIZE=4><B>MacroPore,&nbsp;Inc.<BR>  </B></FONT><FONT SIZE=2>(Exact name of registrant as specified in its charter) </FONT></P>

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<TD WIDTH="50%" ALIGN="CENTER"><FONT SIZE=2><B>Delaware</B></FONT></TD>
<TD WIDTH="50%" ALIGN="CENTER"><FONT SIZE=2><B>330-827-593</B></FONT></TD>
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<TD WIDTH="50%" ALIGN="CENTER" VALIGN="TOP"><FONT SIZE=2>(State or other jurisdiction of incorporation<BR>
or organization)</FONT></TD>
<TD WIDTH="50%" ALIGN="CENTER" VALIGN="TOP"><FONT SIZE=2>(I.R.S. Employer Identification No.)</FONT></TD>
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<TD WIDTH="50%" ALIGN="CENTER"><FONT SIZE=2>&nbsp;</FONT></TD>
<TD WIDTH="50%"><FONT SIZE=2>&nbsp;</FONT></TD>
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<TD WIDTH="50%" ALIGN="CENTER"><BR><FONT SIZE=2><B>6740 Top Gun Street<BR>
San Diego, CA</B></FONT></TD>
<TD WIDTH="50%" ALIGN="CENTER"><FONT SIZE=2><B><BR>
&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<BR>
92121</B></FONT></TD>
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<TD WIDTH="50%" ALIGN="CENTER"><FONT SIZE=2>(Address of principal executive offices)</FONT></TD>
<TD WIDTH="50%" ALIGN="CENTER"><FONT SIZE=2>(Zip Code)</FONT></TD>
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<P ALIGN="CENTER"><FONT SIZE=5><B>MacroPore,&nbsp;Inc. Amended and Restated<BR>
1997 Stock Option and Stock Purchase Plan<BR>  </B></FONT><FONT SIZE=2>(Full title of the plan) </FONT></P>

<P ALIGN="CENTER"><FONT SIZE=2><B>Jon Soneff, Esq.<BR>
MacroPore,&nbsp;Inc.<BR>
6740 Top Gun Street<BR>
San Diego, CA 92121<BR>
(858) 458-0900<BR>  </B></FONT><FONT SIZE=2>(Name, address and telephone number, including area code, of agent for service) </FONT></P>

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<P ALIGN="CENTER"><FONT SIZE=2><I>Copies of all communications to:  </I></FONT></P>

<P ALIGN="CENTER"><FONT SIZE=2><B>Peter P. Wallace, Esq.<BR>
Ingrid A. Myers, Esq.<BR>
Morgan, Lewis&nbsp;&amp; Bockius LLP<BR>
300 South Grand Avenue, 22nd Floor<BR>
Los Angeles, CA 90071<BR>
(213)&nbsp;612-2500  </B></FONT></P>

<P ALIGN="CENTER"><FONT SIZE=2><B> CALCULATION OF REGISTRATION FEE  </B></FONT></P>

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<TD WIDTH="34%" ALIGN="CENTER" VALIGN="BOTTOM"><FONT SIZE=1><B>Title of Securities<BR>
to be Registered</B></FONT></TD>
<TD WIDTH="1%" VALIGN="BOTTOM"><FONT SIZE=1>&nbsp;</FONT></TD>
<TD WIDTH="19%" ALIGN="CENTER" VALIGN="BOTTOM"><FONT SIZE=1><B>Amount to<BR>
be Registered(1)</B></FONT></TD>
<TD WIDTH="1%" VALIGN="BOTTOM"><FONT SIZE=1>&nbsp;</FONT></TD>
<TD WIDTH="14%" ALIGN="CENTER" VALIGN="BOTTOM"><FONT SIZE=1><B>Proposed Maximum<BR>
Offering Price<BR>
Per Share(2)</B></FONT></TD>
<TD WIDTH="1%" VALIGN="BOTTOM"><FONT SIZE=1>&nbsp;</FONT></TD>
<TD WIDTH="14%" ALIGN="CENTER" VALIGN="BOTTOM"><FONT SIZE=1><B>Proposed Maximum<BR>
Aggregate<BR>
Offering Price(2)</B></FONT></TD>
<TD WIDTH="1%" VALIGN="BOTTOM"><FONT SIZE=1>&nbsp;</FONT></TD>
<TD WIDTH="14%" ALIGN="CENTER" VALIGN="BOTTOM"><FONT SIZE=1><B>Amount of<BR>
Registration Fee</B></FONT></TD>
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<TD WIDTH="34%"><FONT SIZE=2>Common stock, par value $.01 per share</FONT></TD>
<TD WIDTH="1%"><FONT SIZE=2>&nbsp;</FONT></TD>
<TD WIDTH="19%" ALIGN="CENTER"><FONT SIZE=2>5,733,099 shares</FONT></TD>
<TD WIDTH="1%"><FONT SIZE=2>&nbsp;</FONT></TD>
<TD WIDTH="14%" ALIGN="CENTER"><FONT SIZE=2>$3.9971</FONT></TD>
<TD WIDTH="1%"><FONT SIZE=2>&nbsp;</FONT></TD>
<TD WIDTH="14%" ALIGN="CENTER"><FONT SIZE=2>$22,915,670</FONT></TD>
<TD WIDTH="1%"><FONT SIZE=2>&nbsp;</FONT></TD>
<TD WIDTH="14%" ALIGN="CENTER"><FONT SIZE=2>$2,108</FONT></TD>
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<DL compact>
<DT style='margin-bottom:-11pt;'><FONT SIZE=2>(1)</FONT></DT><DD><FONT SIZE=2>This
registration statement includes shares of common stock of MacroPore,&nbsp;Inc. which are offered or sold pursuant to the plan named above. Pursuant to Rule&nbsp;416(a) of the
Securities Act of 1933, this registration statement also includes any additional shares of common stock which are offered or issued under the plan to prevent dilution resulting from stock splits,
stock dividends or similar transactions.
<BR><BR></FONT></DD><DT style='margin-bottom:-11pt;'><FONT SIZE=2>(2)</FONT></DT><DD><FONT SIZE=2>With
respect to grants previously issued under the plan, the actual exercise price has been used to compute the maximum offering price pursuant to Rule&nbsp;457(h)(1). For the
remaining shares issuable under the plan, the maximum offering price is estimated pursuant to paragraph&nbsp;(c) and (h)&nbsp;of Rule&nbsp;457, solely for the purpose of calculating the
registration fee, based upon the average of the reported high and low sales prices for a share of common stock of MacroPore,&nbsp;Inc. on January&nbsp;28, 2002 as reported on the </FONT> <FONT SIZE=2><I>Neuer Markt </I></FONT><FONT SIZE=2>of the
Frankfurt Stock Exchange, which average was 3.90 Euros, or $3.3525 per share based on the exchange rate as of that date. </FONT></DD></DL>
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<BR></FONT><FONT SIZE=2><B>PART II<BR>  <BR>    INFORMATION REQUIRED IN THE REGISTRATION STATEMENT    <BR>  </B></FONT></P>


<P><FONT SIZE=2><A
NAME="da1094_item_3._incorporation_of_documents_by_reference."> </A>
<A NAME="toc_da1094_2"> </A></FONT> <FONT SIZE=2><B>Item 3. Incorporation of Documents by Reference.    <BR>  </B></FONT></P>

<P><FONT SIZE=2>The
following documents filed by MacroPore,&nbsp;Inc. with the Commission are incorporated by reference into this registration statement. As used in this registration statement, the terms
"MacroPore," "we," "us," or "our" or similar terms refer to MacroPore,&nbsp;Inc. </FONT></P>

<UL>
<DL compact>
<DT style='margin-bottom:-11pt;'><FONT SIZE=2>1.</FONT></DT><DD><FONT SIZE=2>Our
registration statement on Form&nbsp;10 filed pursuant to Section&nbsp;12(g) of the Securities and Exchange Act of 1934 (the "Exchange Act") on March&nbsp;30, 2001, as
amended, Commission File No.&nbsp;000-32501;
<BR><BR></FONT></DD><DT style='margin-bottom:-11pt;'><FONT SIZE=2>2.</FONT></DT><DD><FONT SIZE=2>All
reports we have filed pursuant to Sections 13(a) or 15(d) of the Exchange Act since May&nbsp;31, 2001 when our Form&nbsp;10 referred to in (1)&nbsp;above became effective;
and
<BR><BR></FONT></DD><DT style='margin-bottom:-11pt;'><FONT SIZE=2>3.</FONT></DT><DD><FONT SIZE=2>The
description of our shares of common stock contained in the section entitled "Description of Capital Stock" in our Form&nbsp;10 referenced in (1)&nbsp;above. </FONT></DD></DL>
</UL>

<P><FONT SIZE=2>All
reports and other documents subsequently filed by us pursuant to Sections 13(a), 13(c), 14 and 15(d) of the Exchange Act after the date of this registration statement, but prior to the filing of a
post-effective amendment to this registration statement that indicates all of the securities offered by this registration statement have been sold or which deregisters all such securities
then remaining unsold, shall be deemed to be incorporated by reference into this registration statement. Each document incorporated by reference into this registration statement shall be deemed to be
a part of this registration statement from the date of the filing of such document with the Commission until the information contained therein is superseded or updated by any subsequently filed
document which is
incorporated by reference into this registration statement or by any document which constitutes part of the prospectus relating to our Amended and Restated 1997 Stock Option and Stock Purchase Plan
and meets the requirements of Section&nbsp;10(a) of the Securities Act. </FONT></P>

<P><FONT SIZE=2>Any
statement contained herein or in a document all or a portion of which is incorporated by reference herein shall be deemed to be modified or superseded for purposes of this registration statement
to the extent that a statement contained in this registration statement or in any other subsequently filed document that is also incorporated by reference herein modifies or supersedes such statement.
Any such statement so modified or superseded shall not be deemed, except as so modified or superseded, to constitute a part of this registration statement. </FONT></P>


<P><FONT SIZE=2><A
NAME="da1094_item_4._description_of_securities."> </A>
<A NAME="toc_da1094_3"> </A>
<BR></FONT><FONT SIZE=2><B>Item 4. Description of Securities.    <BR>  </B></FONT></P>

<P><FONT SIZE=2>Not
Applicable. </FONT></P>

<P><FONT SIZE=2><A
NAME="da1094_item_5._interests_of_named_experts_and_counsel."> </A>
<A NAME="toc_da1094_4"> </A>
<BR></FONT><FONT SIZE=2><B>Item 5. Interests of Named Experts and Counsel.    <BR>  </B></FONT></P>

<P><FONT SIZE=2>Not
Applicable. </FONT></P>

<P><FONT SIZE=2><A
NAME="da1094_item_6._indemnification_of_directors_and_officers."> </A>
<A NAME="toc_da1094_5"> </A>
<BR></FONT><FONT SIZE=2><B>Item 6. Indemnification of Directors and Officers.    <BR>  </B></FONT></P>


<P><FONT SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Section&nbsp;145 of the General Corporation Law of the State of Delaware permits us, under specified circumstances, to indemnify our directors, officers,
employees or agents against expenses, including attorney's fees, judgments, fines and amounts paid in settlements actually and reasonably incurred by them in connection with any action, suit or
proceeding brought by third parties by reason of the fact that they were or are our directors, officers, employees or agents or were or are serving at our request as a director, officer, employee or
agent of another corporation, if such directors, officers, employees, or agents acted in good faith and in a manner they reasonably believed to be in or not opposed to our </FONT></P>

<P ALIGN="CENTER"><FONT SIZE=2>1</FONT></P>

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best interests of the corporation and, with respect to any criminal action or proceeding, had no reasonable cause to believe their conduct was unlawful. In a derivative action, one by or in our
right, indemnification may be made only for expenses actually and reasonably incurred by our directors,
officers, employees or agents in connection with the defense or settlement of an action or suit, and only with respect to a matter as to which they acted in good faith and in a manner they reasonably
believed to be in or not opposed to our best interests, except that no indemnification shall be made in respect of any claim, issue or matter as to which such person shall be adjudicated to be liable
to us unless the court in which the action or suit was brought determines upon application that the defendant directors, officers, employees, or agents are fairly and reasonably entitled to
indemnification for such expenses in view of all of the circumstances of the case, despite such adjudication of liability. We may pay expenses, including attorney's fees, incurred by an officer or
director in defending any civil, criminal, administrative or investigative action, suit or proceeding in advance of the final disposition of such action, suit or proceeding upon receipt of an
undertaking by or on behalf of such director or officer to repay such amount if a court ultimately determines that he is not entitled to be indemnified by us. </FONT></P>

<P><FONT SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Article&nbsp;VI
of our by-laws require us to indemnify our current or former directors and officers and may indemnify other corporate agents, to the fullest extent
authorized or permitted by applicable law. Subject to applicable law and the provisions of our Amended and Restated Certificate of Incorporation regarding indemnification by us, we may indemnify an
employee or agent to the extent that the board of directors or our stockholders may determine in its or their discretion. </FONT></P>

<P><FONT SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Article&nbsp;VII
of our Amended and Restated Certificate of Incorporation provides that our directors will not be personally liable to us or our stockholders for monetary damages
resulting from a breach of fiduciary duty as a director, except for (a)&nbsp;any breach of the director's duty of loyalty to us or our stockholders, (b)&nbsp;acts or omissions not in good faith or
which involve intentional misconduct or a knowing violation of law, (c)&nbsp;liability under Section&nbsp;174 of the General Corporation Law of the State of Delaware, or (d)&nbsp;any transaction
from which a director derived an improper personal benefit. This limitation of liability does not apply to the responsibility or liability of our directors pursuant to any criminal statute, nor does
it relieve the directors from payment of taxes pursuant to federal, state or local law. </FONT></P>

<P><FONT SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;We
maintain an insurance policy containing customary terms and conditions for the purpose of insuring our directors and officers against certain losses incurred by them as a result of
claims based upon their actions or statements, including omissions to act or make statements, as directors and officers, which may cover liabilities under the Securities Act. </FONT></P>


<P><FONT SIZE=2><A
NAME="da1094_item_7._exemption_from_registration_claimed."> </A>
<A NAME="toc_da1094_6"> </A>
<BR></FONT><FONT SIZE=2><B>Item 7. Exemption from Registration Claimed.    <BR>  </B></FONT></P>

<P><FONT SIZE=2>Not
Applicable. </FONT></P>

<P><FONT SIZE=2><A
NAME="da1094_item_8._exhibits."> </A>
<A NAME="toc_da1094_7"> </A>
<BR></FONT><FONT SIZE=2><B>Item 8. Exhibits.    <BR>  </B></FONT></P>

<P><FONT SIZE=2>The
following exhibits are filed herewith or incorporated by reference as part of this registration statement: </FONT></P>

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<TH WIDTH="9%" ALIGN="CENTER"><FONT SIZE=1><B>Exhibit<BR>
No.</B></FONT><HR NOSHADE></TH>
<TH WIDTH="3%"><FONT SIZE=1>&nbsp;</FONT></TH>
<TH WIDTH="88%" ALIGN="CENTER"><FONT SIZE=1><B>Description</B></FONT><HR NOSHADE></TH>
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5.1</FONT></TD>
<TD WIDTH="3%"><FONT SIZE=2><BR>&nbsp;</FONT></TD>
<TD WIDTH="88%"><FONT SIZE=2><BR>
Opinion of Morgan, Lewis &amp; Bockius LLP.</FONT></TD>
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23.1</FONT></TD>
<TD WIDTH="3%"><FONT SIZE=2><BR>&nbsp;</FONT></TD>
<TD WIDTH="88%"><FONT SIZE=2><BR>
Consent of Arthur Andersen LLP, Independent Public Accountants.</FONT></TD>
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23.2</FONT></TD>
<TD WIDTH="3%"><FONT SIZE=2><BR>&nbsp;</FONT></TD>
<TD WIDTH="88%"><FONT SIZE=2><BR>
Consent of PricewaterhouseCoopers LLP, Independent Accountants</FONT></TD>
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24.1</FONT></TD>
<TD WIDTH="3%"><FONT SIZE=2><BR>&nbsp;</FONT></TD>
<TD WIDTH="88%"><FONT SIZE=2><BR>
Power of Attorney (contained in the signature page).</FONT></TD>
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<P ALIGN="CENTER"><FONT SIZE=2>2</FONT></P>

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<P><FONT SIZE=2><A
NAME="da1094_item_9._undertakings."> </A>
<A NAME="toc_da1094_8"> </A>
<BR></FONT><FONT SIZE=2><B>Item 9. Undertakings.    <BR>  </B></FONT></P>

<P><FONT SIZE=2>The
undersigned registrant hereby undertakes: </FONT></P>


<P><FONT SIZE=2>(a)
(1) To file, during any period in which offers or sales are being made, a post-effective amendment to this registration statement: </FONT></P>

<UL>
<DL compact>
<DT style='margin-bottom:-11pt;'><FONT SIZE=2>(i)</FONT></DT><DD><FONT SIZE=2>To
include any prospectus required by Section&nbsp;10(a)(3) of the Securities Act;
<BR><BR></FONT></DD><DT style='margin-bottom:-11pt;'><FONT SIZE=2>(ii)</FONT></DT><DD><FONT SIZE=2>To
reflect in the prospectus any facts or events arising after the effective date of this registration statement, or the most recent
post-effective amendment thereof, which, individually or in the aggregate, represent a fundamental change in the information set forth in this registration statement. Notwithstanding the
foregoing, any increase or decrease in volume of securities offered, if the total dollar value of securities offered would not exceed that which was registered, and any deviation from the low or high
end of the estimated maximum offering range may be reflected in the form of prospectus filed with the Commission pursuant to Rule&nbsp;424(b) if, in the aggregate, the changes in volume and price
represent no more than 20&nbsp;percent change in the maximum aggregate offering price set forth in the "Calculation of Registration Fee" table in the effective registration statement;
<BR><BR></FONT></DD><DT style='margin-bottom:-11pt;'><FONT SIZE=2>(iii)</FONT></DT><DD><FONT SIZE=2>To
include any material information with respect to the plan of distribution not previously disclosed in this registration statement or any material
change to such information in this registration statement. </FONT></DD></DL>
</UL>

<P><FONT SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(2)&nbsp;&nbsp;That,
for the purpose of determining any liability under the Securities Act, each such post-effective amendment shall be deemed to be a new registration
statement relating to the securities offered therein, and the offering of such securities at that time shall be deemed to be the initial </FONT><FONT SIZE=2><I>bona fide</I></FONT><FONT SIZE=2>
offering thereof. </FONT></P>

<P><FONT SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(3)&nbsp;&nbsp;To
remove from registration by means of a post-effective amendment any of the securities being registered which remain unsold at the termination of the
offering. </FONT></P>

<P><FONT SIZE=2>(b)
The undersigned registrant hereby undertakes that, for purposes of determining any liability under the Securities Act, each filing of the registrant's annual report pursuant to
Section&nbsp;13(a) or Section&nbsp;15(d) of the Exchange Act that is incorporated by reference in the registration statement shall be deemed to be a new registration statement relating to the
securities offered therein, and the offering of such securities at that time shall be deemed to be the initial </FONT><FONT SIZE=2><I>bona fide</I></FONT><FONT SIZE=2> offering thereof. </FONT></P>

<P><FONT SIZE=2>(c)
Insofar as indemnification for liabilities arising under the Securities Act may be permitted to directors, officers and controlling persons of the registrant pursuant to the foregoing provisions,
or otherwise, the registrant has been advised that in the opinion of the Commission such indemnification is against public policy as expressed in the Act and is, therefore, unenforceable. In the event
that a claim for indemnification against such liabilities (other than the payment by the registrant of expenses incurred or paid by a director, officer or controlling person of the registrant in the
successful defense of any action, suit or proceeding) is asserted by such director, officer or controlling person in connection with the securities being registered, the registrant will, unless in the
opinion of its counsel the matter has been settled by controlling precedent, submit to a court of appropriate jurisdiction the question whether such indemnification by it is against public policy as
expressed in the Act and will be governed by the final adjudication of such issue. </FONT></P>

<P ALIGN="CENTER"><FONT SIZE=2>3</FONT></P>

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<A NAME="toc_jc1094_1"> </A>
<BR></FONT><FONT SIZE=2><B>SIGNATURES    <BR>  </B></FONT></P>

<P><FONT SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Pursuant to the requirements of the Securities Act of 1933, the registrant certifies that it has reasonable grounds to believe that it meets all of the
requirements for filing on Form&nbsp;S-8 and has duly caused this registration statement to be signed on its behalf by the undersigned, thereunto duly authorized, in the city of San
Diego, state of California, on this 24<SUP>th</SUP> day of January, 2002. </FONT></P>

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<TD COLSPAN=2><FONT SIZE=2><B>MACROPORE, INC.</B></FONT></TD>
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<TD WIDTH="47%"><FONT SIZE=2><BR>
&nbsp;</FONT></TD>
<TD WIDTH="3%"><FONT SIZE=2><BR>&nbsp;</FONT></TD>
<TD WIDTH="4%"><FONT SIZE=2><BR>
By:</FONT></TD>
<TD WIDTH="46%"><FONT SIZE=2><BR>
/s/&nbsp;&nbsp;</FONT><FONT SIZE=2>CHRISTOPHER J. CALHOUN</FONT><FONT SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</FONT><HR NOSHADE><FONT SIZE=2> Christopher J. Calhoun<BR>
Chief Executive Officer, Vice-Chairman, Secretary</FONT></TD>
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<P><FONT SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Pursuant
to the requirements of the Securities Act of 1933, this registration statement has been signed by the following persons in the capacities and on the date indicated. Each person
whose signature appears below hereby constitutes and appoints Christopher J. Calhoun, his true and lawful attorney-in-fact and agent, with full power of substitution and
re-substitution, for him and in his name, place and stead, in any and all capacities, to sign any and all amendments, including post-effective amendments, and supplements to
this registration statement, and to file the same with all the exhibits thereto, and other documents in connection therewith with the Securities and Exchange Commission, granting unto said
attorney-in-fact and agent, full power and authority to do and perform any and all acts and things requisite and necessary to be done, as fully as to all intents and purposes
as he might or could do in person, hereby ratifying and confirming all that said attorney-in-fact and agents of said attorney-in-fact, or his
substitute, may lawfully do or cause to be done by virtue hereof. </FONT></P>

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<TH WIDTH="2%"><FONT SIZE=1>&nbsp;</FONT></TH>
<TH WIDTH="29%" ALIGN="CENTER"><FONT SIZE=1><B>Title</B></FONT><HR NOSHADE></TH>
<TH WIDTH="2%"><FONT SIZE=1>&nbsp;</FONT></TH>
<TH WIDTH="21%" ALIGN="CENTER"><FONT SIZE=1><B>Date</B></FONT><HR NOSHADE></TH>
</TR>
<TR VALIGN="TOP">
<TD WIDTH="45%" ALIGN="CENTER" VALIGN="CENTER"><BR><FONT SIZE=2>&nbsp;</FONT></TD>
<TD WIDTH="2%" VALIGN="CENTER"><FONT SIZE=2><BR>&nbsp;</FONT></TD>
<TD WIDTH="29%" VALIGN="CENTER"><FONT SIZE=2><BR>
&nbsp;</FONT></TD>
<TD WIDTH="2%" VALIGN="CENTER"><FONT SIZE=2><BR>&nbsp;</FONT></TD>
<TD WIDTH="21%" VALIGN="CENTER"><FONT SIZE=2><BR>
&nbsp;</FONT></TD>
</TR>
<TR VALIGN="TOP">
<TD WIDTH="45%" ALIGN="CENTER" VALIGN="CENTER"><FONT SIZE=2><BR>
/s/&nbsp;&nbsp;</FONT><FONT SIZE=2>MARSHALL G. COX</FONT><FONT SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</FONT><HR NOSHADE><FONT SIZE=2> Marshall G. Cox</FONT></TD>
<TD WIDTH="2%" VALIGN="CENTER"><FONT SIZE=2><BR>&nbsp;</FONT></TD>
<TD WIDTH="29%" VALIGN="CENTER"><FONT SIZE=2><BR>
Chairman of the Board and Director</FONT></TD>
<TD WIDTH="2%" VALIGN="CENTER"><FONT SIZE=2><BR>&nbsp;</FONT></TD>
<TD WIDTH="21%" ALIGN="CENTER" VALIGN="CENTER"><FONT SIZE=2><BR>
January 24, 2002</FONT></TD>
</TR>
<TR VALIGN="TOP">
<TD WIDTH="45%" ALIGN="CENTER" VALIGN="CENTER"><FONT SIZE=2><BR>
/s/&nbsp;&nbsp;</FONT><FONT SIZE=2>CHRISTOPHER J. CALHOUN</FONT><FONT SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</FONT><HR NOSHADE><FONT SIZE=2> Christopher J. Calhoun</FONT></TD>
<TD WIDTH="2%" VALIGN="CENTER"><FONT SIZE=2><BR>&nbsp;</FONT></TD>
<TD WIDTH="29%" VALIGN="CENTER"><FONT SIZE=2><BR>
Chief Executive Officer, Vice-Chairman, Secretary and Director</FONT></TD>
<TD WIDTH="2%" VALIGN="CENTER"><FONT SIZE=2><BR>&nbsp;</FONT></TD>
<TD WIDTH="21%" ALIGN="CENTER" VALIGN="CENTER"><FONT SIZE=2><BR>
January 24, 2002</FONT></TD>
</TR>
<TR VALIGN="BOTTOM">
<TD WIDTH="45%" ALIGN="CENTER" VALIGN="CENTER"><FONT SIZE=2><BR>
/s/&nbsp;&nbsp;</FONT><FONT SIZE=2>MICHAEL SIMPSON</FONT><FONT SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</FONT><HR NOSHADE><FONT SIZE=2> Michael Simpson</FONT></TD>
<TD WIDTH="2%" VALIGN="CENTER"><FONT SIZE=2><BR>&nbsp;</FONT></TD>
<TD WIDTH="29%" VALIGN="CENTER"><FONT SIZE=2><BR>
President and Director</FONT></TD>
<TD WIDTH="2%" VALIGN="CENTER"><FONT SIZE=2><BR>&nbsp;</FONT></TD>
<TD WIDTH="21%" ALIGN="CENTER" VALIGN="CENTER"><FONT SIZE=2><BR>
January 24, 2002</FONT></TD>
</TR>
<TR VALIGN="TOP">
<TD WIDTH="45%" ALIGN="CENTER" VALIGN="CENTER"><FONT SIZE=2><BR>
/s/&nbsp;&nbsp;</FONT><FONT SIZE=2>ARI BISIMIS</FONT><FONT SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</FONT><HR NOSHADE><FONT SIZE=2> Ari Bisimis</FONT></TD>
<TD WIDTH="2%" VALIGN="CENTER"><FONT SIZE=2><BR>&nbsp;</FONT></TD>
<TD WIDTH="29%" VALIGN="CENTER"><FONT SIZE=2><BR>
Chief Financial Officer and Director</FONT></TD>
<TD WIDTH="2%" VALIGN="CENTER"><FONT SIZE=2><BR>&nbsp;</FONT></TD>
<TD WIDTH="21%" ALIGN="CENTER" VALIGN="CENTER"><FONT SIZE=2><BR>
January 24, 2002</FONT></TD>
</TR>
<TR VALIGN="BOTTOM">
<TD WIDTH="45%" ALIGN="CENTER" VALIGN="CENTER"><FONT SIZE=2><BR>
/s/&nbsp;&nbsp;</FONT><FONT SIZE=2>DAVID RICKEY</FONT><FONT SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</FONT><HR NOSHADE><FONT SIZE=2> David Rickey</FONT></TD>
<TD WIDTH="2%" VALIGN="CENTER"><FONT SIZE=2><BR>&nbsp;</FONT></TD>
<TD WIDTH="29%" VALIGN="CENTER"><FONT SIZE=2><BR>
Director</FONT></TD>
<TD WIDTH="2%" VALIGN="CENTER"><FONT SIZE=2><BR>&nbsp;</FONT></TD>
<TD WIDTH="21%" ALIGN="CENTER" VALIGN="CENTER"><FONT SIZE=2><BR>
January 24, 2002</FONT></TD>
</TR>
<TR VALIGN="BOTTOM">
<TD WIDTH="45%" ALIGN="CENTER" VALIGN="CENTER"><FONT SIZE=2><BR>
/s/&nbsp;&nbsp;</FONT><FONT SIZE=2>EDMUND KRIX</FONT><FONT SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</FONT><HR NOSHADE><FONT SIZE=2> Edmund Krix</FONT></TD>
<TD WIDTH="2%" VALIGN="CENTER"><FONT SIZE=2><BR>&nbsp;</FONT></TD>
<TD WIDTH="29%" VALIGN="CENTER"><FONT SIZE=2><BR>
Director</FONT></TD>
<TD WIDTH="2%" VALIGN="CENTER"><FONT SIZE=2><BR>&nbsp;</FONT></TD>
<TD WIDTH="21%" ALIGN="CENTER" VALIGN="CENTER"><FONT SIZE=2><BR>
January 24, 2002</FONT></TD>
</TR>
</TABLE>
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<P ALIGN="CENTER"><FONT SIZE=2>4</FONT></P>

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<BR></FONT><FONT SIZE=2><B>INDEX TO EXHIBITS    <BR>  </B></FONT></P>

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<TH WIDTH="9%" ALIGN="CENTER"><FONT SIZE=1><B>Exhibit<BR>
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<TH WIDTH="88%" ALIGN="CENTER"><FONT SIZE=1><B>Description</B></FONT><HR NOSHADE></TH>
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5.1</FONT></TD>
<TD WIDTH="3%"><FONT SIZE=2><BR>&nbsp;</FONT></TD>
<TD WIDTH="88%"><FONT SIZE=2><BR>
Opinion of Morgan, Lewis &amp; Bockius LLP.</FONT></TD>
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<TD WIDTH="9%" ALIGN="RIGHT"><FONT SIZE=2><BR>
23.1</FONT></TD>
<TD WIDTH="3%"><FONT SIZE=2><BR>&nbsp;</FONT></TD>
<TD WIDTH="88%"><FONT SIZE=2><BR>
Consent of Arthur Andersen LLP, Independent Public Accountants.</FONT></TD>
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23.2</FONT></TD>
<TD WIDTH="3%"><FONT SIZE=2><BR>&nbsp;</FONT></TD>
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Consent of PricewaterhouseCoopers LLP, Independent Accountants</FONT></TD>
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24.1</FONT></TD>
<TD WIDTH="3%"><FONT SIZE=2><BR>&nbsp;</FONT></TD>
<TD WIDTH="88%"><FONT SIZE=2><BR>
Power of Attorney (contained in the signature page).</FONT></TD>
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<P><br><A NAME="02SAN1094_1">QuickLinks</A><br></P><!-- TOC_BEGIN -->
<FONT SIZE=2><A HREF="#toc_da1094_1">PART II INFORMATION REQUIRED IN THE REGISTRATION STATEMENT</A></FONT><BR>
<UL>
<FONT SIZE=2><A HREF="#toc_da1094_2">Item 3. Incorporation of Documents by Reference.</A></FONT><BR>
<FONT SIZE=2><A HREF="#toc_da1094_3">Item 4. Description of Securities.</A></FONT><BR>
<FONT SIZE=2><A HREF="#toc_da1094_4">Item 5. Interests of Named Experts and Counsel.</A></FONT><BR>
<FONT SIZE=2><A HREF="#toc_da1094_5">Item 6. Indemnification of Directors and Officers.</A></FONT><BR>
<FONT SIZE=2><A HREF="#toc_da1094_6">Item 7. Exemption from Registration Claimed.</A></FONT><BR>
<FONT SIZE=2><A HREF="#toc_da1094_7">Item 8. Exhibits.</A></FONT><BR>
<FONT SIZE=2><A HREF="#toc_da1094_8">Item 9. Undertakings.</A></FONT><BR>
</UL>
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<FONT SIZE=2><A HREF="#toc_jc1094_1">SIGNATURES</A></FONT><BR>
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<FONT SIZE=2><A HREF="#toc_ka1094_1">INDEX TO EXHIBITS</A></FONT><BR>
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[{"type": "S-8", "sequence": "1", "filename": "a2069124zs-8.htm", "description": "S-8", "secsgml_size_bytes": 32410}]
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Prepared by MERRILL CORPORATION
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As filed with the Securities and Exchange Commission on February 1, 2002
Registration No. 333-
SECURITIES AND EXCHANGE COMMISSION
WASHINGTON, DC 20549
FORM S-8
REGISTRATION STATEMENT
UNDER
THE SECURITIES ACT OF 1933
MacroPore, Inc.
(Exact name of registrant as specified in its charter)
Delaware
330-827-593
(State or other jurisdiction of incorporation
or organization)
(I.R.S. Employer Identification No.)
6740 Top Gun Street
San Diego, CA
92121
(Address of principal executive offices)
(Zip Code)
MacroPore, Inc. Amended and Restated
1997 Stock Option and Stock Purchase Plan
(Full title of the plan)
Jon Soneff, Esq.
MacroPore, Inc.
6740 Top Gun Street
San Diego, CA 92121
(858) 458-0900
(Name, address and telephone number, including area code, of agent for service)
Copies of all communications to:
Peter P. Wallace, Esq.
Ingrid A. Myers, Esq.
Morgan, Lewis & Bockius LLP
300 South Grand Avenue, 22nd Floor
Los Angeles, CA 90071
(213) 612-2500
CALCULATION OF REGISTRATION FEE
Title of Securities
to be Registered
Amount to
be Registered(1)
Proposed Maximum
Offering Price
Per Share(2)
Proposed Maximum
Aggregate
Offering Price(2)
Amount of
Registration Fee
Common stock, par value $.01 per share
5,733,099 shares
$3.9971
$22,915,670
$2,108
(1)
This
registration statement includes shares of common stock of MacroPore, Inc. which are offered or sold pursuant to the plan named above. Pursuant to Rule 416(a) of the
Securities Act of 1933, this registration statement also includes any additional shares of common stock which are offered or issued under the plan to prevent dilution resulting from stock splits,
stock dividends or similar transactions.
(2)
With
respect to grants previously issued under the plan, the actual exercise price has been used to compute the maximum offering price pursuant to Rule 457(h)(1). For the
remaining shares issuable under the plan, the maximum offering price is estimated pursuant to paragraph (c) and (h) of Rule 457, solely for the purpose of calculating the
registration fee, based upon the average of the reported high and low sales prices for a share of common stock of MacroPore, Inc. on January 28, 2002 as reported on the
Neuer Markt
of the
Frankfurt Stock Exchange, which average was 3.90 Euros, or $3.3525 per share based on the exchange rate as of that date.
PART II
INFORMATION REQUIRED IN THE REGISTRATION STATEMENT
Item 3. Incorporation of Documents by Reference.
The
following documents filed by MacroPore, Inc. with the Commission are incorporated by reference into this registration statement. As used in this registration statement, the terms
"MacroPore," "we," "us," or "our" or similar terms refer to MacroPore, Inc.
1.
Our
registration statement on Form 10 filed pursuant to Section 12(g) of the Securities and Exchange Act of 1934 (the "Exchange Act") on March 30, 2001, as
amended, Commission File No. 000-32501;
2.
All
reports we have filed pursuant to Sections 13(a) or 15(d) of the Exchange Act since May 31, 2001 when our Form 10 referred to in (1) above became effective;
and
3.
The
description of our shares of common stock contained in the section entitled "Description of Capital Stock" in our Form 10 referenced in (1) above.
All
reports and other documents subsequently filed by us pursuant to Sections 13(a), 13(c), 14 and 15(d) of the Exchange Act after the date of this registration statement, but prior to the filing of a
post-effective amendment to this registration statement that indicates all of the securities offered by this registration statement have been sold or which deregisters all such securities
then remaining unsold, shall be deemed to be incorporated by reference into this registration statement. Each document incorporated by reference into this registration statement shall be deemed to be
a part of this registration statement from the date of the filing of such document with the Commission until the information contained therein is superseded or updated by any subsequently filed
document which is
incorporated by reference into this registration statement or by any document which constitutes part of the prospectus relating to our Amended and Restated 1997 Stock Option and Stock Purchase Plan
and meets the requirements of Section 10(a) of the Securities Act.
Any
statement contained herein or in a document all or a portion of which is incorporated by reference herein shall be deemed to be modified or superseded for purposes of this registration statement
to the extent that a statement contained in this registration statement or in any other subsequently filed document that is also incorporated by reference herein modifies or supersedes such statement.
Any such statement so modified or superseded shall not be deemed, except as so modified or superseded, to constitute a part of this registration statement.
Item 4. Description of Securities.
Not
Applicable.
Item 5. Interests of Named Experts and Counsel.
Not
Applicable.
Item 6. Indemnification of Directors and Officers.
Section 145 of the General Corporation Law of the State of Delaware permits us, under specified circumstances, to indemnify our directors, officers,
employees or agents against expenses, including attorney's fees, judgments, fines and amounts paid in settlements actually and reasonably incurred by them in connection with any action, suit or
proceeding brought by third parties by reason of the fact that they were or are our directors, officers, employees or agents or were or are serving at our request as a director, officer, employee or
agent of another corporation, if such directors, officers, employees, or agents acted in good faith and in a manner they reasonably believed to be in or not opposed to our
1
best interests of the corporation and, with respect to any criminal action or proceeding, had no reasonable cause to believe their conduct was unlawful. In a derivative action, one by or in our
right, indemnification may be made only for expenses actually and reasonably incurred by our directors,
officers, employees or agents in connection with the defense or settlement of an action or suit, and only with respect to a matter as to which they acted in good faith and in a manner they reasonably
believed to be in or not opposed to our best interests, except that no indemnification shall be made in respect of any claim, issue or matter as to which such person shall be adjudicated to be liable
to us unless the court in which the action or suit was brought determines upon application that the defendant directors, officers, employees, or agents are fairly and reasonably entitled to
indemnification for such expenses in view of all of the circumstances of the case, despite such adjudication of liability. We may pay expenses, including attorney's fees, incurred by an officer or
director in defending any civil, criminal, administrative or investigative action, suit or proceeding in advance of the final disposition of such action, suit or proceeding upon receipt of an
undertaking by or on behalf of such director or officer to repay such amount if a court ultimately determines that he is not entitled to be indemnified by us.
Article VI
of our by-laws require us to indemnify our current or former directors and officers and may indemnify other corporate agents, to the fullest extent
authorized or permitted by applicable law. Subject to applicable law and the provisions of our Amended and Restated Certificate of Incorporation regarding indemnification by us, we may indemnify an
employee or agent to the extent that the board of directors or our stockholders may determine in its or their discretion.
Article VII
of our Amended and Restated Certificate of Incorporation provides that our directors will not be personally liable to us or our stockholders for monetary damages
resulting from a breach of fiduciary duty as a director, except for (a) any breach of the director's duty of loyalty to us or our stockholders, (b) acts or omissions not in good faith or
which involve intentional misconduct or a knowing violation of law, (c) liability under Section 174 of the General Corporation Law of the State of Delaware, or (d) any transaction
from which a director derived an improper personal benefit. This limitation of liability does not apply to the responsibility or liability of our directors pursuant to any criminal statute, nor does
it relieve the directors from payment of taxes pursuant to federal, state or local law.
We
maintain an insurance policy containing customary terms and conditions for the purpose of insuring our directors and officers against certain losses incurred by them as a result of
claims based upon their actions or statements, including omissions to act or make statements, as directors and officers, which may cover liabilities under the Securities Act.
Item 7. Exemption from Registration Claimed.
Not
Applicable.
Item 8. Exhibits.
The
following exhibits are filed herewith or incorporated by reference as part of this registration statement:
Exhibit
No.
Description
5.1
Opinion of Morgan, Lewis & Bockius LLP.
23.1
Consent of Arthur Andersen LLP, Independent Public Accountants.
23.2
Consent of PricewaterhouseCoopers LLP, Independent Accountants
24.1
Power of Attorney (contained in the signature page).
2
Item 9. Undertakings.
The
undersigned registrant hereby undertakes:
(a)
(1) To file, during any period in which offers or sales are being made, a post-effective amendment to this registration statement:
(i)
To
include any prospectus required by Section 10(a)(3) of the Securities Act;
(ii)
To
reflect in the prospectus any facts or events arising after the effective date of this registration statement, or the most recent
post-effective amendment thereof, which, individually or in the aggregate, represent a fundamental change in the information set forth in this registration statement. Notwithstanding the
foregoing, any increase or decrease in volume of securities offered, if the total dollar value of securities offered would not exceed that which was registered, and any deviation from the low or high
end of the estimated maximum offering range may be reflected in the form of prospectus filed with the Commission pursuant to Rule 424(b) if, in the aggregate, the changes in volume and price
represent no more than 20 percent change in the maximum aggregate offering price set forth in the "Calculation of Registration Fee" table in the effective registration statement;
(iii)
To
include any material information with respect to the plan of distribution not previously disclosed in this registration statement or any material
change to such information in this registration statement.
(2)  That,
for the purpose of determining any liability under the Securities Act, each such post-effective amendment shall be deemed to be a new registration
statement relating to the securities offered therein, and the offering of such securities at that time shall be deemed to be the initial
bona fide
offering thereof.
(3)  To
remove from registration by means of a post-effective amendment any of the securities being registered which remain unsold at the termination of the
offering.
(b)
The undersigned registrant hereby undertakes that, for purposes of determining any liability under the Securities Act, each filing of the registrant's annual report pursuant to
Section 13(a) or Section 15(d) of the Exchange Act that is incorporated by reference in the registration statement shall be deemed to be a new registration statement relating to the
securities offered therein, and the offering of such securities at that time shall be deemed to be the initial
bona fide
offering thereof.
(c)
Insofar as indemnification for liabilities arising under the Securities Act may be permitted to directors, officers and controlling persons of the registrant pursuant to the foregoing provisions,
or otherwise, the registrant has been advised that in the opinion of the Commission such indemnification is against public policy as expressed in the Act and is, therefore, unenforceable. In the event
that a claim for indemnification against such liabilities (other than the payment by the registrant of expenses incurred or paid by a director, officer or controlling person of the registrant in the
successful defense of any action, suit or proceeding) is asserted by such director, officer or controlling person in connection with the securities being registered, the registrant will, unless in the
opinion of its counsel the matter has been settled by controlling precedent, submit to a court of appropriate jurisdiction the question whether such indemnification by it is against public policy as
expressed in the Act and will be governed by the final adjudication of such issue.
3
SIGNATURES
Pursuant to the requirements of the Securities Act of 1933, the registrant certifies that it has reasonable grounds to believe that it meets all of the
requirements for filing on Form S-8 and has duly caused this registration statement to be signed on its behalf by the undersigned, thereunto duly authorized, in the city of San
Diego, state of California, on this 24
th
day of January, 2002.
MACROPORE, INC.
By:
/s/
CHRISTOPHER J. CALHOUN
Christopher J. Calhoun
Chief Executive Officer, Vice-Chairman, Secretary
Pursuant
to the requirements of the Securities Act of 1933, this registration statement has been signed by the following persons in the capacities and on the date indicated. Each person
whose signature appears below hereby constitutes and appoints Christopher J. Calhoun, his true and lawful attorney-in-fact and agent, with full power of substitution and
re-substitution, for him and in his name, place and stead, in any and all capacities, to sign any and all amendments, including post-effective amendments, and supplements to
this registration statement, and to file the same with all the exhibits thereto, and other documents in connection therewith with the Securities and Exchange Commission, granting unto said
attorney-in-fact and agent, full power and authority to do and perform any and all acts and things requisite and necessary to be done, as fully as to all intents and purposes
as he might or could do in person, hereby ratifying and confirming all that said attorney-in-fact and agents of said attorney-in-fact, or his
substitute, may lawfully do or cause to be done by virtue hereof.
Signature
Title
Date
/s/
MARSHALL G. COX
Marshall G. Cox
Chairman of the Board and Director
January 24, 2002
/s/
CHRISTOPHER J. CALHOUN
Christopher J. Calhoun
Chief Executive Officer, Vice-Chairman, Secretary and Director
January 24, 2002
/s/
MICHAEL SIMPSON
Michael Simpson
President and Director
January 24, 2002
/s/
ARI BISIMIS
Ari Bisimis
Chief Financial Officer and Director
January 24, 2002
/s/
DAVID RICKEY
David Rickey
Director
January 24, 2002
/s/
EDMUND KRIX
Edmund Krix
Director
January 24, 2002
4
INDEX TO EXHIBITS
Exhibit
No.
Description
5.1
Opinion of Morgan, Lewis & Bockius LLP.
23.1
Consent of Arthur Andersen LLP, Independent Public Accountants.
23.2
Consent of PricewaterhouseCoopers LLP, Independent Accountants
24.1
Power of Attorney (contained in the signature page).
QuickLinks
PART II INFORMATION REQUIRED IN THE REGISTRATION STATEMENT
Item 3. Incorporation of Documents by Reference.
Item 4. Description of Securities.
Item 5. Interests of Named Experts and Counsel.
Item 6. Indemnification of Directors and Officers.
Item 7. Exemption from Registration Claimed.
Item 8. Exhibits.
Item 9. Undertakings.
SIGNATURES
INDEX TO EXHIBITS