<PAGE>
 
    As filed with the Securities and Exchange Commission on September 4, 1998


                                               REGISTRATION NO. 333-____________


                      SECURITIES AND EXCHANGE COMMISSION
                            Washington, D. C. 20549

                                   FORM S-8

                         REGISTRATION STATEMENT UNDER
                          THE SECURITIES ACT OF 1933

                            V.I. TECHNOLOGIES, INC.
            (Exact name of registrant as specified in its charter)


                 DELAWARE                         11-3238476
       (State or other jurisdiction            (I.R.S. Employer
             of incorporation)                Identification No.)


                   155 DURYEA ROAD, MELVILLE, NEW YORK 11747
             (Address of registrant's principal executive offices)

                          1998 EQUITY INCENTIVE PLAN
                           (Full Title of the Plan)


              JOHN R. BARR, PRESIDENT AND CHIEF EXECUTIVE OFFICER
                            V.I. Technologies, Inc.
                                155 Duryea Road
                           Melville, New York 11747
                                (516) 752-7314
           (Name, address and telephone number of agent for service)

                                with copies to:

                           STEVEN N. FARBER, ESQUIRE
                          MARC A. RUBENSTEIN, ESQUIRE
                              Palmer & Dodge LLP
                               One Beacon Street
                          Boston, Massachusetts 02108
                                (617) 573-0100


                        CALCULATION OF REGISTRATION FEE
<TABLE>
<CAPTION>
------------------------------------------------------------------------------------------------------------------------------------

Title of each class         
of securities to                     Amount to be       Proposed maximum offering     Proposed maximum aggregate      Amount of
 be registered                        registered              price per share                offering price        registration fee
------------------------------------------------------------------------------------------------------------------------------------

<S>                                <C>                  <C>                           <C>                          <C>
Common Stock, $0.01 par value      2,146,690 shares             $11.75(1)                     $25,223,608(1)           $7,440.96
------------------------------------------------------------------------------------------------------------------------------------
</TABLE>
(1)  Estimated solely for the purpose of determining the registration fee and
     computed pursuant to Rule 457(h) based upon the average of the high and low
     sale prices on August 28, 1998 as reported by the Nasdaq National Market.
<PAGE>
 
                                    PART II
              INFORMATION REQUIRED IN THE REGISTRATION STATEMENT


Item 3.  Incorporation of Documents by Reference.
------------------------------------------------ 

         The following documents filed with the Securities and Exchange
Commission (the "Commission") are incorporated herein by reference:

(a)      The Registrant's Final Prospectus filed with the Commission on June 11,
         1998 pursuant to Rule 424(b)(4) under the Securities Act of 1933, as
         amended.

(b)      All other reports of the Registrant filed pursuant to Section 13(a) or
         15(d) of the Securities Exchange Act of 1934, as amended (the "Exchange
         Act"), since the end of the last fiscal year covered by the Final
         Prospectus referred to in (a) above.

(c)      The description of the Registrant's Common Stock contained in its
         Registration Statement on Form 8-A filed with the Commission on May 13,
         1998, including any amendment or report filed hereafter for the purpose
         of updating such description.

         All documents filed after the date of this Registration Statement by
the Registrant pursuant to Section 13(a), 13(c), 14 and 15(d) of the Exchange
Act and prior to the filing of a post-effective amendment that indicates that
all shares of Common Stock offered hereunder have been sold or which deregisters
all shares of Common Stock remaining unsold shall be deemed to be incorporated
by reference herein and to be a part hereof from the date of the filing of such
reports and documents.

Item 4.  Description of Securities.
-----------------------------------

         Not applicable.

Item 5.  Interests of Named Experts and Counsel.
------------------------------------------------

         The validity of the Common Stock offered hereby will be passed upon for
the Registrant by Palmer & Dodge LLP, Boston, Massachusetts.

Item 6. Indemnification of Directors and Officers.
--------------------------------------------------

        Article NINTH of the Registrant's Restated Certificate of Incorporation
provides that directors of the Registrant will not be personally liable to the
Registrant or its stockholders for monetary damages for breach of fiduciary duty
as a director, whether or not an individual continues to be a director at the
time such liability is asserted, except for liability (i) for any breach of the
director's duty of loyalty to the Registrant or its stockholders, (ii) for acts
or omissions not in good faith or which involve intentional misconduct or a
knowing violation of law, (iii) pursuant to Section 174 of the Delaware General
Corporation Law or (iv) for any transaction from which the director derives an
improper personal benefit.

        Article TENTH of the Registrant's Restated Certificate of Incorporation
provides that the Registrant shall, to the fullest extent permitted by the
General Corporation Law of the State of Delaware, as amended from time to time,
indemnify each person who was or is a party or is threatened to be made a party
to any threatened, pending or completed action, suit or proceeding, by reason of
the fact that he is or was, or has agreed to become a director or officer of the
Registrant, or is or was serving, or has agreed to serve, at the request of the
Registrant as a director, officer or trustee of, or in a similar capacity with,
another corporation, partnership, joint venture, trust or other enterprise.  The
indemnification provided for in Article TENTH is expressly not exclusive of any
other rights to which those seeking indemnification may be entitled under any
law, agreement or vote of stockholders or disinterested directors or otherwise,
and shall inure to the benefit of the heirs, executors and administrators of
such persons.  Article TENTH 
<PAGE>
 
further permits the Board of Directors to authorize the grant of indemnification
rights to other employees and agents of the Registrant and such rights may be
equivalent to, or greater or less than, those set forth in Article TENTH.

        Section 145 of the Delaware General Corporation Law grants the
Registrant the power to indemnify each person who was or is a party or is
threatened to be made a party to any threatened, pending or completed action,
suit or proceeding, whether civil, criminal, administrative or investigative by
reason of the fact that he is or was a director, officer, employee or agent of
the Registrant, or is or was serving at the request of the Registrant as a
director, officer, employee or agent of another corporation, partnership, joint
venture, trust or other enterprise, against expenses (including attorneys' fees)
judgments, fines and amounts paid in settlement actually and reasonably incurred
by him in connection with any action, suit or proceeding if (i) he acted in good
faith and in a manner he reasonably believed to be in or not opposed to the best
interests of the Registrant and (ii) with respect to any criminal action or
proceeding, he had no reasonable cause to believe his conduct was unlawful,
provided, however, no indemnification shall be made in connection with any
proceeding brought by or in the right of the Registrant where the person
involved is adjudged to be liable to the Registrant except to the extent
approved by a court.

        Pursuant to Section 145 of the General Corporation Law of the State of
Delaware and the By-laws of the Registrant, the Registrant maintains insurance
for directors and executive officers and has entered into agreements with all of
its executive officers and directors affirming the Registrant's obligation to
indemnify them to the fullest extent permitted by law and providing various
other protections.

Item 7. Exemption from Registration Claimed.
--------------------------------------------

        Not applicable.

Item 8. Exhibits.
-----------------
<TABLE>
<CAPTION>

    Exhibit Number                                    Description
    --------------                                    -----------
<C>                      <S>
        4.1              Restated Certificate of Incorporation of the Registrant.  Incorporated by
                         reference to the Registrant's Registration Statement on Form S-1, filed with
                         the Commission on February 26, 1998 (File No. 333-46933).

        4.2              Amended and Restated By-laws of the Registrant.  Incorporated by reference
                         to the Registrant's Registration Statement on Form S-1, filed with the
                         Commission on February 26, 1998 (File No. 333-46933).

        4.3              Form of Certificate for Common Stock.  Incorporated by reference to the
                         Registrant's Registration Statement on Form S-1, filed with the Commission
                         on February 26, 1998 (File No. 333-46933).

        5.1              Opinion of Palmer & Dodge LLP as to the legality of the securities
                         registered hereunder.  Filed herewith.

       23.1              Consent of KPMG Peat Marwick LLP, independent auditors.  Filed herewith.

       23.2              Consent of Palmer & Dodge LLP.  Contained in Opinion of Palmer & Dodge LLP,
                         filed as Exhibit 5.1 hereto.

       24.1              Power of Attorney.  Set forth on the signature page to this Registration
                         Statement.
</TABLE>
<PAGE>
 
Item 9.  Undertakings.
--------------------- 

         (a)    The undersigned Registrant hereby undertakes:

                (1)   To file, during any period in which offers or sales are
being made, a post-effective amendment to this registration statement:

                      (i)   To include any prospectus required by Section
10(a)(3) of the Securities Act of 1933;

                      (ii)  To reflect in the prospectus any facts or events
arising after the effective date of this Registration Statement (or the most
recent post-effective amendment thereof) which, individually or in the
aggregate, represents a fundamental change in the information set forth in this
Registration Statement;

                      (iii) To include any material information with respect to
the plan of distribution not previously disclosed in this Registration Statement
or any material change to such information in this Registration Statement;

provided, however, that paragraphs (a)(1)(i) and (a)(1)(ii) do not apply if the
--------  -------                                                              
information required to be included in a post-effective amendment by those
paragraphs is contained in periodic reports filed with or furnished to the
Commission by the Registrant pursuant to Section 13 or Section 15(d) of the
Exchange Act that are incorporated by reference in this Registration Statement.

                (2)   That, for the purpose of determining any liability under
the Securities Act of 1933, each such post-effective amendment shall be deemed
to be a new registration statement relating to the securities offered therein,
and the offering of such securities at that time shall be deemed to be the
initial bona fide offering thereof.

                (3)   To remove from registration by means of a post-effective
amendment any of the securities being registered which remain unsold at the
termination of the offering.

         (b)    The undersigned Registrant hereby undertakes that, for purposes
of determining any liability under the Securities Act of 1933, each filing of
the Registrant's annual report pursuant to Section 13(a) or Section 15(d) of the
Exchange that is incorporated by reference in this Registration Statement shall
be deemed to be a new registration statement relating to the securities offered
therein, and the offering of such securities at that time shall be deemed to be
the initial bona fide offering thereof.

         (c) Insofar as indemnification for liabilities arising under the
Securities Act of 1933 may be permitted to directors, officers and controlling
persons of the Registrant pursuant to the provisions referred to in Item 6
hereof, or otherwise, the Registrant has been advised that in the opinion of the
Commission such indemnification is against public policy as expressed in the Act
and is, therefore, unenforceable. In the event that a claim for indemnification
against such liabilities (other than the payment by the Registrant of expenses
incurred or paid by a director, officer or controlling person of the registrant
in the successful defense of any action, suit or proceeding) is asserted by such
director, officer or controlling person in connection with the securities being
registered, the Registrant will, unless in the opinion of its counsel the matter
has been settled by controlling precedent, submit to a court of appropriate
jurisdiction the question whether such indemnification by it is against public
policy as expressed in the Act and will be governed by the final adjudication of
such issue.
<PAGE>
 
                                 SIGNATURES

        Pursuant to the requirements of the Securities Act of 1933, the
Registrant certifies that it has reasonable grounds to believe that it meets all
of the requirements for filing on Form S-8 and has duly caused this Registration
Statement to be signed on its behalf by the undersigned, thereunto duly
authorized, in the City of Melville, State of New York, on this 4th day of
September, 1998.

                                    V.I. TECHNOLOGIES, INC.


                                    By: /s/ John R. Barr
                                    -----------------------------------------
                                        John R. Barr
                                        President and Chief Executive Officer
<PAGE>
 
                               POWER OF ATTORNEY


        We, the undersigned officers and directors of V.I. Technologies, Inc.
hereby severally constitute and appoint John R. Barr, Thomas T. Higgins and Marc
A. Rubenstein and each of them singly, our true and lawful attorneys-in-fact,
with full power to them in any and all capacities, to sign any and all
amendments to this Registration Statement on Form S-8, including any post-
effective amendments thereto, and to file the same, with exhibits thereto and
other documents in connection therewith, with the Securities and Exchange
Commission, hereby ratifying and confirming all that each of said attorneys-in-
fact may do or cause to be done by virtue hereof.

        Pursuant to the requirements of the Securities Act of 1933, this
Registration Statement has been signed below by the following persons in the
capacities and on the dates indicated:

<TABLE> 
<CAPTION> 

    Signature                     TITLE                                  DATE 
    ---------                     -----                                  ----  
<S>                             <C>                                    <C> 
                                                                    
/s/ John R. Barr                President, Chief Executive             September 4, 1998
------------------------        Officer and Director                
John R. Barr                    (Principal Executive Officer)       
                                                                    
/s/ Thomas T. Higgins           Executive Vice President and           September 4, 1998
------------------------        Chief Financial Officer
Thomas T. Higgins               (Principal Financial Officer and    
                                Principal Accounting Officer)       
                                                                    
/s/ David Tendler               Director                               September 4, 1998
------------------------
David Tendler                                                       
                                                                    
/s/ Richard A. Charpie          Director                               September 4, 1998
------------------------
Richard A. Charpie                                                  
                                                                    
/s/ Jeremy Hayward-Surry        Director                               September 4, 1998
------------------------
Jeremy Hayward-Surry                                                
                                                                    
/s/ Bernard Horowitz            Director                               September 4, 1998
------------------------
Bernard Horowitz                                                    
                                                                    
/s/ Irwin Lerner                Director                               September 4, 1998
------------------------
Irwin Lerner

</TABLE> 
<PAGE>
 
<TABLE> 

<S>                             <C>                                    <C> 
/s/ Peter D. Parker             Director                               September 4, 1998
------------------------
Peter D. Parker


/s/ Damion E. Wicker            Director                               September 4, 1998
------------------------
Damion E. Wicker, M.D.

</TABLE> 
<PAGE>
 
                                 EXHIBIT INDEX
                                 -------------


<TABLE>
<CAPTION>

Exhibit Number                         Description
--------------                         -----------
<C>                  <S>

     4.1             Restated Certificate of Incorporation of the Registrant.
                     Incorporated by reference to the Registrant's
                     Registration Statement on Form S-1, filed with the
                     Commission on February 26, 1998 (File No. 333-46933).

     4.2             Amended and Restated By-laws of the Registrant.
                     Incorporated by reference to the Registrant's
                     Registration Statement on Form S-1, filed with the
                     Commission on February 26, 1998 (File No. 333-46933).

     4.3             Form of Certificate for Common Stock.  Incorporated by
                     reference to the Registrant's Registration Statement on
                     Form S-1, filed with the Commission on February 26, 1998
                     (File No. 333-46933).

     5.1             Opinion of Palmer & Dodge LLP as to the legality of the
                     securities registered hereunder.  Filed herewith.

    23.1             Consent of KPMG Peat Marwick LLP, independent auditors.
                     Filed herewith.

    23.2             Consent of Palmer & Dodge LLP.  Contained in Opinion of
                     Palmer & Dodge LLP, filed as Exhibit 5.1 hereto.

    24.1             Power of Attorney.  Set forth on the signature page to
                     this Registration Statement.

</TABLE>
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{"company-data": {"conformed-name": "V I TECHNOLOGIES INC", "cik": "0001040017", "assigned-sic": "2836", "irs-number": "113238476", "state-of-incorporation": "DE", "fiscal-year-end": "1231"}, "filing-values": {"form-type": "S-8", "act": "33", "file-number": "333-62927", "film-number": "98704675"}, "business-address": {"street1": "155 DURYEA RD", "city": "MELVILLE", "state": "NY", "zip": "11747", "phone": "5167527314"}, "mail-address": {"street1": "155 DURYEA RD", "city": "MELVILLE", "state": "NY", "zip": "11747"}}
As filed with the Securities and Exchange Commission on September 4, 1998

                                               REGISTRATION NO. 333-____________

                      SECURITIES AND EXCHANGE COMMISSION
                            Washington, D. C. 20549

                                   FORM S-8

                         REGISTRATION STATEMENT UNDER
                          THE SECURITIES ACT OF 1933

                            V.I. TECHNOLOGIES, INC.
            (Exact name of registrant as specified in its charter)

                 DELAWARE                         11-3238476
       (State or other jurisdiction            (I.R.S. Employer
             of incorporation)                Identification No.)

                   155 DURYEA ROAD, MELVILLE, NEW YORK 11747
             (Address of registrant's principal executive offices)

                          1998 EQUITY INCENTIVE PLAN
                           (Full Title of the Plan)

              JOHN R. BARR, PRESIDENT AND CHIEF EXECUTIVE OFFICER
                            V.I. Technologies, Inc.
                                155 Duryea Road
                           Melville, New York 11747
                                (516) 752-7314
           (Name, address and telephone number of agent for service)

                                with copies to:

                           STEVEN N. FARBER, ESQUIRE
                          MARC A. RUBENSTEIN, ESQUIRE
                              Palmer & Dodge LLP
                               One Beacon Street
                          Boston, Massachusetts 02108
                                (617) 573-0100

                        CALCULATION OF REGISTRATION FEE
------------------------------------------------------------------------------------------------------------------------------------

Title of each class         
of securities to                     Amount to be       Proposed maximum offering     Proposed maximum aggregate      Amount of
 be registered                        registered              price per share                offering price        registration fee
------------------------------------------------------------------------------------------------------------------------------------
Common Stock, $0.01 par value      2,146,690 shares             $11.75(1)                     $25,223,608(1)           $7,440.96
------------------------------------------------------------------------------------------------------------------------------------
(1)  Estimated solely for the purpose of determining the registration fee and
     computed pursuant to Rule 457(h) based upon the average of the high and low
     sale prices on August 28, 1998 as reported by the Nasdaq National Market.
PART II
              INFORMATION REQUIRED IN THE REGISTRATION STATEMENT

Item 3.  Incorporation of Documents by Reference.
------------------------------------------------ 

         The following documents filed with the Securities and Exchange
Commission (the "Commission") are incorporated herein by reference:

(a)      The Registrant's Final Prospectus filed with the Commission on June 11,
         1998 pursuant to Rule 424(b)(4) under the Securities Act of 1933, as
         amended.

(b)      All other reports of the Registrant filed pursuant to Section 13(a) or
         15(d) of the Securities Exchange Act of 1934, as amended (the "Exchange
         Act"), since the end of the last fiscal year covered by the Final
         Prospectus referred to in (a) above.

(c)      The description of the Registrant's Common Stock contained in its
         Registration Statement on Form 8-A filed with the Commission on May 13,
         1998, including any amendment or report filed hereafter for the purpose
         of updating such description.

         All documents filed after the date of this Registration Statement by
the Registrant pursuant to Section 13(a), 13(c), 14 and 15(d) of the Exchange
Act and prior to the filing of a post-effective amendment that indicates that
all shares of Common Stock offered hereunder have been sold or which deregisters
all shares of Common Stock remaining unsold shall be deemed to be incorporated
by reference herein and to be a part hereof from the date of the filing of such
reports and documents.

Item 4.  Description of Securities.
-----------------------------------

         Not applicable.

Item 5.  Interests of Named Experts and Counsel.
------------------------------------------------

         The validity of the Common Stock offered hereby will be passed upon for
the Registrant by Palmer & Dodge LLP, Boston, Massachusetts.

Item 6. Indemnification of Directors and Officers.
--------------------------------------------------

        Article NINTH of the Registrant's Restated Certificate of Incorporation
provides that directors of the Registrant will not be personally liable to the
Registrant or its stockholders for monetary damages for breach of fiduciary duty
as a director, whether or not an individual continues to be a director at the
time such liability is asserted, except for liability (i) for any breach of the
director's duty of loyalty to the Registrant or its stockholders, (ii) for acts
or omissions not in good faith or which involve intentional misconduct or a
knowing violation of law, (iii) pursuant to Section 174 of the Delaware General
Corporation Law or (iv) for any transaction from which the director derives an
improper personal benefit.

        Article TENTH of the Registrant's Restated Certificate of Incorporation
provides that the Registrant shall, to the fullest extent permitted by the
General Corporation Law of the State of Delaware, as amended from time to time,
indemnify each person who was or is a party or is threatened to be made a party
to any threatened, pending or completed action, suit or proceeding, by reason of
the fact that he is or was, or has agreed to become a director or officer of the
Registrant, or is or was serving, or has agreed to serve, at the request of the
Registrant as a director, officer or trustee of, or in a similar capacity with,
another corporation, partnership, joint venture, trust or other enterprise.  The
indemnification provided for in Article TENTH is expressly not exclusive of any
other rights to which those seeking indemnification may be entitled under any
law, agreement or vote of stockholders or disinterested directors or otherwise,
and shall inure to the benefit of the heirs, executors and administrators of
such persons.  Article TENTH
further permits the Board of Directors to authorize the grant of indemnification
rights to other employees and agents of the Registrant and such rights may be
equivalent to, or greater or less than, those set forth in Article TENTH.

        Section 145 of the Delaware General Corporation Law grants the
Registrant the power to indemnify each person who was or is a party or is
threatened to be made a party to any threatened, pending or completed action,
suit or proceeding, whether civil, criminal, administrative or investigative by
reason of the fact that he is or was a director, officer, employee or agent of
the Registrant, or is or was serving at the request of the Registrant as a
director, officer, employee or agent of another corporation, partnership, joint
venture, trust or other enterprise, against expenses (including attorneys' fees)
judgments, fines and amounts paid in settlement actually and reasonably incurred
by him in connection with any action, suit or proceeding if (i) he acted in good
faith and in a manner he reasonably believed to be in or not opposed to the best
interests of the Registrant and (ii) with respect to any criminal action or
proceeding, he had no reasonable cause to believe his conduct was unlawful,
provided, however, no indemnification shall be made in connection with any
proceeding brought by or in the right of the Registrant where the person
involved is adjudged to be liable to the Registrant except to the extent
approved by a court.

        Pursuant to Section 145 of the General Corporation Law of the State of
Delaware and the By-laws of the Registrant, the Registrant maintains insurance
for directors and executive officers and has entered into agreements with all of
its executive officers and directors affirming the Registrant's obligation to
indemnify them to the fullest extent permitted by law and providing various
other protections.

Item 7. Exemption from Registration Claimed.
--------------------------------------------

        Not applicable.

Item 8. Exhibits.
-----------------
Exhibit Number                                    Description
    --------------                                    -----------
4.1              Restated Certificate of Incorporation of the Registrant.  Incorporated by
                         reference to the Registrant's Registration Statement on Form S-1, filed with
                         the Commission on February 26, 1998 (File No. 333-46933).

        4.2              Amended and Restated By-laws of the Registrant.  Incorporated by reference
                         to the Registrant's Registration Statement on Form S-1, filed with the
                         Commission on February 26, 1998 (File No. 333-46933).

        4.3              Form of Certificate for Common Stock.  Incorporated by reference to the
                         Registrant's Registration Statement on Form S-1, filed with the Commission
                         on February 26, 1998 (File No. 333-46933).

        5.1              Opinion of Palmer & Dodge LLP as to the legality of the securities
                         registered hereunder.  Filed herewith.

       23.1              Consent of KPMG Peat Marwick LLP, independent auditors.  Filed herewith.

       23.2              Consent of Palmer & Dodge LLP.  Contained in Opinion of Palmer & Dodge LLP,
                         filed as Exhibit 5.1 hereto.

       24.1              Power of Attorney.  Set forth on the signature page to this Registration
                         Statement.
Item 9.  Undertakings.
--------------------- 

         (a)    The undersigned Registrant hereby undertakes:

                (1)   To file, during any period in which offers or sales are
being made, a post-effective amendment to this registration statement:

                      (i)   To include any prospectus required by Section
10(a)(3) of the Securities Act of 1933;

                      (ii)  To reflect in the prospectus any facts or events
arising after the effective date of this Registration Statement (or the most
recent post-effective amendment thereof) which, individually or in the
aggregate, represents a fundamental change in the information set forth in this
Registration Statement;

                      (iii) To include any material information with respect to
the plan of distribution not previously disclosed in this Registration Statement
or any material change to such information in this Registration Statement;

provided, however, that paragraphs (a)(1)(i) and (a)(1)(ii) do not apply if the
--------  -------                                                              
information required to be included in a post-effective amendment by those
paragraphs is contained in periodic reports filed with or furnished to the
Commission by the Registrant pursuant to Section 13 or Section 15(d) of the
Exchange Act that are incorporated by reference in this Registration Statement.

                (2)   That, for the purpose of determining any liability under
the Securities Act of 1933, each such post-effective amendment shall be deemed
to be a new registration statement relating to the securities offered therein,
and the offering of such securities at that time shall be deemed to be the
initial bona fide offering thereof.

                (3)   To remove from registration by means of a post-effective
amendment any of the securities being registered which remain unsold at the
termination of the offering.

         (b)    The undersigned Registrant hereby undertakes that, for purposes
of determining any liability under the Securities Act of 1933, each filing of
the Registrant's annual report pursuant to Section 13(a) or Section 15(d) of the
Exchange that is incorporated by reference in this Registration Statement shall
be deemed to be a new registration statement relating to the securities offered
therein, and the offering of such securities at that time shall be deemed to be
the initial bona fide offering thereof.

         (c) Insofar as indemnification for liabilities arising under the
Securities Act of 1933 may be permitted to directors, officers and controlling
persons of the Registrant pursuant to the provisions referred to in Item 6
hereof, or otherwise, the Registrant has been advised that in the opinion of the
Commission such indemnification is against public policy as expressed in the Act
and is, therefore, unenforceable. In the event that a claim for indemnification
against such liabilities (other than the payment by the Registrant of expenses
incurred or paid by a director, officer or controlling person of the registrant
in the successful defense of any action, suit or proceeding) is asserted by such
director, officer or controlling person in connection with the securities being
registered, the Registrant will, unless in the opinion of its counsel the matter
has been settled by controlling precedent, submit to a court of appropriate
jurisdiction the question whether such indemnification by it is against public
policy as expressed in the Act and will be governed by the final adjudication of
such issue.
SIGNATURES

        Pursuant to the requirements of the Securities Act of 1933, the
Registrant certifies that it has reasonable grounds to believe that it meets all
of the requirements for filing on Form S-8 and has duly caused this Registration
Statement to be signed on its behalf by the undersigned, thereunto duly
authorized, in the City of Melville, State of New York, on this 4th day of
September, 1998.

                                    V.I. TECHNOLOGIES, INC.

                                    By: /s/ John R. Barr
                                    -----------------------------------------
                                        John R. Barr
                                        President and Chief Executive Officer
POWER OF ATTORNEY

        We, the undersigned officers and directors of V.I. Technologies, Inc.
hereby severally constitute and appoint John R. Barr, Thomas T. Higgins and Marc
A. Rubenstein and each of them singly, our true and lawful attorneys-in-fact,
with full power to them in any and all capacities, to sign any and all
amendments to this Registration Statement on Form S-8, including any post-
effective amendments thereto, and to file the same, with exhibits thereto and
other documents in connection therewith, with the Securities and Exchange
Commission, hereby ratifying and confirming all that each of said attorneys-in-
fact may do or cause to be done by virtue hereof.

        Pursuant to the requirements of the Securities Act of 1933, this
Registration Statement has been signed below by the following persons in the
capacities and on the dates indicated:
Signature                     TITLE                                  DATE 
    ---------                     -----                                  ----
/s/ John R. Barr                President, Chief Executive             September 4, 1998
------------------------        Officer and Director                
John R. Barr                    (Principal Executive Officer)       
                                                                    
/s/ Thomas T. Higgins           Executive Vice President and           September 4, 1998
------------------------        Chief Financial Officer
Thomas T. Higgins               (Principal Financial Officer and    
                                Principal Accounting Officer)       
                                                                    
/s/ David Tendler               Director                               September 4, 1998
------------------------
David Tendler                                                       
                                                                    
/s/ Richard A. Charpie          Director                               September 4, 1998
------------------------
Richard A. Charpie                                                  
                                                                    
/s/ Jeremy Hayward-Surry        Director                               September 4, 1998
------------------------
Jeremy Hayward-Surry                                                
                                                                    
/s/ Bernard Horowitz            Director                               September 4, 1998
------------------------
Bernard Horowitz                                                    
                                                                    
/s/ Irwin Lerner                Director                               September 4, 1998
------------------------
Irwin Lerner
/s/ Peter D. Parker             Director                               September 4, 1998
------------------------
Peter D. Parker

/s/ Damion E. Wicker            Director                               September 4, 1998
------------------------
Damion E. Wicker, M.D.
EXHIBIT INDEX
                                 -------------
Exhibit Number                         Description
--------------                         -----------
4.1             Restated Certificate of Incorporation of the Registrant.
                     Incorporated by reference to the Registrant's
                     Registration Statement on Form S-1, filed with the
                     Commission on February 26, 1998 (File No. 333-46933).

     4.2             Amended and Restated By-laws of the Registrant.
                     Incorporated by reference to the Registrant's
                     Registration Statement on Form S-1, filed with the
                     Commission on February 26, 1998 (File No. 333-46933).

     4.3             Form of Certificate for Common Stock.  Incorporated by
                     reference to the Registrant's Registration Statement on
                     Form S-1, filed with the Commission on February 26, 1998
                     (File No. 333-46933).

     5.1             Opinion of Palmer & Dodge LLP as to the legality of the
                     securities registered hereunder.  Filed herewith.

    23.1             Consent of KPMG Peat Marwick LLP, independent auditors.
                     Filed herewith.

    23.2             Consent of Palmer & Dodge LLP.  Contained in Opinion of
                     Palmer & Dodge LLP, filed as Exhibit 5.1 hereto.

    24.1             Power of Attorney.  Set forth on the signature page to
                     this Registration Statement.