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    <div style="text-align: center; font-family: 'Times New Roman', Times, serif; font-size: 10pt; font-weight: bold;">As filed with the Securities and Exchange Commission on December 13, 2018.</div>
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    <div style="text-align: right;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif; font-weight: bold;">Registration No. 333-</font></div>
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      <hr align="center" style="border: none; border-bottom: 1px solid black; border-top: 4px solid black; height: 10px; color: #ffffff; background-color: #ffffff; text-align: center; margin-left: auto; margin-right: auto;"><font style="font-size: 10pt;
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    <div style="text-align: center;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif; font-weight: bold;">UNITED STATES</font></div>
    <div style="text-align: center;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif; font-weight: bold;">SECURITIES AND EXCHANGE COMMISSION</font></div>
    <div style="text-align: center;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif; font-weight: bold;">WASHINGTON, D.C. 20549</font></div>
    <div style="text-align: center;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">____________</font></div>
    <div style="text-align: center;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;"> <br>
      </font></div>
    <div style="text-align: center;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif; font-weight: bold;">FORM S-8</font></div>
    <div style="text-align: center;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif; font-weight: bold;">REGISTRATION STATEMENT UNDER THE</font></div>
    <div style="text-align: center;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif; font-weight: bold;">SECURITIES ACT OF&#160;1933</font></div>
    <div style="text-align: center;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">____________</font></div>
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    </div>
    <div style="text-align: center;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif; font-weight: bold;">APTOSE BIOSCIENCES INC.</font></div>
    <div style="text-align: center;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif; font-weight: bold;">(Exact name of registrant as specified in its charter)</font></div>
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            <div style="text-align: center;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif; font-weight: bold;">Canada</font></div>
            <div style="text-align: center;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif; font-weight: bold;">(State or Other Jurisdiction of</font></div>
            <div style="text-align: center;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif; font-weight: bold;">Incorporation or Organization)</font></div>
          </td>
          <td style="width: 28.2%; vertical-align: top;">&#160;</td>
          <td style="width: 34.96%; vertical-align: top;">
            <div style="text-align: center;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif; font-weight: bold;">98-1136802</font></div>
            <div style="text-align: center;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif; font-weight: bold;">(I.R.S. Employer</font></div>
            <div style="text-align: center;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif; font-weight: bold;">Identification No.)</font></div>
          </td>
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          <td style="width: 36.84%; vertical-align: top;">&#160;</td>
          <td style="width: 28.2%; vertical-align: top;">
            <div style="text-align: center;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif; font-weight: bold;">____________</font></div>
            <div>&#160;</div>
          </td>
          <td style="width: 34.96%; vertical-align: top;">&#160;</td>
        </tr>
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          <td style="width: 36.84%; vertical-align: top;">&#160;</td>
          <td style="width: 28.2%; vertical-align: top;">
            <div style="text-align: center;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif; font-weight: bold;">251 Consumers Road, Suite 1105, Toronto, Ontario, Canada M2J 4R3 <font style="font-size: 10pt; font-family: 'Times
                  New Roman', Times, serif;">(Address of Principal Executive Offices)</font></font></div>
            <div style="text-align: center;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif; font-weight: bold;">____________</font></div>
            <div>&#160;</div>
          </td>
          <td style="width: 34.96%; vertical-align: top;">&#160;</td>
        </tr>
        <tr>
          <td colspan="3" style="width: 100%; vertical-align: top;">
            <div style="text-align: center;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif; font-weight: bold;">Aptose Biosciences Inc. Share Option Plan (&#8220;Option Plan&#8221;)</font></div>
            <div style="text-align: center;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif; font-weight: bold;">Aptose Biosciences Inc. 2015 Stock Incentive Plan (&#8220;RSU Plan&#8221;)</font></div>
            <div style="text-align: center;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif; font-weight: bold;">(Full title of the plan)</font></div>
            <div style="text-align: center;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif; font-weight: bold;">____________</font></div>
            <div>&#160;</div>
          </td>
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          <td colspan="3" style="width: 100%; vertical-align: top;">
            <div style="text-align: center;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif; font-weight: bold;">Aptose Biosciences U.S. Inc.<font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;"><br>
                </font>12270 High Bluff Drive, Suite 120<font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;"><br>
                </font>San Diego, California 92130</font></div>
            <div style="text-align: center;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif; font-weight: bold;">&#160;(Name, address and telephone number, including area code, of agent for service)</font></div>
            <div style="text-align: center;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif; font-weight: bold;">____________</font></div>
            <div style="text-align: center;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif; font-weight: bold;"> <br>
              </font></div>
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            <div style="margin: 0px 0px 5px; text-align: justify;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, a
                non-accelerated filer, or a smaller reporting company. See the definitions of &#8220;large accelerated filer,&#8221; &#8220;accelerated filer&#8221; and &#8220;smaller reporting company&#8221; in Rule 12b-2 of the Exchange Act. (Check one):</font></div>
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    <div style="text-align: center;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;"> </font>
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            <td style="width: 70%;">Large accelerated filer &#9744;</td>
            <td style="width: 30%;">Accelerated filer &#9744;</td>
          </tr>
          <tr>
            <td style="width: 70%;">Non-accelerated filer &#9744; (Do not check if a smaller reporting company)<br>
            </td>
            <td style="width: 30%;">Smaller reporting company &#9746;</td>
          </tr>

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    </div>
    <div style="text-align: center;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">____________</font></div>
    <div style="text-align: center;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;"> <br>
      </font></div>
    <div style="text-align: center; margin-bottom: 6pt;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif; font-weight: bold;">CALCULATION OF REGISTRATION FEE</font></div>
    <table cellspacing="0" cellpadding="0" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%;" id="z7c4f87a269894e99b8d79db1bb78f404">

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            <div style="text-align: center;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif; font-weight: bold;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;"><br>
                </font>Title of Securities </font></div>
            <div style="text-align: center;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif; font-weight: bold;">To Be Registered</font></div>
          </td>
          <td style="width: 13.88%; vertical-align: bottom; border-bottom: 2px solid rgb(0, 0, 0); border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);">
            <div style="text-align: center;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif; font-weight: bold;">Amount To Be<font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;"><br>
                </font>Registered (1)</font></div>
          </td>
          <td style="width: 19.29%; vertical-align: bottom; border-bottom: 2px solid rgb(0, 0, 0); border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);">
            <div style="text-align: center;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif; font-weight: bold;">Proposed Maximum Offering Price<font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;"><br>
                </font>Per Share (2)</font></div>
          </td>
          <td style="width: 19.81%; vertical-align: bottom; border-bottom: 2px solid rgb(0, 0, 0); border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);">
            <div style="text-align: center;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif; font-weight: bold;">Proposed Maximum Aggregate Offering Price</font></div>
          </td>
          <td style="width: 13.54%; vertical-align: bottom; border-bottom: 2px solid rgb(0, 0, 0); border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);">
            <div style="text-align: center;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif; font-weight: bold;">Amount of Registration Fee</font></div>
          </td>
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          <td style="width: 33.49%; vertical-align: top; border-bottom: #000000 2px solid;">
            <div style="text-align: left;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">Common Shares</font></div>
          </td>
          <td style="width: 13.88%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);">&#160;</td>
          <td style="width: 19.29%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);">&#160;</td>
          <td style="width: 19.81%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);">&#160;</td>
          <td style="width: 13.54%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);">&#160;</td>
        </tr>
        <tr>
          <td style="width: 33.49%; vertical-align: top; border-bottom: #000000 2px solid;">
            <div style="text-align: left;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">To be issued pursuant to stock options outstanding under the Option Plan and restricted stock units under the RSU Plan</font></div>
          </td>
          <td style="width: 13.88%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);">
            <div style="text-align: center; margin-right: 0.55pt;"><font style="font-size: 10pt; font-family: &quot;Times New Roman&quot;,Times,serif;">2,705,000</font></div>
          </td>
          <td style="width: 19.29%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);">
            <div style="text-align: center;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">$2.17</font></div>
          </td>
          <td style="width: 19.81%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);">
            <div style="text-align: center;"><font style="font-size: 10pt; font-family: &quot;Times New Roman&quot;,Times,serif;">$5,869,850</font></div>
          </td>
          <td style="width: 13.54%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);">
            <div style="text-align: center;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">$712</font></div>
          </td>
        </tr>

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    <div style="text-align: left; text-indent: -18pt; margin-left: 18pt;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">_______________</font></div>
    <div style="text-align: justify; text-indent: -18pt; margin-left: 18pt; font-size: 8pt;"><font style="font-family: &quot;Times New Roman&quot;,Times,serif;">(1)<font class="HorizontalTab" style="width: 9pt; font-size: 1px; display: inline-block;"> </font>Consists



        of common shares of the registrant (without par value) issuable upon the exercise of options granted pursuant to the Option Plan and the vesting of restricted stock units under the RSU Plan. Also includes such indeterminate number of common shares
        of the registrant as may be issued to prevent dilution resulting from stock dividends, stock splits or similar transactions in accordance with Rule 416 under the Securities Act of 1933.</font></div>
    <div style="text-align: justify; text-indent: -18pt; margin-left: 18pt; font-size: 8pt;"><font style="font-family: &quot;Times New Roman&quot;,Times,serif;">(2)<font class="HorizontalTab" style="width: 9pt; font-size: 1px; display: inline-block;"> </font>The



        proposed maximum offering price per share and the registration fee were calculated in accordance with Rule 457(c) and (h) based on the average high and low prices for the registrant&#8217;s common shares on December 11, 2018, as quoted on the NASDAQ
        Capital Market.</font></div>
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    <div style="text-align: center;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif; font-weight: bold;">INFORMATION REQUIRED PURSUANT</font></div>
    <div style="text-align: center;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif; font-weight: bold;">TO GENERAL INSTRUCTION E TO FORM S-8</font></div>
    <div><br>
    </div>
    <div style="text-align: justify; text-indent: 36pt;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">This registration statement is being filed by Aptose Biosciences Inc. in order to register 2,705,000 of its common shares
        issuable under Aptose&#8217;s Share Option Plan and 2015 Stock Incentive Plan.&#160; The common shares being registered are in addition to the 2,080,050 common shares previously registered on Aptose&#8217;s Registration Statement on Form S-8, filed on June 23, 2015
        (File No. 333-205158) (the &#8220;Prior Registration Statement&#8221;).</font></div>
    <div><br>
    </div>
    <div style="text-align: justify; text-indent: 36pt;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">This registration statement relates to securities of the same class as to which the Prior Registration Statement relates,
        and is submitted in accordance with General Instruction E to Form S-8 regarding the registration of additional securities. Accordingly, the contents of the Prior Registration Statement are incorporated herein by reference and made part of this
        registration statement, except as amended hereby.</font></div>
    <div><br>
    </div>
    <div style="text-align: center;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif; font-weight: bold;">PART I</font></div>
    <div><br>
    </div>
    <div style="text-align: center;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif; font-weight: bold;">INFORMATION REQUIRED IN THE SECTION 10(A) PROSPECTUS</font></div>
    <div><br>
    </div>
    <div style="text-align: justify; text-indent: 36pt;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">The documents containing the information specified in Part I of Form S-8 are not required to be filed with the Securities
        and Exchange Commission either as part of this registration statement or as prospectuses or prospectus supplements, pursuant to the Note to Part I of Form S-8 and Rule 424 under the Securities Act of 1933. The information required in the Section
        10(a) prospectus is included in documents being maintained and delivered by Aptose Biosciences Inc. as required by Part I of Form S-8 and by Rule 428 under the Securities Act of 1933.</font></div>
    <div><br>
    </div>
    <div style="text-align: center; text-indent: -72pt; margin-left: 72pt;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif; font-weight: bold;">PART II</font></div>
    <div><br>
    </div>
    <div style="text-align: center; text-indent: -72pt; margin-left: 72pt;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif; font-weight: bold;">INFORMATION REQUIRED IN THE REGISTRATION STATEMENT</font></div>
    <div><br>
    </div>
    <div style="text-align: justify;">
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              <td style="width: 72pt; vertical-align: top; align: right;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif; font-weight: bold;">Item 3.</font></td>
              <td style="width: auto; vertical-align: top; text-align: justify;">
                <div><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif; font-weight: bold;">Incorporation Of Documents By Reference.</font></div>
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      </div>
    </div>
    <div><br>
    </div>
    <div style="text-align: justify; text-indent: 36pt;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">The following documents that have been filed by us with the SEC are incorporated in this registration statement by
        reference:</font></div>
    <div><br>
    </div>
    <div>
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              <div style="text-align: left; margin-left: 36pt;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">(a)</font></div>
            </td>
            <td style="width: auto; vertical-align: top;">
              <div style="text-align: justify;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">Our Annual Report on Form 40-F for the fiscal year ended December 31, 2017, filed with the SEC on March 27, 2018.</font></div>
            </td>
          </tr>

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    </div>
    <div><br>
    </div>
    <div>
      <table cellspacing="0" cellpadding="0" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%;" class="DSPFListTable" id="z4afcf0c45c234b6fa32b1cfa91e69048">

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            <td style="width: 72pt; vertical-align: top; align: right;">
              <div style="text-align: left; margin-left: 36pt;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">(b)</font></div>
            </td>
            <td style="width: auto; vertical-align: top;">
              <div style="text-align: justify;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">Exhibits 99.1 and 99.2 to our Report of Foreign Issuer on Form 6-K containing interim financial statements and management&#8217;s
                  discussion and analysis, furnished to the SEC on May 10, 2018.</font></div>
            </td>
          </tr>

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    </div>
    <div><br>
    </div>
    <div>
      <table cellspacing="0" cellpadding="0" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%;" class="DSPFListTable" id="z1e42fbbb0baf46528f7a4bc9a5d5f9d8">

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            <td style="width: 72pt; vertical-align: top; align: right;">
              <div style="text-align: left; margin-left: 36pt;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">(c)</font></div>
            </td>
            <td style="width: auto; vertical-align: top;">
              <div style="text-align: justify;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">Exhibits 99.1 and 99.2 to our Report of Foreign Issuer on Form 6-K containing interim financial statements and management&#8217;s
                  discussion and analysis, furnished to the SEC on August 7, 2018.</font></div>
            </td>
          </tr>

      </table>
    </div>
    <div><br>
    </div>
    <div>
      <table cellspacing="0" cellpadding="0" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%;" class="DSPFListTable" id="zefa258125bad4c48b491e0dd032e8e33">

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            <td style="width: 72pt; vertical-align: top; align: right;">
              <div style="text-align: left; margin-left: 36pt;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">(d)</font></div>
            </td>
            <td style="width: auto; vertical-align: top;">
              <div style="text-align: justify;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">Exhibits 99.1 and 99.2 to our Report of Foreign Issuer on Form 6-K containing interim financial statements and management&#8217;s
                  discussion and analysis, furnished to the SEC on November 6, 2018.</font></div>
            </td>
          </tr>

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    </div>
    <div><br>
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      <div id="DSPFPageNumberArea" style="text-align: center;"><font id="DSPFPageNumber" style="font-family: 'Times New Roman', Times, serif; font-size: 8pt; font-weight: normal; font-style: normal;">1</font></div>
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    <div>
      <table cellspacing="0" cellpadding="0" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%;" class="DSPFListTable" id="zabc60549857445f3a93bd3ed9c62e899">

          <tr>
            <td style="width: 72pt; vertical-align: top; align: right;">
              <div style="text-align: left; margin-left: 36pt;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">(e)</font></div>
            </td>
            <td style="width: auto; vertical-align: top;">
              <div style="text-align: justify;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">Our Report of Foreign Issuer on Form 6-K furnished to the SEC on July 2, 2018.</font></div>
            </td>
          </tr>

      </table>
    </div>
    <div><br>
    </div>
    <div>
      <table cellspacing="0" cellpadding="0" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%;" class="DSPFListTable" id="z1b1df41b780b48aeb7f89f28f0afbcaf">

          <tr>
            <td style="width: 72pt; vertical-align: top; align: right;">
              <div style="text-align: left; margin-left: 36pt;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">(f)</font></div>
            </td>
            <td style="width: auto; vertical-align: top;">
              <div style="text-align: justify;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">Exhibit 99.1 to our Report of Foreign Issuer on Form 6-K furnished to the SEC on June 22, 2018.</font></div>
            </td>
          </tr>

      </table>
    </div>
    <div><br>
    </div>
    <div>
      <table cellspacing="0" cellpadding="0" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%;" class="DSPFListTable" id="z16a12b855e61420ba82d60940370f3a6">

          <tr>
            <td style="width: 72pt; vertical-align: top; align: right;">
              <div style="text-align: left; margin-left: 36pt;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">(g)</font></div>
            </td>
            <td style="width: auto; vertical-align: top;">
              <div style="text-align: justify;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">Our Report of Foreign Issuer on Form 6-K containing a material change report, furnished to the SEC on June 11, 2018.</font></div>
            </td>
          </tr>

      </table>
    </div>
    <div><br>
    </div>
    <div>
      <table cellspacing="0" cellpadding="0" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%;" class="DSPFListTable" id="z050009d1f2b044b5a0087a06ee6673c5">

          <tr>
            <td style="width: 72pt; vertical-align: top; align: right;">
              <div style="text-align: left; margin-left: 36pt;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">(h)</font></div>
            </td>
            <td style="width: auto; vertical-align: top;">
              <div style="text-align: justify;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">Our Report of Foreign Issuer on Form 6-K furnished to the SEC on May 9, 2018.</font></div>
            </td>
          </tr>

      </table>
    </div>
    <div><br>
    </div>
    <div>
      <table cellspacing="0" cellpadding="0" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%;" class="DSPFListTable" id="z6c159180abaf479681851eb7278b2a6c">

          <tr>
            <td style="width: 72pt; vertical-align: top; align: right;">
              <div style="text-align: left; margin-left: 36pt;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">(i)</font></div>
            </td>
            <td style="width: auto; vertical-align: top;">
              <div style="text-align: justify;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">Exhibit 99.1 to our Report of Foreign Issuer on Form 6-K containing a material change report furnished to the SEC on March 8, 2018.</font></div>
            </td>
          </tr>

      </table>
    </div>
    <div><br>
    </div>
    <div>
      <table cellspacing="0" cellpadding="0" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%;" class="DSPFListTable" id="zd770482396c9464f8f43ec8656fc8345">

          <tr>
            <td style="width: 72pt; vertical-align: top; align: right;">
              <div style="text-align: left; margin-left: 36pt;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">(j)</font></div>
            </td>
            <td style="width: auto; vertical-align: top;">
              <div style="text-align: justify;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">Our Report of Foreign Issuer on Form 6-K furnished to the SEC on February 1, 2018.</font></div>
            </td>
          </tr>

      </table>
    </div>
    <div><br>
    </div>
    <div>
      <table cellspacing="0" cellpadding="0" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%;" class="DSPFListTable" id="z420c429ee44d47888327268e8dc2fc29">

          <tr>
            <td style="width: 72pt; vertical-align: top; align: right;">
              <div style="text-align: left; margin-left: 36pt;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">(k)</font></div>
            </td>
            <td style="width: auto; vertical-align: top;">
              <div style="text-align: justify;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">All other reports filed by our company under Section 13(a) or 15(d) of the Securities Exchange Act of 1934 since December 31, 2017.</font></div>
            </td>
          </tr>

      </table>
    </div>
    <div><br>
    </div>
    <div>
      <table cellspacing="0" cellpadding="0" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%;" class="DSPFListTable" id="z7aa9950fe2eb4fee9d28501e0e10f975">

          <tr>
            <td style="width: 72pt; vertical-align: top; align: right;">
              <div style="text-align: left; margin-left: 36pt;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">(l)</font></div>
            </td>
            <td style="width: auto; vertical-align: top;">
              <div style="text-align: justify;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">The description of our common shares set forth under the heading &#8220;Additional Information &#8211; Common Shares&#8221; contained in our Annual
                  Report on Form 20-F for the fiscal year end May 31, 2014, filed with the SEC on July 30, 2014, and incorporated by reference into our Registration Statement on Form 8-A, as filed with the SEC on October 21, 2014, including any amendment
                  or report to such Registration Statement on Form 8-A filed for the purpose of amending such description.</font></div>
            </td>
          </tr>

      </table>
    </div>
    <div><br>
    </div>
    <div style="text-align: justify; text-indent: 36pt;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">In addition, all reports and documents filed by us under Section 13(a), 13(c), 14 or 15(d) of the Securities Exchange Act
        of 1934 after the date of this registration statement and prior to the filing of a post-effective amendment which indicates that all securities being offered have been sold or which deregisters all securities then remaining unsold, and any Form 6-K
        or Form 8-K furnished by us during such period or portions thereof that are identified in such Form 6-K or Form 8-K as being incorporated by reference into this registration statement, shall be deemed to be incorporated by reference in and to be
        part of this registration statement from the date of filing of each such document.</font></div>
    <div><br>
    </div>
    <div style="text-align: justify;">
      <div>
        <table cellspacing="0" cellpadding="0" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%;" class="DSPFListTable" id="z596a507e057d4486a00a8193c2ded352">

            <tr>
              <td style="width: 72pt; vertical-align: top; align: right;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif; font-weight: bold;">Item 8.</font></td>
              <td style="width: auto; vertical-align: top; text-align: justify;">
                <div><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif; font-weight: bold;">Exhibits.</font></div>
              </td>
            </tr>

        </table>
      </div>
    </div>
    <div><br>
    </div>
    <table cellspacing="0" cellpadding="0" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%;" id="zf97c0ad88ecc44e0bca1798e77f7aa59">

        <tr>
          <td style="width: 11.68%; vertical-align: top; border-bottom: 2px solid black;">
            <div style="text-align: center;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif; font-weight: bold;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">Exhibit</font></font></div>
          </td>
          <td style="width: 3.8%; vertical-align: top;">&#160;</td>
          <td style="width: 84.52%; vertical-align: top; border-bottom: 2px solid black;">
            <div style="text-align: justify;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif; font-weight: bold;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">Description of Exhibit</font></font></div>
          </td>
        </tr>
        <tr>
          <td style="width: 11.68%; vertical-align: top;">&#160;</td>
          <td style="width: 3.8%; vertical-align: top;">&#160;</td>
          <td style="width: 84.52%; vertical-align: top;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 11.68%; vertical-align: top;">
            <div style="text-align: center;"><a href="http://www.sec.gov/Archives/edgar/data/882361/000127956915001258/ex992.htm"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">4.1</font></a></div>
          </td>
          <td style="width: 3.8%; vertical-align: top;"><br>
          </td>
          <td style="width: 84.52%; vertical-align: top;">
            <div style="text-align: justify;"><a href="http://www.sec.gov/Archives/edgar/data/882361/000127956915001258/ex992.htm"><font style="font-size: 10pt; font-family: &quot;Times New Roman&quot;,Times,serif;">Aptose Biosciences Inc. Share Option
                  Plan. (incorporated by reference to Exhibit 99.2 to the Report of Foreign Issuer on Form 6-K of Aptose Biosciences Inc., furnished to the Securities and Exchange Commission on June 12, 2015)</font></a></div>
          </td>
        </tr>
        <tr>
          <td style="width: 11.68%; vertical-align: top;">&#160;</td>
          <td style="width: 3.8%; vertical-align: top;">&#160;</td>
          <td style="width: 84.52%; vertical-align: top;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 11.68%; vertical-align: top;">
            <div style="text-align: center;"><a href="http://www.sec.gov/Archives/edgar/data/882361/000127956915001258/ex991.htm"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">4.2</font></a></div>
          </td>
          <td style="width: 3.8%; vertical-align: top;"><br>
          </td>
          <td style="width: 84.52%; vertical-align: top;">
            <div style="text-align: justify;"><a href="http://www.sec.gov/Archives/edgar/data/882361/000127956915001258/ex991.htm"><font style="font-size: 10pt; font-family: &quot;Times New Roman&quot;,Times,serif;">Aptose Biosciences Inc. 2015 Stock
                  Incentive Plan (incorporated by reference to Exhibit 99.1 to the Report of Foreign Issuer on Form 6-K of Aptose Biosciences Inc., furnished to the Securities and Exchange Commission on June 12, 2015)</font></a></div>
          </td>
        </tr>

    </table>
    <div><br>
    </div>
    <div><br>
    </div>
    <div id="DSPFPageBreakArea" style="clear: both; margin-top: 10pt; margin-bottom: 10pt;">
      <div id="DSPFPageNumberArea" style="text-align: center;"><font id="DSPFPageNumber" style="font-family: 'Times New Roman', Times, serif; font-size: 8pt; font-weight: normal; font-style: normal;">2</font></div>
      <div id="DSPFPageBreak" style="page-break-after: always;">
        <hr noshade="noshade" style="border-width: 0px; clear: both; margin: 4px 0px; width: 100%; height: 2px; color: #000000; background-color: #000000;"></div>
    </div>
    <div>
      <table cellspacing="0" cellpadding="0" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%;">

          <tr>
            <td style="width: 11.71%; vertical-align: top; border-bottom: 2px solid black;">
              <div style="text-align: center;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif; font-weight: bold;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">Exhibit</font></font></div>
            </td>
            <td style="width: 3.8%; vertical-align: top;">&#160;</td>
            <td style="width: 84.49%; vertical-align: top; border-bottom: 2px solid black;">
              <div style="text-align: justify;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif; font-weight: bold;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">Description of Exhibit</font></font></div>
            </td>
          </tr>
          <tr>
            <td style="width: 11.71%; vertical-align: top;">&#160;</td>
            <td style="width: 3.8%; vertical-align: top;">&#160;</td>
            <td style="width: 84.49%; vertical-align: top;">&#160;</td>
          </tr>
          <tr>
            <td style="width: 11.71%; vertical-align: top;">
              <div style="text-align: center;"><a href="ex5_1.htm"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">5.1</font></a></div>
            </td>
            <td style="width: 3.8%; vertical-align: top;">&#160;</td>
            <td style="width: 84.49%; vertical-align: top;">
              <div style="text-align: left;"><a href="ex5_1.htm"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">Opinion
                    of McCarthy T&#233;trault LLP.</font></a></div>
            </td>
          </tr>
          <tr>
            <td style="width: 11.71%; vertical-align: top;">&#160;</td>
            <td style="width: 3.8%; vertical-align: top;">&#160;</td>
            <td style="width: 84.49%; vertical-align: top;">&#160;</td>
          </tr>
          <tr>
            <td style="width: 11.71%; vertical-align: top;">
              <div style="text-align: center;"><a href="ex23_1.htm"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">23.1</font></a></div>
            </td>
            <td style="width: 3.8%; vertical-align: top;">&#160;</td>
            <td style="width: 84.49%; vertical-align: top;">
              <div style="text-align: left;"><a href="ex23_1.htm"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">Consent
                    of KPMG LLP.</font></a></div>
            </td>
          </tr>
          <tr>
            <td style="width: 11.71%; vertical-align: top;">&#160;</td>
            <td style="width: 3.8%; vertical-align: top;">&#160;</td>
            <td style="width: 84.49%; vertical-align: top;">&#160;</td>
          </tr>
          <tr>
            <td style="width: 11.71%; vertical-align: top;">
              <div style="text-align: center;"><a href="ex5_1.htm"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">23.2</font></a></div>
            </td>
            <td style="width: 3.8%; vertical-align: top;">&#160;</td>
            <td style="width: 84.49%; vertical-align: top;">
              <div style="text-align: left;"><a href="ex5_1.htm"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">Consent
                    of McCarthy T&#233;trault LLP (included in Exhibit 5.1).</font></a></div>
            </td>
          </tr>
          <tr>
            <td style="width: 11.71%; vertical-align: top;">&#160;</td>
            <td style="width: 3.8%; vertical-align: top;">&#160;</td>
            <td style="width: 84.49%; vertical-align: top;">&#160;</td>
          </tr>
          <tr>
            <td style="width: 11.71%; vertical-align: top;">
              <div style="text-align: center;"><a href="#POA"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">24.1</font></a></div>
            </td>
            <td style="width: 3.8%; vertical-align: top;">&#160;</td>
            <td style="width: 84.49%; vertical-align: top;">
              <div style="text-align: left;"><a href="#POA"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">Powers of Attorney (included on the signature pages to this registration statement).</font></a></div>
            </td>
          </tr>

      </table>
    </div>
    <div style="clear: both; margin-top: 10pt; margin-bottom: 10pt;" id="DSPFPageBreakArea">
      <div id="DSPFPageNumberArea" style="text-align: center;"><font id="DSPFPageNumber" style="font-family: 'Times New Roman', Times, serif; font-size: 8pt; font-weight: normal; font-style: normal;">3</font></div>
      <div style="page-break-after:always;" id="DSPFPageBreak">
        <hr noshade="noshade" style="margin: 4px 0px; width: 100%; border-width: 0; height: 2px; color: #000000; background-color: #000000; clear: both;"></div>
    </div>
    <div style="text-align: center;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif; font-weight: bold;">SIGNATURES</font></div>
    <div><br>
    </div>
    <div style="text-align: justify; text-indent: 36pt;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">Pursuant to the requirements of the Securities Act of 1933, Aptose Biosciences Inc. certifies that it has reasonable
        grounds to believe that it meets all of the requirements for filing on Form S-8 and has duly caused this registration statement to be signed on its behalf by the undersigned, thereunto duly authorized in the City of San Francisco, on this <font style="font-family: Times New Roman">13</font>th day of December, 2018.</font></div>
    <br>
    <div>
      <table cellspacing="0" cellpadding="0" border="0" id="z1e47cff6b5344735b3d190f57060d5f8" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%;">

          <tr>
            <td style="width: 60%;">
              <div>&#160;</div>
            </td>
            <td style="width: 40%;">
              <div><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif; font-weight: bold;">APTOSE BIOSCIENCES INC.</font></font></div>
              <div><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif; font-weight: bold;"> <br>
                  </font></font></div>
              <div><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif; font-weight: bold;"> <br>
                  </font></font></div>
              <div>By: <u>/s/ Gregory K. Chow&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; &#160; &#160; &#160; &#160; </u></div>
              <div>&#160;&#160;&#160;&#160;&#160;&#160; Gregory K. Chow</div>
              <div>&#160;&#160;&#160;&#160;&#160;&#160; Senior Vice President and Chief Financial Officer</div>
            </td>
          </tr>

      </table>
    </div>
    <br>
    <div><br>
    </div>
    <div style="clear: both; margin-top: 10pt; margin-bottom: 10pt;" id="DSPFPageBreakArea">
      <div id="DSPFPageNumberArea" style="text-align: center;"><font id="DSPFPageNumber" style="font-family: 'Times New Roman', Times, serif; font-size: 8pt; font-weight: normal; font-style: normal;">4</font></div>
      <div style="page-break-after:always;" id="DSPFPageBreak">
        <hr noshade="noshade" style="margin: 4px 0px; width: 100%; border-width: 0; height: 2px; color: #000000; background-color: #000000; clear: both;"></div>
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    <div style="text-align: center;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif; font-weight: bold;"><a name="POA"><!--Anchor--></a>POWERS OF ATTORNEY</font></div>
    <div><br>
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    <div style="text-align: justify; text-indent: 36pt;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">KNOW ALL PERSONS BY THESE PRESENTS, that each person whose signature appears below hereby constitutes and appoints William
        G. Rice and Gregory K. Chow, and each of them, his true and lawful attorneys-in-fact and agents, each acting alone, with the powers of substitution and revocation, for him and in his name, place and stead, in any and all capacities, to sign this
        Registration Statement on Form S-8, and any and all amendments (including post-effective amendments) thereto, and to file the same, with all exhibits thereto and other documents in connection therewith, with the Securities and Exchange Commission,
        granting unto such attorneys-in-fact and agents, and each of them, full power and authority to do and perform each and every act and thing requisite or necessary to be done in and about the premises, as fully to all intents and purposes as he might
        or could do in person, hereby ratifying and confirming that all such attorneys-in-fact and agents or any of them, or their substitute or substitutes, may lawfully do or cause to be done by virtue hereof.</font></div>
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    <div style="text-align: justify; text-indent: 36pt;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">Pursuant to the requirements of the Securities Act of 1933, this registration statement has been signed by the following
        persons in the capacities indicated below on December <font style="font-family: Times New Roman">13</font>, 2018.</font></div>
    <div><br>
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    <table cellspacing="0" cellpadding="0" border="0" style="width: 70%; font-family: 'Times New Roman', Times, serif; font-size: 10pt;" id="zfdb57753a8994795af920463f8914363">

        <tr>
          <td style="width: 40%; vertical-align: top;">
            <div style="text-align: left;"><u><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif; font-weight: bold;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">Signature</font></font></u></div>
            <div>&#160;</div>
          </td>
          <td style="width: 5%; vertical-align: top;">&#160;</td>
          <td style="width: 25%; vertical-align: top;">
            <div style="text-align: left;"><u><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif; font-weight: bold;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">Title</font></font></u></div>
            <div>&#160;</div>
          </td>
        </tr>
        <tr>
          <td style="width: 40%; vertical-align: top;">&#160;</td>
          <td style="width: 5%; vertical-align: top;">&#160;</td>
          <td style="width: 25%; vertical-align: top;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 40%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0);">/s/ William G. Rice<br>
          </td>
          <td style="width: 5%; vertical-align: top; padding-bottom: 2px;">&#160;</td>
          <td style="width: 25%; vertical-align: top; padding-bottom: 2px;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 40%; vertical-align: top;">
            <div style="text-align: left;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">William G. Rice</font></div>
          </td>
          <td style="width: 5%; vertical-align: top;">&#160;</td>
          <td style="width: 25%; vertical-align: top;">
            <div style="text-align: justify;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">President, Chief Executive Officer and Chairman of the Board of Directors (Principal Executive Officer)</font></div>
          </td>
        </tr>
        <tr>
          <td style="width: 40%; vertical-align: top;">&#160;</td>
          <td style="width: 5%; vertical-align: top;">&#160;</td>
          <td style="width: 25%; vertical-align: top;">&#160;</td>
        </tr>
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          <td style="width: 40%; vertical-align: top;">&#160;</td>
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            <td rowspan="1" style="width: 5%; vertical-align: top; padding-bottom: 2px;">&#160;</td>
            <td rowspan="1" style="width: 25%; vertical-align: top; padding-bottom: 2px;">&#160;</td>
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    <div style="text-align: center;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif; font-weight: bold;">AUTHORIZED REPRESENTATIVE</font></div>
    <div style="text-align: center;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif; font-weight: bold;"> <br>
      </font></div>
    <div style="text-align: left; text-indent: 36pt; margin-bottom: 12pt;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">Pursuant to the requirements of Section&#160;6(a) of the Securities Act of 1933, the undersigned has signed
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    </div>
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      <div>
        <table cellspacing="0" cellpadding="0" border="0" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%;">

            <tr>
              <td style="width: 60%;">
                <div>&#160;</div>
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                <div><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif; font-weight: bold;">APTOSE BIOSCIENCES INC.</font></font></div>
                <div><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif; font-weight: bold;"> <br>
                    </font></font></div>
                <div><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif; font-weight: bold;"> <br>
                    </font></font></div>
                <div>By: <u>/s/ Gregory K. Chow&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; &#160; &#160; &#160; &#160; </u></div>
                <div>&#160;&#160;&#160;&#160;&#160;&#160; Gregory K. Chow</div>
                <div>&#160;&#160;&#160;&#160;&#160;&#160; Senior Vice President and Chief Financial Officer</div>
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    <!--PROfilePageNumberReset%Num%8%%%-->
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    <div style="text-align: center;"><font style="font-weight: bold;">EXHIBIT INDEX</font><br>
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    <div style="text-align: center;"> <br>
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    <div style="text-align: left;">
      <table cellspacing="0" cellpadding="0" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%;">

          <tr>
            <td style="width: 11.68%; vertical-align: top; border-bottom: 2px solid black;">
              <div style="text-align: center;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif; font-weight: bold;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">Exhibit</font></font></div>
            </td>
            <td style="width: 3.8%; vertical-align: top;">&#160;</td>
            <td style="width: 84.52%; vertical-align: top; border-bottom: 2px solid black;">
              <div style="text-align: justify;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif; font-weight: bold;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">Description of Exhibit</font></font></div>
            </td>
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            <td style="width: 11.68%; vertical-align: top;">&#160;</td>
            <td style="width: 3.8%; vertical-align: top;">&#160;</td>
            <td style="width: 84.52%; vertical-align: top;">&#160;</td>
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            <td style="width: 11.68%; vertical-align: top;">
              <div style="text-align: center;"><a href="http://www.sec.gov/Archives/edgar/data/882361/000127956915001258/ex992.htm"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">4.1</font></a></div>
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              <div style="text-align: justify;"><a href="http://www.sec.gov/Archives/edgar/data/882361/000127956915001258/ex992.htm"><font style="font-size: 10pt; font-family: &quot;Times New Roman&quot;,Times,serif;">Aptose Biosciences Inc. Share Option
                    Plan. (incorporated by reference to Exhibit 99.2 to the Report of Foreign Issuer on Form 6-K of Aptose Biosciences Inc., furnished to the Securities and Exchange Commission on June 12, 2015)</font></a></div>
            </td>
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            <td style="width: 11.68%; vertical-align: top;">&#160;</td>
            <td style="width: 3.8%; vertical-align: top;">&#160;</td>
            <td style="width: 84.52%; vertical-align: top;">&#160;</td>
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            <td rowspan="1" style="width: 11.68%; vertical-align: top; text-align: center;"><a href="http://www.sec.gov/Archives/edgar/data/882361/000127956915001258/ex991.htm"><font style="font-size: 10pt; font-family: &quot;Times New
                  Roman&quot;,Times,serif;">4.2</font></a></td>
            <td rowspan="1" style="width: 3.8%; vertical-align: top;">&#160;</td>
            <td rowspan="1" style="width: 84.52%; vertical-align: top; text-align: justify;"><a href="http://www.sec.gov/Archives/edgar/data/882361/000127956915001258/ex991.htm"><font style="font-size: 10pt; font-family: &quot;Times New
                  Roman&quot;,Times,serif;">Aptose Biosciences Inc. 2015 Stock Incentive Plan (incorporated by reference to Exhibit 99.1 to the Report of Foreign Issuer on Form 6-K of Aptose Biosciences Inc., furnished to the Securities and Exchange
                  Commission on June 12, 2015)</font></a></td>
          </tr>

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      <div>
        <table cellspacing="0" cellpadding="0" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%;">

            <tr>
              <td style="width: 11.71%; vertical-align: top;">&#160;</td>
              <td style="width: 3.8%; vertical-align: top;">&#160;</td>
              <td style="width: 84.49%; vertical-align: top;">&#160;</td>
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              <td style="width: 11.71%; vertical-align: top;">
                <div style="text-align: center;"><a href="ex5_1.htm"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">5.1</font></a></div>
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                <div style="text-align: left;"><a href="ex5_1.htm"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">Opinion


                      of McCarthy T&#233;trault LLP.</font></a></div>
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              <td style="width: 11.71%; vertical-align: top;">&#160;</td>
              <td style="width: 3.8%; vertical-align: top;">&#160;</td>
              <td style="width: 84.49%; vertical-align: top;">&#160;</td>
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              <td style="width: 11.71%; vertical-align: top;">
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                <div style="text-align: left;"><a href="ex23_1.htm"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">Consent


                      of KPMG LLP.</font></a></div>
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              <td style="width: 11.71%; vertical-align: top;">&#160;</td>
              <td style="width: 3.8%; vertical-align: top;">&#160;</td>
              <td style="width: 84.49%; vertical-align: top;">&#160;</td>
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              <td style="width: 11.71%; vertical-align: top;">
                <div style="text-align: center;"><a href="ex5_1.htm"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">23.2</font></a></div>
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              <td style="width: 3.8%; vertical-align: top;">&#160;</td>
              <td style="width: 84.49%; vertical-align: top;">
                <div style="text-align: left;"><a href="ex5_1.htm"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">Consent


                      of McCarthy T&#233;trault LLP (included in Exhibit 5.1).</font></a></div>
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              <td style="width: 11.71%; vertical-align: top;">&#160;</td>
              <td style="width: 3.8%; vertical-align: top;">&#160;</td>
              <td style="width: 84.49%; vertical-align: top;">&#160;</td>
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              <td style="width: 11.71%; vertical-align: top;">
                <div style="text-align: center;"><a href="#POA"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">24.1</font></a></div>
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                <div style="text-align: left;"><a href="#POA"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">Powers of Attorney (included on the signature pages to this registration statement).</font></a></div>
              </td>
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As filed with the Securities and Exchange Commission on December 13, 2018.
Registration No. 333-
UNITED STATES
SECURITIES AND EXCHANGE COMMISSION
WASHINGTON, D.C. 20549
____________
FORM S-8
REGISTRATION STATEMENT UNDER THE
SECURITIES ACT OF 1933
____________
APTOSE BIOSCIENCES INC.
(Exact name of registrant as specified in its charter)
Canada
(State or Other Jurisdiction of
Incorporation or Organization)
98-1136802
(I.R.S. Employer
Identification No.)
____________
251 Consumers Road, Suite 1105, Toronto, Ontario, Canada M2J 4R3
(Address of Principal Executive Offices)
____________
Aptose Biosciences Inc. Share Option Plan ("Option Plan")
Aptose Biosciences Inc. 2015 Stock Incentive Plan ("RSU Plan")
(Full title of the plan)
____________
Aptose Biosciences U.S. Inc.
12270 High Bluff Drive, Suite 120
San Diego, California 92130
(Name, address and telephone number, including area code, of agent for service)
____________
Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, a
                non-accelerated filer, or a smaller reporting company. See the definitions of "large accelerated filer," "accelerated filer" and "smaller reporting company" in Rule 12b-2 of the Exchange Act. (Check one):
Large accelerated filer ☐
Accelerated filer ☐
Non-accelerated filer ☐ (Do not check if a smaller reporting company)
Smaller reporting company ☒
____________
CALCULATION OF REGISTRATION FEE
Title of Securities
To Be Registered
Amount To Be
Registered (1)
Proposed Maximum Offering Price
Per Share (2)
Proposed Maximum Aggregate Offering Price
Amount of Registration Fee
Common Shares
To be issued pursuant to stock options outstanding under the Option Plan and restricted stock units under the RSU Plan
2,705,000
$2.17
$5,869,850
$712
_______________
(1)
Consists

        of common shares of the registrant (without par value) issuable upon the exercise of options granted pursuant to the Option Plan and the vesting of restricted stock units under the RSU Plan. Also includes such indeterminate number of common shares
        of the registrant as may be issued to prevent dilution resulting from stock dividends, stock splits or similar transactions in accordance with Rule 416 under the Securities Act of 1933.
(2)
The

        proposed maximum offering price per share and the registration fee were calculated in accordance with Rule 457(c) and (h) based on the average high and low prices for the registrant's common shares on December 11, 2018, as quoted on the NASDAQ
        Capital Market.
INFORMATION REQUIRED PURSUANT
TO GENERAL INSTRUCTION E TO FORM S-8
This registration statement is being filed by Aptose Biosciences Inc. in order to register 2,705,000 of its common shares
        issuable under Aptose's Share Option Plan and 2015 Stock Incentive Plan.  The common shares being registered are in addition to the 2,080,050 common shares previously registered on Aptose's Registration Statement on Form S-8, filed on June 23, 2015
        (File No. 333-205158) (the "Prior Registration Statement").
This registration statement relates to securities of the same class as to which the Prior Registration Statement relates,
        and is submitted in accordance with General Instruction E to Form S-8 regarding the registration of additional securities. Accordingly, the contents of the Prior Registration Statement are incorporated herein by reference and made part of this
        registration statement, except as amended hereby.
PART I
INFORMATION REQUIRED IN THE SECTION 10(A) PROSPECTUS
The documents containing the information specified in Part I of Form S-8 are not required to be filed with the Securities
        and Exchange Commission either as part of this registration statement or as prospectuses or prospectus supplements, pursuant to the Note to Part I of Form S-8 and Rule 424 under the Securities Act of 1933. The information required in the Section
        10(a) prospectus is included in documents being maintained and delivered by Aptose Biosciences Inc. as required by Part I of Form S-8 and by Rule 428 under the Securities Act of 1933.
PART II
INFORMATION REQUIRED IN THE REGISTRATION STATEMENT
Item 3.
Incorporation Of Documents By Reference.
The following documents that have been filed by us with the SEC are incorporated in this registration statement by
        reference:
(a)
Our Annual Report on Form 40-F for the fiscal year ended December 31, 2017, filed with the SEC on March 27, 2018.
(b)
Exhibits 99.1 and 99.2 to our Report of Foreign Issuer on Form 6-K containing interim financial statements and management's
                  discussion and analysis, furnished to the SEC on May 10, 2018.
(c)
Exhibits 99.1 and 99.2 to our Report of Foreign Issuer on Form 6-K containing interim financial statements and management's
                  discussion and analysis, furnished to the SEC on August 7, 2018.
(d)
Exhibits 99.1 and 99.2 to our Report of Foreign Issuer on Form 6-K containing interim financial statements and management's
                  discussion and analysis, furnished to the SEC on November 6, 2018.
1
(e)
Our Report of Foreign Issuer on Form 6-K furnished to the SEC on July 2, 2018.
(f)
Exhibit 99.1 to our Report of Foreign Issuer on Form 6-K furnished to the SEC on June 22, 2018.
(g)
Our Report of Foreign Issuer on Form 6-K containing a material change report, furnished to the SEC on June 11, 2018.
(h)
Our Report of Foreign Issuer on Form 6-K furnished to the SEC on May 9, 2018.
(i)
Exhibit 99.1 to our Report of Foreign Issuer on Form 6-K containing a material change report furnished to the SEC on March 8, 2018.
(j)
Our Report of Foreign Issuer on Form 6-K furnished to the SEC on February 1, 2018.
(k)
All other reports filed by our company under Section 13(a) or 15(d) of the Securities Exchange Act of 1934 since December 31, 2017.
(l)
The description of our common shares set forth under the heading "Additional Information – Common Shares" contained in our Annual
                  Report on Form 20-F for the fiscal year end May 31, 2014, filed with the SEC on July 30, 2014, and incorporated by reference into our Registration Statement on Form 8-A, as filed with the SEC on October 21, 2014, including any amendment
                  or report to such Registration Statement on Form 8-A filed for the purpose of amending such description.
In addition, all reports and documents filed by us under Section 13(a), 13(c), 14 or 15(d) of the Securities Exchange Act
        of 1934 after the date of this registration statement and prior to the filing of a post-effective amendment which indicates that all securities being offered have been sold or which deregisters all securities then remaining unsold, and any Form 6-K
        or Form 8-K furnished by us during such period or portions thereof that are identified in such Form 6-K or Form 8-K as being incorporated by reference into this registration statement, shall be deemed to be incorporated by reference in and to be
        part of this registration statement from the date of filing of each such document.
Item 8.
Exhibits.
Exhibit
Description of Exhibit
4.1
Aptose Biosciences Inc. Share Option
                  Plan. (incorporated by reference to Exhibit 99.2 to the Report of Foreign Issuer on Form 6-K of Aptose Biosciences Inc., furnished to the Securities and Exchange Commission on June 12, 2015)
4.2
Aptose Biosciences Inc. 2015 Stock
                  Incentive Plan (incorporated by reference to Exhibit 99.1 to the Report of Foreign Issuer on Form 6-K of Aptose Biosciences Inc., furnished to the Securities and Exchange Commission on June 12, 2015)
2
Exhibit
Description of Exhibit
5.1
Opinion
                    of McCarthy Tétrault LLP.
23.1
Consent
                    of KPMG LLP.
23.2
Consent
                    of McCarthy Tétrault LLP (included in Exhibit 5.1).
24.1
Powers of Attorney (included on the signature pages to this registration statement).
3
SIGNATURES
Pursuant to the requirements of the Securities Act of 1933, Aptose Biosciences Inc. certifies that it has reasonable
        grounds to believe that it meets all of the requirements for filing on Form S-8 and has duly caused this registration statement to be signed on its behalf by the undersigned, thereunto duly authorized in the City of San Francisco, on this
13
th day of December, 2018.
APTOSE BIOSCIENCES INC.
By:
/s/ Gregory K. Chow
Gregory K. Chow
Senior Vice President and Chief Financial Officer
4
POWERS OF ATTORNEY
KNOW ALL PERSONS BY THESE PRESENTS, that each person whose signature appears below hereby constitutes and appoints William
        G. Rice and Gregory K. Chow, and each of them, his true and lawful attorneys-in-fact and agents, each acting alone, with the powers of substitution and revocation, for him and in his name, place and stead, in any and all capacities, to sign this
        Registration Statement on Form S-8, and any and all amendments (including post-effective amendments) thereto, and to file the same, with all exhibits thereto and other documents in connection therewith, with the Securities and Exchange Commission,
        granting unto such attorneys-in-fact and agents, and each of them, full power and authority to do and perform each and every act and thing requisite or necessary to be done in and about the premises, as fully to all intents and purposes as he might
        or could do in person, hereby ratifying and confirming that all such attorneys-in-fact and agents or any of them, or their substitute or substitutes, may lawfully do or cause to be done by virtue hereof.
Pursuant to the requirements of the Securities Act of 1933, this registration statement has been signed by the following
        persons in the capacities indicated below on December
13
, 2018.
Signature
Title
/s/ William G. Rice
William G. Rice
President, Chief Executive Officer and Chairman of the Board of Directors (Principal Executive Officer)
/s/ Gregory K. Chow
Gregory K. Chow
Senior Vice President and Chief Financial Officer (Principal Financial Officer and Principal Accounting Officer)
/s/ Dennis Burger
Dr. Dennis Burger
Director
/s/ Carol Ashe
Carol Ashe
Director
/s/ Caroline Loewy
Caroline Loewy
Director
5
Signature
Title
/s/ Erich M. Platzer
Dr. Erich M. Platzer
Director
/s/ Mark Vincent
Dr. Mark Vincent
Director
/s/ Warren Whitehead
Warren Whitehead
Director
6
AUTHORIZED REPRESENTATIVE
Pursuant to the requirements of Section 6(a) of the Securities Act of 1933, the undersigned has signed
        this registration statement, solely in the capacity of the duly authorized representative of Aptose Biosciences Inc. in the United States, on December 13
, 2018.
APTOSE BIOSCIENCES INC.
By:
/s/ Gregory K. Chow
Gregory K. Chow
Senior Vice President and Chief Financial Officer
7
EXHIBIT INDEX
Exhibit
Description of Exhibit
4.1
Aptose Biosciences Inc. Share Option
                    Plan. (incorporated by reference to Exhibit 99.2 to the Report of Foreign Issuer on Form 6-K of Aptose Biosciences Inc., furnished to the Securities and Exchange Commission on June 12, 2015)
4.2
Aptose Biosciences Inc. 2015 Stock Incentive Plan (incorporated by reference to Exhibit 99.1 to the Report of Foreign Issuer on Form 6-K of Aptose Biosciences Inc., furnished to the Securities and Exchange
                  Commission on June 12, 2015)
5.1
Opinion

                      of McCarthy Tétrault LLP.
23.1
Consent

                      of KPMG LLP.
23.2
Consent

                      of McCarthy Tétrault LLP (included in Exhibit 5.1).
24.1
Powers of Attorney (included on the signature pages to this registration statement).