As filed with the Securities and
Exchange Commission on May 31, 2000                       Registration No. 333-
================================================================================

                       SECURITIES AND EXCHANGE COMMISSION
                             WASHINGTON, D.C. 20549

                                    FORM S-8

                             REGISTRATION STATEMENT
                        UNDER THE SECURITIES ACT OF 1933

                       BIOJECT MEDICAL TECHNOLOGIES, INC.
             (Exact name of Registrant as specified in its charter)

           Oregon                                     93-1099680
-------------------------------             ------------------------------------
(State or other jurisdiction of             (I.R.S. Employer Identification No.)
Incorporation or organization)

                            7620 S.W. Bridgeport Road
                               Portland, OR 97224
                     --------------------------------------
                     Address of Principal Executive Offices

                                 (503) 639-7221
              ----------------------------------------------------
              (Registrant's Telephone Number, Including Area Code)

          Bioject Medical Technologies, Inc. 1992 Stock Incentive Plan
          ------------------------------------------------------------
                            (Full Title of the Plan)

                                 James C. O'Shea
                             Chief Executive Officer
                            7620 S.W. Bridgeport Road
                             Portland, Oregon 97224
                        ---------------------------------------
                        (Name and Address of Agent For Service)

                                     (503) 639-7221
              ------------------------------------------------------------
             (Telephone Number, Including Area Code, of Agent For Service)

<TABLE>

                         CALCULATION OF REGISTRATION FEE

=================================================================================================================================
                                                                Proposed Maximum        Proposed Maximum
     Title of Each Class of               Amount to            Offering Price Per      Aggregate Offering         Amount of
   Securities to be Registered         be Registered(1)             Share(2)                  Price          Registration Fee(1)
---------------------------------------------------------------------------------------------------------------------------------
<S>                                     <C>                          <C>                   <C>                     <C>
Common Shares,                          300,000 shares               $8.6875               $2,606,250              $688.05
no par value
=================================================================================================================================
</TABLE>

(1)  To be offered by The Company pursuant to the Plan described herein.

(2)  The proposed maximum offering price per share and the registration fee were
     calculated in  accordance  with rule 457(c) and (h) based on the average of
     the high and low prices for shares of the registrant's  Common Stock on May
     23,  2000 as quoted by the Nasdaq  SmallCap  Market,  which was $8.6875 per
     share.

================================================================================


<PAGE>


           PART II. INFORMATION REQUIRED IN THE REGISTRATION STATEMENT

                      REGISTRATION OF ADDITIONAL SECURITIES

     Pursuant to General Instruction E, this Registration  Statement on Form S-8
is filed by Bioject Medical  Technologies,  Inc. (the  "Registrant") to register
additional  securities under the Bioject Medical  Technologies,  Inc. 1992 Stock
Incentive Plan (the "Plan") covered by the Registrant's  Registration  Statement
on Form S-8 (No.  33-42156),  as amended.  The  additional  securities are to be
issued pursuant to an amendment to the Plan approved by the  Registrant's  Board
of Directors on September 10, 1997 and on July 28, 1998, and by the Registrant's
Shareholders  on September  10, 1998.  Portions of  Registration  Statement  No.
33-94400, 33-56454 and 33-42156 are incorporated herein by reference.

Item 8.  Exhibits.

Exhibit Number          Exhibit
--------------          -------
    4.1*                Bioject Medical Technologies, Inc. 1992 Stock Incentive
                        Plan, as amended

    5.1                 Opinion of Dorsey & Whitney LLP

   23.1                 Consent of Dorsey & Whitney LLP
                        (included in Exhibit 5.1)

   23.2                 Consent of Independent Public Accountants

   24.1                 Power of Attorney (See page II-6 of this Registration
                        Statement)
--------------------

*    Incorporated by reference to Exhibit 4.3 of the Company's Form 10-Q for the
     period ended December 31, 1997.











                                       2
<PAGE>

                                   SIGNATURES

     Pursuant to the  requirements of the Securities Act of 1933, the registrant
certifies  that it has  reasonable  grounds to believe  that it meets all of the
requirements  for  filing  on Form S-8 and has  duly  caused  this  registration
statement  to be  signed  on its  behalf  by  the  undersigned,  thereunto  duly
authorized, in the City of Portland, Oregon, on this 26th day of August, 1999.

                                    BIOJECT MEDICAL TECHNOLOGIES INC.


                                    By: /s/ James C. O'Shea
                                        ----------------------------------------
                                        James C. O'Shea
                                        Chairman of the Board, Chief Executive
                                          Officer and President


                                POWER OF ATTORNEY

     Each person whose signature appears below constitutes and appoints James C.
O'Shea and Michael A. Temple, or either of them, his attorney-in-fact,  with the
power  of  substitution,  for  them  in any  and all  capacities,  to  sign  any
amendments to this registration  statement,  and to file the same, with exhibits
thereto and other  documents in connection  therewith,  with the  Securities and
Exchange   Commission,   hereby   ratifying   and   confirming   all  that  said
attorneys-in-fact,  or their  substitute or  substitutes,  may do or cause to be
done by virtue hereof.

     Pursuant  to  the   requirements  of  the  Securities  Act  of  1933,  this
registration  statement  has  been  signed  by  the  following  persons  in  the
capacities and on the date indicated.

Signature                    Title                            Date
---------                    -----                            ----


/s/ James C. O'Shea          Chairman of the Board            May 25, 2000
-----------------------      Chief Executive Officer
James C. O'Shea              and President (Principal
                             Executive, Accounting and
                             Financial Officer)


/s/ William A. Gouveia       Director                         May 31, 2000
-----------------------
William A. Gouveia


/s/ John Ruedy, M.D.         Director                         May 26, 2000
-----------------------
John Ruedy, M.D.


                             Director
-----------------------
Grace Keeney Fey


/s/ Eric T. Herfindal        Director                         May 30, 2000
-----------------------
Eric T. Herfindal


/s/ Richard J. Plestina      Director                         May 27, 2000
-----------------------
Richard J. Plestina


                             Director
-----------------------
David H. de Weese


/s/ Edward Flynn             Director                         May 31, 2000
-----------------------
Edward Flynn


                                       3
<PAGE>


                                  EXHIBIT INDEX

Exhibit
Number           Exhibit                                               Page
------           -------                                               ----

 4.1*            Bioject Medical Technologies, Inc.
                 1992 Stock Option Plan

 5.1             Opinion of Dorsey & Whitney LLP

23.1             Consent of Dorsey & Whitney LLP
                 (included in Exhibit 5.1)

23.2             Consent of Independent Public Accountants

24.1             Power of Attorney (See page II-6 of
                 this Registration Statement)
--------------------

*    Incorporated by reference to Exhibit 4.3 of the Company's Form 10-Q for the
     period ended December 31, 1997.
[{"type": "S-8", "sequence": "1", "filename": "0001.txt", "description": "REGISTRATION STATEMENT", "secsgml_size_bytes": 8857}]
{"company-data": {"conformed-name": "BIOJECT MEDICAL TECHNOLOGIES INC", "cik": "0000810084", "assigned-sic": "3841", "irs-number": "931099680", "state-of-incorporation": "OR", "fiscal-year-end": "0331"}, "filing-values": {"form-type": "S-8", "act": "33", "file-number": "333-38212", "film-number": "647217"}, "business-address": {"street1": "7620 S W BRIDGEPORT RD", "city": "PORTLAND", "state": "OR", "zip": "97224", "phone": "5036397221"}, "mail-address": {"street1": "7620 S W BRIDGEPORT ROAD", "city": "PORTLAND", "state": "OR", "zip": "97224"}, "former-company": {"former-conformed-name": "BIOJECT MEDICAL SYSTEMS LTD", "date-changed": "19920703"}}
As filed with the Securities and
Exchange Commission on May 31, 2000                       Registration No. 333-
================================================================================

                       SECURITIES AND EXCHANGE COMMISSION
                             WASHINGTON, D.C. 20549

                                    FORM S-8

                             REGISTRATION STATEMENT
                        UNDER THE SECURITIES ACT OF 1933

                       BIOJECT MEDICAL TECHNOLOGIES, INC.
             (Exact name of Registrant as specified in its charter)

           Oregon                                     93-1099680
-------------------------------             ------------------------------------
(State or other jurisdiction of             (I.R.S. Employer Identification No.)
Incorporation or organization)

                            7620 S.W. Bridgeport Road
                               Portland, OR 97224
                     --------------------------------------
                     Address of Principal Executive Offices

                                 (503) 639-7221
              ----------------------------------------------------
              (Registrant's Telephone Number, Including Area Code)

          Bioject Medical Technologies, Inc. 1992 Stock Incentive Plan
          ------------------------------------------------------------
                            (Full Title of the Plan)

                                 James C. O'Shea
                             Chief Executive Officer
                            7620 S.W. Bridgeport Road
                             Portland, Oregon 97224
                        ---------------------------------------
                        (Name and Address of Agent For Service)

                                     (503) 639-7221
              ------------------------------------------------------------
             (Telephone Number, Including Area Code, of Agent For Service)

                         CALCULATION OF REGISTRATION FEE

=================================================================================================================================
                                                                Proposed Maximum        Proposed Maximum
     Title of Each Class of               Amount to            Offering Price Per      Aggregate Offering         Amount of
   Securities to be Registered         be Registered(1)             Share(2)                  Price          Registration Fee(1)
---------------------------------------------------------------------------------------------------------------------------------
Common Shares,                          300,000 shares               $8.6875               $2,606,250              $688.05
no par value
=================================================================================================================================
(1)  To be offered by The Company pursuant to the Plan described herein.

(2)  The proposed maximum offering price per share and the registration fee were
     calculated in  accordance  with rule 457(c) and (h) based on the average of
     the high and low prices for shares of the registrant's  Common Stock on May
     23,  2000 as quoted by the Nasdaq  SmallCap  Market,  which was $8.6875 per
     share.

================================================================================
PART II. INFORMATION REQUIRED IN THE REGISTRATION STATEMENT

                      REGISTRATION OF ADDITIONAL SECURITIES

     Pursuant to General Instruction E, this Registration  Statement on Form S-8
is filed by Bioject Medical  Technologies,  Inc. (the  "Registrant") to register
additional  securities under the Bioject Medical  Technologies,  Inc. 1992 Stock
Incentive Plan (the "Plan") covered by the Registrant's  Registration  Statement
on Form S-8 (No.  33-42156),  as amended.  The  additional  securities are to be
issued pursuant to an amendment to the Plan approved by the  Registrant's  Board
of Directors on September 10, 1997 and on July 28, 1998, and by the Registrant's
Shareholders  on September  10, 1998.  Portions of  Registration  Statement  No.
33-94400, 33-56454 and 33-42156 are incorporated herein by reference.

Item 8.  Exhibits.

Exhibit Number          Exhibit
--------------          -------
    4.1*                Bioject Medical Technologies, Inc. 1992 Stock Incentive
                        Plan, as amended

    5.1                 Opinion of Dorsey & Whitney LLP

   23.1                 Consent of Dorsey & Whitney LLP
                        (included in Exhibit 5.1)

   23.2                 Consent of Independent Public Accountants

   24.1                 Power of Attorney (See page II-6 of this Registration
                        Statement)
--------------------

*    Incorporated by reference to Exhibit 4.3 of the Company's Form 10-Q for the
     period ended December 31, 1997.

                                       2
SIGNATURES

     Pursuant to the  requirements of the Securities Act of 1933, the registrant
certifies  that it has  reasonable  grounds to believe  that it meets all of the
requirements  for  filing  on Form S-8 and has  duly  caused  this  registration
statement  to be  signed  on its  behalf  by  the  undersigned,  thereunto  duly
authorized, in the City of Portland, Oregon, on this 26th day of August, 1999.

                                    BIOJECT MEDICAL TECHNOLOGIES INC.

                                    By: /s/ James C. O'Shea
                                        ----------------------------------------
                                        James C. O'Shea
                                        Chairman of the Board, Chief Executive
                                          Officer and President

                                POWER OF ATTORNEY

     Each person whose signature appears below constitutes and appoints James C.
O'Shea and Michael A. Temple, or either of them, his attorney-in-fact,  with the
power  of  substitution,  for  them  in any  and all  capacities,  to  sign  any
amendments to this registration  statement,  and to file the same, with exhibits
thereto and other  documents in connection  therewith,  with the  Securities and
Exchange   Commission,   hereby   ratifying   and   confirming   all  that  said
attorneys-in-fact,  or their  substitute or  substitutes,  may do or cause to be
done by virtue hereof.

     Pursuant  to  the   requirements  of  the  Securities  Act  of  1933,  this
registration  statement  has  been  signed  by  the  following  persons  in  the
capacities and on the date indicated.

Signature                    Title                            Date
---------                    -----                            ----

/s/ James C. O'Shea          Chairman of the Board            May 25, 2000
-----------------------      Chief Executive Officer
James C. O'Shea              and President (Principal
                             Executive, Accounting and
                             Financial Officer)

/s/ William A. Gouveia       Director                         May 31, 2000
-----------------------
William A. Gouveia

/s/ John Ruedy, M.D.         Director                         May 26, 2000
-----------------------
John Ruedy, M.D.

                             Director
-----------------------
Grace Keeney Fey

/s/ Eric T. Herfindal        Director                         May 30, 2000
-----------------------
Eric T. Herfindal

/s/ Richard J. Plestina      Director                         May 27, 2000
-----------------------
Richard J. Plestina

                             Director
-----------------------
David H. de Weese

/s/ Edward Flynn             Director                         May 31, 2000
-----------------------
Edward Flynn

                                       3
EXHIBIT INDEX

Exhibit
Number           Exhibit                                               Page
------           -------                                               ----

 4.1*            Bioject Medical Technologies, Inc.
                 1992 Stock Option Plan

 5.1             Opinion of Dorsey & Whitney LLP

23.1             Consent of Dorsey & Whitney LLP
                 (included in Exhibit 5.1)

23.2             Consent of Independent Public Accountants

24.1             Power of Attorney (See page II-6 of
                 this Registration Statement)
--------------------

*    Incorporated by reference to Exhibit 4.3 of the Company's Form 10-Q for the
     period ended December 31, 1997.