<PAGE>

      As filed with the Securities and Exchange Commission on June 14, 2002
                                     REGISTRATION STATEMENT NO. 333-______

================================================================================

                       SECURITIES AND EXCHANGE COMMISSION
                             WASHINGTON, D.C. 20549
                                    FORM S-8
                             REGISTRATION STATEMENT
                                      UNDER
                           THE SECURITIES ACT OF 1933

                       INVERNESS MEDICAL INNOVATIONS, INC.
             (EXACT NAME OF REGISTRANT AS SPECIFIED IN ITS CHARTER)

<TABLE>
<S>                       <C>                               <C>
                             51 Sawyer Road, Suite 200          04-3565120
      Delaware            Waltham, Massachusetts 021453     (I.R.S. EMPLOYER
(STATE OF INCORPORATION)           (781) 647-3900           IDENTIFICATION NO.)
</TABLE>

              (ADDRESS OF REGISTRANT'S PRINCIPAL EXECUTIVE OFFICES)

    INVERNESS MEDICAL INNOVATIONS, INC. 2001 STOCK OPTION AND INCENTIVE PLAN
                            (FULL TITLE OF THE PLAN)

                                  Ron Zwanziger
                 Chairman, President and Chief Executive Officer
                       Inverness Medical Innovations, Inc.
                            51 Sawyer Road, Suite 200
                          Waltham, Massachusetts 02453
                                 (781) 647-3900

            (NAME, ADDRESS, INCLUDING ZIP CODE, AND TELEPHONE NUMBER,
              INCLUDING AREA CODE, OF AGENT FOR SERVICE)

                                    With copy
                                       to:
                              Scott F. Duggan, Esq.
                               Goodwin Procter LLP
                                 Exchange Place
                        Boston, Massachusetts 02109-2881
                                 (617) 570-1000

                         CALCULATION OF REGISTRATION FEE
<TABLE>
<CAPTION>
======================================================================================================================
  Title of Securities         Amounts to be         Proposed Maximum       Proposed Maximum           Amount of
    Being Registered         Registered (1)        Offering Price Per     Aggregate Offering      Registration Fee
                                                       Share (2)               Price (2)
----------------------------------------------------------------------------------------------------------------------
<S>                         <C>                          <C>                  <C>                     <C>
Common Stock, par value     1,000,000 shares             $17.82               $17,820,000             $1,639.44
    $.001 per share
======================================================================================================================
</TABLE>

(1) This registration statement also relates to such indeterminate number of
    additional shares of the registrant's Common Stock as may be required
    pursuant to the Inverness Medical Innovations, Inc. 2001 Stock Option and
    Incentive Plan, as amended, in the event of a stock dividend, stock split,
    split-up, recapitalization, forfeiture of stock under the plan or other
    similar event.
(2) This estimate is made pursuant to Rule 457(c) and (h) under the Securities
    Act of 1933, as amended, solely for the purposes of determining the amount
    of the registration fee. The registration fee is based on the average of the
    high and low prices for the registrant's Common Stock as reported on The
    American Stock Exchange on June 12, 2002.
===============================================================================

<PAGE>

         This Registration Statement on Form S-8 is being filed by Inverness
Medical Innovations, Inc. (the "Company") for the purpose of registering an
additional 1,000,000 shares of common stock, par value $.001 per share, to be
issued pursuant to the Inverness Medical Innovations, Inc. 2001 Stock Option and
Incentive Plan, as amended (the "Plan"). The contents of the Company's
Registration Statement on Form S-8 (Registration No. 333-74032) relating to the
Plan are incorporated by reference into this Registration Statement in
accordance with General Instruction E to Form S-8.

ITEM 8. EXHIBITS.

<TABLE>
<CAPTION>
    EXHIBIT NO.           DESCRIPTION
    <S>              <C>  <C>
       4.1           --   Amended and Restated Certificate of Incorporation of the Company (incorporated by
                          reference to Exhibit 3.1 to the Company's Form 10-K, as amended, for the year ended
                          December 31, 2001, File No. 001-16789)
       4.2           --   Certificate of Designation, Preferences and Rights of Series A Convertible Preferred
                          Stock of the Company (incorporated by reference to Exhibit 99.2 to the Company's
                          Current Report on Form 8-K dated December 20, 2001, File No. 001-16789)
       4.3           --   Amended and Restated By-laws of the Company (incorporated by reference to Exhibit 3.3
                          to the Company's Form 10-K, as amended, for the year ended December 31, 2001, File
                          No. 001-16789)
       4.4           --   Inverness Medical Innovations, Inc. 2001 Stock Option and Incentive Plan (incorporated
                          by reference to Exhibit 10.1 to the Company's Registration Statement on Form S-4, as
                          amended (File No. 333-67392))
      *4.5           --   Amendment No. 1 to Inverness Medical Innovations, Inc. 2001 Stock Option and Incentive
                          Plan
      *5.1           --   Opinion of Goodwin Procter LLP
     *23.1           --   Consent of Arthur Andersen LLP
     *23.2           --   Consent of Arthur Andersen LLP
     *23.3           --   Consent of Amper Politziner & Mattia P.A.
      23.4           --   Consent of Goodwin Procter LLP (included in Exhibit 5.1)
      24.1           --   Power of Attorney (contained in signature page)
</TABLE>

-----------
*        Filed herewith.

<PAGE>

                                   SIGNATURES

         Pursuant to the requirements of the Securities Act of 1933, the
registrant certifies that it has reasonable grounds to believe that it meets all
of the requirements for filing on Form S-8 and has duly caused this registration
statement to be signed on its behalf by the undersigned, thereunto duly
authorized, in the City of Waltham, The Commonwealth of Massachusetts, on June
14, 2002.

                            INVERNESS MEDICAL INNOVATIONS, INC.

                            By: /s/ Ron Zwanziger
                                ------------------------------------
                                Ron Zwanziger
                                Chairman, President and Chief Executive Officer

                                POWER OF ATTORNEY

         KNOW ALL BY THESE PRESENTS that each individual whose signature appears
below constitutes and appoints each of Ron Zwanziger and Duane L. James as such
person's true and lawful attorney-in-fact and agent with full power of
substitution and resubstitution, for such person in such person's name, place
and stead, in any and all capacities, to sign any and all amendments (including
post-effective amendments) to this registration statement (or any registration
statement for the same offering that is to be effective upon filing pursuant to
Rule 462(b) under the Securities Act of 1933), and to file the same, with all
exhibits thereto, and all documents in connection therewith, with the Securities
and Exchange Commission, granting unto each said attorney-in-fact and agent full
power and authority to do and perform each and every act and thing requisite and
necessary to be done in and about the premises, as fully to all intents and
purposes as such person might or could do in person, hereby ratifying and
confirming all that any said attorney-in-fact and agent, or any substitute or
substitutes of any of them, may lawfully do or cause to be done by virtue
hereof.

         Pursuant to the requirements of the Securities Act of 1933, this
Registration Statement has been signed by the following persons in the
capacities and on the dates indicated.

<TABLE>
<CAPTION>
               SIGNATURE                                 TITLE                                  DATE
<S>                                      <C>                                                <C>
/s/ Ron Zwanziger                        Chairman, President and Chief                      June 14, 2002
------------------------------------     Executive Officer (Principal
Ron Zwanziger                            Executive Officer)

/s/ Duane L. James                       Vice President of Finance and                      June 14, 2002
------------------------------------     Treasurer (Principal Financial
Duane L. James                           Officer and Principal Accounting
                                         Officer)

/s/ David Scott                          Director                                           June 14, 2002
--------------------------------------
David Scott, Ph.D.

/s/ Ernest A. Carabillo                  Director                                           June 13, 2002
------------------------------------
Ernest A. Carabillo, Jr.

/s/ Carol R. Goldberg                    Director                                           June 14, 2002
------------------------------------
Carol R. Goldberg

/s/ Robert P. Khederian                  Director                                           June 14, 2002
------------------------------------
Robert P. Khederian

/s/ John F. Levy                         Director                                           June 12, 2002
------------------------------------

John F. Levy

/s/ Peter Townsend                       Director                                           June 14, 2002
--------------------------------------
Peter Townsend

/s/ Alfred M. Zeien                      Director                                           June 12, 2002
--------------------------------------
Alfred M. Zeien
</TABLE>

<PAGE>

                                                EXHIBIT INDEX

<TABLE>
<CAPTION>
    EXHIBIT NO.           DESCRIPTION
    <S>              <C>  <C>
       4.1           --   Amended and Restated Certificate of Incorporation of the Company (incorporated by
                          reference to Exhibit 3.1 to the Company's Form 10-K, as amended, for the year ended
                          December 31, 2001, File No. 001-16789)
       4.2           --   Certificate of Designation, Preferences and Rights of Series A Convertible Preferred
                          Stock of the Company (incorporated by reference to Exhibit 99.2 to the Company's
                          Current Report on Form 8-K dated December 20, 2001, File No. 001-16789)
       4.3           --   Amended and Restated By-laws of the Company (incorporated by reference to Exhibit 3.3
                          to the Company's Form 10-K, as amended, for the year ended December 31, 2001, File
                          No. 001-16789)
       4.4           --   Inverness Medical Innovations, Inc. 2001 Stock Option and Incentive Plan (incorporated
                          by reference to Exhibit 10.1 to the Company's Registration Statement on Form S-4, as
                          amended (File No. 333-67392))
      *4.5           --   Amendment No. 1 to Inverness Medical Innovations, Inc. 2001 Stock Option and Incentive
                          Plan
      *5.1           --   Opinion of Goodwin Procter LLP
     *23.1           --   Consent of Arthur Andersen LLP
     *23.2           --   Consent of Arthur Andersen LLP
     *23.3           --   Consent of Amper Politziner & Mattia P.A.
      23.4           --   Consent of Goodwin Procter LLP (included in Exhibit 5.1)
      24.1           --   Power of Attorney (contained in signature page)
</TABLE>
[{"type": "S-8", "sequence": "1", "filename": "a2082436zs-8.txt", "description": "FORM S-8", "secsgml_size_bytes": 12195}]
{"company-data": {"conformed-name": "INVERNESS MEDICAL INNOVATIONS INC", "cik": "0001145460", "assigned-sic": "2835", "irs-number": "043565120", "state-of-incorporation": "DE", "fiscal-year-end": "1231"}, "filing-values": {"form-type": "S-8", "act": "33", "file-number": "333-90530", "film-number": "02679401"}, "business-address": {"street1": "51 SAWYER ROAD", "street2": "SUITE 200", "city": "WALTHAM", "state": "MA", "zip": "02453", "phone": "7816473900"}, "mail-address": {"street1": "51 SAWYER ROAD", "street2": "SUITE 200", "city": "WALTHAM", "state": "MA", "zip": "02453"}}
As filed with the Securities and Exchange Commission on June 14, 2002
                                     REGISTRATION STATEMENT NO. 333-______

================================================================================

                       SECURITIES AND EXCHANGE COMMISSION
                             WASHINGTON, D.C. 20549
                                    FORM S-8
                             REGISTRATION STATEMENT
                                      UNDER
                           THE SECURITIES ACT OF 1933

                       INVERNESS MEDICAL INNOVATIONS, INC.
             (EXACT NAME OF REGISTRANT AS SPECIFIED IN ITS CHARTER)
51 Sawyer Road, Suite 200          04-3565120
      Delaware            Waltham, Massachusetts 021453     (I.R.S. EMPLOYER
(STATE OF INCORPORATION)           (781) 647-3900           IDENTIFICATION NO.)
(ADDRESS OF REGISTRANT'S PRINCIPAL EXECUTIVE OFFICES)

    INVERNESS MEDICAL INNOVATIONS, INC. 2001 STOCK OPTION AND INCENTIVE PLAN
                            (FULL TITLE OF THE PLAN)

                                  Ron Zwanziger
                 Chairman, President and Chief Executive Officer
                       Inverness Medical Innovations, Inc.
                            51 Sawyer Road, Suite 200
                          Waltham, Massachusetts 02453
                                 (781) 647-3900

            (NAME, ADDRESS, INCLUDING ZIP CODE, AND TELEPHONE NUMBER,
              INCLUDING AREA CODE, OF AGENT FOR SERVICE)

                                    With copy
                                       to:
                              Scott F. Duggan, Esq.
                               Goodwin Procter LLP
                                 Exchange Place
                        Boston, Massachusetts 02109-2881
                                 (617) 570-1000

                         CALCULATION OF REGISTRATION FEE
======================================================================================================================
  Title of Securities         Amounts to be         Proposed Maximum       Proposed Maximum           Amount of
    Being Registered         Registered (1)        Offering Price Per     Aggregate Offering      Registration Fee
                                                       Share (2)               Price (2)
----------------------------------------------------------------------------------------------------------------------
Common Stock, par value     1,000,000 shares             $17.82               $17,820,000             $1,639.44
    $.001 per share
======================================================================================================================
(1) This registration statement also relates to such indeterminate number of
    additional shares of the registrant's Common Stock as may be required
    pursuant to the Inverness Medical Innovations, Inc. 2001 Stock Option and
    Incentive Plan, as amended, in the event of a stock dividend, stock split,
    split-up, recapitalization, forfeiture of stock under the plan or other
    similar event.
(2) This estimate is made pursuant to Rule 457(c) and (h) under the Securities
    Act of 1933, as amended, solely for the purposes of determining the amount
    of the registration fee. The registration fee is based on the average of the
    high and low prices for the registrant's Common Stock as reported on The
    American Stock Exchange on June 12, 2002.
===============================================================================
This Registration Statement on Form S-8 is being filed by Inverness
Medical Innovations, Inc. (the "Company") for the purpose of registering an
additional 1,000,000 shares of common stock, par value $.001 per share, to be
issued pursuant to the Inverness Medical Innovations, Inc. 2001 Stock Option and
Incentive Plan, as amended (the "Plan"). The contents of the Company's
Registration Statement on Form S-8 (Registration No. 333-74032) relating to the
Plan are incorporated by reference into this Registration Statement in
accordance with General Instruction E to Form S-8.

ITEM 8. EXHIBITS.
EXHIBIT NO.           DESCRIPTION
4.1           --   Amended and Restated Certificate of Incorporation of the Company (incorporated by
                          reference to Exhibit 3.1 to the Company's Form 10-K, as amended, for the year ended
                          December 31, 2001, File No. 001-16789)
       4.2           --   Certificate of Designation, Preferences and Rights of Series A Convertible Preferred
                          Stock of the Company (incorporated by reference to Exhibit 99.2 to the Company's
                          Current Report on Form 8-K dated December 20, 2001, File No. 001-16789)
       4.3           --   Amended and Restated By-laws of the Company (incorporated by reference to Exhibit 3.3
                          to the Company's Form 10-K, as amended, for the year ended December 31, 2001, File
                          No. 001-16789)
       4.4           --   Inverness Medical Innovations, Inc. 2001 Stock Option and Incentive Plan (incorporated
                          by reference to Exhibit 10.1 to the Company's Registration Statement on Form S-4, as
                          amended (File No. 333-67392))
      *4.5           --   Amendment No. 1 to Inverness Medical Innovations, Inc. 2001 Stock Option and Incentive
                          Plan
      *5.1           --   Opinion of Goodwin Procter LLP
     *23.1           --   Consent of Arthur Andersen LLP
     *23.2           --   Consent of Arthur Andersen LLP
     *23.3           --   Consent of Amper Politziner & Mattia P.A.
      23.4           --   Consent of Goodwin Procter LLP (included in Exhibit 5.1)
      24.1           --   Power of Attorney (contained in signature page)
-----------
*        Filed herewith.
SIGNATURES

         Pursuant to the requirements of the Securities Act of 1933, the
registrant certifies that it has reasonable grounds to believe that it meets all
of the requirements for filing on Form S-8 and has duly caused this registration
statement to be signed on its behalf by the undersigned, thereunto duly
authorized, in the City of Waltham, The Commonwealth of Massachusetts, on June
14, 2002.

                            INVERNESS MEDICAL INNOVATIONS, INC.

                            By: /s/ Ron Zwanziger
                                ------------------------------------
                                Ron Zwanziger
                                Chairman, President and Chief Executive Officer

                                POWER OF ATTORNEY

         KNOW ALL BY THESE PRESENTS that each individual whose signature appears
below constitutes and appoints each of Ron Zwanziger and Duane L. James as such
person's true and lawful attorney-in-fact and agent with full power of
substitution and resubstitution, for such person in such person's name, place
and stead, in any and all capacities, to sign any and all amendments (including
post-effective amendments) to this registration statement (or any registration
statement for the same offering that is to be effective upon filing pursuant to
Rule 462(b) under the Securities Act of 1933), and to file the same, with all
exhibits thereto, and all documents in connection therewith, with the Securities
and Exchange Commission, granting unto each said attorney-in-fact and agent full
power and authority to do and perform each and every act and thing requisite and
necessary to be done in and about the premises, as fully to all intents and
purposes as such person might or could do in person, hereby ratifying and
confirming all that any said attorney-in-fact and agent, or any substitute or
substitutes of any of them, may lawfully do or cause to be done by virtue
hereof.

         Pursuant to the requirements of the Securities Act of 1933, this
Registration Statement has been signed by the following persons in the
capacities and on the dates indicated.
SIGNATURE                                 TITLE                                  DATE
/s/ Ron Zwanziger                        Chairman, President and Chief                      June 14, 2002
------------------------------------     Executive Officer (Principal
Ron Zwanziger                            Executive Officer)

/s/ Duane L. James                       Vice President of Finance and                      June 14, 2002
------------------------------------     Treasurer (Principal Financial
Duane L. James                           Officer and Principal Accounting
                                         Officer)

/s/ David Scott                          Director                                           June 14, 2002
--------------------------------------
David Scott, Ph.D.

/s/ Ernest A. Carabillo                  Director                                           June 13, 2002
------------------------------------
Ernest A. Carabillo, Jr.

/s/ Carol R. Goldberg                    Director                                           June 14, 2002
------------------------------------
Carol R. Goldberg

/s/ Robert P. Khederian                  Director                                           June 14, 2002
------------------------------------
Robert P. Khederian

/s/ John F. Levy                         Director                                           June 12, 2002
------------------------------------

John F. Levy

/s/ Peter Townsend                       Director                                           June 14, 2002
--------------------------------------
Peter Townsend

/s/ Alfred M. Zeien                      Director                                           June 12, 2002
--------------------------------------
Alfred M. Zeien
EXHIBIT INDEX
EXHIBIT NO.           DESCRIPTION
4.1           --   Amended and Restated Certificate of Incorporation of the Company (incorporated by
                          reference to Exhibit 3.1 to the Company's Form 10-K, as amended, for the year ended
                          December 31, 2001, File No. 001-16789)
       4.2           --   Certificate of Designation, Preferences and Rights of Series A Convertible Preferred
                          Stock of the Company (incorporated by reference to Exhibit 99.2 to the Company's
                          Current Report on Form 8-K dated December 20, 2001, File No. 001-16789)
       4.3           --   Amended and Restated By-laws of the Company (incorporated by reference to Exhibit 3.3
                          to the Company's Form 10-K, as amended, for the year ended December 31, 2001, File
                          No. 001-16789)
       4.4           --   Inverness Medical Innovations, Inc. 2001 Stock Option and Incentive Plan (incorporated
                          by reference to Exhibit 10.1 to the Company's Registration Statement on Form S-4, as
                          amended (File No. 333-67392))
      *4.5           --   Amendment No. 1 to Inverness Medical Innovations, Inc. 2001 Stock Option and Incentive
                          Plan
      *5.1           --   Opinion of Goodwin Procter LLP
     *23.1           --   Consent of Arthur Andersen LLP
     *23.2           --   Consent of Arthur Andersen LLP
     *23.3           --   Consent of Amper Politziner & Mattia P.A.
      23.4           --   Consent of Goodwin Procter LLP (included in Exhibit 5.1)
      24.1           --   Power of Attorney (contained in signature page)