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<p align="center" style="margin:0in 0in .0001pt;text-align:center;text-indent:0in;"><b><font size="2" face="Times New Roman" style="font-size:10.0pt;font-weight:bold;letter-spacing:-.1pt;">As filed with the Securities and Exchange Commission on June
5, 2002</font></b></p>

<p align="right" style="margin:0in .5in .0001pt 0in;text-align:right;text-indent:0in;"><b><font size="2" face="Times New Roman" style="font-size:10.0pt;font-weight:bold;letter-spacing:-.1pt;">Registration No. 333-</font></b></p>

<p align="left" style="margin:0in 0in .0001pt;text-align:left;text-indent:.5in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;letter-spacing:-.1pt;">&nbsp;</font></p>

<div style="border:none;border-top:double windowtext 9.0pt;padding:0in 0in 0in 0in;">

<p align="left" style="border:none;margin:0in 0in .0001pt;padding:0in;text-align:left;text-indent:.5in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>

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<p align="center" style="margin:0in 0in .0001pt;text-align:center;text-indent:0in;"><b><font size="5" face="Times New Roman" style="font-size:16.0pt;font-weight:bold;letter-spacing:-.2pt;">SECURITIES AND
EXCHANGE COMMISSION</font></b></p>

<p align="center" style="margin:0in 0in .0001pt;text-align:center;text-indent:0in;"><b><font size="2" face="Times New Roman" style="font-size:10.0pt;font-weight:bold;letter-spacing:-.1pt;">Washington, D.C. 20549</font></b></p>

<p align="center" style="margin:0in 0in .0001pt;text-align:center;text-indent:0in;"><b><font size="2" face="Times New Roman" style="font-size:10.0pt;font-weight:bold;letter-spacing:-.1pt;">&nbsp;</font></b></p>


<div align="center" style="margin:0in 0in .0001pt;text-align:center;text-indent:0in;"><b><font size="2" face="Times New Roman" style="font-size:10.0pt;font-weight:bold;letter-spacing:-.1pt;">

<hr size="1" width="25%" noshade color="black" align="center">

</font></b></div>


<p align="center" style="margin:0in 0in .0001pt;text-align:center;text-indent:0in;"><b><font size="2" face="Times New Roman" style="font-size:10.0pt;font-weight:bold;letter-spacing:-.1pt;">&nbsp;</font></b></p>

<p align="center" style="margin:0in 0in .0001pt;text-align:center;text-indent:0in;"><b><font size="5" face="Times New Roman" style="font-size:16.0pt;font-weight:bold;letter-spacing:-.2pt;">FORM S-8</font></b></p>

<p align="center" style="margin:0in 0in .0001pt;text-align:center;text-indent:0in;"><b><font size="5" face="Times New Roman" style="font-size:16.0pt;font-weight:bold;letter-spacing:-.15pt;">REGISTRATION
STATEMENT</font></b></p>

<p align="center" style="margin:0in 0in .0001pt;text-align:center;text-indent:0in;"><b><i><font size="3" face="Times New Roman" style="font-size:12.0pt;font-style:italic;font-weight:bold;letter-spacing:-.1pt;">Under</font></i></b></p>

<p align="center" style="margin:0in 0in .0001pt;text-align:center;text-indent:0in;"><b><i><font size="3" face="Times New Roman" style="font-size:12.0pt;font-style:italic;font-weight:bold;letter-spacing:-.1pt;">The
Securities Act of 1933</font></i></b></p>


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<table border="0" cellspacing="0" cellpadding="0" width="100%" style="border-collapse:collapse;width:100.0%;">
 <tr>
  <td width="100%" valign="top" style="padding:0in .7pt 0in .7pt;width:100.0%;">
  <p align="center" style="font-size:12.0pt;margin:0in 0in .0001pt;text-align:center;text-indent:0in;">&nbsp;</p>
  </td>
 </tr>
 <tr>
  <td width="100%" valign="top" style="padding:0in .7pt 0in .7pt;width:100.0%;">
  <p align="center" style="margin:0in 0in .0001pt;text-align:center;text-indent:0in;"><b><font size="5" face="Times New Roman" style="font-size:16.0pt;font-weight:bold;letter-spacing:-.2pt;">CIPHERGEN BIOSYSTEMS, INC.</font></b></p>
  </td>
 </tr>
 <tr>
  <td width="100%" valign="top" style="padding:0in .7pt 0in .7pt;width:100.0%;">
  <p align="center" style="margin:0in 0in .0001pt;text-align:center;text-indent:0in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;letter-spacing:-.1pt;">(Exact
  name of Registrant as specified in its charter)</font></p>
  </td>
 </tr>
 <tr>
  <td width="100%" valign="top" style="padding:0in .7pt 0in .7pt;width:100.0%;">
  <p align="center" style="font-size:12.0pt;margin:0in 0in .0001pt;text-align:center;text-indent:0in;">&nbsp;</p>
  </td>
 </tr>
</table>

</div>


<div align="center" style="margin:0in 0in .0001pt;text-align:center;text-indent:0in;"><font size="3" face="Times New Roman" style="font-size:12.0pt;">

<hr size="1" width="25%" noshade color="black" align="center">

</font></div>


<p align="left" style="margin:0in 0in .0001pt;text-align:left;text-indent:0in;"><font size="3" face="Times New Roman" style="font-size:12.0pt;">&nbsp;</font></p>

<div align="center">

<table border="0" cellspacing="0" cellpadding="0" width="100%" style="border-collapse:collapse;width:100.0%;">
 <tr>
  <td width="48%" valign="top" style="padding:0in .7pt 0in .7pt;width:48.6%;">
  <p align="center" style="margin:0in 0in .0001pt;text-align:center;text-indent:0in;"><b><font size="2" face="Times New Roman" style="font-size:10.0pt;font-weight:bold;letter-spacing:-.1pt;">Delaware</font></b></p>
  </td>
  <td width="2%" valign="bottom" style="padding:0in .7pt 0in .7pt;width:2.7%;">
  <p align="left" style="font-size:1.0pt;margin:0in 0in .0001pt;text-align:left;text-indent:0in;">&nbsp;</p>
  </td>
  <td width="48%" valign="top" style="padding:0in .7pt 0in .7pt;width:48.68%;">
  <p align="center" style="margin:0in 0in .0001pt;text-align:center;text-indent:0in;"><b><font size="2" face="Times New Roman" style="font-size:10.0pt;font-weight:bold;letter-spacing:-.1pt;">33-059-5156</font></b></p>
  </td>
 </tr>
 <tr>
  <td width="48%" valign="top" style="padding:0in .7pt 0in .7pt;width:48.6%;">
  <p align="center" style="margin:0in 0in .0001pt;text-align:center;text-indent:0in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;letter-spacing:-.1pt;">(State
  or other jurisdiction of</font><font size="2" style="font-size:10.0pt;">  <font style="letter-spacing:-.1pt;">incorporation
  or organization)</font></font></p>
  </td>
  <td width="2%" valign="bottom" style="padding:0in .7pt 0in .7pt;width:2.7%;">
  <p align="left" style="font-size:1.0pt;margin:0in 0in .0001pt;text-align:left;text-indent:0in;">&nbsp;</p>
  </td>
  <td width="48%" valign="top" style="padding:0in .7pt 0in .7pt;width:48.68%;">
  <p align="center" style="margin:0in 0in .0001pt;text-align:center;text-indent:0in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;letter-spacing:-.1pt;">(I.R.S.
  Employer</font><font size="2" style="font-size:10.0pt;">  <font style="letter-spacing:-.1pt;">Identification Number)</font></font></p>
  </td>
 </tr>
 <tr>
  <td width="48%" valign="top" style="padding:0in .7pt 0in .7pt;width:48.6%;">
  <p align="center" style="font-size:12.0pt;margin:0in 0in .0001pt;text-align:center;text-indent:0in;">&nbsp;</p>
  </td>
  <td width="2%" valign="bottom" style="padding:0in .7pt 0in .7pt;width:2.7%;">
  <p align="left" style="font-size:12.0pt;margin:0in 0in .0001pt;text-align:left;text-indent:0in;">&nbsp;</p>
  </td>
  <td width="48%" valign="top" style="padding:0in .7pt 0in .7pt;width:48.68%;">
  <p align="center" style="font-size:12.0pt;margin:0in 0in .0001pt;text-align:center;text-indent:0in;">&nbsp;</p>
  </td>
 </tr>
</table>

</div>

<p align="center" style="margin:12.0pt 0in .0001pt;text-align:center;text-indent:0in;"><b><font size="2" face="Times New Roman" style="font-size:10.0pt;font-weight:bold;letter-spacing:-.1pt;">6611 Dumbarton
Circle</font></b><font size="2" style="font-size:10.0pt;">  <br>
<b><font style="font-weight:bold;letter-spacing:-.1pt;">Fremont, CA 94555</font></b><br>
<b><font style="font-weight:bold;letter-spacing:-.1pt;">(510) 505-2100</font></b></font></p>

<p align="center" style="margin:0in 0in .0001pt;text-align:center;text-indent:0in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;letter-spacing:-.1pt;">(Address, including zip
code, and telephone number, including area code, of Registrant&#146;s principal
executive offices)</font></p>

<p align="center" style="margin:0in 0in .0001pt;text-align:center;text-indent:0in;"><font size="3" face="Times New Roman" style="font-size:12.0pt;">&nbsp;</font></p>

<p align="center" style="margin:0in 0in .0001pt;text-align:center;text-indent:0in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>

<p align="center" style="margin:0in 0in .0001pt;text-align:center;text-indent:0in;"><b><font size="2" face="Times New Roman" style="font-size:10.0pt;font-weight:bold;letter-spacing:-.1pt;">2000 STOCK PLAN<br>
2000 EMPLOYEE STOCK PURCHASE PLAN</font></b></p>

<p align="center" style="margin:0in 0in .0001pt;text-align:center;text-indent:0in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;letter-spacing:-.1pt;">(Full title of the Plans)</font></p>

<p align="center" style="margin:0in 0in .0001pt;text-align:center;text-indent:0in;"><font size="3" face="Times New Roman" style="font-size:12.0pt;">&nbsp;</font></p>


<div align="center" style="margin:0in 0in .0001pt;text-align:center;text-indent:0in;"><font size="3" face="Times New Roman" style="font-size:12.0pt;">

<hr size="1" width="25%" noshade color="black" align="center">

</font></div>


<p align="center" style="margin:0in 0in .0001pt;text-align:center;text-indent:0in;"><font size="3" face="Times New Roman" style="font-size:12.0pt;">&nbsp;</font></p>

<p align="center" style="margin:0in 0in .0001pt;text-align:center;text-indent:0in;"><b><font size="2" face="Times New Roman" style="font-size:10.0pt;font-weight:bold;letter-spacing:-.1pt;">William E. Rich</font></b></p>

<p align="center" style="margin:0in 0in .0001pt;text-align:center;text-indent:0in;"><b><font size="2" face="Times New Roman" style="font-size:10.0pt;font-weight:bold;letter-spacing:-.1pt;">President and Chief Executive Officer</font></b></p>

<p align="center" style="margin:0in 0in .0001pt;text-align:center;text-indent:0in;"><b><font size="2" face="Times New Roman" style="font-size:10.0pt;font-weight:bold;letter-spacing:-.1pt;">Ciphergen Biosystems, Inc.</font></b></p>

<p align="center" style="margin:0in 0in .0001pt;text-align:center;text-indent:0in;"><b><font size="2" face="Times New Roman" style="font-size:10.0pt;font-weight:bold;letter-spacing:-.1pt;">6611 Dumbarton Circle</font></b></p>

<p align="center" style="margin:0in 0in .0001pt;text-align:center;text-indent:0in;"><b><font size="2" face="Times New Roman" style="font-size:10.0pt;font-weight:bold;letter-spacing:-.1pt;">Fremont, CA 94555</font></b></p>

<p align="center" style="margin:0in 0in .0001pt;text-align:center;text-indent:0in;"><b><font size="2" face="Times New Roman" style="font-size:10.0pt;font-weight:bold;letter-spacing:-.1pt;">(510) 505-2100</font></b></p>

<p align="center" style="margin:0in 0in .0001pt;text-align:center;text-indent:0in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;letter-spacing:-.1pt;">(Name, address,
including zip code, and telephone number, including area code, of agent for
service)</font></p>

<p align="center" style="margin:0in 0in .0001pt;text-align:center;text-indent:0in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;letter-spacing:-.1pt;">&nbsp;</font></p>


<div align="center" style="margin:0in 0in .0001pt;text-align:center;text-indent:0in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;letter-spacing:-.1pt;">

<hr size="1" width="25%" noshade color="black" align="center">

</font></div>


<p align="center" style="margin:0in 0in .0001pt;text-align:center;text-indent:0in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;letter-spacing:-.1pt;">&nbsp;</font></p>

<p align="center" style="margin:0in 0in .0001pt;text-align:center;text-indent:0in;"><i><font size="2" face="Times New Roman" style="font-size:10.0pt;font-style:italic;letter-spacing:-.1pt;">Copies to:</font></i></p>

<p align="center" style="margin:0in 0in .0001pt;text-align:center;text-indent:0in;"><b><font size="2" face="Times New Roman" style="font-size:10.0pt;font-weight:bold;letter-spacing:-.1pt;">Michael J. O&#146;Donnell</font></b></p>

<p align="center" style="margin:0in 0in .0001pt;text-align:center;text-indent:0in;"><b><font size="2" face="Times New Roman" style="font-size:10.0pt;font-weight:bold;letter-spacing:-.1pt;">Wilson Sonsini Goodrich &amp; Rosati</font></b></p>

<p align="center" style="margin:0in 0in .0001pt;text-align:center;text-indent:0in;"><b><font size="2" face="Times New Roman" style="font-size:10.0pt;font-weight:bold;letter-spacing:-.1pt;">Professional Corporation</font></b></p>

<p align="center" style="margin:0in 0in .0001pt;text-align:center;text-indent:0in;"><b><font size="2" face="Times New Roman" style="font-size:10.0pt;font-weight:bold;letter-spacing:-.1pt;">650 Page Mill Road</font></b></p>

<p align="center" style="margin:0in 0in .0001pt;text-align:center;text-indent:0in;"><b><font size="2" face="Times New Roman" style="font-size:10.0pt;font-weight:bold;letter-spacing:-.1pt;">Palo Alto, CA 94304</font></b></p>

<p align="center" style="margin:0in 0in .0001pt;text-align:center;text-indent:0in;"><b><font size="2" face="Times New Roman" style="font-size:10.0pt;font-weight:bold;letter-spacing:-.1pt;">(650) 493-9300</font></b></p>

<p align="center" style="margin:0in 0in .0001pt;text-align:center;text-indent:0in;"><b><font size="2" face="Times New Roman" style="font-size:10.0pt;font-weight:bold;letter-spacing:-.1pt;">&nbsp;</font></b></p>


<div align="center" style="margin:0in 0in .0001pt;text-align:center;text-indent:0in;"><b><font size="2" face="Times New Roman" style="font-size:10.0pt;font-weight:bold;letter-spacing:-.1pt;">

<hr size="1" width="25%" noshade color="black" align="center">

</font></b></div>


<p align="left" style="margin:0in 0in .0001pt;text-align:left;text-indent:.5in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>

<p align="center" style="margin:0in 0in .0001pt;text-align:center;text-indent:0in;"><b><font size="2" face="Times New Roman" style="font-size:10.0pt;font-weight:bold;letter-spacing:-.1pt;">CALCULATION OF
REGISTRATION FEE</font></b></p>

<p align="center" style="margin:0in 0in .0001pt;text-align:center;text-indent:0in;"><b><font size="2" face="Times New Roman" style="font-size:10.0pt;font-weight:bold;letter-spacing:-.1pt;">&nbsp;</font></b></p>

<table border="0" cellspacing="0" cellpadding="0" width="100%" style="border-collapse:collapse;width:100.0%;">
 <tr>
  <td width="35%" valign="bottom" style="border:none;border-bottom:solid windowtext .5pt;padding:0in .7pt 0in .7pt;width:35.62%;">
  <p align="center" style="margin:0in 0in .0001pt 10.0pt;page-break-after:avoid;text-align:center;text-indent:-10.0pt;"><b><font size="1" face="Times New Roman" style="font-size:8.0pt;font-weight:bold;letter-spacing:-.1pt;">Title of Each Class of<br>
  Securities to</font></b><b><font size="1" style="font-size:8.0pt;font-weight:bold;">  <font style="letter-spacing:-.1pt;">be Registered</font></font></b></p>
  </td>
  <td width="1%" valign="bottom" style="padding:0in .7pt 0in .7pt;width:1.12%;">
  <p align="left" style="font-size:1.0pt;margin:0in 0in .0001pt;page-break-after:avoid;text-align:left;text-indent:0in;">&nbsp;</p>
  </td>
  <td width="13%" valign="bottom" style="border:none;border-bottom:solid windowtext .5pt;padding:0in .7pt 0in .7pt;width:13.3%;">
  <p align="center" style="margin:0in 0in .0001pt;page-break-after:avoid;text-align:center;text-indent:0in;"><b><font size="1" face="Times New Roman" style="font-size:8.0pt;font-weight:bold;letter-spacing:-.1pt;">Amount</font></b><b><font size="1" style="font-size:8.0pt;font-weight:bold;">  <font style="letter-spacing:-.1pt;">to be</font><br>
  <font style="letter-spacing:-.1pt;">Registered</font></font></b></p>
  </td>
  <td width="1%" valign="bottom" style="padding:0in .7pt 0in .7pt;width:1.1%;">
  <p align="left" style="font-size:1.0pt;margin:0in 0in .0001pt;page-break-after:avoid;text-align:left;text-indent:0in;">&nbsp;</p>
  </td>
  <td width="16%" colspan="2" valign="bottom" style="border:none;border-bottom:solid windowtext .5pt;padding:0in .7pt 0in .7pt;width:16.64%;">
  <p align="center" style="margin:0in 0in .0001pt;page-break-after:avoid;text-align:center;text-indent:0in;"><b><font size="1" face="Times New Roman" style="font-size:8.0pt;font-weight:bold;letter-spacing:-.1pt;">Proposed</font></b><b><font size="1" style="font-size:8.0pt;font-weight:bold;">  <font style="letter-spacing:-.1pt;">Maximum</font><br>
  <font style="letter-spacing:-.1pt;">Offering</font>  <font style="letter-spacing:-.1pt;">Price</font><br>
  <font style="letter-spacing:-.1pt;">Per Share</font></font></b></p>
  </td>
  <td width="1%" valign="bottom" style="padding:0in .7pt 0in .7pt;width:1.1%;">
  <p align="left" style="font-size:1.0pt;margin:0in 0in .0001pt;page-break-after:avoid;text-align:left;text-indent:0in;">&nbsp;</p>
  </td>
  <td width="15%" colspan="2" valign="bottom" style="border:none;border-bottom:solid windowtext .5pt;padding:0in .7pt 0in .7pt;width:15.52%;">
  <p align="center" style="margin:0in 0in .0001pt;page-break-after:avoid;text-align:center;text-indent:0in;"><b><font size="1" face="Times New Roman" style="font-size:8.0pt;font-weight:bold;letter-spacing:-.1pt;">Proposed</font></b><b><font size="1" style="font-size:8.0pt;font-weight:bold;">  <font style="letter-spacing:-.1pt;">Maximum</font><br>
  <font style="letter-spacing:-.1pt;">Aggregate</font><br>
  <font style="letter-spacing:-.1pt;">Offering Price</font></font></b></p>
  </td>
  <td width="1%" valign="bottom" style="padding:0in .7pt 0in .7pt;width:1.1%;">
  <p align="left" style="font-size:1.0pt;margin:0in 0in .0001pt;page-break-after:avoid;text-align:left;text-indent:0in;">&nbsp;</p>
  </td>
  <td width="13%" colspan="2" valign="bottom" style="border:none;border-bottom:solid windowtext .5pt;padding:0in .7pt 0in .7pt;width:13.32%;">
  <p align="center" style="margin:0in 0in .0001pt;page-break-after:avoid;text-align:center;text-indent:0in;"><b><font size="1" face="Times New Roman" style="font-size:8.0pt;font-weight:bold;letter-spacing:-.1pt;">Amount of</font></b><b><font size="1" style="font-size:8.0pt;font-weight:bold;"><br>
  <font style="letter-spacing:-.1pt;">Registration Fee</font></font></b></p>
  </td>
  <td width="1%" valign="bottom" style="padding:0in .7pt 0in .7pt;width:1.18%;">
  <p align="left" style="font-size:1.0pt;margin:0in 0in .0001pt;page-break-after:avoid;text-align:left;text-indent:0in;">&nbsp;</p>
  </td>
 </tr>
 <tr>
  <td width="35%" valign="bottom" bgcolor="#cceeff" style="background:#CCEEFF;border:none;padding:0in .7pt 0in .7pt;width:35.62%;">
  <p align="left" style="margin:0in 0in .0001pt 10.0pt;page-break-after:avoid;text-align:left;text-indent:-10.0pt;"><font size="2" face="Times New Roman" style="font-size:10.0pt;letter-spacing:-.1pt;">2000
  Stock Plan </font></p>
  <p align="left" style="margin:0in 0in .0001pt 10.0pt;page-break-after:avoid;text-align:left;text-indent:2.0pt;"><font size="2" face="Times New Roman" style="font-size:10.0pt;letter-spacing:-.1pt;">Common
  Stock,&#160; $0.001 par value (1)</font></p>
  </td>
  <td width="1%" valign="bottom" bgcolor="#cceeff" style="background:#CCEEFF;padding:0in .7pt 0in .7pt;width:1.12%;">
  <p align="left" style="font-size:1.0pt;margin:0in 0in .0001pt 10.0pt;page-break-after:avoid;text-align:left;text-indent:-10.0pt;">&nbsp;</p>
  </td>
  <td width="13%" valign="bottom" bgcolor="#cceeff" style="background:#CCEEFF;border:none;padding:0in .7pt 0in .7pt;width:13.3%;">
  <p align="right" style="margin:0in 0in .0001pt 10.0pt;page-break-after:avoid;text-align:right;text-indent:-10.0pt;"><font size="2" face="Times New Roman" style="font-size:10.0pt;letter-spacing:-.1pt;">1,150,000</font></p>
  </td>
  <td width="1%" valign="bottom" bgcolor="#cceeff" style="background:#CCEEFF;padding:0in .7pt 0in .7pt;width:1.1%;">
  <p align="left" style="font-size:1.0pt;margin:0in 0in .0001pt 10.0pt;page-break-after:avoid;text-align:left;text-indent:-10.0pt;">&nbsp;</p>
  </td>
  <td width="4%" valign="bottom" bgcolor="#cceeff" style="background:#CCEEFF;border:none;padding:0in .7pt 0in .7pt;width:4.42%;">
  <p align="left" style="margin:0in 0in .0001pt 10.0pt;page-break-after:avoid;text-align:left;text-indent:-10.0pt;"><font size="2" face="Times New Roman" style="font-size:10.0pt;letter-spacing:-.1pt;">$</font></p>
  </td>
  <td width="12%" valign="bottom" bgcolor="#cceeff" style="background:#CCEEFF;border:none;border-top:solid windowtext .5pt;padding:0in .7pt 0in .7pt;width:12.22%;">
  <p align="right" style="margin:0in 0in .0001pt 10.0pt;page-break-after:avoid;text-align:right;text-indent:-10.0pt;"><font size="2" face="Times New Roman" style="font-size:10.0pt;letter-spacing:-.1pt;">4.83</font></p>
  </td>
  <td width="1%" valign="bottom" bgcolor="#cceeff" style="background:#CCEEFF;padding:0in .7pt 0in .7pt;width:1.1%;">
  <p align="left" style="font-size:1.0pt;margin:0in 0in .0001pt 10.0pt;page-break-after:avoid;text-align:left;text-indent:-10.0pt;">&nbsp;</p>
  </td>
  <td width="4%" valign="bottom" bgcolor="#cceeff" style="background:#CCEEFF;border:none;padding:0in .7pt 0in .7pt;width:4.4%;">
  <p align="left" style="margin:0in 0in .0001pt 10.0pt;page-break-after:avoid;text-align:left;text-indent:-10.0pt;"><font size="2" face="Times New Roman" style="font-size:10.0pt;letter-spacing:-.1pt;">$</font></p>
  </td>
  <td width="11%" valign="bottom" bgcolor="#cceeff" style="background:#CCEEFF;border:none;border-top:solid windowtext .5pt;padding:0in .7pt 0in .7pt;width:11.12%;">
  <p align="right" style="margin:0in 0in .0001pt 10.0pt;page-break-after:avoid;text-align:right;text-indent:-10.0pt;"><font size="2" face="Times New Roman" style="font-size:10.0pt;letter-spacing:-.1pt;">5,554,500</font></p>
  </td>
  <td width="1%" valign="bottom" bgcolor="#cceeff" style="background:#CCEEFF;padding:0in .7pt 0in .7pt;width:1.1%;">
  <p align="left" style="font-size:1.0pt;margin:0in 0in .0001pt 10.0pt;page-break-after:avoid;text-align:left;text-indent:-10.0pt;">&nbsp;</p>
  </td>
  <td width="4%" valign="bottom" bgcolor="#cceeff" style="background:#CCEEFF;border:none;padding:0in .7pt 0in .7pt;width:4.44%;">
  <p align="left" style="margin:0in 0in .0001pt 10.0pt;page-break-after:avoid;text-align:left;text-indent:-10.0pt;"><font size="2" face="Times New Roman" style="font-size:10.0pt;letter-spacing:-.1pt;">$</font></p>
  </td>
  <td width="8%" valign="bottom" bgcolor="#cceeff" style="background:#CCEEFF;border:none;border-top:solid windowtext .5pt;padding:0in .7pt 0in .7pt;width:8.88%;">
  <p align="right" style="margin:0in 0in .0001pt 10.0pt;page-break-after:avoid;text-align:right;text-indent:-10.0pt;"><font size="2" face="Times New Roman" style="font-size:10.0pt;letter-spacing:-.1pt;">511.02</font></p>
  </td>
  <td width="1%" valign="bottom" bgcolor="#cceeff" style="background:#CCEEFF;padding:0in .7pt 0in .7pt;width:1.18%;">
  <p align="left" style="font-size:1.0pt;margin:0in 0in .0001pt 10.0pt;page-break-after:avoid;text-align:left;text-indent:-10.0pt;">&nbsp;</p>
  </td>
 </tr>
 <tr>
  <td width="35%" valign="top" style="padding:0in .7pt 0in .7pt;width:35.62%;">
  <p align="left" style="margin:0in 0in .0001pt 10.0pt;page-break-after:avoid;text-align:left;text-indent:-10.0pt;"><font size="2" face="Times New Roman" style="font-size:10.0pt;letter-spacing:-.1pt;">2000
  Employee Stock Purchase Plan</font></p>
  <p align="left" style="margin:0in 0in .0001pt 10.0pt;page-break-after:avoid;text-align:left;text-indent:2.0pt;"><font size="2" face="Times New Roman" style="font-size:10.0pt;letter-spacing:-.1pt;">Common</font><font size="2" style="font-size:10.0pt;">  <font style="letter-spacing:-.1pt;">Stock,&#160; $0.001 par value</font></font></p>
  <p align="left" style="margin:0in 0in .0001pt 10.0pt;page-break-after:avoid;text-align:left;text-indent:2.0pt;"><font size="2" face="Times New Roman" style="font-size:10.0pt;letter-spacing:-.1pt;">(currently
  outstanding options) (2)</font></p>
  </td>
  <td width="1%" valign="bottom" style="padding:0in .7pt 0in .7pt;width:1.12%;">
  <p align="left" style="font-size:1.0pt;margin:0in 0in .0001pt;page-break-after:avoid;text-align:left;text-indent:0in;">&nbsp;</p>
  </td>
  <td width="13%" valign="bottom" style="padding:0in .7pt 0in .7pt;width:13.3%;">
  <p align="right" style="margin:0in 0in .0001pt;page-break-after:avoid;text-align:right;text-indent:0in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">150,000</font></p>
  </td>
  <td width="1%" valign="bottom" style="padding:0in .7pt 0in .7pt;width:1.1%;">
  <p align="left" style="margin:0in 0in .0001pt;page-break-after:avoid;text-align:left;text-indent:0in;"><font size="2" face="Times New Roman" style="font-size:1.0pt;letter-spacing:-.1pt;">&nbsp;</font></p>
  </td>
  <td width="4%" valign="bottom" style="padding:0in .7pt 0in .7pt;width:4.42%;">
  <p align="left" style="margin:0in 0in .0001pt;page-break-after:avoid;text-align:left;text-indent:0in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;letter-spacing:-.1pt;">$</font></p>
  </td>
  <td width="12%" valign="bottom" style="padding:0in .7pt 0in .7pt;width:12.22%;">
  <p align="right" style="margin:0in 0in .0001pt;page-break-after:avoid;text-align:right;text-indent:0in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;letter-spacing:-.1pt;">4.10</font></p>
  </td>
  <td width="1%" valign="bottom" style="padding:0in .7pt 0in .7pt;width:1.1%;">
  <p align="left" style="margin:0in 0in .0001pt;page-break-after:avoid;text-align:left;text-indent:0in;"><font size="2" face="Times New Roman" style="font-size:1.0pt;letter-spacing:-.1pt;">&nbsp;</font></p>
  </td>
  <td width="4%" valign="bottom" style="padding:0in .7pt 0in .7pt;width:4.4%;">
  <p align="left" style="margin:0in 0in .0001pt;page-break-after:avoid;text-align:left;text-indent:0in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;letter-spacing:-.1pt;">$</font></p>
  </td>
  <td width="11%" valign="bottom" style="padding:0in .7pt 0in .7pt;width:11.12%;">
  <p align="right" style="margin:0in 0in .0001pt;page-break-after:avoid;text-align:right;text-indent:0in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;letter-spacing:-.1pt;">615,000</font></p>
  </td>
  <td width="1%" valign="bottom" style="padding:0in .7pt 0in .7pt;width:1.1%;">
  <p align="left" style="margin:0in 0in .0001pt;page-break-after:avoid;text-align:left;text-indent:0in;"><font size="2" face="Times New Roman" style="font-size:1.0pt;letter-spacing:-.1pt;">&nbsp;</font></p>
  </td>
  <td width="4%" valign="bottom" style="padding:0in .7pt 0in .7pt;width:4.44%;">
  <p align="left" style="margin:0in 0in .0001pt;page-break-after:avoid;text-align:left;text-indent:0in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;letter-spacing:-.1pt;">$</font></p>
  </td>
  <td width="8%" valign="bottom" style="padding:0in .7pt 0in .7pt;width:8.88%;">
  <p align="right" style="margin:0in 0in .0001pt;page-break-after:avoid;text-align:right;text-indent:0in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;letter-spacing:-.1pt;">56.58</font></p>
  </td>
  <td width="1%" valign="bottom" style="padding:0in .7pt 0in .7pt;width:1.18%;">
  <p align="left" style="margin:0in 0in .0001pt;page-break-after:avoid;text-align:left;text-indent:0in;"><font size="2" face="Times New Roman" style="font-size:1.0pt;letter-spacing:-.1pt;">&nbsp;</font></p>
  </td>
 </tr>
 <tr>
  <td width="35%" valign="top" bgcolor="#cceeff" style="background:#CCEEFF;padding:0in .7pt 0in .7pt;width:35.62%;">
  <p align="left" style="font-size:12.0pt;margin:0in 0in .0001pt 10.0pt;page-break-after:avoid;text-align:left;text-indent:-10.0pt;">&nbsp;</p>
  </td>
  <td width="1%" valign="bottom" bgcolor="#cceeff" style="background:#CCEEFF;padding:0in .7pt 0in .7pt;width:1.12%;">
  <p align="left" style="font-size:12.0pt;margin:0in 0in .0001pt;page-break-after:avoid;text-align:left;text-indent:0in;">&nbsp;</p>
  </td>
  <td width="13%" valign="bottom" bgcolor="#cceeff" style="background:#CCEEFF;padding:0in .7pt 0in .7pt;width:13.3%;">
  <p align="right" style="font-size:12.0pt;margin:0in 0in .0001pt;page-break-after:avoid;text-align:right;text-indent:0in;">&nbsp;</p>
  </td>
  <td width="1%" valign="bottom" bgcolor="#cceeff" style="background:#CCEEFF;padding:0in .7pt 0in .7pt;width:1.1%;">
  <p align="left" style="font-size:12.0pt;margin:0in 0in .0001pt;page-break-after:avoid;text-align:left;text-indent:0in;">&nbsp;</p>
  </td>
  <td width="16%" colspan="2" valign="bottom" bgcolor="#cceeff" style="background:#CCEEFF;padding:0in .7pt 0in .7pt;width:16.64%;">
  <p align="right" style="font-size:12.0pt;margin:0in 0in .0001pt;page-break-after:avoid;text-align:right;text-indent:0in;">&nbsp;</p>
  </td>
  <td width="1%" valign="bottom" bgcolor="#cceeff" style="background:#CCEEFF;padding:0in .7pt 0in .7pt;width:1.1%;">
  <p align="left" style="font-size:12.0pt;margin:0in 0in .0001pt;page-break-after:avoid;text-align:left;text-indent:0in;">&nbsp;</p>
  </td>
  <td width="15%" colspan="2" valign="bottom" bgcolor="#cceeff" style="background:#CCEEFF;padding:0in .7pt 0in .7pt;width:15.52%;">
  <p align="right" style="font-size:12.0pt;margin:0in 0in .0001pt;page-break-after:avoid;text-align:right;text-indent:0in;">&nbsp;</p>
  </td>
  <td width="1%" valign="bottom" bgcolor="#cceeff" style="background:#CCEEFF;padding:0in .7pt 0in .7pt;width:1.1%;">
  <p align="left" style="font-size:12.0pt;margin:0in 0in .0001pt;page-break-after:avoid;text-align:left;text-indent:0in;">&nbsp;</p>
  </td>
  <td width="13%" colspan="2" valign="bottom" bgcolor="#cceeff" style="background:#CCEEFF;padding:0in .7pt 0in .7pt;width:13.32%;">
  <p align="right" style="font-size:12.0pt;margin:0in 0in .0001pt;page-break-after:avoid;text-align:right;text-indent:0in;">&nbsp;</p>
  </td>
  <td width="1%" valign="bottom" bgcolor="#cceeff" style="background:#CCEEFF;padding:0in .7pt 0in .7pt;width:1.18%;">
  <p align="left" style="font-size:12.0pt;margin:0in 0in .0001pt;page-break-after:avoid;text-align:left;text-indent:0in;">&nbsp;</p>
  </td>
 </tr>
 <tr>
  <td width="35%" valign="top" style="padding:0in .7pt 0in .7pt;width:35.62%;">
  <p align="left" style="margin:0in 0in .0001pt 10.0pt;page-break-after:avoid;text-align:left;text-indent:-10.0pt;"><b><font size="2" face="Times New Roman" style="font-size:10.0pt;font-weight:bold;letter-spacing:-.1pt;">Total Maximum
  Aggregate Offering Price</font></b></p>
  </td>
  <td width="1%" valign="bottom" style="padding:0in .7pt 0in .7pt;width:1.12%;">
  <p align="left" style="font-size:1.0pt;margin:0in 0in .0001pt;page-break-after:avoid;text-align:left;text-indent:0in;">&nbsp;</p>
  </td>
  <td width="13%" valign="bottom" style="padding:0in .7pt 0in .7pt;width:13.3%;">
  <p align="right" style="font-size:1.0pt;margin:0in 0in .0001pt;page-break-after:avoid;text-align:right;text-indent:0in;">&nbsp;</p>
  </td>
  <td width="1%" valign="bottom" style="padding:0in .7pt 0in .7pt;width:1.1%;">
  <p align="left" style="margin:0in 0in .0001pt;page-break-after:avoid;text-align:left;text-indent:0in;"><b><font size="2" face="Times New Roman" style="font-size:1.0pt;font-weight:bold;letter-spacing:-.1pt;">&nbsp;</font></b></p>
  </td>
  <td width="16%" colspan="2" valign="bottom" style="padding:0in .7pt 0in .7pt;width:16.64%;">
  <p align="right" style="font-size:1.0pt;margin:0in 0in .0001pt;page-break-after:avoid;text-align:right;text-indent:0in;">&nbsp;</p>
  </td>
  <td width="1%" valign="bottom" style="padding:0in .7pt 0in .7pt;width:1.1%;">
  <p align="left" style="margin:0in 0in .0001pt;page-break-after:avoid;text-align:left;text-indent:0in;"><b><font size="2" face="Times New Roman" style="font-size:1.0pt;font-weight:bold;letter-spacing:-.1pt;">&nbsp;</font></b></p>
  </td>
  <td width="4%" valign="bottom" style="padding:0in .7pt 0in .7pt;width:4.4%;">
  <p align="left" style="margin:0in 0in .0001pt;page-break-after:avoid;text-align:left;text-indent:0in;"><b><font size="2" face="Times New Roman" style="font-size:10.0pt;font-weight:bold;letter-spacing:-.1pt;">$</font></b></p>
  </td>
  <td width="11%" valign="bottom" style="padding:0in .7pt 0in .7pt;width:11.12%;">
  <p align="right" style="margin:0in 0in .0001pt;page-break-after:avoid;text-align:right;text-indent:0in;"><b><font size="2" face="Times New Roman" style="font-size:10.0pt;font-weight:bold;letter-spacing:-.1pt;">6,169,500</font></b></p>
  </td>
  <td width="1%" valign="bottom" style="padding:0in .7pt 0in .7pt;width:1.1%;">
  <p align="left" style="margin:0in 0in .0001pt;page-break-after:avoid;text-align:left;text-indent:0in;"><b><font size="2" face="Times New Roman" style="font-size:1.0pt;font-weight:bold;letter-spacing:-.1pt;">&nbsp;</font></b></p>
  </td>
  <td width="13%" colspan="2" valign="bottom" style="padding:0in .7pt 0in .7pt;width:13.32%;">
  <p align="right" style="font-size:1.0pt;margin:0in 0in .0001pt;page-break-after:avoid;text-align:right;text-indent:0in;">&nbsp;</p>
  </td>
  <td width="1%" valign="bottom" style="padding:0in .7pt 0in .7pt;width:1.18%;">
  <p align="left" style="margin:0in 0in .0001pt;page-break-after:avoid;text-align:left;text-indent:0in;"><b><font size="2" face="Times New Roman" style="font-size:1.0pt;font-weight:bold;letter-spacing:-.1pt;">&nbsp;</font></b></p>
  </td>
 </tr>
 <tr>
  <td width="35%" valign="top" bgcolor="#cceeff" style="background:#CCEEFF;padding:0in .7pt 0in .7pt;width:35.62%;">
  <p align="left" style="font-size:12.0pt;margin:0in 0in .0001pt 10.0pt;page-break-after:avoid;text-align:left;text-indent:-10.0pt;">&nbsp;</p>
  </td>
  <td width="1%" valign="bottom" bgcolor="#cceeff" style="background:#CCEEFF;padding:0in .7pt 0in .7pt;width:1.12%;">
  <p align="left" style="font-size:12.0pt;margin:0in 0in .0001pt;page-break-after:avoid;text-align:left;text-indent:0in;">&nbsp;</p>
  </td>
  <td width="13%" valign="bottom" bgcolor="#cceeff" style="background:#CCEEFF;padding:0in .7pt 0in .7pt;width:13.3%;">
  <p align="right" style="font-size:12.0pt;margin:0in 0in .0001pt;page-break-after:avoid;text-align:right;text-indent:0in;">&nbsp;</p>
  </td>
  <td width="1%" valign="bottom" bgcolor="#cceeff" style="background:#CCEEFF;padding:0in .7pt 0in .7pt;width:1.1%;">
  <p align="left" style="font-size:12.0pt;margin:0in 0in .0001pt;page-break-after:avoid;text-align:left;text-indent:0in;">&nbsp;</p>
  </td>
  <td width="16%" colspan="2" valign="bottom" bgcolor="#cceeff" style="background:#CCEEFF;padding:0in .7pt 0in .7pt;width:16.64%;">
  <p align="right" style="font-size:12.0pt;margin:0in 0in .0001pt;page-break-after:avoid;text-align:right;text-indent:0in;">&nbsp;</p>
  </td>
  <td width="1%" valign="bottom" bgcolor="#cceeff" style="background:#CCEEFF;padding:0in .7pt 0in .7pt;width:1.1%;">
  <p align="left" style="font-size:12.0pt;margin:0in 0in .0001pt;page-break-after:avoid;text-align:left;text-indent:0in;">&nbsp;</p>
  </td>
  <td width="15%" colspan="2" valign="bottom" bgcolor="#cceeff" style="background:#CCEEFF;padding:0in .7pt 0in .7pt;width:15.52%;">
  <p align="right" style="font-size:12.0pt;margin:0in 0in .0001pt;page-break-after:avoid;text-align:right;text-indent:0in;">&nbsp;</p>
  </td>
  <td width="1%" valign="bottom" bgcolor="#cceeff" style="background:#CCEEFF;padding:0in .7pt 0in .7pt;width:1.1%;">
  <p align="left" style="font-size:12.0pt;margin:0in 0in .0001pt;page-break-after:avoid;text-align:left;text-indent:0in;">&nbsp;</p>
  </td>
  <td width="13%" colspan="2" valign="bottom" bgcolor="#cceeff" style="background:#CCEEFF;padding:0in .7pt 0in .7pt;width:13.32%;">
  <p align="right" style="font-size:12.0pt;margin:0in 0in .0001pt;page-break-after:avoid;text-align:right;text-indent:0in;">&nbsp;</p>
  </td>
  <td width="1%" valign="bottom" bgcolor="#cceeff" style="background:#CCEEFF;padding:0in .7pt 0in .7pt;width:1.18%;">
  <p align="left" style="font-size:12.0pt;margin:0in 0in .0001pt;page-break-after:avoid;text-align:left;text-indent:0in;">&nbsp;</p>
  </td>
 </tr>
 <tr>
  <td width="35%" valign="top" style="padding:0in .7pt 0in .7pt;width:35.62%;">
  <p align="left" style="margin:0in 0in .0001pt 10.0pt;page-break-after:avoid;text-align:left;text-indent:-10.0pt;"><b><font size="2" face="Times New Roman" style="font-size:10.0pt;font-weight:bold;letter-spacing:-.1pt;">Total
  Registration Fees</font></b></p>
  </td>
  <td width="1%" valign="bottom" style="padding:0in .7pt 0in .7pt;width:1.12%;">
  <p align="left" style="font-size:1.0pt;margin:0in 0in .0001pt;page-break-after:avoid;text-align:left;text-indent:0in;">&nbsp;</p>
  </td>
  <td width="13%" valign="bottom" style="padding:0in .7pt 0in .7pt;width:13.3%;">
  <p align="right" style="font-size:1.0pt;margin:0in 0in .0001pt;page-break-after:avoid;text-align:right;text-indent:0in;">&nbsp;</p>
  </td>
  <td width="1%" valign="bottom" style="padding:0in .7pt 0in .7pt;width:1.1%;">
  <p align="left" style="margin:0in 0in .0001pt;page-break-after:avoid;text-align:left;text-indent:0in;"><b><font size="2" face="Times New Roman" style="font-size:1.0pt;font-weight:bold;letter-spacing:-.1pt;">&nbsp;</font></b></p>
  </td>
  <td width="16%" colspan="2" valign="bottom" style="padding:0in .7pt 0in .7pt;width:16.64%;">
  <p align="right" style="font-size:1.0pt;margin:0in 0in .0001pt;page-break-after:avoid;text-align:right;text-indent:0in;">&nbsp;</p>
  </td>
  <td width="1%" valign="bottom" style="padding:0in .7pt 0in .7pt;width:1.1%;">
  <p align="left" style="margin:0in 0in .0001pt;page-break-after:avoid;text-align:left;text-indent:0in;"><b><font size="2" face="Times New Roman" style="font-size:1.0pt;font-weight:bold;letter-spacing:-.1pt;">&nbsp;</font></b></p>
  </td>
  <td width="15%" colspan="2" valign="bottom" style="padding:0in .7pt 0in .7pt;width:15.52%;">
  <p align="right" style="font-size:1.0pt;margin:0in 0in .0001pt;page-break-after:avoid;text-align:right;text-indent:0in;">&nbsp;</p>
  </td>
  <td width="1%" valign="bottom" style="padding:0in .7pt 0in .7pt;width:1.1%;">
  <p align="left" style="margin:0in 0in .0001pt;page-break-after:avoid;text-align:left;text-indent:0in;"><b><font size="2" face="Times New Roman" style="font-size:1.0pt;font-weight:bold;letter-spacing:-.1pt;">&nbsp;</font></b></p>
  </td>
  <td width="4%" valign="bottom" style="padding:0in .7pt 0in .7pt;width:4.44%;">
  <p align="left" style="margin:0in 0in .0001pt;page-break-after:avoid;text-align:left;text-indent:0in;"><b><font size="2" face="Times New Roman" style="font-size:10.0pt;font-weight:bold;letter-spacing:-.1pt;">$</font></b></p>
  </td>
  <td width="8%" valign="bottom" style="padding:0in .7pt 0in .7pt;width:8.88%;">
  <p align="right" style="margin:0in 0in .0001pt;page-break-after:avoid;text-align:right;text-indent:0in;"><b><font size="2" face="Times New Roman" style="font-size:10.0pt;font-weight:bold;letter-spacing:-.1pt;">567.60</font></b></p>
  </td>
  <td width="1%" valign="bottom" style="padding:0in .7pt 0in .7pt;width:1.18%;">
  <p align="left" style="margin:0in 0in .0001pt;page-break-after:avoid;text-align:left;text-indent:0in;"><b><font size="2" face="Times New Roman" style="font-size:1.0pt;font-weight:bold;letter-spacing:-.1pt;">&nbsp;</font></b></p>
  </td>
 </tr>
</table>


<div align="left" style="margin:0in 0in .0001pt;text-align:left;text-indent:0in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">

<hr size="1" width="25%" noshade color="black" align="left">

</font></div>


<p align="left" style="margin:0in 0in .0001pt .25in;text-align:left;text-indent:-.25in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">(1)</font><font size="1" style="font-size:3.0pt;">&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; </font><font size="2" style="font-size:10.0pt;">The Proposed Maximum Offering Price Per
Share has been estimated in accordance with Rule 457(h) under the Securities
Act of 1933 solely for the purpose of calculating the registration fee.&#160; No options have been granted with respect to
such shares.&#160; The computation is based
upon the average of the high and low price of the Common Stock as reported on the
Nasdaq National Market on May 31, 2002, because the price at which the options
to be granted in the future may be exercised is not currently determinable.</font></p>

<p align="left" style="margin:12.0pt 0in .0001pt .25in;text-align:left;text-indent:-.25in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">(2)</font><font size="1" style="font-size:3.0pt;">&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; </font><font size="2" style="font-size:10.0pt;">The Proposed Maximum Offering Price Per
Share has been estimated in accordance with Rule 457(h) under the Securities
Act of 1933 solely for the purpose of calculating the registration fee.&#160; The computation is based upon 85% (see
explanation in following sentence) of the average of the high and low price of
the Common Stock as reported on the Nasdaq National Market on May 31, 2002,
because the price at which the options to be granted in the future may be
exercised is not currently determinable.&#160;
Pursuant to the Employee Stock Purchase Plan, which plan is incorporated
by reference herein, the Purchase Price of a share of Common Stock shall mean
an amount equal to 85% of the Fair Market Value of a share of Common Stock on
the Enrollment Date or the Exercise Date, whichever is lower.</font></p>

<p align="left" style="margin:0in 0in .0001pt;text-align:left;text-indent:0in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>

<div style="border:none;border-bottom:double windowtext 9.0pt;padding:0in 0in 0in 0in;">

<p align="left" style="border:none;margin:0in 0in .0001pt;padding:0in;text-align:left;text-indent:0in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>

</div>

<p style="font-weight:bold;margin:12.0pt 0in .0001pt;text-align:center;"><b><font size="2" face="Times New Roman" style="font-size:10.0pt;font-weight:normal;letter-spacing:-.1pt;">&nbsp;</font></b></p>


<div align="left" style="margin:12.0pt 0in .0001pt;text-align:left;text-indent:0in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">

<hr size="2" width="100%" noshade color="gray" align="left">

</font></div>

<font size="2" face="Times New Roman" style="font-size:10.0pt;">
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<p style="margin:0in 0in .0001pt;text-align:justify;text-indent:.5in;"><font size="3" face="Times New Roman" style="font-size:12.0pt;">&nbsp;</font></p>

<p style="font-weight:bold;margin:12.0pt 0in .0001pt;text-align:center;"><b><font size="2" face="Times New Roman" style="font-size:10.0pt;">CIPHERGEN BIOSYSTEMS,
INC.</font></b></p>

<p style="font-weight:bold;margin:0in 0in .0001pt;text-align:center;"><b><font size="2" face="Times New Roman" style="font-size:10.0pt;">REGISTRATION
STATEMENT ON FORM S-8</font></b></p>

<p style="font-weight:bold;margin:12.0pt 0in .0001pt;text-align:center;"><b><font size="2" face="Times New Roman" style="font-size:10.0pt;">EXPLANATORY NOTE</font></b></p>

<p align="left" style="margin:12.0pt 0in .0001pt;text-align:left;text-indent:.25in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">The contents of
the Registration Statement No. 333-53530 on Form S-8 as filed with the
Securities and Exchange Commission (the &#147;Commission&#148;) on January 11, 2001 and
May 21, 2001 are hereby incorporated herein by reference to the extent not replaced
hereby.</font></p>

<p align="left" style="font-weight:bold;margin:12.0pt 0in .0001pt;text-align:left;"><b><font size="2" face="Times New Roman" style="font-size:10.0pt;font-weight:normal;">&#160;&#160;&#160;&#160;&#160;&#160;&#160; The
purpose of this Form S-8 is to register the following:</font></b></p>

<p align="left" style="font-weight:bold;margin:12.0pt 0in .0001pt .75in;text-align:left;text-indent:-.5in;"><b><font size="2" face="Times New Roman" style="font-size:10.0pt;font-weight:normal;">(i)</font></b><font size="1" style="font-size:3.0pt;font-weight:normal;">&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; </font><font size="2" style="font-size:10.0pt;font-weight:normal;">An additional
1,150,000 shares of Common Stock of Ciphergen Biosystems, Inc. (the
&#147;Registrant&#148;) that are available for issuance under the 2000 Stock Plan, as
amended (the &#147;Plan&#148;), to reflect an additional 1,150,000 shares authorized for
issuance under the Plan by the Registrant&#146;s Board of Directors.</font></p>

<p align="left" style="margin:12.0pt 0in .0001pt .75in;text-align:left;text-indent:-.5in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">(ii)</font><font size="1" style="font-size:3.0pt;">&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; </font><font size="2" style="font-size:10.0pt;">An additional 150,000 shares of Common
Stock of Ciphergen Biosystems, Inc. (the &#147;Registrant&#148;) that are available for
issuance under the 2000 Employee Stock Purchase Plan, as amended (&#147;ESPP&#148;), to
reflect an additional 150,000 shares authorized for issuance under the ESPP by
the Registrant&#146;s Board of Directors.</font></p>

<p align="left" style="margin:12.0pt 0in .0001pt .25in;text-align:left;text-indent:0in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>

<p style="font-weight:bold;margin:12.0pt 0in .0001pt;text-align:center;"><b><font size="2" face="Times New Roman" style="font-size:10.0pt;">PART II</font></b></p>

<p style="font-weight:bold;margin:0in 0in .0001pt;text-align:center;"><b><font size="2" face="Times New Roman" style="font-size:10.0pt;">INFORMATION
REQUIRED IN THE REGISTRATION STATEMENT</font></b></p>

<p align="left" style="margin:12.0pt 0in .0001pt;text-align:left;text-indent:0in;"><b><font size="2" face="Times New Roman" style="font-size:10.0pt;font-weight:bold;">Item 3.&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; <u>Information Incorporated by
Reference</u>.</font></b></p>

<p align="left" style="margin:12.0pt 0in;text-align:left;text-indent:.5in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">The following
documents and information previously filed with the Securities and Exchange
Commission are hereby incorporated herein by reference:</font></p>

<p align="left" style="margin:0in 0in .0001pt 58.5pt;text-align:left;text-indent:-22.5pt;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">(a)</font><font size="1" style="font-size:3.0pt;">&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; </font><font size="2" style="font-size:10.0pt;">The Registrant&#146;s Annual Report filed on
Form 10-K (File No. 000-31617) for the fiscal year ended December&nbsp;31,
2001.</font></p>

<p align="left" style="margin:12.0pt 0in .0001pt 58.5pt;text-align:left;text-indent:-22.5pt;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">(b)</font><font size="1" style="font-size:3.0pt;">&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; </font><font size="2" style="font-size:10.0pt;">The Registrant&#146;s proxy statement for the 2002 Annual
Meeting of Stockholders.</font></p>

<p align="left" style="margin:12.0pt 0in .0001pt 58.5pt;text-align:left;text-indent:-22.5pt;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">(c)</font><font size="1" style="font-size:3.0pt;">&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; </font><font size="2" style="font-size:10.0pt;">The Registrant&#146;s Quarterly Report filed on Form 10-Q
(File No. 000-31617) for the quarterly period ended March&nbsp;31, 2002.</font></p>

<p align="left" style="margin:12.0pt 0in .0001pt 58.5pt;text-align:left;text-indent:-22.5pt;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">(d)</font><font size="1" style="font-size:3.0pt;">&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; </font><font size="2" style="font-size:10.0pt;">The description of the Common Stock of
the Registrant that is contained in the Registration Statement on Form 8-A
filed pursuant to Section&nbsp;12 of the Securities Exchange Act of 1934 (the
&#147;Exchange Act&#148;) on September&nbsp;22, 2000.</font></p>

<p align="left" style="margin:12.0pt 0in .0001pt 58.5pt;text-align:left;text-indent:-22.5pt;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">(e)</font><font size="1" style="font-size:3.0pt;">&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; </font><font size="2" style="font-size:10.0pt;">All documents filed by the Registrant
pursuant to Sections&nbsp;13(a),&nbsp;13(c),&nbsp;14 and 15(d) of the Exchange
Act subsequent to the filing of this Registration Statement and prior to the
filing of a post-effective amendment that indicates that all securities offered
have been sold or that deregisters all securities then remaining unsold, shall
be deemed to be incorporated by reference in this Registration Statement and to
be part hereof from the date of filing of such documents.</font></p>

<p align="center" style="margin:12.0pt 0in .0001pt;text-align:center;text-indent:0in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>

<p align="center" style="margin:12.0pt 0in .0001pt;text-align:center;text-indent:0in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">II-1</font></p>


<div align="left" style="margin:12.0pt 0in .0001pt;text-align:left;text-indent:0in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">

<hr size="2" width="100%" noshade color="gray" align="left">

</font></div>

<font size="2" face="Times New Roman" style="font-size:10.0pt;">
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<p align="center" style="font-size:12.0pt;margin:12.0pt 0in .0001pt;text-align:center;text-indent:0in;">&nbsp;</p>

<p align="left" style="margin:12.0pt 0in .0001pt;text-align:left;text-indent:0in;"><b><font size="2" face="Times New Roman" style="font-size:10.0pt;font-weight:bold;">Item 8.&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; <u>Exhibits</u>.</font></b></p>

<p align="left" style="margin:12.0pt 0in .0001pt;text-align:left;text-indent:.5in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">The Exhibits listed on
the accompanying Index to Exhibits are filed as part hereof, or incorporated by
reference into this Registration Statement.&#160;
(See Exhibit Index below).</font></p>

<p align="left" style="margin:12.0pt 0in .0001pt;text-align:left;text-indent:.5in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>

<p align="center" style="margin:12.0pt 0in .0001pt;text-align:center;text-indent:0in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">II-2</font></p>


<div align="left" style="margin:12.0pt 0in .0001pt;text-align:left;text-indent:0in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">

<hr size="2" width="100%" noshade color="gray" align="left">

</font></div>

<font size="2" face="Times New Roman" style="font-size:10.0pt;">
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<p align="center" style="font-size:12.0pt;margin:12.0pt 0in .0001pt;text-align:center;text-indent:0in;">&nbsp;</p>

<p align="center" style="margin:12.0pt 0in .0001pt;text-align:center;text-indent:0in;"><b><font size="2" face="Times New Roman" style="font-size:10.0pt;font-weight:bold;">SIGNATURES</font></b></p>

<p align="left" style="margin:12.0pt 0in .0001pt;text-align:left;text-indent:.5in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">Pursuant to the
requirements of the Securities Act of 1933, the Registrant certifies that it
has reasonable grounds to believe that it meets all of the requirements for
filing on Form&nbsp;S-8 and has duly caused this Registration Statement to be
signed on its behalf by the undersigned, thereunto duly authorized in the City
of Fremont, State of California on May 31, 2002.</font></p>

<p align="left" style="margin:12.0pt 0in .0001pt;text-align:left;text-indent:.5in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>

<table border="0" cellspacing="0" cellpadding="0" width="100%" style="border-collapse:collapse;width:100.0%;">
 <tr>
  <td width="50%" valign="top" style="padding:0in .7pt 0in .7pt;width:50.18%;">
  <p align="left" style="font-size:1.0pt;margin:0in 0in .0001pt;text-align:left;">&nbsp;</p>
  </td>
  <td width="49%" colspan="2" valign="top" style="padding:0in .7pt 0in .7pt;width:49.82%;">
  <p align="left" style="margin:0in 0in .0001pt;text-align:left;"><b><font size="2" face="Times New Roman" style="font-size:10.0pt;font-weight:bold;">CIPHERGEN
  BIOSYSTEMS, INC.</font></b></p>
  </td>
 </tr>
 <tr>
  <td width="50%" valign="top" style="padding:0in .7pt 0in .7pt;width:50.18%;">
  <p align="left" style="font-size:12.0pt;margin:0in 0in .0001pt;text-align:left;">&nbsp;</p>
  </td>
  <td width="49%" colspan="2" valign="top" style="padding:0in .7pt 0in .7pt;width:49.82%;">
  <p align="left" style="font-size:12.0pt;margin:0in 0in .0001pt;text-align:left;">&nbsp;</p>
  </td>
 </tr>
 <tr>
  <td width="50%" valign="top" style="padding:0in .7pt 0in .7pt;width:50.18%;">
  <p align="left" style="font-size:12.0pt;margin:0in 0in .0001pt;text-align:left;">&nbsp;</p>
  </td>
  <td width="49%" colspan="2" valign="top" style="padding:0in .7pt 0in .7pt;width:49.82%;">
  <p align="left" style="font-size:12.0pt;margin:0in 0in .0001pt;text-align:left;">&nbsp;</p>
  </td>
 </tr>
 <tr>
  <td width="50%" valign="top" style="padding:0in .7pt 0in .7pt;width:50.18%;">
  <p align="left" style="font-size:1.0pt;margin:0in 0in .0001pt;text-align:left;">&nbsp;</p>
  </td>
  <td width="4%" valign="top" style="padding:0in .7pt 0in .7pt;width:4.24%;">
  <p align="left" style="margin:0in 0in .0001pt;text-align:left;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">By:</font></p>
  </td>
  <td width="45%" valign="top" style="border:none;border-bottom:solid windowtext .5pt;padding:0in .7pt 0in .7pt;width:45.56%;">
  <p align="left" style="margin:0in 0in .0001pt;text-align:left;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">/s/ WILLIAM E. RICH</font></p>
  </td>
 </tr>
 <tr>
  <td width="50%" valign="top" style="padding:0in .7pt 0in .7pt;width:50.18%;">
  <p align="left" style="font-size:1.0pt;margin:0in 0in .0001pt;text-align:left;">&nbsp;</p>
  </td>
  <td width="4%" valign="top" style="padding:0in .7pt 0in .7pt;width:4.24%;">
  <p align="left" style="font-size:1.0pt;margin:0in 0in .0001pt;text-align:left;">&nbsp;</p>
  </td>
  <td width="45%" valign="top" style="padding:0in .7pt 0in .7pt;width:45.56%;">
  <p align="left" style="margin:0in 0in .0001pt;text-align:left;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">William E. Rich, Ph.D.</font></p>
  </td>
 </tr>
 <tr>
  <td width="50%" valign="top" style="padding:0in .7pt 0in .7pt;width:50.18%;">
  <p align="left" style="font-size:1.0pt;margin:0in 0in .0001pt;text-align:left;">&nbsp;</p>
  </td>
  <td width="4%" valign="top" style="padding:0in .7pt 0in .7pt;width:4.24%;">
  <p align="left" style="font-size:1.0pt;margin:0in 0in .0001pt;text-align:left;">&nbsp;</p>
  </td>
  <td width="45%" valign="top" style="padding:0in .7pt 0in .7pt;width:45.56%;">
  <p align="left" style="margin:0in 0in .0001pt;text-align:left;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">President and Chief Executive Officer</font></p>
  </td>
 </tr>
</table>

<p align="center" style="margin:12.0pt 0in .0001pt;text-align:center;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>

<p align="center" style="margin:12.0pt 0in .0001pt;text-align:center;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">II-3</font></p>


<div align="left" style="margin:12.0pt 0in .0001pt;text-align:left;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">

<hr size="2" width="100%" noshade color="gray" align="left">

</font></div>

<font size="2" face="Times New Roman" style="font-size:10.0pt;">
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<p align="center" style="font-size:12.0pt;margin:12.0pt 0in .0001pt;text-align:center;">&nbsp;</p>

<p style="font-weight:bold;margin:0in 0in .0001pt;text-align:center;"><b><font size="2" face="Times New Roman" style="font-size:10.0pt;">POWER
OF ATTORNEY</font></b></p>

<p align="left" style="margin:12.0pt 0in .0001pt;text-align:left;text-indent:.5in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">KNOW ALL PERSONS BY THESE
PRESENTS, that each person whose signature appears below constitutes and
appoints William&nbsp;E. Rich and Matthew J. Hogan, jointly and severally, his
or her attorney-in-fact, each with the power of substitution, for him in any
and all capacities, to sign any amendments to this Registration Statement on
Form&nbsp;S-8, and to file the same, with exhibits thereto and other documents
in connection therewith, with the Securities and Exchange Commission, hereby
ratifying and confirming all that each of said attorney-in-fact, or his
substitute or substitutes, may do or cause to be done by virtue hereof.</font></p>

<p align="left" style="margin:12.0pt 0in .0001pt;text-align:left;text-indent:.5in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">Pursuant to the
requirements of the Securities Act of 1933, this Registration Statement has
been signed by the following persons in the capacities and on the date
indicated.</font></p>

<p align="left" style="margin:0in 0in .0001pt;text-align:left;text-indent:0in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>

<table border="1" cellspacing="0" cellpadding="0" width="100%" style="border:none;border-collapse:collapse;width:100.0%;">
 <tr>
  <td width="40%" valign="top" style="border:none;border-bottom:solid windowtext .5pt;padding:0in .7pt 0in .7pt;width:40.26%;">
  <p align="center" style="margin:0in 0in .0001pt;text-align:center;text-indent:0in;"><b><font size="1" face="Times New Roman" style="font-size:8.0pt;font-weight:bold;">SIGNATURE</font></b></p>
  </td>
  <td width="2%" valign="bottom" style="border:none;padding:0in .7pt 0in .7pt;width:2.64%;">
  <p align="center" style="font-size:1.0pt;margin:0in 0in .0001pt;text-align:center;text-indent:0in;">&nbsp;</p>
  </td>
  <td width="42%" valign="top" style="border:none;border-bottom:solid windowtext .5pt;padding:0in .7pt 0in .7pt;width:42.12%;">
  <p align="center" style="margin:0in 0in .0001pt;text-align:center;text-indent:0in;"><b><font size="1" face="Times New Roman" style="font-size:8.0pt;font-weight:bold;">TITLE</font></b></p>
  </td>
  <td width="2%" valign="bottom" style="border:none;padding:0in .7pt 0in .7pt;width:2.64%;">
  <p align="center" style="font-size:1.0pt;margin:0in 0in .0001pt;text-align:center;text-indent:0in;">&nbsp;</p>
  </td>
  <td width="12%" valign="top" style="border:none;border-bottom:solid windowtext .5pt;padding:0in .7pt 0in .7pt;width:12.34%;">
  <p align="center" style="margin:0in 0in .0001pt;text-align:center;text-indent:0in;"><b><font size="1" face="Times New Roman" style="font-size:8.0pt;font-weight:bold;">DATE</font></b></p>
  </td>
 </tr>
 <tr>
  <td width="40%" valign="top" style="border:none;padding:0in .7pt 0in .7pt;width:40.26%;">
  <p align="center" style="font-size:12.0pt;margin:0in 0in .0001pt;text-align:center;text-indent:0in;">&nbsp;</p>
  </td>
  <td width="2%" valign="bottom" style="border:none;padding:0in .7pt 0in .7pt;width:2.64%;">
  <p align="center" style="font-size:12.0pt;margin:0in 0in .0001pt;text-align:center;text-indent:0in;">&nbsp;</p>
  </td>
  <td width="42%" valign="top" style="border:none;padding:0in .7pt 0in .7pt;width:42.12%;">
  <p align="center" style="font-size:12.0pt;margin:0in 0in .0001pt;text-align:center;text-indent:0in;">&nbsp;</p>
  </td>
  <td width="2%" valign="bottom" style="border:none;padding:0in .7pt 0in .7pt;width:2.64%;">
  <p align="center" style="font-size:12.0pt;margin:0in 0in .0001pt;text-align:center;text-indent:0in;">&nbsp;</p>
  </td>
  <td width="12%" valign="top" style="border:none;padding:0in .7pt 0in .7pt;width:12.34%;">
  <p align="center" style="font-size:12.0pt;margin:0in 0in .0001pt;text-align:center;text-indent:0in;">&nbsp;</p>
  </td>
 </tr>
 <tr height="15" style="height:11.25pt;">
  <td width="40%" height="15" valign="top" style="border:none;border-bottom:solid windowtext .5pt;height:11.25pt;padding:0in .7pt 0in .7pt;width:40.26%;">
  <p align="left" style="margin:0in 0in .0001pt;text-align:left;text-indent:0in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">/s/ WILLIAM E. RICH</font></p>
  </td>
  <td width="2%" rowspan="2" valign="bottom" style="border:none;height:11.25pt;padding:0in .7pt 0in .7pt;width:2.64%;">
  <p align="left" style="font-size:1.0pt;margin:0in 0in .0001pt;text-align:left;text-indent:0in;">&nbsp;</p>
  </td>
  <td width="42%" rowspan="2" valign="top" style="border:none;height:11.25pt;padding:0in .7pt 0in .7pt;width:42.12%;">
  <p align="left" style="margin:0in 0in .0001pt;text-align:left;text-indent:0in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">President and Chief Executive Officer (Principal Executive Officer)</font></p>
  </td>
  <td width="2%" rowspan="2" valign="bottom" style="border:none;height:11.25pt;padding:0in .7pt 0in .7pt;width:2.64%;">
  <p align="left" style="font-size:1.0pt;margin:0in 0in .0001pt;text-align:left;text-indent:0in;">&nbsp;</p>
  </td>
  <td width="12%" rowspan="2" valign="top" style="border:none;height:11.25pt;padding:0in .7pt 0in .7pt;width:12.34%;">
  <p align="left" style="margin:0in 0in .0001pt;text-align:left;text-indent:0in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">June 4, 2002</font></p>
  </td>
 </tr>
 <tr height="15" style="height:11.25pt;">
  <td width="40%" height="15" valign="top" style="border:none;height:11.25pt;padding:0in .7pt 0in .7pt;width:40.26%;">
  <p align="left" style="margin:0in 0in .0001pt .5in;text-align:left;text-indent:0in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">William E. Rich</font></p>
  </td>
 </tr>
 <tr height="15" style="height:11.25pt;">
  <td width="40%" height="15" valign="top" style="border:none;height:11.25pt;padding:0in .7pt 0in .7pt;width:40.26%;">
  <p align="left" style="font-size:12.0pt;margin:0in 0in .0001pt;text-align:left;text-indent:0in;">&nbsp;</p>
  </td>
  <td width="2%" height="15" valign="bottom" style="border:none;height:11.25pt;padding:0in .7pt 0in .7pt;width:2.64%;">
  <p align="left" style="font-size:12.0pt;margin:0in 0in .0001pt;text-align:left;text-indent:0in;">&nbsp;</p>
  </td>
  <td width="42%" height="15" valign="top" style="border:none;height:11.25pt;padding:0in .7pt 0in .7pt;width:42.12%;">
  <p align="left" style="font-size:12.0pt;margin:0in 0in .0001pt;text-align:left;text-indent:0in;">&nbsp;</p>
  </td>
  <td width="2%" height="15" valign="bottom" style="border:none;height:11.25pt;padding:0in .7pt 0in .7pt;width:2.64%;">
  <p align="left" style="font-size:12.0pt;margin:0in 0in .0001pt;text-align:left;text-indent:0in;">&nbsp;</p>
  </td>
  <td width="12%" height="15" valign="top" style="border:none;height:11.25pt;padding:0in .7pt 0in .7pt;width:12.34%;">
  <p align="left" style="font-size:12.0pt;margin:0in 0in .0001pt;text-align:left;text-indent:0in;">&nbsp;</p>
  </td>
 </tr>
 <tr height="15" style="height:11.25pt;">
  <td width="40%" height="15" valign="top" style="border:none;border-bottom:solid windowtext .5pt;height:11.25pt;padding:0in .7pt 0in .7pt;width:40.26%;">
  <p align="left" style="margin:0in 0in .0001pt;text-align:left;text-indent:0in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">/s/ MATTHEW J. HOGAN</font></p>
  </td>
  <td width="2%" rowspan="2" valign="bottom" style="border:none;height:11.25pt;padding:0in .7pt 0in .7pt;width:2.64%;">
  <p align="left" style="font-size:1.0pt;margin:0in 0in .0001pt;text-align:left;text-indent:0in;">&nbsp;</p>
  </td>
  <td width="42%" rowspan="2" valign="top" style="border:none;height:11.25pt;padding:0in .7pt 0in .7pt;width:42.12%;">
  <p align="left" style="margin:0in 0in .0001pt;text-align:left;text-indent:0in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">Vice President and Chief Financial Officer (Principal Financial
  Officer)</font></p>
  </td>
  <td width="2%" rowspan="2" valign="bottom" style="border:none;height:11.25pt;padding:0in .7pt 0in .7pt;width:2.64%;">
  <p align="left" style="font-size:1.0pt;margin:0in 0in .0001pt;text-align:left;text-indent:0in;">&nbsp;</p>
  </td>
  <td width="12%" rowspan="2" valign="top" style="border:none;height:11.25pt;padding:0in .7pt 0in .7pt;width:12.34%;">
  <p align="left" style="margin:0in 0in .0001pt;text-align:left;text-indent:0in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">June 4, 2002</font></p>
  </td>
 </tr>
 <tr height="15" style="height:11.25pt;">
  <td width="40%" height="15" valign="top" style="border:none;height:11.25pt;padding:0in .7pt 0in .7pt;width:40.26%;">
  <p align="left" style="margin:0in 0in .0001pt .5in;text-align:left;text-indent:0in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">Matthew J. Hogan</font></p>
  </td>
 </tr>
 <tr>
  <td width="40%" valign="top" style="border:none;padding:0in .7pt 0in .7pt;width:40.26%;">
  <p align="left" style="font-size:12.0pt;margin:0in 0in .0001pt;text-align:left;text-indent:0in;">&nbsp;</p>
  </td>
  <td width="2%" valign="bottom" style="border:none;padding:0in .7pt 0in .7pt;width:2.64%;">
  <p align="left" style="font-size:12.0pt;margin:0in 0in .0001pt;text-align:left;text-indent:0in;">&nbsp;</p>
  </td>
  <td width="42%" valign="top" style="border:none;padding:0in .7pt 0in .7pt;width:42.12%;">
  <p align="left" style="font-size:12.0pt;margin:0in 0in .0001pt;text-align:left;text-indent:0in;">&nbsp;</p>
  </td>
  <td width="2%" valign="bottom" style="border:none;padding:0in .7pt 0in .7pt;width:2.64%;">
  <p align="left" style="font-size:12.0pt;margin:0in 0in .0001pt;text-align:left;text-indent:0in;">&nbsp;</p>
  </td>
  <td width="12%" valign="top" style="border:none;padding:0in .7pt 0in .7pt;width:12.34%;">
  <p align="left" style="font-size:12.0pt;margin:0in 0in .0001pt;text-align:left;text-indent:0in;">&nbsp;</p>
  </td>
 </tr>
 <tr height="8" style="height:5.65pt;">
  <td width="40%" height="8" valign="top" style="border:none;border-bottom:solid windowtext .5pt;height:5.65pt;padding:0in .7pt 0in .7pt;width:40.26%;">
  <p align="left" style="margin:0in 0in .0001pt;text-align:left;text-indent:0in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">/s/ DANIEL M. CASERZA</font></p>
  </td>
  <td width="2%" rowspan="2" valign="bottom" style="border:none;height:5.65pt;padding:0in .7pt 0in .7pt;width:2.64%;">
  <p align="left" style="font-size:1.0pt;margin:0in 0in .0001pt;text-align:left;text-indent:0in;">&nbsp;</p>
  </td>
  <td width="42%" rowspan="2" valign="top" style="border:none;height:5.65pt;padding:0in .7pt 0in .7pt;width:42.12%;">
  <p align="left" style="margin:0in 0in .0001pt;text-align:left;text-indent:0in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">Corporate Controller (Principal Accounting Officer)</font></p>
  </td>
  <td width="2%" rowspan="2" valign="bottom" style="border:none;height:5.65pt;padding:0in .7pt 0in .7pt;width:2.64%;">
  <p align="left" style="font-size:1.0pt;margin:0in 0in .0001pt;text-align:left;text-indent:0in;">&nbsp;</p>
  </td>
  <td width="12%" rowspan="2" valign="top" style="border:none;height:5.65pt;padding:0in .7pt 0in .7pt;width:12.34%;">
  <p align="left" style="margin:0in 0in .0001pt;text-align:left;text-indent:0in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">June 4, 2002</font></p>
  </td>
 </tr>
 <tr height="7" style="height:5.6pt;">
  <td width="40%" height="7" valign="top" style="border:none;height:5.6pt;padding:0in .7pt 0in .7pt;width:40.26%;">
  <p align="left" style="margin:0in 0in .0001pt .5in;text-align:left;text-indent:0in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">Daniel M. Caserza</font></p>
  </td>
 </tr>
 <tr>
  <td width="40%" valign="top" style="border:none;padding:0in .7pt 0in .7pt;width:40.26%;">
  <p align="left" style="font-size:12.0pt;margin:0in 0in .0001pt;text-align:left;text-indent:0in;">&nbsp;</p>
  </td>
  <td width="2%" valign="bottom" style="border:none;padding:0in .7pt 0in .7pt;width:2.64%;">
  <p align="left" style="font-size:12.0pt;margin:0in 0in .0001pt;text-align:left;text-indent:0in;">&nbsp;</p>
  </td>
  <td width="42%" valign="top" style="border:none;padding:0in .7pt 0in .7pt;width:42.12%;">
  <p align="left" style="font-size:12.0pt;margin:0in 0in .0001pt;text-align:left;text-indent:0in;">&nbsp;</p>
  </td>
  <td width="2%" valign="bottom" style="border:none;padding:0in .7pt 0in .7pt;width:2.64%;">
  <p align="left" style="font-size:12.0pt;margin:0in 0in .0001pt;text-align:left;text-indent:0in;">&nbsp;</p>
  </td>
  <td width="12%" valign="top" style="border:none;padding:0in .7pt 0in .7pt;width:12.34%;">
  <p align="left" style="font-size:12.0pt;margin:0in 0in .0001pt;text-align:left;text-indent:0in;">&nbsp;</p>
  </td>
 </tr>
 <tr height="8" style="height:5.65pt;">
  <td width="40%" height="8" valign="top" style="border:none;border-bottom:solid windowtext .5pt;height:5.65pt;padding:0in .7pt 0in .7pt;width:40.26%;">
  <p align="left" style="margin:0in 0in .0001pt;text-align:left;text-indent:0in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">/s/ JOHN A. YOUNG</font></p>
  </td>
  <td width="2%" rowspan="2" valign="bottom" style="border:none;height:5.65pt;padding:0in .7pt 0in .7pt;width:2.64%;">
  <p align="left" style="font-size:1.0pt;margin:0in 0in .0001pt;text-align:left;text-indent:0in;">&nbsp;</p>
  </td>
  <td width="42%" rowspan="2" valign="top" style="border:none;height:5.65pt;padding:0in .7pt 0in .7pt;width:42.12%;">
  <p align="left" style="margin:0in 0in .0001pt;text-align:left;text-indent:0in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">Director</font></p>
  </td>
  <td width="2%" rowspan="2" valign="bottom" style="border:none;height:5.65pt;padding:0in .7pt 0in .7pt;width:2.64%;">
  <p align="left" style="font-size:1.0pt;margin:0in 0in .0001pt;text-align:left;text-indent:0in;">&nbsp;</p>
  </td>
  <td width="12%" rowspan="2" valign="top" style="border:none;height:5.65pt;padding:0in .7pt 0in .7pt;width:12.34%;">
  <p align="left" style="margin:0in 0in .0001pt;text-align:left;text-indent:0in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">June 4, 2002</font></p>
  </td>
 </tr>
 <tr height="7" style="height:5.6pt;">
  <td width="40%" height="7" valign="top" style="border:none;height:5.6pt;padding:0in .7pt 0in .7pt;width:40.26%;">
  <p align="left" style="margin:0in 0in .0001pt .5in;text-align:left;text-indent:0in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">John A. Young</font></p>
  </td>
 </tr>
 <tr>
  <td width="40%" valign="top" style="border:none;padding:0in .7pt 0in .7pt;width:40.26%;">
  <p align="left" style="font-size:12.0pt;margin:0in 0in .0001pt;text-align:left;text-indent:0in;">&nbsp;</p>
  </td>
  <td width="2%" valign="bottom" style="border:none;padding:0in .7pt 0in .7pt;width:2.64%;">
  <p align="left" style="font-size:12.0pt;margin:0in 0in .0001pt;text-align:left;text-indent:0in;">&nbsp;</p>
  </td>
  <td width="42%" valign="top" style="border:none;padding:0in .7pt 0in .7pt;width:42.12%;">
  <p align="left" style="font-size:12.0pt;margin:0in 0in .0001pt;text-align:left;text-indent:0in;">&nbsp;</p>
  </td>
  <td width="2%" valign="bottom" style="border:none;padding:0in .7pt 0in .7pt;width:2.64%;">
  <p align="left" style="font-size:12.0pt;margin:0in 0in .0001pt;text-align:left;text-indent:0in;">&nbsp;</p>
  </td>
  <td width="12%" valign="top" style="border:none;padding:0in .7pt 0in .7pt;width:12.34%;">
  <p align="left" style="font-size:12.0pt;margin:0in 0in .0001pt;text-align:left;text-indent:0in;">&nbsp;</p>
  </td>
 </tr>
 <tr height="8" style="height:5.65pt;">
  <td width="40%" height="8" valign="top" style="border:none;border-bottom:solid windowtext .5pt;height:5.65pt;padding:0in .7pt 0in .7pt;width:40.26%;">
  <p align="left" style="margin:0in 0in .0001pt;text-align:left;text-indent:0in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">/s/ MICHAEL J. CALLAGHAN</font></p>
  </td>
  <td width="2%" rowspan="2" valign="bottom" style="border:none;height:5.65pt;padding:0in .7pt 0in .7pt;width:2.64%;">
  <p align="left" style="font-size:1.0pt;margin:0in 0in .0001pt;text-align:left;text-indent:0in;">&nbsp;</p>
  </td>
  <td width="42%" rowspan="2" valign="top" style="border:none;height:5.65pt;padding:0in .7pt 0in .7pt;width:42.12%;">
  <p align="left" style="margin:0in 0in .0001pt;text-align:left;text-indent:0in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">Director</font></p>
  </td>
  <td width="2%" rowspan="2" valign="bottom" style="border:none;height:5.65pt;padding:0in .7pt 0in .7pt;width:2.64%;">
  <p align="left" style="font-size:1.0pt;margin:0in 0in .0001pt;text-align:left;text-indent:0in;">&nbsp;</p>
  </td>
  <td width="12%" rowspan="2" valign="top" style="border:none;height:5.65pt;padding:0in .7pt 0in .7pt;width:12.34%;">
  <p align="left" style="margin:0in 0in .0001pt;text-align:left;text-indent:0in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">June 4, 2002</font></p>
  </td>
 </tr>
 <tr height="7" style="height:5.6pt;">
  <td width="40%" height="7" valign="top" style="border:none;height:5.6pt;padding:0in .7pt 0in .7pt;width:40.26%;">
  <p align="left" style="margin:0in 0in .0001pt .5in;text-align:left;text-indent:0in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">Michael J. Callaghan</font></p>
  </td>
 </tr>
 <tr>
  <td width="40%" valign="top" style="border:none;padding:0in .7pt 0in .7pt;width:40.26%;">
  <p align="left" style="font-size:12.0pt;margin:0in 0in .0001pt;text-align:left;text-indent:0in;">&nbsp;</p>
  </td>
  <td width="2%" valign="bottom" style="border:none;padding:0in .7pt 0in .7pt;width:2.64%;">
  <p align="left" style="font-size:12.0pt;margin:0in 0in .0001pt;text-align:left;text-indent:0in;">&nbsp;</p>
  </td>
  <td width="42%" valign="top" style="border:none;padding:0in .7pt 0in .7pt;width:42.12%;">
  <p align="left" style="font-size:12.0pt;margin:0in 0in .0001pt;text-align:left;text-indent:0in;">&nbsp;</p>
  </td>
  <td width="2%" valign="bottom" style="border:none;padding:0in .7pt 0in .7pt;width:2.64%;">
  <p align="left" style="font-size:12.0pt;margin:0in 0in .0001pt;text-align:left;text-indent:0in;">&nbsp;</p>
  </td>
  <td width="12%" valign="top" style="border:none;padding:0in .7pt 0in .7pt;width:12.34%;">
  <p align="left" style="font-size:12.0pt;margin:0in 0in .0001pt;text-align:left;text-indent:0in;">&nbsp;</p>
  </td>
 </tr>
 <tr height="8" style="height:5.65pt;">
  <td width="40%" height="8" valign="top" style="border:none;border-bottom:solid windowtext .5pt;height:5.65pt;padding:0in .7pt 0in .7pt;width:40.26%;">
  <p align="left" style="margin:0in 0in .0001pt;text-align:left;text-indent:0in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">/s/ WILLIAM R. GREEN</font></p>
  </td>
  <td width="2%" rowspan="2" valign="bottom" style="border:none;height:5.65pt;padding:0in .7pt 0in .7pt;width:2.64%;">
  <p align="left" style="font-size:1.0pt;margin:0in 0in .0001pt;text-align:left;text-indent:0in;">&nbsp;</p>
  </td>
  <td width="42%" rowspan="2" valign="top" style="border:none;height:5.65pt;padding:0in .7pt 0in .7pt;width:42.12%;">
  <p align="left" style="margin:0in 0in .0001pt;text-align:left;text-indent:0in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">Director</font></p>
  </td>
  <td width="2%" rowspan="2" valign="bottom" style="border:none;height:5.65pt;padding:0in .7pt 0in .7pt;width:2.64%;">
  <p align="left" style="font-size:1.0pt;margin:0in 0in .0001pt;text-align:left;text-indent:0in;">&nbsp;</p>
  </td>
  <td width="12%" rowspan="2" valign="top" style="border:none;height:5.65pt;padding:0in .7pt 0in .7pt;width:12.34%;">
  <p align="left" style="margin:0in 0in .0001pt;text-align:left;text-indent:0in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">June 4, 2002</font></p>
  </td>
 </tr>
 <tr height="7" style="height:5.6pt;">
  <td width="40%" height="7" valign="top" style="border:none;height:5.6pt;padding:0in .7pt 0in .7pt;width:40.26%;">
  <p align="left" style="margin:0in 0in .0001pt .5in;text-align:left;text-indent:0in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">William R. Green</font></p>
  </td>
 </tr>
 <tr>
  <td width="40%" valign="top" style="border:none;padding:0in .7pt 0in .7pt;width:40.26%;">
  <p align="left" style="font-size:12.0pt;margin:0in 0in .0001pt;text-align:left;text-indent:0in;">&nbsp;</p>
  </td>
  <td width="2%" valign="bottom" style="border:none;padding:0in .7pt 0in .7pt;width:2.64%;">
  <p align="left" style="font-size:12.0pt;margin:0in 0in .0001pt;text-align:left;text-indent:0in;">&nbsp;</p>
  </td>
  <td width="42%" valign="top" style="border:none;padding:0in .7pt 0in .7pt;width:42.12%;">
  <p align="left" style="font-size:12.0pt;margin:0in 0in .0001pt;text-align:left;text-indent:0in;">&nbsp;</p>
  </td>
  <td width="2%" valign="bottom" style="border:none;padding:0in .7pt 0in .7pt;width:2.64%;">
  <p align="left" style="font-size:12.0pt;margin:0in 0in .0001pt;text-align:left;text-indent:0in;">&nbsp;</p>
  </td>
  <td width="12%" valign="top" style="border:none;padding:0in .7pt 0in .7pt;width:12.34%;">
  <p align="left" style="font-size:12.0pt;margin:0in 0in .0001pt;text-align:left;text-indent:0in;">&nbsp;</p>
  </td>
 </tr>
 <tr height="8" style="height:5.65pt;">
  <td width="40%" height="8" valign="top" style="border:none;border-bottom:solid windowtext .5pt;height:5.65pt;padding:0in .7pt 0in .7pt;width:40.26%;">
  <p align="left" style="margin:0in 0in .0001pt;text-align:left;text-indent:0in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">/s/ JAMES L. RATHMANN</font></p>
  </td>
  <td width="2%" rowspan="2" valign="bottom" style="border:none;height:5.65pt;padding:0in .7pt 0in .7pt;width:2.64%;">
  <p align="left" style="font-size:1.0pt;margin:0in 0in .0001pt;text-align:left;text-indent:0in;">&nbsp;</p>
  </td>
  <td width="42%" rowspan="2" valign="top" style="border:none;height:5.65pt;padding:0in .7pt 0in .7pt;width:42.12%;">
  <p align="left" style="margin:0in 0in .0001pt;text-align:left;text-indent:0in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">Director</font></p>
  </td>
  <td width="2%" rowspan="2" valign="bottom" style="border:none;height:5.65pt;padding:0in .7pt 0in .7pt;width:2.64%;">
  <p align="left" style="font-size:1.0pt;margin:0in 0in .0001pt;text-align:left;text-indent:0in;">&nbsp;</p>
  </td>
  <td width="12%" rowspan="2" valign="top" style="border:none;height:5.65pt;padding:0in .7pt 0in .7pt;width:12.34%;">
  <p align="left" style="margin:0in 0in .0001pt;text-align:left;text-indent:0in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">June 4, 2002</font></p>
  </td>
 </tr>
 <tr height="7" style="height:5.6pt;">
  <td width="40%" height="7" valign="top" style="border:none;height:5.6pt;padding:0in .7pt 0in .7pt;width:40.26%;">
  <p align="left" style="margin:0in 0in .0001pt .5in;text-align:left;text-indent:0in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">James L. Rathmann</font></p>
  </td>
 </tr>
</table>

<p align="left" style="margin:0in 0in .0001pt;text-align:left;text-indent:0in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>

<p align="center" style="margin:0in 0in .0001pt;text-align:center;text-indent:0in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>

<p align="center" style="margin:0in 0in .0001pt;text-align:center;text-indent:0in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">II-4</font></p>


<div align="left" style="margin:0in 0in .0001pt;text-align:left;text-indent:0in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">

<hr size="2" width="100%" noshade color="gray" align="left">

</font></div>

<font size="2" face="Times New Roman" style="font-size:10.0pt;">
<!-- ZEQ.=1,SEQ=5,EFW="2081659",CP="CIPHERGEN BIOSYSTEMS, INC.",DN="1",CHK=478672,FOLIO='II-4',FILE="DISK038:[02PAL8.02PAL1798.EDGAR]S-8_1798.CHC",USER="DPHAMA",CD='Jun  5 11:31 2002' -->
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<p align="center" style="font-size:12.0pt;margin:0in 0in .0001pt;text-align:center;text-indent:0in;">&nbsp;</p>

<p align="center" style="margin:0in 0in .0001pt;text-align:center;text-indent:0in;"><b><font size="2" face="Times New Roman" style="font-size:10.0pt;font-weight:bold;">INDEX TO
EXHIBITS</font></b></p>

<p align="center" style="margin:0in 0in .0001pt;text-align:center;text-indent:0in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>

<table border="1" cellspacing="0" cellpadding="0" width="100%" style="border:none;border-collapse:collapse;width:100.0%;">
 <tr>
  <td width="15%" valign="top" style="border:none;border-bottom:solid windowtext .5pt;padding:0in .7pt 0in .7pt;width:15.12%;">
  <p align="center" style="margin:0in 0in .0001pt;text-align:center;text-indent:0in;"><b><font size="1" face="Times New Roman" style="font-size:8.0pt;font-weight:bold;">Exhibit Number</font></b></p>
  </td>
  <td width="2%" valign="bottom" style="border:none;padding:0in .7pt 0in .7pt;width:2.7%;">
  <p align="left" style="font-size:1.0pt;margin:0in 0in .0001pt;text-align:left;text-indent:0in;">&nbsp;</p>
  </td>
  <td width="82%" valign="top" style="border:none;border-bottom:solid windowtext .5pt;padding:0in .7pt 0in .7pt;width:82.18%;">
  <p align="center" style="margin:0in 0in .0001pt;text-align:center;text-indent:0in;"><b><font size="1" face="Times New Roman" style="font-size:8.0pt;font-weight:bold;">Exhibit Document</font></b></p>
  </td>
 </tr>
 <tr>
  <td width="15%" valign="top" style="border:none;padding:0in .7pt 0in .7pt;width:15.12%;">
  <p align="center" style="font-size:12.0pt;margin:0in 0in .0001pt;text-align:center;text-indent:0in;">&nbsp;</p>
  </td>
  <td width="2%" valign="bottom" style="border:none;padding:0in .7pt 0in .7pt;width:2.7%;">
  <p align="left" style="font-size:12.0pt;margin:0in 0in .0001pt;text-align:left;text-indent:0in;">&nbsp;</p>
  </td>
  <td width="82%" valign="top" style="border:none;padding:0in .7pt 0in .7pt;width:82.18%;">
  <p align="center" style="font-size:12.0pt;margin:0in 0in .0001pt;text-align:center;text-indent:0in;">&nbsp;</p>
  </td>
 </tr>
 <tr>
  <td width="15%" valign="top" style="border:none;padding:0in .7pt 0in .7pt;width:15.12%;">
  <p align="left" style="margin:0in 0in .0001pt 30.0pt;text-align:left;text-indent:0in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">4.1</font></p>
  </td>
  <td width="2%" valign="bottom" style="border:none;padding:0in .7pt 0in .7pt;width:2.7%;">
  <p align="left" style="font-size:1.0pt;margin:0in 0in .0001pt;text-align:left;text-indent:0in;">&nbsp;</p>
  </td>
  <td width="82%" valign="top" style="border:none;padding:0in .7pt 0in .7pt;width:82.18%;">
  <p align="left" style="margin:0in 0in .0001pt;text-align:left;text-indent:0in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">2000 Stock Plan (incorporated by reference to Exhibit 10.5 of the
  Form&nbsp;S-1)</font></p>
  </td>
 </tr>
 <tr>
  <td width="15%" valign="top" style="border:none;padding:0in .7pt 0in .7pt;width:15.12%;">
  <p align="left" style="font-size:12.0pt;margin:0in 0in .0001pt 30.0pt;text-align:left;text-indent:0in;">&nbsp;</p>
  </td>
  <td width="2%" valign="bottom" style="border:none;padding:0in .7pt 0in .7pt;width:2.7%;">
  <p align="left" style="font-size:12.0pt;margin:0in 0in .0001pt;text-align:left;text-indent:0in;">&nbsp;</p>
  </td>
  <td width="82%" valign="top" style="border:none;padding:0in .7pt 0in .7pt;width:82.18%;">
  <p align="left" style="font-size:12.0pt;margin:0in 0in .0001pt;text-align:left;text-indent:0in;">&nbsp;</p>
  </td>
 </tr>
 <tr>
  <td width="15%" valign="top" style="border:none;padding:0in .7pt 0in .7pt;width:15.12%;">
  <p align="left" style="margin:0in 0in .0001pt 30.0pt;text-align:left;text-indent:0in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">4.2</font></p>
  </td>
  <td width="2%" valign="bottom" style="border:none;padding:0in .7pt 0in .7pt;width:2.7%;">
  <p align="left" style="font-size:1.0pt;margin:0in 0in .0001pt;text-align:left;text-indent:0in;">&nbsp;</p>
  </td>
  <td width="82%" valign="top" style="border:none;padding:0in .7pt 0in .7pt;width:82.18%;">
  <p align="left" style="margin:0in 0in .0001pt;text-align:left;text-indent:0in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">2000 Employee Stock Purchase Plan (incorporated by reference to
  Exhibit 10.6 of the Form&nbsp;S-1)</font></p>
  </td>
 </tr>
 <tr>
  <td width="15%" valign="top" style="border:none;padding:0in .7pt 0in .7pt;width:15.12%;">
  <p align="left" style="font-size:12.0pt;margin:0in 0in .0001pt 30.0pt;text-align:left;text-indent:0in;">&nbsp;</p>
  </td>
  <td width="2%" valign="bottom" style="border:none;padding:0in .7pt 0in .7pt;width:2.7%;">
  <p align="left" style="font-size:12.0pt;margin:0in 0in .0001pt;text-align:left;text-indent:0in;">&nbsp;</p>
  </td>
  <td width="82%" valign="top" style="border:none;padding:0in .7pt 0in .7pt;width:82.18%;">
  <p align="left" style="font-size:12.0pt;margin:0in 0in .0001pt;text-align:left;text-indent:0in;">&nbsp;</p>
  </td>
 </tr>
 <tr>
  <td width="15%" valign="top" style="border:none;padding:0in .7pt 0in .7pt;width:15.12%;">
  <p align="left" style="margin:0in 0in .0001pt 30.0pt;text-align:left;text-indent:0in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">5.1</font></p>
  </td>
  <td width="2%" valign="bottom" style="border:none;padding:0in .7pt 0in .7pt;width:2.7%;">
  <p align="left" style="font-size:1.0pt;margin:0in 0in .0001pt;text-align:left;text-indent:0in;">&nbsp;</p>
  </td>
  <td width="82%" valign="top" style="border:none;padding:0in .7pt 0in .7pt;width:82.18%;">
  <p align="left" style="margin:0in 0in .0001pt;text-align:left;text-indent:0in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">Opinion of Wilson Sonsini Goodrich &amp; Rosati, Professional
  Corporation, as to the legality of securities being registered</font></p>
  </td>
 </tr>
 <tr>
  <td width="15%" valign="top" style="border:none;padding:0in .7pt 0in .7pt;width:15.12%;">
  <p align="left" style="font-size:12.0pt;margin:0in 0in .0001pt 30.0pt;text-align:left;text-indent:0in;">&nbsp;</p>
  </td>
  <td width="2%" valign="bottom" style="border:none;padding:0in .7pt 0in .7pt;width:2.7%;">
  <p align="left" style="font-size:12.0pt;margin:0in 0in .0001pt;text-align:left;text-indent:0in;">&nbsp;</p>
  </td>
  <td width="82%" valign="top" style="border:none;padding:0in .7pt 0in .7pt;width:82.18%;">
  <p align="left" style="font-size:12.0pt;margin:0in 0in .0001pt;text-align:left;text-indent:0in;">&nbsp;</p>
  </td>
 </tr>
 <tr>
  <td width="15%" valign="top" style="border:none;padding:0in .7pt 0in .7pt;width:15.12%;">
  <p align="left" style="margin:0in 0in .0001pt 30.0pt;text-align:left;text-indent:0in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">23.1</font></p>
  </td>
  <td width="2%" valign="bottom" style="border:none;padding:0in .7pt 0in .7pt;width:2.7%;">
  <p align="left" style="font-size:1.0pt;margin:0in 0in .0001pt;text-align:left;text-indent:0in;">&nbsp;</p>
  </td>
  <td width="82%" valign="top" style="border:none;padding:0in .7pt 0in .7pt;width:82.18%;">
  <p align="left" style="margin:0in 0in .0001pt;text-align:left;text-indent:0in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">Consent of Wilson Sonsini Goodrich &amp; Rosati, Professional
  Corporation (contained in Exhibit 5.1 hereto)</font></p>
  </td>
 </tr>
 <tr>
  <td width="15%" valign="top" style="border:none;padding:0in .7pt 0in .7pt;width:15.12%;">
  <p align="left" style="font-size:12.0pt;margin:0in 0in .0001pt 30.0pt;text-align:left;text-indent:0in;">&nbsp;</p>
  </td>
  <td width="2%" valign="bottom" style="border:none;padding:0in .7pt 0in .7pt;width:2.7%;">
  <p align="left" style="font-size:12.0pt;margin:0in 0in .0001pt;text-align:left;text-indent:0in;">&nbsp;</p>
  </td>
  <td width="82%" valign="top" style="border:none;padding:0in .7pt 0in .7pt;width:82.18%;">
  <p align="left" style="font-size:12.0pt;margin:0in 0in .0001pt;text-align:left;text-indent:0in;">&nbsp;</p>
  </td>
 </tr>
 <tr>
  <td width="15%" valign="top" style="border:none;padding:0in .7pt 0in .7pt;width:15.12%;">
  <p align="left" style="margin:0in 0in .0001pt 30.0pt;text-align:left;text-indent:0in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">23.2</font></p>
  </td>
  <td width="2%" valign="bottom" style="border:none;padding:0in .7pt 0in .7pt;width:2.7%;">
  <p align="left" style="font-size:1.0pt;margin:0in 0in .0001pt;text-align:left;text-indent:0in;">&nbsp;</p>
  </td>
  <td width="82%" valign="top" style="border:none;padding:0in .7pt 0in .7pt;width:82.18%;">
  <p align="left" style="margin:0in 0in .0001pt;text-align:left;text-indent:0in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">Consent of PricewaterhouseCoopers LLP, Independent Accountants</font></p>
  </td>
 </tr>
 <tr>
  <td width="15%" valign="top" style="border:none;padding:0in .7pt 0in .7pt;width:15.12%;">
  <p align="left" style="font-size:12.0pt;margin:0in 0in .0001pt 30.0pt;text-align:left;text-indent:0in;">&nbsp;</p>
  </td>
  <td width="2%" valign="bottom" style="border:none;padding:0in .7pt 0in .7pt;width:2.7%;">
  <p align="left" style="font-size:12.0pt;margin:0in 0in .0001pt;text-align:left;text-indent:0in;">&nbsp;</p>
  </td>
  <td width="82%" valign="top" style="border:none;padding:0in .7pt 0in .7pt;width:82.18%;">
  <p align="left" style="font-size:12.0pt;margin:0in 0in .0001pt;text-align:left;text-indent:0in;">&nbsp;</p>
  </td>
 </tr>
 <tr>
  <td width="15%" valign="top" style="border:none;padding:0in .7pt 0in .7pt;width:15.12%;">
  <p align="left" style="margin:0in 0in .0001pt 30.0pt;text-align:left;text-indent:0in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">24.1</font></p>
  </td>
  <td width="2%" valign="bottom" style="border:none;padding:0in .7pt 0in .7pt;width:2.7%;">
  <p align="left" style="font-size:1.0pt;margin:0in 0in .0001pt;text-align:left;text-indent:0in;">&nbsp;</p>
  </td>
  <td width="82%" valign="top" style="border:none;padding:0in .7pt 0in .7pt;width:82.18%;">
  <p align="left" style="margin:0in 0in .0001pt;text-align:left;text-indent:0in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">Power of Attorney (see page II-4)</font></p>
  </td>
 </tr>
</table>

<p align="left" style="margin:0in 0in .0001pt;text-align:left;text-indent:0in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>

<p align="center" style="margin:0in 0in .0001pt;text-align:center;text-indent:0in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>


<div align="left" style="margin:0in 0in .0001pt;text-align:left;text-indent:0in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">

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[{"type": "S-8", "sequence": "1", "filename": "a2081659zs-8.htm", "description": "S-8", "secsgml_size_bytes": 93892}]
{"company-data": {"conformed-name": "CIPHERGEN BIOSYSTEMS INC", "cik": "0000926617", "assigned-sic": "8731", "irs-number": "330595156", "state-of-incorporation": "DE", "fiscal-year-end": "1231"}, "filing-values": {"form-type": "S-8", "act": "33", "file-number": "333-89834", "film-number": "02670943"}, "business-address": {"street1": "490 SAN ANTONIO RD", "street2": "STE 201", "city": "PALO ALTO", "state": "CA", "zip": "94306", "phone": "6504963770"}, "mail-address": {"street1": "490 SAN ANTONIO ROAD", "city": "PALO ALTO", "state": "CA", "zip": "94304"}, "former-company": {"former-conformed-name": "ABIOTIC SYSTEMS", "date-changed": "19950407"}}
As filed with the Securities and Exchange Commission on June
5, 2002
Registration No. 333-
SECURITIES AND
EXCHANGE COMMISSION
Washington, D.C. 20549
FORM S-8
REGISTRATION
STATEMENT
Under
The
Securities Act of 1933
CIPHERGEN BIOSYSTEMS, INC.
(Exact
  name of Registrant as specified in its charter)
Delaware
33-059-5156
(State
  or other jurisdiction of
incorporation
  or organization)
(I.R.S.
  Employer
Identification Number)
6611 Dumbarton
Circle
Fremont, CA 94555
(510) 505-2100
(Address, including zip
code, and telephone number, including area code, of Registrant's principal
executive offices)
2000 STOCK PLAN
2000 EMPLOYEE STOCK PURCHASE PLAN
(Full title of the Plans)
William E. Rich
President and Chief Executive Officer
Ciphergen Biosystems, Inc.
6611 Dumbarton Circle
Fremont, CA 94555
(510) 505-2100
(Name, address,
including zip code, and telephone number, including area code, of agent for
service)
Copies to:
Michael J. O'Donnell
Wilson Sonsini Goodrich & Rosati
Professional Corporation
650 Page Mill Road
Palo Alto, CA 94304
(650) 493-9300
CALCULATION OF
REGISTRATION FEE
Title of Each Class of
Securities to
be Registered
Amount
to be
Registered
Proposed
Maximum
Offering
Price
Per Share
Proposed
Maximum
Aggregate
Offering Price
Amount of
Registration Fee
2000
  Stock Plan
Common
  Stock,  $0.001 par value (1)
1,150,000
$
4.83
$
5,554,500
$
511.02
2000
  Employee Stock Purchase Plan
Common
Stock,  $0.001 par value
(currently
  outstanding options) (2)
150,000
$
4.10
$
615,000
$
56.58
Total Maximum
  Aggregate Offering Price
$
6,169,500
Total
  Registration Fees
$
567.60
(1)
The Proposed Maximum Offering Price Per
Share has been estimated in accordance with Rule 457(h) under the Securities
Act of 1933 solely for the purpose of calculating the registration fee.  No options have been granted with respect to
such shares.  The computation is based
upon the average of the high and low price of the Common Stock as reported on the
Nasdaq National Market on May 31, 2002, because the price at which the options
to be granted in the future may be exercised is not currently determinable.
(2)
The Proposed Maximum Offering Price Per
Share has been estimated in accordance with Rule 457(h) under the Securities
Act of 1933 solely for the purpose of calculating the registration fee.  The computation is based upon 85% (see
explanation in following sentence) of the average of the high and low price of
the Common Stock as reported on the Nasdaq National Market on May 31, 2002,
because the price at which the options to be granted in the future may be
exercised is not currently determinable. 
Pursuant to the Employee Stock Purchase Plan, which plan is incorporated
by reference herein, the Purchase Price of a share of Common Stock shall mean
an amount equal to 85% of the Fair Market Value of a share of Common Stock on
the Enrollment Date or the Exercise Date, whichever is lower.
CIPHERGEN BIOSYSTEMS,
INC.
REGISTRATION
STATEMENT ON FORM S-8
EXPLANATORY NOTE
The contents of
the Registration Statement No. 333-53530 on Form S-8 as filed with the
Securities and Exchange Commission (the "Commission") on January 11, 2001 and
May 21, 2001 are hereby incorporated herein by reference to the extent not replaced
hereby.
The
purpose of this Form S-8 is to register the following:
(i)
An additional
1,150,000 shares of Common Stock of Ciphergen Biosystems, Inc. (the
"Registrant") that are available for issuance under the 2000 Stock Plan, as
amended (the "Plan"), to reflect an additional 1,150,000 shares authorized for
issuance under the Plan by the Registrant's Board of Directors.
(ii)
An additional 150,000 shares of Common
Stock of Ciphergen Biosystems, Inc. (the "Registrant") that are available for
issuance under the 2000 Employee Stock Purchase Plan, as amended ("ESPP"), to
reflect an additional 150,000 shares authorized for issuance under the ESPP by
the Registrant's Board of Directors.
PART II
INFORMATION
REQUIRED IN THE REGISTRATION STATEMENT
Item 3.
Information Incorporated by
Reference
.
The following
documents and information previously filed with the Securities and Exchange
Commission are hereby incorporated herein by reference:
(a)
The Registrant's Annual Report filed on
Form 10-K (File No. 000-31617) for the fiscal year ended December 31,
2001.
(b)
The Registrant's proxy statement for the 2002 Annual
Meeting of Stockholders.
(c)
The Registrant's Quarterly Report filed on Form 10-Q
(File No. 000-31617) for the quarterly period ended March 31, 2002.
(d)
The description of the Common Stock of
the Registrant that is contained in the Registration Statement on Form 8-A
filed pursuant to Section 12 of the Securities Exchange Act of 1934 (the
"Exchange Act") on September 22, 2000.
(e)
All documents filed by the Registrant
pursuant to Sections 13(a), 13(c), 14 and 15(d) of the Exchange
Act subsequent to the filing of this Registration Statement and prior to the
filing of a post-effective amendment that indicates that all securities offered
have been sold or that deregisters all securities then remaining unsold, shall
be deemed to be incorporated by reference in this Registration Statement and to
be part hereof from the date of filing of such documents.
II-1
Item 8.
Exhibits
.
The Exhibits listed on
the accompanying Index to Exhibits are filed as part hereof, or incorporated by
reference into this Registration Statement. 
(See Exhibit Index below).
II-2
SIGNATURES
Pursuant to the
requirements of the Securities Act of 1933, the Registrant certifies that it
has reasonable grounds to believe that it meets all of the requirements for
filing on Form S-8 and has duly caused this Registration Statement to be
signed on its behalf by the undersigned, thereunto duly authorized in the City
of Fremont, State of California on May 31, 2002.
CIPHERGEN
  BIOSYSTEMS, INC.
By:
/s/ WILLIAM E. RICH
William E. Rich, Ph.D.
President and Chief Executive Officer
II-3
POWER
OF ATTORNEY
KNOW ALL PERSONS BY THESE
PRESENTS, that each person whose signature appears below constitutes and
appoints William E. Rich and Matthew J. Hogan, jointly and severally, his
or her attorney-in-fact, each with the power of substitution, for him in any
and all capacities, to sign any amendments to this Registration Statement on
Form S-8, and to file the same, with exhibits thereto and other documents
in connection therewith, with the Securities and Exchange Commission, hereby
ratifying and confirming all that each of said attorney-in-fact, or his
substitute or substitutes, may do or cause to be done by virtue hereof.
Pursuant to the
requirements of the Securities Act of 1933, this Registration Statement has
been signed by the following persons in the capacities and on the date
indicated.
SIGNATURE
TITLE
DATE
/s/ WILLIAM E. RICH
President and Chief Executive Officer (Principal Executive Officer)
June 4, 2002
William E. Rich
/s/ MATTHEW J. HOGAN
Vice President and Chief Financial Officer (Principal Financial
  Officer)
June 4, 2002
Matthew J. Hogan
/s/ DANIEL M. CASERZA
Corporate Controller (Principal Accounting Officer)
June 4, 2002
Daniel M. Caserza
/s/ JOHN A. YOUNG
Director
June 4, 2002
John A. Young
/s/ MICHAEL J. CALLAGHAN
Director
June 4, 2002
Michael J. Callaghan
/s/ WILLIAM R. GREEN
Director
June 4, 2002
William R. Green
/s/ JAMES L. RATHMANN
Director
June 4, 2002
James L. Rathmann
II-4
INDEX TO
EXHIBITS
Exhibit Number
Exhibit Document
4.1
2000 Stock Plan (incorporated by reference to Exhibit 10.5 of the
  Form S-1)
4.2
2000 Employee Stock Purchase Plan (incorporated by reference to
  Exhibit 10.6 of the Form S-1)
5.1
Opinion of Wilson Sonsini Goodrich & Rosati, Professional
  Corporation, as to the legality of securities being registered
23.1
Consent of Wilson Sonsini Goodrich & Rosati, Professional
  Corporation (contained in Exhibit 5.1 hereto)
23.2
Consent of PricewaterhouseCoopers LLP, Independent Accountants
24.1
Power of Attorney (see page II-4)