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<P ALIGN="CENTER"><FONT SIZE=2><B>As filed with the Securities and Exchange Commission on November&nbsp;19, 2001  </B></FONT></P>

<P ALIGN="RIGHT"><FONT SIZE=2><B> Registration No. 333-&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; </B></FONT></P>

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<P ALIGN="CENTER"><FONT SIZE=5><B>SECURITIES AND EXCHANGE COMMISSION<BR>  </B></FONT><FONT SIZE=2><B>Washington, D.C. 20549  </B></FONT></P>

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<P ALIGN="CENTER"><FONT SIZE=5><B>FORM S-8<BR>  </B></FONT><FONT SIZE=2><B>REGISTRATION STATEMENT<BR>
UNDER<BR>
THE SECURITIES ACT OF 1933  </B></FONT></P>

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<P ALIGN="CENTER"><FONT SIZE=5><B>OSTEX INTERNATIONAL,&nbsp;INC.<BR>  </B></FONT><FONT SIZE=2>(Exact name of registrant as specified in its charter) </FONT></P>

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<TD WIDTH="49%" ALIGN="CENTER"><FONT SIZE=2><B>Washington<BR> </B></FONT><FONT SIZE=2>(State of other jurisdiction of<BR>
incorporation or organization)</FONT></TD>
<TD WIDTH="2%"><FONT SIZE=2>&nbsp;</FONT></TD>
<TD WIDTH="49%" ALIGN="CENTER"><FONT SIZE=2><B>91-1450247<BR> </B></FONT><FONT SIZE=2>(I.R.S. Employer Identification No.)</FONT></TD>
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<P ALIGN="CENTER"><FONT SIZE=2><B>2203 Airport Way South, Suite 400<BR>
Seattle, Washington 98134<BR>  </B></FONT><FONT SIZE=2>(Address of principal executive offices, including zip code) </FONT></P>

<P ALIGN="CENTER"><FONT SIZE=2><B>OSTEX INTERNATIONAL,&nbsp;INC. AMENDED AND RESTATED 1994 STOCK OPTION PLAN<BR>  </B></FONT><FONT SIZE=2>(Full title of the plan) </FONT></P>

<P ALIGN="CENTER"><FONT SIZE=2><B>THOMAS A. BOLOGNA<BR>
Ostex International,&nbsp;Inc.<BR>
2203 Airport Way South, Suite 400<BR>
Seattle, Washington 98134<BR>
(206)&nbsp;292-8082<BR>  </B></FONT><FONT SIZE=2>(Name, address and telephone number, including area code, of agent for service) </FONT></P>

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<P ALIGN="CENTER"><FONT SIZE=2><B>Copy to:<BR>
JAMES R. LISBAKKEN<BR>
Perkins Coie LLP<BR>
1201 Third Avenue, Suite 4800<BR>
Seattle, Washington 98101-3099<BR>
(206)&nbsp;583-8888  </B></FONT></P>

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<P ALIGN="CENTER"><FONT SIZE=2><B> CALCULATION OF REGISTRATION FEE  </B></FONT></P>

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<TH WIDTH="33%" ALIGN="CENTER"><FONT SIZE=1><B>Title of Securities to be Registered</B></FONT><BR></TH>
<TH WIDTH="1%"><FONT SIZE=1>&nbsp;</FONT></TH>
<TH WIDTH="14%" ALIGN="CENTER"><FONT SIZE=1><B>Amount to Be<BR>
Registered(1)</B></FONT><BR></TH>
<TH WIDTH="1%"><FONT SIZE=1>&nbsp;</FONT></TH>
<TH WIDTH="19%" ALIGN="CENTER"><FONT SIZE=1><B>Proposed Maximum<BR>
Offering Price<BR>
Per Share(2)</B></FONT><BR></TH>
<TH WIDTH="1%"><FONT SIZE=1>&nbsp;</FONT></TH>
<TH WIDTH="14%" ALIGN="CENTER"><FONT SIZE=1><B>Proposed Maximum<BR>
Aggregate Offering Price(2)</B></FONT><BR></TH>
<TH WIDTH="1%"><FONT SIZE=1>&nbsp;</FONT></TH>
<TH WIDTH="18%" ALIGN="CENTER"><FONT SIZE=1><B>Amount of<BR>
Registration Fee(2)</B></FONT><BR></TH>
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<TD WIDTH="33%"><FONT SIZE=2>Common Stock, par value $0.01 per share</FONT></TD>
<TD WIDTH="1%"><FONT SIZE=2>&nbsp;</FONT></TD>
<TD WIDTH="14%" ALIGN="CENTER"><FONT SIZE=2>500,000</FONT></TD>
<TD WIDTH="1%"><FONT SIZE=2>&nbsp;</FONT></TD>
<TD WIDTH="19%" ALIGN="CENTER"><FONT SIZE=2>$1.84</FONT></TD>
<TD WIDTH="1%"><FONT SIZE=2>&nbsp;</FONT></TD>
<TD WIDTH="14%" ALIGN="CENTER"><FONT SIZE=2>$920,000</FONT></TD>
<TD WIDTH="1%"><FONT SIZE=2>&nbsp;</FONT></TD>
<TD WIDTH="18%" ALIGN="CENTER"><FONT SIZE=2>$230</FONT></TD>
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<DT><FONT SIZE=2>(1)</FONT></DT><DD><FONT SIZE=2>Together
with an indeterminate number of additional shares which may be necessary to adjust the number of shares reserved for issuance pursuant to such employee benefit plan as the
result of any future stock split, stock dividend or similar adjustment of Ostex International's outstanding common stock.
<BR><BR></FONT></DD><DT><FONT SIZE=2>(2)</FONT></DT><DD><FONT SIZE=2>Estimated
solely for the purpose of calculating the registration fee pursuant to Rule&nbsp;457(c) under the Securities Act of 1933, as amended. The calculation of the registration
fee is based upon a per share price of
$1.84, which was the average of the high ($1.91) and low ($1.76) sales prices of Ostex International's common stock on November&nbsp;16, 2001, as reported by the NASDAQ National Market. </FONT></DD></DL>
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<BR></FONT><FONT SIZE=2><B>PART II<BR>  <BR>    INFORMATION REQUIRED IN REGISTRATION STATEMENT    <BR>  </B></FONT></P>

<P><FONT SIZE=2><B>Item 3. INCORPORATION OF CERTAIN DOCUMENTS BY REFERENCE  </B></FONT></P>

<P><FONT SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;The following documents filed with the Securities and Exchange Commission (the "Commission") by Ostex International,&nbsp;Inc. (the "Registrant") are hereby
incorporated by reference in this Registration Statement: </FONT></P>


<P><FONT SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;(a)&nbsp;The
Registrant's Annual Report on Form&nbsp;10-K for the year ended December&nbsp;31, 2000, filed on March&nbsp;22, 2001, which contains audited
financial statements for the most recent fiscal year for which such statements have been filed. </FONT></P>

<P><FONT SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;(b)&nbsp;The
description of the Registrant's common stock contained in the Registrant's Registration Statement on Form&nbsp;8-A, filed on May&nbsp;6, 1996
under Section&nbsp;12(g) of the Securities Exchange Act of 1934, as amended (the "Exchange Act"), including any amendments or reports filed for the purpose of updating such description. </FONT></P>

<P><FONT SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;(c)&nbsp;All
other reports filed pursuant to Section&nbsp;13(a) or 15(d) of the Exchange Act since the end of the fiscal year covered by the Annual Report on
Form&nbsp;10-K referred to in (a)&nbsp;above. </FONT></P>

<P><FONT SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;All
documents filed by the Registrant pursuant to Sections 13(a), 13(c), 14 and 15(d) of the Exchange Act after the date hereof, and prior to the filing of a
post-effective amendment which indicates that the securities offered hereby have been sold or which deregisters the securities covered hereby then remaining unsold, shall also be deemed to
be incorporated by reference into this Registration Statement and to be a part hereof commencing on the respective dates on which such documents are filed. </FONT></P>


<P><FONT SIZE=2><B>Item 4. DESCRIPTION OF SECURITIES  </B></FONT></P>

<P><FONT SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;Not applicable. </FONT></P>

<P><FONT SIZE=2><B>Item 5. INTERESTS OF NAMED EXPERTS AND COUNSEL  </B></FONT></P>

<P><FONT SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;Not applicable. </FONT></P>

<P><FONT SIZE=2><B>Item 6. INDEMNIFICATION OF DIRECTORS AND OFFICERS  </B></FONT></P>

<P><FONT SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;Sections 23B.08.500 through 23B.08.600 of the Washington Business Corporation Act (the "WBCA") authorize a court to award, or a corporation's board of
directors to grant, indemnification to directors, officers, employees and agents of the Registrant and those serving at the Registrant's request in similar positions in any other corporation,
partnership, joint venture, trust or other enterprise in terms sufficiently broad to permit such indemnification under certain circumstances for liabilities (including reimbursement for expenses
incurred) arising under the Securities Act of 1933, as amended (the "Securities Act"). Article&nbsp;9 of the Registrant's Amended and Restated Articles of Incorporation provides for indemnification
of the Registrant's directors and officers, to the full extent permitted by applicable law as then in effect, against all expenses and liabilities (including any obligation to pay any judgment,
settlement, penalty, fine, including an excise tax assessed with respect to an employee benefit plan, or expense incurred with respect to the proceeding, including attorney's fees) actually and
reasonably incurred in connection with any threatened, pending or completed action, suit or proceeding, whether civil, criminal, administrative or investigative, and whether formal or informal, in
which the director or officer is, was or is threatened to be made a party to or is otherwise involved in by reason of the fact that the director or officer is or was a director or officer of the
Registrant, or, by reason of the fact that, while a director or officer of the Registrant, such director or officer is or was serving at the request of the Registrant as a director, officer, partner,
trustee, employee or agent of </FONT></P>

<P ALIGN="CENTER"><FONT SIZE=2>II&#150;1</FONT></P>

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<P><FONT SIZE=2>
another corporation or of a partnership, joint venture, trust, employee benefit plan or other enterprise. The director or officer will not be indemnified for any proceeding initiated by a director or
officer unless such proceeding was, prior to its initiation, authorized by the Registrant's Board of Directors or unless the proceeding is to enforce the rights of indemnification. No indemnity may be
provided by the Registrant for acts or omissions of an indemnified director finally adjudged to be intentional misconduct or a knowing violation of law, for conduct of such director finally adjudged
to be in violation of Section&nbsp;23B.08.310 of the WBCA, for any transaction with respect to which it was finally adjudged that such director personally received a benefit in money, property or
services to which the director was not legally entitled, or to the extent the corporation is otherwise prohibited by applicable law from paying such indemnification. </FONT></P>

<P><FONT SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;Section&nbsp;23B.08.320
of the WBCA authorizes a corporation to limit a director's liability to the corporation or its shareholders for monetary damages for acts or omissions as a
director, except in certain circumstances involving intentional misconduct, self-dealing or illegal corporate loans or distributions, or any transaction from which the director personally
receives a benefit in money, property or services to which the director is not legally entitled. Article&nbsp;8 of the Registrant's Amended and Restated Articles of Incorporation provides for
limitation of director liability to the maximum extent permitted by the WBCA. The Registrant also maintains an insurance policy insuring its directors and officers against liability for certain acts
or omissions while acting in their official capacity. </FONT></P>

<P><FONT SIZE=2><B>Item 7. EXEMPTION FROM REGISTRATION CLAIMED  </B></FONT></P>

<P><FONT SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;Not applicable. </FONT></P>

<P><FONT SIZE=2><B>Item 8. EXHIBITS  </B></FONT></P>

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<TH WIDTH="9%" ALIGN="LEFT"><FONT SIZE=1><B>Exhibit No.<BR> </B></FONT><HR NOSHADE></TH>
<TH WIDTH="3%"><FONT SIZE=1>&nbsp;</FONT></TH>
<TH WIDTH="89%" ALIGN="CENTER"><FONT SIZE=1><B>Description</B></FONT><HR NOSHADE></TH>
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5.1</FONT></TD>
<TD WIDTH="3%"><FONT SIZE=2><BR>&nbsp;</FONT></TD>
<TD WIDTH="89%"><FONT SIZE=2><BR>
Opinion of Perkins Coie LLP regarding legality of the common stock being registered</FONT></TD>
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23.1</FONT></TD>
<TD WIDTH="3%"><FONT SIZE=2><BR>&nbsp;</FONT></TD>
<TD WIDTH="89%"><FONT SIZE=2><BR>
Consent of Arthur Andersen LLP (Independent Accountants)</FONT></TD>
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23.2</FONT></TD>
<TD WIDTH="3%"><FONT SIZE=2><BR>&nbsp;</FONT></TD>
<TD WIDTH="89%"><FONT SIZE=2><BR>
Consent of Perkins Coie LLP (included in opinion filed as Exhibit 5.1)</FONT></TD>
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<TD WIDTH="9%" ALIGN="RIGHT"><FONT SIZE=2><BR>
24.1</FONT></TD>
<TD WIDTH="3%"><FONT SIZE=2><BR>&nbsp;</FONT></TD>
<TD WIDTH="89%"><FONT SIZE=2><BR>
Power of Attorney (see signature page)</FONT></TD>
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99.1</FONT></TD>
<TD WIDTH="3%"><FONT SIZE=2><BR>&nbsp;</FONT></TD>
<TD WIDTH="89%"><FONT SIZE=2><BR>
Ostex International, Inc. Amended and Restated 1994 Stock Option Plan (incorporated by reference to Appendix B of the Registrant's Proxy Statement on Schedule 14A filed on March 22, 2001).</FONT></TD>
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<P ALIGN="CENTER"><FONT SIZE=2>II&#150;2</FONT></P>

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<P><FONT SIZE=2><B>Item 9. UNDERTAKINGS  </B></FONT></P>

<P><FONT SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;A.&nbsp;&nbsp;The
undersigned Registrant hereby undertakes: </FONT></P>

<UL>

<P><FONT SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;(1)&nbsp;To
file, during any period in which offers or sales are being made, a post-effective amendment to this Registration Statement: </FONT></P>

<UL>
<UL>
<DL compact>
<DT><FONT SIZE=2>(i)</FONT></DT><DD><FONT SIZE=2>To
include any prospectus required by Section&nbsp;10(a)(3) of the Securities Act;
<BR><BR></FONT></DD><DT><FONT SIZE=2>(ii)</FONT></DT><DD><FONT SIZE=2>To
reflect in the prospectus any facts or events arising after the effective date of this Registration Statement (or the most recent
post-effective amendment thereof) which, individually or in the aggregate, represent a fundamental change in the information set forth in this Registration Statement; and
<BR><BR></FONT></DD><DT><FONT SIZE=2>(iii)</FONT></DT><DD><FONT SIZE=2>To
include any material information with respect to the plan of distribution not previously disclosed in this Registration Statement or any
material change to such information in this Registration Statement; </FONT></DD></DL>
</UL>
</UL>
</UL>
<UL>

<P><FONT SIZE=2><I>provided, however</I></FONT><FONT SIZE=2>, that paragraphs (1)(i)&nbsp;and (1)(ii)&nbsp;above do not apply if the information required to be included in a
post-effective amendment by those paragraphs is contained in periodic reports filed by the Registrant pursuant to Section&nbsp;13 or Section&nbsp;15(d) of the Exchange Act that are
incorporated by reference in this Registration Statement. </FONT></P>

<P><FONT SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;(2)&nbsp;That,
for the purpose of determining any liability under the Securities Act, each such post-effective amendment shall be deemed to be a new registration
statement relating to the securities offered therein, and the offering of such securities at that time shall be deemed to be the initial bona fide offering thereof. </FONT></P>

<P><FONT SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;(3)&nbsp;To
remove from registration by means of a post-effective amendment any of the securities being registered which remain unsold at the termination of the
offering. </FONT></P>

</UL>

<P><FONT SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;B.&nbsp;&nbsp;The
undersigned Registrant hereby undertakes that, for purposes of determining any liability under the Securities Act, each filing of the Registrant's annual report
pursuant to Section&nbsp;13(a) or 15(d) of the Exchange Act (and, where applicable, each filing of an employee benefits plan's annual report pursuant to Section&nbsp;15(d) of the Exchange Act)
that is incorporated by reference in this Registration Statement shall be deemed to be a new registration statement relating to the securities offered therein, and the offering of such securities at
that time shall be deemed to be the initial bona fide offering thereof. </FONT></P>

<P><FONT SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;C.&nbsp;&nbsp;Insofar
as indemnification for liabilities arising under the Securities Act may be permitted to directors, officers and controlling persons of the Registrant
pursuant to the foregoing provisions, or otherwise, the Registrant has been advised that in the opinion of the Commission such indemnification is against public policy as expressed in the Securities
Act and is, therefore, unenforceable. In the event that a claim for indemnification against such liabilities (other than the payment by the Registrant of expenses incurred or paid by a director,
officer or controlling person of the Registrant in the successful defense of any action, suit or proceeding) is asserted by such director, officer or controlling person in connection with the
securities being registered, the Registrant will, unless in the opinion of its counsel the matter has been settled by controlling precedent, submit to a court of appropriate jurisdiction the question
whether such indemnification by it is against public policy as expressed in the Securities Act and will be governed by the final adjudication of such issue. </FONT></P>

<P ALIGN="CENTER"><FONT SIZE=2>II&#150;3</FONT></P>

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<BR></FONT><FONT SIZE=2><B>SIGNATURES    <BR>  </B></FONT></P>

<P><FONT SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;Pursuant to the requirements of the Securities Act of 1933, as amended, the Registrant certifies that it has reasonable grounds to believe that it meets all of
the requirements for filing on Form&nbsp;S-8 and has duly caused this Registration Statement to be signed on its behalf by the undersigned, thereunto duly authorized, in the City of
Seattle, State of Washington, on the 14th day of November, 2001. </FONT></P>

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<TD COLSPAN=2><FONT SIZE=2><B>OSTEX INTERNATIONAL,&nbsp;INC.</B></FONT></TD>
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&nbsp;</FONT></TD>
<TD WIDTH="3%"><FONT SIZE=2><BR>&nbsp;</FONT></TD>
<TD WIDTH="5%"><FONT SIZE=2><BR>
By:</FONT></TD>
<TD WIDTH="46%"><FONT SIZE=2><BR>
/s/&nbsp;</FONT><FONT SIZE=2>THOMAS A. BOLOGNA</FONT><FONT SIZE=2>&nbsp;&nbsp;&nbsp;</FONT><HR NOSHADE><FONT SIZE=2> Thomas A. Bologna<BR></FONT> <FONT SIZE=2><I>Chairman of the Board of Directors,<BR>
President and Chief Executive Officer</I></FONT></TD>
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<BR></FONT><FONT SIZE=2><B>POWER OF ATTORNEY    <BR>  </B></FONT></P>

<P><FONT SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;Each person whose individual signature appears below hereby authorizes Thomas A. Bologna, as attorney-in-fact with full power of
substitution, to execute in the name and on the behalf of each person, individually and in each capacity stated below, and to file any and all amendments to this Registration Statement, including any
and all post-effective amendments. </FONT></P>

<P><FONT SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;Pursuant
to the requirements of the Securities Act of 1933, this Registration Statement has been signed by the following persons in the capacities indicated below on the
14<SUP>th</SUP> day of November, 2001. </FONT></P>

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<TH WIDTH="49%" ALIGN="CENTER"><FONT SIZE=1><B>Signature</B></FONT><HR NOSHADE></TH>
<TH WIDTH="3%"><FONT SIZE=1>&nbsp;</FONT></TH>
<TH WIDTH="49%" ALIGN="CENTER"><FONT SIZE=1><B>Title</B></FONT><HR NOSHADE></TH>
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<TD WIDTH="49%" ALIGN="CENTER"><FONT SIZE=2><BR>
/s/&nbsp;</FONT><FONT SIZE=2>THOMAS A. BOLOGNA</FONT><FONT SIZE=2>&nbsp;&nbsp;&nbsp;</FONT><HR NOSHADE><FONT SIZE=2> Thomas A. Bologna</FONT></TD>
<TD WIDTH="3%"><FONT SIZE=2><BR>&nbsp;</FONT></TD>
<TD WIDTH="49%" VALIGN="CENTER"><FONT SIZE=2><BR>
Chairman of the Board of Directors, President and Chief Executive Officer (Principal Executive, Financial and Accounting Officer)</FONT></TD>
</TR>
<TR VALIGN="BOTTOM">
<TD WIDTH="49%" ALIGN="CENTER"><FONT SIZE=2><BR>
/s/&nbsp;</FONT><FONT SIZE=2>THOMAS J. CABLE</FONT><FONT SIZE=2>&nbsp;&nbsp;&nbsp;</FONT><HR NOSHADE><FONT SIZE=2> Thomas J. Cable</FONT></TD>
<TD WIDTH="3%"><FONT SIZE=2><BR>&nbsp;</FONT></TD>
<TD WIDTH="49%" VALIGN="CENTER"><FONT SIZE=2><BR>
Director</FONT></TD>
</TR>
<TR VALIGN="BOTTOM">
<TD WIDTH="49%" ALIGN="CENTER"><FONT SIZE=2><BR>
/s/&nbsp;</FONT><FONT SIZE=2>ELISABETH L. EVANS</FONT><FONT SIZE=2>&nbsp;&nbsp;&nbsp;</FONT><HR NOSHADE><FONT SIZE=2> Elisabeth L. Evans, M.D.</FONT></TD>
<TD WIDTH="3%"><FONT SIZE=2><BR>&nbsp;</FONT></TD>
<TD WIDTH="49%" VALIGN="CENTER"><FONT SIZE=2><BR>
Director</FONT></TD>
</TR>
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<TD WIDTH="49%" ALIGN="CENTER"><FONT SIZE=2><BR>
/s/&nbsp;</FONT><FONT SIZE=2>DAVID R. EYRE</FONT><FONT SIZE=2>&nbsp;&nbsp;&nbsp;</FONT><HR NOSHADE><FONT SIZE=2> David R. Eyre, Ph.D</FONT></TD>
<TD WIDTH="3%"><FONT SIZE=2><BR>&nbsp;</FONT></TD>
<TD WIDTH="49%" VALIGN="CENTER"><FONT SIZE=2><BR>
Director</FONT></TD>
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<TD WIDTH="49%" ALIGN="CENTER"><FONT SIZE=2><BR>
/s/&nbsp;</FONT><FONT SIZE=2>FREDRIC J. FELDMAN</FONT><FONT SIZE=2>&nbsp;&nbsp;&nbsp;</FONT><HR NOSHADE><FONT SIZE=2> Fredric J. Feldman, Ph.D</FONT></TD>
<TD WIDTH="3%"><FONT SIZE=2><BR>&nbsp;</FONT></TD>
<TD WIDTH="49%" VALIGN="CENTER"><FONT SIZE=2><BR>
Director</FONT></TD>
</TR>
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<TD WIDTH="49%" ALIGN="CENTER"><FONT SIZE=2><BR>
/s/&nbsp;</FONT><FONT SIZE=2>JOHN H. TRIMMER</FONT><FONT SIZE=2>&nbsp;&nbsp;&nbsp;</FONT><HR NOSHADE><FONT SIZE=2> John H. Trimmer</FONT></TD>
<TD WIDTH="3%"><FONT SIZE=2><BR>&nbsp;</FONT></TD>
<TD WIDTH="49%" VALIGN="CENTER"><FONT SIZE=2><BR>
Director</FONT></TD>
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<P ALIGN="CENTER"><FONT SIZE=2>II&#150;4</FONT></P>

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<BR></FONT><FONT SIZE=2><B>INDEX TO EXHIBITS    <BR>  </B></FONT></P>

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<TH WIDTH="9%" ALIGN="LEFT"><FONT SIZE=1><B>Exhibit&nbsp;No.<BR> </B></FONT><HR NOSHADE></TH>
<TH WIDTH="3%"><FONT SIZE=1>&nbsp;</FONT></TH>
<TH WIDTH="89%" ALIGN="CENTER"><FONT SIZE=1><B>Description</B></FONT><HR NOSHADE></TH>
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5.1</FONT></TD>
<TD WIDTH="3%"><FONT SIZE=2><BR>&nbsp;</FONT></TD>
<TD WIDTH="89%"><FONT SIZE=2><BR>
Opinion of Perkins Coie LLP regarding legality of the common stock being registered</FONT></TD>
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23.1</FONT></TD>
<TD WIDTH="3%"><FONT SIZE=2><BR>&nbsp;</FONT></TD>
<TD WIDTH="89%"><FONT SIZE=2><BR>
Consent of Arthur Andersen LLP (Independent Accountants)</FONT></TD>
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23.2</FONT></TD>
<TD WIDTH="3%"><FONT SIZE=2><BR>&nbsp;</FONT></TD>
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Consent of Perkins Coie LLP (included in opinion filed as Exhibit 5.1)</FONT></TD>
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24.1</FONT></TD>
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Power of Attorney (see signature page)</FONT></TD>
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99.1</FONT></TD>
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<TD WIDTH="89%"><FONT SIZE=2><BR>
Ostex International, Inc. Amended and Restated 1994 Stock Option Plan (incorporated by reference to Appendix B of the Registrant's Proxy Statement on Schedule 14A filed on March 22, 2001)</FONT></TD>
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<FONT SIZE=2><A HREF="#toc_de1590_1">PART II INFORMATION REQUIRED IN REGISTRATION STATEMENT</A></FONT><BR>
<FONT SIZE=2><A HREF="#toc_de1590_2">SIGNATURES</A></FONT><BR>
<FONT SIZE=2><A HREF="#toc_de1590_3">POWER OF ATTORNEY</A></FONT><BR>
<FONT SIZE=2><A HREF="#toc_de1590_4">INDEX TO EXHIBITS</A></FONT><BR>

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[{"type": "S-8", "sequence": "1", "filename": "a2064098zs-8.htm", "description": "FORM S-8", "secsgml_size_bytes": 26419}]
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Prepared by MERRILL CORPORATION
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As filed with the Securities and Exchange Commission on November 19, 2001
Registration No. 333-
SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM S-8
REGISTRATION STATEMENT
UNDER
THE SECURITIES ACT OF 1933
OSTEX INTERNATIONAL, INC.
(Exact name of registrant as specified in its charter)
Washington
(State of other jurisdiction of
incorporation or organization)
91-1450247
(I.R.S. Employer Identification No.)
2203 Airport Way South, Suite 400
Seattle, Washington 98134
(Address of principal executive offices, including zip code)
OSTEX INTERNATIONAL, INC. AMENDED AND RESTATED 1994 STOCK OPTION PLAN
(Full title of the plan)
THOMAS A. BOLOGNA
Ostex International, Inc.
2203 Airport Way South, Suite 400
Seattle, Washington 98134
(206) 292-8082
(Name, address and telephone number, including area code, of agent for service)
Copy to:
JAMES R. LISBAKKEN
Perkins Coie LLP
1201 Third Avenue, Suite 4800
Seattle, Washington 98101-3099
(206) 583-8888
CALCULATION OF REGISTRATION FEE
Title of Securities to be Registered
Amount to Be
Registered(1)
Proposed Maximum
Offering Price
Per Share(2)
Proposed Maximum
Aggregate Offering Price(2)
Amount of
Registration Fee(2)
Common Stock, par value $0.01 per share
500,000
$1.84
$920,000
$230
(1)
Together
with an indeterminate number of additional shares which may be necessary to adjust the number of shares reserved for issuance pursuant to such employee benefit plan as the
result of any future stock split, stock dividend or similar adjustment of Ostex International's outstanding common stock.
(2)
Estimated
solely for the purpose of calculating the registration fee pursuant to Rule 457(c) under the Securities Act of 1933, as amended. The calculation of the registration
fee is based upon a per share price of
$1.84, which was the average of the high ($1.91) and low ($1.76) sales prices of Ostex International's common stock on November 16, 2001, as reported by the NASDAQ National Market.
PART II
INFORMATION REQUIRED IN REGISTRATION STATEMENT
Item 3. INCORPORATION OF CERTAIN DOCUMENTS BY REFERENCE
The following documents filed with the Securities and Exchange Commission (the "Commission") by Ostex International, Inc. (the "Registrant") are hereby
incorporated by reference in this Registration Statement:
(a) The
Registrant's Annual Report on Form 10-K for the year ended December 31, 2000, filed on March 22, 2001, which contains audited
financial statements for the most recent fiscal year for which such statements have been filed.
(b) The
description of the Registrant's common stock contained in the Registrant's Registration Statement on Form 8-A, filed on May 6, 1996
under Section 12(g) of the Securities Exchange Act of 1934, as amended (the "Exchange Act"), including any amendments or reports filed for the purpose of updating such description.
(c) All
other reports filed pursuant to Section 13(a) or 15(d) of the Exchange Act since the end of the fiscal year covered by the Annual Report on
Form 10-K referred to in (a) above.
All
documents filed by the Registrant pursuant to Sections 13(a), 13(c), 14 and 15(d) of the Exchange Act after the date hereof, and prior to the filing of a
post-effective amendment which indicates that the securities offered hereby have been sold or which deregisters the securities covered hereby then remaining unsold, shall also be deemed to
be incorporated by reference into this Registration Statement and to be a part hereof commencing on the respective dates on which such documents are filed.
Item 4. DESCRIPTION OF SECURITIES
Not applicable.
Item 5. INTERESTS OF NAMED EXPERTS AND COUNSEL
Not applicable.
Item 6. INDEMNIFICATION OF DIRECTORS AND OFFICERS
Sections 23B.08.500 through 23B.08.600 of the Washington Business Corporation Act (the "WBCA") authorize a court to award, or a corporation's board of
directors to grant, indemnification to directors, officers, employees and agents of the Registrant and those serving at the Registrant's request in similar positions in any other corporation,
partnership, joint venture, trust or other enterprise in terms sufficiently broad to permit such indemnification under certain circumstances for liabilities (including reimbursement for expenses
incurred) arising under the Securities Act of 1933, as amended (the "Securities Act"). Article 9 of the Registrant's Amended and Restated Articles of Incorporation provides for indemnification
of the Registrant's directors and officers, to the full extent permitted by applicable law as then in effect, against all expenses and liabilities (including any obligation to pay any judgment,
settlement, penalty, fine, including an excise tax assessed with respect to an employee benefit plan, or expense incurred with respect to the proceeding, including attorney's fees) actually and
reasonably incurred in connection with any threatened, pending or completed action, suit or proceeding, whether civil, criminal, administrative or investigative, and whether formal or informal, in
which the director or officer is, was or is threatened to be made a party to or is otherwise involved in by reason of the fact that the director or officer is or was a director or officer of the
Registrant, or, by reason of the fact that, while a director or officer of the Registrant, such director or officer is or was serving at the request of the Registrant as a director, officer, partner,
trustee, employee or agent of
II–1
another corporation or of a partnership, joint venture, trust, employee benefit plan or other enterprise. The director or officer will not be indemnified for any proceeding initiated by a director or
officer unless such proceeding was, prior to its initiation, authorized by the Registrant's Board of Directors or unless the proceeding is to enforce the rights of indemnification. No indemnity may be
provided by the Registrant for acts or omissions of an indemnified director finally adjudged to be intentional misconduct or a knowing violation of law, for conduct of such director finally adjudged
to be in violation of Section 23B.08.310 of the WBCA, for any transaction with respect to which it was finally adjudged that such director personally received a benefit in money, property or
services to which the director was not legally entitled, or to the extent the corporation is otherwise prohibited by applicable law from paying such indemnification.
Section 23B.08.320
of the WBCA authorizes a corporation to limit a director's liability to the corporation or its shareholders for monetary damages for acts or omissions as a
director, except in certain circumstances involving intentional misconduct, self-dealing or illegal corporate loans or distributions, or any transaction from which the director personally
receives a benefit in money, property or services to which the director is not legally entitled. Article 8 of the Registrant's Amended and Restated Articles of Incorporation provides for
limitation of director liability to the maximum extent permitted by the WBCA. The Registrant also maintains an insurance policy insuring its directors and officers against liability for certain acts
or omissions while acting in their official capacity.
Item 7. EXEMPTION FROM REGISTRATION CLAIMED
Not applicable.
Item 8. EXHIBITS
Exhibit No.
Description
5.1
Opinion of Perkins Coie LLP regarding legality of the common stock being registered
23.1
Consent of Arthur Andersen LLP (Independent Accountants)
23.2
Consent of Perkins Coie LLP (included in opinion filed as Exhibit 5.1)
24.1
Power of Attorney (see signature page)
99.1
Ostex International, Inc. Amended and Restated 1994 Stock Option Plan (incorporated by reference to Appendix B of the Registrant's Proxy Statement on Schedule 14A filed on March 22, 2001).
II–2
Item 9. UNDERTAKINGS
A.  The
undersigned Registrant hereby undertakes:
(1) To
file, during any period in which offers or sales are being made, a post-effective amendment to this Registration Statement:
(i)
To
include any prospectus required by Section 10(a)(3) of the Securities Act;
(ii)
To
reflect in the prospectus any facts or events arising after the effective date of this Registration Statement (or the most recent
post-effective amendment thereof) which, individually or in the aggregate, represent a fundamental change in the information set forth in this Registration Statement; and
(iii)
To
include any material information with respect to the plan of distribution not previously disclosed in this Registration Statement or any
material change to such information in this Registration Statement;
provided, however
, that paragraphs (1)(i) and (1)(ii) above do not apply if the information required to be included in a
post-effective amendment by those paragraphs is contained in periodic reports filed by the Registrant pursuant to Section 13 or Section 15(d) of the Exchange Act that are
incorporated by reference in this Registration Statement.
(2) That,
for the purpose of determining any liability under the Securities Act, each such post-effective amendment shall be deemed to be a new registration
statement relating to the securities offered therein, and the offering of such securities at that time shall be deemed to be the initial bona fide offering thereof.
(3) To
remove from registration by means of a post-effective amendment any of the securities being registered which remain unsold at the termination of the
offering.
B.  The
undersigned Registrant hereby undertakes that, for purposes of determining any liability under the Securities Act, each filing of the Registrant's annual report
pursuant to Section 13(a) or 15(d) of the Exchange Act (and, where applicable, each filing of an employee benefits plan's annual report pursuant to Section 15(d) of the Exchange Act)
that is incorporated by reference in this Registration Statement shall be deemed to be a new registration statement relating to the securities offered therein, and the offering of such securities at
that time shall be deemed to be the initial bona fide offering thereof.
C.  Insofar
as indemnification for liabilities arising under the Securities Act may be permitted to directors, officers and controlling persons of the Registrant
pursuant to the foregoing provisions, or otherwise, the Registrant has been advised that in the opinion of the Commission such indemnification is against public policy as expressed in the Securities
Act and is, therefore, unenforceable. In the event that a claim for indemnification against such liabilities (other than the payment by the Registrant of expenses incurred or paid by a director,
officer or controlling person of the Registrant in the successful defense of any action, suit or proceeding) is asserted by such director, officer or controlling person in connection with the
securities being registered, the Registrant will, unless in the opinion of its counsel the matter has been settled by controlling precedent, submit to a court of appropriate jurisdiction the question
whether such indemnification by it is against public policy as expressed in the Securities Act and will be governed by the final adjudication of such issue.
II–3
SIGNATURES
Pursuant to the requirements of the Securities Act of 1933, as amended, the Registrant certifies that it has reasonable grounds to believe that it meets all of
the requirements for filing on Form S-8 and has duly caused this Registration Statement to be signed on its behalf by the undersigned, thereunto duly authorized, in the City of
Seattle, State of Washington, on the 14th day of November, 2001.
OSTEX INTERNATIONAL, INC.
By:
/s/
THOMAS A. BOLOGNA
Thomas A. Bologna
Chairman of the Board of Directors,
President and Chief Executive Officer
POWER OF ATTORNEY
Each person whose individual signature appears below hereby authorizes Thomas A. Bologna, as attorney-in-fact with full power of
substitution, to execute in the name and on the behalf of each person, individually and in each capacity stated below, and to file any and all amendments to this Registration Statement, including any
and all post-effective amendments.
Pursuant
to the requirements of the Securities Act of 1933, this Registration Statement has been signed by the following persons in the capacities indicated below on the
14
th
day of November, 2001.
Signature
Title
/s/
THOMAS A. BOLOGNA
Thomas A. Bologna
Chairman of the Board of Directors, President and Chief Executive Officer (Principal Executive, Financial and Accounting Officer)
/s/
THOMAS J. CABLE
Thomas J. Cable
Director
/s/
ELISABETH L. EVANS
Elisabeth L. Evans, M.D.
Director
/s/
DAVID R. EYRE
David R. Eyre, Ph.D
Director
/s/
FREDRIC J. FELDMAN
Fredric J. Feldman, Ph.D
Director
/s/
JOHN H. TRIMMER
John H. Trimmer
Director
II–4
INDEX TO EXHIBITS
Exhibit No.
Description
5.1
Opinion of Perkins Coie LLP regarding legality of the common stock being registered
23.1
Consent of Arthur Andersen LLP (Independent Accountants)
23.2
Consent of Perkins Coie LLP (included in opinion filed as Exhibit 5.1)
24.1
Power of Attorney (see signature page)
99.1
Ostex International, Inc. Amended and Restated 1994 Stock Option Plan (incorporated by reference to Appendix B of the Registrant's Proxy Statement on Schedule 14A filed on March 22, 2001)
QuickLinks
PART II INFORMATION REQUIRED IN REGISTRATION STATEMENT
SIGNATURES
POWER OF ATTORNEY
INDEX TO EXHIBITS