As filed with the Securities and
Exchange Commission on May 31, 2000                       Registration No. 333-
================================================================================

                       SECURITIES AND EXCHANGE COMMISSION
                             WASHINGTON, D.C. 20549

                                    FORM S-8

                             REGISTRATION STATEMENT
                        UNDER THE SECURITIES ACT OF 1933

                       BIOJECT MEDICAL TECHNOLOGIES, INC.
             (Exact name of Registrant as specified in its charter)

           Oregon                                     93-1099680
-------------------------------             ------------------------------------
(State or other jurisdiction of             (I.R.S. Employer Identification No.)
Incorporation or organization)

                            7620 S.W. Bridgeport Road
                               Portland, OR 97224
                     --------------------------------------
                     Address of Principal Executive Offices

                                 (503) 639-7221
              ----------------------------------------------------
              (Registrant's Telephone Number, Including Area Code)

                   Bioject Inc. 401(k) Retirement Benefit Plan
          ------------------------------------------------------------
                            (Full Title of the Plan)

                                 James C. O'Shea
                             Chief Executive Officer
                            7620 S.W. Bridgeport Road
                             Portland, Oregon 97224
                        ---------------------------------------
                        (Name and Address of Agent For Service)

                                     (503) 639-7221
              ------------------------------------------------------------
             (Telephone Number, Including Area Code, of Agent For Service)

<TABLE>

                         CALCULATION OF REGISTRATION FEE

=================================================================================================================================
                                                                Proposed Maximum        Proposed Maximum
      Title of Each Class of               Amount to            Offering Price Per      Aggregate Offering         Amount of
   Securities to be Registered         be Registered(1)             Share(2)                  Price          Registration Fee(1)
---------------------------------------------------------------------------------------------------------------------------------
<S>                                     <C>                          <C>                    <C>                    <C>
Common Shares,                          20,000 shares                $8.6875                $173,750               $45.87
no par value
=================================================================================================================================
</TABLE>

(1)  To be offered by the Company pursuant to the Plan described herein.

(2)  The proposed maximum offering price per share and the registration fee were
     calculated in  accordance  with rule 457(c) and (h) based on the average of
     the high and low prices for shares of the registrant's  Common Stock on May
     23,  2000 as quoted by the Nasdaq  SmallCap  Market,  which was $8.6875 per
     share.

================================================================================

<PAGE>


           PART II. INFORMATION REQUIRED IN THE REGISTRATION STATEMENT

                      REGISTRATION OF ADDITIONAL SECURITIES

     Pursuant to General Instruction E, this Registration  Statement on Form S-8
is filed by Bioject Medical  Technologies,  Inc. (the  "Registrant") to register
additional securities under the Bioject Inc. 401(k) Retirement Benefit Plan (the
"Plan")  covered by the  Registrant's  Registration  Statement  on Form S-8 (No.
333-37017),  as amended. The additional  securities are to be issued pursuant to
an  amendment  to the Plan  approved by the  Registrant's  Board of Directors on
September  9,  1998.  Portions  of  Registration  Statement  No.  333-37017  are
incorporated herein by reference.


Item 8.  Exhibits.

Exhibit Number       Exhibit
--------------       -------
     4.1*            Bioject, Inc. 401(k) Retirement Benefit Plan

     5.1             Opinion of Dorsey & Whitney LLP

     5.2             Determination letter from the IRS with respect to
                     qualification of the Bioject, Inc. 401(k) Retirement
                     Benefit Plan under Section 401 of the Internal Revenue
                     Code of 1986, as amended

    23.1             Consent of Dorsey & Whitney LLP  (included in Exhibit 5.1)

    23.2             Consent of Independent Public Accountants

    24.1             Power of Attorney (See page II-6 of this Registration
                     Statement)
----------------------

*    Incorporated by reference to Exhibit 4.1 to the  Registrant's  Registration
     Statement on Form S-8 (No. 333-37017)











                                       2
<PAGE>

                                   SIGNATURES

     Pursuant to the  requirements of the Securities Act of 1933, the registrant
certifies  that it has  reasonable  grounds to believe  that it meets all of the
requirements  for  filing  on Form S-8 and has  duly  caused  this  registration
statement  to be  signed  on its  behalf  by  the  undersigned,  thereunto  duly
authorized, in the City of Portland, Oregon, on this 4th day of January, 2000.

                                    BIOJECT MEDICAL TECHNOLOGIES INC.


                                    By: /s/ James C. O'Shea
                                        ----------------------------------------
                                        James C. O'Shea
                                        Chairman of the Board, Chief Executive
                                          Officer and President








                                       3

<PAGE>

                                POWER OF ATTORNEY

     Each person whose signature appears below constitutes and appoints James C.
O'Shea and Chris  Farrell,  or either of them,  his  attorney-in-fact,  with the
power  of  substitution,  for  them  in any  and all  capacities,  to  sign  any
amendments to this registration  statement,  and to file the same, with exhibits
thereto and other  documents in connection  therewith,  with the  Securities and
Exchange   Commission,   hereby   ratifying   and   confirming   all  that  said
attorneys-in-fact,  or their  substitute or  substitutes,  may do or cause to be
done by virtue hereof.

     Pursuant  to  the   requirements  of  the  Securities  Act  of  1933,  this
registration  statement  has  been  signed  by  the  following  persons  in  the
capacities and on the date indicated.

Signature                    Title                            Date
---------                    -----                            ----


/s/ James C. O'Shea          Chairman of the Board            January 4, 2000
-----------------------      Chief Executive Officer
James C. O'Shea              and President (Principal
                             Executive, Accounting and
                             Financial Officer)


/s/ William A. Gouveia       Director                         January 7, 2000
-----------------------
William A. Gouveia


/s/ John Ruedy, M.D.         Director                         January 13, 2000
-----------------------
John Ruedy, M.D.


/s/ Grace Keeney Fey         Director                         January 6, 2000
-----------------------
Grace Keeney Fey


/s/ Eric T. Herfindal        Director                         January 6, 2000
-----------------------
Eric T. Herfindal


/s/ Richard J. Plestina      Director                         January 11, 2000
-----------------------
Richard J. Plestina


/s/ David H. de Weese        Director                         January 7, 2000
-----------------------
David H. de Weese


/s/ Edward Flynn             Director                         January 7, 2000
-----------------------
Edward Flynn


                                       4
<PAGE>


     Pursuant to the  requirements  of the  Securities Act of 1933, the trustees
(or other  persons who  administer  the employee  benefit plan) have duly caused
this  registration  statement  to be  signed on its  behalf by the  undersigned,
thereunto duly authorized, in the City of Portland,  Oregon, on this 31st day of
May, 2000.


                                        BIOJECT, INC.


                                        By:  /s/ Christine Farrell
                                             -----------------------------------
                                             Christine Farrell
                                             Secretary















                                       5
<PAGE>


                                  EXHIBIT INDEX

Exhibit
Number           Exhibit                                               Page
------           -------                                               ----

     4.1*            Bioject, Inc. 401(k) Retirement Benefit Plan

     5.1             Opinion of Dorsey & Whitney LLP

     5.2             Determination letter from the IRS with respect to
                     qualification of the Bioject, Inc. 401(k) Retirement
                     Benefit Plan under Section 401 of the Internal Revenue
                     Code of 1986, as amended

    23.1             Consent of Dorsey & Whitney LLP  (included in Exhibit 5.1)

    23.2             Consent of Independent Public Accountants

    24.1             Power of Attorney (See page II-6 of this Registration
                     Statement)
--------------------

*    Incorporated by reference to Exhibit 4.1 to the  Registrant's  Registration
     Statement on Form S-8 (No. 333-37017)
[{"type": "S-8", "sequence": "1", "filename": "0001.txt", "description": "REGISTRATION STATEMENT", "secsgml_size_bytes": 10041}]
{"company-data": {"conformed-name": "BIOJECT MEDICAL TECHNOLOGIES INC", "cik": "0000810084", "assigned-sic": "3841", "irs-number": "931099680", "state-of-incorporation": "OR", "fiscal-year-end": "0331"}, "filing-values": {"form-type": "S-8", "act": "33", "file-number": "333-38206", "film-number": "647209"}, "business-address": {"street1": "7620 S W BRIDGEPORT RD", "city": "PORTLAND", "state": "OR", "zip": "97224", "phone": "5036397221"}, "mail-address": {"street1": "7620 S W BRIDGEPORT ROAD", "city": "PORTLAND", "state": "OR", "zip": "97224"}, "former-company": {"former-conformed-name": "BIOJECT MEDICAL SYSTEMS LTD", "date-changed": "19920703"}}
As filed with the Securities and
Exchange Commission on May 31, 2000                       Registration No. 333-
================================================================================

                       SECURITIES AND EXCHANGE COMMISSION
                             WASHINGTON, D.C. 20549

                                    FORM S-8

                             REGISTRATION STATEMENT
                        UNDER THE SECURITIES ACT OF 1933

                       BIOJECT MEDICAL TECHNOLOGIES, INC.
             (Exact name of Registrant as specified in its charter)

           Oregon                                     93-1099680
-------------------------------             ------------------------------------
(State or other jurisdiction of             (I.R.S. Employer Identification No.)
Incorporation or organization)

                            7620 S.W. Bridgeport Road
                               Portland, OR 97224
                     --------------------------------------
                     Address of Principal Executive Offices

                                 (503) 639-7221
              ----------------------------------------------------
              (Registrant's Telephone Number, Including Area Code)

                   Bioject Inc. 401(k) Retirement Benefit Plan
          ------------------------------------------------------------
                            (Full Title of the Plan)

                                 James C. O'Shea
                             Chief Executive Officer
                            7620 S.W. Bridgeport Road
                             Portland, Oregon 97224
                        ---------------------------------------
                        (Name and Address of Agent For Service)

                                     (503) 639-7221
              ------------------------------------------------------------
             (Telephone Number, Including Area Code, of Agent For Service)

                         CALCULATION OF REGISTRATION FEE

=================================================================================================================================
                                                                Proposed Maximum        Proposed Maximum
      Title of Each Class of               Amount to            Offering Price Per      Aggregate Offering         Amount of
   Securities to be Registered         be Registered(1)             Share(2)                  Price          Registration Fee(1)
---------------------------------------------------------------------------------------------------------------------------------
Common Shares,                          20,000 shares                $8.6875                $173,750               $45.87
no par value
=================================================================================================================================
(1)  To be offered by the Company pursuant to the Plan described herein.

(2)  The proposed maximum offering price per share and the registration fee were
     calculated in  accordance  with rule 457(c) and (h) based on the average of
     the high and low prices for shares of the registrant's  Common Stock on May
     23,  2000 as quoted by the Nasdaq  SmallCap  Market,  which was $8.6875 per
     share.

================================================================================
PART II. INFORMATION REQUIRED IN THE REGISTRATION STATEMENT

                      REGISTRATION OF ADDITIONAL SECURITIES

     Pursuant to General Instruction E, this Registration  Statement on Form S-8
is filed by Bioject Medical  Technologies,  Inc. (the  "Registrant") to register
additional securities under the Bioject Inc. 401(k) Retirement Benefit Plan (the
"Plan")  covered by the  Registrant's  Registration  Statement  on Form S-8 (No.
333-37017),  as amended. The additional  securities are to be issued pursuant to
an  amendment  to the Plan  approved by the  Registrant's  Board of Directors on
September  9,  1998.  Portions  of  Registration  Statement  No.  333-37017  are
incorporated herein by reference.

Item 8.  Exhibits.

Exhibit Number       Exhibit
--------------       -------
     4.1*            Bioject, Inc. 401(k) Retirement Benefit Plan

     5.1             Opinion of Dorsey & Whitney LLP

     5.2             Determination letter from the IRS with respect to
                     qualification of the Bioject, Inc. 401(k) Retirement
                     Benefit Plan under Section 401 of the Internal Revenue
                     Code of 1986, as amended

    23.1             Consent of Dorsey & Whitney LLP  (included in Exhibit 5.1)

    23.2             Consent of Independent Public Accountants

    24.1             Power of Attorney (See page II-6 of this Registration
                     Statement)
----------------------

*    Incorporated by reference to Exhibit 4.1 to the  Registrant's  Registration
     Statement on Form S-8 (No. 333-37017)

                                       2
SIGNATURES

     Pursuant to the  requirements of the Securities Act of 1933, the registrant
certifies  that it has  reasonable  grounds to believe  that it meets all of the
requirements  for  filing  on Form S-8 and has  duly  caused  this  registration
statement  to be  signed  on its  behalf  by  the  undersigned,  thereunto  duly
authorized, in the City of Portland, Oregon, on this 4th day of January, 2000.

                                    BIOJECT MEDICAL TECHNOLOGIES INC.

                                    By: /s/ James C. O'Shea
                                        ----------------------------------------
                                        James C. O'Shea
                                        Chairman of the Board, Chief Executive
                                          Officer and President

                                       3
POWER OF ATTORNEY

     Each person whose signature appears below constitutes and appoints James C.
O'Shea and Chris  Farrell,  or either of them,  his  attorney-in-fact,  with the
power  of  substitution,  for  them  in any  and all  capacities,  to  sign  any
amendments to this registration  statement,  and to file the same, with exhibits
thereto and other  documents in connection  therewith,  with the  Securities and
Exchange   Commission,   hereby   ratifying   and   confirming   all  that  said
attorneys-in-fact,  or their  substitute or  substitutes,  may do or cause to be
done by virtue hereof.

     Pursuant  to  the   requirements  of  the  Securities  Act  of  1933,  this
registration  statement  has  been  signed  by  the  following  persons  in  the
capacities and on the date indicated.

Signature                    Title                            Date
---------                    -----                            ----

/s/ James C. O'Shea          Chairman of the Board            January 4, 2000
-----------------------      Chief Executive Officer
James C. O'Shea              and President (Principal
                             Executive, Accounting and
                             Financial Officer)

/s/ William A. Gouveia       Director                         January 7, 2000
-----------------------
William A. Gouveia

/s/ John Ruedy, M.D.         Director                         January 13, 2000
-----------------------
John Ruedy, M.D.

/s/ Grace Keeney Fey         Director                         January 6, 2000
-----------------------
Grace Keeney Fey

/s/ Eric T. Herfindal        Director                         January 6, 2000
-----------------------
Eric T. Herfindal

/s/ Richard J. Plestina      Director                         January 11, 2000
-----------------------
Richard J. Plestina

/s/ David H. de Weese        Director                         January 7, 2000
-----------------------
David H. de Weese

/s/ Edward Flynn             Director                         January 7, 2000
-----------------------
Edward Flynn

                                       4
Pursuant to the  requirements  of the  Securities Act of 1933, the trustees
(or other  persons who  administer  the employee  benefit plan) have duly caused
this  registration  statement  to be  signed on its  behalf by the  undersigned,
thereunto duly authorized, in the City of Portland,  Oregon, on this 31st day of
May, 2000.

                                        BIOJECT, INC.

                                        By:  /s/ Christine Farrell
                                             -----------------------------------
                                             Christine Farrell
                                             Secretary

                                       5
EXHIBIT INDEX

Exhibit
Number           Exhibit                                               Page
------           -------                                               ----

     4.1*            Bioject, Inc. 401(k) Retirement Benefit Plan

     5.1             Opinion of Dorsey & Whitney LLP

     5.2             Determination letter from the IRS with respect to
                     qualification of the Bioject, Inc. 401(k) Retirement
                     Benefit Plan under Section 401 of the Internal Revenue
                     Code of 1986, as amended

    23.1             Consent of Dorsey & Whitney LLP  (included in Exhibit 5.1)

    23.2             Consent of Independent Public Accountants

    24.1             Power of Attorney (See page II-6 of this Registration
                     Statement)
--------------------

*    Incorporated by reference to Exhibit 4.1 to the  Registrant's  Registration
     Statement on Form S-8 (No. 333-37017)