<HTML>
<HEAD>
<TITLE>S-8</TITLE>
</HEAD>
<BODY>



<H1 ALIGN=RIGHT><FONT FACE="Times New Roman, Times, Serif" SIZE=2>As filed with the Securities and Exchange
Commission on June 6, 2003<BR>Registration No. 333- </FONT></H1>

<H1 ALIGN=CENTER><FONT FACE="Times New Roman, Times, Serif" SIZE=2>SECURITIES
AND EXCHANGE COMMISSION</FONT></H1>

<H1 ALIGN=CENTER><FONT FACE="Times New Roman, Times, Serif" SIZE=2>Washington, D.C. 20549</FONT></H1><HR SIZE=1 WIDTH=20%><BR>
<H1 ALIGN=CENTER><FONT FACE="Times New Roman, Times, Serif" SIZE=4>FORM S-8<BR>REGISTRATION STATEMENT</FONT><BR>
<FONT FACE="Times New Roman, Times, Serif" SIZE=2><I>Under <BR>The Securities Act of 1933</I></FONT></H1><HR SIZE=1 WIDTH=20%>

<P ALIGN=CENTER><FONT FACE="Times New Roman, Times, Serif" SIZE=2><B>NEUROCRINE BIOSCIENCES, INC.</B><BR>
(Exact name of Registrant as specified in its charter)</FONT></P><HR SIZE=1 WIDTH=20%>

<TABLE WIDTH=100% CELLPADDING=0 CELLSPACING=0 BORDER=0 ALIGN=CENTER>
<TR>
<TD ALIGN=CENTER WIDTH=33%><FONT SIZE=2><B>Delaware</B></FONT><HR SIZE=1 WIDTH=55%></TD>
<TD ALIGN=CENTER WIDTH=34%><FONT SIZE=2>&nbsp;</FONT></TD>
<TD ALIGN=CENTER WIDTH=33%><FONT SIZE=2><B>33-0525145</B></FONT><HR SIZE=1 WIDTH=55%></TD>
</TR>

<TR>
<TD ALIGN=CENTER WIDTH=33%><FONT SIZE=2>(State of incorporation)</FONT></TD>
<TD ALIGN=CENTER WIDTH=34%><FONT SIZE=2>&nbsp;</FONT></TD>
<TD ALIGN=CENTER WIDTH=33%><FONT SIZE=2>(I.R.S. Employer Identification No.)</FONT></TD>
</TR>

</TABLE>


<P ALIGN=CENTER><FONT FACE="Times New Roman, Times, Serif" SIZE=2><B>10555
Science Center Drive<BR>San Diego, California 92121</B><BR>
(Address, including zip code, of principal executive offices)</FONT></P><HR SIZE=1 WIDTH=20%>

<P ALIGN=CENTER><FONT FACE="Times New Roman, Times, Serif" SIZE=2><B>NEUROCRINE
BIOSCIENCES, INC. 2003 INCENTIVE STOCK PLAN</B><BR>
(Full title of the plan)<BR></FONT></P><HR SIZE=1 WIDTH=20%>

<H1 ALIGN=CENTER><FONT FACE="Times New Roman, Times, Serif" SIZE=2>GARY A. LYONS<BR>
President, Chief Executive Officer<BR>
and Director<BR>
10555 Science Center Drive<BR>
San Diego, California 92121<BR>
(858) 658-7600</FONT></H1>

<P ALIGN=CENTER><FONT FACE="Times New Roman, Times, Serif" SIZE=2>(Name, address, and telephone number, including area code,
of agent for service)<BR>
</FONT></P><HR SIZE=1 WIDTH=20%>
<P ALIGN=CENTER><FONT FACE="Times New Roman, Times, Serif" SIZE=2><B><I>Copies to:</I><BR>
Scott N. Wolfe, Esq.<BR>
Latham &amp; Watkins <BR>
12636 High Bluff Drive, Suite 300<BR>
San Diego, California 92130<BR>
(858) 523-5400</B><BR>
</FONT></P><HR SIZE=1 WIDTH=20%>

<H1 ALIGN=CENTER><FONT FACE="Times New Roman, Times, Serif" SIZE=2>CALCULATION
OF REGISTRATION FEE</FONT></H1>



<HR>
<TABLE WIDTH=100% CELLPADDING=0 CELLSPACING=0 BORDER=0 ALIGN=CENTER>
<TR>
<TD ALIGN=CENTER WIDTH=25%><FONT SIZE=2><B>&nbsp;</B></FONT></TD>
<TD ALIGN=CENTER WIDTH=20%><FONT SIZE=2><B>&nbsp;</B></FONT></TD>
<TD ALIGN=CENTER WIDTH=19%><FONT SIZE=2><B>Proposed</B></FONT></TD>
<TD ALIGN=CENTER WIDTH=18%><FONT SIZE=2><B>Proposed</B></FONT></TD>
<TD ALIGN=CENTER WIDTH=19%><FONT SIZE=2><B>&nbsp;</B></FONT></TD>
</TR>

<TR>
<TD ALIGN=CENTER><FONT SIZE=2><B>&nbsp;</B></FONT></TD>
<TD ALIGN=CENTER><FONT SIZE=2><B>&nbsp;</B></FONT></TD>
<TD ALIGN=CENTER><FONT SIZE=2><B>Maximum</B></FONT></TD>
<TD ALIGN=CENTER><FONT SIZE=2><B>Maximum</B></FONT></TD>
<TD ALIGN=CENTER><FONT SIZE=2><B>&nbsp;</B></FONT></TD>
</TR>

<TR>
<TD ALIGN=CENTER><FONT SIZE=2><B>Title</B></FONT></TD>
<TD ALIGN=CENTER><FONT SIZE=2><B>Amount</B></FONT></TD>
<TD ALIGN=CENTER><FONT SIZE=2><B>Offering</B></FONT></TD>
<TD ALIGN=CENTER><FONT SIZE=2><B>Aggregate</B></FONT></TD>
<TD ALIGN=CENTER><FONT SIZE=2><B>Amount of</B></FONT></TD>
</TR>

<TR>
<TD ALIGN=CENTER><FONT SIZE=2><B>of Securities to</B></FONT></TD>
<TD ALIGN=CENTER><FONT SIZE=2><B>to be</B></FONT></TD>
<TD ALIGN=CENTER><FONT SIZE=2><B>Price</B></FONT></TD>
<TD ALIGN=CENTER><FONT SIZE=2><B>Offering</B></FONT></TD>
<TD ALIGN=CENTER><FONT SIZE=2><B>Registration</B></FONT></TD>
</TR>

<TR>
<TD ALIGN=CENTER><FONT SIZE=2><B>be Registered</B></FONT></TD>
<TD ALIGN=CENTER><FONT SIZE=2><B>Registered (1)</B></FONT></TD>
<TD ALIGN=CENTER><FONT SIZE=2><B>Per Share</B></FONT></TD>
<TD ALIGN=CENTER><FONT SIZE=2><B>Price</B></FONT></TD>
<TD ALIGN=CENTER><FONT SIZE=2><B>Fee</B></FONT></TD>
</TR>
</TABLE>
<HR>
<TABLE WIDTH=100% CELLPADDING=0 CELLSPACING=0 BORDER=0 ALIGN=CENTER>
<TR>
<TD WIDTH=25%><FONT SIZE=2>Common Stock</FONT></TD>
<TD WIDTH=20%><FONT SIZE=2><B>&nbsp;</B></FONT></TD>
<TD WIDTH=19%><FONT SIZE=2><B>&nbsp;</B></FONT></TD>
<TD WIDTH=18%><FONT SIZE=2><B>&nbsp;</B></FONT></TD>
<TD WIDTH=19%><FONT SIZE=2><B>&nbsp;</B></FONT></TD>
</TR>

<TR>
<TD><FONT SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;$0.001 par value (3)</FONT></TD>
<TD ALIGN=CENTER><FONT SIZE=2>1,087,500</FONT></TD>
<TD ALIGN=CENTER><FONT SIZE=2>(2)</FONT></TD>
<TD ALIGN=CENTER><FONT SIZE=2>$53,487,642</FONT></TD>
<TD ALIGN=CENTER><FONT SIZE=2>$4,921</FONT></TD>
</TR>
</TABLE>
<HR>
<OL TYPE=1>
<LI><FONT FACE="Times New Roman, Times, Serif" SIZE=2>Pursuant to Rule 416(a),  this Registration  Statement
shall also cover any additional shares of the Registrant&#146;s  common stock that become issuable under the plan
by reason of any stock dividend, stock split,  recapitalization or other similar transaction effected without
receipt of consideration that increases the number of the Registrant&#146;s outstanding shares of common stock.</FONT><BR><BR>

<LI><FONT FACE="Times New Roman, Times, Serif" SIZE=2>This  estimate is made  pursuant to Rule 457(h)  solely for purposes of  calculating
the registration  fee, and is  determined according to the following offering price  information:  of the 1,087,500 shares of common stock
reserved for issuance under the 2003 Plan being  registered  hereunder,  (i) 79,200 shares of common stock are subject to  outstanding
options with an exercise price of $43.17 per share,  (ii) 19,200  shares of common stock are subject to  outstanding  options  with an
exercise  price of $51.19 per share,  (iii)1,800  shares of common stock are subject to  outstanding  options with an exercise  price of
$50.70 per share,  (iv) 405,000 shares of common stock are subject to outstanding  options with an exercise price of $48.51 per share,  and
(v) 582,300  shares of common stock are reserved for issuance upon exercise of options to be granted in the future.  Pursuant to
Rule  457(h),  for all shares of common  stock being  registered  hereunder  with an exercise  price which  cannot be  presently
determined  (582,300),  the Proposed Maximum Offering Price Per Share, is $50.40 per share, which is the average of the high and
low sales prices of the  Registrant&#146;s  common stock as reported on the Nasdaq  National  Market on May 30, 2003.  The  remaining
12,500  shares of common  stock that were  reserved  for  issuance  under the 2003  Incentive  Stock  Plan have been  granted to
individuals as restricted stock grants and are not being registered hereunder.</FONT><BR><BR>

<LI><FONT FACE="Times New Roman, Times, Serif" SIZE=2>Each share of common  stock  includes a right to purchase  one
one-thousandth  of a share of Series A  Participating  preferred stock, par value $0.001 per share.</FONT></LI></OL>

<HR SIZE=4>


<H1 ALIGN=CENTER><FONT FACE="Times New Roman, Times, Serif" SIZE=2>PART I</FONT></H1>

<H1 ALIGN=CENTER><FONT FACE="Times New Roman, Times, Serif" SIZE=2>INFORMATION
REQUIRED IN THE SECTION 10 (a) PROSPECTUS</FONT></H1>

<H2 ALIGN=LEFT><FONT FACE="Times New Roman, Times, Serif" SIZE=2>Item 1. <U>Plan Information</U>.</FONT></H2>

<P><FONT FACE="Times New Roman, Times, Serif" SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Not required to be filed with
this Registration Statement.</FONT></P>

<H2 ALIGN=LEFT><FONT FACE="Times New Roman, Times, Serif" SIZE=2>Item 2.
<U>Registrant Information and Employee Plan Annual Information</U>.</FONT></H2>

<P><FONT FACE="Times New Roman, Times, Serif" SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Not required to be filed
with this Registration Statement.</FONT></P>
<BR>
<BR>


<H1 ALIGN=CENTER><FONT FACE="Times New Roman, Times, Serif" SIZE=2>PART II</FONT></H1>

<H1 ALIGN=CENTER><FONT FACE="Times New Roman, Times, Serif" SIZE=2>INFORMATION
REQUIRED IN THE REGISTRATION STATEMENT</FONT></H1>

<H1 ALIGN=LEFT><FONT FACE="Times New Roman, Times, Serif" SIZE=2>Item 3.
<U>Incorporation of Documents by Reference</U>.</FONT></H1>

<P><FONT FACE="Times New Roman, Times, Serif" SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;The following documents filed with
the Securities and Exchange Commission (the &#147;SEC&#148;) by Neurocrine
Biosciences, Inc. (the &#147;Company&#148;), are incorporated by reference in this Registration Statement.</FONT></P>

<OL TYPE=a>
<LI><FONT FACE="Times New Roman, Times, Serif" SIZE=2>The Company&#146;s Annual Report on Form 10-K for the year ended
December 31, 2002, filed March 4, 2003;</FONT><BR><BR>

<LI><FONT FACE="Times New Roman, Times, Serif" SIZE=2>The Company&#146;s Quarterly Report on Form 10-Q for the three months
ended March 31, 2003, filed May 2, 2003;</FONT><BR><BR>

<LI><FONT FACE="Times New Roman, Times, Serif" SIZE=2>The Company&#146;s Current Report on Form 8-K filed April 9, 2003;</FONT><BR><BR>

<LI><FONT FACE="Times New Roman, Times, Serif" SIZE=2>The Company&#146;s Current Report on Form 8-K filed June 3, 2003; and</FONT><BR><BR>

<LI><FONT FACE="Times New Roman, Times, Serif" SIZE=2>The description of the Company&#146;s Common Stock contained the Registration Statement on
Form 8-A filed on April 3, 1996.</FONT></LI></OL>

<P><FONT FACE="Times New Roman, Times, Serif" SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;All documents filed by the Company pursuant to
Sections 13(a), 13(c), 14 or 15(d) of the Securities Exchange Act of 1934, as amended (the &#147;Exchange Act&#148;), after the date of this
Registration Statement and prior to the filing of a post-effective amendment which indicates that all securities offered have been
sold or which deregisters all securities then remaining unsold, are incorporated by reference in this Registration Statement and are
a part hereof from the date of filing such documents.  Any statement contained in a document incorporated or deemed to be incorporated
by reference herein shall be deemed to be modified or superseded for purposes of this Registration Statement to the extent that a
statement contained herein or in any other subsequently filed document which also is or is deemed to be incorporated by reference
herein modifies or supersedes such statement.  Any such statement so modified or superseded shall not be deemed, except as so modified
or superseded, to constitute a part of this RegistrationStatement.</FONT></P>


<H1 ALIGN=LEFT><FONT FACE="Times New Roman, Times, Serif" SIZE=2>Item 4.
<U>Description of Securities</U>.</FONT></H1>

<P><FONT FACE="Times New Roman, Times, Serif" SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Not applicable.</FONT></P>

<H1 ALIGN=LEFT><FONT FACE="Times New Roman, Times, Serif" SIZE=2>Item 5. <U>Interests
of Named Experts and Counsel</U>.</FONT></H1>

<P><FONT FACE="Times New Roman, Times, Serif" SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Not applicable.</FONT></P>

<H2 ALIGN=LEFT><FONT FACE="Times New Roman, Times, Serif" SIZE=2>Item 6.
<U>Indemnification of Directors and Officers</U>.</FONT></H2>

<P><FONT FACE="Times New Roman, Times, Serif" SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;
Section 145 of the Delaware General Corporation Law generally allows the Company to indemnify directors and officers for
all expenses, judgments, fines and amounts in settlement actually paid and reasonably incurred in connection with any proceedings so
long as such party acted in good faith and in a manner reasonably believed to be in or not opposed to the Company&#146;s best interests
and, with respect to any criminal proceedings, if such party had no reasonable cause to believe his or her conduct to be unlawful.
Indemnification may only be made by the Company if the applicable standard of conduct set forth in Section 145 has been met by the
indemnified party upon a determination made (i) by the Board of Directors by a majority vote of the directors who are not parties to
such proceedings, even though less than a quorum, (ii) if there are no such directors, or if such directors so direct, by independent
legal counsel in a written opinion or (iii) by the stockholders.</FONT></P>

<P><FONT FACE="Times New Roman, Times, Serif" SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;
Article VII of the Company&#146;s Certificate of Incorporation and Article VI, Sections 6.1, 6.2 and 6.3 of the Company&#146;s
Bylaws provide for indemnification of its directors and officers, and permit indemnification of employees and other agents to the
maximum extent permitted by the Delaware General Corporation Law.  In addition, the Company has entered into indemnification
agreements with its officers and directors.</FONT></P>

<H1 ALIGN=LEFT><FONT FACE="Times New Roman, Times, Serif" SIZE=2>Item 7. <U>Exemption
From Registration Claimed</U>.</FONT></H1>

<P><FONT FACE="Times New Roman, Times, Serif" SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Not applicable.</FONT></P>

<H2 ALIGN=LEFT><FONT FACE="Times New Roman, Times, Serif" SIZE=2>Item 8.
<U>Exhibits</U>.</FONT></H2>

<P><FONT FACE="Times New Roman, Times, Serif" SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;
The following is a list of exhibits filed as part of this Registration Statement, which are incorporated
herein:</FONT></P>

<TABLE WIDTH=70% CELLPADDING=0 CELLSPACING=0 BORDER=0 ALIGN=CENTER>
<TR>
<TD WIDTH=20%><FONT SIZE=2>Exhibit</FONT></TD>
<TD WIDTH=50%><FONT SIZE=2>&nbsp;</FONT></TD>
</TR>

<TR>
<TD><FONT SIZE=2>Number</FONT><HR SIZE=1 WIDTH=45% ALIGN=LEFT></TD>
<TD><FONT SIZE=2>Document</FONT><HR SIZE=1 WIDTH=100% ALIGN=LEFT></TD>
</TR>
<TR>
<TD><FONT SIZE=2>&nbsp;&nbsp;4.1 (1)</FONT></TD>
<TD><FONT SIZE=2>Form of Common Stock Certificate</FONT></TD>
</TR>

<TR>
<TD><FONT SIZE=2>&nbsp;&nbsp;4.2*</FONT></TD>
<TD><FONT SIZE=2>Neurocrine Biosciences, Inc. 2003 Incentive Stock Plan</FONT></TD>
</TR>

<TR>
<TD><FONT SIZE=2>&nbsp;&nbsp;5.1*</FONT></TD>
<TD><FONT SIZE=2>Opinion of Latham &amp; Watkins LLP</FONT></TD>
</TR>

<TR>
<TD><FONT SIZE=2>23.1*</FONT></TD>
<TD><FONT SIZE=2>Consent of Ernst &amp; Young LLP, Independent Auditors</FONT></TD>
</TR>

<TR>
<TD><FONT SIZE=2>23.2*</FONT></TD>
<TD><FONT SIZE=2>Consent of Latham &amp; Watkins LLP (contained in Exhibit 5.1)</FONT></TD>
</TR>

<TR>
<TD><FONT SIZE=2>24.1*</FONT></TD>
<TD><FONT SIZE=2>Power of Attorney (included in the signature page of this Registration Statement)</FONT></TD>
</TR>
</TABLE>

<BR>
<BR>
<HR SIZE=1 WIDTH=15% ALIGN=LEFT><BR>
<P><FONT FACE="Times New Roman, Times, Serif" SIZE=2>*&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Filed herewith.
<BR>(1)&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Incorporated by reference to the Company's Registration Statement filed on
April 3, 1996 on Form S-1, as amended (File No. 333-03172).</FONT></P>
<H1 ALIGN=LEFT><FONT FACE="Times New Roman, Times, Serif" SIZE=2>Item 9. <U>Undertakings</U>.</FONT></H1>
<OL TYPE=a>

<LI><FONT FACE="Times New Roman, Times, Serif" SIZE=2>The undersigned Registrant hereby undertakes:</FONT><BR><BR>
<OL TYPE=1>
<LI><FONT FACE="Times New Roman, Times, Serif" SIZE=2>To file, during any period in which offers or sales are being made, a post-effective
amendment to this Registration Statement:</FONT><BR><BR>
<OL TYPE=i>
<LI><FONT FACE="Times New Roman, Times, Serif" SIZE=2>To include any prospectus required by Section 10(a)(3) of the Securities
         Act;</FONT><BR><BR>

<LI><FONT FACE="Times New Roman, Times, Serif" SIZE=2>To reflect in the prospectus any facts or events arising after
the effective date of this Registration Statement (or the most recent post-effective amendment thereof) which, individually or in the
aggregate, represent a fundamental change in the information set forth in this Registration Statement.
Notwithstanding the foregoing, any increase or decrease in volume of securities offered (if the total dollar value
of securities offered would not exceed that which was registered) and any deviation from the low or high and of the
estimated maximum offering range may be reflected in the form of prospectus filed with the SEC pursuant to Rule
424(b) if, in the aggregate, the changes in volume and price represent no more than 20 percent change in the maximum
aggregate offering price set forth in the &#147;Calculation of Registration Fee&#148; table in the effective Registration
Statement;
</FONT><BR><BR>

<LI><FONT FACE="Times New Roman, Times, Serif" SIZE=2>To include any material information with respect to the plan of distribution not
previously disclosed in this Registration Statement or any material change to such information in this Registration
Statement;</FONT></OL>

<P><FONT FACE="Times New Roman, Times, Serif" SIZE=2><I>provided, however</I>, that the undertakings set forth in paragraphs
(a)(1)(i) and (a)(1)(ii) above do not apply if the
Registration Statement is on Form S-3, Form S-8 or Form F-3, and the information required to be included in a post-effective
amendment by those paragraphs is contained in periodic reports filed with or furnished to the SEC by the Registrant pursuant
to Section 13 or 15(d) of the Exchange Act that are incorporated by reference in this Registration Statement.</FONT></P>

<LI><FONT FACE="Times New Roman, Times, Serif" SIZE=2>That, for the purpose of determining any liability under the Securities Act,
each such post-effective amendment shall be deemed to be a new registration statement relating to the securities offered therein,
and the offering of such securities at that time shall be deemed to be the initial bona fide offering thereof.</FONT><BR><BR>

<LI><FONT FACE="Times New Roman, Times, Serif" SIZE=2>To remove from registration by means of a post-effective amendment any of the
securities being registered which remain unsold at the termination of the offering.</FONT></OL><BR>

<LI><FONT FACE="Times New Roman, Times, Serif" SIZE=2>The undersigned Registrant hereby undertakes that, for purposes of determining
any liability under the Securities Act, each filing of the Registrant&#146;s annual report pursuant to Section 13(a) or 15(d) of the
Exchange Act (and, where applicable, each filing of an employee benefit plan&#146;s annual report pursuant to Section 15(d) of the
Exchange Act) that is incorporated by reference in this Registration Statement shall be deemed to be a new registration statement
relating to the securities offered therein, and the offering of such securities at that time shall be deemed to be the initial
bona fide offering thereof.</FONT><BR><BR>

<LI><FONT FACE="Times New Roman, Times, Serif" SIZE=2>Insofar as indemnification for liabilities arising under the Securities Act may
be permitted to directors, officers and controlling persons of the Registrant pursuant to the foregoing provisions, or otherwise, the
Registrant has been advised that in the opinion of the SEC such indemnification is against public policy as expressed in the Securities
Act and is, therefore, unenforceable.  In the event that a claim for indemnification against such liabilities (other than the payment
by the Registrant of expenses incurred or paid by a director, officer or controlling person of the Registrant in the successful
defense of any action, suit or proceeding) is asserted by such director, officer or controlling person in connection with the securities
being registered, the Registrant will, unless in the opinion of its counsel the matter has been settled by controlling precedent,
submit to a court of appropriate jurisdiction the question whether such indemnification by it is against public policy as expressed
in the Securities Act and will be governed by the final adjudication of such issue.
</FONT></OL>

<P ALIGN=CENTER><FONT FACE="Times New Roman, Times, Serif" SIZE=2><B>SIGNATURES</B></FONT></P>

<P><FONT FACE="Times New Roman, Times, Serif" SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Pursuant to the requirements of the Securities Act,
the Company certifies that it has reasonable grounds to believe that it meets all of the requirements for filing on Form S-8 and
has duly caused this Registration Statement to be signed on its behalf by the undersigned, thereunto duly authorized, in the
City of San Diego, State of California, on this sixth day of June 2003.</FONT></P>

<TABLE WIDTH=100% CELLPADDING=0 CELLSPACING=0 BORDER=0 ALIGN=CENTER>
<TR>
<TD WIDTH=50%><FONT SIZE=2>&nbsp;</FONT></TD>
<TD WIDTH=3%><FONT SIZE=2>&nbsp;</FONT></TD>
<TD WIDTH=47%><FONT SIZE=2>&nbsp;</FONT></TD>
</TR>

<TR>
<TD WIDTH=30%><FONT SIZE=2>&nbsp;</FONT></TD>
<TD COLSPAN=2><FONT SIZE=2>NEUROCRINE BIOSCIENCES, INC.</FONT></TD>
</TR>
<TR>
<TD WIDTH=30%><FONT SIZE=2>&nbsp;</FONT></TD>
<TD COLSPAN=2><FONT SIZE=2>&nbsp;</FONT></TD>
</TR>

<TR>
<TD WIDTH=30%><FONT SIZE=2>&nbsp;</FONT></TD>
<TD VALIGN=TOP><FONT SIZE=2>By:</FONT></TD>
<TD><FONT SIZE=2>/s/ Gary A. Lyons </FONT><HR SIZE=1 WIDTH=25% ALIGN=LEFT></TD>
</TR>


<TR>
<TD><FONT SIZE=2>&nbsp;</FONT></TD>
<TD><FONT SIZE=2>&nbsp;</FONT></TD>
<TD><FONT SIZE=2>Gary A. Lyons </FONT></TD>
</TR>

<TR>
<TD><FONT SIZE=2>&nbsp;</FONT></TD>
<TD><FONT SIZE=2>&nbsp;</FONT></TD>
<TD><FONT SIZE=2>President and Chief Executive Officer</FONT></TD>
</TR>
</TABLE>

<H1 ALIGN=CENTER><FONT FACE="Times New Roman, Times, Serif" SIZE=2>POWER OF ATTORNEY</FONT></H1>

<P><FONT FACE="Times New Roman, Times, Serif" SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;KNOW ALL PERSONS BY THESE PRESENTS,
that each such person whose signature appears below constitutes and appoints, jointly and severally, Gary A. Lyons and
Paul W. Hawran his attorneys-in-fact, each with the power of substitution, for him in any and all capacities, to sign
any amendments to this Registration Statement on Form S-8 (including post-effective amendments), and to file the same,
with all exhibits thereto, and other documents in connection therewith, with the SEC, hereby ratifying and confirming
all that each of said attorneys-in-fact, or his substitute or substitutes, may do or cause to be done by virtue hereof.</FONT></P>

<P><FONT FACE="Times New Roman, Times, Serif" SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<B>Pursuant to the requirements of the Securities
Act, this Registration Statement has been signed by the following persons in the capacities and on the dates indicated.</B></FONT></P>

<TABLE WIDTH=600 CELLPADDING=0 CELLSPACING=0 BORDER=0 ALIGN=CENTER>
<TR>
<TD WIDTH=30%><FONT SIZE=2>&nbsp;</FONT></TD>
<TD WIDTH=50%><FONT SIZE=2>&nbsp;</FONT></TD>
<TD WIDTH=20%><FONT SIZE=2>&nbsp;</FONT></TD>
</TR>

<TR>
<TD ALIGN=CENTER WIDTH=30%><FONT SIZE=2><B>Signature</B></FONT></TD>
<TD ALIGN=CENTER WIDTH=50%><FONT SIZE=2><B>Title</B></FONT></TD>
<TD ALIGN=CENTER WIDTH=20%><FONT SIZE=2><B>Date</B></FONT></TD>
</TR>

<TR>
<TD WIDTH=30%><FONT SIZE=2>&nbsp;</FONT></TD>
<TD WIDTH=40%><FONT SIZE=2>&nbsp;</FONT></TD>
<TD WIDTH=30%><FONT SIZE=2>&nbsp;</FONT></TD>
</TR>
<TR>
<TD WIDTH=30%><FONT SIZE=2>&nbsp;</FONT></TD>
<TD WIDTH=40%><FONT SIZE=2>&nbsp;</FONT></TD>
<TD WIDTH=30%><FONT SIZE=2>&nbsp;</FONT></TD>
</TR>

<TR VALIGN=TOP>
<TD WIDTH=30%><FONT SIZE=2>/s/ Gary A. Lyons</FONT><HR SIZE=1 WIDTH=90% ALIGN=LEFT></TD>
<TD WIDTH=40%><FONT SIZE=2>President, Chief Executive Officer and Director <BR>(Principal Executive Officer)</FONT></TD>
<TD WIDTH=30%><FONT SIZE=2>June 6, 2003</FONT></TD>
</TR>

<TR VALIGN=TOP>
<TD WIDTH=30%><FONT SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Gary A. Lyons</FONT></TD>
<TD WIDTH=40%><FONT SIZE=2>&nbsp;</FONT></TD>
<TD WIDTH=30%><FONT SIZE=2>&nbsp;</FONT></TD>
</TR>
<TR>
<TD WIDTH=30%><FONT SIZE=2>&nbsp;</FONT></TD>
<TD WIDTH=40%><FONT SIZE=2>&nbsp;</FONT></TD>
<TD WIDTH=30%><FONT SIZE=2>&nbsp;</FONT></TD>
</TR>
 <TR>
<TD WIDTH=30%><FONT SIZE=2>&nbsp;</FONT></TD>
<TD WIDTH=40%><FONT SIZE=2>&nbsp;</FONT></TD>
<TD WIDTH=30%><FONT SIZE=2>&nbsp;</FONT></TD>
</TR>

<TR VALIGN=TOP>
<TD WIDTH=30%><FONT SIZE=2>/s/ Paul W. Hawran</FONT><HR SIZE=1 WIDTH=90% ALIGN=LEFT></TD>
<TD WIDTH=40%><FONT SIZE=2>Executive Vice President and Chief Financial Officer (Principal Financial and Accounting Officer)</FONT></TD>
<TD WIDTH=30%><FONT SIZE=2>June 6, 2003</FONT></TD>
</TR>

<TR>
<TD WIDTH=30%><FONT SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Paul W. Hawran</FONT></TD>
<TD WIDTH=40%><FONT SIZE=2>&nbsp;</FONT></TD>
<TD WIDTH=30%><FONT SIZE=2>&nbsp;</FONT></TD>
</TR>
<TR>
<TD WIDTH=30%><FONT SIZE=2>&nbsp;</FONT></TD>
<TD WIDTH=40%><FONT SIZE=2>&nbsp;</FONT></TD>
<TD WIDTH=30%><FONT SIZE=2>&nbsp;</FONT></TD>
</TR>

<TR>
<TD WIDTH=30%><FONT SIZE=2>&nbsp;</FONT></TD>
<TD WIDTH=40%><FONT SIZE=2>&nbsp;</FONT></TD>
<TD WIDTH=30%><FONT SIZE=2>&nbsp;</FONT></TD>
</TR>

<TR VALIGN=TOP>
<TD WIDTH=30%><FONT SIZE=2>/s/ Joseph A. Mollica</FONT><HR SIZE=1 WIDTH=90% ALIGN=LEFT></TD>
<TD WIDTH=40%><FONT SIZE=2>Chairman of the Board of Directors</FONT></TD>
<TD WIDTH=30%><FONT SIZE=2>June 6, 2003</FONT></TD>
</TR>

<TR VALIGN=TOP>
<TD WIDTH=30%><FONT SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Joseph A. Mollica</FONT></TD>
<TD WIDTH=40%><FONT SIZE=2>&nbsp;</FONT></TD>
<TD WIDTH=30%><FONT SIZE=2>&nbsp;</FONT></TD>
</TR>
<TR>
<TD WIDTH=30%><FONT SIZE=2>&nbsp;</FONT></TD>
<TD WIDTH=40%><FONT SIZE=2>&nbsp;</FONT></TD>
<TD WIDTH=30%><FONT SIZE=2>&nbsp;</FONT></TD>
</TR>

<TR>
<TD WIDTH=30%><FONT SIZE=2>&nbsp;</FONT></TD>
<TD WIDTH=40%><FONT SIZE=2>&nbsp;</FONT></TD>
<TD WIDTH=30%><FONT SIZE=2>&nbsp;</FONT></TD>
</TR>
<TR VALIGN=TOP>
<TD WIDTH=30%><FONT SIZE=2>/s/ W. Thomas Mitchell</FONT><HR SIZE=1 WIDTH=90% ALIGN=LEFT></TD>
<TD WIDTH=40%><FONT SIZE=2>Director</FONT></TD>
<TD WIDTH=30%><FONT SIZE=2>June 6, 2003</FONT></TD>
</TR>

<TR VALIGN=TOP>
<TD WIDTH=30%><FONT SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;W. Thomas Mitchell</FONT></TD>
<TD WIDTH=40%><FONT SIZE=2>&nbsp;</FONT></TD>
<TD WIDTH=30%><FONT SIZE=2>&nbsp;</FONT></TD>
</TR>
<TR>
<TD WIDTH=30%><FONT SIZE=2>&nbsp;</FONT></TD>
<TD WIDTH=40%><FONT SIZE=2>&nbsp;</FONT></TD>
<TD WIDTH=30%><FONT SIZE=2>&nbsp;</FONT></TD>
</TR>

<TR>
<TD WIDTH=30%><FONT SIZE=2>&nbsp;</FONT></TD>
<TD WIDTH=40%><FONT SIZE=2>&nbsp;</FONT></TD>
<TD WIDTH=30%><FONT SIZE=2>&nbsp;</FONT></TD>
</TR>


<TR VALIGN=TOP>
<TD WIDTH=30%><FONT SIZE=2>/s/ Richard F. Pops</FONT><HR SIZE=1 WIDTH=90% ALIGN=LEFT></TD>
<TD WIDTH=40%><FONT SIZE=2>Director</FONT></TD>
<TD WIDTH=30%><FONT SIZE=2>June 6, 2003</FONT></TD>
</TR>

<TR VALIGN=TOP>
<TD WIDTH=30%><FONT SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Richard F. Pops</FONT></TD>
<TD WIDTH=40%><FONT SIZE=2>&nbsp;</FONT></TD>
<TD WIDTH=30%><FONT SIZE=2>&nbsp;</FONT></TD>
</TR>
<TR>
<TD WIDTH=30%><FONT SIZE=2>&nbsp;</FONT></TD>
<TD WIDTH=40%><FONT SIZE=2>&nbsp;</FONT></TD>
<TD WIDTH=30%><FONT SIZE=2>&nbsp;</FONT></TD>
</TR>

<TR>
<TD WIDTH=30%><FONT SIZE=2>&nbsp;</FONT></TD>
<TD WIDTH=40%><FONT SIZE=2>&nbsp;</FONT></TD>
<TD WIDTH=30%><FONT SIZE=2>&nbsp;</FONT></TD>
</TR>

<TR VALIGN=TOP>
<TD WIDTH=30%><FONT SIZE=2>/s/ Stephen A. Sherwin</FONT><HR SIZE=1 WIDTH=90% ALIGN=LEFT></TD>
<TD WIDTH=40%><FONT SIZE=2>Director</FONT></TD>
<TD WIDTH=30%><FONT SIZE=2>June 6, 2003</FONT></TD>
</TR>

<TR VALIGN=TOP>
<TD WIDTH=30%><FONT SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Stephen A. Sherwin</FONT></TD>
<TD WIDTH=40%><FONT SIZE=2>&nbsp;</FONT></TD>
<TD WIDTH=30%><FONT SIZE=2>&nbsp;</FONT></TD>
</TR>
<TR>
<TD WIDTH=30%><FONT SIZE=2>&nbsp;</FONT></TD>
<TD WIDTH=40%><FONT SIZE=2>&nbsp;</FONT></TD>
<TD WIDTH=30%><FONT SIZE=2>&nbsp;</FONT></TD>
</TR>

<TR>
<TD WIDTH=30%><FONT SIZE=2>&nbsp;</FONT></TD>
<TD WIDTH=40%><FONT SIZE=2>&nbsp;</FONT></TD>
<TD WIDTH=30%><FONT SIZE=2>&nbsp;</FONT></TD>
</TR>

<TR VALIGN=TOP>
<TD WIDTH=30%><FONT SIZE=2>/s/ Lawrence  Steinman</FONT><HR SIZE=1 WIDTH=90% ALIGN=LEFT></TD>
<TD WIDTH=40%><FONT SIZE=2>Director</FONT></TD>
<TD WIDTH=30%><FONT SIZE=2>June 6, 2003</FONT></TD>
</TR>

<TR VALIGN=TOP>
<TD WIDTH=30%><FONT SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Lawrence  Steinman</FONT></TD>
<TD WIDTH=40%><FONT SIZE=2>&nbsp;</FONT></TD>
<TD WIDTH=30%><FONT SIZE=2>&nbsp;</FONT></TD>
</TR>
<TR>
<TD WIDTH=30%><FONT SIZE=2>&nbsp;</FONT></TD>
<TD WIDTH=40%><FONT SIZE=2>&nbsp;</FONT></TD>
<TD WIDTH=30%><FONT SIZE=2>&nbsp;</FONT></TD>
</TR>

<TR>
<TD WIDTH=30%><FONT SIZE=2>&nbsp;</FONT></TD>
<TD WIDTH=40%><FONT SIZE=2>&nbsp;</FONT></TD>
<TD WIDTH=30%><FONT SIZE=2>&nbsp;</FONT></TD>
</TR>

<TR VALIGN=TOP>
<TD WIDTH=30%><FONT SIZE=2>/s/ Wylie W. Vale</FONT><HR SIZE=1 WIDTH=90% ALIGN=LEFT></TD>
<TD WIDTH=40%><FONT SIZE=2>Director</FONT></TD>
<TD WIDTH=30%><FONT SIZE=2>June 6, 2003</FONT></TD>
</TR>

<TR VALIGN=TOP>
<TD WIDTH=30%><FONT SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Wylie W. Vale</FONT></TD>
<TD WIDTH=40%><FONT SIZE=2>&nbsp;</FONT></TD>
<TD WIDTH=30%><FONT SIZE=2>&nbsp;</FONT></TD>
</TR>

<TR>
<TD WIDTH=30%><FONT SIZE=2>&nbsp;</FONT></TD>
<TD WIDTH=40%><FONT SIZE=2>&nbsp;</FONT></TD>
<TD WIDTH=30%><FONT SIZE=2>&nbsp;</FONT></TD>
</TR>

</TABLE>



<H1 ALIGN=CENTER><FONT FACE="Times New Roman, Times, Serif" SIZE=2>INDEX TO EXHIBITS</FONT></H1>
<TABLE WIDTH=70% CELLPADDING=0 CELLSPACING=0 BORDER=0 ALIGN=CENTER>
<TR>
<TD WIDTH=20%><FONT SIZE=2>Exhibit</FONT></TD>
<TD WIDTH=50%><FONT SIZE=2>&nbsp;</FONT></TD>
</TR>

<TR>
<TD><FONT SIZE=2>Number</FONT><HR SIZE=1 WIDTH=45% ALIGN=LEFT></TD>
<TD><FONT SIZE=2>Document</FONT><HR SIZE=1 WIDTH=100% ALIGN=LEFT></TD>
</TR>

<TR>
<TD><FONT SIZE=2>&nbsp;&nbsp;4.1 (1)</FONT></TD>
<TD><FONT SIZE=2>Form of Common Stock Certificate</FONT></TD>
</TR>

<TR>
<TD><FONT SIZE=2>&nbsp;&nbsp;4.2*</FONT></TD>
<TD><FONT SIZE=2>Neurocrine Biosciences, Inc. 2003 Incentive Stock Plan</FONT></TD>
</TR>

<TR>
<TD><FONT SIZE=2>&nbsp;&nbsp;5.1*</FONT></TD>
<TD><FONT SIZE=2>Opinion of Latham &amp; Watkins LLP</FONT></TD>
</TR>

<TR>
<TD><FONT SIZE=2>23.1*</FONT></TD>
<TD><FONT SIZE=2>Consent of Ernst &amp; Young LLP, Independent Auditors</FONT></TD>
</TR>

<TR>
<TD><FONT SIZE=2>23.2*</FONT></TD>
<TD><FONT SIZE=2>Consent of Latham &amp; Watkins LLP (contained in Exhibit 5.1)</FONT></TD>
</TR>

<TR>
<TD><FONT SIZE=2>24.1*</FONT></TD>
<TD><FONT SIZE=2>Power of Attorney (included in the signature page of this Registration Statement)</FONT></TD>
</TR>
</TABLE>
<BR>
<BR>
<HR SIZE=1 WIDTH=15% ALIGN=LEFT><BR>
<P><FONT FACE="Times New Roman, Times, Serif" SIZE=2>*&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Filed herewith.<BR>(1)&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Incorporated by reference to the Company's Registration Statement filed on April 3, 1996 on Form S-1, as
         amended (File No. 333-03172).</FONT></P>


</BODY>
</HTML>
[{"type": "S-8", "sequence": "1", "filename": "s8.htm", "description": "FORM S-8", "secsgml_size_bytes": 30596}]
{"company-data": {"conformed-name": "NEUROCRINE BIOSCIENCES INC", "cik": "0000914475", "assigned-sic": "2836", "irs-number": "330525145", "state-of-incorporation": "CA", "fiscal-year-end": "1231"}, "filing-values": {"form-type": "S-8", "act": "33", "file-number": "333-105907", "film-number": "03735609"}, "business-address": {"street1": "10555 SCIENCE CENTER DRIVE", "city": "SAN DIEGO", "state": "CA", "zip": "92121", "phone": "8586587600"}, "mail-address": {"street1": "10555 SCIENCE CENTER DRIVE", "city": "SAN DIEGO", "state": "CA", "zip": "92121"}}
S-8
As filed with the Securities and Exchange
Commission on June 6, 2003
Registration No. 333-
SECURITIES
AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM S-8
REGISTRATION STATEMENT
Under
The Securities Act of 1933
NEUROCRINE BIOSCIENCES, INC.
(Exact name of Registrant as specified in its charter)
Delaware
33-0525145
(State of incorporation)
(I.R.S. Employer Identification No.)
10555
Science Center Drive
San Diego, California 92121
(Address, including zip code, of principal executive offices)
NEUROCRINE
BIOSCIENCES, INC. 2003 INCENTIVE STOCK PLAN
(Full title of the plan)
GARY A. LYONS
President, Chief Executive Officer
and Director
10555 Science Center Drive
San Diego, California 92121
(858) 658-7600
(Name, address, and telephone number, including area code,
of agent for service)
Copies to:
Scott N. Wolfe, Esq.
Latham & Watkins
12636 High Bluff Drive, Suite 300
San Diego, California 92130
(858) 523-5400
CALCULATION
OF REGISTRATION FEE
Proposed
Proposed
Maximum
Maximum
Title
Amount
Offering
Aggregate
Amount of
of Securities to
to be
Price
Offering
Registration
be Registered
Registered (1)
Per Share
Price
Fee
Common Stock
$0.001 par value (3)
1,087,500
(2)
$53,487,642
$4,921
Pursuant to Rule 416(a),  this Registration  Statement
shall also cover any additional shares of the Registrant's  common stock that become issuable under the plan
by reason of any stock dividend, stock split,  recapitalization or other similar transaction effected without
receipt of consideration that increases the number of the Registrant's outstanding shares of common stock.
This  estimate is made  pursuant to Rule 457(h)  solely for purposes of  calculating
the registration  fee, and is  determined according to the following offering price  information:  of the 1,087,500 shares of common stock
reserved for issuance under the 2003 Plan being  registered  hereunder,  (i) 79,200 shares of common stock are subject to  outstanding
options with an exercise price of $43.17 per share,  (ii) 19,200  shares of common stock are subject to  outstanding  options  with an
exercise  price of $51.19 per share,  (iii)1,800  shares of common stock are subject to  outstanding  options with an exercise  price of
$50.70 per share,  (iv) 405,000 shares of common stock are subject to outstanding  options with an exercise price of $48.51 per share,  and
(v) 582,300  shares of common stock are reserved for issuance upon exercise of options to be granted in the future.  Pursuant to
Rule  457(h),  for all shares of common  stock being  registered  hereunder  with an exercise  price which  cannot be  presently
determined  (582,300),  the Proposed Maximum Offering Price Per Share, is $50.40 per share, which is the average of the high and
low sales prices of the  Registrant's  common stock as reported on the Nasdaq  National  Market on May 30, 2003.  The  remaining
12,500  shares of common  stock that were  reserved  for  issuance  under the 2003  Incentive  Stock  Plan have been  granted to
individuals as restricted stock grants and are not being registered hereunder.
Each share of common  stock  includes a right to purchase  one
one-thousandth  of a share of Series A  Participating  preferred stock, par value $0.001 per share.
PART I
INFORMATION
REQUIRED IN THE SECTION 10 (a) PROSPECTUS
Item 1.
Plan Information
.
Not required to be filed with
this Registration Statement.
Item 2.
Registrant Information and Employee Plan Annual Information
.
Not required to be filed
with this Registration Statement.
PART II
INFORMATION
REQUIRED IN THE REGISTRATION STATEMENT
Item 3.
Incorporation of Documents by Reference
.
The following documents filed with
the Securities and Exchange Commission (the "SEC") by Neurocrine
Biosciences, Inc. (the "Company"), are incorporated by reference in this Registration Statement.
The Company's Annual Report on Form 10-K for the year ended
December 31, 2002, filed March 4, 2003;
The Company's Quarterly Report on Form 10-Q for the three months
ended March 31, 2003, filed May 2, 2003;
The Company's Current Report on Form 8-K filed April 9, 2003;
The Company's Current Report on Form 8-K filed June 3, 2003; and
The description of the Company's Common Stock contained the Registration Statement on
Form 8-A filed on April 3, 1996.
All documents filed by the Company pursuant to
Sections 13(a), 13(c), 14 or 15(d) of the Securities Exchange Act of 1934, as amended (the "Exchange Act"), after the date of this
Registration Statement and prior to the filing of a post-effective amendment which indicates that all securities offered have been
sold or which deregisters all securities then remaining unsold, are incorporated by reference in this Registration Statement and are
a part hereof from the date of filing such documents.  Any statement contained in a document incorporated or deemed to be incorporated
by reference herein shall be deemed to be modified or superseded for purposes of this Registration Statement to the extent that a
statement contained herein or in any other subsequently filed document which also is or is deemed to be incorporated by reference
herein modifies or supersedes such statement.  Any such statement so modified or superseded shall not be deemed, except as so modified
or superseded, to constitute a part of this RegistrationStatement.
Item 4.
Description of Securities
.
Not applicable.
Item 5.
Interests
of Named Experts and Counsel
.
Not applicable.
Item 6.
Indemnification of Directors and Officers
.
Section 145 of the Delaware General Corporation Law generally allows the Company to indemnify directors and officers for
all expenses, judgments, fines and amounts in settlement actually paid and reasonably incurred in connection with any proceedings so
long as such party acted in good faith and in a manner reasonably believed to be in or not opposed to the Company's best interests
and, with respect to any criminal proceedings, if such party had no reasonable cause to believe his or her conduct to be unlawful.
Indemnification may only be made by the Company if the applicable standard of conduct set forth in Section 145 has been met by the
indemnified party upon a determination made (i) by the Board of Directors by a majority vote of the directors who are not parties to
such proceedings, even though less than a quorum, (ii) if there are no such directors, or if such directors so direct, by independent
legal counsel in a written opinion or (iii) by the stockholders.
Article VII of the Company's Certificate of Incorporation and Article VI, Sections 6.1, 6.2 and 6.3 of the Company's
Bylaws provide for indemnification of its directors and officers, and permit indemnification of employees and other agents to the
maximum extent permitted by the Delaware General Corporation Law.  In addition, the Company has entered into indemnification
agreements with its officers and directors.
Item 7.
Exemption
From Registration Claimed
.
Not applicable.
Item 8.
Exhibits
.
The following is a list of exhibits filed as part of this Registration Statement, which are incorporated
herein:
Exhibit
Number
Document
4.1 (1)
Form of Common Stock Certificate
4.2*
Neurocrine Biosciences, Inc. 2003 Incentive Stock Plan
5.1*
Opinion of Latham & Watkins LLP
23.1*
Consent of Ernst & Young LLP, Independent Auditors
23.2*
Consent of Latham & Watkins LLP (contained in Exhibit 5.1)
24.1*
Power of Attorney (included in the signature page of this Registration Statement)
*       Filed herewith.
(1)     Incorporated by reference to the Company's Registration Statement filed on
April 3, 1996 on Form S-1, as amended (File No. 333-03172).
Item 9.
Undertakings
.
The undersigned Registrant hereby undertakes:
To file, during any period in which offers or sales are being made, a post-effective
amendment to this Registration Statement:
To include any prospectus required by Section 10(a)(3) of the Securities
         Act;
To reflect in the prospectus any facts or events arising after
the effective date of this Registration Statement (or the most recent post-effective amendment thereof) which, individually or in the
aggregate, represent a fundamental change in the information set forth in this Registration Statement.
Notwithstanding the foregoing, any increase or decrease in volume of securities offered (if the total dollar value
of securities offered would not exceed that which was registered) and any deviation from the low or high and of the
estimated maximum offering range may be reflected in the form of prospectus filed with the SEC pursuant to Rule
424(b) if, in the aggregate, the changes in volume and price represent no more than 20 percent change in the maximum
aggregate offering price set forth in the "Calculation of Registration Fee" table in the effective Registration
Statement;
To include any material information with respect to the plan of distribution not
previously disclosed in this Registration Statement or any material change to such information in this Registration
Statement;
provided, however
, that the undertakings set forth in paragraphs
(a)(1)(i) and (a)(1)(ii) above do not apply if the
Registration Statement is on Form S-3, Form S-8 or Form F-3, and the information required to be included in a post-effective
amendment by those paragraphs is contained in periodic reports filed with or furnished to the SEC by the Registrant pursuant
to Section 13 or 15(d) of the Exchange Act that are incorporated by reference in this Registration Statement.
That, for the purpose of determining any liability under the Securities Act,
each such post-effective amendment shall be deemed to be a new registration statement relating to the securities offered therein,
and the offering of such securities at that time shall be deemed to be the initial bona fide offering thereof.
To remove from registration by means of a post-effective amendment any of the
securities being registered which remain unsold at the termination of the offering.
The undersigned Registrant hereby undertakes that, for purposes of determining
any liability under the Securities Act, each filing of the Registrant's annual report pursuant to Section 13(a) or 15(d) of the
Exchange Act (and, where applicable, each filing of an employee benefit plan's annual report pursuant to Section 15(d) of the
Exchange Act) that is incorporated by reference in this Registration Statement shall be deemed to be a new registration statement
relating to the securities offered therein, and the offering of such securities at that time shall be deemed to be the initial
bona fide offering thereof.
Insofar as indemnification for liabilities arising under the Securities Act may
be permitted to directors, officers and controlling persons of the Registrant pursuant to the foregoing provisions, or otherwise, the
Registrant has been advised that in the opinion of the SEC such indemnification is against public policy as expressed in the Securities
Act and is, therefore, unenforceable.  In the event that a claim for indemnification against such liabilities (other than the payment
by the Registrant of expenses incurred or paid by a director, officer or controlling person of the Registrant in the successful
defense of any action, suit or proceeding) is asserted by such director, officer or controlling person in connection with the securities
being registered, the Registrant will, unless in the opinion of its counsel the matter has been settled by controlling precedent,
submit to a court of appropriate jurisdiction the question whether such indemnification by it is against public policy as expressed
in the Securities Act and will be governed by the final adjudication of such issue.
SIGNATURES
Pursuant to the requirements of the Securities Act,
the Company certifies that it has reasonable grounds to believe that it meets all of the requirements for filing on Form S-8 and
has duly caused this Registration Statement to be signed on its behalf by the undersigned, thereunto duly authorized, in the
City of San Diego, State of California, on this sixth day of June 2003.
NEUROCRINE BIOSCIENCES, INC.
By:
/s/ Gary A. Lyons
Gary A. Lyons
President and Chief Executive Officer
POWER OF ATTORNEY
KNOW ALL PERSONS BY THESE PRESENTS,
that each such person whose signature appears below constitutes and appoints, jointly and severally, Gary A. Lyons and
Paul W. Hawran his attorneys-in-fact, each with the power of substitution, for him in any and all capacities, to sign
any amendments to this Registration Statement on Form S-8 (including post-effective amendments), and to file the same,
with all exhibits thereto, and other documents in connection therewith, with the SEC, hereby ratifying and confirming
all that each of said attorneys-in-fact, or his substitute or substitutes, may do or cause to be done by virtue hereof.
Pursuant to the requirements of the Securities
Act, this Registration Statement has been signed by the following persons in the capacities and on the dates indicated.
Signature
Title
Date
/s/ Gary A. Lyons
President, Chief Executive Officer and Director
(Principal Executive Officer)
June 6, 2003
Gary A. Lyons
/s/ Paul W. Hawran
Executive Vice President and Chief Financial Officer (Principal Financial and Accounting Officer)
June 6, 2003
Paul W. Hawran
/s/ Joseph A. Mollica
Chairman of the Board of Directors
June 6, 2003
Joseph A. Mollica
/s/ W. Thomas Mitchell
Director
June 6, 2003
W. Thomas Mitchell
/s/ Richard F. Pops
Director
June 6, 2003
Richard F. Pops
/s/ Stephen A. Sherwin
Director
June 6, 2003
Stephen A. Sherwin
/s/ Lawrence  Steinman
Director
June 6, 2003
Lawrence  Steinman
/s/ Wylie W. Vale
Director
June 6, 2003
Wylie W. Vale
INDEX TO EXHIBITS
Exhibit
Number
Document
4.1 (1)
Form of Common Stock Certificate
4.2*
Neurocrine Biosciences, Inc. 2003 Incentive Stock Plan
5.1*
Opinion of Latham & Watkins LLP
23.1*
Consent of Ernst & Young LLP, Independent Auditors
23.2*
Consent of Latham & Watkins LLP (contained in Exhibit 5.1)
24.1*
Power of Attorney (included in the signature page of this Registration Statement)
*       Filed herewith.
(1)     Incorporated by reference to the Company's Registration Statement filed on April 3, 1996 on Form S-1, as
         amended (File No. 333-03172).