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<p align="center" style="margin:12.0pt 0in .0001pt;text-align:center;text-indent:.5in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">As filed with the
Securities and Exchange Commission on April 19, 2002</font></p>

<p align="right" style="margin:0in 0in .0001pt;text-align:right;text-indent:0in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;letter-spacing:-.1pt;">Registration
No. 333-</font></p>

<p align="right" style="margin:0in 0in .0001pt;text-align:right;text-indent:0in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>

<table border="1" cellspacing="0" cellpadding="0" width="100%" style="border:none;border-collapse:collapse;font-family:'Times New Roman';width:100.0%;">
 <tr>
  <td width="5" style="border:none;font-size:12.0pt;padding:0in 0in 0in 0in;"><p style="margin:12.0pt 0in .0001pt;text-align:justify;text-indent:.5in;">&nbsp;</p></td>
  <td width="716" colspan="17" valign="top" style="border:none;padding:0in 0in 0in 0in;width:537.0pt;">
  <div style="border:none;border-top:double windowtext 9.0pt;padding:0in 0in 0in 0in;">
  <p style="border:none;font-size:12.0pt;margin:0in 0in .0001pt;padding:0in;text-align:justify;text-indent:0in;">&nbsp;</p>
  </div>
  </td>
 </tr>
 <tr height="32" style="height:24.0pt;">
  <td width="5" style="border:none;font-size:1.0pt;padding:0in 0in 0in 0in;"><p style="margin:12.0pt 0in .0001pt;text-align:justify;text-indent:.5in;">&nbsp;</p></td>
  <td width="51" rowspan="2" valign="top" style="border:none;height:24.0pt;padding:0in 0in 0in 0in;width:38.6pt;">
  <p align="center" style="font-size:1.0pt;margin:0in 0in .0001pt;text-align:center;text-indent:0in;">&nbsp;</p>
  </td>
  <td width="576" colspan="14" height="32" valign="top" style="border:none;height:24.0pt;padding:0in 0in 0in 0in;width:6.0in;">
  <p align="center" style="margin:0in 0in .0001pt;text-align:center;text-indent:0in;"><b><font size="5" face="Times New Roman" style="font-size:18.0pt;font-weight:bold;letter-spacing:-.2pt;">SECURITIES
  AND EXCHANGE COMMISSION</font></b></p>
  <p align="center" style="margin:0in 0in .0001pt;text-align:center;text-indent:0in;"><b><font size="2" face="Times New Roman" style="font-size:10.0pt;font-weight:bold;letter-spacing:-.1pt;">Washington, D.C. 20549</font></b></p>
  <p align="center" style="font-size:1.0pt;margin:0in 0in .0001pt;text-align:center;text-indent:0in;">&nbsp;</p>
  </td>
  <td width="89" colspan="2" rowspan="2" valign="top" style="border:none;height:24.0pt;padding:0in 0in 0in 0in;width:66.4pt;">
  <p align="center" style="font-size:1.0pt;margin:12.0pt 0in .0001pt;text-align:center;text-indent:.5in;">&nbsp;</p>
  </td>
 </tr>
 <tr height="32" style="height:24.0pt;">
  <td width="5" style="border:none;font-size:12.0pt;padding:0in 0in 0in 0in;"><p style="margin:12.0pt 0in .0001pt;text-align:justify;text-indent:.5in;">&nbsp;</p></td>
  <td width="576" colspan="14" height="32" valign="top" style="border:none;height:24.0pt;padding:0in 0in 0in 0in;width:6.0in;">
  <div align="center" style="margin:3.0pt 0in;text-align:center;text-indent:0in;"><b><font size="2" face="Times New Roman" style="font-size:10.0pt;font-weight:bold;letter-spacing:-.2pt;">
  <hr size="1" width="28%" noshade color="black" align="center">
  </font></b></div>
  <p align="center" style="margin:3.0pt 0in;text-align:center;text-indent:0in;"></p>
  </td>
 </tr>
 <tr height="18" style="height:13.5pt;">
  <td width="5" style="border:none;font-size:1.0pt;padding:0in 0in 0in 0in;"><p style="margin:12.0pt 0in .0001pt;text-align:justify;text-indent:.5in;">&nbsp;</p></td>
  <td width="51" height="18" valign="top" style="border:none;height:13.5pt;padding:0in 0in 0in 0in;width:38.6pt;">
  <p align="center" style="font-size:1.0pt;margin:0in 0in .0001pt;text-align:center;text-indent:0in;">&nbsp;</p>
  </td>
  <td width="576" colspan="14" height="18" valign="top" style="border:none;height:13.5pt;padding:0in 0in 0in 0in;width:6.0in;">
  <p align="center" style="margin:0in 0in .0001pt;text-align:center;text-indent:0in;"><b><font size="5" face="Times New Roman" style="font-size:18.0pt;font-weight:bold;letter-spacing:-.2pt;">FORM S-8</font></b></p>
  <p align="center" style="margin:0in 0in .0001pt;text-align:center;text-indent:0in;"><b><font size="5" face="Times New Roman" style="font-size:16.0pt;font-weight:bold;letter-spacing:-.15pt;">REGISTRATION
  STATEMENT</font></b></p>
  <p align="center" style="margin:0in 0in .0001pt;text-align:center;text-indent:0in;"><b><font size="2" face="Times New Roman" style="font-size:10.0pt;font-weight:bold;letter-spacing:-.1pt;">Under</font></b></p>
  <p align="center" style="margin:0in 0in .0001pt;text-align:center;text-indent:0in;"><b><font size="2" face="Times New Roman" style="font-size:10.0pt;font-weight:bold;letter-spacing:-.1pt;">The Securities Act of 1933</font></b></p>
  </td>
  <td width="89" colspan="2" height="18" valign="top" style="border:none;height:13.5pt;padding:0in 0in 0in 0in;width:66.4pt;">
  <p align="center" style="font-size:1.0pt;margin:0in 0in .0001pt;text-align:center;text-indent:0in;">&nbsp;</p>
  </td>
 </tr>
 <tr height="18" style="height:13.5pt;">
  <td width="5" style="border:none;font-size:1.0pt;padding:0in 0in 0in 0in;"><p style="margin:12.0pt 0in .0001pt;text-align:justify;text-indent:.5in;">&nbsp;</p></td>
  <td width="51" height="18" valign="top" style="border:none;height:13.5pt;padding:0in 0in 0in 0in;width:38.6pt;">
  <p align="center" style="font-size:1.0pt;margin:0in 0in .0001pt;text-align:center;text-indent:0in;">&nbsp;</p>
  </td>
  <td width="576" colspan="14" height="18" valign="top" style="border:none;height:13.5pt;padding:0in 0in 0in 0in;width:6.0in;">
  <p align="center" style="margin:0in 0in .0001pt;text-align:center;text-indent:0in;"><b><font size="5" face="Times New Roman" style="font-size:18.0pt;font-weight:bold;letter-spacing:-.2pt;">SUPERGEN,
  INC.</font></b></p>
  <p align="center" style="margin:0in 0in .0001pt 2.4pt;text-align:center;text-indent:-2.4pt;"><font size="2" face="Times New Roman" style="font-size:10.0pt;letter-spacing:-.1pt;">(Exact name of Registrant as specified in its
  charter)</font></p>
  </td>
  <td width="89" colspan="2" height="18" valign="top" style="border:none;height:13.5pt;padding:0in 0in 0in 0in;width:66.4pt;">
  <p align="center" style="font-size:1.0pt;margin:0in 0in .0001pt;text-align:center;text-indent:0in;">&nbsp;</p>
  </td>
 </tr>
 <tr>
  <td width="5" style="border:none;font-size:1.0pt;padding:0in 0in 0in 0in;"><p style="margin:12.0pt 0in .0001pt;text-align:justify;text-indent:.5in;">&nbsp;</p></td>
  <td width="234" colspan="3" valign="top" style="border:none;padding:0in 0in 0in 0in;width:175.75pt;">
  <p align="center" style="margin:0in 0in .0001pt;text-align:center;text-indent:0in;"><b><font size="2" face="Times New Roman" style="font-size:10.0pt;font-weight:bold;letter-spacing:-.1pt;">Delaware</font></b></p>
  <p align="center" style="margin:0in 0in .0001pt;text-align:center;text-indent:0in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;letter-spacing:-.1pt;">(State
  or other jurisdiction of</font></p>
  <p align="center" style="margin:0in 0in .0001pt;text-align:center;text-indent:0in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;letter-spacing:-.1pt;">incorporation
  or organization)</font></p>
  </td>
  <td width="243" colspan="9" valign="top" style="border:none;padding:0in 0in 0in 0in;width:182.5pt;">
  <p align="center" style="font-size:1.0pt;margin:0in 0in .0001pt;text-align:center;text-indent:0in;">&nbsp;</p>
  </td>
  <td width="238" colspan="5" valign="top" style="border:none;padding:0in 0in 0in 0in;width:178.75pt;">
  <p align="center" style="margin:0in 0in .0001pt;text-align:center;text-indent:0in;"><b><font size="2" face="Times New Roman" style="font-size:10.0pt;font-weight:bold;letter-spacing:-.1pt;">91-1841574</font></b></p>
  <p align="center" style="margin:0in 0in .0001pt;text-align:center;text-indent:0in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;letter-spacing:-.1pt;">(I.R.S.
  Employer Identification Number)</font></p>
  </td>
 </tr>
 <tr>
  <td width="5" style="border:none;font-size:1.0pt;padding:0in 0in 0in 0in;"><p style="margin:12.0pt 0in .0001pt;text-align:justify;text-indent:.5in;">&nbsp;</p></td>
  <td width="234" colspan="3" valign="top" style="border:none;padding:0in 0in 0in 0in;width:175.75pt;">
  <p align="center" style="font-size:1.0pt;margin:0in 0in .0001pt;text-align:center;text-indent:0in;">&nbsp;</p>
  </td>
  <td width="243" colspan="9" valign="top" style="border:none;padding:0in 0in 0in 0in;width:182.5pt;">
  <p style="font-weight:bold;margin:0in 0in .0001pt;text-align:center;"><b><font size="2" face="Times New Roman" style="font-size:1.0pt;">&nbsp;</font></b></p>
  <p style="font-weight:bold;margin:0in 0in .0001pt;text-align:center;"><b><font size="2" face="Times New Roman" style="font-size:10.0pt;letter-spacing:-.1pt;">4140
  Dublin Boulevard, Suite 200</font></b></p>
  <p align="center" style="margin:0in 0in .0001pt;text-align:center;text-indent:0in;"><b><font size="2" face="Times New Roman" style="font-size:10.0pt;font-weight:bold;letter-spacing:-.1pt;">Dublin, California&#160; 94568</font></b></p>
  </td>
  <td width="238" colspan="5" valign="top" style="border:none;padding:0in 0in 0in 0in;width:178.75pt;">
  <p align="center" style="font-size:1.0pt;margin:0in 0in .0001pt;text-align:center;text-indent:0in;">&nbsp;</p>
  </td>
 </tr>
 <tr>
  <td width="5" style="border:none;font-size:1.0pt;padding:0in 0in 0in 0in;"><p style="margin:12.0pt 0in .0001pt;text-align:justify;text-indent:.5in;">&nbsp;</p></td>
  <td width="234" colspan="3" valign="top" style="border:none;padding:0in 0in 0in 0in;width:175.75pt;">
  <p align="center" style="font-size:1.0pt;margin:0in 0in .0001pt;text-align:center;text-indent:0in;">&nbsp;</p>
  </td>
  <td width="243" colspan="9" valign="top" style="border:none;padding:0in 0in 0in 0in;width:182.5pt;">
  <p align="center" style="margin:0in 0in .0001pt;text-align:center;text-indent:0in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;letter-spacing:-.1pt;">(Address
  of principal executive offices)</font></p>
  </td>
  <td width="238" colspan="5" valign="top" style="border:none;padding:0in 0in 0in 0in;width:178.75pt;">
  <p align="center" style="font-size:1.0pt;margin:0in 0in .0001pt;text-align:center;text-indent:0in;">&nbsp;</p>
  </td>
 </tr>
 <tr>
  <td width="5" style="border:none;font-size:12.0pt;padding:0in 0in 0in 0in;"><p style="margin:12.0pt 0in .0001pt;text-align:justify;text-indent:.5in;">&nbsp;</p></td>
  <td width="235" colspan="4" valign="top" style="border:none;padding:0in 0in 0in 0in;width:176.5pt;">
  <p align="center" style="font-size:12.0pt;margin:0in 0in .0001pt;text-align:center;text-indent:0in;">&nbsp;</p>
  </td>
  <td width="240" colspan="4" valign="top" style="border:none;padding:0in 0in 0in 0in;width:179.9pt;">
  <div align="center" style="margin:0in 0in .0001pt;text-align:center;text-indent:0in;"><b><font size="2" face="Times New Roman" style="font-size:10.0pt;font-weight:bold;letter-spacing:-.1pt;">
  <hr size="1" width="62%" noshade color="black" align="center">
  </font></b></div>
  <p align="center" style="margin:0in 0in .0001pt;text-align:center;text-indent:0in;"></p>
  </td>
  <td width="241" colspan="9" valign="top" style="border:none;padding:0in 0in 0in 0in;width:180.6pt;">
  <p align="center" style="font-size:12.0pt;margin:0in 0in .0001pt;text-align:center;text-indent:0in;">&nbsp;</p>
  </td>
 </tr>
 <tr>
  <td width="5" style="border:none;font-size:1.0pt;padding:0in 0in 0in 0in;"><p style="margin:12.0pt 0in .0001pt;text-align:justify;text-indent:.5in;">&nbsp;</p></td>
  <td width="227" colspan="2" valign="top" style="border:none;padding:0in 0in 0in 0in;width:170.6pt;">
  <p align="center" style="font-size:1.0pt;margin:0in 0in .0001pt;text-align:center;text-indent:0in;">&nbsp;</p>
  </td>
  <td width="250" colspan="9" valign="top" style="border:none;padding:0in 0in 0in 0in;width:187.4pt;">
  <p align="center" style="margin:0in 0in .0001pt;text-align:center;text-indent:0in;"><b><font size="2" face="Times New Roman" style="font-size:10.0pt;font-weight:bold;letter-spacing:-.1pt;">1996 Directors&#146; Stock Option Plan</font></b></p>
  <p align="center" style="margin:0in 0in .0001pt;text-align:center;text-indent:0in;"><b><font size="2" face="Times New Roman" style="font-size:10.0pt;font-weight:bold;letter-spacing:-.1pt;">1998 Employee Stock Purchase Plan</font></b></p>
  <p align="center" style="margin:0in 0in .0001pt;text-align:center;text-indent:0in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;letter-spacing:-.1pt;">(Full
  titles of the plans)</font></p>
  </td>
  <td width="239" colspan="6" valign="top" style="border:none;padding:0in 0in 0in 0in;width:179.0pt;">
  <p align="center" style="font-size:1.0pt;margin:0in 0in .0001pt;text-align:center;text-indent:0in;">&nbsp;</p>
  </td>
 </tr>
 <tr>
  <td width="5" style="border:none;font-size:12.0pt;padding:0in 0in 0in 0in;"><p style="margin:12.0pt 0in .0001pt;text-align:justify;text-indent:.5in;">&nbsp;</p></td>
  <td width="235" colspan="4" valign="top" style="border:none;padding:0in 0in 0in 0in;width:176.5pt;">
  <p align="center" style="font-size:12.0pt;margin:0in 0in .0001pt;text-align:center;text-indent:0in;">&nbsp;</p>
  </td>
  <td width="242" colspan="6" valign="top" style="border:none;padding:0in 0in 0in 0in;width:181.3pt;">
  <div align="center" style="margin:0in 0in .0001pt;text-align:center;text-indent:0in;"><b><font size="2" face="Times New Roman" style="font-size:10.0pt;font-weight:bold;letter-spacing:-.1pt;">
  <hr size="1" width="63%" noshade color="black" align="center">
  </font></b></div>
  <p align="center" style="margin:0in 0in .0001pt;text-align:center;text-indent:0in;"></p>
  </td>
  <td width="239" colspan="7" valign="top" style="border:none;padding:0in 0in 0in 0in;width:179.2pt;">
  <p align="center" style="font-size:12.0pt;margin:0in 0in .0001pt;text-align:center;text-indent:0in;">&nbsp;</p>
  </td>
 </tr>
 <tr>
  <td width="5" style="border:none;font-size:1.0pt;padding:0in 0in 0in 0in;"><p style="margin:12.0pt 0in .0001pt;text-align:justify;text-indent:.5in;">&nbsp;</p></td>
  <td width="234" colspan="3" valign="top" style="border:none;padding:0in 0in 0in 0in;width:175.75pt;">
  <p align="center" style="font-size:1.0pt;margin:0in 0in .0001pt;text-align:center;text-indent:0in;">&nbsp;</p>
  </td>
  <td width="241" colspan="6" valign="top" style="border:none;padding:0in 0in 0in 0in;width:180.85pt;">
  <p align="center" style="margin:0in 0in .0001pt;text-align:center;text-indent:0in;"><b><font size="2" face="Times New Roman" style="font-size:10.0pt;font-weight:bold;letter-spacing:-.1pt;">Joseph Rubinfeld, Ph.D.</font></b></p>
  <p align="center" style="margin:0in 0in .0001pt;text-align:center;text-indent:0in;"><b><font size="2" face="Times New Roman" style="font-size:10.0pt;font-weight:bold;letter-spacing:-.1pt;">Chief Executive Officer</font></b></p>
  <p align="center" style="margin:0in 0in .0001pt;text-align:center;text-indent:0in;"><b><font size="2" face="Times New Roman" style="font-size:10.0pt;font-weight:bold;letter-spacing:-.1pt;">SUPERGEN, INC.</font></b></p>
  <p align="center" style="margin:0in 0in .0001pt;text-align:center;text-indent:0in;"><b><font size="2" face="Times New Roman" style="font-size:10.0pt;font-weight:bold;letter-spacing:-.1pt;">4140 Dublin Boulevard, Suite 200</font></b></p>
  <p align="center" style="margin:0in 0in .0001pt;text-align:center;text-indent:0in;"><b><font size="2" face="Times New Roman" style="font-size:10.0pt;font-weight:bold;letter-spacing:-.1pt;">Dublin, California&#160; 94568</font></b></p>
  <p align="center" style="margin:0in 0in .0001pt;text-align:center;text-indent:0in;"><b><font size="2" face="Times New Roman" style="font-size:10.0pt;font-weight:bold;letter-spacing:-.1pt;">(925) 560-0100</font></b></p>
  </td>
  <td width="241" colspan="8" valign="top" style="border:none;padding:0in 0in 0in 0in;width:180.4pt;">
  <p align="center" style="font-size:1.0pt;margin:0in 0in .0001pt;text-align:center;text-indent:0in;">&nbsp;</p>
  </td>
 </tr>
 <tr>
  <td width="5" style="border:none;font-size:1.0pt;padding:0in 0in 0in 0in;"><p style="margin:12.0pt 0in .0001pt;text-align:justify;text-indent:.5in;">&nbsp;</p></td>
  <td width="234" colspan="3" valign="top" style="border:none;padding:0in 0in 0in 0in;width:175.75pt;">
  <p align="center" style="font-size:1.0pt;margin:0in 0in .0001pt;text-align:center;text-indent:0in;">&nbsp;</p>
  </td>
  <td width="241" colspan="6" valign="top" style="border:none;padding:0in 0in 0in 0in;width:180.85pt;">
  <p align="center" style="margin:0in 0in .0001pt;text-align:center;text-indent:0in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;letter-spacing:-.1pt;">(Name,
  address and telephone number of agent for service)</font></p>
  </td>
  <td width="241" colspan="8" valign="top" style="border:none;padding:0in 0in 0in 0in;width:180.4pt;">
  <p align="center" style="font-size:1.0pt;margin:0in 0in .0001pt;text-align:center;text-indent:0in;">&nbsp;</p>
  </td>
 </tr>
 <tr>
  <td width="5" style="border:none;font-size:12.0pt;padding:0in 0in 0in 0in;"><p style="margin:12.0pt 0in .0001pt;text-align:justify;text-indent:.5in;">&nbsp;</p></td>
  <td width="235" colspan="4" valign="top" style="border:none;padding:0in 0in 0in 0in;width:176.5pt;">
  <p align="center" style="font-size:12.0pt;margin:0in 28.2pt .0001pt 25.7pt;text-align:center;text-indent:0in;">&nbsp;</p>
  </td>
  <td width="242" colspan="6" valign="top" style="border:none;padding:0in 0in 0in 0in;width:181.3pt;">
  <div align="center" style="margin:0in 28.2pt .0001pt 25.7pt;text-align:center;text-indent:0in;"><b><font size="2" face="Times New Roman" style="font-size:10.0pt;font-weight:bold;letter-spacing:-.1pt;">
  <hr size="1" width="92%" noshade color="black" align="center">
  </font></b></div>
  <p align="center" style="margin:0in 28.2pt .0001pt 25.7pt;text-align:center;text-indent:0in;"></p>
  </td>
  <td width="239" colspan="7" valign="top" style="border:none;padding:0in 0in 0in 0in;width:179.2pt;">
  <p align="center" style="font-size:12.0pt;margin:0in 28.2pt .0001pt 25.7pt;text-align:center;text-indent:0in;">&nbsp;</p>
  </td>
 </tr>
 <tr>
  <td width="5" style="border:none;font-size:1.0pt;padding:0in 0in 0in 0in;"><p style="margin:12.0pt 0in .0001pt;text-align:justify;text-indent:.5in;">&nbsp;</p></td>
  <td width="235" colspan="4" valign="top" style="border:none;padding:0in 0in 0in 0in;width:176.5pt;">
  <p align="center" style="font-size:1.0pt;margin:0in 0in .0001pt;text-align:center;text-indent:0in;">&nbsp;</p>
  </td>
  <td width="240" colspan="4" valign="top" style="border:none;padding:0in 0in 0in 0in;width:179.9pt;">
  <p align="center" style="margin:0in 0in .0001pt;text-align:center;text-indent:0in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;letter-spacing:-.1pt;">Copy
  to:</font></p>
  </td>
  <td width="241" colspan="9" valign="top" style="border:none;padding:0in 0in 0in 0in;width:180.6pt;">
  <p align="center" style="font-size:1.0pt;margin:0in 0in .0001pt;text-align:center;text-indent:0in;">&nbsp;</p>
  </td>
 </tr>
 <tr>
  <td width="5" style="border:none;font-size:1.0pt;padding:0in 0in 0in 0in;"><p style="margin:12.0pt 0in .0001pt;text-align:justify;text-indent:.5in;">&nbsp;</p></td>
  <td width="235" colspan="4" valign="top" style="border:none;padding:0in 0in 0in 0in;width:176.5pt;">
  <p align="center" style="font-size:1.0pt;margin:0in 0in .0001pt;text-align:center;text-indent:0in;">&nbsp;</p>
  </td>
  <td width="240" colspan="4" valign="top" style="border:none;padding:0in 0in 0in 0in;width:179.9pt;">
  <p align="center" style="margin:0in 0in .0001pt;text-align:center;text-indent:0in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;letter-spacing:-.1pt;">John
  V. Roos, Esq.</font></p>
  <p align="center" style="margin:0in 0in .0001pt;text-align:center;text-indent:0in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;letter-spacing:-.1pt;">Wilson
  Sonsini Goodrich &amp; Rosati, P.C.</font></p>
  <p align="center" style="margin:0in 0in .0001pt;text-align:center;text-indent:0in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;letter-spacing:-.1pt;">650
  Page Mill Road</font></p>
  <p align="center" style="margin:0in 0in .0001pt;text-align:center;text-indent:0in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;letter-spacing:-.1pt;">Palo
  Alto, California 94304</font></p>
  </td>
  <td width="241" colspan="9" valign="top" style="border:none;padding:0in 0in 0in 0in;width:180.6pt;">
  <p align="center" style="font-size:1.0pt;margin:0in 0in .0001pt;text-align:center;text-indent:0in;">&nbsp;</p>
  </td>
 </tr>
 <tr>
  <td width="5" style="border:none;font-size:12.0pt;padding:0in 0in 0in 0in;"><p style="margin:12.0pt 0in .0001pt;text-align:justify;text-indent:.5in;">&nbsp;</p></td>
  <td width="239" colspan="5" valign="top" style="border:none;padding:0in 0in 0in 0in;width:179.0pt;">
  <p align="center" style="margin:0in 0in .0001pt;text-align:center;text-indent:0in;"><b><font size="2" face="Times New Roman" style="font-size:10.0pt;font-weight:bold;letter-spacing:-.1pt;">&nbsp;</font></b></p>
  <p align="center" style="font-size:12.0pt;margin:0in 0in .0001pt;text-align:center;text-indent:0in;">&nbsp;</p>
  </td>
  <td width="239" colspan="6" valign="top" style="border:none;padding:0in 0in 0in 0in;width:179.0pt;">
  <div align="center" style="margin:0in 0in .0001pt;text-align:center;text-indent:0in;"><b><font size="2" face="Times New Roman" style="font-size:10.0pt;font-weight:bold;letter-spacing:-.1pt;">
  <hr size="1" width="74%" noshade color="black" align="center">
  </font></b></div>
  <p align="center" style="font-size:12.0pt;margin:0in 0in .0001pt;text-align:center;text-indent:0in;">&nbsp;</p>
  </td>
  <td width="239" colspan="6" valign="top" style="border:none;padding:0in 0in 0in 0in;width:179.0pt;">
  <p align="center" style="margin:0in 0in .0001pt;text-align:center;text-indent:0in;"><b><font size="2" face="Times New Roman" style="font-size:10.0pt;font-weight:bold;letter-spacing:-.1pt;">&nbsp;</font></b></p>
  <p align="center" style="font-size:12.0pt;margin:0in 0in .0001pt;text-align:center;text-indent:0in;">&nbsp;</p>
  </td>
 </tr>
 <tr>
  <td width="714" colspan="17" valign="bottom" style="border:none;border-bottom:solid windowtext .5pt;padding:0in 4.3pt 0in 4.3pt;width:535.5pt;">
  <p align="center" style="margin:0in 0in .0001pt;text-align:center;text-indent:0in;"><b><font size="2" face="Times New Roman" style="font-size:1.0pt;font-weight:bold;letter-spacing:-.1pt;">&nbsp;</font></b></p>
  <p align="center" style="margin:0in 0in .0001pt;text-align:center;text-indent:0in;"><b><font size="2" face="Times New Roman" style="font-size:10.0pt;font-weight:bold;letter-spacing:-.1pt;">CALCULATION OF REGISTRATION FEE</font></b></p>
  </td>
  <td width="7" style="border:none;font-size:1.0pt;padding:0in 0in 0in 0in;"><p style="margin:12.0pt 0in .0001pt;text-align:justify;text-indent:.5in;">&nbsp;</p></td>
 </tr>
 <tr>
  <td width="280" colspan="7" valign="bottom" style="border:none;border-bottom:solid windowtext .5pt;padding:0in 4.3pt 0in 4.3pt;width:210.35pt;">
  <p align="center" style="margin:0in 0in .0001pt;text-align:center;text-indent:0in;"><font size="2" style="font-size:10.0pt;letter-spacing:-.1pt;">Title of Securities to be
  Registered</font></p>
  </td>
  <td width="107" valign="bottom" style="border:none;border-bottom:solid windowtext .5pt;padding:0in 4.3pt 0in 4.3pt;width:80.0pt;">
  <p align="center" style="margin:0in 0in .0001pt;text-align:center;text-indent:0in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;letter-spacing:-.1pt;">Amount
  to be<br>
  Registered (1)</font></p>
  </td>
  <td width="119" colspan="6" valign="bottom" style="border:none;border-bottom:solid windowtext .5pt;padding:0in 4.3pt 0in 4.3pt;width:89.5pt;">
  <p align="center" style="margin:0in 0in .0001pt;text-align:center;text-indent:0in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;letter-spacing:-.1pt;">Proposed
  Maximum<br>
  Offering Price<br>
  Per Share (2)</font></p>
  </td>
  <td width="113" valign="bottom" style="border:none;border-bottom:solid windowtext .5pt;padding:0in 4.3pt 0in 4.3pt;width:84.4pt;">
  <p align="center" style="margin:0in 0in .0001pt;text-align:center;text-indent:0in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;letter-spacing:-.1pt;">Proposed
  Maximum<br>
  Aggregate<br>
  Offering Price (2)</font></p>
  </td>
  <td width="95" colspan="2" valign="bottom" style="border:none;border-bottom:solid windowtext .5pt;padding:0in 4.3pt 0in 4.3pt;width:71.25pt;">
  <p align="center" style="margin:0in 0in .0001pt;text-align:center;text-indent:0in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;letter-spacing:-.1pt;">Amount
  of<br>
  Registration Fee</font></p>
  </td>
  <td width="7" style="border:none;font-size:1.0pt;padding:0in 0in 0in 0in;"><p style="margin:12.0pt 0in .0001pt;text-align:justify;text-indent:.5in;">&nbsp;</p></td>
 </tr>
 <tr>
  <td width="280" colspan="7" style="border:none;border-bottom:solid windowtext .5pt;padding:0in 4.3pt 0in 4.3pt;width:210.35pt;">
  <p align="left" style="margin:0in 0in .0001pt;text-align:left;text-indent:0in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;letter-spacing:-.1pt;">Common
  Stock, $.001 par value</font></p>
  </td>
  <td width="107" style="border:none;border-bottom:solid windowtext .5pt;padding:0in 4.3pt 0in 4.3pt;width:80.0pt;">
  <p align="center" style="margin:0in 0in .0001pt;text-align:center;text-indent:0in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;letter-spacing:-.1pt;">500,000</font></p>
  </td>
  <td width="119" colspan="6" style="border:none;border-bottom:solid windowtext .5pt;padding:0in 4.3pt 0in 4.3pt;width:89.5pt;">
  <p align="center" style="margin:0in 0in .0001pt;text-align:center;text-indent:0in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;letter-spacing:-.1pt;">$5.65</font></p>
  </td>
  <td width="113" style="border:none;border-bottom:solid windowtext .5pt;padding:0in 4.3pt 0in 4.3pt;width:84.4pt;">
  <p align="center" style="margin:0in 0in .0001pt;text-align:center;text-indent:0in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;letter-spacing:-.1pt;">$2,825,000</font></p>
  </td>
  <td width="95" colspan="2" style="border:none;border-bottom:solid windowtext .5pt;padding:0in 4.3pt 0in 4.3pt;width:71.25pt;">
  <p align="center" style="margin:0in 0in .0001pt;text-align:center;text-indent:0in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;letter-spacing:-.1pt;">$259.90</font></p>
  </td>
  <td width="7" style="border:none;font-size:1.0pt;padding:0in 0in 0in 0in;"><p style="margin:12.0pt 0in .0001pt;text-align:justify;text-indent:.5in;">&nbsp;</p></td>
 </tr>
 <tr height="0">
  <td width="5" style="border:none;"></td>
  <td width="51" style="border:none;"></td>
  <td width="176" style="border:none;"></td>
  <td width="7" style="border:none;"></td>
  <td width="1" style="border:none;"></td>
  <td width="3" style="border:none;"></td>
  <td width="37" style="border:none;"></td>
  <td width="107" style="border:none;"></td>
  <td width="93" style="border:none;"></td>
  <td width="0" style="border:none;"></td>
  <td width="2" style="border:none;"></td>
  <td width="0" style="border:none;"></td>
  <td width="0" style="border:none;"></td>
  <td width="24" style="border:none;"></td>
  <td width="113" style="border:none;"></td>
  <td width="14" style="border:none;"></td>
  <td width="81" style="border:none;"></td>
  <td width="7" style="border:none;"></td>
 </tr>
</table>

<p align="left" style="margin:3.0pt 0in .0001pt .25in;text-align:left;text-indent:-.25in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;letter-spacing:-.1pt;">__________</font></p>

<p align="left" style="font-family:'Times New Roman';margin:3.0pt 0in .0001pt .25in;text-align:left;text-indent:-.25in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;letter-spacing:-.1pt;">(1)</font><font size="1" style="font-size:3.0pt;letter-spacing:-.1pt;">&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; </font><font size="2" style="font-size:10.0pt;letter-spacing:-.1pt;">Pursuant to Rule 429
of the Securities Act of 1933, as amended (the &#147;Securities Act&#148;), the
prospectus delivered to participants under the Registrant&#146;s 1996 Directors&#146;
Stock Option Plan, as amended (the &#147;Directors&#146; Plan&#148;), also relates to 250,000
shares previously registered under Form S-8 Registration No. 333-07295.&#160; Pursuant to Rule 429 of the Securities Act,
the prospectus delivered to participants under the Registrant&#146;s 1998 Employee
Stock Purchase Plan, as amended (the &#147;Purchase Plan&#148;), also relates to 100,000
shares previously registered under Form S-8 Registration No. 333-58303.&#160; Includes 300,000 shares to be registered
under the Directors&#146; Plan and 200,000 shares to be registered under the
Purchase Plan.</font></p>

<p align="left" style="font-family:'Times New Roman';margin:3.0pt 0in .0001pt .25in;text-align:left;text-indent:-.25in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;letter-spacing:-.1pt;">(2)</font><font size="1" style="font-size:3.0pt;letter-spacing:-.1pt;">&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; </font><font size="2" style="font-size:10.0pt;letter-spacing:-.1pt;">The Proposed Maximum
Offering Price Per Share was estimated pursuant to Rule 457(c) under the
Securities Act whereby the per share price was determined by reference to the
average between the high and low prices reported in the Nasdaq National Market
on April 12, 2002, which average was $5.65.</font></p>

<p align="left" style="margin:3.0pt 0in .0001pt .25in;text-align:left;text-indent:-.25in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>

<div style="border:none;border-bottom:double windowtext 9.0pt;padding:0in 0in 0in 0in;">

<p align="left" style="border:none;margin:3.0pt 0in .0001pt .25in;padding:0in;text-align:left;text-indent:-.25in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>

</div>


<div align="left" style="margin:12.0pt 0in .0001pt;text-align:left;text-indent:0in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">

<hr size="2" width="100%" noshade color="gray" align="left">

</font></div>

<font size="2" face="Times New Roman" style="font-size:10.0pt;">
<!-- ZEQ.=1,SEQ=1,EFW="2076728",CP="SUPERGEN, INC.",DN="1",CHK=486110,FOLIO='',FILE="DISK012:[02PAL7.02PAL1547.EDGAR]S-8_1547.CHC",USER="DNICHOL",CD='Apr 19 13:31 2002' -->
<br clear="all" style="page-break-before:always;">
</font>

<p align="center" style="font-family:'Times New Roman';font-size:12.0pt;margin:12.0pt 0in .0001pt;text-align:center;text-indent:0in;">&nbsp;</p>

<p align="center" style="margin:12.0pt 0in .0001pt;text-align:center;text-indent:0in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">PART II</font></p>

<p align="center" style="margin:12.0pt 0in .0001pt;text-align:center;text-indent:0in;"><u><font size="2" face="Times New Roman" style="font-size:10.0pt;">INFORMATION
REQUIRED IN THE REGISTRATION STATEMENT</font></u></p>

<p align="left" style="font-family:'Times New Roman';margin:24.0pt 0in .0001pt;text-align:left;text-indent:0in;"><u><font size="2" face="Times New Roman" style="font-size:10.0pt;">Item 3</font></u><font size="2" style="font-size:10.0pt;">. <u>Incorporation of Documents by Reference</u></font></p>

<p align="left" style="margin:12.0pt 0in .0001pt;text-align:left;text-indent:.5in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">SuperGen, Inc. (the
&#147;Company&#148;) hereby incorporates by reference in this registration statement the
following documents:</font></p>

<p align="left" style="margin:12.0pt 0in .0001pt;text-align:left;text-indent:.5in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">(a) The Company&#146;s Annual Report on Form&nbsp;10-K
for the fiscal year ended December 31, 2001, pursuant to Section 13 of the
Securities Exchange Act of 1934, as amended (the &#147;Exchange Act&#148;).</font></p>

<p align="left" style="margin:12.0pt 0in .0001pt;text-align:left;text-indent:.5in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">(b) All other reports filed pursuant to Section
13(a) or 15(d) of the Exchange Act since the end of the fiscal year covered by
the registrant document referred to in (a) above.</font></p>

<p align="left" style="margin:12.0pt 0in .0001pt;text-align:left;text-indent:.5in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">(c) The description of the Company&#146;s Common Stock
to be offered hereby is contained in the Company&#146;s Registration Statement on
Form 8-A filed with the Commission on January 18, 1996 pursuant to Section
12(g) of the Exchange Act, including any amendment or report filed for the
purpose of updating such description.</font></p>

<p align="left" style="margin:12.0pt 0in .0001pt;text-align:left;text-indent:.5in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">All documents
subsequently filed by the Company pursuant to Sections&nbsp;13(a), 13(c), 14
and 15(d) of the Exchange Act, prior to the filing of a post-effective
amendment to this registration statement which indicates that all securities
offered hereby have been sold or which deregisters all securities remaining
unsold, shall be deemed to be incorporated by reference in this registration
statement and to be a part hereof from the date of filing of such documents.</font></p>

<p align="left" style="font-family:'Times New Roman';margin:12.0pt 0in .0001pt;text-align:left;text-indent:0in;"><u><font size="2" face="Times New Roman" style="font-size:10.0pt;">Item 4</font></u><font size="2" style="font-size:10.0pt;">. <u>Description
of Securities</u></font></p>

<p align="left" style="margin:12.0pt 0in .0001pt;text-align:left;text-indent:.5in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">Not applicable.</font></p>

<p align="left" style="font-family:'Times New Roman';margin:12.0pt 0in .0001pt;text-align:left;text-indent:0in;"><u><font size="2" face="Times New Roman" style="font-size:10.0pt;">Item 5</font></u><font size="2" style="font-size:10.0pt;">. <u>Interests
of Named Experts and Counsel</u></font></p>

<p align="left" style="margin:12.0pt 0in .0001pt;text-align:left;text-indent:.5in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">Not applicable.</font></p>

<p align="left" style="font-family:'Times New Roman';margin:12.0pt 0in .0001pt;text-align:left;text-indent:0in;"><u><font size="2" face="Times New Roman" style="font-size:10.0pt;">Item 6</font></u><font size="2" style="font-size:10.0pt;">. <u>Indemnification
of Directors and Officers</u></font></p>

<p align="left" style="margin:12.0pt 0in .0001pt;text-align:left;text-indent:.5in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">The Company has adopted
provisions in its current Certificate of Incorporation which (i) eliminate the
personal liability of its directors to the Company for monetary damages to the
fullest extent permissible under Delaware law; and (ii) authorize the company
to indemnify its directors and officers to the fullest extent permitted by
law.&#160; Such limitation of liability does
not affect the availability of equitable remedies, such as injunctive relief or
rescission.&#160; The Company&#146;s Certificate
of Incorporation also includes a provision eliminating, to the fullest extent
permitted by Delaware law, the personal liability of its directors for monetary
damages for breach of fiduciary duty as a director.&#160; In addition, the Bylaws of the Company provide that it will be
required to indemnify its officers and directors to the maximum extent and in
the manner permitted by the Delaware General Corporation Law.</font></p>

<p align="left" style="margin:12.0pt 0in .0001pt;text-align:left;text-indent:.5in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">The Company has entered
into separate indemnification agreements with each of its officers, directors
and key employees that contain provisions which are in some respects broader
than the specific indemnification provisions contained in the Delaware General
Corporation Law.&#160; The indemnification </font></p>

<p align="center" style="margin:12.0pt 0in .0001pt;text-align:center;text-indent:0in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>

<p align="center" style="margin:12.0pt 0in .0001pt;text-align:center;text-indent:0in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">II-1</font></p>


<div align="left" style="margin:12.0pt 0in .0001pt;text-align:left;text-indent:0in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">

<hr size="2" width="100%" noshade color="gray" align="left">

</font></div>

<font size="2" face="Times New Roman" style="font-size:10.0pt;">
<!-- ZEQ.=1,SEQ=2,EFW="2076728",CP="SUPERGEN, INC.",DN="1",CHK=141715,FOLIO='',FILE="DISK012:[02PAL7.02PAL1547.EDGAR]S-8_1547.CHC",USER="DNICHOL",CD='Apr 19 13:31 2002' -->
<br clear="all" style="page-break-before:always;">
</font>

<p align="center" style="font-family:'Times New Roman';font-size:12.0pt;margin:12.0pt 0in .0001pt;text-align:center;text-indent:0in;">&nbsp;</p>

<p align="left" style="margin:12.0pt 0in .0001pt;text-align:left;text-indent:0in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">agreements may
require the Company, among other things, to indemnify such officers and
directors against certain liabilities that may arise by reason of their status
or service as directors or officers (other than liabilities arising from
willful misconduct of a culpable nature), to advance their expenses incurred as
a result of any proceeding against them, as to which they could be indemnified,
and to obtain director&#146;s and officer&#146;s insurance, if available on reasonable
terms.&#160; Insofar as indemnification for
liabilities arising under the Securities Act of 1933, as amended (the
&#147;Securities Act&#148;), may be permitted to directors, officers and controlling
persons of the Registrant pursuant to the foregoing provisions, or otherwise,
the Registrant has been advised that in the opinion of the Commission such
indemnification is against public policy as expressed in the Securities Act and
is, therefore, unenforceable.</font></p>

<p align="left" style="margin:12.0pt 0in .0001pt;text-align:left;text-indent:.5in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">At present, the Company
is not aware of any pending litigation involving a director, officer, employee
or agent of the Company where indemnification will be required or
permitted.&#160; The Company is not aware of
any threatened litigation or proceeding which may result in a claim for such
indemnification.</font></p>

<p align="left" style="font-family:'Times New Roman';margin:12.0pt 0in .0001pt;page-break-after:avoid;text-align:left;text-indent:0in;"><u><font size="2" face="Times New Roman" style="font-size:10.0pt;">Item 7</font></u><font size="2" style="font-size:10.0pt;">. <u>Exemption
From Registration Claimed</u></font></p>

<p align="left" style="margin:12.0pt 0in .0001pt;text-align:left;text-indent:.5in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">Not applicable.</font></p>

<p align="left" style="font-family:'Times New Roman';margin:12.0pt 0in .0001pt;text-align:left;text-indent:0in;"><u><font size="2" face="Times New Roman" style="font-size:10.0pt;">Item 8</font></u><font size="2" style="font-size:10.0pt;">. <u>Exhibits</u></font></p>

<table border="0" cellspacing="0" cellpadding="0" width="100%" style="border-collapse:collapse;font-family:'Times New Roman';width:100.0%;">
 <tr>
  <td width="5%" valign="top" style="padding:0in .7pt 0in .7pt;width:5.68%;">
  <p align="right" style="margin:0in 0in .0001pt;text-align:right;text-indent:0in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">4.1</font></p>
  </td>
  <td width="4%" valign="top" style="padding:0in .7pt 0in .7pt;width:4.42%;">
  <p align="left" style="margin:0in 0in .0001pt;text-align:left;text-indent:0in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">*</font></p>
  </td>
  <td width="89%" valign="top" style="padding:0in .7pt 0in .7pt;width:89.9%;">
  <p align="left" style="margin:0in 0in .0001pt;text-align:left;text-indent:0in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">1996 Directors Stock Option Plan (as amended effective February 7,
  2001).</font></p>
  </td>
 </tr>
 <tr>
  <td width="5%" valign="top" style="padding:0in .7pt 0in .7pt;width:5.68%;">
  <p align="right" style="font-size:12.0pt;margin:0in 0in .0001pt;text-align:right;text-indent:0in;">&nbsp;</p>
  </td>
  <td width="4%" valign="top" style="padding:0in .7pt 0in .7pt;width:4.42%;">
  <p align="left" style="font-size:12.0pt;margin:0in 0in .0001pt;text-align:left;text-indent:0in;">&nbsp;</p>
  </td>
  <td width="89%" valign="top" style="padding:0in .7pt 0in .7pt;width:89.9%;">
  <p align="left" style="font-size:12.0pt;margin:0in 0in .0001pt;text-align:left;text-indent:0in;">&nbsp;</p>
  </td>
 </tr>
 <tr>
  <td width="5%" valign="top" style="padding:0in .7pt 0in .7pt;width:5.68%;">
  <p align="right" style="margin:0in 0in .0001pt;text-align:right;text-indent:0in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">4.2</font></p>
  </td>
  <td width="4%" valign="top" style="padding:0in .7pt 0in .7pt;width:4.42%;">
  <p align="left" style="margin:0in 0in .0001pt;text-align:left;text-indent:0in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">**</font></p>
  </td>
  <td width="89%" valign="top" style="padding:0in .7pt 0in .7pt;width:89.9%;">
  <p align="left" style="margin:0in 0in .0001pt;text-align:left;text-indent:0in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">Form&nbsp;of Stock Option Agreement for use under the 1996 Directors
  Stock Option Plan.</font></p>
  </td>
 </tr>
 <tr>
  <td width="5%" valign="top" style="padding:0in .7pt 0in .7pt;width:5.68%;">
  <p align="right" style="font-size:12.0pt;margin:0in 0in .0001pt;text-align:right;text-indent:0in;">&nbsp;</p>
  </td>
  <td width="4%" valign="top" style="padding:0in .7pt 0in .7pt;width:4.42%;">
  <p align="left" style="font-size:12.0pt;margin:0in 0in .0001pt;text-align:left;text-indent:0in;">&nbsp;</p>
  </td>
  <td width="89%" valign="top" style="padding:0in .7pt 0in .7pt;width:89.9%;">
  <p align="left" style="font-size:12.0pt;margin:0in 0in .0001pt;text-align:left;text-indent:0in;">&nbsp;</p>
  </td>
 </tr>
 <tr>
  <td width="5%" valign="top" style="padding:0in .7pt 0in .7pt;width:5.68%;">
  <p align="right" style="margin:0in 0in .0001pt;text-align:right;text-indent:0in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">4.3</font></p>
  </td>
  <td width="4%" valign="top" style="padding:0in .7pt 0in .7pt;width:4.42%;">
  <p align="left" style="margin:0in 0in .0001pt;text-align:left;text-indent:0in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">*</font></p>
  </td>
  <td width="89%" valign="top" style="padding:0in .7pt 0in .7pt;width:89.9%;">
  <p align="left" style="margin:0in 0in .0001pt;text-align:left;text-indent:0in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">1998 Employee Stock Purchase Plan (as amended effective February 7,
  2001).</font></p>
  </td>
 </tr>
 <tr>
  <td width="5%" valign="top" style="padding:0in .7pt 0in .7pt;width:5.68%;">
  <p align="right" style="font-size:12.0pt;margin:0in 0in .0001pt;text-align:right;text-indent:0in;">&nbsp;</p>
  </td>
  <td width="4%" valign="top" style="padding:0in .7pt 0in .7pt;width:4.42%;">
  <p align="left" style="font-size:12.0pt;margin:0in 0in .0001pt;text-align:left;text-indent:0in;">&nbsp;</p>
  </td>
  <td width="89%" valign="top" style="padding:0in .7pt 0in .7pt;width:89.9%;">
  <p align="left" style="font-size:12.0pt;margin:0in 0in .0001pt;text-align:left;text-indent:0in;">&nbsp;</p>
  </td>
 </tr>
 <tr>
  <td width="5%" valign="top" style="padding:0in .7pt 0in .7pt;width:5.68%;">
  <p align="right" style="margin:0in 0in .0001pt;text-align:right;text-indent:0in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">5.1</font></p>
  </td>
  <td width="4%" valign="top" style="padding:0in .7pt 0in .7pt;width:4.42%;">
  <p style="font-size:1.0pt;margin:0in 0in .0001pt;text-indent:0in;">&nbsp;</p>
  </td>
  <td width="89%" valign="top" style="padding:0in .7pt 0in .7pt;width:89.9%;">
  <p style="margin:0in 0in .0001pt;text-indent:0in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">Opinion of Wilson Sonsini Goodrich &amp; Rosati,
  P.C., as to the legality of securities being registered.</font></p>
  </td>
 </tr>
 <tr>
  <td width="5%" valign="top" style="padding:0in .7pt 0in .7pt;width:5.68%;">
  <p align="right" style="font-size:11.0pt;margin:0in 0in .0001pt;text-align:right;text-indent:0in;">&nbsp;</p>
  </td>
  <td width="4%" valign="top" style="padding:0in .7pt 0in .7pt;width:4.42%;">
  <p style="font-size:11.0pt;margin:0in 0in .0001pt;text-indent:0in;">&nbsp;</p>
  </td>
  <td width="89%" valign="top" style="padding:0in .7pt 0in .7pt;width:89.9%;">
  <p style="font-size:11.0pt;margin:0in 0in .0001pt;text-indent:0in;">&nbsp;</p>
  </td>
 </tr>
 <tr>
  <td width="5%" valign="top" style="padding:0in .7pt 0in .7pt;width:5.68%;">
  <p align="right" style="margin:0in 0in .0001pt;text-align:right;text-indent:0in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">23.1</font></p>
  </td>
  <td width="4%" valign="top" style="padding:0in .7pt 0in .7pt;width:4.42%;">
  <p align="left" style="font-size:1.0pt;margin:0in 0in .0001pt;text-align:left;text-indent:0in;">&nbsp;</p>
  </td>
  <td width="89%" valign="top" style="padding:0in .7pt 0in .7pt;width:89.9%;">
  <p align="left" style="margin:0in 0in .0001pt;text-align:left;text-indent:0in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">Consent of Ernst &amp; Young LLP, Independent Auditors.</font></p>
  </td>
 </tr>
 <tr>
  <td width="5%" valign="top" style="padding:0in .7pt 0in .7pt;width:5.68%;">
  <p align="right" style="font-size:12.0pt;margin:0in 0in .0001pt;text-align:right;text-indent:0in;">&nbsp;</p>
  </td>
  <td width="4%" valign="top" style="padding:0in .7pt 0in .7pt;width:4.42%;">
  <p align="left" style="font-size:12.0pt;margin:0in 0in .0001pt;text-align:left;text-indent:0in;">&nbsp;</p>
  </td>
  <td width="89%" valign="top" style="padding:0in .7pt 0in .7pt;width:89.9%;">
  <p align="left" style="font-size:12.0pt;margin:0in 0in .0001pt;text-align:left;text-indent:0in;">&nbsp;</p>
  </td>
 </tr>
 <tr>
  <td width="5%" valign="top" style="padding:0in .7pt 0in .7pt;width:5.68%;">
  <p align="right" style="margin:0in 0in .0001pt;text-align:right;text-indent:0in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">23.2</font></p>
  </td>
  <td width="4%" valign="top" style="padding:0in .7pt 0in .7pt;width:4.42%;">
  <p align="left" style="font-size:1.0pt;margin:0in 0in .0001pt;text-align:left;text-indent:0in;">&nbsp;</p>
  </td>
  <td width="89%" valign="top" style="padding:0in .7pt 0in .7pt;width:89.9%;">
  <p align="left" style="margin:0in 0in .0001pt;text-align:left;text-indent:0in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">Consent of Counsel (contained in Exhibit 5.1).</font></p>
  </td>
 </tr>
 <tr>
  <td width="5%" valign="top" style="padding:0in .7pt 0in .7pt;width:5.68%;">
  <p align="right" style="font-size:12.0pt;margin:0in 0in .0001pt;text-align:right;text-indent:0in;">&nbsp;</p>
  </td>
  <td width="4%" valign="top" style="padding:0in .7pt 0in .7pt;width:4.42%;">
  <p align="left" style="font-size:12.0pt;margin:0in 0in .0001pt;text-align:left;text-indent:0in;">&nbsp;</p>
  </td>
  <td width="89%" valign="top" style="padding:0in .7pt 0in .7pt;width:89.9%;">
  <p align="left" style="font-size:12.0pt;margin:0in 0in .0001pt;text-align:left;text-indent:0in;">&nbsp;</p>
  </td>
 </tr>
 <tr>
  <td width="5%" valign="top" style="padding:0in .7pt 0in .7pt;width:5.68%;">
  <p align="right" style="margin:0in 0in .0001pt;text-align:right;text-indent:0in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">24.1</font></p>
  </td>
  <td width="4%" valign="top" style="padding:0in .7pt 0in .7pt;width:4.42%;">
  <p align="left" style="font-size:1.0pt;margin:0in 0in .0001pt;text-align:left;text-indent:0in;">&nbsp;</p>
  </td>
  <td width="89%" valign="top" style="padding:0in .7pt 0in .7pt;width:89.9%;">
  <p align="left" style="margin:0in 0in .0001pt;text-align:left;text-indent:0in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">Power of Attorney (see Page II-5)</font></p>
  </td>
 </tr>
</table>

<p align="left" style="margin:12.0pt 0in .0001pt;text-align:left;text-indent:0in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>

<p align="left" style="margin:12.0pt 0in .0001pt;text-align:left;text-indent:0in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">_________</font></p>

<p align="left" style="font-family:'Times New Roman';margin:12.0pt 0in .0001pt 27.0pt;text-align:left;text-indent:-27.0pt;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">*</font><font size="1" style="font-size:3.0pt;">&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; </font><font size="2" style="font-size:10.0pt;">Incorporated by reference to the appendix
filed with the Registrant&#146;s definitive Proxy Statement filed pursuant to
Section 14(a) with the Securities and Exchange Commission on April 17, 2001.</font></p>

<p align="left" style="font-family:'Times New Roman';margin:12.0pt 0in .0001pt 27.0pt;text-align:left;text-indent:-27.0pt;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">**</font><font size="1" style="font-size:3.0pt;">&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; </font><font size="2" style="font-size:10.0pt;">Incorporated by reference to the exhibit
filed with the Registrant&#146;s registration statement on Form SB-2 (file no.
333-476-LA) filed with the Securities and Exchange Commission on January 18,
1996.</font></p>

<p align="left" style="font-family:'Times New Roman';margin:12.0pt 0in .0001pt;text-align:left;text-indent:0in;"><u><font size="2" face="Times New Roman" style="font-size:10.0pt;">Item 9</font></u><font size="2" style="font-size:10.0pt;">. <u>Undertakings</u></font></p>

<p align="left" style="margin:12.0pt 0in .0001pt;text-align:left;text-indent:.5in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">(a) <u>Rule 415 Offering</u>. The undersigned
registrant hereby undertakes:</font></p>

<p align="left" style="margin:12.0pt 0in .0001pt .05pt;text-align:left;text-indent:71.95pt;"><font size="2" face="Times New Roman" style="font-size:10.0pt;"> (1) To file, during any period in which offers or
sales are being made, a post-effective amendment to this registration statement
to include any material information with respect to the</font></p>

<p align="center" style="margin:12.0pt 0in .0001pt;text-align:center;text-indent:0in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">II-2</font></p>


<div align="left" style="margin:12.0pt 0in .0001pt;text-align:left;text-indent:0in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">

<hr size="2" width="100%" noshade color="gray" align="left">

</font></div>

<font size="2" face="Times New Roman" style="font-size:10.0pt;">
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</font>

<p align="center" style="font-family:'Times New Roman';font-size:12.0pt;margin:12.0pt 0in .0001pt;text-align:center;text-indent:0in;">&nbsp;</p>

<p align="left" style="margin:12.0pt 0in .0001pt;text-align:left;text-indent:0in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&#160;plan of distribution not previously disclosed
in the registration statement or any material change to such information in the
registration statement.</font></p>

<p align="left" style="margin:12.0pt 0in .0001pt;text-align:left;text-indent:1.0in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">(2) That, for the purpose of determining any
liability under the Securities Act, each such post-effective amendment shall be
deemed to be a new registration statement relating to the securities offered
therein, and the offering of such securities at that time shall be deemed to be
the initial bona fide offering thereof.</font></p>

<p align="left" style="margin:12.0pt 0in .0001pt;text-align:left;text-indent:1.0in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">(3) To remove from registration by means of a
post-effective amendment any of the securities being registered which remain unsold
at the termination of the offering.</font></p>

<p align="left" style="margin:12.0pt 0in .0001pt;text-align:left;text-indent:.5in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">(b) <u>Filings incorporating subsequent Exchange
Act documents by reference</u>.</font></p>

<p align="left" style="margin:12.0pt 0in .0001pt;text-align:left;text-indent:.5in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">The undersigned
registrant hereby undertakes that, for purposes of determining any liability
under the Securities Act, each filing of the registrant&#146;s annual report
pursuant to section 13(a) or section 15(d) of the Exchange Act (and, where
applicable, each filing of an employee benefit plan&#146;s annual report pursuant to
section 15(d) of the Exchange Act) that is incorporated by reference in the registration
statement shall be deemed to be a new registration statement relating to the
securities offered therein, and the offering of such securities at that time
shall be deemed to be the initial bona fide offering thereof.</font></p>

<p align="left" style="margin:12.0pt 0in .0001pt;text-align:left;text-indent:.5in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">(c) <u>Request for acceleration of effective date
or filing of registration statement on Form&nbsp;S-8</u>.</font></p>

<p align="left" style="margin:12.0pt 0in .0001pt;text-align:left;text-indent:.5in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">Insofar as
indemnification for liabilities arising under the Securities Act may be
permitted to directors, officers and controlling persons of the registrant
pursuant to the foregoing provisions, or otherwise, the registrant has been
advised that in the opinion of the Securities and Exchange Commission such
indemnification is against public policy as expressed in the Securities Act and
is, therefore, unenforceable.&#160; In the
event that a claim for indemnification against such liabilities (other than the
payment by the registrant of expenses incurred or paid by a director, officer
or controlling person of the registrant in the successful defense of any
action, suit or proceeding) is asserted by such director, officer or
controlling person in connection with the securities being registered, the
registrant will, unless in the opinion of its counsel the matter has been
settled by controlling precedent, submit to a court of appropriate jurisdiction
the question whether such indemnification by it is against public policy as
expressed in the Securities Act and will be governed by the final adjudication
of such issue.</font></p>

<p align="center" style="margin:12.0pt 0in .0001pt;text-align:center;text-indent:0in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">II-3</font></p>


<div align="left" style="margin:12.0pt 0in .0001pt;text-align:left;text-indent:0in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">

<hr size="2" width="100%" noshade color="gray" align="left">

</font></div>

<font size="2" face="Times New Roman" style="font-size:10.0pt;">
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<p align="center" style="font-family:'Times New Roman';font-size:12.0pt;margin:12.0pt 0in .0001pt;text-align:center;text-indent:0in;">&nbsp;</p>

<p align="center" style="margin:12.0pt 0in .0001pt;text-align:center;text-indent:0in;"><b><font size="2" face="Times New Roman" style="font-size:10.0pt;font-weight:bold;">SIGNATURES</font></b></p>

<p align="left" style="margin:12.0pt 0in .0001pt;text-align:left;text-indent:.5in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">Pursuant to the
requirements of the Securities Act of 1933, the registrant certifies that it
has reasonable grounds to believe that it meets all of the requirements for
filing on Form&nbsp;S-8 and has duly caused this registration statement to be
signed on its behalf by the undersigned, thereunto duly authorized, in the City
of Dublin, State of California, on April 19, 2002.</font></p>

<table border="0" cellspacing="0" cellpadding="0" width="100%" style="border-collapse:collapse;font-family:'Times New Roman';width:100.0%;">
 <tr>
  <td width="53%" colspan="2" valign="top" style="padding:0in .7pt 0in .7pt;width:53.32%;">
  <p align="left" style="font-size:12.0pt;margin:0in 0in .0001pt;text-align:left;text-indent:0in;">&nbsp;</p>
  </td>
  <td width="46%" valign="top" style="padding:0in .7pt 0in .7pt;width:46.68%;">
  <p align="left" style="font-size:12.0pt;margin:0in 0in .0001pt;text-align:left;text-indent:0in;">&nbsp;</p>
  </td>
 </tr>
 <tr>
  <td width="53%" colspan="2" valign="top" style="padding:0in .7pt 0in .7pt;width:53.32%;">
  <p style="font-size:1.0pt;margin:0in 0in .0001pt;text-align:justify;text-indent:.5in;">&nbsp;</p>
  </td>
  <td width="46%" valign="top" style="padding:0in .7pt 0in .7pt;width:46.68%;">
  <p align="left" style="margin:0in 0in .0001pt;text-align:left;text-indent:0in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">SUPERGEN, INC.</font></p>
  </td>
 </tr>
 <tr>
  <td width="100%" colspan="3" valign="top" style="padding:0in .7pt 0in .7pt;width:100.0%;">
  <p align="left" style="font-size:12.0pt;margin:0in 0in .0001pt;text-align:left;text-indent:0in;">&nbsp;</p>
  </td>
 </tr>
 <tr>
  <td width="47%" valign="top" style="padding:0in .7pt 0in .7pt;width:47.78%;">
  <p align="left" style="font-size:1.0pt;margin:0in 0in .0001pt;text-align:left;text-indent:0in;">&nbsp;</p>
  </td>
  <td width="5%" valign="top" style="padding:0in .7pt 0in .7pt;width:5.54%;">
  <p align="left" style="margin:0in 0in .0001pt;text-align:left;text-indent:0in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">By:</font></p>
  </td>
  <td width="46%" valign="top" style="border:none;border-bottom:solid windowtext .5pt;padding:0in .7pt 0in .7pt;width:46.68%;">
  <p align="left" style="margin:0in 0in .0001pt;text-align:left;text-indent:0in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;text-transform:uppercase;">/s/ JOSEPH RUBINFELD</font></p>
  </td>
 </tr>
 <tr>
  <td width="47%" valign="top" style="padding:0in .7pt 0in .7pt;width:47.78%;">
  <p align="left" style="font-size:1.0pt;margin:0in 0in .0001pt;text-align:left;text-indent:0in;">&nbsp;</p>
  </td>
  <td width="5%" valign="top" style="padding:0in .7pt 0in .7pt;width:5.54%;">
  <p align="left" style="font-size:1.0pt;margin:0in 0in .0001pt;text-align:left;text-indent:0in;">&nbsp;</p>
  </td>
  <td width="46%" valign="top" style="padding:0in .7pt 0in .7pt;width:46.68%;">
  <p align="left" style="margin:0in 0in .0001pt;text-align:left;text-indent:0in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">Joseph Rubinfeld, Ph.D.</font></p>
  </td>
 </tr>
 <tr>
  <td width="47%" valign="top" style="padding:0in .7pt 0in .7pt;width:47.78%;">
  <p align="left" style="font-size:1.0pt;margin:0in 0in .0001pt;text-align:left;text-indent:0in;">&nbsp;</p>
  </td>
  <td width="5%" valign="top" style="padding:0in .7pt 0in .7pt;width:5.54%;">
  <p align="left" style="font-size:1.0pt;margin:0in 0in .0001pt;text-align:left;text-indent:0in;">&nbsp;</p>
  </td>
  <td width="46%" valign="top" style="padding:0in .7pt 0in .7pt;width:46.68%;">
  <p align="left" style="margin:0in 0in .0001pt;text-align:left;text-indent:0in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">Chief Executive Officer, President and Director</font></p>
  </td>
 </tr>
</table>

<p align="left" style="margin:0in 0in .0001pt 3.0in;text-align:left;text-indent:0in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>

<p align="left" style="margin:0in 0in .0001pt 3.0in;text-align:left;text-indent:0in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>

<p align="left" style="margin:0in 0in .0001pt;text-align:left;text-indent:0in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>

<p align="center" style="margin:12.0pt 0in .0001pt;text-align:center;text-indent:0in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>

<p align="center" style="margin:12.0pt 0in .0001pt;text-align:center;text-indent:0in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">II-4</font></p>


<div align="left" style="margin:12.0pt 0in .0001pt;text-align:left;text-indent:0in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">

<hr size="2" width="100%" noshade color="gray" align="left">

</font></div>

<font size="2" face="Times New Roman" style="font-size:10.0pt;">
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<p align="center" style="font-family:'Times New Roman';font-size:12.0pt;margin:12.0pt 0in .0001pt;text-align:center;text-indent:0in;">&nbsp;</p>

<p align="center" style="margin:12.0pt 0in .0001pt;text-align:center;text-indent:0in;"><b><font size="2" face="Times New Roman" style="font-size:10.0pt;font-weight:bold;">POWER OF ATTORNEY</font></b></p>

<p align="left" style="margin:12.0pt 0in .0001pt;text-align:left;text-indent:.5in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">KNOW ALL PERSONS BY THESE
PRESENTS, that each person whose signature appears below constitutes and
appoints Joseph Rubinfeld, his attorney-in-fact, for him in any and all
capacities, to sign any amendments to this registration statement on
Form&nbsp;S-8, and to file the same, with exhibits thereto and other documents
in connection therewith, with the Securities and Exchange Commission, hereby
ratifying and confirming all that said attorney-in-fact, or his substitute or
substitutes, may do or cause to be done by virtue hereof.</font></p>

<p align="left" style="margin:12.0pt 0in .0001pt;text-align:left;text-indent:.5in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">Pursuant to the
requirements of the Securities Act of 1933, this registration statement has
been signed below by the following persons in the capacities and on the dates
indicated.</font></p>

<p align="left" style="margin:12.0pt 0in .0001pt;text-align:left;text-indent:.5in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>

<table border="0" cellspacing="0" cellpadding="0" width="100%" style="border-collapse:collapse;font-family:'Times New Roman';width:100.0%;">
 <tr>
  <td width="31%" valign="bottom" style="padding:0in 0in 0in 0in;width:31.12%;">
  <div style="border:none;border-bottom:solid windowtext .25pt;padding:0in 0in 1.0pt 0in;">
  <p align="center" style="border:none;margin:12.0pt 0in .0001pt;padding:0in;text-align:center;text-indent:0in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">Signature</font></p>
  </div>
  </td>
  <td width="2%" valign="top" style="padding:0in 0in 0in 0in;width:2.4%;">
  <p align="left" style="font-size:1.0pt;margin:12.0pt 0in .0001pt;text-align:left;text-indent:0in;">&nbsp;</p>
  </td>
  <td width="41%" valign="bottom" style="padding:0in 0in 0in 0in;width:41.98%;">
  <div style="border:none;border-bottom:solid windowtext .25pt;padding:0in 0in 1.0pt 0in;">
  <p align="center" style="border:none;margin:12.0pt 0in .0001pt;padding:0in;text-align:center;text-indent:0in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">Title</font></p>
  </div>
  </td>
  <td width="2%" valign="top" style="padding:0in 0in 0in 0in;width:2.4%;">
  <p align="left" style="font-size:1.0pt;margin:12.0pt 0in .0001pt;text-align:left;text-indent:0in;">&nbsp;</p>
  </td>
  <td width="22%" valign="bottom" style="padding:0in 0in 0in 0in;width:22.08%;">
  <div style="border:none;border-bottom:solid windowtext .25pt;padding:0in 0in 1.0pt 0in;">
  <p align="center" style="border:none;margin:12.0pt 0in .0001pt;padding:0in;text-align:center;text-indent:0in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">Date</font></p>
  </div>
  </td>
 </tr>
 <tr>
  <td width="31%" valign="top" style="padding:0in 0in 0in 0in;width:31.12%;">
  <p style="margin:12.0pt 0in .0001pt;text-align:justify;text-indent:0in;"><font size="2" face="Times New Roman" style="font-size:1.0pt;">&nbsp;</font></p>
  <p style="margin:0in 0in .0001pt;text-align:justify;text-indent:0in;"><u><font size="2" face="Times New Roman" style="font-size:10.0pt;text-transform:uppercase;">/s/ JOSEPH RUBINFELD&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; </font></u></p>
  <p align="center" style="margin:0in 0in .0001pt;text-align:center;text-indent:0in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">(Joseph Rubinfeld)</font></p>
  </td>
  <td width="2%" valign="top" style="padding:0in 0in 0in 0in;width:2.4%;">
  <p align="left" style="font-size:1.0pt;margin:12.0pt 0in .0001pt;text-align:left;text-indent:0in;">&nbsp;</p>
  </td>
  <td width="41%" valign="top" style="padding:0in 0in 0in 0in;width:41.98%;">
  <p align="left" style="margin:12.0pt 0in .0001pt;text-align:left;text-indent:0in;"><font size="2" face="Times New Roman" style="font-size:1.0pt;">&nbsp;</font></p>
  <p align="left" style="margin:0in 0in .0001pt;text-align:left;text-indent:0in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">Chief Executive Officer, President and Director <i><font style="font-style:italic;">(Principal Executive Officer)</font></i></font></p>
  </td>
  <td width="2%" valign="top" style="padding:0in 0in 0in 0in;width:2.4%;">
  <p align="center" style="font-size:1.0pt;margin:12.0pt 0in .0001pt;text-align:center;text-indent:0in;">&nbsp;</p>
  </td>
  <td width="22%" valign="top" style="padding:0in 0in 0in 0in;width:22.08%;">
  <p align="center" style="margin:12.0pt 0in .0001pt;text-align:center;text-indent:0in;"><font size="2" face="Times New Roman" style="font-size:1.0pt;">&nbsp;</font></p>
  <p align="center" style="margin:0in 0in .0001pt;text-align:center;text-indent:0in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">April 19, 2002</font></p>
  </td>
 </tr>
 <tr>
  <td width="31%" valign="top" style="padding:0in 0in 0in 0in;width:31.12%;">
  <p style="margin:12.0pt 0in .0001pt;text-align:justify;text-indent:0in;"><font size="2" face="Times New Roman" style="font-size:1.0pt;">&nbsp;</font></p>
  <p align="left" style="margin:0in 0in .0001pt;text-align:left;text-indent:0in;"><u><font size="2" face="Times New Roman" style="font-size:10.0pt;text-transform:uppercase;">/s/
  EDWARD L. JACOBS&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; </font></u></p>
  <p align="center" style="margin:0in 0in .0001pt;text-align:center;text-indent:0in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">(Edward L. Jacobs)</font></p>
  </td>
  <td width="2%" valign="top" style="padding:0in 0in 0in 0in;width:2.4%;">
  <p align="left" style="font-size:1.0pt;margin:12.0pt 0in .0001pt;text-align:left;text-indent:0in;">&nbsp;</p>
  </td>
  <td width="41%" valign="top" style="padding:0in 0in 0in 0in;width:41.98%;">
  <p align="left" style="margin:12.0pt 0in .0001pt;text-align:left;text-indent:0in;"><font size="2" face="Times New Roman" style="font-size:1.0pt;">&nbsp;</font></p>
  <p align="left" style="margin:0in 0in .0001pt;text-align:left;text-indent:0in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">Chief Business Officer/Chief Financial Officer <i><font style="font-style:italic;">(Principal Financial and Accounting
  Officer)</font></i> </font></p>
  </td>
  <td width="2%" valign="top" style="padding:0in 0in 0in 0in;width:2.4%;">
  <p align="center" style="font-size:1.0pt;margin:12.0pt 0in .0001pt;text-align:center;text-indent:0in;">&nbsp;</p>
  </td>
  <td width="22%" valign="top" style="padding:0in 0in 0in 0in;width:22.08%;">
  <p align="center" style="margin:12.0pt 0in .0001pt;text-align:center;text-indent:0in;"><font size="2" face="Times New Roman" style="font-size:1.0pt;">&nbsp;</font></p>
  <p align="center" style="margin:0in 0in .0001pt;text-align:center;text-indent:0in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">April 19, 2002</font></p>
  </td>
 </tr>
 <tr>
  <td width="31%" valign="top" style="padding:0in 0in 0in 0in;width:31.12%;">
  <p style="margin:12.0pt 0in .0001pt;text-align:justify;text-indent:0in;"><font size="2" face="Times New Roman" style="font-size:1.0pt;">&nbsp;</font></p>
  <p align="left" style="margin:0in 0in .0001pt;text-align:left;text-indent:0in;"><u><font size="2" face="Times New Roman" style="font-size:10.0pt;text-transform:uppercase;">/s/
  DENIS BURGER&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; </font></u></p>
  <p align="center" style="margin:0in 0in .0001pt;text-align:center;text-indent:0in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">(Denis Burger)</font></p>
  </td>
  <td width="2%" valign="top" style="padding:0in 0in 0in 0in;width:2.4%;">
  <p align="left" style="font-size:1.0pt;margin:12.0pt 0in .0001pt;text-align:left;text-indent:0in;">&nbsp;</p>
  </td>
  <td width="41%" valign="top" style="padding:0in 0in 0in 0in;width:41.98%;">
  <p align="left" style="margin:12.0pt 0in .0001pt;text-align:left;text-indent:0in;"><font size="2" face="Times New Roman" style="font-size:1.0pt;">&nbsp;</font></p>
  <p align="left" style="margin:0in 0in .0001pt;text-align:left;text-indent:0in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">Director</font></p>
  </td>
  <td width="2%" valign="top" style="padding:0in 0in 0in 0in;width:2.4%;">
  <p align="center" style="font-size:1.0pt;margin:12.0pt 0in .0001pt;text-align:center;text-indent:0in;">&nbsp;</p>
  </td>
  <td width="22%" valign="top" style="padding:0in 0in 0in 0in;width:22.08%;">
  <p align="center" style="margin:12.0pt 0in .0001pt;text-align:center;text-indent:0in;"><font size="2" face="Times New Roman" style="font-size:1.0pt;">&nbsp;</font></p>
  <p align="center" style="margin:0in 0in .0001pt;text-align:center;text-indent:0in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">April 19, 2002</font></p>
  </td>
 </tr>
 <tr>
  <td width="31%" valign="top" style="padding:0in 0in 0in 0in;width:31.12%;">
  <p style="margin:12.0pt 0in .0001pt;text-align:justify;text-indent:0in;"><font size="2" face="Times New Roman" style="font-size:1.0pt;">&nbsp;</font></p>
  <p align="left" style="margin:0in 0in .0001pt;text-align:left;text-indent:0in;"><u><font size="2" face="Times New Roman" style="font-size:10.0pt;text-transform:uppercase;">/s/
  THOMAS V. GIRARDI&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; </font></u></p>
  <p align="center" style="margin:0in 0in .0001pt;text-align:center;text-indent:0in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">(Thomas V. Girardi)</font></p>
  </td>
  <td width="2%" valign="top" style="padding:0in 0in 0in 0in;width:2.4%;">
  <p align="left" style="font-size:1.0pt;margin:12.0pt 0in .0001pt;text-align:left;text-indent:0in;">&nbsp;</p>
  </td>
  <td width="41%" valign="top" style="padding:0in 0in 0in 0in;width:41.98%;">
  <p align="left" style="margin:12.0pt 0in .0001pt;text-align:left;text-indent:0in;"><font size="2" face="Times New Roman" style="font-size:1.0pt;">&nbsp;</font></p>
  <p align="left" style="margin:0in 0in .0001pt;text-align:left;text-indent:0in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">Director</font></p>
  </td>
  <td width="2%" valign="top" style="padding:0in 0in 0in 0in;width:2.4%;">
  <p align="center" style="font-size:1.0pt;margin:12.0pt 0in .0001pt;text-align:center;text-indent:0in;">&nbsp;</p>
  </td>
  <td width="22%" valign="top" style="padding:0in 0in 0in 0in;width:22.08%;">
  <p align="center" style="margin:12.0pt 0in .0001pt;text-align:center;text-indent:0in;"><font size="2" face="Times New Roman" style="font-size:1.0pt;">&nbsp;</font></p>
  <p align="center" style="margin:0in 0in .0001pt;text-align:center;text-indent:0in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">April 19, 2002</font></p>
  </td>
 </tr>
 <tr>
  <td width="31%" valign="top" style="padding:0in 0in 0in 0in;width:31.12%;">
  <p style="margin:12.0pt 0in .0001pt;text-align:justify;text-indent:0in;"><font size="2" face="Times New Roman" style="font-size:1.0pt;">&nbsp;</font></p>
  <p align="left" style="margin:0in 0in .0001pt;text-align:left;text-indent:0in;"><u><font size="2" face="Times New Roman" style="font-size:10.0pt;text-transform:uppercase;">/s/
  WALTER J. LACK</font></u><u><font size="2" style="font-size:10.0pt;">&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; </font></u></p>
  <p align="center" style="margin:0in 0in .0001pt;text-align:center;text-indent:0in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">(Walter J. Lack)</font></p>
  </td>
  <td width="2%" valign="top" style="padding:0in 0in 0in 0in;width:2.4%;">
  <p align="left" style="font-size:1.0pt;margin:12.0pt 0in .0001pt;text-align:left;text-indent:0in;">&nbsp;</p>
  </td>
  <td width="41%" valign="top" style="padding:0in 0in 0in 0in;width:41.98%;">
  <p align="left" style="margin:12.0pt 0in .0001pt;text-align:left;text-indent:0in;"><font size="2" face="Times New Roman" style="font-size:1.0pt;">&nbsp;</font></p>
  <p align="left" style="margin:0in 0in .0001pt;text-align:left;text-indent:0in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">Director</font></p>
  </td>
  <td width="2%" valign="top" style="padding:0in 0in 0in 0in;width:2.4%;">
  <p align="center" style="font-size:1.0pt;margin:12.0pt 0in .0001pt;text-align:center;text-indent:0in;">&nbsp;</p>
  </td>
  <td width="22%" valign="top" style="padding:0in 0in 0in 0in;width:22.08%;">
  <p align="center" style="margin:12.0pt 0in .0001pt;text-align:center;text-indent:0in;"><font size="2" face="Times New Roman" style="font-size:1.0pt;">&nbsp;</font></p>
  <p align="center" style="margin:0in 0in .0001pt;text-align:center;text-indent:0in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">April 19, 2002</font></p>
  </td>
 </tr>
 <tr>
  <td width="31%" valign="top" style="padding:0in 0in 0in 0in;width:31.12%;">
  <p style="margin:12.0pt 0in .0001pt;text-align:justify;text-indent:0in;"><font size="2" face="Times New Roman" style="font-size:1.0pt;">&nbsp;</font></p>
  <p align="left" style="margin:0in 0in .0001pt;text-align:left;text-indent:0in;"><u><font size="2" face="Times New Roman" style="font-size:10.0pt;text-transform:uppercase;">/s/
  JAMES S. J. MANUSO</font></u><u><font size="2" style="font-size:10.0pt;">&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; </font></u></p>
  <p align="center" style="margin:0in 0in .0001pt 160.5pt;text-align:center;text-indent:-160.5pt;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">(James S. J. Manuso)</font></p>
  </td>
  <td width="2%" valign="top" style="padding:0in 0in 0in 0in;width:2.4%;">
  <p align="left" style="font-size:1.0pt;margin:12.0pt 0in .0001pt;text-align:left;text-indent:0in;">&nbsp;</p>
  </td>
  <td width="41%" valign="top" style="padding:0in 0in 0in 0in;width:41.98%;">
  <p align="left" style="margin:12.0pt 0in .0001pt;text-align:left;text-indent:0in;"><font size="2" face="Times New Roman" style="font-size:1.0pt;">&nbsp;</font></p>
  <p align="left" style="margin:0in 0in .0001pt;text-align:left;text-indent:0in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">Director</font></p>
  </td>
  <td width="2%" valign="top" style="padding:0in 0in 0in 0in;width:2.4%;">
  <p align="center" style="font-size:1.0pt;margin:12.0pt 0in .0001pt;text-align:center;text-indent:0in;">&nbsp;</p>
  </td>
  <td width="22%" valign="top" style="padding:0in 0in 0in 0in;width:22.08%;">
  <p align="center" style="margin:12.0pt 0in .0001pt;text-align:center;text-indent:0in;"><font size="2" face="Times New Roman" style="font-size:1.0pt;">&nbsp;</font></p>
  <p align="center" style="margin:0in 0in .0001pt;text-align:center;text-indent:0in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">April 19, 2002</font></p>
  </td>
 </tr>
 <tr>
  <td width="31%" valign="top" style="padding:0in 0in 0in 0in;width:31.12%;">
  <p style="margin:12.0pt 0in .0001pt 6.4pt;text-align:justify;text-indent:0in;"><font size="2" face="Times New Roman" style="font-size:1.0pt;">&nbsp;</font></p>
  <p align="left" style="margin:0in 0in .0001pt;text-align:left;text-indent:0in;"><u><font size="2" face="Times New Roman" style="font-size:10.0pt;text-transform:uppercase;">/s/
  DANIEL ZURR&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; </font></u></p>
  <p align="center" style="margin:0in 0in .0001pt;text-align:center;text-indent:0in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">(Daniel Zurr)</font></p>
  </td>
  <td width="2%" valign="top" style="padding:0in 0in 0in 0in;width:2.4%;">
  <p align="left" style="font-size:1.0pt;margin:12.0pt 0in .0001pt;text-align:left;text-indent:0in;">&nbsp;</p>
  </td>
  <td width="41%" valign="top" style="padding:0in 0in 0in 0in;width:41.98%;">
  <p align="left" style="margin:12.0pt 0in .0001pt;text-align:left;text-indent:0in;"><font size="2" face="Times New Roman" style="font-size:1.0pt;">&nbsp;</font></p>
  <p align="left" style="margin:0in 0in .0001pt;text-align:left;text-indent:0in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">Director</font></p>
  </td>
  <td width="2%" valign="top" style="padding:0in 0in 0in 0in;width:2.4%;">
  <p align="center" style="font-size:1.0pt;margin:12.0pt 0in .0001pt;text-align:center;text-indent:0in;">&nbsp;</p>
  </td>
  <td width="22%" valign="top" style="padding:0in 0in 0in 0in;width:22.08%;">
  <p align="center" style="margin:12.0pt 0in .0001pt;text-align:center;text-indent:0in;"><font size="2" face="Times New Roman" style="font-size:1.0pt;">&nbsp;</font></p>
  <p align="center" style="margin:0in 0in .0001pt;text-align:center;text-indent:0in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">April 19, 2002</font></p>
  </td>
 </tr>
</table>

<p align="left" style="margin:12.0pt 0in .0001pt;text-align:left;text-indent:48.0pt;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>

<p align="center" style="margin:12.0pt 0in .0001pt;text-align:center;text-indent:0in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">II-5</font></p>


<div align="left" style="margin:12.0pt 0in .0001pt;text-align:left;text-indent:0in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">

<hr size="2" width="100%" noshade color="gray" align="left">

</font></div>

<font size="2" face="Times New Roman" style="font-size:10.0pt;">
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<p align="center" style="font-family:'Times New Roman';font-size:12.0pt;margin:12.0pt 0in .0001pt;text-align:center;text-indent:0in;">&nbsp;</p>

<p align="center" style="margin:12.0pt 0in .0001pt;text-align:center;text-indent:0in;"><b><font size="2" face="Times New Roman" style="font-size:10.0pt;font-weight:bold;">SUPERGEN, INC.</font></b></p>

<p align="center" style="margin:12.0pt 0in .0001pt;text-align:center;text-indent:0in;"><b><font size="2" face="Times New Roman" style="font-size:10.0pt;font-weight:bold;">REGISTRATION STATEMENT ON FORM S-8</font></b></p>

<p align="center" style="margin:12.0pt 0in .0001pt;text-align:center;text-indent:0in;"><b><font size="2" face="Times New Roman" style="font-size:10.0pt;font-weight:bold;">EXHIBIT INDEX</font></b></p>

<table border="0" cellspacing="0" cellpadding="0" width="87%" style="border-collapse:collapse;font-family:'Times New Roman';margin-left:.4pt;width:87.64%;">
 <tr>
  <td width="64" colspan="2" valign="bottom" style="padding:0in 0in 0in 0in;width:48.0pt;">
  <p align="left" style="margin:0in 0in .0001pt;text-align:left;text-indent:0in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">Exhibit</font></p>
  <p align="left" style="margin:0in 11.5pt .0001pt 0in;text-align:left;text-indent:0in;"><u><font size="2" face="Times New Roman" style="font-size:10.0pt;">Number</font></u></p>
  </td>
  <td width="568" colspan="2" valign="bottom" style="padding:0in 0in 0in 0in;width:425.95pt;">
  <p align="left" style="margin:0in 0in .0001pt;text-align:left;text-indent:0in;"><u><font size="2" face="Times New Roman" style="font-size:10.0pt;">Description</font></u></p>
  </td>
 </tr>
 <tr>
  <td width="40" valign="top" style="padding:0in .7pt 0in .7pt;width:30.0pt;">
  <p align="right" style="font-size:12.0pt;margin:0in 0in .0001pt;text-align:right;text-indent:0in;">&nbsp;</p>
  </td>
  <td width="24" valign="top" style="padding:0in .7pt 0in .7pt;width:.25in;">
  <p align="left" style="font-size:12.0pt;margin:0in 0in .0001pt;text-align:left;text-indent:0in;">&nbsp;</p>
  </td>
  <td width="545" valign="top" style="padding:0in .7pt 0in .7pt;width:408.4pt;">
  <p align="left" style="font-size:12.0pt;margin:0in 0in .0001pt;text-align:left;text-indent:0in;">&nbsp;</p>
  </td>
  <td width="23" style="border:none;font-size:12.0pt;padding:0in 0in 0in 0in;"><p style="margin:12.0pt 0in .0001pt;text-align:justify;text-indent:.5in;">&nbsp;</p></td>
 </tr>
 <tr>
  <td width="40" valign="top" style="padding:0in .7pt 0in .7pt;width:30.0pt;">
  <p align="right" style="margin:0in 0in .0001pt;text-align:right;text-indent:0in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">4.1</font></p>
  </td>
  <td width="24" valign="top" style="padding:0in .7pt 0in .7pt;width:.25in;">
  <p align="left" style="margin:0in 0in .0001pt;text-align:left;text-indent:0in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">*</font></p>
  </td>
  <td width="545" valign="top" style="padding:0in .7pt 0in .7pt;width:408.4pt;">
  <p align="left" style="margin:0in 0in .0001pt;text-align:left;text-indent:0in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">1996 Directors Stock Option Plan (as amended effective February 7,
  2001).</font></p>
  </td>
  <td width="23" style="border:none;font-size:1.0pt;padding:0in 0in 0in 0in;"><p style="margin:12.0pt 0in .0001pt;text-align:justify;text-indent:.5in;">&nbsp;</p></td>
 </tr>
 <tr>
  <td width="40" valign="top" style="padding:0in .7pt 0in .7pt;width:30.0pt;">
  <p align="right" style="font-size:12.0pt;margin:0in 0in .0001pt;text-align:right;text-indent:0in;">&nbsp;</p>
  </td>
  <td width="24" valign="top" style="padding:0in .7pt 0in .7pt;width:.25in;">
  <p align="left" style="font-size:12.0pt;margin:0in 0in .0001pt;text-align:left;text-indent:0in;">&nbsp;</p>
  </td>
  <td width="545" valign="top" style="padding:0in .7pt 0in .7pt;width:408.4pt;">
  <p align="left" style="font-size:12.0pt;margin:0in 0in .0001pt;text-align:left;text-indent:0in;">&nbsp;</p>
  </td>
  <td width="23" style="border:none;font-size:12.0pt;padding:0in 0in 0in 0in;"><p style="margin:12.0pt 0in .0001pt;text-align:justify;text-indent:.5in;">&nbsp;</p></td>
 </tr>
 <tr>
  <td width="40" valign="top" style="padding:0in .7pt 0in .7pt;width:30.0pt;">
  <p align="right" style="margin:0in 0in .0001pt;text-align:right;text-indent:0in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">4.2</font></p>
  </td>
  <td width="24" valign="top" style="padding:0in .7pt 0in .7pt;width:.25in;">
  <p align="left" style="margin:0in 0in .0001pt;text-align:left;text-indent:0in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">**</font></p>
  </td>
  <td width="545" valign="top" style="padding:0in .7pt 0in .7pt;width:408.4pt;">
  <p align="left" style="margin:0in 0in .0001pt;text-align:left;text-indent:0in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">Form&nbsp;of Stock Option Agreement for use under the 1996 Directors
  Stock Option Plan.</font></p>
  </td>
  <td width="23" style="border:none;font-size:1.0pt;padding:0in 0in 0in 0in;"><p style="margin:12.0pt 0in .0001pt;text-align:justify;text-indent:.5in;">&nbsp;</p></td>
 </tr>
 <tr>
  <td width="40" valign="top" style="padding:0in .7pt 0in .7pt;width:30.0pt;">
  <p align="right" style="font-size:12.0pt;margin:0in 0in .0001pt;text-align:right;text-indent:0in;">&nbsp;</p>
  </td>
  <td width="24" valign="top" style="padding:0in .7pt 0in .7pt;width:.25in;">
  <p align="left" style="font-size:12.0pt;margin:0in 0in .0001pt;text-align:left;text-indent:0in;">&nbsp;</p>
  </td>
  <td width="545" valign="top" style="padding:0in .7pt 0in .7pt;width:408.4pt;">
  <p align="left" style="font-size:12.0pt;margin:0in 0in .0001pt;text-align:left;text-indent:0in;">&nbsp;</p>
  </td>
  <td width="23" style="border:none;font-size:12.0pt;padding:0in 0in 0in 0in;"><p style="margin:12.0pt 0in .0001pt;text-align:justify;text-indent:.5in;">&nbsp;</p></td>
 </tr>
 <tr>
  <td width="40" valign="top" style="padding:0in .7pt 0in .7pt;width:30.0pt;">
  <p align="right" style="margin:0in 0in .0001pt;text-align:right;text-indent:0in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">4.3</font></p>
  </td>
  <td width="24" valign="top" style="padding:0in .7pt 0in .7pt;width:.25in;">
  <p align="left" style="margin:0in 0in .0001pt;text-align:left;text-indent:0in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">*</font></p>
  </td>
  <td width="545" valign="top" style="padding:0in .7pt 0in .7pt;width:408.4pt;">
  <p align="left" style="margin:0in 0in .0001pt;text-align:left;text-indent:0in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">1998 Employee Stock Purchase Plan (as amended effective February 7,
  2001).</font></p>
  </td>
  <td width="23" style="border:none;font-size:1.0pt;padding:0in 0in 0in 0in;"><p style="margin:12.0pt 0in .0001pt;text-align:justify;text-indent:.5in;">&nbsp;</p></td>
 </tr>
 <tr>
  <td width="40" valign="top" style="padding:0in .7pt 0in .7pt;width:30.0pt;">
  <p align="right" style="font-size:12.0pt;margin:0in 0in .0001pt;text-align:right;text-indent:0in;">&nbsp;</p>
  </td>
  <td width="24" valign="top" style="padding:0in .7pt 0in .7pt;width:.25in;">
  <p align="left" style="font-size:12.0pt;margin:0in 0in .0001pt;text-align:left;text-indent:0in;">&nbsp;</p>
  </td>
  <td width="545" valign="top" style="padding:0in .7pt 0in .7pt;width:408.4pt;">
  <p align="left" style="font-size:12.0pt;margin:0in 0in .0001pt;text-align:left;text-indent:0in;">&nbsp;</p>
  </td>
  <td width="23" style="border:none;font-size:12.0pt;padding:0in 0in 0in 0in;"><p style="margin:12.0pt 0in .0001pt;text-align:justify;text-indent:.5in;">&nbsp;</p></td>
 </tr>
 <tr>
  <td width="40" valign="top" style="padding:0in .7pt 0in .7pt;width:30.0pt;">
  <p align="right" style="margin:0in 0in .0001pt;text-align:right;text-indent:0in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">5.1</font></p>
  </td>
  <td width="24" valign="top" style="padding:0in .7pt 0in .7pt;width:.25in;">
  <p style="font-size:1.0pt;margin:0in 0in .0001pt;text-indent:0in;">&nbsp;</p>
  </td>
  <td width="545" valign="top" style="padding:0in .7pt 0in .7pt;width:408.4pt;">
  <p style="margin:0in 0in .0001pt;text-indent:0in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">Opinion of Wilson Sonsini Goodrich &amp; Rosati,
  P.C., as to the legality of securities being registered.</font></p>
  </td>
  <td width="23" style="border:none;font-size:1.0pt;padding:0in 0in 0in 0in;"><p style="margin:12.0pt 0in .0001pt;text-align:justify;text-indent:.5in;">&nbsp;</p></td>
 </tr>
 <tr>
  <td width="40" valign="top" style="padding:0in .7pt 0in .7pt;width:30.0pt;">
  <p align="right" style="font-size:11.0pt;margin:0in 0in .0001pt;text-align:right;text-indent:0in;">&nbsp;</p>
  </td>
  <td width="24" valign="top" style="padding:0in .7pt 0in .7pt;width:.25in;">
  <p style="font-size:11.0pt;margin:0in 0in .0001pt;text-indent:0in;">&nbsp;</p>
  </td>
  <td width="545" valign="top" style="padding:0in .7pt 0in .7pt;width:408.4pt;">
  <p style="font-size:11.0pt;margin:0in 0in .0001pt;text-indent:0in;">&nbsp;</p>
  </td>
  <td width="23" style="border:none;font-size:12.0pt;padding:0in 0in 0in 0in;"><p style="margin:12.0pt 0in .0001pt;text-align:justify;text-indent:.5in;">&nbsp;</p></td>
 </tr>
 <tr>
  <td width="40" valign="top" style="padding:0in .7pt 0in .7pt;width:30.0pt;">
  <p align="right" style="margin:0in 0in .0001pt;text-align:right;text-indent:0in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">23.1</font></p>
  </td>
  <td width="24" valign="top" style="padding:0in .7pt 0in .7pt;width:.25in;">
  <p align="left" style="font-size:1.0pt;margin:0in 0in .0001pt;text-align:left;text-indent:0in;">&nbsp;</p>
  </td>
  <td width="545" valign="top" style="padding:0in .7pt 0in .7pt;width:408.4pt;">
  <p align="left" style="margin:0in 0in .0001pt;text-align:left;text-indent:0in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">Consent of Ernst &amp; Young LLP, Independent Auditors.</font></p>
  </td>
  <td width="23" style="border:none;font-size:1.0pt;padding:0in 0in 0in 0in;"><p style="margin:12.0pt 0in .0001pt;text-align:justify;text-indent:.5in;">&nbsp;</p></td>
 </tr>
 <tr>
  <td width="40" valign="top" style="padding:0in .7pt 0in .7pt;width:30.0pt;">
  <p align="right" style="font-size:12.0pt;margin:0in 0in .0001pt;text-align:right;text-indent:0in;">&nbsp;</p>
  </td>
  <td width="24" valign="top" style="padding:0in .7pt 0in .7pt;width:.25in;">
  <p align="left" style="font-size:12.0pt;margin:0in 0in .0001pt;text-align:left;text-indent:0in;">&nbsp;</p>
  </td>
  <td width="545" valign="top" style="padding:0in .7pt 0in .7pt;width:408.4pt;">
  <p align="left" style="font-size:12.0pt;margin:0in 0in .0001pt;text-align:left;text-indent:0in;">&nbsp;</p>
  </td>
  <td width="23" style="border:none;font-size:12.0pt;padding:0in 0in 0in 0in;"><p style="margin:12.0pt 0in .0001pt;text-align:justify;text-indent:.5in;">&nbsp;</p></td>
 </tr>
 <tr>
  <td width="40" valign="top" style="padding:0in .7pt 0in .7pt;width:30.0pt;">
  <p align="right" style="margin:0in 0in .0001pt;text-align:right;text-indent:0in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">23.2</font></p>
  </td>
  <td width="24" valign="top" style="padding:0in .7pt 0in .7pt;width:.25in;">
  <p align="left" style="font-size:1.0pt;margin:0in 0in .0001pt;text-align:left;text-indent:0in;">&nbsp;</p>
  </td>
  <td width="545" valign="top" style="padding:0in .7pt 0in .7pt;width:408.4pt;">
  <p align="left" style="margin:0in 0in .0001pt;text-align:left;text-indent:0in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">Consent of Counsel (contained in Exhibit 5.1).</font></p>
  </td>
  <td width="23" style="border:none;font-size:1.0pt;padding:0in 0in 0in 0in;"><p style="margin:12.0pt 0in .0001pt;text-align:justify;text-indent:.5in;">&nbsp;</p></td>
 </tr>
 <tr>
  <td width="40" valign="top" style="padding:0in .7pt 0in .7pt;width:30.0pt;">
  <p align="right" style="font-size:12.0pt;margin:0in 0in .0001pt;text-align:right;text-indent:0in;">&nbsp;</p>
  </td>
  <td width="24" valign="top" style="padding:0in .7pt 0in .7pt;width:.25in;">
  <p align="left" style="font-size:12.0pt;margin:0in 0in .0001pt;text-align:left;text-indent:0in;">&nbsp;</p>
  </td>
  <td width="545" valign="top" style="padding:0in .7pt 0in .7pt;width:408.4pt;">
  <p align="left" style="font-size:12.0pt;margin:0in 0in .0001pt;text-align:left;text-indent:0in;">&nbsp;</p>
  </td>
  <td width="23" style="border:none;font-size:12.0pt;padding:0in 0in 0in 0in;"><p style="margin:12.0pt 0in .0001pt;text-align:justify;text-indent:.5in;">&nbsp;</p></td>
 </tr>
 <tr>
  <td width="40" valign="top" style="padding:0in .7pt 0in .7pt;width:30.0pt;">
  <p align="right" style="margin:0in 0in .0001pt;text-align:right;text-indent:0in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">24.1</font></p>
  </td>
  <td width="24" valign="top" style="padding:0in .7pt 0in .7pt;width:.25in;">
  <p align="left" style="font-size:1.0pt;margin:0in 0in .0001pt;text-align:left;text-indent:0in;">&nbsp;</p>
  </td>
  <td width="545" valign="top" style="padding:0in .7pt 0in .7pt;width:408.4pt;">
  <p align="left" style="margin:0in 0in .0001pt;text-align:left;text-indent:0in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">Power of Attorney (see Page II-5).</font></p>
  </td>
  <td width="23" style="border:none;font-size:1.0pt;padding:0in 0in 0in 0in;"><p style="margin:12.0pt 0in .0001pt;text-align:justify;text-indent:.5in;">&nbsp;</p></td>
 </tr>
</table>

<p align="left" style="margin:12.0pt 0in .0001pt;text-align:left;text-indent:0in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">________</font></p>

<table border="0" cellspacing="0" cellpadding="0" width="100%" style="border-collapse:collapse;font-family:'Times New Roman';width:100.0%;">
 <tr>
  <td width="3%" valign="top" style="padding:0in .7pt 0in .7pt;width:3.8%;">
  <p align="left" style="margin:0in 0in .0001pt 10.0pt;text-align:left;text-indent:-10.0pt;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">*</font></p>
  </td>
  <td width="2%" valign="bottom" style="padding:0in .7pt 0in .7pt;width:2.66%;">
  <p align="left" style="font-size:1.0pt;margin:0in 0in .0001pt;text-align:left;text-indent:0in;">&nbsp;</p>
  </td>
  <td width="90%" valign="bottom" style="padding:0in .7pt 0in .7pt;width:90.9%;">
  <p align="left" style="margin:0in 0in .0001pt;text-align:left;text-indent:0in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">Incorporated by reference to the appendix
  filed with the Registrant&#146;s definitive Proxy Statement filed pursuant to
  Section 14(a) with the Securities and Exchange Commission on April 17, 2001.</font></p>
  </td>
  <td width="2%" valign="bottom" style="padding:0in .7pt 0in .7pt;width:2.66%;">
  <p align="left" style="font-size:1.0pt;margin:0in 0in .0001pt;text-align:left;text-indent:0in;">&nbsp;</p>
  </td>
 </tr>
 <tr>
  <td width="3%" valign="bottom" style="padding:0in .7pt 0in .7pt;width:3.8%;">
  <p align="center" style="font-size:12.0pt;margin:0in 0in .0001pt 10.0pt;text-align:center;text-indent:-10.0pt;">&nbsp;</p>
  </td>
  <td width="2%" valign="bottom" style="padding:0in .7pt 0in .7pt;width:2.66%;">
  <p align="left" style="font-size:12.0pt;margin:0in 0in .0001pt;text-align:left;text-indent:0in;">&nbsp;</p>
  </td>
  <td width="90%" valign="bottom" style="padding:0in .7pt 0in .7pt;width:90.9%;">
  <p align="left" style="font-size:12.0pt;margin:0in 0in .0001pt;text-align:left;text-indent:0in;">&nbsp;</p>
  </td>
  <td width="2%" valign="bottom" style="padding:0in .7pt 0in .7pt;width:2.66%;">
  <p align="left" style="font-size:12.0pt;margin:0in 0in .0001pt;text-align:left;text-indent:0in;">&nbsp;</p>
  </td>
 </tr>
 <tr>
  <td width="3%" valign="top" style="padding:0in .7pt 0in .7pt;width:3.8%;">
  <p align="left" style="margin:0in 0in .0001pt 10.0pt;text-align:left;text-indent:-10.0pt;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">**</font></p>
  </td>
  <td width="2%" valign="bottom" style="padding:0in .7pt 0in .7pt;width:2.66%;">
  <p align="left" style="font-size:1.0pt;margin:0in 0in .0001pt;text-align:left;text-indent:0in;">&nbsp;</p>
  </td>
  <td width="90%" valign="bottom" style="padding:0in .7pt 0in .7pt;width:90.9%;">
  <p align="left" style="margin:0in 0in .0001pt;text-align:left;text-indent:0in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">Incorporated by reference to the exhibit
  filed with the Registrant&#146;s registration statement on Form SB-2 (file no.
  333-476-LA) filed with the Securities and Exchange Commission on January 18,
  1996.</font></p>
  </td>
  <td width="2%" valign="bottom" style="padding:0in .7pt 0in .7pt;width:2.66%;">
  <p align="left" style="font-size:1.0pt;margin:0in 0in .0001pt;text-align:left;text-indent:0in;">&nbsp;</p>
  </td>
 </tr>
</table>

<p align="left" style="margin:12.0pt 0in .0001pt;text-align:left;text-indent:0in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>

<p align="center" style="margin:12.0pt 0in .0001pt;text-align:center;text-indent:0in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">II-6</font></p>


<div align="left" style="margin:12.0pt 0in .0001pt;text-align:left;text-indent:0in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">

<hr size="2" width="100%" noshade color="gray" align="left">

</font></div>

<font size="3" style="font-size:12.0pt;">
<!-- ZEQ.=1,SEQ=7,EFW="2076728",CP="SUPERGEN, INC.",DN="1",CHK=679827,FOLIO='',FILE="DISK012:[02PAL7.02PAL1547.EDGAR]S-8_1547.CHC",USER="DNICHOL",CD='Apr 19 13:31 2002' -->
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[{"type": "S-8", "sequence": "1", "filename": "a2076728zs-8.htm", "description": "S-8", "secsgml_size_bytes": 99534}]
{"company-data": {"conformed-name": "SUPERGEN INC", "cik": "0000919722", "assigned-sic": "2834", "irs-number": "911841574", "state-of-incorporation": "DE", "fiscal-year-end": "1231"}, "filing-values": {"form-type": "S-8", "act": "33", "file-number": "333-86644", "film-number": "02615910"}, "business-address": {"street1": "4140 DUBLIN BLVD", "street2": "SUITE 200", "city": "DUBLIN", "state": "CA", "zip": "94568", "phone": "9255600100"}, "mail-address": {"street1": "4140 DUBLIN BLVD", "street2": "STE 200", "city": "DUBLIN", "state": "CA", "zip": "94568"}}
As filed with the
Securities and Exchange Commission on April 19, 2002
Registration
No. 333-
SECURITIES
  AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM S-8
REGISTRATION
  STATEMENT
Under
The Securities Act of 1933
SUPERGEN,
  INC.
(Exact name of Registrant as specified in its
  charter)
Delaware
(State
  or other jurisdiction of
incorporation
  or organization)
91-1841574
(I.R.S.
  Employer Identification Number)
4140
  Dublin Boulevard, Suite 200
Dublin, California  94568
(Address
  of principal executive offices)
1996 Directors' Stock Option Plan
1998 Employee Stock Purchase Plan
(Full
  titles of the plans)
Joseph Rubinfeld, Ph.D.
Chief Executive Officer
SUPERGEN, INC.
4140 Dublin Boulevard, Suite 200
Dublin, California  94568
(925) 560-0100
(Name,
  address and telephone number of agent for service)
Copy
  to:
John
  V. Roos, Esq.
Wilson
  Sonsini Goodrich & Rosati, P.C.
650
  Page Mill Road
Palo
  Alto, California 94304
CALCULATION OF REGISTRATION FEE
Title of Securities to be
  Registered
Amount
  to be
Registered (1)
Proposed
  Maximum
Offering Price
Per Share (2)
Proposed
  Maximum
Aggregate
Offering Price (2)
Amount
  of
Registration Fee
Common
  Stock, $.001 par value
500,000
$5.65
$2,825,000
$259.90
__________
(1)
Pursuant to Rule 429
of the Securities Act of 1933, as amended (the "Securities Act"), the
prospectus delivered to participants under the Registrant's 1996 Directors'
Stock Option Plan, as amended (the "Directors' Plan"), also relates to 250,000
shares previously registered under Form S-8 Registration No. 333-07295.  Pursuant to Rule 429 of the Securities Act,
the prospectus delivered to participants under the Registrant's 1998 Employee
Stock Purchase Plan, as amended (the "Purchase Plan"), also relates to 100,000
shares previously registered under Form S-8 Registration No. 333-58303.  Includes 300,000 shares to be registered
under the Directors' Plan and 200,000 shares to be registered under the
Purchase Plan.
(2)
The Proposed Maximum
Offering Price Per Share was estimated pursuant to Rule 457(c) under the
Securities Act whereby the per share price was determined by reference to the
average between the high and low prices reported in the Nasdaq National Market
on April 12, 2002, which average was $5.65.
PART II
INFORMATION
REQUIRED IN THE REGISTRATION STATEMENT
Item 3
.
Incorporation of Documents by Reference
SuperGen, Inc. (the
"Company") hereby incorporates by reference in this registration statement the
following documents:
(a) The Company's Annual Report on Form 10-K
for the fiscal year ended December 31, 2001, pursuant to Section 13 of the
Securities Exchange Act of 1934, as amended (the "Exchange Act").
(b) All other reports filed pursuant to Section
13(a) or 15(d) of the Exchange Act since the end of the fiscal year covered by
the registrant document referred to in (a) above.
(c) The description of the Company's Common Stock
to be offered hereby is contained in the Company's Registration Statement on
Form 8-A filed with the Commission on January 18, 1996 pursuant to Section
12(g) of the Exchange Act, including any amendment or report filed for the
purpose of updating such description.
All documents
subsequently filed by the Company pursuant to Sections 13(a), 13(c), 14
and 15(d) of the Exchange Act, prior to the filing of a post-effective
amendment to this registration statement which indicates that all securities
offered hereby have been sold or which deregisters all securities remaining
unsold, shall be deemed to be incorporated by reference in this registration
statement and to be a part hereof from the date of filing of such documents.
Item 4
.
Description
of Securities
Not applicable.
Item 5
.
Interests
of Named Experts and Counsel
Not applicable.
Item 6
.
Indemnification
of Directors and Officers
The Company has adopted
provisions in its current Certificate of Incorporation which (i) eliminate the
personal liability of its directors to the Company for monetary damages to the
fullest extent permissible under Delaware law; and (ii) authorize the company
to indemnify its directors and officers to the fullest extent permitted by
law.  Such limitation of liability does
not affect the availability of equitable remedies, such as injunctive relief or
rescission.  The Company's Certificate
of Incorporation also includes a provision eliminating, to the fullest extent
permitted by Delaware law, the personal liability of its directors for monetary
damages for breach of fiduciary duty as a director.  In addition, the Bylaws of the Company provide that it will be
required to indemnify its officers and directors to the maximum extent and in
the manner permitted by the Delaware General Corporation Law.
The Company has entered
into separate indemnification agreements with each of its officers, directors
and key employees that contain provisions which are in some respects broader
than the specific indemnification provisions contained in the Delaware General
Corporation Law.  The indemnification
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agreements may
require the Company, among other things, to indemnify such officers and
directors against certain liabilities that may arise by reason of their status
or service as directors or officers (other than liabilities arising from
willful misconduct of a culpable nature), to advance their expenses incurred as
a result of any proceeding against them, as to which they could be indemnified,
and to obtain director's and officer's insurance, if available on reasonable
terms.  Insofar as indemnification for
liabilities arising under the Securities Act of 1933, as amended (the
"Securities Act"), may be permitted to directors, officers and controlling
persons of the Registrant pursuant to the foregoing provisions, or otherwise,
the Registrant has been advised that in the opinion of the Commission such
indemnification is against public policy as expressed in the Securities Act and
is, therefore, unenforceable.
At present, the Company
is not aware of any pending litigation involving a director, officer, employee
or agent of the Company where indemnification will be required or
permitted.  The Company is not aware of
any threatened litigation or proceeding which may result in a claim for such
indemnification.
Item 7
.
Exemption
From Registration Claimed
Not applicable.
Item 8
.
Exhibits
4.1
*
1996 Directors Stock Option Plan (as amended effective February 7,
  2001).
4.2
**
Form of Stock Option Agreement for use under the 1996 Directors
  Stock Option Plan.
4.3
*
1998 Employee Stock Purchase Plan (as amended effective February 7,
  2001).
5.1
Opinion of Wilson Sonsini Goodrich & Rosati,
  P.C., as to the legality of securities being registered.
23.1
Consent of Ernst & Young LLP, Independent Auditors.
23.2
Consent of Counsel (contained in Exhibit 5.1).
24.1
Power of Attorney (see Page II-5)
_________
*
Incorporated by reference to the appendix
filed with the Registrant's definitive Proxy Statement filed pursuant to
Section 14(a) with the Securities and Exchange Commission on April 17, 2001.
**
Incorporated by reference to the exhibit
filed with the Registrant's registration statement on Form SB-2 (file no.
333-476-LA) filed with the Securities and Exchange Commission on January 18,
1996.
Item 9
.
Undertakings
(a)
Rule 415 Offering
. The undersigned
registrant hereby undertakes:
(1) To file, during any period in which offers or
sales are being made, a post-effective amendment to this registration statement
to include any material information with respect to the
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plan of distribution not previously disclosed
in the registration statement or any material change to such information in the
registration statement.
(2) That, for the purpose of determining any
liability under the Securities Act, each such post-effective amendment shall be
deemed to be a new registration statement relating to the securities offered
therein, and the offering of such securities at that time shall be deemed to be
the initial bona fide offering thereof.
(3) To remove from registration by means of a
post-effective amendment any of the securities being registered which remain unsold
at the termination of the offering.
(b)
Filings incorporating subsequent Exchange
Act documents by reference
.
The undersigned
registrant hereby undertakes that, for purposes of determining any liability
under the Securities Act, each filing of the registrant's annual report
pursuant to section 13(a) or section 15(d) of the Exchange Act (and, where
applicable, each filing of an employee benefit plan's annual report pursuant to
section 15(d) of the Exchange Act) that is incorporated by reference in the registration
statement shall be deemed to be a new registration statement relating to the
securities offered therein, and the offering of such securities at that time
shall be deemed to be the initial bona fide offering thereof.
(c)
Request for acceleration of effective date
or filing of registration statement on Form S-8
.
Insofar as
indemnification for liabilities arising under the Securities Act may be
permitted to directors, officers and controlling persons of the registrant
pursuant to the foregoing provisions, or otherwise, the registrant has been
advised that in the opinion of the Securities and Exchange Commission such
indemnification is against public policy as expressed in the Securities Act and
is, therefore, unenforceable.  In the
event that a claim for indemnification against such liabilities (other than the
payment by the registrant of expenses incurred or paid by a director, officer
or controlling person of the registrant in the successful defense of any
action, suit or proceeding) is asserted by such director, officer or
controlling person in connection with the securities being registered, the
registrant will, unless in the opinion of its counsel the matter has been
settled by controlling precedent, submit to a court of appropriate jurisdiction
the question whether such indemnification by it is against public policy as
expressed in the Securities Act and will be governed by the final adjudication
of such issue.
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SIGNATURES
Pursuant to the
requirements of the Securities Act of 1933, the registrant certifies that it
has reasonable grounds to believe that it meets all of the requirements for
filing on Form S-8 and has duly caused this registration statement to be
signed on its behalf by the undersigned, thereunto duly authorized, in the City
of Dublin, State of California, on April 19, 2002.
SUPERGEN, INC.
By:
/s/ JOSEPH RUBINFELD
Joseph Rubinfeld, Ph.D.
Chief Executive Officer, President and Director
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POWER OF ATTORNEY
KNOW ALL PERSONS BY THESE
PRESENTS, that each person whose signature appears below constitutes and
appoints Joseph Rubinfeld, his attorney-in-fact, for him in any and all
capacities, to sign any amendments to this registration statement on
Form S-8, and to file the same, with exhibits thereto and other documents
in connection therewith, with the Securities and Exchange Commission, hereby
ratifying and confirming all that said attorney-in-fact, or his substitute or
substitutes, may do or cause to be done by virtue hereof.
Pursuant to the
requirements of the Securities Act of 1933, this registration statement has
been signed below by the following persons in the capacities and on the dates
indicated.
Signature
Title
Date
/s/ JOSEPH RUBINFELD
(Joseph Rubinfeld)
Chief Executive Officer, President and Director
(Principal Executive Officer)
April 19, 2002
/s/
  EDWARD L. JACOBS
(Edward L. Jacobs)
Chief Business Officer/Chief Financial Officer
(Principal Financial and Accounting
  Officer)
April 19, 2002
/s/
  DENIS BURGER
(Denis Burger)
Director
April 19, 2002
/s/
  THOMAS V. GIRARDI
(Thomas V. Girardi)
Director
April 19, 2002
/s/
  WALTER J. LACK
(Walter J. Lack)
Director
April 19, 2002
/s/
  JAMES S. J. MANUSO
(James S. J. Manuso)
Director
April 19, 2002
/s/
  DANIEL ZURR
(Daniel Zurr)
Director
April 19, 2002
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SUPERGEN, INC.
REGISTRATION STATEMENT ON FORM S-8
EXHIBIT INDEX
Exhibit
Number
Description
4.1
*
1996 Directors Stock Option Plan (as amended effective February 7,
  2001).
4.2
**
Form of Stock Option Agreement for use under the 1996 Directors
  Stock Option Plan.
4.3
*
1998 Employee Stock Purchase Plan (as amended effective February 7,
  2001).
5.1
Opinion of Wilson Sonsini Goodrich & Rosati,
  P.C., as to the legality of securities being registered.
23.1
Consent of Ernst & Young LLP, Independent Auditors.
23.2
Consent of Counsel (contained in Exhibit 5.1).
24.1
Power of Attorney (see Page II-5).
________
*
Incorporated by reference to the appendix
  filed with the Registrant's definitive Proxy Statement filed pursuant to
  Section 14(a) with the Securities and Exchange Commission on April 17, 2001.
**
Incorporated by reference to the exhibit
  filed with the Registrant's registration statement on Form SB-2 (file no.
  333-476-LA) filed with the Securities and Exchange Commission on January 18,
  1996.
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