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<p align="center" style="letter-spacing:.25pt;margin:0in 0in .0001pt;text-align:center;"><b><font size="2" face="Times New Roman" style="font-size:10.0pt;font-weight:bold;">As filed with the Securities and
Exchange Commission on March 7, 2006</font></b></p>

<p align="right" style="letter-spacing:.25pt;margin:0in 0in .0001pt;text-align:right;"><b><font size="2" face="Times New Roman" style="font-size:10.0pt;font-weight:bold;letter-spacing:0pt;">File No. 333-&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</font></b></p>

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<p align="center" style="border:none;letter-spacing:.25pt;margin:0in 0in .0001pt;padding:0in;text-align:center;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>

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<p align="center" style="letter-spacing:.25pt;margin:0in 0in .0001pt;text-align:center;"><b><font size="5" face="Times New Roman" style="font-size:18.0pt;font-weight:bold;">UNITED STATES</font></b></p>

<p align="center" style="letter-spacing:.25pt;margin:0in 0in .0001pt;text-align:center;"><b><font size="5" face="Times New Roman" style="font-size:18.0pt;font-weight:bold;">SECURITIES AND EXCHANGE
COMMISSION</font></b></p>

<p align="center" style="letter-spacing:.25pt;margin:0in 0in .0001pt;text-align:center;"><b><font size="2" face="Times New Roman" style="font-size:10.0pt;font-weight:bold;">WASHINGTON, DC 20549</font></b></p>

<div align="center" style="letter-spacing:.25pt;margin:0in 0in .0001pt;text-align:center;"><hr size="1" width="25%" noshade color="black" align="center"></div>

<p align="center" style="letter-spacing:.25pt;margin:0in 0in .0001pt;text-align:center;"><b><font size="5" face="Times New Roman" style="font-size:18.0pt;font-weight:bold;">FORM S-8</font></b></p>

<p align="center" style="letter-spacing:.25pt;margin:0in 0in .0001pt;text-align:center;"><b><font size="3" face="Times New Roman" style="font-size:12.0pt;font-weight:bold;">REGISTRATION
STATEMENT<br>
UNDER<br>
THE SECURITIES ACT OF 1933</font></b></p>

<div align="center" style="letter-spacing:.25pt;margin:0in 0in .0001pt;text-align:center;"><hr size="1" width="25%" noshade color="black" align="center"></div>

<p align="center" style="letter-spacing:.25pt;margin:0in 0in .0001pt;text-align:center;"><b><font size="5" face="Times New Roman" style="font-size:18.0pt;font-weight:bold;">CUBIST PHARMACEUTICALS, INC.</font></b></p>

<p align="center" style="letter-spacing:.25pt;margin:0in 0in .0001pt;text-align:center;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">(Exact Name of Registrant
as Specified in Its Charter)</font></p>

<p align="center" style="letter-spacing:.25pt;margin:0in 0in .0001pt;text-align:center;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>

<table border="0" cellspacing="0" cellpadding="0" width="100%" style="border-collapse:collapse;width:100.0%;">
 <tr>
  <td width="49%" valign="top" style="padding:0in 0in 0in 0in;width:49.0%;">
  <p align="center" style="letter-spacing:.25pt;margin:0in 0in .0001pt;text-align:center;"><b><font size="2" face="Times New Roman" style="font-size:10.0pt;font-weight:bold;letter-spacing:0pt;">DELAWARE</font></b></p>
  </td>
  <td width="2%" valign="bottom" style="padding:0in 0in 0in 0in;width:2.0%;">
  <p align="left" style="letter-spacing:.25pt;margin:0in 0in .0001pt;text-align:left;"><b><font size="2" face="Times New Roman" style="font-size:1.0pt;font-weight:bold;letter-spacing:0pt;">&nbsp;</font></b></p>
  </td>
  <td width="49%" valign="top" style="padding:0in 0in 0in 0in;width:49.0%;">
  <p align="center" style="letter-spacing:.25pt;margin:0in 0in .0001pt;text-align:center;"><b><font size="2" face="Times New Roman" style="font-size:10.0pt;font-weight:bold;letter-spacing:0pt;">22-3192085</font></b></p>
  </td>
 </tr>
 <tr>
  <td width="49%" valign="top" style="padding:0in 0in 0in 0in;width:49.0%;">
  <p align="center" style="letter-spacing:.25pt;margin:0in 0in .0001pt;text-align:center;"><font size="2" face="Times New Roman" style="font-size:10.0pt;letter-spacing:0pt;">(State
  or Other Jurisdiction of Incorporation or Organization)</font></p>
  </td>
  <td width="2%" valign="bottom" style="padding:0in 0in 0in 0in;width:2.0%;">
  <p align="left" style="letter-spacing:.25pt;margin:0in 0in .0001pt;text-align:left;"><i><font size="2" face="Times New Roman" style="font-size:1.0pt;font-style:italic;letter-spacing:0pt;">&nbsp;</font></i></p>
  </td>
  <td width="49%" valign="top" style="padding:0in 0in 0in 0in;width:49.0%;">
  <p align="center" style="letter-spacing:.25pt;margin:0in 0in .0001pt;text-align:center;"><font size="2" face="Times New Roman" style="font-size:10.0pt;letter-spacing:0pt;">(I.R.S.
  Employer Identification No.)</font></p>
  </td>
 </tr>
</table>

<p align="center" style="letter-spacing:.25pt;margin:0in 0in .0001pt;text-align:center;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>

<p align="center" style="letter-spacing:.25pt;margin:0in 0in .0001pt;text-align:center;"><b><font size="2" face="Times New Roman" style="font-size:10.0pt;font-weight:bold;letter-spacing:0pt;">65 Hayden
Avenue, Lexington, MA 02421</font></b></p>

<p align="center" style="letter-spacing:.25pt;margin:0in 0in .0001pt;text-align:center;"><font size="2" face="Times New Roman" style="font-size:10.0pt;letter-spacing:0pt;">(Address
of Principal Executive Offices) (Zip Code)</font></p>

<p align="center" style="letter-spacing:.25pt;margin:0in 0in .0001pt;text-align:center;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>

<p align="center" style="letter-spacing:.25pt;margin:0in 0in .0001pt;text-align:center;"><b><font size="2" face="Times New Roman" style="font-size:10.0pt;font-weight:bold;letter-spacing:0pt;">CUBIST
PHARMACEUTICALS, INC.</font></b></p>

<p align="center" style="letter-spacing:.25pt;margin:0in 0in .0001pt;text-align:center;"><b><font size="2" face="Times New Roman" style="font-size:10.0pt;font-weight:bold;letter-spacing:0pt;">AMENDED AND
RESTATED 2000 EQUITY INCENTIVE PLAN</font></b></p>

<p align="center" style="letter-spacing:.25pt;margin:0in 0in .0001pt;text-align:center;"><font size="2" face="Times New Roman" style="font-size:10.0pt;letter-spacing:0pt;">(Full
Title of the Plan)</font></p>

<div align="center" style="letter-spacing:.25pt;margin:0in 0in .0001pt;text-align:center;"><hr size="1" width="25%" noshade color="black" align="center"></div>

<p align="center" style="letter-spacing:.25pt;margin:0in 0in .0001pt;text-align:center;"><b><font size="2" face="Times New Roman" style="font-size:10.0pt;font-weight:bold;letter-spacing:0pt;">Michael W.
Bonney</font></b></p>

<p align="center" style="letter-spacing:.25pt;margin:0in 0in .0001pt;text-align:center;"><b><font size="2" face="Times New Roman" style="font-size:10.0pt;font-weight:bold;letter-spacing:0pt;">President and
Chief Executive Officer</font></b></p>

<p align="center" style="letter-spacing:.25pt;margin:0in 0in .0001pt;text-align:center;"><b><font size="2" face="Times New Roman" style="font-size:10.0pt;font-weight:bold;letter-spacing:0pt;">CUBIST PHARMACEUTICALS, INC.</font></b></p>

<p align="center" style="letter-spacing:.25pt;margin:0in 0in .0001pt;text-align:center;"><b><font size="2" face="Times New Roman" style="font-size:10.0pt;font-weight:bold;letter-spacing:0pt;">65 Hayden
Avenue</font></b></p>

<p align="center" style="letter-spacing:.25pt;margin:0in 0in .0001pt;text-align:center;"><b><font size="2" face="Times New Roman" style="font-size:10.0pt;font-weight:bold;letter-spacing:0pt;">Lexington,
Massachusetts 02421</font></b></p>

<p align="center" style="letter-spacing:.25pt;margin:0in 0in .0001pt;text-align:center;"><font size="2" face="Times New Roman" style="font-size:10.0pt;letter-spacing:0pt;">(Name
and Address of Agent For Service)</font></p>

<p align="center" style="letter-spacing:.25pt;margin:0in 0in .0001pt;text-align:center;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>

<p align="center" style="letter-spacing:.25pt;margin:0in 0in .0001pt;text-align:center;"><b><font size="2" face="Times New Roman" style="font-size:10.0pt;font-weight:bold;letter-spacing:0pt;">(781) 860-8660</font></b></p>

<p align="center" style="letter-spacing:.25pt;margin:0in 0in .0001pt;text-align:center;"><font size="2" face="Times New Roman" style="font-size:10.0pt;letter-spacing:0pt;">Telephone
Number, Including Area Code, of Agent for Service</font></p>

<div align="center" style="letter-spacing:.25pt;margin:0in 0in .0001pt;text-align:center;"><hr size="1" width="25%" noshade color="black" align="center"></div>

<p align="center" style="letter-spacing:.25pt;margin:0in 0in .0001pt;text-align:center;"><i><font size="2" face="Times New Roman" style="font-size:10.0pt;font-style:italic;letter-spacing:0pt;">Copies to:</font></i></p>

<p align="center" style="font-size:10.0pt;letter-spacing:.25pt;margin:0in 0in .0001pt;text-align:center;"><b><font size="2" face="Times New Roman" style="font-size:10.0pt;font-weight:bold;letter-spacing:0pt;">Julio E. Vega,
Esq</font></b><font style="letter-spacing:0pt;">.</font></p>

<p align="center" style="letter-spacing:.25pt;margin:0in 0in .0001pt;text-align:center;"><b><font size="2" face="Times New Roman" style="font-size:10.0pt;font-weight:bold;letter-spacing:0pt;">Matthew J.
Cushing, Esq.</font></b></p>

<p align="center" style="letter-spacing:.25pt;margin:0in 0in .0001pt;text-align:center;"><b><font size="2" face="Times New Roman" style="font-size:10.0pt;font-weight:bold;letter-spacing:0pt;">BINGHAM MCCUTCHEN LLP</font></b></p>

<p align="center" style="letter-spacing:.25pt;margin:0in 0in .0001pt;text-align:center;"><b><font size="2" face="Times New Roman" style="font-size:10.0pt;font-weight:bold;letter-spacing:0pt;">150 Federal
Street</font></b></p>

<p align="center" style="letter-spacing:.25pt;margin:0in 0in .0001pt;text-align:center;"><b><font size="2" face="Times New Roman" style="font-size:10.0pt;font-weight:bold;letter-spacing:0pt;">Boston, MA
02110-1726</font></b></p>

<p align="center" style="letter-spacing:.25pt;margin:0in 0in .0001pt;text-align:center;"><b><font size="2" face="Times New Roman" style="font-size:10.0pt;font-weight:bold;letter-spacing:0pt;">(617) 951-8000</font></b></p>

<p align="center" style="letter-spacing:.25pt;margin:0in 0in .0001pt;text-align:center;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>

<p align="center" style="letter-spacing:.25pt;margin:0in 0in .0001pt;text-align:center;"><b><font size="2" face="Times New Roman" style="font-size:10.0pt;font-weight:bold;letter-spacing:0pt;">CALCULATION OF
REGISTRATION FEE</font></b></p>

<table border="0" cellspacing="0" cellpadding="0" width="100%" style="border-collapse:collapse;width:100.0%;">
 <tr>
  <td width="30%" valign="bottom" style="border:none;border-bottom:solid windowtext 1.0pt;padding:0in 0in 0in 0in;width:30.5%;">
  <p align="left" style="letter-spacing:.25pt;margin:0in 0in .0001pt;text-align:left;"><b><font size="1" face="Times New Roman" style="font-size:8.0pt;font-weight:bold;">Title
  Of<br>
  Securities To Be Registered</font></b></p>
  </td>
  <td width="2%" valign="bottom" style="padding:0in 0in 0in 0in;width:2.0%;">
  <p align="left" style="letter-spacing:.25pt;margin:0in 0in .0001pt;text-align:left;"><b><font size="1" face="Times New Roman" style="font-size:1.0pt;font-weight:bold;">&nbsp;</font></b></p>
  </td>
  <td width="15%" valign="bottom" style="border:none;border-bottom:solid windowtext 1.0pt;padding:0in 0in 0in 0in;width:15.0%;">
  <p align="center" style="letter-spacing:.25pt;margin:0in 0in .0001pt;text-align:center;"><b><font size="1" face="Times New Roman" style="font-size:8.0pt;font-weight:bold;">Amount<br>
  To Be<br>
  Registered</font></b></p>
  </td>
  <td width="2%" valign="bottom" style="padding:0in 0in 0in 0in;width:2.0%;">
  <p align="left" style="letter-spacing:.25pt;margin:0in 0in .0001pt;text-align:left;"><b><font size="1" face="Times New Roman" style="font-size:1.0pt;font-weight:bold;">&nbsp;</font></b></p>
  </td>
  <td width="15%" colspan="2" valign="bottom" style="border:none;border-bottom:solid windowtext 1.0pt;padding:0in 0in 0in 0in;width:15.0%;">
  <p align="center" style="letter-spacing:.25pt;margin:0in 0in .0001pt;text-align:center;"><b><font size="1" face="Times New Roman" style="font-size:8.0pt;font-weight:bold;">Proposed Maximum<br>
  Offering Price<br>
  Per Share</font></b></p>
  </td>
  <td width="2%" valign="bottom" style="padding:0in 0in 0in 0in;width:2.5%;">
  <p align="left" style="letter-spacing:.25pt;margin:0in 0in .0001pt;text-align:left;"><b><font size="1" face="Times New Roman" style="font-size:1.0pt;font-weight:bold;">&nbsp;</font></b></p>
  </td>
  <td width="15%" colspan="2" valign="bottom" style="border:none;border-bottom:solid windowtext 1.0pt;padding:0in 0in 0in 0in;width:15.0%;">
  <p align="center" style="letter-spacing:.25pt;margin:0in 0in .0001pt;text-align:center;"><b><font size="1" face="Times New Roman" style="font-size:8.0pt;font-weight:bold;">Proposed Maximum<br>
  Aggregate<br>
  Offering Price </font></b><b><font size="1" style="font-size:8.0pt;font-weight:bold;">(1)</font></b></p>
  </td>
  <td width="2%" valign="bottom" style="padding:0in 0in 0in 0in;width:2.0%;">
  <p align="left" style="letter-spacing:.25pt;margin:0in 0in .0001pt;text-align:left;"><b><font size="1" face="Times New Roman" style="font-size:1.0pt;font-weight:bold;">&nbsp;</font></b></p>
  </td>
  <td width="15%" colspan="2" valign="bottom" style="border:none;border-bottom:solid windowtext 1.0pt;padding:0in 0in 0in 0in;width:15.0%;">
  <p align="center" style="letter-spacing:.25pt;margin:0in 0in .0001pt;text-align:center;"><b><font size="1" face="Times New Roman" style="font-size:8.0pt;font-weight:bold;">Amount Of<br>
  Registration<br>
  Fee</font></b></p>
  </td>
  <td width="1%" valign="bottom" style="padding:0in 0in 0in 0in;width:1.0%;">
  <p align="left" style="letter-spacing:.25pt;margin:0in 0in .0001pt;text-align:left;"><b><font size="1" face="Times New Roman" style="font-size:1.0pt;font-weight:bold;">&nbsp;</font></b></p>
  </td>
 </tr>
 <tr>
  <td width="30%" valign="top" style="border:none;padding:0in 0in 0in 0in;width:30.5%;">
  <p align="left" style="letter-spacing:.25pt;margin:0in 0in .0001pt;text-align:left;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">Common Stock, $0.001
  par value</font></p>
  </td>
  <td width="2%" valign="bottom" style="padding:0in 0in 0in 0in;width:2.0%;">
  <p align="left" style="letter-spacing:.25pt;margin:0in 0in .0001pt;text-align:left;"><font size="2" face="Times New Roman" style="font-size:1.0pt;">&nbsp;</font></p>
  </td>
  <td width="15%" valign="bottom" style="border:none;border-bottom:solid windowtext 1.0pt;padding:0in 0in 0in 0in;width:15.0%;">
  <p align="right" style="letter-spacing:.25pt;margin:0in 0in .0001pt;text-align:right;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">3,046,436</font></p>
  </td>
  <td width="2%" valign="bottom" style="padding:0in 0in 0in 0in;width:2.0%;">
  <p align="left" style="letter-spacing:.25pt;margin:0in 0in .0001pt;text-align:left;"><font size="2" face="Times New Roman" style="font-size:1.0pt;">&nbsp;</font></p>
  </td>
  <td width="1%" valign="bottom" style="border:none;border-bottom:solid windowtext 1.0pt;padding:0in 0in 0in 0in;width:1.3%;">
  <p align="left" style="letter-spacing:.25pt;margin:0in 0in .0001pt;text-align:left;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">$</font></p>
  </td>
  <td width="13%" valign="bottom" style="border-bottom:solid windowtext 1.0pt;border-left:none;border-right:none;border-top:solid windowtext 1.0pt;padding:0in 0in 0in 0in;width:13.7%;">
  <p align="right" style="letter-spacing:.25pt;margin:0in 0in .0001pt;text-align:right;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">22.60</font></p>
  </td>
  <td width="2%" valign="bottom" style="padding:0in 0in 0.375pt 0in;width:2.5%;">
  <p align="left" style="letter-spacing:.25pt;margin:0in 0in .0001pt;text-align:left;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">(1)</font></p>
  </td>
  <td width="1%" valign="bottom" style="border:none;border-bottom:solid windowtext 1.0pt;padding:0in 0in 0in 0in;width:1.3%;">
  <p align="left" style="letter-spacing:.25pt;margin:0in 0in .0001pt;text-align:left;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">$</font></p>
  </td>
  <td width="13%" valign="bottom" style="border-bottom:solid windowtext 1.0pt;border-left:none;border-right:none;border-top:solid windowtext 1.0pt;padding:0in 0in 0in 0in;width:13.7%;">
  <p align="right" style="letter-spacing:.25pt;margin:0in 0in .0001pt;text-align:right;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">68,849,453</font></p>
  </td>
  <td width="2%" valign="bottom" style="padding:0in 0in 0in 0in;width:2.0%;">
  <p align="left" style="letter-spacing:.25pt;margin:0in 0in .0001pt;text-align:left;"><font size="2" face="Times New Roman" style="font-size:1.0pt;">&nbsp;</font></p>
  </td>
  <td width="1%" valign="bottom" style="border:none;border-bottom:solid windowtext 1.0pt;padding:0in 0in 0in 0in;width:1.3%;">
  <p align="left" style="letter-spacing:.25pt;margin:0in 0in .0001pt;text-align:left;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">$</font></p>
  </td>
  <td width="13%" valign="bottom" style="border-bottom:solid windowtext 1.0pt;border-left:none;border-right:none;border-top:solid windowtext 1.0pt;padding:0in 0in 0in 0in;width:13.7%;">
  <p align="right" style="letter-spacing:.25pt;margin:0in 0in .0001pt;text-align:right;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">7,366.89</font></p>
  </td>
  <td width="1%" valign="bottom" style="padding:0in 0in 0in 0in;width:1.0%;">
  <p align="left" style="letter-spacing:.25pt;margin:0in 0in .0001pt;text-align:left;"><font size="2" face="Times New Roman" style="font-size:1.0pt;">&nbsp;</font></p>
  </td>
 </tr>
 <tr height="0">
  <td width="228" style="border:none;"></td>
  <td width="15" style="border:none;"></td>
  <td width="112" style="border:none;"></td>
  <td width="15" style="border:none;"></td>
  <td width="10" style="border:none;"></td>
  <td width="102" style="border:none;"></td>
  <td width="19" style="border:none;"></td>
  <td width="10" style="border:none;"></td>
  <td width="102" style="border:none;"></td>
  <td width="15" style="border:none;"></td>
  <td width="10" style="border:none;"></td>
  <td width="102" style="border:none;"></td>
  <td width="7" style="border:none;"></td>
 </tr>
</table>

<p style="letter-spacing:.25pt;margin:0in 0in .0001pt;text-align:justify;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>

<div align="left" style="letter-spacing:.25pt;margin:0in 0in .0001pt;text-align:left;"><hr size="1" width="25%" noshade color="black" align="left"></div>

<p style="letter-spacing:.25pt;margin:0in 0in .0001pt;"><font size="2" face="Times New Roman" style="font-size:10.0pt;letter-spacing:0pt;">(1)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; The proposed maximum offering price
has been estimated pursuant to Rule 457(h) solely for the purpose of
calculating the registration fee.&#160; It is
not known how many of these shares will be purchased or at what price.&#160; The estimate of the proposed maximum
aggregate offering price has been calculated based on the offering of all </font><font size="2" style="font-size:10.0pt;">3,046,436 </font><font size="2" style="font-size:10.0pt;letter-spacing:0pt;">shares registered hereunder
pursuant to the grant of stock options under the</font><font size="2" style="font-size:10.0pt;"> </font><font size="2" style="font-size:10.0pt;letter-spacing:0pt;">Amended and Restated 2000 Equity Incentive Plan
exercisable for all of such shares, at an exercise price of $22.60 per share,
which is the average of the high and low prices of Cubist&#146;s common stock as
listed on the National Association of Securities Dealers Automated Quotation
National Market System on February 28, 2006.</font></p>

<p align="left" style="letter-spacing:.25pt;margin:0in 0in .0001pt .5in;text-align:left;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>

<p align="left" style="font-size:10.0pt;letter-spacing:.25pt;margin:0in 0in .0001pt;text-align:left;text-indent:.5in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;letter-spacing:0pt;">Pursuant to Rule 429 promulgated under the Securities Act of 1933, as
amended, the prospectus relating to this Registration Statement is a combined
prospectus that relates also to the Registration Statement on Form S-8 (File
No. 333-124210) previously filed by the registrant on April 21, 2005, which
registers </font>2,900,000 shares
of common stock,<font style="letter-spacing:0pt;"> the Registration
Statement on Form S-8 (File No. 333-118065) previously filed by the registrant
on August 10, 2004, which registers </font>3,866,564 shares of common stock, <font style="letter-spacing:0pt;">the Registration Statement on Form S-8 (File No. 333-106388) previously
filed by the registrant on June 23, 2003, which registers 60,000 shares of
common stock, Registration Statement on Form S-8 (File No. 333-99739)
previously filed by the registrant on September 18, 2002, which registers
1,927,067 shares of common stock, Registration Statement on Form S-8 (File No.
333-60168) previously filed by the registrant on May 3, 2001, which registers
1,500,000 shares of common stock, Registration Statement on Form&nbsp;S-8</font></p>

<p align="left" style="letter-spacing:.25pt;margin:0in 0in .0001pt;text-align:left;"><font size="2" face="Times New Roman" style="font-size:10.0pt;letter-spacing:0pt;">(File&nbsp;No.&nbsp;333-60152)
previously filed by the registrant on May 3, 2001, which registers 1,080,359
shares of common stock, Registration Statement on Form S-8 (File No. 333-49522)
previously filed by the registrant on November 8, 2000, which registers
1,000,000 shares of common stock, Registration Statement on Form S-8 (File No.
333-32178) previously filed by the registrant on March 10, 2000, which
registers 844,573 shares of common stock, the Registration Statement on Form
S-8 (File No. 333-65385) previously filed by the registrant on October 6, 1998,
which registers 655,427 shares of common stock, and the Registration Statement
on Form S-8 (File No. 33-25707) previously filed by the registrant on April 23,
1997, which registers 1,500,000 shares of common stock. An aggregate filing fee
for all such prior registration statements in the amount of $53,286.12 was
previously paid with respect to such shares.</font></p>

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<p align="center" style="border:none;letter-spacing:.25pt;margin:0in 0in .0001pt;padding:0in;text-align:center;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>

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<p align="center" style="letter-spacing:.25pt;margin:0in 0in .0001pt;text-align:center;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>

<p align="center" style="letter-spacing:.25pt;margin:0in 0in .0001pt;text-align:center;"><font size="2" face="Times New Roman" style="font-size:10.0pt;letter-spacing:0pt;">EXPLANATORY
NOTE</font></p>

<p align="center" style="letter-spacing:.25pt;margin:0in 0in .0001pt;text-align:center;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>

<p style="font-size:10.0pt;margin:0in 0in .0001pt;text-indent:.5in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">On April 23, 1997, we filed a Registration Statement on Form S-8 (File No. 333-25707) (referred to in this document as, the &#147;First Registration Statement&#148;) to register under the Securities Act of 1933, as amended, or, the Securities Act, 1,500,000 shares of common stock, par value $0.001 per share, issuable by us under the Amended and Restated 1993 Stock Option Plan, or, the 1993 Plan. On October 6, 1998, we filed a Registration Statement on Form S-8 (File No. 333-65385) (referred to in this document as the &#147;Second Registration Statement&#148;) to register under the Securities Act an additional 655,427 shares of our common stock issuable by us under the 1993 Plan. On March 10, 2000, we filed a Registration Statement on Form S-8 (File No. 333-32178) (referred to in this document as the &#147;Third Registration Statement&#148;) to register under the Securities Act an additional 844,573 shares of our common stock issuable by us under the 1993 Plan. On November 8, 2000, we filed a Registration Statement on Form S-8 (File No. 333-49522) (referred to in this document as the &#147;Fourth Registration Statement&#148;) to register under the Securities Act an additional 1,000,000 shares of our common stock issuable by us under the 1993 Plan. On May 3, 2001 we filed a Registration Statement on Form S-8 (File No. 333- 60168) (referred to in this document as the &#147;Fifth Registration Statement&#148;) to register under the Securities Act an additional 1,000,000 shares of our common stock issuable by us under the Amended and Restated 2000 Equity Incentive Plan (formerly the 2000 Nonstatutory Stock Option Plan), or, the 2000 Equity Incentive Plan and 500,000 shares of our comment stock issuable by us under the 2001 UK Stock Option Plan, or, the 2001 Plan. On May 3, 2001 we also filed a Registration Statement on Form S-8 (File No. 333-60152) (referred to in this document as the &#147;Sixth Registration Statement&#148;) to register under the Securities Act an additional 1,080,359 shares of our common stock issuable by us under the 1993 Plan. On September 18, 2002 we filed a Registration Statement on &nbsp;Form S-8 (File No. 333- 99739) (referred to in this document as the &#147;Seventh Registration Statement&#148;) to register under the Securities Act an additional 697,067 shares of our common stock issuable by us under the 1993 Plan, 1,055,000 shares issuable by us under the 2000 Equity Incentive Plan and 175,000 shares </font><font face="Times New Roman">issuable by us under the 2002 Directors&#146; Stock Option Plan</font><font face="Times New Roman">.&#160; On June 23, 2003 we filed a Registration Statement on Form S-8 (File No. 333-106388) (referred to in this document as the &#147;Eighth Registration Statement&#148;) to register under the Securities Act an additional 60,000 shares of our common stock issuable by us under the 1993 Plan.&#160; On August 10, 2004, we filed a Registration Statement on Form S-8 (File No. 333-118065) (referred to in this document as the &#147;Ninth Registration Statement&#148;) to register under the Securities Act an additional </font><font face="Times New Roman">3,516,564 shares of common stock issuable by us under the 2000 Equity Incentive Plan and 350,000 shares issuable by us under the 2002 Directors&#146; Stock Option Plan.&#160; </font><font face="Times New Roman">On April 21, 2005, we filed a Registration Statement on Form S-8 (File No. 333-124210) (referred to in this document as the &#147;Tenth Registration Statement&#148;) to register under the Securities Act an additional </font><font face="Times New Roman">2,900,000 shares of common stock issuable by us under the 2000 Equity Incentive Plan.</font></p><p style="margin:0in 0in .0001pt;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p><p style="margin:0in 0in .0001pt;text-indent:.5in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">By the terms of the 2000 Equity Incentive Plan, since the time of the filing of the Tenth Registration Statement, the aggregate number of shares of our common stock subject to issuance under the 2000 Equity Incentive Plan automatically increased by 3,046,436 as of January 1, 2006.</font></p><p style="margin:0in 0in .0001pt;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p><p style="margin:0in 0in .0001pt;text-indent:.5in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">This Registration Statement on Form S-8 has been prepared and filed pursuant to and in accordance with the requirements of General Instruction E to Form S-8 for the purpose of effecting the registration under the Securities Act of the additional 3,046,436 shares of our common stock subject to issuance upon exercise of stock options that may be granted under the 2000 Equity Incentive Plan at any time or from time to time after the date hereof under such plan. Pursuant to General Instruction E to Form S-8, the registrant hereby incorporates herein by reference the contents of the First Registration Statement, Second Registration Statement, Third Registration Statement, Fourth Registration Statement, Fifth Registration Statement, Sixth Registration Statement, Seventh Registration Statement, Eighth Registration Statement, Ninth Registration Statement and Tenth Registration Statement.</font></p>

<p align="center" style="letter-spacing:.25pt;margin:0in 0in .0001pt;text-align:center;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>

<p align="center" style="letter-spacing:.25pt;margin:0in 0in .0001pt;text-align:center;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">2</font></p>

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<p align="center" style="letter-spacing:.25pt;margin:0in 0in .0001pt;text-align:center;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>

<p align="center" style="letter-spacing:.25pt;margin:0in 0in .0001pt;text-align:center;"><b><font size="2" face="Times New Roman" style="font-size:10.0pt;font-weight:bold;letter-spacing:0pt;">PART II</font></b></p>

<p align="center" style="letter-spacing:.25pt;margin:0in 0in .0001pt;text-align:center;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>

<p align="center" style="letter-spacing:.25pt;margin:0in 0in .0001pt;text-align:center;"><b><font size="2" face="Times New Roman" style="font-size:10.0pt;font-weight:bold;letter-spacing:0pt;">INFORMATION
REQUIRED IN THE REGISTRATION STATEMENT</font></b></p>

<p style="letter-spacing:.25pt;margin:0in 0in .0001pt;text-align:justify;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>

<p align="left" style="letter-spacing:.25pt;margin:0in 0in .0001pt;text-align:left;"><b><font size="2" face="Times New Roman" style="font-size:10.0pt;font-weight:bold;letter-spacing:0pt;">Item 3.&#160; <i><font style="font-style:italic;">Incorporation of Documents
by Reference.</font></i></font></b></p>

<p style="letter-spacing:.25pt;margin:0in 0in .0001pt;text-align:justify;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>

<p align="left" style="letter-spacing:.25pt;margin:0in 0in .0001pt;text-align:left;text-indent:.5in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;letter-spacing:0pt;">We incorporate by reference the documents listed below and any future
filings we will make with the SEC&nbsp;under&nbsp;Section&nbsp;13(a), 13(c), 14
or 15(d) of the Securities Exchange Act of 1934, as amended:</font></p>

<p align="left" style="letter-spacing:.25pt;margin:0in 0in .0001pt;text-align:left;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>

<p align="left" style="font-size:10.0pt;letter-spacing:.25pt;margin:0in 0in .0001pt 1.0in;text-align:left;text-indent:-.5in;"><font size="3" face="Times New Roman" style="font-size:12.0pt;letter-spacing:0pt;">&#149;</font><font size="1" style="font-size:3.0pt;letter-spacing:0pt;">&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; </font><font style="letter-spacing:0pt;">Annual Report on Form 10-K for the year ended
December 31, 2005;</font></p>

<p align="left" style="letter-spacing:.25pt;margin:0in 0in .0001pt 1.0in;text-align:left;text-indent:-1.0in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>

<p align="left" style="font-size:10.0pt;letter-spacing:.25pt;margin:0in 0in .0001pt 1.0in;text-align:left;text-indent:-.5in;"><font size="3" face="Times New Roman" style="font-size:12.0pt;">&#149;</font><font size="1" style="font-size:3.0pt;">&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; </font>Current
Reports on Form 8-K filed with the SEC on January 27, 2006 and February 1,
2006;</p>

<p align="left" style="letter-spacing:.25pt;margin:0in 0in .0001pt 1.0in;text-align:left;text-indent:-1.0in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>

<p align="left" style="font-size:10.0pt;letter-spacing:.25pt;margin:0in 0in .0001pt 1.0in;text-align:left;text-indent:-.5in;"><font size="3" face="Times New Roman" style="font-size:12.0pt;letter-spacing:0pt;">&#149;</font><font size="1" style="font-size:3.0pt;letter-spacing:0pt;">&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; </font><font style="letter-spacing:0pt;">the description of our common stock contained in our
registration statement on Form 8-A filed with the SEC on September 17, 1996,
including any amendments or reports filed for the purpose of updating that
description; and</font></p>

<p align="left" style="letter-spacing:.25pt;margin:0in 0in .0001pt 1.0in;text-align:left;text-indent:-1.0in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>

<p align="left" style="font-size:10.0pt;letter-spacing:.25pt;margin:0in 0in .0001pt 1.0in;text-align:left;text-indent:-.5in;"><font size="3" face="Times New Roman" style="font-size:12.0pt;letter-spacing:0pt;">&#149;</font><font size="1" style="font-size:3.0pt;letter-spacing:0pt;">&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; </font><font style="letter-spacing:0pt;">the description of the preferred stock purchase
rights for our Series A Junior Participating Preferred Stock contained in our
registration statement on Form 8-A filed with the SEC on August 2, 1999,
including any amendments or reports filed for the purpose of updating that
description.</font></p>

<p align="left" style="letter-spacing:.25pt;margin:0in 0in .0001pt 1.0in;text-align:left;text-indent:-1.0in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>

<p style="letter-spacing:.25pt;margin:0in 0in .0001pt;text-indent:.5in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;letter-spacing:0pt;">You
may request a copy of these filings at no cost (other than exhibits unless those
exhibits are specifically incorporated by reference herein) by writing,
telephoning or e-mailing us at the following address:</font></p>

<p align="left" style="letter-spacing:.25pt;margin:0in 0in .0001pt;text-align:left;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>

<p align="left" style="letter-spacing:.25pt;margin:0in 0in .0001pt 153.0pt;text-align:left;"><font size="2" face="Times New Roman" style="font-size:10.0pt;letter-spacing:0pt;">Cubist Pharmaceuticals, Inc.</font></p>

<p align="left" style="letter-spacing:.25pt;margin:0in 0in .0001pt 153.0pt;text-align:left;"><font size="2" face="Times New Roman" style="font-size:10.0pt;letter-spacing:0pt;">65 Hayden Avenue</font></p>

<p align="left" style="letter-spacing:.25pt;margin:0in 0in .0001pt 153.0pt;text-align:left;"><font size="2" face="Times New Roman" style="font-size:10.0pt;letter-spacing:0pt;">Lexington, MA 02421</font></p>

<p align="left" style="letter-spacing:.25pt;margin:0in 0in .0001pt 153.0pt;text-align:left;"><font size="2" face="Times New Roman" style="font-size:10.0pt;letter-spacing:0pt;">Attn: Investor Relations</font></p>

<p align="left" style="letter-spacing:.25pt;margin:0in 0in .0001pt 153.0pt;text-align:left;"><font size="2" face="Times New Roman" style="font-size:10.0pt;letter-spacing:0pt;">(781) 860-8660</font></p>

<p align="left" style="letter-spacing:.25pt;margin:0in 0in .0001pt 153.0pt;text-align:left;"><font size="2" face="Times New Roman" style="font-size:10.0pt;letter-spacing:0pt;">e-mail: ir@cubist.com</font></p>

<p align="left" style="letter-spacing:.25pt;margin:0in 0in .0001pt;text-align:left;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>

<p align="left" style="letter-spacing:.25pt;margin:0in 0in .0001pt;text-align:left;"><b><font size="2" face="Times New Roman" style="font-size:10.0pt;font-weight:bold;letter-spacing:0pt;">Item 4.&#160; <i><font style="font-style:italic;">Description of Securities</font></i></font></b></p>

<p style="letter-spacing:.25pt;margin:0in 0in .0001pt;text-align:justify;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>

<p align="left" style="letter-spacing:.25pt;margin:0in 0in .0001pt;text-align:left;text-indent:.5in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;letter-spacing:0pt;">Not applicable.</font></p>

<p align="left" style="letter-spacing:.25pt;margin:0in 0in .0001pt;text-align:left;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>

<p align="left" style="letter-spacing:.25pt;margin:0in 0in .0001pt;text-align:left;"><b><font size="2" face="Times New Roman" style="font-size:10.0pt;font-weight:bold;letter-spacing:0pt;">Item 5.&#160; <i><font style="font-style:italic;">Interests of Named Experts
or Counsel</font></i></font></b></p>

<p align="left" style="letter-spacing:.25pt;margin:0in 0in .0001pt;text-align:left;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>

<p align="left" style="letter-spacing:.25pt;margin:0in 0in .0001pt;text-align:left;text-indent:.5in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;letter-spacing:0pt;">Not applicable.</font></p>

<p align="left" style="letter-spacing:.25pt;margin:0in 0in .0001pt;text-align:left;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>

<p align="left" style="letter-spacing:.25pt;margin:0in 0in .0001pt;text-align:left;"><b><font size="2" face="Times New Roman" style="font-size:10.0pt;font-weight:bold;letter-spacing:0pt;">Item 6.&#160; <i><font style="font-style:italic;">Indemnification of
Directors and Officers</font></i></font></b></p>

<p align="left" style="letter-spacing:.25pt;margin:0in 0in .0001pt;text-align:left;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>

<p align="left" style="letter-spacing:.25pt;margin:0in 0in .0001pt;text-align:left;text-indent:.5in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;letter-spacing:0pt;">Section 145 of the Delaware General Corporation Law empowers a Delaware
corporation to indemnify its officers and directors and certain other persons
to the extent and under the circumstances set forth therein.</font></p>

<p align="left" style="letter-spacing:.25pt;margin:0in 0in .0001pt;text-align:left;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>

<p align="left" style="letter-spacing:.25pt;margin:0in 0in .0001pt;text-align:left;text-indent:.5in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;letter-spacing:0pt;">The Restated Certificate of Incorporation and the Amended and Restated
By-Laws of Cubist, copies of which are filed herein as Exhibits 3.1 and 3.2,
provide for advancement of expenses and indemnification of officers and
directors of Cubist and certain other persons against liabilities and expenses
incurred by any of them in certain stated proceedings and under certain stated
conditions to the fullest extent permissible under Delaware law.</font></p>

<p align="left" style="letter-spacing:.25pt;margin:0in 0in .0001pt;text-align:left;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>

<p align="left" style="letter-spacing:.25pt;margin:0in 0in .0001pt;text-align:left;text-indent:.5in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;letter-spacing:0pt;">Cubist intends to maintain insurance for the benefit
of its directors and officers insuring such persons against certain
liabilities, including liabilities under the securities laws.</font></p>

<p align="center" style="letter-spacing:.25pt;margin:0in 0in .0001pt;text-align:center;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>

<p align="center" style="letter-spacing:.25pt;margin:0in 0in .0001pt;text-align:center;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">3</font></p>

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<p align="left" style="letter-spacing:.25pt;margin:0in 0in .0001pt;text-align:left;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>

<p align="left" style="letter-spacing:.25pt;margin:0in 0in .0001pt;text-align:left;"><b><font size="2" face="Times New Roman" style="font-size:10.0pt;font-weight:bold;letter-spacing:0pt;">Item 7.&#160; <i><font style="font-style:italic;">Exemption from
Registration Claimed</font></i></font></b></p>

<p align="left" style="letter-spacing:.25pt;margin:0in 0in .0001pt;text-align:left;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>

<p align="left" style="letter-spacing:.25pt;margin:0in 0in .0001pt;text-align:left;text-indent:.5in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;letter-spacing:0pt;">Not applicable.</font></p>

<p align="left" style="letter-spacing:.25pt;margin:0in 0in .0001pt;text-align:left;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>

<p align="left" style="letter-spacing:.25pt;margin:0in 0in .0001pt;text-align:left;"><b><font size="2" face="Times New Roman" style="font-size:10.0pt;font-weight:bold;letter-spacing:0pt;">Item 8.&#160; <i><font style="font-style:italic;">Exhibits</font></i></font></b></p>

<p align="left" style="letter-spacing:.25pt;margin:0in 0in .0001pt;text-align:left;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>

<p align="left" style="letter-spacing:.25pt;margin:0in 0in .0001pt;text-align:left;text-indent:.5in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;letter-spacing:0pt;">The following exhibits are filed as part of this registration statement:</font></p>

<p align="left" style="letter-spacing:.25pt;margin:0in 0in .0001pt;text-align:left;"><font size="2" face="Times New Roman" style="font-size:10.0pt;letter-spacing:0pt;">&nbsp;</font></p>

<table border="0" cellspacing="0" cellpadding="0" width="90%" style="border-collapse:collapse;margin-left:.25in;width:90.0%;">
 <tr>
  <td width="7%" valign="top" style="padding:0in 0in 0in 0in;width:7.88%;">
  <p align="left" style="letter-spacing:.25pt;margin:0in 0in .0001pt 20.0pt;text-align:left;text-indent:-10.0pt;"><font size="2" face="Times New Roman" style="font-size:10.0pt;letter-spacing:0pt;">3.1</font></p>
  </td>
  <td width="92%" valign="top" style="padding:0in 0in 0in 0in;width:92.12%;">
  <p align="left" style="letter-spacing:.25pt;margin:0in 0in .0001pt;text-align:left;"><font size="2" face="Times New Roman" style="font-size:10.0pt;letter-spacing:0pt;">Restated
  Certificate of Incorporation Cubist (incorporated by reference to Exhibit 3
  to Cubist&#146;s Quarterly Report on Form 10-Q filed on August 6, 2004) (File no.
  000-21379).</font></p>
  </td>
 </tr>
 <tr>
  <td width="7%" valign="top" style="padding:0in 0in 0in 0in;width:7.88%;">
  <p align="left" style="letter-spacing:.25pt;margin:0in 0in .0001pt 20.0pt;text-align:left;text-indent:-10.0pt;"><font size="2" face="Times New Roman" style="font-size:10.0pt;letter-spacing:0pt;">&nbsp;</font></p>
  </td>
  <td width="92%" valign="top" style="padding:0in 0in 0in 0in;width:92.12%;">
  <p align="left" style="letter-spacing:.25pt;margin:0in 0in .0001pt;text-align:left;"><font size="2" face="Times New Roman" style="font-size:10.0pt;letter-spacing:0pt;">&nbsp;</font></p>
  </td>
 </tr>
 <tr>
  <td width="7%" valign="top" style="padding:0in 0in 0in 0in;width:7.88%;">
  <p align="left" style="letter-spacing:.25pt;margin:0in 0in .0001pt 20.0pt;text-align:left;text-indent:-10.0pt;"><font size="2" face="Times New Roman" style="font-size:10.0pt;letter-spacing:0pt;">3.2</font></p>
  </td>
  <td width="92%" valign="top" style="padding:0in 0in 0in 0in;width:92.12%;">
  <p align="left" style="letter-spacing:.25pt;margin:0in 0in .0001pt;text-align:left;"><font size="2" face="Times New Roman" style="font-size:10.0pt;letter-spacing:0pt;">Amended
  and Restated By-Laws of Cubist, as amended to date. (incorporated by
  reference to Exhibit 3.4, Registration No. 333-06795).</font></p>
  </td>
 </tr>
 <tr>
  <td width="7%" valign="top" style="padding:0in 0in 0in 0in;width:7.88%;">
  <p align="left" style="letter-spacing:.25pt;margin:0in 0in .0001pt 20.0pt;text-align:left;text-indent:-10.0pt;"><font size="2" face="Times New Roman" style="font-size:10.0pt;letter-spacing:0pt;">&nbsp;</font></p>
  </td>
  <td width="92%" valign="top" style="padding:0in 0in 0in 0in;width:92.12%;">
  <p align="left" style="letter-spacing:.25pt;margin:0in 0in .0001pt;text-align:left;"><font size="2" face="Times New Roman" style="font-size:10.0pt;letter-spacing:0pt;">&nbsp;</font></p>
  </td>
 </tr>
 <tr>
  <td width="7%" valign="top" style="padding:0in 0in 0in 0in;width:7.88%;">
  <p align="left" style="letter-spacing:.25pt;margin:0in 0in .0001pt 20.0pt;text-align:left;text-indent:-10.0pt;"><font size="2" face="Times New Roman" style="font-size:10.0pt;letter-spacing:0pt;">4.1</font></p>
  </td>
  <td width="92%" valign="top" style="padding:0in 0in 0in 0in;width:92.12%;">
  <p align="left" style="letter-spacing:.25pt;margin:0in 0in .0001pt;text-align:left;"><font size="2" face="Times New Roman" style="font-size:10.0pt;letter-spacing:0pt;">Specimen
  certificate for shares of Common Stock (incorporated by reference to Exhibit
  4.1 to Cubist&#146;s Annual Report on Form 10-K filed on March 1, 2006)
  (Registration No. 000-21379).</font></p>
  </td>
 </tr>
 <tr>
  <td width="7%" valign="top" style="padding:0in 0in 0in 0in;width:7.88%;">
  <p align="left" style="letter-spacing:.25pt;margin:0in 0in .0001pt 20.0pt;text-align:left;text-indent:-10.0pt;"><font size="2" face="Times New Roman" style="font-size:10.0pt;letter-spacing:0pt;">&nbsp;</font></p>
  </td>
  <td width="92%" valign="top" style="padding:0in 0in 0in 0in;width:92.12%;">
  <p align="left" style="letter-spacing:.25pt;margin:0in 0in .0001pt;text-align:left;"><font size="2" face="Times New Roman" style="font-size:10.0pt;letter-spacing:0pt;">&nbsp;</font></p>
  </td>
 </tr>
 <tr>
  <td width="7%" valign="top" style="padding:0in 0in 0in 0in;width:7.88%;">
  <p align="left" style="letter-spacing:.25pt;margin:0in 0in .0001pt 20.0pt;text-align:left;text-indent:-10.0pt;"><font size="2" face="Times New Roman" style="font-size:10.0pt;letter-spacing:0pt;">4.2</font></p>
  </td>
  <td width="92%" valign="top" style="padding:0in 0in 0in 0in;width:92.12%;">
  <p align="left" style="font-size:10.0pt;letter-spacing:.25pt;margin:0in 0in .0001pt;text-align:left;"><font size="2" face="Times New Roman"><font style="font-size:10.0pt;letter-spacing:0pt;">Rights
  Agreement dated as of July 21, 1999 between Cubist and Computershare Trust
  Company N.A. (f/k/a </font>EquiServe Trust Company, N.A. f/k/a Fleet National
  Bank f/k/a BankBoston, N.A.), </font><font style="letter-spacing:0pt;">as
  Rights Agent (incorporated herein by reference to Exhibit 4.1 to the
  Company&#146;s Registration Statement on Form 8-A/A filed on August 5, 2005) (File
  No. 000-21379).</font></p>
  </td>
 </tr>
 <tr>
  <td width="7%" valign="top" style="padding:0in 0in 0in 0in;width:7.88%;">
  <p align="left" style="letter-spacing:.25pt;margin:0in 0in .0001pt 20.0pt;text-align:left;text-indent:-10.0pt;"><font size="2" face="Times New Roman" style="font-size:10.0pt;letter-spacing:0pt;">&nbsp;</font></p>
  </td>
  <td width="92%" valign="top" style="padding:0in 0in 0in 0in;width:92.12%;">
  <p align="left" style="letter-spacing:.25pt;margin:0in 0in .0001pt;text-align:left;"><font size="2" face="Times New Roman" style="font-size:10.0pt;letter-spacing:0pt;">&nbsp;</font></p>
  </td>
 </tr>
 <tr>
  <td width="7%" valign="top" style="padding:0in 0in 0in 0in;width:7.88%;">
  <p align="left" style="letter-spacing:.25pt;margin:0in 0in .0001pt 20.0pt;text-align:left;text-indent:-10.0pt;"><font size="2" face="Times New Roman" style="font-size:10.0pt;letter-spacing:0pt;">4.3</font></p>
  </td>
  <td width="92%" valign="top" style="padding:0in 0in 0in 0in;width:92.12%;">
  <p align="left" style="font-size:10.0pt;letter-spacing:.25pt;margin:0in 0in .0001pt;text-align:left;"><font size="2" face="Times New Roman"><font style="font-size:10.0pt;letter-spacing:0pt;">First
  Amendment, dated as of March 7, 2000, to the Rights Agreement, dated as of
  July 21, 1999 between the Company and Computershare Trust Company N.A. (f/k/a
  </font>EquiServe Trust Company, N.A. f/k/a Fleet National Bank f/k/a
  BankBoston, N.A.)</font><font style="letter-spacing:0pt;">, as Rights Agent
  (incorporated herein by reference to Exhibit 4.2 to the Company&#146;s
  Registration Statement on Form 8-A/A filed on August 5, 2005) (File No.
  000-21379).</font></p>
  </td>
 </tr>
 <tr>
  <td width="7%" valign="top" style="padding:0in 0in 0in 0in;width:7.88%;">
  <p align="left" style="letter-spacing:.25pt;margin:0in 0in .0001pt 20.0pt;text-align:left;text-indent:-10.0pt;"><font size="2" face="Times New Roman" style="font-size:10.0pt;letter-spacing:0pt;">&nbsp;</font></p>
  </td>
  <td width="92%" valign="top" style="padding:0in 0in 0in 0in;width:92.12%;">
  <p align="left" style="letter-spacing:.25pt;margin:0in 0in .0001pt;text-align:left;"><font size="2" face="Times New Roman" style="font-size:10.0pt;letter-spacing:0pt;">&nbsp;</font></p>
  </td>
 </tr>
 <tr>
  <td width="7%" valign="top" style="padding:0in 0in 0in 0in;width:7.88%;">
  <p align="left" style="letter-spacing:.25pt;margin:0in 0in .0001pt 20.0pt;text-align:left;text-indent:-10.0pt;"><font size="2" face="Times New Roman" style="font-size:10.0pt;letter-spacing:0pt;">4.4</font></p>
  </td>
  <td width="92%" valign="top" style="padding:0in 0in 0in 0in;width:92.12%;">
  <p align="left" style="font-size:10.0pt;letter-spacing:.25pt;margin:0in 0in .0001pt;text-align:left;"><font size="2" face="Times New Roman"><font style="font-size:10.0pt;letter-spacing:0pt;">Amendment,
  dated as of March 20, 2002, to the Rights Agreement, dated as of July 21,
  1999 between the Company and Computershare Trust Company N.A. (f/k/a </font>EquiServe
  Trust Company, N.A. f/k/a Fleet National Bank f/k/a BankBoston, N.A.)</font><font style="letter-spacing:0pt;">, as Rights Agent (incorporated herein by
  reference to Exhibit 4.3 to the Company&#146;s Registration Statement on Form
  8-A/A filed on August 5, 2005) (File No. 000-21379).</font></p>
  </td>
 </tr>
 <tr>
  <td width="7%" valign="top" style="padding:0in 0in 0in 0in;width:7.88%;">
  <p align="left" style="letter-spacing:.25pt;margin:0in 0in .0001pt 20.0pt;text-align:left;text-indent:-10.0pt;"><font size="2" face="Times New Roman" style="font-size:10.0pt;letter-spacing:0pt;">&nbsp;</font></p>
  </td>
  <td width="92%" valign="top" style="padding:0in 0in 0in 0in;width:92.12%;">
  <p align="left" style="letter-spacing:.25pt;margin:0in 0in .0001pt;text-align:left;"><font size="2" face="Times New Roman" style="font-size:10.0pt;letter-spacing:0pt;">&nbsp;</font></p>
  </td>
 </tr>
 <tr>
  <td width="7%" valign="top" style="padding:0in 0in 0in 0in;width:7.88%;">
  <p align="left" style="letter-spacing:.25pt;margin:0in 0in .0001pt 20.0pt;text-align:left;text-indent:-10.0pt;"><font size="2" face="Times New Roman" style="font-size:10.0pt;letter-spacing:0pt;">4.5</font></p>
  </td>
  <td width="92%" valign="top" style="padding:0in 0in 0in 0in;width:92.12%;">
  <p align="left" style="font-size:10.0pt;letter-spacing:.25pt;margin:0in 0in .0001pt;text-align:left;"><font size="2" face="Times New Roman"><font style="font-size:10.0pt;letter-spacing:0pt;">Third
  Amendment, dated as of August 2, 2005, to the Rights Agreement, dated as of
  July 21, 1999 between the Company and Computershare Trust Company N.A. (f/k/a
  </font>EquiServe Trust Company, N.A. f/k/a Fleet National Bank f/k/a
  BankBoston, N.A.)</font><font style="letter-spacing:0pt;">, as Rights Agent
  (incorporated herein by reference to Exhibit 4.4 to the Company&#146;s
  Registration Statement on Form 8-A/A filed on August 5, 2005) (File No.
  000-21379).</font></p>
  </td>
 </tr>
 <tr>
  <td width="7%" valign="top" style="padding:0in 0in 0in 0in;width:7.88%;">
  <p align="left" style="letter-spacing:.25pt;margin:0in 0in .0001pt 20.0pt;text-align:left;text-indent:-10.0pt;"><font size="2" face="Times New Roman" style="font-size:10.0pt;letter-spacing:0pt;">&nbsp;</font></p>
  </td>
  <td width="92%" valign="top" style="padding:0in 0in 0in 0in;width:92.12%;">
  <p align="left" style="letter-spacing:.25pt;margin:0in 0in .0001pt;text-align:left;"><font size="2" face="Times New Roman" style="font-size:10.0pt;letter-spacing:0pt;">&nbsp;</font></p>
  </td>
 </tr>
 <tr>
  <td width="7%" valign="top" style="padding:0in 0in 0in 0in;width:7.88%;">
  <p align="left" style="letter-spacing:.25pt;margin:0in 0in .0001pt 20.0pt;text-align:left;text-indent:-10.0pt;"><font size="2" face="Times New Roman" style="font-size:10.0pt;letter-spacing:0pt;">4.6</font></p>
  </td>
  <td width="92%" valign="top" style="padding:0in 0in 0in 0in;width:92.12%;">
  <p align="left" style="letter-spacing:.25pt;margin:0in 0in .0001pt;text-align:left;"><font size="2" face="Times New Roman" style="font-size:10.0pt;letter-spacing:0pt;">Form
  of Amended Rights Certificate (incorporated herein by reference to Exhibit
  4.4 to the Company&#146;s Registration Statement on Form 8-A/A filed on March 9,
  2000) (File No. 000-21379).</font></p>
  </td>
 </tr>
 <tr>
  <td width="7%" valign="top" style="padding:0in 0in 0in 0in;width:7.88%;">
  <p align="left" style="letter-spacing:.25pt;margin:0in 0in .0001pt 20.0pt;text-align:left;text-indent:-10.0pt;"><font size="2" face="Times New Roman" style="font-size:10.0pt;letter-spacing:0pt;">&nbsp;</font></p>
  </td>
  <td width="92%" valign="top" style="padding:0in 0in 0in 0in;width:92.12%;">
  <p align="left" style="letter-spacing:.25pt;margin:0in 0in .0001pt;text-align:left;"><font size="2" face="Times New Roman" style="font-size:10.0pt;letter-spacing:0pt;">&nbsp;</font></p>
  </td>
 </tr>
 <tr>
  <td width="7%" valign="top" style="padding:0in 0in 0in 0in;width:7.88%;">
  <p align="left" style="letter-spacing:.25pt;margin:0in 0in .0001pt 20.0pt;text-align:left;text-indent:-10.0pt;"><font size="2" face="Times New Roman" style="font-size:10.0pt;letter-spacing:0pt;">5</font></p>
  </td>
  <td width="92%" valign="top" style="padding:0in 0in 0in 0in;width:92.12%;">
  <p align="left" style="letter-spacing:.25pt;margin:0in 0in .0001pt;text-align:left;"><font size="2" face="Times New Roman" style="font-size:10.0pt;letter-spacing:0pt;">Opinion
  of Bingham McCutchen LLP with respect to the legality of the shares being
  registered.</font></p>
  </td>
 </tr>
 <tr>
  <td width="7%" valign="top" style="padding:0in 0in 0in 0in;width:7.88%;">
  <p align="left" style="letter-spacing:.25pt;margin:0in 0in .0001pt 20.0pt;text-align:left;text-indent:-10.0pt;"><font size="2" face="Times New Roman" style="font-size:10.0pt;letter-spacing:0pt;">&nbsp;</font></p>
  </td>
  <td width="92%" valign="top" style="padding:0in 0in 0in 0in;width:92.12%;">
  <p align="left" style="letter-spacing:.25pt;margin:0in 0in .0001pt;text-align:left;"><font size="2" face="Times New Roman" style="font-size:10.0pt;letter-spacing:0pt;">&nbsp;</font></p>
  </td>
 </tr>
 <tr>
  <td width="7%" valign="top" style="padding:0in 0in 0in 0in;width:7.88%;">
  <p align="left" style="letter-spacing:.25pt;margin:0in 0in .0001pt 20.0pt;text-align:left;text-indent:-10.0pt;"><font size="2" face="Times New Roman" style="font-size:10.0pt;letter-spacing:0pt;">23.1</font></p>
  </td>
  <td width="92%" valign="top" style="padding:0in 0in 0in 0in;width:92.12%;">
  <p align="left" style="letter-spacing:.25pt;margin:0in 0in .0001pt;text-align:left;"><font size="2" face="Times New Roman" style="font-size:10.0pt;letter-spacing:0pt;">Consent
  of Bingham McCutchen LLP (included in Exhibit 5).</font></p>
  </td>
 </tr>
 <tr>
  <td width="7%" valign="top" style="padding:0in 0in 0in 0in;width:7.88%;">
  <p align="left" style="letter-spacing:.25pt;margin:0in 0in .0001pt 20.0pt;text-align:left;text-indent:-10.0pt;"><font size="2" face="Times New Roman" style="font-size:10.0pt;letter-spacing:0pt;">&nbsp;</font></p>
  </td>
  <td width="92%" valign="top" style="padding:0in 0in 0in 0in;width:92.12%;">
  <p align="left" style="letter-spacing:.25pt;margin:0in 0in .0001pt;text-align:left;"><font size="2" face="Times New Roman" style="font-size:10.0pt;letter-spacing:0pt;">&nbsp;</font></p>
  </td>
 </tr>
 <tr>
  <td width="7%" valign="top" style="padding:0in 0in 0in 0in;width:7.88%;">
  <p align="left" style="letter-spacing:.25pt;margin:0in 0in .0001pt 20.0pt;text-align:left;text-indent:-10.0pt;"><font size="2" face="Times New Roman" style="font-size:10.0pt;letter-spacing:0pt;">23.2</font></p>
  </td>
  <td width="92%" valign="top" style="padding:0in 0in 0in 0in;width:92.12%;">
  <p align="left" style="font-size:10.0pt;letter-spacing:.25pt;margin:0in 0in .0001pt;text-align:left;"><font size="2" face="Times New Roman"><font style="font-size:10.0pt;letter-spacing:0pt;">Consent
  of </font>Independent Registered Public Accounting Firm</font><font style="letter-spacing:0pt;">.</font></p>
  </td>
 </tr>
 <tr>
  <td width="7%" valign="top" style="padding:0in 0in 0in 0in;width:7.88%;">
  <p align="left" style="letter-spacing:.25pt;margin:0in 0in .0001pt 20.0pt;text-align:left;text-indent:-10.0pt;"><font size="2" face="Times New Roman" style="font-size:10.0pt;letter-spacing:0pt;">&nbsp;</font></p>
  </td>
  <td width="92%" valign="top" style="padding:0in 0in 0in 0in;width:92.12%;">
  <p align="left" style="letter-spacing:.25pt;margin:0in 0in .0001pt;text-align:left;"><font size="2" face="Times New Roman" style="font-size:10.0pt;letter-spacing:0pt;">&nbsp;</font></p>
  </td>
 </tr>
 <tr>
  <td width="7%" valign="top" style="padding:0in 0in 0in 0in;width:7.88%;">
  <p align="left" style="letter-spacing:.25pt;margin:0in 0in .0001pt 20.0pt;text-align:left;text-indent:-10.0pt;"><font size="2" face="Times New Roman" style="font-size:10.0pt;letter-spacing:0pt;">24</font></p>
  </td>
  <td width="92%" valign="top" style="padding:0in 0in 0in 0in;width:92.12%;">
  <p align="left" style="letter-spacing:.25pt;margin:0in 0in .0001pt;text-align:left;"><font size="2" face="Times New Roman" style="font-size:10.0pt;letter-spacing:0pt;">Power
  of Attorney (included in signature page to registration statement).</font></p>
  </td>
 </tr>
</table>

<p align="center" style="letter-spacing:.25pt;margin:0in 0in .0001pt;text-align:center;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>

<p align="center" style="letter-spacing:.25pt;margin:0in 0in .0001pt;text-align:center;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">4</font></p>

<div align="left" style="letter-spacing:.25pt;margin:0in 0in .0001pt;text-align:left;"><hr size="2" width="100%" noshade color="gray" align="left"></div>

</div>
<!-- SEQ.=1,FOLIO='4',FILE='C:\JMS\jvangc\06-6429-1\task883451\6429-1-ba.htm',USER='jvangb',CD='Mar  7 03:40 2006' -->


<br clear="all" style="page-break-before:always;">


<div style="font-family:Times New Roman;">

<p align="left" style="letter-spacing:.25pt;margin:0in 0in .0001pt 94.5pt;text-align:left;text-indent:-94.5pt;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>

<p align="left" style="letter-spacing:.25pt;margin:0in 0in .0001pt;text-align:left;"><b><font size="2" face="Times New Roman" style="font-size:10.0pt;font-weight:bold;letter-spacing:0pt;">Item 9.&#160; <i><font style="font-style:italic;">Undertakings</font></i></font></b></p>

<p style="letter-spacing:.25pt;margin:0in 0in .0001pt;text-align:justify;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>

<p align="left" style="letter-spacing:.25pt;margin:0in 0in .0001pt;text-align:left;text-indent:.5in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;letter-spacing:0pt;">The undersigned registrant hereby undertakes:</font></p>

<p style="letter-spacing:.25pt;margin:0in 0in .0001pt;text-align:justify;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>

<p align="left" style="font-size:10.0pt;letter-spacing:.25pt;margin:0in 0in .0001pt .5in;text-align:left;text-indent:-.5in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;letter-spacing:0pt;">(1)</font><font size="1" style="font-size:3.0pt;letter-spacing:0pt;">&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; </font><font style="letter-spacing:0pt;">To file, during any period in which offers or sales
are being made, a post-effective amendment to this registration statement to
include any material information with respect to the plan of distribution not
previously disclosed in this registration statement or any material change to
such information in this registration statement;</font></p>

<p align="left" style="letter-spacing:.25pt;margin:0in 0in .0001pt .5in;text-align:left;text-indent:-.5in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>

<p align="left" style="font-size:10.0pt;letter-spacing:.25pt;margin:0in 0in .0001pt .5in;text-align:left;text-indent:-.5in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;letter-spacing:0pt;">(2)</font><font size="1" style="font-size:3.0pt;letter-spacing:0pt;">&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; </font><font style="letter-spacing:0pt;">That, for the purpose of determining any liability
under the Securities Act of 1933, each such post-effective amendment shall be
deemed to be a new registration statement relating to the securities offered
therein, and the offering of such securities at that time shall be deemed to be
the initial <i><font style="font-style:italic;">bona fide</font></i> offering thereof;</font></p>

<p align="left" style="letter-spacing:.25pt;margin:0in 0in .0001pt .5in;text-align:left;text-indent:-.5in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>

<p align="left" style="font-size:10.0pt;letter-spacing:.25pt;margin:0in 0in .0001pt .5in;text-align:left;text-indent:-.5in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;letter-spacing:0pt;">(3)</font><font size="1" style="font-size:3.0pt;letter-spacing:0pt;">&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; </font><font style="letter-spacing:0pt;">To remove from registration by means of a
post-effective amendment any of the securities being registered which remain
unsold at the termination of the offering;</font></p>

<p align="left" style="letter-spacing:.25pt;margin:0in 0in .0001pt .5in;text-align:left;text-indent:-.5in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>

<p align="left" style="font-size:10.0pt;letter-spacing:.25pt;margin:0in 0in .0001pt .5in;text-align:left;text-indent:-.5in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;letter-spacing:0pt;">(4)</font><font size="1" style="font-size:3.0pt;letter-spacing:0pt;">&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; </font><font style="letter-spacing:0pt;">That, for purposes of determining any liability
under the Securities Act of 1933, each filing of the registrant&#146;s annual report
pursuant to Section 13(a) or 15(d) of the Exchange Act of 1934 (and, where
applicable, each filing of an employee benefit plan&#146;s annual report pursuant to
Section 15(d) of the Exchange Act of 1934) that is incorporated by reference in
this registration statement shall be deemed to be a new registration statement
relating to the securities offered therein, and the offering of such securities
at that time shall be deemed to be the initial <i><font style="font-style:italic;">bona fide</font></i>
offering thereof; and</font></p>

<p align="left" style="letter-spacing:.25pt;margin:0in 0in .0001pt .5in;text-align:left;text-indent:-.5in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>

<p align="left" style="font-size:10.0pt;letter-spacing:.25pt;margin:0in 0in .0001pt .5in;text-align:left;text-indent:-.5in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;letter-spacing:0pt;">(5)</font><font size="1" style="font-size:3.0pt;letter-spacing:0pt;">&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; </font><font style="letter-spacing:0pt;">Insofar as indemnification for liabilities arising
under the Securities Act of 1933 may be permitted to directors, officers and
controlling persons of the registrant pursuant to the foregoing provisions, or
otherwise, the registrant has been advised that in the opinion of the
Securities and Exchange Commission such indemnification is against public
policy as expressed in the Securities Act and is, therefore,
unenforceable.&#160; In the event that a claim
for indemnification against such liabilities (other than the payment by the
registrant of expenses incurred or paid by a director, officer or controlling
person of the registrant in the successful defense of any action, suit or
proceeding) is asserted by such director, officer or controlling person in
connection with the securities being registered, the registrant will, unless in
the opinion of its counsel the matter has been settled by controlling
precedent, submit to a court of appropriate jurisdiction the question whether
such indemnification by it is against public policy as expressed in the
Securities Act and will be governed by the final adjudication of such issue.</font></p>

<p align="center" style="letter-spacing:.25pt;margin:0in 0in .0001pt;text-align:center;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>

<p align="center" style="letter-spacing:.25pt;margin:0in 0in .0001pt;text-align:center;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">5</font></p>

<div align="left" style="letter-spacing:.25pt;margin:0in 0in .0001pt;text-align:left;"><hr size="2" width="100%" noshade color="gray" align="left"></div>

</div>
<!-- SEQ.=1,FOLIO='5',FILE='C:\JMS\jvangc\06-6429-1\task883451\6429-1-ba.htm',USER='jvangb',CD='Mar  7 03:40 2006' -->


<br clear="all" style="page-break-before:always;">


<div style="font-family:Times New Roman;">

<p align="center" style="letter-spacing:.25pt;margin:0in 0in .0001pt;text-align:center;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>

<p align="center" style="letter-spacing:.25pt;margin:0in 0in .0001pt;text-align:center;"><b><font size="2" face="Times New Roman" style="font-size:10.0pt;font-weight:bold;letter-spacing:0pt;">SIGNATURES</font></b></p>

<p align="center" style="letter-spacing:.25pt;margin:0in 0in .0001pt;text-align:center;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>

<p align="left" style="letter-spacing:.25pt;margin:0in 0in .0001pt;text-align:left;text-indent:.5in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;letter-spacing:0pt;">Pursuant to the requirements of the Securities Act of 1933, as amended,
the registrant, Cubist Pharmaceuticals, Inc., certifies that it has reasonable
grounds to believe that it meets all of the requirements for filing on Form S-8
and has duly caused this registration statement to be signed on its behalf by
the undersigned, thereunto duly authorized, in the Town of Lexington,
Commonwealth of Massachusetts, on this 7th day of March, 2006.</font></p>

<p align="center" style="letter-spacing:.25pt;margin:0in 0in .0001pt;text-align:center;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>

<table border="0" cellspacing="0" cellpadding="0" width="100%" style="border-collapse:collapse;width:100.0%;">
 <tr>
  <td width="42%" valign="top" style="padding:0in 0in 0in 0in;width:42.34%;">
  <p align="left" style="letter-spacing:.25pt;margin:0in 0in .0001pt;text-align:left;"><font size="2" face="Times New Roman" style="font-size:1.0pt;">&nbsp;</font></p>
  </td>
  <td width="57%" colspan="3" valign="top" style="padding:0in 0in 0in 0in;width:57.66%;">
  <p align="left" style="letter-spacing:.25pt;margin:0in 0in .0001pt;text-align:left;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">CUBIST PHARMACEUTICALS,
  INC.</font></p>
  </td>
 </tr>
 <tr>
  <td width="42%" valign="top" style="padding:0in 0in 0in 0in;width:42.34%;">
  <p align="left" style="letter-spacing:.25pt;margin:0in 0in .0001pt;text-align:left;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>
  </td>
  <td width="57%" colspan="3" valign="top" style="padding:0in 0in 0in 0in;width:57.66%;">
  <p align="left" style="letter-spacing:.25pt;margin:0in 0in .0001pt;text-align:left;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>
  </td>
 </tr>
 <tr>
  <td width="42%" valign="top" style="padding:0in 0in 0in 0in;width:42.34%;">
  <p align="left" style="letter-spacing:.25pt;margin:0in 0in .0001pt;text-align:left;"><font size="2" face="Times New Roman" style="font-size:1.0pt;">&nbsp;</font></p>
  </td>
  <td width="6%" valign="top" style="padding:0in 0in 0in 0in;width:6.66%;">
  <p align="left" style="letter-spacing:.25pt;margin:0in 0in .0001pt;text-align:left;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">By:</font></p>
  </td>
  <td width="26%" valign="top" style="border:none;border-bottom:solid windowtext 1.0pt;padding:0in 0in 0in 0in;width:26.0%;">
  <p align="left" style="letter-spacing:.25pt;margin:0in 0in .0001pt;text-align:left;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">/s/ Michael W. Bonney </font></p>
  </td>
  <td width="25%" valign="top" style="padding:0in 0in 0in 0in;width:25.0%;">
  <p align="left" style="letter-spacing:.25pt;margin:0in 0in .0001pt;text-align:left;"><font size="2" face="Times New Roman" style="font-size:1.0pt;">&nbsp;</font></p>
  </td>
 </tr>
 <tr>
  <td width="42%" valign="top" style="padding:0in 0in 0in 0in;width:42.34%;">
  <p align="left" style="letter-spacing:.25pt;margin:0in 0in .0001pt;text-align:left;"><font size="2" face="Times New Roman" style="font-size:1.0pt;">&nbsp;</font></p>
  </td>
  <td width="6%" valign="top" style="padding:0in 0in 0in 0in;width:6.66%;">
  <p align="left" style="letter-spacing:.25pt;margin:0in 0in .0001pt;text-align:left;"><font size="2" face="Times New Roman" style="font-size:1.0pt;">&nbsp;</font></p>
  </td>
  <td width="51%" colspan="2" valign="top" style="padding:0in 0in 0in 0in;width:51.0%;">
  <p align="left" style="letter-spacing:.25pt;margin:0in 0in .0001pt;text-align:left;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">Michael W. Bonney </font></p>
  </td>
 </tr>
 <tr>
  <td width="42%" valign="top" style="padding:0in 0in 0in 0in;width:42.34%;">
  <p align="left" style="letter-spacing:.25pt;margin:0in 0in .0001pt;text-align:left;"><font size="2" face="Times New Roman" style="font-size:1.0pt;">&nbsp;</font></p>
  </td>
  <td width="6%" valign="top" style="padding:0in 0in 0in 0in;width:6.66%;">
  <p align="left" style="letter-spacing:.25pt;margin:0in 0in .0001pt;text-align:left;"><font size="2" face="Times New Roman" style="font-size:1.0pt;">&nbsp;</font></p>
  </td>
  <td width="51%" colspan="2" valign="top" style="padding:0in 0in 0in 0in;width:51.0%;">
  <p align="left" style="letter-spacing:.25pt;margin:0in 0in .0001pt;text-align:left;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">President and Chief
  Executive Officer</font></p>
  </td>
 </tr>
</table>

<p align="center" style="letter-spacing:.25pt;margin:0in 0in .0001pt;text-align:center;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>

<p align="center" style="letter-spacing:.25pt;margin:0in 0in .0001pt;text-align:center;"><b><font size="2" face="Times New Roman" style="font-size:10.0pt;font-weight:bold;letter-spacing:0pt;">POWER OF
ATTORNEY</font></b></p>

<p align="center" style="letter-spacing:.25pt;margin:0in 0in .0001pt;text-align:center;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>

<p align="left" style="font-size:10.0pt;letter-spacing:.25pt;margin:0in 0in .0001pt;text-align:left;text-indent:.5in;"><font size="2" face="Times New Roman"><font style="font-size:10.0pt;letter-spacing:0pt;">Each person whose signature appears below hereby appoints each of </font>Michael
W. Bonney and David W.J. McGirr severally</font><font style="letter-spacing:0pt;">, acting alone and without the other, his true and lawful attorney-in-fact
with the authority to execute in the name of each such person, and to file with
the Securities and Exchange Commission, together with any exhibits thereto and
other documents therewith, any and all amendments (including without limitation
post-effective amendments) to this registration statement on Form S-8 necessary
or advisable to enable the registrant to comply with the Securities Act of
1933, as amended, and any rules, regulations, and requirements of the
Securities and Exchange Commission in respect thereof, which amendments may
make such other changes in the Registration Statement as the aforesaid
attorney-in-fact executing the same deems appropriate.</font></p>

<p align="left" style="letter-spacing:.25pt;margin:0in 0in .0001pt;text-align:left;text-indent:.5in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>

<p align="left" style="margin:0in 0in .0001pt;text-align:left;text-indent:.5in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">Pursuant
to the requirements of the Securities Act of 1933, as amended, this
registration statement has been signed by the following persons in the
capacities and on the date indicated.</font></p>

<p align="left" style="letter-spacing:.25pt;margin:0in 0in .0001pt;text-align:left;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>

<table border="0" cellspacing="0" cellpadding="0" width="100%" style="border-collapse:collapse;width:100.0%;">
 <tr>
  <td width="30%" colspan="2" valign="top" style="border:none;border-bottom:solid windowtext 1.0pt;padding:0in 0in 0in 0in;width:30.78%;">
  <p align="left" style="letter-spacing:.25pt;margin:0in 0in .0001pt;text-align:left;"><b><font size="1" face="Times New Roman" style="font-size:8.0pt;font-weight:bold;">Signature</font></b></p>
  </td>
  <td width="2%" valign="top" style="padding:0in 0in 0in 0in;width:2.02%;">
  <p align="left" style="letter-spacing:.25pt;margin:0in 0in .0001pt;text-align:left;"><b><font size="1" face="Times New Roman" style="font-size:1.0pt;font-weight:bold;">&nbsp;</font></b></p>
  </td>
  <td width="49%" valign="top" style="border:none;border-bottom:solid windowtext 1.0pt;padding:0in 0in 0in 0in;width:49.54%;">
  <p align="center" style="letter-spacing:.25pt;margin:0in 0in .0001pt;text-align:center;"><b><font size="1" face="Times New Roman" style="font-size:8.0pt;font-weight:bold;">Title</font></b></p>
  </td>
  <td width="2%" valign="top" style="padding:0in 0in 0in 0in;width:2.0%;">
  <p align="left" style="letter-spacing:.25pt;margin:0in 0in .0001pt;text-align:left;"><b><font size="1" face="Times New Roman" style="font-size:1.0pt;font-weight:bold;">&nbsp;</font></b></p>
  </td>
  <td width="15%" valign="top" style="border:none;border-bottom:solid windowtext 1.0pt;padding:0in 0in 0in 0in;width:15.66%;">
  <p align="center" style="letter-spacing:.25pt;margin:0in 0in .0001pt;text-align:center;"><b><font size="1" face="Times New Roman" style="font-size:8.0pt;font-weight:bold;">Date</font></b></p>
  </td>
 </tr>
 <tr>
  <td width="30%" colspan="2" valign="top" style="border:none;padding:0in 0in 0in 0in;width:30.78%;">
  <p align="left" style="letter-spacing:.25pt;margin:0in 0in .0001pt;text-align:left;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>
  </td>
  <td width="2%" valign="top" style="padding:0in 0in 0in 0in;width:2.02%;">
  <p align="left" style="letter-spacing:.25pt;margin:0in 0in .0001pt;text-align:left;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>
  </td>
  <td width="49%" valign="top" style="border:none;padding:0in 0in 0in 0in;width:49.54%;">
  <p align="left" style="letter-spacing:.25pt;margin:0in 0in .0001pt;text-align:left;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>
  </td>
  <td width="2%" valign="top" style="padding:0in 0in 0in 0in;width:2.0%;">
  <p align="left" style="letter-spacing:.25pt;margin:0in 0in .0001pt;text-align:left;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>
  </td>
  <td width="15%" valign="top" style="border:none;padding:0in 0in 0in 0in;width:15.66%;">
  <p align="center" style="letter-spacing:.25pt;margin:0in 0in .0001pt;text-align:center;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>
  </td>
 </tr>
 <tr>
  <td width="21%" valign="top" style="border:none;border-bottom:solid windowtext 1.0pt;padding:0in 0in 0in 0in;width:21.5%;">
  <p align="left" style="letter-spacing:.25pt;margin:0in 0in .0001pt;text-align:left;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;/s/ Michael W. Bonney </font></p>
  </td>
  <td width="9%" valign="top" style="padding:0in 0in 0in 0in;width:9.28%;">
  <p align="left" style="letter-spacing:.25pt;margin:0in 0in .0001pt;text-align:left;"><font size="2" face="Times New Roman" style="font-size:1.0pt;">&nbsp;</font></p>
  </td>
  <td width="2%" valign="top" style="padding:0in 0in 0in 0in;width:2.02%;">
  <p align="left" style="letter-spacing:.25pt;margin:0in 0in .0001pt;text-align:left;"><font size="2" face="Times New Roman" style="font-size:1.0pt;">&nbsp;</font></p>
  </td>
  <td width="49%" valign="top" style="padding:0in 0in 0in 0in;width:49.54%;">
  <p align="left" style="letter-spacing:.25pt;margin:0in 0in .0001pt;text-align:left;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">President, Chief
  Executive Officer and </font></p>
  </td>
  <td width="2%" valign="top" style="padding:0in 0in 0in 0in;width:2.0%;">
  <p align="left" style="letter-spacing:.25pt;margin:0in 0in .0001pt;text-align:left;"><font size="2" face="Times New Roman" style="font-size:1.0pt;">&nbsp;</font></p>
  </td>
  <td width="15%" valign="top" style="padding:0in 0in 0in 0in;width:15.66%;">
  <p align="center" style="letter-spacing:.25pt;margin:0in 0in .0001pt;text-align:center;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">March 7, 2006</font></p>
  </td>
 </tr>
 <tr>
  <td width="30%" colspan="2" valign="top" style="padding:0in 0in 0in 0in;width:30.78%;">
  <p align="left" style="letter-spacing:.25pt;margin:0in 0in .0001pt;text-align:left;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">Michael W.
  Bonney</font></p>
  </td>
  <td width="2%" valign="top" style="padding:0in 0in 0in 0in;width:2.02%;">
  <p align="left" style="letter-spacing:.25pt;margin:0in 0in .0001pt;text-align:left;"><font size="2" face="Times New Roman" style="font-size:1.0pt;">&nbsp;</font></p>
  </td>
  <td width="49%" valign="top" style="padding:0in 0in 0in 0in;width:49.54%;">
  <p align="left" style="letter-spacing:.25pt;margin:0in 0in .0001pt;text-align:left;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">Director </font></p>
  </td>
  <td width="2%" valign="top" style="padding:0in 0in 0in 0in;width:2.0%;">
  <p align="left" style="letter-spacing:.25pt;margin:0in 0in .0001pt;text-align:left;"><font size="2" face="Times New Roman" style="font-size:1.0pt;">&nbsp;</font></p>
  </td>
  <td width="15%" valign="top" style="padding:0in 0in 0in 0in;width:15.66%;">
  <p align="center" style="letter-spacing:.25pt;margin:0in 0in .0001pt;text-align:center;"><font size="2" face="Times New Roman" style="font-size:1.0pt;">&nbsp;</font></p>
  </td>
 </tr>
 <tr>
  <td width="30%" colspan="2" valign="top" style="padding:0in 0in 0in 0in;width:30.78%;">
  <p align="left" style="letter-spacing:.25pt;margin:0in 0in .0001pt;text-align:left;"><font size="2" face="Times New Roman" style="font-size:1.0pt;">&nbsp;</font></p>
  </td>
  <td width="2%" valign="top" style="padding:0in 0in 0in 0in;width:2.02%;">
  <p align="left" style="letter-spacing:.25pt;margin:0in 0in .0001pt;text-align:left;"><font size="2" face="Times New Roman" style="font-size:1.0pt;">&nbsp;</font></p>
  </td>
  <td width="49%" valign="top" style="padding:0in 0in 0in 0in;width:49.54%;">
  <p align="left" style="letter-spacing:.25pt;margin:0in 0in .0001pt;text-align:left;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">(Principal
  Executive Officer)</font></p>
  </td>
  <td width="2%" valign="top" style="padding:0in 0in 0in 0in;width:2.0%;">
  <p align="left" style="letter-spacing:.25pt;margin:0in 0in .0001pt;text-align:left;"><font size="2" face="Times New Roman" style="font-size:1.0pt;">&nbsp;</font></p>
  </td>
  <td width="15%" valign="top" style="padding:0in 0in 0in 0in;width:15.66%;">
  <p align="center" style="letter-spacing:.25pt;margin:0in 0in .0001pt;text-align:center;"><font size="2" face="Times New Roman" style="font-size:1.0pt;">&nbsp;</font></p>
  </td>
 </tr>
 <tr>
  <td width="30%" colspan="2" valign="top" style="padding:0in 0in 0in 0in;width:30.78%;">
  <p align="left" style="letter-spacing:.25pt;margin:0in 0in .0001pt;text-align:left;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>
  </td>
  <td width="2%" valign="top" style="padding:0in 0in 0in 0in;width:2.02%;">
  <p align="left" style="letter-spacing:.25pt;margin:0in 0in .0001pt;text-align:left;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>
  </td>
  <td width="49%" valign="top" style="padding:0in 0in 0in 0in;width:49.54%;">
  <p align="left" style="letter-spacing:.25pt;margin:0in 0in .0001pt;text-align:left;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>
  </td>
  <td width="2%" valign="top" style="padding:0in 0in 0in 0in;width:2.0%;">
  <p align="left" style="letter-spacing:.25pt;margin:0in 0in .0001pt;text-align:left;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>
  </td>
  <td width="15%" valign="top" style="padding:0in 0in 0in 0in;width:15.66%;">
  <p align="center" style="letter-spacing:.25pt;margin:0in 0in .0001pt;text-align:center;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>
  </td>
 </tr>
 <tr>
  <td width="21%" valign="top" style="border:none;border-bottom:solid windowtext 1.0pt;padding:0in 0in 0in 0in;width:21.5%;">
  <p align="left" style="letter-spacing:.25pt;margin:0in 0in .0001pt;text-align:left;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">/s/ David W.J.
  McGirr </font></p>
  </td>
  <td width="9%" valign="top" style="padding:0in 0in 0in 0in;width:9.28%;">
  <p align="left" style="letter-spacing:.25pt;margin:0in 0in .0001pt;text-align:left;"><font size="2" face="Times New Roman" style="font-size:1.0pt;">&nbsp;</font></p>
  </td>
  <td width="2%" valign="top" style="padding:0in 0in 0in 0in;width:2.02%;">
  <p align="left" style="letter-spacing:.25pt;margin:0in 0in .0001pt;text-align:left;"><font size="2" face="Times New Roman" style="font-size:1.0pt;">&nbsp;</font></p>
  </td>
  <td width="49%" valign="top" style="padding:0in 0in 0in 0in;width:49.54%;">
  <p align="left" style="letter-spacing:.25pt;margin:0in 0in .0001pt;text-align:left;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">Senior Vice
  President </font></p>
  </td>
  <td width="2%" valign="top" style="padding:0in 0in 0in 0in;width:2.0%;">
  <p align="left" style="letter-spacing:.25pt;margin:0in 0in .0001pt;text-align:left;"><font size="2" face="Times New Roman" style="font-size:1.0pt;">&nbsp;</font></p>
  </td>
  <td width="15%" valign="top" style="padding:0in 0in 0in 0in;width:15.66%;">
  <p align="center" style="letter-spacing:.25pt;margin:0in 0in .0001pt;text-align:center;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">March 7, 2006</font></p>
  </td>
 </tr>
 <tr>
  <td width="30%" colspan="2" valign="top" style="padding:0in 0in 0in 0in;width:30.78%;">
  <p align="left" style="letter-spacing:.25pt;margin:0in 0in .0001pt;text-align:left;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">David W.J.
  McGirr</font></p>
  </td>
  <td width="2%" valign="top" style="padding:0in 0in 0in 0in;width:2.02%;">
  <p align="left" style="letter-spacing:.25pt;margin:0in 0in .0001pt;text-align:left;"><font size="2" face="Times New Roman" style="font-size:1.0pt;">&nbsp;</font></p>
  </td>
  <td width="49%" valign="top" style="padding:0in 0in 0in 0in;width:49.54%;">
  <p align="left" style="letter-spacing:.25pt;margin:0in 0in .0001pt;text-align:left;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">and Chief
  Financial Officer </font></p>
  </td>
  <td width="2%" valign="top" style="padding:0in 0in 0in 0in;width:2.0%;">
  <p align="left" style="letter-spacing:.25pt;margin:0in 0in .0001pt;text-align:left;"><font size="2" face="Times New Roman" style="font-size:1.0pt;">&nbsp;</font></p>
  </td>
  <td width="15%" valign="top" style="padding:0in 0in 0in 0in;width:15.66%;">
  <p align="center" style="letter-spacing:.25pt;margin:0in 0in .0001pt;text-align:center;"><font size="2" face="Times New Roman" style="font-size:1.0pt;">&nbsp;</font></p>
  </td>
 </tr>
 <tr>
  <td width="30%" colspan="2" valign="top" style="padding:0in 0in 0in 0in;width:30.78%;">
  <p align="left" style="letter-spacing:.25pt;margin:0in 0in .0001pt;text-align:left;"><font size="2" face="Times New Roman" style="font-size:1.0pt;">&nbsp;</font></p>
  </td>
  <td width="2%" valign="top" style="padding:0in 0in 0in 0in;width:2.02%;">
  <p align="left" style="letter-spacing:.25pt;margin:0in 0in .0001pt;text-align:left;"><font size="2" face="Times New Roman" style="font-size:1.0pt;">&nbsp;</font></p>
  </td>
  <td width="49%" valign="top" style="padding:0in 0in 0in 0in;width:49.54%;">
  <p align="left" style="letter-spacing:.25pt;margin:0in 0in .0001pt;text-align:left;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">(Principal
  Financial and Accounting Officer)</font></p>
  </td>
  <td width="2%" valign="top" style="padding:0in 0in 0in 0in;width:2.0%;">
  <p align="left" style="letter-spacing:.25pt;margin:0in 0in .0001pt;text-align:left;"><font size="2" face="Times New Roman" style="font-size:1.0pt;">&nbsp;</font></p>
  </td>
  <td width="15%" valign="top" style="padding:0in 0in 0in 0in;width:15.66%;">
  <p align="center" style="letter-spacing:.25pt;margin:0in 0in .0001pt;text-align:center;"><font size="2" face="Times New Roman" style="font-size:1.0pt;">&nbsp;</font></p>
  </td>
 </tr>
 <tr>
  <td width="30%" colspan="2" valign="top" style="padding:0in 0in 0in 0in;width:30.78%;">
  <p align="left" style="letter-spacing:.25pt;margin:0in 0in .0001pt;text-align:left;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>
  </td>
  <td width="2%" valign="top" style="padding:0in 0in 0in 0in;width:2.02%;">
  <p align="left" style="letter-spacing:.25pt;margin:0in 0in .0001pt;text-align:left;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>
  </td>
  <td width="49%" valign="top" style="padding:0in 0in 0in 0in;width:49.54%;">
  <p align="left" style="letter-spacing:.25pt;margin:0in 0in .0001pt;text-align:left;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>
  </td>
  <td width="2%" valign="top" style="padding:0in 0in 0in 0in;width:2.0%;">
  <p align="left" style="letter-spacing:.25pt;margin:0in 0in .0001pt;text-align:left;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>
  </td>
  <td width="15%" valign="top" style="padding:0in 0in 0in 0in;width:15.66%;">
  <p align="center" style="letter-spacing:.25pt;margin:0in 0in .0001pt;text-align:center;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>
  </td>
 </tr>
 <tr>
  <td width="21%" valign="top" style="border:none;border-bottom:solid windowtext 1.0pt;padding:0in 0in 0in 0in;width:21.5%;">
  <p align="left" style="letter-spacing:.25pt;margin:0in 0in .0001pt;text-align:left;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">/s/ Kenneth M.
  Bate </font></p>
  </td>
  <td width="9%" valign="top" style="padding:0in 0in 0in 0in;width:9.28%;">
  <p align="left" style="letter-spacing:.25pt;margin:0in 0in .0001pt;text-align:left;"><font size="2" face="Times New Roman" style="font-size:1.0pt;">&nbsp;</font></p>
  </td>
  <td width="2%" valign="top" style="padding:0in 0in 0in 0in;width:2.02%;">
  <p align="left" style="letter-spacing:.25pt;margin:0in 0in .0001pt;text-align:left;"><font size="2" face="Times New Roman" style="font-size:1.0pt;">&nbsp;</font></p>
  </td>
  <td width="49%" valign="top" style="padding:0in 0in 0in 0in;width:49.54%;">
  <p align="left" style="letter-spacing:.25pt;margin:0in 0in .0001pt;text-align:left;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">Director</font></p>
  </td>
  <td width="2%" valign="top" style="padding:0in 0in 0in 0in;width:2.0%;">
  <p align="left" style="letter-spacing:.25pt;margin:0in 0in .0001pt;text-align:left;"><font size="2" face="Times New Roman" style="font-size:1.0pt;">&nbsp;</font></p>
  </td>
  <td width="15%" valign="top" style="padding:0in 0in 0in 0in;width:15.66%;">
  <p align="center" style="letter-spacing:.25pt;margin:0in 0in .0001pt;text-align:center;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">March 7, 2006</font></p>
  </td>
 </tr>
 <tr>
  <td width="30%" colspan="2" valign="top" style="padding:0in 0in 0in 0in;width:30.78%;">
  <p align="left" style="letter-spacing:.25pt;margin:0in 0in .0001pt;text-align:left;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">Kenneth M. Bate</font></p>
  </td>
  <td width="2%" valign="top" style="padding:0in 0in 0in 0in;width:2.02%;">
  <p align="left" style="letter-spacing:.25pt;margin:0in 0in .0001pt;text-align:left;"><font size="2" face="Times New Roman" style="font-size:1.0pt;">&nbsp;</font></p>
  </td>
  <td width="49%" valign="top" style="padding:0in 0in 0in 0in;width:49.54%;">
  <p align="left" style="letter-spacing:.25pt;margin:0in 0in .0001pt;text-align:left;"><font size="2" face="Times New Roman" style="font-size:1.0pt;">&nbsp;</font></p>
  </td>
  <td width="2%" valign="top" style="padding:0in 0in 0in 0in;width:2.0%;">
  <p align="left" style="letter-spacing:.25pt;margin:0in 0in .0001pt;text-align:left;"><font size="2" face="Times New Roman" style="font-size:1.0pt;">&nbsp;</font></p>
  </td>
  <td width="15%" valign="top" style="padding:0in 0in 0in 0in;width:15.66%;">
  <p align="center" style="letter-spacing:.25pt;margin:0in 0in .0001pt;text-align:center;"><font size="2" face="Times New Roman" style="font-size:1.0pt;">&nbsp;</font></p>
  </td>
 </tr>
 <tr>
  <td width="30%" colspan="2" valign="top" style="padding:0in 0in 0in 0in;width:30.78%;">
  <p align="left" style="letter-spacing:.25pt;margin:0in 0in .0001pt;text-align:left;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>
  </td>
  <td width="2%" valign="top" style="padding:0in 0in 0in 0in;width:2.02%;">
  <p align="left" style="letter-spacing:.25pt;margin:0in 0in .0001pt;text-align:left;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>
  </td>
  <td width="49%" valign="top" style="padding:0in 0in 0in 0in;width:49.54%;">
  <p align="left" style="letter-spacing:.25pt;margin:0in 0in .0001pt;text-align:left;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>
  </td>
  <td width="2%" valign="top" style="padding:0in 0in 0in 0in;width:2.0%;">
  <p align="left" style="letter-spacing:.25pt;margin:0in 0in .0001pt;text-align:left;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>
  </td>
  <td width="15%" valign="top" style="padding:0in 0in 0in 0in;width:15.66%;">
  <p align="center" style="letter-spacing:.25pt;margin:0in 0in .0001pt;text-align:center;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>
  </td>
 </tr>
 <tr>
  <td width="21%" valign="top" style="border:none;border-bottom:solid windowtext 1.0pt;padding:0in 0in 0in 0in;width:21.5%;">
  <p align="left" style="letter-spacing:.25pt;margin:0in 0in .0001pt;text-align:left;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">/s/ David W.
  Martin, Jr. </font></p>
  </td>
  <td width="9%" valign="top" style="padding:0in 0in 0in 0in;width:9.28%;">
  <p align="left" style="letter-spacing:.25pt;margin:0in 0in .0001pt;text-align:left;"><font size="2" face="Times New Roman" style="font-size:1.0pt;">&nbsp;</font></p>
  </td>
  <td width="2%" valign="top" style="padding:0in 0in 0in 0in;width:2.02%;">
  <p align="left" style="letter-spacing:.25pt;margin:0in 0in .0001pt;text-align:left;"><font size="2" face="Times New Roman" style="font-size:1.0pt;">&nbsp;</font></p>
  </td>
  <td width="49%" valign="top" style="padding:0in 0in 0in 0in;width:49.54%;">
  <p align="left" style="letter-spacing:.25pt;margin:0in 0in .0001pt;text-align:left;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">Director</font></p>
  </td>
  <td width="2%" valign="top" style="padding:0in 0in 0in 0in;width:2.0%;">
  <p align="left" style="letter-spacing:.25pt;margin:0in 0in .0001pt;text-align:left;"><font size="2" face="Times New Roman" style="font-size:1.0pt;">&nbsp;</font></p>
  </td>
  <td width="15%" valign="top" style="padding:0in 0in 0in 0in;width:15.66%;">
  <p align="center" style="letter-spacing:.25pt;margin:0in 0in .0001pt;text-align:center;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">March 7, 2006</font></p>
  </td>
 </tr>
 <tr>
  <td width="30%" colspan="2" valign="top" style="padding:0in 0in 0in 0in;width:30.78%;">
  <p align="left" style="letter-spacing:.25pt;margin:0in 0in .0001pt;text-align:left;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">David W. Martin,
  Jr.</font></p>
  </td>
  <td width="2%" valign="top" style="padding:0in 0in 0in 0in;width:2.02%;">
  <p align="left" style="letter-spacing:.25pt;margin:0in 0in .0001pt;text-align:left;"><font size="2" face="Times New Roman" style="font-size:1.0pt;">&nbsp;</font></p>
  </td>
  <td width="49%" valign="top" style="padding:0in 0in 0in 0in;width:49.54%;">
  <p align="left" style="letter-spacing:.25pt;margin:0in 0in .0001pt;text-align:left;"><font size="2" face="Times New Roman" style="font-size:1.0pt;">&nbsp;</font></p>
  </td>
  <td width="2%" valign="top" style="padding:0in 0in 0in 0in;width:2.0%;">
  <p align="left" style="letter-spacing:.25pt;margin:0in 0in .0001pt;text-align:left;"><font size="2" face="Times New Roman" style="font-size:1.0pt;">&nbsp;</font></p>
  </td>
  <td width="15%" valign="top" style="padding:0in 0in 0in 0in;width:15.66%;">
  <p align="center" style="letter-spacing:.25pt;margin:0in 0in .0001pt;text-align:center;"><font size="2" face="Times New Roman" style="font-size:1.0pt;">&nbsp;</font></p>
  </td>
 </tr>
 <tr>
  <td width="30%" colspan="2" valign="top" style="padding:0in 0in 0in 0in;width:30.78%;">
  <p align="left" style="letter-spacing:.25pt;margin:0in 0in .0001pt;text-align:left;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>
  </td>
  <td width="2%" valign="top" style="padding:0in 0in 0in 0in;width:2.02%;">
  <p align="left" style="letter-spacing:.25pt;margin:0in 0in .0001pt;text-align:left;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>
  </td>
  <td width="49%" valign="top" style="padding:0in 0in 0in 0in;width:49.54%;">
  <p align="left" style="letter-spacing:.25pt;margin:0in 0in .0001pt;text-align:left;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>
  </td>
  <td width="2%" valign="top" style="padding:0in 0in 0in 0in;width:2.0%;">
  <p align="left" style="letter-spacing:.25pt;margin:0in 0in .0001pt;text-align:left;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>
  </td>
  <td width="15%" valign="top" style="padding:0in 0in 0in 0in;width:15.66%;">
  <p align="center" style="letter-spacing:.25pt;margin:0in 0in .0001pt;text-align:center;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>
  </td>
 </tr>
 <tr>
  <td width="21%" valign="top" style="border:none;border-bottom:solid windowtext 1.0pt;padding:0in 0in 0in 0in;width:21.5%;">
  <p align="left" style="letter-spacing:.25pt;margin:0in 0in .0001pt;text-align:left;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">/s/ Walter R.
  Maupay, Jr. </font></p>
  </td>
  <td width="9%" valign="top" style="padding:0in 0in 0in 0in;width:9.28%;">
  <p align="left" style="letter-spacing:.25pt;margin:0in 0in .0001pt;text-align:left;"><font size="2" face="Times New Roman" style="font-size:1.0pt;">&nbsp;</font></p>
  </td>
  <td width="2%" valign="top" style="padding:0in 0in 0in 0in;width:2.02%;">
  <p align="left" style="letter-spacing:.25pt;margin:0in 0in .0001pt;text-align:left;"><font size="2" face="Times New Roman" style="font-size:1.0pt;">&nbsp;</font></p>
  </td>
  <td width="49%" valign="top" style="padding:0in 0in 0in 0in;width:49.54%;">
  <p align="left" style="letter-spacing:.25pt;margin:0in 0in .0001pt;text-align:left;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">Director</font></p>
  </td>
  <td width="2%" valign="top" style="padding:0in 0in 0in 0in;width:2.0%;">
  <p align="left" style="letter-spacing:.25pt;margin:0in 0in .0001pt;text-align:left;"><font size="2" face="Times New Roman" style="font-size:1.0pt;">&nbsp;</font></p>
  </td>
  <td width="15%" valign="top" style="padding:0in 0in 0in 0in;width:15.66%;">
  <p align="center" style="letter-spacing:.25pt;margin:0in 0in .0001pt;text-align:center;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">March 7, 2006</font></p>
  </td>
 </tr>
 <tr>
  <td width="30%" colspan="2" valign="top" style="padding:0in 0in 0in 0in;width:30.78%;">
  <p align="left" style="letter-spacing:.25pt;margin:0in 0in .0001pt;text-align:left;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">Walter R.
  Maupay, Jr.</font></p>
  </td>
  <td width="2%" valign="top" style="padding:0in 0in 0in 0in;width:2.02%;">
  <p align="left" style="letter-spacing:.25pt;margin:0in 0in .0001pt;text-align:left;"><font size="2" face="Times New Roman" style="font-size:1.0pt;">&nbsp;</font></p>
  </td>
  <td width="49%" valign="top" style="padding:0in 0in 0in 0in;width:49.54%;">
  <p align="left" style="letter-spacing:.25pt;margin:0in 0in .0001pt;text-align:left;"><font size="2" face="Times New Roman" style="font-size:1.0pt;">&nbsp;</font></p>
  </td>
  <td width="2%" valign="top" style="padding:0in 0in 0in 0in;width:2.0%;">
  <p align="left" style="letter-spacing:.25pt;margin:0in 0in .0001pt;text-align:left;"><font size="2" face="Times New Roman" style="font-size:1.0pt;">&nbsp;</font></p>
  </td>
  <td width="15%" valign="top" style="padding:0in 0in 0in 0in;width:15.66%;">
  <p align="center" style="letter-spacing:.25pt;margin:0in 0in .0001pt;text-align:center;"><font size="2" face="Times New Roman" style="font-size:1.0pt;">&nbsp;</font></p>
  </td>
 </tr>
 <tr>
  <td width="30%" colspan="2" valign="top" style="padding:0in 0in 0in 0in;width:30.78%;">
  <p align="left" style="letter-spacing:.25pt;margin:0in 0in .0001pt;text-align:left;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>
  </td>
  <td width="2%" valign="top" style="padding:0in 0in 0in 0in;width:2.02%;">
  <p align="left" style="letter-spacing:.25pt;margin:0in 0in .0001pt;text-align:left;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>
  </td>
  <td width="49%" valign="top" style="padding:0in 0in 0in 0in;width:49.54%;">
  <p align="left" style="letter-spacing:.25pt;margin:0in 0in .0001pt;text-align:left;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>
  </td>
  <td width="2%" valign="top" style="padding:0in 0in 0in 0in;width:2.0%;">
  <p align="left" style="letter-spacing:.25pt;margin:0in 0in .0001pt;text-align:left;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>
  </td>
  <td width="15%" valign="top" style="padding:0in 0in 0in 0in;width:15.66%;">
  <p align="center" style="letter-spacing:.25pt;margin:0in 0in .0001pt;text-align:center;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>
  </td>
 </tr>
 <tr>
  <td width="21%" valign="top" style="border:none;border-bottom:solid windowtext 1.0pt;padding:0in 0in 0in 0in;width:21.5%;">
  <p align="left" style="letter-spacing:.25pt;margin:0in 0in .0001pt;text-align:left;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">/s/ Martin
  Rosenberg </font></p>
  </td>
  <td width="9%" valign="top" style="padding:0in 0in 0in 0in;width:9.28%;">
  <p align="left" style="letter-spacing:.25pt;margin:0in 0in .0001pt;text-align:left;"><font size="2" face="Times New Roman" style="font-size:1.0pt;">&nbsp;</font></p>
  </td>
  <td width="2%" valign="top" style="padding:0in 0in 0in 0in;width:2.02%;">
  <p align="left" style="letter-spacing:.25pt;margin:0in 0in .0001pt;text-align:left;"><font size="2" face="Times New Roman" style="font-size:1.0pt;">&nbsp;</font></p>
  </td>
  <td width="49%" valign="top" style="padding:0in 0in 0in 0in;width:49.54%;">
  <p align="left" style="letter-spacing:.25pt;margin:0in 0in .0001pt;text-align:left;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">Director</font></p>
  </td>
  <td width="2%" valign="top" style="padding:0in 0in 0in 0in;width:2.0%;">
  <p align="left" style="letter-spacing:.25pt;margin:0in 0in .0001pt;text-align:left;"><font size="2" face="Times New Roman" style="font-size:1.0pt;">&nbsp;</font></p>
  </td>
  <td width="15%" valign="top" style="padding:0in 0in 0in 0in;width:15.66%;">
  <p align="center" style="letter-spacing:.25pt;margin:0in 0in .0001pt;text-align:center;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">March 7, 2006</font></p>
  </td>
 </tr>
 <tr>
  <td width="30%" colspan="2" valign="top" style="padding:0in 0in 0in 0in;width:30.78%;">
  <p align="left" style="letter-spacing:.25pt;margin:0in 0in .0001pt;text-align:left;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">Martin Rosenberg</font></p>
  </td>
  <td width="2%" valign="top" style="padding:0in 0in 0in 0in;width:2.02%;">
  <p align="left" style="letter-spacing:.25pt;margin:0in 0in .0001pt;text-align:left;"><font size="2" face="Times New Roman" style="font-size:1.0pt;">&nbsp;</font></p>
  </td>
  <td width="49%" valign="top" style="padding:0in 0in 0in 0in;width:49.54%;">
  <p align="left" style="letter-spacing:.25pt;margin:0in 0in .0001pt;text-align:left;"><font size="2" face="Times New Roman" style="font-size:1.0pt;">&nbsp;</font></p>
  </td>
  <td width="2%" valign="top" style="padding:0in 0in 0in 0in;width:2.0%;">
  <p align="left" style="letter-spacing:.25pt;margin:0in 0in .0001pt;text-align:left;"><font size="2" face="Times New Roman" style="font-size:1.0pt;">&nbsp;</font></p>
  </td>
  <td width="15%" valign="top" style="padding:0in 0in 0in 0in;width:15.66%;">
  <p align="center" style="letter-spacing:.25pt;margin:0in 0in .0001pt;text-align:center;"><font size="2" face="Times New Roman" style="font-size:1.0pt;">&nbsp;</font></p>
  </td>
 </tr>
 <tr>
  <td width="30%" colspan="2" valign="top" style="padding:0in 0in 0in 0in;width:30.78%;">
  <p align="left" style="letter-spacing:.25pt;margin:0in 0in .0001pt;text-align:left;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>
  </td>
  <td width="2%" valign="top" style="padding:0in 0in 0in 0in;width:2.02%;">
  <p align="left" style="letter-spacing:.25pt;margin:0in 0in .0001pt;text-align:left;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>
  </td>
  <td width="49%" valign="top" style="padding:0in 0in 0in 0in;width:49.54%;">
  <p align="left" style="letter-spacing:.25pt;margin:0in 0in .0001pt;text-align:left;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>
  </td>
  <td width="2%" valign="top" style="padding:0in 0in 0in 0in;width:2.0%;">
  <p align="left" style="letter-spacing:.25pt;margin:0in 0in .0001pt;text-align:left;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>
  </td>
  <td width="15%" valign="top" style="padding:0in 0in 0in 0in;width:15.66%;">
  <p align="center" style="letter-spacing:.25pt;margin:0in 0in .0001pt;text-align:center;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>
  </td>
 </tr>
 <tr>
  <td width="21%" valign="top" style="border:none;border-bottom:solid windowtext 1.0pt;padding:0in 0in 0in 0in;width:21.5%;">
  <p align="left" style="letter-spacing:.25pt;margin:0in 0in .0001pt;text-align:left;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">/s/ J. Matthew
  Singleton </font></p>
  </td>
  <td width="9%" valign="top" style="padding:0in 0in 0in 0in;width:9.28%;">
  <p align="left" style="letter-spacing:.25pt;margin:0in 0in .0001pt;text-align:left;"><font size="2" face="Times New Roman" style="font-size:1.0pt;">&nbsp;</font></p>
  </td>
  <td width="2%" valign="top" style="padding:0in 0in 0in 0in;width:2.02%;">
  <p align="left" style="letter-spacing:.25pt;margin:0in 0in .0001pt;text-align:left;"><font size="2" face="Times New Roman" style="font-size:1.0pt;">&nbsp;</font></p>
  </td>
  <td width="49%" valign="top" style="padding:0in 0in 0in 0in;width:49.54%;">
  <p align="left" style="letter-spacing:.25pt;margin:0in 0in .0001pt;text-align:left;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">Director</font></p>
  </td>
  <td width="2%" valign="top" style="padding:0in 0in 0in 0in;width:2.0%;">
  <p align="left" style="letter-spacing:.25pt;margin:0in 0in .0001pt;text-align:left;"><font size="2" face="Times New Roman" style="font-size:1.0pt;">&nbsp;</font></p>
  </td>
  <td width="15%" valign="top" style="padding:0in 0in 0in 0in;width:15.66%;">
  <p align="center" style="letter-spacing:.25pt;margin:0in 0in .0001pt;text-align:center;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">March 7, 2006</font></p>
  </td>
 </tr>
 <tr>
  <td width="30%" colspan="2" valign="top" style="padding:0in 0in 0in 0in;width:30.78%;">
  <p align="left" style="letter-spacing:.25pt;margin:0in 0in .0001pt;text-align:left;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">J. Matthew
  Singleton</font></p>
  </td>
  <td width="2%" valign="top" style="padding:0in 0in 0in 0in;width:2.02%;">
  <p align="left" style="letter-spacing:.25pt;margin:0in 0in .0001pt;text-align:left;"><font size="2" face="Times New Roman" style="font-size:1.0pt;">&nbsp;</font></p>
  </td>
  <td width="49%" valign="top" style="padding:0in 0in 0in 0in;width:49.54%;">
  <p align="left" style="letter-spacing:.25pt;margin:0in 0in .0001pt;text-align:left;"><font size="2" face="Times New Roman" style="font-size:1.0pt;">&nbsp;</font></p>
  </td>
  <td width="2%" valign="top" style="padding:0in 0in 0in 0in;width:2.0%;">
  <p align="left" style="letter-spacing:.25pt;margin:0in 0in .0001pt;text-align:left;"><font size="2" face="Times New Roman" style="font-size:1.0pt;">&nbsp;</font></p>
  </td>
  <td width="15%" valign="top" style="padding:0in 0in 0in 0in;width:15.66%;">
  <p align="center" style="letter-spacing:.25pt;margin:0in 0in .0001pt;text-align:center;"><font size="2" face="Times New Roman" style="font-size:1.0pt;">&nbsp;</font></p>
  </td>
 </tr>
 <tr>
  <td width="30%" colspan="2" valign="top" style="padding:0in 0in 0in 0in;width:30.78%;">
  <p align="left" style="letter-spacing:.25pt;margin:0in 0in .0001pt;text-align:left;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>
  </td>
  <td width="2%" valign="top" style="padding:0in 0in 0in 0in;width:2.02%;">
  <p align="left" style="letter-spacing:.25pt;margin:0in 0in .0001pt;text-align:left;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>
  </td>
  <td width="49%" valign="top" style="padding:0in 0in 0in 0in;width:49.54%;">
  <p align="left" style="letter-spacing:.25pt;margin:0in 0in .0001pt;text-align:left;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>
  </td>
  <td width="2%" valign="top" style="padding:0in 0in 0in 0in;width:2.0%;">
  <p align="left" style="letter-spacing:.25pt;margin:0in 0in .0001pt;text-align:left;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>
  </td>
  <td width="15%" valign="top" style="padding:0in 0in 0in 0in;width:15.66%;">
  <p align="center" style="letter-spacing:.25pt;margin:0in 0in .0001pt;text-align:center;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>
  </td>
 </tr>
 <tr>
  <td width="21%" valign="top" style="border:none;border-bottom:solid windowtext 1.0pt;padding:0in 0in 0in 0in;width:21.5%;">
  <p align="left" style="letter-spacing:.25pt;margin:0in 0in .0001pt;text-align:left;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">/s/ Michael B.
  Wood </font></p>
  </td>
  <td width="9%" valign="top" style="padding:0in 0in 0in 0in;width:9.28%;">
  <p align="left" style="letter-spacing:.25pt;margin:0in 0in .0001pt;text-align:left;"><font size="2" face="Times New Roman" style="font-size:1.0pt;">&nbsp;</font></p>
  </td>
  <td width="2%" valign="top" style="padding:0in 0in 0in 0in;width:2.02%;">
  <p align="left" style="letter-spacing:.25pt;margin:0in 0in .0001pt;text-align:left;"><font size="2" face="Times New Roman" style="font-size:1.0pt;">&nbsp;</font></p>
  </td>
  <td width="49%" valign="top" style="padding:0in 0in 0in 0in;width:49.54%;">
  <p align="left" style="letter-spacing:.25pt;margin:0in 0in .0001pt;text-align:left;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">Director</font></p>
  </td>
  <td width="2%" valign="top" style="padding:0in 0in 0in 0in;width:2.0%;">
  <p align="left" style="letter-spacing:.25pt;margin:0in 0in .0001pt;text-align:left;"><font size="2" face="Times New Roman" style="font-size:1.0pt;">&nbsp;</font></p>
  </td>
  <td width="15%" valign="top" style="padding:0in 0in 0in 0in;width:15.66%;">
  <p align="center" style="letter-spacing:.25pt;margin:0in 0in .0001pt;text-align:center;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">March 7, 2006</font></p>
  </td>
 </tr>
 <tr>
  <td width="30%" colspan="2" valign="top" style="padding:0in 0in 0in 0in;width:30.78%;">
  <p align="left" style="letter-spacing:.25pt;margin:0in 0in .0001pt;text-align:left;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">Michael B. Wood</font></p>
  </td>
  <td width="2%" valign="top" style="padding:0in 0in 0in 0in;width:2.02%;">
  <p align="left" style="letter-spacing:.25pt;margin:0in 0in .0001pt;text-align:left;"><font size="2" face="Times New Roman" style="font-size:1.0pt;">&nbsp;</font></p>
  </td>
  <td width="49%" valign="top" style="padding:0in 0in 0in 0in;width:49.54%;">
  <p align="left" style="letter-spacing:.25pt;margin:0in 0in .0001pt;text-align:left;"><font size="2" face="Times New Roman" style="font-size:1.0pt;">&nbsp;</font></p>
  </td>
  <td width="2%" valign="top" style="padding:0in 0in 0in 0in;width:2.0%;">
  <p align="left" style="letter-spacing:.25pt;margin:0in 0in .0001pt;text-align:left;"><font size="2" face="Times New Roman" style="font-size:1.0pt;">&nbsp;</font></p>
  </td>
  <td width="15%" valign="top" style="padding:0in 0in 0in 0in;width:15.66%;">
  <p align="center" style="letter-spacing:.25pt;margin:0in 0in .0001pt;text-align:center;"><font size="2" face="Times New Roman" style="font-size:1.0pt;">&nbsp;</font></p>
  </td>
 </tr>
</table>

<p align="center" style="letter-spacing:.25pt;margin:0in 0in .0001pt;text-align:center;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>

<p align="center" style="letter-spacing:.25pt;margin:0in 0in .0001pt;text-align:center;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>

<p align="center" style="letter-spacing:.25pt;margin:0in 0in .0001pt;text-align:center;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">6</font></p>

<div align="left" style="letter-spacing:.25pt;margin:0in 0in .0001pt;text-align:left;"><hr size="2" width="100%" noshade color="gray" align="left"></div>

</div>
<!-- SEQ.=1,FOLIO='6',FILE='C:\JMS\jvangc\06-6429-1\task883451\6429-1-ba.htm',USER='jvangb',CD='Mar  7 03:40 2006' -->


<br clear="all" style="page-break-before:always;">


<div style="font-family:Times New Roman;">

<p align="center" style="letter-spacing:.25pt;margin:0in 0in .0001pt;text-align:center;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>

<p align="center" style="letter-spacing:.25pt;margin:0in 0in .0001pt;text-align:center;"><b><font size="2" face="Times New Roman" style="font-size:10.0pt;font-weight:bold;letter-spacing:0pt;">INDEX TO
EXHIBITS</font></b></p>

<p align="center" style="letter-spacing:.25pt;margin:0in 0in .0001pt;text-align:center;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>

<table border="0" cellspacing="0" cellpadding="0" width="100%" style="border-collapse:collapse;width:100.0%;">
 <tr>
  <td width="6%" valign="top" style="border:none;border-bottom:solid windowtext 1.0pt;padding:0in 0in 0in 0in;width:6.26%;">
  <p align="left" style="letter-spacing:.25pt;margin:0in 0in .0001pt;text-align:left;"><b><font size="1" face="Times New Roman" style="font-size:8.0pt;font-weight:bold;letter-spacing:0pt;">Exhibit<br>
  Number</font></b></p>
  </td>
  <td width="2%" valign="bottom" style="padding:0in 0in 0in 0in;width:2.5%;">
  <p align="left" style="letter-spacing:.25pt;margin:0in 0in .0001pt;text-align:left;"><font size="1" face="Times New Roman" style="font-size:1.0pt;letter-spacing:0pt;">&nbsp;</font></p>
  </td>
  <td width="91%" valign="bottom" style="border:none;border-bottom:solid windowtext 1.0pt;padding:0in 0in 0in 0in;width:91.26%;">
  <p align="center" style="letter-spacing:.25pt;margin:0in 0in .0001pt;text-align:center;"><b><font size="1" face="Times New Roman" style="font-size:8.0pt;font-weight:bold;letter-spacing:0pt;">Description</font></b></p>
  </td>
 </tr>
 <tr>
  <td width="6%" valign="top" style="border:none;padding:0in 0in 0in 0in;width:6.26%;">
  <p align="left" style="letter-spacing:.25pt;margin:0in 0in .0001pt;text-align:left;"><font size="2" face="Times New Roman" style="font-size:10.0pt;letter-spacing:0pt;">&nbsp;</font></p>
  </td>
  <td width="2%" valign="bottom" style="padding:0in 0in 0in 0in;width:2.5%;">
  <p align="left" style="letter-spacing:.25pt;margin:0in 0in .0001pt;text-align:left;"><font size="2" face="Times New Roman" style="font-size:10.0pt;letter-spacing:0pt;">&nbsp;</font></p>
  </td>
  <td width="91%" valign="top" style="border:none;padding:0in 0in 0in 0in;width:91.26%;">
  <p align="left" style="letter-spacing:.25pt;margin:0in 0in .0001pt;text-align:left;"><font size="2" face="Times New Roman" style="font-size:10.0pt;letter-spacing:0pt;">&nbsp;</font></p>
  </td>
 </tr>
 <tr>
  <td width="6%" valign="top" style="padding:0in 0in 0in 0in;width:6.26%;">
  <p align="left" style="letter-spacing:.25pt;margin:0in 0in .0001pt 20.0pt;text-align:left;text-indent:-10.0pt;"><font size="2" face="Times New Roman" style="font-size:10.0pt;letter-spacing:0pt;">3.1</font></p>
  </td>
  <td width="2%" valign="bottom" style="padding:0in 0in 0in 0in;width:2.5%;">
  <p align="left" style="letter-spacing:.25pt;margin:0in 0in .0001pt;text-align:left;"><font size="2" face="Times New Roman" style="font-size:1.0pt;letter-spacing:0pt;">&nbsp;</font></p>
  </td>
  <td width="91%" valign="top" style="padding:0in 0in 0in 0in;width:91.26%;">
  <p align="left" style="letter-spacing:.25pt;margin:0in 0in .0001pt;text-align:left;"><font size="2" face="Times New Roman" style="font-size:10.0pt;letter-spacing:0pt;">Restated
  Certificate of Incorporation Cubist (incorporated by reference to Exhibit 3
  to Cubist&#146;s Quarterly Report on Form 10-Q filed on August 6, 2004) (File no.
  000-21379).</font></p>
  </td>
 </tr>
 <tr>
  <td width="6%" valign="top" style="padding:0in 0in 0in 0in;width:6.26%;">
  <p align="left" style="letter-spacing:.25pt;margin:0in 0in .0001pt 20.0pt;text-align:left;text-indent:-10.0pt;"><font size="2" face="Times New Roman" style="font-size:10.0pt;letter-spacing:0pt;">&nbsp;</font></p>
  </td>
  <td width="2%" valign="bottom" style="padding:0in 0in 0in 0in;width:2.5%;">
  <p align="left" style="letter-spacing:.25pt;margin:0in 0in .0001pt;text-align:left;"><font size="2" face="Times New Roman" style="font-size:10.0pt;letter-spacing:0pt;">&nbsp;</font></p>
  </td>
  <td width="91%" valign="top" style="padding:0in 0in 0in 0in;width:91.26%;">
  <p align="left" style="letter-spacing:.25pt;margin:0in 0in .0001pt;text-align:left;"><font size="2" face="Times New Roman" style="font-size:10.0pt;letter-spacing:0pt;">&nbsp;</font></p>
  </td>
 </tr>
 <tr>
  <td width="6%" valign="top" style="padding:0in 0in 0in 0in;width:6.26%;">
  <p align="left" style="letter-spacing:.25pt;margin:0in 0in .0001pt 20.0pt;text-align:left;text-indent:-10.0pt;"><font size="2" face="Times New Roman" style="font-size:10.0pt;letter-spacing:0pt;">3.2</font></p>
  </td>
  <td width="2%" valign="bottom" style="padding:0in 0in 0in 0in;width:2.5%;">
  <p align="left" style="letter-spacing:.25pt;margin:0in 0in .0001pt;text-align:left;"><font size="2" face="Times New Roman" style="font-size:1.0pt;letter-spacing:0pt;">&nbsp;</font></p>
  </td>
  <td width="91%" valign="top" style="padding:0in 0in 0in 0in;width:91.26%;">
  <p align="left" style="letter-spacing:.25pt;margin:0in 0in .0001pt;text-align:left;"><font size="2" face="Times New Roman" style="font-size:10.0pt;letter-spacing:0pt;">Amended
  and Restated By-Laws of Cubist, as amended to date. (incorporated by
  reference to Exhibit 3.4, Registration No. 333-06795).</font></p>
  </td>
 </tr>
 <tr>
  <td width="6%" valign="top" style="padding:0in 0in 0in 0in;width:6.26%;">
  <p align="left" style="letter-spacing:.25pt;margin:0in 0in .0001pt 20.0pt;text-align:left;text-indent:-10.0pt;"><font size="2" face="Times New Roman" style="font-size:10.0pt;letter-spacing:0pt;">&nbsp;</font></p>
  </td>
  <td width="2%" valign="bottom" style="padding:0in 0in 0in 0in;width:2.5%;">
  <p align="left" style="letter-spacing:.25pt;margin:0in 0in .0001pt;text-align:left;"><font size="2" face="Times New Roman" style="font-size:10.0pt;letter-spacing:0pt;">&nbsp;</font></p>
  </td>
  <td width="91%" valign="top" style="padding:0in 0in 0in 0in;width:91.26%;">
  <p align="left" style="letter-spacing:.25pt;margin:0in 0in .0001pt;text-align:left;"><font size="2" face="Times New Roman" style="font-size:10.0pt;letter-spacing:0pt;">&nbsp;</font></p>
  </td>
 </tr>
 <tr>
  <td width="6%" valign="top" style="padding:0in 0in 0in 0in;width:6.26%;">
  <p align="left" style="letter-spacing:.25pt;margin:0in 0in .0001pt 20.0pt;text-align:left;text-indent:-10.0pt;"><font size="2" face="Times New Roman" style="font-size:10.0pt;letter-spacing:0pt;">4.1</font></p>
  </td>
  <td width="2%" valign="bottom" style="padding:0in 0in 0in 0in;width:2.5%;">
  <p align="left" style="letter-spacing:.25pt;margin:0in 0in .0001pt;text-align:left;"><font size="2" face="Times New Roman" style="font-size:1.0pt;letter-spacing:0pt;">&nbsp;</font></p>
  </td>
  <td width="91%" valign="top" style="padding:0in 0in 0in 0in;width:91.26%;">
  <p align="left" style="letter-spacing:.25pt;margin:0in 0in .0001pt;text-align:left;"><font size="2" face="Times New Roman" style="font-size:10.0pt;letter-spacing:0pt;">Specimen
  certificate for shares of Common Stock (incorporated by reference to Exhibit
  4.1 to Cubist&#146;s Annual Report on Form 10-K filed on March 1, 2006)
  (Registration No. 000-21379).</font></p>
  </td>
 </tr>
 <tr>
  <td width="6%" valign="top" style="padding:0in 0in 0in 0in;width:6.26%;">
  <p align="left" style="letter-spacing:.25pt;margin:0in 0in .0001pt 20.0pt;text-align:left;text-indent:-10.0pt;"><font size="2" face="Times New Roman" style="font-size:10.0pt;letter-spacing:0pt;">&nbsp;</font></p>
  </td>
  <td width="2%" valign="bottom" style="padding:0in 0in 0in 0in;width:2.5%;">
  <p align="left" style="letter-spacing:.25pt;margin:0in 0in .0001pt;text-align:left;"><font size="2" face="Times New Roman" style="font-size:10.0pt;letter-spacing:0pt;">&nbsp;</font></p>
  </td>
  <td width="91%" valign="top" style="padding:0in 0in 0in 0in;width:91.26%;">
  <p align="left" style="letter-spacing:.25pt;margin:0in 0in .0001pt;text-align:left;"><font size="2" face="Times New Roman" style="font-size:10.0pt;letter-spacing:0pt;">&nbsp;</font></p>
  </td>
 </tr>
 <tr>
  <td width="6%" valign="top" style="padding:0in 0in 0in 0in;width:6.26%;">
  <p align="left" style="letter-spacing:.25pt;margin:0in 0in .0001pt 20.0pt;text-align:left;text-indent:-10.0pt;"><font size="2" face="Times New Roman" style="font-size:10.0pt;letter-spacing:0pt;">4.2</font></p>
  </td>
  <td width="2%" valign="bottom" style="padding:0in 0in 0in 0in;width:2.5%;">
  <p align="left" style="letter-spacing:.25pt;margin:0in 0in .0001pt;text-align:left;"><font size="2" face="Times New Roman" style="font-size:1.0pt;letter-spacing:0pt;">&nbsp;</font></p>
  </td>
  <td width="91%" valign="top" style="padding:0in 0in 0in 0in;width:91.26%;">
  <p align="left" style="font-size:10.0pt;letter-spacing:.25pt;margin:0in 0in .0001pt;text-align:left;"><font size="2" face="Times New Roman"><font style="font-size:10.0pt;letter-spacing:0pt;">Rights
  Agreement dated as of July 21, 1999 between Cubist and Computershare Trust
  Company N.A. (f/k/a </font>EquiServe Trust Company, N.A. f/k/a Fleet National
  Bank f/k/a BankBoston, N.A.), </font><font style="letter-spacing:0pt;">as
  Rights Agent (incorporated herein by reference to Exhibit 4.1 to the
  Company&#146;s Registration Statement on Form 8-A/A filed on August 5, 2005) (File
  No. 000-21379).</font></p>
  </td>
 </tr>
 <tr>
  <td width="6%" valign="top" style="padding:0in 0in 0in 0in;width:6.26%;">
  <p align="left" style="letter-spacing:.25pt;margin:0in 0in .0001pt 20.0pt;text-align:left;text-indent:-10.0pt;"><font size="2" face="Times New Roman" style="font-size:10.0pt;letter-spacing:0pt;">&nbsp;</font></p>
  </td>
  <td width="2%" valign="bottom" style="padding:0in 0in 0in 0in;width:2.5%;">
  <p align="left" style="letter-spacing:.25pt;margin:0in 0in .0001pt;text-align:left;"><font size="2" face="Times New Roman" style="font-size:10.0pt;letter-spacing:0pt;">&nbsp;</font></p>
  </td>
  <td width="91%" valign="top" style="padding:0in 0in 0in 0in;width:91.26%;">
  <p align="left" style="letter-spacing:.25pt;margin:0in 0in .0001pt;text-align:left;"><font size="2" face="Times New Roman" style="font-size:10.0pt;letter-spacing:0pt;">&nbsp;</font></p>
  </td>
 </tr>
 <tr>
  <td width="6%" valign="top" style="padding:0in 0in 0in 0in;width:6.26%;">
  <p align="left" style="letter-spacing:.25pt;margin:0in 0in .0001pt 20.0pt;text-align:left;text-indent:-10.0pt;"><font size="2" face="Times New Roman" style="font-size:10.0pt;letter-spacing:0pt;">4.3</font></p>
  </td>
  <td width="2%" valign="bottom" style="padding:0in 0in 0in 0in;width:2.5%;">
  <p align="left" style="letter-spacing:.25pt;margin:0in 0in .0001pt;text-align:left;"><font size="2" face="Times New Roman" style="font-size:1.0pt;letter-spacing:0pt;">&nbsp;</font></p>
  </td>
  <td width="91%" valign="top" style="padding:0in 0in 0in 0in;width:91.26%;">
  <p align="left" style="font-size:10.0pt;letter-spacing:.25pt;margin:0in 0in .0001pt;text-align:left;"><font size="2" face="Times New Roman"><font style="font-size:10.0pt;letter-spacing:0pt;">First
  Amendment, dated as of March 7, 2000, to the Rights Agreement, dated as of
  July 21, 1999 between the Company and Computershare Trust Company N.A. (f/k/a
  </font>EquiServe Trust Company, N.A. f/k/a Fleet National Bank f/k/a
  BankBoston, N.A.)</font><font style="letter-spacing:0pt;">, as Rights Agent
  (incorporated herein by reference to Exhibit 4.2 to the Company&#146;s
  Registration Statement on Form 8-A/A filed on August 5, 2005) (File No.
  000-21379).</font></p>
  </td>
 </tr>
 <tr>
  <td width="6%" valign="top" style="padding:0in 0in 0in 0in;width:6.26%;">
  <p align="left" style="letter-spacing:.25pt;margin:0in 0in .0001pt 20.0pt;text-align:left;text-indent:-10.0pt;"><font size="2" face="Times New Roman" style="font-size:10.0pt;letter-spacing:0pt;">&nbsp;</font></p>
  </td>
  <td width="2%" valign="bottom" style="padding:0in 0in 0in 0in;width:2.5%;">
  <p align="left" style="letter-spacing:.25pt;margin:0in 0in .0001pt;text-align:left;"><font size="2" face="Times New Roman" style="font-size:10.0pt;letter-spacing:0pt;">&nbsp;</font></p>
  </td>
  <td width="91%" valign="top" style="padding:0in 0in 0in 0in;width:91.26%;">
  <p align="left" style="letter-spacing:.25pt;margin:0in 0in .0001pt;text-align:left;"><font size="2" face="Times New Roman" style="font-size:10.0pt;letter-spacing:0pt;">&nbsp;</font></p>
  </td>
 </tr>
 <tr>
  <td width="6%" valign="top" style="padding:0in 0in 0in 0in;width:6.26%;">
  <p align="left" style="letter-spacing:.25pt;margin:0in 0in .0001pt 20.0pt;text-align:left;text-indent:-10.0pt;"><font size="2" face="Times New Roman" style="font-size:10.0pt;letter-spacing:0pt;">4.4</font></p>
  </td>
  <td width="2%" valign="bottom" style="padding:0in 0in 0in 0in;width:2.5%;">
  <p align="left" style="letter-spacing:.25pt;margin:0in 0in .0001pt;text-align:left;"><font size="2" face="Times New Roman" style="font-size:1.0pt;letter-spacing:0pt;">&nbsp;</font></p>
  </td>
  <td width="91%" valign="top" style="padding:0in 0in 0in 0in;width:91.26%;">
  <p align="left" style="font-size:10.0pt;letter-spacing:.25pt;margin:0in 0in .0001pt;text-align:left;"><font size="2" face="Times New Roman"><font style="font-size:10.0pt;letter-spacing:0pt;">Amendment,
  dated as of March 20, 2002, to the Rights Agreement, dated as of July 21,
  1999 between the Company and Computershare Trust Company N.A. (f/k/a </font>EquiServe
  Trust Company, N.A. f/k/a Fleet National Bank f/k/a BankBoston, N.A.)</font><font style="letter-spacing:0pt;">, as Rights Agent (incorporated herein by reference
  to Exhibit 4.3 to the Company&#146;s Registration Statement on Form 8-A/A filed on
  August 5, 2005) (File No. 000-21379).</font></p>
  </td>
 </tr>
 <tr>
  <td width="6%" valign="top" style="padding:0in 0in 0in 0in;width:6.26%;">
  <p align="left" style="letter-spacing:.25pt;margin:0in 0in .0001pt 20.0pt;text-align:left;text-indent:-10.0pt;"><font size="2" face="Times New Roman" style="font-size:10.0pt;letter-spacing:0pt;">&nbsp;</font></p>
  </td>
  <td width="2%" valign="bottom" style="padding:0in 0in 0in 0in;width:2.5%;">
  <p align="left" style="letter-spacing:.25pt;margin:0in 0in .0001pt;text-align:left;"><font size="2" face="Times New Roman" style="font-size:10.0pt;letter-spacing:0pt;">&nbsp;</font></p>
  </td>
  <td width="91%" valign="top" style="padding:0in 0in 0in 0in;width:91.26%;">
  <p align="left" style="letter-spacing:.25pt;margin:0in 0in .0001pt;text-align:left;"><font size="2" face="Times New Roman" style="font-size:10.0pt;letter-spacing:0pt;">&nbsp;</font></p>
  </td>
 </tr>
 <tr>
  <td width="6%" valign="top" style="padding:0in 0in 0in 0in;width:6.26%;">
  <p align="left" style="letter-spacing:.25pt;margin:0in 0in .0001pt 20.0pt;text-align:left;text-indent:-10.0pt;"><font size="2" face="Times New Roman" style="font-size:10.0pt;letter-spacing:0pt;">4.5</font></p>
  </td>
  <td width="2%" valign="bottom" style="padding:0in 0in 0in 0in;width:2.5%;">
  <p align="left" style="letter-spacing:.25pt;margin:0in 0in .0001pt;text-align:left;"><font size="2" face="Times New Roman" style="font-size:1.0pt;letter-spacing:0pt;">&nbsp;</font></p>
  </td>
  <td width="91%" valign="top" style="padding:0in 0in 0in 0in;width:91.26%;">
  <p align="left" style="font-size:10.0pt;letter-spacing:.25pt;margin:0in 0in .0001pt;text-align:left;"><font size="2" face="Times New Roman"><font style="font-size:10.0pt;letter-spacing:0pt;">Third
  Amendment, dated as of August 2, 2005, to the Rights Agreement, dated as of
  July 21, 1999 between the Company and Computershare Trust Company N.A. (f/k/a
  </font>EquiServe Trust Company, N.A. f/k/a Fleet National Bank f/k/a
  BankBoston, N.A.)</font><font style="letter-spacing:0pt;">, as Rights Agent
  (incorporated herein by reference to Exhibit 4.4 to the Company&#146;s
  Registration Statement on Form 8-A/A filed on August 5, 2005) (File No.
  000-21379).</font></p>
  </td>
 </tr>
 <tr>
  <td width="6%" valign="top" style="padding:0in 0in 0in 0in;width:6.26%;">
  <p align="left" style="letter-spacing:.25pt;margin:0in 0in .0001pt 20.0pt;text-align:left;text-indent:-10.0pt;"><font size="2" face="Times New Roman" style="font-size:10.0pt;letter-spacing:0pt;">&nbsp;</font></p>
  </td>
  <td width="2%" valign="bottom" style="padding:0in 0in 0in 0in;width:2.5%;">
  <p align="left" style="letter-spacing:.25pt;margin:0in 0in .0001pt;text-align:left;"><font size="2" face="Times New Roman" style="font-size:10.0pt;letter-spacing:0pt;">&nbsp;</font></p>
  </td>
  <td width="91%" valign="top" style="padding:0in 0in 0in 0in;width:91.26%;">
  <p align="left" style="letter-spacing:.25pt;margin:0in 0in .0001pt;text-align:left;"><font size="2" face="Times New Roman" style="font-size:10.0pt;letter-spacing:0pt;">&nbsp;</font></p>
  </td>
 </tr>
 <tr>
  <td width="6%" valign="top" style="padding:0in 0in 0in 0in;width:6.26%;">
  <p align="left" style="letter-spacing:.25pt;margin:0in 0in .0001pt 20.0pt;text-align:left;text-indent:-10.0pt;"><font size="2" face="Times New Roman" style="font-size:10.0pt;letter-spacing:0pt;">4.6</font></p>
  </td>
  <td width="2%" valign="bottom" style="padding:0in 0in 0in 0in;width:2.5%;">
  <p align="left" style="letter-spacing:.25pt;margin:0in 0in .0001pt;text-align:left;"><font size="2" face="Times New Roman" style="font-size:1.0pt;letter-spacing:0pt;">&nbsp;</font></p>
  </td>
  <td width="91%" valign="top" style="padding:0in 0in 0in 0in;width:91.26%;">
  <p align="left" style="letter-spacing:.25pt;margin:0in 0in .0001pt;text-align:left;"><font size="2" face="Times New Roman" style="font-size:10.0pt;letter-spacing:0pt;">Form
  of Amended Rights Certificate (incorporated herein by reference to Exhibit
  4.4 to the Company&#146;s Registration Statement on Form 8-A/A filed on March 9,
  2000) (File No. 000-21379).</font></p>
  </td>
 </tr>
 <tr>
  <td width="6%" valign="top" style="padding:0in 0in 0in 0in;width:6.26%;">
  <p align="left" style="letter-spacing:.25pt;margin:0in 0in .0001pt 20.0pt;text-align:left;text-indent:-10.0pt;"><font size="2" face="Times New Roman" style="font-size:10.0pt;letter-spacing:0pt;">&nbsp;</font></p>
  </td>
  <td width="2%" valign="bottom" style="padding:0in 0in 0in 0in;width:2.5%;">
  <p align="left" style="letter-spacing:.25pt;margin:0in 0in .0001pt;text-align:left;"><font size="2" face="Times New Roman" style="font-size:10.0pt;letter-spacing:0pt;">&nbsp;</font></p>
  </td>
  <td width="91%" valign="top" style="padding:0in 0in 0in 0in;width:91.26%;">
  <p align="left" style="letter-spacing:.25pt;margin:0in 0in .0001pt;text-align:left;"><font size="2" face="Times New Roman" style="font-size:10.0pt;letter-spacing:0pt;">&nbsp;</font></p>
  </td>
 </tr>
 <tr>
  <td width="6%" valign="top" style="padding:0in 0in 0in 0in;width:6.26%;">
  <p align="left" style="letter-spacing:.25pt;margin:0in 0in .0001pt 20.0pt;text-align:left;text-indent:-10.0pt;"><font size="2" face="Times New Roman" style="font-size:10.0pt;letter-spacing:0pt;">5</font></p>
  </td>
  <td width="2%" valign="bottom" style="padding:0in 0in 0in 0in;width:2.5%;">
  <p align="left" style="letter-spacing:.25pt;margin:0in 0in .0001pt;text-align:left;"><font size="2" face="Times New Roman" style="font-size:1.0pt;letter-spacing:0pt;">&nbsp;</font></p>
  </td>
  <td width="91%" valign="top" style="padding:0in 0in 0in 0in;width:91.26%;">
  <p align="left" style="letter-spacing:.25pt;margin:0in 0in .0001pt;text-align:left;"><font size="2" face="Times New Roman" style="font-size:10.0pt;letter-spacing:0pt;">Opinion
  of Bingham McCutchen LLP with respect to the legality of the shares being
  registered.</font></p>
  </td>
 </tr>
 <tr>
  <td width="6%" valign="top" style="padding:0in 0in 0in 0in;width:6.26%;">
  <p align="left" style="letter-spacing:.25pt;margin:0in 0in .0001pt 20.0pt;text-align:left;text-indent:-10.0pt;"><font size="2" face="Times New Roman" style="font-size:10.0pt;letter-spacing:0pt;">&nbsp;</font></p>
  </td>
  <td width="2%" valign="bottom" style="padding:0in 0in 0in 0in;width:2.5%;">
  <p align="left" style="letter-spacing:.25pt;margin:0in 0in .0001pt;text-align:left;"><font size="2" face="Times New Roman" style="font-size:10.0pt;letter-spacing:0pt;">&nbsp;</font></p>
  </td>
  <td width="91%" valign="top" style="padding:0in 0in 0in 0in;width:91.26%;">
  <p align="left" style="letter-spacing:.25pt;margin:0in 0in .0001pt;text-align:left;"><font size="2" face="Times New Roman" style="font-size:10.0pt;letter-spacing:0pt;">&nbsp;</font></p>
  </td>
 </tr>
 <tr>
  <td width="6%" valign="top" style="padding:0in 0in 0in 0in;width:6.26%;">
  <p align="left" style="letter-spacing:.25pt;margin:0in 0in .0001pt 20.0pt;text-align:left;text-indent:-10.0pt;"><font size="2" face="Times New Roman" style="font-size:10.0pt;letter-spacing:0pt;">23.1</font></p>
  </td>
  <td width="2%" valign="bottom" style="padding:0in 0in 0in 0in;width:2.5%;">
  <p align="left" style="letter-spacing:.25pt;margin:0in 0in .0001pt;text-align:left;"><font size="2" face="Times New Roman" style="font-size:1.0pt;letter-spacing:0pt;">&nbsp;</font></p>
  </td>
  <td width="91%" valign="top" style="padding:0in 0in 0in 0in;width:91.26%;">
  <p align="left" style="letter-spacing:.25pt;margin:0in 0in .0001pt;text-align:left;"><font size="2" face="Times New Roman" style="font-size:10.0pt;letter-spacing:0pt;">Consent
  of Bingham McCutchen LLP (included in Exhibit 5).</font></p>
  </td>
 </tr>
 <tr>
  <td width="6%" valign="top" style="padding:0in 0in 0in 0in;width:6.26%;">
  <p align="left" style="letter-spacing:.25pt;margin:0in 0in .0001pt 20.0pt;text-align:left;text-indent:-10.0pt;"><font size="2" face="Times New Roman" style="font-size:10.0pt;letter-spacing:0pt;">&nbsp;</font></p>
  </td>
  <td width="2%" valign="bottom" style="padding:0in 0in 0in 0in;width:2.5%;">
  <p align="left" style="letter-spacing:.25pt;margin:0in 0in .0001pt;text-align:left;"><font size="2" face="Times New Roman" style="font-size:10.0pt;letter-spacing:0pt;">&nbsp;</font></p>
  </td>
  <td width="91%" valign="top" style="padding:0in 0in 0in 0in;width:91.26%;">
  <p align="left" style="letter-spacing:.25pt;margin:0in 0in .0001pt;text-align:left;"><font size="2" face="Times New Roman" style="font-size:10.0pt;letter-spacing:0pt;">&nbsp;</font></p>
  </td>
 </tr>
 <tr>
  <td width="6%" valign="top" style="padding:0in 0in 0in 0in;width:6.26%;">
  <p align="left" style="letter-spacing:.25pt;margin:0in 0in .0001pt 20.0pt;text-align:left;text-indent:-10.0pt;"><font size="2" face="Times New Roman" style="font-size:10.0pt;letter-spacing:0pt;">23.2</font></p>
  </td>
  <td width="2%" valign="bottom" style="padding:0in 0in 0in 0in;width:2.5%;">
  <p align="left" style="letter-spacing:.25pt;margin:0in 0in .0001pt;text-align:left;"><font size="2" face="Times New Roman" style="font-size:1.0pt;letter-spacing:0pt;">&nbsp;</font></p>
  </td>
  <td width="91%" valign="top" style="padding:0in 0in 0in 0in;width:91.26%;">
  <p align="left" style="font-size:10.0pt;letter-spacing:.25pt;margin:0in 0in .0001pt;text-align:left;"><font size="2" face="Times New Roman"><font style="font-size:10.0pt;letter-spacing:0pt;">Consent
  of </font>Independent Registered Public Accounting Firm</font><font style="letter-spacing:0pt;">.</font></p>
  </td>
 </tr>
 <tr>
  <td width="6%" valign="top" style="padding:0in 0in 0in 0in;width:6.26%;">
  <p align="left" style="letter-spacing:.25pt;margin:0in 0in .0001pt 20.0pt;text-align:left;text-indent:-10.0pt;"><font size="2" face="Times New Roman" style="font-size:10.0pt;letter-spacing:0pt;">&nbsp;</font></p>
  </td>
  <td width="2%" valign="bottom" style="padding:0in 0in 0in 0in;width:2.5%;">
  <p align="left" style="letter-spacing:.25pt;margin:0in 0in .0001pt;text-align:left;"><font size="2" face="Times New Roman" style="font-size:10.0pt;letter-spacing:0pt;">&nbsp;</font></p>
  </td>
  <td width="91%" valign="top" style="padding:0in 0in 0in 0in;width:91.26%;">
  <p align="left" style="letter-spacing:.25pt;margin:0in 0in .0001pt;text-align:left;"><font size="2" face="Times New Roman" style="font-size:10.0pt;letter-spacing:0pt;">&nbsp;</font></p>
  </td>
 </tr>
 <tr>
  <td width="6%" valign="top" style="padding:0in 0in 0in 0in;width:6.26%;">
  <p align="left" style="letter-spacing:.25pt;margin:0in 0in .0001pt 20.0pt;text-align:left;text-indent:-10.0pt;"><font size="2" face="Times New Roman" style="font-size:10.0pt;letter-spacing:0pt;">24</font></p>
  </td>
  <td width="2%" valign="bottom" style="padding:0in 0in 0in 0in;width:2.5%;">
  <p align="left" style="letter-spacing:.25pt;margin:0in 0in .0001pt;text-align:left;"><font size="2" face="Times New Roman" style="font-size:1.0pt;letter-spacing:0pt;">&nbsp;</font></p>
  </td>
  <td width="91%" valign="top" style="padding:0in 0in 0in 0in;width:91.26%;">
  <p align="left" style="letter-spacing:.25pt;margin:0in 0in .0001pt;text-align:left;"><font size="2" face="Times New Roman" style="font-size:10.0pt;letter-spacing:0pt;">Power
  of Attorney (included in signature page to registration statement).</font></p>
  </td>
 </tr>
 <tr>
  <td width="6%" valign="top" style="padding:0in 0in 0in 0in;width:6.26%;">
  <p align="left" style="letter-spacing:.25pt;margin:0in 0in .0001pt 20.0pt;text-align:left;text-indent:-10.0pt;"><font size="2" face="Times New Roman" style="font-size:10.0pt;letter-spacing:0pt;">&nbsp;</font></p>
  </td>
  <td width="2%" valign="bottom" style="padding:0in 0in 0in 0in;width:2.5%;">
  <p align="left" style="letter-spacing:.25pt;margin:0in 0in .0001pt;text-align:left;"><font size="2" face="Times New Roman" style="font-size:10.0pt;letter-spacing:0pt;">&nbsp;</font></p>
  </td>
  <td width="91%" valign="top" style="padding:0in 0in 0in 0in;width:91.26%;">
  <p align="left" style="letter-spacing:.25pt;margin:0in 0in .0001pt;text-align:left;"><font size="2" face="Times New Roman" style="font-size:10.0pt;letter-spacing:0pt;">&nbsp;</font></p>
  </td>
 </tr>
</table>

<p align="center" style="letter-spacing:.25pt;margin:0in 0in .0001pt;text-align:center;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>

<p align="center" style="letter-spacing:.25pt;margin:0in 0in .0001pt;text-align:center;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">7</font></p>

<div align="left" style="letter-spacing:.25pt;margin:0in 0in .0001pt;text-align:left;"><hr size="2" width="100%" noshade color="gray" align="left"></div>

</div>
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[{"type": "S-8", "sequence": "1", "filename": "a06-6429_1s8.htm", "description": "SECURITIES TO BE OFFERED TO EMPLOYEES PURSUANT TO EMPLOYEE BENEFIT PLANS", "secsgml_size_bytes": 143107}]
{"company-data": {"conformed-name": "CUBIST PHARMACEUTICALS INC", "cik": "0000912183", "assigned-sic": "2834", "irs-number": "223192085", "state-of-incorporation": "DE", "fiscal-year-end": "1231"}, "filing-values": {"form-type": "S-8", "act": "33", "file-number": "333-132248", "film-number": "06669709"}, "business-address": {"street1": "65 HAYDEN AVENUE", "city": "LEXINGTON", "state": "MA", "zip": "02421", "phone": "781-860-8660"}, "mail-address": {"street1": "24 EMILY ST", "city": "CAMBRIDGE", "state": "MA", "zip": "02139"}}
As filed with the Securities and
Exchange Commission on March 7, 2006
File No. 333-
UNITED STATES
SECURITIES AND EXCHANGE
COMMISSION
WASHINGTON, DC 20549
FORM S-8
REGISTRATION
STATEMENT
UNDER
THE SECURITIES ACT OF 1933
CUBIST PHARMACEUTICALS, INC.
(Exact Name of Registrant
as Specified in Its Charter)
DELAWARE
22-3192085
(State
  or Other Jurisdiction of Incorporation or Organization)
(I.R.S.
  Employer Identification No.)
65 Hayden
Avenue, Lexington, MA 02421
(Address
of Principal Executive Offices) (Zip Code)
CUBIST
PHARMACEUTICALS, INC.
AMENDED AND
RESTATED 2000 EQUITY INCENTIVE PLAN
(Full
Title of the Plan)
Michael W.
Bonney
President and
Chief Executive Officer
CUBIST PHARMACEUTICALS, INC.
65 Hayden
Avenue
Lexington,
Massachusetts 02421
(Name
and Address of Agent For Service)
(781) 860-8660
Telephone
Number, Including Area Code, of Agent for Service
Copies to:
Julio E. Vega,
Esq
.
Matthew J.
Cushing, Esq.
BINGHAM MCCUTCHEN LLP
150 Federal
Street
Boston, MA
02110-1726
(617) 951-8000
CALCULATION OF
REGISTRATION FEE
Title
  Of
Securities To Be Registered
Amount
To Be
Registered
Proposed Maximum
Offering Price
Per Share
Proposed Maximum
Aggregate
Offering Price
(1)
Amount Of
Registration
Fee
Common Stock, $0.001
  par value
3,046,436
$
22.60
(1)
$
68,849,453
$
7,366.89
(1)           The proposed maximum offering price
has been estimated pursuant to Rule 457(h) solely for the purpose of
calculating the registration fee.  It is
not known how many of these shares will be purchased or at what price.  The estimate of the proposed maximum
aggregate offering price has been calculated based on the offering of all
3,046,436
shares registered hereunder
pursuant to the grant of stock options under the
Amended and Restated 2000 Equity Incentive Plan
exercisable for all of such shares, at an exercise price of $22.60 per share,
which is the average of the high and low prices of Cubist's common stock as
listed on the National Association of Securities Dealers Automated Quotation
National Market System on February 28, 2006.
Pursuant to Rule 429 promulgated under the Securities Act of 1933, as
amended, the prospectus relating to this Registration Statement is a combined
prospectus that relates also to the Registration Statement on Form S-8 (File
No. 333-124210) previously filed by the registrant on April 21, 2005, which
registers
2,900,000 shares
of common stock,
the Registration
Statement on Form S-8 (File No. 333-118065) previously filed by the registrant
on August 10, 2004, which registers
3,866,564 shares of common stock,
the Registration Statement on Form S-8 (File No. 333-106388) previously
filed by the registrant on June 23, 2003, which registers 60,000 shares of
common stock, Registration Statement on Form S-8 (File No. 333-99739)
previously filed by the registrant on September 18, 2002, which registers
1,927,067 shares of common stock, Registration Statement on Form S-8 (File No.
333-60168) previously filed by the registrant on May 3, 2001, which registers
1,500,000 shares of common stock, Registration Statement on Form S-8
(File No. 333-60152)
previously filed by the registrant on May 3, 2001, which registers 1,080,359
shares of common stock, Registration Statement on Form S-8 (File No. 333-49522)
previously filed by the registrant on November 8, 2000, which registers
1,000,000 shares of common stock, Registration Statement on Form S-8 (File No.
333-32178) previously filed by the registrant on March 10, 2000, which
registers 844,573 shares of common stock, the Registration Statement on Form
S-8 (File No. 333-65385) previously filed by the registrant on October 6, 1998,
which registers 655,427 shares of common stock, and the Registration Statement
on Form S-8 (File No. 33-25707) previously filed by the registrant on April 23,
1997, which registers 1,500,000 shares of common stock. An aggregate filing fee
for all such prior registration statements in the amount of $53,286.12 was
previously paid with respect to such shares.
EXPLANATORY
NOTE
On April 23, 1997, we filed a Registration Statement on Form S-8 (File No. 333-25707) (referred to in this document as, the "First Registration Statement") to register under the Securities Act of 1933, as amended, or, the Securities Act, 1,500,000 shares of common stock, par value $0.001 per share, issuable by us under the Amended and Restated 1993 Stock Option Plan, or, the 1993 Plan. On October 6, 1998, we filed a Registration Statement on Form S-8 (File No. 333-65385) (referred to in this document as the "Second Registration Statement") to register under the Securities Act an additional 655,427 shares of our common stock issuable by us under the 1993 Plan. On March 10, 2000, we filed a Registration Statement on Form S-8 (File No. 333-32178) (referred to in this document as the "Third Registration Statement") to register under the Securities Act an additional 844,573 shares of our common stock issuable by us under the 1993 Plan. On November 8, 2000, we filed a Registration Statement on Form S-8 (File No. 333-49522) (referred to in this document as the "Fourth Registration Statement") to register under the Securities Act an additional 1,000,000 shares of our common stock issuable by us under the 1993 Plan. On May 3, 2001 we filed a Registration Statement on Form S-8 (File No. 333- 60168) (referred to in this document as the "Fifth Registration Statement") to register under the Securities Act an additional 1,000,000 shares of our common stock issuable by us under the Amended and Restated 2000 Equity Incentive Plan (formerly the 2000 Nonstatutory Stock Option Plan), or, the 2000 Equity Incentive Plan and 500,000 shares of our comment stock issuable by us under the 2001 UK Stock Option Plan, or, the 2001 Plan. On May 3, 2001 we also filed a Registration Statement on Form S-8 (File No. 333-60152) (referred to in this document as the "Sixth Registration Statement") to register under the Securities Act an additional 1,080,359 shares of our common stock issuable by us under the 1993 Plan. On September 18, 2002 we filed a Registration Statement on  Form S-8 (File No. 333- 99739) (referred to in this document as the "Seventh Registration Statement") to register under the Securities Act an additional 697,067 shares of our common stock issuable by us under the 1993 Plan, 1,055,000 shares issuable by us under the 2000 Equity Incentive Plan and 175,000 shares
issuable by us under the 2002 Directors' Stock Option Plan
.  On June 23, 2003 we filed a Registration Statement on Form S-8 (File No. 333-106388) (referred to in this document as the "Eighth Registration Statement") to register under the Securities Act an additional 60,000 shares of our common stock issuable by us under the 1993 Plan.  On August 10, 2004, we filed a Registration Statement on Form S-8 (File No. 333-118065) (referred to in this document as the "Ninth Registration Statement") to register under the Securities Act an additional
3,516,564 shares of common stock issuable by us under the 2000 Equity Incentive Plan and 350,000 shares issuable by us under the 2002 Directors' Stock Option Plan.
On April 21, 2005, we filed a Registration Statement on Form S-8 (File No. 333-124210) (referred to in this document as the "Tenth Registration Statement") to register under the Securities Act an additional
2,900,000 shares of common stock issuable by us under the 2000 Equity Incentive Plan.
By the terms of the 2000 Equity Incentive Plan, since the time of the filing of the Tenth Registration Statement, the aggregate number of shares of our common stock subject to issuance under the 2000 Equity Incentive Plan automatically increased by 3,046,436 as of January 1, 2006.
This Registration Statement on Form S-8 has been prepared and filed pursuant to and in accordance with the requirements of General Instruction E to Form S-8 for the purpose of effecting the registration under the Securities Act of the additional 3,046,436 shares of our common stock subject to issuance upon exercise of stock options that may be granted under the 2000 Equity Incentive Plan at any time or from time to time after the date hereof under such plan. Pursuant to General Instruction E to Form S-8, the registrant hereby incorporates herein by reference the contents of the First Registration Statement, Second Registration Statement, Third Registration Statement, Fourth Registration Statement, Fifth Registration Statement, Sixth Registration Statement, Seventh Registration Statement, Eighth Registration Statement, Ninth Registration Statement and Tenth Registration Statement.
2
PART II
INFORMATION
REQUIRED IN THE REGISTRATION STATEMENT
Item 3.
Incorporation of Documents
by Reference.
We incorporate by reference the documents listed below and any future
filings we will make with the SEC under Section 13(a), 13(c), 14
or 15(d) of the Securities Exchange Act of 1934, as amended:
•
Annual Report on Form 10-K for the year ended
December 31, 2005;
•
Current
Reports on Form 8-K filed with the SEC on January 27, 2006 and February 1,
2006;
•
the description of our common stock contained in our
registration statement on Form 8-A filed with the SEC on September 17, 1996,
including any amendments or reports filed for the purpose of updating that
description; and
•
the description of the preferred stock purchase
rights for our Series A Junior Participating Preferred Stock contained in our
registration statement on Form 8-A filed with the SEC on August 2, 1999,
including any amendments or reports filed for the purpose of updating that
description.
You
may request a copy of these filings at no cost (other than exhibits unless those
exhibits are specifically incorporated by reference herein) by writing,
telephoning or e-mailing us at the following address:
Cubist Pharmaceuticals, Inc.
65 Hayden Avenue
Lexington, MA 02421
Attn: Investor Relations
(781) 860-8660
e-mail: ir@cubist.com
Item 4.
Description of Securities
Not applicable.
Item 5.
Interests of Named Experts
or Counsel
Not applicable.
Item 6.
Indemnification of
Directors and Officers
Section 145 of the Delaware General Corporation Law empowers a Delaware
corporation to indemnify its officers and directors and certain other persons
to the extent and under the circumstances set forth therein.
The Restated Certificate of Incorporation and the Amended and Restated
By-Laws of Cubist, copies of which are filed herein as Exhibits 3.1 and 3.2,
provide for advancement of expenses and indemnification of officers and
directors of Cubist and certain other persons against liabilities and expenses
incurred by any of them in certain stated proceedings and under certain stated
conditions to the fullest extent permissible under Delaware law.
Cubist intends to maintain insurance for the benefit
of its directors and officers insuring such persons against certain
liabilities, including liabilities under the securities laws.
3
Item 7.
Exemption from
Registration Claimed
Not applicable.
Item 8.
Exhibits
The following exhibits are filed as part of this registration statement:
3.1
Restated
  Certificate of Incorporation Cubist (incorporated by reference to Exhibit 3
  to Cubist's Quarterly Report on Form 10-Q filed on August 6, 2004) (File no.
  000-21379).
3.2
Amended
  and Restated By-Laws of Cubist, as amended to date. (incorporated by
  reference to Exhibit 3.4, Registration No. 333-06795).
4.1
Specimen
  certificate for shares of Common Stock (incorporated by reference to Exhibit
  4.1 to Cubist's Annual Report on Form 10-K filed on March 1, 2006)
  (Registration No. 000-21379).
4.2
Rights
  Agreement dated as of July 21, 1999 between Cubist and Computershare Trust
  Company N.A. (f/k/a
EquiServe Trust Company, N.A. f/k/a Fleet National
  Bank f/k/a BankBoston, N.A.),
as
  Rights Agent (incorporated herein by reference to Exhibit 4.1 to the
  Company's Registration Statement on Form 8-A/A filed on August 5, 2005) (File
  No. 000-21379).
4.3
First
  Amendment, dated as of March 7, 2000, to the Rights Agreement, dated as of
  July 21, 1999 between the Company and Computershare Trust Company N.A. (f/k/a
EquiServe Trust Company, N.A. f/k/a Fleet National Bank f/k/a
  BankBoston, N.A.)
, as Rights Agent
  (incorporated herein by reference to Exhibit 4.2 to the Company's
  Registration Statement on Form 8-A/A filed on August 5, 2005) (File No.
  000-21379).
4.4
Amendment,
  dated as of March 20, 2002, to the Rights Agreement, dated as of July 21,
  1999 between the Company and Computershare Trust Company N.A. (f/k/a
EquiServe
  Trust Company, N.A. f/k/a Fleet National Bank f/k/a BankBoston, N.A.)
, as Rights Agent (incorporated herein by
  reference to Exhibit 4.3 to the Company's Registration Statement on Form
  8-A/A filed on August 5, 2005) (File No. 000-21379).
4.5
Third
  Amendment, dated as of August 2, 2005, to the Rights Agreement, dated as of
  July 21, 1999 between the Company and Computershare Trust Company N.A. (f/k/a
EquiServe Trust Company, N.A. f/k/a Fleet National Bank f/k/a
  BankBoston, N.A.)
, as Rights Agent
  (incorporated herein by reference to Exhibit 4.4 to the Company's
  Registration Statement on Form 8-A/A filed on August 5, 2005) (File No.
  000-21379).
4.6
Form
  of Amended Rights Certificate (incorporated herein by reference to Exhibit
  4.4 to the Company's Registration Statement on Form 8-A/A filed on March 9,
  2000) (File No. 000-21379).
5
Opinion
  of Bingham McCutchen LLP with respect to the legality of the shares being
  registered.
23.1
Consent
  of Bingham McCutchen LLP (included in Exhibit 5).
23.2
Consent
  of
Independent Registered Public Accounting Firm
.
24
Power
  of Attorney (included in signature page to registration statement).
4
Item 9.
Undertakings
The undersigned registrant hereby undertakes:
(1)
To file, during any period in which offers or sales
are being made, a post-effective amendment to this registration statement to
include any material information with respect to the plan of distribution not
previously disclosed in this registration statement or any material change to
such information in this registration statement;
(2)
That, for the purpose of determining any liability
under the Securities Act of 1933, each such post-effective amendment shall be
deemed to be a new registration statement relating to the securities offered
therein, and the offering of such securities at that time shall be deemed to be
the initial
bona fide
offering thereof;
(3)
To remove from registration by means of a
post-effective amendment any of the securities being registered which remain
unsold at the termination of the offering;
(4)
That, for purposes of determining any liability
under the Securities Act of 1933, each filing of the registrant's annual report
pursuant to Section 13(a) or 15(d) of the Exchange Act of 1934 (and, where
applicable, each filing of an employee benefit plan's annual report pursuant to
Section 15(d) of the Exchange Act of 1934) that is incorporated by reference in
this registration statement shall be deemed to be a new registration statement
relating to the securities offered therein, and the offering of such securities
at that time shall be deemed to be the initial
bona fide
offering thereof; and
(5)
Insofar as indemnification for liabilities arising
under the Securities Act of 1933 may be permitted to directors, officers and
controlling persons of the registrant pursuant to the foregoing provisions, or
otherwise, the registrant has been advised that in the opinion of the
Securities and Exchange Commission such indemnification is against public
policy as expressed in the Securities Act and is, therefore,
unenforceable.  In the event that a claim
for indemnification against such liabilities (other than the payment by the
registrant of expenses incurred or paid by a director, officer or controlling
person of the registrant in the successful defense of any action, suit or
proceeding) is asserted by such director, officer or controlling person in
connection with the securities being registered, the registrant will, unless in
the opinion of its counsel the matter has been settled by controlling
precedent, submit to a court of appropriate jurisdiction the question whether
such indemnification by it is against public policy as expressed in the
Securities Act and will be governed by the final adjudication of such issue.
5
SIGNATURES
Pursuant to the requirements of the Securities Act of 1933, as amended,
the registrant, Cubist Pharmaceuticals, Inc., certifies that it has reasonable
grounds to believe that it meets all of the requirements for filing on Form S-8
and has duly caused this registration statement to be signed on its behalf by
the undersigned, thereunto duly authorized, in the Town of Lexington,
Commonwealth of Massachusetts, on this 7th day of March, 2006.
CUBIST PHARMACEUTICALS,
  INC.
By:
/s/ Michael W. Bonney
Michael W. Bonney
President and Chief
  Executive Officer
POWER OF
ATTORNEY
Each person whose signature appears below hereby appoints each of
Michael
W. Bonney and David W.J. McGirr severally
, acting alone and without the other, his true and lawful attorney-in-fact
with the authority to execute in the name of each such person, and to file with
the Securities and Exchange Commission, together with any exhibits thereto and
other documents therewith, any and all amendments (including without limitation
post-effective amendments) to this registration statement on Form S-8 necessary
or advisable to enable the registrant to comply with the Securities Act of
1933, as amended, and any rules, regulations, and requirements of the
Securities and Exchange Commission in respect thereof, which amendments may
make such other changes in the Registration Statement as the aforesaid
attorney-in-fact executing the same deems appropriate.
Pursuant
to the requirements of the Securities Act of 1933, as amended, this
registration statement has been signed by the following persons in the
capacities and on the date indicated.
Signature
Title
Date
/s/ Michael W. Bonney
President, Chief
  Executive Officer and
March 7, 2006
Michael W.
  Bonney
Director
(Principal
  Executive Officer)
/s/ David W.J.
  McGirr
Senior Vice
  President
March 7, 2006
David W.J.
  McGirr
and Chief
  Financial Officer
(Principal
  Financial and Accounting Officer)
/s/ Kenneth M.
  Bate
Director
March 7, 2006
Kenneth M. Bate
/s/ David W.
  Martin, Jr.
Director
March 7, 2006
David W. Martin,
  Jr.
/s/ Walter R.
  Maupay, Jr.
Director
March 7, 2006
Walter R.
  Maupay, Jr.
/s/ Martin
  Rosenberg
Director
March 7, 2006
Martin Rosenberg
/s/ J. Matthew
  Singleton
Director
March 7, 2006
J. Matthew
  Singleton
/s/ Michael B.
  Wood
Director
March 7, 2006
Michael B. Wood
6
INDEX TO
EXHIBITS
Exhibit
Number
Description
3.1
Restated
  Certificate of Incorporation Cubist (incorporated by reference to Exhibit 3
  to Cubist's Quarterly Report on Form 10-Q filed on August 6, 2004) (File no.
  000-21379).
3.2
Amended
  and Restated By-Laws of Cubist, as amended to date. (incorporated by
  reference to Exhibit 3.4, Registration No. 333-06795).
4.1
Specimen
  certificate for shares of Common Stock (incorporated by reference to Exhibit
  4.1 to Cubist's Annual Report on Form 10-K filed on March 1, 2006)
  (Registration No. 000-21379).
4.2
Rights
  Agreement dated as of July 21, 1999 between Cubist and Computershare Trust
  Company N.A. (f/k/a
EquiServe Trust Company, N.A. f/k/a Fleet National
  Bank f/k/a BankBoston, N.A.),
as
  Rights Agent (incorporated herein by reference to Exhibit 4.1 to the
  Company's Registration Statement on Form 8-A/A filed on August 5, 2005) (File
  No. 000-21379).
4.3
First
  Amendment, dated as of March 7, 2000, to the Rights Agreement, dated as of
  July 21, 1999 between the Company and Computershare Trust Company N.A. (f/k/a
EquiServe Trust Company, N.A. f/k/a Fleet National Bank f/k/a
  BankBoston, N.A.)
, as Rights Agent
  (incorporated herein by reference to Exhibit 4.2 to the Company's
  Registration Statement on Form 8-A/A filed on August 5, 2005) (File No.
  000-21379).
4.4
Amendment,
  dated as of March 20, 2002, to the Rights Agreement, dated as of July 21,
  1999 between the Company and Computershare Trust Company N.A. (f/k/a
EquiServe
  Trust Company, N.A. f/k/a Fleet National Bank f/k/a BankBoston, N.A.)
, as Rights Agent (incorporated herein by reference
  to Exhibit 4.3 to the Company's Registration Statement on Form 8-A/A filed on
  August 5, 2005) (File No. 000-21379).
4.5
Third
  Amendment, dated as of August 2, 2005, to the Rights Agreement, dated as of
  July 21, 1999 between the Company and Computershare Trust Company N.A. (f/k/a
EquiServe Trust Company, N.A. f/k/a Fleet National Bank f/k/a
  BankBoston, N.A.)
, as Rights Agent
  (incorporated herein by reference to Exhibit 4.4 to the Company's
  Registration Statement on Form 8-A/A filed on August 5, 2005) (File No.
  000-21379).
4.6
Form
  of Amended Rights Certificate (incorporated herein by reference to Exhibit
  4.4 to the Company's Registration Statement on Form 8-A/A filed on March 9,
  2000) (File No. 000-21379).
5
Opinion
  of Bingham McCutchen LLP with respect to the legality of the shares being
  registered.
23.1
Consent
  of Bingham McCutchen LLP (included in Exhibit 5).
23.2
Consent
  of
Independent Registered Public Accounting Firm
.
24
Power
  of Attorney (included in signature page to registration statement).
7