<PAGE>


    As filed with the Securities and Exchange Commission on March 1, 2001
                                                           Registration No. 333-
================================================================================
                       SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549
                              --------------------
                                    FORM S-8
                             REGISTRATION STATEMENT
                        Under The Securities Act of 1933
                               -------------------

                        MEDICAL TECHNOLOGY SYSTEMS, INC.
             (Exact name of registrant as specified in its charter)


             Delaware                                   59-2740462
  (State or other jurisdiction              (I.R.S. Employer Identification No.)
of incorporation or organization)

12920 Automobile Boulevard, Clearwater, Florida                          33762
  (Address of Principal Executive Office)                             (Zip Code)


                        MEDICAL TECHNOLOGY SYSTEMS, INC.
                             1997 STOCK OPTION PLAN
                            (Full title of the plan)
                               -------------------

                                 Todd E. Siegel
                        Medical Technology Systems, Inc.
                           12920 Automobile Boulevard
                            Clearwater, Florida 33762
                     (Name and address of agent for service)
                                 (727) 576-6311
          (Telephone number, including area code, of agent for service)

                        Copies of all communications to:

                             Robert J. Grammig, Esq.
                              Holland & Knight LLP
                             400 North Ashley Drive
                                   Suite 2300
                              Tampa, Florida 33602
                                 (813) 227-8500

     If any of the securities being registered on this Form are to be offered on
delayed or continuous  basis  pursuant to Rule 415 under the  Securities  Act of
1933, check the following box.

<TABLE>
<CAPTION>
                         CALCULATION OF REGISTRATION FEE
---------------------------------------------- ------------------ ---------------- ----------------- -------------
                                                                                       Proposed
                  Title of                          Amount           Proposed          Maximum        Amount of
                 Securities                          to be            Maximum         Aggregate      registration
              to be registered                   Registered(1)    Offering price       Offering          fee
                                                                    per unit(2)        price(2)
---------------------------------------------- ------------------ ---------------- ----------------- -------------
<S>                                                <C>               <C>              <C>             <C>
Common stock, par value $0.01 per share
reserved under Medical Technology Systems,         1,500,000         $1.78            $2,670,000      $667.50
Inc. 1997 Stock Option Plan
---------------------------------------------- ------------------ ---------------- ----------------- -------------
</TABLE>

(1)The  provisions of Rule 416 under the  Securities  Act of 1933 shall apply to
this  Registration  Statement  and  the  number  of  shares  registered  on this
Registration  Statement  shall increase or decrease as a result of stock splits,
stock dividends or similar transactions.

(2)Estimated solely for the purpose of calculating the registration fee. The fee
is  calculated  upon the  basis of the  average  between  the high and low sales
prices for  shares of common  stock of the  registrant  as  reported  on the OTC
Bulletin Board on February 27, 2001.

================================================================================

<PAGE>
                                       1


                                     PART II

                 INFORMATION REQUIRED IN REGISTRATION STATEMENT


ITEM 3.  INCORPORATION OF DOCUMENTS BY REFERENCE

     The  following  documents  filed  with the  Commission  by the  Registrant,
Medical Technology Systems,  Inc., a Delaware  corporation,  are incorporated by
reference in this Registration Statement;

     (a)  The  Registrant's  Annual Report on Form 10-K for the year ended March
          31, 2000 (including information specifically incorporated by reference
          into the  Company's  Form 10-K  from the  Company's  definitive  Proxy
          Statement).

     (b)  The Registrant's Current Report on Form 8-K filed on July 17, 2000.

     (c)  The  Registrant's  Quarterly  Report on Form  10-Q  filed on August 9,
          2000.

     (d)  The  Registrant's  Quarterly  Report on Form 10-Q filed on November 7,
          2000.

     (e)  The  Registrant's  Amended  Quarterly  Report on Form 10-Q/A  filed on
          December 1, 2000.

     (f)  The  Registrant's  Quarterly  Report on Form 10-Q filed on February 6,
          2001.

     (g)  All documents  subsequently  filed by the Company pursuant to Sections
          13(a), 13(c), 14 and 15(d) of the Exchange Act, prior to the filing of
          a post-effective amendment which indicates that all securities offered
          hereby  have  been  sold or  which  deregisters  all  securities  then
          remaining  unsold,  shall be deemed to be incorporated by reference in
          this  Registration  Statement  and to be part  hereof from the date of
          filing of such documents.


ITEM 4.  DESCRIPTION OF SECURITIES

     Our  common  stock is listed on the OTC  Bulletin  Board  under the  symbol
"MDTY."  Each holder of our common  stock is entitled to one vote for each share
held. Stockholders do not have the right to cumulate their votes in elections of
directors.  Accordingly,  holders  of a majority  of the issued and  outstanding
common stock have the right to elect all of our directors and otherwise  control
us, subject to any voting rights of the then  outstanding  preferred  stock,  if
any.  Holders of our common  stock will be entitled to  dividends  on a pro rata
basis upon  declaration  of  dividends by our board of  directors,  out of funds
legally available for the payment of dividends. Upon our liquidation, holders of
our common  stock will be  entitled  to a pro rata  distribution  of our assets,
after  payment  of  all  amounts  owed  to our  creditors,  and  subject  to any
preferential  amount  payable to holders of our  preferred  stock,  if any.  The
holders of our common stock have no  preemptive  rights and no rights to convert
their common stock into any other  securities.  There are also no  redemption or
sinking fund provisions  applicable to the common stock. All outstanding  shares
of common stock are fully paid and nonassessable.

ITEM 5.  INTERESTS OF NAMED EXPERTS AND COUNSEL

     Not applicable.


ITEM 6.  INDEMNIFICATION OF DIRECTORS AND OFFICERS

     The  Registrant  is a Delaware  corporation.  Section  145 of the  Delaware
General  Corporation  Law (the "GCL")  provides that a corporation may indemnify
directors  and  officers  as well as other  employees  and  individuals  against
expenses  (including  attorneys'  fees),  judgments,  fines and  amount  paid in
settlement in connection with specified actions,  suits or proceedings,  whether
civil, criminal,  administrative or investigative (other than an action by or in
the right of the corporation - - a "derivative  action"),  if they acted in good
faith and in a manner  they  reasonably  believed to be in or not opposed to the
best interests of the corporation.


<PAGE>
                                       2


     A similar standard is applicable in the case of derivative actions,  except
that  indemnification  only  extends to  expenses  (including  attorneys'  fees)
incurred in connection  with the defense or settlement of such actions,  and the
statute  requires court approval before there can be any  indemnification  where
the person seeking indemnification has been found liable to the corporation. The
statute provides that it is not exclusive of other  indemnification  that may be
granted  by a  corporation's  charter,  by-laws,  disinterested  director  vote,
stockholder  vote,  agreement  or  otherwise.   The  Registrant's   Articles  of
Incorporation  and Bylaws  require the  Registrant to indemnify its officers and
directors to the fullest extent permitted under the GCL.

     The Registrant has purchased insurance with respect to, among other things,
any liabilities that may arise under the statutory provisions referred to above,
and has entered into  individual  indemnification  agreements with its directors
and officers regarding the same. These agreements require the Registrant,  among
other things,  to indemnify them against certain  liabilities  that may arise by
reason  of their  status  or  service  as  directors  or  officers  (other  than
liabilities arising from actions that were illegal,  fraudulent,  dishonest,  or
willful  misconduct),  to advance  their  expenses  incurred  as a result of any
proceeding  against  them as to which  they  could be  indemnified  (subject  to
certain  conditions),  and to obtain  liability  insurance for any director with
terms of insurance no less  favorable  than those provided to any other director
of the Registrant, and for any officer with terms of insurance no less favorable
than  those  provided  to any  other  officer  of  the  Registrant.  Insofar  as
indemnification  for liabilities arising under the Securities Act of 1933 may be
permitted to directors,  officers or persons controlling the Registrant pursuant
to the  foregoing  provisions,  the  Registrant  has been  informed  that in the
opinion of the  Securities  and Exchange  Commission,  such  indemnification  is
against  public  policy  as  expressed  in the  Securities  Act of  1933  and is
therefore   unenforceable.   The  Registrant   believes  that  its  Articles  of
Incorporation,  Bylaw provisions and indemnification agreements are necessary to
attract and retain qualified persons as directors and officers.


ITEM 7.  EXEMPTION FROM REGISTRATION CLAIMED.

         Not applicable.


ITEM 8.  EXHIBITS.

     4.1  Medical Technology Systems, Inc. 1997 Stock Option Plan.

     5.1  Opinion of Holland & Knight LLP re: legality of the Common Stock.

     23.1 Consent of Holland & Knight LLP (included in Exhibit 5.1).

     23.2 Independent Auditors' Consent.

     24.1 Powers of Attorney (included on signature page).


ITEM 9.  UNDERTAKINGS.

     (a)  The undersigned registrant hereby undertakes:

          (1) To file,  during  any  period  in which  offers or sales are being
     made, a post-effective amendment to this registration statement:

               (i)  To include any  prospectus  required by section  10(a)(3) of
                    the Securities Act of 1933;

               (ii) To reflect  in the  prospectus  any facts or events  arising
                    after the effective date of the  registration  statement (or
                    the most recent  post-effective  amendment  thereof)  which,
                    individually  or in the  aggregate,  represent a fundamental
                    change  in the  information  set  forth in the  registration
                    statement;

               (iii)To include  any  material  information  with  respect to the
                    plan  of  distribution  not  previously   disclosed  in  the
                    registration  statement  or  any  material  change  to  such
                    information in the registration statement.


<PAGE>
                                       3


          Provided,  however,  that  paragraphs  (a)(1)(i) and (a)(1)(ii) do not
     apply  if the  information  required  to be  included  in a  post-effective
     amendment by those paragraphs is contained in periodic reports filed by the
     registrant  pursuant  to  section  13 or  section  15(d) of the  Securities
     Exchange Act of 1934 that are incorporated by reference in the registration
     statement.

          (2) That,  for the  purpose of  determining  any  liability  under the
     Securities Act of 1933, each such post-effective  amendment shall be deemed
     to be a new  registration  statement  relating  to the  securities  offered
     herein, and the offering of such securities at that time shall be deemed to
     be the initial bona fide offering thereof.

          (3) To remove from registration by means of a post-effective amendment
     any  of  the  securities  being  registered  which  remain  unsold  at  the
     termination of the offering.

     (b) The  undersigned  registrant  hereby  undertakes  that, for purposes of
determining  any  liability  under  the  Securities  Act,  each  filing  of  the
registrant's  annual  report  pursuant to section  13(a) or section 15(d) of the
Exchange Act (and, where  applicable,  each filing of an employee benefit plan's
annual  report   pursuant  to  section  15(d)  of  the  Exchange  Act)  that  is
incorporated by reference in the registration  statement shall be deemed to be a
new registration  statement relating to the securities offered therein,  and the
offering of such  securities at that time shall be deemed to be the initial bona
fide offering thereof.

     (c) Insofar as indemnification for liabilities arising under the Securities
Act may be  permitted to  directors,  officers  and  controlling  persons of the
registrant pursuant to the foregoing  provisions (see Item 6) or otherwise,  the
registrant  has  been  advised  that  in  the  opinion  of the  Commission  such
indemnification  is against public policy as expressed in the Securities Act and
is,  therefore,  unenforceable.  In the event  that a claim for  indemnification
against such  liabilities  (other than the payment by the registrant of expenses
incurred or paid by a director,  officer or controlling person of the registrant
in the successful defense of any action, suit or proceeding) is asserted by such
director,  officer or controlling person in connection with the securities being
registered, the registrant will, unless in the opinion of its counsel the matter
has been  settled by  controlling  precedent,  submit to a court of  appropriate
jurisdiction the question whether such  indemnification  by it is against public
policy as  expressed  in the  Securities  Act and will be  governed by the final
adjudication of such issue.


<PAGE>
                                       4


                                   SIGNATURES

     Pursuant to the requirements of the Securities Act of 1933, the Registrant,
Medical Technology Systems, Inc., a corporation organized and existing under the
laws of the State of  Delaware,  certifies  that it has  reasonable  grounds  to
believe  that it meets all of the  requirements  for  filing on Form S-8 and has
duly  caused  this  Registration  Statement  to be signed  on its  behalf by the
undersigned,  thereunto duly  authorized,  in the City of  Clearwater,  State of
Florida, on February 27, 2001.

                                              MEDICAL TECHNOLOGY SYSTEMS, INC.


                                              By:/s/Todd E. Siegel
                                                 _____________________________
                                                 TODD E. SIEGEL
                                                 CHIEF EXECUTIVE OFFICER


                                POWER OF ATTORNEY

     KNOWN TO ALL PERSONS BY THESE PRESENTS,  we, the  undersigned  officers and
directors of Medical Technology Systems,  Inc., hereby severally  constitute and
appoint  Todd  E.  Siegel  and  Michael  P.  Conroy,  each  acting  alone  as an
attorney-in-fact  with the full power of substitution,  for him and in his name,
place and stead in any and all  capacities,  to sign any and all  amendments  to
this  Registration  Statement,  and to file the same, with all exhibits thereto,
and other  documents in connection  therewith,  with the Securities and Exchange
Commission, hereby ratifying and confirming all that said attorneys-in-fact,  or
either of their substitute or substitutes,  may do or cause to be done by virtue
hereof.

     Pursuant  to  the   requirements  of  the  Securities  Act  of  1933,  this
registration  statement  has  been  signed  by  the  following  persons  in  the
capacities and on the dates indicated.


       Signature                         Title                        Date
----------------------  -------------------------------------  -----------------


 /s/Todd E. Siegel      Chairman of the Board of Directors,    February 27, 2001
 ---------------------  President and Chief Executive Officer
  TODD E. SIEGEL


 /s/David W. Kazarian   Director                               February 27, 2001
 ---------------------
 DAVID W. KAZARIAN


 /s/Michael P. Conroy   Director, Chief Financial Officer      February 27, 2001
 ---------------------  and Vice President
 MICHAEL P. CONROY


 /s/John Stanton        Director and Vice Chairman of the      February 27, 2001
----------------------  Board of Directors
 JOHN STANTON


 /s/Mark J. Connolly    Principal Accounting Officer           February 27, 2001
----------------------  and Controller
 MARK J. CONNOLLY


<PAGE>
                                       10


                                INDEX OF EXHIBITS

     4.1 Medical Technology Systems, Inc. 1997 Stock Option Plan.

     5.1 Opinion of Holland & Knight LLP re legality of the Common Stock.

     23.1 Consent of Holland & Knight LLP (included in Exhibit 5.1).

     23.2 Independent Auditors' Consent.

     24.1 Powers of Attorney (included on signature page).

-----------------------
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As filed with the Securities and Exchange Commission on March 1, 2001
                                                           Registration No. 333-
================================================================================
                       SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549
                              --------------------
                                    FORM S-8
                             REGISTRATION STATEMENT
                        Under The Securities Act of 1933
                               -------------------

                        MEDICAL TECHNOLOGY SYSTEMS, INC.
             (Exact name of registrant as specified in its charter)

             Delaware                                   59-2740462
  (State or other jurisdiction              (I.R.S. Employer Identification No.)
of incorporation or organization)

12920 Automobile Boulevard, Clearwater, Florida                          33762
  (Address of Principal Executive Office)                             (Zip Code)

                        MEDICAL TECHNOLOGY SYSTEMS, INC.
                             1997 STOCK OPTION PLAN
                            (Full title of the plan)
                               -------------------

                                 Todd E. Siegel
                        Medical Technology Systems, Inc.
                           12920 Automobile Boulevard
                            Clearwater, Florida 33762
                     (Name and address of agent for service)
                                 (727) 576-6311
          (Telephone number, including area code, of agent for service)

                        Copies of all communications to:

                             Robert J. Grammig, Esq.
                              Holland & Knight LLP
                             400 North Ashley Drive
                                   Suite 2300
                              Tampa, Florida 33602
                                 (813) 227-8500

     If any of the securities being registered on this Form are to be offered on
delayed or continuous  basis  pursuant to Rule 415 under the  Securities  Act of
1933, check the following box.
CALCULATION OF REGISTRATION FEE
---------------------------------------------- ------------------ ---------------- ----------------- -------------
                                                                                       Proposed
                  Title of                          Amount           Proposed          Maximum        Amount of
                 Securities                          to be            Maximum         Aggregate      registration
              to be registered                   Registered(1)    Offering price       Offering          fee
                                                                    per unit(2)        price(2)
---------------------------------------------- ------------------ ---------------- ----------------- -------------
Common stock, par value $0.01 per share
reserved under Medical Technology Systems,         1,500,000         $1.78            $2,670,000      $667.50
Inc. 1997 Stock Option Plan
---------------------------------------------- ------------------ ---------------- ----------------- -------------
(1)The  provisions of Rule 416 under the  Securities  Act of 1933 shall apply to
this  Registration  Statement  and  the  number  of  shares  registered  on this
Registration  Statement  shall increase or decrease as a result of stock splits,
stock dividends or similar transactions.

(2)Estimated solely for the purpose of calculating the registration fee. The fee
is  calculated  upon the  basis of the  average  between  the high and low sales
prices for  shares of common  stock of the  registrant  as  reported  on the OTC
Bulletin Board on February 27, 2001.

================================================================================
1

                                     PART II

                 INFORMATION REQUIRED IN REGISTRATION STATEMENT

ITEM 3.  INCORPORATION OF DOCUMENTS BY REFERENCE

     The  following  documents  filed  with the  Commission  by the  Registrant,
Medical Technology Systems,  Inc., a Delaware  corporation,  are incorporated by
reference in this Registration Statement;

     (a)  The  Registrant's  Annual Report on Form 10-K for the year ended March
          31, 2000 (including information specifically incorporated by reference
          into the  Company's  Form 10-K  from the  Company's  definitive  Proxy
          Statement).

     (b)  The Registrant's Current Report on Form 8-K filed on July 17, 2000.

     (c)  The  Registrant's  Quarterly  Report on Form  10-Q  filed on August 9,
          2000.

     (d)  The  Registrant's  Quarterly  Report on Form 10-Q filed on November 7,
          2000.

     (e)  The  Registrant's  Amended  Quarterly  Report on Form 10-Q/A  filed on
          December 1, 2000.

     (f)  The  Registrant's  Quarterly  Report on Form 10-Q filed on February 6,
          2001.

     (g)  All documents  subsequently  filed by the Company pursuant to Sections
          13(a), 13(c), 14 and 15(d) of the Exchange Act, prior to the filing of
          a post-effective amendment which indicates that all securities offered
          hereby  have  been  sold or  which  deregisters  all  securities  then
          remaining  unsold,  shall be deemed to be incorporated by reference in
          this  Registration  Statement  and to be part  hereof from the date of
          filing of such documents.

ITEM 4.  DESCRIPTION OF SECURITIES

     Our  common  stock is listed on the OTC  Bulletin  Board  under the  symbol
"MDTY."  Each holder of our common  stock is entitled to one vote for each share
held. Stockholders do not have the right to cumulate their votes in elections of
directors.  Accordingly,  holders  of a majority  of the issued and  outstanding
common stock have the right to elect all of our directors and otherwise  control
us, subject to any voting rights of the then  outstanding  preferred  stock,  if
any.  Holders of our common  stock will be entitled to  dividends  on a pro rata
basis upon  declaration  of  dividends by our board of  directors,  out of funds
legally available for the payment of dividends. Upon our liquidation, holders of
our common  stock will be  entitled  to a pro rata  distribution  of our assets,
after  payment  of  all  amounts  owed  to our  creditors,  and  subject  to any
preferential  amount  payable to holders of our  preferred  stock,  if any.  The
holders of our common stock have no  preemptive  rights and no rights to convert
their common stock into any other  securities.  There are also no  redemption or
sinking fund provisions  applicable to the common stock. All outstanding  shares
of common stock are fully paid and nonassessable.

ITEM 5.  INTERESTS OF NAMED EXPERTS AND COUNSEL

     Not applicable.

ITEM 6.  INDEMNIFICATION OF DIRECTORS AND OFFICERS

     The  Registrant  is a Delaware  corporation.  Section  145 of the  Delaware
General  Corporation  Law (the "GCL")  provides that a corporation may indemnify
directors  and  officers  as well as other  employees  and  individuals  against
expenses  (including  attorneys'  fees),  judgments,  fines and  amount  paid in
settlement in connection with specified actions,  suits or proceedings,  whether
civil, criminal,  administrative or investigative (other than an action by or in
the right of the corporation - - a "derivative  action"),  if they acted in good
faith and in a manner  they  reasonably  believed to be in or not opposed to the
best interests of the corporation.
2

     A similar standard is applicable in the case of derivative actions,  except
that  indemnification  only  extends to  expenses  (including  attorneys'  fees)
incurred in connection  with the defense or settlement of such actions,  and the
statute  requires court approval before there can be any  indemnification  where
the person seeking indemnification has been found liable to the corporation. The
statute provides that it is not exclusive of other  indemnification  that may be
granted  by a  corporation's  charter,  by-laws,  disinterested  director  vote,
stockholder  vote,  agreement  or  otherwise.   The  Registrant's   Articles  of
Incorporation  and Bylaws  require the  Registrant to indemnify its officers and
directors to the fullest extent permitted under the GCL.

     The Registrant has purchased insurance with respect to, among other things,
any liabilities that may arise under the statutory provisions referred to above,
and has entered into  individual  indemnification  agreements with its directors
and officers regarding the same. These agreements require the Registrant,  among
other things,  to indemnify them against certain  liabilities  that may arise by
reason  of their  status  or  service  as  directors  or  officers  (other  than
liabilities arising from actions that were illegal,  fraudulent,  dishonest,  or
willful  misconduct),  to advance  their  expenses  incurred  as a result of any
proceeding  against  them as to which  they  could be  indemnified  (subject  to
certain  conditions),  and to obtain  liability  insurance for any director with
terms of insurance no less  favorable  than those provided to any other director
of the Registrant, and for any officer with terms of insurance no less favorable
than  those  provided  to any  other  officer  of  the  Registrant.  Insofar  as
indemnification  for liabilities arising under the Securities Act of 1933 may be
permitted to directors,  officers or persons controlling the Registrant pursuant
to the  foregoing  provisions,  the  Registrant  has been  informed  that in the
opinion of the  Securities  and Exchange  Commission,  such  indemnification  is
against  public  policy  as  expressed  in the  Securities  Act of  1933  and is
therefore   unenforceable.   The  Registrant   believes  that  its  Articles  of
Incorporation,  Bylaw provisions and indemnification agreements are necessary to
attract and retain qualified persons as directors and officers.

ITEM 7.  EXEMPTION FROM REGISTRATION CLAIMED.

         Not applicable.

ITEM 8.  EXHIBITS.

     4.1  Medical Technology Systems, Inc. 1997 Stock Option Plan.

     5.1  Opinion of Holland & Knight LLP re: legality of the Common Stock.

     23.1 Consent of Holland & Knight LLP (included in Exhibit 5.1).

     23.2 Independent Auditors' Consent.

     24.1 Powers of Attorney (included on signature page).

ITEM 9.  UNDERTAKINGS.

     (a)  The undersigned registrant hereby undertakes:

          (1) To file,  during  any  period  in which  offers or sales are being
     made, a post-effective amendment to this registration statement:

               (i)  To include any  prospectus  required by section  10(a)(3) of
                    the Securities Act of 1933;

               (ii) To reflect  in the  prospectus  any facts or events  arising
                    after the effective date of the  registration  statement (or
                    the most recent  post-effective  amendment  thereof)  which,
                    individually  or in the  aggregate,  represent a fundamental
                    change  in the  information  set  forth in the  registration
                    statement;

               (iii)To include  any  material  information  with  respect to the
                    plan  of  distribution  not  previously   disclosed  in  the
                    registration  statement  or  any  material  change  to  such
                    information in the registration statement.
3

          Provided,  however,  that  paragraphs  (a)(1)(i) and (a)(1)(ii) do not
     apply  if the  information  required  to be  included  in a  post-effective
     amendment by those paragraphs is contained in periodic reports filed by the
     registrant  pursuant  to  section  13 or  section  15(d) of the  Securities
     Exchange Act of 1934 that are incorporated by reference in the registration
     statement.

          (2) That,  for the  purpose of  determining  any  liability  under the
     Securities Act of 1933, each such post-effective  amendment shall be deemed
     to be a new  registration  statement  relating  to the  securities  offered
     herein, and the offering of such securities at that time shall be deemed to
     be the initial bona fide offering thereof.

          (3) To remove from registration by means of a post-effective amendment
     any  of  the  securities  being  registered  which  remain  unsold  at  the
     termination of the offering.

     (b) The  undersigned  registrant  hereby  undertakes  that, for purposes of
determining  any  liability  under  the  Securities  Act,  each  filing  of  the
registrant's  annual  report  pursuant to section  13(a) or section 15(d) of the
Exchange Act (and, where  applicable,  each filing of an employee benefit plan's
annual  report   pursuant  to  section  15(d)  of  the  Exchange  Act)  that  is
incorporated by reference in the registration  statement shall be deemed to be a
new registration  statement relating to the securities offered therein,  and the
offering of such  securities at that time shall be deemed to be the initial bona
fide offering thereof.

     (c) Insofar as indemnification for liabilities arising under the Securities
Act may be  permitted to  directors,  officers  and  controlling  persons of the
registrant pursuant to the foregoing  provisions (see Item 6) or otherwise,  the
registrant  has  been  advised  that  in  the  opinion  of the  Commission  such
indemnification  is against public policy as expressed in the Securities Act and
is,  therefore,  unenforceable.  In the event  that a claim for  indemnification
against such  liabilities  (other than the payment by the registrant of expenses
incurred or paid by a director,  officer or controlling person of the registrant
in the successful defense of any action, suit or proceeding) is asserted by such
director,  officer or controlling person in connection with the securities being
registered, the registrant will, unless in the opinion of its counsel the matter
has been  settled by  controlling  precedent,  submit to a court of  appropriate
jurisdiction the question whether such  indemnification  by it is against public
policy as  expressed  in the  Securities  Act and will be  governed by the final
adjudication of such issue.
4

                                   SIGNATURES

     Pursuant to the requirements of the Securities Act of 1933, the Registrant,
Medical Technology Systems, Inc., a corporation organized and existing under the
laws of the State of  Delaware,  certifies  that it has  reasonable  grounds  to
believe  that it meets all of the  requirements  for  filing on Form S-8 and has
duly  caused  this  Registration  Statement  to be signed  on its  behalf by the
undersigned,  thereunto duly  authorized,  in the City of  Clearwater,  State of
Florida, on February 27, 2001.

                                              MEDICAL TECHNOLOGY SYSTEMS, INC.

                                              By:/s/Todd E. Siegel
                                                 _____________________________
                                                 TODD E. SIEGEL
                                                 CHIEF EXECUTIVE OFFICER

                                POWER OF ATTORNEY

     KNOWN TO ALL PERSONS BY THESE PRESENTS,  we, the  undersigned  officers and
directors of Medical Technology Systems,  Inc., hereby severally  constitute and
appoint  Todd  E.  Siegel  and  Michael  P.  Conroy,  each  acting  alone  as an
attorney-in-fact  with the full power of substitution,  for him and in his name,
place and stead in any and all  capacities,  to sign any and all  amendments  to
this  Registration  Statement,  and to file the same, with all exhibits thereto,
and other  documents in connection  therewith,  with the Securities and Exchange
Commission, hereby ratifying and confirming all that said attorneys-in-fact,  or
either of their substitute or substitutes,  may do or cause to be done by virtue
hereof.

     Pursuant  to  the   requirements  of  the  Securities  Act  of  1933,  this
registration  statement  has  been  signed  by  the  following  persons  in  the
capacities and on the dates indicated.

       Signature                         Title                        Date
----------------------  -------------------------------------  -----------------

 /s/Todd E. Siegel      Chairman of the Board of Directors,    February 27, 2001
 ---------------------  President and Chief Executive Officer
  TODD E. SIEGEL

 /s/David W. Kazarian   Director                               February 27, 2001
 ---------------------
 DAVID W. KAZARIAN

 /s/Michael P. Conroy   Director, Chief Financial Officer      February 27, 2001
 ---------------------  and Vice President
 MICHAEL P. CONROY

 /s/John Stanton        Director and Vice Chairman of the      February 27, 2001
----------------------  Board of Directors
 JOHN STANTON

 /s/Mark J. Connolly    Principal Accounting Officer           February 27, 2001
----------------------  and Controller
 MARK J. CONNOLLY
10

                                INDEX OF EXHIBITS

     4.1 Medical Technology Systems, Inc. 1997 Stock Option Plan.

     5.1 Opinion of Holland & Knight LLP re legality of the Common Stock.

     23.1 Consent of Holland & Knight LLP (included in Exhibit 5.1).

     23.2 Independent Auditors' Consent.

     24.1 Powers of Attorney (included on signature page).

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