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  <!-- Field: Rule-Page --><DIV ALIGN="LEFT" STYLE="margin-top: 0; margin-bottom: 0"><DIV STYLE="font-size: 1pt; border-top: Black 2pt solid; border-bottom: Black 1pt solid; width: 100%">&nbsp;</DIV></DIV><!-- Field: /Rule-Page -->
  
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  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>UNITED STATES</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>SECURITIES AND EXCHANGE COMMISSION</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>WASHINGTON, D.C. 20549</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>FORM S-8</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>REGISTRATION STATEMENT</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>UNDER THE SECURITIES ACT OF 1933</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B><U>OptimizeRx Corp.</U></B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">(Exact name of registrant as specified in
  its charter)</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>
  
  <TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%">
  <TR STYLE="vertical-align: top">
      <TD STYLE="width: 49%; font-size: 10pt; text-align: center; border-bottom: Black 1.5pt solid"><FONT STYLE="font-size: 10pt"><B>Nevada</B></FONT></TD>
      <TD STYLE="width: 2%; padding-bottom: 1.5pt">&nbsp;</TD>
      <TD STYLE="width: 49%; font-size: 10pt; text-align: center; border-bottom: Black 1.5pt solid"><FONT STYLE="font-size: 10pt"><B>26-1265381</B></FONT></TD></TR>
  <TR STYLE="vertical-align: top">
      <TD STYLE="text-align: center; font-size: 10pt"><FONT STYLE="font-size: 10pt">(State or other jurisdiction of<BR>
  incorporation or organization)</FONT></TD>
      <TD>&nbsp;</TD>
      <TD STYLE="text-align: center; font-size: 10pt"><FONT STYLE="font-size: 10pt">(I.R.S. Employer<BR>
  Identification No.)</FONT></TD></TR>
  </TABLE>
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>400 Water Street, Suite 200,</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B><U>Rochester, MI 48307</U></B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">(Address of Principal Executive Offices)</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B><U>Amended and Restated OptimizeRx Corp.
  2013 Incentive Plan</U></B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">(Full title of the plan)</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>Spring Valley Solutions, LLC</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>4955 S. Durango Rd. Ste. 165</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B><U>Las Vegas, NV 89113</U></B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">(Name and address of agent for service)</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B><U>(248) 651-6568</U></B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">(Telephone number, including area Code,
  of agent for service)</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Indicate by check mark whether the Registrant is a large accelerated
  filer, an accelerated filer, a non-accelerated filer, a smaller reporting company or an emerging growth company. See the definitions
  of &ldquo;large accelerated filer,&rdquo; &ldquo;accelerated filer,&rdquo; &ldquo;smaller reporting company&rdquo; and &ldquo;emerging
  growth company&rdquo; in Rule 12b-2 of the Exchange Act.</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
  
  <TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
  <TR>
      <TD STYLE="width: 24%; text-align: justify"><FONT STYLE="font-size: 10pt">Large accelerated filer:</FONT></TD>
      <TD STYLE="width: 6%; text-align: left"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#9744;</FONT></TD>
      <TD STYLE="width: 10%; text-align: center">&nbsp;</TD>
      <TD STYLE="width: 24%; text-align: justify"><FONT STYLE="font-size: 10pt">Accelerated filer:</FONT></TD>
      <TD STYLE="width: 6%; text-align: left"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#9746;</FONT></TD>
      <TD STYLE="text-align: center">&nbsp;</TD></TR>
  <TR>
      <TD STYLE="text-align: justify"><FONT STYLE="font-size: 10pt">Non-accelerated filer:</FONT></TD>
      <TD STYLE="text-align: left"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#9744;</FONT></TD>
      <TD STYLE="text-align: center">&nbsp;</TD>
      <TD STYLE="text-align: justify"><FONT STYLE="font-size: 10pt">Smaller reporting company:</FONT></TD>
      <TD STYLE="text-align: left"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#9746;</FONT></TD>
      <TD STYLE="text-align: center">&nbsp;</TD></TR>
  <TR>
      <TD STYLE="text-align: justify">&nbsp;</TD>
      <TD STYLE="text-align: left">&nbsp;</TD>
      <TD STYLE="text-align: center">&nbsp;</TD>
      <TD STYLE="text-align: justify"><FONT STYLE="font-size: 10pt">Emerging growth company:</FONT></TD>
      <TD STYLE="text-align: left"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#9744;</FONT></TD>
      <TD STYLE="text-align: center">&nbsp;</TD></TR>
  <TR>
      <TD STYLE="text-align: justify">&nbsp;</TD>
      <TD STYLE="text-align: left">&nbsp;</TD>
      <TD STYLE="text-align: center">&nbsp;</TD>
      <TD STYLE="text-align: justify">&nbsp;</TD>
      <TD STYLE="text-align: left">&nbsp;</TD>
      <TD STYLE="text-align: center">&nbsp;</TD></TR>
  <TR>
      <TD COLSPAN="6" STYLE="vertical-align: top; text-align: justify"><FONT STYLE="font-size: 10pt">If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 7(a)(2)(B) of the Securities Act.</FONT> &#9744;</TD></TR>
  </TABLE>
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><FONT STYLE="font-variant: small-caps"><B>&nbsp;</B></FONT></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><FONT STYLE="font-variant: small-caps"><B>Calculation
  of Registration Fee</B></FONT></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
  
  <TABLE CELLPADDING="0" CELLSPACING="0" STYLE="border-collapse: collapse; width: 100%; font: 10pt Times New Roman, Times, Serif">
  <TR STYLE="vertical-align: bottom">
      <TD STYLE="border-bottom: Black 1.5pt solid; white-space: nowrap">Title of each class of securities to be registered</TD><TD STYLE="white-space: nowrap">&nbsp;</TD>
      <TD COLSPAN="2" STYLE="text-align: center; border-bottom: Black 1.5pt solid; white-space: nowrap"><P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">Amount</P> <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">to be</P> <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">registered <SUP>(1)</SUP></P></TD><TD STYLE="white-space: nowrap">&nbsp;</TD><TD STYLE="white-space: nowrap">&nbsp;</TD>
      <TD COLSPAN="2" STYLE="text-align: center; border-bottom: Black 1.5pt solid; white-space: nowrap"><P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">Proposed<BR>
  maximum<BR>
  offering<BR>
  price</P> <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">per share <SUP>(2)</SUP></P></TD><TD STYLE="white-space: nowrap">&nbsp;</TD><TD STYLE="white-space: nowrap">&nbsp;</TD>
      <TD COLSPAN="2" STYLE="text-align: center; border-bottom: Black 1.5pt solid; white-space: nowrap">Proposed<BR>
  maximum<BR>aggregate<BR>
  offering<BR>
  price</TD><TD STYLE="white-space: nowrap">&nbsp;</TD><TD STYLE="white-space: nowrap">&nbsp;</TD>
      <TD COLSPAN="2" STYLE="text-align: center; border-bottom: Black 1.5pt solid; white-space: nowrap">Amount of <BR>registration <BR>fee</TD><TD STYLE="white-space: nowrap">&nbsp;</TD></TR>
  <TR STYLE="vertical-align: bottom; background-color: rgb(204,238,255)">
      <TD STYLE="width: 52%">Common Stock $0.001 par value</TD><TD STYLE="width: 1%">&nbsp;</TD>
      <TD STYLE="width: 1%; text-align: left">&nbsp;</TD><TD STYLE="width: 9%; text-align: right">1,116,666</TD><TD STYLE="width: 1%; text-align: left">&nbsp;</TD><TD STYLE="width: 1%">&nbsp;</TD>
      <TD STYLE="width: 1%; text-align: left">$</TD><TD STYLE="width: 9%; text-align: right">14.72</TD><TD STYLE="width: 1%; text-align: left">&nbsp;</TD><TD STYLE="width: 1%">&nbsp;</TD>
      <TD STYLE="width: 1%; text-align: left">$</TD><TD STYLE="width: 9%; text-align: right">16,437,323.52</TD><TD STYLE="width: 1%; text-align: left">&nbsp;</TD><TD STYLE="width: 1%">&nbsp;</TD>
      <TD STYLE="width: 1%; text-align: left">$</TD><TD STYLE="width: 9%; text-align: right">1,992.20</TD><TD STYLE="width: 1%; text-align: left">&nbsp;</TD></TR>
  </TABLE>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
  
  <TABLE CELLPADDING="0" CELLSPACING="0" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 0; width: 100%"><TR STYLE="vertical-align: top; text-align: justify">
  <TD STYLE="width: 0"></TD><TD STYLE="width: 0.25in; text-align: left"><FONT STYLE="font-size: 10pt"><SUP>(1)</SUP></FONT></TD><TD STYLE="text-align: justify">An aggregate of 1,116,666 shares of Common Stock may be
  offered or issued pursuant to the Amended and Restated 2013 OptimizeRx Corp. 2015 Equity Incentive Plan (the &ldquo;Plan&rdquo;).
  In addition, pursuant to Rule 416(c) under the Securities Act of 1933, as amended (the &ldquo;Securities Act&rdquo;), this Registration
  Statement also covers an indeterminate number of shares of Common Stock that may be offered or issued by reason of stock splits,
  stock dividends or similar transactions that become issuable under the Plan.</TD>
  </TR></TABLE>
  
  
  
  <P STYLE="margin: 0">&nbsp;</P>
  
  <TABLE CELLPADDING="0" CELLSPACING="0" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 0; width: 100%"><TR STYLE="vertical-align: top; text-align: justify">
  <TD STYLE="width: 0"></TD><TD STYLE="width: 0.25in; text-align: left"><FONT STYLE="font-size: 10pt"><SUP>(2)</SUP></FONT></TD><TD STYLE="text-align: justify"><FONT STYLE="font-size: 10pt">Estimated in accordance with
  Rule 457(c) promulgated under the Securities Act solely for the purpose of calculating the amount of the registration fee on the
  basis of the average of the high and low price per share of the Registrant&rsquo;s Common Stock as reported on the Nasdaq Capital
  Market on March 8, 2019.</FONT></TD>
  </TR></TABLE>
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">This registration statement shall become effective upon filing
  in accordance with Rule 462 under the Securities Act.<FONT STYLE="font-size: 10pt">&nbsp;</FONT></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><FONT STYLE="font-size: 10pt">&nbsp;</FONT></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><FONT STYLE="font-size: 10pt"></FONT></P>
  
  <!-- Field: Rule-Page --><DIV ALIGN="LEFT" STYLE="margin-top: 0; margin-bottom: 0"><DIV STYLE="font-size: 1pt; border-top: Black 1pt solid; border-bottom: Black 2pt solid; width: 100%">&nbsp;</DIV></DIV><!-- Field: /Rule-Page -->
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><FONT STYLE="font-size: 10pt; font-variant: small-caps">&nbsp;</FONT></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><FONT STYLE="font-variant: small-caps"></FONT></P>
  
  <!-- Field: Page; Sequence: 1 -->
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      <DIV STYLE="page-break-before: always; margin-top: 6pt; margin-bottom: 12pt"><P STYLE="margin: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P></DIV>
      <!-- Field: /Page -->
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><FONT STYLE="font-variant: small-caps"><B>&nbsp;</B></FONT></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><FONT STYLE="font-variant: small-caps"><B><A NAME="toc"></A>Table
  of Contents</B></FONT></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
  
  <TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%">
  <TR STYLE="vertical-align: top; background-color: rgb(204,238,255)">
      <TD COLSPAN="2"><FONT STYLE="font-size: 10pt; font-variant: small-caps"><B><A HREF="#a_001">PART I</A></B></FONT></TD>
      <TD STYLE="text-align: center">1</TD></TR>
  <TR STYLE="vertical-align: top; background-color: White">
      <TD COLSPAN="2">&nbsp;</TD>
      <TD STYLE="text-align: center">&nbsp;</TD></TR>
  <TR STYLE="vertical-align: top; background-color: rgb(204,238,255)">
      <TD COLSPAN="2"><FONT STYLE="font-size: 10pt; font-variant: small-caps"><B><A HREF="#a_002">PART II</A></B></FONT></TD>
      <TD STYLE="text-align: center">2</TD></TR>
  <TR STYLE="vertical-align: top; background-color: White">
      <TD COLSPAN="2">&nbsp;</TD>
      <TD STYLE="text-align: center">&nbsp;</TD></TR>
  <TR STYLE="vertical-align: top; background-color: rgb(204,238,255)">
      <TD STYLE="width: 6%">&nbsp;</TD>
      <TD><FONT STYLE="font-size: 10pt; font-variant: small-caps"><B><A HREF="#a_003">Item 3. Incorporation of Documents by Reference.</A></B></FONT></TD>
      <TD STYLE="width: 9%; text-align: center">2</TD></TR>
  <TR STYLE="vertical-align: top; background-color: White">
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD STYLE="text-align: center">&nbsp;</TD></TR>
  <TR STYLE="vertical-align: top; background-color: rgb(204,238,255)">
      <TD>&nbsp;</TD>
      <TD><FONT STYLE="font-size: 10pt; font-variant: small-caps"><B><A HREF="#a_004">Item 4. Description of Securities.</A></B></FONT></TD>
      <TD STYLE="text-align: center">3</TD></TR>
  <TR STYLE="vertical-align: top; background-color: White">
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD STYLE="text-align: center">&nbsp;</TD></TR>
  <TR STYLE="vertical-align: top; background-color: rgb(204,238,255)">
      <TD>&nbsp;</TD>
      <TD><FONT STYLE="font-size: 10pt; font-variant: small-caps"><B><A HREF="#a_005">Item 5. Interests of Named Experts and Counsel.</A></B></FONT></TD>
      <TD STYLE="text-align: center">3</TD></TR>
  <TR STYLE="vertical-align: top; background-color: White">
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD STYLE="text-align: center">&nbsp;</TD></TR>
  <TR STYLE="vertical-align: top; background-color: rgb(204,238,255)">
      <TD>&nbsp;</TD>
      <TD><FONT STYLE="font-size: 10pt; font-variant: small-caps"><B><A HREF="#a_006">Item 6. Indemnification of Directors and Officers.</A></B></FONT></TD>
      <TD STYLE="text-align: center">3</TD></TR>
  <TR STYLE="vertical-align: top; background-color: White">
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD STYLE="text-align: center">&nbsp;</TD></TR>
  <TR STYLE="vertical-align: top; background-color: rgb(204,238,255)">
      <TD>&nbsp;</TD>
      <TD><FONT STYLE="font-size: 10pt; font-variant: small-caps"><B><A HREF="#a_007">Item 7. Exemption from Registration Claimed.</A></B></FONT></TD>
      <TD STYLE="text-align: center">4</TD></TR>
  <TR STYLE="vertical-align: top; background-color: White">
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD STYLE="text-align: center">&nbsp;</TD></TR>
  <TR STYLE="vertical-align: top; background-color: rgb(204,238,255)">
      <TD>&nbsp;</TD>
      <TD><FONT STYLE="font-size: 10pt; font-variant: small-caps"><B><A HREF="#a_008">Item 8. Exhibits.</A></B></FONT></TD>
      <TD STYLE="text-align: center">5</TD></TR>
  <TR STYLE="vertical-align: top; background-color: White">
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD STYLE="text-align: center">&nbsp;</TD></TR>
  <TR STYLE="vertical-align: top; background-color: rgb(204,238,255)">
      <TD>&nbsp;</TD>
      <TD><FONT STYLE="font-size: 10pt; font-variant: small-caps"><B><A HREF="#a_009">Item 9. Undertakings.</A></B></FONT></TD>
      <TD STYLE="text-align: center">6</TD></TR>
  <TR STYLE="vertical-align: top; background-color: White">
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD STYLE="text-align: center">&nbsp;</TD></TR>
  <TR STYLE="vertical-align: top; background-color: rgb(204,238,255)">
      <TD COLSPAN="2"><FONT STYLE="font-size: 10pt; font-variant: small-caps"><B><A HREF="#a_010">Signatures</A></B></FONT></TD>
      <TD STYLE="text-align: center">7</TD></TR>
  </TABLE>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"></P>
  
  <!-- Field: Page; Sequence: 2; Options: NewSection; Value: 1 -->
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      <DIV STYLE="page-break-before: always; margin-top: 6pt; margin-bottom: 12pt"><P STYLE="margin: 0pt; font: 10pt Times New Roman, Times, Serif"><A HREF="#toc">Table of Contents</A></P></DIV>
      <!-- Field: /Page -->
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; text-align: center; margin-bottom: 0pt"><A NAME="a_001"></A><B>PART I</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><FONT STYLE="font-variant: small-caps"><B>Information
  Required in the Section 10(A) Prospectus</B></FONT></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in; text-align: justify">The documents containing the information
  specified in Part I will be sent or given to participants in the Plan as specified by Rule 428(b)(1) of the Securities Act of 1933,
  as amended (the &ldquo;Securities Act&rdquo;). In accordance with the instructions of Part I of Form S-8, these documents will
  not be filed with the Securities and Exchange Commission (the &ldquo;SEC&rdquo;) either as part of this Registration Statement
  or as prospectuses or prospectus supplements pursuant to Rule 424 of the Securities Act. These documents and the documents incorporated
  by reference pursuant to Item 3 of Part II of this Registration Statement, taken together, constitute the prospectus as required
  by Section 10(a) of the Securities Act.</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">All requests should be directed to:</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B>OptimizeRx Corp.</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B>400 Water Street, Suite 200, </B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B>Rochester, MI 48307</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Attention: Douglas Baker</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Chief Financial Officer</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Or by calling: (<B>248) 651-6568</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"></P>
  
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  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; text-align: center; margin-bottom: 0pt"><A NAME="a_002"></A><B>PART II</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><FONT STYLE="font-variant: small-caps"><B>Information
  Required in the Registration Statement</B></FONT></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B><A NAME="a_003"></A>Item 3. Incorporation of Documents
  by Reference<FONT STYLE="font-variant: small-caps">.</FONT></B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in; text-align: justify">The SEC allows us to &ldquo;incorporate
  by reference&rdquo; the information we file with the SEC. This permits us to disclose important information to you by referring
  to these filed documents. Any information referred to in this way is considered part of this prospectus supplement. The information
  incorporated by reference is an important part of this prospectus supplement and the accompanying prospectus, and information that
  we file later with the SEC will automatically update and supersede this information. We incorporate by reference the following
  documents that have been filed with the SEC (other than information furnished under Item 2.02, Item 7.01 of Item 8.01 of Form 8-K
  and all exhibits related to such items):</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>
  
  <TABLE CELLPADDING="0" CELLSPACING="0" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 0; width: 100%"><TR STYLE="vertical-align: top; text-align: justify">
  <TD STYLE="width: 0.25in; text-align: justify"></TD><TD STYLE="width: 0.25in; text-align: justify">&#9679;</TD><TD STYLE="text-align: justify">Our Annual Report on Form 10-K for the fiscal year ended
  December 31, 2018, filed with the SEC on March 12, 2019;</TD>
  </TR>     <TR STYLE="vertical-align: top; text-align: justify">
  <TD STYLE="text-align: justify">&nbsp;</TD><TD STYLE="text-align: justify">&nbsp;</TD><TD STYLE="text-align: justify">&nbsp;</TD></TR>
  </TABLE>
  
  <TABLE CELLPADDING="0" CELLSPACING="0" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 0; width: 100%"><TR STYLE="vertical-align: top; text-align: justify">
  <TD STYLE="width: 0.25in; text-align: justify"></TD><TD STYLE="width: 0.25in; text-align: justify">&#9679;</TD><TD STYLE="text-align: justify">Current Reports on Form 8-K or 8-K/A, as the case
  may be, filed with the SEC on February 26, 2019, February 8, 2019, December 21, 2018, December 10, 2018, October 17, 2018, September
  14, 2018, March 27, 2018 and February 2, 2018; and</TD>
  </TR>     <TR STYLE="vertical-align: top; text-align: justify">
  <TD STYLE="text-align: justify">&nbsp;</TD><TD STYLE="text-align: justify">&nbsp;</TD><TD STYLE="text-align: justify">&nbsp;</TD></TR>
  </TABLE>
  
  <TABLE CELLPADDING="0" CELLSPACING="0" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 0; width: 100%"><TR STYLE="vertical-align: top; text-align: justify">
  <TD STYLE="width: 0.25in; text-align: justify"></TD><TD STYLE="width: 0.25in; text-align: justify">&#9679;</TD><TD STYLE="text-align: justify">The description of our common stock in our Registration
  Statement on Form S-3/A, filed with the SEC on December 11, 2018, including any amendment or reports filed for the purpose of
  updating such description.</TD>
  </TR></TABLE>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in; text-align: justify">In addition, all other documents filed (not
  furnished) by us pursuant to Section 13(a), Section 13(c), Section 14 or Section 15(d) of the Exchange Act on or after the date
  of this reoffer prospectus and prior to the termination of this offering, shall be deemed to be incorporated by reference into
  this reoffer prospectus and to be a part of this reoffer prospectus from the date of the filing of such documents; provided, however,
  that documents or information deemed to have been furnished to and not filed with the SEC in accordance with the rules of the SEC
  shall not be deemed incorporated by reference into this reoffer prospectus.</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in; text-align: justify">Any information in any of the foregoing
  documents will automatically be deemed to be modified or superseded to the extent that information in this prospectus supplement
  and the accompanying prospectus or in a later filed document that is incorporated or deemed to be incorporated herein by reference
  modifies or replaces such information.</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in; text-align: justify">You may request, orally or in writing, a
  copy of these documents, which will be provided to you at no cost (other than exhibits, unless such exhibits are specifically incorporate
  by reference), by contacting Douglas Baker, c/o OptimizeRx Corporation., at 400 Water Street, Suite 200, Rochester, MI 48307. Our
  telephone number is (248) 651-6568.</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in"></P>
  
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  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B><A NAME="a_004"></A>Item 4. Description of Securities.</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B>&nbsp;</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in; text-align: justify">Not Applicable.</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><B><A NAME="a_005"></A>Item 5. Interests of Named Experts and
  Counsel.</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in; text-align: justify">No expert or counsel named in this prospectus
  as having prepared or certified any part of it or as having given an opinion upon the validity of the securities being registered
  or upon other legal matters in connection with the registration or offering of the common stock was employed on a contingency basis,
  or had, or is to receive, in connection with the offering, a substantial interest, direct or indirect, in the Company or any of
  its parents or subsidiaries. Nor was any such person connected with the Company or any of its parents or subsidiaries as a promoter,
  managing or principal underwriter, voting trustee, director, officer, or employee.</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><B><A NAME="a_006"></A>Item 6. Indemnification of Directors and
  Officers.</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in; text-align: justify">The statutes, charter provisions, bylaws,
  contracts or other arrangements under which controlling persons, directors or officers of the registrant are insured or indemnified
  in any manner against any liability which they may incur in such capacity are as follows:</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in; text-align: justify">Section 78.751 of the Nevada Revised Statutes
  provides that each corporation shall have the following powers regarding indemnification:</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in; text-align: justify">1) A corporation may indemnify any person
  who was or is a party or is threatened to be made a party to any threatened, pending or completed action, suit or proceeding, whether
  civil, criminal, administrative or investigative, except an action by or in the right of the corporation, by reason of the fact
  that he is or was a director, officer, employee or agent of the corporation, or is or was serving at the request of the corporation
  as a director, officer, employee or agent of another corporation, partnership, joint venture, trust or other enterprise, against
  expenses, including attorneys&rsquo; fees, judgments, fines and amounts paid in settlement actually and reasonably incurred by him in
  connection with the action, suit or proceeding if he acted in good faith and in a manner which he reasonably believed to be in
  or not opposed to the best interest of the corporation, and, with respect to any criminal action or proceeding, had no reasonable
  cause to believe his conduct was unlawful. The termination of any action, suit or proceeding by judgment, order, settlement, conviction,
  or upon a plea of nolo contendere or its equivalent, does not, of itself create a presumption that the person did not act in good
  faith and in a manner which he reasonably believed to be in or not opposed to the best interests of the corporation, and that,
  with respect to any criminal action or proceeding, he had reasonable cause to believe that his conduct was unlawful.</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in; text-align: justify">2) A corporation may indemnify any person
  who was or is a party or is threatened to be made a party to any threatened, pending or completed action or suit by or in the right
  of the corporation to procure a judgment in its favor by reason of the fact that he is or was a director, officer, employee or
  agent of the corporation, or is or was serving at the request of the corporation as a director, officer, employee or agent of another
  corporation, partnership, joint venture, trust or other enterprise against expenses, including amounts paid in settlement and attorneys&rsquo;
  fees actually and reasonably incurred by him in connection with the defense or settlement of the action or suit if he acted in
  good faith and in a manner which he reasonably believed to be in or not opposed to the best interests of the corporation. Indemnification
  may not be made for any claim, issue or matter as to which such a person has been adjudged by a court of competent jurisdiction,
  after exhaustion of all appeals there from, to be liable to the corporation or for amounts paid in settlement to the corporation,
  unless and only to the extent that the court in which the action or suit was brought or other court of competent jurisdiction,
  determines upon application that in view of all the circumstances of the case, the person is fairly and reasonably entitled to
  indemnity such expenses as the court deems proper.</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"></P>
  
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  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in; text-align: justify">3) To the extent that a director, officer,
  employee or agent of a corporation has been successful on the merits or otherwise in defense of any action, suit or proceeding
  referred to in subsections 1 and 2, or in defense of any claim, issue or matter therein, he must be indemnified by the corporation
  against expenses, including attorneys&rsquo; fees, actually and reasonably incurred by him in connection with the defense.</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in; text-align: justify">4) Any indemnification under subsections
  1 and 2, unless ordered by a court or advanced pursuant to subsection 5, must be made by the corporation only as authorized in
  the specific case upon a determination that indemnification of the director, officer, employee or agent is proper in the circumstances.
  The determination must be made:</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in; text-align: justify">a) By the stockholders;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in; text-align: justify">b) By the board of directors by majority
  vote of a quorum consisting of directors who were not parties to the act, suit or proceeding;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in; text-align: justify">c) If a majority vote of a quorum consisting
  of directors who were not parties to the act, suit or proceeding so orders, by independent legal counsel, in a written opinion;
  or if a quorum consisting of directors who were not parties to the act, suit or proceeding cannot be obtained, by independent legal
  counsel in a written opinion.</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in; text-align: justify">d) The certificate or articles of incorporation,
  the bylaws or an agreement made by the corporation may provide that the expenses of officers and directors incurred in defending
  a civil or criminal action, suit or proceeding must be paid by the corporation as they are incurred and in advance of the final
  disposition of the action, suit or proceeding, upon receipt of an undertaking by or on behalf of the director or officer to repay
  the amount if it is ultimately determined by a court of competent jurisdiction that he is not entitled to be indemnified by the
  corporation. The provisions of this subsection do not affect any rights to advancement of expenses to which corporate personnel
  other than directors or officers may be entitled under any contract or otherwise by law.</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in; text-align: justify">5) The indemnification and advancement of
  expenses authorized in or ordered by a court pursuant to this section:</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in; text-align: justify">a) Does not exclude any other rights to
  which a person seeking indemnification or advancement of expenses may be entitled under the certificate or articles of incorporation
  or any bylaw, agreement, vote of stockholders of disinterested directors or otherwise, for either an action in his official capacity
  or an action in another capacity while holding his office, except that indemnification, unless ordered by a court pursuant to subsection
  2 or for the advancement of expenses made pursuant to subsection 5, may not be made to or on behalf of any director or officer
  if a final adjudication establishes that his acts or omissions involved intentional misconduct, fraud or a knowing violation of
  the law and was material to the cause of action.</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in; text-align: justify">b) Continues for a person who has ceased
  to be a director, officer, employee or agent and inures to the benefit of the heirs, executors and administrators of such a person.</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in; text-align: justify">Article VI of our Amended and Restated Bylaws
  also provides specific indemnification provisions for our officers, directors, employees and or agents to the fullest extent of
  the law.</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><B>&nbsp;</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><B><A NAME="a_007"></A>Item 7. Exemption from Registration Claimed.</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in; text-align: justify">Not applicable.</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"></P>
  
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  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B><A NAME="a_008"></A>Item 8. Exhibits.</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B>&nbsp;</B></P>
  
  <TABLE CELLSPACING="0" CELLPADDING="0" STYLE="width: 100%; border-collapse: collapse; font: 10pt Times New Roman, Times, Serif">
  <TR>
      <TD STYLE="vertical-align: top; width: 9%; border-bottom: black 1.5pt solid; padding-right: 3.2pt"><FONT STYLE="font-size: 10pt"><B>Exhibit Number</B></FONT></TD>
      <TD STYLE="width: 1%">&nbsp;</TD>
      <TD STYLE="vertical-align: bottom; width: 90%; border-bottom: black 1.5pt solid; padding-right: 0.8pt; text-align: justify"><FONT STYLE="font-size: 10pt"><B>Description</B></FONT></TD></TR>
  <TR STYLE="background-color: rgb(204,238,255)">
      <TD STYLE="vertical-align: top; padding-right: 3.2pt"><FONT STYLE="font-size: 10pt">3.1</FONT></TD>
      <TD COLSPAN="2" STYLE="vertical-align: bottom; padding-right: 0; text-align: justify; padding-left: 6pt"><FONT STYLE="font-size: 10pt"><A HREF="http://www.sec.gov/Archives/edgar/data/1448431/000136110608000414/optimizerx_s1-ex0301.htm">Articles of Incorporation of OptimizeRx Corporation (the &ldquo;Company&rdquo;)<SUP>1</SUP></A></FONT></TD></TR>
  <TR STYLE="background-color: White">
      <TD STYLE="vertical-align: top; padding-right: 3.2pt"><FONT STYLE="font-size: 10pt">3.2</FONT></TD>
      <TD COLSPAN="2" STYLE="vertical-align: bottom; padding-right: 0; text-align: justify; padding-left: 6pt"><FONT STYLE="font-size: 10pt"><A HREF="http://www.sec.gov/Archives/edgar/data/1448431/000125529410000605/ex3_1.htm">Amended and Restated Bylaws of the Company<SUP>2</SUP></A></FONT></TD></TR>
  <TR STYLE="background-color: rgb(204,238,255)">
      <TD STYLE="vertical-align: top; padding-right: 3.2pt"><FONT STYLE="font-size: 10pt">3.3</FONT></TD>
      <TD COLSPAN="2" STYLE="vertical-align: bottom; padding-right: 0; text-align: justify; padding-left: 6pt"><FONT STYLE="font-size: 10pt"><A HREF="http://www.sec.gov/Archives/edgar/data/1448431/000136110608000414/optimizerx_s1-ex0301.htm">Certificate of Designation, filed on September 5, 2008 with the Secretary of State of the State of Nevada by the Company<SUP>1</SUP></A></FONT></TD></TR>
  <TR STYLE="background-color: White">
      <TD STYLE="vertical-align: top; padding-right: 3.2pt"><FONT STYLE="font-size: 10pt">3.4</FONT></TD>
      <TD COLSPAN="2" STYLE="vertical-align: bottom; padding-right: 0; text-align: justify; padding-left: 6pt"><FONT STYLE="font-size: 10pt"><A HREF="http://www.sec.gov/Archives/edgar/data/1448431/000125529410000492/ex4_1.htm">Certificate of Designation, filed on June 3, 2010 with the Secretary of State of the State of Nevada by the Company<SUP>3</SUP></A></FONT></TD></TR>
  <TR STYLE="background-color: rgb(204,238,255)">
      <TD STYLE="vertical-align: top; padding-right: 3.2pt"><FONT STYLE="font-size: 10pt">3.5</FONT></TD>
      <TD COLSPAN="2" STYLE="vertical-align: bottom; padding-right: 0; text-align: justify; padding-left: 6pt"><FONT STYLE="font-size: 10pt"><A HREF="http://www.sec.gov/Archives/edgar/data/1448431/000121390019003962/f10k2018ex3-5_optimizerx.htm">Certificate of Correction,&nbsp;&nbsp;dated April 30, 2018<SUP>11</SUP></A></FONT></TD></TR>
  <TR STYLE="background-color: White">
      <TD STYLE="vertical-align: top; padding-right: 3.2pt"><FONT STYLE="font-size: 10pt">3.6</FONT></TD>
      <TD COLSPAN="2" STYLE="vertical-align: bottom; padding-right: 0; text-align: justify; padding-left: 6pt"><FONT STYLE="font-size: 10pt"><A HREF="http://www.sec.gov/Archives/edgar/data/1448431/000121390019003962/f10k2018ex3-6_optimizerx.htm">Certificate of Withdrawal of Certificate of Designation, dated May 10, 2018<SUP>11</SUP></A></FONT></TD></TR>
  <TR STYLE="background-color: rgb(204,238,255)">
      <TD STYLE="vertical-align: top; padding-right: 3.2pt">4.1**</TD>
      <TD COLSPAN="2" STYLE="vertical-align: bottom; padding-right: 0; text-align: justify; padding-left: 6pt"><A HREF="fs82019ex4-1_optimizerx.htm">Third Amended and Restated 2013 Equity Incentive Plan</A></TD></TR>
  <TR STYLE="background-color: White">
      <TD STYLE="vertical-align: top; padding-right: 3.2pt"><FONT STYLE="font-size: 10pt">5.1**</FONT></TD>
      <TD COLSPAN="2" STYLE="vertical-align: bottom; padding-right: 0; text-align: justify; padding-left: 6pt"><FONT STYLE="font-size: 10pt"><A HREF="fs82019ex5-1_optimizerx.htm" STYLE="-sec-extract: exhibit">The Doney Law Firm Opinion and consent to use</A></FONT></TD></TR>
  <TR STYLE="background-color: rgb(204,238,255)">
      <TD STYLE="vertical-align: top; padding-right: 3.2pt"><FONT STYLE="font-size: 10pt">10.1</FONT></TD>
      <TD COLSPAN="2" STYLE="vertical-align: bottom; padding-right: 0; text-align: justify; padding-left: 6pt"><FONT STYLE="font-size: 10pt"><A HREF="http://www.sec.gov/Archives/edgar/data/1448431/000121390016013077/f10q0316ex10i_optimizerx.htm">Separation Agreement, Corporate Consulting Agreement and Confidentiality Agreement between the Company and David Harrell dated May 5, 2016<SUP>4</SUP></A></FONT></TD></TR>
  <TR STYLE="background-color: White">
      <TD STYLE="vertical-align: top; padding-right: 3.2pt"><FONT STYLE="font-size: 10pt">10.2</FONT></TD>
      <TD COLSPAN="2" STYLE="vertical-align: bottom; padding-right: 0; text-align: justify; padding-left: 6pt"><FONT STYLE="font-size: 10pt"><A HREF="http://www.sec.gov/Archives/edgar/data/1448431/000121390018012576/f8k091218ex10-2_optimizerx.htm">Amendment to Employment Agreement with Miriam Paramore, dated September 10, 2018<SUP>5</SUP></A></FONT></TD></TR>
  <TR STYLE="background-color: rgb(204,238,255)">
      <TD STYLE="vertical-align: top; padding-right: 3.2pt"><FONT STYLE="font-size: 10pt">10.3</FONT></TD>
      <TD COLSPAN="2" STYLE="vertical-align: bottom; padding-right: 0; text-align: justify; padding-left: 6pt"><A HREF="http://www.sec.gov/Archives/edgar/data/1448431/000121390018005414/f10q0318ex10-1_optimizerx.htm"><FONT STYLE="font-size: 10pt">Purchase
      Agreement, dated May 2, 2018<SUP>6</SUP></FONT></A></TD></TR>
  <TR STYLE="background-color: White">
      <TD STYLE="vertical-align: top; padding-right: 3.2pt"><FONT STYLE="font-size: 10pt">10.4</FONT></TD>
      <TD COLSPAN="2" STYLE="vertical-align: bottom; padding-right: 0; text-align: justify; padding-left: 6pt"><A HREF="http://www.sec.gov/Archives/edgar/data/1448431/000121390018005414/f10q0318ex10-2_optimizerx.htm"><FONT STYLE="font-size: 10pt">Registration
      Rights Agreement, dated May 2, 2018<SUP>6</SUP></FONT></A></TD></TR>
  <TR STYLE="background-color: rgb(204,238,255)">
      <TD STYLE="vertical-align: top; padding-right: 3.2pt"><FONT STYLE="font-size: 10pt">10.5</FONT></TD>
      <TD COLSPAN="2" STYLE="vertical-align: bottom; padding-right: 0; text-align: justify; padding-left: 6pt"><A HREF="http://www.sec.gov/Archives/edgar/data/1448431/000121390018014013/f8k101718ex2-1_optimizerx.htm"><FONT STYLE="font-size: 10pt">Stock
      Purchase Agreement, dated October 17, 2018<SUP>7</SUP></FONT></A></TD></TR>
  <TR STYLE="background-color: White">
      <TD STYLE="vertical-align: top; padding-right: 3.2pt"><FONT STYLE="font-size: 10pt">10.6</FONT></TD>
      <TD COLSPAN="2" STYLE="vertical-align: bottom; padding-right: 0; text-align: justify; padding-left: 6pt"><A HREF="http://www.sec.gov/Archives/edgar/data/1448431/000121390019001955/f8k020719ex10-1_optimizerx.htm"><FONT STYLE="font-size: 10pt">Amendment to Employment Agreement with Terry Hamilton, dated February 7, 2019<SUP>8</SUP></FONT></A></TD></TR>
  <TR STYLE="background-color: rgb(204,238,255)">
      <TD STYLE="vertical-align: top; padding-right: 3.2pt"><FONT STYLE="font-size: 10pt">10.7</FONT></TD>
      <TD COLSPAN="2" STYLE="vertical-align: bottom; padding-right: 0; text-align: justify; padding-left: 6pt"><A HREF="http://www.sec.gov/Archives/edgar/data/1448431/000121390019001955/f8k020719ex10-2_optimizerx.htm"><FONT STYLE="font-size: 10pt">Amendment to Employment Agreement with Doug Baker, dated February 7, 2019<SUP>8</SUP></FONT></A></TD></TR>
  <TR STYLE="background-color: White">
      <TD STYLE="vertical-align: top; padding-right: 3.2pt"><FONT STYLE="font-size: 10pt">10.8</FONT></TD>
      <TD COLSPAN="2" STYLE="vertical-align: bottom; padding-right: 0; text-align: justify; padding-left: 6pt"><FONT STYLE="font-size: 10pt"><A HREF="http://www.sec.gov/Archives/edgar/data/1448431/000121390019003159/f8k022519ex10-1_optimizerx.htm">Amendment to Employment Agreement with William Febbo, dated February 25, 2019<SUP>9</SUP></A></FONT></TD></TR>
  <TR STYLE="background-color: rgb(204,238,255)">
      <TD STYLE="vertical-align: top; padding-right: 3.2pt"><FONT STYLE="font-size: 10pt">14.1</FONT></TD>
      <TD COLSPAN="2" STYLE="vertical-align: bottom; padding-right: 0; text-align: justify; padding-left: 6pt"><A HREF="http://www.sec.gov/Archives/edgar/data/1448431/000121390018002722/f10k2017ex14-1_optimizerx.htm"><FONT STYLE="font-size: 10pt">Code
  of Business Conduct and Ethics<SUP>10</SUP></FONT></A></TD></TR>
  <TR STYLE="background-color: White">
      <TD STYLE="vertical-align: top; padding-right: 3.2pt">21.1</TD>
      <TD COLSPAN="2" STYLE="vertical-align: bottom; padding-right: 0; text-align: justify; padding-left: 6pt"><A HREF="http://www.sec.gov/Archives/edgar/data/1448431/000121390019003962/f10k2018ex21-1_optimizerx.htm">List of Subsidiarie</A><SUP>11</SUP></TD></TR>
  <TR STYLE="background-color: rgb(204,238,255)">
      <TD STYLE="vertical-align: top; padding-right: 3.2pt"><FONT STYLE="font-size: 10pt">23.1**</FONT></TD>
      <TD COLSPAN="2" STYLE="vertical-align: bottom; padding-right: 0; text-align: justify; padding-left: 6pt"><FONT STYLE="font-size: 10pt"><A HREF="fs82019ex23-1_optimizerx.htm" STYLE="-sec-extract: exhibit">Consent of Sadler, Gibb &amp; Associates, LLC**</A></FONT></TD></TR>
  </TABLE>
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.5in">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.5in"></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.5in">&nbsp;</P>
  
  <TABLE CELLPADDING="0" CELLSPACING="0" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 0; width: 100%"><TR STYLE="vertical-align: top; text-align: justify">
  <TD STYLE="width: 0"></TD><TD STYLE="width: 0.25in; text-align: left"><SUP>1</SUP></TD><TD STYLE="text-align: justify">Incorporated by reference to the Form S-1, filed by the
  Company with the Securities and Exchange Commission on November 12, 2008.</TD>
  </TR></TABLE>
  
  <TABLE CELLPADDING="0" CELLSPACING="0" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 0; width: 100%"><TR STYLE="vertical-align: top; text-align: justify">
  <TD STYLE="width: 0"></TD><TD STYLE="width: 0.25in; text-align: left"><SUP>2</SUP></TD><TD STYLE="text-align: justify">Incorporated by reference to the Form 8-K, filed by the
  Company with the Securities and Exchange Commission on July 16, 2010.</TD>
  </TR></TABLE>
  
  <TABLE CELLPADDING="0" CELLSPACING="0" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 0; width: 100%"><TR STYLE="vertical-align: top; text-align: justify">
  <TD STYLE="width: 0"></TD><TD STYLE="width: 0.25in; text-align: left"><SUP>3</SUP></TD><TD STYLE="text-align: justify">Incorporated by reference to the Form 8-K, filed by the
  Company with the Securities and Exchange Commission on June 11, 2010.</TD>
  </TR></TABLE>
  
  <TABLE CELLPADDING="0" CELLSPACING="0" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 0; width: 100%"><TR STYLE="vertical-align: top; text-align: justify">
  <TD STYLE="width: 0"></TD><TD STYLE="width: 0.25in; text-align: left"><SUP>4</SUP></TD><TD STYLE="text-align: justify">Incorporated by reference to the Form 10-Q, filed by the
  Company with the Securities and Exchange Commission on May 9, 2016.</TD>
  </TR></TABLE>
  
  
  <TABLE CELLPADDING="0" CELLSPACING="0" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 0; width: 100%"><TR STYLE="vertical-align: top; text-align: justify">
  <TD STYLE="width: 0"></TD><TD STYLE="width: 0.25in; text-align: left"><SUP>5</SUP></TD><TD STYLE="text-align: justify">Incorporated by reference to the Form 8-K filed by the
  Company with the Securities and Exchange Commission on September 14, 2018.</TD>
  </TR></TABLE>
  
  <TABLE CELLPADDING="0" CELLSPACING="0" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 0; width: 100%"><TR STYLE="vertical-align: top; text-align: justify">
  <TD STYLE="width: 0"></TD><TD STYLE="width: 0.25in; text-align: left"><SUP>6</SUP></TD><TD STYLE="text-align: justify">Incorporated by reference to the Form 10-Q filed by the
  Company with the Securities and Exchange Commission on May 2, 2018.</TD>
  </TR></TABLE>
  
  <TABLE CELLPADDING="0" CELLSPACING="0" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 0; width: 100%"><TR STYLE="vertical-align: top; text-align: justify">
  <TD STYLE="width: 0"></TD><TD STYLE="width: 0.25in; text-align: left"><SUP>7</SUP></TD><TD STYLE="text-align: justify">Incorporated by reference to the Form 8-K filed by the
  Company with the Securities and Exchange Commission on October 17, 2018.</TD>
  </TR></TABLE>
  
  <TABLE CELLPADDING="0" CELLSPACING="0" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 0; width: 100%"><TR STYLE="vertical-align: top; text-align: justify">
  <TD STYLE="width: 0"></TD><TD STYLE="width: 0.25in; text-align: left"><SUP>8</SUP></TD><TD STYLE="text-align: justify">Incorporated by reference to the Form 8-K filed by the
  Company with the Securities and Exchange Commission on February 7, 2019.</TD>
  </TR></TABLE>
  
  <TABLE CELLPADDING="0" CELLSPACING="0" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 0; width: 100%"><TR STYLE="vertical-align: top; text-align: justify">
  <TD STYLE="width: 0"></TD><TD STYLE="width: 0.25in; text-align: left"><SUP>9</SUP></TD><TD STYLE="text-align: justify">Incorporated by reference to the Form 8-K filed by the
  Company with the Securities and Exchange Commission on February 26, 2019.</TD>
  </TR></TABLE>
  
  <TABLE CELLPADDING="0" CELLSPACING="0" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 0; width: 100%"><TR STYLE="vertical-align: top; text-align: justify">
  <TD STYLE="width: 0"></TD><TD STYLE="width: 0.25in; text-align: left"><SUP>10</SUP></TD><TD STYLE="text-align: justify">Incorporated by reference to the Form 10-K filed by the
  Company with the Securities and Exchange Commission on March 8, 2018.</TD>
  </TR></TABLE>
  
  <TABLE CELLPADDING="0" CELLSPACING="0" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 0; width: 100%"><TR STYLE="vertical-align: top; text-align: justify">
  <TD STYLE="width: 0"></TD><TD STYLE="width: 0.25in; text-align: left"><SUP>11</SUP></TD><TD STYLE="text-align: justify">Incorporated by reference to the Form 10-K filed by the
  Company with the Securities and Exchange Commission on March 12, 2019.</TD>
  </TR></TABLE>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">** provided herewith</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B>&nbsp;</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B></B></P>
  
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  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B>&nbsp;</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><B><A NAME="a_009"></A>Item 9. Undertakings</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in; text-align: justify">The undersigned registrant hereby undertakes:</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in; text-align: justify">(1) To file, during any period in which
  offers or sales are being made, a post-effective amendment to this registration statement to:</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">(i) include any Prospectus required by Section 10(a)(3) of the
  Securities Act of 1933, as amended;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">(ii) reflect in the Prospectus any facts or events arising after
  the effective date of the registration statement (or the most recent post-effective amendment thereof) which, individually or in
  the aggregate, represent a fundamental change in the information set forth in the registration statement. Notwithstanding the foregoing,
  any increase or decrease in volume of securities offered (if the total dollar value of securities offered would not exceed that
  which was registered) and any deviation from the low or high end of the estimated maximum offering range may be reflected in the
  form of Prospectus filed with the Securities and Exchange Commission pursuant to Rule 424(b) if, in the aggregate, the changes
  in volume and price represent no more than a 20% change in the maximum aggregate offering price set forth in the &ldquo;Calculation
  of Registration Fee&rdquo; table in the effective registration statement; and</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">(iii) include any material information with respect to the plan
  of distribution not previously disclosed in the registration statement or any material change to such information in the registration
  statement;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in; text-align: justify">(2) That, for the purpose of determining
  any liability under the Securities Act of 1933, as amended, each such post-effective amendment shall be deemed to be a new registration
  statement relating to the securities offered therein, and the offering of such securities at that time shall be deemed to be the
  initial bona fide offering thereof.</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in; text-align: justify">(3) To remove from registration by means
  of a post-effective amendment any of the securities being registered which remain unsold at the termination of the offering.</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in; text-align: justify">(4) For purposes of determining liability
  under the Securities Act of 1933 to any purchaser:</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">(i) If the Registrant is subject to Rule 430C, each Prospectus
  filed pursuant to Rule 424(b) as part of a registration statement relating to an offering, other than registration statements relying
  on Rule 430B or other than Prospectuses filed in reliance on Rule 430A, shall be deemed to be part of and included in the registration
  statement as of the date it is first used after effectiveness. Provided, however, that no statement made in a registration statement
  or Prospectus that is part of the registration or made in a document incorporated or deemed incorporated by reference into the
  registration statement or Prospectus that is part of the registration statement will, as to a purchaser with a time of contract
  of sale prior to such first use, supersede or modify any statement that was made in the registration statement or Prospectus that
  was part of the registration statement or made in any such document immediately prior to such date of first use.</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in; text-align: justify">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in; text-align: justify">(5) That for the purpose of determining
  liability of the registrant under the Securities Act of 1933 to any purchaser in the initial distribution of the securities:</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in; text-align: justify">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in; text-align: justify">The undersigned registrant undertakes that
  in a primary offering of securities of the undersigned registrant pursuant to this registration statement, regardless of the underwriting
  method used to sell the securities to the purchaser, if the securities are offered or sold to such purchaser by means of any of
  the following communications, the undersigned registrant will be a seller to the purchaser and will be considered to offer or sell
  such securities to such purchaser:</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">(i) Any preliminary Prospectus or Prospectus of the undersigned
  registrant relating to the offering required to be filed pursuant to Rule 424;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">(ii) Any free writing Prospectus relating to the offering prepared
  by or on behalf of the undersigned registrant or used or referred to by the undersigned registrant;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">(iii) The portion of any other free writing Prospectus relating
  to the offering containing material information about the undersigned registrant or its securities provided by or on behalf of
  the undersigned registrant; and</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">(iv) Any other communication that is an offer in the offering
  made by the undersigned registrant to the purchaser.</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in; text-align: justify">Insofar as indemnification for liabilities
  arising under the Securities Act of 1933 may be permitted to directors, officers and controlling persons of the registrant pursuant
  to the provisions described under Item 24 above, or otherwise, the registrant has been advised that in the opinion of the Securities
  and Exchange Commission such indemnification is against public policy as expressed in the Securities Act of 1933 and is, therefore,
  unenforceable. In the event that a claim for indemnification against such liabilities (other than the payment by the registrant
  of expenses incurred or paid by a director, officer or controlling person of the registrant in the successful defense of any action,
  suit or proceeding) is asserted by such director, officer or controlling person in connection with the securities being registered,
  the registrant will, unless in the opinion of its counsel the matter has been settled by controlling precedent, submit to a court
  of appropriate jurisdiction the question whether such indemnification by it is against public policy as expressed in the Securities
  Act of 1933 and will be governed by the final adjudication of such issue.</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&nbsp;</P>
  
  
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  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center"><B><A NAME="a_010"></A>SIGNATURES</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.5in">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.5in">In accordance with
  the requirements of the Securities Act of 1933, the registrant certifies that it has reasonable grounds to believe that it meets
  all of the requirements to a filing on Form S-8 and authorized this filing to be signed on its behalf by the undersigned, thereunto
  duly authorized, in the City of Rochester, Michigan on March 12, 2019.</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
  
  <TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%">
  <TR STYLE="vertical-align: top">
      <TD>&nbsp;</TD>
      <TD COLSPAN="2"><FONT STYLE="font-size: 10pt"><B>OPTIMIZERX CORPORATION</B></FONT></TD></TR>
  <TR STYLE="vertical-align: top">
      <TD STYLE="width: 60%">&nbsp;</TD>
      <TD STYLE="width: 4%">&nbsp;</TD>
      <TD STYLE="width: 36%">&nbsp;</TD></TR>
  <TR STYLE="vertical-align: top">
      <TD>&nbsp;</TD>
      <TD><FONT STYLE="font-size: 10pt">By:</FONT></TD>
      <TD STYLE="border-bottom: Black 1.5pt solid"><FONT STYLE="font-size: 10pt">/s/&nbsp;William Febbo</FONT></TD></TR>
  <TR>
      <TD STYLE="vertical-align: top">&nbsp;</TD>
      <TD STYLE="vertical-align: top">&nbsp;</TD>
      <TD STYLE="vertical-align: bottom"><FONT STYLE="font-size: 10pt">William Febbo</FONT></TD></TR>
  <TR STYLE="vertical-align: top">
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD><FONT STYLE="font-size: 10pt">Chief Executive Officer (Principal Executive Officer) and Director</FONT></TD></TR>
  <TR STYLE="vertical-align: top">
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD></TR>
  <TR STYLE="vertical-align: top">
      <TD>&nbsp;</TD>
      <TD><FONT STYLE="font-size: 10pt">By:</FONT></TD>
      <TD STYLE="border-bottom: Black 1.5pt solid"><FONT STYLE="font-size: 10pt">/s/&nbsp;Doug Baker</FONT></TD></TR>
  <TR STYLE="vertical-align: top">
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD><FONT STYLE="font-size: 10pt">Doug Baker</FONT></TD></TR>
  <TR STYLE="vertical-align: top">
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD><FONT STYLE="font-size: 10pt">Chief Financial Officer (Principal Financial and Accounting Officer) </FONT></TD></TR>
  </TABLE>
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; background-color: white">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center; background-color: white"><B>POWER OF ATTORNEY</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; background-color: white">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.5in; background-color: white">KNOW
  ALL MEN BY THESE PRESENTS, that the undersigned officers and directors of the Company, hereby constitute and appoint William Febbo
  and Doug Baker and each of them, the true and lawful agents and attorneys-in-fact of the undersigned with full power and authority
  in said agents and attorneys-in-fact, and in any one or more of them, to sign for the undersigned and in their respective names
  as an officer/director of the Company, a registration statement on Form S-8 (or other appropriate form) relating to the offer and
  sale of common stock of the Company pursuant to the Plans (or any and all amendments, including post-effective amendments, to such
  registration statement) and file the same, with all exhibits thereto and other documents in connection therewith, with the Securities
  and Exchange Commission, and with full power of substitution; hereby ratifying and confirming all that each of said attorneys-in-fact,
  or his substitute or substitutes, may do or cause to be done by virtue hereof.</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.25in; background-color: white">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.5in; background-color: white">Pursuant
  to the requirements of the Securities Act of 1933, as amended, this Registration Statement has been signed by the following persons
  in the capacities and on the dates indicated.</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; background-color: white">&nbsp;</P>
  
  <TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
  <TR STYLE="vertical-align: top">
      <TD STYLE="width: 30%; border-bottom: Black 1.5pt solid"><FONT STYLE="font-size: 10pt">/s/ William Febbo</FONT></TD>
      <TD STYLE="width: 1%">&nbsp;</TD>
      <TD><FONT STYLE="font-size: 10pt">Chief Executive Officer</FONT></TD>
      <TD STYLE="width: 1%">&nbsp;</TD>
      <TD STYLE="width: 21%"><FONT STYLE="font-size: 10pt">March 12, 2019</FONT></TD></TR>
  <TR STYLE="vertical-align: top">
      <TD><FONT STYLE="font-size: 10pt">William Febbo</FONT></TD>
      <TD>&nbsp;</TD>
      <TD><FONT STYLE="font-size: 10pt">(Principal Executive Officer) and Director</FONT></TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD></TR>
  <TR STYLE="vertical-align: top">
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD></TR>
  <TR STYLE="vertical-align: top">
      <TD STYLE="border-bottom: Black 1.5pt solid"><FONT STYLE="font-size: 10pt">/s/ Doug Baker</FONT></TD>
      <TD>&nbsp;</TD>
      <TD><FONT STYLE="font-size: 10pt">Chief Financial Officer</FONT></TD>
      <TD>&nbsp;</TD>
      <TD><FONT STYLE="font-size: 10pt">March 12, 2019</FONT></TD></TR>
  <TR STYLE="vertical-align: top">
      <TD><FONT STYLE="font-size: 10pt">Doug Baker</FONT></TD>
      <TD>&nbsp;</TD>
      <TD><FONT STYLE="font-size: 10pt">(Principal Financial and Accounting Officer)</FONT></TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD></TR>
  <TR STYLE="vertical-align: top">
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD></TR>
  <TR STYLE="vertical-align: top">
      <TD STYLE="border-bottom: Black 1.5pt solid"><FONT STYLE="font-size: 10pt">/s/ Lynn Vos</FONT></TD>
      <TD>&nbsp;</TD>
      <TD><FONT STYLE="font-size: 10pt">Director</FONT></TD>
      <TD>&nbsp;</TD>
      <TD><FONT STYLE="font-size: 10pt">March 12, 2019</FONT></TD></TR>
  <TR STYLE="vertical-align: top">
      <TD><FONT STYLE="font-size: 10pt">Lynn Vos</FONT></TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD></TR>
  <TR STYLE="vertical-align: top">
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD></TR>
  <TR STYLE="vertical-align: top">
      <TD STYLE="border-bottom: Black 1.5pt solid"><FONT STYLE="font-size: 10pt">/s/ Patrick Spangler</FONT></TD>
      <TD>&nbsp;</TD>
      <TD><FONT STYLE="font-size: 10pt">Director</FONT></TD>
      <TD>&nbsp;</TD>
      <TD><FONT STYLE="font-size: 10pt">March 12, 2019</FONT></TD></TR>
  <TR STYLE="vertical-align: top">
      <TD><FONT STYLE="font-size: 10pt">Patrick Spangler</FONT></TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD></TR>
  <TR STYLE="vertical-align: top">
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD></TR>
  <TR STYLE="vertical-align: top">
      <TD STYLE="border-bottom: Black 1.5pt solid"><FONT STYLE="font-size: 10pt">/s/ James Lang</FONT></TD>
      <TD>&nbsp;</TD>
      <TD><FONT STYLE="font-size: 10pt">Director</FONT></TD>
      <TD>&nbsp;</TD>
      <TD><FONT STYLE="font-size: 10pt">March 12, 2019</FONT></TD></TR>
  <TR STYLE="vertical-align: top">
      <TD><FONT STYLE="font-size: 10pt">James Lang</FONT></TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD></TR>
  <TR STYLE="vertical-align: top">
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD></TR>
  <TR STYLE="vertical-align: top">
      <TD STYLE="border-bottom: Black 1.5pt solid"><FONT STYLE="font-size: 10pt">/s/ Gus D. Halas</FONT></TD>
      <TD>&nbsp;</TD>
      <TD><FONT STYLE="font-size: 10pt">Director</FONT></TD>
      <TD>&nbsp;</TD>
      <TD><FONT STYLE="font-size: 10pt">March 12, 2019</FONT></TD></TR>
  <TR STYLE="vertical-align: top">
      <TD><FONT STYLE="font-size: 10pt">Gus D. Halas</FONT></TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD></TR>
  </TABLE>
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; text-align: left; margin-bottom: 0pt">&nbsp;</P>
  
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  </HTML>
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metadata_filer: {"company-data": {"conformed-name": "OptimizeRx Corp", "cik": "0001448431", "assigned-sic": "7389", "irs-number": "261265381", "state-of-incorporation": "NV", "fiscal-year-end": "1231"}, "filing-values": {"form-type": "S-8", "act": "33", "file-number": "333-230212", "film-number": "19676630"}, "business-address": {"street1": "400 WATER ST., STE. 200", "city": "ROCHESTER", "state": "MI", "zip": "48307", "phone": "248-651-6558"}, "mail-address": {"street1": "400 WATER ST., STE. 200", "city": "ROCHESTER", "state": "MI", "zip": "48307"}}
text: UNITED STATES
  SECURITIES AND EXCHANGE COMMISSION
  WASHINGTON, D.C. 20549
  FORM S-8
  REGISTRATION STATEMENT
  UNDER THE SECURITIES ACT OF 1933
  OptimizeRx Corp.
  (Exact name of registrant as specified in
  its charter)
  Nevada
  26-1265381
  (State or other jurisdiction of
  incorporation or organization)
  (I.R.S. Employer
  Identification No.)
  400 Water Street, Suite 200,
  Rochester, MI 48307
  (Address of Principal Executive Offices)
  Amended and Restated OptimizeRx Corp.
  2013 Incentive Plan
  (Full title of the plan)
  Spring Valley Solutions, LLC
  4955 S. Durango Rd. Ste. 165
  Las Vegas, NV 89113
  (Name and address of agent for service)
  (248) 651-6568
  (Telephone number, including area Code,
  of agent for service)
  Indicate by check mark whether the Registrant is a large accelerated
  filer, an accelerated filer, a non-accelerated filer, a smaller reporting company or an emerging growth company. See the definitions
  of "large accelerated filer," "accelerated filer," "smaller reporting company" and "emerging
  growth company" in Rule 12b-2 of the Exchange Act.
  Large accelerated filer:
  ☐
  Accelerated filer:
  ☒
  Non-accelerated filer:
  ☐
  Smaller reporting company:
  ☒
  Emerging growth company:
  ☐
  If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 7(a)(2)(B) of the Securities Act.
  ☐
  Calculation
  of Registration Fee
  Title of each class of securities to be registered
  Amount
  to be
  registered
  (1)
  Proposed
  maximum
  offering
  price
  per share
  (2)
  Proposed
  maximum
  aggregate
  offering
  price
  Amount of
  registration
  fee
  Common Stock $0.001 par value
  1,116,666
  $
  14.72
  $
  16,437,323.52
  $
  1,992.20
  (1)
  An aggregate of 1,116,666 shares of Common Stock may be
  offered or issued pursuant to the Amended and Restated 2013 OptimizeRx Corp. 2015 Equity Incentive Plan (the "Plan").
  In addition, pursuant to Rule 416(c) under the Securities Act of 1933, as amended (the "Securities Act"), this Registration
  Statement also covers an indeterminate number of shares of Common Stock that may be offered or issued by reason of stock splits,
  stock dividends or similar transactions that become issuable under the Plan.
  (2)
  Estimated in accordance with
  Rule 457(c) promulgated under the Securities Act solely for the purpose of calculating the amount of the registration fee on the
  basis of the average of the high and low price per share of the Registrant's Common Stock as reported on the Nasdaq Capital
  Market on March 8, 2019.
  This registration statement shall become effective upon filing
  in accordance with Rule 462 under the Securities Act.
  Table
  of Contents
  PART I
  1
  PART II
  2
  Item 3. Incorporation of Documents by Reference.
  2
  Item 4. Description of Securities.
  3
  Item 5. Interests of Named Experts and Counsel.
  3
  Item 6. Indemnification of Directors and Officers.
  3
  Item 7. Exemption from Registration Claimed.
  4
  Item 8. Exhibits.
  5
  Item 9. Undertakings.
  6
  Signatures
  7
  i
  Table of Contents
  PART I
  Information
  Required in the Section 10(A) Prospectus
  The documents containing the information
  specified in Part I will be sent or given to participants in the Plan as specified by Rule 428(b)(1) of the Securities Act of 1933,
  as amended (the "Securities Act"). In accordance with the instructions of Part I of Form S-8, these documents will
  not be filed with the Securities and Exchange Commission (the "SEC") either as part of this Registration Statement
  or as prospectuses or prospectus supplements pursuant to Rule 424 of the Securities Act. These documents and the documents incorporated
  by reference pursuant to Item 3 of Part II of this Registration Statement, taken together, constitute the prospectus as required
  by Section 10(a) of the Securities Act.
  All requests should be directed to:
  OptimizeRx Corp.
  400 Water Street, Suite 200,
  Rochester, MI 48307
  Attention: Douglas Baker
  Chief Financial Officer
  Or by calling: (
  248) 651-6568
  1
  Table of Contents
  PART II
  Information
  Required in the Registration Statement
  Item 3. Incorporation of Documents
  by Reference
  .
  The SEC allows us to "incorporate
  by reference" the information we file with the SEC. This permits us to disclose important information to you by referring
  to these filed documents. Any information referred to in this way is considered part of this prospectus supplement. The information
  incorporated by reference is an important part of this prospectus supplement and the accompanying prospectus, and information that
  we file later with the SEC will automatically update and supersede this information. We incorporate by reference the following
  documents that have been filed with the SEC (other than information furnished under Item 2.02, Item 7.01 of Item 8.01 of Form 8-K
  and all exhibits related to such items):
  ●
  Our Annual Report on Form 10-K for the fiscal year ended
  December 31, 2018, filed with the SEC on March 12, 2019;
  ●
  Current Reports on Form 8-K or 8-K/A, as the case
  may be, filed with the SEC on February 26, 2019, February 8, 2019, December 21, 2018, December 10, 2018, October 17, 2018, September
  14, 2018, March 27, 2018 and February 2, 2018; and
  ●
  The description of our common stock in our Registration
  Statement on Form S-3/A, filed with the SEC on December 11, 2018, including any amendment or reports filed for the purpose of
  updating such description.
  In addition, all other documents filed (not
  furnished) by us pursuant to Section 13(a), Section 13(c), Section 14 or Section 15(d) of the Exchange Act on or after the date
  of this reoffer prospectus and prior to the termination of this offering, shall be deemed to be incorporated by reference into
  this reoffer prospectus and to be a part of this reoffer prospectus from the date of the filing of such documents; provided, however,
  that documents or information deemed to have been furnished to and not filed with the SEC in accordance with the rules of the SEC
  shall not be deemed incorporated by reference into this reoffer prospectus.
  Any information in any of the foregoing
  documents will automatically be deemed to be modified or superseded to the extent that information in this prospectus supplement
  and the accompanying prospectus or in a later filed document that is incorporated or deemed to be incorporated herein by reference
  modifies or replaces such information.
  You may request, orally or in writing, a
  copy of these documents, which will be provided to you at no cost (other than exhibits, unless such exhibits are specifically incorporate
  by reference), by contacting Douglas Baker, c/o OptimizeRx Corporation., at 400 Water Street, Suite 200, Rochester, MI 48307. Our
  telephone number is (248) 651-6568.
  2
  Table of Contents
  Item 4. Description of Securities.
  Not Applicable.
  Item 5. Interests of Named Experts and
  Counsel.
  No expert or counsel named in this prospectus
  as having prepared or certified any part of it or as having given an opinion upon the validity of the securities being registered
  or upon other legal matters in connection with the registration or offering of the common stock was employed on a contingency basis,
  or had, or is to receive, in connection with the offering, a substantial interest, direct or indirect, in the Company or any of
  its parents or subsidiaries. Nor was any such person connected with the Company or any of its parents or subsidiaries as a promoter,
  managing or principal underwriter, voting trustee, director, officer, or employee.
  Item 6. Indemnification of Directors and
  Officers.
  The statutes, charter provisions, bylaws,
  contracts or other arrangements under which controlling persons, directors or officers of the registrant are insured or indemnified
  in any manner against any liability which they may incur in such capacity are as follows:
  Section 78.751 of the Nevada Revised Statutes
  provides that each corporation shall have the following powers regarding indemnification:
  1) A corporation may indemnify any person
  who was or is a party or is threatened to be made a party to any threatened, pending or completed action, suit or proceeding, whether
  civil, criminal, administrative or investigative, except an action by or in the right of the corporation, by reason of the fact
  that he is or was a director, officer, employee or agent of the corporation, or is or was serving at the request of the corporation
  as a director, officer, employee or agent of another corporation, partnership, joint venture, trust or other enterprise, against
  expenses, including attorneys' fees, judgments, fines and amounts paid in settlement actually and reasonably incurred by him in
  connection with the action, suit or proceeding if he acted in good faith and in a manner which he reasonably believed to be in
  or not opposed to the best interest of the corporation, and, with respect to any criminal action or proceeding, had no reasonable
  cause to believe his conduct was unlawful. The termination of any action, suit or proceeding by judgment, order, settlement, conviction,
  or upon a plea of nolo contendere or its equivalent, does not, of itself create a presumption that the person did not act in good
  faith and in a manner which he reasonably believed to be in or not opposed to the best interests of the corporation, and that,
  with respect to any criminal action or proceeding, he had reasonable cause to believe that his conduct was unlawful.
  2) A corporation may indemnify any person
  who was or is a party or is threatened to be made a party to any threatened, pending or completed action or suit by or in the right
  of the corporation to procure a judgment in its favor by reason of the fact that he is or was a director, officer, employee or
  agent of the corporation, or is or was serving at the request of the corporation as a director, officer, employee or agent of another
  corporation, partnership, joint venture, trust or other enterprise against expenses, including amounts paid in settlement and attorneys'
  fees actually and reasonably incurred by him in connection with the defense or settlement of the action or suit if he acted in
  good faith and in a manner which he reasonably believed to be in or not opposed to the best interests of the corporation. Indemnification
  may not be made for any claim, issue or matter as to which such a person has been adjudged by a court of competent jurisdiction,
  after exhaustion of all appeals there from, to be liable to the corporation or for amounts paid in settlement to the corporation,
  unless and only to the extent that the court in which the action or suit was brought or other court of competent jurisdiction,
  determines upon application that in view of all the circumstances of the case, the person is fairly and reasonably entitled to
  indemnity such expenses as the court deems proper.
  3
  Table of Contents
  3) To the extent that a director, officer,
  employee or agent of a corporation has been successful on the merits or otherwise in defense of any action, suit or proceeding
  referred to in subsections 1 and 2, or in defense of any claim, issue or matter therein, he must be indemnified by the corporation
  against expenses, including attorneys' fees, actually and reasonably incurred by him in connection with the defense.
  4) Any indemnification under subsections
  1 and 2, unless ordered by a court or advanced pursuant to subsection 5, must be made by the corporation only as authorized in
  the specific case upon a determination that indemnification of the director, officer, employee or agent is proper in the circumstances.
  The determination must be made:
  a) By the stockholders;
  b) By the board of directors by majority
  vote of a quorum consisting of directors who were not parties to the act, suit or proceeding;
  c) If a majority vote of a quorum consisting
  of directors who were not parties to the act, suit or proceeding so orders, by independent legal counsel, in a written opinion;
  or if a quorum consisting of directors who were not parties to the act, suit or proceeding cannot be obtained, by independent legal
  counsel in a written opinion.
  d) The certificate or articles of incorporation,
  the bylaws or an agreement made by the corporation may provide that the expenses of officers and directors incurred in defending
  a civil or criminal action, suit or proceeding must be paid by the corporation as they are incurred and in advance of the final
  disposition of the action, suit or proceeding, upon receipt of an undertaking by or on behalf of the director or officer to repay
  the amount if it is ultimately determined by a court of competent jurisdiction that he is not entitled to be indemnified by the
  corporation. The provisions of this subsection do not affect any rights to advancement of expenses to which corporate personnel
  other than directors or officers may be entitled under any contract or otherwise by law.
  5) The indemnification and advancement of
  expenses authorized in or ordered by a court pursuant to this section:
  a) Does not exclude any other rights to
  which a person seeking indemnification or advancement of expenses may be entitled under the certificate or articles of incorporation
  or any bylaw, agreement, vote of stockholders of disinterested directors or otherwise, for either an action in his official capacity
  or an action in another capacity while holding his office, except that indemnification, unless ordered by a court pursuant to subsection
  2 or for the advancement of expenses made pursuant to subsection 5, may not be made to or on behalf of any director or officer
  if a final adjudication establishes that his acts or omissions involved intentional misconduct, fraud or a knowing violation of
  the law and was material to the cause of action.
  b) Continues for a person who has ceased
  to be a director, officer, employee or agent and inures to the benefit of the heirs, executors and administrators of such a person.
  Article VI of our Amended and Restated Bylaws
  also provides specific indemnification provisions for our officers, directors, employees and or agents to the fullest extent of
  the law.
  Item 7. Exemption from Registration Claimed.
  Not applicable.
  4
  Table of Contents
  Item 8. Exhibits.
  Exhibit Number
  Description
  3.1
  Articles of Incorporation of OptimizeRx Corporation (the "Company")
  1
  3.2
  Amended and Restated Bylaws of the Company
  2
  3.3
  Certificate of Designation, filed on September 5, 2008 with the Secretary of State of the State of Nevada by the Company
  1
  3.4
  Certificate of Designation, filed on June 3, 2010 with the Secretary of State of the State of Nevada by the Company
  3
  3.5
  Certificate of Correction,  dated April 30, 2018
  11
  3.6
  Certificate of Withdrawal of Certificate of Designation, dated May 10, 2018
  11
  4.1**
  Third Amended and Restated 2013 Equity Incentive Plan
  5.1**
  The Doney Law Firm Opinion and consent to use
  10.1
  Separation Agreement, Corporate Consulting Agreement and Confidentiality Agreement between the Company and David Harrell dated May 5, 2016
  4
  10.2
  Amendment to Employment Agreement with Miriam Paramore, dated September 10, 2018
  5
  10.3
  Purchase
      Agreement, dated May 2, 2018
  6
  10.4
  Registration
      Rights Agreement, dated May 2, 2018
  6
  10.5
  Stock
      Purchase Agreement, dated October 17, 2018
  7
  10.6
  Amendment to Employment Agreement with Terry Hamilton, dated February 7, 2019
  8
  10.7
  Amendment to Employment Agreement with Doug Baker, dated February 7, 2019
  8
  10.8
  Amendment to Employment Agreement with William Febbo, dated February 25, 2019
  9
  14.1
  Code
  of Business Conduct and Ethics
  10
  21.1
  List of Subsidiarie
  11
  23.1**
  Consent of Sadler, Gibb & Associates, LLC**
  1
  Incorporated by reference to the Form S-1, filed by the
  Company with the Securities and Exchange Commission on November 12, 2008.
  2
  Incorporated by reference to the Form 8-K, filed by the
  Company with the Securities and Exchange Commission on July 16, 2010.
  3
  Incorporated by reference to the Form 8-K, filed by the
  Company with the Securities and Exchange Commission on June 11, 2010.
  4
  Incorporated by reference to the Form 10-Q, filed by the
  Company with the Securities and Exchange Commission on May 9, 2016.
  5
  Incorporated by reference to the Form 8-K filed by the
  Company with the Securities and Exchange Commission on September 14, 2018.
  6
  Incorporated by reference to the Form 10-Q filed by the
  Company with the Securities and Exchange Commission on May 2, 2018.
  7
  Incorporated by reference to the Form 8-K filed by the
  Company with the Securities and Exchange Commission on October 17, 2018.
  8
  Incorporated by reference to the Form 8-K filed by the
  Company with the Securities and Exchange Commission on February 7, 2019.
  9
  Incorporated by reference to the Form 8-K filed by the
  Company with the Securities and Exchange Commission on February 26, 2019.
  10
  Incorporated by reference to the Form 10-K filed by the
  Company with the Securities and Exchange Commission on March 8, 2018.
  11
  Incorporated by reference to the Form 10-K filed by the
  Company with the Securities and Exchange Commission on March 12, 2019.
  ** provided herewith
  5
  Table of Contents
  Item 9. Undertakings
  The undersigned registrant hereby undertakes:
  (1) To file, during any period in which
  offers or sales are being made, a post-effective amendment to this registration statement to:
  (i) include any Prospectus required by Section 10(a)(3) of the
  Securities Act of 1933, as amended;
  (ii) reflect in the Prospectus any facts or events arising after
  the effective date of the registration statement (or the most recent post-effective amendment thereof) which, individually or in
  the aggregate, represent a fundamental change in the information set forth in the registration statement. Notwithstanding the foregoing,
  any increase or decrease in volume of securities offered (if the total dollar value of securities offered would not exceed that
  which was registered) and any deviation from the low or high end of the estimated maximum offering range may be reflected in the
  form of Prospectus filed with the Securities and Exchange Commission pursuant to Rule 424(b) if, in the aggregate, the changes
  in volume and price represent no more than a 20% change in the maximum aggregate offering price set forth in the "Calculation
  of Registration Fee" table in the effective registration statement; and
  (iii) include any material information with respect to the plan
  of distribution not previously disclosed in the registration statement or any material change to such information in the registration
  statement;
  (2) That, for the purpose of determining
  any liability under the Securities Act of 1933, as amended, each such post-effective amendment shall be deemed to be a new registration
  statement relating to the securities offered therein, and the offering of such securities at that time shall be deemed to be the
  initial bona fide offering thereof.
  (3) To remove from registration by means
  of a post-effective amendment any of the securities being registered which remain unsold at the termination of the offering.
  (4) For purposes of determining liability
  under the Securities Act of 1933 to any purchaser:
  (i) If the Registrant is subject to Rule 430C, each Prospectus
  filed pursuant to Rule 424(b) as part of a registration statement relating to an offering, other than registration statements relying
  on Rule 430B or other than Prospectuses filed in reliance on Rule 430A, shall be deemed to be part of and included in the registration
  statement as of the date it is first used after effectiveness. Provided, however, that no statement made in a registration statement
  or Prospectus that is part of the registration or made in a document incorporated or deemed incorporated by reference into the
  registration statement or Prospectus that is part of the registration statement will, as to a purchaser with a time of contract
  of sale prior to such first use, supersede or modify any statement that was made in the registration statement or Prospectus that
  was part of the registration statement or made in any such document immediately prior to such date of first use.
  (5) That for the purpose of determining
  liability of the registrant under the Securities Act of 1933 to any purchaser in the initial distribution of the securities:
  The undersigned registrant undertakes that
  in a primary offering of securities of the undersigned registrant pursuant to this registration statement, regardless of the underwriting
  method used to sell the securities to the purchaser, if the securities are offered or sold to such purchaser by means of any of
  the following communications, the undersigned registrant will be a seller to the purchaser and will be considered to offer or sell
  such securities to such purchaser:
  (i) Any preliminary Prospectus or Prospectus of the undersigned
  registrant relating to the offering required to be filed pursuant to Rule 424;
  (ii) Any free writing Prospectus relating to the offering prepared
  by or on behalf of the undersigned registrant or used or referred to by the undersigned registrant;
  (iii) The portion of any other free writing Prospectus relating
  to the offering containing material information about the undersigned registrant or its securities provided by or on behalf of
  the undersigned registrant; and
  (iv) Any other communication that is an offer in the offering
  made by the undersigned registrant to the purchaser.
  Insofar as indemnification for liabilities
  arising under the Securities Act of 1933 may be permitted to directors, officers and controlling persons of the registrant pursuant
  to the provisions described under Item 24 above, or otherwise, the registrant has been advised that in the opinion of the Securities
  and Exchange Commission such indemnification is against public policy as expressed in the Securities Act of 1933 and is, therefore,
  unenforceable. In the event that a claim for indemnification against such liabilities (other than the payment by the registrant
  of expenses incurred or paid by a director, officer or controlling person of the registrant in the successful defense of any action,
  suit or proceeding) is asserted by such director, officer or controlling person in connection with the securities being registered,
  the registrant will, unless in the opinion of its counsel the matter has been settled by controlling precedent, submit to a court
  of appropriate jurisdiction the question whether such indemnification by it is against public policy as expressed in the Securities
  Act of 1933 and will be governed by the final adjudication of such issue.
  6
  Table of Contents
  SIGNATURES
  In accordance with
  the requirements of the Securities Act of 1933, the registrant certifies that it has reasonable grounds to believe that it meets
  all of the requirements to a filing on Form S-8 and authorized this filing to be signed on its behalf by the undersigned, thereunto
  duly authorized, in the City of Rochester, Michigan on March 12, 2019.
  OPTIMIZERX CORPORATION
  By:
  /s/ William Febbo
  William Febbo
  Chief Executive Officer (Principal Executive Officer) and Director
  By:
  /s/ Doug Baker
  Doug Baker
  Chief Financial Officer (Principal Financial and Accounting Officer)
  POWER OF ATTORNEY
  KNOW
  ALL MEN BY THESE PRESENTS, that the undersigned officers and directors of the Company, hereby constitute and appoint William Febbo
  and Doug Baker and each of them, the true and lawful agents and attorneys-in-fact of the undersigned with full power and authority
  in said agents and attorneys-in-fact, and in any one or more of them, to sign for the undersigned and in their respective names
  as an officer/director of the Company, a registration statement on Form S-8 (or other appropriate form) relating to the offer and
  sale of common stock of the Company pursuant to the Plans (or any and all amendments, including post-effective amendments, to such
  registration statement) and file the same, with all exhibits thereto and other documents in connection therewith, with the Securities
  and Exchange Commission, and with full power of substitution; hereby ratifying and confirming all that each of said attorneys-in-fact,
  or his substitute or substitutes, may do or cause to be done by virtue hereof.
  Pursuant
  to the requirements of the Securities Act of 1933, as amended, this Registration Statement has been signed by the following persons
  in the capacities and on the dates indicated.
  /s/ William Febbo
  Chief Executive Officer
  March 12, 2019
  William Febbo
  (Principal Executive Officer) and Director
  /s/ Doug Baker
  Chief Financial Officer
  March 12, 2019
  Doug Baker
  (Principal Financial and Accounting Officer)
  /s/ Lynn Vos
  Director
  March 12, 2019
  Lynn Vos
  /s/ Patrick Spangler
  Director
  March 12, 2019
  Patrick Spangler
  /s/ James Lang
  Director
  March 12, 2019
  James Lang
  /s/ Gus D. Halas
  Director
  March 12, 2019
  Gus D. Halas
  7