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  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center"><B>As filed with the Securities and Exchange
  Commission on December 11, 2015.</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: right"><B>Registration No. 333-_____</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: right"></P>
  
  <!-- Field: Rule-Page --><DIV ALIGN="LEFT" STYLE="margin-top: 0; margin-bottom: 0"><DIV STYLE="font-size: 1pt; border-top: Black 2pt solid; border-bottom: Black 1pt solid; width: 100%; text-align: center">&nbsp;</DIV></DIV><!-- Field: /Rule-Page -->
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 0; text-align: center">&nbsp;</P>
  
  
  
  
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center"><B>SECURITIES AND EXCHANGE COMMISSION</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 0; text-align: center"><B>WASHINGTON, D.C. 20549</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 0; text-align: center"><B>&nbsp;</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 0; text-align: center"><B></B></P>
  
  <!-- Field: Rule-Page --><DIV ALIGN="CENTER" STYLE="margin-top: 0; margin-bottom: 0"><DIV STYLE="font-size: 1pt; border-top: Black 1.5pt solid; width: 25%">&nbsp;</DIV></DIV><!-- Field: /Rule-Page -->
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 0; text-align: center"><B>&nbsp;</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 0; text-align: center"><B>FORM S-8</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 0; text-align: center"><B>REGISTRATION STATEMENT</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center"><B>UNDER</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 0; text-align: center"><B>THE SECURITIES ACT
  OF 1933</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 0; text-align: center"><B>&nbsp;</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 0; text-align: center"><B></B></P>
  
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  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 0; text-align: center"><B>&nbsp;</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 0; text-align: center">SOLIGENIX, INC.</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 0; text-align: center"><I>(Exact Name of Registrant
  as Specified in its Charter)</I></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 0; text-align: center"><I>&nbsp;</I></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 0; text-align: center"><I></I></P>
  
  <!-- Field: Rule-Page --><DIV ALIGN="CENTER" STYLE="margin-top: 0; margin-bottom: 0"><DIV STYLE="font-size: 1pt; border-top: Black 1.5pt solid; width: 25%">&nbsp;</DIV></DIV><!-- Field: /Rule-Page -->
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 0; text-align: center"><I>&nbsp;</I></P>
  
  <TABLE CELLSPACING="0" CELLPADDING="0" STYLE="width: 100%">
  <tr>
      <TD STYLE="vertical-align: top; width: 49%; border-bottom: black 1.5pt solid; font: 10pt Times New Roman, Times, Serif; text-align: center"><font style="font-size: 10pt"><b>Delaware</b></font></td>
      <TD STYLE="vertical-align: bottom; width: 2%; padding-bottom: 1.5pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</td>
      <TD STYLE="vertical-align: top; width: 49%; border-bottom: black 1.5pt solid; font: 10pt Times New Roman, Times, Serif; text-align: center"><font style="font-size: 10pt"><b>41-1505029</b></font></td></tr>
  <tr>
      <TD STYLE="vertical-align: top">
          <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center"><i>(State or Other Jurisdiction of</i></P>
          <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center"><i>Incorporation or Organization)</i></P></td>
      <TD STYLE="vertical-align: bottom; font: 10pt Times New Roman, Times, Serif">&nbsp;</td>
      <TD STYLE="vertical-align: top">
          <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center"><i>(I.R.S. Employer</i></P>
          <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center"><i>Identification No.)</i></P></td></tr>
  </table>
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 0; text-align: center">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 0; text-align: center"><B>29 Emmons Drive, Suite C-10</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 0; text-align: center"><B>Princeton, New Jersey 08540</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 0; text-align: center"><I>(Address, Including
  Zip Code, of Principal Executive Offices)</I></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 0; text-align: center"><I>&nbsp;</I></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 0; text-align: center"><I></I></P>
  
  <!-- Field: Rule-Page --><DIV ALIGN="CENTER" STYLE="margin-top: 0; margin-bottom: 0"><DIV STYLE="font-size: 1pt; border-top: Black 1.5pt solid; width: 25%">&nbsp;</DIV></DIV><!-- Field: /Rule-Page -->
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 0; text-align: center"><I>&nbsp;</I></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 0; text-align: center"><B>Soligenix, Inc. 2015 Equity Incentive Plan</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center"><I>(Full Title of the Plan)</I></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center"><I>&nbsp;</I></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center"><I></I></P>
  
  <!-- Field: Rule-Page --><DIV ALIGN="CENTER" STYLE="margin-top: 0; margin-bottom: 0"><DIV STYLE="font-size: 1pt; border-top: Black 1.5pt solid; width: 25%">&nbsp;</DIV></DIV><!-- Field: /Rule-Page -->
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center"><I>&nbsp;</I></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 0; text-align: center"><B>Christopher J. Schaber, Ph.D.</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 0; text-align: center"><B>President and Chief Executive Officer</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 0; text-align: center"><B>Soligenix, Inc.</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 0; text-align: center"><B>29 Emmons Drive, Suite C-10</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 0; text-align: center"><B>Princeton, New Jersey 08540</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 0; text-align: center"><B>(609) 538-8200</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 0; text-align: center"><I>(Name, Address and Telephone Number, Including
  Area Code, of Agent for Service)</I></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0; text-align: center; margin-bottom: 0">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 0; text-align: center"><B>with copies to:</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0; text-align: center; margin-bottom: 0">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 0; text-align: center"><B>Leslie J. Croland, Esq.</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 0; text-align: center"><B>Duane Morris LLP</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 0; text-align: center"><B>Suite 3400</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 0; text-align: center"><B>200 South Biscayne Boulevard</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 0; text-align: center"><B>Miami, Florida 33131-2318</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 0; text-align: center"><B>(305) 960-2200</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 0; text-align: center"><B>&nbsp;</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 0; text-align: center"><B></B></P>
  
  <!-- Field: Rule-Page --><DIV ALIGN="CENTER" STYLE="margin-top: 0; margin-bottom: 0"><DIV STYLE="font-size: 1pt; border-top: Black 1.5pt solid; width: 25%">&nbsp;</DIV></DIV><!-- Field: /Rule-Page -->
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 0; text-align: center"><B>&nbsp;</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify">Indicate by check mark whether the registrant
  is a large accelerated filer, an accelerated filer, a non-accelerated filer, or a smaller reporting company. See the definitions
  of &ldquo;large accelerated filer,&rdquo; &ldquo;accelerated filer,&rdquo; and &ldquo;smaller reporting company&rdquo; in Rule
  12b-2 of the Exchange Act. (Check one):</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-indent: 0.5in">&nbsp;</P>
  
  <TABLE CELLSPACING="0" CELLPADDING="0" STYLE="width: 100%; font: 10pt Calibri, Helvetica, Sans-Serif; border-collapse: collapse">
  <TR STYLE="vertical-align: top">
      <TD STYLE="width: 0.5in">&nbsp;</TD>
      <TD STYLE="padding: 0; line-height: 115%; text-indent: 0; width: 37%"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">Large accelerated filer</FONT></TD>
      <TD STYLE="padding: 0; line-height: 115%; text-indent: 0; width: 10%"><FONT STYLE="font: 10pt Wingdings">&#168;</FONT></TD>
      <TD STYLE="padding: 0; line-height: 115%; text-indent: 0"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">Accelerated
  filer</FONT></TD>
      <TD STYLE="padding: 0; line-height: 115%; text-indent: 0; width: 10%"><FONT STYLE="font: 10pt Wingdings">&#168;</FONT></TD></TR>
  <TR STYLE="vertical-align: top">
      <TD>&nbsp;</TD>
      <TD STYLE="padding: 0; line-height: 115%; text-indent: 0">&nbsp;</TD>
      <TD STYLE="padding: 0; line-height: 115%; text-indent: 0">&nbsp;</TD>
      <TD STYLE="padding: 0; line-height: 115%; text-indent: 0">&nbsp;</TD>
      <TD STYLE="padding: 0; line-height: 115%; text-indent: 0">&nbsp;</TD></TR>
  <TR STYLE="vertical-align: top">
      <TD>&nbsp;</TD>
      <TD STYLE="padding: 0; line-height: 115%; text-indent: 0"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">Non-accelerated filer</FONT></TD>
      <TD STYLE="padding: 0; line-height: 115%; text-indent: 0"><FONT STYLE="font: 10pt Wingdings">&#168;</FONT></TD>
      <TD STYLE="padding: 0; line-height: 115%; text-indent: 0"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">Smaller reporting
  company</FONT></TD>
      <TD STYLE="padding: 0; line-height: 115%; text-indent: 0"><FONT STYLE="font: 10pt Wingdings">x</FONT></TD></TR>
  </TABLE>
  
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center"></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 0; text-align: center"><B>&nbsp;</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 0; text-align: center"><B></B></P>
  
  <!-- Field: Page; Sequence: 1 -->
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      <DIV STYLE="page-break-before: always; margin-top: 6pt; margin-bottom: 12pt"><P STYLE="margin: 0pt">&nbsp;</P></DIV>
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  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 0; text-align: center"><B>&nbsp;</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 0; text-align: center"><B>CALCULATION OF REGISTRATION FEE</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 0; text-align: center">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-indent: 0.5in"></P>
  
  <TABLE CELLPADDING="0" CELLSPACING="0" STYLE="border-collapse: collapse; width: 100%; font: 10pt Times New Roman, Times, Serif">
  <TR STYLE="vertical-align: bottom">
      <TD STYLE="text-align: center; border-bottom: Black 1.5pt solid"><P STYLE="font: 10pt/normal Times New Roman, Times, Serif; margin-top: 0; text-align: center; margin-bottom: 0"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">&nbsp;</FONT></P><P STYLE="font: 10pt/normal Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 0; text-align: center"><FONT STYLE="font: 10pt Times New Roman, Times, Serif"><B>Title of Each Class</B></FONT></P> <P STYLE="font: 10pt/normal Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 0; text-align: center"><FONT STYLE="font: 10pt Times New Roman, Times, Serif"><B>of Securities to be Registered</B></FONT></P></TD><TD STYLE="font-weight: bold; padding-bottom: 1.5pt">&nbsp;</TD>
      <TD COLSPAN="2" STYLE="font-weight: bold; text-align: center; border-bottom: Black 1.5pt solid">Amount to be &nbsp;registered</TD><TD NOWRAP STYLE="padding-bottom: 1.5pt; font-weight: bold">&nbsp;</TD><TD STYLE="font-weight: bold; padding-bottom: 1.5pt">&nbsp;</TD>
      <TD COLSPAN="2" STYLE="font-weight: bold; text-align: center; border-bottom: Black 1.5pt solid">Proposed &nbsp;maximum &nbsp;offering &nbsp;price per &nbsp;share</TD><TD NOWRAP STYLE="padding-bottom: 1.5pt; font-weight: bold">&nbsp;</TD><TD STYLE="font-weight: bold; padding-bottom: 1.5pt">&nbsp;</TD>
      <TD COLSPAN="2" STYLE="font-weight: bold; text-align: center; border-bottom: Black 1.5pt solid">Proposed &nbsp;maximum &nbsp;aggregate &nbsp;offering price</TD><TD NOWRAP STYLE="padding-bottom: 1.5pt; font-weight: bold">&nbsp;</TD><TD STYLE="font-weight: bold; padding-bottom: 1.5pt">&nbsp;</TD>
      <TD COLSPAN="2" STYLE="font-weight: bold; text-align: center; border-bottom: Black 1.5pt solid">Amount of &nbsp;registration fee</TD><TD NOWRAP STYLE="padding-bottom: 1.5pt; font-weight: bold">&nbsp;</TD></TR>
  <TR STYLE="vertical-align: bottom; background-color: rgb(204,238,255)">
      <TD STYLE="width: 52%; padding-bottom: 4pt">Common Stock, $0.001 par value per share</TD><TD STYLE="width: 1%; padding-bottom: 4pt">&nbsp;</TD>
      <TD STYLE="width: 1%; border-bottom: Black 4pt double; text-align: left">&nbsp;</TD><TD STYLE="width: 9%; border-bottom: Black 4pt double; text-align: right">3,000,000</TD><TD NOWRAP STYLE="width: 1%; padding-bottom: 4pt; text-align: left">(1)(2)</TD><TD STYLE="width: 1%; padding-bottom: 4pt">&nbsp;</TD>
      <TD STYLE="width: 1%; border-bottom: Black 4pt double; text-align: left">$</TD><TD STYLE="width: 9%; border-bottom: Black 4pt double; text-align: right">0.6975</TD><TD NOWRAP STYLE="width: 1%; padding-bottom: 4pt; text-align: left">(3)</TD><TD STYLE="width: 1%; padding-bottom: 4pt">&nbsp;</TD>
      <TD STYLE="width: 1%; border-bottom: Black 4pt double; text-align: left">$</TD><TD STYLE="width: 9%; border-bottom: Black 4pt double; text-align: right">2,092,500</TD><TD NOWRAP STYLE="width: 1%; padding-bottom: 4pt; text-align: left">(3)</TD><TD STYLE="width: 1%; padding-bottom: 4pt">&nbsp;</TD>
      <TD STYLE="width: 1%; border-bottom: Black 4pt double; text-align: left">$</TD><TD STYLE="width: 9%; border-bottom: Black 4pt double; text-align: right">210.72</TD><TD NOWRAP STYLE="width: 1%; padding-bottom: 4pt; text-align: left">(3)</TD></TR>
  </TABLE>
  
  
  
  
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-indent: 0.5in">&nbsp;</P>
  
  <table cellspacing="0" cellpadding="0" style="font: 10pt Times New Roman, Times, Serif; width: 100%">
  <tr style="vertical-align: top">
      <td style="width: 36px; text-align: justify"><font style="font-size: 10pt">(1)</font></td>
      <td style="text-align: justify"><font style="font-size: 10pt">This Registration Statement covers, in addition to the number of shares of common stock, par value $0.001 per share (the &ldquo;Common Stock&rdquo;), of Soligenix, Inc., a Delaware corporation (the &ldquo;Registrant&rdquo;), stated above, options and other rights to purchase or acquire the shares of Common Stock covered by this Registration Statement and, pursuant to Rule 416 under the Securities Act of 1933, as amended (the &ldquo;Securities Act&rdquo;), an additional indeterminate number of shares, options and rights that may be offered or issued pursuant to the Soligenix, Inc. 2015 Equity Incentive Plan, as amended (the &ldquo;Plan&rdquo;), as a result of one or more adjustments under the Plan to prevent dilution resulting from one or more stock splits, stock dividends or similar transactions.</font></td></tr>
  </table>
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify">&nbsp;</P>
  
  <table cellspacing="0" cellpadding="0" style="font: 10pt Times New Roman, Times, Serif; width: 100%">
  <tr style="vertical-align: top">
      <td style="width: 36px; text-align: justify"><font style="font-size: 10pt">(2)</font></td>
      <td style="text-align: justify"><font style="font-size: 10pt">This Registration Statement also covers the preferred stock purchase rights issuable in accordance with the Rights Agreement dated June 22, 2007, between the Registrant and American Stock Transfer &amp; Trust Company, LLC, as Rights Agent, which are presently attached to and trade with the Common Stock.</font></td></tr>
  </table>
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify">&nbsp;</P>
  
  <table cellspacing="0" cellpadding="0" style="font: 10pt Times New Roman, Times, Serif; width: 100%">
  <tr style="vertical-align: top">
      <td style="width: 36px; text-align: justify"><font style="font-size: 10pt">(3)</font></td>
      <td style="text-align: justify"><font style="font-size: 10pt">These figures are estimates made solely for the purpose of calculating the registration fee pursuant to Rule 457 under the Securities Act. The registration fee has been calculated in accordance with Rule 457(h)(1) based upon the average of the bid and asked prices of the Common Stock as reported on the OTCQB on December <b>7</b>, 2015.</font></td></tr>
  </table>
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0"></P>
  
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  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0"></P>
  
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  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 0; text-align: center"><B>PART I</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 0; text-align: center">INFORMATION REQUIRED IN THE SECTION 10(a) PROSPECTUS</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0; text-align: center; margin-bottom: 0">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 0; text-align: center">(not required to be filed as part of this Registration
  Statement)</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0; text-align: center; margin-bottom: 0">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 0; text-align: center"><B>PART II</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 0; text-align: center">INFORMATION REQUIRED IN THE REGISTRATION STATEMENT</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify">Item 3.&nbsp;&nbsp; &nbsp;<U>Incorporation
  of Documents by Reference</U>.</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify">The following documents, which previously have
  been filed by Soligenix, Inc. (the &ldquo;Registrant&rdquo;) with the Securities and Exchange Commission (the &ldquo;Commission&rdquo;),
  are incorporated herein by reference and made a part hereof:</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify">&nbsp;</P>
  
  <TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%">
  <tr style="vertical-align: top">
      <TD STYLE="width: 4%; text-align: justify">&nbsp;</td>
      <TD STYLE="width: 5%; text-align: justify"><font style="font-size: 10pt">(1)</font></td>
      <TD STYLE="text-align: justify"><font style="font-size: 10pt">The Registrant&rsquo;s Annual Report on Form 10-K for the fiscal year ended December 31, 2014;</font></td></tr>
  <tr style="vertical-align: top">
      <TD STYLE="text-align: justify">&nbsp;</td>
      <TD STYLE="text-align: justify"><font style="font-size: 10pt">(2)</font></td>
      <TD STYLE="text-align: justify"><font style="font-size: 10pt">The Registrant&rsquo;s Quarterly Report on Form 10-Q for the fiscal quarter March 31, 2015;</font></td></tr>
  <tr style="vertical-align: top">
      <TD STYLE="text-align: justify">&nbsp;</td>
      <TD STYLE="text-align: justify"><font style="font-size: 10pt">(3)</font></td>
      <TD STYLE="text-align: justify"><font style="font-size: 10pt">The Registrant&rsquo;s Quarterly Report on Form 10-Q for the fiscal quarter June 30, 2015;</font></td></tr>
  <tr style="vertical-align: top">
      <TD STYLE="text-align: justify">&nbsp;</td>
      <TD STYLE="text-align: justify"><font style="font-size: 10pt">(4)</font></td>
      <TD STYLE="text-align: justify"><font style="font-size: 10pt">The Registrant&rsquo;s Quarterly Report on Form 10-Q for the fiscal quarter September 30, 2015;</font></td></tr>
  <tr style="vertical-align: top">
      <TD STYLE="text-align: justify">&nbsp;</td>
      <TD STYLE="text-align: justify"><font style="font-size: 10pt">(5)</font></td>
      <TD STYLE="text-align: justify"><font style="font-size: 10pt">The Registrant's Current Report on Form 8-K filed with the Commission on January 7, 2015;</font></td></tr>
  <tr style="vertical-align: top">
      <TD STYLE="text-align: justify">&nbsp;</td>
      <TD STYLE="text-align: justify"><font style="font-size: 10pt">(6)</font></td>
      <TD STYLE="text-align: justify"><font style="font-size: 10pt">The Registrant's Current Report on Form 8-K filed with the Commission on June 3, 2015;</font></td></tr>
  <tr style="vertical-align: top">
      <TD STYLE="text-align: justify">&nbsp;</td>
      <TD STYLE="text-align: justify"><font style="font-size: 10pt">(7)</font></td>
      <TD STYLE="text-align: justify"><font style="font-size: 10pt">The Registrant's Current Report on Form 8-K filed with the Commission on June 19, 2015;</font></td></tr>
  <tr style="vertical-align: top">
      <TD STYLE="text-align: justify">&nbsp;</td>
      <TD STYLE="text-align: justify"><font style="font-size: 10pt">(8)</font></td>
      <TD STYLE="text-align: justify"><font style="font-size: 10pt">The Registrant's Current Report on Form 8-K filed with the Commission on July 31, 2015;</font></td></tr>
  <tr style="vertical-align: top">
      <TD STYLE="text-align: justify">&nbsp;</td>
      <TD STYLE="text-align: justify"><font style="font-size: 10pt">(9)</font></td>
      <TD STYLE="text-align: justify"><font style="font-size: 10pt">The Registrant's Current Report on Form 8-K filed with the Commission on August 19, 2015;</font></td></tr>
  <tr style="vertical-align: top">
      <TD STYLE="text-align: justify">&nbsp;</td>
      <TD STYLE="text-align: justify"><font style="font-size: 10pt">(10)</font></td>
      <TD STYLE="text-align: justify"><font style="font-size: 10pt">The description of the Common Stock, $0.001 par value, of the Registrant under the caption &quot;Description of Capital Stock&quot; contained in the Registrant's Amendment No. 1 to Registration Statement on Form S-1, as filed with the Securities and Exchange Commission on August 21, 2015 (Commission File No. 333-206055) and any amendment or report subsequently filed by the Registrant for the purpose of updating that description; and</font></td></tr>
  <tr style="vertical-align: top">
      <TD STYLE="text-align: justify">&nbsp;</td>
      <TD STYLE="text-align: justify"><font style="font-size: 10pt">(11)</font></td>
      <TD STYLE="text-align: justify"><font style="font-size: 10pt">The description of the Registrant&rsquo;s Preferred Stock Purchase Rights contained in its Registration Statement on Form 8-A filed with the Commission on June 22, 2007 (Commission File No. 000-&nbsp;16929) and any amendment or report subsequently filed by the Registrant for the purpose of updating that description.</font></td></tr>
  </table>
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify">In addition to the foregoing, all documents
  subsequently filed by the Registrant pursuant to Sections 13(a), 13(c), 14 and 15(d) of the Securities Exchange Act of 1934, as
  amended (the &ldquo;Exchange Act&rdquo;), prior to the filing of a post-effective amendment to this Registration Statement indicating
  that all of the securities offered hereunder have been sold or deregistering all securities then remaining unsold, shall be deemed
  to be incorporated by reference in this Registration Statement and to be part hereof from the date of filing of such documents
  (excluding information furnished in filings made under Items 2.02 or 7.01 of Form 8-K). Any statement contained in a document incorporated
  or deemed to be incorporated by reference in this Registration Statement shall be deemed to be modified or superseded for purposes
  of this Registration Statement to the extent that a statement contained herein or in any subsequently filed document that is or
  is deemed to be also incorporated by reference herein modified or supersedes such statement. Any statement so modified or superseded
  shall not be deemed, except as so modified or superseded, to constitute a part of this Registration Statement.</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify">Item 4.&nbsp;&nbsp; &nbsp;<U>Description of
  Securities</U>.</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify">Not applicable.</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify">Item 5.&nbsp;&nbsp;&nbsp; <U>Interests of Named
  Experts and Counsel</U>.</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify">Not applicable.</P>
  
  <P STYLE="font: 8pt Times New Roman, Times, Serif; margin: 0; text-align: justify; text-indent: 0.5in">&nbsp;</P>
  
  <P STYLE="font: 8pt Times New Roman, Times, Serif; margin: 0; text-align: justify; text-indent: 0.5in"></P>
  
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  <P STYLE="font: 8pt Times New Roman, Times, Serif; margin: 0; text-align: justify; text-indent: 0.5in">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify">Item 6.&nbsp;&nbsp;&nbsp; <U>Indemnification
  of Directors and Officers</U>.</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify">Section 102(b)(7) of the Delaware General Corporation
  Law allows companies to limit the personal liability of its directors to the company or its stockholders for monetary damages for
  breach of a fiduciary duty.&nbsp;&nbsp;Article IX of the Registrant&rsquo;s Certificate of Incorporation, as amended, provides
  for the limitation of personal liability of directors of the Registrant as follows:</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify">&quot;A Director of the Corporation shall have
  no personal liability to the Corporation or its stockholders for monetary damages for breach of his fiduciary duty as a Director;
  provided, however, this Article shall not eliminate or limit the liability of a Director (i) for any breach of the Director's duty
  of loyalty to the Corporation or its stockholders; (ii) for acts or omissions not in good faith or which involve intentional misconduct
  or a knowing violation of law; (iii) for the unlawful payment of dividends or unlawful stock repurchases under Section 174 of the
  General Corporation Law of the State of Delaware; or (iv) for any transaction from which the Director derived an improper personal
  benefit. If the General Corporation Law is amended after approval by the stockholders of this Article to authorize corporate action
  further eliminating or limiting the personal liability of directors, then the liability of a director of the Corporation shall
  be eliminated or limited to the fullest extent permitted by the General Corporation Law of the State of Delaware, as so amended.&quot;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify">Article VIII of the Registrant's Bylaws, as
  amended and restated, provide for indemnification of directors and officers to the fullest extent permitted by the Delaware General
  Corporation Law.</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify">Insofar as indemnification for liabilities
  arising under the Securities Act of 1933, as amended (the &ldquo;Securities Act&rdquo;), may be permitted to directors, officers
  or persons controlling the Registrant pursuant to the foregoing provisions, the Registrant has been informed that in the opinion
  of the Commission such indemnification is against public policy as expressed in the Securities Act and is therefore unenforceable.</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify">The Registrant has entered into indemnification
  agreements with its directors that would require the Registrant, subject to any limitations on the maximum permissible indemnification
  that may exist at law, to indemnify a director for claims that arise because of his service as a director.</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify">The Registrant has a directors&rsquo; and officers&rsquo;
  liability insurance policy.</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify">The above discussion is qualified in its entirety
  by reference to the Registrant&rsquo;s Certificate of Incorporation and Bylaws and the form of the indemnification agreement with
  directors.</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify">Item 7.&nbsp;&nbsp;&nbsp; <U>Exemption from
  Registration Claimed</U>.</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify">Not applicable.</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify">Item 8.&nbsp;&nbsp;&nbsp; <U>Exhibits</U>.</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify; text-indent: 0.5in">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify">A list of the exhibits included as part of
  this Registration Statement is set forth in the Exhibit Index which immediately precedes such exhibits and is hereby incorporated
  by reference herein.</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify">Item 9.&nbsp;&nbsp;&nbsp; <U>Undertakings</U>.</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify">(a)&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;The
  Registrant hereby undertakes:</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify; text-indent: 0.5in">(1)&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;To
  file, during any period in which offers or sales are being made, a post-effective amendment to this Registration Statement:</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify; text-indent: 27pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(i)&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;To
  include any prospectus required by Section 10(a)(3) of the Securities Act;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify; text-indent: 27pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(ii)&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;To
  reflect in the prospectus any facts or events arising after the effective date of this Registration Statement (or the most recent
  post-effective amendment thereof) which, individually or in the aggregate, represent a fundamental change in the information set
  forth in this Registration Statement. Notwithstanding the foregoing, any increase or decrease in volume of securities offered (if
  the total dollar value of securities offered would not exceed that which was registered) and any deviation from the low or high
  end of the estimated maximum offering range may be reflected in the form of prospectus filed with the Commission pursuant to Rule
  424(b) if, in the aggregate, the changes in volume and price represent no more than a 20% change in the maximum aggregate offering
  price set forth in the &quot;Calculation of Registration Fee&quot; table in the effective registration statement; and</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify"></P>
  
  <!-- Field: Page; Sequence: 4; Value: 3 -->
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      <!-- Field: /Page -->
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify; text-indent: 27pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(iii)&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;To
  include any material information with respect to the plan of distribution not previously disclosed in this Registration Statement
  or any material change to such information in this Registration Statement;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify">provided, however, that paragraphs (i) and
  (ii) shall not apply if the information required to be included in a post-effective amendment by those paragraphs is contained
  in periodic reports filed with or furnished to the Commission by the Registrant pursuant to section 13 or section 15(d) of the
  Securities Exchange Act that are incorporated by reference in this Registration Statement;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify; text-indent: 0.5in">(2)&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;That,
  for the purpose of determining any liability under the Securities Act, each such post-effective amendment shall be deemed to be
  a new registration statement relating to the securities offered therein, and the offering of such securities at that time shall
  be deemed to be the initial bona fide offering thereof.</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify; text-indent: 0.5in">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify; text-indent: 0.5in">(3)&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;To
  remove from registration by means of a post-effective amendment any of the securities being registered which remain unsold at the
  termination of the offering.</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify">(b)&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;The
  Registrant hereby further undertakes that, for purposes of determining any liability under the Securities Act, each filing of the
  Registrant&rsquo;s Annual Report pursuant to Section 13(a) or Section 15(d) of the Exchange Act that is incorporated by reference
  in the Registration Statement shall be deemed to be a new registration statement relating to the securities offered therein, and
  the offering of such securities at that time shall be deemed to be the initial bona fide offering thereof.</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify">(c)&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Insofar
  as indemnification for liabilities arising under the Securities Act may be permitted to directors, officers and controlling persons
  of the Registrant pursuant to the foregoing provisions, or otherwise, the Registrant has been advised that in the opinion of the
  Commission such indemnification is against public policy as expressed in the Securities Act and is, therefore, unenforceable. In
  the event that a claim for indemnification against such liabilities (other than the payment by the Registrant of expenses incurred
  or paid by a director, officer or controlling person of the Registrant in the successful defense of any action, suit or proceeding)
  is asserted by such director, officer or controlling person in connection with the securities being registered, the Registrant
  will, unless in the opinion of its counsel the matter has been settled by controlling precedent, submit to a court of appropriate
  jurisdiction the question whether such indemnification by it is against public policy as expressed in the Securities Act and will
  be governed by the final adjudication of such issue.</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0"></P>
  
  <!-- Field: Page; Sequence: 5; Value: 3 -->
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      <DIV STYLE="page-break-before: always; margin-top: 6pt; margin-bottom: 12pt"><P STYLE="margin: 0pt">&nbsp;</P></DIV>
      <!-- Field: /Page -->
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0; text-align: center; margin-bottom: 0"><B>&nbsp;</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 0; text-align: center"><B>SIGNATURES</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0; text-align: center; margin-bottom: 0">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify; text-indent: 0.5in">Pursuant to the requirements
  of the Securities Act of 1933, the Registrant certifies that it has reasonable grounds to believe that it meets all of the requirements
  for filing on Form S-8 and has duly caused this Registration Statement to be signed on its behalf by the undersigned, thereunto
  duly authorized, in the city of Princeton, State of New Jersey, on this 11th day of December, 2015.</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>
  
  <TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
  <tr style="vertical-align: top">
      <TD>&nbsp;</td>
      <td colspan="2"><font style="font-size: 10pt"><b>SOLIGENIX, INC.</b></font></td></tr>
  <tr style="vertical-align: top">
      <TD STYLE="width: 60%">&nbsp;</td>
      <TD STYLE="width: 4%">&nbsp;</td>
      <TD STYLE="width: 36%">&nbsp;</td></tr>
  <tr style="vertical-align: top">
      <TD STYLE="padding-bottom: 1.5pt">&nbsp;</td>
      <TD STYLE="padding-bottom: 1.5pt"><font style="font-size: 10pt">By:</font></td>
      <TD STYLE="border-bottom: black 1.5pt solid"><font style="font-size: 10pt"><i>/s/ Christopher J. Schaber</i></font></td></tr>
  <tr style="vertical-align: top">
      <TD>&nbsp;</td>
      <TD>&nbsp;</td>
      <TD><font style="font-size: 10pt">Christopher J. Schaber</font></td></tr>
  <tr style="vertical-align: top">
      <TD>&nbsp;</td>
      <TD>&nbsp;</td>
      <TD><font style="font-size: 10pt">Chief Executive Officer and President</font></td></tr>
  </table>
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-indent: 0.5in">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 0; text-align: center"><B>POWER OF ATTORNEY</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify; text-indent: 0.5in">KNOW ALL MEN BY THESE PRESENTS,
  that each person whose signature appears below constitutes and appoints Christopher J. Schaber and Joseph Warusz, and each of them,
  his or her true and lawful attorneys-in-fact and agents, with full power of substitution and resubstitution, for him or her and
  in his or her name, place and stead in any and all capacities, to sign any or all amendments to this Registration Statement on
  Form S-8 (including post-effective amendments), and to file the same, with all exhibits thereto, and other documents in connection
  therewith with the United States Securities and Exchange Commission, granting unto said attorneys-in-fact and agents full power
  and authority to do and perform each and every act and thing requisite and necessary to be done in and about the premises, as fully
  and to all intents and purposes as he or she might or could do in person, hereby ratifying and confirming that said attorneys-in-fact
  and agents, or their substitute or substitutes, may lawfully do or cause to be done by virtue hereof.</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify; text-indent: 0.5in">Pursuant to the requirements
  of the Securities Act of 1933, this Registration Statement has been signed by the following persons in the capacities and on the
  dates indicated.</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>
  
  <TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
  <tr>
      <TD COLSPAN="2" STYLE="vertical-align: top; border-bottom: black 1.5pt solid; padding: 0; text-align: center; text-indent: 0"><font style="font-size: 10pt"><b>Signature</b></font></td>
      <TD STYLE="vertical-align: bottom; padding: 0; text-indent: 0">&nbsp;</td>
      <TD STYLE="vertical-align: bottom; border-bottom: black 1.5pt solid; padding: 0; text-align: center; text-indent: 0"><font style="font-size: 10pt"><b>Title</b></font></td>
      <TD STYLE="vertical-align: bottom; padding: 0; text-indent: 0">&nbsp;</td>
      <TD STYLE="vertical-align: bottom; border-bottom: black 1.5pt solid; padding: 0; text-align: center"><font style="font-size: 10pt"><b>Date</b></font></td></tr>
  <tr style="vertical-align: top">
      <TD STYLE="width: 3%; padding: 0; text-indent: 0">
          <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-indent: 0.5in">&nbsp;</P>
          <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">By:</P></td>
      <TD STYLE="width: 37%; border-bottom: black 1.5pt solid; padding: 0; text-indent: 0">
          <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-indent: 0.5in">&nbsp;</P>
          <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0"><i>/s/ Christopher J. Schaber</i></P></td>
      <TD STYLE="width: 2%; padding: 0; text-indent: 0">&nbsp;</td>
      <TD STYLE="width: 38%; padding: 0; text-indent: 0">&nbsp;</td>
      <TD STYLE="width: 2%; padding: 0; text-indent: 0">&nbsp;</td>
      <TD STYLE="width: 18%; padding: 0; text-align: center">&nbsp;</td></tr>
  <tr style="vertical-align: top">
      <TD STYLE="padding: 0; text-indent: 0">&nbsp;</td>
      <TD STYLE="padding: 0; text-indent: 0"><font style="font-size: 10pt">Christopher J. Schaber, PhD</font></td>
      <TD STYLE="padding: 0; text-indent: 0">&nbsp;</td>
      <TD STYLE="padding: 0; text-indent: 0">
          <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">Chairman, President and Chief Executive Officer</P>
          <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">(Principal Executive Officer)</P></td>
      <TD STYLE="padding: 0; text-indent: 0">&nbsp;</td>
      <TD STYLE="padding: 0; text-align: center">
          <P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 0; text-align: center">December 11, 2015</P>
          <P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 0; text-align: center">&nbsp;</P></td></tr>
  <tr style="vertical-align: top">
      <TD STYLE="padding: 0; text-indent: 0"><font style="font-size: 10pt">By:</font></td>
      <TD STYLE="border-bottom: black 1.5pt solid; padding: 0; text-indent: 0"><font style="font-size: 10pt"><i>/s/ Keith L. Brownlie</i></font></td>
      <TD STYLE="padding: 0; text-indent: 0">&nbsp;</td>
      <TD STYLE="padding: 0; text-indent: 0">&nbsp;</td>
      <TD STYLE="padding: 0; text-indent: 0">&nbsp;</td>
      <TD STYLE="padding: 0; text-align: center">&nbsp;</td></tr>
  <tr style="vertical-align: top">
      <TD STYLE="padding: 0; text-indent: 0">&nbsp;</td>
      <TD STYLE="padding: 0; text-indent: 0"><font style="font-size: 10pt">Keith L. Brownlie, CPA</font></td>
      <TD STYLE="padding: 0; text-indent: 0">&nbsp;</td>
      <TD STYLE="padding: 0; text-indent: 0"><font style="font-size: 10pt">Director</font></td>
      <TD STYLE="padding: 0; text-indent: 0">&nbsp;</td>
      <TD STYLE="padding: 0; text-align: center">
          <P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 0; text-align: center">December 11, 2015</P>
          <P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 0; text-align: center">&nbsp;</P></td></tr>
  <tr style="vertical-align: top">
      <TD STYLE="padding: 0; text-indent: 0"><font style="font-size: 10pt">By:</font></td>
      <TD STYLE="border-bottom: black 1.5pt solid; padding: 0; text-indent: 0"><font style="font-size: 10pt"><i>/s/ Marco M. Brughera</i></font></td>
      <TD STYLE="padding: 0; text-indent: 0">&nbsp;</td>
      <TD STYLE="padding: 0; text-indent: 0">&nbsp;</td>
      <TD STYLE="padding: 0; text-indent: 0">&nbsp;</td>
      <TD STYLE="padding: 0; text-align: center">&nbsp;</td></tr>
  <tr style="vertical-align: top">
      <TD STYLE="padding: 0; text-indent: 0">&nbsp;</td>
      <TD STYLE="padding: 0; text-indent: 0"><font style="font-size: 10pt">Marco M. Brughera, D.V.M.</font></td>
      <TD STYLE="padding: 0; text-indent: 0">&nbsp;</td>
      <TD STYLE="padding: 0; text-indent: 0"><font style="font-size: 10pt">Director</font></td>
      <TD STYLE="padding: 0; text-indent: 0">&nbsp;</td>
      <TD STYLE="padding: 0; text-align: center">
          <P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 0; text-align: center">December 11, 2015</P>
          <P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 0; text-align: center">&nbsp;</P></td></tr>
  <tr style="vertical-align: top">
      <TD STYLE="padding: 0; text-indent: 0"><font style="font-size: 10pt">By:</font></td>
      <TD STYLE="border-bottom: black 1.5pt solid; padding: 0; text-indent: 0"><font style="font-size: 10pt"><i>/s/ Gregg A. Lapointe</i></font></td>
      <TD STYLE="padding: 0; text-indent: 0">&nbsp;</td>
      <TD STYLE="padding: 0; text-indent: 0">&nbsp;</td>
      <TD STYLE="padding: 0; text-indent: 0">&nbsp;</td>
      <TD STYLE="padding: 0; text-align: center">&nbsp;</td></tr>
  <tr style="vertical-align: top">
      <TD STYLE="padding: 0; text-indent: 0">&nbsp;</td>
      <TD STYLE="padding: 0; text-indent: 0"><font style="font-size: 10pt">Gregg A. Lapointe, CPA</font></td>
      <TD STYLE="padding: 0; text-indent: 0">&nbsp;</td>
      <TD STYLE="padding: 0; text-indent: 0"><font style="font-size: 10pt">Director</font></td>
      <TD STYLE="padding: 0; text-indent: 0">&nbsp;</td>
      <TD STYLE="padding: 0; text-align: center">
          <P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 0; text-align: center">December 11, 2015</P>
          <P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 0; text-align: center">&nbsp;</P></td></tr>
  <tr>
      <TD STYLE="vertical-align: bottom; padding: 0; text-indent: 0"><FONT STYLE="font-size: 10pt">By:</FONT></td>
      <TD STYLE="vertical-align: bottom; border-bottom: black 1.5pt solid; padding: 0; text-indent: 0"><font style="font-size: 10pt"><i>/s/ Robert J. Rubin</i></font></td>
      <TD STYLE="vertical-align: top; padding: 0; text-indent: 0">&nbsp;</td>
      <TD STYLE="vertical-align: top; padding: 0; text-indent: 0">&nbsp;</td>
      <TD STYLE="vertical-align: top; padding: 0; text-indent: 0">&nbsp;</td>
      <TD STYLE="vertical-align: top; padding: 0; text-align: center">&nbsp;</td></tr>
  <tr style="vertical-align: top">
      <TD STYLE="padding: 0; text-indent: 0">&nbsp;</td>
      <TD STYLE="padding: 0; text-indent: 0"><font style="font-size: 10pt">Robert J. Rubin, MD</font></td>
      <TD STYLE="padding: 0; text-indent: 0">&nbsp;</td>
      <TD STYLE="padding: 0; text-indent: 0"><font style="font-size: 10pt">Director</font></td>
      <TD STYLE="padding: 0; text-indent: 0">&nbsp;</td>
      <TD STYLE="padding: 0; text-align: center">
          <P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 0; text-align: center">December 11, 2015</P>
          <P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 0; text-align: center">&nbsp;</P></td></tr>
  <tr>
      <TD STYLE="vertical-align: bottom; padding: 0; text-indent: 0"><FONT STYLE="font-size: 10pt">By:</FONT></td>
      <TD STYLE="vertical-align: bottom; border-bottom: black 1.5pt solid; padding: 0; text-indent: 0"><font style="font-size: 10pt"><i>/s/ Jerome Zeldis</i></font></td>
      <TD STYLE="vertical-align: top; padding: 0; text-indent: 0">&nbsp;</td>
      <TD STYLE="vertical-align: top; padding: 0; text-indent: 0">&nbsp;</td>
      <TD STYLE="vertical-align: top; padding: 0; text-indent: 0">&nbsp;</td>
      <TD STYLE="vertical-align: top; padding: 0; text-align: center">&nbsp;</td></tr>
  <tr style="vertical-align: top">
      <TD STYLE="padding: 0; text-indent: 0">&nbsp;</td>
      <TD STYLE="padding: 0; text-indent: 0"><font style="font-size: 10pt">Jerome Zeldis, MD, PhD</font></td>
      <TD STYLE="padding: 0; text-indent: 0">&nbsp;</td>
      <TD STYLE="padding: 0; text-indent: 0"><font style="font-size: 10pt">Director</font></td>
      <TD STYLE="padding: 0; text-indent: 0">&nbsp;</td>
      <TD STYLE="padding: 0; text-align: center">
          <P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 0; text-align: center">December 11, 2015</P>
          <P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 0; text-align: center">&nbsp;</P></td></tr>
  <tr>
      <TD STYLE="vertical-align: bottom; padding: 0; text-indent: 0"><FONT STYLE="font-size: 10pt">By:</FONT></td>
      <TD STYLE="vertical-align: bottom; border-bottom: black 1.5pt solid; padding: 0; text-indent: 0"><font style="font-size: 10pt"><i>/s/ Joseph M. Warusz</i></font></td>
      <TD STYLE="vertical-align: top; padding: 0; text-indent: 0">&nbsp;</td>
      <TD STYLE="vertical-align: top; padding: 0; text-indent: 0">&nbsp;</td>
      <TD STYLE="vertical-align: top; padding: 0; text-indent: 0">&nbsp;</td>
      <TD STYLE="vertical-align: top; padding: 0; text-align: center">&nbsp;</td></tr>
  <tr style="vertical-align: top">
      <TD STYLE="padding: 0; text-indent: 0">&nbsp;</td>
      <TD STYLE="padding: 0; text-indent: 0"><font style="font-size: 10pt">Joseph M. Warusz, CPA</font></td>
      <TD STYLE="padding: 0; text-indent: 0">&nbsp;</td>
      <TD STYLE="padding: 0; text-indent: 0"><font style="font-size: 10pt">Vice President of Finance, Acting Chief Financial Officer and Corporate Secretary (Principal Financial and Accounting Officer)</font></td>
      <TD STYLE="padding: 0; text-indent: 0"></td>
      <TD STYLE="padding: 0; text-align: center">
          <P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 0; text-align: center"> December 11,
          2015</P>
          <P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 0; text-align: center">&nbsp;</P></td></tr>
  </table>
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center"></P>
  
  <!-- Field: Page; Sequence: 6; Value: 3 -->
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  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 0; text-align: center">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 0; text-align: center"><B>EXHIBIT INDEX</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0; text-align: center; margin-bottom: 0">&nbsp;</P>
  
  <TABLE CELLPADDING="0" CELLSPACING="0" STYLE="border-collapse: collapse; width: 100%; font: 10pt Times New Roman, Times, Serif">
  <TR STYLE="vertical-align: bottom">
      <TD STYLE="border-bottom: Black 1.5pt solid; text-align: left; vertical-align: top">Exhibit<BR>
  Number</TD><TD STYLE="padding-bottom: 1.5pt">&nbsp;</TD>
      <TD STYLE="border-bottom: Black 1.5pt solid">Description</TD></TR>
  <TR STYLE="vertical-align: bottom">
      <TD STYLE="text-align: left; vertical-align: top">&nbsp;</TD><TD>&nbsp;</TD>
      <TD>&nbsp;</TD></TR>
  <TR STYLE="vertical-align: bottom; background-color: rgb(204,238,255)">
      <TD STYLE="width: 9%; text-align: left; vertical-align: top">4.1</TD><TD STYLE="width: 1%">&nbsp;</TD>
      <TD STYLE="width: 90%; text-align: justify">Second Amended and Restated Certificate of Incorporation (incorporated by reference to Exhibit 3.1 included in the Registrant&rsquo;s current report on Form 8-K filed on June 22, 2012).</TD></TR>
  <TR STYLE="vertical-align: bottom; background-color: White">
      <TD STYLE="text-align: left; vertical-align: top">&nbsp;</TD><TD>&nbsp;</TD>
      <TD>&nbsp;</TD></TR>
  <TR STYLE="vertical-align: bottom; background-color: rgb(204,238,255)">
      <TD STYLE="text-align: left; vertical-align: top">4.2</TD><TD>&nbsp;</TD>
      <TD STYLE="text-align: justify">Bylaws (incorporated by reference to Exhibit 3.1 included in the Registrant&rsquo;s Quarterly Report on Form 10-QSB, as amended, for the fiscal quarter ended June 30, 2003).</TD></TR>
  <TR STYLE="vertical-align: bottom; background-color: White">
      <TD STYLE="text-align: left; vertical-align: top">&nbsp;</TD><TD>&nbsp;</TD>
      <TD>&nbsp;</TD></TR>
  <TR STYLE="vertical-align: bottom; background-color: rgb(204,238,255)">
      <TD STYLE="text-align: left; vertical-align: top">4.3</TD><TD>&nbsp;</TD>
      <TD STYLE="text-align: justify">Rights Agreement dated June 22, 2007, between the Registrant and American Stock Transfer &amp; Trust Company, LLC, as Rights Agent (incorporated by reference to Exhibit 4.1 included in the Registrant&rsquo;s current report on Form 8-K filed on June 22, 2007).</TD></TR>
  <TR STYLE="vertical-align: bottom; background-color: White">
      <TD STYLE="text-align: left; vertical-align: top">&nbsp;</TD><TD>&nbsp;</TD>
      <TD>&nbsp;</TD></TR>
  <TR STYLE="vertical-align: bottom; background-color: rgb(204,238,255)">
      <TD STYLE="text-align: left; vertical-align: top">5.1</TD><TD>&nbsp;</TD>
      <TD STYLE="text-align: left">Opinion of Duane Morris LLP regarding legality of securities being registered. *</TD></TR>
  <TR STYLE="vertical-align: bottom; background-color: White">
      <TD STYLE="text-align: left; vertical-align: top">&nbsp;</TD><TD>&nbsp;</TD>
      <TD>&nbsp;</TD></TR>
  <TR STYLE="vertical-align: bottom; background-color: rgb(204,238,255)">
      <TD STYLE="text-align: left; vertical-align: top">23.1</TD><TD>&nbsp;</TD>
      <TD STYLE="text-align: left">Consent of Consent of EisnerAmper LLP. *</TD></TR>
  <TR STYLE="vertical-align: bottom; background-color: White">
      <TD STYLE="text-align: left; vertical-align: top">&nbsp;</TD><TD>&nbsp;</TD>
      <TD>&nbsp;</TD></TR>
  <TR STYLE="vertical-align: bottom; background-color: rgb(204,238,255)">
      <TD STYLE="text-align: left; vertical-align: top">23.2</TD><TD>&nbsp;</TD>
      <TD STYLE="text-align: left">Consent of Duane Morris LLP (included in Exhibit 5.1 to this Registration Statement). *</TD></TR>
  <TR STYLE="vertical-align: bottom; background-color: White">
      <TD STYLE="text-align: left; vertical-align: top">&nbsp;</TD><TD>&nbsp;</TD>
      <TD>&nbsp;</TD></TR>
  <TR STYLE="vertical-align: bottom; background-color: rgb(204,238,255)">
      <TD STYLE="text-align: left; vertical-align: top">24.1</TD><TD>&nbsp;</TD>
      <TD STYLE="text-align: left">Power of Attorney (included on signature pages of this Registration Statement). *</TD></TR>
  <TR STYLE="vertical-align: bottom; background-color: White">
      <TD STYLE="text-align: left; vertical-align: top">&nbsp;</TD><TD>&nbsp;</TD>
      <TD>&nbsp;</TD></TR>
  <TR STYLE="vertical-align: bottom; background-color: rgb(204,238,255)">
      <TD STYLE="text-align: left; vertical-align: top">99.1</TD><TD>&nbsp;</TD>
      <TD STYLE="text-align: justify">Soligenix, Inc. 2015 Equity Incentive Plan, as amended on June 9, 2015 (incorporated by reference to Exhibit 10.1 included in the Registrant&rsquo;s current report on Form 8-K filed on June 19, 2015).</TD></TR>
  <TR STYLE="vertical-align: bottom; background-color: White">
      <TD STYLE="text-align: left; vertical-align: top">&nbsp;</TD><TD>&nbsp;</TD>
      <TD STYLE="text-align: justify">&nbsp;</TD></TR>
  <TR STYLE="vertical-align: bottom; background-color: rgb(204,238,255)">
      <TD STYLE="text-align: left; vertical-align: top">99.2</TD><TD>&nbsp;</TD>
      <TD STYLE="text-align: justify">Form of Stock Option Agreement under the Soligenix, Inc. 2015 Equity Incentive Plan. *</TD></TR>
  </TABLE>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-indent: 0.5in">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-indent: 0.5in"></P>
  
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  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-indent: 0">*&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Filed
  herewith.</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-indent: 0.5in">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-indent: 0.5in">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0; text-align: center; margin-bottom: 0">7</P>
  
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text: As filed with the Securities and Exchange
  Commission on December 11, 2015.
  Registration No. 333-_____
  SECURITIES AND EXCHANGE COMMISSION
  WASHINGTON, D.C. 20549
  FORM S-8
  REGISTRATION STATEMENT
  UNDER
  THE SECURITIES ACT
  OF 1933
  SOLIGENIX, INC.
  (Exact Name of Registrant
  as Specified in its Charter)
  Delaware
  41-1505029
  (State or Other Jurisdiction of
  Incorporation or Organization)
  (I.R.S. Employer
  Identification No.)
  29 Emmons Drive, Suite C-10
  Princeton, New Jersey 08540
  (Address, Including
  Zip Code, of Principal Executive Offices)
  Soligenix, Inc. 2015 Equity Incentive Plan
  (Full Title of the Plan)
  Christopher J. Schaber, Ph.D.
  President and Chief Executive Officer
  Soligenix, Inc.
  29 Emmons Drive, Suite C-10
  Princeton, New Jersey 08540
  (609) 538-8200
  (Name, Address and Telephone Number, Including
  Area Code, of Agent for Service)
  with copies to:
  Leslie J. Croland, Esq.
  Duane Morris LLP
  Suite 3400
  200 South Biscayne Boulevard
  Miami, Florida 33131-2318
  (305) 960-2200
  Indicate by check mark whether the registrant
  is a large accelerated filer, an accelerated filer, a non-accelerated filer, or a smaller reporting company. See the definitions
  of "large accelerated filer," "accelerated filer," and "smaller reporting company" in Rule
  12b-2 of the Exchange Act. (Check one):
  Large accelerated filer
  ¨
  Accelerated
  filer
  ¨
  Non-accelerated filer
  ¨
  Smaller reporting
  company
  x
  CALCULATION OF REGISTRATION FEE
  Title of Each Class
  of Securities to be Registered
  Amount to be  registered
  Proposed  maximum  offering  price per  share
  Proposed  maximum  aggregate  offering price
  Amount of  registration fee
  Common Stock, $0.001 par value per share
  3,000,000
  (1)(2)
  $
  0.6975
  (3)
  $
  2,092,500
  (3)
  $
  210.72
  (3)
  (1)
  This Registration Statement covers, in addition to the number of shares of common stock, par value $0.001 per share (the "Common Stock"), of Soligenix, Inc., a Delaware corporation (the "Registrant"), stated above, options and other rights to purchase or acquire the shares of Common Stock covered by this Registration Statement and, pursuant to Rule 416 under the Securities Act of 1933, as amended (the "Securities Act"), an additional indeterminate number of shares, options and rights that may be offered or issued pursuant to the Soligenix, Inc. 2015 Equity Incentive Plan, as amended (the "Plan"), as a result of one or more adjustments under the Plan to prevent dilution resulting from one or more stock splits, stock dividends or similar transactions.
  (2)
  This Registration Statement also covers the preferred stock purchase rights issuable in accordance with the Rights Agreement dated June 22, 2007, between the Registrant and American Stock Transfer & Trust Company, LLC, as Rights Agent, which are presently attached to and trade with the Common Stock.
  (3)
  These figures are estimates made solely for the purpose of calculating the registration fee pursuant to Rule 457 under the Securities Act. The registration fee has been calculated in accordance with Rule 457(h)(1) based upon the average of the bid and asked prices of the Common Stock as reported on the OTCQB on December
  7
  , 2015.
  PART I
  INFORMATION REQUIRED IN THE SECTION 10(a) PROSPECTUS
  (not required to be filed as part of this Registration
  Statement)
  PART II
  INFORMATION REQUIRED IN THE REGISTRATION STATEMENT
  Item 3.
  Incorporation
  of Documents by Reference
  .
  The following documents, which previously have
  been filed by Soligenix, Inc. (the "Registrant") with the Securities and Exchange Commission (the "Commission"),
  are incorporated herein by reference and made a part hereof:
  (1)
  The Registrant's Annual Report on Form 10-K for the fiscal year ended December 31, 2014;
  (2)
  The Registrant's Quarterly Report on Form 10-Q for the fiscal quarter March 31, 2015;
  (3)
  The Registrant's Quarterly Report on Form 10-Q for the fiscal quarter June 30, 2015;
  (4)
  The Registrant's Quarterly Report on Form 10-Q for the fiscal quarter September 30, 2015;
  (5)
  The Registrant's Current Report on Form 8-K filed with the Commission on January 7, 2015;
  (6)
  The Registrant's Current Report on Form 8-K filed with the Commission on June 3, 2015;
  (7)
  The Registrant's Current Report on Form 8-K filed with the Commission on June 19, 2015;
  (8)
  The Registrant's Current Report on Form 8-K filed with the Commission on July 31, 2015;
  (9)
  The Registrant's Current Report on Form 8-K filed with the Commission on August 19, 2015;
  (10)
  The description of the Common Stock, $0.001 par value, of the Registrant under the caption "Description of Capital Stock" contained in the Registrant's Amendment No. 1 to Registration Statement on Form S-1, as filed with the Securities and Exchange Commission on August 21, 2015 (Commission File No. 333-206055) and any amendment or report subsequently filed by the Registrant for the purpose of updating that description; and
  (11)
  The description of the Registrant's Preferred Stock Purchase Rights contained in its Registration Statement on Form 8-A filed with the Commission on June 22, 2007 (Commission File No. 000- 16929) and any amendment or report subsequently filed by the Registrant for the purpose of updating that description.
  In addition to the foregoing, all documents
  subsequently filed by the Registrant pursuant to Sections 13(a), 13(c), 14 and 15(d) of the Securities Exchange Act of 1934, as
  amended (the "Exchange Act"), prior to the filing of a post-effective amendment to this Registration Statement indicating
  that all of the securities offered hereunder have been sold or deregistering all securities then remaining unsold, shall be deemed
  to be incorporated by reference in this Registration Statement and to be part hereof from the date of filing of such documents
  (excluding information furnished in filings made under Items 2.02 or 7.01 of Form 8-K). Any statement contained in a document incorporated
  or deemed to be incorporated by reference in this Registration Statement shall be deemed to be modified or superseded for purposes
  of this Registration Statement to the extent that a statement contained herein or in any subsequently filed document that is or
  is deemed to be also incorporated by reference herein modified or supersedes such statement. Any statement so modified or superseded
  shall not be deemed, except as so modified or superseded, to constitute a part of this Registration Statement.
  Item 4.
  Description of
  Securities
  .
  Not applicable.
  Item 5.
  Interests of Named
  Experts and Counsel
  .
  Not applicable.
  3
  Item 6.
  Indemnification
  of Directors and Officers
  .
  Section 102(b)(7) of the Delaware General Corporation
  Law allows companies to limit the personal liability of its directors to the company or its stockholders for monetary damages for
  breach of a fiduciary duty.  Article IX of the Registrant's Certificate of Incorporation, as amended, provides
  for the limitation of personal liability of directors of the Registrant as follows:
  "A Director of the Corporation shall have
  no personal liability to the Corporation or its stockholders for monetary damages for breach of his fiduciary duty as a Director;
  provided, however, this Article shall not eliminate or limit the liability of a Director (i) for any breach of the Director's duty
  of loyalty to the Corporation or its stockholders; (ii) for acts or omissions not in good faith or which involve intentional misconduct
  or a knowing violation of law; (iii) for the unlawful payment of dividends or unlawful stock repurchases under Section 174 of the
  General Corporation Law of the State of Delaware; or (iv) for any transaction from which the Director derived an improper personal
  benefit. If the General Corporation Law is amended after approval by the stockholders of this Article to authorize corporate action
  further eliminating or limiting the personal liability of directors, then the liability of a director of the Corporation shall
  be eliminated or limited to the fullest extent permitted by the General Corporation Law of the State of Delaware, as so amended."
  Article VIII of the Registrant's Bylaws, as
  amended and restated, provide for indemnification of directors and officers to the fullest extent permitted by the Delaware General
  Corporation Law.
  Insofar as indemnification for liabilities
  arising under the Securities Act of 1933, as amended (the "Securities Act"), may be permitted to directors, officers
  or persons controlling the Registrant pursuant to the foregoing provisions, the Registrant has been informed that in the opinion
  of the Commission such indemnification is against public policy as expressed in the Securities Act and is therefore unenforceable.
  The Registrant has entered into indemnification
  agreements with its directors that would require the Registrant, subject to any limitations on the maximum permissible indemnification
  that may exist at law, to indemnify a director for claims that arise because of his service as a director.
  The Registrant has a directors' and officers'
  liability insurance policy.
  The above discussion is qualified in its entirety
  by reference to the Registrant's Certificate of Incorporation and Bylaws and the form of the indemnification agreement with
  directors.
  Item 7.
  Exemption from
  Registration Claimed
  .
  Not applicable.
  Item 8.
  Exhibits
  .
  A list of the exhibits included as part of
  this Registration Statement is set forth in the Exhibit Index which immediately precedes such exhibits and is hereby incorporated
  by reference herein.
  Item 9.
  Undertakings
  .
  (a)           The
  Registrant hereby undertakes:
  (1)     To
  file, during any period in which offers or sales are being made, a post-effective amendment to this Registration Statement:
  (i)           To
  include any prospectus required by Section 10(a)(3) of the Securities Act;
  (ii)          To
  reflect in the prospectus any facts or events arising after the effective date of this Registration Statement (or the most recent
  post-effective amendment thereof) which, individually or in the aggregate, represent a fundamental change in the information set
  forth in this Registration Statement. Notwithstanding the foregoing, any increase or decrease in volume of securities offered (if
  the total dollar value of securities offered would not exceed that which was registered) and any deviation from the low or high
  end of the estimated maximum offering range may be reflected in the form of prospectus filed with the Commission pursuant to Rule
  424(b) if, in the aggregate, the changes in volume and price represent no more than a 20% change in the maximum aggregate offering
  price set forth in the "Calculation of Registration Fee" table in the effective registration statement; and
  4
  (iii)         To
  include any material information with respect to the plan of distribution not previously disclosed in this Registration Statement
  or any material change to such information in this Registration Statement;
  provided, however, that paragraphs (i) and
  (ii) shall not apply if the information required to be included in a post-effective amendment by those paragraphs is contained
  in periodic reports filed with or furnished to the Commission by the Registrant pursuant to section 13 or section 15(d) of the
  Securities Exchange Act that are incorporated by reference in this Registration Statement;
  (2)      That,
  for the purpose of determining any liability under the Securities Act, each such post-effective amendment shall be deemed to be
  a new registration statement relating to the securities offered therein, and the offering of such securities at that time shall
  be deemed to be the initial bona fide offering thereof.
  (3)      To
  remove from registration by means of a post-effective amendment any of the securities being registered which remain unsold at the
  termination of the offering.
  (b)           The
  Registrant hereby further undertakes that, for purposes of determining any liability under the Securities Act, each filing of the
  Registrant's Annual Report pursuant to Section 13(a) or Section 15(d) of the Exchange Act that is incorporated by reference
  in the Registration Statement shall be deemed to be a new registration statement relating to the securities offered therein, and
  the offering of such securities at that time shall be deemed to be the initial bona fide offering thereof.
  (c)           Insofar
  as indemnification for liabilities arising under the Securities Act may be permitted to directors, officers and controlling persons
  of the Registrant pursuant to the foregoing provisions, or otherwise, the Registrant has been advised that in the opinion of the
  Commission such indemnification is against public policy as expressed in the Securities Act and is, therefore, unenforceable. In
  the event that a claim for indemnification against such liabilities (other than the payment by the Registrant of expenses incurred
  or paid by a director, officer or controlling person of the Registrant in the successful defense of any action, suit or proceeding)
  is asserted by such director, officer or controlling person in connection with the securities being registered, the Registrant
  will, unless in the opinion of its counsel the matter has been settled by controlling precedent, submit to a court of appropriate
  jurisdiction the question whether such indemnification by it is against public policy as expressed in the Securities Act and will
  be governed by the final adjudication of such issue.
  5
  SIGNATURES
  Pursuant to the requirements
  of the Securities Act of 1933, the Registrant certifies that it has reasonable grounds to believe that it meets all of the requirements
  for filing on Form S-8 and has duly caused this Registration Statement to be signed on its behalf by the undersigned, thereunto
  duly authorized, in the city of Princeton, State of New Jersey, on this 11th day of December, 2015.
  SOLIGENIX, INC.
  By:
  /s/ Christopher J. Schaber
  Christopher J. Schaber
  Chief Executive Officer and President
  POWER OF ATTORNEY
  KNOW ALL MEN BY THESE PRESENTS,
  that each person whose signature appears below constitutes and appoints Christopher J. Schaber and Joseph Warusz, and each of them,
  his or her true and lawful attorneys-in-fact and agents, with full power of substitution and resubstitution, for him or her and
  in his or her name, place and stead in any and all capacities, to sign any or all amendments to this Registration Statement on
  Form S-8 (including post-effective amendments), and to file the same, with all exhibits thereto, and other documents in connection
  therewith with the United States Securities and Exchange Commission, granting unto said attorneys-in-fact and agents full power
  and authority to do and perform each and every act and thing requisite and necessary to be done in and about the premises, as fully
  and to all intents and purposes as he or she might or could do in person, hereby ratifying and confirming that said attorneys-in-fact
  and agents, or their substitute or substitutes, may lawfully do or cause to be done by virtue hereof.
  Pursuant to the requirements
  of the Securities Act of 1933, this Registration Statement has been signed by the following persons in the capacities and on the
  dates indicated.
  Signature
  Title
  Date
  By:
  /s/ Christopher J. Schaber
  Christopher J. Schaber, PhD
  Chairman, President and Chief Executive Officer
  (Principal Executive Officer)
  December 11, 2015
  By:
  /s/ Keith L. Brownlie
  Keith L. Brownlie, CPA
  Director
  December 11, 2015
  By:
  /s/ Marco M. Brughera
  Marco M. Brughera, D.V.M.
  Director
  December 11, 2015
  By:
  /s/ Gregg A. Lapointe
  Gregg A. Lapointe, CPA
  Director
  December 11, 2015
  By:
  /s/ Robert J. Rubin
  Robert J. Rubin, MD
  Director
  December 11, 2015
  By:
  /s/ Jerome Zeldis
  Jerome Zeldis, MD, PhD
  Director
  December 11, 2015
  By:
  /s/ Joseph M. Warusz
  Joseph M. Warusz, CPA
  Vice President of Finance, Acting Chief Financial Officer and Corporate Secretary (Principal Financial and Accounting Officer)
  December 11,
          2015
  6
  EXHIBIT INDEX
  Exhibit
  Number
  Description
  4.1
  Second Amended and Restated Certificate of Incorporation (incorporated by reference to Exhibit 3.1 included in the Registrant's current report on Form 8-K filed on June 22, 2012).
  4.2
  Bylaws (incorporated by reference to Exhibit 3.1 included in the Registrant's Quarterly Report on Form 10-QSB, as amended, for the fiscal quarter ended June 30, 2003).
  4.3
  Rights Agreement dated June 22, 2007, between the Registrant and American Stock Transfer & Trust Company, LLC, as Rights Agent (incorporated by reference to Exhibit 4.1 included in the Registrant's current report on Form 8-K filed on June 22, 2007).
  5.1
  Opinion of Duane Morris LLP regarding legality of securities being registered. *
  23.1
  Consent of Consent of EisnerAmper LLP. *
  23.2
  Consent of Duane Morris LLP (included in Exhibit 5.1 to this Registration Statement). *
  24.1
  Power of Attorney (included on signature pages of this Registration Statement). *
  99.1
  Soligenix, Inc. 2015 Equity Incentive Plan, as amended on June 9, 2015 (incorporated by reference to Exhibit 10.1 included in the Registrant's current report on Form 8-K filed on June 19, 2015).
  99.2
  Form of Stock Option Agreement under the Soligenix, Inc. 2015 Equity Incentive Plan. *
  *           Filed
  herewith.
  7