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  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>As filed with the Securities and Exchange Commission
  on March 9, 2022</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: right"><B>Registration No. 333- &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"></P>
  
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  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>UNITED STATES</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>SECURITIES AND EXCHANGE COMMISSION</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>Washington, D.C. 20549</B></P>
  
  
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"></P>
  
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  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>&nbsp;</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>FORM S-8</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>REGISTRATION STATEMENT UNDER THE SECURITIES
  ACT OF 1933</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>
  
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  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>Protara Therapeutics, Inc.</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">(Exact name of registrant as specified in its charter)</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"></P>
  
  <!-- Field: Rule-Page --><DIV STYLE="margin: 0 auto; width: 25%"><DIV STYLE="font-size: 1pt; border-top: Black 1.5pt solid">&nbsp;</DIV></DIV><!-- Field: /Rule-Page -->
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>
  
  
  
  <TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
    <TR>
      <TD STYLE="border-bottom: Black 1.5pt solid; vertical-align: top; width: 49%; padding-top: 0.25pt; padding-right: 0.25pt; padding-left: 0.25pt; font-size: 10pt; text-align: center"><FONT STYLE="font-size: 10pt"><B>Delaware</B></FONT></TD>
      <TD STYLE="padding: 0.25pt 0.25pt 1.5pt; vertical-align: bottom; width: 2%">&nbsp;</TD>
      <TD STYLE="border-bottom: Black 1.5pt solid; vertical-align: top; width: 49%; padding-top: 0.25pt; padding-right: 0.25pt; padding-left: 0.25pt; font-size: 10pt; text-align: center"><FONT STYLE="font-size: 10pt"><B>20-4580525</B></FONT></TD></TR>
    <TR>
      <TD STYLE="vertical-align: top; padding: 0.25pt; font-size: 10pt; text-align: center"><FONT STYLE="font-size: 10pt">(State or other jurisdiction of<BR>
  incorporation or organization)</FONT></TD>
      <TD STYLE="vertical-align: bottom; padding: 0.25pt">&nbsp;</TD>
      <TD STYLE="vertical-align: top; padding: 0.25pt; font-size: 10pt; text-align: center"><FONT STYLE="font-size: 10pt">(I.R.S. Employer<BR>
  Identification No.)</FONT></TD></TR>
    </TABLE>
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>345 Park Avenue South, Third Floor</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>New York, NY 10010</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">(Address of Principal Executive Offices) (Zip Code)</P>
  
  
  
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>&nbsp;</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"></P>
  
  <!-- Field: Rule-Page --><DIV STYLE="margin: 0 auto; width: 25%"><DIV STYLE="font-size: 1pt; border-top: Black 1.5pt solid">&nbsp;</DIV></DIV><!-- Field: /Rule-Page -->
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>&nbsp;</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>Amended and Restated 2014 Equity Incentive Plan,
  as amended</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>2014 Employee Stock Purchase Plan</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">(Full title of the plans)</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>Jesse Shefferman</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>President and Chief Executive Officer</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>Protara Therapeutics, Inc.</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>345 Park Avenue South, Third Floor</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>New York, NY 10010</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">(Name and address of agent for service)</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>(646) 844-0337</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">(Telephone number, including area code, of agent
  for service)</P>
  
  
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"></P>
  
  <!-- Field: Rule-Page --><DIV STYLE="margin: 0 auto; width: 25%"><DIV STYLE="font-size: 1pt; border-top: Black 1.5pt solid">&nbsp;</DIV></DIV><!-- Field: /Rule-Page -->
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B><I>Copies to:</I></B></P>
  
  <TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
    <TR>
      <TD STYLE="vertical-align: top; width: 49%; padding: 0.5pt; text-align: center"><FONT STYLE="font-size: 10pt"><B>Mary J. Grendell, Esq.<BR>
  General Counsel and Corporate Secretary</B></FONT></TD>
      <TD STYLE="vertical-align: bottom; width: 2%; padding: 0.5pt">&nbsp;</TD>
      <TD STYLE="vertical-align: top; width: 49%; padding: 0.5pt; text-align: center"><FONT STYLE="font-size: 10pt"><B>Ryan S. Sansom, Esq.</B></FONT></TD></TR>
    <TR>
      <TD STYLE="vertical-align: top; padding: 0.5pt; text-align: center"><FONT STYLE="font-size: 10pt">Protara Therapeutics, Inc.</FONT></TD>
      <TD STYLE="vertical-align: bottom; padding: 0.5pt">&nbsp;</TD>
      <TD STYLE="vertical-align: top; padding: 0.5pt; text-align: center"><FONT STYLE="font-size: 10pt"><B>Karen E. Deschaine, Esq.</B></FONT></TD></TR>
    <TR>
      <TD STYLE="vertical-align: top; padding: 0.5pt; text-align: center"><FONT STYLE="font-size: 10pt">345 Park Avenue South, Third Floor</FONT></TD>
      <TD STYLE="vertical-align: bottom; padding: 0.5pt">&nbsp;</TD>
      <TD STYLE="vertical-align: top; padding: 0.5pt; text-align: center"><FONT STYLE="font-size: 10pt">Cooley LLP</FONT></TD></TR>
    <TR>
      <TD STYLE="vertical-align: top; padding: 0.5pt; text-align: center"><FONT STYLE="font-size: 10pt">New York, NY 10010</FONT></TD>
      <TD STYLE="vertical-align: bottom; padding: 0.5pt">&nbsp;</TD>
      <TD STYLE="vertical-align: top; padding: 0.5pt; text-align: center"><FONT STYLE="font-size: 10pt">4401 Eastgate Mall</FONT></TD></TR>
    <TR>
      <TD STYLE="vertical-align: top; padding: 0.5pt; text-align: center"><FONT STYLE="font-size: 10pt">(646) 844-0337</FONT></TD>
      <TD STYLE="vertical-align: bottom; padding: 0.5pt">&nbsp;</TD>
      <TD STYLE="vertical-align: top; padding: 0.5pt; text-align: center"><FONT STYLE="font-size: 10pt">San Diego, California 92121</FONT></TD></TR>
    <TR>
      <TD STYLE="vertical-align: top; padding: 0.5pt">&nbsp;</TD>
      <TD STYLE="vertical-align: bottom; padding: 0.5pt">&nbsp;</TD>
      <TD STYLE="vertical-align: top; padding: 0.5pt; text-align: center"><FONT STYLE="font-size: 10pt">(858) 550-6000</FONT></TD></TR>
    </TABLE>
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Indicate by check mark whether the registrant is a large accelerated
  filer, an accelerated filer, a non-accelerated filer, a smaller reporting company or an emerging growth company. See the definitions of
  &ldquo;large accelerated filer,&rdquo; &ldquo;accelerated filer,&rdquo; &ldquo;smaller reporting company&rdquo; and &ldquo;emerging growth
  company&rdquo; in Rule 12b-2 of the Exchange Act.</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
  
  <TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
    <TR STYLE="vertical-align: top">
      <TD STYLE="width: 18%; padding: 0.5pt"><FONT STYLE="font-size: 10pt">Large accelerated filer</FONT></TD>
      <TD STYLE="width: 46%; padding: 0.5pt"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#9744;</FONT></TD>
      <TD STYLE="width: 22%; padding: 0.5pt"><FONT STYLE="font-size: 10pt">Accelerated filer</FONT></TD>
      <TD STYLE="width: 14%; padding: 0.5pt"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#9744;</FONT></TD></TR>
    <TR STYLE="vertical-align: top">
      <TD STYLE="padding: 0.5pt"><FONT STYLE="font-size: 10pt">Non-accelerated filer</FONT></TD>
      <TD STYLE="padding: 0.5pt"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#9746;</FONT></TD>
      <TD STYLE="padding: 0.5pt"><FONT STYLE="font-size: 10pt">Smaller reporting company</FONT></TD>
      <TD STYLE="padding: 0.5pt"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#9746;</FONT></TD></TR>
    <TR STYLE="vertical-align: top">
      <TD STYLE="padding: 0.5pt">&nbsp;</TD>
      <TD STYLE="padding: 0.5pt">&nbsp;</TD>
      <TD STYLE="padding: 0.5pt"><FONT STYLE="font-size: 10pt">Emerging growth company</FONT></TD>
      <TD STYLE="padding: 0.5pt"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#9744;</FONT></TD></TR>
    </TABLE>
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
  
  <P STYLE="text-align: left; font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">If an emerging growth company, indicate by check mark if the registrant
  has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant
  to Section 7(a)(2)(B) of the Securities Act.&nbsp;<FONT STYLE="font-family: Times New Roman, Times, Serif">&#9744;</FONT><B>&nbsp;</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
  
  
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B></B></P>
  
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  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>&nbsp;</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"></P>
  
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  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>&nbsp;</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>PART I</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>&nbsp;</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>EXPLANATORY NOTE</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Protara Therapeutics, Inc. (the &ldquo;Registrant&rdquo;) is filing
  this Registration Statement on Form S-8 (the &ldquo;Registration Statement&rdquo;) for the purpose of registering an additional 840,181
  shares of common stock under the Registrant&rsquo;s Amended and Restated 2014 Equity Incentive Plan, as amended (the &ldquo;EIP&rdquo;),
  and an additional 7,025 shares of common stock under the Registrant&rsquo;s 2014 Employee Stock Purchase Plan (the &ldquo;ESPP&rdquo;),
  pursuant to the &ldquo;evergreen&rdquo; provisions of each plan which provide for annual automatic increases in the number of shares of
  the Registrant&rsquo;s common stock (the &ldquo;Common Stock&rdquo;) reserved for issuance under each respective plan.</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"></P>
  
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  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>PART II</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>INFORMATION REQUIRED IN THE REGISTRATION STATEMENT</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B>ITEM 3. Incorporation of Documents by Reference. </B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">This Registration Statement is being filed for
  the purpose of increasing the number of securities of the same class as other securities for which Registration Statements of the Registrant
  on Form S-8 relating to the same employee benefit plan are effective. The Registrant previously registered shares of its Common Stock
  for issuance under the EIP and ESPP under Registration Statements on Form S-8 filed with the Securities and Exchange Commission (the &ldquo;SEC&rdquo;)
  on <A HREF="http://www.sec.gov/Archives/edgar/data/1359931/000117184314005694/fs8_112514.htm">November 25, 2014</A> (File No. 333-200587), <A HREF="http://www.sec.gov/Archives/edgar/data/1359931/000117184318000173/fs8_010418.htm">January 4, 2018</A> (File No. 333-222415), <A HREF="http://www.sec.gov/Archives/edgar/data/1359931/000117184319000095/fs8_010319.htm">January 3, 2019</A> (File No. 333-229123), <A HREF="http://www.sec.gov/Archives/edgar/data/1359931/000110465920004017/a20-3439_1s8.htm">January 15, 2020</A> (File No. 333-235918) and <A HREF="http://www.sec.gov/Archives/edgar/data/1359931/000121390021014711/ea137341-s8_protaratherap.htm">March 11, 2021</A> (File No. 333-254124). Pursuant to General Instruction E to Form S-8, this Registration
  Statement hereby incorporates by reference the contents of the Registration Statements referenced above.</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">The registrant hereby incorporates by reference
  into this Registration Statement the following documents previously filed by the registrant with the SEC (other than portions of Current
  Reports furnished under Item 2.02 or Item 7.01 of Form 8-K and exhibits related to such items or other portions of documents filed with
  the SEC which were furnished, but not filed, pursuant to applicable rules promulgated by the SEC):</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 1in; text-indent: -0.25in">&nbsp;</P>
  
  <TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
  <TD STYLE="width: 0.5in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Times New Roman, Times, Serif">&#9679;</FONT></TD><TD>the Company&rsquo;s Annual Report on Form 10-K filed with the SEC on <A HREF="http://www.sec.gov/ix?doc=/Archives/edgar/data/1359931/000121390022011208/f10k2021_protarathera.htm">March 9, 2022</A>;</TD></TR></TABLE>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in">&nbsp;</P>
  
  <TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
  <TD STYLE="width: 0.5in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Times New Roman, Times, Serif">&#9679;</FONT></TD><TD>the Company&rsquo;s Current Report on Form 8-K filed with the SEC on <A HREF="https://www.sec.gov/ix?doc=/Archives/edgar/data/1359931/000121390022001222/ea153715-8k_protarathera.htm">January
  10, 2022</A>; and</TD></TR></TABLE>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in">&nbsp;</P>
  
  <TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
  <TD STYLE="width: 0.5in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Times New Roman, Times, Serif">&#9679;</FONT></TD><TD>the description of the Company&rsquo;s Common Stock contained in the
  Company&rsquo;s Registration Statement on <A HREF="http://www.sec.gov/Archives/edgar/data/1359931/000110465914072025/a14-15225_88a12b.htm">Form
  8-A (File No. 001-36694) filed with the SEC on October 16, 2014</A> under the Securities Exchange Act of 1934, as amended (the &ldquo;Exchange Act&rdquo;),
  including any amendments or reports filed for the purpose of updating such description.</TD></TR></TABLE>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 1in; text-indent: -0.25in">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">In addition, all reports and other documents subsequently
  filed by the registrant pursuant to Sections 13(a), 13(c), 14 and 15(d) of the Exchange Act, other than Current Reports furnished under
  Item 2.02 or Item 7.01 of Form 8-K and exhibits furnished on such form that relate to such items, prior to the filing of a post-effective
  amendment which indicates that all securities offered have been sold or which deregisters all securities then remaining unsold, shall
  be deemed to be incorporated by reference herein and to be a part of this Registration Statement from the date of the filing of such reports
  and documents. Any statement contained in a document incorporated or deemed to be incorporated by reference herein shall be deemed to
  be modified or superseded for purposes of this Registration Statement to the extent that a statement herein or in any subsequently filed
  document which also is or is deemed to be incorporated by reference herein modifies or supersedes such statement. Any such statement so
  modified or superseded shall not constitute a part of this Registration Statement, except as so modified or superseded.</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in"></P>
  
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  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B>ITEM 8. EXHIBITS.</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
  
  <TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
    <TR STYLE="vertical-align: bottom">
      <TD STYLE="width: 10%; border-bottom: black 1.5pt solid; padding: 0.5pt 0.5pt 0.75pt; text-align: center"><FONT STYLE="font-size: 10pt"><B>Exhibit<BR>
  Number</B></FONT></TD>
      <TD STYLE="width: 1%; padding: 0.5pt 0.5pt 1.75pt">&nbsp;</TD>
      <TD STYLE="width: 89%; border-bottom: black 1.5pt solid; padding: 0.5pt 0.5pt 0.75pt; text-align: center"><FONT STYLE="font-size: 10pt"><B>Description</B></FONT></TD></TR>
    <TR>
      <TD STYLE="vertical-align: top; padding: 0.5pt">&nbsp;</TD>
      <TD STYLE="vertical-align: bottom; padding: 0.5pt">&nbsp;</TD>
      <TD STYLE="vertical-align: top; padding: 0.5pt">&nbsp;</TD></TR>
    <TR STYLE="background-color: rgb(204,238,255)">
      <TD STYLE="vertical-align: top; padding: 0.5pt; text-align: center"><FONT STYLE="font-size: 10pt">4.1</FONT></TD>
      <TD STYLE="vertical-align: bottom; padding: 0.5pt">&nbsp;</TD>
      <TD STYLE="vertical-align: top; padding: 0.5pt"><A HREF="http://www.sec.gov/Archives/edgar/data/1359931/000110465914074038/a14-15225_12ex3d1.htm"><FONT STYLE="font-size: 10pt">Sixth Amended and Restated Certificate of Incorporation (incorporated by reference to Exhibit 3.1 to the Registrant&rsquo;s Current Report on Form 8-K, filed with the SEC on October 27, 2014).</FONT></A></TD></TR>
    <TR STYLE="background-color: White">
      <TD STYLE="vertical-align: top; padding: 0.5pt">&nbsp;</TD>
      <TD STYLE="vertical-align: bottom; padding: 0.5pt">&nbsp;</TD>
      <TD STYLE="vertical-align: top; padding: 0.5pt">&nbsp;</TD></TR>
    <TR STYLE="background-color: rgb(204,238,255)">
      <TD STYLE="vertical-align: top; padding: 0.5pt; text-align: center"><FONT STYLE="font-size: 10pt">4.2</FONT></TD>
      <TD STYLE="vertical-align: bottom; padding: 0.5pt">&nbsp;</TD>
      <TD STYLE="vertical-align: top; padding: 0.5pt"><A HREF="http://www.sec.gov/Archives/edgar/data/1359931/000110465920003115/tm201618d1_ex3-1.htm"><FONT STYLE="font-size: 10pt">Certificate of Amendment to the Sixth Amended and Restated Certificate of Incorporation (incorporated by reference to Exhibit 3.1 to the Registrant&rsquo;s Current Report on Form 8-K, filed with the SEC on January 10, 2020).</FONT></A></TD></TR>
    <TR STYLE="background-color: White">
      <TD STYLE="vertical-align: top; padding: 0.5pt">&nbsp;</TD>
      <TD STYLE="vertical-align: bottom; padding: 0.5pt">&nbsp;</TD>
      <TD STYLE="vertical-align: top; padding: 0.5pt">&nbsp;</TD></TR>
    <TR STYLE="background-color: rgb(204,238,255)">
      <TD STYLE="vertical-align: top; padding: 0.5pt; text-align: center"><FONT STYLE="font-size: 10pt">4.3</FONT></TD>
      <TD STYLE="vertical-align: bottom; padding: 0.5pt">&nbsp;</TD>
      <TD STYLE="vertical-align: top; padding: 0.5pt"><A HREF="http://www.sec.gov/Archives/edgar/data/1359931/000121390020011893/f10q0320ex3-3_artara.htm"><FONT STYLE="font-size: 10pt">Second Certificate of Amendment to the Sixth Amended and Restated Certificate of Incorporation (incorporated by reference to Exhibit 3.3 to the Registrant&rsquo;s Quarterly Report on Form 10-Q, filed with the SEC on May 13, 2020).</FONT></A></TD></TR>
    <TR STYLE="background-color: White">
      <TD STYLE="vertical-align: top; padding: 0.5pt">&nbsp;</TD>
      <TD STYLE="vertical-align: bottom; padding: 0.5pt">&nbsp;</TD>
      <TD STYLE="vertical-align: top; padding: 0.5pt">&nbsp;</TD></TR>
    <TR STYLE="background-color: rgb(204,238,255)">
      <TD STYLE="vertical-align: top; padding: 0.5pt; text-align: center"><FONT STYLE="font-size: 10pt">4.4</FONT></TD>
      <TD STYLE="vertical-align: bottom; padding: 0.5pt">&nbsp;</TD>
      <TD STYLE="vertical-align: top; padding: 0.5pt"><A HREF="http://www.sec.gov/Archives/edgar/data/1359931/000110465920003115/tm201618d1_ex3-2.htm"><FONT STYLE="font-size: 10pt">Certificate of Designation of Preferences, Rights and Limitations of Series 1 Convertible Preferred Stock (incorporated by reference to Exhibit 3.2 to the Registrant&rsquo;s Current Report on Form 8-K, filed with the SEC on January 10, 2020).</FONT></A></TD></TR>
    <TR STYLE="background-color: White">
      <TD STYLE="vertical-align: top; padding: 0.5pt">&nbsp;</TD>
      <TD STYLE="vertical-align: bottom; padding: 0.5pt">&nbsp;</TD>
      <TD STYLE="vertical-align: top; padding: 0.5pt">&nbsp;</TD></TR>
    <TR STYLE="background-color: rgb(204,238,255)">
      <TD STYLE="vertical-align: top; padding: 0.5pt; text-align: center"><FONT STYLE="font-size: 10pt">4.5</FONT></TD>
      <TD STYLE="vertical-align: bottom; padding: 0.5pt">&nbsp;</TD>
      <TD STYLE="vertical-align: top; padding: 0.5pt"><A HREF="http://www.sec.gov/Archives/edgar/data/1359931/000121390020027951/ea127215ex3-1_protara.htm"><FONT STYLE="font-size: 10pt">Certificate of Amendment to the Certificate of Designation of Preferences, Rights and Limitations of Series 1 Convertible Non-Voting Preferred Stock (incorporated by reference to Exhibit 3.1 to the Registrant&rsquo;s Current Report on Form 8-K, filed with the SEC on September 23, 2020).</FONT></A></TD></TR>
    <TR STYLE="background-color: White">
      <TD STYLE="vertical-align: top; padding: 0.5pt; text-align: center">&nbsp;</TD>
      <TD STYLE="vertical-align: bottom; padding: 0.5pt">&nbsp;</TD>
      <TD STYLE="vertical-align: top; padding: 0.5pt">&nbsp;</TD></TR>
    <TR STYLE="background-color: rgb(204,238,255)">
      <TD STYLE="vertical-align: top; padding: 0.5pt; text-align: center"><FONT STYLE="font-size: 10pt">4.6</FONT></TD>
      <TD STYLE="vertical-align: bottom; padding: 0.5pt">&nbsp;</TD>
      <TD STYLE="vertical-align: top; padding: 0.5pt"><A HREF="http://www.sec.gov/Archives/edgar/data/1359931/000117184317004634/exh_32.htm"><FONT STYLE="font-size: 10pt">Second Amended and Restated Bylaws (incorporated by reference to Exhibit 3.2 to the Registrant&rsquo;s Current Report on Form 8-K, filed with the SEC on August 3, 2017).</FONT></A></TD></TR>
    <TR STYLE="background-color: White">
      <TD STYLE="vertical-align: top; padding: 0.5pt; text-align: center">&nbsp;</TD>
      <TD STYLE="vertical-align: bottom; padding: 0.5pt">&nbsp;</TD>
      <TD STYLE="vertical-align: top; padding: 0.5pt">&nbsp;</TD></TR>
    <TR STYLE="background-color: rgb(204,238,255)">
      <TD STYLE="vertical-align: top; padding: 0.5pt; text-align: center"><FONT STYLE="font-size: 10pt">4.7</FONT></TD>
      <TD STYLE="vertical-align: bottom; padding: 0.5pt">&nbsp;</TD>
      <TD STYLE="vertical-align: top; padding: 0.5pt"><FONT STYLE="font-size: 10pt"><A HREF="https://www.sec.gov/Archives/edgar/data/1359931/000104746919005409/a2239754zex-10_5.htm" STYLE="-sec-extract: exhibit">Registration Rights Agreement, dated as of September 23, 2019, by and among the Registrant and the institutional investors named therein (incorporated by reference to Exhibit 10.5 to the Registrant&rsquo;s Current Report on Form 8-K, filed with the SEC on September 24, 2019).</A></FONT></TD></TR>
    <TR STYLE="background-color: White">
      <TD STYLE="vertical-align: top; padding: 0.5pt">&nbsp;</TD>
      <TD STYLE="vertical-align: bottom; padding: 0.5pt">&nbsp;</TD>
      <TD STYLE="vertical-align: top; padding: 0.5pt">&nbsp;</TD></TR>
    <TR STYLE="background-color: rgb(204,238,255)">
      <TD STYLE="vertical-align: top; padding: 0.5pt; text-align: center"><FONT STYLE="font-size: 10pt">4.8</FONT></TD>
      <TD STYLE="vertical-align: bottom; padding: 0.5pt">&nbsp;</TD>
      <TD STYLE="vertical-align: top; padding: 0.5pt"><A HREF="http://www.sec.gov/Archives/edgar/data/1359931/000110465920003115/tm201618d1_ex4-1.htm"><FONT STYLE="font-size: 10pt">Form of Common Stock Certificate (incorporated by reference to Exhibit 4.1 to the Registrant&rsquo;s Current Report on Form 8-K, filed with the SEC on January 10, 2020).</FONT></A></TD></TR>
    <TR STYLE="background-color: White">
      <TD STYLE="vertical-align: top; padding: 0.5pt">&nbsp;</TD>
      <TD STYLE="vertical-align: bottom; padding: 0.5pt">&nbsp;</TD>
      <TD STYLE="vertical-align: top; padding: 0.5pt">&nbsp;</TD></TR>
    <TR STYLE="background-color: rgb(204,238,255)">
      <TD STYLE="vertical-align: top; padding: 0.5pt; text-align: center"><FONT STYLE="font-size: 10pt">5.1*</FONT></TD>
      <TD STYLE="vertical-align: bottom; padding: 0.5pt">&nbsp;</TD>
      <TD STYLE="vertical-align: top; padding: 0.5pt"><FONT STYLE="font-size: 10pt"><U STYLE="text-decoration: none"><A HREF="ea156646ex5-1_protaratherap.htm">Opinion of Cooley LLP.</A></U></FONT></TD></TR>
    <TR STYLE="background-color: White">
      <TD STYLE="vertical-align: top; padding: 0.5pt">&nbsp;</TD>
      <TD STYLE="vertical-align: bottom; padding: 0.5pt">&nbsp;</TD>
      <TD STYLE="vertical-align: top; padding: 0.5pt">&nbsp;</TD></TR>
    <TR STYLE="background-color: rgb(204,238,255)">
      <TD STYLE="vertical-align: top; padding: 0.5pt; text-align: center"><FONT STYLE="font-size: 10pt">23.1*</FONT></TD>
      <TD STYLE="vertical-align: bottom; padding: 0.5pt">&nbsp;</TD>
      <TD STYLE="vertical-align: top; padding: 0.5pt"><FONT STYLE="font-size: 10pt"><U STYLE="text-decoration: none"><A HREF="ea156646ex23-1_protaratherap.htm">Consent of Marcum LLP</A></U></FONT></TD></TR>
    <TR STYLE="background-color: White">
      <TD STYLE="vertical-align: top; padding: 0.5pt; text-align: center">&nbsp;</TD>
      <TD STYLE="vertical-align: bottom; padding: 0.5pt">&nbsp;</TD>
      <TD STYLE="vertical-align: top; padding: 0.5pt"><FONT STYLE="font-size: 10pt">&nbsp;</FONT></TD></TR>
    <TR STYLE="background-color: rgb(204,238,255)">
      <TD STYLE="vertical-align: top; padding: 0.5pt; text-align: center"><FONT STYLE="font-size: 10pt">23.2*</FONT></TD>
      <TD STYLE="vertical-align: bottom; padding: 0.5pt">&nbsp;</TD>
      <TD STYLE="vertical-align: top; padding: 0.5pt"><FONT STYLE="font-size: 10pt; text-decoration: none"><A HREF="ea156646ex23-2_protaratherap.htm">Consent
      of Ernst &amp; Young LLP</A></FONT></TD></TR>
    <TR STYLE="background-color: White">
      <TD STYLE="vertical-align: top; padding: 0.5pt">&nbsp;</TD>
      <TD STYLE="vertical-align: bottom; padding: 0.5pt">&nbsp;</TD>
      <TD STYLE="vertical-align: top; padding: 0.5pt">&nbsp;</TD></TR>
    <TR STYLE="background-color: rgb(204,238,255)">
      <TD STYLE="vertical-align: top; padding: 0.5pt; text-align: center"><FONT STYLE="font-size: 10pt">23.3*</FONT></TD>
      <TD STYLE="vertical-align: bottom; padding: 0.5pt">&nbsp;</TD>
      <TD STYLE="vertical-align: top; padding: 0.5pt"><FONT STYLE="font-size: 10pt"><U STYLE="text-decoration: none"><A HREF="ea156646ex5-1_protaratherap.htm">Consent of Cooley LLP (included in Exhibit 5.1).</A></U></FONT></TD></TR>
    <TR STYLE="background-color: White">
      <TD STYLE="vertical-align: top; padding: 0.5pt">&nbsp;</TD>
      <TD STYLE="vertical-align: bottom; padding: 0.5pt">&nbsp;</TD>
      <TD STYLE="vertical-align: top; padding: 0.5pt">&nbsp;</TD></TR>
    <TR STYLE="background-color: rgb(204,238,255)">
      <TD STYLE="vertical-align: top; padding: 0.5pt; text-align: center"><FONT STYLE="font-size: 10pt">24.1*</FONT></TD>
      <TD STYLE="vertical-align: bottom; padding: 0.5pt">&nbsp;</TD>
      <TD STYLE="vertical-align: top; padding: 0.5pt"><A HREF="#poa_001"><FONT STYLE="font-size: 10pt">Power of Attorney (included on signature page).</FONT></A></TD></TR>
    <TR STYLE="background-color: White">
      <TD STYLE="vertical-align: top; padding: 0.5pt">&nbsp;</TD>
      <TD STYLE="vertical-align: bottom; padding: 0.5pt">&nbsp;</TD>
      <TD STYLE="vertical-align: top; padding: 0.5pt">&nbsp;</TD></TR>
    <TR STYLE="background-color: rgb(204,238,255)">
      <TD STYLE="vertical-align: top; padding: 0.5pt; text-align: center"><FONT STYLE="font-size: 10pt">99.1</FONT></TD>
      <TD STYLE="vertical-align: bottom; padding: 0.5pt">&nbsp;</TD>
      <TD STYLE="vertical-align: top; padding: 0.5pt"><A HREF="http://www.sec.gov/Archives/edgar/data/1359931/000110465920003115/tm201618d1_ex10-1.htm"><FONT STYLE="font-size: 10pt">Amended and Restated 2014 Equity Incentive Plan of the Registrant, as amended (incorporated by reference to Exhibit 10.1 to the Registrant&rsquo;s Current Report on Form 8-K, filed on January 10, 2020).</FONT></A></TD></TR>
    <TR STYLE="background-color: White">
      <TD STYLE="vertical-align: top; padding: 0.5pt">&nbsp;</TD>
      <TD STYLE="vertical-align: bottom; padding: 0.5pt">&nbsp;</TD>
      <TD STYLE="vertical-align: top; padding: 0.5pt">&nbsp;</TD></TR>
    <TR STYLE="background-color: rgb(204,238,255)">
      <TD STYLE="vertical-align: top; padding: 0.5pt; text-align: center"><FONT STYLE="font-size: 10pt">99.2</FONT></TD>
      <TD STYLE="vertical-align: bottom; padding: 0.5pt">&nbsp;</TD>
      <TD STYLE="vertical-align: top; padding: 0.5pt"><A HREF="http://www.sec.gov/Archives/edgar/data/1359931/000117184320001860/exh_1025.htm"><FONT STYLE="font-size: 10pt">Forms of Stock Option Agreement, Option Exercise, Restricted Stock Unit Grant and Restricted Stock Unit Agreement under the Amended and Restated 2014 Equity Incentive Plan of the Registrant, as amended (incorporated by reference to Exhibit 10.25 to the Registrant&rsquo;s Annual Report on form 10-K for the fiscal year ended December 31, 2019 filed on March 20, 2020).</FONT></A></TD></TR>
    <TR STYLE="background-color: White">
      <TD STYLE="vertical-align: top; padding: 0.5pt">&nbsp;</TD>
      <TD STYLE="vertical-align: bottom; padding: 0.5pt">&nbsp;</TD>
      <TD STYLE="vertical-align: top; padding: 0.5pt">&nbsp;</TD></TR>
    <TR STYLE="background-color: rgb(204,238,255)">
      <TD STYLE="vertical-align: top; padding: 0.5pt; text-align: center"><FONT STYLE="font-size: 10pt">99.3</FONT></TD>
      <TD STYLE="vertical-align: bottom; padding: 0.5pt">&nbsp;</TD>
      <TD STYLE="vertical-align: top; padding: 0.5pt"><A HREF="http://www.sec.gov/Archives/edgar/data/1359931/000104746914008146/a2221509zex-10_25.htm"><FONT STYLE="font-size: 10pt">2014 Employee Stock Purchase Plan (incorporated by reference to Exhibit 10.25 to Amendment No. 1 to the Company&rsquo;s Registration Statement on Form S-1 filed on October 7, 2014).</FONT></A></TD></TR>
    <TR STYLE="background-color: White">
      <TD STYLE="vertical-align: top; padding: 0.5pt; text-align: center">&nbsp;</TD>
      <TD STYLE="vertical-align: bottom; padding: 0.5pt">&nbsp;</TD>
      <TD STYLE="vertical-align: top; padding: 0.5pt">&nbsp;</TD></TR>
    <TR STYLE="background-color: rgb(204,238,255)">
      <TD STYLE="vertical-align: top; padding: 0.5pt; text-align: center"><FONT STYLE="font-size: 10pt">107*</FONT></TD>
      <TD STYLE="vertical-align: bottom; padding: 0.5pt">&nbsp;</TD>
      <TD STYLE="vertical-align: top; padding: 0.5pt"><FONT STYLE="font-size: 10pt"><A HREF="ea156646ex-fee_protaratherap.htm">Filing Fee Table</A></FONT></TD></TR>
    </TABLE>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.25in; text-indent: -0.25in"></P>
  
  <!-- Field: Rule-Page --><DIV STYLE="margin-top: 0; margin-bottom: 0; width: 25%"><DIV STYLE="font-size: 1pt; border-top: Black 1.5pt solid">&nbsp;</DIV></DIV><!-- Field: /Rule-Page -->
  
  <TABLE CELLPADDING="0" CELLSPACING="0" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 0; width: 100%"><TR STYLE="vertical-align: top; text-align: justify">
  <TD STYLE="width: 0%"></TD><TD STYLE="width: 0.25in; text-align: left">*</TD><TD STYLE="text-align: justify">Filed herewith.</TD>
  </TR></TABLE>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>&nbsp;</B></P>
  
  <!-- Field: Page; Sequence: 4; Value: 1 -->
      <DIV STYLE="margin-top: 12pt; margin-bottom: 6pt; border-bottom: Black 1.5pt solid"><P STYLE="font: 10pt Times New Roman, Times, Serif; text-align: center; margin-top: 0pt; margin-bottom: 0pt">II-<!-- Field: Sequence; Type: Arabic; Name: PageNo -->2<!-- Field: /Sequence --></P></DIV>
      <DIV STYLE="break-before: page; margin-top: 6pt; margin-bottom: 12pt"><P STYLE="margin: 0pt">&nbsp;</P></DIV>
      <!-- Field: /Page -->
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>&nbsp;</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>SIGNATURES</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">Pursuant to the requirements of the Securities
  Act, the Registrant certifies that it has reasonable grounds to believe that it meets all of the requirements for filing on Form S-8 and
  has duly caused this Registration Statement to be signed on its behalf by the undersigned, thereunto duly authorized, in the City of New
  York, State of New York on March 9, 2022.</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&nbsp;</P>
  
  <TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
    <TR STYLE="vertical-align: top">
      <TD>&nbsp;</TD>
      <TD COLSPAN="2"><FONT STYLE="font-size: 10pt"><B>PROTARA THERAPEUTICS, INC.</B></FONT></TD></TR>
    <TR STYLE="vertical-align: top">
      <TD STYLE="width: 60%">&nbsp;</TD>
      <TD STYLE="width: 4%">&nbsp;</TD>
      <TD STYLE="width: 36%">&nbsp;</TD></TR>
    <TR STYLE="vertical-align: top">
      <TD STYLE="padding-bottom: 1.5pt">&nbsp;</TD>
      <TD STYLE="padding-bottom: 1.5pt"><FONT STYLE="font-size: 10pt">By:</FONT></TD>
      <TD STYLE="border-bottom: Black 1.5pt solid"><FONT STYLE="font-size: 10pt">/s/ Jesse Shefferman</FONT></TD></TR>
    <TR STYLE="vertical-align: top">
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD><FONT STYLE="font-size: 10pt">Jesse Shefferman</FONT></TD></TR>
    <TR STYLE="vertical-align: top">
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD><FONT STYLE="font-size: 10pt">President and Chief Executive Officer</FONT></TD></TR>
    </TABLE>
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B><A NAME="poa_001"></A>POWER OF ATTORNEY</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in"><B>KNOW ALL PERSONS BY THESE PRESENTS</B>, that
  each person whose signature appears below constitutes and appoints Jesse Shefferman, Blaine Davis and Mary J. Grendell, as his or her
  true and lawful attorney-in-fact and agent, with full power of substitution and resubstitution, for him or her and in his or her name,
  place and stead, in any and all capacities, to sign any and all amendments to this Registration Statement, and to file the same, with
  all exhibits thereto, and other documents in connection therewith, with the Securities and Exchange Commission, granting unto said attorney-in-fact
  and agent full power and authority to do and perform each and every act and thing requisite and necessary to be done in connection therewith,
  as fully to all intents and purposes as he or she might or could do in person, hereby ratifying and confirming all that said attorney-in-fact
  and agent or his substitute or substitutes, may lawfully do or cause to be done by virtue hereof.</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">Pursuant to the requirements of the Securities
  Act of 1933, this Registration Statement has been signed by the following persons in the capacities and on the date indicated.</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&nbsp;</P>
  
  <TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
    <TR STYLE="vertical-align: top">
      <TD STYLE="width: 38%; border-bottom: black 1.5pt solid; padding: 0.25pt 0.25pt 0.75pt; text-align: center"><FONT STYLE="font-size: 10pt"><B>Signature</B></FONT></TD>
      <TD STYLE="width: 2%; padding: 0.25pt 0.25pt 1.75pt; text-align: center">&nbsp;</TD>
      <TD STYLE="width: 38%; border-bottom: black 1.5pt solid; padding: 0.25pt 0.25pt 0.75pt; text-align: center"><FONT STYLE="font-size: 10pt"><B>Title</B></FONT></TD>
      <TD STYLE="width: 2%; padding: 0.25pt 0.25pt 1.75pt; text-align: center">&nbsp;</TD>
      <TD STYLE="width: 20%; border-bottom: black 1.5pt solid; padding: 0.25pt 0.25pt 0.75pt; text-align: center"><FONT STYLE="font-size: 10pt"><B>Date</B></FONT></TD></TR>
    <TR STYLE="vertical-align: top">
      <TD STYLE="padding: 0.25pt; text-align: center">&nbsp;</TD>
      <TD STYLE="padding: 0.25pt; text-align: center">&nbsp;</TD>
      <TD STYLE="padding: 0.25pt; text-align: center">&nbsp;</TD>
      <TD STYLE="padding: 0.25pt; text-align: center">&nbsp;</TD>
      <TD STYLE="padding: 0.25pt; text-align: center">&nbsp;</TD></TR>
    <TR STYLE="vertical-align: top">
      <TD STYLE="border-bottom: black 1.5pt solid; padding: 0.25pt 0.25pt 0.75pt; text-align: center"><FONT STYLE="font-size: 10pt">/s/ Jesse Shefferman</FONT></TD>
      <TD STYLE="padding: 0.25pt; text-align: center">&nbsp;</TD>
      <TD STYLE="padding: 0.25pt; text-align: center"><FONT STYLE="font-size: 10pt">President and Chief Executive Officer and Director</FONT></TD>
      <TD STYLE="padding: 0.25pt; text-align: center">&nbsp;</TD>
      <TD STYLE="padding: 0.25pt; text-align: center"><FONT STYLE="font-size: 10pt">March 9, 2022</FONT></TD></TR>
    <TR STYLE="vertical-align: top">
      <TD STYLE="padding: 0.25pt; text-align: center"><FONT STYLE="font-size: 10pt">Jesse Shefferman</FONT></TD>
      <TD STYLE="padding: 0.25pt; text-align: center">&nbsp;</TD>
      <TD STYLE="padding: 0.25pt; text-align: center"><FONT STYLE="font-size: 10pt"><I>(Principal Executive Officer)</I></FONT></TD>
      <TD STYLE="padding: 0.25pt; text-align: center">&nbsp;</TD>
      <TD STYLE="padding: 0.25pt; text-align: center">&nbsp;</TD></TR>
    <TR STYLE="vertical-align: top">
      <TD STYLE="padding: 0.25pt; text-align: center">&nbsp;</TD>
      <TD STYLE="padding: 0.25pt; text-align: center">&nbsp;</TD>
      <TD STYLE="padding: 0.25pt; text-align: center">&nbsp;</TD>
      <TD STYLE="padding: 0.25pt; text-align: center">&nbsp;</TD>
      <TD STYLE="padding: 0.25pt; text-align: center">&nbsp;</TD></TR>
    <TR STYLE="vertical-align: top">
      <TD STYLE="border-bottom: black 1.5pt solid; padding: 0.25pt 0.25pt 0.75pt; text-align: center"><FONT STYLE="font-size: 10pt">/s/ Blaine Davis</FONT></TD>
      <TD STYLE="padding: 0.25pt; text-align: center">&nbsp;</TD>
      <TD STYLE="padding: 0.25pt; text-align: center"><FONT STYLE="font-size: 10pt">Chief Financial Officer</FONT></TD>
      <TD STYLE="padding: 0.25pt; text-align: center">&nbsp;</TD>
      <TD STYLE="padding: 0.25pt; text-align: center"><FONT STYLE="font-size: 10pt">March 9, 2022</FONT></TD></TR>
    <TR STYLE="vertical-align: top">
      <TD STYLE="padding: 0.25pt; text-align: center"><FONT STYLE="font-size: 10pt">Blaine Davis</FONT></TD>
      <TD STYLE="padding: 0.25pt; text-align: center">&nbsp;</TD>
      <TD STYLE="padding: 0.25pt; text-align: center"><FONT STYLE="font-size: 10pt"><I>(Principal Financial and Accounting Officer)</I></FONT></TD>
      <TD STYLE="padding: 0.25pt; text-align: center">&nbsp;</TD>
      <TD STYLE="padding: 0.25pt; text-align: center">&nbsp;</TD></TR>
    <TR STYLE="vertical-align: top">
      <TD STYLE="padding: 0.25pt; text-align: center">&nbsp;</TD>
      <TD STYLE="padding: 0.25pt; text-align: center">&nbsp;</TD>
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      <TD STYLE="padding: 0.25pt; text-align: center">&nbsp;</TD>
      <TD STYLE="padding: 0.25pt; text-align: center">&nbsp;</TD></TR>
    <TR STYLE="vertical-align: top">
      <TD STYLE="border-bottom: black 1.5pt solid; padding: 0.25pt 0.25pt 0.75pt; text-align: center"><FONT STYLE="font-size: 10pt">/s/ Luke Beshar</FONT></TD>
      <TD STYLE="padding: 0.25pt; text-align: center">&nbsp;</TD>
      <TD STYLE="padding: 0.25pt; text-align: center"><FONT STYLE="font-size: 10pt">Chairman of the Board of Directors</FONT></TD>
      <TD STYLE="padding: 0.25pt; text-align: center">&nbsp;</TD>
      <TD STYLE="padding: 0.25pt; text-align: center"><FONT STYLE="font-size: 10pt">March 9, 2022</FONT></TD></TR>
    <TR STYLE="vertical-align: top">
      <TD STYLE="padding: 0.25pt; text-align: center"><FONT STYLE="font-size: 10pt">Luke Beshar</FONT></TD>
      <TD STYLE="padding: 0.25pt; text-align: center">&nbsp;</TD>
      <TD STYLE="padding: 0.25pt; text-align: center">&nbsp;</TD>
      <TD STYLE="padding: 0.25pt; text-align: center">&nbsp;</TD>
      <TD STYLE="padding: 0.25pt; text-align: center">&nbsp;</TD></TR>
    <TR STYLE="vertical-align: top">
      <TD STYLE="padding: 0.25pt; text-align: center">&nbsp;</TD>
      <TD STYLE="padding: 0.25pt; text-align: center">&nbsp;</TD>
      <TD STYLE="padding: 0.25pt; text-align: center">&nbsp;</TD>
      <TD STYLE="padding: 0.25pt; text-align: center">&nbsp;</TD>
      <TD STYLE="padding: 0.25pt; text-align: center">&nbsp;</TD></TR>
    <TR STYLE="vertical-align: top">
      <TD STYLE="border-bottom: black 1.5pt solid; padding: 0.25pt 0.25pt 0.75pt; text-align: center"><FONT STYLE="font-size: 10pt">/s/ Barry Flannelly, Pharm.D.</FONT></TD>
      <TD STYLE="padding: 0.25pt; text-align: center">&nbsp;</TD>
      <TD STYLE="padding: 0.25pt; text-align: center"><FONT STYLE="font-size: 10pt">Director</FONT></TD>
      <TD STYLE="padding: 0.25pt; text-align: center">&nbsp;</TD>
      <TD STYLE="padding: 0.25pt; text-align: center"><FONT STYLE="font-size: 10pt">March 9, 2022</FONT></TD></TR>
    <TR STYLE="vertical-align: top">
      <TD STYLE="padding: 0.25pt; text-align: center"><FONT STYLE="font-size: 10pt">Barry Flannelly, Pharm.D.</FONT></TD>
      <TD STYLE="padding: 0.25pt; text-align: center">&nbsp;</TD>
      <TD STYLE="padding: 0.25pt; text-align: center">&nbsp;</TD>
      <TD STYLE="padding: 0.25pt; text-align: center">&nbsp;</TD>
      <TD STYLE="padding: 0.25pt; text-align: center">&nbsp;</TD></TR>
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      <TD STYLE="padding: 0.25pt; text-align: center">&nbsp;</TD>
      <TD STYLE="padding: 0.25pt; text-align: center">&nbsp;</TD>
      <TD STYLE="padding: 0.25pt; text-align: center">&nbsp;</TD>
      <TD STYLE="padding: 0.25pt; text-align: center">&nbsp;</TD>
      <TD STYLE="padding: 0.25pt; text-align: center">&nbsp;</TD></TR>
    <TR STYLE="vertical-align: top">
      <TD STYLE="border-bottom: black 1.5pt solid; padding: 0.25pt 0.25pt 0.75pt; text-align: center"><FONT STYLE="font-size: 10pt">/s/ Roger Garceau, M.D.</FONT></TD>
      <TD STYLE="padding: 0.25pt; text-align: center">&nbsp;</TD>
      <TD STYLE="padding: 0.25pt; text-align: center"><FONT STYLE="font-size: 10pt">Director</FONT></TD>
      <TD STYLE="padding: 0.25pt; text-align: center">&nbsp;</TD>
      <TD STYLE="padding: 0.25pt; text-align: center"><FONT STYLE="font-size: 10pt">March 9, 2022</FONT></TD></TR>
    <TR STYLE="vertical-align: top">
      <TD STYLE="padding: 0.25pt; text-align: center"><FONT STYLE="font-size: 10pt">Roger Garceau, M.D.</FONT></TD>
      <TD STYLE="padding: 0.25pt; text-align: center">&nbsp;</TD>
      <TD STYLE="padding: 0.25pt; text-align: center">&nbsp;</TD>
      <TD STYLE="padding: 0.25pt; text-align: center">&nbsp;</TD>
      <TD STYLE="padding: 0.25pt; text-align: center">&nbsp;</TD></TR>
  
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      <TD STYLE="padding: 0.25pt; text-align: center">&nbsp;</TD>
      <TD STYLE="padding: 0.25pt; text-align: center">&nbsp;</TD></TR>
    <TR STYLE="vertical-align: top">
      <TD STYLE="border-bottom: black 1.5pt solid; padding: 0.25pt 0.25pt 0.75pt; text-align: center"><FONT STYLE="font-size: 10pt">/s/ Jane Huang, M.D.</FONT></TD>
      <TD STYLE="padding: 0.25pt; text-align: center">&nbsp;</TD>
      <TD STYLE="padding: 0.25pt; text-align: center"><FONT STYLE="font-size: 10pt">Director</FONT></TD>
      <TD STYLE="padding: 0.25pt; text-align: center">&nbsp;</TD>
      <TD STYLE="padding: 0.25pt; text-align: center"><FONT STYLE="font-size: 10pt">March 9, 2022</FONT></TD></TR>
    <TR STYLE="vertical-align: top">
      <TD STYLE="padding: 0.25pt; text-align: center"><FONT STYLE="font-size: 10pt">Jane Huang, M.D.</FONT></TD>
      <TD STYLE="padding: 0.25pt; text-align: center">&nbsp;</TD>
      <TD STYLE="padding: 0.25pt; text-align: center">&nbsp;</TD>
      <TD STYLE="padding: 0.25pt; text-align: center">&nbsp;</TD>
      <TD STYLE="padding: 0.25pt; text-align: center">&nbsp;</TD></TR>
  
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    <TR STYLE="vertical-align: top">
      <TD STYLE="border-bottom: black 1.5pt solid; padding: 0.25pt 0.25pt 0.75pt; text-align: center"><FONT STYLE="font-size: 10pt">/s/ Richard Levy, M.D.</FONT></TD>
      <TD STYLE="padding: 0.25pt; text-align: center">&nbsp;</TD>
      <TD STYLE="padding: 0.25pt; text-align: center"><FONT STYLE="font-size: 10pt">Director</FONT></TD>
      <TD STYLE="padding: 0.25pt; text-align: center">&nbsp;</TD>
      <TD STYLE="padding: 0.25pt; text-align: center"><FONT STYLE="font-size: 10pt">March 9, 2022</FONT></TD></TR>
    <TR STYLE="vertical-align: top">
      <TD STYLE="padding: 0.25pt; text-align: center"><FONT STYLE="font-size: 10pt">Richard Levy, M.D.</FONT></TD>
      <TD STYLE="padding: 0.25pt; text-align: center">&nbsp;</TD>
      <TD STYLE="padding: 0.25pt; text-align: center">&nbsp;</TD>
      <TD STYLE="padding: 0.25pt; text-align: center">&nbsp;</TD>
      <TD STYLE="padding: 0.25pt; text-align: center">&nbsp;</TD></TR>
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      <TD STYLE="padding: 0.25pt; text-align: center">&nbsp;</TD>
      <TD STYLE="padding: 0.25pt; text-align: center">&nbsp;</TD></TR>
    <TR STYLE="vertical-align: top">
      <TD STYLE="border-bottom: black 1.5pt solid; padding: 0.25pt 0.25pt 0.75pt; text-align: center"><FONT STYLE="font-size: 10pt">/s/ Gregory P. Sargen</FONT></TD>
      <TD STYLE="padding: 0.25pt; text-align: center">&nbsp;</TD>
      <TD STYLE="padding: 0.25pt; text-align: center"><FONT STYLE="font-size: 10pt">Director</FONT></TD>
      <TD STYLE="padding: 0.25pt; text-align: center">&nbsp;</TD>
      <TD STYLE="padding: 0.25pt; text-align: center"><FONT STYLE="font-size: 10pt">March 9, 2022</FONT></TD></TR>
    <TR STYLE="vertical-align: top">
      <TD STYLE="padding: 0.25pt; text-align: center"><FONT STYLE="font-size: 10pt">Gregory P. Sargen</FONT></TD>
      <TD STYLE="padding: 0.25pt; text-align: center">&nbsp;</TD>
      <TD STYLE="padding: 0.25pt; text-align: center">&nbsp;</TD>
      <TD STYLE="padding: 0.25pt; text-align: center">&nbsp;</TD>
      <TD STYLE="padding: 0.25pt; text-align: center">&nbsp;</TD></TR>
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      <TD STYLE="padding: 0.25pt; text-align: center">&nbsp;</TD>
      <TD STYLE="padding: 0.25pt; text-align: center">&nbsp;</TD>
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      <TD STYLE="padding: 0.25pt; text-align: center">&nbsp;</TD>
      <TD STYLE="padding: 0.25pt; text-align: center">&nbsp;</TD></TR>
    <TR STYLE="vertical-align: top">
      <TD STYLE="border-bottom: black 1.5pt solid; padding: 0.25pt 0.25pt 0.75pt; text-align: center"><FONT STYLE="font-size: 10pt">/s/ Cynthia Smith</FONT></TD>
      <TD STYLE="padding: 0.25pt; text-align: center">&nbsp;</TD>
      <TD STYLE="padding: 0.25pt; text-align: center"><FONT STYLE="font-size: 10pt">Director</FONT></TD>
      <TD STYLE="padding: 0.25pt; text-align: center">&nbsp;</TD>
      <TD STYLE="padding: 0.25pt; text-align: center"><FONT STYLE="font-size: 10pt">March 9, 2022</FONT></TD></TR>
    <TR STYLE="vertical-align: top">
      <TD STYLE="padding: 0.25pt; text-align: center"><FONT STYLE="font-size: 10pt">Cynthia Smith</FONT></TD>
      <TD STYLE="padding: 0.25pt; text-align: center">&nbsp;</TD>
      <TD STYLE="padding: 0.25pt; text-align: center">&nbsp;</TD>
      <TD STYLE="padding: 0.25pt; text-align: center">&nbsp;</TD>
      <TD STYLE="padding: 0.25pt; text-align: center">&nbsp;</TD></TR>
    <TR STYLE="vertical-align: top">
      <TD STYLE="padding: 0.25pt; text-align: center">&nbsp;</TD>
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      <TD STYLE="padding: 0.25pt; text-align: center">&nbsp;</TD>
      <TD STYLE="padding: 0.25pt; text-align: center">&nbsp;</TD></TR>
    <TR STYLE="vertical-align: top">
      <TD STYLE="border-bottom: black 1.5pt solid; padding: 0.25pt 0.25pt 0.75pt; text-align: center"><FONT STYLE="font-size: 10pt">/s/ Michael Solomon, Ph.D.</FONT></TD>
      <TD STYLE="padding: 0.25pt; text-align: center">&nbsp;</TD>
      <TD STYLE="padding: 0.25pt; text-align: center"><FONT STYLE="font-size: 10pt">Director</FONT></TD>
      <TD STYLE="padding: 0.25pt; text-align: center">&nbsp;</TD>
      <TD STYLE="padding: 0.25pt; text-align: center"><FONT STYLE="font-size: 10pt">March 9, 2022</FONT></TD></TR>
    <TR STYLE="vertical-align: top">
      <TD STYLE="padding: 0.25pt; text-align: center"><FONT STYLE="font-size: 10pt">Michael Solomon, Ph.D.</FONT></TD>
      <TD STYLE="padding: 0.25pt; text-align: center">&nbsp;</TD>
      <TD STYLE="padding: 0.25pt; text-align: center">&nbsp;</TD>
      <TD STYLE="padding: 0.25pt; text-align: center">&nbsp;</TD>
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metadata_documents: [{"type": "S-8", "sequence": "1", "filename": "ea156646-s8_protaratherap.htm", "description": "REGISTRATION STATEMENT", "secsgml_size_bytes": 57172}]
metadata_filer: {"company-data": {"conformed-name": "Protara Therapeutics, Inc.", "cik": "0001359931", "assigned-sic": "2836", "irs-number": "204580525", "fiscal-year-end": "1231"}, "filing-values": {"form-type": "S-8", "act": "33", "file-number": "333-263392", "film-number": "22725501"}, "business-address": {"street1": "345 PARK AVENUE SOUTH", "street2": "3RD FLOOR", "city": "NEW YORK", "state": "NY", "zip": "10010", "phone": "646-844-0337"}, "mail-address": {"street1": "345 PARK AVENUE SOUTH", "street2": "3RD FLOOR", "city": "NEW YORK", "state": "NY", "zip": "10010"}, "former-company": [{"former-conformed-name": "ArTara Therapeutics, Inc.", "date-changed": "20200110"}, {"former-conformed-name": "PROTEON THERAPEUTICS INC", "date-changed": "20060420"}]}
text: As filed with the Securities and Exchange Commission
  on March 9, 2022
  Registration No. 333-
  UNITED STATES
  SECURITIES AND EXCHANGE COMMISSION
  Washington, D.C. 20549
  FORM S-8
  REGISTRATION STATEMENT UNDER THE SECURITIES
  ACT OF 1933
  Protara Therapeutics, Inc.
  (Exact name of registrant as specified in its charter)
  Delaware
  20-4580525
  (State or other jurisdiction of
  incorporation or organization)
  (I.R.S. Employer
  Identification No.)
  345 Park Avenue South, Third Floor
  New York, NY 10010
  (Address of Principal Executive Offices) (Zip Code)
  Amended and Restated 2014 Equity Incentive Plan,
  as amended
  2014 Employee Stock Purchase Plan
  (Full title of the plans)
  Jesse Shefferman
  President and Chief Executive Officer
  Protara Therapeutics, Inc.
  345 Park Avenue South, Third Floor
  New York, NY 10010
  (Name and address of agent for service)
  (646) 844-0337
  (Telephone number, including area code, of agent
  for service)
  Copies to:
  Mary J. Grendell, Esq.
  General Counsel and Corporate Secretary
  Ryan S. Sansom, Esq.
  Protara Therapeutics, Inc.
  Karen E. Deschaine, Esq.
  345 Park Avenue South, Third Floor
  Cooley LLP
  New York, NY 10010
  4401 Eastgate Mall
  (646) 844-0337
  San Diego, California 92121
  (858) 550-6000
  Indicate by check mark whether the registrant is a large accelerated
  filer, an accelerated filer, a non-accelerated filer, a smaller reporting company or an emerging growth company. See the definitions of
  "large accelerated filer," "accelerated filer," "smaller reporting company" and "emerging growth
  company" in Rule 12b-2 of the Exchange Act.
  Large accelerated filer
  ☐
  Accelerated filer
  ☐
  Non-accelerated filer
  ☒
  Smaller reporting company
  ☒
  Emerging growth company
  ☐
  If an emerging growth company, indicate by check mark if the registrant
  has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant
  to Section 7(a)(2)(B) of the Securities Act.
  ☐
  PART I
  EXPLANATORY NOTE
  Protara Therapeutics, Inc. (the "Registrant") is filing
  this Registration Statement on Form S-8 (the "Registration Statement") for the purpose of registering an additional 840,181
  shares of common stock under the Registrant's Amended and Restated 2014 Equity Incentive Plan, as amended (the "EIP"),
  and an additional 7,025 shares of common stock under the Registrant's 2014 Employee Stock Purchase Plan (the "ESPP"),
  pursuant to the "evergreen" provisions of each plan which provide for annual automatic increases in the number of shares of
  the Registrant's common stock (the "Common Stock") reserved for issuance under each respective plan.
  1
  PART II
  INFORMATION REQUIRED IN THE REGISTRATION STATEMENT
  ITEM 3. Incorporation of Documents by Reference.
  This Registration Statement is being filed for
  the purpose of increasing the number of securities of the same class as other securities for which Registration Statements of the Registrant
  on Form S-8 relating to the same employee benefit plan are effective. The Registrant previously registered shares of its Common Stock
  for issuance under the EIP and ESPP under Registration Statements on Form S-8 filed with the Securities and Exchange Commission (the "SEC")
  on
  November 25, 2014
  (File No. 333-200587),
  January 4, 2018
  (File No. 333-222415),
  January 3, 2019
  (File No. 333-229123),
  January 15, 2020
  (File No. 333-235918) and
  March 11, 2021
  (File No. 333-254124). Pursuant to General Instruction E to Form S-8, this Registration
  Statement hereby incorporates by reference the contents of the Registration Statements referenced above.
  The registrant hereby incorporates by reference
  into this Registration Statement the following documents previously filed by the registrant with the SEC (other than portions of Current
  Reports furnished under Item 2.02 or Item 7.01 of Form 8-K and exhibits related to such items or other portions of documents filed with
  the SEC which were furnished, but not filed, pursuant to applicable rules promulgated by the SEC):
  ●
  the Company's Annual Report on Form 10-K filed with the SEC on
  March 9, 2022
  ;
  ●
  the Company's Current Report on Form 8-K filed with the SEC on
  January
  10, 2022
  ; and
  ●
  the description of the Company's Common Stock contained in the
  Company's Registration Statement on
  Form
  8-A (File No. 001-36694) filed with the SEC on October 16, 2014
  under the Securities Exchange Act of 1934, as amended (the "Exchange Act"),
  including any amendments or reports filed for the purpose of updating such description.
  In addition, all reports and other documents subsequently
  filed by the registrant pursuant to Sections 13(a), 13(c), 14 and 15(d) of the Exchange Act, other than Current Reports furnished under
  Item 2.02 or Item 7.01 of Form 8-K and exhibits furnished on such form that relate to such items, prior to the filing of a post-effective
  amendment which indicates that all securities offered have been sold or which deregisters all securities then remaining unsold, shall
  be deemed to be incorporated by reference herein and to be a part of this Registration Statement from the date of the filing of such reports
  and documents. Any statement contained in a document incorporated or deemed to be incorporated by reference herein shall be deemed to
  be modified or superseded for purposes of this Registration Statement to the extent that a statement herein or in any subsequently filed
  document which also is or is deemed to be incorporated by reference herein modifies or supersedes such statement. Any such statement so
  modified or superseded shall not constitute a part of this Registration Statement, except as so modified or superseded.
  II-
  1
  ITEM 8. EXHIBITS.
  Exhibit
  Number
  Description
  4.1
  Sixth Amended and Restated Certificate of Incorporation (incorporated by reference to Exhibit 3.1 to the Registrant's Current Report on Form 8-K, filed with the SEC on October 27, 2014).
  4.2
  Certificate of Amendment to the Sixth Amended and Restated Certificate of Incorporation (incorporated by reference to Exhibit 3.1 to the Registrant's Current Report on Form 8-K, filed with the SEC on January 10, 2020).
  4.3
  Second Certificate of Amendment to the Sixth Amended and Restated Certificate of Incorporation (incorporated by reference to Exhibit 3.3 to the Registrant's Quarterly Report on Form 10-Q, filed with the SEC on May 13, 2020).
  4.4
  Certificate of Designation of Preferences, Rights and Limitations of Series 1 Convertible Preferred Stock (incorporated by reference to Exhibit 3.2 to the Registrant's Current Report on Form 8-K, filed with the SEC on January 10, 2020).
  4.5
  Certificate of Amendment to the Certificate of Designation of Preferences, Rights and Limitations of Series 1 Convertible Non-Voting Preferred Stock (incorporated by reference to Exhibit 3.1 to the Registrant's Current Report on Form 8-K, filed with the SEC on September 23, 2020).
  4.6
  Second Amended and Restated Bylaws (incorporated by reference to Exhibit 3.2 to the Registrant's Current Report on Form 8-K, filed with the SEC on August 3, 2017).
  4.7
  Registration Rights Agreement, dated as of September 23, 2019, by and among the Registrant and the institutional investors named therein (incorporated by reference to Exhibit 10.5 to the Registrant's Current Report on Form 8-K, filed with the SEC on September 24, 2019).
  4.8
  Form of Common Stock Certificate (incorporated by reference to Exhibit 4.1 to the Registrant's Current Report on Form 8-K, filed with the SEC on January 10, 2020).
  5.1*
  Opinion of Cooley LLP.
  23.1*
  Consent of Marcum LLP
  23.2*
  Consent
      of Ernst & Young LLP
  23.3*
  Consent of Cooley LLP (included in Exhibit 5.1).
  24.1*
  Power of Attorney (included on signature page).
  99.1
  Amended and Restated 2014 Equity Incentive Plan of the Registrant, as amended (incorporated by reference to Exhibit 10.1 to the Registrant's Current Report on Form 8-K, filed on January 10, 2020).
  99.2
  Forms of Stock Option Agreement, Option Exercise, Restricted Stock Unit Grant and Restricted Stock Unit Agreement under the Amended and Restated 2014 Equity Incentive Plan of the Registrant, as amended (incorporated by reference to Exhibit 10.25 to the Registrant's Annual Report on form 10-K for the fiscal year ended December 31, 2019 filed on March 20, 2020).
  99.3
  2014 Employee Stock Purchase Plan (incorporated by reference to Exhibit 10.25 to Amendment No. 1 to the Company's Registration Statement on Form S-1 filed on October 7, 2014).
  107*
  Filing Fee Table
  *
  Filed herewith.
  II-
  2
  SIGNATURES
  Pursuant to the requirements of the Securities
  Act, the Registrant certifies that it has reasonable grounds to believe that it meets all of the requirements for filing on Form S-8 and
  has duly caused this Registration Statement to be signed on its behalf by the undersigned, thereunto duly authorized, in the City of New
  York, State of New York on March 9, 2022.
  PROTARA THERAPEUTICS, INC.
  By:
  /s/ Jesse Shefferman
  Jesse Shefferman
  President and Chief Executive Officer
  POWER OF ATTORNEY
  KNOW ALL PERSONS BY THESE PRESENTS
  , that
  each person whose signature appears below constitutes and appoints Jesse Shefferman, Blaine Davis and Mary J. Grendell, as his or her
  true and lawful attorney-in-fact and agent, with full power of substitution and resubstitution, for him or her and in his or her name,
  place and stead, in any and all capacities, to sign any and all amendments to this Registration Statement, and to file the same, with
  all exhibits thereto, and other documents in connection therewith, with the Securities and Exchange Commission, granting unto said attorney-in-fact
  and agent full power and authority to do and perform each and every act and thing requisite and necessary to be done in connection therewith,
  as fully to all intents and purposes as he or she might or could do in person, hereby ratifying and confirming all that said attorney-in-fact
  and agent or his substitute or substitutes, may lawfully do or cause to be done by virtue hereof.
  Pursuant to the requirements of the Securities
  Act of 1933, this Registration Statement has been signed by the following persons in the capacities and on the date indicated.
  Signature
  Title
  Date
  /s/ Jesse Shefferman
  President and Chief Executive Officer and Director
  March 9, 2022
  Jesse Shefferman
  (Principal Executive Officer)
  /s/ Blaine Davis
  Chief Financial Officer
  March 9, 2022
  Blaine Davis
  (Principal Financial and Accounting Officer)
  /s/ Luke Beshar
  Chairman of the Board of Directors
  March 9, 2022
  Luke Beshar
  /s/ Barry Flannelly, Pharm.D.
  Director
  March 9, 2022
  Barry Flannelly, Pharm.D.
  /s/ Roger Garceau, M.D.
  Director
  March 9, 2022
  Roger Garceau, M.D.
  /s/ Jane Huang, M.D.
  Director
  March 9, 2022
  Jane Huang, M.D.
  /s/ Richard Levy, M.D.
  Director
  March 9, 2022
  Richard Levy, M.D.
  /s/ Gregory P. Sargen
  Director
  March 9, 2022
  Gregory P. Sargen
  /s/ Cynthia Smith
  Director
  March 9, 2022
  Cynthia Smith
  /s/ Michael Solomon, Ph.D.
  Director
  March 9, 2022
  Michael Solomon, Ph.D.
  II-3