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  <!-- Field: Rule-Page --><DIV STYLE="margin-top: 0in; margin-bottom: 0in; width: 100%"><DIV STYLE="font-size: 1pt; border-top: Black 2pt solid; border-bottom: Black 1pt solid">&nbsp;</DIV></DIV><!-- Field: /Rule-Page -->
  
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  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>UNITED STATES </B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>SECURITIES AND EXCHANGE COMMISSION</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>WASHINGTON, D.C. 20549</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>FORM S-8</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>REGISTRATION STATEMENT</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>UNDER THE SECURITIES ACT OF 1933</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B><U>OptimizeRx Corp.</U></B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">(Exact name of registrant as specified in
  its charter)</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>
  
  <TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%">
  <TR STYLE="vertical-align: top">
      <TD STYLE="border-bottom: Black 1.5pt solid; width: 49%; font-size: 10pt; text-align: center"><FONT STYLE="font-size: 10pt"><B>Nevada</B></FONT></TD>
      <TD STYLE="padding-bottom: 1.5pt; width: 2%">&nbsp;</TD>
      <TD STYLE="border-bottom: Black 1.5pt solid; width: 49%; font-size: 10pt; text-align: center"><FONT STYLE="font-size: 10pt"><B>26-1265381</B></FONT></TD></TR>
  <TR STYLE="vertical-align: top">
      <TD STYLE="text-align: center; font-size: 10pt"><FONT STYLE="font-size: 10pt">(State or other jurisdiction <BR>
  of incorporation or organization)</FONT></TD>
      <TD>&nbsp;</TD>
      <TD STYLE="text-align: center; font-size: 10pt"><FONT STYLE="font-size: 10pt">(I.R.S. Employer <BR>
  Identification No.)</FONT></TD></TR>
  </TABLE>
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>400 Water Street, Suite 200, </B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B><U>Rochester, MI 48307</U></B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">(Address of Principal Executive Offices)</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B><U>Amended and Restated OptimizeRx Corp.
  2013 Incentive Plan</U></B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">(Full title of the plan)</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>Spring Valley Solutions, LLC</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>4955 S. Durango Rd. Ste. 165</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B><U>Las Vegas, NV 89113</U></B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">(Name and address of agent for service)</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B><U>(702) 982-5686 </U></B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">(Telephone number, including area Code,
  of agent for service)</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Indicate by check mark whether the Registrant is a large accelerated
  filer, an accelerated filer, a non-accelerated filer, a smaller reporting company or an emerging growth company. See the definitions
  of &ldquo;large accelerated filer,&rdquo; &ldquo;accelerated filer,&rdquo; &ldquo;smaller reporting company&rdquo; and &ldquo;emerging
  growth company&rdquo; in Rule 12b-2 of the Exchange Act.</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
  
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      <TD STYLE="vertical-align: top; width: 6%; text-align: left">&nbsp;</TD>
      <TD STYLE="width: 23%; text-align: left"><FONT STYLE="font-size: 10pt">Large accelerated filer:</FONT></TD>
      <TD STYLE="width: 6%; text-align: center"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#9744;</FONT></TD>
      <TD STYLE="width: 17%; text-align: center">&nbsp;</TD>
      <TD STYLE="width: 30%; text-align: left"><FONT STYLE="font-size: 10pt">Accelerated filer:</FONT></TD>
      <TD STYLE="width: 12%; text-align: left"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#9744;</FONT></TD>
      <TD STYLE="width: 6%; text-align: center">&nbsp;</TD></TR>
  <TR>
      <TD STYLE="vertical-align: top; text-align: left">&nbsp;</TD>
      <TD STYLE="text-align: left"><FONT STYLE="font-size: 10pt">Non-accelerated filer:</FONT></TD>
      <TD STYLE="text-align: center"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#9746;</FONT></TD>
      <TD STYLE="text-align: center">&nbsp;</TD>
      <TD STYLE="text-align: left"><FONT STYLE="font-size: 10pt">Smaller reporting company:</FONT></TD>
      <TD STYLE="text-align: left"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#9746;</FONT></TD>
      <TD STYLE="text-align: center">&nbsp;</TD></TR>
  <TR>
      <TD STYLE="vertical-align: top; text-align: left">&nbsp;</TD>
      <TD STYLE="text-align: left">&nbsp;</TD>
      <TD STYLE="text-align: center">&nbsp;</TD>
      <TD STYLE="text-align: center">&nbsp;</TD>
      <TD STYLE="text-align: left"><FONT STYLE="font-size: 10pt">Emerging growth company:</FONT></TD>
      <TD STYLE="text-align: left"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#9744;</FONT></TD>
      <TD STYLE="text-align: center">&nbsp;</TD></TR>
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  <P STYLE="margin: 0">&nbsp;</P>
  
  <TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
  <TR>
      <TD STYLE="vertical-align: top; text-align: left; font-size: 10pt; width: 95%"><FONT STYLE="font-size: 10pt">If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 7(a)(2)(B) of the Securities Act.</FONT></TD>
      <TD STYLE="text-align: center; font-size: 10pt; width: 5%"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#9744;</FONT></TD></TR>
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  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"></P>
  
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  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><FONT STYLE="font-variant: small-caps"><B>&nbsp;</B></FONT></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><FONT STYLE="font-variant: small-caps"><B>Calculation
  of Registration Fee</B></FONT></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
  
  <TABLE CELLPADDING="0" CELLSPACING="0" STYLE="border-collapse: collapse; width: 100%; font: 10pt Times New Roman, Times, Serif">
  <TR STYLE="vertical-align: bottom">
      <TD STYLE="border-bottom: Black 1.5pt solid"><B>Title of each class of securities to be registered</B></TD><TD STYLE="padding-bottom: 1.5pt"><B>&nbsp;</B></TD>
      <TD COLSPAN="2" STYLE="text-align: center; border-bottom: Black 1.5pt solid"><FONT STYLE="font-size: 10pt"><B>Amount to be
      registered&nbsp;<SUP>(1)</SUP></B></FONT></TD><TD STYLE="padding-bottom: 1.5pt"><B>&nbsp;</B></TD><TD STYLE="padding-bottom: 1.5pt"><B>&nbsp;</B></TD>
      <TD COLSPAN="2" STYLE="text-align: center; border-bottom: Black 1.5pt solid"><FONT STYLE="font-size: 10pt"><B>Proposed maximum
      offering price per share&nbsp;<SUP>(2)</SUP></B></FONT></TD><TD STYLE="padding-bottom: 1.5pt"><B>&nbsp;</B></TD><TD STYLE="padding-bottom: 1.5pt"><B>&nbsp;</B></TD>
      <TD COLSPAN="2" STYLE="text-align: center; border-bottom: Black 1.5pt solid"><B>Proposed maximum aggregate offering price</B></TD><TD STYLE="padding-bottom: 1.5pt"><B>&nbsp;</B></TD><TD STYLE="padding-bottom: 1.5pt"><B>&nbsp;</B></TD>
      <TD COLSPAN="2" STYLE="text-align: center; border-bottom: Black 1.5pt solid"><B>Amount of registration fee</B></TD><TD STYLE="padding-bottom: 1.5pt"><B>&nbsp;</B></TD></TR>
  <TR STYLE="vertical-align: bottom; background-color: rgb(204,238,255)">
      <TD STYLE="width: 52%">Common&nbsp;&nbsp;Stock $0.001 par value</TD><TD STYLE="width: 1%">&nbsp;</TD>
      <TD STYLE="width: 1%; text-align: left">&nbsp;</TD><TD STYLE="width: 9%; text-align: right">3,000,000</TD><TD STYLE="width: 1%; text-align: left">&nbsp;</TD><TD STYLE="width: 1%">&nbsp;</TD>
      <TD STYLE="width: 1%; text-align: left">$</TD><TD STYLE="width: 9%; text-align: right">46.63</TD><TD STYLE="width: 1%; text-align: left">&nbsp;</TD><TD STYLE="width: 1%">&nbsp;</TD>
      <TD STYLE="width: 1%; text-align: left">$</TD><TD STYLE="width: 9%; text-align: right">139,890,000</TD><TD STYLE="width: 1%; text-align: left">&nbsp;</TD><TD STYLE="width: 1%">&nbsp;</TD>
      <TD STYLE="width: 1%; text-align: left">$</TD><TD STYLE="width: 9%; text-align: right">15,262.00</TD><TD STYLE="width: 1%; text-align: left">&nbsp;</TD></TR>
  </TABLE>
  
  
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
  
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  <TR STYLE="vertical-align: top">
      <TD STYLE="width: 24px"><FONT STYLE="font-size: 10pt"><SUP>(1)</SUP></FONT></TD>
      <TD>
          <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">This Registration Statement covers an additional 3,000,000 shares
          of Common Stock that may be offered or issued pursuant to the Amended and Restated OptimizeRx Corp. 2013 Equity Incentive Plan
          (the &ldquo;Plan&rdquo;). In addition, pursuant to Rule 416(c) under the Securities Act of 1933, as amended (the &ldquo;Securities
          Act&rdquo;), this Registration Statement also covers an indeterminate number of shares of Common Stock that may be offered or issued
          by reason of stock splits, stock dividends or similar transactions that become issuable under the Plan.</P>
          <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P></TD></TR>
  <TR STYLE="vertical-align: top">
      <TD><FONT STYLE="font-size: 10pt"><SUP>(2)</SUP></FONT></TD>
      <TD><FONT STYLE="font-size: 10pt">Estimated in accordance with Rule 457(c) promulgated under the Securities Act solely for the purpose of calculating the amount of the registration fee on the basis of the average of the high and low price per share of the Registrant&rsquo;s Common Stock as reported on the Nasdaq Capital Market on March 26, 2021.</FONT></TD></TR>
  </TABLE>
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">This registration statement shall become effective upon filing
  in accordance with Rule 462 under the Securities Act.</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"></P>
  
  <!-- Field: Rule-Page --><DIV STYLE="margin-top: 0in; margin-bottom: 0in; width: 100%"><DIV STYLE="font-size: 1pt; border-top: Black 1pt solid; border-bottom: Black 2pt solid">&nbsp;</DIV></DIV><!-- Field: /Rule-Page -->
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
  
  
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      <DIV STYLE="break-before: page; margin-top: 6pt; margin-bottom: 12pt"><P STYLE="margin: 0pt">&nbsp;</P></DIV>
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  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B>&nbsp;</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>EXPLANATORY NOTE</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">In accordance with General Instruction&nbsp;E
  to Form&nbsp;S-8, this Registration Statement incorporates by reference the contents of Registration Statement No. 333-237630 on
  Form S-8 filed by OptimizeRx Corp. (the &ldquo;Company&rdquo;) on April 10, 2020, the Registration Statement No. 333-230212 on
  Form S-8 filed by the Company on March 12, 2019, the Registration Statement No.&nbsp;333-210653 on Form S-8 filed by the Company
  on April 8, 2016 and the Registration Statement No. 333- 189439 on Form S-8 filed by the Company on June 19, 2013, relating to
  shares of Common Stock issuable pursuant to the OptimizeRx Corp. 2013 Incentive Plan (as amended and restated, the &ldquo;Plan&rdquo;).
  This Registration Statement, which is being filed to register an additional 3,000,000 shares of Common Stock made available for
  issuance pursuant to the Plan, consists of the facing page, this page, other required information, required opinions, consents
  and other exhibits, and the signature page.</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
  
  
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      <DIV STYLE="break-before: page; margin-top: 6pt; margin-bottom: 12pt"><P STYLE="margin: 0pt">&nbsp;</P></DIV>
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  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>PART II</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><FONT STYLE="font-variant: small-caps"><B>Information
  Required in the Registration Statement</B></FONT></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B>Item 3. Incorporation of Documents by Reference<FONT STYLE="font-variant: small-caps">.</FONT></B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">The SEC allows us to &ldquo;incorporate
  by reference&rdquo; the information we file with the SEC. This permits us to disclose important information to you by referring
  to these filed documents. Any information referred to in this way is considered part of this prospectus supplement. The information
  incorporated by reference is an important part of this prospectus supplement and the accompanying prospectus, and information that
  we file later with the SEC will automatically update and supersede this information. We incorporate by reference the following
  documents that have been filed with the SEC (other than information furnished under Item 2.02, Item 7.01 and Item 8.01 of Form 8-K
  and all exhibits related to such items):</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
  
  <TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
  <TD STYLE="width: 0.5in"></TD><TD STYLE="width: 0.25in">&#9679;</TD><TD>Our Annual Report on <A HREF="http://www.sec.gov/Archives/edgar/data/1448431/000121390021013996/f10k2020_optimizerx.htm">Form 10-K</A> for the fiscal year ended December 31, 2020, filed with the SEC on March 8, 2021;</TD></TR></TABLE>
  
  <TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
  <TD STYLE="width: 0.5in"></TD><TD STYLE="width: 0.25in">&#9679;</TD><TD>The description of our common stock in our Registration Statement on <A HREF="http://www.sec.gov/Archives/edgar/data/1448431/000121390021007404/ea134797-s3asr_optimizerx.htm">Form S-3ASR</A>, filed with the SEC on February 8, 2021, including
  any amendment, supplements or reports filed for the purpose of updating such description.</TD></TR></TABLE>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">In addition, all other documents filed (not
  furnished) by us pursuant to Section 13(a), Section 13(c), Section 14 or Section 15(d) of the Exchange Act on or after the date
  of this reoffer prospectus and prior to the termination of this offering, shall be deemed to be incorporated by reference into
  this reoffer prospectus and to be a part of this reoffer prospectus from the date of the filing of such documents; provided, however,
  that documents or information deemed to have been furnished to and not filed with the SEC in accordance with the rules of the SEC
  shall not be deemed incorporated by reference into this reoffer prospectus.</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">Any information in any of the foregoing
  documents will automatically be deemed to be modified or superseded to the extent that information in this prospectus supplement
  and the accompanying prospectus or in a later filed document that is incorporated or deemed to be incorporated herein by reference
  modifies or replaces such information.</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
  
  <P STYLE="text-align: left; font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">You may request, orally or in writing, a
  copy of these documents, which will be provided to you at no cost (other than exhibits, unless such exhibits are specifically incorporate
  by reference), by contacting Douglas Baker, c/o OptimizeRx Corporation, at 400 Water Street, Suite 200, Rochester, MI 48307. Our
  telephone number is (248) 651-6568.</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B>Item 8. Exhibits.</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B>&nbsp;</B></P>
  
  <TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
  <TR>
      <TD STYLE="vertical-align: top; width: 9%; border-bottom: black 1.5pt solid; padding-right: 3.2pt"><FONT STYLE="font-size: 10pt"><B>Exhibit Number</B></FONT></TD>
      <TD STYLE="width: 1%">&nbsp;</TD>
      <TD STYLE="vertical-align: bottom; width: 90%; border-bottom: black 1.5pt solid; padding-right: 0.8pt; text-align: left"><FONT STYLE="font-size: 10pt"><B>Description</B></FONT></TD></TR>
  <TR STYLE="background-color: rgb(204,238,255)">
      <TD STYLE="vertical-align: top; padding-right: 3.2pt"><FONT STYLE="font-size: 10pt">4.1</FONT></TD>
      <TD STYLE="vertical-align: bottom; padding-right: 0.8pt; text-align: left">&nbsp;</TD>
      <TD STYLE="vertical-align: bottom; padding-right: 0.8pt; text-align: left"><A HREF="http://www.sec.gov/Archives/edgar/data/1448431/000136110608000414/optimizerx_s1-ex0301.htm"><FONT STYLE="font-size: 10pt">Articles of Incorporation of OptimizeRx Corporation (the &ldquo;Company&rdquo;)<SUP>1</SUP></FONT></A></TD></TR>
  <TR STYLE="background-color: White">
      <TD STYLE="vertical-align: top; padding-right: 3.2pt"><FONT STYLE="font-size: 10pt">4.2</FONT></TD>
      <TD STYLE="vertical-align: bottom; padding-right: 0.8pt; text-align: left">&nbsp;</TD>
      <TD STYLE="vertical-align: bottom; padding-right: 0.8pt; text-align: left"><A HREF="http://www.sec.gov/Archives/edgar/data/1448431/000125529410000605/ex3_1.htm"><FONT STYLE="font-size: 10pt">Amended and Restated Bylaws of the Company<SUP>2</SUP></FONT></A></TD></TR>
  <TR STYLE="background-color: rgb(204,238,255)">
      <TD STYLE="vertical-align: top; padding-right: 3.2pt"><FONT STYLE="font-size: 10pt">4.3</FONT></TD>
      <TD STYLE="vertical-align: bottom; padding-right: 0.8pt; text-align: left">&nbsp;</TD>
      <TD STYLE="vertical-align: bottom; padding-right: 0.8pt; text-align: left"><A HREF="http://www.sec.gov/Archives/edgar/data/1448431/000121390019003962/f10k2018ex3-5_optimizerx.htm"><FONT STYLE="font-size: 10pt">Certificate of Correction of the Company, dated April 30, 2018<SUP>3</SUP></FONT></A></TD></TR>
  <TR STYLE="background-color: White">
      <TD STYLE="vertical-align: top; padding-right: 3.2pt"><FONT STYLE="font-size: 10pt">4.4**</FONT></TD>
      <TD STYLE="vertical-align: bottom; padding-right: 0.8pt; text-align: left">&nbsp;</TD>
      <TD STYLE="vertical-align: bottom; padding-right: 0.8pt; text-align: left"><A HREF="ea138494ex4-4_optimizerx.htm"><FONT STYLE="font-size: 10pt">Fifth Amended and Restated 2013 Equity Incentive Plan</FONT></A></TD></TR>
  <TR STYLE="background-color: rgb(204,238,255)">
      <TD STYLE="vertical-align: top; padding-right: 3.2pt"><FONT STYLE="font-size: 10pt">5.1**</FONT></TD>
      <TD STYLE="vertical-align: bottom; padding-right: 0.8pt; text-align: left">&nbsp;</TD>
      <TD STYLE="vertical-align: bottom; padding-right: 0.8pt; text-align: left"><A HREF="ea138494ex5-1_optimizerx.htm"><FONT STYLE="font-size: 10pt">The Doney Law Firm Opinion and consent to use</FONT></A></TD></TR>
  <TR STYLE="background-color: White">
      <TD STYLE="vertical-align: top; padding-right: 3.2pt"><FONT STYLE="font-size: 10pt">23.1**</FONT></TD>
      <TD STYLE="vertical-align: bottom; padding-right: 0.8pt; text-align: left">&nbsp;</TD>
      <TD STYLE="vertical-align: bottom; padding-right: 0.8pt; text-align: left"><A HREF="ea138494ex23-1_optimizerx.htm"><FONT STYLE="font-size: 10pt">Consent
  of UHY LLP</FONT></A></TD></TR>
  <TR STYLE="background-color: rgb(204,238,255)">
      <TD STYLE="vertical-align: top; padding-right: 3.2pt"><FONT STYLE="font-size: 10pt">23.2**</FONT></TD>
      <TD STYLE="vertical-align: bottom; padding-right: 0.8pt; text-align: left">&nbsp;</TD>
      <TD STYLE="vertical-align: bottom; padding-right: 0.8pt; text-align: left"><FONT STYLE="font-size: 10pt"><A HREF="ea138494ex23-2_optimizerx.htm">Consent of Marcum LLP</A></FONT></TD></TR>
  <TR STYLE="background-color: White">
      <TD STYLE="vertical-align: top; padding-right: 3.2pt"><FONT STYLE="font-size: 10pt">24.1**</FONT></TD>
      <TD STYLE="vertical-align: bottom; padding-right: 0.8pt; text-align: left">&nbsp;</TD>
      <TD STYLE="vertical-align: bottom; padding-right: 0.8pt; text-align: left"><A HREF="#SIG"><FONT STYLE="font-size: 10pt">Power of Attorney (included on the signature page of this registration statement).</FONT></A></TD></TR>
  </TABLE>
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: left; text-indent: 0.5in">&nbsp;</P>
  
  <TABLE CELLPADDING="0" CELLSPACING="0" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; width: 100%"><TR STYLE="vertical-align: top; text-align: left">
  <TD STYLE="width: 0in"></TD><TD STYLE="width: 0.25in; text-align: left"><SUP>1</SUP></TD><TD STYLE="text-align: left">Incorporated by reference to the Form S-1, filed by the
  Company with the Securities and Exchange Commission on November 12, 2008.</TD>
  </TR></TABLE>
  
  <TABLE CELLPADDING="0" CELLSPACING="0" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; width: 100%"><TR STYLE="vertical-align: top; text-align: left">
  <TD STYLE="width: 0in"></TD><TD STYLE="width: 0.25in; text-align: left"><SUP>2</SUP></TD><TD STYLE="text-align: left">Incorporated by reference to the Form 8-K, filed by the
  Company with the Securities and Exchange Commission on July 16, 2010.</TD>
  </TR></TABLE>
  
  <TABLE CELLPADDING="0" CELLSPACING="0" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 0; width: 100%"><TR STYLE="vertical-align: top; text-align: justify">
  <TD STYLE="width: 0"></TD><TD STYLE="width: 0.25in; text-align: left"><SUP>3</SUP></TD><TD STYLE="text-align: justify">Incorporated by reference to the Form 10-K, filed by the
  Company with the Securities and Exchange Commission on March 12, 2019,</TD>
  </TR></TABLE>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: left">&nbsp;</P>
  
  <TABLE CELLPADDING="0" CELLSPACING="0" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; width: 100%"><TR STYLE="vertical-align: top; text-align: left">
  <TD STYLE="width: 0in"></TD><TD STYLE="width: 0.25in; text-align: left">**</TD><TD STYLE="text-align: left">provided herewith</TD>
  </TR></TABLE>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B>&nbsp;</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"></P>
  
  <!-- Field: Page; Sequence: 4; Options: NewSection; Value: 1 -->
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  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B>Item 9. Undertakings</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">The undersigned registrant hereby undertakes:</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">(1) To file, during any period in which
  offers or sales are being made, a post-effective amendment to this registration statement to:</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">(i) include any Prospectus required by Section 10(a)(3) of the
  Securities Act of 1933, as amended;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">(ii) reflect in the Prospectus any facts or events arising after
  the effective date of the registration statement (or the most recent post-effective amendment thereof) which, individually or in
  the aggregate, represent a fundamental change in the information set forth in the registration statement. Notwithstanding the foregoing,
  any increase or decrease in volume of securities offered (if the total dollar value of securities offered would not exceed that
  which was registered) and any deviation from the low or high end of the estimated maximum offering range may be reflected in the
  form of Prospectus filed with the Securities and Exchange Commission pursuant to Rule 424(b) if, in the aggregate, the changes
  in volume and price represent no more than a 20% change in the maximum aggregate offering price set forth in the &ldquo;Calculation
  of Registration Fee&rdquo; table in the effective registration statement; and</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">(iii) include any material information with respect to the plan
  of distribution not previously disclosed in the registration statement or any material change to such information in the registration
  statement;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">(2) That, for the purpose of determining
  any liability under the Securities Act of 1933, as amended, each such post-effective amendment shall be deemed to be a new registration
  statement relating to the securities offered therein, and the offering of such securities at that time shall be deemed to be the
  initial bona fide offering thereof.</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">(3) To remove from registration by means
  of a post-effective amendment any of the securities being registered which remain unsold at the termination of the offering.</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">(4) For purposes of determining liability
  under the Securities Act of 1933 to any purchaser:</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">(i) If the Registrant is subject to Rule 430C, each Prospectus
  filed pursuant to Rule 424(b) as part of a registration statement relating to an offering, other than registration statements relying
  on Rule 430B or other than Prospectuses filed in reliance on Rule 430A, shall be deemed to be part of and included in the registration
  statement as of the date it is first used after effectiveness. Provided, however, that no statement made in a registration statement
  or Prospectus that is part of the registration or made in a document incorporated or deemed incorporated by reference into the
  registration statement or Prospectus that is part of the registration statement will, as to a purchaser with a time of contract
  of sale prior to such first use, supersede or modify any statement that was made in the registration statement or Prospectus that
  was part of the registration statement or made in any such document immediately prior to such date of first use.</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">(5) That for the purpose of determining
  liability of the registrant under the Securities Act of 1933 to any purchaser in the initial distribution of the securities:</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">The undersigned registrant undertakes that
  in a primary offering of securities of the undersigned registrant pursuant to this registration statement, regardless of the underwriting
  method used to sell the securities to the purchaser, if the securities are offered or sold to such purchaser by means of any of
  the following communications, the undersigned registrant will be a seller to the purchaser and will be considered to offer or sell
  such securities to such purchaser:</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">(i) Any preliminary Prospectus or Prospectus of the undersigned
  registrant relating to the offering required to be filed pursuant to Rule 424;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">(ii) Any free writing Prospectus relating to the offering prepared
  by or on behalf of the undersigned registrant or used or referred to by the undersigned registrant;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">(iii) The portion of any other free writing Prospectus relating
  to the offering containing material information about the undersigned registrant or its securities provided by or on behalf of
  the undersigned registrant; and</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">(iv) Any other communication that is an offer in the offering
  made by the undersigned registrant to the purchaser.</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">Insofar as indemnification for liabilities
  arising under the Securities Act of 1933 may be permitted to directors, officers and controlling persons of the registrant pursuant
  to the provisions described under Item 24 above, or otherwise, the registrant has been advised that in the opinion of the Securities
  and Exchange Commission such indemnification is against public policy as expressed in the Securities Act of 1933 and is, therefore,
  unenforceable. In the event that a claim for indemnification against such liabilities (other than the payment by the registrant
  of expenses incurred or paid by a director, officer or controlling person of the registrant in the successful defense of any action,
  suit or proceeding) is asserted by such director, officer or controlling person in connection with the securities being registered,
  the registrant will, unless in the opinion of its counsel the matter has been settled by controlling precedent, submit to a court
  of appropriate jurisdiction the question whether such indemnification by it is against public policy as expressed in the Securities
  Act of 1933 and will be governed by the final adjudication of such issue.</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&nbsp;</P>
  
  
  <!-- Field: Page; Sequence: 5; Value: 1 -->
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      <DIV STYLE="break-before: page; margin-top: 6pt; margin-bottom: 12pt"><P STYLE="margin: 0pt">&nbsp;</P></DIV>
      <!-- Field: /Page -->
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><A NAME="SIG"></A><B>SIGNATURES</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: left; text-indent: 0.5in">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: left; text-indent: 0.5in">In accordance with
  the requirements of the Securities Act of 1933, the registrant certifies that it has reasonable grounds to believe that it meets
  all of the requirements to a filing on Form S-8 and authorized this filing to be signed on its behalf by the undersigned, thereunto
  duly authorized, in the City of Rochester, Michigan on March 29, 2021.</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
  
  <TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%">
  <TR STYLE="vertical-align: top">
      <TD>&nbsp;</TD>
      <TD COLSPAN="2"><FONT STYLE="font-size: 10pt"><B>OPTIMIZERX CORPORATION</B></FONT></TD></TR>
  <TR STYLE="vertical-align: top">
      <TD STYLE="width: 60%">&nbsp;</TD>
      <TD STYLE="width: 4%">&nbsp;</TD>
      <TD STYLE="width: 36%">&nbsp;</TD></TR>
  <TR STYLE="vertical-align: top">
      <TD>&nbsp;</TD>
      <TD><FONT STYLE="font-size: 10pt">By:</FONT></TD>
      <TD STYLE="border-bottom: Black 1.5pt solid"><FONT STYLE="font-size: 10pt">/s/&nbsp;William Febbo</FONT></TD></TR>
  <TR>
      <TD STYLE="vertical-align: top">&nbsp;</TD>
      <TD STYLE="vertical-align: top">&nbsp;</TD>
      <TD STYLE="vertical-align: bottom"><FONT STYLE="font-size: 10pt">William Febbo</FONT></TD></TR>
  <TR STYLE="vertical-align: top">
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD><FONT STYLE="font-size: 10pt">Chief Executive Officer (Principal Executive Officer) and Director</FONT></TD></TR>
  <TR STYLE="vertical-align: top">
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD></TR>
  <TR STYLE="vertical-align: top">
      <TD>&nbsp;</TD>
      <TD><FONT STYLE="font-size: 10pt">By:</FONT></TD>
      <TD STYLE="border-bottom: Black 1.5pt solid"><FONT STYLE="font-size: 10pt">/s/&nbsp;Doug Baker</FONT></TD></TR>
  <TR STYLE="vertical-align: top">
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD><FONT STYLE="font-size: 10pt">Doug Baker</FONT></TD></TR>
  <TR STYLE="vertical-align: top">
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD><FONT STYLE="font-size: 10pt">Chief Financial Officer (Principal Financial and Accounting Officer) </FONT></TD></TR>
  </TABLE>
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; background-color: white">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; background-color: white"><B>POWER OF ATTORNEY</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; background-color: white">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: left; text-indent: 0.5in; background-color: white">KNOW
  ALL MEN BY THESE PRESENTS, that the undersigned officers and directors of the Company, hereby constitute and appoint William Febbo
  and Doug Baker and each of them, the true and lawful agents and attorneys-in-fact of the undersigned with full power and authority
  in said agents and attorneys-in-fact, and in any one or more of them, to sign for the undersigned and in their respective names
  as an officer/director of the Company, a registration statement on Form S-8 (or other appropriate form) relating to the offer and
  sale of common stock of the Company pursuant to the Plans (or any and all amendments, including post-effective amendments, to such
  registration statement) and file the same, with all exhibits thereto and other documents in connection therewith, with the Securities
  and Exchange Commission, and with full power of substitution; hereby ratifying and confirming all that each of said attorneys-in-fact,
  or his substitute or substitutes, may do or cause to be done by virtue hereof.</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: left; text-indent: 0.25in; background-color: white">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: left; text-indent: 0.5in; background-color: white">Pursuant
  to the requirements of the Securities Act of 1933, as amended, this Registration Statement has been signed by the following persons
  in the capacities and on the dates indicated.</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; background-color: white">&nbsp;</P>
  
  <TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
  <TR STYLE="vertical-align: top">
      <TD STYLE="border-bottom: Black 1.5pt solid; width: 24%"><FONT STYLE="font-size: 10pt">/s/ William Febbo</FONT></TD>
      <TD STYLE="width: 1%">&nbsp;</TD>
      <TD STYLE="width: 53%"><FONT STYLE="font-size: 10pt">Chief Executive Officer</FONT></TD>
      <TD STYLE="width: 1%">&nbsp;</TD>
      <TD STYLE="width: 21%"><FONT STYLE="font-size: 10pt">March 29, 2021</FONT></TD></TR>
  <TR STYLE="vertical-align: top">
      <TD><FONT STYLE="font-size: 10pt">William Febbo</FONT></TD>
      <TD>&nbsp;</TD>
      <TD><FONT STYLE="font-size: 10pt">(Principal Executive Officer) and Director</FONT></TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD></TR>
  <TR STYLE="vertical-align: top">
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD></TR>
  <TR STYLE="vertical-align: top">
      <TD STYLE="border-bottom: Black 1.5pt solid"><FONT STYLE="font-size: 10pt">/s/ Doug Baker</FONT></TD>
      <TD>&nbsp;</TD>
      <TD><FONT STYLE="font-size: 10pt">Chief Financial Officer</FONT></TD>
      <TD>&nbsp;</TD>
      <TD><FONT STYLE="font-size: 10pt">March 29, 2021</FONT></TD></TR>
  <TR STYLE="vertical-align: top">
      <TD><FONT STYLE="font-size: 10pt">Doug Baker</FONT></TD>
      <TD>&nbsp;</TD>
      <TD><FONT STYLE="font-size: 10pt">(Principal Financial and Accounting Officer)</FONT></TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD></TR>
  <TR STYLE="vertical-align: top">
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD></TR>
  <TR STYLE="vertical-align: top">
      <TD STYLE="border-bottom: Black 1.5pt solid"><FONT STYLE="font-size: 10pt">/s/ Lynn Vos</FONT></TD>
      <TD>&nbsp;</TD>
      <TD><FONT STYLE="font-size: 10pt">Director</FONT></TD>
      <TD>&nbsp;</TD>
      <TD><FONT STYLE="font-size: 10pt">March 29, 2021</FONT></TD></TR>
  <TR STYLE="vertical-align: top">
      <TD><FONT STYLE="font-size: 10pt">Lynn Vos</FONT></TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD></TR>
  <TR STYLE="vertical-align: top">
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD></TR>
  <TR STYLE="vertical-align: top">
      <TD STYLE="border-bottom: Black 1.5pt solid"><FONT STYLE="font-size: 10pt">/s/ Patrick Spangler</FONT></TD>
      <TD>&nbsp;</TD>
      <TD><FONT STYLE="font-size: 10pt">Director</FONT></TD>
      <TD>&nbsp;</TD>
      <TD><FONT STYLE="font-size: 10pt">March 29, 2021</FONT></TD></TR>
  <TR STYLE="vertical-align: top">
      <TD><FONT STYLE="font-size: 10pt">Patrick Spangler</FONT></TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD></TR>
  <TR STYLE="vertical-align: top">
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD></TR>
  <TR STYLE="vertical-align: top">
      <TD STYLE="border-bottom: Black 1.5pt solid"><FONT STYLE="font-size: 10pt">/s/ James Lang</FONT></TD>
      <TD>&nbsp;</TD>
      <TD><FONT STYLE="font-size: 10pt">Director</FONT></TD>
      <TD>&nbsp;</TD>
      <TD><FONT STYLE="font-size: 10pt">March 29, 2021</FONT></TD></TR>
  <TR STYLE="vertical-align: top">
      <TD><FONT STYLE="font-size: 10pt">James Lang</FONT></TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD></TR>
  <TR STYLE="vertical-align: top">
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD></TR>
  <TR STYLE="vertical-align: top">
      <TD STYLE="border-bottom: Black 1.5pt solid"><FONT STYLE="font-size: 10pt">/s/ Gus D. Halas</FONT></TD>
      <TD>&nbsp;</TD>
      <TD><FONT STYLE="font-size: 10pt">Director</FONT></TD>
      <TD>&nbsp;</TD>
      <TD><FONT STYLE="font-size: 10pt">March 29, 2021</FONT></TD></TR>
  <TR STYLE="vertical-align: top">
      <TD><FONT STYLE="font-size: 10pt">Gus D. Halas</FONT></TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD></TR>
  <TR STYLE="vertical-align: top">
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD></TR>
  <TR STYLE="vertical-align: top">
      <TD STYLE="border-bottom: Black 1.5pt solid"><FONT STYLE="font-size: 10pt">/s/ Greg Wasson</FONT></TD>
      <TD>&nbsp;</TD>
      <TD><FONT STYLE="font-size: 10pt">Director</FONT></TD>
      <TD>&nbsp;</TD>
      <TD><FONT STYLE="font-size: 10pt">March 29, 2021</FONT></TD></TR>
  <TR STYLE="vertical-align: top">
      <TD STYLE="border-top: Black 1pt solid"><FONT STYLE="font-size: 10pt">Greg Wasson</FONT></TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD></TR>
  </TABLE>
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; text-align: center; margin-top: 0pt; margin-bottom: 0pt">II-3</P>
  
  <!-- Field: Rule-Page --><DIV STYLE="margin-top: 0in; margin-bottom: 0in; width: 100%"><DIV STYLE="font-size: 1pt; border-top: Black 1.5pt solid">&nbsp;</DIV></DIV><!-- Field: /Rule-Page -->
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in"></P>
  
  </BODY>
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metadata_filer: {"company-data": {"conformed-name": "OptimizeRx Corp", "cik": "0001448431", "assigned-sic": "7389", "irs-number": "261265381", "state-of-incorporation": "NV", "fiscal-year-end": "1231"}, "filing-values": {"form-type": "S-8", "act": "33", "file-number": "333-254823", "film-number": "21781852"}, "business-address": {"street1": "400 WATER ST., STE. 200", "city": "ROCHESTER", "state": "MI", "zip": "48307", "phone": "248-651-6558"}, "mail-address": {"street1": "400 WATER ST., STE. 200", "city": "ROCHESTER", "state": "MI", "zip": "48307"}}
text: UNITED STATES
  SECURITIES AND EXCHANGE COMMISSION
  WASHINGTON, D.C. 20549
  FORM S-8
  REGISTRATION STATEMENT
  UNDER THE SECURITIES ACT OF 1933
  OptimizeRx Corp.
  (Exact name of registrant as specified in
  its charter)
  Nevada
  26-1265381
  (State or other jurisdiction
  of incorporation or organization)
  (I.R.S. Employer
  Identification No.)
  400 Water Street, Suite 200,
  Rochester, MI 48307
  (Address of Principal Executive Offices)
  Amended and Restated OptimizeRx Corp.
  2013 Incentive Plan
  (Full title of the plan)
  Spring Valley Solutions, LLC
  4955 S. Durango Rd. Ste. 165
  Las Vegas, NV 89113
  (Name and address of agent for service)
  (702) 982-5686
  (Telephone number, including area Code,
  of agent for service)
  Indicate by check mark whether the Registrant is a large accelerated
  filer, an accelerated filer, a non-accelerated filer, a smaller reporting company or an emerging growth company. See the definitions
  of "large accelerated filer," "accelerated filer," "smaller reporting company" and "emerging
  growth company" in Rule 12b-2 of the Exchange Act.
  Large accelerated filer:
  ☐
  Accelerated filer:
  ☐
  Non-accelerated filer:
  ☒
  Smaller reporting company:
  ☒
  Emerging growth company:
  ☐
  If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 7(a)(2)(B) of the Securities Act.
  ☐
  Calculation
  of Registration Fee
  Title of each class of securities to be registered
  Amount to be
      registered
  (1)
  Proposed maximum
      offering price per share
  (2)
  Proposed maximum aggregate offering price
  Amount of registration fee
  Common  Stock $0.001 par value
  3,000,000
  $
  46.63
  $
  139,890,000
  $
  15,262.00
  (1)
  This Registration Statement covers an additional 3,000,000 shares
          of Common Stock that may be offered or issued pursuant to the Amended and Restated OptimizeRx Corp. 2013 Equity Incentive Plan
          (the "Plan"). In addition, pursuant to Rule 416(c) under the Securities Act of 1933, as amended (the "Securities
          Act"), this Registration Statement also covers an indeterminate number of shares of Common Stock that may be offered or issued
          by reason of stock splits, stock dividends or similar transactions that become issuable under the Plan.
  (2)
  Estimated in accordance with Rule 457(c) promulgated under the Securities Act solely for the purpose of calculating the amount of the registration fee on the basis of the average of the high and low price per share of the Registrant's Common Stock as reported on the Nasdaq Capital Market on March 26, 2021.
  This registration statement shall become effective upon filing
  in accordance with Rule 462 under the Securities Act.
  EXPLANATORY NOTE
  In accordance with General Instruction E
  to Form S-8, this Registration Statement incorporates by reference the contents of Registration Statement No. 333-237630 on
  Form S-8 filed by OptimizeRx Corp. (the "Company") on April 10, 2020, the Registration Statement No. 333-230212 on
  Form S-8 filed by the Company on March 12, 2019, the Registration Statement No. 333-210653 on Form S-8 filed by the Company
  on April 8, 2016 and the Registration Statement No. 333- 189439 on Form S-8 filed by the Company on June 19, 2013, relating to
  shares of Common Stock issuable pursuant to the OptimizeRx Corp. 2013 Incentive Plan (as amended and restated, the "Plan").
  This Registration Statement, which is being filed to register an additional 3,000,000 shares of Common Stock made available for
  issuance pursuant to the Plan, consists of the facing page, this page, other required information, required opinions, consents
  and other exhibits, and the signature page.
  PART II
  Information
  Required in the Registration Statement
  Item 3. Incorporation of Documents by Reference
  .
  The SEC allows us to "incorporate
  by reference" the information we file with the SEC. This permits us to disclose important information to you by referring
  to these filed documents. Any information referred to in this way is considered part of this prospectus supplement. The information
  incorporated by reference is an important part of this prospectus supplement and the accompanying prospectus, and information that
  we file later with the SEC will automatically update and supersede this information. We incorporate by reference the following
  documents that have been filed with the SEC (other than information furnished under Item 2.02, Item 7.01 and Item 8.01 of Form 8-K
  and all exhibits related to such items):
  ●
  Our Annual Report on
  Form 10-K
  for the fiscal year ended December 31, 2020, filed with the SEC on March 8, 2021;
  ●
  The description of our common stock in our Registration Statement on
  Form S-3ASR
  , filed with the SEC on February 8, 2021, including
  any amendment, supplements or reports filed for the purpose of updating such description.
  In addition, all other documents filed (not
  furnished) by us pursuant to Section 13(a), Section 13(c), Section 14 or Section 15(d) of the Exchange Act on or after the date
  of this reoffer prospectus and prior to the termination of this offering, shall be deemed to be incorporated by reference into
  this reoffer prospectus and to be a part of this reoffer prospectus from the date of the filing of such documents; provided, however,
  that documents or information deemed to have been furnished to and not filed with the SEC in accordance with the rules of the SEC
  shall not be deemed incorporated by reference into this reoffer prospectus.
  Any information in any of the foregoing
  documents will automatically be deemed to be modified or superseded to the extent that information in this prospectus supplement
  and the accompanying prospectus or in a later filed document that is incorporated or deemed to be incorporated herein by reference
  modifies or replaces such information.
  You may request, orally or in writing, a
  copy of these documents, which will be provided to you at no cost (other than exhibits, unless such exhibits are specifically incorporate
  by reference), by contacting Douglas Baker, c/o OptimizeRx Corporation, at 400 Water Street, Suite 200, Rochester, MI 48307. Our
  telephone number is (248) 651-6568.
  Item 8. Exhibits.
  Exhibit Number
  Description
  4.1
  Articles of Incorporation of OptimizeRx Corporation (the "Company")
  1
  4.2
  Amended and Restated Bylaws of the Company
  2
  4.3
  Certificate of Correction of the Company, dated April 30, 2018
  3
  4.4**
  Fifth Amended and Restated 2013 Equity Incentive Plan
  5.1**
  The Doney Law Firm Opinion and consent to use
  23.1**
  Consent
  of UHY LLP
  23.2**
  Consent of Marcum LLP
  24.1**
  Power of Attorney (included on the signature page of this registration statement).
  1
  Incorporated by reference to the Form S-1, filed by the
  Company with the Securities and Exchange Commission on November 12, 2008.
  2
  Incorporated by reference to the Form 8-K, filed by the
  Company with the Securities and Exchange Commission on July 16, 2010.
  3
  Incorporated by reference to the Form 10-K, filed by the
  Company with the Securities and Exchange Commission on March 12, 2019,
  **
  provided herewith
  II-
  1
  Item 9. Undertakings
  The undersigned registrant hereby undertakes:
  (1) To file, during any period in which
  offers or sales are being made, a post-effective amendment to this registration statement to:
  (i) include any Prospectus required by Section 10(a)(3) of the
  Securities Act of 1933, as amended;
  (ii) reflect in the Prospectus any facts or events arising after
  the effective date of the registration statement (or the most recent post-effective amendment thereof) which, individually or in
  the aggregate, represent a fundamental change in the information set forth in the registration statement. Notwithstanding the foregoing,
  any increase or decrease in volume of securities offered (if the total dollar value of securities offered would not exceed that
  which was registered) and any deviation from the low or high end of the estimated maximum offering range may be reflected in the
  form of Prospectus filed with the Securities and Exchange Commission pursuant to Rule 424(b) if, in the aggregate, the changes
  in volume and price represent no more than a 20% change in the maximum aggregate offering price set forth in the "Calculation
  of Registration Fee" table in the effective registration statement; and
  (iii) include any material information with respect to the plan
  of distribution not previously disclosed in the registration statement or any material change to such information in the registration
  statement;
  (2) That, for the purpose of determining
  any liability under the Securities Act of 1933, as amended, each such post-effective amendment shall be deemed to be a new registration
  statement relating to the securities offered therein, and the offering of such securities at that time shall be deemed to be the
  initial bona fide offering thereof.
  (3) To remove from registration by means
  of a post-effective amendment any of the securities being registered which remain unsold at the termination of the offering.
  (4) For purposes of determining liability
  under the Securities Act of 1933 to any purchaser:
  (i) If the Registrant is subject to Rule 430C, each Prospectus
  filed pursuant to Rule 424(b) as part of a registration statement relating to an offering, other than registration statements relying
  on Rule 430B or other than Prospectuses filed in reliance on Rule 430A, shall be deemed to be part of and included in the registration
  statement as of the date it is first used after effectiveness. Provided, however, that no statement made in a registration statement
  or Prospectus that is part of the registration or made in a document incorporated or deemed incorporated by reference into the
  registration statement or Prospectus that is part of the registration statement will, as to a purchaser with a time of contract
  of sale prior to such first use, supersede or modify any statement that was made in the registration statement or Prospectus that
  was part of the registration statement or made in any such document immediately prior to such date of first use.
  (5) That for the purpose of determining
  liability of the registrant under the Securities Act of 1933 to any purchaser in the initial distribution of the securities:
  The undersigned registrant undertakes that
  in a primary offering of securities of the undersigned registrant pursuant to this registration statement, regardless of the underwriting
  method used to sell the securities to the purchaser, if the securities are offered or sold to such purchaser by means of any of
  the following communications, the undersigned registrant will be a seller to the purchaser and will be considered to offer or sell
  such securities to such purchaser:
  (i) Any preliminary Prospectus or Prospectus of the undersigned
  registrant relating to the offering required to be filed pursuant to Rule 424;
  (ii) Any free writing Prospectus relating to the offering prepared
  by or on behalf of the undersigned registrant or used or referred to by the undersigned registrant;
  (iii) The portion of any other free writing Prospectus relating
  to the offering containing material information about the undersigned registrant or its securities provided by or on behalf of
  the undersigned registrant; and
  (iv) Any other communication that is an offer in the offering
  made by the undersigned registrant to the purchaser.
  Insofar as indemnification for liabilities
  arising under the Securities Act of 1933 may be permitted to directors, officers and controlling persons of the registrant pursuant
  to the provisions described under Item 24 above, or otherwise, the registrant has been advised that in the opinion of the Securities
  and Exchange Commission such indemnification is against public policy as expressed in the Securities Act of 1933 and is, therefore,
  unenforceable. In the event that a claim for indemnification against such liabilities (other than the payment by the registrant
  of expenses incurred or paid by a director, officer or controlling person of the registrant in the successful defense of any action,
  suit or proceeding) is asserted by such director, officer or controlling person in connection with the securities being registered,
  the registrant will, unless in the opinion of its counsel the matter has been settled by controlling precedent, submit to a court
  of appropriate jurisdiction the question whether such indemnification by it is against public policy as expressed in the Securities
  Act of 1933 and will be governed by the final adjudication of such issue.
  II-
  2
  SIGNATURES
  In accordance with
  the requirements of the Securities Act of 1933, the registrant certifies that it has reasonable grounds to believe that it meets
  all of the requirements to a filing on Form S-8 and authorized this filing to be signed on its behalf by the undersigned, thereunto
  duly authorized, in the City of Rochester, Michigan on March 29, 2021.
  OPTIMIZERX CORPORATION
  By:
  /s/ William Febbo
  William Febbo
  Chief Executive Officer (Principal Executive Officer) and Director
  By:
  /s/ Doug Baker
  Doug Baker
  Chief Financial Officer (Principal Financial and Accounting Officer)
  POWER OF ATTORNEY
  KNOW
  ALL MEN BY THESE PRESENTS, that the undersigned officers and directors of the Company, hereby constitute and appoint William Febbo
  and Doug Baker and each of them, the true and lawful agents and attorneys-in-fact of the undersigned with full power and authority
  in said agents and attorneys-in-fact, and in any one or more of them, to sign for the undersigned and in their respective names
  as an officer/director of the Company, a registration statement on Form S-8 (or other appropriate form) relating to the offer and
  sale of common stock of the Company pursuant to the Plans (or any and all amendments, including post-effective amendments, to such
  registration statement) and file the same, with all exhibits thereto and other documents in connection therewith, with the Securities
  and Exchange Commission, and with full power of substitution; hereby ratifying and confirming all that each of said attorneys-in-fact,
  or his substitute or substitutes, may do or cause to be done by virtue hereof.
  Pursuant
  to the requirements of the Securities Act of 1933, as amended, this Registration Statement has been signed by the following persons
  in the capacities and on the dates indicated.
  /s/ William Febbo
  Chief Executive Officer
  March 29, 2021
  William Febbo
  (Principal Executive Officer) and Director
  /s/ Doug Baker
  Chief Financial Officer
  March 29, 2021
  Doug Baker
  (Principal Financial and Accounting Officer)
  /s/ Lynn Vos
  Director
  March 29, 2021
  Lynn Vos
  /s/ Patrick Spangler
  Director
  March 29, 2021
  Patrick Spangler
  /s/ James Lang
  Director
  March 29, 2021
  James Lang
  /s/ Gus D. Halas
  Director
  March 29, 2021
  Gus D. Halas
  /s/ Greg Wasson
  Director
  March 29, 2021
  Greg Wasson
  II-3