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  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>As filed with the Securities and Exchange Commission
  on August 16, 2021</B></P>
  
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  <P STYLE="text-align: right; font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B>Registration No. 333-&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</B></P>
  
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  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center"><B>UNITED STATES</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center"><B>SECURITIES AND EXCHANGE COMMISSION</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center"><B>WASHINGTON, D.C. 20549</B></P>
  
  <P STYLE="font: 7pt Times New Roman, Times, Serif; text-align: center; margin-top: 0pt; margin-bottom: 0pt">&nbsp;</P> <!-- Field: Rule-Page --><DIV STYLE="margin: 0pt auto; width: 25%"><DIV STYLE="font-size: 1pt; border-top: Black 1.5pt solid">&nbsp;</DIV></DIV><!-- Field: /Rule-Page -->
  
  
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  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center"><B>FORM&nbsp;S-8</B></P>
  
  <P STYLE="font: 7pt Times New Roman, Times, Serif; text-align: center; margin-top: 0pt; margin-bottom: 0pt">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center"><B>REGISTRATION STATEMENT</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center"><B>UNDER</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center"><B>THE SECURITIES ACT OF 1933</B></P> <!-- Field: Rule-Page --><DIV STYLE="font: 7pt Times New Roman, Times, Serif; margin: 0pt auto; width: 25%">&nbsp;</DIV>
  
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  <P STYLE="font: 7pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center"><B>&nbsp;</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center"><FONT STYLE="font-size: 12pt"><B>SENESTECH, INC.</B></FONT><B><FONT STYLE="font-size: 10pt"><BR>
  </FONT></B><FONT STYLE="font-size: 10pt">(Exact name of registrant as specified in its charter)</FONT></P>
  
  <P STYLE="font: 7pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center">&nbsp;</P>
  
  <TABLE CELLSPACING="0" CELLPADDING="0" STYLE="width: 100%; font: 10pt Times New Roman, Times, Serif; border-collapse: collapse">
    <TR STYLE="vertical-align: bottom">
      <TD STYLE="border-bottom: Black 1.5pt solid; width: 49%; padding-right: 3pt; padding-left: 3pt; font-size: 10pt; text-align: center"><FONT STYLE="font-size: 10pt"><B>Delaware</B></FONT></TD>
      <TD STYLE="padding-bottom: 1.5pt; width: 2%">&nbsp;</TD>
      <TD STYLE="border-bottom: Black 1.5pt solid; width: 49%; padding-right: 3pt; padding-left: 3pt; font-size: 10pt; text-align: center"><FONT STYLE="font-size: 10pt"><B>20-2079805</B></FONT></TD></TR>
    <TR STYLE="vertical-align: top">
      <TD STYLE="padding-right: 3pt; padding-left: 3pt; font-size: 10pt; text-align: center"><FONT STYLE="font-size: 10pt">(State or other jurisdiction of<BR>
  incorporation or organization)</FONT></TD>
      <TD>&nbsp;</TD>
      <TD STYLE="padding-right: 3pt; padding-left: 3pt; font-size: 10pt; text-align: center"><FONT STYLE="font-size: 10pt">(I.R.S. Employer<BR>
  Identification No.)</FONT></TD></TR>
    </TABLE>
  <P STYLE="font: 7pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center"><B>&nbsp;</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center"><B>23460 N. 19th Avenue, Suite 110<BR>
  Phoenix, AZ 85027<BR>
  (928) 779-4143<BR>
  </B>(Address of Principal Executive Offices, including zip code)</P>
  
  <P STYLE="font: 7pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center"><B>SENESTECH, INC. 2018 EQUITY INCENTIVE PLAN,
  AS AMENDED<BR>
  </B>(Full title of the plan)</P>
  
  <P STYLE="font: 7pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center"><B>Thomas C. Chesterman</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>Chief Financial Officer and Treasurer</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>SenesTech, Inc.</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>23460 N. 19th Avenue, Suite 110<BR>
  Phoenix, AZ 85027<BR>
  (928) 779-4143</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">(Name, address, including zip code and telephone
  number, including area code, of agent for service)</P>
  
  <P STYLE="font: 7pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P> <!-- Field: Rule-Page --><DIV STYLE="margin: 0pt auto; width: 25%"><DIV STYLE="font-size: 1pt; border-top: Black 1.5pt solid">&nbsp;</DIV></DIV><!-- Field: /Rule-Page -->
  
  
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  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>Copy to:</B>&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>Chris Hall<BR>
  Perkins Coie LLP<BR>
  1120 NW Couch Street, Tenth Floor</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>Portland, Oregon 97209-4128</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>(503) 727-2000</B></P>
  
  <P STYLE="font: 7pt Times New Roman, Times, Serif; text-align: center; margin-top: 0pt; margin-bottom: 0pt">&nbsp;</P> <!-- Field: Rule-Page --><DIV STYLE="margin: 0pt auto; width: 25%"><DIV STYLE="font-size: 1pt; border-top: Black 1.5pt solid">&nbsp;</DIV></DIV><!-- Field: /Rule-Page -->
  
  
  <P STYLE="margin: 0pt 0; font-size: 8pt"><FONT STYLE="font-size: 7pt">&nbsp;</FONT></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Indicate by check mark whether the registrant is a large accelerated
  filer, an accelerated filer, a non-accelerated filer, a smaller reporting company, or an emerging growth company. See the definitions
  of &ldquo;large accelerated filer,&rdquo; &ldquo;accelerated filer,&rdquo; &ldquo;smaller reporting company,&rdquo; and &ldquo;emerging
  growth company&rdquo; in Rule&nbsp;12b-2 of the Exchange Act.</P>
  
  <P STYLE="font: 7pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
  
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    <TR>
      <TD STYLE="white-space: nowrap; vertical-align: bottom; width: 21%"><FONT STYLE="font-size: 10pt">Large accelerated filer </FONT></TD>
      <TD STYLE="vertical-align: bottom; width: 9%"> &#9744;</TD>
      <TD STYLE="vertical-align: bottom; width: 2%; text-align: center">&nbsp;</TD>
      <TD STYLE="vertical-align: top; width: 37%; text-align: center"><FONT STYLE="font-size: 10pt">Non-accelerated filer&nbsp; &#9746;</FONT></TD>
      <TD STYLE="vertical-align: bottom; width: 2%; text-align: center">&nbsp;</TD>
      <TD STYLE="vertical-align: bottom; width: 29%; text-align: right"><FONT STYLE="font-size: 10pt">Smaller reporting company&nbsp;&#9746;</FONT></TD></TR>
    <TR>
      <TD STYLE="white-space: nowrap; vertical-align: top"><FONT STYLE="font-size: 10pt">Accelerated filer </FONT></TD>
      <TD STYLE="vertical-align: top">&#9744;</TD>
      <TD STYLE="vertical-align: bottom; text-align: center">&nbsp;</TD>
      <TD STYLE="vertical-align: top; text-align: center">&nbsp;</TD>
      <TD STYLE="vertical-align: top; text-align: center">&nbsp;</TD>
      <TD STYLE="vertical-align: top; text-align: right"><FONT STYLE="font-size: 10pt">Emerging growth company &#9746;</FONT></TD></TR>
    </TABLE>
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><FONT STYLE="font-size: 7pt">&nbsp;</FONT></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">If an emerging growth company, indicate by check mark if the registrant
  has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant
  to Section 7(a)(2)(B) of the Securities Act. &#9746;</P>
  
  <P STYLE="margin: 0pt 0; font-size: 8pt"><FONT STYLE="font-size: 7pt">&nbsp;</FONT></P>
  
  
  
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  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><FONT STYLE="font-size: 7pt">&nbsp;</FONT></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>CALCULATION OF REGISTRATION FEE</B></P>
  
  <P STYLE="margin: 0pt 0; font-size: 8pt"><FONT STYLE="font-size: 7pt">&nbsp;</FONT></P>
  
  <TABLE CELLPADDING="0" CELLSPACING="0" STYLE="border-collapse: collapse; width: 100%; font: 10pt Times New Roman, Times, Serif">
    <TR STYLE="vertical-align: bottom">
      <TD STYLE="border-bottom: Black 1.5pt solid; font-weight: bold; text-align: left">Title&nbsp;of&nbsp;Securities to&nbsp;Be&nbsp;Registered</TD><TD STYLE="font-weight: bold; padding-bottom: 1.5pt">&nbsp;</TD>
      <TD COLSPAN="2" STYLE="font-weight: bold; text-align: center; border-bottom: Black 1.5pt solid">Amount&nbsp;to&nbsp;Be<BR> Registered (1)</TD><TD STYLE="padding-bottom: 1.5pt; font-weight: bold">&nbsp;</TD><TD STYLE="font-weight: bold; padding-bottom: 1.5pt">&nbsp;</TD>
      <TD COLSPAN="2" STYLE="font-weight: bold; text-align: center; border-bottom: Black 1.5pt solid">Proposed&nbsp;Maximum<BR> Offering&nbsp;Price&nbsp;Per<BR> Share (2)</TD><TD STYLE="padding-bottom: 1.5pt; font-weight: bold">&nbsp;</TD><TD STYLE="font-weight: bold; padding-bottom: 1.5pt">&nbsp;</TD>
      <TD COLSPAN="2" STYLE="font-weight: bold; text-align: center; border-bottom: Black 1.5pt solid">Proposed&nbsp;Maximum<BR> Aggregate&nbsp;Offering<BR> Price (2)</TD><TD STYLE="padding-bottom: 1.5pt; font-weight: bold">&nbsp;</TD><TD STYLE="font-weight: bold; padding-bottom: 1.5pt">&nbsp;</TD>
      <TD COLSPAN="2" STYLE="font-weight: bold; text-align: center; border-bottom: Black 1.5pt solid">Amount&nbsp;of<BR> Registration&nbsp;Fee (2)</TD><TD STYLE="padding-bottom: 1.5pt; font-weight: bold">&nbsp;</TD></TR>
    <TR STYLE="vertical-align: bottom; background-color: rgb(204,238,255)">
      <TD STYLE="width: 52%; text-align: left; padding-bottom: 4pt; text-indent: -10pt; padding-left: 10pt">Common Stock, $0.001 par value, under the SenesTech, Inc. 2018 Equity Incentive Plan, as amended</TD><TD STYLE="width: 1%; border-bottom: Black 4pt double">&nbsp;</TD>
      <TD STYLE="width: 1%; border-bottom: Black 4pt double; text-align: left">&nbsp;</TD><TD STYLE="width: 9%; border-bottom: Black 4pt double; text-align: right">3,000,000</TD><TD STYLE="width: 1%; padding-bottom: 4pt; text-align: left">&nbsp;</TD><TD STYLE="width: 1%; border-bottom: Black 4pt double">&nbsp;</TD>
      <TD STYLE="width: 1%; border-bottom: Black 4pt double; text-align: left">$</TD><TD STYLE="width: 9%; border-bottom: Black 4pt double; text-align: right">1.565</TD><TD STYLE="width: 1%; padding-bottom: 4pt; text-align: left">&nbsp;</TD><TD STYLE="width: 1%; border-bottom: Black 4pt double">&nbsp;</TD>
      <TD STYLE="width: 1%; border-bottom: Black 4pt double; text-align: left">$</TD><TD STYLE="width: 9%; border-bottom: Black 4pt double; text-align: right">4,695,000</TD><TD STYLE="width: 1%; padding-bottom: 4pt; text-align: left">&nbsp;</TD><TD STYLE="width: 1%; border-bottom: Black 4pt double">&nbsp;</TD>
      <TD STYLE="width: 1%; border-bottom: Black 4pt double; text-align: left">$</TD><TD STYLE="width: 9%; border-bottom: Black 4pt double; text-align: right">512.22</TD><TD STYLE="width: 1%; padding-bottom: 4pt; text-align: left">&nbsp;</TD></TR>
    </TABLE>
  
  <P STYLE="font: 7pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 0">&nbsp;</P>
  
  <TABLE CELLPADDING="0" CELLSPACING="0" STYLE="width: 100%; font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
  <TD STYLE="width: 0%"></TD><TD STYLE="width: 0.25in">(1)</TD><TD>Pursuant to Rule 416(a) under the Securities Act, includes an indeterminate number of additional shares which may be necessary to
  adjust the number of shares issued pursuant to the plan as the result of any future stock split, stock dividend or similar adjustment
  of our outstanding common stock.</TD></TR></TABLE>
  
  <P STYLE="font: 7pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt">&nbsp;</P>
  
  <TABLE CELLPADDING="0" CELLSPACING="0" STYLE="width: 100%; font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
  <TD STYLE="width: 0%"></TD><TD STYLE="width: 0.25in">(2)</TD><TD>Estimated solely for the purpose of calculating the registration fee pursuant to Rule 457 under the Securities Act of 1933, as amended.
  The Proposed Maximum Offering Price Per Share is estimated to be $1.565 based on the average of the high sale price ($1.60) and the low
  sale price ($1.53) for our common stock as reported on the Nasdaq Capital Market on August 11, 2021.</TD></TR></TABLE>
  
  <P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif"><FONT STYLE="font-size: 7pt">&nbsp;</FONT></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"></P>
  
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  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"></P>
  
  
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      <DIV STYLE="break-before: page; margin-top: 6pt; margin-bottom: 12pt"><P STYLE="margin: 0pt">&nbsp;</P></DIV>
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  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B>&nbsp;</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>PART&nbsp;II</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>INFORMATION REQUIRED IN REGISTRATION STATEMENT</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B>Item 3. INCORPORATION
  OF CERTAIN DOCUMENTS BY REFERENCE</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 38.9pt">The following documents filed by SenesTech, Inc.
  (the &ldquo;<U>Registrant</U>&rdquo;) with the Securities and Exchange Commission (the &ldquo;<U>Commission</U>&rdquo;) are hereby incorporated
  by reference into this Registration Statement:</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&nbsp;</P>
  
  <TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
  <TD STYLE="width: 38.9pt"></TD><TD STYLE="width: 24.1pt">(a)</TD><TD>The Registrant&rsquo;s Annual Report on <A HREF="http://www.sec.gov/Archives/edgar/data/1680378/000121390021018287/f10k2020_senestechinc.htm">Form 10-K</A> for the year ended December 31, 2020, filed on March&nbsp;29, 2021;</TD></TR></TABLE>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 38.9pt">&nbsp;</P>
  
  <TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
  <TD STYLE="width: 38.9pt"></TD><TD STYLE="width: 24.1pt">(b)</TD><TD>The Registrant&rsquo;s Quarterly Reports on Form 10-Q for the quarter ended <A HREF="http://www.sec.gov/Archives/edgar/data/1680378/000121390021026400/f10q0321_senestechinc.htm">March 31, 2021</A>, filed on May 14, 2021, and for the quarter
  ended <A HREF="https://www.sec.gov/ix?doc=/Archives/edgar/data/1680378/000121390021042464/f10q0621_senestech.htm">June 30, 2021</A>, filed on August 13, 2021;</TD></TR></TABLE>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 38.9pt">&nbsp;</P>
  
  <TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
  <TD STYLE="width: 38.9pt"></TD><TD STYLE="width: 24.1pt">(c)</TD><TD>The Registrant&rsquo;s Current Reports on Form 8-K filed on <A HREF="http://www.sec.gov/Archives/edgar/data/1680378/000121390021006124/ea134239-8k_senestech.htm">February 2, 2021</A>, <A HREF="http://www.sec.gov/Archives/edgar/data/1680378/000121390021017223/ea138230-8k_senestechinc.htm">March 23, 2021</A>, <A HREF="http://www.sec.gov/Archives/edgar/data/1680378/000121390021032857/ea142830-8k_senestechinc.htm">June 17, 2021</A> and <A HREF="http://www.sec.gov/Archives/edgar/data/1680378/000121390021034200/ea143334-8k_senestech.htm">June&nbsp;25, 2021</A>
  (excluding any reports, or portions thereof, deemed to have been furnished under Item 2.02 or Item 7.01 and any exhibits included with
  such Items); and</TD></TR></TABLE>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 38.9pt">&nbsp;</P>
  
  <TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
  <TD STYLE="width: 38.9pt"></TD><TD STYLE="width: 24.1pt">(d)</TD><TD>The description of the Registrant&rsquo;s common stock contained
                                              in the Registration Statement on <A HREF="http://www.sec.gov/Archives/edgar/data/1680378/000114420416132137/v452318_8a12b.htm">Form 8-A</A> (File No. 001-37941) filed on November
                                              7, 2016 under the Securities Exchange Act of 1934, as amended (the &ldquo;<U>Exchange
                                              Act</U>&rdquo;), as updated by the description of the Registrant&rsquo;s registered securities
                                              contained in <A HREF="http://www.sec.gov/Archives/edgar/data/1680378/000121390020006565/f10k2019ex4-1_senestech.htm">Exhibit 4.1</A> to the Registrant&rsquo;s Annual Report on Form 10-K for the year
                                              ended December 31, 2019, filed on March 17, 2020, as amended by <A HREF="http://www.sec.gov/Archives/edgar/data/1680378/000121390020009645/f10k2019a1_senestech.htm">Form 10-K/A</A> filed on April
                                              21, 2020, including any amendment or report filed for the purpose of updating such description.</TD></TR></TABLE>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">All documents the Registrant files pursuant to
  Sections 13(a), 13(c), 14 and 15(d)&nbsp;of the Exchange Act after the date hereof (excluding any documents or portions of such documents
  that are furnished under Item 2.02 or Item 7.01 of a current report on Form 8-K and any exhibits included with such Items), and prior
  to the filing of a post-effective amendment which indicates that the securities offered hereby have been sold or which deregisters all
  securities covered hereby then remaining unsold, shall also be deemed to be incorporated by reference into this Registration Statement
  and to be a part hereof commencing on the respective dates on which such documents are filed.</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B>&nbsp;</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"> <B>Item 4.</B> <B>DESCRIPTION OF SECURITIES</B></P>
  
  
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B>&nbsp;</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">Not applicable.</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B>&nbsp;</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"> <B>Item 5.</B> <B>INTERESTS OF NAMED EXPERTS AND COUNSEL</B></P>
  
  
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B>&nbsp;</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">None.</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B>&nbsp;</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"> <B>Item 6.</B> <B>INDEMNIFICATION OF DIRECTORS AND OFFICERS</B></P>
  
  
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 40.5pt">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">The Registrant is incorporated under the laws of
  the State of Delaware. Section 145 of the Delaware General Corporation Law provides that a Delaware corporation may indemnify any persons
  who were, are, or are threatened to be made, parties to any threatened, pending or completed action, suit or proceeding, whether civil,
  criminal, administrative or investigative (other than an action by or in the right of such corporation), by reason of the fact that such
  person is or was an officer, director, employee or agent of such corporation, or is or was serving at the request of such corporation
  as an officer, director, employee or agent of another corporation, partnership, joint venture, trust or other enterprise. The indemnification
  may include expenses (including attorneys&rsquo; fees), judgments, fines and amounts paid in settlement actually and reasonably incurred
  by such person in connection with defending or settling such action, suit or proceeding, provided that such person acted in good faith
  and in a manner he or she reasonably believed to be in or not opposed to the corporation&rsquo;s best interests except that no indemnification
  is permitted without judicial approval if the officer or director is adjudged to be liable to the corporation. Where an officer or director
  is successful on the merits or otherwise in the defense of any action referred to above, the corporation must indemnify him or her against
  the expenses (including attorneys&rsquo; fees) actually and reasonably incurred.</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">The Registrant&rsquo;s amended and restated certificate
  of incorporation, as amended, and amended and restated bylaws provide for the indemnification of its directors and officers to the fullest
  extent permitted under the Delaware General Corporation Law.</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in"></P>
  
  <!-- Field: Page; Sequence: 3; Options: NewSection; Value: 1 -->
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      <DIV STYLE="break-before: page; margin-top: 6pt; margin-bottom: 12pt"><P STYLE="margin: 0pt">&nbsp;</P></DIV>
      <!-- Field: /Page -->
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">Section 102(b)(7) of the Delaware General Corporation
  Law permits a corporation to provide in its certificate of incorporation that a director of the corporation shall not be personally liable
  to the corporation or its stockholders for monetary damages for breach of fiduciary duties as a director, except for liability for any:</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: -0.05pt">&nbsp;</P>
  
  <TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
  <TD STYLE="width: 0.5in"></TD><TD STYLE="width: 0.25in">&#9679;</TD><TD STYLE="text-align: justify">Breach of the director&rsquo;s duty of loyalty to the corporation or its stockholders;</TD></TR></TABLE>
  
  <P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>
  
  <TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
  <TD STYLE="width: 0.5in"></TD><TD STYLE="width: 0.25in">&#9679;</TD><TD STYLE="text-align: justify">Act or omission not in good faith or that involves intentional misconduct or a knowing violation of law;</TD></TR></TABLE>
  
  <P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>
  
  <TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
  <TD STYLE="width: 0.5in"></TD><TD STYLE="width: 0.25in">&#9679;</TD><TD STYLE="text-align: justify">Unlawful payment of dividends or unlawful stock purchase or redemption; or</TD></TR></TABLE>
  
  <P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>
  
  <TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
  <TD STYLE="width: 0.5in"></TD><TD STYLE="width: 0.25in">&#9679;</TD><TD STYLE="text-align: justify">Transaction from which the director derives an improper personal benefit.</TD></TR></TABLE>
  
  <P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">The Registrant&rsquo;s amended and restated certificate
  of incorporation, as amended, includes such a provision. Expenses incurred by any officer or director in defending any such action, suit
  or proceeding in advance of its final disposition shall be paid by the Registrant upon delivery to it of an undertaking, by or on behalf
  of such director or officer, to repay all amounts so advanced if it shall ultimately be determined that such director or officer is not
  entitled to be indemnified by the Registrant.</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">Section 174 of the Delaware General Corporation
  Law provides, among other things, that a director who willfully or negligently approves an unlawful payment of dividends or an unlawful
  stock purchase or redemption, may be held jointly and severally liable for such actions. A director who was either absent when the unlawful
  actions were approved or dissented at the time may avoid liability by causing his or her dissent to such actions to be entered in the
  books containing minutes of the meetings of the board of directors at the time such action occurred or immediately after such absent director
  receives notice of the unlawful acts.</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">As permitted by the Delaware General Corporation
  Law, the Registrant has entered into indemnification agreements with each of its directors and executive officers that require the Registrant
  to indemnify such persons against any and all costs and expenses (including attorneys&rsquo;, witness or other professional fees) actually
  and reasonably incurred by such persons in connection with any action, suit or proceeding (including derivative actions), whether actual
  or threatened, to which any such person may be made a party by reason of the fact that such person is or was a director or officer or
  is or was acting or serving as an officer, director, employee or agent of the Registrant or any of its affiliated enterprises. Under these
  agreements, the Registrant is not required to provide indemnification for certain matters, including:</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&nbsp;</P>
  
  <TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
  <TD STYLE="width: 36pt"></TD><TD STYLE="width: 22.5pt">&#9679;</TD><TD STYLE="text-align: justify">Indemnification for expenses or losses with respect to proceedings initiated by the director or officer,
  including any proceedings against the Registrant or its directors, officers, employees or other indemnitees and not by way of defense,
  with certain exceptions;</TD></TR></TABLE>
  
  <P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>
  
  <TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
  <TD STYLE="width: 36pt"></TD><TD STYLE="width: 22.5pt">&#9679;</TD><TD STYLE="text-align: justify">Indemnification for any proceeding if a final decision by a court of competent jurisdiction determines
  that such indemnification is prohibited by applicable law;</TD></TR></TABLE>
  
  <P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>
  
  <TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
  <TD STYLE="width: 36pt"></TD><TD STYLE="width: 22.5pt">&#9679;</TD><TD STYLE="text-align: justify">Indemnification for the disgorgement of profits arising from the purchase or sale by the director or officer
  of securities of the Registrant in violation of Section 16(b) of the Exchange Act, or any similar successor statute; or</TD></TR></TABLE>
  
  <P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>
  
  <TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
  <TD STYLE="width: 36pt"></TD><TD STYLE="width: 22.5pt">&#9679;</TD><TD STYLE="text-align: justify">Indemnification for the director or officer&rsquo;s reimbursement to the Registrant of any bonus or other
  incentive-based or equity-based compensation previously received by the director or officer or payment of any profits realized by the
  director or officer from the sale of securities of the Registrant, as required in each case under the Exchange Act.</TD></TR></TABLE>
  
  <P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">The indemnification agreements also set forth certain
  procedures that will apply in the event of a claim for indemnification thereunder. The Registrant has an insurance policy in place, with
  limits of $15.0 million in the aggregate, that covers its officers and directors with respect to certain liabilities, including liabilities
  arising under the Securities Act of 1933, as amended (the &ldquo;<U>Securities Act</U>&rdquo;) or otherwise. Insofar as indemnification
  for liabilities arising under the Securities Act may be permitted to directors, officers and controlling persons of the Registrant pursuant
  to the foregoing provisions, or otherwise, the Registrant has been advised that in the opinion of the Commission such indemnification
  is against public policy as expressed in the Securities Act and is, therefore, unenforceable.</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"> <B>Item 7.</B> <B>EXEMPTIONS FROM REGISTRATION CLAIMED</B></P>
  
  
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">Not applicable.</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"></P>
  
  
  
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"></P>
  
  <!-- Field: Page; Sequence: 4; Value: 1 -->
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      <DIV STYLE="break-before: page; margin-top: 6pt; margin-bottom: 12pt"><P STYLE="margin: 0pt">&nbsp;</P></DIV>
      <!-- Field: /Page -->
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B>&nbsp;</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B>Item 8. EXHIBITS</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B>&nbsp;</B></P>
  
  <TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
    <TR STYLE="vertical-align: bottom">
      <TD STYLE="border-bottom: Black 1.5pt solid; padding-right: 0.7pt; padding-left: 0.7pt; text-align: center"><FONT STYLE="font-size: 10pt"><B>Exhibit Number</B></FONT></TD>
      <TD STYLE="padding-bottom: 1.5pt; padding-right: 0.7pt; padding-left: 0.7pt; text-align: center">&nbsp;</TD>
      <TD STYLE="border-bottom: Black 1.5pt solid; padding-right: 0.7pt; padding-left: 0.7pt; text-align: center"><FONT STYLE="font-size: 10pt"><B>Description</B></FONT></TD></TR>
    <TR>
      <TD STYLE="vertical-align: top; width: 15%; padding-right: 0.7pt; padding-left: 0.7pt; text-align: center">&nbsp;</TD>
      <TD STYLE="vertical-align: bottom; width: 2%; padding-right: 0.7pt; padding-left: 0.7pt">&nbsp;</TD>
      <TD STYLE="vertical-align: top; width: 83%; padding-right: 0.7pt; padding-left: 0.7pt">&nbsp;</TD></TR>
    <TR STYLE="background-color: rgb(204,238,255)">
      <TD STYLE="vertical-align: top; padding-right: 0.7pt; padding-left: 0.7pt; text-align: center"><FONT STYLE="font-size: 10pt">5.1+</FONT></TD>
      <TD STYLE="vertical-align: bottom; padding-right: 0.7pt; padding-left: 0.7pt">&nbsp;</TD>
      <TD STYLE="vertical-align: top; padding-right: 0.7pt; padding-left: 0.7pt"><A HREF="ea145820ex5-1_senestech.htm"><FONT STYLE="font-size: 10pt">Opinion of Perkins Coie LLP regarding legality of the common stock being registered</FONT></A></TD></TR>
    <TR STYLE="background-color: White">
      <TD STYLE="vertical-align: top; padding-right: 0.7pt; padding-left: 0.7pt; text-align: center">&nbsp;</TD>
      <TD STYLE="vertical-align: bottom; padding-right: 0.7pt; padding-left: 0.7pt">&nbsp;</TD>
      <TD STYLE="vertical-align: top; padding-right: 0.7pt; padding-left: 0.7pt">&nbsp;</TD></TR>
    <TR STYLE="background-color: rgb(204,238,255)">
      <TD STYLE="vertical-align: top; padding-right: 0.7pt; padding-left: 0.7pt; text-align: center"><FONT STYLE="font-size: 10pt">23.1+</FONT></TD>
      <TD STYLE="vertical-align: bottom; padding-right: 0.7pt; padding-left: 0.7pt">&nbsp;</TD>
      <TD STYLE="vertical-align: top; padding-right: 0.7pt; padding-left: 0.7pt"><A HREF="ea145820ex23-1_senestech.htm"><FONT STYLE="font-size: 10pt">Consent of M&amp;K CPAS, PLLC</FONT></A></TD></TR>
    <TR STYLE="background-color: White">
      <TD STYLE="vertical-align: top; padding-right: 0.7pt; padding-left: 0.7pt; text-align: center">&nbsp;</TD>
      <TD STYLE="vertical-align: bottom; padding-right: 0.7pt; padding-left: 0.7pt">&nbsp;</TD>
      <TD STYLE="vertical-align: top; padding-right: 0.7pt; padding-left: 0.7pt">&nbsp;</TD></TR>
    <TR STYLE="background-color: rgb(204,238,255)">
      <TD STYLE="vertical-align: top; padding-right: 0.7pt; padding-left: 0.7pt; text-align: center"><FONT STYLE="font-size: 10pt">23.2+</FONT></TD>
      <TD STYLE="vertical-align: bottom; padding-right: 0.7pt; padding-left: 0.7pt">&nbsp;</TD>
      <TD STYLE="vertical-align: top; padding-right: 0.7pt; padding-left: 0.7pt"><A HREF="ea145820ex5-1_senestech.htm"><FONT STYLE="font-size: 10pt">Consent of Perkins Coie LLP (included in opinion filed as Exhibit&nbsp;5.1)</FONT></A></TD></TR>
    <TR STYLE="background-color: White">
      <TD STYLE="vertical-align: top; padding-right: 0.7pt; padding-left: 0.7pt; text-align: center">&nbsp;</TD>
      <TD STYLE="vertical-align: bottom; padding-right: 0.7pt; padding-left: 0.7pt">&nbsp;</TD>
      <TD STYLE="vertical-align: top; padding-right: 0.7pt; padding-left: 0.7pt">&nbsp;</TD></TR>
    <TR STYLE="background-color: rgb(204,238,255)">
      <TD STYLE="vertical-align: top; padding-right: 0.7pt; padding-left: 0.7pt; text-align: center"><FONT STYLE="font-size: 10pt">24.1+</FONT></TD>
      <TD STYLE="vertical-align: bottom; padding-right: 0.7pt; padding-left: 0.7pt">&nbsp;</TD>
      <TD STYLE="vertical-align: top; padding-right: 0.7pt; padding-left: 0.7pt"><A HREF="#a_014"><FONT STYLE="font-size: 10pt">Power of Attorney (see signature page)</FONT></A></TD></TR>
    <TR STYLE="background-color: White">
      <TD STYLE="vertical-align: top; padding-right: 0.7pt; padding-left: 0.7pt; text-align: center">&nbsp;</TD>
      <TD STYLE="vertical-align: bottom; padding-right: 0.7pt; padding-left: 0.7pt">&nbsp;</TD>
      <TD STYLE="vertical-align: top; padding-right: 0.7pt; padding-left: 0.7pt">&nbsp;</TD></TR>
    <TR STYLE="background-color: rgb(204,238,255)">
      <TD STYLE="vertical-align: top; padding-right: 0.7pt; padding-left: 0.7pt; text-align: center"><FONT STYLE="font-size: 10pt">99.1*</FONT></TD>
      <TD STYLE="vertical-align: bottom; padding-right: 0.7pt; padding-left: 0.7pt">&nbsp;</TD>
      <TD STYLE="vertical-align: top; padding-right: 0.7pt; padding-left: 0.7pt">
      <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><A HREF="https://www.sec.gov/Archives/edgar/data/1680378/000121390021042464/f10q0621ex10-1_senestech.htm" STYLE="-sec-extract: exhibit">SenesTech, Inc. 2018 Equity Incentive Plan, as amended (incorporated by reference to Exhibit 10.1 to the Registrant&rsquo;s Quarterly Report on Form 10-Q filed with the Commission on August 13, 2021)</A></P>
      <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B><I></I></B></P></TD></TR>
    </TABLE>
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
  
  <TABLE CELLPADDING="0" CELLSPACING="0" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; width: 100%"><TR STYLE="vertical-align: top; text-align: justify">
  <TD STYLE="width: 0%"></TD><TD STYLE="width: 0.25in; text-align: left">+</TD><TD STYLE="text-align: justify">Filed herewith.</TD>
  </TR></TABLE>
  
  <TABLE CELLPADDING="0" CELLSPACING="0" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; width: 100%"><TR STYLE="vertical-align: top; text-align: justify">
  <TD STYLE="width: 0%"></TD><TD STYLE="width: 0.25in; text-align: left">*</TD><TD STYLE="text-align: justify">Incorporated herein by reference.</TD>
  </TR></TABLE>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"> <B>Item 9.</B> <B>UNDERTAKINGS</B></P>
  
  
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">A. The
  undersigned Registrant hereby undertakes:</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">(1) To
  file, during any period in which offers or sales are being made, a post-effective amendment to this Registration Statement:</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.75in">(a) To
  include any prospectus required by Section&nbsp;10(a)(3)&nbsp;of the Securities Act;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.75in">(b) To
  reflect in the prospectus any facts or events arising after the effective date of this Registration Statement (or the most recent post-effective
  amendment thereof) which, individually or in the aggregate, represent a fundamental change in the information set forth in this Registration
  Statement; and</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: -0.75in; text-align: center">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.75in">(c)&nbsp; To
  include any material information with respect to the plan of distribution not previously disclosed in this Registration Statement or any
  material change to such information in this Registration Statement;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 1in">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><U>provided</U>,&nbsp;<U>however</U>, that paragraphs (1)(a)&nbsp;and
  (1)(b)&nbsp;above do not apply if the information required to be included in a post-effective amendment by those paragraphs is contained
  in reports filed with or furnished to the Commission by the Registrant pursuant to Section&nbsp;13 or&nbsp;15(d)&nbsp;of the Exchange
  Act that are incorporated by reference in this Registration Statement.</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">(2) That,
  for the purpose of determining any liability under the Securities Act, each such post-effective amendment shall be deemed to be a new
  registration statement relating to the securities offered therein, and the offering of such securities at that time shall be deemed to
  be the initial bona fide offering thereof.</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">(3) To
  remove from registration by means of a post-effective amendment any of the securities being registered which remain unsold at the termination
  of the offering.</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">B.&nbsp;&nbsp;The
  undersigned Registrant hereby undertakes that, for purposes of determining any liability under the Securities Act, each filing of the
  Registrant&rsquo;s annual report pursuant to Section&nbsp;13(a)&nbsp;or Section 15(d)&nbsp;of the Exchange Act (and, where applicable,
  each filing of an employee benefits plan&rsquo;s annual report pursuant to Section&nbsp;15(d)&nbsp;of the Exchange Act) that is incorporated
  by reference in this Registration Statement shall be deemed to be a new registration statement relating to the securities offered therein,
  and the offering of such securities at that time shall be deemed to be the initial bona fide offering thereof.</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">C.&nbsp;&nbsp;Insofar
  as indemnification for liabilities arising under the Securities Act may be permitted to directors, officers and controlling persons of
  the Registrant pursuant to the foregoing provisions, or otherwise, the Registrant has been advised that, in the opinion of the Commission,
  such indemnification is against public policy as expressed in the Securities Act and is, therefore, unenforceable. In the event that a
  claim for indemnification against such liabilities (other than the payment by the Registrant of expenses incurred or paid by a director,
  officer or controlling person of the Registrant in the successful defense of any action, suit or proceeding) is asserted by such director,
  officer or controlling person in connection with the securities being registered, the Registrant will, unless in the opinion of its counsel
  the matter has been settled by controlling precedent, submit to a court of appropriate jurisdiction the question whether such indemnification
  by it is against public policy as expressed in the Securities Act and will be governed by the final adjudication of such issue.</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"></P>
  
  
  
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"></P>
  
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  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B>&nbsp;</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B><A NAME="a_014"></A>SIGNATURES</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">Pursuant to the requirements of the Securities
  Act of 1933, the Registrant certifies that it has reasonable grounds to believe that it meets all the requirements for filing on Form&nbsp;S-8
  and has duly caused this Registration Statement to be signed on its behalf by the undersigned, thereunto duly authorized, in the City
  of Phoenix, State of Arizona, on August 16, 2021.</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&nbsp;</P>
  
  <TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
    <TR STYLE="vertical-align: top">
      <TD>&nbsp;</TD>
      <TD COLSPAN="2"><FONT STYLE="font-size: 10pt"><B>SENESTECH, INC. </B></FONT></TD></TR>
    <TR STYLE="vertical-align: top">
      <TD STYLE="width: 60%">&nbsp;</TD>
      <TD STYLE="width: 4%">&nbsp;</TD>
      <TD STYLE="width: 36%">&nbsp;</TD></TR>
    <TR STYLE="vertical-align: top">
      <TD><FONT STYLE="font-size: 10pt">&nbsp;</FONT></TD>
      <TD><FONT STYLE="font-size: 10pt">By:</FONT></TD>
      <TD STYLE="border-bottom: Black 1.5pt solid"><FONT STYLE="font-size: 10pt">/s/ Kenneth Siegel</FONT></TD></TR>
    <TR STYLE="vertical-align: top">
      <TD>&nbsp;</TD>
      <TD><FONT STYLE="font-size: 10pt"></FONT></TD>
      <TD><FONT STYLE="font-size: 10pt">Kenneth Siegel</FONT></TD></TR>
    <TR STYLE="vertical-align: top">
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD><FONT STYLE="font-size: 10pt">Chief Executive Officer</FONT></TD></TR>
    </TABLE>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&nbsp;</P>
  
  <P STYLE="text-align: center; font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><B>POWER OF ATTORNEY</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">Each person whose signature appears below authorizes
  Kenneth Siegel and Thomas C. Chesterman, or either of them, as attorneys-in-fact with full power of substitution, to execute in the name
  and on the behalf of each person, individually and in each capacity stated below, and to file, any and all amendments to this Registration
  Statement, including any and all post-effective amendments.</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">Pursuant to the requirements of the Securities
  Act of 1933, this Registration Statement has been signed by the following persons in the capacities indicated below on August 16, 2021.</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>
  
  <TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
    <TR>
      <TD STYLE="border-bottom: Black 1.5pt solid; vertical-align: top; width: 49%; padding-right: 0.7pt; padding-left: 0.7pt; text-align: center"><FONT STYLE="font-size: 10pt"><B>Signature</B></FONT></TD>
      <TD STYLE="padding-bottom: 1.5pt; vertical-align: bottom; width: 2%; padding-right: 0.7pt; padding-left: 0.7pt; text-align: center">&nbsp;</TD>
      <TD STYLE="border-bottom: Black 1.5pt solid; vertical-align: top; width: 49%; padding-right: 0.7pt; padding-left: 0.7pt; text-align: center"><FONT STYLE="font-size: 10pt"><B>Title</B></FONT></TD></TR>
    <TR>
      <TD STYLE="vertical-align: top; padding-right: 0.7pt; padding-left: 0.7pt">&nbsp;</TD>
      <TD STYLE="vertical-align: bottom; padding-right: 0.7pt; padding-left: 0.7pt">&nbsp;</TD>
      <TD STYLE="vertical-align: top; padding-right: 0.7pt; padding-left: 0.7pt; text-align: center">&nbsp;</TD></TR>
    <TR>
      <TD STYLE="border-bottom: Black 1.5pt solid; vertical-align: top; padding-right: 0.7pt; padding-left: 0.7pt; text-align: center"><FONT STYLE="font-size: 10pt">/s/ Kenneth Siegel</FONT></TD>
      <TD STYLE="vertical-align: bottom; padding-right: 0.7pt; padding-left: 0.7pt">&nbsp;</TD>
      <TD STYLE="vertical-align: top; padding-right: 0.7pt; padding-left: 0.7pt; text-align: center"><FONT STYLE="font-size: 10pt">Chief Executive Officer and Director</FONT></TD></TR>
    <TR>
      <TD STYLE="vertical-align: top; padding-right: 0.7pt; padding-left: 0.7pt; text-align: center"><FONT STYLE="font-size: 10pt">Kenneth Siegel</FONT></TD>
      <TD STYLE="vertical-align: bottom; padding-right: 0.7pt; padding-left: 0.7pt">&nbsp;</TD>
      <TD STYLE="vertical-align: top; padding-right: 0.7pt; padding-left: 20pt; text-align: center; text-indent: -10pt"><FONT STYLE="font-size: 10pt">(Principal Executive Officer)</FONT></TD></TR>
    <TR>
      <TD STYLE="vertical-align: top; padding-right: 0.7pt; padding-left: 0.7pt; text-align: center">&nbsp;</TD>
      <TD STYLE="vertical-align: bottom; padding-right: 0.7pt; padding-left: 0.7pt">&nbsp;</TD>
      <TD STYLE="vertical-align: top; padding-right: 0.7pt; padding-left: 20pt; text-align: center; text-indent: -10pt">&nbsp;</TD></TR>
    <TR>
      <TD STYLE="border-bottom: Black 1.5pt solid; vertical-align: top; padding-right: 0.7pt; padding-left: 0.7pt; text-align: center"><FONT STYLE="font-size: 10pt">/s/ Thomas C. Chesterman</FONT></TD>
      <TD STYLE="vertical-align: bottom; padding-right: 0.7pt; padding-left: 0.7pt">&nbsp;</TD>
      <TD STYLE="vertical-align: top; padding-right: 0.7pt; padding-left: 0.7pt; text-align: center"><FONT STYLE="font-size: 10pt">Chief Financial Officer and Treasurer </FONT></TD></TR>
    <TR>
      <TD STYLE="vertical-align: top; padding-right: 0.7pt; padding-left: 0.7pt; text-align: center"><FONT STYLE="font-size: 10pt">Thomas C. Chesterman</FONT></TD>
      <TD STYLE="vertical-align: bottom; padding-right: 0.7pt; padding-left: 0.7pt">&nbsp;</TD>
      <TD STYLE="vertical-align: top; padding-right: 0.7pt; padding-left: 20pt; text-align: center; text-indent: -10pt"><FONT STYLE="font-size: 10pt">(Principal Financial and Accounting Officer)</FONT></TD></TR>
    <TR>
      <TD STYLE="vertical-align: top; padding-right: 0.7pt; padding-left: 0.7pt; text-align: center">&nbsp;</TD>
      <TD STYLE="vertical-align: bottom; padding-right: 0.7pt; padding-left: 0.7pt">&nbsp;</TD>
      <TD STYLE="vertical-align: top; padding-right: 0.7pt; padding-left: 0.7pt; text-align: center">&nbsp;</TD></TR>
    <TR>
      <TD STYLE="border-bottom: Black 1.5pt solid; vertical-align: top; padding-right: 0.7pt; padding-left: 0.7pt; text-align: center"><FONT STYLE="font-size: 10pt">/s/ Jamie Bechtel</FONT></TD>
      <TD STYLE="vertical-align: bottom; padding-right: 0.7pt; padding-left: 0.7pt">&nbsp;</TD>
      <TD STYLE="vertical-align: top; padding-right: 0.7pt; padding-left: 0.7pt; text-align: center"><FONT STYLE="font-size: 10pt">Chair of the Board</FONT></TD></TR>
    <TR>
      <TD STYLE="vertical-align: top; padding-right: 0.7pt; padding-left: 0.7pt; text-align: center"><FONT STYLE="font-size: 10pt">Jamie Bechtel</FONT></TD>
      <TD STYLE="vertical-align: bottom; padding-right: 0.7pt; padding-left: 0.7pt">&nbsp;</TD>
      <TD STYLE="vertical-align: top; padding-right: 0.7pt; padding-left: 0.7pt; text-align: center">&nbsp;</TD></TR>
    <TR>
      <TD STYLE="vertical-align: top; padding-right: 0.7pt; padding-left: 0.7pt; text-align: center">&nbsp;</TD>
      <TD STYLE="vertical-align: bottom; padding-right: 0.7pt; padding-left: 0.7pt">&nbsp;</TD>
      <TD STYLE="vertical-align: top; padding-right: 0.7pt; padding-left: 0.7pt; text-align: center">&nbsp;</TD></TR>
    <TR>
      <TD STYLE="border-bottom: Black 1.5pt solid; vertical-align: top; padding-right: 0.7pt; padding-left: 0.7pt; text-align: center"><FONT STYLE="font-size: 10pt">/s/ Delphine Fran&ccedil;ois Chiavarini</FONT></TD>
      <TD STYLE="vertical-align: bottom; padding-right: 0.7pt; padding-left: 0.7pt">&nbsp;</TD>
      <TD STYLE="vertical-align: top; padding-right: 0.7pt; padding-left: 0.7pt; text-align: center"><FONT STYLE="font-size: 10pt">Director</FONT></TD></TR>
    <TR>
      <TD STYLE="vertical-align: top; padding-right: 0.7pt; padding-left: 0.7pt; text-align: center"><FONT STYLE="font-size: 10pt">Delphine Fran&ccedil;ois Chiavarini </FONT></TD>
      <TD STYLE="vertical-align: bottom; padding-right: 0.7pt; padding-left: 0.7pt">&nbsp;</TD>
      <TD STYLE="vertical-align: top; padding-right: 0.7pt; padding-left: 0.7pt; text-align: center">&nbsp;</TD></TR>
    <TR>
      <TD STYLE="vertical-align: top; padding-right: 0.7pt; padding-left: 0.7pt; text-align: center">&nbsp;</TD>
      <TD STYLE="vertical-align: bottom; padding-right: 0.7pt; padding-left: 0.7pt">&nbsp;</TD>
      <TD STYLE="vertical-align: top; padding-right: 0.7pt; padding-left: 0.7pt; text-align: center">&nbsp;</TD></TR>
    <TR>
      <TD STYLE="border-bottom: Black 1.5pt solid; vertical-align: top; padding-right: 0.7pt; padding-left: 0.7pt; text-align: center"><FONT STYLE="font-size: 10pt">/s/ Marc Dumont</FONT></TD>
      <TD STYLE="vertical-align: bottom; padding-right: 0.7pt; padding-left: 0.7pt">&nbsp;</TD>
      <TD STYLE="vertical-align: top; padding-right: 0.7pt; padding-left: 0.7pt; text-align: center"><FONT STYLE="font-size: 10pt">Director</FONT></TD></TR>
    <TR>
      <TD STYLE="vertical-align: top; padding-right: 0.7pt; padding-left: 0.7pt; text-align: center"><FONT STYLE="font-size: 10pt">Marc Dumont</FONT></TD>
      <TD STYLE="vertical-align: bottom; padding-right: 0.7pt; padding-left: 0.7pt">&nbsp;</TD>
      <TD STYLE="vertical-align: top; padding-right: 0.7pt; padding-left: 0.7pt; text-align: center">&nbsp;</TD></TR>
    <TR>
      <TD STYLE="vertical-align: top; padding-right: 0.7pt; padding-left: 0.7pt; text-align: center">&nbsp;</TD>
      <TD STYLE="vertical-align: bottom; padding-right: 0.7pt; padding-left: 0.7pt">&nbsp;</TD>
      <TD STYLE="vertical-align: top; padding-right: 0.7pt; padding-left: 0.7pt; text-align: center">&nbsp;</TD></TR>
    <TR>
      <TD STYLE="border-bottom: Black 1.5pt solid; vertical-align: top; padding-right: 0.7pt; padding-left: 0.7pt; text-align: center"><FONT STYLE="font-size: 10pt">/s/ Phil Grandinetti III</FONT></TD>
      <TD STYLE="vertical-align: bottom; padding-right: 0.7pt; padding-left: 0.7pt">&nbsp;</TD>
      <TD ROWSPAN="2" STYLE="vertical-align: top; padding-right: 0.7pt; padding-left: 0.7pt; text-align: center"><FONT STYLE="font-size: 10pt">Director</FONT></TD></TR>
    <TR>
      <TD STYLE="vertical-align: top; padding-right: 0.7pt; padding-left: 0.7pt; text-align: center"><FONT STYLE="font-size: 10pt">Phil Grandinetti III</FONT></TD>
      <TD STYLE="vertical-align: bottom; padding-right: 0.7pt; padding-left: 0.7pt">&nbsp;</TD></TR>
    <TR>
      <TD STYLE="vertical-align: top; padding-right: 0.7pt; padding-left: 0.7pt; text-align: center">&nbsp;</TD>
      <TD STYLE="vertical-align: bottom; padding-right: 0.7pt; padding-left: 0.7pt">&nbsp;</TD>
      <TD STYLE="vertical-align: top; padding-right: 0.7pt; padding-left: 0.7pt; text-align: center">&nbsp;</TD></TR>
    <TR>
      <TD STYLE="border-bottom: Black 1.5pt solid; vertical-align: top; padding-right: 0.7pt; padding-left: 0.7pt; text-align: center"><FONT STYLE="font-size: 10pt">/s/ K.C. Kavanagh</FONT></TD>
      <TD STYLE="vertical-align: bottom; padding-right: 0.7pt; padding-left: 0.7pt">&nbsp;</TD>
      <TD STYLE="vertical-align: top; padding-right: 0.7pt; padding-left: 0.7pt; text-align: center"><FONT STYLE="font-size: 10pt">Director</FONT></TD></TR>
    <TR>
      <TD STYLE="vertical-align: top; padding-right: 0.7pt; padding-left: 0.7pt; text-align: center"><FONT STYLE="font-size: 10pt">K.C. Kavanagh</FONT></TD>
      <TD STYLE="vertical-align: bottom; padding-right: 0.7pt; padding-left: 0.7pt">&nbsp;</TD>
      <TD STYLE="vertical-align: top; padding-right: 0.7pt; padding-left: 0.7pt; text-align: center">&nbsp;</TD></TR>
    <TR>
      <TD STYLE="vertical-align: top; padding-right: 0.7pt; padding-left: 0.7pt; text-align: center">&nbsp;</TD>
      <TD STYLE="vertical-align: bottom; padding-right: 0.7pt; padding-left: 0.7pt">&nbsp;</TD>
      <TD STYLE="vertical-align: top; padding-right: 0.7pt; padding-left: 0.7pt; text-align: center">&nbsp;</TD></TR>
    <TR>
      <TD STYLE="border-bottom: Black 1.5pt solid; vertical-align: top; padding-right: 0.7pt; padding-left: 0.7pt; text-align: center"><FONT STYLE="font-size: 10pt">/s/ Jake Leach</FONT></TD>
      <TD STYLE="vertical-align: bottom; padding-right: 0.7pt; padding-left: 0.7pt">&nbsp;</TD>
      <TD ROWSPAN="2" STYLE="vertical-align: top; padding-right: 0.7pt; padding-left: 0.7pt; text-align: center"><FONT STYLE="font-size: 10pt">Director</FONT></TD></TR>
    <TR>
      <TD STYLE="vertical-align: top; padding-right: 0.7pt; padding-left: 0.7pt; text-align: center"><FONT STYLE="font-size: 10pt">Jake Leach</FONT></TD>
      <TD STYLE="vertical-align: bottom; padding-right: 0.7pt; padding-left: 0.7pt">&nbsp;</TD></TR>
    <TR>
      <TD STYLE="vertical-align: top; padding-right: 0.7pt; padding-left: 0.7pt; text-align: center">&nbsp;</TD>
      <TD STYLE="vertical-align: bottom; padding-right: 0.7pt; padding-left: 0.7pt">&nbsp;</TD>
      <TD STYLE="vertical-align: top; padding-right: 0.7pt; padding-left: 0.7pt; text-align: center">&nbsp;</TD></TR>
    <TR>
      <TD STYLE="border-bottom: Black 1.5pt solid; vertical-align: top; padding-right: 0.7pt; padding-left: 0.7pt; text-align: center"><FONT STYLE="font-size: 10pt">/s/ Matthew K. Szot</FONT></TD>
      <TD STYLE="vertical-align: bottom; padding-right: 0.7pt; padding-left: 0.7pt">&nbsp;</TD>
      <TD STYLE="vertical-align: top; padding-right: 0.7pt; padding-left: 0.7pt; text-align: center"><FONT STYLE="font-size: 10pt">Director</FONT></TD></TR>
    <TR>
      <TD STYLE="vertical-align: top; padding-right: 0.7pt; padding-left: 0.7pt; text-align: center"><FONT STYLE="font-size: 10pt">Matthew K. Szot</FONT></TD>
      <TD STYLE="vertical-align: bottom; padding-right: 0.7pt; padding-left: 0.7pt">&nbsp;</TD>
      <TD STYLE="vertical-align: top; padding-right: 0.7pt; padding-left: 0.7pt; text-align: center">&nbsp;</TD></TR>
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metadata_documents: [{"type": "S-8", "sequence": "1", "filename": "ea145820-s8_senestech.htm", "description": "REGISTRATION STATEMENT", "secsgml_size_bytes": 62961}]
metadata_filer: {"company-data": {"conformed-name": "SenesTech, Inc.", "cik": "0001680378", "assigned-sic": "2870", "irs-number": "202079805", "state-of-incorporation": "DE", "fiscal-year-end": "1231"}, "filing-values": {"form-type": "S-8", "act": "33", "file-number": "333-258851", "film-number": "211177785"}, "business-address": {"street1": "3140 N. CADEN COURT", "street2": "SUITE 1", "city": "FLAGSTAFF", "state": "AZ", "zip": "86004", "phone": "(928) 779 - 4143"}, "mail-address": {"street1": "3140 N. CADEN COURT", "street2": "SUITE 1", "city": "FLAGSTAFF", "state": "AZ", "zip": "86004"}}
text: As filed with the Securities and Exchange Commission
  on August 16, 2021
  Registration No. 333-
  UNITED STATES
  SECURITIES AND EXCHANGE COMMISSION
  WASHINGTON, D.C. 20549
  FORM S-8
  REGISTRATION STATEMENT
  UNDER
  THE SECURITIES ACT OF 1933
  SENESTECH, INC.
  (Exact name of registrant as specified in its charter)
  Delaware
  20-2079805
  (State or other jurisdiction of
  incorporation or organization)
  (I.R.S. Employer
  Identification No.)
  23460 N. 19th Avenue, Suite 110
  Phoenix, AZ 85027
  (928) 779-4143
  (Address of Principal Executive Offices, including zip code)
  SENESTECH, INC. 2018 EQUITY INCENTIVE PLAN,
  AS AMENDED
  (Full title of the plan)
  Thomas C. Chesterman
  Chief Financial Officer and Treasurer
  SenesTech, Inc.
  23460 N. 19th Avenue, Suite 110
  Phoenix, AZ 85027
  (928) 779-4143
  (Name, address, including zip code and telephone
  number, including area code, of agent for service)
  Copy to:
  Chris Hall
  Perkins Coie LLP
  1120 NW Couch Street, Tenth Floor
  Portland, Oregon 97209-4128
  (503) 727-2000
  Indicate by check mark whether the registrant is a large accelerated
  filer, an accelerated filer, a non-accelerated filer, a smaller reporting company, or an emerging growth company. See the definitions
  of "large accelerated filer," "accelerated filer," "smaller reporting company," and "emerging
  growth company" in Rule 12b-2 of the Exchange Act.
  Large accelerated filer
  ☐
  Non-accelerated filer  ☒
  Smaller reporting company ☒
  Accelerated filer
  ☐
  Emerging growth company ☒
  If an emerging growth company, indicate by check mark if the registrant
  has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant
  to Section 7(a)(2)(B) of the Securities Act. ☒
  CALCULATION OF REGISTRATION FEE
  Title of Securities to Be Registered
  Amount to Be
  Registered (1)
  Proposed Maximum
  Offering Price Per
  Share (2)
  Proposed Maximum
  Aggregate Offering
  Price (2)
  Amount of
  Registration Fee (2)
  Common Stock, $0.001 par value, under the SenesTech, Inc. 2018 Equity Incentive Plan, as amended
  3,000,000
  $
  1.565
  $
  4,695,000
  $
  512.22
  (1)
  Pursuant to Rule 416(a) under the Securities Act, includes an indeterminate number of additional shares which may be necessary to
  adjust the number of shares issued pursuant to the plan as the result of any future stock split, stock dividend or similar adjustment
  of our outstanding common stock.
  (2)
  Estimated solely for the purpose of calculating the registration fee pursuant to Rule 457 under the Securities Act of 1933, as amended.
  The Proposed Maximum Offering Price Per Share is estimated to be $1.565 based on the average of the high sale price ($1.60) and the low
  sale price ($1.53) for our common stock as reported on the Nasdaq Capital Market on August 11, 2021.
  PART II
  INFORMATION REQUIRED IN REGISTRATION STATEMENT
  Item 3. INCORPORATION
  OF CERTAIN DOCUMENTS BY REFERENCE
  The following documents filed by SenesTech, Inc.
  (the "
  Registrant
  ") with the Securities and Exchange Commission (the "
  Commission
  ") are hereby incorporated
  by reference into this Registration Statement:
  (a)
  The Registrant's Annual Report on
  Form 10-K
  for the year ended December 31, 2020, filed on March 29, 2021;
  (b)
  The Registrant's Quarterly Reports on Form 10-Q for the quarter ended
  March 31, 2021
  , filed on May 14, 2021, and for the quarter
  ended
  June 30, 2021
  , filed on August 13, 2021;
  (c)
  The Registrant's Current Reports on Form 8-K filed on
  February 2, 2021
  ,
  March 23, 2021
  ,
  June 17, 2021
  and
  June 25, 2021
  (excluding any reports, or portions thereof, deemed to have been furnished under Item 2.02 or Item 7.01 and any exhibits included with
  such Items); and
  (d)
  The description of the Registrant's common stock contained
                                              in the Registration Statement on
  Form 8-A
  (File No. 001-37941) filed on November
                                              7, 2016 under the Securities Exchange Act of 1934, as amended (the "
  Exchange
                                              Act
  "), as updated by the description of the Registrant's registered securities
                                              contained in
  Exhibit 4.1
  to the Registrant's Annual Report on Form 10-K for the year
                                              ended December 31, 2019, filed on March 17, 2020, as amended by
  Form 10-K/A
  filed on April
                                              21, 2020, including any amendment or report filed for the purpose of updating such description.
  All documents the Registrant files pursuant to
  Sections 13(a), 13(c), 14 and 15(d) of the Exchange Act after the date hereof (excluding any documents or portions of such documents
  that are furnished under Item 2.02 or Item 7.01 of a current report on Form 8-K and any exhibits included with such Items), and prior
  to the filing of a post-effective amendment which indicates that the securities offered hereby have been sold or which deregisters all
  securities covered hereby then remaining unsold, shall also be deemed to be incorporated by reference into this Registration Statement
  and to be a part hereof commencing on the respective dates on which such documents are filed.
  Item 4.
  DESCRIPTION OF SECURITIES
  Not applicable.
  Item 5.
  INTERESTS OF NAMED EXPERTS AND COUNSEL
  None.
  Item 6.
  INDEMNIFICATION OF DIRECTORS AND OFFICERS
  The Registrant is incorporated under the laws of
  the State of Delaware. Section 145 of the Delaware General Corporation Law provides that a Delaware corporation may indemnify any persons
  who were, are, or are threatened to be made, parties to any threatened, pending or completed action, suit or proceeding, whether civil,
  criminal, administrative or investigative (other than an action by or in the right of such corporation), by reason of the fact that such
  person is or was an officer, director, employee or agent of such corporation, or is or was serving at the request of such corporation
  as an officer, director, employee or agent of another corporation, partnership, joint venture, trust or other enterprise. The indemnification
  may include expenses (including attorneys' fees), judgments, fines and amounts paid in settlement actually and reasonably incurred
  by such person in connection with defending or settling such action, suit or proceeding, provided that such person acted in good faith
  and in a manner he or she reasonably believed to be in or not opposed to the corporation's best interests except that no indemnification
  is permitted without judicial approval if the officer or director is adjudged to be liable to the corporation. Where an officer or director
  is successful on the merits or otherwise in the defense of any action referred to above, the corporation must indemnify him or her against
  the expenses (including attorneys' fees) actually and reasonably incurred.
  The Registrant's amended and restated certificate
  of incorporation, as amended, and amended and restated bylaws provide for the indemnification of its directors and officers to the fullest
  extent permitted under the Delaware General Corporation Law.
  II-
  1
  Section 102(b)(7) of the Delaware General Corporation
  Law permits a corporation to provide in its certificate of incorporation that a director of the corporation shall not be personally liable
  to the corporation or its stockholders for monetary damages for breach of fiduciary duties as a director, except for liability for any:
  ●
  Breach of the director's duty of loyalty to the corporation or its stockholders;
  ●
  Act or omission not in good faith or that involves intentional misconduct or a knowing violation of law;
  ●
  Unlawful payment of dividends or unlawful stock purchase or redemption; or
  ●
  Transaction from which the director derives an improper personal benefit.
  The Registrant's amended and restated certificate
  of incorporation, as amended, includes such a provision. Expenses incurred by any officer or director in defending any such action, suit
  or proceeding in advance of its final disposition shall be paid by the Registrant upon delivery to it of an undertaking, by or on behalf
  of such director or officer, to repay all amounts so advanced if it shall ultimately be determined that such director or officer is not
  entitled to be indemnified by the Registrant.
  Section 174 of the Delaware General Corporation
  Law provides, among other things, that a director who willfully or negligently approves an unlawful payment of dividends or an unlawful
  stock purchase or redemption, may be held jointly and severally liable for such actions. A director who was either absent when the unlawful
  actions were approved or dissented at the time may avoid liability by causing his or her dissent to such actions to be entered in the
  books containing minutes of the meetings of the board of directors at the time such action occurred or immediately after such absent director
  receives notice of the unlawful acts.
  As permitted by the Delaware General Corporation
  Law, the Registrant has entered into indemnification agreements with each of its directors and executive officers that require the Registrant
  to indemnify such persons against any and all costs and expenses (including attorneys', witness or other professional fees) actually
  and reasonably incurred by such persons in connection with any action, suit or proceeding (including derivative actions), whether actual
  or threatened, to which any such person may be made a party by reason of the fact that such person is or was a director or officer or
  is or was acting or serving as an officer, director, employee or agent of the Registrant or any of its affiliated enterprises. Under these
  agreements, the Registrant is not required to provide indemnification for certain matters, including:
  ●
  Indemnification for expenses or losses with respect to proceedings initiated by the director or officer,
  including any proceedings against the Registrant or its directors, officers, employees or other indemnitees and not by way of defense,
  with certain exceptions;
  ●
  Indemnification for any proceeding if a final decision by a court of competent jurisdiction determines
  that such indemnification is prohibited by applicable law;
  ●
  Indemnification for the disgorgement of profits arising from the purchase or sale by the director or officer
  of securities of the Registrant in violation of Section 16(b) of the Exchange Act, or any similar successor statute; or
  ●
  Indemnification for the director or officer's reimbursement to the Registrant of any bonus or other
  incentive-based or equity-based compensation previously received by the director or officer or payment of any profits realized by the
  director or officer from the sale of securities of the Registrant, as required in each case under the Exchange Act.
  The indemnification agreements also set forth certain
  procedures that will apply in the event of a claim for indemnification thereunder. The Registrant has an insurance policy in place, with
  limits of $15.0 million in the aggregate, that covers its officers and directors with respect to certain liabilities, including liabilities
  arising under the Securities Act of 1933, as amended (the "
  Securities Act
  ") or otherwise. Insofar as indemnification
  for liabilities arising under the Securities Act may be permitted to directors, officers and controlling persons of the Registrant pursuant
  to the foregoing provisions, or otherwise, the Registrant has been advised that in the opinion of the Commission such indemnification
  is against public policy as expressed in the Securities Act and is, therefore, unenforceable.
  Item 7.
  EXEMPTIONS FROM REGISTRATION CLAIMED
  Not applicable.
  II-
  2
  Item 8. EXHIBITS
  Exhibit Number
  Description
  5.1+
  Opinion of Perkins Coie LLP regarding legality of the common stock being registered
  23.1+
  Consent of M&K CPAS, PLLC
  23.2+
  Consent of Perkins Coie LLP (included in opinion filed as Exhibit 5.1)
  24.1+
  Power of Attorney (see signature page)
  99.1*
  SenesTech, Inc. 2018 Equity Incentive Plan, as amended (incorporated by reference to Exhibit 10.1 to the Registrant's Quarterly Report on Form 10-Q filed with the Commission on August 13, 2021)
  +
  Filed herewith.
  *
  Incorporated herein by reference.
  Item 9.
  UNDERTAKINGS
  A. The
  undersigned Registrant hereby undertakes:
  (1) To
  file, during any period in which offers or sales are being made, a post-effective amendment to this Registration Statement:
  (a) To
  include any prospectus required by Section 10(a)(3) of the Securities Act;
  (b) To
  reflect in the prospectus any facts or events arising after the effective date of this Registration Statement (or the most recent post-effective
  amendment thereof) which, individually or in the aggregate, represent a fundamental change in the information set forth in this Registration
  Statement; and
  (c)  To
  include any material information with respect to the plan of distribution not previously disclosed in this Registration Statement or any
  material change to such information in this Registration Statement;
  provided
  ,
  however
  , that paragraphs (1)(a) and
  (1)(b) above do not apply if the information required to be included in a post-effective amendment by those paragraphs is contained
  in reports filed with or furnished to the Commission by the Registrant pursuant to Section 13 or 15(d) of the Exchange
  Act that are incorporated by reference in this Registration Statement.
  (2) That,
  for the purpose of determining any liability under the Securities Act, each such post-effective amendment shall be deemed to be a new
  registration statement relating to the securities offered therein, and the offering of such securities at that time shall be deemed to
  be the initial bona fide offering thereof.
  (3) To
  remove from registration by means of a post-effective amendment any of the securities being registered which remain unsold at the termination
  of the offering.
  B.  The
  undersigned Registrant hereby undertakes that, for purposes of determining any liability under the Securities Act, each filing of the
  Registrant's annual report pursuant to Section 13(a) or Section 15(d) of the Exchange Act (and, where applicable,
  each filing of an employee benefits plan's annual report pursuant to Section 15(d) of the Exchange Act) that is incorporated
  by reference in this Registration Statement shall be deemed to be a new registration statement relating to the securities offered therein,
  and the offering of such securities at that time shall be deemed to be the initial bona fide offering thereof.
  C.  Insofar
  as indemnification for liabilities arising under the Securities Act may be permitted to directors, officers and controlling persons of
  the Registrant pursuant to the foregoing provisions, or otherwise, the Registrant has been advised that, in the opinion of the Commission,
  such indemnification is against public policy as expressed in the Securities Act and is, therefore, unenforceable. In the event that a
  claim for indemnification against such liabilities (other than the payment by the Registrant of expenses incurred or paid by a director,
  officer or controlling person of the Registrant in the successful defense of any action, suit or proceeding) is asserted by such director,
  officer or controlling person in connection with the securities being registered, the Registrant will, unless in the opinion of its counsel
  the matter has been settled by controlling precedent, submit to a court of appropriate jurisdiction the question whether such indemnification
  by it is against public policy as expressed in the Securities Act and will be governed by the final adjudication of such issue.
  II-
  3
  SIGNATURES
  Pursuant to the requirements of the Securities
  Act of 1933, the Registrant certifies that it has reasonable grounds to believe that it meets all the requirements for filing on Form S-8
  and has duly caused this Registration Statement to be signed on its behalf by the undersigned, thereunto duly authorized, in the City
  of Phoenix, State of Arizona, on August 16, 2021.
  SENESTECH, INC.
  By:
  /s/ Kenneth Siegel
  Kenneth Siegel
  Chief Executive Officer
  POWER OF ATTORNEY
  Each person whose signature appears below authorizes
  Kenneth Siegel and Thomas C. Chesterman, or either of them, as attorneys-in-fact with full power of substitution, to execute in the name
  and on the behalf of each person, individually and in each capacity stated below, and to file, any and all amendments to this Registration
  Statement, including any and all post-effective amendments.
  Pursuant to the requirements of the Securities
  Act of 1933, this Registration Statement has been signed by the following persons in the capacities indicated below on August 16, 2021.
  Signature
  Title
  /s/ Kenneth Siegel
  Chief Executive Officer and Director
  Kenneth Siegel
  (Principal Executive Officer)
  /s/ Thomas C. Chesterman
  Chief Financial Officer and Treasurer
  Thomas C. Chesterman
  (Principal Financial and Accounting Officer)
  /s/ Jamie Bechtel
  Chair of the Board
  Jamie Bechtel
  /s/ Delphine François Chiavarini
  Director
  Delphine François Chiavarini
  /s/ Marc Dumont
  Director
  Marc Dumont
  /s/ Phil Grandinetti III
  Director
  Phil Grandinetti III
  /s/ K.C. Kavanagh
  Director
  K.C. Kavanagh
  /s/ Jake Leach
  Director
  Jake Leach
  /s/ Matthew K. Szot
  Director
  Matthew K. Szot
  II-4