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  <!-- Field: Rule-Page --><DIV STYLE="margin-top: 0; margin-bottom: 0; width: 100%"><DIV STYLE="font-size: 1pt; border-top: Black 2pt solid; border-bottom: Black 1pt solid">&nbsp;</DIV></DIV><!-- Field: /Rule-Page -->
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center">As filed with the Securities and Exchange Commission
  on August 11, 2020</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: right">Registration No. 333-&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</P>
  
  <!-- Field: Rule-Page --><DIV STYLE="margin-top: 1pt; margin-bottom: 1pt; width: 100%"><DIV STYLE="font-size: 1pt; border-top: black 2.25pt solid">&nbsp;</DIV></DIV><!-- Field: /Rule-Page -->
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center"><B>UNITED STATES</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center"><B>SECURITIES AND EXCHANGE COMMISSION</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center"><B>WASHINGTON, DC 20549</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center"><B>&nbsp;</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center"><B>FORM S-8</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center"><B>&nbsp;</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center"><B>REGISTRATION STATEMENT UNDER THE</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center"><B>SECURITIES ACT OF 1933</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center"><B>&nbsp;</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center"><B>ORAMED PHARMACEUTICALS INC.</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center">(Exact Name of Registrant as Specified in Its
  Charter)</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center">&nbsp;</P>
  
  <TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
  <TR STYLE="vertical-align: top">
      <TD STYLE="border-bottom: black 1.5pt solid; font-size: 10pt; text-align: center"><FONT STYLE="font-size: 10pt"><B>Delaware</B></FONT></TD>
      <TD STYLE="font-size: 10pt; text-align: center">&nbsp;</TD>
      <TD STYLE="border-bottom: black 1.5pt solid; font-size: 10pt; text-align: center"><FONT STYLE="font-size: 10pt"><B>98-0376008</B></FONT></TD></TR>
  <TR STYLE="vertical-align: top">
      <TD STYLE="width: 49%">
          <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center">(State or Other Jurisdiction of</P>
          <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center">Incorporation or Organization)</P></TD>
      <TD STYLE="width: 2%; font-size: 10pt; text-align: center">&nbsp;</TD>
      <TD STYLE="width: 49%">
          <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center">(I.R.S. Employer</P>
          <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center">Identification No.)</P></TD></TR>
  </TABLE>
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center">&nbsp;</P>
  
  <TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
  <TR>
      <TD STYLE="vertical-align: top; width: 49%; border-bottom: black 1.5pt solid; text-align: center"><FONT STYLE="font-size: 10pt"><B>1185
      Avenue of the Americas, Third Floor, <BR>
  New York, New York</B></FONT></TD>
      <TD STYLE="vertical-align: top; width: 2%; text-align: center">&nbsp;</TD>
      <TD STYLE="vertical-align: bottom; width: 49%; border-bottom: black 1.5pt solid; text-align: center"><FONT STYLE="font-size: 10pt"><B>10036</B></FONT></TD></TR>
  <TR STYLE="vertical-align: top">
      <TD STYLE="text-align: center"><FONT STYLE="font-size: 10pt">(Address of Principal Executive Offices)</FONT></TD>
      <TD STYLE="text-align: center">&nbsp;</TD>
      <TD STYLE="text-align: center"><FONT STYLE="font-size: 10pt">(Zip Code)</FONT></TD></TR>
  </TABLE>
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center"><B>Oramed Pharmaceuticals Inc. Amended and Restated
  2019 Stock Incentive Plan</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center">(Full Title of the Plan)</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center"><B>Vcorp Services, LLC</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center"><B>1811 Silverside Road</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center"><B>Wilmington, Delaware 19810</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center">(Name and address of agent for service)</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center"><B>(888) 528 2677</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center">(Telephone number, including area code, of agent
  for service)</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center"><B>Copies to:</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center">Oded Har-Even, Esq.</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center">Howard E. Berkenblit, Esq.</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center">Sullivan &amp; Worcester LLP</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center">1633 Broadway</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center">New York, NY 10019</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center">Telephone: (212) 660-3000</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center">Facsimile: (212) 660-3001</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center">&nbsp;</P>
  
  <!-- Field: Rule-Page --><DIV STYLE="margin-top: 1pt; margin-bottom: 1pt; width: 100%"><DIV STYLE="font-size: 1pt; border-top: black 1.5pt solid">&nbsp;</DIV></DIV><!-- Field: /Rule-Page -->
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify">Indicate by check mark whether the registrant
  is a large accelerated filer, an accelerated filer, a non-accelerated filer, a smaller reporting company or an emerging growth
  company. See the definitions of &ldquo;large accelerated filer,&rdquo; &ldquo;accelerated filer&rdquo;, &ldquo;smaller reporting
  company,&rdquo; and &ldquo;emerging growth company&rdquo; in Rule&nbsp;12b-2 of the Exchange Act.</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>
  
  <TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
  <TR STYLE="vertical-align: top">
      <TD STYLE="width: 40%; padding-right: 0.8pt"><FONT STYLE="font-size: 10pt">Large accelerated filer&nbsp; &#9744;</FONT></TD>
      <TD STYLE="width: 15%; padding-right: 0.8pt">&nbsp;</TD>
      <TD STYLE="width: 45%; padding-right: 0.8pt"><FONT STYLE="font-size: 10pt">Accelerated filer&nbsp; &#9744;</FONT></TD></TR>
  <TR STYLE="vertical-align: top">
      <TD STYLE="padding-right: 0.8pt"><FONT STYLE="font-size: 10pt">Non-accelerated filer&nbsp; &#9746;</FONT></TD>
      <TD STYLE="padding-right: 0.8pt">&nbsp;</TD>
      <TD>
          <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0 0.8pt 0 0">Smaller reporting company&nbsp; &#9746;</P>
          <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0 0.8pt 0 0">Emerging growth company &#9744;</P></TD></TR>
  </TABLE>
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify">If an emerging growth company, indicate by
  check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial
  accounting standards provided pursuant to Section 7(a)(2)(B) of the Securities Act. &#9744;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center"></P>
  
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  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center"><B>CALCULATION OF REGISTRATION FEE</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center">&nbsp;</P>
  
  <TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
  <TR STYLE="vertical-align: bottom">
      <TD STYLE="border-bottom: black 1.5pt solid"><FONT STYLE="font-size: 10pt"><B>Title of Securities to be Registered</B></FONT></TD>
      <TD STYLE="padding-bottom: 1.5pt">&nbsp;</TD>
      <TD COLSPAN="2" STYLE="border-bottom: black 1.5pt solid"><P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0"><B>&nbsp;</B></P>
          <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center"><B>Amount to be Registered<SUP>(1)</SUP></B></P></TD>
      <TD STYLE="padding-bottom: 1.5pt; text-align: center">&nbsp;</TD>
      <TD STYLE="padding-bottom: 1.5pt; text-align: center">&nbsp;</TD>
      <TD COLSPAN="2" STYLE="border-bottom: black 1.5pt solid; text-align: center"><FONT STYLE="font-size: 10pt"><B>Proposed maximum
      offering price per share<SUP>(2)</SUP></B></FONT></TD>
      <TD STYLE="padding-bottom: 1.5pt; text-align: center">&nbsp;</TD>
      <TD STYLE="padding-bottom: 1.5pt; text-align: center">&nbsp;</TD>
      <TD COLSPAN="2" STYLE="border-bottom: black 1.5pt solid; text-align: center"><FONT STYLE="font-size: 10pt"><B>Proposed maximum
      aggregate offering price<SUP>(2)</SUP></B></FONT></TD>
      <TD STYLE="padding-bottom: 1.5pt; text-align: center">&nbsp;</TD>
      <TD STYLE="padding-bottom: 1.5pt; text-align: center">&nbsp;</TD>
      <TD COLSPAN="2" STYLE="border-bottom: black 1.5pt solid; text-align: center"><FONT STYLE="font-size: 10pt"><B>Amount of registration
      fee</B></FONT></TD>
      <TD STYLE="padding-bottom: 1.5pt">&nbsp;</TD></TR>
  <TR STYLE="background-color: #CCEEFF">
      <TD STYLE="vertical-align: top; width: 51.22%"><FONT STYLE="font-size: 10pt">Common Stock, $0.012 par value per share</FONT></TD>
      <TD STYLE="vertical-align: bottom; width: 0.54%">&nbsp;</TD>
      <TD STYLE="vertical-align: bottom; width: 1.18%">&nbsp;</TD>
      <TD STYLE="vertical-align: bottom; width: 10.56%; text-align: right"><FONT STYLE="font-size: 10pt">2,000,000</FONT></TD>
      <TD STYLE="vertical-align: bottom; width: 0.54%">&nbsp;</TD>
      <TD STYLE="vertical-align: bottom; width: 0.54%">&nbsp;</TD>
      <TD STYLE="vertical-align: bottom; width: 1.08%"><FONT STYLE="font-size: 10pt">$</FONT></TD>
      <TD STYLE="vertical-align: bottom; width: 8.34%; text-align: right"><FONT STYLE="font-size: 10pt">3.85</FONT></TD>
      <TD STYLE="white-space: nowrap; vertical-align: bottom; width: 2.12%">&nbsp;</TD>
      <TD STYLE="vertical-align: bottom; width: 0.54%">&nbsp;</TD>
      <TD STYLE="vertical-align: bottom; width: 1.06%"><FONT STYLE="font-size: 10pt">$</FONT></TD>
      <TD STYLE="vertical-align: bottom; width: 8.54%; text-align: right"><FONT STYLE="font-size: 10pt">7,700,000</FONT></TD>
      <TD STYLE="vertical-align: bottom; width: 2%">&nbsp;</TD>
      <TD STYLE="vertical-align: bottom; width: 0.54%">&nbsp;</TD>
      <TD STYLE="vertical-align: bottom; width: 1.06%"><FONT STYLE="font-size: 10pt">$</FONT></TD>
      <TD STYLE="vertical-align: bottom; width: 9.62%; text-align: right"><FONT STYLE="font-size: 10pt">999.46</FONT></TD>
      <TD STYLE="vertical-align: bottom; width: 0.54%">&nbsp;</TD></TR>
  </TABLE>
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>
  
  <TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
  <TR STYLE="vertical-align: top">
      <TD STYLE="width: 0in">&nbsp;</TD>
      <TD STYLE="width: 0.25in"><FONT STYLE="font-size: 10pt">(1)</FONT></TD>
      <TD STYLE="text-align: justify"><FONT STYLE="font-size: 10pt">Pursuant to Rule 416(a) under the Securities Act of 1933, as amended (the &ldquo;Securities Act&rdquo;), the shares being registered hereunder include such indeterminate number of shares of our common stock as may be issued from time to time with respect to the shares being registered hereunder as a result of stock splits, stock dividends or similar transactions.</FONT></TD></TR>
  </TABLE>
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0 0 0 0.5in; text-align: justify">&nbsp;</P>
  
  <TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
  <TR STYLE="vertical-align: top">
      <TD STYLE="width: 0in">&nbsp;</TD>
      <TD STYLE="width: 0.25in"><FONT STYLE="font-size: 10pt">(2)</FONT></TD>
      <TD STYLE="text-align: justify"><FONT STYLE="font-size: 10pt">Estimated solely for the purpose of calculating the registration fee pursuant to Rules 457(c) and 457(h) of the Securities Act and based upon the average of the high and low prices of the registrant&rsquo;s common stock as reported on the Nasdaq Capital Market on August 7, 2020.</FONT></TD></TR>
  </TABLE>
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0 0 0 0.5in; text-align: justify">&nbsp;</P>
  
  <TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
  <TR STYLE="vertical-align: top">
      <TD STYLE="width: 0in">&nbsp;</TD>
      <TD STYLE="width: 0.25in"><FONT STYLE="font-size: 10pt">(3)</FONT></TD>
      <TD STYLE="text-align: justify"><FONT STYLE="font-size: 10pt">Computed in accordance with Rule 457(h) promulgated under the Securities Act based on the exercise price of the options underlying the ordinary shares.</FONT></TD></TR>
  </TABLE>
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify">&nbsp;</P>
  
  
  
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0"></P>
  
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  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0"></P>
  
  
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0"></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center; background-color: white"><FONT STYLE="background-color: white"><B>EXPLANATORY
  NOTE</B><BR>
  <BR>
  </FONT></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-indent: 0.5in; background-color: white"><FONT STYLE="background-color: white">On
  October 23, 2019, Oramed Pharmaceuticals Inc. (the &ldquo;Company&rdquo;) filed a Registration Statement on Form S-8 (File No.
  333-234303) (the &ldquo;Original Registration Statement&rdquo;) with the Securities and Exchange Commission (the &ldquo;Commission&rdquo;)</FONT>&nbsp;to
  register an aggregate of 1,000,000 shares of common stock, par value $0.012 per share (&ldquo;Common Stock&rdquo;), of the Company
  that may be issued pursuant to the Company&rsquo;s 2019 Stock Incentive Plan (the &ldquo;2019 Plan&rdquo;). The Company is filing
  this Registration Statement on Form S-8 to register an additional 2,000,000 shares of Common Stock of the Company, which may be
  issued in connection with securities awards which may hereafter be granted under the 2019 Plan, as amended and restated.</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; background-color: white">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-indent: 0.5in; background-color: white">Pursuant to General
  Instruction E to Form S-8, the contents of the Original Registration Statement are incorporated herein by reference, except for
  Item 3 and Item 8 of Part II of the Original Registration Statement, which are being updated by this registration statement.</P>
  
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  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; background-color: white"></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-indent: 0.5in; background-color: white">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center"><FONT STYLE="text-transform: uppercase"><B>PART
  II</B></FONT></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify"><FONT STYLE="text-transform: uppercase"><B>&nbsp;</B></FONT></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify"><FONT STYLE="text-transform: uppercase"><B>INFORMATION
  REQUIRED IN THE REGISTRATION STATEMENT</B></FONT></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify"><B>Item 3. Incorporation of Documents by Reference</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify; text-indent: 0.5in">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify; text-indent: 0.5in">The following documents,
  which have been filed by us with the Commission, are incorporated by reference in and made a part of this registration statement,
  as of their respective dates:</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify; text-indent: 0.5in">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0 0 0 0.5in; text-align: justify">(a) Our Annual Report on <FONT STYLE="color: #0000EE"><U><A HREF="http://www.sec.gov/Archives/edgar/data/1176309/000121390019024940/f10k2019_oramedpharma.htm">Form 10-K</A></U></FONT> for the fiscal year ended August 31, 2019, filed with the Commission on November 27, 2019;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0 0 0 0.5in; text-align: justify">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0 0 0 0.5in; text-align: justify">(b) Our Quarterly Reports on Form
  10-Q for the quarterly period ended November 30, 2019, filed with the Commission on <A HREF="http://www.sec.gov/Archives/edgar/data/1176309/000121390020000631/f10q1119_oramedpharma.htm">January
  9, 2020</A>; for the quarterly period ended February 29, 2020, filed with the Commission on <A HREF="http://www.sec.gov/Archives/edgar/data/1176309/000121390020008653/f10q0220_oramedpharma.htm">April
  6, 2020</A>; and for the quarterly period ended May&nbsp;31, 2020, filed with the Commission on <A HREF="http://www.sec.gov/Archives/edgar/data/1176309/000121390020016864/f10q0520_oramedpharma.htm">July 7, 2020</A>;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0 0 0 0.5in; text-align: justify">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0 0 0 0.5in; text-align: justify">(c) Our Current Reports on Form
  8-K filed with the Commission on <A HREF="http://www.sec.gov/Archives/edgar/data/1176309/000121390019017287/f8k082919_oramedpharma.htm">September
  5, 2019</A>, <A HREF="http://www.sec.gov/Archives/edgar/data/1176309/000121390019022717/f8k111219_oramedpharma.htm">November 12,
  2019</A>, <A HREF="http://www.sec.gov/Archives/edgar/data/1176309/000121390019025444/f8k120519_oramed.htm">December 6, 2019</A>,
  <A HREF="http://www.sec.gov/Archives/edgar/data/1176309/000121390020004778/ea119019-8k_oramedpharma.htm">February 26, 2020</A>,
  <A HREF="http://www.sec.gov/Archives/edgar/data/1176309/000121390020005018/ea119125-8k_oramed.htm">February 28, 2020</A>, <A HREF="http://www.sec.gov/Archives/edgar/data/1176309/000121390020008913/ea120570-8k_oramedphar.htm">April
  9, 2020</A>, <A HREF="http://www.sec.gov/Archives/edgar/data/1176309/000121390020017505/ea124140-8k_oramedpharma.htm">July 15, 2020</A>, and <A HREF="http://www.sec.gov/Archives/edgar/data/1176309/000121390020020031/ea124938-8k_oramed.htm">August 4, 2020</A>; and</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0 0 0 0.5in; text-align: justify">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0 0 0 0.5in; text-align: justify">(d) The description of our common
  stock contained in our Form 8-A filed with the Commission on <A HREF="http://www.sec.gov/Archives/edgar/data/1176309/000107579303000325/iguanaeighta.txt">May&nbsp;29,
  2003</A>, as updated by our Form 8-A filed with the Commission on <A HREF="http://www.sec.gov/Archives/edgar/data/1176309/000117891313000291/zk1312588.htm">February 7, 2013</A>, including any amendments or reports filed
  for purposes of updating such description.</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0 0 0 0.5in; text-align: justify">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify; text-indent: 0.5in">All documents subsequently
  filed by us with the Commission pursuant to Sections 13(a), 13(c), 14 and 15(d) of the Securities Exchange Act of 1934, as amended,
  prior to the filing of a post-effective amendment which indicates that all securities offered have been sold or which deregisters
  all securities then remaining unsold, shall be deemed to be incorporated by reference in this registration statement and to be
  part hereof from the date of filing of such documents.</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify; text-indent: 0.5in">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify; text-indent: 0.5in">Any statement contained
  in a document incorporated or deemed to be incorporated by reference herein shall be deemed to be modified or superseded for purposes
  of this registration statement to the extent that a statement herein, or in any subsequently filed document which also is or is
  deemed to be incorporated by reference, modifies or supersedes such statement. Any statement so modified or superseded shall not
  be deemed, except as so modified or superseded, to constitute a part of this registration statement.</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify; text-indent: 0.5in">&nbsp;&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify"><B>Item 8. Exhibits</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-indent: 0.5in">&nbsp;</P>
  
  <TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100.22%; border-collapse: collapse">
  <TR STYLE="vertical-align: top">
      <TD STYLE="width: 9.82%; border-bottom: black 1.5pt solid"><FONT STYLE="font-size: 10pt"><B>Exhibit No.</B></FONT></TD>
      <TD STYLE="width: 0.54%; padding-bottom: 1.5pt">&nbsp;</TD>
      <TD STYLE="border-bottom: black 1.5pt solid; width: 89.64%">
          <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify"><B>&nbsp;</B></P>
          <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify"><B>Description</B></P></TD></TR>
  <TR STYLE="vertical-align: top">
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD STYLE="text-align: justify">&nbsp;</TD></TR>
  <TR STYLE="vertical-align: top; background-color: #CCEEFF">
      <TD>5.1</TD>
      <TD>&nbsp;</TD>
      <TD STYLE="text-align: justify"><A HREF="ea125135-ex5_1.htm">Opinion of Sullivan &amp; Worcester LLP. *</A></TD></TR>
  <TR STYLE="vertical-align: top; background-color: white">
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD STYLE="text-align: justify">&nbsp;</TD></TR>
  <TR STYLE="vertical-align: top; background-color: #CCEEFF">
      <TD>23.1</TD>
      <TD>&nbsp;</TD>
      <TD STYLE="text-align: justify"><A HREF="ea125135-ex5_1.htm">Consent of Sullivan &amp; Worcester LLP (Contained in the opinion of Sullivan &amp; Worcester LLP filed herewith as Exhibit 5.1)</A>.</TD></TR>
  <TR STYLE="vertical-align: top; background-color: white">
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD STYLE="text-align: justify">&nbsp;</TD></TR>
  <TR STYLE="vertical-align: top; background-color: #CCEEFF">
      <TD>23.2</TD>
      <TD>&nbsp;</TD>
      <TD STYLE="text-align: justify"><A HREF="ea125135-ex23_2.htm">Consent of Kesselman &amp; Kesselman, Certified Public Accountants (Isr.), a member firm of PricewaterhouseCoopers International Limited. *</A></TD></TR>
  <TR STYLE="vertical-align: top; background-color: white">
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD STYLE="text-align: justify">&nbsp;</TD></TR>
  <TR STYLE="vertical-align: top; background-color: #CCEEFF">
      <TD>24.1</TD>
      <TD>&nbsp;</TD>
      <TD STYLE="text-align: justify"><A HREF="#poa">Powers of Attorney (Included in the signature page to this registration statement).</A></TD></TR>
  <TR STYLE="vertical-align: top">
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD STYLE="text-align: justify">&nbsp;</TD></TR>
  <TR STYLE="vertical-align: top; background-color: #CCEEFF">
      <TD>99.1</TD>
      <TD>&nbsp;</TD>
      <TD STYLE="text-align: justify"><A HREF="http://www.sec.gov/Archives/edgar/data/1176309/000121390020016305/ea123658-def14a_oramedpharma.htm">Oramed Pharmaceuticals Inc. Amended and Restated 2019 Stock Incentive Plan (Incorporated by reference to Appendix A of the registrant&rsquo;s Definitive Proxy Statement on Schedule 14A filed with the Commission on June 30, 2020).</A></TD></TR>
  </TABLE>
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">&nbsp;&nbsp;</P>
  
  <TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
  <TR STYLE="vertical-align: top">
      <TD STYLE="width: 0in; text-align: justify">&nbsp;</TD>
      <TD STYLE="width: 0.25in"><FONT STYLE="font-size: 10pt">*</FONT></TD>
      <TD STYLE="text-align: justify"><FONT STYLE="font-size: 10pt">filed herewith</FONT></TD></TR>
  </TABLE>
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center">&nbsp;</P>
  
  
  
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0"></P>
  
  <!-- Field: Page; Sequence: 4 -->
      <DIV STYLE="text-align: center; margin-top: 12pt; margin-bottom: 6pt; border-bottom: Black 1.5pt solid">1</DIV>
      <DIV STYLE="page-break-before: always; margin-top: 6pt; margin-bottom: 12pt">&nbsp;</DIV>
      <!-- Field: /Page -->
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0"><B></B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center"><B>SIGNATURES</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify; text-indent: 0.5in">Pursuant to the requirements
  of the Securities Act of 1933, the registrant certifies that it has reasonable grounds to believe that it meets all of the requirements
  for filing on Form S-8 and has duly caused this registration statement to be signed on its behalf by the undersigned, thereunto
  duly authorized, in New York, New York, on August 11, 2020.</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify; text-indent: 0.5in">&nbsp;</P>
  
  <TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
  <TR STYLE="vertical-align: top">
      <TD>&nbsp;</TD>
      <TD COLSPAN="2"><FONT STYLE="font-size: 10pt"><B>ORAMED PHARMACEUTICALS INC.</B></FONT></TD></TR>
  <TR STYLE="vertical-align: top">
      <TD>&nbsp;</TD>
      <TD COLSPAN="2">&nbsp;</TD></TR>
  <TR STYLE="vertical-align: top">
      <TD STYLE="width: 60%">&nbsp;</TD>
      <TD STYLE="width: 5%"><FONT STYLE="font-size: 10pt">By:</FONT></TD>
      <TD STYLE="width: 35%; border-bottom: black 1.5pt solid"><FONT STYLE="font-size: 10pt">/s/ Nadav Kidron</FONT></TD></TR>
  <TR STYLE="vertical-align: top">
      <TD>&nbsp;</TD>
      <TD><FONT STYLE="font-size: 10pt">Name:&nbsp;</FONT></TD>
      <TD><FONT STYLE="font-size: 10pt">Nadav Kidron</FONT></TD></TR>
  <TR STYLE="vertical-align: top">
      <TD>&nbsp;</TD>
      <TD><FONT STYLE="font-size: 10pt">Title:</FONT></TD>
      <TD><FONT STYLE="font-size: 10pt">President and Chief Executive Officer</FONT></TD></TR>
  </TABLE>
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify; text-indent: 0.5in">Each person whose signature
  appears below authorizes each of Nadav Kidron and Avraham Gabay, or either of them acting individually, as his or her true and
  lawful attorney-in-fact, each with full power of substitution, to sign the Registration Statement on Form S-8 of Oramed Pharmaceuticals
  Inc., including any and all post-effective amendments, in the name and on behalf of each such person, individually and in each
  capacity stated below, and to file the same, with exhibits thereto and other documents in connection therewith with the Securities
  and Exchange Commission.</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify; text-indent: 0.5in">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify; text-indent: 0.5in"><A NAME="poa"></A>Pursuant to the requirements
  of the Securities Act of 1933, this registration statement on Form S-8 has been signed below by the following persons in the capacities
  and on the dates indicated.</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify; text-indent: 0.5in">&nbsp;</P>
  
  <TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
  <TR STYLE="vertical-align: top">
      <TD STYLE="width: 24%; border-bottom: black 1.5pt solid; text-align: center"><FONT STYLE="font-size: 10pt"><B>Signature</B></FONT></TD>
      <TD STYLE="width: 2%; padding-bottom: 1.5pt">&nbsp;</TD>
      <TD STYLE="width: 48%; border-bottom: black 1.5pt solid; text-align: center"><FONT STYLE="font-size: 10pt"><B>Title</B></FONT></TD>
      <TD STYLE="width: 2%; padding-bottom: 1.5pt">&nbsp;</TD>
      <TD STYLE="width: 24%; border-bottom: black 1.5pt solid; text-align: center"><FONT STYLE="font-size: 10pt"><B>Date</B></FONT></TD></TR>
  <TR STYLE="vertical-align: top">
      <TD STYLE="text-align: center">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD STYLE="text-align: center">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD STYLE="text-align: center">&nbsp;</TD></TR>
  <TR>
      <TD STYLE="vertical-align: bottom; border-bottom: black 1.5pt solid"><FONT STYLE="font-size: 10pt">/s/ Nadav Kidron</FONT></TD>
      <TD>&nbsp;</TD>
      <TD STYLE="vertical-align: bottom">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD STYLE="text-align: center"><FONT STYLE="font-size: 10pt">August 11, 2020</FONT></TD></TR>
  <TR STYLE="vertical-align: top">
      <TD><FONT STYLE="font-size: 10pt">Nadav Kidron</FONT></TD>
      <TD>&nbsp;</TD>
      <TD><FONT STYLE="font-size: 10pt">President, Chief Executive Officer and Director (Principal Executive Officer)</FONT></TD>
      <TD>&nbsp;</TD>
      <TD STYLE="text-align: center">&nbsp;</TD></TR>
  <TR STYLE="vertical-align: top">
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD STYLE="text-align: center">&nbsp;</TD></TR>
  <TR>
      <TD STYLE="vertical-align: bottom; border-bottom: black 1.5pt solid"><FONT STYLE="font-size: 10pt">/s/ Avraham Gabay</FONT></TD>
      <TD>&nbsp;</TD>
      <TD STYLE="vertical-align: bottom">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD STYLE="text-align: center"><FONT STYLE="font-size: 10pt">August 11, 2020</FONT></TD></TR>
  <TR STYLE="vertical-align: top">
      <TD><FONT STYLE="font-size: 10pt">Avraham Gabay</FONT></TD>
      <TD>&nbsp;</TD>
      <TD><FONT STYLE="font-size: 10pt">Chief Financial Officer, Treasurer and Secretary (Principal Financial Officer and Principal Accounting Officer)</FONT></TD>
      <TD>&nbsp;</TD>
      <TD STYLE="text-align: center">&nbsp;</TD></TR>
  <TR STYLE="vertical-align: top">
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD STYLE="text-align: center">&nbsp;</TD></TR>
  <TR>
      <TD STYLE="vertical-align: bottom; border-bottom: black 1.5pt solid"><FONT STYLE="font-size: 10pt">/s/ Aviad Friedman</FONT></TD>
      <TD>&nbsp;</TD>
      <TD STYLE="vertical-align: bottom">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD STYLE="text-align: center"><FONT STYLE="font-size: 10pt">August 11, 2020</FONT></TD></TR>
  <TR STYLE="vertical-align: top">
      <TD><FONT STYLE="font-size: 10pt">Aviad Friedman</FONT></TD>
      <TD>&nbsp;</TD>
      <TD><FONT STYLE="font-size: 10pt">Director</FONT></TD>
      <TD>&nbsp;</TD>
      <TD STYLE="text-align: center">&nbsp;</TD></TR>
  <TR STYLE="vertical-align: top">
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD STYLE="text-align: center">&nbsp;</TD></TR>
  <TR>
      <TD STYLE="vertical-align: bottom; border-bottom: black 1.5pt solid"><FONT STYLE="font-size: 10pt">/s/ Miriam Kidron</FONT></TD>
      <TD>&nbsp;</TD>
      <TD STYLE="vertical-align: bottom">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD STYLE="text-align: center"><FONT STYLE="font-size: 10pt">August 11, 2020</FONT></TD></TR>
  <TR STYLE="vertical-align: top">
      <TD><FONT STYLE="font-size: 10pt">Miriam Kidron</FONT></TD>
      <TD>&nbsp;</TD>
      <TD><FONT STYLE="font-size: 10pt">Director</FONT></TD>
      <TD>&nbsp;</TD>
      <TD STYLE="text-align: center">&nbsp;</TD></TR>
  <TR STYLE="vertical-align: top">
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD STYLE="text-align: center">&nbsp;</TD></TR>
  <TR>
      <TD STYLE="vertical-align: bottom; border-bottom: black 1.5pt solid"><FONT STYLE="font-size: 10pt">/s/ Arie Mayer</FONT></TD>
      <TD>&nbsp;</TD>
      <TD STYLE="vertical-align: bottom">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD STYLE="text-align: center"><FONT STYLE="font-size: 10pt">August 11, 2020</FONT></TD></TR>
  <TR STYLE="vertical-align: top">
      <TD><FONT STYLE="font-size: 10pt">Arie Mayer</FONT></TD>
      <TD>&nbsp;</TD>
      <TD><FONT STYLE="font-size: 10pt">Director</FONT></TD>
      <TD>&nbsp;</TD>
      <TD STYLE="text-align: center">&nbsp;</TD></TR>
  <TR STYLE="vertical-align: top">
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD STYLE="text-align: center">&nbsp;</TD></TR>
  <TR>
      <TD STYLE="vertical-align: bottom; border-bottom: black 1.5pt solid"><FONT STYLE="font-size: 10pt">/s/ Kevin Rakin</FONT></TD>
      <TD>&nbsp;</TD>
      <TD STYLE="vertical-align: bottom">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD STYLE="text-align: center"><FONT STYLE="font-size: 10pt">August 11, 2020</FONT></TD></TR>
  <TR STYLE="vertical-align: top">
      <TD><FONT STYLE="font-size: 10pt">Kevin Rakin</FONT></TD>
      <TD>&nbsp;</TD>
      <TD><FONT STYLE="font-size: 10pt">Director</FONT></TD>
      <TD>&nbsp;</TD>
      <TD STYLE="text-align: center">&nbsp;</TD></TR>
  <TR STYLE="vertical-align: top">
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD STYLE="text-align: center">&nbsp;</TD></TR>
  <TR>
      <TD STYLE="vertical-align: bottom; border-bottom: black 1.5pt solid"><FONT STYLE="font-size: 10pt">/s/ Leonard Sank</FONT></TD>
      <TD>&nbsp;</TD>
      <TD STYLE="vertical-align: bottom">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD STYLE="text-align: center"><FONT STYLE="font-size: 10pt">August 11, 2020</FONT></TD></TR>
  <TR STYLE="vertical-align: top">
      <TD><FONT STYLE="font-size: 10pt">Leonard Sank</FONT></TD>
      <TD>&nbsp;</TD>
      <TD><FONT STYLE="font-size: 10pt">Director</FONT></TD>
      <TD>&nbsp;</TD>
      <TD STYLE="text-align: center">&nbsp;</TD></TR>
  <TR STYLE="vertical-align: top">
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD STYLE="text-align: center">&nbsp;</TD></TR>
  <TR STYLE="vertical-align: top">
      <TD STYLE="border-bottom: black 1.5pt solid; vertical-align: bottom">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD><P STYLE="margin: 0; font: 10pt Times New Roman, Times, Serif">Director</P></TD>
      <TD>&nbsp;</TD>
      <TD STYLE="text-align: center">August 11, 2020</TD></TR>
  <TR STYLE="vertical-align: top">
      <TD><P STYLE="margin: 0; font: 10pt Times New Roman, Times, Serif">Gao Xiaoming</P></TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD STYLE="text-align: center">&nbsp;</TD></TR>
  </TABLE>
  
  
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0"></P>
  
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metadata_documents: [{"type": "S-8", "sequence": "1", "filename": "ea125135-s8_oramed.htm", "description": "FORM S-8", "secsgml_size_bytes": 38697}]
metadata_filer: {"company-data": {"conformed-name": "ORAMED PHARMACEUTICALS INC.", "cik": "0001176309", "assigned-sic": "2834", "irs-number": "980376008", "state-of-incorporation": "DE", "fiscal-year-end": "0831"}, "filing-values": {"form-type": "S-8", "act": "33", "file-number": "333-244380", "film-number": "201092964"}, "business-address": {"street1": "1185 AVENUE OF THE AMERICAS, 3RD FLOOR", "city": "NEW YORK", "state": "NY", "zip": "10036", "phone": "646-844-1164"}, "mail-address": {"street1": "1185 AVENUE OF THE AMERICAS, 3RD FLOOR", "city": "NEW YORK", "state": "NY", "zip": "10036"}, "former-company": [{"former-conformed-name": "Integrated Security Technologies, Inc.", "date-changed": "20040614"}, {"former-conformed-name": "IGUANA VENTURES LTD", "date-changed": "20020625"}]}
text: As filed with the Securities and Exchange Commission
  on August 11, 2020
  Registration No. 333-
  UNITED STATES
  SECURITIES AND EXCHANGE COMMISSION
  WASHINGTON, DC 20549
  FORM S-8
  REGISTRATION STATEMENT UNDER THE
  SECURITIES ACT OF 1933
  ORAMED PHARMACEUTICALS INC.
  (Exact Name of Registrant as Specified in Its
  Charter)
  Delaware
  98-0376008
  (State or Other Jurisdiction of
  Incorporation or Organization)
  (I.R.S. Employer
  Identification No.)
  1185
      Avenue of the Americas, Third Floor,
  New York, New York
  10036
  (Address of Principal Executive Offices)
  (Zip Code)
  Oramed Pharmaceuticals Inc. Amended and Restated
  2019 Stock Incentive Plan
  (Full Title of the Plan)
  Vcorp Services, LLC
  1811 Silverside Road
  Wilmington, Delaware 19810
  (Name and address of agent for service)
  (888) 528 2677
  (Telephone number, including area code, of agent
  for service)
  Copies to:
  Oded Har-Even, Esq.
  Howard E. Berkenblit, Esq.
  Sullivan & Worcester LLP
  1633 Broadway
  New York, NY 10019
  Telephone: (212) 660-3000
  Facsimile: (212) 660-3001
  Indicate by check mark whether the registrant
  is a large accelerated filer, an accelerated filer, a non-accelerated filer, a smaller reporting company or an emerging growth
  company. See the definitions of "large accelerated filer," "accelerated filer", "smaller reporting
  company," and "emerging growth company" in Rule 12b-2 of the Exchange Act.
  Large accelerated filer  ☐
  Accelerated filer  ☐
  Non-accelerated filer  ☒
  Smaller reporting company  ☒
  Emerging growth company ☐
  If an emerging growth company, indicate by
  check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial
  accounting standards provided pursuant to Section 7(a)(2)(B) of the Securities Act. ☐
  CALCULATION OF REGISTRATION FEE
  Title of Securities to be Registered
  Amount to be Registered
  (1)
  Proposed maximum
      offering price per share
  (2)
  Proposed maximum
      aggregate offering price
  (2)
  Amount of registration
      fee
  Common Stock, $0.012 par value per share
  2,000,000
  $
  3.85
  $
  7,700,000
  $
  999.46
  (1)
  Pursuant to Rule 416(a) under the Securities Act of 1933, as amended (the "Securities Act"), the shares being registered hereunder include such indeterminate number of shares of our common stock as may be issued from time to time with respect to the shares being registered hereunder as a result of stock splits, stock dividends or similar transactions.
  (2)
  Estimated solely for the purpose of calculating the registration fee pursuant to Rules 457(c) and 457(h) of the Securities Act and based upon the average of the high and low prices of the registrant's common stock as reported on the Nasdaq Capital Market on August 7, 2020.
  (3)
  Computed in accordance with Rule 457(h) promulgated under the Securities Act based on the exercise price of the options underlying the ordinary shares.
  EXPLANATORY
  NOTE
  On
  October 23, 2019, Oramed Pharmaceuticals Inc. (the "Company") filed a Registration Statement on Form S-8 (File No.
  333-234303) (the "Original Registration Statement") with the Securities and Exchange Commission (the "Commission")
  to
  register an aggregate of 1,000,000 shares of common stock, par value $0.012 per share ("Common Stock"), of the Company
  that may be issued pursuant to the Company's 2019 Stock Incentive Plan (the "2019 Plan"). The Company is filing
  this Registration Statement on Form S-8 to register an additional 2,000,000 shares of Common Stock of the Company, which may be
  issued in connection with securities awards which may hereafter be granted under the 2019 Plan, as amended and restated.
  Pursuant to General
  Instruction E to Form S-8, the contents of the Original Registration Statement are incorporated herein by reference, except for
  Item 3 and Item 8 of Part II of the Original Registration Statement, which are being updated by this registration statement.
  PART
  II
  INFORMATION
  REQUIRED IN THE REGISTRATION STATEMENT
  Item 3. Incorporation of Documents by Reference
  The following documents,
  which have been filed by us with the Commission, are incorporated by reference in and made a part of this registration statement,
  as of their respective dates:
  (a) Our Annual Report on
  Form 10-K
  for the fiscal year ended August 31, 2019, filed with the Commission on November 27, 2019;
  (b) Our Quarterly Reports on Form
  10-Q for the quarterly period ended November 30, 2019, filed with the Commission on
  January
  9, 2020
  ; for the quarterly period ended February 29, 2020, filed with the Commission on
  April
  6, 2020
  ; and for the quarterly period ended May 31, 2020, filed with the Commission on
  July 7, 2020
  ;
  (c) Our Current Reports on Form
  8-K filed with the Commission on
  September
  5, 2019
  ,
  November 12,
  2019
  ,
  December 6, 2019
  ,
  February 26, 2020
  ,
  February 28, 2020
  ,
  April
  9, 2020
  ,
  July 15, 2020
  , and
  August 4, 2020
  ; and
  (d) The description of our common
  stock contained in our Form 8-A filed with the Commission on
  May 29,
  2003
  , as updated by our Form 8-A filed with the Commission on
  February 7, 2013
  , including any amendments or reports filed
  for purposes of updating such description.
  All documents subsequently
  filed by us with the Commission pursuant to Sections 13(a), 13(c), 14 and 15(d) of the Securities Exchange Act of 1934, as amended,
  prior to the filing of a post-effective amendment which indicates that all securities offered have been sold or which deregisters
  all securities then remaining unsold, shall be deemed to be incorporated by reference in this registration statement and to be
  part hereof from the date of filing of such documents.
  Any statement contained
  in a document incorporated or deemed to be incorporated by reference herein shall be deemed to be modified or superseded for purposes
  of this registration statement to the extent that a statement herein, or in any subsequently filed document which also is or is
  deemed to be incorporated by reference, modifies or supersedes such statement. Any statement so modified or superseded shall not
  be deemed, except as so modified or superseded, to constitute a part of this registration statement.
  Item 8. Exhibits
  Exhibit No.
  Description
  5.1
  Opinion of Sullivan & Worcester LLP. *
  23.1
  Consent of Sullivan & Worcester LLP (Contained in the opinion of Sullivan & Worcester LLP filed herewith as Exhibit 5.1)
  .
  23.2
  Consent of Kesselman & Kesselman, Certified Public Accountants (Isr.), a member firm of PricewaterhouseCoopers International Limited. *
  24.1
  Powers of Attorney (Included in the signature page to this registration statement).
  99.1
  Oramed Pharmaceuticals Inc. Amended and Restated 2019 Stock Incentive Plan (Incorporated by reference to Appendix A of the registrant's Definitive Proxy Statement on Schedule 14A filed with the Commission on June 30, 2020).
  *
  filed herewith
  1
  SIGNATURES
  Pursuant to the requirements
  of the Securities Act of 1933, the registrant certifies that it has reasonable grounds to believe that it meets all of the requirements
  for filing on Form S-8 and has duly caused this registration statement to be signed on its behalf by the undersigned, thereunto
  duly authorized, in New York, New York, on August 11, 2020.
  ORAMED PHARMACEUTICALS INC.
  By:
  /s/ Nadav Kidron
  Name:
  Nadav Kidron
  Title:
  President and Chief Executive Officer
  Each person whose signature
  appears below authorizes each of Nadav Kidron and Avraham Gabay, or either of them acting individually, as his or her true and
  lawful attorney-in-fact, each with full power of substitution, to sign the Registration Statement on Form S-8 of Oramed Pharmaceuticals
  Inc., including any and all post-effective amendments, in the name and on behalf of each such person, individually and in each
  capacity stated below, and to file the same, with exhibits thereto and other documents in connection therewith with the Securities
  and Exchange Commission.
  Pursuant to the requirements
  of the Securities Act of 1933, this registration statement on Form S-8 has been signed below by the following persons in the capacities
  and on the dates indicated.
  Signature
  Title
  Date
  /s/ Nadav Kidron
  August 11, 2020
  Nadav Kidron
  President, Chief Executive Officer and Director (Principal Executive Officer)
  /s/ Avraham Gabay
  August 11, 2020
  Avraham Gabay
  Chief Financial Officer, Treasurer and Secretary (Principal Financial Officer and Principal Accounting Officer)
  /s/ Aviad Friedman
  August 11, 2020
  Aviad Friedman
  Director
  /s/ Miriam Kidron
  August 11, 2020
  Miriam Kidron
  Director
  /s/ Arie Mayer
  August 11, 2020
  Arie Mayer
  Director
  /s/ Kevin Rakin
  August 11, 2020
  Kevin Rakin
  Director
  /s/ Leonard Sank
  August 11, 2020
  Leonard Sank
  Director
  Director
  August 11, 2020
  Gao Xiaoming
  2