content: <html>
  <head>
  <title>Untitled Document</title>
  </head>
  
  <body>
  <P ALIGN="CENTER"><FONT FACE="Times New Roman, Times, Serif"><FONT SIZE="2"><B>As filed with
  the Securities and Exchange Commission on September 16, 2005<BR>Registration No. 333-_
  ______</B></FONT></FONT> </P>
  
  
  
  <P ALIGN="CENTER"><FONT FACE="Times New Roman, Times, Serif"><FONT SIZE="3">UNITED STATES<BR>
  SECURITIES AND EXCHANGE COMMISSION<BR>Washington, D.C. 20549</FONT></FONT> </P>
  
  <P ALIGN="CENTER"><FONT FACE="Times New Roman, Times, Serif"><FONT SIZE="5"><B>FORM S-8</B></FONT></FONT> </P>
  
  <P ALIGN="CENTER"><FONT FACE="Times New Roman, Times, Serif"><FONT SIZE="2">REGISTRATION
  STATEMENT<BR>UNDER<BR>THE SECURITIES ACT OF 1933</FONT></FONT> </P>
  <P ALIGN="CENTER"><FONT FACE="Times New Roman, Times, Serif"><FONT SIZE="5"><B>GENTA
  INCORPORATED</B><BR>
  <font size="2">(Exact Name of Registrant as Specified in Its Charter)</font></FONT></FONT> </P>
  
  <table width="100%" border="0" align="center" cellpadding="0" cellspacing="0">
    <tr align="center" valign="bottom">
      <td width="33%"><font size="2" face="Times New Roman, Times, serif"><b>Delaware</b></font></td>
      <td><b><font size="2" face="Times New Roman, Times, serif">2836</font></b></td>
      <td width="33%"><b><font size="2" face="Times New Roman, Times, serif">33-0326866</font></b></td>
    </tr>
    <tr align="center" valign="top">
      <td><font size="2" face="Times New Roman, Times, serif">(State or other
        jurisdiction of
        incorporation or organization) </font></td>
      <td><font size="2" face="Times New Roman, Times, serif">(Primary Standard Industrial Classification
  Code Number) <br>
      </font></td>
      <td><font size="2" face="Times New Roman, Times, serif">(I.R.S. Employer
  
        Identification Number)</font></td>
    </tr>
    <tr align="center" valign="top">
      <td>&nbsp;</td>
      <td>&nbsp;</td>
      <td>&nbsp;</td>
    </tr>
    <tr align="center" valign="bottom">
      <td>&nbsp;</td>
      <td><b><font size="2" face="Times New Roman, Times, serif"> Two Connell Drive <br>
        Berkeley Heights, NJ 07922<br>
  (908) 286-9800 <br>
      </font></b></td>
      <td>&nbsp;</td>
    </tr>
    <tr align="center" valign="top">
      <td colspan="3"><font size="2" face="Times New Roman, Times, serif">(Address, Including Zip Code, and Telephone Number, Including Area Code, of Registrant&#146;s Principal Executive Offices)</font></td>
    </tr>
  </table>
  
      <BR>
  
  
  
  
  <P ALIGN="CENTER"><FONT FACE="Times New Roman, Times, Serif"><FONT SIZE="2"><B>GENTA
  INCORPORATED 1998 NON-EMPLOYEE DIRECTORS&#146; STOCK OPTION PLAN</B><BR>(Full title of the plan)</FONT></FONT> </P>
  
  
  <P ALIGN="CENTER"><FONT FACE="Times New Roman, Times, Serif"><FONT SIZE="2"><B>William P.
  Keane<BR>Senior Vice President, Chief Financial Officer<BR>and Corporate Secretary<BR>Genta
  Incorporated<BR>Two Connell Drive
  <BR>Berkeley Heights, NJ 07922
  <BR>(908) 286-9800</B><BR>(Name, Address, Including Zip
           Code, and Telephone Number, Including Area Code, of
           Agent For Service)</FONT></FONT> </P>
  
  
  
  
  <P ALIGN="CENTER"><FONT FACE="Times New Roman, Times, Serif"><FONT SIZE="2"><B><I>Copy to:</I><BR>
  Richard A. Drucker <BR>Davis Polk &amp; Wardwell<BR> 450 Lexington Avenue<BR> New York, New York
  10017 (212) 450-4000</B></FONT></FONT> </P>
  
  
  <P ALIGN="CENTER"><FONT FACE="Times New Roman, Times, Serif"><FONT SIZE="2"><B>CALCULATION
  OF REGISTRATION FEE</B></FONT></FONT> </P>
  
  
  
  
  <TABLE WIDTH="100%" BORDER="0" align="center" CELLPADDING="0" CELLSPACING="0">
  <TR VALIGN="BOTTOM">
    <TD ALIGN="center"><b><font size="1" face="Times New Roman, Times, serif"> Title Of Each Class <br>
      Of Securities To Be Registered <br>
    </font></b></TD>
    <TD ALIGN="center"><font size="1">&nbsp;</font></TD>
    <TD ALIGN="center"><font size="1">&nbsp;</font></TD>
    <TD ALIGN="center"><font size="1">&nbsp;</font></TD>
    <TD ALIGN="center"><b><font size="1" face="Times New Roman, Times, serif"> Amount To Be <br>
      Registered (1)
    </font></b></TD>
    <TD ALIGN="center"><font size="1">&nbsp;</font></TD>
    <TD colspan="2" ALIGN="center"><b><font size="1" face="Times New Roman, Times, serif">Proposed <br>
  Maximum<br>
  Offering Price<br>
  Per Unit (2)
    </font></b></TD>
    <TD ALIGN="center"><font size="1">&nbsp;</font></TD>
    <TD colspan="2" ALIGN="center"><b><font size="1" face="Times New Roman, Times, serif"> Proposed <br>
  Maximum<br>
  Aggregate <br>
  Offering Price (2)
    </font></b></TD>
    <TD ALIGN="center"><font size="1">&nbsp;</font></TD>
    <TD colspan="2" ALIGN="center"><font size="1">&nbsp;</font> <b><font size="1" face="Times New Roman, Times, serif"><br>
  Amount Of <br>
  Registration Fee<br>
    </font></b></TD>
    <TD ALIGN="LEFT">&nbsp;</TD>
  </TR>
  <TR VALIGN="BOTTOM">
       <TD width="30%" ALIGN="center"><FONT FACE="Times New Roman, Times, Serif" SIZE="2">Common Stock, par value $.001 per share</FONT></TD>
       <TD WIDTH="1%" ALIGN="center"><FONT FACE="Times New Roman, Times, Serif" SIZE="2">&nbsp;</FONT></TD>
       <TD WIDTH="2%" ALIGN="center"><FONT FACE="Times New Roman, Times, Serif" SIZE="2">&nbsp;</FONT></TD>
       <TD WIDTH="1%" ALIGN="center"><FONT FACE="Times New Roman, Times, Serif" SIZE="2">&nbsp;</FONT></TD><TD WIDTH="9%" ALIGN="center"><FONT FACE="Times New Roman, Times, Serif" SIZE="2">500,000</FONT></TD>
          <TD WIDTH="3%" ALIGN="center"><FONT FACE="Times New Roman, Times, Serif" SIZE="2">&nbsp;</FONT></TD>
       <TD WIDTH="1%" ALIGN="center"><FONT FACE="Times New Roman, Times, Serif" SIZE="2">$</FONT></TD><TD WIDTH="9%" ALIGN="center"><FONT FACE="Times New Roman, Times, Serif" SIZE="2">  1.21</FONT></TD>
          <TD WIDTH="2%" ALIGN="center"><FONT FACE="Times New Roman, Times, Serif" SIZE="2">&nbsp;</FONT></TD>
       <TD WIDTH="1%" ALIGN="center"><FONT FACE="Times New Roman, Times, Serif" SIZE="2">$</FONT></TD>
       <TD WIDTH="9%" ALIGN="center"><FONT FACE="Times New Roman, Times, Serif" SIZE="2"> 605,000</FONT></TD>
          <TD WIDTH="3%" ALIGN="center"><FONT FACE="Times New Roman, Times, Serif" SIZE="2">&nbsp;</FONT></TD>
       <TD WIDTH="1%" ALIGN="center"><FONT FACE="Times New Roman, Times, Serif" SIZE="2">$</FONT></TD>
       <TD WIDTH="9%" ALIGN="center"><FONT FACE="Times New Roman, Times, Serif" SIZE="2"> 71.21</FONT></TD>
       <TD WIDTH="2%" ALIGN="LEFT"><FONT FACE="Times New Roman, Times, Serif" SIZE="2">&nbsp;</FONT></TD></TR>
  </TABLE>
  <BR>
  
  
  
  
  <TABLE WIDTH="100%" CELLPADDING="0" CELLSPACING="0">
  <TR VALIGN="TOP">
       <TD ALIGN="LEFT" WIDTH="3%" nowrap><FONT FACE="Times New Roman, Times, Serif"><FONT SIZE="2">
  (1) </FONT></FONT></TD>
       <TD ALIGN="LEFT" WIDTH="3%">&nbsp;</TD>
       <TD WIDTH="94%"><FONT FACE="Times New Roman, Times, Serif"><FONT SIZE="2">
   Pursuant
  to Rule 416 under the Securities Act of 1933,  this  Registration  Statement also covers
  such  additional  shares as may  hereinafter be offered or issued to prevent dilution
  resulting from stock splits,  stock dividends,  stock  recapitalizations  or  certain
  other capital adjustments.<br></FONT></FONT></TD>
  </TR>
  </TABLE>
  <BR>
  
  <TABLE WIDTH="100%" CELLPADDING="0" CELLSPACING="0">
  <TR VALIGN="TOP">
       <TD ALIGN="LEFT" WIDTH="3%" nowrap><FONT FACE="Times New Roman, Times, Serif"><FONT SIZE="2">
  (2) </FONT></FONT></TD>
       <TD ALIGN="LEFT" WIDTH="3%">&nbsp;</TD>
       <TD WIDTH="94%"><FONT FACE="Times New Roman, Times, Serif"><FONT SIZE="2">
   Estimated
  solely for the purpose of computing the amount of the  registration  fee pursuant to Rule
  457(c) under the  Securities  Act of 1933 based on the average of the high and low prices
  of the Common  Stock on the Nasdaq  National  Market on  September 15,  2005.<br>
      </FONT></FONT></TD>
  </TR>
  </TABLE>
  <BR>
  
  
  <hr width="100%" size="2">
  <P align="left" style="page-break-before:always">&nbsp;</P>
  
  
  <P ALIGN="CENTER"><FONT FACE="Times New Roman, Times, Serif"><FONT SIZE="2"><B>PART II</B></FONT></FONT> </P>
  
  <P ALIGN="CENTER"><FONT FACE="Times New Roman, Times, Serif"><FONT SIZE="2"><B>INFORMATION
  REQUIRED IN THE REGISTRATION STATEMENT</B></FONT></FONT> </P>
  
  <P ALIGN="LEFT"><FONT FACE="Times New Roman, Times, Serif"><FONT SIZE="2"><b>Item 3.
  Incorporation of Documents by Reference.</b><br></FONT></FONT> </P>
  
  <P ALIGN="LEFT">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<FONT FACE="Times New Roman, Times, Serif"><FONT SIZE="2">The
  following  documents  filed  by  Genta  Incorporated  (&#147;Genta&#148;)  with  the
  Securities  and  Exchange  Commission  pursuant to the  Securities  Exchange Act of 1934,
  as amended  (the &#147;Exchange Act&#148;),  are  incorporated in this  Registration
  Statement by reference:<br></FONT></FONT> </P>
  
  <TABLE WIDTH="100%" CELLPADDING="0" CELLSPACING="0">
  <TR VALIGN="TOP">
       <TD ALIGN="LEFT" WIDTH="3%" nowrap><FONT FACE="Times New Roman, Times, Serif"><FONT SIZE="2">
  1. </FONT></FONT></TD>
       <TD ALIGN="LEFT" WIDTH="3%">&nbsp;</TD>
       <TD WIDTH="94%"><FONT FACE="Times New Roman, Times, Serif"><FONT SIZE="2">
  Our
  Annual Report on Form 10-K for the fiscal year  ended December 31, 2004.<br></FONT></FONT></TD>
  </TR>
  </TABLE>
  <BR>
  
  <TABLE WIDTH="100%" CELLPADDING="0" CELLSPACING="0">
  <TR VALIGN="TOP">
       <TD ALIGN="LEFT" WIDTH="3%" nowrap><FONT FACE="Times New Roman, Times, Serif"><FONT SIZE="2">
  2. </FONT></FONT></TD>
       <TD ALIGN="LEFT" WIDTH="3%">&nbsp;</TD>
       <TD WIDTH="94%"><FONT FACE="Times New Roman, Times, Serif"><FONT SIZE="2">
  Our
  Quarterly Reports on Form 10-Q and 10-Q/A for the  quarterly periods ended March 31 and
  June 30, 2005.<br></FONT></FONT></TD>
  </TR>
  </TABLE>
  <BR>
  
  <TABLE WIDTH="100%" CELLPADDING="0" CELLSPACING="0">
  <TR VALIGN="TOP">
       <TD ALIGN="LEFT" WIDTH="3%" nowrap><FONT FACE="Times New Roman, Times, Serif"><FONT SIZE="2">
  3. </FONT></FONT></TD>
       <TD ALIGN="LEFT" WIDTH="3%">&nbsp;</TD>
       <TD WIDTH="94%"><FONT FACE="Times New Roman, Times, Serif"><FONT SIZE="2">
  Our
  Current Reports on Form 8-K filed on January 11,  March 15, April 19, April 28, May 5,
  May 10, May 13, May  16, May 17, June 13, June 23, June 30, 2005 and August  8, 2005.<br></FONT></FONT></TD>
  </TR>
  </TABLE>
  <BR>
  
  <TABLE WIDTH="100%" CELLPADDING="0" CELLSPACING="0">
  <TR VALIGN="TOP">
       <TD ALIGN="LEFT" WIDTH="3%" nowrap><FONT FACE="Times New Roman, Times, Serif"><FONT SIZE="2">
  4. </FONT></FONT></TD>
       <TD ALIGN="LEFT" WIDTH="3%">&nbsp;</TD>
       <TD WIDTH="94%"><FONT FACE="Times New Roman, Times, Serif"><FONT SIZE="2">
  The
  description of our shares of common stock contained  in the Registration  Statement on
  Form S-3 that was filed  on April 2, 2004 and any subsequent  amendments  thereto,  or in
  a  Registration  Statement  on Form  8-A,  updating  such description.<br></FONT></FONT></TD>
  </TR>
  </TABLE>
  <BR>
  
  <TABLE WIDTH="100%" CELLPADDING="0" CELLSPACING="0">
  <TR VALIGN="TOP">
       <TD ALIGN="LEFT" WIDTH="3%" nowrap><FONT FACE="Times New Roman, Times, Serif"><FONT SIZE="2">
  5. </FONT></FONT></TD>
       <TD ALIGN="LEFT" WIDTH="3%">&nbsp;</TD>
       <TD WIDTH="94%"><FONT FACE="Times New Roman, Times, Serif"><FONT SIZE="2">
  All
  other  documents  filed by us  pursuant  to Sections  13(a),  13(c),  14  and  15(d)  of
  the  Exchange  Act  subsequent  to the  date of this  Registration  Statement  and  prior
  to the  filing of a  post-effective  amendment  which  indicates that all securities
  offered herein have  been  sold  or  which  deregisters  all  securities  then  remaining
  unsold.<br></FONT></FONT></TD>
  </TR>
  </TABLE>
  <BR>
  
  <P ALIGN="LEFT"><FONT FACE="Times New Roman, Times, Serif"><FONT SIZE="2"><b>Item 4.
  Description of Securities.</b><br></FONT></FONT> </P>
  
  <P ALIGN="LEFT">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<FONT FACE="Times New Roman, Times, Serif"><FONT SIZE="2">Not
  applicable.<br></FONT></FONT> </P>
  
  <P ALIGN="LEFT"><FONT FACE="Times New Roman, Times, Serif"><FONT SIZE="2"><b>Item 5.
  Interests of Named Experts and Counsel.</b><br></FONT></FONT> </P>
  
  <P ALIGN="LEFT">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<FONT FACE="Times New Roman, Times, Serif"><FONT SIZE="2">Not
  applicable.<br></FONT></FONT> </P>
  
  <P ALIGN="LEFT"><FONT FACE="Times New Roman, Times, Serif"><FONT SIZE="2"><b>Item 6.
  Indemnification of Officers and Directors.</b><br></FONT></FONT> </P>
  
  <P ALIGN="LEFT">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<FONT FACE="Times New Roman, Times, Serif"><FONT SIZE="2">Section
  102(b)(7) of the  Delaware  General  Corporation  Law (the  &#147;DGCL&#148;)  permits a
  corporation  to  provide  in its  certificate  of  incorporation  that  a  director  of
  the  corporation  shall  not  be  personally  liable  to  the  corporation  or its
  stockholders  for  monetary  damages  for  breach of fiduciary  duty as a director,
  except for liability  (i) for any  breach of the  director&#146;s  duty of loyalty to the
  corporation  or its  stockholders,  (ii) for acts or omissions  not in good faith or
  which involve  intentional  misconduct or  a knowing  violation of law,  (iii) for
  unlawful  payments of  dividends  or  unlawful  stock  repurchases,  redemptions  or
  other  distributions,  or (iv) for any transaction  from which  the director derived an
  improper personal benefit.<br></FONT></FONT> </P>
  
  <P ALIGN="LEFT">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<FONT FACE="Times New Roman, Times, Serif"><FONT SIZE="2">Section
  145 of the DGCL provides  that a corporation  may  indemnify  any person,  including  a
  director or officer,  who  is, or is  threatened  to be made, a party to any  threatened,
  pending  or  completed  action,  suit or  proceeding,  whether  civil,  criminal,
  administrative or investigative (other than  an action by or in the right of such
  corporation),  by reason  of  fact  that  such  person  is or was a  director,  officer,
  employee  or agent of such  corporation,  or is or was serving  at the request of such
  corporation  as a  director,  officer,  employee or agent of another  corporation or
  other  enterprise  against  expenses  (including  attorney&#146;s  fees),  judgments,
  fines and amounts paid in settlement  actually and  reasonably  incurred by such person
  in connection  with such action,  suit  or  proceeding,  provided  such person acted good
  faith and in  a  manner  he or  she  reasonably  believed  to  be in or  not  opposed  to
  the  corporation&#146;s  best  interests  and,  with  respect  to  any  criminal  actions
  or  proceedings,  had  no  reasonable  cause  to  believe  that  his or her  conduct  was
  unlawful.  A  Delaware  corporation  may  provide  similar  indemnification  in an
  action  or suit by or in the  right of  the corporation,  except that no  indemnification
  is permitted  if such  person is  adjudged  to be liable to the  corporation  unless and
  to the extent  the Court of  Chancery  or the court  in which  such  action  or suit was
  brought  determines  that  such person is fairly and  reasonably  entitled to  indemnity.
  Where a director  or officer  is  successful  on the merits or  otherwise  in the
  defense  of any action  referred  to above,  the  corporation  must  indemnify  him  or
  her  against  the  expenses  which  such  director  or  officer  actually  and
  reasonably incurred.<br></FONT></FONT> </P>
  
  
  <hr width="100%" size="2">
  <P align="left" style="page-break-before:always">&nbsp;</P>
  
  
  
  
  <P ALIGN="LEFT">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<FONT FACE="Times New Roman, Times, Serif"><FONT SIZE="2">Article
  VIII  of  Genta&#146;s  restated  certificate  of  incorporation,  as  amended,  provides
  indemnification  of  directors  and  officers  of  Genta  to  the  fullest  extent
  permitted by the DGCL.<br></FONT></FONT> </P>
  
  <P ALIGN="LEFT">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<FONT FACE="Times New Roman, Times, Serif"><FONT SIZE="2">Genta
  maintains  liability  insurance  for each director  and  officer  for  certain  losses
  arising  from  claims  or  charges made  against  them while  acting in their  capacities
  as directors or officers of Genta.<br></FONT></FONT> </P>
  
  <P ALIGN="LEFT"><FONT FACE="Times New Roman, Times, Serif"><FONT SIZE="2"><b>Item 7.
  Exemption From Registration Claimed.</b><br></FONT></FONT> </P>
  
  <P ALIGN="LEFT">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<FONT FACE="Times New Roman, Times, Serif"><FONT SIZE="2">Not
  applicable.<br></FONT></FONT> </P>
  
  <P ALIGN="LEFT"><FONT FACE="Times New Roman, Times, Serif"><FONT SIZE="2"><b>Item 8.
  Exhibits.</b><br></FONT></FONT> </P>
  
  <P ALIGN="LEFT">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<FONT FACE="Times New Roman, Times, Serif"><FONT SIZE="2">The
  following Exhibits are filed as part of this  Registration Statement:<br></FONT></FONT> </P>
  
  
  
  <TABLE WIDTH="100%" CELLPADDING="0" CELLSPACING="0">
  <TR VALIGN="TOP">
       <TD ALIGN="right" WIDTH="9%"><FONT FACE="Times New Roman, Times, Serif"><FONT SIZE="2"><B>Exhibit&nbsp;<BR>
      <U>Number</U> </B></FONT></FONT></TD>
       <TD ALIGN="LEFT" WIDTH="3%"><font size="1" face="Times New Roman, Times, serif">&nbsp;</font></TD>
       <TD WIDTH="50%" align="center" valign="bottom"><FONT FACE="Times New Roman, Times, Serif"><FONT SIZE="2"><B><u>Description</u></B></FONT></FONT> </TD>
       <TD align="center" valign="bottom">&nbsp;</TD>
  </TR>
  </TABLE>
  <BR>
  
  
  <TABLE WIDTH="100%" CELLPADDING="0" CELLSPACING="0">
  <TR VALIGN="TOP">
       <TD ALIGN="RIGHT" WIDTH="9%"><FONT FACE="Times New Roman, Times, Serif"><FONT SIZE="2">5 </FONT></FONT></TD>
       <TD ALIGN="LEFT" WIDTH="3%">&nbsp;</TD>
       <TD><FONT FACE="Times New Roman, Times, Serif"><FONT SIZE="2"> Opinion
  of Davis Polk &amp; Wardwell</FONT></FONT> </TD>
  </TR>
  </TABLE>
  
  <TABLE WIDTH="100%" CELLPADDING="0" CELLSPACING="0">
  <TR VALIGN="TOP">
       <TD ALIGN="RIGHT" WIDTH="9%"><FONT FACE="Times New Roman, Times, Serif"><FONT SIZE="2">23.1 </FONT></FONT></TD>
       <TD ALIGN="LEFT" WIDTH="3%">&nbsp;</TD>
       <TD><FONT FACE="Times New Roman, Times, Serif"><FONT SIZE="2"> Consent
  of Deloitte &amp; Touche LLP</FONT></FONT> </TD>
  </TR>
  </TABLE>
  
  <TABLE WIDTH="100%" CELLPADDING="0" CELLSPACING="0">
  <TR VALIGN="TOP">
       <TD ALIGN="RIGHT" WIDTH="9%"><FONT FACE="Times New Roman, Times, Serif"><FONT SIZE="2">23.2 </FONT></FONT></TD>
       <TD ALIGN="LEFT" WIDTH="3%">&nbsp;</TD>
       <TD><FONT FACE="Times New Roman, Times, Serif"><FONT SIZE="2"> Consent
  of Davis Polk &amp; Wardwell (included in Exhibit 5)</FONT></FONT> </TD>
  </TR>
  </TABLE>
  
  <TABLE WIDTH="100%" CELLPADDING="0" CELLSPACING="0">
  <TR VALIGN="TOP">
       <TD ALIGN="RIGHT" WIDTH="9%"><FONT FACE="Times New Roman, Times, Serif"><FONT SIZE="2">24 </FONT></FONT></TD>
       <TD ALIGN="LEFT" WIDTH="3%">&nbsp;</TD>
       <TD><FONT FACE="Times New Roman, Times, Serif"><FONT SIZE="2"> Power
  of Attorney (included on signature page)</FONT></FONT> </TD>
  </TR>
  </TABLE>
  <BR>
  
  
  <P ALIGN="LEFT"><FONT FACE="Times New Roman, Times, Serif"><FONT SIZE="2"><b>Item 9.
  Undertakings.</b><br></FONT></FONT> </P>
  
  <P ALIGN="LEFT">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<FONT FACE="Times New Roman, Times, Serif"><FONT SIZE="2">The
  undersigned registrant hereby undertakes:<br></FONT></FONT> </P>
  <table width="100%"  border="0" cellspacing="0" cellpadding="0">
    <tr valign="top">
      <td width="3%"><font size="2" face="Times New Roman, Times, serif">(a)</font></td>
      <td width="3%">
      <p><font face="Times New Roman, Times, serif"><font size="2"></font></font></p></td>
      <td width="3%"><font size="2" face="Times New Roman, Times, serif">(1)</font></td>
      <td width="3%"><font size="2" face="Times New Roman, Times, serif">&nbsp;</font></td>
      <td><font size="2" face="Times New Roman, Times, serif">To
  file,  during  any  period in which  offers or  sales are  being  made of  securities
  registered  hereby,  a  post-  effective  amendment  to  this  registration statement:</font></td>
    </tr>
    <tr valign="top">
      <td><font size="2" face="Times New Roman, Times, serif">&nbsp;</font></td>
      <td><font size="2" face="Times New Roman, Times, serif">&nbsp;</font></td>
      <td><font size="2" face="Times New Roman, Times, serif">&nbsp;</font></td>
      <td><font size="2" face="Times New Roman, Times, serif">&nbsp;</font></td>
      <td><font size="2" face="Times New Roman, Times, serif">&nbsp;</font></td>
    </tr>
    <tr valign="top">
      <td><font size="2" face="Times New Roman, Times, serif">&nbsp;</font></td>
      <td><font size="2" face="Times New Roman, Times, serif">&nbsp;</font></td>
      <td><font size="2" face="Times New Roman, Times, serif">&nbsp;</font></td>
      <td><font size="2" face="Times New Roman, Times, serif">&nbsp;</font></td>
      <td><font size="2" face="Times New Roman, Times, serif">(i)
  To include  any  material  information  with  respect  to  the  plan  of  distribution
  not  previously  disclosed  in  the  registration  statement  or  any  material  change
  to  such  information in the registration statement.</font></td>
    </tr>
    <tr valign="top">
      <td><font size="2" face="Times New Roman, Times, serif">&nbsp;</font></td>
      <td><font size="2" face="Times New Roman, Times, serif">&nbsp;</font></td>
      <td><font size="2" face="Times New Roman, Times, serif">&nbsp;</font></td>
      <td><font size="2" face="Times New Roman, Times, serif">&nbsp;</font></td>
      <td><font size="2" face="Times New Roman, Times, serif">&nbsp;</font></td>
    </tr>
    <tr valign="top">
      <td><font size="2" face="Times New Roman, Times, serif">&nbsp;</font></td>
      <td><font size="2" face="Times New Roman, Times, serif">&nbsp;</font></td>
      <td><font size="2" face="Times New Roman, Times, serif">(2)</font></td>
      <td><font size="2" face="Times New Roman, Times, serif">&nbsp;</font></td>
      <td><font size="2" face="Times New Roman, Times, serif">That,
  for  the  purpose  of  determining  any  liability  under  the  Securities  Act of  1933,
  each  such  post-effective  amendment  shall  be  deemed  to  be  a  new  registration
  statement  relating to the securities offered therein,  and  the  offering  of such
  securities  at that time  shall be  deemed  to be the  initial  bona  fide  offering
  thereof.</font></td>
    </tr>
    <tr valign="top">
      <td><font size="2" face="Times New Roman, Times, serif">&nbsp;</font></td>
      <td><font size="2" face="Times New Roman, Times, serif">&nbsp;</font></td>
      <td><font size="2" face="Times New Roman, Times, serif">&nbsp;</font></td>
      <td><font size="2" face="Times New Roman, Times, serif">&nbsp;</font></td>
      <td><font size="2" face="Times New Roman, Times, serif">&nbsp;</font></td>
    </tr>
    <tr valign="top">
      <td><font size="2" face="Times New Roman, Times, serif">&nbsp;</font></td>
      <td><font size="2" face="Times New Roman, Times, serif">&nbsp;</font></td>
      <td><font size="2" face="Times New Roman, Times, serif">(3)</font></td>
      <td><font size="2" face="Times New Roman, Times, serif">&nbsp;</font></td>
      <td><font size="2" face="Times New Roman, Times, serif">To
  remove  from  registration  by  means  of a  post-effective  amendment any of the
  securities  being  registered  which  remain  unsold  at the  termination of the offering.</font></td>
    </tr>
  </table>
  <BR>
  
  
  
  
  
  
  
  
  
  
  <TABLE WIDTH="100%" CELLPADDING="0" CELLSPACING="0">
  <TR VALIGN="TOP">
       <TD ALIGN="LEFT" WIDTH="3%" nowrap><FONT FACE="Times New Roman, Times, Serif"><FONT SIZE="2">
  (b) </FONT></FONT></TD>
       <TD ALIGN="LEFT" WIDTH="3%">&nbsp;</TD>
       <TD WIDTH="94%"><FONT FACE="Times New Roman, Times, Serif"><FONT SIZE="2">
   That,
  for the  purpose  of  determining  any  liability  under the  Securities  Act of 1933,
  each  filing of the  registrant&#146;s  annual  report  pursuant to Section  13(a)  or
  15(d) of the  Securities  Exchange  Act of 1934  that  is  incorporated  by  reference
  in  the  registration  statement  shall  be  deemed  to be a  new  registration
  statement  relating to the securities  offered  therein,  and the offering of such
  securities  at that time shall  be deemed to be initial bona fide offering thereof.<br></FONT></FONT></TD>
  </TR>
  </TABLE>
  <BR>
  
  <TABLE WIDTH="100%" CELLPADDING="0" CELLSPACING="0">
  <TR VALIGN="TOP">
       <TD ALIGN="LEFT" WIDTH="3%" nowrap><FONT FACE="Times New Roman, Times, Serif"><FONT SIZE="2">
  (c) </FONT></FONT></TD>
       <TD ALIGN="LEFT" WIDTH="3%">&nbsp;</TD>
       <TD WIDTH="94%"><FONT FACE="Times New Roman, Times, Serif"><FONT SIZE="2">
   Insofar
  as  indemnification  for  liabilities  arising  under the  Securities  Act of 1933 may be
  permitted  to  directors,  officers  and  controlling  persons  of  the  registrant
  pursuant  to the  provisions  referenced  in  Item 6 of this  Registration  Statement,
  or  otherwise,  the  registrant  has been advised that in the opinion of  the  Securities
  and  Exchange  Commission  such  indemnification  is against  public  policy as expressed
  in the  Act  and is,  therefore,  unenforceable.  In the  event  that a claim  for
  indemnification  against  such  liabilities  (other than the  payment by the  registrant
  of expenses  incurred or paid by a director,  officer or  controlling  person of the
  registrant in the successful  defense of any action,  suit or  proceeding) is asserted
  by such  director,  officer  or  controlling  person  in  connection  with  the
  securities  being  registered  hereunder,  the registrant  will,  unless in the opinion
  of  its  counsel  the  matter  has  been  settled  by  controlling  precedent,  submit
  to  a  court  of  appropriate  jurisdiction  the  question of whether such
  indemnification  by  it  is  against  public  policy  as  expressed  in the Act and will
  be  governed by the final  adjudication of such issue.<br></FONT></FONT></TD>
  </TR>
  </TABLE>
  <BR>
  
  
  <hr width="100%" size="2">
  <P align="left" style="page-break-before:always">&nbsp;</P>
  
  
  
  
  <P ALIGN="LEFT"><FONT FACE="Times New Roman, Times, Serif"><FONT SIZE="2"><b>SIGNATURES</b><br></FONT></FONT> </P>
  
  <P ALIGN="LEFT">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<FONT FACE="Times New Roman, Times, Serif"><FONT SIZE="2">Pursuant
  to the  requirements  of the  Securities  Act of  1933,  the  registrant  certifies  that
  it  has  reasonable  grounds to believe that it meets all of the  requirements  for
  filing  on Form  S-8 and has  duly  caused  this  Registration  Statement  to be  signed
  on its  behalf  by the  undersigned,  thereunto duly  authorized,  in the City of
  Berkeley  Heights,  State of New Jersey, on the 15th day of September, 2005.<br></FONT></FONT> </P>
  
  
  
  <table width="100%"  border="0" cellspacing="0" cellpadding="0">
    <tr>
      <td colspan="3"><font size="2" face="Times New Roman, Times, serif">GENTA INCORPORATED</font></td>
    </tr>
    <tr>
      <td colspan="3"><font size="2" face="Times New Roman, Times, serif">(Registrant)<br>
      </font></td>
    </tr>
    <tr>
      <td width="5%"><font size="2" face="Times New Roman, Times, serif">By:</font></td>
      <td colspan="2"><font size="2" face="Times New Roman, Times, serif"><u>/s/ William P. Keane</u></font></td>
    </tr>
    <tr>
      <td><font size="2" face="Times New Roman, Times, serif">&nbsp;</font></td>
      <td width="5%"><font size="2" face="Times New Roman, Times, serif">Name:</font></td>
      <td><font size="2" face="Times New Roman, Times, serif">William P. Keane</font></td>
    </tr>
    <tr>
      <td><font size="2" face="Times New Roman, Times, serif">&nbsp;</font></td>
      <td valign="top"><font size="2" face="Times New Roman, Times, serif">Title:</font></td>
      <td valign="top"><font size="2" face="Times New Roman, Times, serif">Senior Vice President, Chief Financial Officer
  and Corporate Secretary </font></td>
    </tr>
  
  </table>
  
  
  
  
  
  
  <P ALIGN="LEFT">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<FONT FACE="Times New Roman, Times, Serif"><FONT SIZE="2">KNOW
  ALL MEN BY THESE  PRESENTS,  that each person  whose  signature  appears below
  constitutes and appoints  Raymond P.  Warrell,  Jr.,  M.D.  and William P. Keane,  and
  each of them,  his or her  true  and  lawful  attorneys-in-fact  and  agents,  with full
  power of substitution  and  resubstitution,  for him  or her and in his or her  name,
  place and  stead,  in any and  all  capacities,  to sign  any and all  amendments
  (including  post-effective  amendments)  to  this  registration  statement  and any and
  all  amendments  to this  Registration  Statement,  and to file the  same,  with  all
  exhibits  thereto,  and all  other documents in connection  therewith,  with the
  Securities  and  Exchange  Commission,  granting  unto  each  said  attorney-in-fact  and
  agents  full power and  authority  to do  and  perform  each and every act in person,
  hereby  ratifying  and confirming all that said  attorneys-in-fact  and agents or  either
  of  them  or  their  or  his  or  her  substitute  or  substitutes  may  lawfully  do or
  cause  to be done by  virtue  hereof.<br></FONT></FONT> </P>
  
  <P ALIGN="LEFT">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<FONT FACE="Times New Roman, Times, Serif"><FONT SIZE="2">Pursuant
  to the  requirements  of the  Securities  Act of  1933,  as  amended,  this  Registration
  Statement  has  been  signed by the following  persons in the  capacities and on the
  dates indicated.<br></FONT></FONT> </P>
  
  
  
  
  
  <table width="100%"  border="0" cellspacing="0" cellpadding="0">
    <tr>
      <td><b><font size="2" face="Times New Roman, Times, serif">Signature</font></b></td>
      <td align="center"><b><font size="2" face="Times New Roman, Times, serif">Title
        </font></b></td>
      <td align="center"><b><font size="2" face="Times New Roman, Times, serif">Date</font></b></td>
    </tr>
    <tr>
      <td>&nbsp;</td>
      <td align="center">&nbsp;</td>
      <td align="center">&nbsp;</td>
    </tr>
    <tr>
      <td><font size="2" face="Times New Roman, Times, serif"><u>/s/ Raymond P.
        Warrell, Jr., M.D.</u> </font></td>
      <td align="center"><font size="2" face="Times New Roman, Times, serif">Chairman
        of the Board of Directors and Chief Executive</font></td>
      <td align="center"><font size="2" face="Times New Roman, Times, serif">&nbsp;</font></td>
    </tr>
    <tr>
      <td><font size="2" face="Times New Roman, Times, serif">Raymond P. Warrell,
        Jr., M.D.</font></td>
      <td align="center"><font size="2" face="Times New Roman, Times, serif">Officer
        (Principal Executive Officer)</font></td>
      <td align="center"><font size="2" face="Times New Roman, Times, serif">September
        15, 2005</font></td>
    </tr>
    <tr>
      <td><font size="2" face="Times New Roman, Times, serif">&nbsp;</font></td>
      <td align="center"><font size="2" face="Times New Roman, Times, serif">&nbsp;</font></td>
      <td align="center"><font size="2" face="Times New Roman, Times, serif">&nbsp;</font></td>
    </tr>
    <tr>
      <td><font size="2" face="Times New Roman, Times, serif"><u>/s/ William P.
        Keane</u></font></td>
      <td align="center"><font size="2" face="Times New Roman, Times, serif">Senior
        Vice President, Chief Financial Officer and Corporate</font></td>
      <td align="center"><font size="2" face="Times New Roman, Times, serif">&nbsp;</font></td>
    </tr>
    <tr>
      <td><font size="2" face="Times New Roman, Times, serif">William P. Keane</font></td>
      <td align="center"><font size="2" face="Times New Roman, Times, serif">Secretary
        (Principal Accounting Officer)</font></td>
      <td align="center"><font size="2" face="Times New Roman, Times, serif">September
        15, 2005</font></td>
    </tr>
    <tr>
      <td><font size="2" face="Times New Roman, Times, serif">&nbsp;</font></td>
      <td align="center"><font size="2" face="Times New Roman, Times, serif">&nbsp;</font></td>
      <td align="center"><font size="2" face="Times New Roman, Times, serif">&nbsp;</font></td>
    </tr>
    <tr>
      <td><u><font size="2" face="Times New Roman, Times, serif">/s/ Martin Driscoll</font></u></td>
      <td align="center"><font size="2" face="Times New Roman, Times, serif">&nbsp;</font></td>
      <td align="center"><font size="2" face="Times New Roman, Times, serif">&nbsp;</font></td>
    </tr>
    <tr>
      <td><font size="2" face="Times New Roman, Times, serif">Martin Driscoll</font></td>
      <td align="center"><font size="2" face="Times New Roman, Times, serif">Director</font></td>
      <td align="center"><font size="2" face="Times New Roman, Times, serif">September
        15, 2005</font></td>
    </tr>
    <tr>
      <td>&nbsp;</td>
      <td align="center">&nbsp;</td>
      <td align="center">&nbsp;</td>
    </tr>
    <tr>
      <td><font size="2" face="Times New Roman, Times, serif"><u>/s/ Jerome E. Groopman,
        M.D.</u></font></td>
      <td align="center"><font size="2" face="Times New Roman, Times, serif">&nbsp;</font></td>
      <td align="center"><font size="2" face="Times New Roman, Times, serif">&nbsp;</font></td>
    </tr>
    <tr>
      <td><font size="2" face="Times New Roman, Times, serif">Jerome E. Groopman,
        M.D.</font></td>
      <td align="center"><font size="2" face="Times New Roman, Times, serif"> Director
        </font></td>
      <td align="center"><font size="2" face="Times New Roman, Times, serif"> September
        15, 2005</font></td>
    </tr>
    <tr>
      <td><font size="2" face="Times New Roman, Times, serif">&nbsp;</font></td>
      <td align="center"><font size="2" face="Times New Roman, Times, serif">&nbsp;</font></td>
      <td align="center"><font size="2" face="Times New Roman, Times, serif">&nbsp;</font></td>
    </tr>
    <tr>
      <td><font size="2" face="Times New Roman, Times, serif"><u>/s/ Betsy McCaughey,
        Ph.D.</u></font></td>
      <td align="center"><font size="2" face="Times New Roman, Times, serif">&nbsp;</font></td>
      <td align="center"><font size="2" face="Times New Roman, Times, serif">&nbsp;</font></td>
    </tr>
    <tr>
      <td><font size="2" face="Times New Roman, Times, serif">Betsy McCaughey, Ph.D.</font></td>
      <td align="center"><font size="2" face="Times New Roman, Times, serif"> Director
        </font></td>
      <td align="center"><font size="2" face="Times New Roman, Times, serif"> September
        15, 2005</font></td>
    </tr>
    <tr>
      <td><font size="2" face="Times New Roman, Times, serif">&nbsp;</font></td>
      <td align="center"><font size="2" face="Times New Roman, Times, serif">&nbsp;</font></td>
      <td align="center"><font size="2" face="Times New Roman, Times, serif">&nbsp;</font></td>
    </tr>
    <tr>
      <td><u><font size="2" face="Times New Roman, Times, serif">/s/ Christopher Parios</font></u></td>
      <td align="center"><font size="2" face="Times New Roman, Times, serif">&nbsp;</font></td>
      <td align="center"><font size="2" face="Times New Roman, Times, serif">&nbsp;</font></td>
    </tr>
    <tr>
      <td><font size="2" face="Times New Roman, Times, serif">Christopher Parios</font></td>
      <td align="center"><font size="2" face="Times New Roman, Times, serif">Director</font></td>
      <td align="center"><font size="2" face="Times New Roman, Times, serif">September
        15, 2005</font></td>
    </tr>
    <tr>
      <td>&nbsp;</td>
      <td align="center">&nbsp;</td>
      <td align="center">&nbsp;</td>
    </tr>
    <tr>
      <td><font size="2" face="Times New Roman, Times, serif"><u>/s/ Daniel D. Von
        Hoff, M.D.</u></font></td>
      <td align="center"><font size="2" face="Times New Roman, Times, serif">&nbsp;</font></td>
      <td align="center"><font size="2" face="Times New Roman, Times, serif">&nbsp;</font></td>
    </tr>
    <tr>
      <td><font size="2" face="Times New Roman, Times, serif">Daniel D. Von Hoff,
        M.D.</font></td>
      <td align="center"><font size="2" face="Times New Roman, Times, serif"> Director
        </font></td>
      <td align="center"><font size="2" face="Times New Roman, Times, serif"> September
        15, 2005</font></td>
    </tr>
    <tr>
      <td><font size="2" face="Times New Roman, Times, serif">&nbsp;</font></td>
      <td align="center"><font size="2" face="Times New Roman, Times, serif">&nbsp;</font></td>
      <td align="center"><font size="2" face="Times New Roman, Times, serif">&nbsp;</font></td>
    </tr>
    <tr>
      <td><font size="2" face="Times New Roman, Times, serif"><u>/s/ Harlan J. Wakoff</u></font></td>
      <td align="center"><font size="2" face="Times New Roman, Times, serif">&nbsp;</font></td>
      <td align="center"><font size="2" face="Times New Roman, Times, serif">&nbsp;</font></td>
    </tr>
    <tr>
      <td><font size="2" face="Times New Roman, Times, serif">Harlan J. Wakoff</font></td>
      <td align="center"><font size="2" face="Times New Roman, Times, serif"> Director
        </font></td>
      <td align="center"><font size="2" face="Times New Roman, Times, serif"> September
        15, 2005</font></td>
    </tr>
    <tr>
      <td><font size="2" face="Times New Roman, Times, serif">&nbsp;</font></td>
      <td align="center"><font size="2" face="Times New Roman, Times, serif">&nbsp;</font></td>
      <td align="center"><font size="2" face="Times New Roman, Times, serif">&nbsp;</font></td>
    </tr>
    <tr>
      <td><font size="2" face="Times New Roman, Times, serif"><u>/s/ Douglas G.
        Watson</u></font></td>
      <td align="center"><font size="2" face="Times New Roman, Times, serif">&nbsp;</font></td>
      <td align="center"><font size="2" face="Times New Roman, Times, serif">&nbsp;</font></td>
    </tr>
    <tr>
      <td><font size="2" face="Times New Roman, Times, serif">Douglas G. Watson</font></td>
      <td align="center"><font size="2" face="Times New Roman, Times, serif"> Director
        </font></td>
      <td align="center"><font size="2" face="Times New Roman, Times, serif"> September
        15, 2005</font></td>
    </tr>
  </table>
  <BR>
  
  <hr width="100%" size="2">
  <P align="left" style="page-break-before:always">&nbsp;</P>
  
  
  
  
  <P ALIGN="CENTER"><FONT FACE="Times New Roman, Times, Serif"><FONT SIZE="2"><B>EXHIBIT  INDEX</B></FONT></FONT> </P>
  
  <TABLE WIDTH="100%" CELLPADDING="0" CELLSPACING="0">
    <TR VALIGN="bottom">
      <TD WIDTH="20%" ALIGN="left"><FONT FACE="Times New Roman, Times, Serif"><FONT SIZE="2"><B>&nbsp;Exhibit<BR>
      <U>Number </U></B></FONT></FONT></TD>
      <TD WIDTH="3%" ALIGN="LEFT"><font size="2" face="Times New Roman, Times, serif">&nbsp;</font></TD>
      <TD align="center">
  <P ALIGN="CENTER"><FONT size="2" FACE="Times New Roman, Times, serif"> <B><u>Description</u></B>
          </FONT> </P></TD>
      <TD WIDTH="20%" align="center"><font size="2" face="Times New Roman, Times, serif"><B>Sequentially <BR>
        Numbered <BR>
        <u>Page</u></B>
      </font></TD>
    </TR>
  </TABLE>
  <br>
  
  
  
  <TABLE WIDTH="100%" CELLPADDING="0" CELLSPACING="0">
    <TR VALIGN="TOP">
      <TD ALIGN="left" WIDTH="20%"><FONT FACE="Times New Roman, Times, Serif"><FONT SIZE="2">5 </FONT></FONT></TD>
      <TD ALIGN="LEFT" WIDTH="3%">&nbsp;</TD>
      <TD>
  <P ALIGN="LEFT"><FONT FACE="Times New Roman, Times, Serif"><FONT SIZE="2"> Opinion
  of Davis Polk &amp; Wardwell<br>
          </FONT></FONT> </P></TD>
      <TD WIDTH="10%">&nbsp;</TD>
    </TR>
  </TABLE>
  
  <TABLE WIDTH="100%" CELLPADDING="0" CELLSPACING="0">
    <TR VALIGN="TOP">
      <TD ALIGN="left" WIDTH="20%"><FONT FACE="Times New Roman, Times, Serif"><FONT SIZE="2">23.1 </FONT></FONT></TD>
      <TD ALIGN="LEFT" WIDTH="3%">&nbsp;</TD>
      <TD>
  <P ALIGN="LEFT"><FONT FACE="Times New Roman, Times, Serif"><FONT SIZE="2"> Consent
  of Deloitte &amp; Touche LLP<br>
          </FONT></FONT> </P></TD>
      <TD WIDTH="10%">&nbsp;</TD>
    </TR>
  </TABLE>
  
  <TABLE WIDTH="100%" CELLPADDING="0" CELLSPACING="0">
    <TR VALIGN="TOP">
      <TD ALIGN="left" WIDTH="20%"><FONT FACE="Times New Roman, Times, Serif"><FONT SIZE="2">23.2 </FONT></FONT></TD>
      <TD ALIGN="LEFT" WIDTH="3%">&nbsp;</TD>
      <TD>
  <P ALIGN="LEFT"><FONT FACE="Times New Roman, Times, Serif"><FONT SIZE="2"> Consent
  of Davis Polk &amp; Wardwell (included in Exhibit 5)<br>
          </FONT></FONT> </P></TD>
      <TD WIDTH="10%">&nbsp;</TD>
    </TR>
  </TABLE>
  
  <TABLE WIDTH="100%" CELLPADDING="0" CELLSPACING="0">
    <TR VALIGN="TOP">
      <TD ALIGN="left" WIDTH="20%"><FONT FACE="Times New Roman, Times, Serif"><FONT SIZE="2">24 </FONT></FONT></TD>
      <TD ALIGN="LEFT" WIDTH="3%">&nbsp;</TD>
      <TD>
  <P ALIGN="LEFT"><FONT FACE="Times New Roman, Times, Serif"><FONT SIZE="2"> Power
  of Attorney (included on signature page)<br>
          </FONT></FONT> </P></TD>
      <TD WIDTH="10%">&nbsp;</TD>
    </TR>
  </TABLE>
  <br>
  
  <hr width="100%" size="2">
  
  </body>
  </html>
metadata_documents: [{"type": "S-8", "sequence": "1", "filename": "e500974_s8-genta.htm", "description": "FORM S-8", "secsgml_size_bytes": 39780}]
metadata_filer: {"company-data": {"conformed-name": "GENTA INC DE/", "cik": "0000880643", "assigned-sic": "2836", "irs-number": "330326866", "state-of-incorporation": "DE", "fiscal-year-end": "1231"}, "filing-values": {"form-type": "S-8", "act": "33", "file-number": "333-128381", "film-number": "051089205"}, "business-address": {"street1": "TWO CONNELL DRIVE", "street2": "..", "city": "BERKELEY HEIGHTS", "state": "NJ", "zip": "07922", "phone": "(908) 286-9800"}, "mail-address": {"street1": "TWO CONNELL DRIVE", "street2": "..", "city": "BERKELEY HEIGHTS", "state": "NJ", "zip": "07922"}}
text: Untitled Document
  As filed with
  the Securities and Exchange Commission on September 16, 2005
  Registration No. 333-_
  ______
  UNITED STATES
  SECURITIES AND EXCHANGE COMMISSION
  Washington, D.C. 20549
  FORM S-8
  REGISTRATION
  STATEMENT
  UNDER
  THE SECURITIES ACT OF 1933
  GENTA
  INCORPORATED
  (Exact Name of Registrant as Specified in Its Charter)
  Delaware
  2836
  33-0326866
  (State or other
        jurisdiction of
        incorporation or organization)
  (Primary Standard Industrial Classification
  Code Number)
  (I.R.S. Employer
  
        Identification Number)
  Two Connell Drive
  Berkeley Heights, NJ 07922
  (908) 286-9800
  (Address, Including Zip Code, and Telephone Number, Including Area Code, of Registrant's Principal Executive Offices)
  GENTA
  INCORPORATED 1998 NON-EMPLOYEE DIRECTORS' STOCK OPTION PLAN
  (Full title of the plan)
  William P.
  Keane
  Senior Vice President, Chief Financial Officer
  and Corporate Secretary
  Genta
  Incorporated
  Two Connell Drive
  Berkeley Heights, NJ 07922
  (908) 286-9800
  (Name, Address, Including Zip
           Code, and Telephone Number, Including Area Code, of
           Agent For Service)
  Copy to:
  Richard A. Drucker
  Davis Polk & Wardwell
  450 Lexington Avenue
  New York, New York
  10017 (212) 450-4000
  CALCULATION
  OF REGISTRATION FEE
  Title Of Each Class
  Of Securities To Be Registered
  Amount To Be
  Registered (1)
  Proposed
  Maximum
  Offering Price
  Per Unit (2)
  Proposed
  Maximum
  Aggregate
  Offering Price (2)
  Amount Of
  Registration Fee
  Common Stock, par value $.001 per share
  500,000
  $
  1.21
  $
  605,000
  $
  71.21
  (1)
  Pursuant
  to Rule 416 under the Securities Act of 1933,  this  Registration  Statement also covers
  such  additional  shares as may  hereinafter be offered or issued to prevent dilution
  resulting from stock splits,  stock dividends,  stock  recapitalizations  or  certain
  other capital adjustments.
  (2)
  Estimated
  solely for the purpose of computing the amount of the  registration  fee pursuant to Rule
  457(c) under the  Securities  Act of 1933 based on the average of the high and low prices
  of the Common  Stock on the Nasdaq  National  Market on  September 15,  2005.
  PART II
  INFORMATION
  REQUIRED IN THE REGISTRATION STATEMENT
  Item 3.
  Incorporation of Documents by Reference.
  The
  following  documents  filed  by  Genta  Incorporated  ("Genta")  with  the
  Securities  and  Exchange  Commission  pursuant to the  Securities  Exchange Act of 1934,
  as amended  (the "Exchange Act"),  are  incorporated in this  Registration
  Statement by reference:
  1.
  Our
  Annual Report on Form 10-K for the fiscal year  ended December 31, 2004.
  2.
  Our
  Quarterly Reports on Form 10-Q and 10-Q/A for the  quarterly periods ended March 31 and
  June 30, 2005.
  3.
  Our
  Current Reports on Form 8-K filed on January 11,  March 15, April 19, April 28, May 5,
  May 10, May 13, May  16, May 17, June 13, June 23, June 30, 2005 and August  8, 2005.
  4.
  The
  description of our shares of common stock contained  in the Registration  Statement on
  Form S-3 that was filed  on April 2, 2004 and any subsequent  amendments  thereto,  or in
  a  Registration  Statement  on Form  8-A,  updating  such description.
  5.
  All
  other  documents  filed by us  pursuant  to Sections  13(a),  13(c),  14  and  15(d)  of
  the  Exchange  Act  subsequent  to the  date of this  Registration  Statement  and  prior
  to the  filing of a  post-effective  amendment  which  indicates that all securities
  offered herein have  been  sold  or  which  deregisters  all  securities  then  remaining
  unsold.
  Item 4.
  Description of Securities.
  Not
  applicable.
  Item 5.
  Interests of Named Experts and Counsel.
  Not
  applicable.
  Item 6.
  Indemnification of Officers and Directors.
  Section
  102(b)(7) of the  Delaware  General  Corporation  Law (the  "DGCL")  permits a
  corporation  to  provide  in its  certificate  of  incorporation  that  a  director  of
  the  corporation  shall  not  be  personally  liable  to  the  corporation  or its
  stockholders  for  monetary  damages  for  breach of fiduciary  duty as a director,
  except for liability  (i) for any  breach of the  director's  duty of loyalty to the
  corporation  or its  stockholders,  (ii) for acts or omissions  not in good faith or
  which involve  intentional  misconduct or  a knowing  violation of law,  (iii) for
  unlawful  payments of  dividends  or  unlawful  stock  repurchases,  redemptions  or
  other  distributions,  or (iv) for any transaction  from which  the director derived an
  improper personal benefit.
  Section
  145 of the DGCL provides  that a corporation  may  indemnify  any person,  including  a
  director or officer,  who  is, or is  threatened  to be made, a party to any  threatened,
  pending  or  completed  action,  suit or  proceeding,  whether  civil,  criminal,
  administrative or investigative (other than  an action by or in the right of such
  corporation),  by reason  of  fact  that  such  person  is or was a  director,  officer,
  employee  or agent of such  corporation,  or is or was serving  at the request of such
  corporation  as a  director,  officer,  employee or agent of another  corporation or
  other  enterprise  against  expenses  (including  attorney's  fees),  judgments,
  fines and amounts paid in settlement  actually and  reasonably  incurred by such person
  in connection  with such action,  suit  or  proceeding,  provided  such person acted good
  faith and in  a  manner  he or  she  reasonably  believed  to  be in or  not  opposed  to
  the  corporation's  best  interests  and,  with  respect  to  any  criminal  actions
  or  proceedings,  had  no  reasonable  cause  to  believe  that  his or her  conduct  was
  unlawful.  A  Delaware  corporation  may  provide  similar  indemnification  in an
  action  or suit by or in the  right of  the corporation,  except that no  indemnification
  is permitted  if such  person is  adjudged  to be liable to the  corporation  unless and
  to the extent  the Court of  Chancery  or the court  in which  such  action  or suit was
  brought  determines  that  such person is fairly and  reasonably  entitled to  indemnity.
  Where a director  or officer  is  successful  on the merits or  otherwise  in the
  defense  of any action  referred  to above,  the  corporation  must  indemnify  him  or
  her  against  the  expenses  which  such  director  or  officer  actually  and
  reasonably incurred.
  Article
  VIII  of  Genta's  restated  certificate  of  incorporation,  as  amended,  provides
  indemnification  of  directors  and  officers  of  Genta  to  the  fullest  extent
  permitted by the DGCL.
  Genta
  maintains  liability  insurance  for each director  and  officer  for  certain  losses
  arising  from  claims  or  charges made  against  them while  acting in their  capacities
  as directors or officers of Genta.
  Item 7.
  Exemption From Registration Claimed.
  Not
  applicable.
  Item 8.
  Exhibits.
  The
  following Exhibits are filed as part of this  Registration Statement:
  Exhibit
  Number
  Description
  5
  Opinion
  of Davis Polk & Wardwell
  23.1
  Consent
  of Deloitte & Touche LLP
  23.2
  Consent
  of Davis Polk & Wardwell (included in Exhibit 5)
  24
  Power
  of Attorney (included on signature page)
  Item 9.
  Undertakings.
  The
  undersigned registrant hereby undertakes:
  (a)
  (1)
  To
  file,  during  any  period in which  offers or  sales are  being  made of  securities
  registered  hereby,  a  post-  effective  amendment  to  this  registration statement:
  (i)
  To include  any  material  information  with  respect  to  the  plan  of  distribution
  not  previously  disclosed  in  the  registration  statement  or  any  material  change
  to  such  information in the registration statement.
  (2)
  That,
  for  the  purpose  of  determining  any  liability  under  the  Securities  Act of  1933,
  each  such  post-effective  amendment  shall  be  deemed  to  be  a  new  registration
  statement  relating to the securities offered therein,  and  the  offering  of such
  securities  at that time  shall be  deemed  to be the  initial  bona  fide  offering
  thereof.
  (3)
  To
  remove  from  registration  by  means  of a  post-effective  amendment any of the
  securities  being  registered  which  remain  unsold  at the  termination of the offering.
  (b)
  That,
  for the  purpose  of  determining  any  liability  under the  Securities  Act of 1933,
  each  filing of the  registrant's  annual  report  pursuant to Section  13(a)  or
  15(d) of the  Securities  Exchange  Act of 1934  that  is  incorporated  by  reference
  in  the  registration  statement  shall  be  deemed  to be a  new  registration
  statement  relating to the securities  offered  therein,  and the offering of such
  securities  at that time shall  be deemed to be initial bona fide offering thereof.
  (c)
  Insofar
  as  indemnification  for  liabilities  arising  under the  Securities  Act of 1933 may be
  permitted  to  directors,  officers  and  controlling  persons  of  the  registrant
  pursuant  to the  provisions  referenced  in  Item 6 of this  Registration  Statement,
  or  otherwise,  the  registrant  has been advised that in the opinion of  the  Securities
  and  Exchange  Commission  such  indemnification  is against  public  policy as expressed
  in the  Act  and is,  therefore,  unenforceable.  In the  event  that a claim  for
  indemnification  against  such  liabilities  (other than the  payment by the  registrant
  of expenses  incurred or paid by a director,  officer or  controlling  person of the
  registrant in the successful  defense of any action,  suit or  proceeding) is asserted
  by such  director,  officer  or  controlling  person  in  connection  with  the
  securities  being  registered  hereunder,  the registrant  will,  unless in the opinion
  of  its  counsel  the  matter  has  been  settled  by  controlling  precedent,  submit
  to  a  court  of  appropriate  jurisdiction  the  question of whether such
  indemnification  by  it  is  against  public  policy  as  expressed  in the Act and will
  be  governed by the final  adjudication of such issue.
  SIGNATURES
  Pursuant
  to the  requirements  of the  Securities  Act of  1933,  the  registrant  certifies  that
  it  has  reasonable  grounds to believe that it meets all of the  requirements  for
  filing  on Form  S-8 and has  duly  caused  this  Registration  Statement  to be  signed
  on its  behalf  by the  undersigned,  thereunto duly  authorized,  in the City of
  Berkeley  Heights,  State of New Jersey, on the 15th day of September, 2005.
  GENTA INCORPORATED
  (Registrant)
  By:
  /s/ William P. Keane
  Name:
  William P. Keane
  Title:
  Senior Vice President, Chief Financial Officer
  and Corporate Secretary
  KNOW
  ALL MEN BY THESE  PRESENTS,  that each person  whose  signature  appears below
  constitutes and appoints  Raymond P.  Warrell,  Jr.,  M.D.  and William P. Keane,  and
  each of them,  his or her  true  and  lawful  attorneys-in-fact  and  agents,  with full
  power of substitution  and  resubstitution,  for him  or her and in his or her  name,
  place and  stead,  in any and  all  capacities,  to sign  any and all  amendments
  (including  post-effective  amendments)  to  this  registration  statement  and any and
  all  amendments  to this  Registration  Statement,  and to file the  same,  with  all
  exhibits  thereto,  and all  other documents in connection  therewith,  with the
  Securities  and  Exchange  Commission,  granting  unto  each  said  attorney-in-fact  and
  agents  full power and  authority  to do  and  perform  each and every act in person,
  hereby  ratifying  and confirming all that said  attorneys-in-fact  and agents or  either
  of  them  or  their  or  his  or  her  substitute  or  substitutes  may  lawfully  do or
  cause  to be done by  virtue  hereof.
  Pursuant
  to the  requirements  of the  Securities  Act of  1933,  as  amended,  this  Registration
  Statement  has  been  signed by the following  persons in the  capacities and on the
  dates indicated.
  Signature
  Title
  Date
  /s/ Raymond P.
        Warrell, Jr., M.D.
  Chairman
        of the Board of Directors and Chief Executive
  Raymond P. Warrell,
        Jr., M.D.
  Officer
        (Principal Executive Officer)
  September
        15, 2005
  /s/ William P.
        Keane
  Senior
        Vice President, Chief Financial Officer and Corporate
  William P. Keane
  Secretary
        (Principal Accounting Officer)
  September
        15, 2005
  /s/ Martin Driscoll
  Martin Driscoll
  Director
  September
        15, 2005
  /s/ Jerome E. Groopman,
        M.D.
  Jerome E. Groopman,
        M.D.
  Director
  September
        15, 2005
  /s/ Betsy McCaughey,
        Ph.D.
  Betsy McCaughey, Ph.D.
  Director
  September
        15, 2005
  /s/ Christopher Parios
  Christopher Parios
  Director
  September
        15, 2005
  /s/ Daniel D. Von
        Hoff, M.D.
  Daniel D. Von Hoff,
        M.D.
  Director
  September
        15, 2005
  /s/ Harlan J. Wakoff
  Harlan J. Wakoff
  Director
  September
        15, 2005
  /s/ Douglas G.
        Watson
  Douglas G. Watson
  Director
  September
        15, 2005
  EXHIBIT  INDEX
  Exhibit
  Number
  Description
  Sequentially
  Numbered
  Page
  5
  Opinion
  of Davis Polk & Wardwell
  23.1
  Consent
  of Deloitte & Touche LLP
  23.2
  Consent
  of Davis Polk & Wardwell (included in Exhibit 5)
  24
  Power
  of Attorney (included on signature page)