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  <P STYLE="text-align: center; font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><B>As filed with
  the Securities and Exchange Commission on February 16, 2021</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: right"><B>Registration No. 333-</B>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</P>
  
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  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: right"></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center"><B>UNITED STATES</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center"><B>SECURITIES AND EXCHANGE
  COMMISSION</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center"><B>Washington, D.C. 20549</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center">&nbsp;</P>
  
  <!-- Field: Rule-Page --><DIV STYLE="margin-left: auto; margin-right: auto; width: 25%"><DIV STYLE="font-size: 1pt; border-top: Black 1.5pt solid">&nbsp;</DIV></DIV><!-- Field: /Rule-Page -->
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center"></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center"><B>FORM S-8</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center"><B>REGISTRATION STATEMENT</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center"><B><I>UNDER</I></B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center"><B><I>THE SECURITIES
  ACT OF 1933</I></B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center">&nbsp;</P>
  
  <!-- Field: Rule-Page --><DIV STYLE="margin-left: auto; margin-right: auto; width: 25%"><DIV STYLE="font-size: 1pt; border-top: Black 1.5pt solid">&nbsp;</DIV></DIV><!-- Field: /Rule-Page -->
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center"><B>LONGEVERON INC.</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center"><B>(Exact name of registrant
  as specified in its charter)</B></P>
  
  <P STYLE="text-align: center; font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt">&nbsp;</P>
  
  <!-- Field: Rule-Page --><DIV STYLE="margin-left: auto; margin-right: auto; width: 25%"><DIV STYLE="font-size: 1pt; border-top: Black 1.5pt solid">&nbsp;</DIV></DIV><!-- Field: /Rule-Page -->
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; text-align: center; margin-top: 0pt; margin-bottom: 0pt">&nbsp;</P>
  
  <TABLE CELLSPACING="0" CELLPADDING="0" STYLE="width: 100%; font: 10pt Times New Roman, Times, Serif; border-collapse: collapse">
  <TR>
      <TD STYLE="border-bottom: Black 1.5pt solid; vertical-align: top; padding-right: 3pt; padding-left: 3pt; font-size: 10pt; text-align: center; width: 49%"><FONT STYLE="font-size: 10pt"><B>Delaware</B></FONT></TD>
      <TD STYLE="padding-bottom: 1.5pt; vertical-align: bottom; padding-right: 3pt; padding-left: 3pt; font-size: 10pt; width: 2%">&nbsp;</TD>
      <TD STYLE="border-bottom: Black 1.5pt solid; vertical-align: top; padding-right: 3pt; padding-left: 3pt; font-size: 10pt; text-align: center; width: 49%"><FONT STYLE="font-size: 10pt"><B>33-0029027</B></FONT></TD></TR>
  <TR>
      <TD STYLE="vertical-align: top; padding-right: 3pt; padding-left: 3pt"><P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">(State or other jurisdiction of</P>
          <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">incorporation or organization)</P></TD>
      <TD STYLE="vertical-align: bottom; padding-right: 3pt; padding-left: 3pt; font-size: 10pt">&nbsp;</TD>
      <TD STYLE="vertical-align: top; padding-right: 3pt; padding-left: 3pt"><P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">(I.R.S. employer</P>
          <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">identification number)</P></TD></TR>
  </TABLE>
  <P STYLE="text-align: center; font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center"><B>1951 NW 7<SUP>TH</SUP> Avenue,
  Suite 520</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center"><B>Miami, Florida 33136</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center"><B>Telephone: (305) 909-0840</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center">(Address, including zip code, and telephone
  number, including area code, of registrant&rsquo;s principal executive offices)</P>
  
  <P STYLE="text-align: center; font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt">&nbsp;</P>
  
  <!-- Field: Rule-Page --><DIV STYLE="margin-left: auto; margin-right: auto; width: 25%"><DIV STYLE="font-size: 1pt; border-top: Black 1.5pt solid">&nbsp;</DIV></DIV><!-- Field: /Rule-Page -->
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; text-align: center; margin-top: 0pt; margin-bottom: 0pt">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center"><B>2017 Longeveron LLC
  Incentive Plan</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center"><B>Longeveron Inc. 2021
  Incentive Award Plan</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center">(Full title of the Plan(s))</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center">&nbsp;</P>
  
  <!-- Field: Rule-Page --><DIV STYLE="margin-left: auto; margin-right: auto; width: 25%"><DIV STYLE="font-size: 1pt; border-top: Black 1.5pt solid">&nbsp;</DIV></DIV><!-- Field: /Rule-Page -->
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center"><B>Geoff
  Green </B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center"><B>Chief
  Executive Officer </B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center"><B>Longeveron
  Inc.</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center"><B>1951 NW 7<SUP>th</SUP>
  Ave., Suite 520</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center"><B>Miami, FL 33136</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center"><B>(305) 909-0840</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center">(Name, address, including zip code, and
  telephone number, including area code, of agent for service)</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center">&nbsp;</P>
  
  <!-- Field: Rule-Page --><DIV STYLE="margin-left: auto; margin-right: auto; width: 25%"><DIV STYLE="font-size: 1pt; border-top: Black 1.5pt solid">&nbsp;</DIV></DIV><!-- Field: /Rule-Page -->
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center"><B><I>Copies to:</I></B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center"><B>&nbsp;</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center"><B>Jennifer Minter, Esq.<BR>
  Brian North, Esq.</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center"><B>Buchanan Ingersoll &amp;
  Rooney PC</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center"><B>Union Trust Building</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center"><B>501 Grant Street, Suite
  200</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center"><B>Pittsburgh, PA 15219</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center"><B>(412) 562-8800</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center"><B>&nbsp;</B></P>
  
  <!-- Field: Rule-Page --><DIV STYLE="margin-left: auto; margin-right: auto; width: 25%"><DIV STYLE="font-size: 1pt; border-top: Black 1.5pt solid">&nbsp;</DIV></DIV><!-- Field: /Rule-Page -->
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Indicate by check mark whether the registrant is a large accelerated
  filer, an accelerated filer, a nonaccelerated filer, smaller reporting company, or an emerging growth company. See the definitions
  of &ldquo;large accelerated filer,&rdquo; &ldquo;accelerated filer,&rdquo; &ldquo;smaller reporting company,&rdquo; and &ldquo;emerging
  growth company&rdquo; in Rule 12b-2 of the Exchange Act.</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
  
  <TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
  <TR STYLE="vertical-align: bottom">
      <TD STYLE="width: 25%"><FONT STYLE="font-size: 10pt">Large Accelerated Filer</FONT></TD>
      <TD STYLE="width: 45%"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#9744;</FONT></TD>
      <TD STYLE="width: 25%"><FONT STYLE="font-size: 10pt">Accelerated filer</FONT></TD>
      <TD STYLE="width: 5%"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#9744;</FONT></TD></TR>
  <TR STYLE="vertical-align: bottom">
      <TD><FONT STYLE="font-size: 10pt">Non-accelerated filer</FONT></TD>
      <TD><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#9746;</FONT></TD>
      <TD><FONT STYLE="font-size: 10pt">Smaller reporting company</FONT></TD>
      <TD><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#9746;</FONT></TD></TR>
  <TR STYLE="vertical-align: bottom">
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD><FONT STYLE="font-size: 10pt">Emerging growth company</FONT></TD>
      <TD><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#9746;</FONT></TD></TR>
  </TABLE>
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">If an emerging growth company, indicate by check mark if the
  registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards
  provided pursuant to Section 7(a)(2)(B) of Securities Act. <FONT STYLE="font-family: Times New Roman, Times, Serif">&#9744;</FONT></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
  
  
  <!-- Field: Page; Sequence: 1 -->
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  <P STYLE="text-align: center; font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; text-align: center; margin-top: 0pt; margin-bottom: 0pt"><B>CALCULATION OF REGISTRATION FEE </B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; text-align: center; margin-top: 0pt; margin-bottom: 0pt">&nbsp;</P>
  
  <TABLE CELLPADDING="0" CELLSPACING="0" STYLE="border-collapse: collapse; width: 100%; font: 10pt Times New Roman, Times, Serif">
  <TR STYLE="vertical-align: bottom">
      <TD STYLE="white-space: nowrap; text-align: center; border-bottom: Black 1.5pt solid"><P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: left"><B>Title
  of Each Class of Securities to be Registered</B></P></TD><TD STYLE="white-space: nowrap; padding-bottom: 1.5pt">&nbsp;</TD>
      <TD COLSPAN="2" STYLE="white-space: nowrap; text-align: center; border-bottom: Black 1.5pt solid"><P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>Amount</B></P> <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>to be</B></P> <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>Registered <SUP>(1)</SUP></B></P></TD><TD STYLE="white-space: nowrap; padding-bottom: 1.5pt"><SUP>&nbsp;</SUP></TD><TD STYLE="white-space: nowrap; padding-bottom: 1.5pt">&nbsp;</TD>
      <TD COLSPAN="2" STYLE="white-space: nowrap; text-align: center; border-bottom: Black 1.5pt solid"><P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>Proposed Maximum</B></P> <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>Aggregate Offering<BR> Price</B></P> <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>Per Share<SUP>(2)</SUP></B></P></TD><TD STYLE="white-space: nowrap; padding-bottom: 1.5pt">&nbsp;</TD><TD STYLE="white-space: nowrap; padding-bottom: 1.5pt">&nbsp;</TD>
      <TD COLSPAN="2" STYLE="white-space: nowrap; text-align: center; border-bottom: Black 1.5pt solid"><P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>Proposed Maximum</B></P> <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>Aggregate Offering</B></P> <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>Price</B></P></TD><TD STYLE="white-space: nowrap; padding-bottom: 1.5pt">&nbsp;</TD><TD STYLE="white-space: nowrap; padding-bottom: 1.5pt">&nbsp;</TD>
      <TD COLSPAN="2" STYLE="white-space: nowrap; text-align: center; border-bottom: Black 1.5pt solid"><P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>Amount of</B></P> <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>Registration Fee</B></P></TD><TD STYLE="white-space: nowrap; padding-bottom: 1.5pt">&nbsp;</TD></TR>
  <TR STYLE="vertical-align: bottom; background-color: rgb(204,238,255)">
      <TD STYLE="text-indent: -0.125in; padding-left: 0.125in; width: 52%">Class A Common Stock, $0.001 par value per share</TD><TD STYLE="width: 1%">&nbsp;</TD>
      <TD STYLE="width: 1%; text-align: left">&nbsp;</TD><TD STYLE="width: 9%; text-align: right">2,074,402</TD><TD STYLE="width: 1%; text-align: left"><P STYLE="margin: 0pt 0; font: 10pt Times New Roman, Times, Serif"><SUP>(3)</SUP></P></TD><TD STYLE="width: 1%">&nbsp;</TD>
      <TD STYLE="width: 1%; text-align: left">$</TD><TD STYLE="width: 9%; text-align: right">10.00</TD><TD STYLE="width: 1%; text-align: left">&nbsp;</TD><TD STYLE="width: 1%">&nbsp;</TD>
      <TD STYLE="width: 1%; text-align: left">$</TD><TD STYLE="width: 9%; text-align: right">20,744,020</TD><TD STYLE="width: 1%; text-align: left">&nbsp;</TD><TD STYLE="width: 1%">&nbsp;</TD>
      <TD STYLE="width: 1%; text-align: left">$</TD><TD STYLE="width: 9%; text-align: right">2,263.17</TD><TD STYLE="width: 1%; text-align: left">&nbsp;</TD></TR>
  </TABLE>
  
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
  
  <TABLE CELLPADDING="0" CELLSPACING="0" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 0; width: 100%"><TR STYLE="vertical-align: top; text-align: left">
  <TD STYLE="width: 0in"></TD><TD STYLE="width: 0.25in; text-align: left">(1)</TD><TD STYLE="text-align: left">Pursuant to Rule 416 under the Securities Act of 1933,
  as amended (the &ldquo;Securities Act&rdquo;), this registration statement also registers an indeterminate number of additional
  shares that may be issued pursuant to the above-named plans as the result of any future stock dividend, stock split, recapitalization
  or any other similar transaction effected without the receipt of consideration which results in an increase in the number of our
  outstanding shares of common stock.</TD>
  </TR></TABLE>
  
  <TABLE CELLPADDING="0" CELLSPACING="0" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 0; width: 100%"><TR STYLE="vertical-align: top; text-align: left">
  <TD STYLE="width: 0in"></TD><TD STYLE="width: 0.25in; text-align: left">(2)</TD><TD STYLE="text-align: left">This estimate is made pursuant to Rule 457 of the Securities
  Act solely for purposes of calculating the registration fee. The computation is based upon the initial public offering price of
  the registrant&rsquo;s Class A Common Stock set forth on the cover page of the registrant&rsquo;s prospectus dated February 12,
  2021 relating to its initial public offering.</TD>
  </TR></TABLE>
  
  <TABLE CELLPADDING="0" CELLSPACING="0" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 0; width: 100%"><TR STYLE="vertical-align: top; text-align: left">
  <TD STYLE="width: 0in"></TD><TD STYLE="width: 0.25in; text-align: left">(3)</TD><TD STYLE="text-align: left">The number of shares to be registered under the respective
  plans are as follows: 2017 Longeveron LLC Incentive Plan- 855,247; and Longeveron Inc. 2021 Incentive Award Plan- 1,219,155.</TD>
  </TR></TABLE>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 5.9pt">&nbsp;</P>
  
  <!-- Field: Rule-Page --><DIV STYLE="width: 100%"><DIV STYLE="font-size: 1pt; border-top: Black 1pt solid; border-bottom: Black 2pt solid">&nbsp;</DIV></DIV><!-- Field: /Rule-Page -->
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 5.9pt">&nbsp;</P>
  
  
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  <P STYLE="text-align: center; font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><B>&nbsp;</B></P>
  
  <P STYLE="margin-right: 0; font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center"><B>PART I</B></P>
  
  <P STYLE="margin-right: 0; font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center"><B>INFORMATION REQUIRED IN THE
  SECTION 10(a) PROSPECTUS</B></P>
  
  <P STYLE="margin-right: 0; text-align: center; font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">The documents containing the information specified in Part
  I of Form S-8 will be sent or given to participants as specified by Rule 428(b)(1) of the Securities Act. These documents and
  the documents incorporated by reference into this Registration Statement pursuant to Item 3 of Part II of this registration statement,
  taken together, constitute a prospectus that meets the requirements of Section 10(a) of the Securities Act.</P>
  
  <P STYLE="margin-right: 0; text-align: center; font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin-right: 0; text-align: center; margin-top: 0pt; margin-bottom: 0pt"></P>
  
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  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin-right: 0; text-align: center; margin-top: 0pt; margin-bottom: 0pt">&nbsp;</P>
  
  <P STYLE="margin-right: 0; font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center"><B>PART II</B></P>
  
  <P STYLE="margin-right: 0; font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center"><B>INFORMATION REQUIRED IN THE
  REGISTRATION STATEMENT</B></P>
  
  <P STYLE="margin-right: 0; font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: left"><I>In this registration statement,
  Longeveron Inc. is sometimes referred to as &ldquo;Registrant,&rdquo; &ldquo;we,&rdquo; &ldquo;us&rdquo; or &ldquo;our.&rdquo;</I></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: left"><B>&nbsp;</B></P>
  
  <P STYLE="margin: 0 0 0 0in; font: 10pt Times New Roman, Times, Serif; text-indent: 0in; text-align: left"><B>Item
  3. Incorporation of Documents by Reference.</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; background-color: white">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; background-color: white">The Securities and Exchange Commission
  (&ldquo;SEC&rdquo;) allows us to &ldquo;incorporate by reference&rdquo; the information we file with them, which means that we
  can disclose important information to you by referring you to those documents. The information incorporated by reference is considered
  to be part of this registration statement, and later information filed with the SEC will update and supersede this information.
  We hereby incorporate by reference into this registration statement the following documents previously filed with the SEC:</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; background-color: white">&nbsp;</P>
  
  <TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; background-color: white; border-collapse: collapse">
  <TR>
      <TD STYLE="width: 0.25in">&nbsp;</TD>
      <TD STYLE="vertical-align: top; width: 0.25in"><FONT STYLE="font-size: 10pt">(a)</FONT></TD>
      <TD STYLE="vertical-align: top"><FONT STYLE="font-size: 10pt">The prospectus filed by the Registrant with the SEC pursuant
      to Rule 424(b) under the Securities Act, on February 12, 2021 relating to the registration statement on Form&nbsp;S-1,&nbsp;as
      amended (Registration No. 333-252234),&nbsp;which contains the Registrant&rsquo;s audited financial statements for the latest
      fiscal year for which such statements have been filed; and</FONT></TD></TR>
  </TABLE>
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; background-color: white">&nbsp;</P>
  
  <TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; background-color: white; border-collapse: collapse">
  <TR>
      <TD STYLE="width: 0.25in">&nbsp;</TD>
      <TD STYLE="vertical-align: top; width: 0.25in"><FONT STYLE="font-size: 10pt">(b)</FONT></TD>
      <TD STYLE="vertical-align: top"><FONT STYLE="font-size: 10pt">The description of the Registrant&rsquo;s common stock set forth
      in the Registrant&rsquo;s registration statement on Form&nbsp;8-A&nbsp;(File&nbsp;No.&nbsp;001-40060), filed by the Registrant
      with the SEC under Section&nbsp;12(b) of the Securities Exchange Act of 1934, as amended (the &ldquo;Exchange Act&rdquo;),
      on February 11, 2021, including any amendments or reports filed for the purpose of updating such description.</FONT></TD></TR>
  </TABLE>
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; background-color: white">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; background-color: white">In addition, all documents filed by
  the Registrant pursuant to Section&nbsp;13(a), 13(c), 14 or 15(d) of the Exchange Act subsequent to the filing of this registration
  statement and prior to the filing of a post-effective amendment which indicates that all securities offered hereby have been sold
  or which de-registers all securities then remaining unsold shall be deemed to be incorporated by reference into this registration
  statement and to be a part hereof from the date of filing such documents, except as to specific sections of such statements as
  set forth therein. Any statement contained in a document incorporated or deemed to be incorporated by reference herein shall be
  deemed to be modified or superseded for purposes of this registration statement to the extent that a statement contained herein
  or in any other subsequently filed document which also is incorporated or deemed to be incorporated by reference herein modifies
  or supersedes such statement. Any statement contained herein shall be deemed to be modified or superseded for purposes of this
  registration statement to the extent that a statement contained in any subsequently filed document which also is incorporated
  or deemed to be incorporated by reference herein modifies or supersedes such statement. Any such statement so modified or superseded
  shall not be deemed, except as so modified or superseded, to constitute a part of this registration statement.</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; background-color: white">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; background-color: white">Under no circumstances shall any information
  furnished under Item 2.02 or 7.01 of Form&nbsp;8-K be deemed incorporated herein by reference unless such Form&nbsp;8-K expressly
  provides to the contrary.</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 27pt; text-align: left">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: left"><B>Item 4. Description of Securities.</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: left">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: left">Not applicable.</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: left">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: left"><B>Item 5. Interests of Named
  Experts and Counsel.</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: left">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: left">The validity of the securities
  registered hereby has been passed upon for the Company by Buchanan Ingersoll&nbsp;&amp; Rooney PC (&ldquo;BIR&rdquo;), Pittsburgh,
  Pennsylvania. Certain attorneys affiliated with BIR beneficially own an aggregate of 20,000 shares of our Class&nbsp;A Common
  Stock.</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 27pt 0pt 0; text-align: left">&nbsp;</P>
  
  
  <!-- Field: Page; Sequence: 4; Options: NewSection; Value: 1 -->
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  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: left"><B>Item 6. Indemnification of
  Directors and Officers.</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: left">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: left">Section 102 of the Delaware General
  Corporation Law (&ldquo;DGCL&rdquo;) permits a corporation to eliminate the personal liability of directors of a corporation
  to the corporation or its stockholders for monetary damages for a breach of fiduciary duty as a director, except where the
  director breached his duty of loyalty, failed to act in good faith, engaged in intentional misconduct or knowingly violated a
  law, authorized the payment of a dividend or approved a stock repurchase in violation of Delaware corporate law or obtained
  an improper personal benefit. Our certificate of incorporation provides that no director shall be personally liable to us or
  our stockholders for monetary damages for any breach of fiduciary duty as a director, notwithstanding any provision of law
  imposing such liability, except to the extent that the DGCL prohibits the elimination or limitation of liability of directors
  for breaches of fiduciary duty.</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: left">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: left">Section 145 of the DGCL provides
  that a corporation has the power to indemnify a director, officer, employee, or agent of the corporation, or a person serving
  at the request of the corporation for another corporation, partnership, joint venture, trust or other enterprise in related capacities
  against expenses (including attorneys&rsquo; fees), judgments, fines and amounts paid in settlement actually and reasonably incurred
  by the person in connection with an action, suit or proceeding to which he was or is a party or is threatened to be made a party
  to any threatened, ending or completed action, suit or proceeding by reason of such position, if such person acted in good faith
  and in a manner he reasonably believed to be in or not opposed to the best interests of the corporation, and, in any criminal
  action or proceeding, had no reasonable cause to believe his conduct was unlawful, except that, in the case of actions brought
  by or in the right of the corporation, no indemnification shall be made with respect to any claim, issue or matter as to which
  such person shall have been adjudged to be liable to the corporation unless and only to the extent that the Court of Chancery
  or other adjudicating court determines that, despite the adjudication of liability but in view of all of the circumstances of
  the case, such person is fairly and reasonably entitled to indemnity for such expenses which the Court of Chancery or such other
  court shall deem proper.</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: left">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: left">Our certificate of incorporation
  provides that we will indemnify each person who was or is a party or threatened to be made a party to any threatened, pending
  or completed action, suit or proceeding (other than an action by or in the right of us) by reason of the fact that he or she is
  or was, or has agreed to become, a director or officer, or is or was serving, or has agreed to serve, at our request as a director,
  officer, partner, employee or trustee of, or in a similar capacity with, another corporation, partnership, joint venture, trust
  or other enterprise (all such persons being referred to as an &ldquo;Indemnitee&rdquo;), or by reason of any action alleged to
  have been taken or omitted in such capacity, against all expenses (including attorneys&rsquo; fees), judgments, fines and amounts
  paid in settlement actually and reasonably incurred in connection with such action, suit or proceeding and any appeal therefrom,
  if such Indemnitee acted in good faith and in a manner he or she reasonably believed to be in, or not opposed to, our best interests,
  and, with respect to any criminal action or proceeding, he or she had no reasonable cause to believe his or her conduct was unlawful.
  Our certificate of incorporation provides that we will indemnify any Indemnitee who was or is a party to an action or suit by
  or in the right of us to procure a judgment in our favor by reason of the fact that the Indemnitee is or was, or has agreed to
  become, a director or officer, or is or was serving, or has agreed to serve, at our request as a director, officer, partner, employee
  or trustee of, or in a similar capacity with, another corporation, partnership, joint venture, trust or other enterprise, or by
  reason of any action alleged to have been taken or omitted in such capacity, against all expenses (including attorneys&rsquo;
  fees) and, to the extent permitted by law, amounts paid in settlement actually and reasonably incurred in connection with such
  action, suit or proceeding, and any appeal therefrom, if the Indemnitee acted in good faith and in a manner he or she reasonably
  believed to be in, or not opposed to, our best interests, except that no indemnification shall be made with respect to any claim,
  issue or matter as to which such person shall have been adjudged to be liable to us, unless a court determines that, despite such
  adjudication but in view of all of the circumstances, he or she is entitled to indemnification of such expenses. Notwithstanding
  the foregoing, to the extent that any Indemnitee has been successful, on the merits or otherwise, he or she will be indemnified
  by us against all expenses (including attorneys&rsquo; fees) actually and reasonably incurred in connection therewith. Expenses
  must be advanced to an Indemnitee under certain circumstances.</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: left">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: left">We have entered into indemnification
  agreements with each of our directors and officers. These indemnification agreements may require us, among other things, to indemnify
  our directors and officers for some expenses, including attorneys&rsquo; fees, judgments, fines and settlement amounts incurred
  by a director or officer in any action or proceeding arising out of his or her service as one of our directors or officers, or
  any of our subsidiaries or any other company or enterprise to which the person provides services at our request.</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: left">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: left">We maintain a general liability
  insurance policy that covers certain liabilities of directors and officers of our corporation arising out of claims based on acts
  or omissions in their capacities as directors or officers.</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: left">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: left"><B>Item 7. Exemption from Registration
  Claimed.</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: left">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: left">Not applicable.</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 27pt 0pt 0; text-align: left">&nbsp;</P>
  
  
  <!-- Field: Page; Sequence: 5; Value: 1 -->
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      <DIV STYLE="break-before: page; margin-top: 6pt; margin-bottom: 12pt"><P STYLE="margin: 0pt">&nbsp;</P></DIV>
      <!-- Field: /Page -->
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 0; margin-left: 0in; text-indent: 0in; text-align: left"><B>Item
  8. Exhibits.</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
  
  <TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; background-color: white; border-collapse: collapse">
  <TR STYLE="vertical-align: bottom">
      <TD ROWSPAN="2" STYLE="border-bottom: Black 1.5pt solid; white-space: nowrap"><P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B>Exhibit<BR>
          Number</B></P></TD>
      <TD ROWSPAN="2" STYLE="padding-bottom: 1.5pt">&nbsp;</TD>
      <TD ROWSPAN="2" STYLE="border-bottom: Black 1.5pt solid; text-align: center"><FONT STYLE="font-size: 10pt"><B>Exhibit Description</B></FONT></TD>
      <TD STYLE="padding-bottom: 1.5pt">&nbsp;</TD>
      <TD COLSPAN="7" STYLE="border-bottom: Black 1.5pt solid; text-align: center"><FONT STYLE="font-size: 10pt"><B>Incorporated by
      Reference</B></FONT></TD>
      <TD ROWSPAN="2" STYLE="padding-bottom: 1.5pt">&nbsp;</TD>
      <TD ROWSPAN="2" STYLE="border-bottom: Black 1.5pt solid; text-align: center"><FONT STYLE="font-size: 10pt"><B>Filed<BR>
      Herewith</B></FONT></TD></TR>
  <TR STYLE="vertical-align: bottom">
      <TD STYLE="padding-bottom: 1.5pt">&nbsp;</TD>
      <TD STYLE="border-bottom: Black 1.5pt solid; text-align: center"><FONT STYLE="font-size: 10pt"><B>Form</B></FONT></TD>
      <TD STYLE="padding-bottom: 1.5pt">&nbsp;</TD>
      <TD STYLE="border-bottom: Black 1.5pt solid; text-align: center"><FONT STYLE="font-size: 10pt"><B>File No.</B></FONT></TD>
      <TD STYLE="padding-bottom: 1.5pt">&nbsp;</TD>
      <TD STYLE="border-bottom: Black 1.5pt solid; text-align: center"><FONT STYLE="font-size: 10pt"><B>Exhibit</B></FONT></TD>
      <TD STYLE="padding-bottom: 1.5pt">&nbsp;</TD>
      <TD STYLE="border-bottom: Black 1.5pt solid; text-align: center"><FONT STYLE="font-size: 10pt"><B>Filing<BR>
      Date</B></FONT></TD></TR>
  <TR STYLE="background-color: rgb(204,238,255)">
      <TD STYLE="vertical-align: top; padding-left: 12pt; text-align: center; text-indent: -12pt; width: 6%"><FONT STYLE="font-size: 10pt">4.1</FONT></TD>
      <TD STYLE="vertical-align: bottom; width: 1%">&nbsp;</TD>
      <TD STYLE="vertical-align: bottom; width: 45%"><A HREF="ea135545ex4-1_longeveron.htm"><FONT STYLE="font-size: 10pt">Certificate of Incorporation of Longeveron Inc.</FONT></A></TD>
      <TD STYLE="vertical-align: bottom; width: 1%">&nbsp;</TD>
      <TD STYLE="vertical-align: bottom; text-align: center; width: 6%">&nbsp;</TD>
      <TD STYLE="vertical-align: bottom; width: 1%">&nbsp;</TD>
      <TD STYLE="vertical-align: bottom; text-align: center; width: 11%">&nbsp;</TD>
      <TD STYLE="vertical-align: bottom; width: 1%">&nbsp;</TD>
      <TD STYLE="vertical-align: bottom; text-align: center; width: 6%">&nbsp;</TD>
      <TD STYLE="vertical-align: bottom; width: 1%">&nbsp;</TD>
      <TD STYLE="vertical-align: top; width: 11%">&nbsp;</TD>
      <TD STYLE="vertical-align: bottom; width: 1%">&nbsp;</TD>
      <TD STYLE="vertical-align: bottom; text-align: center; width: 9%"><FONT STYLE="font-size: 10pt">X</FONT></TD></TR>
  <TR STYLE="background-color: White">
      <TD STYLE="vertical-align: top; padding-left: 12pt; text-align: center; text-indent: -12pt"><FONT STYLE="font-size: 10pt">4.2</FONT></TD>
      <TD STYLE="vertical-align: bottom">&nbsp;</TD>
      <TD STYLE="vertical-align: bottom"><A HREF="ea135545ex4-2_longeveron.htm"><FONT STYLE="font-size: 10pt">Bylaws of Longeveron Inc.</FONT></A></TD>
      <TD STYLE="vertical-align: bottom">&nbsp;</TD>
      <TD STYLE="vertical-align: bottom; text-align: center">&nbsp;</TD>
      <TD STYLE="vertical-align: bottom">&nbsp;</TD>
      <TD STYLE="vertical-align: bottom; text-align: center">&nbsp;</TD>
      <TD STYLE="vertical-align: bottom">&nbsp;</TD>
      <TD STYLE="vertical-align: bottom; text-align: center">&nbsp;</TD>
      <TD STYLE="vertical-align: bottom">&nbsp;</TD>
      <TD STYLE="vertical-align: top">&nbsp;</TD>
      <TD STYLE="vertical-align: bottom">&nbsp;</TD>
      <TD STYLE="vertical-align: bottom; text-align: center"><FONT STYLE="font-size: 10pt">X</FONT></TD></TR>
  <TR STYLE="background-color: rgb(204,238,255)">
      <TD STYLE="vertical-align: top; padding-left: 12pt; text-align: center; text-indent: -12pt"><FONT STYLE="font-size: 10pt">4.3</FONT></TD>
      <TD STYLE="vertical-align: bottom">&nbsp;</TD>
      <TD STYLE="vertical-align: bottom"><FONT STYLE="font-size: 10pt"><A HREF="http://www.sec.gov/Archives/edgar/data/1721484/000121390021006475/ea134523ex4-1_longeveron.htm">Specimen Class A Common Stock Certificate evidencing the shares of Class A common stock</A></FONT></TD>
      <TD STYLE="vertical-align: bottom">&nbsp;</TD>
      <TD STYLE="vertical-align: bottom; text-align: center"><FONT STYLE="font-size: 10pt">S-1/A</FONT></TD>
      <TD STYLE="vertical-align: bottom">&nbsp;</TD>
      <TD STYLE="vertical-align: bottom; text-align: right"><FONT STYLE="font-size: 10pt">333-252234</FONT></TD>
      <TD STYLE="vertical-align: bottom">&nbsp;</TD>
      <TD STYLE="vertical-align: bottom; text-align: center"><FONT STYLE="font-size: 10pt">4.1</FONT></TD>
      <TD STYLE="vertical-align: bottom">&nbsp;</TD>
      <TD STYLE="vertical-align: bottom; text-align: center"><FONT STYLE="font-size: 10pt">02/03/2021</FONT></TD>
      <TD STYLE="vertical-align: bottom">&nbsp;</TD>
      <TD STYLE="vertical-align: bottom">&nbsp;</TD></TR>
  <TR STYLE="background-color: White">
      <TD STYLE="vertical-align: top; padding-left: 12pt; text-align: center; text-indent: -12pt"><FONT STYLE="font-size: 10pt">5.1</FONT></TD>
      <TD STYLE="vertical-align: bottom">&nbsp;</TD>
      <TD STYLE="vertical-align: bottom"><A HREF="ea135545ex5-1_longeveron.htm"><FONT STYLE="font-size: 10pt"><U STYLE="text-decoration: none">Opinion of Buchanan Ingersoll &amp; Rooney PC</U></FONT></A></TD>
      <TD STYLE="vertical-align: bottom">&nbsp;</TD>
      <TD STYLE="vertical-align: bottom">&nbsp;</TD>
      <TD STYLE="vertical-align: bottom">&nbsp;</TD>
      <TD STYLE="vertical-align: top">&nbsp;</TD>
      <TD STYLE="vertical-align: bottom">&nbsp;</TD>
      <TD STYLE="vertical-align: bottom">&nbsp;</TD>
      <TD STYLE="vertical-align: bottom">&nbsp;</TD>
      <TD STYLE="vertical-align: bottom">&nbsp;</TD>
      <TD STYLE="vertical-align: bottom">&nbsp;</TD>
      <TD STYLE="vertical-align: bottom; text-align: center"><FONT STYLE="font-size: 10pt">X</FONT></TD></TR>
  <TR STYLE="background-color: rgb(204,238,255)">
      <TD STYLE="vertical-align: top; padding-left: 12pt; text-align: center; text-indent: -12pt"><FONT STYLE="font-size: 10pt">10.1</FONT></TD>
      <TD STYLE="vertical-align: bottom">&nbsp;</TD>
      <TD STYLE="vertical-align: bottom"><A HREF="http://www.sec.gov/Archives/edgar/data/1721484/000121390021002924/ea133523ex10-12_longeveron.htm"><FONT STYLE="font-size: 10pt">2017 Longeveron LLC Incentive Plan</FONT></A></TD>
      <TD STYLE="vertical-align: bottom">&nbsp;</TD>
      <TD STYLE="vertical-align: bottom; text-align: center"><FONT STYLE="font-size: 10pt">S-1/A</FONT></TD>
      <TD STYLE="vertical-align: bottom">&nbsp;</TD>
      <TD STYLE="vertical-align: bottom; text-align: right"><FONT STYLE="font-size: 10pt">333-252234</FONT></TD>
      <TD STYLE="vertical-align: bottom">&nbsp;</TD>
      <TD STYLE="vertical-align: bottom; text-align: center"><FONT STYLE="font-size: 10pt">10.12</FONT></TD>
      <TD STYLE="vertical-align: bottom">&nbsp;</TD>
      <TD STYLE="vertical-align: bottom; text-align: center"><FONT STYLE="font-size: 10pt">02/03/2021</FONT></TD>
      <TD STYLE="vertical-align: bottom">&nbsp;</TD>
      <TD STYLE="vertical-align: bottom">&nbsp;</TD></TR>
  <TR STYLE="background-color: White">
      <TD STYLE="vertical-align: top; padding-left: 12pt; text-align: center; text-indent: -12pt"><FONT STYLE="font-size: 10pt">10.2</FONT></TD>
      <TD STYLE="vertical-align: bottom">&nbsp;</TD>
      <TD STYLE="vertical-align: bottom"><FONT STYLE="font-size: 10pt"><A HREF="http://www.sec.gov/Archives/edgar/data/1721484/000121390021006475/ea134523ex10-13_longeveron.htm">Longeveron Inc. 2021 Incentive Award Plan</A></FONT></TD>
      <TD STYLE="vertical-align: bottom">&nbsp;</TD>
      <TD STYLE="vertical-align: bottom; text-align: center"><FONT STYLE="font-size: 10pt">S-1/A</FONT></TD>
      <TD STYLE="vertical-align: bottom">&nbsp;</TD>
      <TD STYLE="vertical-align: top; text-align: right"><FONT STYLE="font-size: 10pt">333-252234</FONT></TD>
      <TD STYLE="vertical-align: bottom">&nbsp;</TD>
      <TD STYLE="vertical-align: bottom; text-align: center"><FONT STYLE="font-size: 10pt">10.13</FONT></TD>
      <TD STYLE="vertical-align: bottom">&nbsp;</TD>
      <TD STYLE="vertical-align: bottom; text-align: center"><FONT STYLE="font-size: 10pt">02/03/2021</FONT></TD>
      <TD STYLE="vertical-align: bottom">&nbsp;</TD>
      <TD STYLE="vertical-align: bottom">&nbsp;</TD></TR>
  <TR STYLE="background-color: rgb(204,238,255)">
      <TD STYLE="vertical-align: top; padding-left: 12pt; text-align: center; text-indent: -12pt"><FONT STYLE="font-size: 10pt">23.1</FONT></TD>
      <TD STYLE="vertical-align: bottom">&nbsp;</TD>
      <TD STYLE="vertical-align: bottom"><FONT STYLE="font-size: 10pt"><A HREF="ea135545ex23-1_longeveron.htm" STYLE="-sec-extract: exhibit">Consent of Independent Registered Public Accounting Firm</A></FONT></TD>
      <TD STYLE="vertical-align: bottom">&nbsp;</TD>
      <TD STYLE="vertical-align: bottom">&nbsp;</TD>
      <TD STYLE="vertical-align: bottom">&nbsp;</TD>
      <TD STYLE="vertical-align: bottom">&nbsp;</TD>
      <TD STYLE="vertical-align: bottom">&nbsp;</TD>
      <TD STYLE="vertical-align: bottom">&nbsp;</TD>
      <TD STYLE="vertical-align: bottom">&nbsp;</TD>
      <TD STYLE="vertical-align: bottom">&nbsp;</TD>
      <TD STYLE="vertical-align: bottom">&nbsp;</TD>
      <TD STYLE="vertical-align: bottom; text-align: center"><FONT STYLE="font-size: 10pt">X</FONT></TD></TR>
  <TR STYLE="background-color: White">
      <TD STYLE="vertical-align: top; padding-left: 12pt; text-align: center; text-indent: -12pt"><FONT STYLE="font-size: 10pt">23.2</FONT></TD>
      <TD STYLE="vertical-align: bottom">&nbsp;</TD>
      <TD STYLE="vertical-align: bottom"><A HREF="ea135545ex5-1_longeveron.htm"><FONT STYLE="font-size: 10pt">Consent of Buchanan Ingersoll &amp; Rooney PC (included in Exhibit&nbsp;5.1 hereto)</FONT></A></TD>
      <TD STYLE="vertical-align: bottom">&nbsp;</TD>
      <TD STYLE="vertical-align: bottom">&nbsp;</TD>
      <TD STYLE="vertical-align: bottom">&nbsp;</TD>
      <TD STYLE="vertical-align: bottom">&nbsp;</TD>
      <TD STYLE="vertical-align: bottom">&nbsp;</TD>
      <TD STYLE="vertical-align: bottom">&nbsp;</TD>
      <TD STYLE="vertical-align: bottom">&nbsp;</TD>
      <TD STYLE="vertical-align: bottom">&nbsp;</TD>
      <TD STYLE="vertical-align: bottom">&nbsp;</TD>
      <TD STYLE="vertical-align: bottom; text-align: center"><FONT STYLE="font-size: 10pt">X</FONT></TD></TR>
  <TR STYLE="background-color: rgb(204,238,255)">
      <TD STYLE="vertical-align: top; padding-left: 12pt; text-align: center; text-indent: -12pt"><FONT STYLE="font-size: 10pt">24.1</FONT></TD>
      <TD STYLE="vertical-align: bottom">&nbsp;</TD>
      <TD STYLE="vertical-align: bottom"><FONT STYLE="font-size: 10pt"><A HREF="#poa_001">Power of Attorney (see signature page)</A></FONT></TD>
      <TD STYLE="vertical-align: bottom">&nbsp;</TD>
      <TD STYLE="vertical-align: bottom">&nbsp;</TD>
      <TD STYLE="vertical-align: bottom">&nbsp;</TD>
      <TD STYLE="vertical-align: bottom">&nbsp;</TD>
      <TD STYLE="vertical-align: bottom">&nbsp;</TD>
      <TD STYLE="vertical-align: bottom">&nbsp;</TD>
      <TD STYLE="vertical-align: bottom">&nbsp;</TD>
      <TD STYLE="vertical-align: bottom">&nbsp;</TD>
      <TD STYLE="vertical-align: bottom">&nbsp;</TD>
      <TD STYLE="vertical-align: bottom; text-align: center"><FONT STYLE="font-size: 10pt">X</FONT></TD></TR>
  </TABLE>
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; background-color: white"><B>&nbsp;</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; background-color: white"><B>Item&nbsp;9. Undertakings.</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 263.5pt 0pt 0.25in; text-align: center">&nbsp;</P>
  
  <TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
  <TD STYLE="width: 0"></TD><TD STYLE="width: 0.25in">(a)</TD><TD>The undersigned Registrant hereby undertakes:</TD></TR></TABLE>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in">&nbsp;</P>
  
  <TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
  <TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in">(1)</TD><TD>To file, during any period in which offers or sales are being
                                           made, a post-effective amendment to this registration statement,</TD></TR></TABLE>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in">&nbsp;</P>
  
  <TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
  <TD STYLE="width: 0.5in"></TD><TD STYLE="width: 0.5in">(i)</TD><TD>to include any prospectus required by Section&nbsp;10(a)(3)
                                           of the Securities Act;</TD></TR></TABLE>
  
  <TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
  <TD STYLE="width: 0.5in"></TD><TD STYLE="width: 0.5in">(ii)</TD><TD>to reflect in the prospectus any facts or events arising after
                                           the effective date of this registration statement (or the most recent post-effective
                                           amendment thereof) which, individually or in the aggregate, represent a fundamental change
                                           in the information set forth in this registration statement. Notwithstanding the foregoing,
                                           any increase or decrease in volume of securities offered (if the total dollar value of
                                           securities offered would not exceed that which was registered) and any deviation from
                                           the low or high end of the estimated maximum offering range may be reflected in the form
                                           of prospectus filed with the SEC pursuant to Rule 424(b) if, in the aggregate, the changes
                                           in volume and price represent no more than 20% change in the maximum aggregate offering
                                           price set forth in the &ldquo;Calculation of Registration Fee&rdquo; table in the effective
                                           registration statement; and</TD></TR></TABLE>
  
  <TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
  <TD STYLE="width: 0.5in"></TD><TD STYLE="width: 0.5in">(iii)</TD><TD>to include any material information with respect to the plan
                                           of distribution not previously disclosed in this registration statement or any material
                                           change to such information in this registration statement;</TD></TR></TABLE>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><I>&nbsp;</I></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><I>provided, however</I>, that paragraphs (a)(1)(i) and (a)(1)(ii)
  do not apply if this registration statement is on Form&nbsp;S-8 and the information required to be included in a post-effective
  amendment by those paragraphs is contained in reports filed with or furnished to the SEC by the Registrant pursuant to Section&nbsp;13
  or Section&nbsp;15(d) of the Exchange Act that are incorporated by reference in this registration statement.</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
  
  <TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
  <TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in">(2)</TD><TD>That, for the purpose of determining any liability under
                                           the Securities Act, each such post-effective amendment shall be deemed to be a new registration
                                           statement relating to the securities offered therein, and the offering of such securities
                                           at that time shall be deemed to be the initial bona fide offering thereof.</TD></TR></TABLE>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in">&nbsp;</P>
  
  <TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
  <TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in">(3)</TD><TD>To remove from registration by means of a post-effective
                                           amendment any of the securities being registered which remain unsold at the termination
                                           of the offering.</TD></TR></TABLE>
  
  <P STYLE="margin-top: 0; margin-bottom: 0">&nbsp;</P>
  
  <TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
  <TD STYLE="width: 0"></TD><TD STYLE="width: 0.25in">(b)</TD><TD>The undersigned Registrant hereby undertakes that, for purposes
                                           of determining any liability under the Securities Act, each filing of the Registrant&rsquo;s
                                           annual report pursuant to Section&nbsp;13(a) or Section&nbsp;15(d) of the Exchange Act
                                           (and, where applicable, each filing of an employee benefit plan&rsquo;s annual report
                                           pursuant to Section&nbsp;15(d) of the Exchange Act) that is incorporated by reference
                                           in this registration statement shall be deemed to be a new registration statement, relating
                                           to the securities offered therein, and the offering of such securities at that time shall
                                           be deemed to be the initial bona fide offering thereof.</TD></TR></TABLE>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in">&nbsp;</P>
  
  <TABLE CELLPADDING="0" CELLSPACING="0" STYLE="width: 100%; font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top; text-align: left">
  <TD STYLE="width: 0"></TD><TD STYLE="width: 0.25in; text-align: left">(h)</TD><TD STYLE="text-align: left">Insofar as indemnification for liabilities arising under
  the Securities Act may be permitted to directors, officers and controlling persons of the Registrant pursuant to the foregoing
  provisions, or otherwise, the Registrant has been advised that in the opinion of the SEC such indemnification is against public
  policy as expressed in the Securities Act and is, therefore, unenforceable. In the event that a claim for indemnification against
  such liabilities (other than the payment by the Registrant of expenses incurred or paid by a director, officer or controlling
  person of the Registrant in the successful defense of any action, suit or proceeding) is asserted by such director, officer or
  controlling person in connection with the securities being registered, the Registrant will, unless in the opinion of its counsel
  the matter has been settled by controlling precedent, submit to a court of appropriate jurisdiction the question whether such
  indemnification by it is against public policy as expressed in the Securities Act and will be governed by the final adjudication
  of such issue.</TD>
  </TR></TABLE>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.25in; text-indent: -0.25in">&nbsp;</P>
  
  
  <!-- Field: Page; Sequence: 6; Value: 1 -->
      <DIV STYLE="margin-top: 12pt; margin-bottom: 6pt; border-bottom: Black 1.5pt solid"><P STYLE="text-align: center; margin-top: 0pt; margin-bottom: 0pt">II-<!-- Field: Sequence; Type: Arabic; Name: PageNo -->3<!-- Field: /Sequence --></P></DIV>
      <DIV STYLE="break-before: page; margin-top: 6pt; margin-bottom: 12pt"><P STYLE="margin: 0pt">&nbsp;</P></DIV>
      <!-- Field: /Page -->
  
  <P STYLE="text-align: center; font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center"><B>Signatures</B></P>
  
  <P STYLE="text-align: center; font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: left">Pursuant to the requirements of the
  Securities Act, the registrant certifies that it has reasonable grounds to believe that it meets all of the requirements for
  filing on Form S-8 and has duly caused this registration statement to be signed on its behalf by the undersigned, thereunto
  duly authorized, in the City of Miami, Florida, on February 16, 2021.</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: left">&nbsp;</P>
  
  <TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
  <TR STYLE="vertical-align: bottom">
      <TD>&nbsp;</TD>
      <TD COLSPAN="2" STYLE="padding-left: 10pt; text-indent: -10pt"><FONT STYLE="font-size: 10pt"><B>LONGEVERON Inc.</B></FONT></TD></TR>
  <TR STYLE="vertical-align: bottom">
      <TD>&nbsp;</TD>
      <TD COLSPAN="2">&nbsp;</TD></TR>
  <TR>
      <TD STYLE="width: 60%">&nbsp;</TD>
      <TD STYLE="vertical-align: top; width: 4%"><FONT STYLE="font-size: 10pt">By:</FONT></TD>
      <TD STYLE="vertical-align: bottom; width: 36%; border-bottom: black 1.5pt solid"><FONT STYLE="font-size: 10pt">/s/ Geoff Green</FONT></TD></TR>
  <TR STYLE="vertical-align: bottom">
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD><FONT STYLE="font-size: 10pt">Geoff Green</FONT></TD></TR>
  <TR STYLE="vertical-align: bottom">
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD><FONT STYLE="font-size: 10pt">Chief Executive Officer</FONT></TD></TR>
  </TABLE>
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center">&nbsp;</P>
  
  <P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-transform: uppercase; text-align: center"><A NAME="poa_001"></A>SIGNATURES
  AND POWER OF ATTORNEY</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: left">We, the undersigned officers and directors
  of Longeveron Inc., hereby severally constitute and appoint Geoff Green and James Clavijo, and each of them singly (with full
  power to each of them to act alone), our true and lawful attorneys-in-fact and agents, with full power of substitution and resubstitution
  in each of them for him and in his name, place and stead, and in any and all capacities, to sign any and all amendments (including
  post-effective amendments) to this registration statement (or any other registration statement for the same offering that is to
  be effective upon filing pursuant to Rule 462(b) under the Securities Act of 1933), and to file the same, with all exhibits thereto
  and other documents in connection therewith, with the Securities and Exchange Commission, granting unto said attorneys-in-fact
  and agents, and each of them, full power and authority to do and perform each and every act and thing requisite or necessary to
  be done in and about the premises, as full to all intents and purposes as he might or could do in person, hereby ratifying and
  confirming all that said attorneys-in-fact and agents or any of them, or their or his substitute or substitutes, may lawfully
  do or cause to be done by virtue hereof.</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: left">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: left">Pursuant to the requirements of the Securities
  Act of 1933, this registration statement has been signed by the following persons in the capacities held on the dates indicated.</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: left">&nbsp;</P>
  
  <TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
  <TR STYLE="vertical-align: bottom">
      <TD STYLE="white-space: nowrap; width: 29%; border-bottom: black 1.5pt solid; text-align: center"><FONT STYLE="font-size: 10pt"><B>Signature</B></FONT></TD>
      <TD STYLE="width: 1%">&nbsp;</TD>
      <TD STYLE="width: 54%; border-bottom: black 1.5pt solid; text-align: center"><FONT STYLE="font-size: 10pt"><B>Title</B></FONT></TD>
      <TD STYLE="width: 1%">&nbsp;</TD>
      <TD STYLE="width: 15%; border-bottom: black 1.5pt solid; text-align: center"><FONT STYLE="font-size: 10pt"><B>Date</B></FONT></TD></TR>
  <TR STYLE="vertical-align: bottom">
      <TD STYLE="white-space: nowrap">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD></TR>
  <TR STYLE="vertical-align: bottom">
      <TD STYLE="white-space: nowrap; border-bottom: black 1.5pt solid"><FONT STYLE="font-size: 10pt">/s/ Geoff Green</FONT></TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD></TR>
  <TR>
      <TD STYLE="vertical-align: top"><FONT STYLE="font-size: 10pt">Geoff Green</FONT></TD>
      <TD STYLE="vertical-align: bottom">&nbsp;</TD>
      <TD STYLE="vertical-align: top"><P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Chief Executive Officer</P>
          <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">(principal executive officer)</P></TD>
      <TD STYLE="vertical-align: bottom">&nbsp;</TD>
      <TD STYLE="white-space: nowrap; vertical-align: top; text-align: center"><FONT STYLE="font-size: 10pt">February 16, 2021</FONT></TD></TR>
  <TR>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD></TR>
  <TR>
      <TD STYLE="border-bottom: black 1.5pt solid"><FONT STYLE="font-size: 10pt">/s/ James Clavijo</FONT></TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD></TR>
  <TR>
      <TD STYLE="vertical-align: top"><FONT STYLE="font-size: 10pt">James Clavijo</FONT></TD>
      <TD STYLE="vertical-align: bottom">&nbsp;</TD>
      <TD STYLE="vertical-align: top"><P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Chief Financial Officer</P>
          <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">(principal financial officer and principal accounting
          officer)</P></TD>
      <TD STYLE="vertical-align: bottom">&nbsp;</TD>
      <TD STYLE="white-space: nowrap; vertical-align: top; text-align: center"><FONT STYLE="font-size: 10pt">February 16, 2021</FONT></TD></TR>
  <TR>
      <TD STYLE="vertical-align: top">&nbsp;</TD>
      <TD STYLE="vertical-align: bottom">&nbsp;</TD>
      <TD STYLE="vertical-align: top">&nbsp;</TD>
      <TD STYLE="vertical-align: bottom">&nbsp;</TD>
      <TD STYLE="white-space: nowrap; vertical-align: top">&nbsp;</TD></TR>
  <TR>
      <TD STYLE="vertical-align: top; border-bottom: black 1.5pt solid"><FONT STYLE="font-size: 10pt">/s/ Joshua M. Hare</FONT></TD>
      <TD STYLE="vertical-align: bottom">&nbsp;</TD>
      <TD STYLE="vertical-align: top">&nbsp;</TD>
      <TD STYLE="vertical-align: bottom">&nbsp;</TD>
      <TD STYLE="white-space: nowrap; vertical-align: top">&nbsp;</TD></TR>
  <TR>
      <TD STYLE="vertical-align: top"><FONT STYLE="font-size: 10pt">Joshua M. Hare</FONT></TD>
      <TD STYLE="vertical-align: bottom">&nbsp;</TD>
      <TD STYLE="vertical-align: top"><FONT STYLE="font-size: 10pt">Director</FONT></TD>
      <TD STYLE="vertical-align: bottom">&nbsp;</TD>
      <TD STYLE="white-space: nowrap; vertical-align: top; text-align: center"><FONT STYLE="font-size: 10pt">February 16, 2021</FONT></TD></TR>
  <TR>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD></TR>
  <TR>
      <TD STYLE="border-bottom: black 1.5pt solid"><FONT STYLE="font-size: 10pt">/s/ Donald M. Soffer</FONT></TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD></TR>
  <TR>
      <TD STYLE="vertical-align: top"><FONT STYLE="font-size: 10pt">Donald M. Soffer</FONT></TD>
      <TD STYLE="vertical-align: bottom">&nbsp;</TD>
      <TD STYLE="vertical-align: top"><FONT STYLE="font-size: 10pt">Director</FONT></TD>
      <TD STYLE="vertical-align: bottom">&nbsp;</TD>
      <TD STYLE="white-space: nowrap; vertical-align: top; text-align: center"><FONT STYLE="font-size: 10pt">February 16, 2021</FONT></TD></TR>
  <TR>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD></TR>
  <TR>
      <TD STYLE="border-bottom: black 1.5pt solid"><FONT STYLE="font-size: 10pt">/s/ Neil E. Hare</FONT></TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD></TR>
  <TR>
      <TD STYLE="vertical-align: top"><FONT STYLE="font-size: 10pt">Neil E. Hare</FONT></TD>
      <TD STYLE="vertical-align: bottom">&nbsp;</TD>
      <TD STYLE="vertical-align: top"><FONT STYLE="font-size: 10pt">Director </FONT></TD>
      <TD STYLE="vertical-align: bottom">&nbsp;</TD>
      <TD STYLE="white-space: nowrap; vertical-align: top; text-align: center"><FONT STYLE="font-size: 10pt">February 16, 2021</FONT></TD></TR>
  <TR>
      <TD STYLE="vertical-align: top">&nbsp;</TD>
      <TD STYLE="vertical-align: bottom">&nbsp;</TD>
      <TD STYLE="vertical-align: top">&nbsp;</TD>
      <TD STYLE="vertical-align: bottom">&nbsp;</TD>
      <TD STYLE="white-space: nowrap; vertical-align: top">&nbsp;</TD></TR>
  <TR>
      <TD STYLE="vertical-align: top; border-bottom: black 1.5pt solid"><FONT STYLE="font-size: 10pt">/s/ Rock Soffer</FONT></TD>
      <TD STYLE="vertical-align: bottom">&nbsp;</TD>
      <TD STYLE="vertical-align: top">&nbsp;</TD>
      <TD STYLE="vertical-align: bottom">&nbsp;</TD>
      <TD STYLE="white-space: nowrap; vertical-align: top">&nbsp;</TD></TR>
  <TR>
      <TD><FONT STYLE="font-size: 10pt">Rock Soffer</FONT></TD>
      <TD>&nbsp;</TD>
      <TD><FONT STYLE="font-size: 10pt">Director</FONT></TD>
      <TD>&nbsp;</TD>
      <TD STYLE="text-align: center"><FONT STYLE="font-size: 10pt">February 16, 2021</FONT></TD></TR>
  <TR>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD STYLE="text-align: center">&nbsp;</TD></TR>
  <TR>
      <TD STYLE="vertical-align: top; border-bottom: black 1.5pt solid"><FONT STYLE="font-size: 10pt">/s/ Douglas Losordo</FONT></TD>
      <TD STYLE="vertical-align: bottom">&nbsp;</TD>
      <TD STYLE="vertical-align: top">&nbsp;</TD>
      <TD STYLE="vertical-align: bottom">&nbsp;</TD>
      <TD STYLE="white-space: nowrap; vertical-align: top">&nbsp;</TD></TR>
  <TR>
      <TD><FONT STYLE="font-size: 10pt">Douglas Losordo</FONT></TD>
      <TD>&nbsp;</TD>
      <TD><FONT STYLE="font-size: 10pt">Director</FONT></TD>
      <TD>&nbsp;</TD>
      <TD STYLE="text-align: center"><FONT STYLE="font-size: 10pt">February 16, 2021</FONT></TD></TR>
  <TR>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD STYLE="text-align: center">&nbsp;</TD></TR>
  <TR>
      <TD STYLE="vertical-align: top; border-bottom: black 1.5pt solid"><FONT STYLE="font-size: 10pt">/s/ Erin Borger</FONT></TD>
      <TD STYLE="vertical-align: bottom">&nbsp;</TD>
      <TD STYLE="vertical-align: top">&nbsp;</TD>
      <TD STYLE="vertical-align: bottom">&nbsp;</TD>
      <TD STYLE="white-space: nowrap; vertical-align: top">&nbsp;</TD></TR>
  <TR>
      <TD><FONT STYLE="font-size: 10pt">Erin Borger</FONT></TD>
      <TD>&nbsp;</TD>
      <TD><FONT STYLE="font-size: 10pt">Director</FONT></TD>
      <TD>&nbsp;</TD>
      <TD STYLE="text-align: center"><FONT STYLE="font-size: 10pt">February 16, 2021</FONT></TD></TR>
  <TR>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD STYLE="text-align: center">&nbsp;</TD></TR>
  <TR>
      <TD STYLE="vertical-align: top; border-bottom: black 1.5pt solid"><FONT STYLE="font-size: 10pt">/s/ Cathy Ross</FONT></TD>
      <TD STYLE="vertical-align: bottom">&nbsp;</TD>
      <TD STYLE="vertical-align: top">&nbsp;</TD>
      <TD STYLE="vertical-align: bottom">&nbsp;</TD>
      <TD STYLE="white-space: nowrap; vertical-align: top">&nbsp;</TD></TR>
  <TR>
      <TD><FONT STYLE="font-size: 10pt">Cathy Ross</FONT></TD>
      <TD>&nbsp;</TD>
      <TD><FONT STYLE="font-size: 10pt">Director</FONT></TD>
      <TD>&nbsp;</TD>
      <TD STYLE="text-align: center"><FONT STYLE="font-size: 10pt">February 16, 2021</FONT></TD></TR>
  </TABLE>
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
  
  <P STYLE="text-align: center; font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt">II-4</P>
  
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metadata_documents: [{"type": "S-8", "sequence": "1", "filename": "ea135545-s8_longeveron.htm", "description": "REGISTRATION STATEMENT", "secsgml_size_bytes": 71269}]
metadata_filer: {"company-data": {"conformed-name": "Longeveron Inc.", "cik": "0001721484", "assigned-sic": "2834", "irs-number": "472174146", "state-of-incorporation": "DE", "fiscal-year-end": "1231"}, "filing-values": {"form-type": "S-8", "act": "33", "file-number": "333-253141", "film-number": "21638076"}, "business-address": {"street1": "1951 NW 7TH AVENUE", "street2": "SUITE 520", "city": "MIAMI", "state": "FL", "zip": "33136", "phone": "305-302-7158"}, "mail-address": {"street1": "1951 NW 7TH AVENUE", "street2": "SUITE 520", "city": "MIAMI", "state": "FL", "zip": "33136"}, "former-company": {"former-conformed-name": "LONGEVERON LLC", "date-changed": "20171101"}}
text: As filed with
  the Securities and Exchange Commission on February 16, 2021
  Registration No. 333-
  UNITED STATES
  SECURITIES AND EXCHANGE
  COMMISSION
  Washington, D.C. 20549
  FORM S-8
  REGISTRATION STATEMENT
  UNDER
  THE SECURITIES
  ACT OF 1933
  LONGEVERON INC.
  (Exact name of registrant
  as specified in its charter)
  Delaware
  33-0029027
  (State or other jurisdiction of
  incorporation or organization)
  (I.R.S. employer
  identification number)
  1951 NW 7
  TH
  Avenue,
  Suite 520
  Miami, Florida 33136
  Telephone: (305) 909-0840
  (Address, including zip code, and telephone
  number, including area code, of registrant's principal executive offices)
  2017 Longeveron LLC
  Incentive Plan
  Longeveron Inc. 2021
  Incentive Award Plan
  (Full title of the Plan(s))
  Geoff
  Green
  Chief
  Executive Officer
  Longeveron
  Inc.
  1951 NW 7
  th
  Ave., Suite 520
  Miami, FL 33136
  (305) 909-0840
  (Name, address, including zip code, and
  telephone number, including area code, of agent for service)
  Copies to:
  Jennifer Minter, Esq.
  Brian North, Esq.
  Buchanan Ingersoll &
  Rooney PC
  Union Trust Building
  501 Grant Street, Suite
  200
  Pittsburgh, PA 15219
  (412) 562-8800
  Indicate by check mark whether the registrant is a large accelerated
  filer, an accelerated filer, a nonaccelerated filer, smaller reporting company, or an emerging growth company. See the definitions
  of "large accelerated filer," "accelerated filer," "smaller reporting company," and "emerging
  growth company" in Rule 12b-2 of the Exchange Act.
  Large Accelerated Filer
  ☐
  Accelerated filer
  ☐
  Non-accelerated filer
  ☒
  Smaller reporting company
  ☒
  Emerging growth company
  ☒
  If an emerging growth company, indicate by check mark if the
  registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards
  provided pursuant to Section 7(a)(2)(B) of Securities Act.
  ☐
  CALCULATION OF REGISTRATION FEE
  Title
  of Each Class of Securities to be Registered
  Amount
  to be
  Registered
  (1)
  Proposed Maximum
  Aggregate Offering
  Price
  Per Share
  (2)
  Proposed Maximum
  Aggregate Offering
  Price
  Amount of
  Registration Fee
  Class A Common Stock, $0.001 par value per share
  2,074,402
  (3)
  $
  10.00
  $
  20,744,020
  $
  2,263.17
  (1)
  Pursuant to Rule 416 under the Securities Act of 1933,
  as amended (the "Securities Act"), this registration statement also registers an indeterminate number of additional
  shares that may be issued pursuant to the above-named plans as the result of any future stock dividend, stock split, recapitalization
  or any other similar transaction effected without the receipt of consideration which results in an increase in the number of our
  outstanding shares of common stock.
  (2)
  This estimate is made pursuant to Rule 457 of the Securities
  Act solely for purposes of calculating the registration fee. The computation is based upon the initial public offering price of
  the registrant's Class A Common Stock set forth on the cover page of the registrant's prospectus dated February 12,
  2021 relating to its initial public offering.
  (3)
  The number of shares to be registered under the respective
  plans are as follows: 2017 Longeveron LLC Incentive Plan- 855,247; and Longeveron Inc. 2021 Incentive Award Plan- 1,219,155.
  PART I
  INFORMATION REQUIRED IN THE
  SECTION 10(a) PROSPECTUS
  The documents containing the information specified in Part
  I of Form S-8 will be sent or given to participants as specified by Rule 428(b)(1) of the Securities Act. These documents and
  the documents incorporated by reference into this Registration Statement pursuant to Item 3 of Part II of this registration statement,
  taken together, constitute a prospectus that meets the requirements of Section 10(a) of the Securities Act.
  1
  PART II
  INFORMATION REQUIRED IN THE
  REGISTRATION STATEMENT
  In this registration statement,
  Longeveron Inc. is sometimes referred to as "Registrant," "we," "us" or "our."
  Item
  3. Incorporation of Documents by Reference.
  The Securities and Exchange Commission
  ("SEC") allows us to "incorporate by reference" the information we file with them, which means that we
  can disclose important information to you by referring you to those documents. The information incorporated by reference is considered
  to be part of this registration statement, and later information filed with the SEC will update and supersede this information.
  We hereby incorporate by reference into this registration statement the following documents previously filed with the SEC:
  (a)
  The prospectus filed by the Registrant with the SEC pursuant
      to Rule 424(b) under the Securities Act, on February 12, 2021 relating to the registration statement on Form S-1, as
      amended (Registration No. 333-252234), which contains the Registrant's audited financial statements for the latest
      fiscal year for which such statements have been filed; and
  (b)
  The description of the Registrant's common stock set forth
      in the Registrant's registration statement on Form 8-A (File No. 001-40060), filed by the Registrant
      with the SEC under Section 12(b) of the Securities Exchange Act of 1934, as amended (the "Exchange Act"),
      on February 11, 2021, including any amendments or reports filed for the purpose of updating such description.
  In addition, all documents filed by
  the Registrant pursuant to Section 13(a), 13(c), 14 or 15(d) of the Exchange Act subsequent to the filing of this registration
  statement and prior to the filing of a post-effective amendment which indicates that all securities offered hereby have been sold
  or which de-registers all securities then remaining unsold shall be deemed to be incorporated by reference into this registration
  statement and to be a part hereof from the date of filing such documents, except as to specific sections of such statements as
  set forth therein. Any statement contained in a document incorporated or deemed to be incorporated by reference herein shall be
  deemed to be modified or superseded for purposes of this registration statement to the extent that a statement contained herein
  or in any other subsequently filed document which also is incorporated or deemed to be incorporated by reference herein modifies
  or supersedes such statement. Any statement contained herein shall be deemed to be modified or superseded for purposes of this
  registration statement to the extent that a statement contained in any subsequently filed document which also is incorporated
  or deemed to be incorporated by reference herein modifies or supersedes such statement. Any such statement so modified or superseded
  shall not be deemed, except as so modified or superseded, to constitute a part of this registration statement.
  Under no circumstances shall any information
  furnished under Item 2.02 or 7.01 of Form 8-K be deemed incorporated herein by reference unless such Form 8-K expressly
  provides to the contrary.
  Item 4. Description of Securities.
  Not applicable.
  Item 5. Interests of Named
  Experts and Counsel.
  The validity of the securities
  registered hereby has been passed upon for the Company by Buchanan Ingersoll & Rooney PC ("BIR"), Pittsburgh,
  Pennsylvania. Certain attorneys affiliated with BIR beneficially own an aggregate of 20,000 shares of our Class A Common
  Stock.
  II-
  1
  Item 6. Indemnification of
  Directors and Officers.
  Section 102 of the Delaware General
  Corporation Law ("DGCL") permits a corporation to eliminate the personal liability of directors of a corporation
  to the corporation or its stockholders for monetary damages for a breach of fiduciary duty as a director, except where the
  director breached his duty of loyalty, failed to act in good faith, engaged in intentional misconduct or knowingly violated a
  law, authorized the payment of a dividend or approved a stock repurchase in violation of Delaware corporate law or obtained
  an improper personal benefit. Our certificate of incorporation provides that no director shall be personally liable to us or
  our stockholders for monetary damages for any breach of fiduciary duty as a director, notwithstanding any provision of law
  imposing such liability, except to the extent that the DGCL prohibits the elimination or limitation of liability of directors
  for breaches of fiduciary duty.
  Section 145 of the DGCL provides
  that a corporation has the power to indemnify a director, officer, employee, or agent of the corporation, or a person serving
  at the request of the corporation for another corporation, partnership, joint venture, trust or other enterprise in related capacities
  against expenses (including attorneys' fees), judgments, fines and amounts paid in settlement actually and reasonably incurred
  by the person in connection with an action, suit or proceeding to which he was or is a party or is threatened to be made a party
  to any threatened, ending or completed action, suit or proceeding by reason of such position, if such person acted in good faith
  and in a manner he reasonably believed to be in or not opposed to the best interests of the corporation, and, in any criminal
  action or proceeding, had no reasonable cause to believe his conduct was unlawful, except that, in the case of actions brought
  by or in the right of the corporation, no indemnification shall be made with respect to any claim, issue or matter as to which
  such person shall have been adjudged to be liable to the corporation unless and only to the extent that the Court of Chancery
  or other adjudicating court determines that, despite the adjudication of liability but in view of all of the circumstances of
  the case, such person is fairly and reasonably entitled to indemnity for such expenses which the Court of Chancery or such other
  court shall deem proper.
  Our certificate of incorporation
  provides that we will indemnify each person who was or is a party or threatened to be made a party to any threatened, pending
  or completed action, suit or proceeding (other than an action by or in the right of us) by reason of the fact that he or she is
  or was, or has agreed to become, a director or officer, or is or was serving, or has agreed to serve, at our request as a director,
  officer, partner, employee or trustee of, or in a similar capacity with, another corporation, partnership, joint venture, trust
  or other enterprise (all such persons being referred to as an "Indemnitee"), or by reason of any action alleged to
  have been taken or omitted in such capacity, against all expenses (including attorneys' fees), judgments, fines and amounts
  paid in settlement actually and reasonably incurred in connection with such action, suit or proceeding and any appeal therefrom,
  if such Indemnitee acted in good faith and in a manner he or she reasonably believed to be in, or not opposed to, our best interests,
  and, with respect to any criminal action or proceeding, he or she had no reasonable cause to believe his or her conduct was unlawful.
  Our certificate of incorporation provides that we will indemnify any Indemnitee who was or is a party to an action or suit by
  or in the right of us to procure a judgment in our favor by reason of the fact that the Indemnitee is or was, or has agreed to
  become, a director or officer, or is or was serving, or has agreed to serve, at our request as a director, officer, partner, employee
  or trustee of, or in a similar capacity with, another corporation, partnership, joint venture, trust or other enterprise, or by
  reason of any action alleged to have been taken or omitted in such capacity, against all expenses (including attorneys'
  fees) and, to the extent permitted by law, amounts paid in settlement actually and reasonably incurred in connection with such
  action, suit or proceeding, and any appeal therefrom, if the Indemnitee acted in good faith and in a manner he or she reasonably
  believed to be in, or not opposed to, our best interests, except that no indemnification shall be made with respect to any claim,
  issue or matter as to which such person shall have been adjudged to be liable to us, unless a court determines that, despite such
  adjudication but in view of all of the circumstances, he or she is entitled to indemnification of such expenses. Notwithstanding
  the foregoing, to the extent that any Indemnitee has been successful, on the merits or otherwise, he or she will be indemnified
  by us against all expenses (including attorneys' fees) actually and reasonably incurred in connection therewith. Expenses
  must be advanced to an Indemnitee under certain circumstances.
  We have entered into indemnification
  agreements with each of our directors and officers. These indemnification agreements may require us, among other things, to indemnify
  our directors and officers for some expenses, including attorneys' fees, judgments, fines and settlement amounts incurred
  by a director or officer in any action or proceeding arising out of his or her service as one of our directors or officers, or
  any of our subsidiaries or any other company or enterprise to which the person provides services at our request.
  We maintain a general liability
  insurance policy that covers certain liabilities of directors and officers of our corporation arising out of claims based on acts
  or omissions in their capacities as directors or officers.
  Item 7. Exemption from Registration
  Claimed.
  Not applicable.
  II-
  2
  Item
  8. Exhibits.
  Exhibit
  Number
  Exhibit Description
  Incorporated by
      Reference
  Filed
  Herewith
  Form
  File No.
  Exhibit
  Filing
  Date
  4.1
  Certificate of Incorporation of Longeveron Inc.
  X
  4.2
  Bylaws of Longeveron Inc.
  X
  4.3
  Specimen Class A Common Stock Certificate evidencing the shares of Class A common stock
  S-1/A
  333-252234
  4.1
  02/03/2021
  5.1
  Opinion of Buchanan Ingersoll & Rooney PC
  X
  10.1
  2017 Longeveron LLC Incentive Plan
  S-1/A
  333-252234
  10.12
  02/03/2021
  10.2
  Longeveron Inc. 2021 Incentive Award Plan
  S-1/A
  333-252234
  10.13
  02/03/2021
  23.1
  Consent of Independent Registered Public Accounting Firm
  X
  23.2
  Consent of Buchanan Ingersoll & Rooney PC (included in Exhibit 5.1 hereto)
  X
  24.1
  Power of Attorney (see signature page)
  X
  Item 9. Undertakings.
  (a)
  The undersigned Registrant hereby undertakes:
  (1)
  To file, during any period in which offers or sales are being
                                           made, a post-effective amendment to this registration statement,
  (i)
  to include any prospectus required by Section 10(a)(3)
                                           of the Securities Act;
  (ii)
  to reflect in the prospectus any facts or events arising after
                                           the effective date of this registration statement (or the most recent post-effective
                                           amendment thereof) which, individually or in the aggregate, represent a fundamental change
                                           in the information set forth in this registration statement. Notwithstanding the foregoing,
                                           any increase or decrease in volume of securities offered (if the total dollar value of
                                           securities offered would not exceed that which was registered) and any deviation from
                                           the low or high end of the estimated maximum offering range may be reflected in the form
                                           of prospectus filed with the SEC pursuant to Rule 424(b) if, in the aggregate, the changes
                                           in volume and price represent no more than 20% change in the maximum aggregate offering
                                           price set forth in the "Calculation of Registration Fee" table in the effective
                                           registration statement; and
  (iii)
  to include any material information with respect to the plan
                                           of distribution not previously disclosed in this registration statement or any material
                                           change to such information in this registration statement;
  provided, however
  , that paragraphs (a)(1)(i) and (a)(1)(ii)
  do not apply if this registration statement is on Form S-8 and the information required to be included in a post-effective
  amendment by those paragraphs is contained in reports filed with or furnished to the SEC by the Registrant pursuant to Section 13
  or Section 15(d) of the Exchange Act that are incorporated by reference in this registration statement.
  (2)
  That, for the purpose of determining any liability under
                                           the Securities Act, each such post-effective amendment shall be deemed to be a new registration
                                           statement relating to the securities offered therein, and the offering of such securities
                                           at that time shall be deemed to be the initial bona fide offering thereof.
  (3)
  To remove from registration by means of a post-effective
                                           amendment any of the securities being registered which remain unsold at the termination
                                           of the offering.
  (b)
  The undersigned Registrant hereby undertakes that, for purposes
                                           of determining any liability under the Securities Act, each filing of the Registrant's
                                           annual report pursuant to Section 13(a) or Section 15(d) of the Exchange Act
                                           (and, where applicable, each filing of an employee benefit plan's annual report
                                           pursuant to Section 15(d) of the Exchange Act) that is incorporated by reference
                                           in this registration statement shall be deemed to be a new registration statement, relating
                                           to the securities offered therein, and the offering of such securities at that time shall
                                           be deemed to be the initial bona fide offering thereof.
  (h)
  Insofar as indemnification for liabilities arising under
  the Securities Act may be permitted to directors, officers and controlling persons of the Registrant pursuant to the foregoing
  provisions, or otherwise, the Registrant has been advised that in the opinion of the SEC such indemnification is against public
  policy as expressed in the Securities Act and is, therefore, unenforceable. In the event that a claim for indemnification against
  such liabilities (other than the payment by the Registrant of expenses incurred or paid by a director, officer or controlling
  person of the Registrant in the successful defense of any action, suit or proceeding) is asserted by such director, officer or
  controlling person in connection with the securities being registered, the Registrant will, unless in the opinion of its counsel
  the matter has been settled by controlling precedent, submit to a court of appropriate jurisdiction the question whether such
  indemnification by it is against public policy as expressed in the Securities Act and will be governed by the final adjudication
  of such issue.
  II-
  3
  Signatures
  Pursuant to the requirements of the
  Securities Act, the registrant certifies that it has reasonable grounds to believe that it meets all of the requirements for
  filing on Form S-8 and has duly caused this registration statement to be signed on its behalf by the undersigned, thereunto
  duly authorized, in the City of Miami, Florida, on February 16, 2021.
  LONGEVERON Inc.
  By:
  /s/ Geoff Green
  Geoff Green
  Chief Executive Officer
  SIGNATURES
  AND POWER OF ATTORNEY
  We, the undersigned officers and directors
  of Longeveron Inc., hereby severally constitute and appoint Geoff Green and James Clavijo, and each of them singly (with full
  power to each of them to act alone), our true and lawful attorneys-in-fact and agents, with full power of substitution and resubstitution
  in each of them for him and in his name, place and stead, and in any and all capacities, to sign any and all amendments (including
  post-effective amendments) to this registration statement (or any other registration statement for the same offering that is to
  be effective upon filing pursuant to Rule 462(b) under the Securities Act of 1933), and to file the same, with all exhibits thereto
  and other documents in connection therewith, with the Securities and Exchange Commission, granting unto said attorneys-in-fact
  and agents, and each of them, full power and authority to do and perform each and every act and thing requisite or necessary to
  be done in and about the premises, as full to all intents and purposes as he might or could do in person, hereby ratifying and
  confirming all that said attorneys-in-fact and agents or any of them, or their or his substitute or substitutes, may lawfully
  do or cause to be done by virtue hereof.
  Pursuant to the requirements of the Securities
  Act of 1933, this registration statement has been signed by the following persons in the capacities held on the dates indicated.
  Signature
  Title
  Date
  /s/ Geoff Green
  Geoff Green
  Chief Executive Officer
  (principal executive officer)
  February 16, 2021
  /s/ James Clavijo
  James Clavijo
  Chief Financial Officer
  (principal financial officer and principal accounting
          officer)
  February 16, 2021
  /s/ Joshua M. Hare
  Joshua M. Hare
  Director
  February 16, 2021
  /s/ Donald M. Soffer
  Donald M. Soffer
  Director
  February 16, 2021
  /s/ Neil E. Hare
  Neil E. Hare
  Director
  February 16, 2021
  /s/ Rock Soffer
  Rock Soffer
  Director
  February 16, 2021
  /s/ Douglas Losordo
  Douglas Losordo
  Director
  February 16, 2021
  /s/ Erin Borger
  Erin Borger
  Director
  February 16, 2021
  /s/ Cathy Ross
  Cathy Ross
  Director
  February 16, 2021
  II-4