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  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>As filed with the Securities and Exchange
  Commission on April 12, 2019</B></P>
  
  
  
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  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: right">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: right"><B>Registration No. 333-</B>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</P>
  
  
  
  
  
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  <!-- Field: Rule-Page --><DIV ALIGN="LEFT" STYLE="margin-top: 0; margin-bottom: 0"><DIV STYLE="font-size: 1pt; border-top: Black 2pt solid; border-bottom: Black 1pt solid; width: 100%">&nbsp;</DIV></DIV><!-- Field: /Rule-Page -->
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>&nbsp;</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center"><B>UNITED STATES</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center"><B>SECURITIES AND EXCHANGE COMMISSION</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center"><B>WASHINGTON, D.C. 20549</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; text-align: center; margin-bottom: 0pt">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center"><B>FORM S-8</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center"><B>REGISTRATION STATEMENT</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center"><B>UNDER</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center"><B>THE SECURITIES ACT OF 1933</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; text-align: center; margin-bottom: 0pt">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center"><B>ICAGEN, INC.</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center"><I>(Exact name of registrant as specified
  in its charter)</I></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; text-align: center; margin-bottom: 0pt">&nbsp;</P>
  
  <TABLE CELLSPACING="0" CELLPADDING="0" STYLE="width: 100%; font: 10pt Times New Roman, Times, Serif">
  <TR>
      <TD STYLE="text-align: center; font-size: 10pt; width: 49%; border-bottom: Black 1.5pt solid"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt"><B>Delaware</B></FONT></TD>
      <TD STYLE="width: 2%; padding-bottom: 1.5pt">&nbsp;</TD>
      <TD STYLE="text-align: center; font-size: 10pt; width: 49%; border-bottom: Black 1.5pt solid"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt"><B>20-0982060</B></FONT></TD></TR>
  <TR>
      <TD STYLE="text-align: center">
          <P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center"><I>(State
  or other jurisdiction of <BR>
  incorporation or organization)</I></P></TD>
      <TD>&nbsp;</TD>
      <TD STYLE="text-align: center">
          <P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center"><I>(I.R.S. Employer</I></P>
          <P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center"><I>Identification Number)</I></P></TD></TR>
  </TABLE>
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; text-align: center; margin-bottom: 0pt">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center"><B>4222 Emperor Blvd., Suite 350</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center"><B>Research Triangle Park</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center"><B>Durham, North Carolina 27703</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center"><B>(919) 941-5206</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center"><I>(Address, including ZIP code, and telephone
  number, including</I></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center"><I>area code, of registrant&rsquo;s principal
  executive office)</I></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>ICAGEN, INC. 2018 STOCK INCENTIVE PLAN</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><I>(Full title of the Plan)</I></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>Richard Cunningham</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>Chief Executive Officer </B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>Icagen, Inc.</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 2.8pt 0pt 0; text-align: center"><B>4222 Emperor Blvd., Suite 350</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 2.8pt 0pt 0; text-align: center"><B>Research Triangle Park</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0.8pt 0pt 0; text-align: center"><B>Durham, North Carolina 27703</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>(919) 941-5206</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><I>(Name, address and telephone number of
  agent of services)</I></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B><I>WITH COPIES TO:</I></B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>Leslie Marlow, Esq.</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>Hank Gracin, Esq</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>Patrick J. Egan, Esq.</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>Gracin &amp; Marlow, LLP</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>The Chrysler Building</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>405 Lexington Avenue, 26<SUP>th</SUP>
  Floor</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>New York, New York 10174</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>(212) 907-6457</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><I>(Name, address and telephone number)</I></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">Indicate by check mark whether the registrant
  is a large accelerated filer, an accelerated filer, a non-accelerated filer, a smaller reporting company or an emerging growth
  company. See the definitions of &ldquo;large accelerated filer,&rdquo; &ldquo;accelerated filer&rdquo; &ldquo;smaller reporting
  company&rdquo; and &ldquo;emerging growth company&rdquo; in Rule 12b-2 of the Exchange Act:</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
  
  <TABLE CELLSPACING="0" CELLPADDING="0" STYLE="width: 100%; font: 10pt Times New Roman, Times, Serif">
  <TR STYLE="vertical-align: top">
      <TD STYLE="font-size: 10pt; width: 64%"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">Large accelerated filer &nbsp;&nbsp;</FONT>&#9744;</TD>
      <TD STYLE="font-size: 10pt; width: 36%"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">Accelerated filer &nbsp;&nbsp;</FONT>&#9744;</TD></TR>
  <TR STYLE="vertical-align: top">
      <TD STYLE="font-size: 10pt"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">Non-accelerated filer
  &nbsp;&nbsp;&nbsp;&nbsp;</FONT><FONT STYLE="font-family: Wingdings; font-size: 10pt">&thorn;</FONT></TD>
      <TD STYLE="font-size: 10pt"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">Smaller reporting company &nbsp;</FONT><FONT STYLE="font-family: Wingdings; font-size: 10pt">&thorn;</FONT></TD></TR>
  <TR STYLE="vertical-align: top">
      <TD STYLE="text-align: justify; font-size: 10pt">&nbsp;</TD>
      <TD STYLE="text-align: justify; font-size: 10pt"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">Emerging growth company &nbsp;</FONT>&#9744;</TD></TR>
  </TABLE>
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><FONT STYLE="font-family: Times New Roman, Times, Serif">If
  an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for
  complying with any new or revised financial accounting standards provided pursuant to Section 13(a) of the Exchange Act.&nbsp;&nbsp;</FONT><FONT STYLE="font-family: Wingdings">&uml;</FONT></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;&nbsp;</P>
  
  
  
  
  
  
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  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B>&nbsp;</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center"><B>CALCULATION OF REGISTRATION FEE</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>
  
  <TABLE CELLPADDING="0" CELLSPACING="0" STYLE="border-collapse: collapse; width: 100%; font: 10pt Times New Roman, Times, Serif">
  <TR STYLE="vertical-align: bottom">
      <TD STYLE="font-weight: bold; border-bottom: Black 1.5pt solid; padding-right: 0; padding-left: 0; text-indent: 0">Title&nbsp;of Securities to be Registered</TD><TD STYLE="padding-bottom: 1.5pt; padding-right: 0; padding-left: 0; text-indent: 0">&nbsp;</TD>
      <TD STYLE="text-align: center; border-bottom: Black 1.5pt solid; padding-right: 0; padding-left: 0; text-indent: 0"><P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>Amount&nbsp;to&nbsp;be</B></P> <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>Registered</B></P> <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>(1)(2)</B></P></TD><TD STYLE="padding-bottom: 1.5pt; padding-right: 0; padding-left: 0; text-indent: 0">&nbsp;</TD>
      <TD COLSPAN="2" STYLE="text-align: center; border-bottom: Black 1.5pt solid; padding-right: 0; padding-left: 0; text-indent: 0"><P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>Proposed&nbsp;Maximum</B></P> <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>Offering Price</B></P> <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>Per<BR>
  Share(3)</B></P></TD><TD STYLE="padding-bottom: 1.5pt; padding-right: 0; padding-left: 0; text-indent: 0">&nbsp;</TD><TD STYLE="padding-bottom: 1.5pt; padding-right: 0; padding-left: 0; text-indent: 0">&nbsp;</TD>
      <TD COLSPAN="2" STYLE="text-align: center; border-bottom: Black 1.5pt solid; padding-right: 0; padding-left: 0; text-indent: 0"><P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>Proposed Maximum</B></P> <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>Aggregate</B></P> <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>Offering<BR>
  Price(3)</B></P></TD><TD STYLE="padding-bottom: 1.5pt; padding-right: 0; padding-left: 0; text-indent: 0">&nbsp;</TD><TD STYLE="padding-bottom: 1.5pt; padding-right: 0; padding-left: 0; text-indent: 0">&nbsp;</TD>
      <TD COLSPAN="2" STYLE="text-align: center; border-bottom: Black 1.5pt solid; padding-right: 0; padding-left: 0; text-indent: 0"><P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>Amount&nbsp;of</B></P> <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>Registration<BR>
  Fee(4)</B></P></TD><TD STYLE="padding-bottom: 1.5pt; padding-right: 0; padding-left: 0; text-indent: 0">&nbsp;</TD></TR>
  <TR STYLE="vertical-align: bottom; background-color: White">
      <TD STYLE="width: 52%; padding-right: 0; padding-left: 0; text-indent: 0">&nbsp;</TD><TD STYLE="width: 1%; padding-right: 0; padding-left: 0; text-indent: 0">&nbsp;</TD>
      <TD STYLE="width: 11%; padding-right: 0; padding-left: 0; text-indent: 0">&nbsp;</TD><TD STYLE="width: 1%; padding-right: 0; padding-left: 0; text-indent: 0">&nbsp;</TD>
      <TD STYLE="width: 1%; text-align: left; padding-right: 0; padding-left: 0; text-indent: 0">&nbsp;</TD><TD STYLE="width: 9%; text-align: right; padding-right: 0; padding-left: 0; text-indent: 0">&nbsp;</TD><TD STYLE="width: 1%; text-align: left; padding-right: 0; padding-left: 0; text-indent: 0">&nbsp;</TD><TD STYLE="width: 1%; padding-right: 0; padding-left: 0; text-indent: 0">&nbsp;</TD>
      <TD STYLE="width: 1%; text-align: left; padding-right: 0; padding-left: 0; text-indent: 0">&nbsp;</TD><TD STYLE="width: 9%; text-align: right; padding-right: 0; padding-left: 0; text-indent: 0">&nbsp;</TD><TD STYLE="width: 1%; text-align: left; padding-right: 0; padding-left: 0; text-indent: 0">&nbsp;</TD><TD STYLE="width: 1%; padding-right: 0; padding-left: 0; text-indent: 0">&nbsp;</TD>
      <TD STYLE="width: 1%; text-align: left; padding-right: 0; padding-left: 0; text-indent: 0">&nbsp;</TD><TD STYLE="width: 9%; text-align: right; padding-right: 0; padding-left: 0; text-indent: 0">&nbsp;</TD><TD STYLE="width: 1%; text-align: left; padding-right: 0; padding-left: 0; text-indent: 0">&nbsp;</TD></TR>
  <TR STYLE="vertical-align: bottom; background-color: rgb(204,238,255)">
      <TD STYLE="text-align: left; padding-right: 0; padding-left: 0.125in; text-indent: -0.125in">Common Stock, par &nbsp;&nbsp;value $0.001 per share, under the 2018 Stock Incentive Plan</TD><TD STYLE="padding-right: 0; padding-left: 0; text-indent: 0">&nbsp;</TD>
      <TD STYLE="text-align: center; padding-right: 0; padding-left: 0; text-indent: 0">2,000,000 shares</TD><TD STYLE="padding-right: 0; padding-left: 0; text-indent: 0">&nbsp;</TD>
      <TD STYLE="text-align: left; padding-right: 0; padding-left: 0; text-indent: 0">$</TD><TD STYLE="text-align: right; padding-right: 0; padding-left: 0; text-indent: 0">3.50</TD><TD STYLE="text-align: left; padding-right: 0; padding-left: 0; text-indent: 0">&nbsp;</TD><TD STYLE="padding-right: 0; padding-left: 0; text-indent: 0">&nbsp;</TD>
      <TD STYLE="text-align: left; padding-right: 0; padding-left: 0; text-indent: 0">$</TD><TD STYLE="text-align: right; padding-right: 0; padding-left: 0; text-indent: 0">7,000,000</TD><TD STYLE="text-align: left; padding-right: 0; padding-left: 0; text-indent: 0">&nbsp;</TD><TD STYLE="padding-right: 0; padding-left: 0; text-indent: 0">&nbsp;</TD>
      <TD STYLE="text-align: left; padding-right: 0; padding-left: 0; text-indent: 0">$</TD><TD STYLE="text-align: right; padding-right: 0; padding-left: 0; text-indent: 0">848.40</TD><TD STYLE="text-align: left; padding-right: 0; padding-left: 0; text-indent: 0">&nbsp;</TD></TR>
  </TABLE>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.25in; text-align: justify; text-indent: -0.25in">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.25in; text-align: justify; text-indent: -0.25in"></P>
  
  <!-- Field: Rule-Page --><DIV ALIGN="LEFT" STYLE="margin-top: 0; margin-bottom: 0"><DIV STYLE="font-size: 1pt; border-top: Black 1.5pt solid; width: 25%">&nbsp;</DIV></DIV><!-- Field: /Rule-Page -->
  
  <TABLE CELLPADDING="0" CELLSPACING="0" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 0; width: 100%"><TR STYLE="vertical-align: top; text-align: justify">
  <TD STYLE="width: 0"></TD><TD STYLE="width: 0.25in; text-align: left">(1)</TD><TD STYLE="text-align: justify">The securities to be registered include options and other
  rights to acquire the common stock of Icagen, Inc. (the &ldquo;Registrant&rdquo;).</TD>
  </TR></TABLE>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.25in; text-align: justify; text-indent: -0.25in">&nbsp;</P>
  
  <TABLE CELLPADDING="0" CELLSPACING="0" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 0; width: 100%"><TR STYLE="vertical-align: top; text-align: justify">
  <TD STYLE="width: 0"></TD><TD STYLE="width: 0.25in; text-align: left">(2)</TD><TD STYLE="text-align: justify">Pursuant to Rule 416(a) under the Securities Act of 1933,
  as amended (the &ldquo;Securities Act&rdquo;), this registration statement also covers any additional securities that may be offered
  or issued in connection with any stock split, stock dividend or similar transaction.</TD>
  </TR></TABLE>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.25in; text-align: justify; text-indent: -0.25in">&nbsp;</P>
  
  <TABLE CELLPADDING="0" CELLSPACING="0" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 0; width: 100%"><TR STYLE="vertical-align: top; text-align: justify">
  <TD STYLE="width: 0"></TD><TD STYLE="width: 0.25in; text-align: left">(3)</TD><TD STYLE="text-align: justify">Estimated solely for the purpose of calculating the registration
  fee pursuant to Rule 457(h) under the Securities Act.</TD>
  </TR></TABLE>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.25in; text-align: justify; text-indent: -0.25in">&nbsp;</P>
  
  <TABLE CELLPADDING="0" CELLSPACING="0" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 0; width: 100%"><TR STYLE="vertical-align: top; text-align: justify">
  <TD STYLE="width: 0; text-align: justify"></TD><TD STYLE="width: 0.25in; text-align: justify">(4)</TD><TD STYLE="text-align: justify">Calculated under Section 6(b) of the Securities Act as
  ..00012120 of the proposed maximum aggregate offering price.</TD>
  </TR></TABLE>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
  
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  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
  
  
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  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center"><B>EXPLANATORY NOTE</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.5in">Icagen, Inc. (the &ldquo;Registrant&rdquo;
  or the &ldquo;Company&rdquo;) hereby files this Registration Statement on Form S-8 relating to its common stock, par value $0.001
  per share (the &ldquo;Common Stock&rdquo;), which have been reserved for issuance and are issuable pursuant to the Company&rsquo;s
  2018 Stock Incentive Plan (hereinafter referred to as the &ldquo;Plan&rdquo;).</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center"></P>
  
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      <DIV STYLE="page-break-before: always; margin-top: 6pt; margin-bottom: 12pt"><P STYLE="margin: 0pt">&nbsp;</P></DIV>
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  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center"><B>PART I</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center"><B>INFORMATION REQUIRED IN THE SECTION 10(a)
  PROSPECTUS</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B>Item&nbsp;1. Plan Information.* </B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B>Item&nbsp;2. Registrant Information and Employee Plan Annual
  Information.* </B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.5in">*The information specified
  in Item 1 and Item 2 of Part I of this Registration Statement on Form S-8 is omitted from this filing in accordance with the provisions
  of Rule 428 under the Securities Act of 1933, as amended (the &ldquo;Securities Act&rdquo;), and the introductory note to Part
  I of Form S-8. The documents containing the information specified in Part I will be delivered to the participants in the Plan as
  required by Rule 428. Such documents and the documents incorporated by reference in this Registration Statement pursuant to Item
  3 of Part II of this Registration Statement, taken together, constitute a prospectus that meets the requirements of Section 10(a)
  of the Securities Act.</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center"></P>
  
  <!-- Field: Page; Sequence: 4; Options: NewSection; Value: 1 -->
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      <!-- Field: /Page -->
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center"><B>PART II</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center"><B>INFORMATION REQUIRED IN THE REGISTRATION
  STATEMENT</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B>Item 3. Incorporation of Documents by Reference.</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.5in">The Securities and
  Exchange Commission (the &ldquo;SEC&rdquo;) allows us to &ldquo;incorporate by reference&rdquo; the information we file with it
  which means that we can disclose important information to you by referring you to those documents instead of having to repeat the
  information in this prospectus. The information incorporated by reference is considered to be part of this prospectus, and later
  information that we file with the SEC will automatically update and supersede this information. We incorporate by reference the
  documents listed below and any future filings made with the SEC under Sections&nbsp;13(a), 13(c), 14 or 15(d) of the Securities
  Exchange Act of 1934, as amended (the &ldquo;Exchange Act&rdquo;), between the date of this prospectus and the termination of the
  offering:</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.5in">&nbsp;</P>
  
  <TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
  <TR STYLE="vertical-align: top">
      <TD STYLE="width: 0.5in; text-align: justify">&nbsp;</TD>
      <TD STYLE="width: 0.25in; text-align: justify">&#9679;</TD>
      <TD STYLE="text-align: justify"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">Our Annual Report on Form 10-K for the year ended December 31, 2018 (File No. 000-54748) filed with the SEC on April 12, 2019;</FONT></TD></TR>
  <TR STYLE="vertical-align: top">
      <TD STYLE="text-align: justify">&nbsp;</TD>
      <TD STYLE="text-align: justify">&#9679;</TD>
      <TD STYLE="text-align: justify"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">Our Definitive Information Statement on Schedule 14C filed on December 31, 2018; and</FONT></TD></TR>
  <TR STYLE="vertical-align: top">
      <TD STYLE="text-align: justify">&nbsp;</TD>
      <TD STYLE="text-align: justify">&#9679;</TD>
      <TD STYLE="text-align: justify"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">The description of our common stock set forth in our registration statement on Form&nbsp;8-A, filed with the SEC on June 28, 2012 (File No. 000-54748).</FONT></TD></TR>
  </TABLE>
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.5in">All reports and other
  documents subsequently filed by the Company pursuant to Sections&nbsp;13(a), 13(c), 14 or 15(d) of the Exchange Act shall be deemed
  to be incorporated by reference in this Registration Statement and to be a part of this Registration Statement from the respective
  date of filing of each of those reports or documents until the filing of a post-effective amendment to this Registration Statement
  which indicates either that all securities offered by this Registration Statement have been sold or which deregisters all of the
  securities under this Registration Statement then remaining unsold.</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.5in">&nbsp;</P>
  
  
  <!-- Field: Page; Sequence: 5; Options: NewSection; Value: 1 -->
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  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.5in">Any statement contained
  in this Registration Statement or in a document incorporated or deemed to be incorporated by reference in this Registration Statement
  shall be deemed to be modified or superseded for purposes of this Registration Statement to the extent that a statement contained
  in this Registration Statement or in any other subsequently filed document which also is or is deemed to be incorporated by reference
  in this Registration Statement modifies or supersedes that statement. Any statement so modified or superseded shall not be deemed,
  except as so modified or superseded, to constitute a part of this Registration Statement.</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&nbsp;&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B>Item 4. Description of Securities.</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">Not applicable.</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&nbsp;&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B>Item 5. Interests of Named Experts and Counsel.</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">As of the date of this Registration Statement, an attorney of Gracin&nbsp;&amp; Marlow, LLP beneficially owns
  securities exercisable to purchase an aggregate of 25,000 shares of the Registrant&rsquo;s capital stock.</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&nbsp;&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B>Item 6. Indemnification of Directors and Officers.</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.5in">Section&nbsp;145 of
  the Delaware General Corporation Law (the &ldquo;DGCL&rdquo;) provides that a corporation may indemnify directors and officers
  as well as other employees and individuals against expenses (including attorneys&rsquo; fees), judgments, fines and amounts paid
  in settlement actually and reasonably incurred by such person in connection with any threatened, pending or completed actions,
  suits or proceedings in which such person is made a party by reason of such person being or having been a director, officer, employee
  or agent of the Registrant. The DGCL provides that Section&nbsp;145 is not exclusive of other rights to which those seeking indemnification
  may be entitled under any bylaws, agreement, vote of stockholders or disinterested directors or otherwise. The Registrant&rsquo;s
  Second Amended and Restated Certificate of Incorporation, as amended, and Amended and Restated Bylaws provide for indemnification
  by the Registrant of its directors and officers to the fullest extent permitted by the DGCL.</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.5in">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.5in">Section&nbsp;102(b)(7)
  of the DGCL permits a corporation to provide in its certificate of incorporation that a director of the corporation shall not be
  personally liable to the corporation or its stockholders for monetary damages for breach of fiduciary duty as a director, except
  for liability (1)&nbsp;for any breach of the director&rsquo;s duty of loyalty to the corporation or its stockholders, (2)&nbsp;for
  acts or omissions not in good faith or which involve intentional misconduct or a knowing violation of law, (3)&nbsp;for unlawful
  payments of dividends or unlawful stock repurchases, redemptions or other distributions or (4)&nbsp;for any transaction from which
  the director derived an improper personal benefit. The Registrant&rsquo;s Second Amended and Restated Certificate of Incorporation,
  as amended, provides for such limitation of liability to the fullest extent permitted by the DGCL.</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.5in">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.5in">The Registrant maintains
  standard policies of insurance under which coverage is provided (1)&nbsp;to its directors and officers against loss rising from
  claims made by reason of breach of duty or other wrongful act, while acting in their capacity as directors and officers of the
  Registrant, and (2)&nbsp;to the Registrant with respect to payments which may be made by the Registrant to such officers and directors
  pursuant to any indemnification provisions contained in the Registrant&rsquo;s Second Amended and Restated Certificate of Incorporation,
  as amended, and Amended and Restated Bylaws or otherwise as a matter of law.</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B>&nbsp;</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B>Item&nbsp;7. Exemption from Registration Claimed. </B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">Not applicable.</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
  
  
  <!-- Field: Page; Sequence: 6; Value: 1 -->
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  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B>Item 8. Exhibits.</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;&nbsp;</P>
  
  <TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
  <TR STYLE="vertical-align: top">
      <TD STYLE="width: 10%; text-align: center; border-bottom: Black 1.5pt solid"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt"><B>Exhibit&nbsp;No.</B></FONT></TD>
      <TD STYLE="width: 1%; padding-bottom: 1.5pt">&nbsp;</TD>
      <TD STYLE="width: 89%; border-bottom: Black 1.5pt solid"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt"><B>Description&nbsp;of&nbsp;Document</B></FONT></TD></TR>
  <TR STYLE="vertical-align: top; background-color: rgb(204,238,255)">
      <TD STYLE="padding-right: 0.8pt; text-align: center"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">4.1</FONT></TD>
      <TD STYLE="padding-right: 0.8pt">&nbsp;</TD>
      <TD STYLE="padding-right: 0.8pt; text-align: justify"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt"><A HREF="http://www.sec.gov/Archives/edgar/data/1518520/000121390012001987/fs1a1ex3v_caldera.htm">Second Amended and Restated Certificate of Incorporation dated April 10, 2012 (Incorporated by reference to the Registration Statement on Form S-1/A filed April 20, 2012, File No. 333-179508)</A></FONT></TD></TR>
  <TR STYLE="vertical-align: top; background-color: White">
      <TD STYLE="padding-right: 0.8pt; text-align: center"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">4.2</FONT></TD>
      <TD STYLE="padding-right: 0.8pt">&nbsp;</TD>
      <TD STYLE="padding-right: 0.8pt; text-align: justify"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt"><A HREF="http://www.sec.gov/Archives/edgar/data/1518520/000121390014008757/f8k120214ex3i_calderapharm.htm">Certificate of Amendment to the Second Amended and Restated Certificate of Incorporation (Incorporated by reference to the Current Report on Form 8-K filed on December 5, 2014, File No. 000-54748)</A></FONT></TD></TR>
  <TR STYLE="vertical-align: top; background-color: rgb(204,238,255)">
      <TD STYLE="padding-right: 0.8pt; text-align: center"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">4.3</FONT></TD>
      <TD STYLE="padding-right: 0.8pt">&nbsp;</TD>
      <TD STYLE="padding-right: 0.8pt; text-align: justify"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt"><A HREF="http://www.sec.gov/Archives/edgar/data/1518520/000121390015001344/f8k022015ex3i_xrprosciences.htm">Amended and Restated Bylaws (Incorporated by reference to the Current Report on Form 8-K filed on February 25, 2015, File No. 000-54748)</A></FONT></TD></TR>
  <TR STYLE="vertical-align: top; background-color: White">
      <TD STYLE="padding-right: 0.8pt; text-align: center"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">4.4</FONT></TD>
      <TD STYLE="padding-right: 0.8pt">&nbsp;</TD>
      <TD STYLE="padding-right: 0.8pt; text-align: justify"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt"><A HREF="http://www.sec.gov/Archives/edgar/data/1518520/000121390015002106/f8k032415ex3i_xrpro.htm">Certificate of Amendment to Second Amended and Restated Certificate of Incorporation (Incorporated by reference to the Current Report on Form 8-K filed March 26, 2015, File No. 000-54748)</A></FONT></TD></TR>
  <TR STYLE="vertical-align: top; background-color: rgb(204,238,255)">
      <TD STYLE="padding-right: 0.8pt; text-align: center"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">4.5</FONT></TD>
      <TD STYLE="padding-right: 0.8pt">&nbsp;</TD>
      <TD STYLE="padding-right: 0.8pt; text-align: justify"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt"><A HREF="http://www.sec.gov/Archives/edgar/data/1518520/000121390015006651/f8k082815ex3i_icageninc.htm">Certificate of Amendment to the Second Amended and Restated Certificate of Incorporation (Incorporated by reference to the Current Report on Form 8-K filed August 31, 2015, File No. 000-54748)</A></FONT></TD></TR>
  <TR STYLE="vertical-align: top; background-color: White">
      <TD STYLE="padding-right: 0.8pt; text-align: center"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">4.6</FONT></TD>
      <TD STYLE="padding-right: 0.8pt">&nbsp;</TD>
      <TD STYLE="padding-right: 0.8pt; text-align: justify"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt"><A HREF="http://www.sec.gov/Archives/edgar/data/1518520/000121390018018007/def14c1218_icageninc.htm#annex_b">Icagen, Inc. 2018 Stock Incentive Plan (Incorporated by reference to Exhibit B to the Definitive Information Statement on Schedule 14C filed with the Securities and Exchange Commission on December 31, 2018)</A></FONT></TD></TR>
  <TR STYLE="vertical-align: top; background-color: rgb(204,238,255)">
      <TD STYLE="padding-right: 0.8pt; text-align: center"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">4.7</FONT></TD>
      <TD STYLE="padding-right: 0.8pt">&nbsp;</TD>
      <TD STYLE="padding-right: 0.8pt; text-align: justify"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt"><A HREF="http://www.sec.gov/Archives/edgar/data/1518520/000121390019006256/f10k2018ex4-24_icagen.htm">Icagen, Inc. Form of Stock Option Agreement under the 2018 Stock Incentive Plan (Incorporated by reference to the Annual Report on Form 10-K for the year ended December 31, 2018, File No. 000-54748)</A></FONT></TD></TR>
  <TR STYLE="vertical-align: top; background-color: White">
      <TD STYLE="padding-right: 0.8pt; text-align: center"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">4.8*</FONT></TD>
      <TD STYLE="padding-right: 0.8pt">&nbsp;</TD>
      <TD STYLE="padding-right: 0.8pt; text-align: justify"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt"><A HREF="fs82019ex4-8_icageninc.htm">Icagen, Inc. Form of Restricted Stock Agreement under the 2018 Stock Incentive Plan</A></FONT></TD></TR>
  <TR STYLE="vertical-align: top; background-color: rgb(204,238,255)">
      <TD STYLE="padding-right: 0.8pt; text-align: center"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">4.9*</FONT></TD>
      <TD STYLE="padding-right: 0.8pt">&nbsp;</TD>
      <TD STYLE="padding-right: 0.8pt; text-align: justify"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt"><A HREF="fs82019ex4-9_icageninc.htm">Icagen, Inc. Form of Restricted Stock Unit Award Agreement under the 2018 Stock Incentive Plan</A></FONT></TD></TR>
  <TR STYLE="vertical-align: top; background-color: White">
      <TD STYLE="padding-right: 0.8pt; text-align: center"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">5.1*</FONT></TD>
      <TD STYLE="padding-right: 0.8pt">&nbsp;</TD>
      <TD STYLE="padding-right: 0.8pt; text-align: justify"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt"><A HREF="fs82019ex5-1_icageninc.htm">Opinion of Gracin &amp; Marlow, LLP</A></FONT></TD></TR>
  <TR STYLE="vertical-align: top; background-color: rgb(204,238,255)">
      <TD STYLE="padding-right: 0.8pt; text-align: center"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">23.1*</FONT></TD>
      <TD STYLE="padding-right: 0.8pt">&nbsp;</TD>
      <TD STYLE="padding-right: 0.8pt; text-align: justify"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt"><A HREF="fs82019ex23-1_icageninc.htm" STYLE="-sec-extract: exhibit">Consent of RBSM, LLP, Independent Registered Public Accounting Firm</A></FONT></TD></TR>
  <TR STYLE="vertical-align: top; background-color: White">
      <TD STYLE="padding-right: 0.8pt; text-align: center"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">23.2*</FONT></TD>
      <TD STYLE="padding-right: 0.8pt">&nbsp;</TD>
      <TD STYLE="padding-right: 0.8pt; text-align: justify"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt"><A HREF="fs82019ex5-1_icageninc.htm">Consent of Gracin &amp; Marlow, LLP (included in Exhibit 5.1)</A></FONT></TD></TR>
  <TR STYLE="vertical-align: top; background-color: rgb(204,238,255)">
      <TD STYLE="padding-right: 0.8pt; text-align: center"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">24.1*</FONT></TD>
      <TD STYLE="padding-right: 0.8pt">&nbsp;</TD>
      <TD STYLE="padding-right: 0.8pt; text-align: justify"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt"><A HREF="#poa">Power of Attorney (included as part of the signature page to this Registration Statement and incorporated herein by reference)</A></FONT></TD></TR>
  </TABLE>
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"></P>
  
  <!-- Field: Rule-Page --><DIV ALIGN="LEFT" STYLE="margin-top: 0; margin-bottom: 0"><DIV STYLE="font-size: 1pt; border-top: Black 1.5pt solid; width: 25%">&nbsp;</DIV></DIV><!-- Field: /Rule-Page -->
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0.8pt 0pt 0; text-align: justify">* Filed herewith.</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B>Item 9. Undertakings</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">The undersigned Registrant hereby undertakes:</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">1. To file, during any period in which
  offers or sales are being made, a post-effective amendment to this registration statement:</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.5in">i. To include any prospectus
  required by Section 10(a)(3) of the Securities Act of 1933, as amended;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.5in">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.5in">ii. To reflect in the
  prospectus any facts or events arising after the effective date of this registration statement (or the most recent post-effective
  amendment thereof) which, individually or in the aggregate, represent a fundamental change in the information set forth in this
  Registration Statement;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.5in">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.5in">iii. To include any
  material information with respect to the plan of distribution not previously disclosed in this registration statement or any material
  change to such information in the registration statement; provided, however, that paragraphs (a)(1)(i) and (a)(1)(ii) do not apply
  if the information required to be included in a post-effective amendment by those paragraphs is contained in periodic reports filed
  by the Registrant pursuant to Section 13 or Section 15(d) of the Securities Exchange Act of 1934 that are incorporated by reference
  in this Registration Statement.</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">2. That, for the purpose of determining
  any liability under the Securities Act of 1933, each such post-effective amendment shall be deemed to be a new registration statement
  relating to the securities offered therein, and the offering of such securities at that time shall be deemed to be the initial
  bona fide offering thereof.</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">3. To remove from registration by means
  of a post-effective amendment any of the securities being registered that remain unsold at the termination of the offering.</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">4. That, for purposes of determining any
  liability under the Securities Act of 1933, each filing of the Registrant&rsquo;s annual report pursuant to section 13(a) or section
  15(d) of the Securities Exchange Act of 1934 (and, where applicable, each filing of an employee benefit plan&rsquo;s annual report pursuant
  to section 15(d) of the Securities Exchange Act of 1934) that is incorporated by reference in the registration statement shall
  be deemed to be a new registration statement relating to the securities offered therein, and the offering of such securities at
  that time shall be deemed to be the initial bona fide offering thereof.</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">5. Insofar as indemnification for liabilities
  arising under the Securities Act of 1933 may be permitted to directors, officers and controlling persons of the Registrant, the
  Registrant has been advised that in the opinion of the SEC such indemnification is against public policy as expressed in the Securities
  Act and is, therefore, unenforceable. In the event that a claim for indemnification against such liabilities (other than the payment
  by the Registrant of expenses incurred or paid by a director, officer or controlling person of the Registrant in the successful
  defense of any action, suit or proceeding) is asserted by such director, officer or controlling person in connection with the securities
  being registered, the Registrant will, unless in the opinion of its counsel the matter has been settled by controlling precedent,
  submit to a court of appropriate jurisdiction the question whether such indemnification by it is against public policy as expressed
  in the Securities Act and will be governed by the final adjudication of such issue.</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;&nbsp;</P>
  
  
  <!-- Field: Page; Sequence: 7; Value: 1 -->
      <DIV STYLE="margin-top: 12pt; margin-bottom: 6pt; border-bottom: Black 1.5pt solid"><P STYLE="margin-top: 0pt; text-align: center; margin-bottom: 0pt">II-<!-- Field: Sequence; Type: Arabic; Name: PageNo -->3<!-- Field: /Sequence --></P></DIV>
      <DIV STYLE="page-break-before: always; margin-top: 6pt; margin-bottom: 12pt"><P STYLE="margin: 0pt">&nbsp;</P></DIV>
      <!-- Field: /Page -->
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B>&nbsp;</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center"><B>SIGNATURES</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.5in">Pursuant to the requirements
  of the Securities Act of 1933, the Registrant certifies that it has reasonable grounds to believe that it meets all of the requirements
  for filing on Form S-8 and has duly caused this registration statement to be signed on its behalf by the undersigned, thereunto
  duly authorized, in the City of Durham, State of North Carolina, on the 12<SUP>th</SUP> day of April, 2019.</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
  
  <TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
  <TR STYLE="vertical-align: top">
      <TD>&nbsp;</TD>
      <TD COLSPAN="2"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt"><B>ICAGEN, INC.</B></FONT></TD></TR>
  <TR STYLE="vertical-align: top">
      <TD STYLE="width: 60%">&nbsp;</TD>
      <TD STYLE="width: 6%">&nbsp;</TD>
      <TD STYLE="width: 34%">&nbsp;</TD></TR>
  <TR STYLE="vertical-align: top">
      <TD STYLE="padding-bottom: 1.5pt">&nbsp;</TD>
      <TD STYLE="padding-bottom: 1.5pt"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">By:</FONT></TD>
      <TD STYLE="border-bottom: Black 1.5pt solid"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">/s/ Richard Cunningham</FONT></TD></TR>
  <TR STYLE="vertical-align: top">
      <TD>&nbsp;</TD>
      <TD><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">Name:</FONT></TD>
      <TD><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">Richard Cunningham</FONT></TD></TR>
  <TR STYLE="vertical-align: top">
      <TD>&nbsp;</TD>
      <TD><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">Title:</FONT></TD>
      <TD><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">Chief Executive Officer</FONT></TD></TR>
  </TABLE>
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>&nbsp;</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center"><B><A NAME="poa"></A>POWER OF ATTORNEY AND SIGNATURES</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.5in">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.5in">Each of the undersigned,
  whose signature appears below, hereby constitutes and appoints Richard Cunningham as his true and lawful attorney-in-fact and agent,
  with full power of substitution and resubstitution for him and in his name, place and stead, in any and all capacities, to sign
  any or all amendments to this Registration Statement, whether pre-effective or post-effective, and to file the same with all exhibits
  thereto and other documents in connection therewith, with the Commission, granting unto said attorney-in-fact and agent, or his
  substitute or substitutes, and each of them, full power and authority to do and perform each and every act and thing necessary
  or appropriate to be done with respect to this Registration Statement or any amendments hereto in the premises, as fully to all
  intents and purposes as he or she might or could do in person, hereby ratifying and confirming all that said attorney-in-fact and
  agent, or his substitute or substitutes, or any of them, may lawfully do or cause to be done by virtue thereof.</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.5in">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.5in">Pursuant to the requirements
  of the Securities Act of 1933, as amended, this registration statement has been signed by the following persons in the capacities
  and on the dates indicated.</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;&nbsp;</P>
  
  <TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
  <TR STYLE="vertical-align: top">
      <TD STYLE="width: 32%; padding-right: 0; padding-left: 0; text-align: center; text-indent: 0; border-bottom: Black 1.5pt solid"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt"><B>Signature</B></FONT></TD>
      <TD STYLE="width: 2%; padding-right: 0; padding-left: 0; text-indent: 0; padding-bottom: 1.5pt">&nbsp;</TD>
      <TD STYLE="padding-right: 0; padding-left: 0; text-align: center; text-indent: 0; border-bottom: Black 1.5pt solid; width: 44%"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt"><B>Title</B></FONT></TD>
      <TD STYLE="width: 2%; padding-right: 0; padding-left: 0; text-indent: 0; padding-bottom: 1.5pt">&nbsp;</TD>
      <TD STYLE="width: 20%; padding-right: 0; padding-left: 0; text-align: center; text-indent: 0; border-bottom: Black 1.5pt solid"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt"><B>Date</B></FONT></TD></TR>
  <TR STYLE="vertical-align: top">
      <TD STYLE="padding-right: 0; padding-left: 0; text-indent: 0">&nbsp;</TD>
      <TD STYLE="padding-right: 0; padding-left: 0; text-indent: 0">&nbsp;</TD>
      <TD STYLE="padding-right: 0; padding-left: 0; text-indent: 0">&nbsp;</TD>
      <TD STYLE="padding-right: 0; padding-left: 0; text-indent: 0">&nbsp;</TD>
      <TD STYLE="padding-right: 0; padding-left: 0; text-indent: 0">&nbsp;</TD></TR>
  <TR STYLE="vertical-align: top">
      <TD STYLE="padding-right: 0; padding-left: 0; text-indent: 0; border-bottom: Black 1.5pt solid"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">/s/ Richard Cunningham</FONT></TD>
      <TD STYLE="padding-right: 0; padding-left: 0; text-indent: 0">&nbsp;</TD>
      <TD ROWSPAN="2" STYLE="padding-right: 0; padding-left: 0; text-indent: 0">
          <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">Chief Executive Officer</P>
          <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">(Principal Executive Officer)</P></TD>
      <TD STYLE="padding-right: 0; padding-left: 0; text-indent: 0">&nbsp;</TD>
      <TD STYLE="padding-right: 0; padding-left: 0; text-align: center; text-indent: 0"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">April 12, 2019</FONT></TD></TR>
  <TR STYLE="vertical-align: top">
      <TD STYLE="padding-right: 0; padding-left: 0; text-indent: 0">
          <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Richard Cunningham</P>
          <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P></TD>
      <TD STYLE="padding-right: 0; padding-left: 0; text-indent: 0">&nbsp;</TD>
      <TD STYLE="padding-right: 0; padding-left: 0; text-indent: 0">&nbsp;</TD>
      <TD STYLE="padding-right: 0; padding-left: 0; text-indent: 0">&nbsp;</TD></TR>
  <TR STYLE="vertical-align: top">
      <TD STYLE="padding-right: 0; padding-left: 0; text-indent: 0; border-bottom: Black 1.5pt solid"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">/s/ Mark Korb</FONT></TD>
      <TD STYLE="padding-right: 0; padding-left: 0; text-indent: 0">&nbsp;</TD>
      <TD ROWSPAN="2" STYLE="padding-right: 0; padding-left: 0; text-indent: 0">
          <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">Chief Financial Officer</P>
          <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">(Principal Financial Officer and Principal
          Accounting Officer)</P></TD>
      <TD STYLE="padding-right: 0; padding-left: 0; text-indent: 0">&nbsp;</TD>
      <TD STYLE="padding-right: 0; padding-left: 0; text-align: center; text-indent: 0">April 12, 2019</TD></TR>
  <TR STYLE="vertical-align: top">
      <TD STYLE="padding-right: 0; padding-left: 0; text-indent: 0">
          <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Mark Korb</P>
          <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P></TD>
      <TD STYLE="padding-right: 0; padding-left: 0; text-indent: 0">&nbsp;</TD>
      <TD STYLE="padding-right: 0; padding-left: 0; text-indent: 0">&nbsp;</TD>
      <TD STYLE="padding-right: 0; padding-left: 0; text-indent: 0">&nbsp;</TD></TR>
  <TR STYLE="vertical-align: top">
      <TD STYLE="padding-right: 0; padding-left: 0; text-indent: 0; border-bottom: Black 1.5pt solid; text-align: left; vertical-align: bottom"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">/s/ Timothy Tyson</FONT></TD>
      <TD STYLE="padding-right: 0; padding-left: 0; text-indent: 0">&nbsp;</TD>
      <TD STYLE="padding-right: 0; padding-left: 0; text-indent: 0">
          <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>
          <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">Chairman of the Board of Directors</P></TD>
      <TD STYLE="padding-right: 0; padding-left: 0; text-indent: 0">&nbsp;</TD>
      <TD STYLE="padding-right: 0; padding-left: 0; text-align: center; text-indent: 0; vertical-align: bottom">April 12, 2019</TD></TR>
  <TR STYLE="vertical-align: top">
      <TD STYLE="padding-right: 0; padding-left: 0; text-indent: 0">
          <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Timothy Tyson</P>
          <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P></TD>
      <TD STYLE="padding-right: 0; padding-left: 0; text-indent: 0">&nbsp;</TD>
      <TD STYLE="padding-right: 0; padding-left: 0; text-indent: 0">&nbsp;</TD>
      <TD STYLE="padding-right: 0; padding-left: 0; text-indent: 0">&nbsp;</TD>
      <TD STYLE="padding-right: 0; padding-left: 0; text-indent: 0">&nbsp;</TD></TR>
  <TR STYLE="vertical-align: top">
      <TD STYLE="padding-right: 0; padding-left: 0; text-indent: 0; border-bottom: Black 1.5pt solid"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">/s/ Clive Kabatznik</FONT></TD>
      <TD STYLE="padding-right: 0; padding-left: 0; text-indent: 0">&nbsp;</TD>
      <TD STYLE="padding-right: 0; padding-left: 0; text-align: center; text-indent: 0"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">Director</FONT></TD>
      <TD STYLE="padding-right: 0; padding-left: 0; text-indent: 0">&nbsp;</TD>
      <TD STYLE="padding-right: 0; padding-left: 0; text-align: center; text-indent: 0">April 12, 2019</TD></TR>
  <TR STYLE="vertical-align: top">
      <TD STYLE="padding-right: 0; padding-left: 0; text-indent: 0">
          <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Clive Kabatznik</P>
          <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P></TD>
      <TD STYLE="padding-right: 0; padding-left: 0; text-indent: 0">&nbsp;</TD>
      <TD STYLE="padding-right: 0; padding-left: 0; text-indent: 0">&nbsp;</TD>
      <TD STYLE="padding-right: 0; padding-left: 0; text-indent: 0">&nbsp;</TD>
      <TD STYLE="padding-right: 0; padding-left: 0; text-indent: 0">&nbsp;</TD></TR>
  <TR STYLE="vertical-align: top">
      <TD STYLE="padding-right: 0; padding-left: 0; text-indent: 0; border-bottom: Black 1.5pt solid"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">/s/ Vincent Palmieri </FONT></TD>
      <TD STYLE="padding-right: 0; padding-left: 0; text-indent: 0">&nbsp;</TD>
      <TD STYLE="padding-right: 0; padding-left: 0; text-align: center; text-indent: 0"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">Director</FONT></TD>
      <TD STYLE="padding-right: 0; padding-left: 0; text-indent: 0">&nbsp;</TD>
      <TD STYLE="padding-right: 0; padding-left: 0; text-align: center; text-indent: 0">April 12, 2019</TD></TR>
  <TR STYLE="vertical-align: top">
      <TD STYLE="padding-right: 0; padding-left: 0; text-indent: 0">
          <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Vincent Palmieri</P>
          <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P></TD>
      <TD STYLE="padding-right: 0; padding-left: 0; text-indent: 0">&nbsp;</TD>
      <TD STYLE="padding-right: 0; padding-left: 0; text-indent: 0">&nbsp;</TD>
      <TD STYLE="padding-right: 0; padding-left: 0; text-indent: 0">&nbsp;</TD>
      <TD STYLE="padding-right: 0; padding-left: 0; text-align: center; text-indent: 0">&nbsp;</TD></TR>
  <TR STYLE="vertical-align: top">
      <TD STYLE="padding-right: 0; padding-left: 0; text-indent: 0; border-bottom: Black 1.5pt solid"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt"><U STYLE="text-decoration: none">/s/
  Edward Roffman</U></FONT></TD>
      <TD STYLE="padding-right: 0; padding-left: 0; text-indent: 0">&nbsp;</TD>
      <TD STYLE="padding-right: 0; padding-left: 0; text-align: center; text-indent: 0"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">Director</FONT></TD>
      <TD STYLE="padding-right: 0; padding-left: 0; text-indent: 0">&nbsp;</TD>
      <TD STYLE="padding-right: 0; padding-left: 0; text-align: center; text-indent: 0">April 12, 2019</TD></TR>
  <TR STYLE="vertical-align: top">
      <TD STYLE="padding-right: 0; padding-left: 0; text-indent: 0">
          <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Edward Roffman</P>
          <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P></TD>
      <TD STYLE="padding-right: 0; padding-left: 0; text-indent: 0">&nbsp;</TD>
      <TD STYLE="padding-right: 0; padding-left: 0; text-indent: 0">&nbsp;</TD>
      <TD STYLE="padding-right: 0; padding-left: 0; text-indent: 0">&nbsp;</TD>
      <TD STYLE="padding-right: 0; padding-left: 0; text-indent: 0">&nbsp;</TD></TR>
  <TR STYLE="vertical-align: top">
      <TD STYLE="padding-right: 0; padding-left: 0; text-indent: 0; border-bottom: Black 1.5pt solid"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt"><U STYLE="text-decoration: none">/s/
  Michael Taglich</U></FONT></TD>
      <TD STYLE="padding-right: 0; padding-left: 0; text-indent: 0">&nbsp;</TD>
      <TD STYLE="padding-right: 0; padding-left: 0; text-align: center; text-indent: 0"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">Director</FONT></TD>
      <TD STYLE="padding-right: 0; padding-left: 0; text-indent: 0">&nbsp;</TD>
      <TD STYLE="padding-right: 0; padding-left: 0; text-align: center; text-indent: 0">April 12, 2019</TD></TR>
  <TR STYLE="vertical-align: top">
      <TD STYLE="padding-right: 0; padding-left: 0; text-indent: 0"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">Michael Taglich</FONT></TD>
      <TD STYLE="padding-right: 0; padding-left: 0; text-indent: 0">&nbsp;</TD>
      <TD STYLE="padding-right: 0; padding-left: 0; text-indent: 0">&nbsp;</TD>
      <TD STYLE="padding-right: 0; padding-left: 0; text-indent: 0">&nbsp;</TD>
      <TD STYLE="padding-right: 0; padding-left: 0; text-indent: 0">&nbsp;</TD></TR>
  </TABLE>
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B>&nbsp;</B></P>
  
  
  <!-- Field: Page; Sequence: 8; Value: 1 -->
      <DIV STYLE="margin-top: 12pt; margin-bottom: 6pt; border-bottom: Black 1.5pt solid"><P STYLE="margin-top: 0pt; text-align: center; margin-bottom: 0pt">II-<!-- Field: Sequence; Type: Arabic; Name: PageNo -->4<!-- Field: /Sequence --></P></DIV>
      <DIV STYLE="page-break-before: always; margin-top: 6pt; margin-bottom: 12pt"><P STYLE="margin: 0pt">&nbsp;</P></DIV>
      <!-- Field: /Page -->
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B>&nbsp;</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>EXHIBIT INDEX</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
  
  <TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
  <TR STYLE="vertical-align: top">
      <TD STYLE="width: 10%; text-align: center; border-bottom: Black 1.5pt solid"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt"><B>Exhibit&nbsp;No.</B></FONT></TD>
      <TD STYLE="width: 1%; padding-bottom: 1.5pt">&nbsp;</TD>
      <TD STYLE="width: 89%; border-bottom: Black 1.5pt solid"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt"><B>Description&nbsp;of&nbsp;Document</B></FONT></TD></TR>
  <TR STYLE="vertical-align: top; background-color: rgb(204,238,255)">
      <TD STYLE="padding-right: 0.8pt; text-align: center"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">4.1</FONT></TD>
      <TD STYLE="padding-right: 0.8pt">&nbsp;</TD>
      <TD STYLE="padding-right: 0.8pt; text-align: justify"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt"><A HREF="http://www.sec.gov/Archives/edgar/data/1518520/000121390012001987/fs1a1ex3v_caldera.htm">Second Amended and Restated Certificate of Incorporation dated April 10, 2012 (Incorporated by reference to the Registration Statement on Form S-1/A filed April 20, 2012, File No. 333-179508)</A></FONT></TD></TR>
  <TR STYLE="vertical-align: top; background-color: White">
      <TD STYLE="padding-right: 0.8pt; text-align: center"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">4.2</FONT></TD>
      <TD STYLE="padding-right: 0.8pt">&nbsp;</TD>
      <TD STYLE="padding-right: 0.8pt; text-align: justify"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt"><A HREF="http://www.sec.gov/Archives/edgar/data/1518520/000121390014008757/f8k120214ex3i_calderapharm.htm">Certificate of Amendment to the Second Amended and Restated Certificate of Incorporation (Incorporated by reference to the Current Report on Form 8-K filed on December 5, 2014, File No. 000-54748)</A></FONT></TD></TR>
  <TR STYLE="vertical-align: top; background-color: rgb(204,238,255)">
      <TD STYLE="padding-right: 0.8pt; text-align: center"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">4.3</FONT></TD>
      <TD STYLE="padding-right: 0.8pt">&nbsp;</TD>
      <TD STYLE="padding-right: 0.8pt; text-align: justify"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt"><A HREF="http://www.sec.gov/Archives/edgar/data/1518520/000121390015001344/f8k022015ex3i_xrprosciences.htm">Amended and Restated Bylaws (Incorporated by reference to the Current Report on Form 8-K filed on February 25, 2015, File No. 000-54748)</A></FONT></TD></TR>
  <TR STYLE="vertical-align: top; background-color: White">
      <TD STYLE="padding-right: 0.8pt; text-align: center"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">4.4</FONT></TD>
      <TD STYLE="padding-right: 0.8pt">&nbsp;</TD>
      <TD STYLE="padding-right: 0.8pt; text-align: justify"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt"><A HREF="http://www.sec.gov/Archives/edgar/data/1518520/000121390015002106/f8k032415ex3i_xrpro.htm">Certificate of Amendment to Second Amended and Restated Certificate of Incorporation (Incorporated by reference to the Current Report on Form 8-K filed March 26, 2015, File No. 000-54748)</A></FONT></TD></TR>
  <TR STYLE="vertical-align: top; background-color: rgb(204,238,255)">
      <TD STYLE="padding-right: 0.8pt; text-align: center"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">4.5</FONT></TD>
      <TD STYLE="padding-right: 0.8pt">&nbsp;</TD>
      <TD STYLE="padding-right: 0.8pt; text-align: justify"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt"><A HREF="http://www.sec.gov/Archives/edgar/data/1518520/000121390015006651/f8k082815ex3i_icageninc.htm">Certificate of Amendment to the Second Amended and Restated Certificate of Incorporation (Incorporated by reference to the Current Report on Form 8-K filed August 31, 2015, File No. 000-54748)</A></FONT></TD></TR>
  <TR STYLE="vertical-align: top; background-color: White">
      <TD STYLE="padding-right: 0.8pt; text-align: center"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">4.6</FONT></TD>
      <TD STYLE="padding-right: 0.8pt">&nbsp;</TD>
      <TD STYLE="padding-right: 0.8pt; text-align: justify"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt"><A HREF="http://www.sec.gov/Archives/edgar/data/1518520/000121390018018007/def14c1218_icageninc.htm#annex_b">Icagen, Inc. 2018 Stock Incentive Plan (Incorporated by reference to Exhibit B to the Definitive Information Statement on Schedule 14C filed with the Securities and Exchange Commission on December 31, 2018)</A></FONT></TD></TR>
  <TR STYLE="vertical-align: top; background-color: rgb(204,238,255)">
      <TD STYLE="padding-right: 0.8pt; text-align: center"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">4.7</FONT></TD>
      <TD STYLE="padding-right: 0.8pt">&nbsp;</TD>
      <TD STYLE="padding-right: 0.8pt; text-align: justify"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt"><A HREF="http://www.sec.gov/Archives/edgar/data/1518520/000121390019006256/f10k2018ex4-24_icagen.htm">Icagen, Inc. Form of Stock Option Agreement under the 2018 Stock Incentive Plan (Incorporated by reference to the Annual Report on Form 10-K for the year ended December 31, 2018, File No. 000-54748)</A></FONT></TD></TR>
  <TR STYLE="vertical-align: top; background-color: White">
      <TD STYLE="padding-right: 0.8pt; text-align: center"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">4.8*</FONT></TD>
      <TD STYLE="padding-right: 0.8pt">&nbsp;</TD>
      <TD STYLE="padding-right: 0.8pt; text-align: justify"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt"><A HREF="fs82019ex4-8_icageninc.htm">Icagen, Inc. Form of Restricted Stock Agreement under the 2018 Stock Incentive Plan</A></FONT></TD></TR>
  <TR STYLE="vertical-align: top; background-color: rgb(204,238,255)">
      <TD STYLE="padding-right: 0.8pt; text-align: center"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">4.9*</FONT></TD>
      <TD STYLE="padding-right: 0.8pt">&nbsp;</TD>
      <TD STYLE="padding-right: 0.8pt; text-align: justify"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt"><A HREF="fs82019ex4-9_icageninc.htm">Icagen, Inc. Form of Restricted Stock Unit Award Agreement under the 2018 Stock Incentive Plan</A></FONT></TD></TR>
  <TR STYLE="vertical-align: top; background-color: White">
      <TD STYLE="padding-right: 0.8pt; text-align: center"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">5.1*</FONT></TD>
      <TD STYLE="padding-right: 0.8pt">&nbsp;</TD>
      <TD STYLE="padding-right: 0.8pt; text-align: justify"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt"><A HREF="fs82019ex5-1_icageninc.htm">Opinion of Gracin &amp; Marlow, LLP</A></FONT></TD></TR>
  <TR STYLE="vertical-align: top; background-color: rgb(204,238,255)">
      <TD STYLE="padding-right: 0.8pt; text-align: center"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">23.1*</FONT></TD>
      <TD STYLE="padding-right: 0.8pt">&nbsp;</TD>
      <TD STYLE="padding-right: 0.8pt; text-align: justify"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt"><A HREF="fs82019ex23-1_icageninc.htm" STYLE="-sec-extract: exhibit">Consent of RBSM, LLP, Independent Registered Public Accounting Firm</A></FONT></TD></TR>
  <TR STYLE="vertical-align: top; background-color: White">
      <TD STYLE="padding-right: 0.8pt; text-align: center"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">23.2*</FONT></TD>
      <TD STYLE="padding-right: 0.8pt">&nbsp;</TD>
      <TD STYLE="padding-right: 0.8pt; text-align: justify"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt"><A HREF="fs82019ex5-1_icageninc.htm">Consent of Gracin &amp; Marlow, LLP (included in Exhibit 5.1)</A></FONT></TD></TR>
  <TR STYLE="vertical-align: top; background-color: rgb(204,238,255)">
      <TD STYLE="padding-right: 0.8pt; text-align: center"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">24.1*</FONT></TD>
      <TD STYLE="padding-right: 0.8pt">&nbsp;</TD>
      <TD STYLE="padding-right: 0.8pt; text-align: justify"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt"><A HREF="#poa">Power of Attorney (included as part of the signature page to this Registration Statement and incorporated herein by reference)</A></FONT></TD></TR>
  </TABLE>
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  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0.8pt 0pt 0; text-align: justify">* Filed herewith.</P>
  
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metadata_documents: [{"type": "S-8", "sequence": "1", "filename": "fs82019_icageninc.htm", "description": "REGISTRATION STATEMENT", "secsgml_size_bytes": 76507}]
metadata_filer: {"company-data": {"conformed-name": "Icagen, Inc.", "cik": "0001518520", "assigned-sic": "8731", "irs-number": "200982060", "state-of-incorporation": "DE", "fiscal-year-end": "1231"}, "filing-values": {"form-type": "S-8", "act": "33", "file-number": "333-230849", "film-number": "19747024"}, "business-address": {"street1": "4222 EMPEROR BLVD., SUITE 350", "street2": "RESEARCH TRIANGLE PARK", "city": "DURHAM", "state": "NC", "zip": "27703", "phone": "919-941-5206"}, "mail-address": {"street1": "4222 EMPEROR BLVD., SUITE 350", "street2": "RESEARCH TRIANGLE PARK", "city": "DURHAM", "state": "NC", "zip": "27703"}, "former-company": [{"former-conformed-name": "XRpro Sciences, Inc.", "date-changed": "20141204"}, {"former-conformed-name": "Caldera Pharmaceuticals Inc", "date-changed": "20110419"}]}
text: As filed with the Securities and Exchange
  Commission on April 12, 2019
  Registration No. 333-
  UNITED STATES
  SECURITIES AND EXCHANGE COMMISSION
  WASHINGTON, D.C. 20549
  FORM S-8
  REGISTRATION STATEMENT
  UNDER
  THE SECURITIES ACT OF 1933
  ICAGEN, INC.
  (Exact name of registrant as specified
  in its charter)
  Delaware
  20-0982060
  (State
  or other jurisdiction of
  incorporation or organization)
  (I.R.S. Employer
  Identification Number)
  4222 Emperor Blvd., Suite 350
  Research Triangle Park
  Durham, North Carolina 27703
  (919) 941-5206
  (Address, including ZIP code, and telephone
  number, including
  area code, of registrant's principal
  executive office)
  ICAGEN, INC. 2018 STOCK INCENTIVE PLAN
  (Full title of the Plan)
  Richard Cunningham
  Chief Executive Officer
  Icagen, Inc.
  4222 Emperor Blvd., Suite 350
  Research Triangle Park
  Durham, North Carolina 27703
  (919) 941-5206
  (Name, address and telephone number of
  agent of services)
  WITH COPIES TO:
  Leslie Marlow, Esq.
  Hank Gracin, Esq
  Patrick J. Egan, Esq.
  Gracin & Marlow, LLP
  The Chrysler Building
  405 Lexington Avenue, 26
  th
  Floor
  New York, New York 10174
  (212) 907-6457
  (Name, address and telephone number)
  Indicate by check mark whether the registrant
  is a large accelerated filer, an accelerated filer, a non-accelerated filer, a smaller reporting company or an emerging growth
  company. See the definitions of "large accelerated filer," "accelerated filer" "smaller reporting
  company" and "emerging growth company" in Rule 12b-2 of the Exchange Act:
  Large accelerated filer
  ☐
  Accelerated filer
  ☐
  Non-accelerated filer
  þ
  Smaller reporting company
  þ
  Emerging growth company
  ☐
  If
  an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for
  complying with any new or revised financial accounting standards provided pursuant to Section 13(a) of the Exchange Act.
  ¨
  CALCULATION OF REGISTRATION FEE
  Title of Securities to be Registered
  Amount to be
  Registered
  (1)(2)
  Proposed Maximum
  Offering Price
  Per
  Share(3)
  Proposed Maximum
  Aggregate
  Offering
  Price(3)
  Amount of
  Registration
  Fee(4)
  Common Stock, par   value $0.001 per share, under the 2018 Stock Incentive Plan
  2,000,000 shares
  $
  3.50
  $
  7,000,000
  $
  848.40
  (1)
  The securities to be registered include options and other
  rights to acquire the common stock of Icagen, Inc. (the "Registrant").
  (2)
  Pursuant to Rule 416(a) under the Securities Act of 1933,
  as amended (the "Securities Act"), this registration statement also covers any additional securities that may be offered
  or issued in connection with any stock split, stock dividend or similar transaction.
  (3)
  Estimated solely for the purpose of calculating the registration
  fee pursuant to Rule 457(h) under the Securities Act.
  (4)
  Calculated under Section 6(b) of the Securities Act as
  ..00012120 of the proposed maximum aggregate offering price.
  EXPLANATORY NOTE
  Icagen, Inc. (the "Registrant"
  or the "Company") hereby files this Registration Statement on Form S-8 relating to its common stock, par value $0.001
  per share (the "Common Stock"), which have been reserved for issuance and are issuable pursuant to the Company's
  2018 Stock Incentive Plan (hereinafter referred to as the "Plan").
  PART I
  INFORMATION REQUIRED IN THE SECTION 10(a)
  PROSPECTUS
  Item 1. Plan Information.*
  Item 2. Registrant Information and Employee Plan Annual
  Information.*
  *The information specified
  in Item 1 and Item 2 of Part I of this Registration Statement on Form S-8 is omitted from this filing in accordance with the provisions
  of Rule 428 under the Securities Act of 1933, as amended (the "Securities Act"), and the introductory note to Part
  I of Form S-8. The documents containing the information specified in Part I will be delivered to the participants in the Plan as
  required by Rule 428. Such documents and the documents incorporated by reference in this Registration Statement pursuant to Item
  3 of Part II of this Registration Statement, taken together, constitute a prospectus that meets the requirements of Section 10(a)
  of the Securities Act.
  1
  PART II
  INFORMATION REQUIRED IN THE REGISTRATION
  STATEMENT
  Item 3. Incorporation of Documents by Reference.
  The Securities and
  Exchange Commission (the "SEC") allows us to "incorporate by reference" the information we file with it
  which means that we can disclose important information to you by referring you to those documents instead of having to repeat the
  information in this prospectus. The information incorporated by reference is considered to be part of this prospectus, and later
  information that we file with the SEC will automatically update and supersede this information. We incorporate by reference the
  documents listed below and any future filings made with the SEC under Sections 13(a), 13(c), 14 or 15(d) of the Securities
  Exchange Act of 1934, as amended (the "Exchange Act"), between the date of this prospectus and the termination of the
  offering:
  ●
  Our Annual Report on Form 10-K for the year ended December 31, 2018 (File No. 000-54748) filed with the SEC on April 12, 2019;
  ●
  Our Definitive Information Statement on Schedule 14C filed on December 31, 2018; and
  ●
  The description of our common stock set forth in our registration statement on Form 8-A, filed with the SEC on June 28, 2012 (File No. 000-54748).
  All reports and other
  documents subsequently filed by the Company pursuant to Sections 13(a), 13(c), 14 or 15(d) of the Exchange Act shall be deemed
  to be incorporated by reference in this Registration Statement and to be a part of this Registration Statement from the respective
  date of filing of each of those reports or documents until the filing of a post-effective amendment to this Registration Statement
  which indicates either that all securities offered by this Registration Statement have been sold or which deregisters all of the
  securities under this Registration Statement then remaining unsold.
  II-
  1
  Any statement contained
  in this Registration Statement or in a document incorporated or deemed to be incorporated by reference in this Registration Statement
  shall be deemed to be modified or superseded for purposes of this Registration Statement to the extent that a statement contained
  in this Registration Statement or in any other subsequently filed document which also is or is deemed to be incorporated by reference
  in this Registration Statement modifies or supersedes that statement. Any statement so modified or superseded shall not be deemed,
  except as so modified or superseded, to constitute a part of this Registration Statement.
  Item 4. Description of Securities.
  Not applicable.
  Item 5. Interests of Named Experts and Counsel.
  As of the date of this Registration Statement, an attorney of Gracin & Marlow, LLP beneficially owns
  securities exercisable to purchase an aggregate of 25,000 shares of the Registrant's capital stock.
  Item 6. Indemnification of Directors and Officers.
  Section 145 of
  the Delaware General Corporation Law (the "DGCL") provides that a corporation may indemnify directors and officers
  as well as other employees and individuals against expenses (including attorneys' fees), judgments, fines and amounts paid
  in settlement actually and reasonably incurred by such person in connection with any threatened, pending or completed actions,
  suits or proceedings in which such person is made a party by reason of such person being or having been a director, officer, employee
  or agent of the Registrant. The DGCL provides that Section 145 is not exclusive of other rights to which those seeking indemnification
  may be entitled under any bylaws, agreement, vote of stockholders or disinterested directors or otherwise. The Registrant's
  Second Amended and Restated Certificate of Incorporation, as amended, and Amended and Restated Bylaws provide for indemnification
  by the Registrant of its directors and officers to the fullest extent permitted by the DGCL.
  Section 102(b)(7)
  of the DGCL permits a corporation to provide in its certificate of incorporation that a director of the corporation shall not be
  personally liable to the corporation or its stockholders for monetary damages for breach of fiduciary duty as a director, except
  for liability (1) for any breach of the director's duty of loyalty to the corporation or its stockholders, (2) for
  acts or omissions not in good faith or which involve intentional misconduct or a knowing violation of law, (3) for unlawful
  payments of dividends or unlawful stock repurchases, redemptions or other distributions or (4) for any transaction from which
  the director derived an improper personal benefit. The Registrant's Second Amended and Restated Certificate of Incorporation,
  as amended, provides for such limitation of liability to the fullest extent permitted by the DGCL.
  The Registrant maintains
  standard policies of insurance under which coverage is provided (1) to its directors and officers against loss rising from
  claims made by reason of breach of duty or other wrongful act, while acting in their capacity as directors and officers of the
  Registrant, and (2) to the Registrant with respect to payments which may be made by the Registrant to such officers and directors
  pursuant to any indemnification provisions contained in the Registrant's Second Amended and Restated Certificate of Incorporation,
  as amended, and Amended and Restated Bylaws or otherwise as a matter of law.
  Item 7. Exemption from Registration Claimed.
  Not applicable.
  II-
  2
  Item 8. Exhibits.
  Exhibit No.
  Description of Document
  4.1
  Second Amended and Restated Certificate of Incorporation dated April 10, 2012 (Incorporated by reference to the Registration Statement on Form S-1/A filed April 20, 2012, File No. 333-179508)
  4.2
  Certificate of Amendment to the Second Amended and Restated Certificate of Incorporation (Incorporated by reference to the Current Report on Form 8-K filed on December 5, 2014, File No. 000-54748)
  4.3
  Amended and Restated Bylaws (Incorporated by reference to the Current Report on Form 8-K filed on February 25, 2015, File No. 000-54748)
  4.4
  Certificate of Amendment to Second Amended and Restated Certificate of Incorporation (Incorporated by reference to the Current Report on Form 8-K filed March 26, 2015, File No. 000-54748)
  4.5
  Certificate of Amendment to the Second Amended and Restated Certificate of Incorporation (Incorporated by reference to the Current Report on Form 8-K filed August 31, 2015, File No. 000-54748)
  4.6
  Icagen, Inc. 2018 Stock Incentive Plan (Incorporated by reference to Exhibit B to the Definitive Information Statement on Schedule 14C filed with the Securities and Exchange Commission on December 31, 2018)
  4.7
  Icagen, Inc. Form of Stock Option Agreement under the 2018 Stock Incentive Plan (Incorporated by reference to the Annual Report on Form 10-K for the year ended December 31, 2018, File No. 000-54748)
  4.8*
  Icagen, Inc. Form of Restricted Stock Agreement under the 2018 Stock Incentive Plan
  4.9*
  Icagen, Inc. Form of Restricted Stock Unit Award Agreement under the 2018 Stock Incentive Plan
  5.1*
  Opinion of Gracin & Marlow, LLP
  23.1*
  Consent of RBSM, LLP, Independent Registered Public Accounting Firm
  23.2*
  Consent of Gracin & Marlow, LLP (included in Exhibit 5.1)
  24.1*
  Power of Attorney (included as part of the signature page to this Registration Statement and incorporated herein by reference)
  * Filed herewith.
  Item 9. Undertakings
  The undersigned Registrant hereby undertakes:
  1. To file, during any period in which
  offers or sales are being made, a post-effective amendment to this registration statement:
  i. To include any prospectus
  required by Section 10(a)(3) of the Securities Act of 1933, as amended;
  ii. To reflect in the
  prospectus any facts or events arising after the effective date of this registration statement (or the most recent post-effective
  amendment thereof) which, individually or in the aggregate, represent a fundamental change in the information set forth in this
  Registration Statement;
  iii. To include any
  material information with respect to the plan of distribution not previously disclosed in this registration statement or any material
  change to such information in the registration statement; provided, however, that paragraphs (a)(1)(i) and (a)(1)(ii) do not apply
  if the information required to be included in a post-effective amendment by those paragraphs is contained in periodic reports filed
  by the Registrant pursuant to Section 13 or Section 15(d) of the Securities Exchange Act of 1934 that are incorporated by reference
  in this Registration Statement.
  2. That, for the purpose of determining
  any liability under the Securities Act of 1933, each such post-effective amendment shall be deemed to be a new registration statement
  relating to the securities offered therein, and the offering of such securities at that time shall be deemed to be the initial
  bona fide offering thereof.
  3. To remove from registration by means
  of a post-effective amendment any of the securities being registered that remain unsold at the termination of the offering.
  4. That, for purposes of determining any
  liability under the Securities Act of 1933, each filing of the Registrant's annual report pursuant to section 13(a) or section
  15(d) of the Securities Exchange Act of 1934 (and, where applicable, each filing of an employee benefit plan's annual report pursuant
  to section 15(d) of the Securities Exchange Act of 1934) that is incorporated by reference in the registration statement shall
  be deemed to be a new registration statement relating to the securities offered therein, and the offering of such securities at
  that time shall be deemed to be the initial bona fide offering thereof.
  5. Insofar as indemnification for liabilities
  arising under the Securities Act of 1933 may be permitted to directors, officers and controlling persons of the Registrant, the
  Registrant has been advised that in the opinion of the SEC such indemnification is against public policy as expressed in the Securities
  Act and is, therefore, unenforceable. In the event that a claim for indemnification against such liabilities (other than the payment
  by the Registrant of expenses incurred or paid by a director, officer or controlling person of the Registrant in the successful
  defense of any action, suit or proceeding) is asserted by such director, officer or controlling person in connection with the securities
  being registered, the Registrant will, unless in the opinion of its counsel the matter has been settled by controlling precedent,
  submit to a court of appropriate jurisdiction the question whether such indemnification by it is against public policy as expressed
  in the Securities Act and will be governed by the final adjudication of such issue.
  II-
  3
  SIGNATURES
  Pursuant to the requirements
  of the Securities Act of 1933, the Registrant certifies that it has reasonable grounds to believe that it meets all of the requirements
  for filing on Form S-8 and has duly caused this registration statement to be signed on its behalf by the undersigned, thereunto
  duly authorized, in the City of Durham, State of North Carolina, on the 12
  th
  day of April, 2019.
  ICAGEN, INC.
  By:
  /s/ Richard Cunningham
  Name:
  Richard Cunningham
  Title:
  Chief Executive Officer
  POWER OF ATTORNEY AND SIGNATURES
  Each of the undersigned,
  whose signature appears below, hereby constitutes and appoints Richard Cunningham as his true and lawful attorney-in-fact and agent,
  with full power of substitution and resubstitution for him and in his name, place and stead, in any and all capacities, to sign
  any or all amendments to this Registration Statement, whether pre-effective or post-effective, and to file the same with all exhibits
  thereto and other documents in connection therewith, with the Commission, granting unto said attorney-in-fact and agent, or his
  substitute or substitutes, and each of them, full power and authority to do and perform each and every act and thing necessary
  or appropriate to be done with respect to this Registration Statement or any amendments hereto in the premises, as fully to all
  intents and purposes as he or she might or could do in person, hereby ratifying and confirming all that said attorney-in-fact and
  agent, or his substitute or substitutes, or any of them, may lawfully do or cause to be done by virtue thereof.
  Pursuant to the requirements
  of the Securities Act of 1933, as amended, this registration statement has been signed by the following persons in the capacities
  and on the dates indicated.
  Signature
  Title
  Date
  /s/ Richard Cunningham
  Chief Executive Officer
  (Principal Executive Officer)
  April 12, 2019
  Richard Cunningham
  /s/ Mark Korb
  Chief Financial Officer
  (Principal Financial Officer and Principal
          Accounting Officer)
  April 12, 2019
  Mark Korb
  /s/ Timothy Tyson
  Chairman of the Board of Directors
  April 12, 2019
  Timothy Tyson
  /s/ Clive Kabatznik
  Director
  April 12, 2019
  Clive Kabatznik
  /s/ Vincent Palmieri
  Director
  April 12, 2019
  Vincent Palmieri
  /s/
  Edward Roffman
  Director
  April 12, 2019
  Edward Roffman
  /s/
  Michael Taglich
  Director
  April 12, 2019
  Michael Taglich
  II-
  4
  EXHIBIT INDEX
  Exhibit No.
  Description of Document
  4.1
  Second Amended and Restated Certificate of Incorporation dated April 10, 2012 (Incorporated by reference to the Registration Statement on Form S-1/A filed April 20, 2012, File No. 333-179508)
  4.2
  Certificate of Amendment to the Second Amended and Restated Certificate of Incorporation (Incorporated by reference to the Current Report on Form 8-K filed on December 5, 2014, File No. 000-54748)
  4.3
  Amended and Restated Bylaws (Incorporated by reference to the Current Report on Form 8-K filed on February 25, 2015, File No. 000-54748)
  4.4
  Certificate of Amendment to Second Amended and Restated Certificate of Incorporation (Incorporated by reference to the Current Report on Form 8-K filed March 26, 2015, File No. 000-54748)
  4.5
  Certificate of Amendment to the Second Amended and Restated Certificate of Incorporation (Incorporated by reference to the Current Report on Form 8-K filed August 31, 2015, File No. 000-54748)
  4.6
  Icagen, Inc. 2018 Stock Incentive Plan (Incorporated by reference to Exhibit B to the Definitive Information Statement on Schedule 14C filed with the Securities and Exchange Commission on December 31, 2018)
  4.7
  Icagen, Inc. Form of Stock Option Agreement under the 2018 Stock Incentive Plan (Incorporated by reference to the Annual Report on Form 10-K for the year ended December 31, 2018, File No. 000-54748)
  4.8*
  Icagen, Inc. Form of Restricted Stock Agreement under the 2018 Stock Incentive Plan
  4.9*
  Icagen, Inc. Form of Restricted Stock Unit Award Agreement under the 2018 Stock Incentive Plan
  5.1*
  Opinion of Gracin & Marlow, LLP
  23.1*
  Consent of RBSM, LLP, Independent Registered Public Accounting Firm
  23.2*
  Consent of Gracin & Marlow, LLP (included in Exhibit 5.1)
  24.1*
  Power of Attorney (included as part of the signature page to this Registration Statement and incorporated herein by reference)
  * Filed herewith.
  II-
  5