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  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">As filed with the Securities and Exchange Commission
  on August 9, 2023</P>
  <P STYLE="margin: 0"></P>
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: right">Registration No. 333-_______</P>
  <P STYLE="margin: 0"></P>
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  <P STYLE="font: 14pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>UNITED STATES</B></P>
  
  <P STYLE="font: 14pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>SECURITIES AND EXCHANGE COMMISSION</B></P>
  
  <P STYLE="font: 12pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>Washington, DC 20549</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
  
  <P STYLE="font: 18pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>FORM S-8</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>REGISTRATION STATEMENT</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>UNDER</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>THE SECURITIES ACT OF 1933</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
  
  <P STYLE="font: 24pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>Aquestive Therapeutics, Inc.</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">(Exact name of registrant as specified in its charter)</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
  
  <table cellspacing="0" cellpadding="0" style="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
    <TR>
      <TD STYLE="vertical-align: bottom; width: 34%; font-size: 10pt; text-align: center"><FONT STYLE="font-size: 10pt"><B>Delaware</B></FONT></TD>
      <TD STYLE="vertical-align: top; width: 33%">
      <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>30 Technology Drive</B></P>
      <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>Warren, NJ 07059</B></P></TD>
      <TD STYLE="vertical-align: bottom; width: 33%; font-size: 10pt; text-align: center"><FONT STYLE="font-size: 10pt"><B>82-3827296</B></FONT></TD></TR>
    <TR STYLE="vertical-align: top">
      <TD STYLE="font-size: 10pt; text-align: center"><FONT STYLE="font-size: 10pt">(State or Other Jurisdiction of Incorporation or Organization)</FONT></TD>
      <TD>
      <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">(Address of Principal Executive Offices)</P>
      <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">(Zip Code)</P></TD>
      <TD STYLE="font-size: 10pt; text-align: center"><FONT STYLE="font-size: 10pt"><B>(</B>I.R.S. Employer Identification No.)</FONT></TD></TR>
    </TABLE>
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>Aquestive Therapeutics, Inc. 2018 Equity Incentive
  Plan, </B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>as amended</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">(Full title of the plan)</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>A. Ernest Toth, Jr.</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>Chief Financial Officer</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>Aquestive Therapeutics, Inc.</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>30 Technology Drive</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>Warren, NJ 07059</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">(Name and address of agent for service)</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>(908) 941-1900</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">(Telephone number, including area code, of agent
  for service)</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center"><I>Copies of all communications to<B>:</B></I></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center"><I>Lori J. Braender</I></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center"><I>SVP, General Counsel</I></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center"><I>Aquestive Therapeutics, Inc.</I></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center"><I>30 Technology Drive</I></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center"><I>Warren, NJ 07059</I></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center"><I>908-941-1900</I></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; background-color: white">Indicate by check mark
  whether the registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, a smaller reporting company or an
  emerging growth company. See the definitions of &ldquo;large accelerated filer,&rdquo; &ldquo;accelerated filer,&rdquo; &ldquo;smaller
  reporting company,&rdquo; and &ldquo;emerging growth company&rdquo; in Rule 12b-2 of the Exchange Act.</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
  
  <table cellspacing="0" cellpadding="0" style="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
    <TR STYLE="vertical-align: top">
      <TD STYLE="width: 46%; font-size: 10pt; text-align: justify"><FONT STYLE="font-size: 10pt">Large accelerated filer&nbsp;&nbsp;<FONT STYLE="font-family: Wingdings">&uml;</FONT></FONT></TD>
      <TD STYLE="width: 54%; font-size: 10pt; text-align: justify"><FONT STYLE="font-size: 10pt">Accelerated filer&nbsp;&nbsp;<FONT STYLE="font-family: Wingdings">&uml;</FONT></FONT></TD></TR>
    <TR STYLE="vertical-align: top">
      <TD STYLE="font-size: 10pt"><FONT STYLE="font-size: 10pt">Non-accelerated filer&nbsp;&nbsp;<FONT STYLE="font-family: Wingdings">x</FONT></FONT></TD>
      <TD STYLE="font-size: 10pt"><FONT STYLE="font-size: 10pt">Smaller reporting company&nbsp;&nbsp;<FONT STYLE="font-family: Wingdings">x</FONT></FONT></TD></TR>
    <TR STYLE="vertical-align: top">
      <TD STYLE="font-size: 10pt">&nbsp;</TD>
      <TD STYLE="font-size: 10pt"><FONT STYLE="font-size: 10pt">Emerging growth company&nbsp;&nbsp;<FONT STYLE="font-family: Wingdings">x</FONT></FONT></TD></TR>
    </TABLE>
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">If an emerging growth company, indicate by check
  mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting
  standards provided pursuant to Section 7(a)(2)(B) of the Securities Act. <FONT STYLE="font-family: Wingdings">&uml;</FONT></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"></P>
  
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  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>EXPLANATORY NOTE</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.5in">This Registration Statement
  is being filed by Aquestive Therapeutics, Inc. (the &ldquo;Registrant&rdquo;) for the purpose of registering an additional 2,000,000 shares
  of Common Stock, par value $0.001 per share (the &ldquo;Common Stock&rdquo;), available for issuance under the Aquestive Therapeutics,
  Inc. 2018 Equity Incentive Plan, as amended (the &ldquo;2018 Plan&rdquo;), representing an increase of 2,000,000 shares reserved under
  the 2018 Plan, as approved by the Registrant&rsquo;s stockholders at the Registrant&rsquo;s annual meeting of stockholders on June 21,
  2023. The Registrant previously filed with the Securities and Exchange Commission (the &ldquo;Commission&rdquo;) registration statements
  on Form S-8 on July 27, 2018 (SEC File No. 333-226399), January 8, 2021 (SEC File No. 333-251984), January 7, 2022 (SEC File No. 333-251984)
  and January 18, 2023 (SEC File No. 333-269292) (collectively, the &ldquo;Prior Registration Statements&rdquo;) registering shares of Common
  Stock issuable under the 2018 Plan. This Registration Statement relates to securities of the same class as those to which the Prior Registration
  Statements relate and is submitted in accordance with General Instruction E of Form S-8 regarding Registration of Additional Securities.
  Pursuant to General Instruction E of Form S-8, the contents of the Prior Registration Statements are incorporated herein by reference
  and made part of this Registration Statement, except for Items 3 and 8, which are being updated by this Registration Statement below.</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>PART II</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-transform: uppercase; text-align: center"><B>INFORMATION REQUIRED
  IN THE REGISTRATION STATEMENT</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
  
  <P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">Item 3. Incorporation of Documents by Reference.</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.5in">The following documents, as
  originally filed with the Commission by the Registrant, are incorporated herein by reference; provided, however, that any reports or portions
  thereof that are furnished, including under Item 2.02 or Item 7.01 of a Current Report on Form 8-K and any exhibits included with such
  items, shall not be deemed incorporated by reference in this Registration Statement:</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0in"><FONT STYLE="font-family: Times New Roman, Times, Serif">(a)&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</FONT>The
  Registrant&rsquo;s Annual Report on Form 10-K for the fiscal year ended December 31, 2022, filed with the Commission pursuant to the Securities
  Exchange Act of 1934, as amended (the &ldquo;Exchange Act&rdquo;), on March 31, 2023;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0in"><FONT STYLE="font-family: Times New Roman, Times, Serif">(b)&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</FONT>The
  Registrant&rsquo;s Quarterly Report on Form 10-Q for the quarter ended March 31, 2023, filed with the Commission on May 2, 2023;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0in"><FONT STYLE="font-family: Times New Roman, Times, Serif">(c)&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</FONT>The
  Registrant&rsquo;s Quarterly Report on Form 10-Q for the quarter ended June 30, 2023, filed with the Commission on August 7, 2023;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0in"><FONT STYLE="font-family: Times New Roman, Times, Serif">(d)&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</FONT>The
  Registrant&rsquo;s Current Reports on Form 8-K, filed with the Commission on January 3, 2023, January 24, 2023, February 7, 2023, March
  6, 2023, April 13, 2023, May 31, 2023, June 23, 2023, June 29, 2023 and August 2, 2023; and</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0in"><FONT STYLE="font-family: Times New Roman, Times, Serif">(e)&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</FONT>The
  description of the Common Stock contained in the Registrant&rsquo;s Registration Statement on Form 8-A (SEC File No. 001-38599) filed
  with the Commission on July 20, 2018, pursuant to Section 12(b) of the Exchange Act, as updated by the description of the Common Stock
  contained in Exhibit 4.7 to the Registrant&rsquo;s Annual Report on Form 10-K for the fiscal year ended December 31, 2019, filed with
  the Commission on March 11, 2020, including any amendments or reports filed for the purpose of updating such description.</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.5in">All documents subsequently
  filed by the Registrant pursuant to Sections 13(a), 13(c), 14 and 15(d) of the Exchange Act, prior to the filing of a post-effective amendment
  to this Registration Statement that indicates that all securities offered have been sold or which deregisters all securities then remaining
  unsold, shall be deemed to be incorporated herein by reference from the date of filing of such documents; provided, however, that any
  reports or portions thereof that are furnished, including under Item 2.02 or Item 7.01 of a Current Report on Form 8-K and any exhibits
  included with such items, shall not be deemed incorporated by reference in this Registration Statement. Any statement contained herein
  or in a document incorporated by reference in this Registration Statement shall be deemed to be modified or superseded for all purposes
  to the extent that a statement contained in this Registration Statement or in any other subsequently filed document which is incorporated
  by reference herein modifies or replaces such statement. Any such statement so modified or superseded shall not be deemed, except as so
  modified or amended, to constitute a part of this Registration Statement.</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
  
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  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
  
  <P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">Item 8. Exhibits.</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
  
  <table cellspacing="0" cellpadding="0" style="width: 100%; font: 10pt Times New Roman, Times, Serif; border-collapse: collapse">
    <TR STYLE="vertical-align: top">
      <TD STYLE="width: 19%; text-align: justify; font-weight: bold"><U>Exhibit Number</U></TD>
      <TD STYLE="width: 81%; text-align: justify; font-weight: bold"><U>Description of Exhibit</U></TD></TR>
    <TR STYLE="vertical-align: top">
      <TD STYLE="text-align: justify; font-weight: bold">&nbsp;</TD>
      <TD STYLE="text-align: justify; font-weight: bold">&nbsp;</TD></TR>
    <TR STYLE="vertical-align: top; background-color: rgb(204,238,255)">
      <TD STYLE="padding-left: 9pt; text-align: justify; font-weight: bold"><FONT STYLE="font-weight: normal">4.1</FONT></TD>
      <TD STYLE="text-align: justify; font-weight: bold"><A HREF="ex4_1.htm"><FONT STYLE="font-weight: normal">Aquestive Therapeutics, Inc. 2018 Equity Incentive Plan, as amended, filed herewith.</FONT></A></TD></TR>
    <TR STYLE="vertical-align: top; background-color: White">
      <TD STYLE="text-align: justify; font-weight: bold">&nbsp;</TD>
      <TD STYLE="text-align: justify; font-weight: bold">&nbsp;</TD></TR>
    <TR STYLE="vertical-align: top; background-color: rgb(204,238,255)">
      <TD STYLE="padding-left: 9pt; text-align: justify; font-weight: bold"><FONT STYLE="font-weight: normal">5.1</FONT></TD>
      <TD STYLE="text-align: justify; font-weight: bold"><FONT STYLE="font-weight: normal;"><A HREF="ex5_1.htm">Legal Opinion of Lori J. Braender, Senior Vice President, General Counsel, and Corporate Secretary, filed herewith.</A></FONT></TD></TR>
    <TR STYLE="vertical-align: top; background-color: White">
      <TD STYLE="text-align: justify; font-weight: bold">&nbsp;</TD>
      <TD STYLE="text-align: justify; font-weight: bold">&nbsp;</TD></TR>
    <TR STYLE="vertical-align: top; background-color: rgb(204,238,255)">
      <TD STYLE="padding-left: 9pt; text-align: justify; font-weight: bold"><FONT STYLE="font-weight: normal">23.1</FONT></TD>
      <TD STYLE="text-align: justify; font-weight: bold"><FONT STYLE="font-weight: normal"><A HREF="ex23_1.htm">Consent of KPMG LLP, filed herewith.</A></FONT></TD></TR>
    <TR STYLE="vertical-align: top; background-color: White">
      <TD STYLE="text-align: justify; font-weight: bold">&nbsp;</TD>
      <TD STYLE="text-align: justify; font-weight: bold">&nbsp;</TD></TR>
    <TR STYLE="vertical-align: top; background-color: rgb(204,238,255)">
      <TD STYLE="padding-left: 9pt; text-align: justify; font-weight: bold"><FONT STYLE="font-weight: normal">24.1</FONT></TD>
      <TD STYLE="text-align: justify; font-weight: bold"><FONT STYLE="font-weight: normal"><A HREF="#poa">Powers of Attorney, filed herewith (included on the signature page of this Registration Statement under the caption &ldquo;Power of Attorney&rdquo;).</A></FONT></TD></TR>
    <TR STYLE="vertical-align: top; background-color: White">
      <TD STYLE="text-align: justify; font-weight: bold">&nbsp;</TD>
      <TD STYLE="text-align: justify; font-weight: bold">&nbsp;</TD></TR>
    <TR STYLE="vertical-align: top; background-color: rgb(204,238,255)">
      <TD STYLE="padding-left: 9pt; text-align: justify; font-weight: bold"><FONT STYLE="font-weight: normal">107</FONT></TD>
      <TD STYLE="text-align: justify; font-weight: bold"><FONT STYLE="font-weight: normal"><A HREF="ex107.htm">Filing Fee Table, filed herewith.</A></FONT></TD></TR>
    </TABLE>
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
  
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  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-transform: uppercase; text-align: center"><B>SIGNATURES</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.5in">Pursuant to the requirements
  of the Securities Act of 1933, as amended, the Registrant certifies that it has reasonable grounds to believe that it meets all of the
  requirements for filing on Form S-8 and has duly caused this Registration Statement to be signed on its behalf by the undersigned, thereunto
  duly authorized, in the County of Somerset, State of New Jersey, on this 9<SUP>th</SUP> day of August, 2023.</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
  
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    <TR STYLE="vertical-align: top">
      <TD>&nbsp;</TD>
      <TD COLSPAN="2"><FONT STYLE="font-size: 10pt">AQUESTIVE THERAPEUTICS, INC.</FONT></TD></TR>
    <TR STYLE="vertical-align: top">
      <TD>&nbsp;</TD>
      <TD COLSPAN="2">&nbsp;</TD></TR>
    <TR STYLE="vertical-align: top">
      <TD STYLE="width: 45%">&nbsp;</TD>
      <TD STYLE="width: 5%"><FONT STYLE="font-size: 10pt">By:</FONT></TD>
      <TD STYLE="width: 50%; border-bottom: black 1pt solid"><FONT STYLE="font-size: 10pt">/s/ Daniel R. Barber</FONT></TD></TR>
    <TR STYLE="vertical-align: top">
      <TD>&nbsp;</TD>
      <TD><FONT STYLE="font-size: 10pt">Name:</FONT></TD>
      <TD STYLE="text-align: justify"><FONT STYLE="font-size: 10pt">Daniel R. Barber</FONT></TD></TR>
    <TR STYLE="vertical-align: top">
      <TD>&nbsp;</TD>
      <TD><FONT STYLE="font-size: 10pt">Title:</FONT></TD>
      <TD STYLE="text-align: justify"><FONT STYLE="font-size: 10pt">President and Chief Executive Officer</FONT></TD></TR>
    </TABLE>
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
  
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  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-transform: uppercase; text-align: center"><B><A NAME="poa"></A>POWER OF ATTORNEY</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.5in">KNOW TO ALL PERSONS BY THESE
  PRESENTS, that each person whose signature appears below constitutes and appoints Daniel R. Barber, A. Ernest Toth, Jr. and Lori J. Braender,
  and each or any one of them, as such person&rsquo;s true and lawful attorney-in-fact and agent, with full power of substitution and resubstitution,
  for such person and in such person&rsquo;s name, place and stead, in any and all capacities, to sign any and all amendments (including
  post-effective amendments) to this Registration Statement and to file the same, with all exhibits thereto, with the Commission, granting
  unto such attorneys-in-fact and agents, and each of them, full power and authority to do and perform each and every act and thing requisite
  and necessary in connection with such matters and hereby ratifying and confirming all that each such attorney-in-fact, or his agent or
  substitutes, may do or cause to be done by virtue hereof.</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.5in">Pursuant to the requirements
  of the Securities Act of 1933, as amended, this Registration Statement has been signed by the following persons in the capacities and
  on the dates indicated:</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
  
  <table cellspacing="0" cellpadding="0" style="width: 100%; font: 10pt Times New Roman, Times, Serif; border-collapse: collapse">
    <TR STYLE="vertical-align: top">
      <TD STYLE="width: 33%; text-align: center"><FONT STYLE="font-size: 10pt"><B>Signature</B></FONT></TD>
      <TD STYLE="width: 36%; text-align: center"><FONT STYLE="font-size: 10pt"><B>Title</B></FONT></TD>
      <TD STYLE="width: 31%; text-align: center"><FONT STYLE="font-size: 10pt"><B>Date</B></FONT></TD></TR>
    <TR STYLE="vertical-align: top">
      <TD STYLE="text-align: center">&nbsp;</TD>
      <TD STYLE="text-align: center">&nbsp;</TD>
      <TD STYLE="text-align: center">&nbsp;</TD></TR>
    <TR STYLE="vertical-align: top">
      <TD STYLE="border-bottom: Black 1pt solid; text-align: center"><FONT STYLE="font-size: 10pt">/s/ Daniel R. Barber</FONT></TD>
      <TD STYLE="text-align: center">&nbsp;</TD>
      <TD STYLE="text-align: center"><FONT STYLE="font-size: 10pt">August 9, 2023</FONT></TD></TR>
    <TR STYLE="vertical-align: top">
      <TD STYLE="text-align: center"><FONT STYLE="font-size: 10pt">Daniel R. Barber</FONT></TD>
      <TD STYLE="text-align: center"><FONT STYLE="font-size: 10pt">President, Chief Executive Officer and Member of the Board of Directors<BR>
  (Principal Executive Officer)</FONT></TD>
      <TD STYLE="text-align: center">&nbsp;</TD></TR>
    <TR STYLE="vertical-align: top">
      <TD STYLE="border-bottom: Black 1pt solid; text-align: center"><FONT STYLE="font-size: 10pt">/s/ A. Ernest Toth, Jr.</FONT></TD>
      <TD STYLE="text-align: center">&nbsp;</TD>
      <TD STYLE="text-align: center"><FONT STYLE="font-size: 10pt">August 9, 2023</FONT></TD></TR>
    <TR STYLE="vertical-align: top">
      <TD STYLE="text-align: center"><FONT STYLE="font-size: 10pt">A. Ernest Toth, Jr.</FONT></TD>
      <TD STYLE="text-align: center"><FONT STYLE="font-size: 10pt">Chief Financial Officer <BR>
  (Principal Financial Officer and Principal Accounting Officer)</FONT></TD>
      <TD STYLE="text-align: center">&nbsp;</TD></TR>
    <TR STYLE="vertical-align: top">
      <TD STYLE="text-align: center">&nbsp;</TD>
      <TD STYLE="text-align: center">&nbsp;</TD>
      <TD STYLE="text-align: center">&nbsp;</TD></TR>
    <TR STYLE="vertical-align: top">
      <TD STYLE="border-bottom: Black 1pt solid; text-align: center"><FONT STYLE="font-size: 10pt">/s/ Santo J. Costa</FONT></TD>
      <TD STYLE="text-align: center">&nbsp;</TD>
      <TD STYLE="text-align: center"><FONT STYLE="font-size: 10pt">August 9, 2023</FONT></TD></TR>
    <TR STYLE="vertical-align: top">
      <TD STYLE="text-align: center"><FONT STYLE="font-size: 10pt">Santo J. Costa</FONT></TD>
      <TD STYLE="text-align: center"><FONT STYLE="font-size: 10pt">Chairman of the Board of Directors</FONT></TD>
      <TD STYLE="text-align: center">&nbsp;</TD></TR>
    <TR STYLE="vertical-align: top">
      <TD STYLE="text-align: center">&nbsp;</TD>
      <TD STYLE="text-align: center">&nbsp;</TD>
      <TD STYLE="text-align: center">&nbsp;</TD></TR>
    <TR STYLE="vertical-align: top">
      <TD STYLE="border-bottom: Black 1pt solid; text-align: center"><FONT STYLE="font-size: 10pt">/s/ Gregory B. Brown, M.D.</FONT></TD>
      <TD STYLE="text-align: center">&nbsp;</TD>
      <TD STYLE="text-align: center"><FONT STYLE="font-size: 10pt">August 9, 2023</FONT></TD></TR>
    <TR STYLE="vertical-align: top">
      <TD STYLE="text-align: center"><FONT STYLE="font-size: 10pt">Gregory B. Brown, M.D.</FONT></TD>
      <TD STYLE="text-align: center"><FONT STYLE="font-size: 10pt">Member of the Board of Directors</FONT></TD>
      <TD STYLE="text-align: center">&nbsp;</TD></TR>
    <TR STYLE="vertical-align: top">
      <TD STYLE="text-align: center">&nbsp;</TD>
      <TD STYLE="text-align: center">&nbsp;</TD>
      <TD STYLE="text-align: center">&nbsp;</TD></TR>
    <TR STYLE="vertical-align: top">
      <TD STYLE="border-bottom: Black 1pt solid; text-align: center"><FONT STYLE="font-size: 10pt">/s/ John Cochran</FONT></TD>
      <TD STYLE="text-align: center">&nbsp;</TD>
      <TD STYLE="text-align: center"><FONT STYLE="font-size: 10pt">August 9, 2023</FONT></TD></TR>
    <TR STYLE="vertical-align: top">
      <TD STYLE="text-align: center"><FONT STYLE="font-size: 10pt">John Cochran</FONT></TD>
      <TD STYLE="text-align: center"><FONT STYLE="font-size: 10pt">Member of the Board of Directors</FONT></TD>
      <TD STYLE="text-align: center">&nbsp;</TD></TR>
    <TR STYLE="vertical-align: top">
      <TD STYLE="text-align: center">&nbsp;</TD>
      <TD STYLE="text-align: center">&nbsp;</TD>
      <TD STYLE="text-align: center">&nbsp;</TD></TR>
    <TR STYLE="vertical-align: top">
      <TD STYLE="border-bottom: Black 1pt solid; text-align: center"><FONT STYLE="font-size: 10pt">/s/ Julie Krop, M.D.</FONT></TD>
      <TD STYLE="text-align: center">&nbsp;</TD>
      <TD STYLE="text-align: center"><FONT STYLE="font-size: 10pt">August 9, 2023</FONT></TD></TR>
    <TR STYLE="vertical-align: top">
      <TD STYLE="text-align: center"><FONT STYLE="font-size: 10pt">Julie Krop, M.D.</FONT></TD>
      <TD STYLE="text-align: center"><FONT STYLE="font-size: 10pt">Member of the Board of Directors</FONT></TD>
      <TD STYLE="text-align: center">&nbsp;</TD></TR>
    <TR STYLE="vertical-align: top">
      <TD STYLE="text-align: center">&nbsp;</TD>
      <TD STYLE="text-align: center">&nbsp;</TD>
      <TD STYLE="text-align: center">&nbsp;</TD></TR>
    <TR STYLE="vertical-align: top">
      <TD STYLE="text-align: center"><FONT STYLE="font-size: 10pt">/s/ Timothy Morris</FONT></TD>
      <TD STYLE="text-align: center">&nbsp;</TD>
      <TD STYLE="text-align: center"><FONT STYLE="font-size: 10pt">August 9, 2023</FONT></TD></TR>
    <TR STYLE="vertical-align: top">
      <TD STYLE="border-top: Black 1pt solid; padding-bottom: 1pt; text-align: center"><FONT STYLE="font-size: 10pt">Timothy Morris</FONT></TD>
      <TD STYLE="padding-bottom: 1pt; text-align: center"><FONT STYLE="font-size: 10pt">Member of the Board of Directors</FONT></TD>
      <TD STYLE="text-align: center; padding-bottom: 1pt">&nbsp;</TD></TR>
    <TR STYLE="vertical-align: top">
      <TD STYLE="text-align: center">&nbsp;</TD>
      <TD STYLE="text-align: center">&nbsp;</TD>
      <TD STYLE="text-align: center">&nbsp;</TD></TR>
    <TR>
      <TD STYLE="border-bottom: Black 1pt solid; vertical-align: top; text-align: center"><FONT STYLE="font-size: 10pt">/s/ Marco Taglietti, M.D.</FONT></TD>
      <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
      <TD STYLE="text-align: center"><FONT STYLE="font-size: 10pt">August 9, 2023</FONT></TD></TR>
    <TR STYLE="vertical-align: top">
      <TD STYLE="text-align: center"><FONT STYLE="font-size: 10pt">Marco Taglietti, M.D.</FONT></TD>
      <TD STYLE="text-align: center"><FONT STYLE="font-size: 10pt">Member of the Board of Directors</FONT></TD>
      <TD STYLE="text-align: center">&nbsp;</TD></TR>
    </TABLE>
  
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metadata_documents: [{"type": "S-8", "sequence": "1", "filename": "e89231s8.htm", "secsgml_size_bytes": 34139}]
metadata_filer: {"company-data": {"conformed-name": "Aquestive Therapeutics, Inc.", "cik": "0001398733", "assigned-sic": "2834", "irs-number": "208623253", "state-of-incorporation": "DE", "fiscal-year-end": "1231"}, "filing-values": {"form-type": "S-8", "act": "33", "file-number": "333-273857", "film-number": "231156344"}, "business-address": {"street1": "30 TECHNOLOGY DRIVE", "city": "WARREN", "state": "NJ", "zip": "07059", "phone": "908-941-1900"}, "mail-address": {"street1": "30 TECHNOLOGY DRIVE", "city": "WARREN", "state": "NJ", "zip": "07059"}, "former-company": {"former-conformed-name": "MonoSol Rx, Inc.", "date-changed": "20070507"}}
text: As filed with the Securities and Exchange Commission
  on August 9, 2023
  Registration No. 333-_______
  UNITED STATES
  SECURITIES AND EXCHANGE COMMISSION
  Washington, DC 20549
  FORM S-8
  REGISTRATION STATEMENT
  UNDER
  THE SECURITIES ACT OF 1933
  Aquestive Therapeutics, Inc.
  (Exact name of registrant as specified in its charter)
  Delaware
  30 Technology Drive
  Warren, NJ 07059
  82-3827296
  (State or Other Jurisdiction of Incorporation or Organization)
  (Address of Principal Executive Offices)
  (Zip Code)
  (
  I.R.S. Employer Identification No.)
  Aquestive Therapeutics, Inc. 2018 Equity Incentive
  Plan,
  as amended
  (Full title of the plan)
  A. Ernest Toth, Jr.
  Chief Financial Officer
  Aquestive Therapeutics, Inc.
  30 Technology Drive
  Warren, NJ 07059
  (Name and address of agent for service)
  (908) 941-1900
  (Telephone number, including area code, of agent
  for service)
  Copies of all communications to
  :
  Lori J. Braender
  SVP, General Counsel
  Aquestive Therapeutics, Inc.
  30 Technology Drive
  Warren, NJ 07059
  908-941-1900
  Indicate by check mark
  whether the registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, a smaller reporting company or an
  emerging growth company. See the definitions of "large accelerated filer," "accelerated filer," "smaller
  reporting company," and "emerging growth company" in Rule 12b-2 of the Exchange Act.
  Large accelerated filer
  ¨
  Accelerated filer
  ¨
  Non-accelerated filer
  x
  Smaller reporting company
  x
  Emerging growth company
  x
  If an emerging growth company, indicate by check
  mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting
  standards provided pursuant to Section 7(a)(2)(B) of the Securities Act.
  ¨
  EXPLANATORY NOTE
  This Registration Statement
  is being filed by Aquestive Therapeutics, Inc. (the "Registrant") for the purpose of registering an additional 2,000,000 shares
  of Common Stock, par value $0.001 per share (the "Common Stock"), available for issuance under the Aquestive Therapeutics,
  Inc. 2018 Equity Incentive Plan, as amended (the "2018 Plan"), representing an increase of 2,000,000 shares reserved under
  the 2018 Plan, as approved by the Registrant's stockholders at the Registrant's annual meeting of stockholders on June 21,
  2023. The Registrant previously filed with the Securities and Exchange Commission (the "Commission") registration statements
  on Form S-8 on July 27, 2018 (SEC File No. 333-226399), January 8, 2021 (SEC File No. 333-251984), January 7, 2022 (SEC File No. 333-251984)
  and January 18, 2023 (SEC File No. 333-269292) (collectively, the "Prior Registration Statements") registering shares of Common
  Stock issuable under the 2018 Plan. This Registration Statement relates to securities of the same class as those to which the Prior Registration
  Statements relate and is submitted in accordance with General Instruction E of Form S-8 regarding Registration of Additional Securities.
  Pursuant to General Instruction E of Form S-8, the contents of the Prior Registration Statements are incorporated herein by reference
  and made part of this Registration Statement, except for Items 3 and 8, which are being updated by this Registration Statement below.
  PART II
  INFORMATION REQUIRED
  IN THE REGISTRATION STATEMENT
  Item 3. Incorporation of Documents by Reference.
  The following documents, as
  originally filed with the Commission by the Registrant, are incorporated herein by reference; provided, however, that any reports or portions
  thereof that are furnished, including under Item 2.02 or Item 7.01 of a Current Report on Form 8-K and any exhibits included with such
  items, shall not be deemed incorporated by reference in this Registration Statement:
  (a)
  The
  Registrant's Annual Report on Form 10-K for the fiscal year ended December 31, 2022, filed with the Commission pursuant to the Securities
  Exchange Act of 1934, as amended (the "Exchange Act"), on March 31, 2023;
  (b)
  The
  Registrant's Quarterly Report on Form 10-Q for the quarter ended March 31, 2023, filed with the Commission on May 2, 2023;
  (c)
  The
  Registrant's Quarterly Report on Form 10-Q for the quarter ended June 30, 2023, filed with the Commission on August 7, 2023;
  (d)
  The
  Registrant's Current Reports on Form 8-K, filed with the Commission on January 3, 2023, January 24, 2023, February 7, 2023, March
  6, 2023, April 13, 2023, May 31, 2023, June 23, 2023, June 29, 2023 and August 2, 2023; and
  (e)
  The
  description of the Common Stock contained in the Registrant's Registration Statement on Form 8-A (SEC File No. 001-38599) filed
  with the Commission on July 20, 2018, pursuant to Section 12(b) of the Exchange Act, as updated by the description of the Common Stock
  contained in Exhibit 4.7 to the Registrant's Annual Report on Form 10-K for the fiscal year ended December 31, 2019, filed with
  the Commission on March 11, 2020, including any amendments or reports filed for the purpose of updating such description.
  All documents subsequently
  filed by the Registrant pursuant to Sections 13(a), 13(c), 14 and 15(d) of the Exchange Act, prior to the filing of a post-effective amendment
  to this Registration Statement that indicates that all securities offered have been sold or which deregisters all securities then remaining
  unsold, shall be deemed to be incorporated herein by reference from the date of filing of such documents; provided, however, that any
  reports or portions thereof that are furnished, including under Item 2.02 or Item 7.01 of a Current Report on Form 8-K and any exhibits
  included with such items, shall not be deemed incorporated by reference in this Registration Statement. Any statement contained herein
  or in a document incorporated by reference in this Registration Statement shall be deemed to be modified or superseded for all purposes
  to the extent that a statement contained in this Registration Statement or in any other subsequently filed document which is incorporated
  by reference herein modifies or replaces such statement. Any such statement so modified or superseded shall not be deemed, except as so
  modified or amended, to constitute a part of this Registration Statement.
  Item 8. Exhibits.
  Exhibit Number
  Description of Exhibit
  4.1
  Aquestive Therapeutics, Inc. 2018 Equity Incentive Plan, as amended, filed herewith.
  5.1
  Legal Opinion of Lori J. Braender, Senior Vice President, General Counsel, and Corporate Secretary, filed herewith.
  23.1
  Consent of KPMG LLP, filed herewith.
  24.1
  Powers of Attorney, filed herewith (included on the signature page of this Registration Statement under the caption "Power of Attorney").
  107
  Filing Fee Table, filed herewith.
  SIGNATURES
  Pursuant to the requirements
  of the Securities Act of 1933, as amended, the Registrant certifies that it has reasonable grounds to believe that it meets all of the
  requirements for filing on Form S-8 and has duly caused this Registration Statement to be signed on its behalf by the undersigned, thereunto
  duly authorized, in the County of Somerset, State of New Jersey, on this 9
  th
  day of August, 2023.
  AQUESTIVE THERAPEUTICS, INC.
  By:
  /s/ Daniel R. Barber
  Name:
  Daniel R. Barber
  Title:
  President and Chief Executive Officer
  POWER OF ATTORNEY
  KNOW TO ALL PERSONS BY THESE
  PRESENTS, that each person whose signature appears below constitutes and appoints Daniel R. Barber, A. Ernest Toth, Jr. and Lori J. Braender,
  and each or any one of them, as such person's true and lawful attorney-in-fact and agent, with full power of substitution and resubstitution,
  for such person and in such person's name, place and stead, in any and all capacities, to sign any and all amendments (including
  post-effective amendments) to this Registration Statement and to file the same, with all exhibits thereto, with the Commission, granting
  unto such attorneys-in-fact and agents, and each of them, full power and authority to do and perform each and every act and thing requisite
  and necessary in connection with such matters and hereby ratifying and confirming all that each such attorney-in-fact, or his agent or
  substitutes, may do or cause to be done by virtue hereof.
  Pursuant to the requirements
  of the Securities Act of 1933, as amended, this Registration Statement has been signed by the following persons in the capacities and
  on the dates indicated:
  Signature
  Title
  Date
  /s/ Daniel R. Barber
  August 9, 2023
  Daniel R. Barber
  President, Chief Executive Officer and Member of the Board of Directors
  (Principal Executive Officer)
  /s/ A. Ernest Toth, Jr.
  August 9, 2023
  A. Ernest Toth, Jr.
  Chief Financial Officer
  (Principal Financial Officer and Principal Accounting Officer)
  /s/ Santo J. Costa
  August 9, 2023
  Santo J. Costa
  Chairman of the Board of Directors
  /s/ Gregory B. Brown, M.D.
  August 9, 2023
  Gregory B. Brown, M.D.
  Member of the Board of Directors
  /s/ John Cochran
  August 9, 2023
  John Cochran
  Member of the Board of Directors
  /s/ Julie Krop, M.D.
  August 9, 2023
  Julie Krop, M.D.
  Member of the Board of Directors
  /s/ Timothy Morris
  August 9, 2023
  Timothy Morris
  Member of the Board of Directors
  /s/ Marco Taglietti, M.D.
  August 9, 2023
  Marco Taglietti, M.D.
  Member of the Board of Directors