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  <P STYLE="text-align: center; margin-top: 0; margin-bottom: 0"><B>As filed with the Securities and Exchange Commission on December 15, 2023</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: right"><B>Registration No. 333-</B>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</P>
  
  <!-- Field: Rule-Page --><DIV STYLE="margin-top: 0pt; margin-bottom: 0pt; width: 100%"><DIV STYLE="font-size: 1pt; border-top: Black 2pt solid; border-bottom: Black 1pt solid">&nbsp;</DIV></DIV><!-- Field: /Rule-Page -->
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>&nbsp;</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>UNITED STATES</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>SECURITIES AND EXCHANGE COMMISSION</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>Washington, D.C. 20549</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>FORM S-8</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>REGISTRATION STATEMENT</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>UNDER</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>THE SECURITIES ACT OF 1933</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><FONT STYLE="font-variant: small-caps"><B>NeuroOne
  Medical Technologies Corporation</B></FONT></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">(Exact name of registrant as specified in its charter)</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>
  
  <TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
    <TR STYLE="vertical-align: top">
      <TD STYLE="border-bottom: black 1.5pt solid; padding: 0.25pt 0.5pt 0.75pt; text-align: center; width: 49%"><FONT STYLE="font-size: 10pt"><B>Delaware</B></FONT></TD>
      <TD STYLE="padding: 0.25pt 0.5pt 1.75pt; width: 2%">&nbsp;</TD>
      <TD STYLE="border-bottom: black 1.5pt solid; padding: 0.25pt 0.5pt 0.75pt; text-align: center; width: 49%"><FONT STYLE="font-size: 10pt"><B>27-0863354</B></FONT></TD></TR>
    <TR STYLE="vertical-align: top">
      <TD STYLE="padding: 0.25pt 0.5pt; text-align: center"><FONT STYLE="font-size: 10pt">(State or other jurisdiction of<BR>
  incorporation or organization)</FONT></TD>
      <TD STYLE="padding: 0.25pt 0.5pt">&nbsp;</TD>
      <TD STYLE="padding: 0.25pt 0.5pt; text-align: center"><FONT STYLE="font-size: 10pt">(I.R.S. Employer<BR>
  Identification Number.)</FONT></TD></TR>
    </TABLE>
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
  
  <TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
    <TR STYLE="vertical-align: bottom">
      <TD STYLE="border-bottom: black 1.5pt solid; padding: 0.25pt 0.5pt 0.75pt; text-align: center; width: 49%"><FONT STYLE="font-size: 10pt"><B>7599 Anagram Dr., <BR>
  Eden Prairie, MN </B></FONT></TD>
      <TD STYLE="padding: 0.25pt 0.5pt 1.75pt; width: 2%">&nbsp;</TD>
      <TD STYLE="border-bottom: black 1.5pt solid; padding: 0.25pt 0.5pt 0.75pt; text-align: center; width: 49%"><FONT STYLE="font-size: 10pt"><B>55344</B></FONT></TD></TR>
    <TR STYLE="vertical-align: top">
      <TD STYLE="padding: 0.25pt 0.5pt; text-align: center"><FONT STYLE="font-size: 10pt">(Address of principal executive offices) </FONT></TD>
      <TD STYLE="padding: 0.25pt 0.5pt">&nbsp;</TD>
      <TD STYLE="padding: 0.25pt 0.5pt; text-align: center"><FONT STYLE="font-size: 10pt">(Zip code)</FONT></TD></TR>
    </TABLE>
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5pt; text-align: center"><B>NeuroOne Medical Technologies Corporation
  2021 Inducement Plan</B></P>
  
  <!-- Field: Rule-Page --><DIV STYLE="margin-top: 0pt; margin-bottom: 0pt; width: 100%"><DIV STYLE="font-size: 1pt; border-top: Black 1.5pt solid">&nbsp;</DIV></DIV><!-- Field: /Rule-Page -->
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5pt; text-align: center">(Full title of the plan)</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5pt; text-align: center">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>David Rosa</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>President and Chief Executive Officer</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>NeuroOne Medical Technologies Corporation</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>7599 Anagram Dr.,<BR>
  Eden Prairie, MN 55344</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>952-426-1383</B></P>
  
  <!-- Field: Rule-Page --><DIV STYLE="margin-top: 0pt; margin-bottom: 0pt; width: 100%"><DIV STYLE="font-size: 1pt; border-top: Black 1.5pt solid">&nbsp;</DIV></DIV><!-- Field: /Rule-Page -->
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">(Name, address, and telephone number, including
  area code, of agent for service)</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>Copy to:</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>Phillip D. Torrence, Esq.</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>Emily Johns, Esq.</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>Honigman LLP</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>650 Trade Centre Way, Suite 200</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>Kalamazoo, Michigan 49002-0402</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>(269) 337-7700</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">Indicate by check mark whether the registrant
  is a large accelerated filer, an accelerated filer, a non-accelerated filer, a smaller reporting company or an emerging growth company.
  See the definitions of &ldquo;large accelerated filer,&rdquo; &ldquo;accelerated filer,&rdquo; &ldquo;smaller reporting company,&rdquo;
  and &ldquo;emerging growth company&rdquo; in Rule 12b-2 of the Exchange Act.</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>
  
  <TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%">
    <TR STYLE="vertical-align: top">
      <TD><FONT STYLE="font-size: 10pt">Large accelerated filer <FONT STYLE="font-family: Times New Roman, Times, Serif">&#9744;</FONT></FONT></TD>
      <TD STYLE="padding-left: 10pt; text-indent: -10pt"><FONT STYLE="font-size: 10pt">Accelerated filer <FONT STYLE="font-family: Times New Roman, Times, Serif">&#9744;</FONT></FONT></TD></TR>
    <TR STYLE="vertical-align: top">
      <TD><FONT STYLE="font-size: 10pt">Non-accelerated filer <FONT STYLE="font-family: Times New Roman, Times, Serif">&#9746;</FONT></FONT></TD>
      <TD STYLE="padding-left: 10pt; text-indent: -10pt"><FONT STYLE="font-size: 10pt">Smaller reporting company <FONT STYLE="font-family: Times New Roman, Times, Serif">&#9746;</FONT></FONT></TD></TR>
    <TR STYLE="vertical-align: top">
      <TD>&nbsp;</TD>
      <TD STYLE="padding-left: 10pt; text-indent: -10pt"><FONT STYLE="font-size: 10pt">Emerging growth company <FONT STYLE="font-family: Times New Roman, Times, Serif">&#9744;</FONT></FONT></TD></TR>
    </TABLE>
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">If an emerging growth company, indicate by check
  mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting
  standards provided pursuant to Section 7(a)(2)(B) of the Securities Act. <FONT STYLE="font-family: Times New Roman, Times, Serif">&#9744;</FONT></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"></P>
  
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  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"></P>
  
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      <DIV STYLE="margin-top: 12pt; margin-bottom: 6pt; border-bottom: Black 1.5pt solid"><P STYLE="margin: 0pt">&nbsp;</P></DIV>
      <DIV STYLE="break-before: page; margin-top: 6pt; margin-bottom: 12pt"><P STYLE="margin: 0pt">&nbsp;</P></DIV>
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  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center"><B>EXPLANATORY NOTE</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center">&nbsp;</P>
  
  <P STYLE="text-align: justify; font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">This Registration Statement on Form S-8 is being
  filed by NeuroOne Medical Technologies Corporation, a Delaware corporation. (the &ldquo;<B><I>Company</I></B>&rdquo; or &ldquo;<B><I>Registrant</I></B>&rdquo;)
  for the purpose of registering an additional 150,000 shares of the Registrant&rsquo;s common stock, $0.001 par value (the <B><I>&ldquo;Common
  Stock&rdquo;</I></B>) issuable pursuant to the Registrant&rsquo;s 2021 Inducement Plan (the &ldquo;<B><I>Inducement Plan</I></B>&rdquo;).</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
  
  <P STYLE="text-align: justify; font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">Pursuant to General Instruction E to Form S-8,
  this Registration Statement is being filed for the purpose of increasing the number of securities of the same class as other securities
  for which a Registration Statement of the Company on Form S-8 relating to the Inducement Plan is effective, and the Company&rsquo;s Registration
  Statements on Form S-8 previously filed with the Securities and Exchange Commission (the &ldquo;<B><I>Commission</I></B>&rdquo;) on November 23, 2021 (File No. 333-261302) registering shares of Common Stock issuable under the Inducement Plan are incorporated by reference in
  this Registration Statement.</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; background-color: white">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; background-color: white"></P>
  
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  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; background-color: white">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center"><B>PART II</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center"><B>&nbsp;</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center"><B>INFORMATION REQUIRED IN THE REGISTRATION STATEMENT</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B>&nbsp;</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B>Item 3. Incorporation of Documents by Reference.</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.5in">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.5in">The following documents filed
  with the Commission by the Registrant are hereby incorporated by reference in this Registration Statement:</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.5in">&nbsp;</P>
  
  <TABLE CELLPADDING="0" CELLSPACING="0" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; width: 100%"><TR STYLE="vertical-align: top; text-align: justify">
  <TD STYLE="width: 0in"></TD><TD STYLE="width: 0.5in; text-align: left"><FONT STYLE="font-size: 10pt">(a)</FONT></TD><TD STYLE="text-align: justify"><FONT STYLE="font-size: 10pt">our Annual Report on Form 10-K
  for the year ended September 30, 2023 filed with the Commission on <A HREF="https://www.sec.gov/ix?doc=/Archives/edgar/data/1500198/000121390023096120/f10k2023_neuroone.htm" STYLE="-sec-extract: exhibit">December 15, 2023</A>;</FONT></TD>
  </TR></TABLE>
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
  
  <TABLE CELLPADDING="0" CELLSPACING="0" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; width: 100%"><TR STYLE="vertical-align: top; text-align: justify">
  <TD STYLE="width: 0in"></TD><TD STYLE="width: 0.5in; text-align: left">(b)</TD><TD STYLE="text-align: justify"><FONT STYLE="font-size: 10pt">our Current Reports on Form
  8-K filed with the Commission on <A HREF="http://www.sec.gov/Archives/edgar/data/1500198/000121390023084013/ea187820-8k_neuroone.htm">November 7, 2023</A>; <A HREF="http://www.sec.gov/Archives/edgar/data/1500198/000121390023087126/ea188259-8k_neuroone.htm">November 14, 2023</A>, <A HREF="http://www.sec.gov/Archives/edgar/data/1500198/000121390023087723/ea188543-8k_neuroone.htm">November 16, 2023</A>; and <A HREF="http://www.sec.gov/Archives/edgar/data/1500198/000121390023094562/ea189752-8k_neuroone.htm">December 11, 2023</A>; and</FONT></TD>
  </TR></TABLE>
  
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
  
  <TABLE CELLPADDING="0" CELLSPACING="0" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; width: 100%"><TR STYLE="vertical-align: top; text-align: justify">
  <TD STYLE="width: 0in"></TD><TD STYLE="width: 0.5in; text-align: left"><FONT STYLE="font-size: 10pt">(c)</FONT></TD><TD STYLE="text-align: justify"><FONT STYLE="font-size: 10pt">the description of our Common
  Stock in our registration statement on <A HREF="http://www.sec.gov/Archives/edgar/data/1500198/000121390021028934/ea141508-8a12b_neuroone.htm">Form 8-A</A> filed with the SEC on May 25, 2021 and as amended by any subsequent amendment or report
  filed for the purpose of updating such description.</FONT></TD>
  </TR></TABLE>
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
  
  <P STYLE="text-align: justify; font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">In addition, all documents the Registrant subsequently
  files pursuant to Sections 13(a), 13(c), 14 or 15(d) of the Exchange Act after the filing of this Registration Statement and prior to
  the filing of a post-effective amendment which indicates that all securities offered hereby have been sold or which deregisters all securities
  covered hereby then remaining unsold are incorporated by reference in this Registration Statement and are a part hereof from the date
  of filing of such documents. Notwithstanding anything herein, the Registrant is not incorporating by reference any information furnished
  under Item 2.02 or Item 7.01 of any Current Report on Form 8-K, unless, and to the extent, specified in any such Current Report on Form
  8-K.</P>
  
  <P STYLE="text-align: justify; font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
  
  <P STYLE="text-align: justify; font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">Any statement herein or contained in a document
  incorporated or deemed to be incorporated by reference herein shall be deemed to be modified or superseded for purposes of this Registration
  Statement to the extent that a statement contained herein, or in any subsequently filed document, which also is or is deemed to be incorporated
  by reference herein, modifies or supersedes such prior statement. Any such statement so modified or superseded shall not be deemed, except
  as so modified or superseded, to constitute part of this Registration Statement.</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.5in">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.5in"></P>
  
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  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.5in">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B>Item 8. Exhibits.</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>EXHIBIT INDEX</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">The following exhibits are filed as part of this registration statement.</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>&nbsp;</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>INDEX TO EXHIBITS</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>
  
  <TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; background-color: white; border-collapse: collapse">
    <TR>
      <TD STYLE="vertical-align: bottom; border-bottom: black 1.5pt solid; padding: 0.25pt 0.5pt 0.75pt; width: 9%">
      <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B>Exhibit<BR>
  Number</B></P></TD>
      <TD STYLE="padding: 0.25pt 0.5pt; width: 1%">&nbsp;</TD>
      <TD STYLE="border-bottom: black 1.5pt solid; vertical-align: bottom; padding: 0.25pt 0.5pt 0.75pt; text-align: justify; width: 90%"><FONT STYLE="font-size: 10pt"><B>Description</B></FONT></TD></TR>
    <TR STYLE="background-color: rgb(204,238,255)">
      <TD STYLE="vertical-align: top; padding: 0.25pt 0.5pt"><FONT STYLE="font-size: 10pt">4.1</FONT></TD>
      <TD STYLE="padding: 0.25pt 0.5pt">&nbsp;</TD>
      <TD STYLE="text-align: justify; vertical-align: bottom; padding: 0.25pt 0.5pt 1pt"><FONT STYLE="font-size: 10pt"><A HREF="http://www.sec.gov/Archives/edgar/data/1500198/000114420417034948/v470040_ex3-4.htm">Certificate of Incorporation of NeuroOne Medical Technologies Corporation (incorporated by reference to Exhibit 3.4 on the Registrant&rsquo;s Current Report on Form 8-K filed on June, 29, 2017)</A></FONT></TD></TR>
    <TR STYLE="background-color: White">
      <TD STYLE="vertical-align: top; padding: 0.25pt 0.5pt">&nbsp;</TD>
      <TD STYLE="padding: 0.25pt 0.5pt">&nbsp;</TD>
      <TD STYLE="text-align: justify; vertical-align: bottom; padding: 0.25pt 0.5pt">&nbsp;</TD></TR>
    <TR STYLE="background-color: rgb(204,238,255)">
      <TD STYLE="vertical-align: top; padding: 0.25pt 0.5pt"><FONT STYLE="font-size: 10pt">4.2</FONT></TD>
      <TD STYLE="padding: 0.25pt 0.5pt">&nbsp;</TD>
      <TD STYLE="text-align: justify; vertical-align: bottom; padding: 0.25pt 0.5pt 1pt"><FONT STYLE="font-size: 10pt"><A HREF="http://www.sec.gov/Archives/edgar/data/1500198/000121390021018989/ea138690ex3-1_neuroone.htm">Certificate of Amendment to Amended and Restated Certificate of Incorporation of NeuroOne Medical Technologies Corporation (incorporated by reference to Exhibit 3.1 on the Registrant&rsquo;s Current Report on Form 8-K filed on March 31, 2021)</A></FONT></TD></TR>
    <TR STYLE="background-color: White">
      <TD STYLE="vertical-align: top; padding: 0.25pt 0.5pt">&nbsp;</TD>
      <TD STYLE="padding: 0.25pt 0.5pt">&nbsp;</TD>
      <TD STYLE="text-align: justify; vertical-align: bottom; padding: 0.25pt 0.5pt">&nbsp;</TD></TR>
    <TR STYLE="background-color: rgb(204,238,255)">
      <TD STYLE="vertical-align: top; padding: 0.25pt 0.5pt"><FONT STYLE="font-size: 10pt">4.3</FONT></TD>
      <TD STYLE="padding: 0.25pt 0.5pt">&nbsp;</TD>
      <TD STYLE="text-align: justify; vertical-align: top; padding: 0.25pt 0.5pt 1pt"><FONT STYLE="font-size: 10pt"><A HREF="http://www.sec.gov/Archives/edgar/data/1500198/000114420417034948/v470040_ex3-5.htm">Bylaws of NeuroOne Medical Technologies Corporation (incorporated by reference to Exhibit 3.5 on the Registrant&rsquo;s Current Report on Form 8-K filed on June 29, 2017)</A></FONT></TD></TR>
    <TR STYLE="background-color: White">
      <TD STYLE="vertical-align: top; padding: 0.25pt 0.5pt">&nbsp;</TD>
      <TD STYLE="padding: 0.25pt 0.5pt">&nbsp;</TD>
      <TD STYLE="text-align: justify; vertical-align: bottom; padding: 0.25pt 0.5pt">&nbsp;</TD></TR>
    <TR STYLE="background-color: rgb(204,238,255)">
      <TD STYLE="vertical-align: top; padding: 0.25pt 0.5pt"><FONT STYLE="font-size: 10pt">4.4</FONT></TD>
      <TD STYLE="padding: 0.25pt 0.5pt">&nbsp;</TD>
      <TD STYLE="text-align: justify; vertical-align: bottom; padding: 0.25pt 0.5pt 1pt"><FONT STYLE="font-size: 10pt"><A HREF="http://www.sec.gov/Archives/edgar/data/1500198/000101376221000094/ea148325ex10-1_neuroone.htm">NeuroOne Medical Technologies Corporation 2021 Inducement Plan (incorporated by reference to Exhibit 10.1 on the Registrant&rsquo;s Current Report on Form 8-K filed on October 4, 2021)</A></FONT></TD></TR>
    <TR STYLE="background-color: White">
      <TD STYLE="vertical-align: top; padding: 0.25pt 0.5pt">&nbsp;</TD>
      <TD STYLE="padding: 0.25pt 0.5pt">&nbsp;</TD>
      <TD STYLE="text-align: justify; vertical-align: bottom; padding: 0.25pt 0.5pt 1pt">&nbsp;</TD></TR>
    <TR STYLE="background-color: rgb(204,238,255)">
      <TD STYLE="vertical-align: top; padding: 0.25pt 0.5pt"><FONT STYLE="font-size: 10pt">4.5</FONT></TD>
      <TD STYLE="padding: 0.25pt 0.5pt">&nbsp;</TD>
      <TD STYLE="text-align: justify; vertical-align: bottom; padding: 0.25pt 0.5pt 1pt"><FONT STYLE="font-size: 10pt"><A HREF="http://www.sec.gov/Archives/edgar/data/1500198/000121390023087126/ea188259ex10-2_neuroone.htm">First Amendment to NeuroOne Medical Technologies Corporation 2021 Inducement Plan (incorporated by reference to Exhibit 10.2 on the Registrant&rsquo;s Current Report on Form 8-K filed on November 14, 2023)</A></FONT></TD></TR>
    <TR STYLE="background-color: White">
      <TD STYLE="vertical-align: top; padding: 0.25pt 0.5pt">&nbsp;</TD>
      <TD STYLE="padding: 0.25pt 0.5pt">&nbsp;</TD>
      <TD STYLE="text-align: justify; vertical-align: bottom; padding: 0.25pt 0.5pt">&nbsp;</TD></TR>
    <TR STYLE="background-color: rgb(204,238,255)">
      <TD STYLE="vertical-align: top; padding: 0.25pt 0.5pt"><FONT STYLE="font-size: 10pt">5.1</FONT></TD>
      <TD STYLE="padding: 0.25pt 0.5pt">&nbsp;</TD>
      <TD STYLE="text-align: justify; vertical-align: bottom; padding: 0.25pt 0.5pt 1pt"><FONT STYLE="font-size: 10pt"><A HREF="ea190055ex5-1_neuroone.htm">Opinion of Honigman LLP</A></FONT></TD></TR>
    <TR STYLE="background-color: White">
      <TD STYLE="vertical-align: top; padding: 0.25pt 0.5pt">&nbsp;</TD>
      <TD STYLE="padding: 0.25pt 0.5pt">&nbsp;</TD>
      <TD STYLE="text-align: justify; vertical-align: bottom; padding: 0.25pt 0.5pt 1pt">&nbsp;</TD></TR>
    <TR STYLE="background-color: rgb(204,238,255)">
      <TD STYLE="vertical-align: top; padding: 0.25pt 0.5pt"><FONT STYLE="font-size: 10pt">23.1</FONT></TD>
      <TD STYLE="padding: 0.25pt 0.5pt">&nbsp;</TD>
      <TD STYLE="text-align: justify; vertical-align: bottom; padding: 0.25pt 0.5pt 1pt"><FONT STYLE="font-size: 10pt"><A HREF="ea190055ex23-1_neuroone.htm">Consent of Baker Tilly US, LLP</A></FONT></TD></TR>
    <TR STYLE="background-color: White">
      <TD STYLE="vertical-align: top; padding: 0.25pt 0.5pt">&nbsp;</TD>
      <TD STYLE="padding: 0.25pt 0.5pt">&nbsp;</TD>
      <TD STYLE="text-align: justify; vertical-align: bottom; padding: 0.25pt 0.5pt">&nbsp;</TD></TR>
    <TR STYLE="background-color: rgb(204,238,255)">
      <TD STYLE="vertical-align: top; padding: 0.25pt 0.5pt"><FONT STYLE="font-size: 10pt">23.2</FONT></TD>
      <TD STYLE="padding: 0.25pt 0.5pt">&nbsp;</TD>
      <TD STYLE="text-align: justify; vertical-align: bottom; padding: 0.25pt 0.5pt"><FONT STYLE="font-size: 10pt"><A HREF="ea190055ex5-1_neuroone.htm">Consent of Honigman LLP (included in its opinion filed as Exhibit 5.1 to this Registration Statement)</A></FONT></TD></TR>
    <TR STYLE="background-color: White">
      <TD STYLE="vertical-align: top; padding: 0.25pt 0.5pt">&nbsp;</TD>
      <TD STYLE="padding: 0.25pt 0.5pt">&nbsp;</TD>
      <TD STYLE="text-align: justify; vertical-align: bottom; padding: 0.25pt 0.5pt">&nbsp;</TD></TR>
    <TR STYLE="background-color: rgb(204,238,255)">
      <TD STYLE="vertical-align: top; padding: 0.25pt 0.5pt"><FONT STYLE="font-size: 10pt">24.1</FONT></TD>
      <TD STYLE="padding: 0.25pt 0.5pt">&nbsp;</TD>
      <TD STYLE="text-align: justify; vertical-align: bottom; padding: 0.25pt 0.5pt 1pt"><FONT STYLE="font-size: 10pt"><A HREF="#power_001">Power of Attorney (included after the signature of the Registrant contained on the Signature Page of this Registration Statement)</A></FONT></TD></TR>
    <TR STYLE="background-color: White">
      <TD STYLE="vertical-align: top; padding: 0.25pt 0.5pt">&nbsp;</TD>
      <TD STYLE="padding: 0.25pt 0.5pt">&nbsp;</TD>
      <TD STYLE="text-align: justify; vertical-align: bottom; padding: 0.25pt 0.5pt 1pt">&nbsp;</TD></TR>
    <TR STYLE="background-color: rgb(204,238,255)">
      <TD STYLE="vertical-align: top; padding: 0.25pt 0.5pt"><FONT STYLE="font-size: 10pt">107</FONT></TD>
      <TD STYLE="padding: 0.25pt 0.5pt">&nbsp;</TD>
      <TD STYLE="text-align: justify; vertical-align: bottom; padding: 0.25pt 0.5pt 1pt"><FONT STYLE="font-size: 10pt"><A HREF="ea190055ex-fee_neuroone.htm">Filing Fee Table</A></FONT></TD></TR>
    </TABLE>
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"></P>
  
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  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B><A NAME="power_001"></A>SIGNATURES</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>
  
  <P STYLE="text-align: justify; font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Pursuant to the requirements of the Securities Act of 1933, the registrant
  certifies that it has reasonable grounds to believe that it meets all of the requirements for filing on Form S-8 and has duly caused this
  Registration Statement to be signed on its behalf by the undersigned, thereunto duly authorized, in the City of Eden Prairie, State of
  Minnesota, on December 15, 2023.</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>
  
  <TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
    <TR STYLE="vertical-align: top">
      <TD STYLE="padding: 0pt; width: 60%">&nbsp;</TD>
      <TD STYLE="padding: 0pt; width: 40%"><FONT STYLE="font-size: 10pt"><B>NeuroOne Medical Technologies Corporation</B></FONT></TD></TR>
    </TABLE>
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
  
  <TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
    <TR>
      <TD STYLE="padding: 0pt; width: 60%">&nbsp;</TD>
      <TD STYLE="padding: 0pt; vertical-align: top; width: 3%"><FONT STYLE="font-size: 10pt">By:&nbsp;</FONT></TD>
      <TD STYLE="border-bottom: black 1.5pt solid; padding: 0pt; vertical-align: top; width: 37%"><FONT STYLE="font-size: 10pt">/s/ David Rosa</FONT></TD></TR>
    <TR>
      <TD STYLE="padding: 0pt">&nbsp;</TD>
      <TD STYLE="padding: 0pt; vertical-align: top">&nbsp;</TD>
      <TD STYLE="padding: 0pt; vertical-align: top"><FONT STYLE="font-size: 10pt">David Rosa</FONT></TD></TR>
    <TR>
      <TD STYLE="padding: 0pt">&nbsp;</TD>
      <TD STYLE="padding: 0pt; vertical-align: top">&nbsp;</TD>
      <TD STYLE="padding: 0pt; vertical-align: top"><FONT STYLE="font-size: 10pt"><I>President and Chief Executive Officer</I></FONT></TD></TR>
    </TABLE>
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center">&nbsp;<B>&nbsp;</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center"><B>POWER OF ATTORNEY</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center">&nbsp;</P>
  
  <P STYLE="text-align: justify; font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Each person whose signature appears below constitutes and appoints
  David Rosa and Ronald McClurg, or either of them, as his true and lawful attorneys-in-fact and agents, with the full power of substitution
  and resubstitution, for him and in his name, place or stead, in any and all capacities, to sign any and all amendments to this Registration
  Statement (including post-effective amendments), and to file the same, with all exhibits thereto and other documents in connection therewith,
  with the Securities and Exchange Commission, granting unto said attorneys-in-fact and agents, and each of them, full power and authority
  to do and perform each and every act and thing requisite and necessary to be done in connection therewith, as fully to all intents and
  purposes as he might or could do in person, hereby ratifying and confirming all that said attorneys-in-fact and agents, or any of them,
  or their or his substitute or substitutes, may lawfully do or cause to be done by virtue hereof.</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
  
  <P STYLE="text-align: justify; font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Pursuant to the requirements of the Securities Act of 1933, this Registration
  Statement on Form S-8 has been signed by the following persons in the capacities and on the dates indicated.</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>
  
  <TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
    <TR STYLE="vertical-align: top">
      <TD STYLE="width: 36%; border-bottom: black 1.5pt solid; text-align: center"><FONT STYLE="font-size: 10pt"><B>Signature </B></FONT></TD>
      <TD STYLE="width: 2%">&nbsp;</TD>
      <TD STYLE="width: 35%; border-bottom: black 1.5pt solid; text-align: center"><FONT STYLE="font-size: 10pt"><B>Title</B></FONT></TD>
      <TD STYLE="width: 2%">&nbsp;</TD>
      <TD STYLE="width: 21%; border-bottom: black 1.5pt solid; text-align: center"><FONT STYLE="font-size: 10pt"><B>Date</B></FONT></TD></TR>
    <TR STYLE="vertical-align: top">
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD></TR>
    <TR>
      <TD STYLE="vertical-align: bottom; border-bottom: black 1.5pt solid"><FONT STYLE="font-size: 10pt">/s/ David Rosa</FONT></TD>
      <TD STYLE="vertical-align: top">&nbsp;</TD>
      <TD STYLE="vertical-align: bottom"><FONT STYLE="font-size: 10pt">President and Chief Executive Officer</FONT></TD>
      <TD STYLE="vertical-align: top">&nbsp;</TD>
      <TD STYLE="vertical-align: bottom; text-align: center"><FONT STYLE="font-size: 10pt">December 15, 2023</FONT></TD></TR>
    <TR>
      <TD STYLE="vertical-align: bottom"><FONT STYLE="font-size: 10pt">David Rosa</FONT></TD>
      <TD STYLE="vertical-align: top">&nbsp;</TD>
      <TD STYLE="vertical-align: top"><FONT STYLE="font-size: 10pt">(Principal Executive Officer) and a Director</FONT></TD>
      <TD STYLE="vertical-align: top">&nbsp;</TD>
      <TD STYLE="vertical-align: top">&nbsp;</TD></TR>
    <TR>
      <TD STYLE="vertical-align: bottom">&nbsp;</TD>
      <TD STYLE="vertical-align: top">&nbsp;</TD>
      <TD STYLE="vertical-align: top">&nbsp;</TD>
      <TD STYLE="vertical-align: top">&nbsp;</TD>
      <TD STYLE="vertical-align: top">&nbsp;</TD></TR>
    <TR>
      <TD STYLE="vertical-align: bottom; border-bottom: black 1.5pt solid"><FONT STYLE="font-size: 10pt">/s/ Ronald McClurg</FONT></TD>
      <TD STYLE="vertical-align: top">&nbsp;</TD>
      <TD STYLE="vertical-align: bottom"><FONT STYLE="font-size: 10pt">Chief Financial Officer (Principal Financial </FONT></TD>
      <TD STYLE="vertical-align: top">&nbsp;</TD>
      <TD STYLE="vertical-align: bottom; text-align: center"><FONT STYLE="font-size: 10pt">December 15, 2023</FONT></TD></TR>
    <TR>
      <TD STYLE="vertical-align: bottom"><FONT STYLE="font-size: 10pt">Ronald McClurg</FONT></TD>
      <TD STYLE="vertical-align: top">&nbsp;</TD>
      <TD STYLE="vertical-align: top"><FONT STYLE="font-size: 10pt">Officer and Principal Accounting Officer)</FONT></TD>
      <TD STYLE="vertical-align: top">&nbsp;</TD>
      <TD STYLE="vertical-align: top">&nbsp;</TD></TR>
    <TR STYLE="vertical-align: top">
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD></TR>
    <TR>
      <TD STYLE="vertical-align: top; border-bottom: black 1.5pt solid"><FONT STYLE="font-size: 10pt">/s/ Paul Buckman</FONT></TD>
      <TD STYLE="vertical-align: top">&nbsp;</TD>
      <TD STYLE="vertical-align: top"><FONT STYLE="font-size: 10pt">Director</FONT></TD>
      <TD STYLE="vertical-align: top">&nbsp;</TD>
      <TD STYLE="vertical-align: bottom; text-align: center"><FONT STYLE="font-size: 10pt">December 15, 2023</FONT></TD></TR>
    <TR STYLE="vertical-align: top">
      <TD><FONT STYLE="font-size: 10pt">Paul Buckman</FONT></TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD></TR>
    <TR STYLE="vertical-align: top">
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD></TR>
    <TR>
      <TD STYLE="vertical-align: top; border-bottom: black 1.5pt solid"><FONT STYLE="font-size: 10pt">/s/ Jeffrey Mathiesen</FONT></TD>
      <TD STYLE="vertical-align: top">&nbsp;</TD>
      <TD STYLE="vertical-align: top"><FONT STYLE="font-size: 10pt">Director</FONT></TD>
      <TD STYLE="vertical-align: top">&nbsp;</TD>
      <TD STYLE="vertical-align: bottom; text-align: center"><FONT STYLE="font-size: 10pt">December 15, 2023</FONT></TD></TR>
    <TR STYLE="vertical-align: top">
      <TD><FONT STYLE="font-size: 10pt">Jeffrey Mathiesen</FONT></TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD></TR>
    <TR STYLE="vertical-align: top">
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD></TR>
    <TR>
      <TD STYLE="vertical-align: top; border-bottom: black 1.5pt solid"><FONT STYLE="font-size: 10pt">/s/ Edward Andrle</FONT></TD>
      <TD STYLE="vertical-align: top">&nbsp;</TD>
      <TD STYLE="vertical-align: top"><FONT STYLE="font-size: 10pt">Director</FONT></TD>
      <TD STYLE="vertical-align: top">&nbsp;</TD>
      <TD STYLE="vertical-align: bottom; text-align: center"><FONT STYLE="font-size: 10pt">December 15, 2023</FONT></TD></TR>
    <TR STYLE="vertical-align: top">
      <TD><FONT STYLE="font-size: 10pt">Edward Andrle</FONT></TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD></TR>
    </TABLE>
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">II-3</P>
  
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  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>
  
  </BODY>
  </HTML>
metadata_documents: [{"type": "S-8", "sequence": "1", "filename": "ea190055-s8_neuroonemedical.htm", "description": "REGISTRATION STATEMENT", "secsgml_size_bytes": 38459}]
metadata_filer: {"company-data": {"conformed-name": "NEUROONE MEDICAL TECHNOLOGIES Corp", "cik": "0001500198", "assigned-sic": "3841", "irs-number": "270863354", "state-of-incorporation": "DE", "fiscal-year-end": "0930"}, "filing-values": {"form-type": "S-8", "act": "33", "file-number": "333-276079", "film-number": "231491022"}, "business-address": {"street1": "7599 ANAGRAM DR", "city": "EDEN PRAIRIE", "state": "MN", "zip": "55344", "phone": "(952) 426-1383"}, "mail-address": {"street1": "7599 ANAGRAM DR", "city": "EDEN PRAIRIE", "state": "MN", "zip": "55344"}, "former-company": {"former-conformed-name": "Original Source Entertainment, Inc.", "date-changed": "20100830"}}
text: As filed with the Securities and Exchange Commission on December 15, 2023
  Registration No. 333-
  UNITED STATES
  SECURITIES AND EXCHANGE COMMISSION
  Washington, D.C. 20549
  FORM S-8
  REGISTRATION STATEMENT
  UNDER
  THE SECURITIES ACT OF 1933
  NeuroOne
  Medical Technologies Corporation
  (Exact name of registrant as specified in its charter)
  Delaware
  27-0863354
  (State or other jurisdiction of
  incorporation or organization)
  (I.R.S. Employer
  Identification Number.)
  7599 Anagram Dr.,
  Eden Prairie, MN
  55344
  (Address of principal executive offices)
  (Zip code)
  NeuroOne Medical Technologies Corporation
  2021 Inducement Plan
  (Full title of the plan)
  David Rosa
  President and Chief Executive Officer
  NeuroOne Medical Technologies Corporation
  7599 Anagram Dr.,
  Eden Prairie, MN 55344
  952-426-1383
  (Name, address, and telephone number, including
  area code, of agent for service)
  Copy to:
  Phillip D. Torrence, Esq.
  Emily Johns, Esq.
  Honigman LLP
  650 Trade Centre Way, Suite 200
  Kalamazoo, Michigan 49002-0402
  (269) 337-7700
  Indicate by check mark whether the registrant
  is a large accelerated filer, an accelerated filer, a non-accelerated filer, a smaller reporting company or an emerging growth company.
  See the definitions of "large accelerated filer," "accelerated filer," "smaller reporting company,"
  and "emerging growth company" in Rule 12b-2 of the Exchange Act.
  Large accelerated filer
  ☐
  Accelerated filer
  ☐
  Non-accelerated filer
  ☒
  Smaller reporting company
  ☒
  Emerging growth company
  ☐
  If an emerging growth company, indicate by check
  mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting
  standards provided pursuant to Section 7(a)(2)(B) of the Securities Act.
  ☐
  EXPLANATORY NOTE
  This Registration Statement on Form S-8 is being
  filed by NeuroOne Medical Technologies Corporation, a Delaware corporation. (the "
  Company
  " or "
  Registrant
  ")
  for the purpose of registering an additional 150,000 shares of the Registrant's common stock, $0.001 par value (the
  "Common
  Stock"
  ) issuable pursuant to the Registrant's 2021 Inducement Plan (the "
  Inducement Plan
  ").
  Pursuant to General Instruction E to Form S-8,
  this Registration Statement is being filed for the purpose of increasing the number of securities of the same class as other securities
  for which a Registration Statement of the Company on Form S-8 relating to the Inducement Plan is effective, and the Company's Registration
  Statements on Form S-8 previously filed with the Securities and Exchange Commission (the "
  Commission
  ") on November 23, 2021 (File No. 333-261302) registering shares of Common Stock issuable under the Inducement Plan are incorporated by reference in
  this Registration Statement.
  PART II
  INFORMATION REQUIRED IN THE REGISTRATION STATEMENT
  Item 3. Incorporation of Documents by Reference.
  The following documents filed
  with the Commission by the Registrant are hereby incorporated by reference in this Registration Statement:
  (a)
  our Annual Report on Form 10-K
  for the year ended September 30, 2023 filed with the Commission on
  December 15, 2023
  ;
  (b)
  our Current Reports on Form
  8-K filed with the Commission on
  November 7, 2023
  ;
  November 14, 2023
  ,
  November 16, 2023
  ; and
  December 11, 2023
  ; and
  (c)
  the description of our Common
  Stock in our registration statement on
  Form 8-A
  filed with the SEC on May 25, 2021 and as amended by any subsequent amendment or report
  filed for the purpose of updating such description.
  In addition, all documents the Registrant subsequently
  files pursuant to Sections 13(a), 13(c), 14 or 15(d) of the Exchange Act after the filing of this Registration Statement and prior to
  the filing of a post-effective amendment which indicates that all securities offered hereby have been sold or which deregisters all securities
  covered hereby then remaining unsold are incorporated by reference in this Registration Statement and are a part hereof from the date
  of filing of such documents. Notwithstanding anything herein, the Registrant is not incorporating by reference any information furnished
  under Item 2.02 or Item 7.01 of any Current Report on Form 8-K, unless, and to the extent, specified in any such Current Report on Form
  8-K.
  Any statement herein or contained in a document
  incorporated or deemed to be incorporated by reference herein shall be deemed to be modified or superseded for purposes of this Registration
  Statement to the extent that a statement contained herein, or in any subsequently filed document, which also is or is deemed to be incorporated
  by reference herein, modifies or supersedes such prior statement. Any such statement so modified or superseded shall not be deemed, except
  as so modified or superseded, to constitute part of this Registration Statement.
  II-
  1
  Item 8. Exhibits.
  EXHIBIT INDEX
  The following exhibits are filed as part of this registration statement.
  INDEX TO EXHIBITS
  Exhibit
  Number
  Description
  4.1
  Certificate of Incorporation of NeuroOne Medical Technologies Corporation (incorporated by reference to Exhibit 3.4 on the Registrant's Current Report on Form 8-K filed on June, 29, 2017)
  4.2
  Certificate of Amendment to Amended and Restated Certificate of Incorporation of NeuroOne Medical Technologies Corporation (incorporated by reference to Exhibit 3.1 on the Registrant's Current Report on Form 8-K filed on March 31, 2021)
  4.3
  Bylaws of NeuroOne Medical Technologies Corporation (incorporated by reference to Exhibit 3.5 on the Registrant's Current Report on Form 8-K filed on June 29, 2017)
  4.4
  NeuroOne Medical Technologies Corporation 2021 Inducement Plan (incorporated by reference to Exhibit 10.1 on the Registrant's Current Report on Form 8-K filed on October 4, 2021)
  4.5
  First Amendment to NeuroOne Medical Technologies Corporation 2021 Inducement Plan (incorporated by reference to Exhibit 10.2 on the Registrant's Current Report on Form 8-K filed on November 14, 2023)
  5.1
  Opinion of Honigman LLP
  23.1
  Consent of Baker Tilly US, LLP
  23.2
  Consent of Honigman LLP (included in its opinion filed as Exhibit 5.1 to this Registration Statement)
  24.1
  Power of Attorney (included after the signature of the Registrant contained on the Signature Page of this Registration Statement)
  107
  Filing Fee Table
  II-
  2
  SIGNATURES
  Pursuant to the requirements of the Securities Act of 1933, the registrant
  certifies that it has reasonable grounds to believe that it meets all of the requirements for filing on Form S-8 and has duly caused this
  Registration Statement to be signed on its behalf by the undersigned, thereunto duly authorized, in the City of Eden Prairie, State of
  Minnesota, on December 15, 2023.
  NeuroOne Medical Technologies Corporation
  By:
  /s/ David Rosa
  David Rosa
  President and Chief Executive Officer
  POWER OF ATTORNEY
  Each person whose signature appears below constitutes and appoints
  David Rosa and Ronald McClurg, or either of them, as his true and lawful attorneys-in-fact and agents, with the full power of substitution
  and resubstitution, for him and in his name, place or stead, in any and all capacities, to sign any and all amendments to this Registration
  Statement (including post-effective amendments), and to file the same, with all exhibits thereto and other documents in connection therewith,
  with the Securities and Exchange Commission, granting unto said attorneys-in-fact and agents, and each of them, full power and authority
  to do and perform each and every act and thing requisite and necessary to be done in connection therewith, as fully to all intents and
  purposes as he might or could do in person, hereby ratifying and confirming all that said attorneys-in-fact and agents, or any of them,
  or their or his substitute or substitutes, may lawfully do or cause to be done by virtue hereof.
  Pursuant to the requirements of the Securities Act of 1933, this Registration
  Statement on Form S-8 has been signed by the following persons in the capacities and on the dates indicated.
  Signature
  Title
  Date
  /s/ David Rosa
  President and Chief Executive Officer
  December 15, 2023
  David Rosa
  (Principal Executive Officer) and a Director
  /s/ Ronald McClurg
  Chief Financial Officer (Principal Financial
  December 15, 2023
  Ronald McClurg
  Officer and Principal Accounting Officer)
  /s/ Paul Buckman
  Director
  December 15, 2023
  Paul Buckman
  /s/ Jeffrey Mathiesen
  Director
  December 15, 2023
  Jeffrey Mathiesen
  /s/ Edward Andrle
  Director
  December 15, 2023
  Edward Andrle
  II-3