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  <div style="TEXT-ALIGN: right; FONT-FAMILY: 'Times New Roman', Times, serif; COLOR: #000000; FONT-SIZE: 10pt; FONT-WEIGHT: bold">Registration No.&#160;333-&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;</div>
  
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  <div style="TEXT-ALIGN: center; FONT-FAMILY: 'Times New Roman', Times, serif; COLOR: #000000; FONT-SIZE: 14pt; FONT-WEIGHT: bold">REGISTRATION STATEMENT</div>
  
  <div style="TEXT-ALIGN: center; FONT-STYLE: italic; FONT-FAMILY: 'Times New Roman', Times, serif; COLOR: #000000; FONT-SIZE: 10pt; FONT-WEIGHT: bold">UNDER</div>
  
  <div style="TEXT-ALIGN: center; FONT-STYLE: italic; FONT-FAMILY: 'Times New Roman', Times, serif; COLOR: #000000; FONT-SIZE: 10pt; FONT-WEIGHT: bold">THE SECURITIES ACT OF 1933</div>
  
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  <div style="TEXT-ALIGN: center; FONT-VARIANT: normal; FONT-STYLE: normal; FONT-FAMILY: 'Times New Roman', Times, serif; COLOR: #000000; FONT-SIZE: 24pt; FONT-WEIGHT: bold">Midatech Pharma PLC</div>
  
  <div style="TEXT-ALIGN: center; FONT-FAMILY: 'Times New Roman', Times, serif; COLOR: #000000; FONT-SIZE: 10pt; FONT-WEIGHT: bold">(Exact name of registrant as specified in its charter)</div>
  
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  <div style="TEXT-ALIGN: center; FONT-FAMILY: 'Times New Roman', Times, serif; COLOR: #000000; FONT-SIZE: 10pt; FONT-WEIGHT: bold">(State or Other Jurisdiction of</div>
  
  <div style="TEXT-ALIGN: center; FONT-FAMILY: 'Times New Roman', Times, serif; COLOR: #000000; FONT-SIZE: 10pt; FONT-WEIGHT: bold">Incorporation or Organization)</div>
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  <div style="TEXT-ALIGN: center; FONT-FAMILY: 'Times New Roman', Times, serif; COLOR: #000000; FONT-SIZE: 10pt; FONT-WEIGHT: bold">(IRS Employer</div>
  
  <div style="TEXT-ALIGN: center; FONT-FAMILY: 'Times New Roman', Times, serif; COLOR: #000000; FONT-SIZE: 10pt; FONT-WEIGHT: bold">Identification No.)</div>
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  <div style="TEXT-ALIGN: center; FONT-FAMILY: 'Times New Roman', Times, serif; COLOR: #000000; FONT-SIZE: 10pt; FONT-WEIGHT: bold">65 Innovation Drive</div>
  
  <div style="TEXT-ALIGN: center; FONT-FAMILY: 'Times New Roman', Times, serif; COLOR: #000000; FONT-SIZE: 10pt; FONT-WEIGHT: bold">Milton Park</div>
  
  <div style="TEXT-ALIGN: center; FONT-FAMILY: 'Times New Roman', Times, serif; COLOR: #000000; FONT-SIZE: 10pt; FONT-WEIGHT: bold">Abingdon, Oxfordshire, OX14 4RQ, United Kingdom</div>
  
  <div style="TEXT-ALIGN: center; FONT-FAMILY: 'Times New Roman', Times, serif; COLOR: #000000; FONT-SIZE: 10pt; FONT-WEIGHT: bold">Tel: +44 (0)1235 841 575</div>
  
  <div style="TEXT-ALIGN: center; FONT-FAMILY: 'Times New Roman', Times, serif; COLOR: #000000; FONT-SIZE: 10pt; FONT-WEIGHT: bold">(Address, including zip code, and telephone number, including area code, of registrant&#8217;s principal executive offices)</div>
  
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  <div style="TEXT-ALIGN: center; FONT-FAMILY: 'Times New Roman', Times, serif; COLOR: #000000; FONT-SIZE: 14pt; FONT-WEIGHT: bold">Midatech Pharma PLC 2016 U.S. Option Plan</div>
  
  <div style="TEXT-ALIGN: center; FONT-FAMILY: 'Times New Roman', Times, serif; COLOR: #000000; FONT-SIZE: 10pt; FONT-WEIGHT: bold">(Full title of the plans)</div>
  
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  <div style="TEXT-ALIGN: center; FONT-FAMILY: 'Times New Roman', Times, serif; COLOR: #000000; FONT-SIZE: 10pt; FONT-WEIGHT: bold">Midatech Pharma PLC</div>
  
  <div style="TEXT-ALIGN: center; FONT-FAMILY: 'Times New Roman', Times, serif; COLOR: #000000; FONT-SIZE: 10pt; FONT-WEIGHT: bold">Attn: John C. Petrolino</div>
  
  <div style="TEXT-ALIGN: center; FONT-FAMILY: 'Times New Roman', Times, serif; COLOR: #000000; FONT-SIZE: 10pt; FONT-WEIGHT: bold">8601 Six Forks Road, Suite 160</div>
  
  <div style="TEXT-ALIGN: center; FONT-FAMILY: 'Times New Roman', Times, serif; COLOR: #000000; FONT-SIZE: 10pt; FONT-WEIGHT: bold">Raleigh, North Carolina 25414</div>
  
  <div style="TEXT-ALIGN: center; FONT-FAMILY: 'Times New Roman', Times, serif; COLOR: #000000; FONT-SIZE: 10pt; FONT-WEIGHT: bold">(Name, address, including zip code, and telephone number, including area code, of agent for service)</div>
  
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  <div style="TEXT-ALIGN: center; FONT-STYLE: italic; FONT-FAMILY: 'Times New Roman', Times, serif; COLOR: #000000; FONT-SIZE: 10pt; FONT-WEIGHT: bold">Copies of communications to:</div>
  
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  <div style="TEXT-ALIGN: center; FONT-FAMILY: 'Times New Roman', Times, serif; COLOR: #000000; FONT-SIZE: 10pt; FONT-WEIGHT: bold">R. Douglas Harmon, Esq.</div>
  
  <div style="TEXT-ALIGN: center; FONT-FAMILY: 'Times New Roman', Times, serif; COLOR: #000000; FONT-SIZE: 10pt; FONT-WEIGHT: bold">Michel Vanesse, Esq.</div>
  
  <div style="TEXT-ALIGN: center; FONT-FAMILY: 'Times New Roman', Times, serif; COLOR: #000000; FONT-SIZE: 10pt; FONT-WEIGHT: bold">Parker Poe Adams &amp; Bernstein LLP</div>
  
  <div style="TEXT-ALIGN: center; FONT-FAMILY: 'Times New Roman', Times, serif; COLOR: #000000; FONT-SIZE: 10pt; FONT-WEIGHT: bold">Three Wells Fargo Center</div>
  
  <div style="TEXT-ALIGN: center; FONT-FAMILY: 'Times New Roman', Times, serif; COLOR: #000000; FONT-SIZE: 10pt; FONT-WEIGHT: bold">401 South Tryon Street, Suite 3000</div>
  
  <div style="TEXT-ALIGN: center; FONT-FAMILY: 'Times New Roman', Times, serif; COLOR: #000000; FONT-SIZE: 10pt; FONT-WEIGHT: bold">Charlotte, NC 28202</div>
  
  <div style="TEXT-ALIGN: center; FONT-FAMILY: 'Times New Roman', Times, serif; COLOR: #000000; FONT-SIZE: 10pt; FONT-WEIGHT: bold">T: (704) 372-9000</div>
  
  <div style="TEXT-ALIGN: center; FONT-FAMILY: 'Times New Roman', Times, serif; COLOR: #000000; FONT-SIZE: 10pt; FONT-WEIGHT: bold">F: (704) 334-4706</div>
  
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  <div style="TEXT-ALIGN: left; FONT-FAMILY: 'Times New Roman', Times, serif; COLOR: #000000; FONT-SIZE: 10pt">Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, or a smaller reporting company. See the definitions of &#8220;large accelerated filer,&#8221; &#8220;accelerated filer&#8221; and &#8220;smaller reporting company&#8221; in Rule 12b-2 of the Exchange Act (Check one):</div>
  
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  <div style="TEXT-ALIGN: left; FONT-FAMILY: 'Times New Roman', Times, serif; COLOR: #000000; FONT-SIZE: 10pt">Large&#160;accelerated&#160;filer</div>
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  <div style="TEXT-ALIGN: left; FONT-FAMILY: 'Times New Roman', Times, serif; COLOR: #000000; FONT-SIZE: 10pt">Accelerated&#160;filer</div>
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  <div style="TEXT-ALIGN: left; FONT-FAMILY: 'Times New Roman', Times, serif; COLOR: #000000; FONT-SIZE: 10pt">Non-accelerated filer</div>
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  <div style="TEXT-ALIGN: left; FONT-FAMILY: 'Times New Roman', Times, serif; COLOR: #000000; FONT-SIZE: 10pt">&#9745;&#160;(Do not check if a smaller reporting company)</div>
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  <div style="TEXT-ALIGN: left; FONT-FAMILY: 'Times New Roman', Times, serif; COLOR: #000000; FONT-SIZE: 10pt">Smaller&#160;reporting&#160;company</div>
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  <div style="TEXT-ALIGN: left; FONT-FAMILY: 'Times New Roman', Times, serif; COLOR: #000000; FONT-SIZE: 10pt">&#9744;</div>
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  <div style="TEXT-ALIGN: center; FONT-FAMILY: 'Times New Roman', Times, serif; COLOR: #000000; FONT-SIZE: 10pt; FONT-WEIGHT: bold">CALCULATION OF REGISTRATION FEE</div>
  
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  <td style="WIDTH: 13.43%; WHITE-SPACE: nowrap; VERTICAL-ALIGN: bottom; BORDER-TOP: #000000 2px solid">&#160;</td>
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  <div style="TEXT-ALIGN: center; FONT-FAMILY: 'Times New Roman', Times, serif; COLOR: #000000; FONT-SIZE: 10pt; FONT-WEIGHT: bold">Title of securities to be registered</div>
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  <div style="TEXT-ALIGN: left; FONT-FAMILY: 'Times New Roman', Times, serif; COLOR: #000000; FONT-SIZE: 10pt">&#160;</div>
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  <td style="WIDTH: 13.43%; WHITE-SPACE: nowrap; VERTICAL-ALIGN: bottom; BORDER-TOP: #000000 2px solid">
  <div style="TEXT-ALIGN: center; FONT-FAMILY: 'Times New Roman', Times, serif; COLOR: #000000; FONT-SIZE: 10pt; FONT-WEIGHT: bold">Amount<font style="FONT-FAMILY: 'Times New Roman', Times, serif; FONT-SIZE: 10pt"><br>
  </font>to be<font style="FONT-FAMILY: 'Times New Roman', Times, serif; FONT-SIZE: 10pt"><br>
  </font> registered&#160;(1)(2)(3)</div>
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  <div style="TEXT-ALIGN: left; FONT-FAMILY: 'Times New Roman', Times, serif; COLOR: #000000; FONT-SIZE: 10pt">&#160;</div>
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  <div style="TEXT-ALIGN: center; FONT-FAMILY: 'Times New Roman', Times, serif; COLOR: #000000; FONT-SIZE: 10pt; FONT-WEIGHT: bold">Proposed</div>
  
  <div style="TEXT-ALIGN: center; FONT-FAMILY: 'Times New Roman', Times, serif; COLOR: #000000; FONT-SIZE: 10pt; FONT-WEIGHT: bold">maximum</div>
  
  <div style="TEXT-ALIGN: center; FONT-FAMILY: 'Times New Roman', Times, serif; COLOR: #000000; FONT-SIZE: 10pt; FONT-WEIGHT: bold">offering price</div>
  
  <div style="TEXT-ALIGN: center; FONT-FAMILY: 'Times New Roman', Times, serif; COLOR: #000000; FONT-SIZE: 10pt; FONT-WEIGHT: bold">per share&#160;(4)</div>
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  <div style="TEXT-ALIGN: left; FONT-FAMILY: 'Times New Roman', Times, serif; COLOR: #000000; FONT-SIZE: 10pt">&#160;</div>
  </td>
  <td style="WIDTH: 13.43%; WHITE-SPACE: nowrap; VERTICAL-ALIGN: bottom; BORDER-TOP: #000000 2px solid">
  <div style="TEXT-ALIGN: center; FONT-FAMILY: 'Times New Roman', serif; COLOR: #000000; FONT-SIZE: 1pt; FONT-WEIGHT: bold"><font style="FONT-FAMILY: 'Times New Roman', Times, serif; FONT-SIZE: 10pt">Proposed</font><font style="FONT-FAMILY: 'Times New Roman', serif; FONT-SIZE: 1pt"><br>
  </font><font style="FONT-FAMILY: 'Times New Roman', Times, serif; FONT-SIZE: 10pt">maximum</font></div>
  
  <div style="TEXT-ALIGN: center; FONT-FAMILY: 'Times New Roman', Times, serif; COLOR: #000000; FONT-SIZE: 10pt; FONT-WEIGHT: bold">aggregate</div>
  
  <div style="TEXT-ALIGN: center; FONT-FAMILY: 'Times New Roman', Times, serif; COLOR: #000000; FONT-SIZE: 10pt; FONT-WEIGHT: bold">offering price</div>
  </td>
  <td style="BORDER-LEFT: #000000 2px solid; WIDTH: 1.3%; VERTICAL-ALIGN: bottom; BORDER-TOP: #000000 2px solid">
  <div style="TEXT-ALIGN: left; FONT-FAMILY: 'Times New Roman', Times, serif; COLOR: #000000; FONT-SIZE: 10pt">&#160;</div>
  </td>
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  <div style="TEXT-ALIGN: center; FONT-FAMILY: 'Times New Roman', Times, serif; COLOR: #000000; FONT-SIZE: 10pt; FONT-WEIGHT: bold">Amount of<font style="FONT-FAMILY: 'Times New Roman', Times, serif; FONT-SIZE: 10pt"><br>
  </font> registration fee</div>
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  <div style="TEXT-ALIGN: left; FONT-FAMILY: 'Times New Roman', Times, serif; COLOR: #000000; MARGIN-LEFT: 8.5pt; FONT-SIZE: 10pt">Ordinary shares, nominal value 0.005p per share, to be</div>
  
  <div style="TEXT-ALIGN: left; FONT-FAMILY: 'Times New Roman', Times, serif; COLOR: #000000; FONT-SIZE: 10pt">
  <div style="TEXT-ALIGN: left; FONT-FAMILY: 'Times New Roman', Times, serif; COLOR: #000000; MARGIN-LEFT: 9pt; FONT-SIZE: 10pt">issued under the Midatech Pharma PLC 2016 U.S.</div>
  
  <div style="TEXT-ALIGN: left; FONT-FAMILY: 'Times New Roman', Times, serif; COLOR: #000000; MARGIN-LEFT: 9pt; FONT-SIZE: 10pt">Option Plan</div>
  </div>
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  <td style="BORDER-LEFT: #000000 2px solid; WIDTH: 1.3%; VERTICAL-ALIGN: bottom; BORDER-TOP: #000000 2px solid">&#160;</td>
  <td style="WIDTH: 13.43%; WHITE-SPACE: nowrap; VERTICAL-ALIGN: bottom; BORDER-TOP: #000000 2px solid">
  <div style="TEXT-ALIGN: center; FONT-FAMILY: 'Times New Roman', Times, serif; COLOR: #000000; FONT-SIZE: 10pt">1,000,000</div>
  </td>
  <td style="BORDER-LEFT: #000000 2px solid; WIDTH: 1.3%; VERTICAL-ALIGN: bottom; BORDER-TOP: #000000 2px solid">&#160;</td>
  <td style="WIDTH: 13.43%; WHITE-SPACE: nowrap; VERTICAL-ALIGN: bottom; BORDER-TOP: #000000 2px solid">
  <div style="TEXT-ALIGN: center; FONT-FAMILY: 'Times New Roman', Times, serif; COLOR: #000000; FONT-SIZE: 10pt">$1.54</div>
  </td>
  <td style="BORDER-LEFT: #000000 2px solid; WIDTH: 1.3%; VERTICAL-ALIGN: bottom; BORDER-TOP: #000000 2px solid">&#160;</td>
  <td style="WIDTH: 13.43%; WHITE-SPACE: nowrap; VERTICAL-ALIGN: bottom; BORDER-TOP: #000000 2px solid">
  <div style="TEXT-ALIGN: center; FONT-FAMILY: 'Times New Roman', Times, serif; COLOR: #000000; FONT-SIZE: 10pt">$1,540,000</div>
  </td>
  <td style="BORDER-LEFT: #000000 2px solid; WIDTH: 1.3%; VERTICAL-ALIGN: bottom; BORDER-TOP: #000000 2px solid">&#160;</td>
  <td style="WIDTH: 13.43%; WHITE-SPACE: nowrap; VERTICAL-ALIGN: bottom; BORDER-TOP: #000000 2px solid">
  <div style="TEXT-ALIGN: center; FONT-FAMILY: 'Times New Roman', Times, serif; COLOR: #000000; FONT-SIZE: 10pt">$178.49</div>
  </td>
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  <td style="BORDER-BOTTOM: #000000 2px solid; BORDER-LEFT: #000000 2px solid; WIDTH: 1.3%; VERTICAL-ALIGN: bottom; BORDER-TOP: #000000 2px solid">&#160;</td>
  <td style="BORDER-BOTTOM: #000000 2px solid; WIDTH: 13.43%; VERTICAL-ALIGN: bottom; BORDER-TOP: #000000 2px solid">&#160;</td>
  <td style="BORDER-BOTTOM: #000000 2px solid; BORDER-LEFT: #000000 2px solid; WIDTH: 1.3%; VERTICAL-ALIGN: bottom; BORDER-TOP: #000000 2px solid">&#160;</td>
  <td style="BORDER-BOTTOM: #000000 2px solid; WIDTH: 13.43%; VERTICAL-ALIGN: bottom; BORDER-TOP: #000000 2px solid">&#160;</td>
  <td style="BORDER-BOTTOM: #000000 2px solid; BORDER-LEFT: #000000 2px solid; WIDTH: 1.3%; VERTICAL-ALIGN: bottom; BORDER-TOP: #000000 2px solid">&#160;</td>
  <td style="BORDER-BOTTOM: #000000 2px solid; WIDTH: 13.43%; VERTICAL-ALIGN: bottom; BORDER-TOP: #000000 2px solid">&#160;</td>
  <td style="BORDER-BOTTOM: #000000 2px solid; BORDER-LEFT: #000000 2px solid; WIDTH: 1.3%; VERTICAL-ALIGN: bottom; BORDER-TOP: #000000 2px solid">&#160;</td>
  <td style="BORDER-BOTTOM: #000000 2px solid; WIDTH: 13.43%; VERTICAL-ALIGN: bottom; BORDER-TOP: #000000 2px solid">&#160;</td>
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  <br>
  </div>
  
  <div><br>
  </div>
  
  <div style="TEXT-ALIGN: left">
  <table style="WIDTH: 100%; FONT-FAMILY: 'Times New Roman', Times, serif; FONT-SIZE: 10pt" id="ze8e5fd5639434c9b8054aa2d7b8a091f" class="DSPFListTable" cellspacing="0" cellpadding="0">
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  <td style="WIDTH: 18pt; FONT-FAMILY: 'Times New Roman', Times, serif; COLOR: #000000; FONT-SIZE: 10pt; VERTICAL-ALIGN: top; align: right">(1)</td>
  <td style="TEXT-ALIGN: left; WIDTH: auto; FONT-FAMILY: 'Times New Roman', Times, serif; COLOR: #000000; FONT-SIZE: 10pt; VERTICAL-ALIGN: top">Represents the maximum number of ordinary shares, nominal value 0.005p per share (the &#8220;Ordinary Shares&#8221;), of Midatech Pharma PLC (the &#8220;Company&#8221;) issuable under outstanding option awards granted under the Midatech Pharma PLC 2016 U.S. Option Plan (the &#8220;Plan&#8221;).</td>
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  </div>
  
  <div><br>
  </div>
  
  <div style="TEXT-ALIGN: left">
  <table style="WIDTH: 100%; FONT-FAMILY: 'Times New Roman', Times, serif; FONT-SIZE: 10pt" id="zdbdbbb4a4f6347b4af9dad818638dcc0" class="DSPFListTable" cellspacing="0" cellpadding="0">
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  <td style="WIDTH: 18pt; FONT-FAMILY: 'Times New Roman', Times, serif; COLOR: #000000; FONT-SIZE: 10pt; VERTICAL-ALIGN: top; align: right">(2)</td>
  <td style="TEXT-ALIGN: left; WIDTH: auto; FONT-FAMILY: 'Times New Roman', Times, serif; COLOR: #000000; FONT-SIZE: 10pt; VERTICAL-ALIGN: top">The Ordinary Shares of Midatech may be represented by Midatech&#8217;s American Depositary Shares (&#8220;ADS&#8221;), evidenced by American Depositary Receipts, each representing two Ordinary Shares. A separate Registration Statement on Form F-6&#160; (File No. 333-207186) was filed with the Securities and Exchange Commission on September 29, 2015, as amended on October 27, 2015, for the registration of ADSs evidenced by American Depositary Receipts issuable upon deposit of Ordinary Shares.</td>
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  </div>
  
  <div><br>
  </div>
  
  <div style="TEXT-ALIGN: left">
  <table style="WIDTH: 100%; FONT-FAMILY: 'Times New Roman', Times, serif; FONT-SIZE: 10pt" id="z40a64e9353114b2191cd66e03ce64ee9" class="DSPFListTable" cellspacing="0" cellpadding="0">
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  <td style="WIDTH: 18pt; FONT-FAMILY: 'Times New Roman', Times, serif; COLOR: #000000; FONT-SIZE: 10pt; VERTICAL-ALIGN: top; align: right">(3)</td>
  <td style="TEXT-ALIGN: left; WIDTH: auto; FONT-FAMILY: 'Times New Roman', Times, serif; COLOR: #000000; FONT-SIZE: 10pt; VERTICAL-ALIGN: top">Pursuant to Rule 416(a) under the Securities Act of 1933, as amended (the &#8220;Securities Act&#8221;), the number of Ordinary Shares registered includes an indeterminable number of Ordinary Shares as required to prevent dilution resulting from a stock split, stock dividend or similar transaction that results in an increase in the number of outstanding Ordinary Shares.</td>
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  <div><br>
  </div>
  
  <div style="TEXT-ALIGN: left">
  <table style="WIDTH: 100%; FONT-FAMILY: 'Times New Roman', Times, serif; FONT-SIZE: 10pt" id="z99ea9077eed7437082e9255e5754e70d" class="DSPFListTable" cellspacing="0" cellpadding="0">
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  <td style="WIDTH: 18pt; FONT-FAMILY: 'Times New Roman', Times, serif; COLOR: #000000; FONT-SIZE: 10pt; VERTICAL-ALIGN: top; align: right">(4)</td>
  <td style="TEXT-ALIGN: left; FONT-VARIANT: normal; FONT-STYLE: normal; WIDTH: auto; FONT-FAMILY: 'Times New Roman', Times, serif; COLOR: #000000; FONT-SIZE: 10pt; VERTICAL-ALIGN: top; FONT-WEIGHT: normal">Estimated solely for the purposes of calculating the registration fee. Such estimate has been computed in accordance with Rule 457(c) and 457(h) under the Securities Act, based on the average of the high and low quotation for Ordinary Shares on the AIM Market of the London Stock Exchange plc on December 2, 2016, and the buying rate for British pounds sterling of &#163;1.00=$1.2685 based on noon buying rates published by the Federal Reserve Bank of New York for British pounds sterling on December 2, 2016.</td>
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  <div>&#160;</div>
  
  <div>
  <hr style="BORDER-BOTTOM: black 4px solid; TEXT-ALIGN: center; BACKGROUND-COLOR: #ffffff; HEIGHT: 10px; COLOR: #ffffff; MARGIN-LEFT: auto; BORDER-TOP: black 1px solid; MARGIN-RIGHT: auto" align="center">
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  <div>&#160;</div>
  
  <div style="MARGIN-TOP: 10pt; MARGIN-BOTTOM: 10pt; CLEAR: both" id="DSPFPageBreakArea">
  <div style="TEXT-ALIGN: center" id="DSPFPageNumberArea"><font style="FONT-STYLE: normal; FONT-FAMILY: 'Times New Roman'; FONT-SIZE: 10pt; FONT-WEIGHT: normal" id="DSPFPageNumber">2</font></div>
  
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  <div>&#160;</div>
  
  <div style="TEXT-ALIGN: center; FONT-FAMILY: 'Times New Roman', Times, serif; COLOR: #000000; FONT-SIZE: 10pt; FONT-WEIGHT: bold">PART I</div>
  
  <div>&#160;</div>
  
  <div style="TEXT-ALIGN: center; FONT-FAMILY: 'Times New Roman', Times, serif; COLOR: #000000; FONT-SIZE: 10pt; FONT-WEIGHT: bold">INFORMATION REQUIRED IN THE SECTION 10(a) PROSPECTUS</div>
  
  <div>&#160;</div>
  
  <div style="TEXT-ALIGN: left; FONT-FAMILY: 'Times New Roman', Times, serif; COLOR: #000000; FONT-SIZE: 10pt">All information required by Part&#160;I of Form&#160;S-8 to be contained in the Section&#160;10(a)&#160;prospectus is omitted from this Registration Statement in accordance with Rule&#160;428 under the Securities Act of 1933, as amended (the &#8220;Securities Act&#8221;) and the Note to Part&#160;I of&#160; Form S-8.</div>
  
  <div>&#160;</div>
  
  <div style="TEXT-ALIGN: center; FONT-FAMILY: 'Times New Roman', Times, serif; COLOR: #000000; FONT-SIZE: 10pt; FONT-WEIGHT: bold">PART II</div>
  
  <div>&#160;</div>
  
  <div style="TEXT-ALIGN: center; FONT-FAMILY: 'Times New Roman', Times, serif; COLOR: #000000; FONT-SIZE: 10pt; FONT-WEIGHT: bold">INFORMATION REQUIRED IN THE REGISTRATION STATEMENT</div>
  
  <div>&#160;</div>
  
  <div style="TEXT-ALIGN: left; FONT-FAMILY: 'Times New Roman', Times, serif; COLOR: #000000; FONT-SIZE: 10pt; FONT-WEIGHT: bold">ITEM&#160;3.&#160;&#160;&#160;&#160;INCORPORATION OF DOCUMENTS BY REFERENCE.</div>
  
  <div>&#160;</div>
  
  <div style="TEXT-ALIGN: left; FONT-FAMILY: 'Times New Roman', Times, serif; COLOR: #000000; FONT-SIZE: 10pt">The following documents furnished or filed with the Securities and Exchange Commission (the &#8220;Commission&#8221;) are incorporated by reference herein, to the extent not superseded by documents or reports subsequently filed or furnished:</div>
  
  <div>&#160;</div>
  
  <div style="TEXT-ALIGN: left">
  <table style="WIDTH: 100%; FONT-FAMILY: 'Times New Roman', Times, serif; FONT-SIZE: 10pt" id="z899f6e07c40a4b0d9819a28534602c0d" class="DSPFListTable" cellspacing="0" cellpadding="0">
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  <td style="WIDTH: 18pt"></td>
  <td style="WIDTH: 18pt; FONT-FAMILY: Symbol, serif; COLOR: #000000; FONT-SIZE: 10pt; VERTICAL-ALIGN: top; align: right">&#183;</td>
  <td style="TEXT-ALIGN: left; FONT-VARIANT: normal; FONT-STYLE: normal; WIDTH: auto; FONT-FAMILY: 'Times New Roman', Times, serif; COLOR: #000000; FONT-SIZE: 10pt; VERTICAL-ALIGN: top; FONT-WEIGHT: normal">Our Reports of Foreign Private Issuer on Form 6-K filed with the Commission on January 5, 2016, January 6, 2016, February 25, 2016, February 29, 2016, March 10, 2016, April 11, 2016, April 13, 2016, April 21, 2016, April 26, 2016, May 11, 2016, May 17, 2016, May 18, 2016, July 1, 2016, July 7, 2016, August 10, 2016, September 2, 2016, September 30, 2016 and October 11, 2016; October 28, 2016, November 15, 2016 and&#160;November 22, 2016.</td>
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  <div>&#160;</div>
  
  <div style="TEXT-ALIGN: left">
  <table style="WIDTH: 100%; FONT-FAMILY: 'Times New Roman', Times, serif; FONT-SIZE: 10pt" id="z73e5bc9b0d534d8d956187c4d0762a73" class="DSPFListTable" cellspacing="0" cellpadding="0">
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  <td style="WIDTH: 18pt; FONT-FAMILY: Symbol, serif; COLOR: #000000; FONT-SIZE: 10pt; VERTICAL-ALIGN: top; align: right">&#183;</td>
  <td style="TEXT-ALIGN: left; WIDTH: auto; FONT-FAMILY: 'Times New Roman', Times, serif; COLOR: #000000; FONT-SIZE: 10pt; VERTICAL-ALIGN: top">Our Annual Report on Form 20-F for the fiscal year ended December 31, 2015.</td>
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  <div>&#160;</div>
  
  <div style="TEXT-ALIGN: left">
  <table style="WIDTH: 100%; FONT-FAMILY: 'Times New Roman', Times, serif; FONT-SIZE: 10pt" id="zf3bc348e4378446bb6da075df340bacc" class="DSPFListTable" cellspacing="0" cellpadding="0">
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  <td style="WIDTH: 18pt; FONT-FAMILY: Symbol, serif; COLOR: #000000; FONT-SIZE: 10pt; VERTICAL-ALIGN: top; align: right">&#183;</td>
  <td style="TEXT-ALIGN: left; WIDTH: auto; FONT-FAMILY: 'Times New Roman', Times, serif; COLOR: #000000; FONT-SIZE: 10pt; VERTICAL-ALIGN: top">The description of the Ordinary Shares included or incorporated by reference under Item 1 of the Registrant&#8217;s Registration Statement on Form 8-A filed with the Commission on December 2, 2015, including any amendment or report filed for the purpose of updating such description.</td>
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  <div>&#160;</div>
  
  <div style="TEXT-ALIGN: left; FONT-FAMILY: 'Times New Roman', Times, serif; COLOR: #000000; FONT-SIZE: 10pt">Additionally, all documents subsequently filed with the Commission by us pursuant to Sections 13(a), 13(c), 14 and 15(d) of the Securities Exchange Act of 1934, as amended (the &#8220;Exchange Act&#8221;), prior to the filing of a post-effective amendment that indicates that all securities offered hereunder have been sold or that deregisters all securities remaining unsold, shall be deemed to be incorporated by reference herein and be a part hereof from the date of the filing of such documents.</div>
  
  <div>&#160;</div>
  
  <div style="TEXT-ALIGN: left; FONT-FAMILY: 'Times New Roman', Times, serif; COLOR: #000000; FONT-SIZE: 10pt">Any statement contained herein or in a document, all or apportion of which is incorporated or deemed to be incorporated by reference herein, will be deemed to be modified or superseded for purposes of this Registration Statement to the extent that a statement contained herein or in any subsequently filed document that also is or is deemed to be incorporated by reference herein modifies or supersedes such statement. Any such statement so modified or superseded will not be deemed, except as so modified or amended, to constitute a part of this Registration Statement.</div>
  
  <div>&#160;</div>
  
  <div style="TEXT-ALIGN: left; FONT-FAMILY: 'Times New Roman', Times, serif; COLOR: #000000; FONT-SIZE: 10pt; FONT-WEIGHT: bold">ITEM&#160;4.&#160;&#160;&#160;&#160;DESCRIPTION OF SECURITIES.</div>
  
  <div>&#160;</div>
  
  <div style="TEXT-ALIGN: left; FONT-FAMILY: 'Times New Roman', Times, serif; COLOR: #000000; FONT-SIZE: 10pt">Not applicable.</div>
  
  <div>&#160;</div>
  
  <div style="TEXT-ALIGN: left; FONT-FAMILY: 'Times New Roman', Times, serif; COLOR: #000000; FONT-SIZE: 10pt; FONT-WEIGHT: bold">ITEM&#160;5.&#160;&#160;&#160;&#160;INTERESTS OF NAMED EXPERTS AND COUNSEL.</div>
  
  <div>&#160;</div>
  
  <div style="TEXT-ALIGN: left; FONT-FAMILY: 'Times New Roman', Times, serif; COLOR: #000000; FONT-SIZE: 10pt">Not applicable.</div>
  
  <div>&#160;</div>
  
  <div style="TEXT-ALIGN: left; FONT-FAMILY: 'Times New Roman', Times, serif; COLOR: #000000; FONT-SIZE: 10pt; FONT-WEIGHT: bold">ITEM&#160;6.&#160;&#160;&#160;&#160;INDEMNIFICATION OF DIRECTORS AND OFFICERS.</div>
  
  <div>&#160;</div>
  
  <div style="TEXT-ALIGN: left; FONT-FAMILY: 'Times New Roman', Times, serif; COLOR: #000000; FONT-SIZE: 10pt">The Registrant&#8217;s articles of association provide that, subject to the Companies Act 2006 of the United Kingdom, every person who is or was at any time a director, alternate director, or former director of the Registrant or of any of its subsidiaries may be indemnified out of the assets of the Registrant against all costs, charges, expenses, losses, damages and liabilities incurred by him or her in performing his duties or the exercise of his or her powers or otherwise in relation to such group company. Generally, under the Companies Act 2006 of the United Kingdom, a company may not indemnify its directors against personal liability covering: liability to the company in cases where the company sues the director (i.e., only liability to third parties can be the subject of an indemnity); liability for fines for criminal conduct or fines imposed by a regulator; or other liabilities, such as legal costs, in criminal cases where the director is convicted, or in civil cases brought by the company where the final judgment goes against the director.</div>
  
  <div>&#160;</div>
  
  <div style="TEXT-ALIGN: left; FONT-FAMILY: 'Times New Roman', Times, serif; COLOR: #000000; FONT-SIZE: 10pt">The Registrant has entered into a deed of indemnity with each of its directors and officers. Except as prohibited by applicable law, these deeds of indemnity may require the Registrant, among other things, to indemnify its directors and officers for certain expenses, including attorneys&#8217; fees, judgments, fines and settlement amounts incurred by such directors and officers in any action or proceeding arising out of their service as a director or officer of Midatech, or one of its subsidiaries, or arising out of the services provided to another company or enterprise at the Registrant&#8217;s request.</div>
  
  <div>&#160;</div>
  
  <div style="MARGIN-TOP: 10pt; MARGIN-BOTTOM: 10pt; CLEAR: both" id="DSPFPageBreakArea">
  <div style="TEXT-ALIGN: center" id="DSPFPageNumberArea"><font style="FONT-STYLE: normal; FONT-FAMILY: 'Times New Roman'; FONT-SIZE: 10pt; FONT-WEIGHT: normal" id="DSPFPageNumber">3</font></div>
  
  <div style="PAGE-BREAK-AFTER: always" id="DSPFPageBreak">
  <hr style="BORDER-RIGHT-WIDTH: 0px; BACKGROUND-COLOR: #000000; MARGIN: 4px 0px; WIDTH: 100%; BORDER-TOP-WIDTH: 0px; BORDER-BOTTOM-WIDTH: 0px; HEIGHT: 2px; COLOR: #000000; CLEAR: both; BORDER-LEFT-WIDTH: 0px" noshade="noshade">
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  <div>&#160;</div>
  
  <div style="TEXT-ALIGN: left; FONT-FAMILY: 'Times New Roman', Times, serif; COLOR: #000000; FONT-SIZE: 10pt">Insofar as indemnification for liabilities arising under the Securities Act of 1933, as amended, may be permitted to directors, officers or persons controlling us pursuant to the foregoing provisions, we have been informed that in the opinion of the Commission, such indemnification is against public policy as expressed in the Securities Act and is, therefore, unenforceable.</div>
  
  <div>&#160;</div>
  
  <div style="TEXT-ALIGN: left; FONT-FAMILY: 'Times New Roman', Times, serif; COLOR: #000000; FONT-SIZE: 10pt; FONT-WEIGHT: bold">ITEM&#160;7.&#160;&#160;&#160;&#160;EXEMPTION FROM REGISTRATION CLAIMED.</div>
  
  <div>&#160;</div>
  
  <div style="TEXT-ALIGN: left; FONT-FAMILY: 'Times New Roman', Times, serif; COLOR: #000000; FONT-SIZE: 10pt">Not applicable.</div>
  
  <div>&#160;</div>
  
  <div style="TEXT-ALIGN: left; FONT-FAMILY: 'Times New Roman', Times, serif; COLOR: #000000; FONT-SIZE: 10pt; FONT-WEIGHT: bold">ITEM&#160;8.&#160;&#160;&#160;&#160;EXHIBITS.</div>
  
  <div>&#160;</div>
  
  <div style="TEXT-ALIGN: left; FONT-FAMILY: 'Times New Roman', Times, serif; COLOR: #000000; FONT-SIZE: 10pt">The list of exhibits is set forth under &#8220;Exhibit Index&#8221; at the end of this registration statement and is incorporated herein by reference.</div>
  
  <div>&#160;</div>
  
  <div style="TEXT-ALIGN: left; FONT-FAMILY: 'Times New Roman', Times, serif; COLOR: #000000; FONT-SIZE: 10pt; FONT-WEIGHT: bold">ITEM&#160;9.&#160;&#160;&#160;&#160;UNDERTAKINGS.</div>
  
  <div>&#160;</div>
  
  <div style="TEXT-ALIGN: left">
  <table style="WIDTH: 100%; FONT-FAMILY: 'Times New Roman', Times, serif; FONT-SIZE: 10pt" id="z8c3649a2f1c9489c8911dc089089b0cd" class="DSPFListTable" cellspacing="0" cellpadding="0">
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  <td style="WIDTH: 18pt; FONT-FAMILY: 'Times New Roman', Times, serif; FONT-SIZE: 10pt; VERTICAL-ALIGN: top; align: right">a.</td>
  <td style="TEXT-ALIGN: left; WIDTH: auto; FONT-FAMILY: 'Times New Roman', Times, serif; COLOR: #000000; FONT-SIZE: 10pt; VERTICAL-ALIGN: top">The undersigned Registrant hereby undertakes:</td>
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  <div>&#160;</div>
  
  <div style="TEXT-ALIGN: left">
  <table style="WIDTH: 100%; FONT-FAMILY: 'Times New Roman', Times, serif; FONT-SIZE: 10pt" id="z60205fe6b8aa47c3b5feacce68e39aab" class="DSPFListTable" cellspacing="0" cellpadding="0">
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  <td style="WIDTH: 18pt; FONT-FAMILY: 'Times New Roman', Times, serif; FONT-SIZE: 10pt; VERTICAL-ALIGN: top; align: right">1.</td>
  <td style="TEXT-ALIGN: left; WIDTH: auto; FONT-FAMILY: 'Times New Roman', Times, serif; COLOR: #000000; FONT-SIZE: 10pt; VERTICAL-ALIGN: top">To file, during any period in which offers or sales are being made, a post-effective amendment to this registration statement:</td>
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  <div>&#160;</div>
  
  <div style="TEXT-ALIGN: left">
  <table style="WIDTH: 100%; FONT-FAMILY: 'Times New Roman', Times, serif; FONT-SIZE: 10pt" id="z5a155fbc063d496188bac57304bc78fe" class="DSPFListTable" cellspacing="0" cellpadding="0">
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  <td style="WIDTH: 99pt"></td>
  <td style="WIDTH: 15pt; FONT-FAMILY: 'Times New Roman', Times, serif; FONT-SIZE: 10pt; VERTICAL-ALIGN: top; align: right">i.</td>
  <td style="TEXT-ALIGN: left; WIDTH: auto; FONT-FAMILY: 'Times New Roman', Times, serif; COLOR: #000000; FONT-SIZE: 10pt; VERTICAL-ALIGN: top">To include any prospectus required by Section&#160;10(a)(3) of the Securities Act of 1933;</td>
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  <div>&#160;</div>
  
  <div style="TEXT-ALIGN: left">
  <table style="WIDTH: 100%; FONT-FAMILY: 'Times New Roman', Times, serif; FONT-SIZE: 10pt" id="zd87ccd1a53844401aed3b8821bbb0447" class="DSPFListTable" cellspacing="0" cellpadding="0">
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  <td style="WIDTH: 99pt"></td>
  <td style="WIDTH: 15pt; FONT-FAMILY: 'Times New Roman', Times, serif; FONT-SIZE: 10pt; VERTICAL-ALIGN: top; align: right">ii.</td>
  <td style="TEXT-ALIGN: left; WIDTH: auto; FONT-FAMILY: 'Times New Roman', Times, serif; COLOR: #000000; FONT-SIZE: 10pt; VERTICAL-ALIGN: top">To reflect in the prospectus any facts or events arising after the effective date of the registration statement (or the most recent post-effective amendment thereof) which, individually or in the aggregate, represent a fundamental change in the information set forth in the registration statement. Notwithstanding the foregoing, any increase or decrease in volume of securities offered (if the total dollar value of securities offered would not exceed that which was registered) and any deviation from the low or high end of the estimated maximum offering range may be reflected in the form of prospectus filed with the Commission pursuant to Rule 424(b) if, in the aggregate, the changes in volume and price represent no more than 20 percent change in the maximum aggregate offering price set forth in the &#8220;Calculation of Registration Fee&#8221; table in the effective registration statement;</td>
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  <div>&#160;</div>
  
  <div style="TEXT-ALIGN: left">
  <table style="WIDTH: 100%; FONT-FAMILY: 'Times New Roman', Times, serif; FONT-SIZE: 10pt" id="z830cb14d68f54a9cba452b57f1eea341" class="DSPFListTable" cellspacing="0" cellpadding="0">
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  <td style="WIDTH: 99pt"></td>
  <td style="WIDTH: 15pt; FONT-FAMILY: 'Times New Roman', Times, serif; FONT-SIZE: 10pt; VERTICAL-ALIGN: top; align: right">iii.</td>
  <td style="TEXT-ALIGN: left; WIDTH: auto; FONT-FAMILY: 'Times New Roman', Times, serif; COLOR: #000000; FONT-SIZE: 10pt; VERTICAL-ALIGN: top">To include any material information with respect to the plan of distribution not previously disclosed in the registration statement or any material change to such information in the registration statement;</td>
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  <div>&#160;</div>
  
  <div style="TEXT-ALIGN: left; FONT-FAMILY: 'Times New Roman', Times, serif; COLOR: #000000; MARGIN-LEFT: 72pt; FONT-SIZE: 10pt"><font style="FONT-FAMILY: 'Times New Roman', Times, serif; FONT-SIZE: 10pt"><u>provided, however</u></font>, that paragraphs (a)(1)(i) and (a)(1)(ii) do not apply if the information required to be included in a post-effective amendment by those paragraphs is contained in reports filed with or furnished to the Commission by the registrant pursuant to Section&#160;13 or Section&#160;15(d) of the Securities Exchange Act of 1934 that are incorporated by reference in the registration statement.</div>
  
  <div>&#160;</div>
  
  <div style="TEXT-ALIGN: left">
  <table style="WIDTH: 100%; FONT-FAMILY: 'Times New Roman', Times, serif; FONT-SIZE: 10pt" id="z19bcd2ab6e3d4246a4201e2bafbb4bfe" class="DSPFListTable" cellspacing="0" cellpadding="0">
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  <td style="WIDTH: 18pt; FONT-FAMILY: 'Times New Roman', Times, serif; FONT-SIZE: 10pt; VERTICAL-ALIGN: top; align: right">2.</td>
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  <div>&#160;</div>
  
  <div style="TEXT-ALIGN: left">
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  <td style="WIDTH: 18pt; FONT-FAMILY: 'Times New Roman', Times, serif; FONT-SIZE: 10pt; VERTICAL-ALIGN: top; align: right">b.</td>
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  <div>&#160;</div>
  
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  <td style="TEXT-ALIGN: left; WIDTH: auto; FONT-FAMILY: 'Times New Roman', Times, serif; COLOR: #000000; FONT-SIZE: 10pt; VERTICAL-ALIGN: top">Insofar as indemnification for liabilities arising under the Securities Act of 1933 may be permitted to directors, officers and controlling persons of the registrant pursuant to the foregoing provisions, or otherwise, the registrant has been advised that in the opinion of the Securities and Exchange Commission such indemnification is against public policy as expressed in the Securities Act of 1933 and is, therefore, unenforceable. In the event that a claim for indemnification against such liabilities (other than the payment by the registrant of expenses incurred or paid by a director, officer or controlling person of the registrant in the successful defense of any action, suit or proceeding) is asserted by such director, officer or controlling person in connection with the securities being registered, the registrant will, unless in the opinion of its counsel the matter has been settled by controlling precedent, submit to a court of appropriate jurisdiction the question whether such indemnification by it is against public policy as expressed in the Securities Act of 1933 as will be governed by the final adjudication of such issue.</td>
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  <div>&#160;</div>
  
  <div style="TEXT-ALIGN: center; FONT-FAMILY: 'Times New Roman', Times, serif; COLOR: #000000; FONT-SIZE: 10pt; FONT-WEIGHT: bold">SIGNATURES</div>
  
  <div>&#160;</div>
  
  <div style="TEXT-ALIGN: left; FONT-VARIANT: normal; FONT-STYLE: normal; FONT-FAMILY: 'Times New Roman', Times, serif; COLOR: #000000; FONT-SIZE: 10pt; FONT-WEIGHT: normal">Pursuant to the requirements of the Securities Act of 1933, as amended, the Registrant certifies that it has reasonable grounds to believe that it meets all of the requirements for filing on Form S-8 and has duly caused this Registration Statement to be signed on its behalf by the undersigned, thereunto duly authorized, in Abingdon, Oxfordshire, United Kingdom, on this 8<sup style="vertical-align: text-top; line-height: 1; font-size: smaller;LINE-HEIGHT: 1; FONT-SIZE: smaller; VERTICAL-ALIGN: text-top">th</sup> day of December, 2016.</div>
  
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  <div style="TEXT-ALIGN: left; FONT-FAMILY: 'Times New Roman', Times, serif; COLOR: #000000; FONT-SIZE: 10pt; FONT-WEIGHT: bold">MIDATECH PHARMA PLC</div>
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  <div style="TEXT-ALIGN: left; TEXT-INDENT: 0pt; MARGIN-LEFT: 0pt; MARGIN-RIGHT: 0pt">By: </div>
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  <div style="TEXT-ALIGN: left; FONT-VARIANT: normal; FONT-STYLE: normal; FONT-FAMILY: 'Times New Roman', Times, serif; COLOR: #000000; FONT-SIZE: 10pt; FONT-WEIGHT: normal">/s/ James N. Phillips</div>
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  <div style="TEXT-ALIGN: left; FONT-FAMILY: 'Times New Roman', Times, serif; COLOR: #000000; FONT-SIZE: 10pt">Name: James N. Phillips</div>
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  <div style="TEXT-ALIGN: left; FONT-FAMILY: 'Times New Roman', Times, serif; COLOR: #000000; FONT-SIZE: 10pt">Title: Chief Executive Officer</div>
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  <div>&#160;</div>
  
  <div style="MARGIN-TOP: 10pt; MARGIN-BOTTOM: 10pt; CLEAR: both" id="DSPFPageBreakArea">
  <div style="TEXT-ALIGN: center" id="DSPFPageNumberArea"><font style="FONT-STYLE: normal; FONT-FAMILY: 'Times New Roman'; FONT-SIZE: 10pt; FONT-WEIGHT: normal" id="DSPFPageNumber">5</font></div>
  
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  <div style="TEXT-ALIGN: center; FONT-FAMILY: 'Times New Roman', Times, serif; COLOR: #000000; FONT-SIZE: 10pt; FONT-WEIGHT: bold">POWER OF ATTORNEY</div>
  
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  <div>&#160;</div>
  
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  <table style="WIDTH: 100%; BORDER-COLLAPSE: collapse; FONT-FAMILY: 'Times New Roman', Times, serif; FONT-SIZE: 10pt" id="z3eff73b06e2a4fba89a55e9c76842003" border="0" cellspacing="0" cellpadding="0" align="center">
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  <div style="TEXT-ALIGN: center; FONT-FAMILY: 'Times New Roman', Times, serif; COLOR: #000000; FONT-SIZE: 10pt; FONT-WEIGHT: bold">Signature</div>
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  <div style="TEXT-ALIGN: center; FONT-FAMILY: 'Times New Roman', Times, serif; COLOR: #000000; FONT-SIZE: 10pt; FONT-WEIGHT: bold">Title</div>
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  <div style="TEXT-ALIGN: center; FONT-FAMILY: 'Times New Roman', Times, serif; COLOR: #000000; MARGIN-LEFT: 8.5pt; FONT-SIZE: 10pt">/s/ James N. Phillips</div>
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  <div style="TEXT-ALIGN: center; FONT-FAMILY: 'Times New Roman', Times, serif; COLOR: #000000; MARGIN-LEFT: 8.5pt; FONT-SIZE: 10pt; FONT-WEIGHT: bold">James N. Phillips</div>
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  <div style="TEXT-ALIGN: center; FONT-FAMILY: 'Times New Roman', Times, serif; COLOR: #000000; FONT-SIZE: 10pt">Chief Executive Officer (Principal Executive Officer) and Director</div>
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  <div style="TEXT-ALIGN: center; FONT-FAMILY: 'Times New Roman', Times, serif; COLOR: #000000; MARGIN-LEFT: 8.5pt; FONT-SIZE: 10pt">/s/ Nicholas Robbins-Cherry</div>
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  <div style="TEXT-ALIGN: center; FONT-FAMILY: 'Times New Roman', Times, serif; COLOR: #000000; MARGIN-LEFT: 8.5pt; FONT-SIZE: 10pt; FONT-WEIGHT: bold">Nicholas Robbins-Cherry</div>
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  <div style="TEXT-ALIGN: center; FONT-FAMILY: 'Times New Roman', Times, serif; COLOR: #000000; FONT-SIZE: 10pt">Chief Financial Officer (Principal Financial Officer</div>
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  <td style="TEXT-ALIGN: center; WIDTH: 49%; VERTICAL-ALIGN: top">and Principal Accounting Officer) and Director</td>
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  <div style="TEXT-ALIGN: center; FONT-FAMILY: 'Times New Roman', Times, serif; COLOR: #000000; MARGIN-LEFT: 8.5pt; FONT-SIZE: 10pt">/s/ Rolf Stahel</div>
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  <div style="TEXT-ALIGN: center; FONT-FAMILY: 'Times New Roman', Times, serif; COLOR: #000000; MARGIN-LEFT: 8.5pt; FONT-SIZE: 10pt; FONT-WEIGHT: bold">Rolf Stahel</div>
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  <div style="TEXT-ALIGN: center; FONT-FAMILY: 'Times New Roman', Times, serif; COLOR: #000000; FONT-SIZE: 10pt">Non-Executive Chairman of the Board</div>
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  <div style="TEXT-ALIGN: center; FONT-FAMILY: 'Times New Roman', Times, serif; COLOR: #000000; MARGIN-LEFT: 8.5pt; FONT-SIZE: 10pt">/s/ John Johnston</div>
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  <div style="TEXT-ALIGN: center; FONT-FAMILY: 'Times New Roman', Times, serif; COLOR: #000000; MARGIN-LEFT: 8.5pt; FONT-SIZE: 10pt; FONT-WEIGHT: bold">John Johnston</div>
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  <div style="TEXT-ALIGN: center; FONT-FAMILY: 'Times New Roman', Times, serif; COLOR: #000000; FONT-SIZE: 10pt">Non-Executive Director</div>
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  <div style="TEXT-ALIGN: center; FONT-FAMILY: 'Times New Roman', Times, serif; COLOR: #000000; MARGIN-LEFT: 8.5pt; FONT-SIZE: 10pt">/s/ Michele Luzi</div>
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  <div style="TEXT-ALIGN: center; FONT-FAMILY: 'Times New Roman', Times, serif; COLOR: #000000; MARGIN-LEFT: 8.5pt; FONT-SIZE: 10pt; FONT-WEIGHT: bold">Michele Luzi</div>
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  <div style="TEXT-ALIGN: center; FONT-FAMILY: 'Times New Roman', Times, serif; COLOR: #000000; FONT-SIZE: 10pt">Non-Executive Director</div>
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  <div style="TEXT-ALIGN: center; FONT-FAMILY: 'Times New Roman', Times, serif; COLOR: #000000; MARGIN-LEFT: 8.5pt; FONT-SIZE: 10pt">/s/ Pavlo Protopapa</div>
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  <div style="TEXT-ALIGN: center; FONT-FAMILY: 'Times New Roman', Times, serif; COLOR: #000000; MARGIN-LEFT: 8.5pt; FONT-SIZE: 10pt; FONT-WEIGHT: bold">Pavlo Protopapa</div>
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  <div style="TEXT-ALIGN: center; FONT-FAMILY: 'Times New Roman', Times, serif; COLOR: #000000; FONT-SIZE: 10pt">Non-Executive Director</div>
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  <div style="TEXT-ALIGN: center; FONT-FAMILY: 'Times New Roman', Times, serif; COLOR: #000000; MARGIN-LEFT: 8.5pt; FONT-SIZE: 10pt">/s/ Simon Turton</div>
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  <div style="TEXT-ALIGN: center; FONT-FAMILY: 'Times New Roman', Times, serif; COLOR: #000000; MARGIN-LEFT: 8.5pt; FONT-SIZE: 10pt; FONT-WEIGHT: bold">Simon Turton, Ph.D.</div>
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  <div style="TEXT-ALIGN: center; FONT-FAMILY: 'Times New Roman', Times, serif; COLOR: #000000; FONT-SIZE: 10pt">Senior Independent Non-Executive Director</div>
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  <div style="TEXT-ALIGN: center; FONT-FAMILY: 'Times New Roman', Times, serif; COLOR: #000000; MARGIN-LEFT: 8.5pt; FONT-SIZE: 10pt">/s/ Sijmen de Vries</div>
  </td>
  <td style="PADDING-BOTTOM: 2px; WIDTH: 2%; VERTICAL-ALIGN: bottom">&#160;</td>
  <td style="PADDING-BOTTOM: 2px; WIDTH: 49%; VERTICAL-ALIGN: bottom">&#160;</td>
  </tr>
  
  <tr>
  <td style="WIDTH: 49%; VERTICAL-ALIGN: top">
  <div style="TEXT-ALIGN: center; FONT-FAMILY: 'Times New Roman', Times, serif; COLOR: #000000; MARGIN-LEFT: 8.5pt; FONT-SIZE: 10pt; FONT-WEIGHT: bold">Sijmen de Vries, M.D.</div>
  </td>
  <td style="WIDTH: 2%; VERTICAL-ALIGN: bottom">&#160;</td>
  <td style="WIDTH: 49%; VERTICAL-ALIGN: bottom">
  <div style="TEXT-ALIGN: center">Non-Executive Director</div>
  </td>
  </tr>
  </table>
  
  <div>&#160;</div>
  
  <div style="MARGIN-TOP: 10pt; MARGIN-BOTTOM: 10pt; CLEAR: both" id="DSPFPageBreakArea">
  <div style="TEXT-ALIGN: center" id="DSPFPageNumberArea"><font style="FONT-STYLE: normal; FONT-FAMILY: 'Times New Roman'; FONT-SIZE: 10pt; FONT-WEIGHT: normal" id="DSPFPageNumber">6</font></div>
  
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  <div>&#160;</div>
  
  <div style="TEXT-ALIGN: center; FONT-FAMILY: 'Times New Roman', Times, serif; COLOR: #000000; FONT-SIZE: 10pt; FONT-WEIGHT: bold">AUTHORIZED REPRESENTATIVE</div>
  
  <div>&#160;</div>
  
  <div style="TEXT-ALIGN: left; FONT-VARIANT: normal; FONT-STYLE: normal; FONT-FAMILY: 'Times New Roman', Times, serif; COLOR: #000000; FONT-SIZE: 10pt; FONT-WEIGHT: normal">Pursuant to the requirements of the Securities Act of 1933, as amended, the undersigned, the duly authorized representative in the United States of America of Midatech Pharma PLC, has signed this Registration Statement on Form S-8 on this 8<sup style="vertical-align: text-top; line-height: 1; font-size: smaller;LINE-HEIGHT: 1; FONT-SIZE: smaller; VERTICAL-ALIGN: text-top">th</sup> day of December, 2016.</div>
  
  <div>&#160;</div>
  
  <div>
  <table style="WIDTH: 100%; BORDER-COLLAPSE: separate; FONT-FAMILY: 'Times New Roman', Times, serif; FONT-SIZE: 10pt" id="z35a0d25081c240268e96b7642ca6b527" border="0" cellspacing="0" cellpadding="0">
  <tr>
  <td style="WIDTH: 50%" valign="top">&#160;</td>
  <td style="WIDTH: 38%" valign="top" colspan="2">
  <div style="TEXT-ALIGN: left; FONT-FAMILY: 'Times New Roman', Times, serif; COLOR: #000000; FONT-SIZE: 10pt; FONT-WEIGHT: bold"><strong>Midatech Pharma PLC</strong></div>
  </td>
  <td style="WIDTH: 12%" valign="top">&#160;</td>
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  <td style="WIDTH: 50%" valign="top">&#160;</td>
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  <div style="TEXT-ALIGN: left; TEXT-INDENT: 0pt; MARGIN-LEFT: 0pt; MARGIN-RIGHT: 0pt">&#160;</div>
  </td>
  <td style="PADDING-BOTTOM: 2px; WIDTH: 3%" valign="top">
  <div style="TEXT-ALIGN: left; TEXT-INDENT: 0pt; MARGIN-LEFT: 0pt; MARGIN-RIGHT: 0pt">By: </div>
  </td>
  <td style="BORDER-BOTTOM: #000000 2px solid; WIDTH: 35%" valign="top" nowrap="nowrap" align="left">
  <div style="TEXT-ALIGN: left; FONT-VARIANT: normal; FONT-STYLE: normal; FONT-FAMILY: 'Times New Roman', Times, serif; FONT-SIZE: 10pt; FONT-WEIGHT: normal"><font style="COLOR: #000000">/s/ John Petrolino&#160;&#160;&#160;&#160;</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;</div>
  </td>
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  <td style="WIDTH: 3%" valign="top">
  <div style="TEXT-ALIGN: left; FONT-FAMILY: 'Times New Roman', Times, serif; COLOR: #000000; FONT-SIZE: 10pt">Name:&#160;&#160; </div>
  </td>
  <td style="WIDTH: 35%" valign="bottom" nowrap="nowrap" align="left">
  <div style="TEXT-ALIGN: left; FONT-FAMILY: 'Times New Roman', Times, serif; COLOR: #000000; FONT-SIZE: 10pt">John Petrolino</div>
  </td>
  <td style="WIDTH: 12%" valign="top">&#160;</td>
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  <td style="WIDTH: 50%" valign="top">&#160;</td>
  <td style="WIDTH: 3%" valign="top">Title:</td>
  <td style="WIDTH: 35%" valign="bottom" nowrap="nowrap" align="left">
  <div style="TEXT-ALIGN: left; FONT-FAMILY: 'Times New Roman', serif; FONT-SIZE: 10pt">General Counsel and Chief Compliance Officer</div>
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  <div>&#160;</div>
  
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  <div>&#160;</div>
  
  <div style="TEXT-ALIGN: left; FONT-FAMILY: 'Times New Roman', Times, serif; COLOR: #000000; FONT-SIZE: 10pt; FONT-WEIGHT: bold">EXHIBIT INDEX</div>
  
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  <div style="BORDER-BOTTOM: 1pt solid; TEXT-ALIGN: left; FONT-FAMILY: 'Times New Roman', Times, serif; COLOR: #000000; FONT-SIZE: 10pt; FONT-WEIGHT: bold">Exhibit&#160;No.</div>
  </td>
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  <div style="TEXT-ALIGN: left; FONT-FAMILY: 'Times New Roman', Times, serif; COLOR: #000000; FONT-SIZE: 10pt">&#160;&#160;</div>
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  <div style="TEXT-ALIGN: left; FONT-FAMILY: 'Times New Roman', Times, serif; COLOR: #000000; FONT-SIZE: 10pt; FONT-WEIGHT: bold">Description of Exhibit</div>
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  <td style="WIDTH: 6.98%; VERTICAL-ALIGN: top">&#160;</td>
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  <td style="WIDTH: 6.98%; VERTICAL-ALIGN: top">
  <div style="TEXT-ALIGN: left; FONT-FAMILY: 'Times New Roman', Times, serif; COLOR: #000000; FONT-SIZE: 10pt">3.1</div>
  </td>
  <td style="WIDTH: 3%; VERTICAL-ALIGN: bottom">
  <div style="TEXT-ALIGN: left; FONT-FAMILY: 'Times New Roman', Times, serif; COLOR: #000000; FONT-SIZE: 10pt">&#160;&#160;</div>
  </td>
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  <div style="TEXT-ALIGN: left; FONT-FAMILY: 'Times New Roman', Times, serif; COLOR: #000000; FONT-SIZE: 10pt">Articles of Association of Midatech Pharma PLC (filed as Exhibit 3.1 to the Registrant&#8217;s Registration Statement on Form F-4 (File No. 333-206305), filed with the Commission on August&#160;11, 2015, and incorporated herein by reference).</div>
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  <td style="BACKGROUND-COLOR: #ffffff; WIDTH: 6.98%; VERTICAL-ALIGN: top">&#160;</td>
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  <td style="BACKGROUND-COLOR: #ffffff; WIDTH: 90%; VERTICAL-ALIGN: top">&#160;</td>
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  <div style="TEXT-ALIGN: left; FONT-FAMILY: 'Times New Roman', Times, serif; COLOR: #000000; FONT-SIZE: 10pt">4.1</div>
  </td>
  <td style="WIDTH: 3%; VERTICAL-ALIGN: bottom">
  <div style="TEXT-ALIGN: left; FONT-FAMILY: 'Times New Roman', Times, serif; COLOR: #000000; FONT-SIZE: 10pt">&#160;&#160;</div>
  </td>
  <td style="WIDTH: 90%; VERTICAL-ALIGN: top">
  <div style="TEXT-ALIGN: left; FONT-FAMILY: 'Times New Roman', Times, serif; COLOR: #000000; FONT-SIZE: 10pt">Specimen certificate representing ordinary shares of Midatech Pharma PLC (filed as Exhibit 4.1 to the Registrant&#8217;s Registration Statement on Form F-4 (File No. 333-206305), filed with the Commission on August 11, 2015, as amended, and incorporated herein by reference).</div>
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  <td style="BACKGROUND-COLOR: #ffffff; WIDTH: 6.98%; VERTICAL-ALIGN: top">&#160;</td>
  <td style="BACKGROUND-COLOR: #ffffff; WIDTH: 3%; VERTICAL-ALIGN: top">&#160;</td>
  <td style="BACKGROUND-COLOR: #ffffff; WIDTH: 90%; VERTICAL-ALIGN: top">&#160;</td>
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  <td style="WIDTH: 6.98%; VERTICAL-ALIGN: top">
  <div style="TEXT-ALIGN: left; FONT-FAMILY: 'Times New Roman', Times, serif; COLOR: #000000; FONT-SIZE: 10pt">4.2</div>
  </td>
  <td style="WIDTH: 3%; VERTICAL-ALIGN: bottom">
  <div style="TEXT-ALIGN: left; FONT-FAMILY: 'Times New Roman', Times, serif; COLOR: #000000; FONT-SIZE: 10pt">&#160;&#160;</div>
  </td>
  <td style="WIDTH: 90%; VERTICAL-ALIGN: top">
  <div style="TEXT-ALIGN: left; FONT-FAMILY: 'Times New Roman', Times, serif; COLOR: #000000; FONT-SIZE: 10pt">Deposit Agreement dated December 4, 2015, by and among Midatech Pharma PLC, Deutsche Bank Trust Company Americas, as depositary, and all owners and holders from time to time of American Depositary Shares issued thereunder (filed as Exhibit (a) to the Registrant&#8217;s Registration Statement on Form F-6 (File No. 333-207186), filed with the Commission on September 29, 2015, as amended on October 27, 2015, and incorporated herein by reference).</div>
  </td>
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  <td style="BACKGROUND-COLOR: #ffffff; WIDTH: 6.98%; VERTICAL-ALIGN: top">&#160;</td>
  <td style="BACKGROUND-COLOR: #ffffff; WIDTH: 3%; VERTICAL-ALIGN: top">&#160;</td>
  <td style="BACKGROUND-COLOR: #ffffff; WIDTH: 90%; VERTICAL-ALIGN: top">&#160;</td>
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  <td style="WIDTH: 6.98%; VERTICAL-ALIGN: top">
  <div style="TEXT-ALIGN: left; FONT-FAMILY: 'Times New Roman', Times, serif; COLOR: #000000; FONT-SIZE: 10pt">4.3</div>
  </td>
  <td style="WIDTH: 3%; VERTICAL-ALIGN: bottom">
  <div style="TEXT-ALIGN: left; FONT-FAMILY: 'Times New Roman', Times, serif; COLOR: #000000; FONT-SIZE: 10pt">&#160;&#160;</div>
  </td>
  <td style="WIDTH: 90%; VERTICAL-ALIGN: top">
  <div style="TEXT-ALIGN: left; FONT-FAMILY: 'Times New Roman', Times, serif; COLOR: #000000; FONT-SIZE: 10pt">Form of American Depositary Receipt (included in Exhibit 4.2).</div>
  </td>
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  <td style="BACKGROUND-COLOR: #ffffff; WIDTH: 6.98%; VERTICAL-ALIGN: top">&#160;</td>
  <td style="BACKGROUND-COLOR: #ffffff; WIDTH: 3%; VERTICAL-ALIGN: top">&#160;</td>
  <td style="BACKGROUND-COLOR: #ffffff; WIDTH: 90%; VERTICAL-ALIGN: top">&#160;</td>
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  <td style="WIDTH: 6.98%; VERTICAL-ALIGN: top">
  <div style="TEXT-ALIGN: left; FONT-FAMILY: 'Times New Roman', Times, serif; COLOR: #000000; FONT-SIZE: 10pt">5.1*</div>
  </td>
  <td style="WIDTH: 3%; VERTICAL-ALIGN: bottom">
  <div style="TEXT-ALIGN: left; FONT-FAMILY: 'Times New Roman', Times, serif; COLOR: #000000; FONT-SIZE: 10pt">&#160;&#160;</div>
  </td>
  <td style="WIDTH: 90%; VERTICAL-ALIGN: top">
  <div style="TEXT-ALIGN: left; FONT-FAMILY: 'Times New Roman', Times, serif; COLOR: #000000; FONT-SIZE: 10pt">Opinion of Gateley Plc.</div>
  </td>
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  <td style="BACKGROUND-COLOR: #ffffff; WIDTH: 6.98%; VERTICAL-ALIGN: top">&#160;</td>
  <td style="BACKGROUND-COLOR: #ffffff; WIDTH: 3%; VERTICAL-ALIGN: top">&#160;</td>
  <td style="BACKGROUND-COLOR: #ffffff; WIDTH: 90%; VERTICAL-ALIGN: top">&#160;</td>
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  <td style="WIDTH: 6.98%; VERTICAL-ALIGN: top">
  <div style="TEXT-ALIGN: left; FONT-FAMILY: 'Times New Roman', Times, serif; COLOR: #000000; FONT-SIZE: 10pt">23.1*</div>
  </td>
  <td style="WIDTH: 3%; VERTICAL-ALIGN: bottom">
  <div style="TEXT-ALIGN: left; FONT-FAMILY: 'Times New Roman', Times, serif; COLOR: #000000; FONT-SIZE: 10pt">&#160;&#160;</div>
  </td>
  <td style="WIDTH: 90%; VERTICAL-ALIGN: top">
  <div style="TEXT-ALIGN: left; FONT-FAMILY: 'Times New Roman', Times, serif; COLOR: #000000; FONT-SIZE: 10pt">Consent of BDO LLP, independent registered public accounting firm. </div>
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  <td style="BACKGROUND-COLOR: #ffffff; WIDTH: 6.98%; VERTICAL-ALIGN: top">&#160;</td>
  <td style="BACKGROUND-COLOR: #ffffff; WIDTH: 3%; VERTICAL-ALIGN: bottom">&#160;</td>
  <td style="BACKGROUND-COLOR: #ffffff; WIDTH: 90%; VERTICAL-ALIGN: top">&#160;</td>
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  <td style="WIDTH: 6.98%; VERTICAL-ALIGN: top">
  <div>23.4*</div>
  </td>
  <td style="WIDTH: 3%; VERTICAL-ALIGN: bottom">
  <div style="TEXT-ALIGN: left; FONT-FAMILY: 'Times New Roman', Times, serif; COLOR: #000000; FONT-SIZE: 10pt">&#160;</div>
  </td>
  <td style="WIDTH: 90%; VERTICAL-ALIGN: top">
  <div>Consent of Gateley Plc (included in Exhibit 5.1).</div>
  </td>
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  <td style="BACKGROUND-COLOR: #ffffff; WIDTH: 6.98%; VERTICAL-ALIGN: top">&#160;</td>
  <td style="BACKGROUND-COLOR: #ffffff; WIDTH: 3%; VERTICAL-ALIGN: top">&#160;</td>
  <td style="BACKGROUND-COLOR: #ffffff; WIDTH: 90%; VERTICAL-ALIGN: top">&#160;</td>
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  <td style="WIDTH: 6.98%; VERTICAL-ALIGN: top">
  <div style="TEXT-ALIGN: left; FONT-FAMILY: 'Times New Roman', Times, serif; COLOR: #000000; FONT-SIZE: 10pt">24.1*</div>
  </td>
  <td style="WIDTH: 3%; VERTICAL-ALIGN: bottom">
  <div style="TEXT-ALIGN: left; FONT-FAMILY: 'Times New Roman', Times, serif; COLOR: #000000; FONT-SIZE: 10pt">&#160;&#160;</div>
  </td>
  <td style="WIDTH: 90%; VERTICAL-ALIGN: top">
  <div style="TEXT-ALIGN: left; FONT-FAMILY: 'Times New Roman', Times, serif; COLOR: #000000; FONT-SIZE: 10pt">Power of Attorney (included on the signature page).</div>
  </td>
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  <td style="BACKGROUND-COLOR: #ffffff; WIDTH: 6.98%; VERTICAL-ALIGN: top">&#160;</td>
  <td style="BACKGROUND-COLOR: #ffffff; WIDTH: 3%; VERTICAL-ALIGN: bottom">&#160;</td>
  <td style="BACKGROUND-COLOR: #ffffff; WIDTH: 90%; VERTICAL-ALIGN: top">&#160;</td>
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  <td style="WIDTH: 6.98%; VERTICAL-ALIGN: top">
  <div>99.1*</div>
  </td>
  <td style="WIDTH: 3%; VERTICAL-ALIGN: bottom">&#160;</td>
  <td style="WIDTH: 90%; VERTICAL-ALIGN: top">
  <div>Midatech Pharma PLC 2016 U.S. Option Plan</div>
  </td>
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  <tr>
  <td style="BACKGROUND-COLOR: #ffffff; WIDTH: 6.98%; VERTICAL-ALIGN: top">&#160;</td>
  <td style="BACKGROUND-COLOR: #ffffff; WIDTH: 3%; VERTICAL-ALIGN: bottom">&#160;</td>
  <td style="BACKGROUND-COLOR: #ffffff; WIDTH: 90%; VERTICAL-ALIGN: top">&#160;</td>
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  <td style="WIDTH: 6.98%; VERTICAL-ALIGN: top">
  <div>*</div>
  </td>
  <td style="WIDTH: 3%; VERTICAL-ALIGN: bottom">&#160;</td>
  <td style="WIDTH: 90%; VERTICAL-ALIGN: top">
  <div>Filed herewith.</div>
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metadata_filer: {"company-data": {"conformed-name": "Midatech Pharma Plc", "cik": "0001643918", "assigned-sic": "2834", "irs-number": "000000000", "state-of-incorporation": "X0", "fiscal-year-end": "1231"}, "filing-values": {"form-type": "S-8", "act": "33", "file-number": "333-214969", "film-number": "162041117"}, "business-address": {"street1": "65 MILTON PARK", "city": "ABINGDON, OXFORDSHIRE", "state": "X0", "zip": "OX14 4RQ", "phone": "44 (0)1235 841 575"}, "mail-address": {"street1": "65 MILTON PARK", "city": "ABINGDON, OXFORDSHIRE", "state": "X0", "zip": "OX14 4RQ"}}
text: AS FILED WITH THE SECURITIES AND EXCHANGE COMMISSION ON DECEMBER 8, 2016
  Registration No. 333-
  UNITED STATES
  SECURITIES AND EXCHANGE COMMISSION
  Washington, D.C. 20549
  FORM S-8
  REGISTRATION STATEMENT
  UNDER
  THE SECURITIES ACT OF 1933
  Midatech Pharma PLC
  (Exact name of registrant as specified in its charter)
  England and Wales
  Not Applicable
  (State or Other Jurisdiction of
  Incorporation or Organization)
  (IRS Employer
  Identification No.)
  65 Innovation Drive
  Milton Park
  Abingdon, Oxfordshire, OX14 4RQ, United Kingdom
  Tel: +44 (0)1235 841 575
  (Address, including zip code, and telephone number, including area code, of registrant's principal executive offices)
  Midatech Pharma PLC 2016 U.S. Option Plan
  (Full title of the plans)
  Midatech Pharma PLC
  Attn: John C. Petrolino
  8601 Six Forks Road, Suite 160
  Raleigh, North Carolina 25414
  (Name, address, including zip code, and telephone number, including area code, of agent for service)
  Copies of communications to:
  R. Douglas Harmon, Esq.
  Michel Vanesse, Esq.
  Parker Poe Adams & Bernstein LLP
  Three Wells Fargo Center
  401 South Tryon Street, Suite 3000
  Charlotte, NC 28202
  T: (704) 372-9000
  F: (704) 334-4706
  Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, or a smaller reporting company. See the definitions of "large accelerated filer," "accelerated filer" and "smaller reporting company" in Rule 12b-2 of the Exchange Act (Check one):
  Large accelerated filer
  ☐
  Accelerated filer
  ☐
  Non-accelerated filer
  ☑ (Do not check if a smaller reporting company)
  Smaller reporting company
  ☐
  CALCULATION OF REGISTRATION FEE
  Title of securities to be registered
  Amount
  to be
  registered (1)(2)(3)
  Proposed
  maximum
  offering price
  per share (4)
  Proposed
  maximum
  aggregate
  offering price
  Amount of
  registration fee
  Ordinary shares, nominal value 0.005p per share, to be
  issued under the Midatech Pharma PLC 2016 U.S.
  Option Plan
  1,000,000
  $1.54
  $1,540,000
  $178.49
  (1)
  Represents the maximum number of ordinary shares, nominal value 0.005p per share (the "Ordinary Shares"), of Midatech Pharma PLC (the "Company") issuable under outstanding option awards granted under the Midatech Pharma PLC 2016 U.S. Option Plan (the "Plan").
  (2)
  The Ordinary Shares of Midatech may be represented by Midatech's American Depositary Shares ("ADS"), evidenced by American Depositary Receipts, each representing two Ordinary Shares. A separate Registration Statement on Form F-6  (File No. 333-207186) was filed with the Securities and Exchange Commission on September 29, 2015, as amended on October 27, 2015, for the registration of ADSs evidenced by American Depositary Receipts issuable upon deposit of Ordinary Shares.
  (3)
  Pursuant to Rule 416(a) under the Securities Act of 1933, as amended (the "Securities Act"), the number of Ordinary Shares registered includes an indeterminable number of Ordinary Shares as required to prevent dilution resulting from a stock split, stock dividend or similar transaction that results in an increase in the number of outstanding Ordinary Shares.
  (4)
  Estimated solely for the purposes of calculating the registration fee. Such estimate has been computed in accordance with Rule 457(c) and 457(h) under the Securities Act, based on the average of the high and low quotation for Ordinary Shares on the AIM Market of the London Stock Exchange plc on December 2, 2016, and the buying rate for British pounds sterling of £1.00=$1.2685 based on noon buying rates published by the Federal Reserve Bank of New York for British pounds sterling on December 2, 2016.
  2
  PART I
  INFORMATION REQUIRED IN THE SECTION 10(a) PROSPECTUS
  All information required by Part I of Form S-8 to be contained in the Section 10(a) prospectus is omitted from this Registration Statement in accordance with Rule 428 under the Securities Act of 1933, as amended (the "Securities Act") and the Note to Part I of  Form S-8.
  PART II
  INFORMATION REQUIRED IN THE REGISTRATION STATEMENT
  ITEM 3.    INCORPORATION OF DOCUMENTS BY REFERENCE.
  The following documents furnished or filed with the Securities and Exchange Commission (the "Commission") are incorporated by reference herein, to the extent not superseded by documents or reports subsequently filed or furnished:
  ·
  Our Reports of Foreign Private Issuer on Form 6-K filed with the Commission on January 5, 2016, January 6, 2016, February 25, 2016, February 29, 2016, March 10, 2016, April 11, 2016, April 13, 2016, April 21, 2016, April 26, 2016, May 11, 2016, May 17, 2016, May 18, 2016, July 1, 2016, July 7, 2016, August 10, 2016, September 2, 2016, September 30, 2016 and October 11, 2016; October 28, 2016, November 15, 2016 and November 22, 2016.
  ·
  Our Annual Report on Form 20-F for the fiscal year ended December 31, 2015.
  ·
  The description of the Ordinary Shares included or incorporated by reference under Item 1 of the Registrant's Registration Statement on Form 8-A filed with the Commission on December 2, 2015, including any amendment or report filed for the purpose of updating such description.
  Additionally, all documents subsequently filed with the Commission by us pursuant to Sections 13(a), 13(c), 14 and 15(d) of the Securities Exchange Act of 1934, as amended (the "Exchange Act"), prior to the filing of a post-effective amendment that indicates that all securities offered hereunder have been sold or that deregisters all securities remaining unsold, shall be deemed to be incorporated by reference herein and be a part hereof from the date of the filing of such documents.
  Any statement contained herein or in a document, all or apportion of which is incorporated or deemed to be incorporated by reference herein, will be deemed to be modified or superseded for purposes of this Registration Statement to the extent that a statement contained herein or in any subsequently filed document that also is or is deemed to be incorporated by reference herein modifies or supersedes such statement. Any such statement so modified or superseded will not be deemed, except as so modified or amended, to constitute a part of this Registration Statement.
  ITEM 4.    DESCRIPTION OF SECURITIES.
  Not applicable.
  ITEM 5.    INTERESTS OF NAMED EXPERTS AND COUNSEL.
  Not applicable.
  ITEM 6.    INDEMNIFICATION OF DIRECTORS AND OFFICERS.
  The Registrant's articles of association provide that, subject to the Companies Act 2006 of the United Kingdom, every person who is or was at any time a director, alternate director, or former director of the Registrant or of any of its subsidiaries may be indemnified out of the assets of the Registrant against all costs, charges, expenses, losses, damages and liabilities incurred by him or her in performing his duties or the exercise of his or her powers or otherwise in relation to such group company. Generally, under the Companies Act 2006 of the United Kingdom, a company may not indemnify its directors against personal liability covering: liability to the company in cases where the company sues the director (i.e., only liability to third parties can be the subject of an indemnity); liability for fines for criminal conduct or fines imposed by a regulator; or other liabilities, such as legal costs, in criminal cases where the director is convicted, or in civil cases brought by the company where the final judgment goes against the director.
  The Registrant has entered into a deed of indemnity with each of its directors and officers. Except as prohibited by applicable law, these deeds of indemnity may require the Registrant, among other things, to indemnify its directors and officers for certain expenses, including attorneys' fees, judgments, fines and settlement amounts incurred by such directors and officers in any action or proceeding arising out of their service as a director or officer of Midatech, or one of its subsidiaries, or arising out of the services provided to another company or enterprise at the Registrant's request.
  3
  Insofar as indemnification for liabilities arising under the Securities Act of 1933, as amended, may be permitted to directors, officers or persons controlling us pursuant to the foregoing provisions, we have been informed that in the opinion of the Commission, such indemnification is against public policy as expressed in the Securities Act and is, therefore, unenforceable.
  ITEM 7.    EXEMPTION FROM REGISTRATION CLAIMED.
  Not applicable.
  ITEM 8.    EXHIBITS.
  The list of exhibits is set forth under "Exhibit Index" at the end of this registration statement and is incorporated herein by reference.
  ITEM 9.    UNDERTAKINGS.
  a.
  The undersigned Registrant hereby undertakes:
  1.
  To file, during any period in which offers or sales are being made, a post-effective amendment to this registration statement:
  i.
  To include any prospectus required by Section 10(a)(3) of the Securities Act of 1933;
  ii.
  To reflect in the prospectus any facts or events arising after the effective date of the registration statement (or the most recent post-effective amendment thereof) which, individually or in the aggregate, represent a fundamental change in the information set forth in the registration statement. Notwithstanding the foregoing, any increase or decrease in volume of securities offered (if the total dollar value of securities offered would not exceed that which was registered) and any deviation from the low or high end of the estimated maximum offering range may be reflected in the form of prospectus filed with the Commission pursuant to Rule 424(b) if, in the aggregate, the changes in volume and price represent no more than 20 percent change in the maximum aggregate offering price set forth in the "Calculation of Registration Fee" table in the effective registration statement;
  iii.
  To include any material information with respect to the plan of distribution not previously disclosed in the registration statement or any material change to such information in the registration statement;
  provided, however
  , that paragraphs (a)(1)(i) and (a)(1)(ii) do not apply if the information required to be included in a post-effective amendment by those paragraphs is contained in reports filed with or furnished to the Commission by the registrant pursuant to Section 13 or Section 15(d) of the Securities Exchange Act of 1934 that are incorporated by reference in the registration statement.
  2.
  That, for the purpose of determining any liability under the Securities Act of 1933, each such post-effective amendment shall be deemed to be a new registration statement relating to the securities offered therein, and the offering of such securities at that time shall be deemed to be the initial
  bona fide
  offering thereof; and
  3.
  To remove from registration by means of a post-effective amendment any of the securities being registered which remain unsold at the termination of the offering.
  b.
  The undersigned registrant hereby undertakes that, for purposes of determining any liability under the Securities Act of 1933, each filing of the registrant's annual report pursuant to Section 13(a) or 15(d) of the Securities Exchange Act of 1934 (and, where applicable, each filing of an employee benefit plan's annual report pursuant to Section 15(d) of the Securities Exchange Act of 1934) that is incorporated by reference in the registration statement shall be deemed to be a new registration statement relating to the securities offered therein, and the offering of such securities at that time shall be deemed to be the initial
  bona fide
  offering thereof.
  c.
  Insofar as indemnification for liabilities arising under the Securities Act of 1933 may be permitted to directors, officers and controlling persons of the registrant pursuant to the foregoing provisions, or otherwise, the registrant has been advised that in the opinion of the Securities and Exchange Commission such indemnification is against public policy as expressed in the Securities Act of 1933 and is, therefore, unenforceable. In the event that a claim for indemnification against such liabilities (other than the payment by the registrant of expenses incurred or paid by a director, officer or controlling person of the registrant in the successful defense of any action, suit or proceeding) is asserted by such director, officer or controlling person in connection with the securities being registered, the registrant will, unless in the opinion of its counsel the matter has been settled by controlling precedent, submit to a court of appropriate jurisdiction the question whether such indemnification by it is against public policy as expressed in the Securities Act of 1933 as will be governed by the final adjudication of such issue.
  4
  SIGNATURES
  Pursuant to the requirements of the Securities Act of 1933, as amended, the Registrant certifies that it has reasonable grounds to believe that it meets all of the requirements for filing on Form S-8 and has duly caused this Registration Statement to be signed on its behalf by the undersigned, thereunto duly authorized, in Abingdon, Oxfordshire, United Kingdom, on this 8
  th
  day of December, 2016.
  MIDATECH PHARMA PLC
  By:
  /s/ James N. Phillips
  Name: James N. Phillips
  Title: Chief Executive Officer
  5
  POWER OF ATTORNEY
  We, the undersigned, hereby severally constitute and appoint each of James N. Phillips, Nicholas Robbins-Cherry and John Petrolino, each in their individual capacity, our true and lawful attorney-in-fact and agent, with full power of substitution and resubstitution, for him and his name, place and stead, in any and all capacities, to execute any and all amendments (including post-effective amendments) to this registration statement, to sign any registration statement filed pursuant to Rule 462(b) of the Securities Act of 1933, as amended, and to cause the same to be filed with all exhibits thereto, and all documents in connection therewith, with the Securities and Exchange Commission, granting unto said attorney-in-fact and agent, full power and authority to do and perform each and every act and thing requisite and desirable to be done in and about the premises as fully and to all intents and purposes as we might or could do in person, hereby ratifying and confirming all facts and things that said attorney-in-fact and agent, or his substitute may lawfully do or cause to be done by virtue thereof.
  Pursuant to the requirements of the Securities Act of 1933, as amended, this Registration Statement on Form S-8 has been signed by the following persons in the capacities as indicated on December 8, 2016.
  Signature
  Title
  /s/ James N. Phillips
  James N. Phillips
  Chief Executive Officer (Principal Executive Officer) and Director
  /s/ Nicholas Robbins-Cherry
  Nicholas Robbins-Cherry
  Chief Financial Officer (Principal Financial Officer
  and Principal Accounting Officer) and Director
  /s/ Rolf Stahel
  Rolf Stahel
  Non-Executive Chairman of the Board
  /s/ John Johnston
  John Johnston
  Non-Executive Director
  /s/ Michele Luzi
  Michele Luzi
  Non-Executive Director
  /s/ Pavlo Protopapa
  Pavlo Protopapa
  Non-Executive Director
  /s/ Simon Turton
  Simon Turton, Ph.D.
  Senior Independent Non-Executive Director
  /s/ Sijmen de Vries
  Sijmen de Vries, M.D.
  Non-Executive Director
  6
  AUTHORIZED REPRESENTATIVE
  Pursuant to the requirements of the Securities Act of 1933, as amended, the undersigned, the duly authorized representative in the United States of America of Midatech Pharma PLC, has signed this Registration Statement on Form S-8 on this 8
  th
  day of December, 2016.
  Midatech Pharma PLC
  By:
  /s/ John Petrolino
  Name:
  John Petrolino
  Title:
  General Counsel and Chief Compliance Officer
  7
  EXHIBIT INDEX
  Exhibit No.
  Description of Exhibit
  3.1
  Articles of Association of Midatech Pharma PLC (filed as Exhibit 3.1 to the Registrant's Registration Statement on Form F-4 (File No. 333-206305), filed with the Commission on August 11, 2015, and incorporated herein by reference).
  4.1
  Specimen certificate representing ordinary shares of Midatech Pharma PLC (filed as Exhibit 4.1 to the Registrant's Registration Statement on Form F-4 (File No. 333-206305), filed with the Commission on August 11, 2015, as amended, and incorporated herein by reference).
  4.2
  Deposit Agreement dated December 4, 2015, by and among Midatech Pharma PLC, Deutsche Bank Trust Company Americas, as depositary, and all owners and holders from time to time of American Depositary Shares issued thereunder (filed as Exhibit (a) to the Registrant's Registration Statement on Form F-6 (File No. 333-207186), filed with the Commission on September 29, 2015, as amended on October 27, 2015, and incorporated herein by reference).
  4.3
  Form of American Depositary Receipt (included in Exhibit 4.2).
  5.1*
  Opinion of Gateley Plc.
  23.1*
  Consent of BDO LLP, independent registered public accounting firm.
  23.4*
  Consent of Gateley Plc (included in Exhibit 5.1).
  24.1*
  Power of Attorney (included on the signature page).
  99.1*
  Midatech Pharma PLC 2016 U.S. Option Plan
  *
  Filed herewith.
  8