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  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>As filed with the Securities and Exchange Commission
  on March 17, 2022</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: right"><B>Registration No. 333-&nbsp;&nbsp;&nbsp;&nbsp;</B>&nbsp;&nbsp;&nbsp;&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: right"><B></B></P>
  
  <!-- Field: Rule-Page --><DIV STYLE="width: 100%"><DIV STYLE="font-size: 1pt; border-top: Black 2pt solid; border-bottom: Black 1pt solid">&nbsp;</DIV></DIV><!-- Field: /Rule-Page -->
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: right"><B></B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center"><B>&nbsp;</B></P>
  
  
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center"><B>UNITED STATES</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center"><B>SECURITIES AND EXCHANGE COMMISSION</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center"><B>Washington, D.C. 20549</B></P>
  
  <P STYLE="text-align: center; font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center"><B>FORM S-8</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center"><B>REGISTRATION STATEMENT</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center"><B>UNDER</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center"><B>THE SECURITIES ACT OF 1933</B></P>
  
  <P STYLE="text-align: center; font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center"><B>SeqLL Inc.</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center">(Exact name of registrant as specified in its charter)</P>
  
  <P STYLE="text-align: center; font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt">&nbsp;</P>
  
  <TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
    <TR>
      <TD STYLE="border-bottom: Black 1.5pt solid; vertical-align: top; padding-top: 0.25pt; padding-right: 0.25pt; padding-left: 0.25pt; font-size: 10pt; text-align: center; width: 32%"><FONT STYLE="font-size: 10pt"><B>Delaware</B></FONT></TD>
      <TD STYLE="padding-bottom: 1.5pt; width: 2%">&nbsp;</TD>
      <TD STYLE="text-align: center; border-bottom: Black 1.5pt solid; padding: 0.25pt 0.25pt 1.5pt; vertical-align: bottom; width: 32%"><B>3826</B></TD>
      <TD STYLE="padding-bottom: 1.5pt; width: 2%">&nbsp;</TD>
      <TD STYLE="border-bottom: Black 1.5pt solid; vertical-align: top; padding-top: 0.25pt; padding-right: 0.25pt; padding-left: 0.25pt; font-size: 10pt; text-align: center; width: 32%"><FONT STYLE="font-size: 10pt"><B>46-5319744</B></FONT></TD></TR>
    <TR>
      <TD STYLE="vertical-align: top; padding: 0.25pt">
      <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">(State or other jurisdiction of</P>
      <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">incorporation or organization)</P></TD>
      <TD>&nbsp;</TD>
      <TD STYLE="padding: 0.25pt; vertical-align: top; font-size: 10pt; text-align: center"><FONT STYLE="font-size: 10pt">(Primary Standard Industrial Classification Code Number)</FONT></TD>
      <TD>&nbsp;</TD>
      <TD STYLE="vertical-align: top; padding: 0.25pt">
      <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">(I.R.S. Employer</P>
      <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">Identification No.)</P></TD></TR>
    <TR>
      <TD STYLE="padding: 0.25pt">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD STYLE="vertical-align: top; padding: 0.25pt">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD STYLE="vertical-align: top; padding: 0.25pt">&nbsp;</TD></TR>
    <TR>
      <TD STYLE="vertical-align: top; padding: 0.25pt">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD STYLE="vertical-align: top; padding: 0.25pt">
      <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>317 New Boston St, Suite 210</B></P>
      <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>Woburn, MA 01801</B></P>
      <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>(781) 460-6016</B></P></TD>
      <TD>&nbsp;</TD>
      <TD STYLE="vertical-align: bottom; padding: 0.25pt">&nbsp;</TD></TR>
    <TR STYLE="vertical-align: top">
      <TD COLSPAN="5" STYLE="padding: 0.25pt; font-size: 10pt; text-align: center"><FONT STYLE="font-size: 10pt">(Address, including zip code, and telephone number, including area code, of Registrant&rsquo;s principal executive offices)</FONT></TD></TR>
    </TABLE>
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center"><B>SeqLL Inc. 2014 Equity Incentive Plan</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center">(Full title of the plans)</P>
  
  <P STYLE="text-align: center; font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center"><B>Daniel Jones</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center"><B>SeqLL Inc.</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center"><B>3 Federal Street</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center"><B>Billerica, MA 01821</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center"><B>(781) 460-6016</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center">(Name, address, including zip code, and telephone
  number, including area code, of agent for service)</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center"><I>&nbsp;</I></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center"><I>With a copy to:</I></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center"><B>&nbsp;</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center"><B>Eric M. Hellige, Esq</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center"><B>Pryor Cashman LLP</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center"><B>7 Times Square</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center"><B>New&nbsp;York, NY 10036</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center"><B>Tel: (212) 421-4100</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Indicate by check mark whether the registrant is a large accelerated
  filer, an accelerated filer, a non-accelerated filer, a smaller reporting company or an emerging growth company. See the definitions of
  &ldquo;large accelerated filer,&rdquo; &ldquo;accelerated filer,&rdquo; &ldquo;smaller reporting company,&rdquo; and &ldquo;emerging growth
  company&rdquo; in Rule 12b-2 of the Exchange Act.</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
  
  <TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
    <TR STYLE="vertical-align: bottom">
      <TD STYLE="font-size: 10pt; width: 19%"><FONT STYLE="font-size: 10pt">Large accelerated filer</FONT></TD>
      <TD STYLE="width: 1%">&nbsp;</TD>
      <TD STYLE="font-size: 10pt; width: 46%"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#9744;</FONT></TD>
      <TD STYLE="width: 1%">&nbsp;</TD>
      <TD STYLE="font-size: 10pt; width: 25%"><FONT STYLE="font-size: 10pt">Accelerated filer</FONT></TD>
      <TD STYLE="width: 1%">&nbsp;</TD>
      <TD STYLE="font-size: 10pt; width: 7%"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#9744;</FONT></TD></TR>
    <TR>
      <TD>&nbsp;</TD>
      <TD COLSPAN="2">&nbsp;</TD>
      <TD COLSPAN="2">&nbsp;</TD>
      <TD COLSPAN="2">&nbsp;</TD></TR>
    <TR STYLE="vertical-align: bottom">
      <TD STYLE="font-size: 10pt"><FONT STYLE="font-size: 10pt">Non-accelerated filer</FONT></TD>
      <TD>&nbsp;</TD>
      <TD STYLE="font-size: 10pt"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#9746;</FONT></TD>
      <TD>&nbsp;</TD>
      <TD STYLE="font-size: 10pt"><FONT STYLE="font-size: 10pt">Smaller reporting company</FONT></TD>
      <TD>&nbsp;</TD>
      <TD STYLE="font-size: 10pt"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#9746;</FONT></TD></TR>
    <TR>
      <TD>&nbsp;</TD>
      <TD COLSPAN="2">&nbsp;</TD>
      <TD COLSPAN="2">&nbsp;</TD>
      <TD COLSPAN="2">&nbsp;</TD></TR>
    <TR STYLE="vertical-align: bottom">
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD STYLE="font-size: 10pt"><FONT STYLE="font-size: 10pt">Emerging growth company</FONT></TD>
      <TD>&nbsp;</TD>
      <TD STYLE="font-size: 10pt"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#9746;</FONT></TD></TR>
    </TABLE>
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">If an emerging growth company, indicate by check mark if the registrant
  has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant
  to Section 7(a)(2)(B) of the Securities Act. <FONT STYLE="font-family: Times New Roman, Times, Serif">&#9744;</FONT></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><FONT STYLE="font-family: Times New Roman, Times, Serif">&nbsp;</FONT></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><FONT STYLE="font-family: Times New Roman, Times, Serif"></FONT></P>
  
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  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><FONT STYLE="font-family: Times New Roman, Times, Serif"></FONT></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><FONT STYLE="font-family: Times New Roman, Times, Serif">&nbsp;</FONT></P>
  
  
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  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>PART I</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>&nbsp;</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>INFORMATION REQUIRED IN THE PROSPECTUS</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>&nbsp;</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in"><FONT STYLE="background-color: white">The information
  specified in Item&nbsp;1 and Item&nbsp;2 of Part&nbsp;I of Form&nbsp;S-8&nbsp;is omitted from this Registration Statement on Form&nbsp;S-8&nbsp;(the
  &ldquo;<B>Registration Statement</B>&rdquo;) in accordance with the provisions of Rule&nbsp;428 under the Securities Act of 1933, as amended
  (the &ldquo;<B>Securities Act</B>&rdquo;) and the introductory note to Part&nbsp;I of Form&nbsp;S-8.&nbsp;The documents containing the
  information specified in Part&nbsp;I of Form&nbsp;S-8&nbsp;will be delivered to the participants in the equity benefit plans covered by
  this Registration Statement as specified by Rule&nbsp;428(b)(1) under the Securities Act.</FONT></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"></P>
  
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  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>PART II</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>&nbsp;</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>INFORMATION REQUIRED IN THE REGISTRATION STATEMENT</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>&nbsp;</B></P>
  
  <TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
  <TD STYLE="width: 0"></TD><TD STYLE="width: 45pt"><B>Item 3.</B></TD><TD><B>Incorporation of Documents by Reference.</B></TD></TR></TABLE>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 24.5pt">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in; background-color: white"><FONT STYLE="background-color: white">SeqLL Inc.
  (the &ldquo;<B>Registrant</B>&rdquo;) hereby incorporates by reference into this Registration Statement the following documents previously
  filed with the Securities and Exchange Commission (the &ldquo;<B>Commission</B>&rdquo;):</FONT></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; text-indent: 0.5in; margin-left: 0.5in; text-align: left; margin-top: 0pt; margin-bottom: 0pt">(a) <FONT STYLE="background-color: white">The Registrant&rsquo;s <A HREF="http://www.sec.gov/Archives/edgar/data/1605888/000121390021045678/f424b40821_seqllinc.htm">Prospectus</A> dated August 26, 2021, filed with the Commission pursuant to Rule 424(b) under the Securities Act, relating to the Registration Statement on Form&nbsp;S-1,&nbsp;as amended (File&nbsp;No.&nbsp;</FONT><FONT STYLE="font-family: Times New Roman, Times, Serif">333-254886</FONT><FONT STYLE="background-color: white">),&nbsp;which contains the Registrant&rsquo;s audited financial statements for the latest fiscal year for which such statements have been filed;</FONT></P>
  
  
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0.5in">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0.5in; text-indent: 0.5in"><FONT STYLE="background-color: white">(b) The
  Registrant&rsquo;s Quarterly Report on <A HREF="http://www.sec.gov/ix?doc=/Archives/edgar/data/1605888/000121390021059587/f10q0921_seqllinc.htm">Form 10-Q</A> for the quarter ended September 30, 2021, filed with the Commission on November 16, 2021;
  </FONT></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0.5in; text-indent: 0.5in">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0.5in; text-indent: 0.5in"><FONT STYLE="background-color: white">(c) The
  Registrant&rsquo;s Current Report on <A HREF="http://www.sec.gov/Archives/edgar/data/1605888/000121390021045913/ea146704-8k_seqllinc.htm">Form 8-K</A> filed with the Commission on August 31, 2021 (to the extent filed and not furnished); and</FONT></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0.5in; text-indent: 0.5in">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0.5in; text-indent: 0.5in">(d) <FONT STYLE="background-color: white">The
  description of the Registrant&rsquo;s common stock contained in the Company&rsquo;s Registration Statement on <A HREF="http://www.sec.gov/Archives/edgar/data/1605888/000121390021044735/ea144839-8a12b_seqll.htm">Form&nbsp;8-A</A>&nbsp;(File&nbsp;No.&nbsp;001-40760)&nbsp;filed
  with the Commission on August&nbsp;25, 2021, pursuant to Section&nbsp;12(b) of the Securities Exchange Act of 1934, as amended (the &ldquo;<B>Exchange
  Act</B>&rdquo;), including any amendment or report filed for the purpose of updating such description.</FONT></P>
  
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 24.5pt; background-color: white">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in; background-color: white">In addition, all documents
  filed by the Registrant pursuant to Sections 13(a), 13(c), 14 or 15(d) of the&nbsp;Exchange Act (excluding any portions thereof furnished
  by the Registrant, including, but not limited to, information furnished under Item 2.02 and Item 7.01 and any exhibits relating to Item
  2.02 or Item 7.01 furnished under Item 9.01 of Form&nbsp;8-K&nbsp;and any certification required by 18 U.S.C. &sect; 1350), subsequent
  to the filing of this Registration Statement and prior to the filing of a post-effective amendment which indicates that all securities
  offered hereby have been sold or which deregisters all securities then remaining unsold, shall be deemed to be incorporated by reference
  into this Registration Statement and to be a part hereof from the date of filing of such documents.</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 24.5pt; background-color: white">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in; background-color: white">Any statement contained
  in this Registration Statement or in a document incorporated or deemed to be incorporated by reference in this Registration Statement
  shall be deemed to be modified or superseded for purposes of this Registration Statement to the extent that a statement contained in this
  Registration Statement or in any subsequently filed document that also is deemed to be incorporated by reference in this Registration
  Statement modifies or supersedes such statement.</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 24.5pt"><B>&nbsp;</B></P>
  
  <TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
  <TD STYLE="width: 0"></TD><TD STYLE="width: 45pt"><B>Item 4.</B></TD><TD><B>Description of Securities.</B></TD></TR></TABLE>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 24.5pt">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">Not applicable</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 24.5pt">&nbsp;</P>
  
  <TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
  <TD STYLE="width: 0"></TD><TD STYLE="width: 45pt"><B>Item 5.</B></TD><TD><B>Interests of Named Experts and Counsel.</B></TD></TR></TABLE>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 24.5pt">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">Not applicable</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 24.5pt">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 24.5pt"></P>
  
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  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 24.5pt">&nbsp;</P>
  
  <TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
  <TD STYLE="width: 0"></TD><TD STYLE="width: 45pt"><B>Item 6.</B></TD><TD><B>Indemnification of Directors and Officers.</B></TD></TR></TABLE>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B>&nbsp;</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in; background-color: white">Section&nbsp;102 of the General Corporation Law
  of the State of Delaware permits a corporation to eliminate the personal liability of directors of a corporation to the corporation or
  its stockholders for monetary damages for a breach of fiduciary duty as a director, except for breaches of the director&rsquo;s duty of
  loyalty to the corporation or its stockholders, acts or omissions not in good faith or which involve intentional misconduct or a knowing
  violation of a law, authorizations of the payments of a dividend or approval of a stock repurchase or redemption in violation of Delaware
  corporate law or for any transactions from which the director derived an improper personal benefit. The Registrant&rsquo;s certificate
  of incorporation provides that no director will be liable to the Registrant or its stockholders for monetary damages for breach of fiduciary
  duties as a director, subject to the same exceptions as described above. The Registrant also maintains standard insurance policies that
  provide coverage (1)&nbsp;to its directors and officers against loss arising from claims made by reason of breach of duty or other wrongful
  act and (2)&nbsp;to the Registrant with respect to indemnification payments we may make to such officers and directors.</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 24pt">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in; background-color: white">Section&nbsp;145 of the General Corporation Law
  of the State of Delaware provides that a corporation has the power to indemnify a director, officer, employee, or agent of the corporation
  and certain other persons serving at the request of the corporation in related capacities against expenses (including attorneys&rsquo;
  fees), judgments, fines and amounts paid in settlements actually and reasonably incurred by the person in connection with a threatened,
  pending, or completed action, suit or proceeding to which he or she is or is threatened to be made a party by reason of such position,
  if such person acted in good faith and in a manner he or she reasonably believed to be in or not opposed to the best interests of the
  corporation, and, in any criminal action or proceeding, had no reasonable cause to believe his or her conduct was unlawful, except that,
  in the case of actions brought by or in the right of the corporation, indemnification is limited to expenses (including attorneys&rsquo;
  fees) actually and reasonably incurred by the person in connection with defense or settlement of such action or suit and no indemnification
  shall be made with respect to any claim, issue, or matter as to which such person shall have been adjudged to be liable to the corporation
  unless and only to the extent that the Court of Chancery or other adjudicating court determines that, despite the adjudication of liability
  but in view of all of the circumstances of the case, such person is fairly and reasonably entitled to indemnity for such expenses which
  the Court of Chancery or such other court shall deem proper. In addition, to the extent that a present or former director or officer of
  a corporation has been successful on the merits or otherwise in defense of any action, suit, or proceeding described above (or claim,
  issue, or matter therein), such person shall be indemnified against expenses (including attorneys&rsquo; fees) actually and reasonably
  incurred by such person in connection therewith. Expenses (including attorneys&rsquo; fees) incurred by an officer or director in defending
  any civil, criminal, administrative, or investigative action, suit, or proceeding may be advanced by the corporation upon receipt of an
  undertaking by such person to repay such amount if it is ultimately determined that such person is not entitled to indemnification by
  the corporation under Section&nbsp;145 of the General Corporation Law of the State of Delaware. The Registrant&rsquo;s amended and restated
  certificate of incorporation provides that the Registrant will, to the fullest extent permitted by law, indemnify any person made or threatened
  to be made a party to an action or proceeding by reason of the fact that he or she (or his or her testators or intestate) is or was our
  director or officer or serves or served at any other corporation, partnership, joint venture, trust or other enterprise in a similar capacity
  or as an employee or agent at our request, including service with respect to employee benefit plans maintained or sponsored by us, against
  expenses (including attorneys&rsquo;), judgments, fines, penalties and amounts paid in settlement incurred in connection with the investigation,
  preparation to defend, or defense of such action, suit, proceeding, or claim. However, the Registrant is not required to indemnify or
  advance expenses in connection with any action, suit, proceeding, claim, or counterclaim initiated by the Registrant or on its behalf
  .. The Registrant&rsquo;s amended and restated bylaws provide that the Registrant will indemnify and hold harmless each person who was
  or is a party or threatened to be made a party to any action, suit, or proceeding by reason of the fact that he or she is or was our director
  or officer, or is or was serving at our request in a similar capacity of another corporation, partnership, joint venture, trust or other
  enterprise, including service with respect to employee benefit plans (whether the basis of such action, suit, or proceeding is an action
  in an official capacity as a director or officer or in any other capacity while serving as a director of officer) to the fullest extent
  authorized by the Delaware General Corporation Law against all expense, liability and loss (including attorney&rsquo;s fees, judgments,
  fines, ERISA excise taxes, or penalties and amounts paid in settlement) reasonably incurred or suffered by such person in connection with
  such action, suit or proceeding, and this indemnification continues after such person has ceased to be an officer or director and inures
  to the benefit of such person&rsquo;s heirs, executors and administrators. The indemnification rights also include the right generally
  to be advanced expenses, subject to any undertaking required under Delaware General Corporation Law, and the right generally to recover
  expenses to enforce an indemnification claim or to defend specified suits with respect to advances of indemnification expenses.</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 24.5pt">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 24.5pt"></P>
  
  <!-- Field: Page; Sequence: 4; Value: 1 -->
      <DIV STYLE="margin-top: 12pt; margin-bottom: 6pt; border-bottom: Black 1.5pt solid"><P STYLE="font: 10pt Times New Roman, Times, Serif; text-align: center; margin-top: 0pt; margin-bottom: 0pt">II-<!-- Field: Sequence; Type: Arabic; Name: PageNo -->2<!-- Field: /Sequence --></P></DIV>
      <DIV STYLE="break-before: page; margin-top: 6pt; margin-bottom: 12pt"><P STYLE="margin: 0pt">&nbsp;</P></DIV>
      <!-- Field: /Page -->
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 24.5pt">&nbsp;</P>
  
  <TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
  <TD STYLE="width: 0"></TD><TD STYLE="width: 45pt"><B>Item 7.</B></TD><TD><B>Exemption from Registration Claimed.</B></TD></TR></TABLE>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 24.5pt">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">Not applicable.</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
  
  <TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
  <TD STYLE="width: 0"></TD><TD STYLE="width: 45pt"><B>Item 8.</B></TD><TD><B>Exhibits.</B></TD></TR></TABLE>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 24.5pt">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">The following exhibits are filed as part of this
  Registration Statement:</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 24.5pt">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"></P>
  
  <TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
    <TR STYLE="vertical-align: bottom">
      <TD STYLE="border-bottom: black 1.5pt solid; font-size: 10pt; text-align: left; width: 10%"><FONT STYLE="font-size: 10pt"><B>Exhibit<BR>
  Number</B></FONT></TD>
      <TD STYLE="width: 1%">&nbsp;</TD>
      <TD STYLE="text-align: center; border-bottom: black 1.5pt solid; font-size: 10pt; width: 89%"><FONT STYLE="font-size: 10pt"><B>Description of Document</B></FONT></TD></TR>
    <TR>
      <TD STYLE="text-align: center">&nbsp;</TD>
      <TD COLSPAN="2">&nbsp;</TD></TR>
    <TR STYLE="background-color: rgb(204,238,255)">
      <TD STYLE="vertical-align: top; font-size: 10pt; text-align: center"><FONT STYLE="font-size: 10pt">4.1</FONT></TD>
      <TD STYLE="vertical-align: bottom">&nbsp;</TD>
      <TD STYLE="vertical-align: top; font-size: 10pt"><A HREF="http://www.sec.gov/Archives/edgar/data/1605888/000114420419027563/tv519463_ex4-1.htm"><FONT STYLE="font-size: 10pt">Specimen Common Stock Certificate (incorporated by reference to Exhibit 4.1 to the Registrant&rsquo;s Registration Statement on Form S-1 (File No. <FONT STYLE="font-family: Times New Roman, Times, Serif">333-254886)</FONT></FONT></A></TD></TR>
    <TR STYLE="background-color: White">
      <TD STYLE="vertical-align: top; font-size: 10pt; text-align: center">&nbsp;</TD>
      <TD STYLE="vertical-align: bottom; font-size: 10pt">&nbsp;</TD>
      <TD STYLE="vertical-align: top; font-size: 10pt">&nbsp;</TD></TR>
    <TR STYLE="background-color: rgb(204,238,255)">
      <TD STYLE="vertical-align: top; font-size: 10pt; text-align: center"><FONT STYLE="font-size: 10pt">5.1*</FONT></TD>
      <TD STYLE="vertical-align: bottom">&nbsp;</TD>
      <TD STYLE="vertical-align: top; font-size: 10pt"><A HREF="ea156866ex5-1_seqllinc.htm"><FONT STYLE="font-size: 10pt">Opinion of Pryor Cashman LLP, with respect to the legality of the securities being registered</FONT></A></TD></TR>
    <TR STYLE="background-color: White">
      <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
      <TD STYLE="vertical-align: bottom">&nbsp;</TD>
      <TD STYLE="vertical-align: top">&nbsp;</TD></TR>
    <TR STYLE="background-color: rgb(204,238,255)">
      <TD STYLE="vertical-align: top; font-size: 10pt; text-align: center"><FONT STYLE="font-size: 10pt">23.1*</FONT></TD>
      <TD STYLE="vertical-align: bottom">&nbsp;</TD>
      <TD STYLE="vertical-align: top; font-size: 10pt"><A HREF="ea156866ex23-1_seqllinc.htm"><FONT STYLE="font-size: 10pt">Consent of Wolf&nbsp;&nbsp;&amp; Company, P.C. independent registered accounting firm</FONT></A></TD></TR>
    <TR STYLE="background-color: White">
      <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
      <TD STYLE="vertical-align: bottom">&nbsp;</TD>
      <TD STYLE="vertical-align: top">&nbsp;</TD></TR>
    <TR STYLE="background-color: rgb(204,238,255)">
      <TD STYLE="vertical-align: top; font-size: 10pt; text-align: center"><FONT STYLE="font-size: 10pt">23.2*</FONT></TD>
      <TD STYLE="vertical-align: bottom">&nbsp;</TD>
      <TD STYLE="vertical-align: top; font-size: 10pt"><A HREF="ea156866ex5-1_seqllinc.htm"><FONT STYLE="font-size: 10pt">Consent of Pryor Cashman LLP (included in the opinion filed as Exhibit 5.1)</FONT></A></TD></TR>
    <TR STYLE="background-color: White">
      <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
      <TD STYLE="vertical-align: bottom">&nbsp;</TD>
      <TD STYLE="vertical-align: top">&nbsp;</TD></TR>
    <TR STYLE="background-color: rgb(204,238,255)">
      <TD STYLE="vertical-align: top; font-size: 10pt; text-align: center"><FONT STYLE="font-size: 10pt">23.3*</FONT></TD>
      <TD STYLE="vertical-align: bottom">&nbsp;</TD>
      <TD STYLE="vertical-align: top; font-size: 10pt"><A HREF="#a_001"><FONT STYLE="font-size: 10pt">Power of Attorney of the directors of the Registrant (contained in the signature pages hereto)</FONT></A></TD></TR>
    <TR STYLE="background-color: White">
      <TD STYLE="vertical-align: top; font-size: 10pt; text-align: center">&nbsp;</TD>
      <TD STYLE="vertical-align: bottom; font-size: 10pt">&nbsp;</TD>
      <TD STYLE="vertical-align: top; font-size: 10pt">&nbsp;</TD></TR>
    <TR STYLE="background-color: rgb(204,238,255)">
      <TD STYLE="font-size: 10pt; text-align: center"><FONT STYLE="font-size: 10pt">99.1</FONT></TD>
      <TD>&nbsp;</TD>
      <TD STYLE="vertical-align: top; font-size: 10pt"><A HREF="http://www.sec.gov/Archives/edgar/data/1605888/000121390021018894/fs12021ex10-1_seqllinc.htm"><FONT STYLE="font-size: 10pt">SeqLL Inc. 2014 Equity Incentive Plan as amended (incorporated by reference to Exhibit 10.1 to the Registrant&rsquo;s Registration Statement on Form S-1 (File No. <FONT STYLE="font-family: Times New Roman, Times, Serif">333-254886)</FONT></FONT></A></TD></TR>
    <TR STYLE="background-color: White">
      <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
      <TD STYLE="vertical-align: bottom">&nbsp;</TD>
      <TD STYLE="vertical-align: top; font-size: 10pt">&nbsp;</TD></TR>
    <TR STYLE="background-color: rgb(204,238,255)">
      <TD STYLE="vertical-align: top; font-size: 10pt; text-align: center"><FONT STYLE="font-size: 10pt">107.1*</FONT></TD>
      <TD STYLE="vertical-align: bottom">&nbsp;</TD>
      <TD STYLE="vertical-align: top; font-size: 10pt"><A HREF="ea156866ex-fee_seqllinc.htm"><FONT STYLE="font-size: 10pt">Filing Fee Table</FONT></A></TD></TR>
    </TABLE>
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B>&nbsp;</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B></B></P>
  
  <!-- Field: Rule-Page --><DIV STYLE="width: 25%"><DIV STYLE="font-size: 1pt; border-top: Black 1.5pt solid">&nbsp;</DIV></DIV><!-- Field: /Rule-Page -->
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B></B></P>
  
  <TABLE CELLPADDING="0" CELLSPACING="0" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0in; margin-bottom: 0in; width: 100%"><TR STYLE="vertical-align: top; text-align: justify">
  <TD STYLE="width: 0in"></TD><TD STYLE="width: 0.25in; text-align: left"><B>*</B></TD><TD STYLE="text-align: justify">Filed herewith.</TD>
  </TR></TABLE>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
  
  <TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
  <TD STYLE="width: 0"></TD><TD STYLE="width: 45pt"><B>Item 9.</B></TD><TD><B>Undertakings.</B></TD></TR></TABLE>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 24.5pt">&nbsp;</P>
  
  <TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
  <TD STYLE="width: 0.5in"></TD><TD STYLE="width: 0.5in">(a)</TD><TD>The undersigned Registrant hereby undertakes:</TD></TR></TABLE>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 1.25in">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0.5in; text-indent: 0.5in">(1)  To
  file, during any period in which offers or sales are being made of securities registered hereby, a post-effective amendment to this Registration
  Statement which shall include any material information with respect to the plan of distribution not previously disclosed in the Registration
  Statement or any material change to such information in the Registration Statement;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0.5in; text-indent: 0.5in">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0.5in; text-indent: 0.5in">(2)  That,
  for the purpose of determining any liability under the Securities Act, each such post-effective amendment shall be deemed to be a new
  registration statement relating to the securities offered therein, and the offering of such securities at that time shall be deemed to
  be the initial <I>bona fide</I> offering thereof; and</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0.5in; text-indent: 0.5in">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0.5in; text-indent: 0.5in">(3)  To
  remove from registration by means of a post-effective amendment any of the securities being registered which remain unsold at the termination
  of the offering.</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 1in">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0.5in; text-indent: 0.5in">(b)  The
  undersigned Registrant hereby further undertakes that, for purposes of determining any liability under the Securities Act, each filing
  of the Registrant&rsquo;s annual report pursuant to Section 13(a) or 15(d) of the Exchange Act that is incorporated by reference in the
  Registration Statement shall be deemed to be a new registration statement relating to the securities offered therein, and the offering
  of such securities at that time shall be deemed to be the initial <I>bona fide</I> offering thereof.</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0.5in; text-indent: 0.5in">(c) Insofar
  as indemnification for liabilities arising under the Securities Act may be permitted to directors, officers and controlling persons of
  the Registrant pursuant to the foregoing provisions, or otherwise, the Registrant has been advised that in the opinion of the Commission
  such indemnification is against public policy as expressed in the Securities Act and is, therefore, unenforceable. In the event that a
  claim for indemnification against such liabilities (other than the payment by the Registrant of expenses incurred or paid by a director,
  officer or controlling person of the Registrant in the successful defense of any action, suit or proceeding) is asserted by such director,
  officer or controlling person in connection with the securities being registered, the Registrant will, unless in the opinion of its counsel
  the matter has been settled by controlling precedent, submit to a court of appropriate jurisdiction the question whether such indemnification
  by it is against public policy as expressed in the Securities Act and will be governed by the final adjudication of such issue.</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&nbsp;</P>
  
  
  <!-- Field: Page; Sequence: 5; Value: 1 -->
      <DIV STYLE="margin-top: 12pt; margin-bottom: 6pt; border-bottom: Black 1.5pt solid"><P STYLE="font: 10pt Times New Roman, Times, Serif; text-align: center; margin-top: 0pt; margin-bottom: 0pt">II-<!-- Field: Sequence; Type: Arabic; Name: PageNo -->3<!-- Field: /Sequence --></P></DIV>
      <DIV STYLE="break-before: page; margin-top: 6pt; margin-bottom: 12pt"><P STYLE="margin: 0pt">&nbsp;</P></DIV>
      <!-- Field: /Page -->
  
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>&nbsp;</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><A NAME="a_001"></A><B>SIGNATURES</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>&nbsp;</B></P>
  
  <P STYLE="text-align: left; font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">Pursuant to the requirements of the Securities
  Act of 1933, as amended, the Registrant certifies that it has reasonable grounds to believe it meets all of the requirements for filing
  on Form S-8 and has duly caused this Registration Statement to be signed on its behalf by the undersigned thereunto duly authorized, in
  Billerica, Massachusetts, on the 17th day of March, 2022.</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 10.25pt; text-indent: 0.5in">&nbsp;</P>
  
  <TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
    <TR STYLE="vertical-align: top">
      <TD STYLE="font-size: 10pt">&nbsp;</TD>
      <TD COLSPAN="2" STYLE="font-size: 10pt"><FONT STYLE="font-size: 10pt"><B>SEQLL INC.</B></FONT></TD></TR>
    <TR STYLE="vertical-align: top">
      <TD STYLE="font-size: 10pt">&nbsp;</TD>
      <TD COLSPAN="2" STYLE="font-size: 10pt">&nbsp;</TD></TR>
    <TR STYLE="vertical-align: top">
      <TD STYLE="width: 60%; font-size: 10pt">&nbsp;</TD>
      <TD STYLE="width: 4%; font-size: 10pt"><FONT STYLE="font-size: 10pt">By:</FONT></TD>
      <TD STYLE="border-bottom: black 1.5pt solid; width: 36%; font-size: 10pt"><FONT STYLE="font-size: 10pt">/s/ Daniel Jones</FONT></TD></TR>
    <TR STYLE="vertical-align: top">
      <TD STYLE="font-size: 10pt">&nbsp;</TD>
      <TD STYLE="font-size: 10pt">&nbsp;</TD>
      <TD STYLE="font-size: 10pt"><FONT STYLE="font-size: 10pt">Daniel Jones<BR>
  Chief Executive Officer</FONT></TD></TR>
    </TABLE>
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 10.25pt; text-indent: 0.5in">&nbsp;</P>
  
  <P STYLE="text-align: left; font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">Pursuant to the requirements of the Securities
  Exchange Act of 1934, this report has been signed by the following persons in the capacities and on the dates indicated.</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
  
  <TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
    <TR STYLE="vertical-align: bottom">
      <TD STYLE="width: 28%; border-bottom: black 1.5pt solid; text-align: center"><FONT STYLE="font-size: 10pt"><B>Signature</B></FONT></TD>
      <TD STYLE="white-space: nowrap; width: 1%">&nbsp;</TD>
      <TD STYLE="width: 45%; border-bottom: black 1.5pt solid; text-align: center"><FONT STYLE="font-size: 10pt"><B>Title</B></FONT></TD>
      <TD STYLE="white-space: nowrap; width: 1%">&nbsp;</TD>
      <TD STYLE="width: 25%; border-bottom: black 1.5pt solid; text-align: center"><FONT STYLE="font-size: 10pt"><B>Date</B></FONT></TD></TR>
    <TR STYLE="vertical-align: bottom">
      <TD STYLE="text-align: center">&nbsp;</TD>
      <TD STYLE="white-space: nowrap">&nbsp;</TD>
      <TD STYLE="text-align: center">&nbsp;</TD>
      <TD STYLE="white-space: nowrap">&nbsp;</TD>
      <TD STYLE="text-align: center">&nbsp;</TD></TR>
    <TR STYLE="vertical-align: bottom">
      <TD STYLE="border-bottom: black 1.5pt solid"><FONT STYLE="font-size: 10pt">/s/ Daniel Jones </FONT></TD>
      <TD STYLE="white-space: nowrap">&nbsp;</TD>
      <TD><FONT STYLE="font-size: 10pt">Chief Executive Officer and Chairman </FONT></TD>
      <TD STYLE="white-space: nowrap">&nbsp;</TD>
      <TD STYLE="text-align: center"><FONT STYLE="font-size: 10pt">March 17, 2022 </FONT></TD></TR>
    <TR STYLE="vertical-align: bottom">
      <TD><FONT STYLE="font-size: 10pt">Daniel Jones </FONT></TD>
      <TD STYLE="white-space: nowrap">&nbsp;</TD>
      <TD><FONT STYLE="font-size: 10pt"><I>(Principal Executive Officer)</I></FONT></TD>
      <TD STYLE="white-space: nowrap">&nbsp;</TD>
      <TD>&nbsp;</TD></TR>
    <TR STYLE="vertical-align: bottom">
      <TD>&nbsp;</TD>
      <TD STYLE="white-space: nowrap">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD STYLE="white-space: nowrap">&nbsp;</TD>
      <TD STYLE="text-align: center">&nbsp;</TD></TR>
    <TR STYLE="vertical-align: bottom">
      <TD STYLE="border-bottom: black 1.5pt solid"><FONT STYLE="font-size: 10pt">/s/ John W. Kennedy </FONT></TD>
      <TD STYLE="white-space: nowrap">&nbsp;</TD>
      <TD><FONT STYLE="font-size: 10pt">Chief Financial Officer </FONT></TD>
      <TD STYLE="white-space: nowrap">&nbsp;</TD>
      <TD STYLE="text-align: center"><FONT STYLE="font-size: 10pt">March 17, 2022 </FONT></TD></TR>
    <TR STYLE="vertical-align: bottom">
      <TD><FONT STYLE="font-size: 10pt">John W. Kennedy </FONT></TD>
      <TD STYLE="white-space: nowrap">&nbsp;</TD>
      <TD><FONT STYLE="font-size: 10pt"><I>(Principal Financial and Accounting Officer)</I></FONT></TD>
      <TD STYLE="white-space: nowrap">&nbsp;</TD>
      <TD>&nbsp;</TD></TR>
    <TR STYLE="vertical-align: bottom">
      <TD>&nbsp;</TD>
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      <TD STYLE="border-bottom: black 1.5pt solid"><FONT STYLE="font-size: 10pt">/s/ Douglas Miscoll &nbsp; &nbsp;</FONT></TD>
      <TD STYLE="white-space: nowrap">&nbsp;</TD>
      <TD><FONT STYLE="font-size: 10pt">Director </FONT></TD>
      <TD STYLE="white-space: nowrap">&nbsp;</TD>
      <TD STYLE="text-align: center"><FONT STYLE="font-size: 10pt">March 17, 2022</FONT></TD></TR>
    <TR STYLE="vertical-align: bottom">
      <TD><FONT STYLE="font-size: 10pt">Douglas Miscoll </FONT></TD>
      <TD STYLE="white-space: nowrap">&nbsp;</TD>
      <TD>&nbsp;</TD>
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      <TD STYLE="border-bottom: black 1.5pt solid"><FONT STYLE="font-size: 10pt">/s/ David Pfeffer</FONT></TD>
      <TD STYLE="white-space: nowrap">&nbsp;</TD>
      <TD><FONT STYLE="font-size: 10pt">Director </FONT></TD>
      <TD STYLE="white-space: nowrap">&nbsp;</TD>
      <TD STYLE="text-align: center"><FONT STYLE="font-size: 10pt">March 17, 2022 </FONT></TD></TR>
    <TR STYLE="vertical-align: bottom">
      <TD><FONT STYLE="font-size: 10pt">David Pfeffer </FONT></TD>
      <TD STYLE="white-space: nowrap">&nbsp;</TD>
      <TD>&nbsp;</TD>
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    <TR STYLE="vertical-align: bottom">
      <TD STYLE="border-bottom: black 1.5pt solid"><FONT STYLE="font-size: 10pt">/s/ Dr. Patrice Milos</FONT></TD>
      <TD STYLE="white-space: nowrap">&nbsp;</TD>
      <TD>Director </TD>
      <TD STYLE="white-space: nowrap">&nbsp;</TD>
      <TD STYLE="text-align: center"><FONT STYLE="font-size: 10pt">March 17, 2022 </FONT></TD></TR>
    <TR STYLE="vertical-align: bottom">
      <TD><FONT STYLE="font-size: 10pt">Dr. Patrice Milos</FONT></TD>
      <TD STYLE="white-space: nowrap">&nbsp;</TD>
      <TD>&nbsp;</TD>
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metadata_filer: {"company-data": {"conformed-name": "SeqLL, Inc.", "cik": "0001605888", "assigned-sic": "3826", "irs-number": "465319744", "state-of-incorporation": "DE", "fiscal-year-end": "1231"}, "filing-values": {"form-type": "S-8", "act": "33", "file-number": "333-263670", "film-number": "22750850"}, "business-address": {"street1": "317 NEW BOSTON STREET", "street2": "SUITE 210", "city": "WOBURN", "state": "MA", "zip": "01801", "phone": "(781) 817-3755"}, "mail-address": {"street1": "317 NEW BOSTON STREET", "street2": "SUITE 210", "city": "WOBURN", "state": "MA", "zip": "01801"}}
text: As filed with the Securities and Exchange Commission
  on March 17, 2022
  Registration No. 333-
  UNITED STATES
  SECURITIES AND EXCHANGE COMMISSION
  Washington, D.C. 20549
  FORM S-8
  REGISTRATION STATEMENT
  UNDER
  THE SECURITIES ACT OF 1933
  SeqLL Inc.
  (Exact name of registrant as specified in its charter)
  Delaware
  3826
  46-5319744
  (State or other jurisdiction of
  incorporation or organization)
  (Primary Standard Industrial Classification Code Number)
  (I.R.S. Employer
  Identification No.)
  317 New Boston St, Suite 210
  Woburn, MA 01801
  (781) 460-6016
  (Address, including zip code, and telephone number, including area code, of Registrant's principal executive offices)
  SeqLL Inc. 2014 Equity Incentive Plan
  (Full title of the plans)
  Daniel Jones
  SeqLL Inc.
  3 Federal Street
  Billerica, MA 01821
  (781) 460-6016
  (Name, address, including zip code, and telephone
  number, including area code, of agent for service)
  With a copy to:
  Eric M. Hellige, Esq
  Pryor Cashman LLP
  7 Times Square
  New York, NY 10036
  Tel: (212) 421-4100
  Indicate by check mark whether the registrant is a large accelerated
  filer, an accelerated filer, a non-accelerated filer, a smaller reporting company or an emerging growth company. See the definitions of
  "large accelerated filer," "accelerated filer," "smaller reporting company," and "emerging growth
  company" in Rule 12b-2 of the Exchange Act.
  Large accelerated filer
  ☐
  Accelerated filer
  ☐
  Non-accelerated filer
  ☒
  Smaller reporting company
  ☒
  Emerging growth company
  ☒
  If an emerging growth company, indicate by check mark if the registrant
  has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant
  to Section 7(a)(2)(B) of the Securities Act.
  ☐
  PART I
  INFORMATION REQUIRED IN THE PROSPECTUS
  The information
  specified in Item 1 and Item 2 of Part I of Form S-8 is omitted from this Registration Statement on Form S-8 (the
  "
  Registration Statement
  ") in accordance with the provisions of Rule 428 under the Securities Act of 1933, as amended
  (the "
  Securities Act
  ") and the introductory note to Part I of Form S-8. The documents containing the
  information specified in Part I of Form S-8 will be delivered to the participants in the equity benefit plans covered by
  this Registration Statement as specified by Rule 428(b)(1) under the Securities Act.
  1
  PART II
  INFORMATION REQUIRED IN THE REGISTRATION STATEMENT
  Item 3.
  Incorporation of Documents by Reference.
  SeqLL Inc.
  (the "
  Registrant
  ") hereby incorporates by reference into this Registration Statement the following documents previously
  filed with the Securities and Exchange Commission (the "
  Commission
  "):
  (a)
  The Registrant's
  Prospectus
  dated August 26, 2021, filed with the Commission pursuant to Rule 424(b) under the Securities Act, relating to the Registration Statement on Form S-1, as amended (File No.
  333-254886
  ), which contains the Registrant's audited financial statements for the latest fiscal year for which such statements have been filed;
  (b) The
  Registrant's Quarterly Report on
  Form 10-Q
  for the quarter ended September 30, 2021, filed with the Commission on November 16, 2021;
  (c) The
  Registrant's Current Report on
  Form 8-K
  filed with the Commission on August 31, 2021 (to the extent filed and not furnished); and
  (d)
  The
  description of the Registrant's common stock contained in the Company's Registration Statement on
  Form 8-A
  (File No. 001-40760) filed
  with the Commission on August 25, 2021, pursuant to Section 12(b) of the Securities Exchange Act of 1934, as amended (the "
  Exchange
  Act
  "), including any amendment or report filed for the purpose of updating such description.
  In addition, all documents
  filed by the Registrant pursuant to Sections 13(a), 13(c), 14 or 15(d) of the Exchange Act (excluding any portions thereof furnished
  by the Registrant, including, but not limited to, information furnished under Item 2.02 and Item 7.01 and any exhibits relating to Item
  2.02 or Item 7.01 furnished under Item 9.01 of Form 8-K and any certification required by 18 U.S.C. § 1350), subsequent
  to the filing of this Registration Statement and prior to the filing of a post-effective amendment which indicates that all securities
  offered hereby have been sold or which deregisters all securities then remaining unsold, shall be deemed to be incorporated by reference
  into this Registration Statement and to be a part hereof from the date of filing of such documents.
  Any statement contained
  in this Registration Statement or in a document incorporated or deemed to be incorporated by reference in this Registration Statement
  shall be deemed to be modified or superseded for purposes of this Registration Statement to the extent that a statement contained in this
  Registration Statement or in any subsequently filed document that also is deemed to be incorporated by reference in this Registration
  Statement modifies or supersedes such statement.
  Item 4.
  Description of Securities.
  Not applicable
  Item 5.
  Interests of Named Experts and Counsel.
  Not applicable
  II-
  1
  Item 6.
  Indemnification of Directors and Officers.
  Section 102 of the General Corporation Law
  of the State of Delaware permits a corporation to eliminate the personal liability of directors of a corporation to the corporation or
  its stockholders for monetary damages for a breach of fiduciary duty as a director, except for breaches of the director's duty of
  loyalty to the corporation or its stockholders, acts or omissions not in good faith or which involve intentional misconduct or a knowing
  violation of a law, authorizations of the payments of a dividend or approval of a stock repurchase or redemption in violation of Delaware
  corporate law or for any transactions from which the director derived an improper personal benefit. The Registrant's certificate
  of incorporation provides that no director will be liable to the Registrant or its stockholders for monetary damages for breach of fiduciary
  duties as a director, subject to the same exceptions as described above. The Registrant also maintains standard insurance policies that
  provide coverage (1) to its directors and officers against loss arising from claims made by reason of breach of duty or other wrongful
  act and (2) to the Registrant with respect to indemnification payments we may make to such officers and directors.
  Section 145 of the General Corporation Law
  of the State of Delaware provides that a corporation has the power to indemnify a director, officer, employee, or agent of the corporation
  and certain other persons serving at the request of the corporation in related capacities against expenses (including attorneys'
  fees), judgments, fines and amounts paid in settlements actually and reasonably incurred by the person in connection with a threatened,
  pending, or completed action, suit or proceeding to which he or she is or is threatened to be made a party by reason of such position,
  if such person acted in good faith and in a manner he or she reasonably believed to be in or not opposed to the best interests of the
  corporation, and, in any criminal action or proceeding, had no reasonable cause to believe his or her conduct was unlawful, except that,
  in the case of actions brought by or in the right of the corporation, indemnification is limited to expenses (including attorneys'
  fees) actually and reasonably incurred by the person in connection with defense or settlement of such action or suit and no indemnification
  shall be made with respect to any claim, issue, or matter as to which such person shall have been adjudged to be liable to the corporation
  unless and only to the extent that the Court of Chancery or other adjudicating court determines that, despite the adjudication of liability
  but in view of all of the circumstances of the case, such person is fairly and reasonably entitled to indemnity for such expenses which
  the Court of Chancery or such other court shall deem proper. In addition, to the extent that a present or former director or officer of
  a corporation has been successful on the merits or otherwise in defense of any action, suit, or proceeding described above (or claim,
  issue, or matter therein), such person shall be indemnified against expenses (including attorneys' fees) actually and reasonably
  incurred by such person in connection therewith. Expenses (including attorneys' fees) incurred by an officer or director in defending
  any civil, criminal, administrative, or investigative action, suit, or proceeding may be advanced by the corporation upon receipt of an
  undertaking by such person to repay such amount if it is ultimately determined that such person is not entitled to indemnification by
  the corporation under Section 145 of the General Corporation Law of the State of Delaware. The Registrant's amended and restated
  certificate of incorporation provides that the Registrant will, to the fullest extent permitted by law, indemnify any person made or threatened
  to be made a party to an action or proceeding by reason of the fact that he or she (or his or her testators or intestate) is or was our
  director or officer or serves or served at any other corporation, partnership, joint venture, trust or other enterprise in a similar capacity
  or as an employee or agent at our request, including service with respect to employee benefit plans maintained or sponsored by us, against
  expenses (including attorneys'), judgments, fines, penalties and amounts paid in settlement incurred in connection with the investigation,
  preparation to defend, or defense of such action, suit, proceeding, or claim. However, the Registrant is not required to indemnify or
  advance expenses in connection with any action, suit, proceeding, claim, or counterclaim initiated by the Registrant or on its behalf
  .. The Registrant's amended and restated bylaws provide that the Registrant will indemnify and hold harmless each person who was
  or is a party or threatened to be made a party to any action, suit, or proceeding by reason of the fact that he or she is or was our director
  or officer, or is or was serving at our request in a similar capacity of another corporation, partnership, joint venture, trust or other
  enterprise, including service with respect to employee benefit plans (whether the basis of such action, suit, or proceeding is an action
  in an official capacity as a director or officer or in any other capacity while serving as a director of officer) to the fullest extent
  authorized by the Delaware General Corporation Law against all expense, liability and loss (including attorney's fees, judgments,
  fines, ERISA excise taxes, or penalties and amounts paid in settlement) reasonably incurred or suffered by such person in connection with
  such action, suit or proceeding, and this indemnification continues after such person has ceased to be an officer or director and inures
  to the benefit of such person's heirs, executors and administrators. The indemnification rights also include the right generally
  to be advanced expenses, subject to any undertaking required under Delaware General Corporation Law, and the right generally to recover
  expenses to enforce an indemnification claim or to defend specified suits with respect to advances of indemnification expenses.
  II-
  2
  Item 7.
  Exemption from Registration Claimed.
  Not applicable.
  Item 8.
  Exhibits.
  The following exhibits are filed as part of this
  Registration Statement:
  Exhibit
  Number
  Description of Document
  4.1
  Specimen Common Stock Certificate (incorporated by reference to Exhibit 4.1 to the Registrant's Registration Statement on Form S-1 (File No.
  333-254886)
  5.1*
  Opinion of Pryor Cashman LLP, with respect to the legality of the securities being registered
  23.1*
  Consent of Wolf  & Company, P.C. independent registered accounting firm
  23.2*
  Consent of Pryor Cashman LLP (included in the opinion filed as Exhibit 5.1)
  23.3*
  Power of Attorney of the directors of the Registrant (contained in the signature pages hereto)
  99.1
  SeqLL Inc. 2014 Equity Incentive Plan as amended (incorporated by reference to Exhibit 10.1 to the Registrant's Registration Statement on Form S-1 (File No.
  333-254886)
  107.1*
  Filing Fee Table
  *
  Filed herewith.
  Item 9.
  Undertakings.
  (a)
  The undersigned Registrant hereby undertakes:
  (1)  To
  file, during any period in which offers or sales are being made of securities registered hereby, a post-effective amendment to this Registration
  Statement which shall include any material information with respect to the plan of distribution not previously disclosed in the Registration
  Statement or any material change to such information in the Registration Statement;
  (2)  That,
  for the purpose of determining any liability under the Securities Act, each such post-effective amendment shall be deemed to be a new
  registration statement relating to the securities offered therein, and the offering of such securities at that time shall be deemed to
  be the initial
  bona fide
  offering thereof; and
  (3)  To
  remove from registration by means of a post-effective amendment any of the securities being registered which remain unsold at the termination
  of the offering.
  (b)  The
  undersigned Registrant hereby further undertakes that, for purposes of determining any liability under the Securities Act, each filing
  of the Registrant's annual report pursuant to Section 13(a) or 15(d) of the Exchange Act that is incorporated by reference in the
  Registration Statement shall be deemed to be a new registration statement relating to the securities offered therein, and the offering
  of such securities at that time shall be deemed to be the initial
  bona fide
  offering thereof.
  (c) Insofar
  as indemnification for liabilities arising under the Securities Act may be permitted to directors, officers and controlling persons of
  the Registrant pursuant to the foregoing provisions, or otherwise, the Registrant has been advised that in the opinion of the Commission
  such indemnification is against public policy as expressed in the Securities Act and is, therefore, unenforceable. In the event that a
  claim for indemnification against such liabilities (other than the payment by the Registrant of expenses incurred or paid by a director,
  officer or controlling person of the Registrant in the successful defense of any action, suit or proceeding) is asserted by such director,
  officer or controlling person in connection with the securities being registered, the Registrant will, unless in the opinion of its counsel
  the matter has been settled by controlling precedent, submit to a court of appropriate jurisdiction the question whether such indemnification
  by it is against public policy as expressed in the Securities Act and will be governed by the final adjudication of such issue.
  II-
  3
  SIGNATURES
  Pursuant to the requirements of the Securities
  Act of 1933, as amended, the Registrant certifies that it has reasonable grounds to believe it meets all of the requirements for filing
  on Form S-8 and has duly caused this Registration Statement to be signed on its behalf by the undersigned thereunto duly authorized, in
  Billerica, Massachusetts, on the 17th day of March, 2022.
  SEQLL INC.
  By:
  /s/ Daniel Jones
  Daniel Jones
  Chief Executive Officer
  Pursuant to the requirements of the Securities
  Exchange Act of 1934, this report has been signed by the following persons in the capacities and on the dates indicated.
  Signature
  Title
  Date
  /s/ Daniel Jones
  Chief Executive Officer and Chairman
  March 17, 2022
  Daniel Jones
  (Principal Executive Officer)
  /s/ John W. Kennedy
  Chief Financial Officer
  March 17, 2022
  John W. Kennedy
  (Principal Financial and Accounting Officer)
  /s/ Douglas Miscoll
  Director
  March 17, 2022
  Douglas Miscoll
  /s/ David Pfeffer
  Director
  March 17, 2022
  David Pfeffer
  /s/ Dr. Patrice Milos
  Director
  March 17, 2022
  Dr. Patrice Milos
  II-4