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  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>As filed with the Securities and Exchange Commission
  on March 5, 2025</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: right"><B>Registration No. 333 - &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</B>&nbsp;</P>
  
  <P STYLE="text-align: center; font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"></P>
  
  <!-- Field: Rule-Page --><DIV STYLE="margin-top: 0pt; margin-bottom: 0pt; width: 100%"><DIV STYLE="font-size: 1pt; border-top: Black 2pt solid; border-bottom: Black 1pt solid">&nbsp;</DIV></DIV><!-- Field: /Rule-Page -->
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; text-align: center; margin-top: 0pt; margin-bottom: 0pt">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>UNITED STATES</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>SECURITIES AND EXCHANGE COMMISSION</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>WASHINGTON, D.C. 20549</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>FORM S-8</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>REGISTRATION STATEMENT</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>UNDER</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>THE SECURITIES ACT OF 1933</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>&nbsp;</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>INSPIRA TECHNOLOGIES OXY B.H.N. LTD.</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">(Exact name of registrant as specified in its charter)</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>
  
  <TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
    <TR STYLE="vertical-align: top">
      <TD STYLE="width: 49%; border-bottom: black 1.5pt solid; padding-top: 0.25pt; padding-right: 0.25pt; padding-left: 0.25pt; text-align: center"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt"><B>State of Israel</B></FONT></TD>
      <TD STYLE="width: 2%; padding-top: 0.25pt; padding-right: 0.25pt; padding-left: 0.25pt">&nbsp;</TD>
      <TD STYLE="width: 49%; border-bottom: black 1.5pt solid; padding-top: 0.25pt; padding-right: 0.25pt; padding-left: 0.25pt; text-align: center"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt"><B>Not applicable</B></FONT></TD></TR>
    <TR STYLE="vertical-align: top">
      <TD STYLE="padding-top: 0.25pt; padding-right: 0.25pt; padding-left: 0.25pt; text-align: center"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">(State or other jurisdiction of<BR>
  incorporation or organization)</FONT></TD>
      <TD STYLE="padding-top: 0.25pt; padding-right: 0.25pt; padding-left: 0.25pt">&nbsp;</TD>
      <TD STYLE="padding-top: 0.25pt; padding-right: 0.25pt; padding-left: 0.25pt; text-align: center"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">(I.R.S. Employer <BR>
  Identification No.)</FONT></TD></TR>
    </TABLE>
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>&nbsp;</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>2 Ha-Tidhar St., Ra&rsquo;anana, 4366504 Israel</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">(Address of Principal Executive Offices)</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>Inspira Technologies OXY B.H.N. LTD. </B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>Amended and Restated 2019 Equity Incentive Plan</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">(Full title of the plan)</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>&nbsp;</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>Puglisi &amp; Associates</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>850 Library Ave., Suite 204, Newark, DE 19711</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>Tel: (302) 738-6680 </B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">(Name, Address and Telephone Number of Agent for
  Service)</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">COPIES TO:</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>
  
  <TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
    <TR STYLE="vertical-align: top">
      <TD STYLE="width: 50%; padding: 0.25pt">
      <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">Oded Har-Even, Esq.</P>
      <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">Ron Ben-Bassat, Esq.</P>
      <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">Sullivan &amp; Worcester LLP</P>
      <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">1251 Avenue of the Americas</P>
      <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">New York, NY 10020</P>
      <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">Tel: (212)-660-3000</P></TD>
      <TD STYLE="width: 50%; padding: 0.25pt">
      <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">Adv. Reut Alfiah</P>
      <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">Adv. Gal Cohen</P>
      <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">Sullivan &amp; Worcester Tel-Aviv (Har-Even &amp;
      Co.)</P>
      <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">28 HaArba&rsquo;a St. HaArba&rsquo;a Towers</P>
      <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">North Tower, 35th floor</P>
      <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">Tel-Aviv, Israel 6473925</P>
      <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">Tel: +972 74-758-0480</P></TD></TR>
    </TABLE>
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Indicate by check mark whether the registrant is a large accelerated
  filer, an accelerated filer, a non-accelerated filer, a smaller reporting company or an emerging growth company. See definitions of &ldquo;large
  accelerated filer,&rdquo; &ldquo;accelerated filer,&rdquo; &ldquo;smaller reporting company&rdquo; and &ldquo;emerging growth company&rdquo;
  in Rule 12b-2 of the Exchange Act.</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
  
  <TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
    <TR STYLE="vertical-align: top">
      <TD STYLE="width: 23%"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">Large accelerated filer &#9744;</FONT></TD>
      <TD STYLE="width: 46%">&nbsp;</TD>
      <TD STYLE="width: 31%"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">Accelerated filer &#9744;</FONT></TD></TR>
    <TR STYLE="vertical-align: top">
      <TD><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">Non-accelerated filer &#9746;</FONT></TD>
      <TD>&nbsp;</TD>
      <TD><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">Smaller reporting company &#9744;</FONT></TD></TR>
    <TR STYLE="vertical-align: top">
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">Emerging growth company &#9746;</FONT></TD></TR>
    </TABLE>
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">If an emerging growth company, indicate by check mark if the registrant
  has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant
  to Section 7(a)(2)(B) of the Securities Act. &#9744;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"></P>
  
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  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"></P>
  
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  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B>&nbsp;</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>EXPLANATORY NOTE</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B>&nbsp;</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">On August 5, 2021, Inspira Technologies Oxy B.H.N.
  Ltd., or the Registrant or the Company, filed a Registration Statement on Form S-8 (File No. 333-259057), or the Original Registration
  Statement, with the Securities and Exchange Commission, or the SEC, to register an aggregate of 4,180,898 ordinary shares, no par value
  per share, of the Company, or the Ordinary Shares, that may be issued pursuant to the Company&rsquo;s 2019 Equity Incentive Plan, or the
  2019 Plan. On March 15, 2024, the Company filed an additional Registration Statement on Form S-8 (File No. 333-277980) with the SEC to
  register an additional 2,997,671 Ordinary Shares that may be issued pursuant to the 2019 Plan.</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">The 2019 Plan was originally adopted by the
  board of directors of the Company in November 2019, amended in September 2021, and further amended and restated in March 2025, or
  the Amended and Restated 2019 Plan.</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">The Company is filing this Registration Statement
  on Form S-8, or this Registration Statement, to register an additional 3,000,000 Ordinary Shares reserved for issuance in connection with
  securities awards which may hereafter be granted under the Amended and Restated 2019 Plan.</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">Pursuant to General Instruction E to Form S-8,
  the contents of the Original Registration Statement are incorporated herein by reference, except for Items 3 and 8 of Part II of the Original
  Registration Statement, which are being updated by this Registration Statement.</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B>&nbsp;</B></P>
  
  
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  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>PART I</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>&nbsp;</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>INFORMATION REQUIRED IN THE SECTION 10(a) PROSPECTUS</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">The information specified in Item 1 and Item 2
  of Part I of Form S-8 is omitted from this Registration Statement. The documents containing the information specified in Part I of Form
  S-8 will be delivered to the participants in the Plan covered by this Registration Statement as specified by&nbsp;Rule 428(b)(1) under
  the&nbsp;Securities Act of 1933, as amended, or the Securities Act.</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in"></P>
  
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  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in"><B>&nbsp;</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>PART II</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>&nbsp;</B></P>
  
  <TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
    <TR STYLE="vertical-align: top">
      <TD STYLE="white-space: nowrap; width: 72px"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt"><B>ITEM 3.</B></FONT></TD>
      <TD STYLE="text-align: justify"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt"><B>INCORPORATION OF DOCUMENTS BY REFERENCE</B></FONT></TD></TR>
    </TABLE>
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">The following documents filed by the Company with
  the SEC are incorporated by reference into this Registration Statement:</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">(a) Our Annual Report on <U STYLE="text-decoration: none"><A HREF="https://www.sec.gov/Archives/edgar/data/1837493/000121390024025316/ea0202167-20f_inspira.htm">Form 20-F</A></U> for the
  fiscal year ended December 31, 2023, filed with the SEC on March 25, 2024;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">(b) Our Reports on Form 6-K furnished on&nbsp;<A HREF="http://www.sec.gov/Archives/edgar/data/1837493/000121390024025319/ea0202483-6k_inspira.htm">March
  25, 2024</A>&nbsp;(with respect to the first paragraph, the section titled &ldquo;Full Year 2023 Financial Results&rdquo; and the section
  titled &ldquo;Forward-Looking Statements&rdquo; in the press release attached as Exhibit 99.1),&nbsp;<A HREF="http://www.sec.gov/Archives/edgar/data/1837493/000121390024028248/ea0203004-6k_inspira.htm">April
  1, 2024</A>,&nbsp;<A HREF="http://www.sec.gov/Archives/edgar/data/1837493/000121390024029603/ea0203238-6k_inspira.htm">April 3, 2024</A>&nbsp;(with
  respect to the first two paragraphs and the section titled &ldquo;Forward-Looking Statements&rdquo;&nbsp;in the press release attached
  as Exhibit 99.1),&nbsp;<A HREF="http://www.sec.gov/Archives/edgar/data/1837493/000121390024031588/ea0203565-6k_inspira.htm">April 9, 2024</A>,&nbsp;<A HREF="http://www.sec.gov/Archives/edgar/data/1837493/000121390024031743/ea0203633-6k_inspira.htm">April
  10, 2024</A>&nbsp;(with respect to the first five paragraphs and the section titled &ldquo;Forward-Looking Statements&rdquo; in the press
  release attached as Exhibit 99.1),&nbsp;<A HREF="http://www.sec.gov/Archives/edgar/data/1837493/000121390024033583/ea0204064-6k_inspira.htm">April
  17, 2024</A>&nbsp;(with respect to the first four paragraphs and the section titled &ldquo;Forward-Looking Statements&rdquo; in the press
  release attached as Exhibit 99.1),&nbsp;<A HREF="http://www.sec.gov/Archives/edgar/data/1837493/000121390024035965/ea0204624-6k_inspira.htm">April
  25, 2024</A>&nbsp;(with respect to the first three paragraphs and the section titled &ldquo;Forward-Looking Statements&rdquo; in the press
  release attached as Exhibit 99.1),&nbsp;<A HREF="http://www.sec.gov/Archives/edgar/data/1837493/000121390024038793/ea0205143-6k_inspira.htm">May
  2,&nbsp;2024</A>,&nbsp;<A HREF="http://www.sec.gov/Archives/edgar/data/1837493/000121390024046836/ea0206933-6k_inspira.htm">May 28,&nbsp;2024</A>&nbsp;(with
  respect to the first paragraph and the section titled &ldquo;Forward-Looking Statements&rdquo; in the press release attached as Exhibit
  99.1),&nbsp;<A HREF="http://www.sec.gov/Archives/edgar/data/1837493/000121390024052263/ea0207815-6k_inspira.htm">June 13, 2024</A>&nbsp;(with
  respect to the first, second and fourth paragraphs and the section titled &ldquo;Forward-Looking Statements&rdquo; in the press release
  attached as Exhibit 99.1),&nbsp;<A HREF="http://www.sec.gov/Archives/edgar/data/1837493/000121390024053164/ea0207959-6k_inspiratech.htm">June
  17, 2024</A>,&nbsp;<A HREF="http://www.sec.gov/Archives/edgar/data/1837493/000121390024053563/ea0208045-6ka1_inspiratech.htm">June&nbsp;18,
  2024</A>,&nbsp;<A HREF="http://www.sec.gov/Archives/edgar/data/1837493/000121390024054050/ea0208154-6k_inspira.htm">June 20, 2024</A>,&nbsp;<A HREF="http://www.sec.gov/Archives/edgar/data/1837493/000121390024060637/ea0209273-6k_inspira.htm">July
  11, 2024</A>&nbsp;(with respect to the first paragraph and the section titled &ldquo;Forward-Looking Statements&rdquo; in the press release
  attached as Exhibit 99.1),&nbsp;<A HREF="http://www.sec.gov/Archives/edgar/data/1837493/000101376224002693/ea0210269-6k_inspira.htm">July
  30, 2024</A>&nbsp;(with respect to the first, third, fourth, fifth and sixth paragraphs and the section titled &ldquo;Forward-Looking
  Statements&rdquo; in the press release attached as Exhibit 99.1),&nbsp;<A HREF="http://www.sec.gov/Archives/edgar/data/1837493/000121390024067923/ea0211237-6k_inspira.htm">August
  13, 2024</A>&nbsp;(with respect to the first two paragraphs and the section titled &ldquo;Forward-Looking Statements&rdquo; in the press
  release attached as Exhibit 99.1),&nbsp;<A HREF="http://www.sec.gov/Archives/edgar/data/1837493/000121390024069610/ea0211236-6k_inspira.htm">August
  15, 2024</A>,&nbsp;<A HREF="http://www.sec.gov/Archives/edgar/data/1837493/000121390024071647/ea0212123-6k_inspira.htm">August 22, 2024</A>&nbsp;(with
  respect to the first two paragraphs and the section titled &ldquo;Forward-Looking Statements&rdquo; in the press release attached as Exhibit
  99.1),&nbsp;<A HREF="http://www.sec.gov/Archives/edgar/data/1837493/000121390024073140/ea0212643-6k_inspira.htm">August 28, 2024</A>&nbsp;(with
  respect to the first paragraph and the sections titled &ldquo;Future Plans,&rdquo; &ldquo;Inspira&trade; business overview,&rdquo; and
  &ldquo;Forward-Looking Statements&rdquo; in the press release attached as Exhibit 99.1), <A HREF="http://www.sec.gov/Archives/edgar/data/1837493/000121390024078554/ea0214460-6k_inspira.htm">September
  13, 2024</A> (with respect to the first two paragraphs and the section titled &ldquo;Forward-Looking Statements&rdquo; in the press release
  attached as Exhibit 99.1), <A HREF="http://www.sec.gov/Archives/edgar/data/1837493/000121390024086610/ea0217153-6k_inspira.htm">October
  9, 2024</A> (with respect to the first three paragraphs and the section titled &ldquo;Forward-Looking Statements&rdquo;), <A HREF="http://www.sec.gov/Archives/edgar/data/1837493/000121390024090369/ea0218523-6k_inspira.htm">October
  24, 2024</A> (with respect to the first three paragraphs and the section titled &ldquo;Forward-Looking Statements&rdquo; in the press
  release attached as Exhibit 99.1), <A HREF="http://www.sec.gov/Archives/edgar/data/1837493/000121390024096304/ea0220809-6k_inspira.htm">November
  12, 2024</A>, <A HREF="http://www.sec.gov/Archives/edgar/data/1837493/000121390024102136/ea0222413-6k_inspira.htm">November 25, 2024</A>,
  <A HREF="http://www.sec.gov/Archives/edgar/data/1837493/000121390024105238/ea0223523-6k_inspira.htm">December 4, 2024</A> (with respect
  to the first two paragraphs and the section titled &ldquo;Forward-Looking Statements&rdquo; in the press release attached as Exhibit 99.1),
  <A HREF="http://www.sec.gov/Archives/edgar/data/1837493/000121390024107160/ea0224204-6k_inspira.htm">December 10, 2024</A> (with respect
  to the first three paragraphs and the section titled &ldquo;Forward-Looking Statements&rdquo; in the press release attached as Exhibit
  99.1), <A HREF="http://www.sec.gov/Archives/edgar/data/1837493/000121390024109042/ea0224872-6k_inspira.htm">December 16, 2024</A> (with
  respect to the first three paragraphs and the section titled &ldquo;Forward-Looking Statements&rdquo; in the press release attached as
  Exhibit 99.1), <A HREF="http://www.sec.gov/Archives/edgar/data/1837493/000121390024113079/ea0226021-6k_inspira.htm">December 27, 2024</A>,
  <A HREF="http://www.sec.gov/Archives/edgar/data/1837493/000121390024113476/ea0226340-6k_inspira.htm">December 30, 2024</A>, <A HREF="http://www.sec.gov/Archives/edgar/data/1837493/000121390025001399/ea0226965-6k_inspira.htm">January
  7, 2025</A> (with respect to the first four paragraphs and the section titled &ldquo;Forward-Looking Statements&rdquo; in the press release
  attached as Exhibit 99.1), and <A HREF="http://www.sec.gov/Archives/edgar/data/1837493/000121390025002298/ea0227344-6k_inspira.htm">January
  10, 2025</A> (with respect to the first three paragraphs, fifth paragraph and the section titled &ldquo;Forward-Looking Statements&rdquo;
  in the press release attached as Exhibit 99.1), <A HREF="http://www.sec.gov/Archives/edgar/data/1837493/000121390025003417/ea0227585-6k_inspira.htm">January
  14, 2025</A> (with respect to the first four paragraphs and the section titled &ldquo;Forward-Looking Statements&rdquo; in the press release
  attached as Exhibit 99.1), <A HREF="https://www.sec.gov/Archives/edgar/data/1837493/000121390025004363/ea0228007-6k_inspira.htm">January
  17, 2025</A>, <A HREF="https://www.sec.gov/Archives/edgar/data/1837493/000121390025004785/ea0228151-6k_inspira.htm">January 21, 2025</A>,
  <A HREF="https://www.sec.gov/Archives/edgar/data/1837493/000121390025006750/ea0228782-6k_inspira.htm">January 27, 2025</A> (with respect
  to the first, second, third and fifth paragraphs and the section titled &ldquo;Forward-Looking Statements&rdquo; in the press release
  attached as Exhibit 99.1), <A HREF="https://www.sec.gov/Archives/edgar/data/1837493/000121390025010277/ea0230007-6k_inspira.htm">February 5, 2025</A> (with respect to the first, second, third and fifth paragraphs and the section titled &ldquo;Forward-Looking
  Statements&rdquo;), <A HREF="https://www.sec.gov/Archives/edgar/data/1837493/000121390025011925/ea0230643-6k_inspira.htm">February 11, 2025</A> (with respect to the first, second, fourth and fifth paragraphs and the section titled &ldquo;Forward-Looking
  Statements&rdquo;) and <A HREF="https://www.sec.gov/Archives/edgar/data/1837493/000121390025019766/ea0233009-6k_inspira.htm">March 4, 2025</A> (with respect to the first, second, fourth and fifth paragraphs and the section titled &ldquo;Forward-Looking
  Statements&rdquo;); and&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">(c) The description of our securities contained
  in <A HREF="https://www.sec.gov/Archives/edgar/data/1837493/000121390024025316/ea020216701ex2-1_inspira.htm">Exhibit 2.1</A> to our Annual
  Report on <A HREF="https://www.sec.gov/Archives/edgar/data/1837493/000121390024025316/ea0202167-20f_inspira.htm">Form 20-F</A> for the fiscal year ended December 31, 2023, filed with the SEC on March 25, 2024, including any amendments or reports
  filed for the purpose of updating such description.</P>
  
  <P STYLE="margin: 0">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in"></P>
  
  <!-- Field: Page; Sequence: 4; Options: NewSection -->
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      <DIV STYLE="break-before: page; margin-top: 6pt; margin-bottom: 12pt"><P STYLE="margin: 0pt">&nbsp;</P></DIV>
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  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">In addition to the foregoing, all documents subsequently
  filed by the Registrant pursuant to Sections 13(a), 13(c), 14 and 15(d) of the Exchange Act and all reports on Form 6-K subsequently filed
  by the Registrant which state that they are incorporated by reference herein,&nbsp;prior to the filing of a post-effective amendment which
  indicates that all securities offered hereunder have been sold or which deregisters all securities then remaining unsold, shall be deemed
  to be incorporated by reference herein and to be part hereof from the date of filing of such documents and reports.</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">Any statement contained in a document incorporated
  or deemed to be incorporated by reference herein shall be deemed to be modified or superseded for purposes of this Registration Statement
  to the extent that a statement herein, or in any subsequently filed document which also is or is deemed to be incorporated by reference,
  modifies or supersedes such statement. Any statement so modified or superseded shall not be deemed, except as so modified or superseded,
  to constitute a part of this Registration Statement.</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&nbsp;</P>
  
  <TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
    <TR STYLE="vertical-align: top">
      <TD STYLE="border-bottom: Black 1.5pt solid"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt"><B>Item 8.</B></FONT></TD>
      <TD STYLE="padding-bottom: 1.5pt">&nbsp;</TD>
      <TD STYLE="border-bottom: Black 1.5pt solid; text-align: justify"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt"><B>Exhibits.</B></FONT></TD></TR>
    <TR STYLE="vertical-align: top; background-color: #CCEEFF">
      <TD STYLE="width: 9%; padding-top: 0.25pt; padding-right: 0.25pt; padding-left: 0.25pt"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">4.1</FONT></TD>
      <TD STYLE="width: 1%; padding-top: 0.25pt; padding-right: 0.25pt; padding-left: 0.25pt">&nbsp;</TD>
      <TD STYLE="width: 90%; padding-top: 0.25pt; padding-right: 0.25pt; padding-left: 0.25pt"><A HREF="http://www.sec.gov/Archives/edgar/data/1837493/000121390021066318/ea152692ex99-1_inspiratech.htm"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">Amended and Restated Articles of Association of Inspira Technologies Oxy B.H.N. Ltd. (incorporated by reference to Exhibit 99.1 to the Company&rsquo;s Report on Form 6-K (File No. 001-40303) filed on December 20, 2021).</FONT></A></TD></TR>
    <TR STYLE="vertical-align: top; background-color: white">
      <TD STYLE="padding-top: 0.25pt; padding-right: 0.25pt; padding-left: 0.25pt">&nbsp;</TD>
      <TD STYLE="padding-top: 0.25pt; padding-right: 0.25pt; padding-left: 0.25pt">&nbsp;</TD>
      <TD STYLE="padding-top: 0.25pt; padding-right: 0.25pt; padding-left: 0.25pt">&nbsp;</TD></TR>
    <TR STYLE="vertical-align: top; background-color: #CCEEFF">
      <TD STYLE="padding-top: 0.25pt; padding-right: 0.25pt; padding-left: 0.25pt"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">5.1*</FONT></TD>
      <TD STYLE="padding-top: 0.25pt; padding-right: 0.25pt; padding-left: 0.25pt">&nbsp;</TD>
      <TD STYLE="padding-top: 0.25pt; padding-right: 0.25pt; padding-left: 0.25pt"><A HREF="ea023315301ex5-1_inspira.htm"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">Opinion of Sullivan &amp; Worcester Tel Aviv (Har-Even &amp; Co.)</FONT></A></TD></TR>
    <TR STYLE="vertical-align: top; background-color: white">
      <TD STYLE="padding-top: 0.25pt; padding-right: 0.25pt; padding-left: 0.25pt">&nbsp;</TD>
      <TD STYLE="padding-top: 0.25pt; padding-right: 0.25pt; padding-left: 0.25pt">&nbsp;</TD>
      <TD STYLE="padding-top: 0.25pt; padding-right: 0.25pt; padding-left: 0.25pt">&nbsp;</TD></TR>
    <TR STYLE="vertical-align: top; background-color: #CCEEFF">
      <TD STYLE="padding-top: 0.25pt; padding-right: 0.25pt; padding-left: 0.25pt"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">23.1*</FONT></TD>
      <TD STYLE="padding-top: 0.25pt; padding-right: 0.25pt; padding-left: 0.25pt">&nbsp;</TD>
      <TD STYLE="padding-top: 0.25pt; padding-right: 0.25pt; padding-left: 0.25pt"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt"><A HREF="ea023315301ex23-1_inspira.htm">Consent of Ziv Haft, member firm of BDO, independent registered public accounting firm.</A></FONT></TD></TR>
    <TR STYLE="vertical-align: top; background-color: white">
      <TD STYLE="padding-top: 0.25pt; padding-right: 0.25pt; padding-left: 0.25pt">&nbsp;</TD>
      <TD STYLE="padding-top: 0.25pt; padding-right: 0.25pt; padding-left: 0.25pt">&nbsp;</TD>
      <TD STYLE="padding-top: 0.25pt; padding-right: 0.25pt; padding-left: 0.25pt">&nbsp;</TD></TR>
    <TR STYLE="vertical-align: top; background-color: #CCEEFF">
      <TD STYLE="padding-top: 0.25pt; padding-right: 0.25pt; padding-left: 0.25pt"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">23.2*</FONT></TD>
      <TD STYLE="padding-top: 0.25pt; padding-right: 0.25pt; padding-left: 0.25pt">&nbsp;</TD>
      <TD STYLE="padding-top: 0.25pt; padding-right: 0.25pt; padding-left: 0.25pt"><A HREF="ea023315301ex5-1_inspira.htm"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">Consent of Sullivan &amp; Worcester Tel Aviv (Har-Even &amp; Co.) (included in the opinion filed as Exhibit 5.1 to this Registration Statement)</FONT></A></TD></TR>
    <TR STYLE="vertical-align: top; background-color: white">
      <TD STYLE="padding-top: 0.25pt; padding-right: 0.25pt; padding-left: 0.25pt">&nbsp;</TD>
      <TD STYLE="padding-top: 0.25pt; padding-right: 0.25pt; padding-left: 0.25pt">&nbsp;</TD>
      <TD STYLE="padding-top: 0.25pt; padding-right: 0.25pt; padding-left: 0.25pt">&nbsp;</TD></TR>
    <TR STYLE="vertical-align: top; background-color: #CCEEFF">
      <TD STYLE="padding-top: 0.25pt; padding-right: 0.25pt; padding-left: 0.25pt"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">24.1*</FONT></TD>
      <TD STYLE="padding-top: 0.25pt; padding-right: 0.25pt; padding-left: 0.25pt">&nbsp;</TD>
      <TD STYLE="padding-top: 0.25pt; padding-right: 0.25pt; padding-left: 0.25pt"><A HREF="#poa_001"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">Power of Attorney (included on signature page)</FONT></A></TD></TR>
    <TR STYLE="vertical-align: top; background-color: white">
      <TD STYLE="padding-top: 0.25pt; padding-right: 0.25pt; padding-left: 0.25pt">&nbsp;</TD>
      <TD STYLE="padding-top: 0.25pt; padding-right: 0.25pt; padding-left: 0.25pt">&nbsp;</TD>
      <TD STYLE="padding-top: 0.25pt; padding-right: 0.25pt; padding-left: 0.25pt">&nbsp;</TD></TR>
    <TR STYLE="vertical-align: top; background-color: #CCEEFF">
      <TD STYLE="padding-top: 0.25pt; padding-right: 0.25pt; padding-left: 0.25pt"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">99.1*</FONT></TD>
      <TD STYLE="padding-top: 0.25pt; padding-right: 0.25pt; padding-left: 0.25pt">&nbsp;</TD>
      <TD STYLE="padding-top: 0.25pt; padding-right: 0.25pt; padding-left: 0.25pt"><A HREF="ea023315301ex99-1_inspira.htm"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">Amended
      and Restated Inspira Technologies Oxy B.H.N. Ltd. 2019 Equity Incentive Plan</FONT></A></TD></TR>
    <TR STYLE="vertical-align: top; background-color: white">
      <TD STYLE="padding-top: 0.25pt; padding-right: 0.25pt; padding-left: 0.25pt">&nbsp;</TD>
      <TD STYLE="padding-top: 0.25pt; padding-right: 0.25pt; padding-left: 0.25pt">&nbsp;</TD>
      <TD STYLE="padding-top: 0.25pt; padding-right: 0.25pt; padding-left: 0.25pt">&nbsp;</TD></TR>
    <TR STYLE="vertical-align: top; background-color: #CCEEFF">
      <TD STYLE="padding-top: 0.25pt; padding-right: 0.25pt; padding-left: 0.25pt"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">107*</FONT></TD>
      <TD STYLE="padding-top: 0.25pt; padding-right: 0.25pt; padding-left: 0.25pt">&nbsp;</TD>
      <TD STYLE="padding-top: 0.25pt; padding-right: 0.25pt; padding-left: 0.25pt"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt"><A HREF="ea023315301ex-fee_inspira.htm">Filing Fee Table.</A></FONT></TD></TR>
    </TABLE>
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
  
  <TABLE CELLPADDING="0" CELLSPACING="0" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; width: 100%"><TR STYLE="vertical-align: top; text-align: justify">
  <TD STYLE="width: 0in"></TD><TD STYLE="width: 0.25in; text-align: left">*</TD><TD STYLE="text-align: justify">Filed herewith.</TD>
  </TR></TABLE>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"></P>
  
  
  
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"></P>
  
  <!-- Field: Page; Sequence: 5 -->
      <DIV STYLE="margin-top: 12pt; margin-bottom: 6pt; border-bottom: Black 1.5pt solid"><P STYLE="font: normal 10pt Times New Roman, Times, Serif; text-align: center; margin-top: 0pt; margin-bottom: 0pt">II-<!-- Field: Sequence; Type: Arabic; Name: PageNo -->2<!-- Field: /Sequence --></P></DIV>
      <DIV STYLE="break-before: page; margin-top: 6pt; margin-bottom: 12pt"><P STYLE="margin: 0pt">&nbsp;</P></DIV>
      <!-- Field: /Page -->
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B>&nbsp;</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>SIGNATURES</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">Pursuant to the requirements of the Securities
  Act, the registrant certifies that it has reasonable grounds to believe that it meets all of the requirements for filing on Form S-8 and
  has duly caused this Registration Statement on Form S-8 to be signed on its behalf by the undersigned, thereunto duly authorized, in Ra&rsquo;anana,
  Israel, on March 5, 2025.</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&nbsp;</P>
  
  <TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
    <TR STYLE="vertical-align: top">
      <TD STYLE="padding-top: 0.25pt; padding-right: 0.25pt; padding-left: 0.25pt">&nbsp;</TD>
      <TD COLSPAN="3" STYLE="padding-top: 0.25pt; padding-right: 0.25pt; padding-left: 0.25pt"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt"><B>INSPIRA TECHNOLOGIES OXY B.H.N. LTD.</B></FONT></TD></TR>
    <TR STYLE="vertical-align: top">
      <TD STYLE="padding-top: 0.25pt; padding-right: 0.25pt; padding-left: 0.25pt">&nbsp;</TD>
      <TD STYLE="padding-top: 0.25pt; padding-right: 0.25pt; padding-left: 0.25pt">&nbsp;</TD>
      <TD COLSPAN="2" STYLE="padding-top: 0.25pt; padding-right: 0.25pt; padding-left: 0.25pt">&nbsp;</TD></TR>
    <TR STYLE="vertical-align: top">
      <TD STYLE="padding-top: 0.25pt; padding-right: 0.25pt; padding-left: 0.25pt">&nbsp;</TD>
      <TD STYLE="padding-top: 0.25pt; padding-right: 0.25pt; padding-left: 0.25pt"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">By: </FONT></TD>
      <TD COLSPAN="2" STYLE="border-bottom: black 1.5pt solid; padding: 0.25pt 0.25pt 0.75pt">/s/ Dagi Ben-Noon</TD></TR>
    <TR STYLE="vertical-align: top">
      <TD STYLE="width: 60%; padding-top: 0.25pt; padding-right: 0.25pt; padding-left: 0.25pt">&nbsp;</TD>
      <TD STYLE="width: 4%; padding-top: 0.25pt; padding-right: 0.25pt; padding-left: 0.25pt">&nbsp;</TD>
      <TD STYLE="width: 5%; padding-top: 0.25pt; padding-right: 0.25pt; padding-left: 0.25pt"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">Name:&nbsp; </FONT></TD>
      <TD STYLE="width: 31%; padding-top: 0.25pt; padding-right: 0.25pt; padding-left: 0.25pt"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">Dagi Ben-Noon</FONT></TD></TR>
    <TR STYLE="vertical-align: top">
      <TD STYLE="padding-top: 0.25pt; padding-right: 0.25pt; padding-left: 0.25pt">&nbsp;</TD>
      <TD STYLE="padding-top: 0.25pt; padding-right: 0.25pt; padding-left: 0.25pt">&nbsp;</TD>
      <TD STYLE="padding-top: 0.25pt; padding-right: 0.25pt; padding-left: 0.25pt"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">Title: </FONT></TD>
      <TD STYLE="padding-top: 0.25pt; padding-right: 0.25pt; padding-left: 0.25pt"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">Chief Executive Officer</FONT></TD></TR>
    </TABLE>
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B>&nbsp;</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><A NAME="poa_001"></A><B>POWER OF ATTORNEY AND SIGNATURES</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">We, the undersigned officers and directors of Inspira
  Technologies Oxy B.H.N. Ltd., hereby severally constitute and appoint Dagi Ben-Noon and Joe Hayon, and each of them individually, our
  true and lawful attorney to sign for us and in our names in the capacities indicated below any and all amendments or supplements, including
  any post-effective amendments, to this Registration Statement on Form S-8 and to file the same, with exhibits thereto and other documents
  in connection therewith, with the Securities and Exchange Commission, granting unto said attorney full power and authority to do and perform
  each and every act and thing requisite or necessary to be done in and about the premises, as fully to all intents and purposes as he or
  she might or could do in person, hereby ratifying and confirming our signatures to said amendments to this Registration Statement signed
  by our said attorney and all else that said attorney may lawfully do and cause to be done by virtue hereof.</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">Pursuant to the requirements of the Securities
  Act, this Registration Statement on Form S-8 has been signed below by the following persons in the capacities and on the dates indicated.</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&nbsp;</P>
  
  <TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
    <TR STYLE="vertical-align: top">
      <TD STYLE="width: 29%; border-bottom: black 1.5pt solid; padding-top: 0.25pt; padding-right: 0.25pt; padding-left: 0.25pt"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt"><B>Signature</B></FONT></TD>
      <TD STYLE="width: 1%; padding-top: 0.25pt; padding-right: 0.25pt; padding-left: 0.25pt">&nbsp;</TD>
      <TD STYLE="width: 54%; border-bottom: black 1.5pt solid; padding-top: 0.25pt; padding-right: 0.25pt; padding-left: 0.25pt; text-align: center"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt"><B>Title</B></FONT></TD>
      <TD STYLE="width: 1%; padding-top: 0.25pt; padding-right: 0.25pt; padding-left: 0.25pt">&nbsp;</TD>
      <TD STYLE="width: 15%; border-bottom: black 1.5pt solid; padding-top: 0.25pt; padding-right: 0.25pt; padding-left: 0.25pt; text-align: center"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt"><B>Date</B></FONT></TD></TR>
    <TR STYLE="vertical-align: top">
      <TD STYLE="padding-top: 0.25pt; padding-right: 0.25pt; padding-left: 0.25pt">&nbsp;</TD>
      <TD STYLE="padding-top: 0.25pt; padding-right: 0.25pt; padding-left: 0.25pt">&nbsp;</TD>
      <TD STYLE="padding-top: 0.25pt; padding-right: 0.25pt; padding-left: 0.25pt">&nbsp;</TD>
      <TD STYLE="padding-top: 0.25pt; padding-right: 0.25pt; padding-left: 0.25pt">&nbsp;</TD>
      <TD STYLE="padding-top: 0.25pt; padding-right: 0.25pt; padding-left: 0.25pt; text-align: center">&nbsp;</TD></TR>
    <TR STYLE="vertical-align: top">
      <TD STYLE="border-bottom: black 1.5pt solid; padding-top: 0.25pt; padding-right: 0.25pt; padding-left: 0.25pt">/s/ Dagi Ben-Noon</TD>
      <TD STYLE="padding-top: 0.25pt; padding-right: 0.25pt; padding-left: 0.25pt">&nbsp;</TD>
      <TD STYLE="padding-top: 0.25pt; padding-right: 0.25pt; padding-left: 0.25pt"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">Chief Executive Officer and Director</FONT></TD>
      <TD STYLE="padding-top: 0.25pt; padding-right: 0.25pt; padding-left: 0.25pt">&nbsp;</TD>
      <TD STYLE="padding-top: 0.25pt; padding-right: 0.25pt; padding-left: 0.25pt; text-align: center"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">March 5, 2025</FONT></TD></TR>
    <TR STYLE="vertical-align: top">
      <TD STYLE="padding-top: 0.25pt; padding-right: 0.25pt; padding-left: 0.25pt"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">Dagi Ben-Noon</FONT></TD>
      <TD STYLE="padding-top: 0.25pt; padding-right: 0.25pt; padding-left: 0.25pt">&nbsp;</TD>
      <TD STYLE="padding-top: 0.25pt; padding-right: 0.25pt; padding-left: 0.25pt"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">(Principal Executive Officer) </FONT></TD>
      <TD STYLE="padding-top: 0.25pt; padding-right: 0.25pt; padding-left: 0.25pt">&nbsp;</TD>
      <TD STYLE="padding-top: 0.25pt; padding-right: 0.25pt; padding-left: 0.25pt; text-align: center">&nbsp;</TD></TR>
    <TR STYLE="vertical-align: top">
      <TD STYLE="padding-top: 0.25pt; padding-right: 0.25pt; padding-left: 0.25pt">&nbsp;</TD>
      <TD STYLE="padding-top: 0.25pt; padding-right: 0.25pt; padding-left: 0.25pt">&nbsp;</TD>
      <TD STYLE="padding-top: 0.25pt; padding-right: 0.25pt; padding-left: 0.25pt">&nbsp;</TD>
      <TD STYLE="padding-top: 0.25pt; padding-right: 0.25pt; padding-left: 0.25pt">&nbsp;</TD>
      <TD STYLE="padding-top: 0.25pt; padding-right: 0.25pt; padding-left: 0.25pt; text-align: center">&nbsp;</TD></TR>
    <TR STYLE="vertical-align: top">
      <TD STYLE="border-bottom: black 1.5pt solid; padding-top: 0.25pt; padding-right: 0.25pt; padding-left: 0.25pt">/s/ Yafit Tehila&nbsp;</TD>
      <TD STYLE="padding-top: 0.25pt; padding-right: 0.25pt; padding-left: 0.25pt">&nbsp;</TD>
      <TD STYLE="padding-top: 0.25pt; padding-right: 0.25pt; padding-left: 0.25pt"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">Chief Financial Officer</FONT></TD>
      <TD STYLE="padding-top: 0.25pt; padding-right: 0.25pt; padding-left: 0.25pt">&nbsp;</TD>
      <TD STYLE="padding-top: 0.25pt; padding-right: 0.25pt; padding-left: 0.25pt; text-align: center"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">March 5, 2025</FONT></TD></TR>
    <TR STYLE="vertical-align: top">
      <TD STYLE="padding-top: 0.25pt; padding-right: 0.25pt; padding-left: 0.25pt"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">Yafit Tehila&nbsp;</FONT></TD>
      <TD STYLE="padding-top: 0.25pt; padding-right: 0.25pt; padding-left: 0.25pt">&nbsp;</TD>
      <TD STYLE="white-space: nowrap; padding-top: 0.25pt; padding-right: 0.25pt; padding-left: 0.25pt"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">(Principal Financial Officer and Principal Accounting Officer) </FONT></TD>
      <TD STYLE="padding-top: 0.25pt; padding-right: 0.25pt; padding-left: 0.25pt">&nbsp;</TD>
      <TD STYLE="padding-top: 0.25pt; padding-right: 0.25pt; padding-left: 0.25pt; text-align: center">&nbsp;</TD></TR>
    <TR STYLE="vertical-align: top">
      <TD STYLE="padding-top: 0.25pt; padding-right: 0.25pt; padding-left: 0.25pt">&nbsp;</TD>
      <TD STYLE="padding-top: 0.25pt; padding-right: 0.25pt; padding-left: 0.25pt">&nbsp;</TD>
      <TD STYLE="padding-top: 0.25pt; padding-right: 0.25pt; padding-left: 0.25pt">&nbsp;</TD>
      <TD STYLE="padding-top: 0.25pt; padding-right: 0.25pt; padding-left: 0.25pt">&nbsp;</TD>
      <TD STYLE="padding-top: 0.25pt; padding-right: 0.25pt; padding-left: 0.25pt; text-align: center">&nbsp;</TD></TR>
    <TR STYLE="vertical-align: top">
      <TD STYLE="border-bottom: black 1.5pt solid; padding-top: 0.25pt; padding-right: 0.25pt; padding-left: 0.25pt">/s/ Joe Hayon</TD>
      <TD STYLE="padding-top: 0.25pt; padding-right: 0.25pt; padding-left: 0.25pt">&nbsp;</TD>
      <TD STYLE="padding-top: 0.25pt; padding-right: 0.25pt; padding-left: 0.25pt"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">President and Director</FONT></TD>
      <TD STYLE="padding-top: 0.25pt; padding-right: 0.25pt; padding-left: 0.25pt">&nbsp;</TD>
      <TD STYLE="padding-top: 0.25pt; padding-right: 0.25pt; padding-left: 0.25pt; text-align: center"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">March 5, 2025</FONT></TD></TR>
    <TR STYLE="vertical-align: top">
      <TD STYLE="padding-top: 0.25pt; padding-right: 0.25pt; padding-left: 0.25pt"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">Joe Hayon</FONT></TD>
      <TD STYLE="padding-top: 0.25pt; padding-right: 0.25pt; padding-left: 0.25pt">&nbsp;</TD>
      <TD STYLE="padding-top: 0.25pt; padding-right: 0.25pt; padding-left: 0.25pt">&nbsp;</TD>
      <TD STYLE="padding-top: 0.25pt; padding-right: 0.25pt; padding-left: 0.25pt">&nbsp;</TD>
      <TD STYLE="padding-top: 0.25pt; padding-right: 0.25pt; padding-left: 0.25pt; text-align: center">&nbsp;</TD></TR>
    <TR STYLE="vertical-align: top">
      <TD STYLE="padding-top: 0.25pt; padding-right: 0.25pt; padding-left: 0.25pt">&nbsp;</TD>
      <TD STYLE="padding-top: 0.25pt; padding-right: 0.25pt; padding-left: 0.25pt">&nbsp;</TD>
      <TD STYLE="padding-top: 0.25pt; padding-right: 0.25pt; padding-left: 0.25pt">&nbsp;</TD>
      <TD STYLE="padding-top: 0.25pt; padding-right: 0.25pt; padding-left: 0.25pt">&nbsp;</TD>
      <TD STYLE="padding-top: 0.25pt; padding-right: 0.25pt; padding-left: 0.25pt; text-align: center">&nbsp;</TD></TR>
    <TR STYLE="vertical-align: top">
      <TD STYLE="border-bottom: black 1.5pt solid; padding-top: 0.25pt; padding-right: 0.25pt; padding-left: 0.25pt">/s/ Tal Parnes&nbsp;</TD>
      <TD STYLE="padding-top: 0.25pt; padding-right: 0.25pt; padding-left: 0.25pt">&nbsp;</TD>
      <TD STYLE="padding-top: 0.25pt; padding-right: 0.25pt; padding-left: 0.25pt"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">Chairman of the Board of Directors</FONT></TD>
      <TD STYLE="padding-top: 0.25pt; padding-right: 0.25pt; padding-left: 0.25pt">&nbsp;</TD>
      <TD STYLE="padding-top: 0.25pt; padding-right: 0.25pt; padding-left: 0.25pt; text-align: center"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">March 5, 2025</FONT></TD></TR>
    <TR STYLE="vertical-align: top">
      <TD STYLE="padding-top: 0.25pt; padding-right: 0.25pt; padding-left: 0.25pt"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">Tal Parnes&nbsp;</FONT></TD>
      <TD STYLE="padding-top: 0.25pt; padding-right: 0.25pt; padding-left: 0.25pt">&nbsp;</TD>
      <TD STYLE="padding-top: 0.25pt; padding-right: 0.25pt; padding-left: 0.25pt">&nbsp;</TD>
      <TD STYLE="padding-top: 0.25pt; padding-right: 0.25pt; padding-left: 0.25pt">&nbsp;</TD>
      <TD STYLE="padding-top: 0.25pt; padding-right: 0.25pt; padding-left: 0.25pt; text-align: center">&nbsp;</TD></TR>
    <TR STYLE="vertical-align: top">
      <TD STYLE="padding-top: 0.25pt; padding-right: 0.25pt; padding-left: 0.25pt">&nbsp;</TD>
      <TD STYLE="padding-top: 0.25pt; padding-right: 0.25pt; padding-left: 0.25pt">&nbsp;</TD>
      <TD STYLE="padding-top: 0.25pt; padding-right: 0.25pt; padding-left: 0.25pt">&nbsp;</TD>
      <TD STYLE="padding-top: 0.25pt; padding-right: 0.25pt; padding-left: 0.25pt">&nbsp;</TD>
      <TD STYLE="padding-top: 0.25pt; padding-right: 0.25pt; padding-left: 0.25pt; text-align: center">&nbsp;</TD></TR>
    <TR STYLE="vertical-align: top">
      <TD STYLE="border-bottom: black 1.5pt solid; padding-top: 0.25pt; padding-right: 0.25pt; padding-left: 0.25pt">/s/ Lior Amit&nbsp;</TD>
      <TD STYLE="padding-top: 0.25pt; padding-right: 0.25pt; padding-left: 0.25pt">&nbsp;</TD>
      <TD STYLE="padding-top: 0.25pt; padding-right: 0.25pt; padding-left: 0.25pt"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">Director</FONT></TD>
      <TD STYLE="padding-top: 0.25pt; padding-right: 0.25pt; padding-left: 0.25pt">&nbsp;</TD>
      <TD STYLE="padding-top: 0.25pt; padding-right: 0.25pt; padding-left: 0.25pt; text-align: center"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">March 5, 2025</FONT></TD></TR>
    <TR STYLE="vertical-align: top">
      <TD STYLE="padding-top: 0.25pt; padding-right: 0.25pt; padding-left: 0.25pt"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">Lior Amit&nbsp;</FONT></TD>
      <TD STYLE="padding-top: 0.25pt; padding-right: 0.25pt; padding-left: 0.25pt">&nbsp;</TD>
      <TD STYLE="padding-top: 0.25pt; padding-right: 0.25pt; padding-left: 0.25pt">&nbsp;</TD>
      <TD STYLE="padding-top: 0.25pt; padding-right: 0.25pt; padding-left: 0.25pt">&nbsp;</TD>
      <TD STYLE="padding-top: 0.25pt; padding-right: 0.25pt; padding-left: 0.25pt; text-align: center">&nbsp;</TD></TR>
    <TR STYLE="vertical-align: top">
      <TD STYLE="padding-top: 0.25pt; padding-right: 0.25pt; padding-left: 0.25pt">&nbsp;</TD>
      <TD STYLE="padding-top: 0.25pt; padding-right: 0.25pt; padding-left: 0.25pt">&nbsp;</TD>
      <TD STYLE="padding-top: 0.25pt; padding-right: 0.25pt; padding-left: 0.25pt">&nbsp;</TD>
      <TD STYLE="padding-top: 0.25pt; padding-right: 0.25pt; padding-left: 0.25pt">&nbsp;</TD>
      <TD STYLE="padding-top: 0.25pt; padding-right: 0.25pt; padding-left: 0.25pt; text-align: center">&nbsp;</TD></TR>
    <TR STYLE="vertical-align: top">
      <TD STYLE="border-bottom: black 1.5pt solid; padding-top: 0.25pt; padding-right: 0.25pt; padding-left: 0.25pt">/s/ Limor Rozen</TD>
      <TD STYLE="padding-top: 0.25pt; padding-right: 0.25pt; padding-left: 0.25pt">&nbsp;</TD>
      <TD STYLE="padding-top: 0.25pt; padding-right: 0.25pt; padding-left: 0.25pt"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">Director</FONT></TD>
      <TD STYLE="padding-top: 0.25pt; padding-right: 0.25pt; padding-left: 0.25pt">&nbsp;</TD>
      <TD STYLE="padding-top: 0.25pt; padding-right: 0.25pt; padding-left: 0.25pt; text-align: center"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">March 5, 2025</FONT></TD></TR>
    <TR STYLE="vertical-align: top">
      <TD STYLE="padding-top: 0.25pt; padding-right: 0.25pt; padding-left: 0.25pt"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">Limor Rozen</FONT></TD>
      <TD STYLE="padding-top: 0.25pt; padding-right: 0.25pt; padding-left: 0.25pt">&nbsp;</TD>
      <TD STYLE="padding-top: 0.25pt; padding-right: 0.25pt; padding-left: 0.25pt">&nbsp;</TD>
      <TD STYLE="padding-top: 0.25pt; padding-right: 0.25pt; padding-left: 0.25pt">&nbsp;</TD>
      <TD STYLE="padding-top: 0.25pt; padding-right: 0.25pt; padding-left: 0.25pt; text-align: center">&nbsp;</TD></TR>
    </TABLE>
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"></P>
  
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  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B>&nbsp;</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>SIGNATURE OF AUTHORIZED REPRESENTATIVE IN THE
  UNITED STATES</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>&nbsp;</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">Pursuant to the Securities Act, the undersigned,
  Puglisi &amp; Associates, the duly authorized representative in the United States of Inspira Technologies Oxy B.H.N. Ltd., has signed
  this Registration Statement on Form S-8 on March 5, 2025.</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&nbsp;</P>
  
  <TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
    <TR STYLE="vertical-align: top">
      <TD STYLE="padding-top: 0.25pt; padding-right: 0.25pt; padding-left: 0.25pt">&nbsp;</TD>
      <TD COLSPAN="2" STYLE="padding-top: 0.25pt; padding-right: 0.25pt; padding-left: 0.25pt"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">Puglisi &amp; Associates</FONT></TD></TR>
    <TR STYLE="vertical-align: top">
      <TD STYLE="padding-top: 0.25pt; padding-right: 0.25pt; padding-left: 0.25pt">&nbsp;</TD>
      <TD COLSPAN="2" STYLE="padding-top: 0.25pt; padding-right: 0.25pt; padding-left: 0.25pt">&nbsp;</TD></TR>
    <TR STYLE="vertical-align: top">
      <TD STYLE="padding-top: 0.25pt; padding-right: 0.25pt; padding-left: 0.25pt">&nbsp;</TD>
      <TD COLSPAN="2" STYLE="padding-top: 0.25pt; padding-right: 0.25pt; padding-left: 0.25pt"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">Authorized U.S. Representative </FONT></TD></TR>
    <TR STYLE="vertical-align: top">
      <TD STYLE="padding-top: 0.25pt; padding-right: 0.25pt; padding-left: 0.25pt">&nbsp;</TD>
      <TD COLSPAN="2" STYLE="padding-top: 0.25pt; padding-right: 0.25pt; padding-left: 0.25pt">&nbsp;</TD></TR>
    <TR STYLE="vertical-align: top">
      <TD STYLE="padding-top: 0.25pt; padding-right: 0.25pt; padding-left: 0.25pt">&nbsp;</TD>
      <TD COLSPAN="2" STYLE="border-bottom: black 1.5pt solid; padding: 0.25pt 0.25pt 0.75pt">/s/ Donald J. Puglisi</TD></TR>
    <TR STYLE="vertical-align: top">
      <TD STYLE="width: 60%; padding-top: 0.25pt; padding-right: 0.25pt; padding-left: 0.25pt">&nbsp;</TD>
      <TD STYLE="width: 5%; padding-top: 0.25pt; padding-right: 0.25pt; padding-left: 0.25pt"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">Name:&nbsp; </FONT></TD>
      <TD STYLE="width: 35%; padding-top: 0.25pt; padding-right: 0.25pt; padding-left: 0.25pt"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">Donald J. Puglisi</FONT></TD></TR>
    <TR STYLE="vertical-align: top">
      <TD STYLE="padding-top: 0.25pt; padding-right: 0.25pt; padding-left: 0.25pt">&nbsp;</TD>
      <TD STYLE="padding-top: 0.25pt; padding-right: 0.25pt; padding-left: 0.25pt"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">Title:</FONT></TD>
      <TD STYLE="padding-top: 0.25pt; padding-right: 0.25pt; padding-left: 0.25pt"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">Managing Director</FONT></TD></TR>
    </TABLE>
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  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">II-4</P>
  
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metadata_documents: [{"type": "S-8", "sequence": "1", "filename": "ea0233153-s8_inspira.htm", "description": "REGISTRATION STATEMENT", "secsgml_size_bytes": 59227}]
metadata_filer: {"company-data": {"conformed-name": "Inspira Technologies OXY B.H.N. Ltd", "cik": "0001837493", "assigned-sic": "3841", "organization-name": "08 Industrial Applications and Services", "irs-number": "000000000", "state-of-incorporation": "L3", "fiscal-year-end": "1231"}, "filing-values": {"form-type": "S-8", "act": "33", "file-number": "333-285565", "film-number": "25710916"}, "business-address": {"street1": "HATIDHAR 2", "street2": "11TH FLOOR", "city": "RA'ANANA", "state": "L3", "zip": "4366504", "phone": "972-9-9664488"}, "mail-address": {"street1": "HATIDHAR 2", "street2": "11TH FLOOR", "city": "RA'ANANA", "state": "L3", "zip": "4366504"}}
text: As filed with the Securities and Exchange Commission
  on March 5, 2025
  Registration No. 333 -
  UNITED STATES
  SECURITIES AND EXCHANGE COMMISSION
  WASHINGTON, D.C. 20549
  FORM S-8
  REGISTRATION STATEMENT
  UNDER
  THE SECURITIES ACT OF 1933
  INSPIRA TECHNOLOGIES OXY B.H.N. LTD.
  (Exact name of registrant as specified in its charter)
  State of Israel
  Not applicable
  (State or other jurisdiction of
  incorporation or organization)
  (I.R.S. Employer
  Identification No.)
  2 Ha-Tidhar St., Ra'anana, 4366504 Israel
  (Address of Principal Executive Offices)
  Inspira Technologies OXY B.H.N. LTD.
  Amended and Restated 2019 Equity Incentive Plan
  (Full title of the plan)
  Puglisi & Associates
  850 Library Ave., Suite 204, Newark, DE 19711
  Tel: (302) 738-6680
  (Name, Address and Telephone Number of Agent for
  Service)
  COPIES TO:
  Oded Har-Even, Esq.
  Ron Ben-Bassat, Esq.
  Sullivan & Worcester LLP
  1251 Avenue of the Americas
  New York, NY 10020
  Tel: (212)-660-3000
  Adv. Reut Alfiah
  Adv. Gal Cohen
  Sullivan & Worcester Tel-Aviv (Har-Even &
      Co.)
  28 HaArba'a St. HaArba'a Towers
  North Tower, 35th floor
  Tel-Aviv, Israel 6473925
  Tel: +972 74-758-0480
  Indicate by check mark whether the registrant is a large accelerated
  filer, an accelerated filer, a non-accelerated filer, a smaller reporting company or an emerging growth company. See definitions of "large
  accelerated filer," "accelerated filer," "smaller reporting company" and "emerging growth company"
  in Rule 12b-2 of the Exchange Act.
  Large accelerated filer ☐
  Accelerated filer ☐
  Non-accelerated filer ☒
  Smaller reporting company ☐
  Emerging growth company ☒
  If an emerging growth company, indicate by check mark if the registrant
  has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant
  to Section 7(a)(2)(B) of the Securities Act. ☐
  EXPLANATORY NOTE
  On August 5, 2021, Inspira Technologies Oxy B.H.N.
  Ltd., or the Registrant or the Company, filed a Registration Statement on Form S-8 (File No. 333-259057), or the Original Registration
  Statement, with the Securities and Exchange Commission, or the SEC, to register an aggregate of 4,180,898 ordinary shares, no par value
  per share, of the Company, or the Ordinary Shares, that may be issued pursuant to the Company's 2019 Equity Incentive Plan, or the
  2019 Plan. On March 15, 2024, the Company filed an additional Registration Statement on Form S-8 (File No. 333-277980) with the SEC to
  register an additional 2,997,671 Ordinary Shares that may be issued pursuant to the 2019 Plan.
  The 2019 Plan was originally adopted by the
  board of directors of the Company in November 2019, amended in September 2021, and further amended and restated in March 2025, or
  the Amended and Restated 2019 Plan.
  The Company is filing this Registration Statement
  on Form S-8, or this Registration Statement, to register an additional 3,000,000 Ordinary Shares reserved for issuance in connection with
  securities awards which may hereafter be granted under the Amended and Restated 2019 Plan.
  Pursuant to General Instruction E to Form S-8,
  the contents of the Original Registration Statement are incorporated herein by reference, except for Items 3 and 8 of Part II of the Original
  Registration Statement, which are being updated by this Registration Statement.
  PART I
  INFORMATION REQUIRED IN THE SECTION 10(a) PROSPECTUS
  The information specified in Item 1 and Item 2
  of Part I of Form S-8 is omitted from this Registration Statement. The documents containing the information specified in Part I of Form
  S-8 will be delivered to the participants in the Plan covered by this Registration Statement as specified by Rule 428(b)(1) under
  the Securities Act of 1933, as amended, or the Securities Act.
  1
  PART II
  ITEM 3.
  INCORPORATION OF DOCUMENTS BY REFERENCE
  The following documents filed by the Company with
  the SEC are incorporated by reference into this Registration Statement:
  (a) Our Annual Report on
  Form 20-F
  for the
  fiscal year ended December 31, 2023, filed with the SEC on March 25, 2024;
  (b) Our Reports on Form 6-K furnished on
  March
  25, 2024
  (with respect to the first paragraph, the section titled "Full Year 2023 Financial Results" and the section
  titled "Forward-Looking Statements" in the press release attached as Exhibit 99.1),
  April
  1, 2024
  ,
  April 3, 2024
  (with
  respect to the first two paragraphs and the section titled "Forward-Looking Statements" in the press release attached
  as Exhibit 99.1),
  April 9, 2024
  ,
  April
  10, 2024
  (with respect to the first five paragraphs and the section titled "Forward-Looking Statements" in the press
  release attached as Exhibit 99.1),
  April
  17, 2024
  (with respect to the first four paragraphs and the section titled "Forward-Looking Statements" in the press
  release attached as Exhibit 99.1),
  April
  25, 2024
  (with respect to the first three paragraphs and the section titled "Forward-Looking Statements" in the press
  release attached as Exhibit 99.1),
  May
  2, 2024
  ,
  May 28, 2024
  (with
  respect to the first paragraph and the section titled "Forward-Looking Statements" in the press release attached as Exhibit
  99.1),
  June 13, 2024
  (with
  respect to the first, second and fourth paragraphs and the section titled "Forward-Looking Statements" in the press release
  attached as Exhibit 99.1),
  June
  17, 2024
  ,
  June 18,
  2024
  ,
  June 20, 2024
  ,
  July
  11, 2024
  (with respect to the first paragraph and the section titled "Forward-Looking Statements" in the press release
  attached as Exhibit 99.1),
  July
  30, 2024
  (with respect to the first, third, fourth, fifth and sixth paragraphs and the section titled "Forward-Looking
  Statements" in the press release attached as Exhibit 99.1),
  August
  13, 2024
  (with respect to the first two paragraphs and the section titled "Forward-Looking Statements" in the press
  release attached as Exhibit 99.1),
  August
  15, 2024
  ,
  August 22, 2024
  (with
  respect to the first two paragraphs and the section titled "Forward-Looking Statements" in the press release attached as Exhibit
  99.1),
  August 28, 2024
  (with
  respect to the first paragraph and the sections titled "Future Plans," "Inspira™ business overview," and
  "Forward-Looking Statements" in the press release attached as Exhibit 99.1),
  September
  13, 2024
  (with respect to the first two paragraphs and the section titled "Forward-Looking Statements" in the press release
  attached as Exhibit 99.1),
  October
  9, 2024
  (with respect to the first three paragraphs and the section titled "Forward-Looking Statements"),
  October
  24, 2024
  (with respect to the first three paragraphs and the section titled "Forward-Looking Statements" in the press
  release attached as Exhibit 99.1),
  November
  12, 2024
  ,
  November 25, 2024
  ,
  December 4, 2024
  (with respect
  to the first two paragraphs and the section titled "Forward-Looking Statements" in the press release attached as Exhibit 99.1),
  December 10, 2024
  (with respect
  to the first three paragraphs and the section titled "Forward-Looking Statements" in the press release attached as Exhibit
  99.1),
  December 16, 2024
  (with
  respect to the first three paragraphs and the section titled "Forward-Looking Statements" in the press release attached as
  Exhibit 99.1),
  December 27, 2024
  ,
  December 30, 2024
  ,
  January
  7, 2025
  (with respect to the first four paragraphs and the section titled "Forward-Looking Statements" in the press release
  attached as Exhibit 99.1), and
  January
  10, 2025
  (with respect to the first three paragraphs, fifth paragraph and the section titled "Forward-Looking Statements"
  in the press release attached as Exhibit 99.1),
  January
  14, 2025
  (with respect to the first four paragraphs and the section titled "Forward-Looking Statements" in the press release
  attached as Exhibit 99.1),
  January
  17, 2025
  ,
  January 21, 2025
  ,
  January 27, 2025
  (with respect
  to the first, second, third and fifth paragraphs and the section titled "Forward-Looking Statements" in the press release
  attached as Exhibit 99.1),
  February 5, 2025
  (with respect to the first, second, third and fifth paragraphs and the section titled "Forward-Looking
  Statements"),
  February 11, 2025
  (with respect to the first, second, fourth and fifth paragraphs and the section titled "Forward-Looking
  Statements") and
  March 4, 2025
  (with respect to the first, second, fourth and fifth paragraphs and the section titled "Forward-Looking
  Statements"); and
  (c) The description of our securities contained
  in
  Exhibit 2.1
  to our Annual
  Report on
  Form 20-F
  for the fiscal year ended December 31, 2023, filed with the SEC on March 25, 2024, including any amendments or reports
  filed for the purpose of updating such description.
  II-
  1
  In addition to the foregoing, all documents subsequently
  filed by the Registrant pursuant to Sections 13(a), 13(c), 14 and 15(d) of the Exchange Act and all reports on Form 6-K subsequently filed
  by the Registrant which state that they are incorporated by reference herein, prior to the filing of a post-effective amendment which
  indicates that all securities offered hereunder have been sold or which deregisters all securities then remaining unsold, shall be deemed
  to be incorporated by reference herein and to be part hereof from the date of filing of such documents and reports.
  Any statement contained in a document incorporated
  or deemed to be incorporated by reference herein shall be deemed to be modified or superseded for purposes of this Registration Statement
  to the extent that a statement herein, or in any subsequently filed document which also is or is deemed to be incorporated by reference,
  modifies or supersedes such statement. Any statement so modified or superseded shall not be deemed, except as so modified or superseded,
  to constitute a part of this Registration Statement.
  Item 8.
  Exhibits.
  4.1
  Amended and Restated Articles of Association of Inspira Technologies Oxy B.H.N. Ltd. (incorporated by reference to Exhibit 99.1 to the Company's Report on Form 6-K (File No. 001-40303) filed on December 20, 2021).
  5.1*
  Opinion of Sullivan & Worcester Tel Aviv (Har-Even & Co.)
  23.1*
  Consent of Ziv Haft, member firm of BDO, independent registered public accounting firm.
  23.2*
  Consent of Sullivan & Worcester Tel Aviv (Har-Even & Co.) (included in the opinion filed as Exhibit 5.1 to this Registration Statement)
  24.1*
  Power of Attorney (included on signature page)
  99.1*
  Amended
      and Restated Inspira Technologies Oxy B.H.N. Ltd. 2019 Equity Incentive Plan
  107*
  Filing Fee Table.
  *
  Filed herewith.
  II-
  2
  SIGNATURES
  Pursuant to the requirements of the Securities
  Act, the registrant certifies that it has reasonable grounds to believe that it meets all of the requirements for filing on Form S-8 and
  has duly caused this Registration Statement on Form S-8 to be signed on its behalf by the undersigned, thereunto duly authorized, in Ra'anana,
  Israel, on March 5, 2025.
  INSPIRA TECHNOLOGIES OXY B.H.N. LTD.
  By:
  /s/ Dagi Ben-Noon
  Name:
  Dagi Ben-Noon
  Title:
  Chief Executive Officer
  POWER OF ATTORNEY AND SIGNATURES
  We, the undersigned officers and directors of Inspira
  Technologies Oxy B.H.N. Ltd., hereby severally constitute and appoint Dagi Ben-Noon and Joe Hayon, and each of them individually, our
  true and lawful attorney to sign for us and in our names in the capacities indicated below any and all amendments or supplements, including
  any post-effective amendments, to this Registration Statement on Form S-8 and to file the same, with exhibits thereto and other documents
  in connection therewith, with the Securities and Exchange Commission, granting unto said attorney full power and authority to do and perform
  each and every act and thing requisite or necessary to be done in and about the premises, as fully to all intents and purposes as he or
  she might or could do in person, hereby ratifying and confirming our signatures to said amendments to this Registration Statement signed
  by our said attorney and all else that said attorney may lawfully do and cause to be done by virtue hereof.
  Pursuant to the requirements of the Securities
  Act, this Registration Statement on Form S-8 has been signed below by the following persons in the capacities and on the dates indicated.
  Signature
  Title
  Date
  /s/ Dagi Ben-Noon
  Chief Executive Officer and Director
  March 5, 2025
  Dagi Ben-Noon
  (Principal Executive Officer)
  /s/ Yafit Tehila
  Chief Financial Officer
  March 5, 2025
  Yafit Tehila
  (Principal Financial Officer and Principal Accounting Officer)
  /s/ Joe Hayon
  President and Director
  March 5, 2025
  Joe Hayon
  /s/ Tal Parnes
  Chairman of the Board of Directors
  March 5, 2025
  Tal Parnes
  /s/ Lior Amit
  Director
  March 5, 2025
  Lior Amit
  /s/ Limor Rozen
  Director
  March 5, 2025
  Limor Rozen
  II-
  3
  SIGNATURE OF AUTHORIZED REPRESENTATIVE IN THE
  UNITED STATES
  Pursuant to the Securities Act, the undersigned,
  Puglisi & Associates, the duly authorized representative in the United States of Inspira Technologies Oxy B.H.N. Ltd., has signed
  this Registration Statement on Form S-8 on March 5, 2025.
  Puglisi & Associates
  Authorized U.S. Representative
  /s/ Donald J. Puglisi
  Name:
  Donald J. Puglisi
  Title:
  Managing Director
  II-4