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  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>As filed with the Securities and Exchange
  Commission on September 9, 2020</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: right"><B>Registration No. 333-&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</B></P>
  
  <!-- Field: Rule-Page --><DIV STYLE="width: 100%"><DIV STYLE="font-size: 1pt; border-top: Black 2pt solid; border-bottom: Black 1pt solid">&nbsp;</DIV></DIV><!-- Field: /Rule-Page -->
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: right"></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>UNITED STATES</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>SECURITIES AND EXCHANGE COMMISSION</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>Washington, D.C. 20549</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>FORM S-8</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>REGISTRATION STATEMENT UNDER THE SECURITIES
  ACT OF 1933</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B><U>PLURISTEM THERAPEUTICS INC.</U></B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">(Exact name of registrant as specified in
  its charter)</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
  
  <TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
  <TR STYLE="vertical-align: bottom">
      <TD STYLE="border-bottom: Black 1.5pt solid; width: 49%; font-size: 10pt; text-align: center"><FONT STYLE="font-size: 10pt"><B>Nevada</B></FONT></TD>
      <TD STYLE="padding-bottom: 1.5pt; width: 2%">&nbsp;</TD>
      <TD STYLE="border-bottom: Black 1.5pt solid; width: 49%; font-size: 10pt; text-align: center"><FONT STYLE="font-size: 10pt"><B>98-0351734</B></FONT></TD></TR>
  <TR>
      <TD STYLE="vertical-align: bottom; font-size: 10pt; text-align: center"><FONT STYLE="font-size: 10pt">(State or other jurisdiction of <BR>
  incorporation or organization)</FONT></TD>
      <TD>&nbsp;</TD>
      <TD STYLE="vertical-align: top; font-size: 10pt; text-align: center"><FONT STYLE="font-size: 10pt">(I.R.S. Employer <BR>
  Identification No.)</FONT></TD></TR>
  </TABLE>
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
  
  <TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
  <TR STYLE="vertical-align: bottom">
      <TD STYLE="border-bottom: Black 1.5pt solid; width: 49%; text-align: center"><FONT STYLE="font-size: 10pt"><B>MATAM Advanced Technology Park,<BR>
  Building No. 5,
      Haifa, Israel</B></FONT></TD>
      <TD STYLE="padding-bottom: 1.5pt; width: 2%">&nbsp;</TD>
      <TD STYLE="border-bottom: Black 1.5pt solid; width: 49%; text-align: center"><FONT STYLE="font-size: 10pt"><B>3508409</B></FONT></TD></TR>
  <TR STYLE="vertical-align: bottom">
      <TD STYLE="text-align: center"><FONT STYLE="font-size: 10pt">(Address of Principal Executive Offices)</FONT></TD>
      <TD>&nbsp;</TD>
      <TD STYLE="text-align: center"><FONT STYLE="font-size: 10pt">(Zip Code)</FONT></TD></TR>
  </TABLE>
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>&nbsp;&nbsp;&nbsp;</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B><U>Pluristem Therapeutics Inc. 2016 Equity
  Compensation Plan</U></B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">(Full title of the plan)</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>Nevada Agency and Transfer Company</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>50 West Liberty Street, Suite 880</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B><U>Reno, NV 89501</U></B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">(Name and address of agent for service)</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B><U>(775) 322-0626</U></B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">(Telephone number, including area code,
  of agent for service)</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">Copy to:</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>Oded Har-Even</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>Howard E. Berkenblit</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>Ron Ben-Bassat</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>Sullivan &amp; Worcester LLP</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>One Post Office Square</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>Boston, Massachusetts 02110</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>Telephone: (617) 338-2800</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>Fax: (617) 338-2880</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Indicate by check mark whether the registrant is a large accelerated
  filer, an accelerated non-accelerated filer, smaller reporting company, or an emerging growth company. See definitions of &ldquo;large
  accelerated filer,&rdquo; &ldquo;accelerated filer,&rdquo; &ldquo;smaller reporting company,&rdquo; and &ldquo;emerging growth
  company&rdquo; in Rule 12b-2 of the Exchange Act.</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
  
  <TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
  <TR>
      <TD STYLE="width: 67%"><FONT STYLE="font-size: 10pt">Large accelerated filer&nbsp; &#9744;</FONT></TD>
      <TD STYLE="width: 33%"><FONT STYLE="font-size: 10pt">Accelerated filer&nbsp; <FONT STYLE="font-family: Times New Roman, Times, Serif">&#9744;</FONT></FONT></TD></TR>
  <TR>
      <TD><FONT STYLE="font-size: 10pt">Non-accelerated filer&nbsp;&nbsp;<FONT STYLE="font-family: Times New Roman, Times, Serif">&#9746;</FONT></FONT></TD>
      <TD><FONT STYLE="font-size: 10pt">Smaller reporting company&nbsp; &#9746;</FONT></TD></TR>
  <TR>
      <TD>&nbsp;</TD>
      <TD><FONT STYLE="font-size: 10pt">Emerging growth company&nbsp; &#9744;</FONT></TD></TR>
  </TABLE>
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">If an emerging growth company, indicate by check mark if the
  registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards
  provided pursuant to Section 13(a) of the Exchange Act.&nbsp; &#9744;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
  
  
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  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>&nbsp;</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>CALCULATION OF REGISTRATION FEE</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
  
  <TABLE CELLPADDING="0" CELLSPACING="0" STYLE="border-collapse: collapse; width: 100%; font: 10pt Times New Roman, Times, Serif">
  <TR STYLE="vertical-align: bottom">
      <TD STYLE="white-space: nowrap; font: 10pt Times New Roman, Times, Serif; text-align: center; border-bottom: Black 1.5pt solid"><P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: left"><B>Title of securities to be
                                                                                                                 registered</B></P></TD><TD STYLE="white-space: nowrap; font: 10pt Times New Roman, Times, Serif; padding-bottom: 1.5pt">&nbsp;</TD>
      <TD COLSPAN="2" STYLE="white-space: nowrap; font: 10pt Times New Roman, Times, Serif; text-align: center; border-bottom: Black 1.5pt solid"><P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>Amount<BR>
  to be<BR>
  registered&nbsp;(1)</B></P></TD><TD STYLE="white-space: nowrap; padding-bottom: 1.5pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</TD><TD STYLE="white-space: nowrap; font: 10pt Times New Roman, Times, Serif; padding-bottom: 1.5pt">&nbsp;</TD>
      <TD COLSPAN="2" STYLE="white-space: nowrap; font: 10pt Times New Roman, Times, Serif; text-align: center; border-bottom: Black 1.5pt solid"><P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>Proposed<BR>
  maximum<BR>
  offering<BR>
  price&nbsp;per<BR>
  share&nbsp;(2)</B></P></TD><TD STYLE="white-space: nowrap; padding-bottom: 1.5pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</TD><TD STYLE="white-space: nowrap; font: 10pt Times New Roman, Times, Serif; padding-bottom: 1.5pt">&nbsp;</TD>
      <TD COLSPAN="2" STYLE="white-space: nowrap; font: 10pt Times New Roman, Times, Serif; text-align: center; border-bottom: Black 1.5pt solid"><P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>Proposed<BR>
  maximum<BR>
  aggregate<BR>
  offering<BR>
  price&nbsp;(2)</B></P></TD><TD STYLE="white-space: nowrap; padding-bottom: 1.5pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</TD><TD STYLE="white-space: nowrap; font: 10pt Times New Roman, Times, Serif; padding-bottom: 1.5pt">&nbsp;</TD>
      <TD COLSPAN="2" STYLE="white-space: nowrap; font: 10pt Times New Roman, Times, Serif; text-align: center; border-bottom: Black 1.5pt solid"><P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>Amount
  of<BR>
  registration fee</B></P></TD><TD STYLE="white-space: nowrap; padding-bottom: 1.5pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</TD></TR>
  <TR STYLE="vertical-align: bottom; background-color: rgb(204,238,255)">
      <TD STYLE="width: 52%; font-size: 10pt">Common Stock, $0.00001 par value (3)</TD><TD STYLE="width: 1%; font-size: 10pt">&nbsp;</TD>
      <TD STYLE="width: 1%; font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="width: 9%; font-size: 10pt; text-align: right">150,000</TD><TD STYLE="width: 1%; font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="width: 1%; font-size: 10pt">&nbsp;</TD>
      <TD STYLE="width: 1%; font-size: 10pt; text-align: left">$</TD><TD STYLE="width: 9%; font-size: 10pt; text-align: right">9.72</TD><TD STYLE="width: 1%; font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="width: 1%; font-size: 10pt">&nbsp;</TD>
      <TD STYLE="width: 1%; font-size: 10pt; text-align: left">$</TD><TD STYLE="width: 9%; font-size: 10pt; text-align: right">1,458,000</TD><TD STYLE="width: 1%; font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="width: 1%; font-size: 10pt">&nbsp;</TD>
      <TD STYLE="width: 1%; font-size: 10pt; text-align: left">$</TD><TD STYLE="width: 9%; font-size: 10pt; text-align: right">189.25</TD><TD STYLE="width: 1%; font-size: 10pt; text-align: left">&nbsp;</TD></TR>
  </TABLE>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
  
  <TABLE CELLPADDING="0" CELLSPACING="0" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; width: 100%"><TR STYLE="vertical-align: top; text-align: justify">
  <TD STYLE="width: 0"></TD><TD STYLE="width: 0.25in; text-align: left">(1)</TD><TD STYLE="text-align: left">In accordance with Rule 416(a) under the Securities Act
  of 1933, as amended, or the Securities Act, this registration statement shall be deemed to cover an indeterminate number of additional
  securities that may from time to time be offered or issued to prevent dilution resulting from stock splits, stock dividends or
  similar transactions.</TD>
  </TR></TABLE>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
  
  <TABLE CELLPADDING="0" CELLSPACING="0" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; width: 100%"><TR STYLE="vertical-align: top; text-align: justify">
  <TD STYLE="width: 0"></TD><TD STYLE="width: 0.25in; text-align: left">(2)</TD><TD STYLE="text-align: left">Estimated in accordance with Rules 457(h)(1) and 457(c)
  promulgated under the Securities Act, solely for the purpose of calculating the registration fee, based on $9.72 the average of
  the high and low sales prices of the Common Stock on the Nasdaq Capital Market on September 4, 2020.</TD>
  </TR></TABLE>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
  
  <TABLE CELLPADDING="0" CELLSPACING="0" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; width: 100%"><TR STYLE="vertical-align: top; text-align: justify">
  <TD STYLE="width: 0"></TD><TD STYLE="width: 0.25in; text-align: left">(3)</TD><TD STYLE="text-align: left">Represents shares of Common Stock issuable upon stock options
  or other awards to be granted pursuant to the Pluristem Therapeutics Inc. 2016 Equity Compensation Plan, or the 2016 Plan.</TD>
  </TR></TABLE>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"></P>
  
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  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><FONT STYLE="background-color: white"><B>EXPLANATORY
  NOTE</B></FONT></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in"><FONT STYLE="background-color: white">On
  June 29, 2016, the Company filed a Registration Statement on Form S-8 (File No. 333-212299), or the Original Registration Statement,
  with the Securities and Exchange Commission, or the Commission, t</FONT>o register an aggregate of 2,614,197 shares of Common Stock
  of the Company that may be issued pursuant to the 2016 Plan.</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">On May 8, 2017, the Company filed <FONT STYLE="background-color: white">a
  Registration Statement on Form S-8 (File No. 333-217770), or the Second Registration Statement<B>,</B></FONT> with the Commission
  to register an additional 2,527,000 shares of Common Stock of the Company that may be issued pursuant to the 2016 Plan.</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">On February 6, 2018, the Company filed a
  Registration Statement on Form S-8 (File No. 333-222888), or the Third Registration Statement, with the Commission to register
  an additional 3,450,000 shares of Common Stock of the Company that may be issued pursuant to the 2016 Plan.</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">On February 6, 2019, the Company filed a
  Registration Statement on Form S-8 (File No. 333-229535), or the Fourth Registration Statement, with the Commission to register
  an additional 3,450,000 shares of Common Stock of the Company that may be issued pursuant to the 2016 Plan.</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">Pursuant to the 2016 Plan, the number of
  shares of Common Stock of the Company made available under the 2016 Plan shall not exceed 2.75% of the number of shares of Common
  Stock of the Company issued and outstanding on a fully diluted basis on the immediately preceding December 31.</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in"><FONT STYLE="background-color: white">The
  Company is filing this Registration Statement on Form S-8 to register an additional 150,000 shares of Common Stock of the Company,&nbsp;which
  may be issued in connection with securities awards which may hereafter&nbsp; be granted under the 2016 Plan.</FONT></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">Pursuant to General Instruction E to Form
  S-8, the contents of the Original Registration Statement, the Second Registration Statement, the Third Registration Statement and
  the Fourth Registration Statement, or collectively, the Prior Registration Statement, are incorporated herein by reference, except
  for Item 3 and Item 8 of Part II of the Prior Registration Statements, which are being updated by this registration statement.</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
  
  
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  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>PART II</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>INFORMATION REQUIRED IN THE REGISTRATION
  STATEMENT</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B>Item 3.&nbsp;&nbsp;Incorporation of Documents by Reference.</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">The following additional documents, which
  have been filed by the&nbsp;Company with the Commission under the Securities Exchange Act of 1934, as amended, or the Exchange
  Act, are incorporated by reference in and made a part of this registration statement, as of their respective dates:</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">(a) Our Annual Report on <A HREF="http://www.sec.gov/Archives/edgar/data/1158780/000121390019017859/f10k2019_pluristemtherap.htm">Form 10-K</A> for the
  year ended June 30, 2019 filed with the SEC on September 12, 2019;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">(b) Our Quarterly Reports on Form 10-Q for
  the quarters ended <A HREF="http://www.sec.gov/Archives/edgar/data/1158780/000121390019022345/f10q0919_pluristemtherape.htm">September 30, 2019</A>, <A HREF="http://www.sec.gov/Archives/edgar/data/1158780/000121390020002786/f10q1219_pluristemtherap.htm">December 31, 2019</A> and <A HREF="http://www.sec.gov/Archives/edgar/data/1158780/000121390020011667/f10q0320_pluristem.htm">March 31, 2020</A>, as filed with the SEC on November 7, 2019, February
  6, 2020 and May 11, 2020, respectively;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">(c) Our Current Reports on Form 8-K filed
  with the SEC on <A HREF="http://www.sec.gov/Archives/edgar/data/1158780/000121390019011923/f8k063019_pluristemtherape.htm">July 2, 2019</A>, <A HREF="http://www.sec.gov/Archives/edgar/data/1158780/000121390019013606/f8k072319_pluristemtherape.htm">July 25, 2019</A>, <A HREF="http://www.sec.gov/Archives/edgar/data/1158780/000121390019015238/f8k080819_pluristemtherape.htm">August 12, 2019</A>, <A HREF="http://www.sec.gov/Archives/edgar/data/1158780/000121390020005231/ea119228-8k_pluristem.htm">March 3, 2020</A>, <A HREF="http://www.sec.gov/Archives/edgar/data/1158780/000121390020006072/ea119556-8k_pluristemtherape.htm">March 12, 2020</A>, <A HREF="http://www.sec.gov/Archives/edgar/data/1158780/000121390020007499/ea120036-8k_pluristem.htm">March 26, 2020</A>, <A HREF="http://www.sec.gov/Archives/edgar/data/1158780/000121390020007923/ea120227-8k_pluristemthera.htm">March 30, 2020</A>, <A HREF="http://www.sec.gov/Archives/edgar/data/1158780/000121390020008735/ea120496-8k_pluristem.htm">April 7, 2020</A>, <A HREF="http://www.sec.gov/Archives/edgar/data/1158780/000121390020009033/ea120617-8k_pluristemtherap.htm">April 13, 2020</A>, <A HREF="http://www.sec.gov/Archives/edgar/data/1158780/000121390020010010/ea121023-8k_pluristem.htm">April 24, 2020</A>, <A HREF="http://www.sec.gov/Archives/edgar/data/1158780/000121390020010560/ea121226-8k_pluristemther.htm">April 30, 2020</A>, <A HREF="http://www.sec.gov/Archives/edgar/data/1158780/000121390020011021/ea121427-8k_pluristemtherap.htm">May 5, 2020</A>, <A HREF="http://www.sec.gov/Archives/edgar/data/1158780/000121390020011347/ea121553-8k_pluristemthera.htm">May 8, 2020</A>, <A HREF="http://www.sec.gov/Archives/edgar/data/1158780/000121390020012115/ea121819-8k_pluristem.htm">May 14, 2020</A>, <A HREF="http://www.sec.gov/Archives/edgar/data/1158780/000121390020014660/ea122928-8k_pluristemtherap.htm">June 11, 2020</A>, <A HREF="http://www.sec.gov/Archives/edgar/data/1158780/000121390020016446/ea123659-8k_pluristem.htm">July 1, 2020</A>, <A HREF="http://www.sec.gov/Archives/edgar/data/1158780/000121390020017683/ea124213-8k_pluristem.htm">July 16, 2020</A>, <A HREF="http://www.sec.gov/Archives/edgar/data/1158780/000121390020018046/ea124396-8k_pluristem.htm">July 21, 2020</A>, <A HREF="http://www.sec.gov/Archives/edgar/data/1158780/000121390020021021/ea125262-8k_pluristemtherap.htm">August 10, 2020</A> and <A HREF="http://www.sec.gov/Archives/edgar/data/1158780/000121390020023944/ea126100-8k_pluristem.htm">August 27, 2020</A>; and</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">(d) The description of the Company&rsquo;s
  Common Stock contained in the Registration Statement on <A HREF="http://www.sec.gov/Archives/edgar/data/1158780/000114420407066561/v096772_8ka.htm">Form 8-A</A> filed with the Commission on December 10, 2007, under the Exchange
  Act, including any amendment or report filed or to be filed for the purpose of updating such description.</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">In addition to the foregoing, all documents
  subsequently filed by the Company pursuant to Sections 13(a), 13(c), 14 and 15(d) of the Exchange Act subsequently filed by the
  Company prior to the filing of a post-effective amendment which indicates that all securities offered hereunder have been sold
  or which deregisters all securities then remaining unsold, shall be deemed to be incorporated by reference herein and to be part
  hereof from the date of filing of such documents and reports.</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">Any statement contained in a document incorporated
  or deemed to be incorporated by reference herein shall be deemed to be modified or superseded for purposes of this registration
  statement to the extent that a statement herein, or in any subsequently filed document which also is or is deemed to be incorporated
  by reference, modifies or supersedes such statement.&nbsp;&nbsp;Any statement so modified or superseded shall not be deemed, except
  as so modified or superseded, to constitute a part of this Registration Statement.</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B>Item 8.&nbsp;&nbsp;Exhibits.</B>&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
  
  <TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
  <TR STYLE="vertical-align: top">
      <TD STYLE="text-align: center; border-bottom: Black 1.5pt solid; width: 8%"><FONT STYLE="font-size: 10pt"><B>Exhibit No.</B></FONT></TD>
      <TD STYLE="padding-bottom: 1.5pt; width: 1%">&nbsp;</TD>
      <TD STYLE="text-align: center; border-bottom: Black 1.5pt solid; width: 91%; vertical-align: bottom"><FONT STYLE="font-size: 10pt"><B>Description</B></FONT></TD></TR>
  <TR STYLE="vertical-align: top; background-color: rgb(204,238,255)">
      <TD><FONT STYLE="font-size: 10pt">4.1</FONT></TD>
      <TD>&nbsp;</TD>
      <TD><A HREF="http://www.sec.gov/Archives/edgar/data/1158780/000121390020017673/ea124148ex4-1_pluristem.htm"><FONT STYLE="font-size: 10pt">Composite Copy of the Company&rsquo;s Articles of Incorporation as amended on July 2, 2020 (incorporated by reference to Exhibit 4.1 of our registration statement on Form S-3 filed on July 16, 2020). </FONT></A></TD></TR>
  <TR STYLE="vertical-align: top; background-color: White">
      <TD><FONT STYLE="font-size: 10pt">4.2</FONT></TD>
      <TD>&nbsp;</TD>
      <TD><A HREF="http://www.sec.gov/Archives/edgar/data/1158780/000117891317000962/exhibit_3-1.htm"><FONT STYLE="font-size: 10pt">Amended and Restated By-laws (incorporated by reference to Exhibit 3.1 of the Company&rsquo;s Current Report on Form 8-K filed with the SEC on March 29, 2017).</FONT></A></TD></TR>
  <TR STYLE="vertical-align: top; background-color: rgb(204,238,255)">
      <TD><FONT STYLE="font-size: 10pt">5.1*</FONT></TD>
      <TD>&nbsp;</TD>
      <TD><A HREF="ea126543ex5-1_pluristem.htm"><FONT STYLE="font-size: 10pt">Opinion of Sullivan &amp; Worcester LLP.</FONT></A></TD></TR>
  <TR STYLE="vertical-align: top; background-color: White">
      <TD><FONT STYLE="font-size: 10pt">23.1*</FONT></TD>
      <TD>&nbsp;</TD>
      <TD><FONT STYLE="font-size: 10pt"><A HREF="ea126543ex5-1_pluristem.htm">Consent of Sullivan &amp; Worcester LLP (contained in the opinion of Sullivan &amp; Worcester LLP filed herewith as Exhibit 5.1).</A></FONT></TD></TR>
  <TR STYLE="vertical-align: top; background-color: rgb(204,238,255)">
      <TD><FONT STYLE="font-size: 10pt">23.2*</FONT></TD>
      <TD>&nbsp;</TD>
      <TD><FONT STYLE="font-size: 10pt"><A HREF="ea126543ex23-2_pluristem.htm">Consent of Kost Forer Gabbay &amp; Kasierer, a member of Ernst &amp; Young Global.</A></FONT></TD></TR>
  <TR STYLE="vertical-align: top; background-color: White">
      <TD><FONT STYLE="font-size: 10pt">24.1*</FONT></TD>
      <TD>&nbsp;</TD>
      <TD><FONT STYLE="font-size: 10pt"><A HREF="#a_022">Powers of Attorney (included in the signature page to this registration statement).</A></FONT></TD></TR>
  <TR STYLE="vertical-align: top; background-color: rgb(204,238,255)">
      <TD><FONT STYLE="font-size: 10pt">99.1</FONT></TD>
      <TD>&nbsp;</TD>
      <TD><A HREF="http://www.sec.gov/Archives/edgar/data/1158780/000117891316004972/zk1618299.htm"><FONT STYLE="font-size: 10pt">The Company&rsquo;s 2016 Equity Compensation Plan (incorporated by reference from the Company&rsquo;s definitive proxy statement on Schedule 14A filed with the Commission on April 4, 2016).</FONT></A></TD></TR>
  </TABLE>
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
  
  <TABLE CELLPADDING="0" CELLSPACING="0" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; width: 100%"><TR STYLE="vertical-align: top; text-align: justify">
  <TD STYLE="width: 0"></TD><TD STYLE="width: 0.25in; text-align: left">*</TD><TD STYLE="text-align: justify">Filed herewith.</TD>
  </TR></TABLE>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"></P>
  
  <!-- Field: Page; Sequence: 4; Value: 1 -->
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  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>SIGNATURES</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">Pursuant to the requirements of the Securities
  Act, the registrant certifies that it has reasonable grounds to believe that it meets all of the requirements for filing on Form
  S-8 and has duly caused this registration statement to be signed on its behalf by the undersigned, thereunto duly authorized, in
  the city of Haifa, Israel, on September 9, 2020.</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
  
  <TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
  <TR STYLE="vertical-align: top">
      <TD>&nbsp;</TD>
      <TD COLSPAN="2">
          <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B>PLURISTEM THERAPEUTICS INC.</B></P>
          <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P></TD>
      </TR>
  <TR STYLE="vertical-align: top">
      <TD STYLE="padding-bottom: 1.5pt; width: 60%">&nbsp;</TD>
      <TD STYLE="width: 3%"><FONT STYLE="font-size: 10pt">By:</FONT></TD>
      <TD STYLE="border-bottom: Black 1.5pt solid; width: 37%"><FONT STYLE="font-size: 10pt">/s/ Yaky Yanay</FONT></TD>
      </TR>
  <TR STYLE="vertical-align: top">
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD><FONT STYLE="font-size: 10pt">Yaky Yanay</FONT></TD>
      </TR>
  <TR STYLE="vertical-align: top">
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD><FONT STYLE="font-size: 10pt">Chief Executive Officer</FONT></TD>
      </TR>
  </TABLE>
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B><A NAME="a_022"></A>POWER OF ATTORNEY AND SIGNATURES</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">We, the undersigned officers and directors
  of Pluristem Therapeutics Inc., hereby constitute and appoint Yaky Yanay and Chen Franco-Yehuda and each of them singly, our true
  and lawful attorneys-in-fact, with full power to them in any and all capacities, to sign any and all amendments to this registration
  statement on Form S-8 (including any post-effective amendments thereto), and to file the same, with exhibits thereto and other
  documents in connection therewith, with the Commission, hereby ratifying and confirming all that each of said attorneys-in-fact
  may do or cause to be done by virtue hereof.</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">Pursuant to the requirements of the Securities
  Act, this registration statement has been signed by the following persons in the capacities and on the dates indicated.</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
  
  <TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
  <TR STYLE="vertical-align: top">
      <TD STYLE="border-bottom: Black 1.5pt solid; text-align: center; width: 28%"><FONT STYLE="font: 10pt Times New Roman, Times, Serif"><B>Signature</B></FONT></TD>
      <TD STYLE="text-align: center; padding-bottom: 1.5pt; width: 2%">&nbsp;</TD>
      <TD STYLE="border-bottom: Black 1.5pt solid; text-align: center; width: 48%"><FONT STYLE="font: 10pt Times New Roman, Times, Serif"><B>Title</B></FONT></TD>
      <TD STYLE="text-align: center; padding-bottom: 1.5pt; width: 2%">&nbsp;</TD>
      <TD STYLE="border-bottom: Black 1.5pt solid; text-align: center; width: 20%"><FONT STYLE="font: 10pt Times New Roman, Times, Serif"><B>Date</B></FONT></TD></TR>
  <TR STYLE="vertical-align: top">
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD STYLE="text-align: center">&nbsp;</TD></TR>
  <TR STYLE="vertical-align: top">
      <TD STYLE="border-bottom: Black 1.5pt solid"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">/s/ Yaky Yanay</FONT></TD>
      <TD>&nbsp;</TD>
      <TD><FONT STYLE="font: 10pt Times New Roman, Times, Serif">Chief Executive Officer, President and Director</FONT></TD>
      <TD>&nbsp;</TD>
      <TD STYLE="text-align: center"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">September 9, 2020</FONT></TD></TR>
  <TR STYLE="vertical-align: top">
      <TD><FONT STYLE="font: 10pt Times New Roman, Times, Serif">Yaky Yanay</FONT></TD>
      <TD>&nbsp;</TD>
      <TD><FONT STYLE="font: 10pt Times New Roman, Times, Serif">(Principal Executive Officer)</FONT></TD>
      <TD>&nbsp;</TD>
      <TD STYLE="text-align: center">&nbsp;</TD></TR>
  <TR STYLE="vertical-align: top">
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD STYLE="text-align: center">&nbsp;</TD></TR>
  <TR STYLE="vertical-align: top">
      <TD STYLE="border-bottom: Black 1.5pt solid"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">/s/ <FONT>Chen Franco-Yehuda</FONT></FONT></TD>
      <TD>&nbsp;</TD>
      <TD><FONT STYLE="font: 10pt Times New Roman, Times, Serif">Chief Financial Officer and Treasurer</FONT></TD>
      <TD>&nbsp;</TD>
      <TD STYLE="text-align: center"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">September 9, 2020</FONT></TD></TR>
  <TR STYLE="vertical-align: top">
      <TD><FONT STYLE="font: 10pt Times New Roman, Times, Serif">Chen Franco-Yehuda</FONT></TD>
      <TD>&nbsp;</TD>
      <TD><FONT STYLE="font: 10pt Times New Roman, Times, Serif">(Principal Financial and Accounting Officer) </FONT></TD>
      <TD>&nbsp;</TD>
      <TD STYLE="text-align: center">&nbsp;</TD></TR>
  <TR STYLE="vertical-align: top">
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD STYLE="text-align: center">&nbsp;</TD></TR>
  <TR STYLE="vertical-align: top">
      <TD STYLE="border-bottom: Black 1.5pt solid"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">/s/ <FONT>Zami Aberman</FONT></FONT></TD>
      <TD>&nbsp;</TD>
      <TD><FONT STYLE="font: 10pt Times New Roman, Times, Serif">Executive Chairman of the Board of Directors</FONT></TD>
      <TD>&nbsp;</TD>
      <TD STYLE="text-align: center"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">September 9, 2020</FONT></TD></TR>
  <TR STYLE="vertical-align: top">
      <TD><FONT STYLE="font: 10pt Times New Roman, Times, Serif">Zami Aberman</FONT></TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD STYLE="text-align: center">&nbsp;</TD></TR>
  <TR STYLE="vertical-align: top">
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD STYLE="text-align: center">&nbsp;</TD></TR>
  <TR STYLE="vertical-align: top">
      <TD STYLE="border-bottom: Black 1.5pt solid"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">/s/ <FONT>Isaac Braun</FONT></FONT></TD>
      <TD>&nbsp;</TD>
      <TD><FONT STYLE="font: 10pt Times New Roman, Times, Serif">Director</FONT></TD>
      <TD>&nbsp;</TD>
      <TD STYLE="text-align: center"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">September 9, 2020</FONT></TD></TR>
  <TR STYLE="vertical-align: top">
      <TD><FONT STYLE="font: 10pt Times New Roman, Times, Serif">Isaac Braun</FONT></TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD STYLE="text-align: center">&nbsp;</TD></TR>
  <TR STYLE="vertical-align: top">
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD STYLE="text-align: center">&nbsp;</TD></TR>
  <TR STYLE="vertical-align: top">
      <TD STYLE="border-bottom: Black 1.5pt solid"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">/s/ <FONT>Mark Germain</FONT></FONT></TD>
      <TD>&nbsp;</TD>
      <TD><FONT STYLE="font: 10pt Times New Roman, Times, Serif">Director</FONT></TD>
      <TD>&nbsp;</TD>
      <TD STYLE="text-align: center"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">September 9, 2020</FONT></TD></TR>
  <TR STYLE="vertical-align: top">
      <TD><FONT STYLE="font: 10pt Times New Roman, Times, Serif">Mark Germain</FONT></TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD STYLE="text-align: center">&nbsp;</TD></TR>
  <TR STYLE="vertical-align: top">
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD STYLE="text-align: center">&nbsp;</TD></TR>
  <TR STYLE="vertical-align: top">
      <TD STYLE="border-bottom: Black 1.5pt solid"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">/s/ <FONT>Moria Kwiat</FONT></FONT></TD>
      <TD>&nbsp;</TD>
      <TD><FONT STYLE="font: 10pt Times New Roman, Times, Serif">Director</FONT></TD>
      <TD>&nbsp;</TD>
      <TD STYLE="text-align: center"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">September 9, 2020</FONT></TD></TR>
  <TR STYLE="vertical-align: top">
      <TD><FONT STYLE="font: 10pt Times New Roman, Times, Serif">Moria Kwiat</FONT></TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD STYLE="text-align: center">&nbsp;</TD></TR>
  <TR STYLE="vertical-align: top">
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD STYLE="text-align: center">&nbsp;</TD></TR>
  <TR STYLE="vertical-align: top">
      <TD STYLE="border-bottom: Black 1.5pt solid"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">/s/ <FONT>Doron Shorrer</FONT></FONT></TD>
      <TD>&nbsp;</TD>
      <TD><FONT STYLE="font: 10pt Times New Roman, Times, Serif">Director</FONT></TD>
      <TD>&nbsp;</TD>
      <TD STYLE="text-align: center"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">September 9, 2020</FONT></TD></TR>
  <TR STYLE="vertical-align: top">
      <TD><FONT STYLE="font: 10pt Times New Roman, Times, Serif">Doron Shorrer</FONT></TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD STYLE="text-align: center">&nbsp;</TD></TR>
  </TABLE>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
  
  <P STYLE="text-align: center; font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt">3</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"></P>
  
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metadata_filer: {"company-data": {"conformed-name": "PLURISTEM THERAPEUTICS INC", "cik": "0001158780", "assigned-sic": "2836", "irs-number": "980351734", "state-of-incorporation": "NV", "fiscal-year-end": "0630"}, "filing-values": {"form-type": "S-8", "act": "33", "file-number": "333-248686", "film-number": "201166700"}, "business-address": {"street1": "MATAM ADVANCED TECHNOLOGY PARK", "street2": "BUILDING NO. 5", "city": "HAIFA", "state": "L3", "zip": "3508409", "phone": "972-74-710-7171"}, "mail-address": {"street1": "MATAM ADVANCED TECHNOLOGY PARK", "street2": "BUILDING NO. 5", "city": "HAIFA", "state": "L3", "zip": "3508409"}, "former-company": [{"former-conformed-name": "PLURISTEM LIFE SYSTEMS INC", "date-changed": "20030701"}, {"former-conformed-name": "AI SOFTWARE INC", "date-changed": "20010906"}]}
text: As filed with the Securities and Exchange
  Commission on September 9, 2020
  Registration No. 333-
  UNITED STATES
  SECURITIES AND EXCHANGE COMMISSION
  Washington, D.C. 20549
  FORM S-8
  REGISTRATION STATEMENT UNDER THE SECURITIES
  ACT OF 1933
  PLURISTEM THERAPEUTICS INC.
  (Exact name of registrant as specified in
  its charter)
  Nevada
  98-0351734
  (State or other jurisdiction of
  incorporation or organization)
  (I.R.S. Employer
  Identification No.)
  MATAM Advanced Technology Park,
  Building No. 5,
      Haifa, Israel
  3508409
  (Address of Principal Executive Offices)
  (Zip Code)
  Pluristem Therapeutics Inc. 2016 Equity
  Compensation Plan
  (Full title of the plan)
  Nevada Agency and Transfer Company
  50 West Liberty Street, Suite 880
  Reno, NV 89501
  (Name and address of agent for service)
  (775) 322-0626
  (Telephone number, including area code,
  of agent for service)
  Copy to:
  Oded Har-Even
  Howard E. Berkenblit
  Ron Ben-Bassat
  Sullivan & Worcester LLP
  One Post Office Square
  Boston, Massachusetts 02110
  Telephone: (617) 338-2800
  Fax: (617) 338-2880
  Indicate by check mark whether the registrant is a large accelerated
  filer, an accelerated non-accelerated filer, smaller reporting company, or an emerging growth company. See definitions of "large
  accelerated filer," "accelerated filer," "smaller reporting company," and "emerging growth
  company" in Rule 12b-2 of the Exchange Act.
  Large accelerated filer  ☐
  Accelerated filer
  ☐
  Non-accelerated filer
  ☒
  Smaller reporting company  ☒
  Emerging growth company  ☐
  If an emerging growth company, indicate by check mark if the
  registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards
  provided pursuant to Section 13(a) of the Exchange Act.  ☐
  CALCULATION OF REGISTRATION FEE
  Title of securities to be
                                                                                                                 registered
  Amount
  to be
  registered (1)
  Proposed
  maximum
  offering
  price per
  share (2)
  Proposed
  maximum
  aggregate
  offering
  price (2)
  Amount
  of
  registration fee
  Common Stock, $0.00001 par value (3)
  150,000
  $
  9.72
  $
  1,458,000
  $
  189.25
  (1)
  In accordance with Rule 416(a) under the Securities Act
  of 1933, as amended, or the Securities Act, this registration statement shall be deemed to cover an indeterminate number of additional
  securities that may from time to time be offered or issued to prevent dilution resulting from stock splits, stock dividends or
  similar transactions.
  (2)
  Estimated in accordance with Rules 457(h)(1) and 457(c)
  promulgated under the Securities Act, solely for the purpose of calculating the registration fee, based on $9.72 the average of
  the high and low sales prices of the Common Stock on the Nasdaq Capital Market on September 4, 2020.
  (3)
  Represents shares of Common Stock issuable upon stock options
  or other awards to be granted pursuant to the Pluristem Therapeutics Inc. 2016 Equity Compensation Plan, or the 2016 Plan.
  EXPLANATORY
  NOTE
  On
  June 29, 2016, the Company filed a Registration Statement on Form S-8 (File No. 333-212299), or the Original Registration Statement,
  with the Securities and Exchange Commission, or the Commission, t
  o register an aggregate of 2,614,197 shares of Common Stock
  of the Company that may be issued pursuant to the 2016 Plan.
  On May 8, 2017, the Company filed
  a
  Registration Statement on Form S-8 (File No. 333-217770), or the Second Registration Statement
  ,
  with the Commission
  to register an additional 2,527,000 shares of Common Stock of the Company that may be issued pursuant to the 2016 Plan.
  On February 6, 2018, the Company filed a
  Registration Statement on Form S-8 (File No. 333-222888), or the Third Registration Statement, with the Commission to register
  an additional 3,450,000 shares of Common Stock of the Company that may be issued pursuant to the 2016 Plan.
  On February 6, 2019, the Company filed a
  Registration Statement on Form S-8 (File No. 333-229535), or the Fourth Registration Statement, with the Commission to register
  an additional 3,450,000 shares of Common Stock of the Company that may be issued pursuant to the 2016 Plan.
  Pursuant to the 2016 Plan, the number of
  shares of Common Stock of the Company made available under the 2016 Plan shall not exceed 2.75% of the number of shares of Common
  Stock of the Company issued and outstanding on a fully diluted basis on the immediately preceding December 31.
  The
  Company is filing this Registration Statement on Form S-8 to register an additional 150,000 shares of Common Stock of the Company, which
  may be issued in connection with securities awards which may hereafter  be granted under the 2016 Plan.
  Pursuant to General Instruction E to Form
  S-8, the contents of the Original Registration Statement, the Second Registration Statement, the Third Registration Statement and
  the Fourth Registration Statement, or collectively, the Prior Registration Statement, are incorporated herein by reference, except
  for Item 3 and Item 8 of Part II of the Prior Registration Statements, which are being updated by this registration statement.
  1
  PART II
  INFORMATION REQUIRED IN THE REGISTRATION
  STATEMENT
  Item 3.  Incorporation of Documents by Reference.
  The following additional documents, which
  have been filed by the Company with the Commission under the Securities Exchange Act of 1934, as amended, or the Exchange
  Act, are incorporated by reference in and made a part of this registration statement, as of their respective dates:
  (a) Our Annual Report on
  Form 10-K
  for the
  year ended June 30, 2019 filed with the SEC on September 12, 2019;
  (b) Our Quarterly Reports on Form 10-Q for
  the quarters ended
  September 30, 2019
  ,
  December 31, 2019
  and
  March 31, 2020
  , as filed with the SEC on November 7, 2019, February
  6, 2020 and May 11, 2020, respectively;
  (c) Our Current Reports on Form 8-K filed
  with the SEC on
  July 2, 2019
  ,
  July 25, 2019
  ,
  August 12, 2019
  ,
  March 3, 2020
  ,
  March 12, 2020
  ,
  March 26, 2020
  ,
  March 30, 2020
  ,
  April 7, 2020
  ,
  April 13, 2020
  ,
  April 24, 2020
  ,
  April 30, 2020
  ,
  May 5, 2020
  ,
  May 8, 2020
  ,
  May 14, 2020
  ,
  June 11, 2020
  ,
  July 1, 2020
  ,
  July 16, 2020
  ,
  July 21, 2020
  ,
  August 10, 2020
  and
  August 27, 2020
  ; and
  (d) The description of the Company's
  Common Stock contained in the Registration Statement on
  Form 8-A
  filed with the Commission on December 10, 2007, under the Exchange
  Act, including any amendment or report filed or to be filed for the purpose of updating such description.
  In addition to the foregoing, all documents
  subsequently filed by the Company pursuant to Sections 13(a), 13(c), 14 and 15(d) of the Exchange Act subsequently filed by the
  Company prior to the filing of a post-effective amendment which indicates that all securities offered hereunder have been sold
  or which deregisters all securities then remaining unsold, shall be deemed to be incorporated by reference herein and to be part
  hereof from the date of filing of such documents and reports.
  Any statement contained in a document incorporated
  or deemed to be incorporated by reference herein shall be deemed to be modified or superseded for purposes of this registration
  statement to the extent that a statement herein, or in any subsequently filed document which also is or is deemed to be incorporated
  by reference, modifies or supersedes such statement.  Any statement so modified or superseded shall not be deemed, except
  as so modified or superseded, to constitute a part of this Registration Statement.
  Item 8.  Exhibits.
  Exhibit No.
  Description
  4.1
  Composite Copy of the Company's Articles of Incorporation as amended on July 2, 2020 (incorporated by reference to Exhibit 4.1 of our registration statement on Form S-3 filed on July 16, 2020).
  4.2
  Amended and Restated By-laws (incorporated by reference to Exhibit 3.1 of the Company's Current Report on Form 8-K filed with the SEC on March 29, 2017).
  5.1*
  Opinion of Sullivan & Worcester LLP.
  23.1*
  Consent of Sullivan & Worcester LLP (contained in the opinion of Sullivan & Worcester LLP filed herewith as Exhibit 5.1).
  23.2*
  Consent of Kost Forer Gabbay & Kasierer, a member of Ernst & Young Global.
  24.1*
  Powers of Attorney (included in the signature page to this registration statement).
  99.1
  The Company's 2016 Equity Compensation Plan (incorporated by reference from the Company's definitive proxy statement on Schedule 14A filed with the Commission on April 4, 2016).
  *
  Filed herewith.
  2
  SIGNATURES
  Pursuant to the requirements of the Securities
  Act, the registrant certifies that it has reasonable grounds to believe that it meets all of the requirements for filing on Form
  S-8 and has duly caused this registration statement to be signed on its behalf by the undersigned, thereunto duly authorized, in
  the city of Haifa, Israel, on September 9, 2020.
  PLURISTEM THERAPEUTICS INC.
  By:
  /s/ Yaky Yanay
  Yaky Yanay
  Chief Executive Officer
  POWER OF ATTORNEY AND SIGNATURES
  We, the undersigned officers and directors
  of Pluristem Therapeutics Inc., hereby constitute and appoint Yaky Yanay and Chen Franco-Yehuda and each of them singly, our true
  and lawful attorneys-in-fact, with full power to them in any and all capacities, to sign any and all amendments to this registration
  statement on Form S-8 (including any post-effective amendments thereto), and to file the same, with exhibits thereto and other
  documents in connection therewith, with the Commission, hereby ratifying and confirming all that each of said attorneys-in-fact
  may do or cause to be done by virtue hereof.
  Pursuant to the requirements of the Securities
  Act, this registration statement has been signed by the following persons in the capacities and on the dates indicated.
  Signature
  Title
  Date
  /s/ Yaky Yanay
  Chief Executive Officer, President and Director
  September 9, 2020
  Yaky Yanay
  (Principal Executive Officer)
  /s/
  Chen Franco-Yehuda
  Chief Financial Officer and Treasurer
  September 9, 2020
  Chen Franco-Yehuda
  (Principal Financial and Accounting Officer)
  /s/
  Zami Aberman
  Executive Chairman of the Board of Directors
  September 9, 2020
  Zami Aberman
  /s/
  Isaac Braun
  Director
  September 9, 2020
  Isaac Braun
  /s/
  Mark Germain
  Director
  September 9, 2020
  Mark Germain
  /s/
  Moria Kwiat
  Director
  September 9, 2020
  Moria Kwiat
  /s/
  Doron Shorrer
  Director
  September 9, 2020
  Doron Shorrer
  3