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      <TD noWrap align=center width="100%"><FONT face=serif size=2><FONT size=3>&nbsp;</FONT><STRONG>As filed with the Securities and Exchange
        Commission on August 13, 2008</STRONG></FONT>&nbsp;</TD></TR>
    <TR vAlign=bottom>
      <TD noWrap align=right width="100%">&nbsp;<B><FONT face=serif size=2>Registration No. 333_____</FONT></B></TD></TR>
    <TR>
      <TD style="BORDER-BOTTOM: #000000 2pt solid" noWrap align=right width="100%"><STRONG><FONT size=1>&nbsp;</FONT></STRONG></TD></TR></TABLE><BR>
  <P align=center><B><FONT face=serif size=5>SECURITIES AND
  EXCHANGE<BR>COMMISSION<BR></FONT></B><B><FONT face=serif>Washington, D.C.
  20549</FONT></B></P>
  <P align=center><STRONG>________________</STRONG></P>
  <P align=center><B><FONT face=serif size=5>FORM S-8<BR></FONT></B><B><FONT face=serif>REGISTRATION STATEMENT UNDER<BR></FONT></B><FONT face=serif>THE
  SECURITIES ACT OF 1933<BR><STRONG>________________</STRONG></FONT></P>
  <P align=center><B><FONT face=serif size=6>ENTERPRISE FINANCIAL
  SERVICES<BR>CORP<BR></FONT></B><B><FONT face=serif size=1>(Exact name of
  registrant as specified in its charter)</FONT></B></P>
  <TABLE cellSpacing=0 cellPadding=0 width="100%" border=0>
  
    <TR vAlign=bottom>
      <TD noWrap align=center width="49%"><FONT face=serif size=2><FONT size=3>&nbsp;</FONT><STRONG>Delaware</STRONG></FONT>&nbsp;</TD>
      <TD noWrap align=center width="50%"><FONT face=serif size=2><FONT size=3>&nbsp;</FONT><STRONG>43-1706529</STRONG></FONT>&nbsp;</TD></TR>
    <TR vAlign=bottom>
      <TD noWrap align=center width="49%"><FONT face=serif size=1><FONT size=3>&nbsp;</FONT><STRONG>(State or other
      jurisdiction</STRONG></FONT>&nbsp;</TD>
      <TD noWrap align=center width="50%"><FONT face=serif size=1><FONT size=3>&nbsp;</FONT><STRONG>(I.R.S. Employer</STRONG></FONT>&nbsp;</TD></TR>
    <TR vAlign=bottom>
      <TD noWrap align=center width="49%"><FONT face=serif size=1><FONT size=3>&nbsp;</FONT><STRONG>of incorporation or
        organization)</STRONG></FONT>&nbsp;</TD>
      <TD noWrap align=center width="50%"><FONT face=serif size=1><FONT size=3>&nbsp;</FONT><STRONG>Identification
    No.)</STRONG></FONT>&nbsp;</TD></TR></TABLE><BR>
  <P align=center><B><FONT face=serif size=2>150 North Meramec</FONT></B><FONT face=serif><BR></FONT><B><FONT face=serif size=2>Clayton, Missouri
  63105<BR></FONT></B><B><FONT face=serif size=1>(Address, including zip code, and
  telephone number, including area code, of registrant&#146;s principal executive
  offices)</FONT></B></P>
  <P align=center><B><FONT face=serif size=2>Enterprise Financial Services Corp
  Amended and Restated 2002 Stock Incentive Plan<BR></FONT></B><B><FONT face=serif size=1>(Full title of the plan)</FONT></B></P>
  <TABLE cellSpacing=0 cellPadding=0 width="100%" border=0>
  
    <TR vAlign=bottom>
      <TD noWrap align=center width="49%">&nbsp; </TD>
      <TD noWrap align=center width="50%"><FONT face=serif size=2><FONT size=3>&nbsp;</FONT><STRONG>Copy to:</STRONG></FONT>&nbsp;</TD></TR>
    <TR>
      <TD align=center width="99%" colSpan=2>&nbsp; </TD></TR>
    <TR vAlign=bottom>
      <TD noWrap align=center width="49%"><FONT face=serif size=2><FONT size=3>&nbsp;</FONT><STRONG>Frank H. Sanfilippo</STRONG></FONT>&nbsp;</TD>
      <TD noWrap align=center width="50%"><FONT face=serif size=2><FONT size=3>&nbsp;</FONT><STRONG>Charles E. H. Luedde,
      Esq.</STRONG></FONT>&nbsp;</TD></TR>
    <TR vAlign=bottom>
      <TD noWrap align=center width="49%"><FONT face=serif size=2><FONT size=3>&nbsp;</FONT><STRONG>Chief Financial
      Officer</STRONG></FONT>&nbsp;</TD>
      <TD noWrap align=center width="50%"><FONT face=serif size=2><FONT size=3>&nbsp;</FONT><STRONG>Greensfelder Hemker &amp; Gale,
        P.C.</STRONG></FONT>&nbsp;</TD></TR>
    <TR vAlign=bottom>
      <TD noWrap align=center width="49%"><FONT face=serif size=2><FONT size=3>&nbsp;</FONT><STRONG>Enterprise Financial Services
        Corp</STRONG></FONT>&nbsp;</TD>
      <TD noWrap align=center width="50%"><FONT face=serif size=2><FONT size=3>&nbsp;</FONT><STRONG>10 South Broadway, Suite
      2000</STRONG></FONT>&nbsp;</TD></TR>
    <TR vAlign=bottom>
      <TD noWrap align=center width="49%"><FONT face=serif size=2><FONT size=3>&nbsp;</FONT><STRONG>150 North Meramec</STRONG></FONT>&nbsp;</TD>
      <TD noWrap align=center width="50%"><FONT face=serif size=2><FONT size=3>&nbsp;</FONT><STRONG>St. Louis, Missouri
      63102</STRONG></FONT>&nbsp;</TD></TR>
    <TR vAlign=bottom>
      <TD noWrap align=center width="49%"><FONT face=serif size=2><FONT size=3>&nbsp;</FONT><STRONG>Clayton, Missouri
      63105</STRONG></FONT>&nbsp;</TD>
      <TD noWrap align=center width="50%"><FONT size=2><FONT size=3>&nbsp;</FONT><STRONG>(314) <FONT face=serif>241-9090</FONT></STRONG></FONT>&nbsp;</TD></TR>
    <TR vAlign=bottom>
      <TD noWrap align=center width="49%"><FONT face=serif size=2><FONT size=3>&nbsp;</FONT><STRONG>(314) 725-5500</STRONG></FONT>&nbsp;</TD>
      <TD noWrap align=center width="50%">&nbsp; </TD></TR>
    <TR vAlign=bottom>
      <TD noWrap align=center width="49%"><FONT face=serif size=1><FONT size=3>&nbsp;</FONT><STRONG>(Name, address and telephone
        number</STRONG></FONT>&nbsp;</TD>
      <TD noWrap align=center width="50%">&nbsp; </TD></TR>
    <TR vAlign=bottom>
      <TD noWrap align=center width="49%"><FONT face=serif size=1><FONT size=3>&nbsp;</FONT><STRONG>of agent for service)</STRONG></FONT>&nbsp;</TD>
      <TD noWrap align=center width="50%">&nbsp;
  </TD></TR></TABLE><BR>
  <P align=left><FONT face=serif size=2>Indicate by check mark whether the
  registrant is a large accelerated filer, an accelerated filer, a non-accelerated
  filer, or a smaller reporting company. See the definitions of &#147;large accelerated
  filer,&#148; &#147;accelerated filer&#148; and &#147;smaller reporting company&#148; in Rule 12b-2 of the
  Exchange Act. (Check one):</FONT></P>
  <TABLE cellSpacing=0 cellPadding=0 width="100%" border=0>
  
    <TR vAlign=bottom>
      <TD noWrap align=left width="24%"><FONT face=serif size=2>Large accelerated filer <FONT face=Wingdings>o</FONT></FONT>&nbsp; </TD>
      <TD noWrap align=left width="25%"><FONT face=serif size=2>Accelerated filer <FONT face=wingdings>&#254;</FONT></FONT>&nbsp; </TD>
      <TD noWrap align=left width="25%"><FONT face=serif size=2>Non-accelerated filer
        <FONT face=Wingdings>o</FONT></FONT>&nbsp; </TD>
      <TD noWrap align=left width="25%"><FONT face=serif size=2>Smaller reporting
        company&nbsp;</FONT><FONT face=wingdings size=2>o</FONT>&nbsp; </TD></TR></TABLE><BR>
  <P align=center><FONT face=serif size=2></FONT><FONT face=serif size=2></FONT><FONT face=serif size=2>(Do not check if a smaller reporting
  company)</FONT></P>
  
  <HR align=center width="100%" noShade SIZE=2>
  <PAGE>
  <P align=center><B><FONT face=serif size=2>CALCULATION OF REGISTRATION
  FEE</FONT></B></P>
  <TABLE style="FONT-SIZE: 12pt; LINE-HEIGHT: 14pt; BORDER-COLLAPSE: collapse" cellSpacing=0 cellPadding=0 width="100%" border=0>
  
    <TR vAlign=bottom>
      <TD noWrap align=center width="20%"></TD>
      <TD noWrap align=center width="1%"></TD>
      <TD noWrap align=center width="19%"></TD>
      <TD noWrap align=center width="1%"></TD>
      <TD noWrap align=center width="19%"><B><FONT face=serif size=2>Proposed
        Maximum</FONT></B></TD>
      <TD noWrap align=center width="1%"></TD>
      <TD noWrap align=center width="19%"><B><FONT face=serif size=2>Proposed
        Maximum</FONT></B></TD>
      <TD noWrap align=center width="1%"></TD>
      <TD noWrap align=center width="19%"></TD></TR>
    <TR vAlign=bottom>
      <TD noWrap align=center width="20%"><B><FONT face=serif size=2>Title of Securities to
        be</FONT></B></TD>
      <TD noWrap align=center width="1%"></TD>
      <TD noWrap align=center width="19%"><B><FONT face=serif size=2>Amount of
        Shares</FONT></B></TD>
      <TD noWrap align=center width="1%">&nbsp;</TD>
      <TD noWrap align=center width="19%"><B><FONT face=serif size=2>Offering Price
        Per</FONT></B></TD>
      <TD noWrap align=center width="1%"></TD>
      <TD noWrap align=center width="19%"><B><FONT face=serif size=2>Aggregate
        Offering</FONT></B></TD>
      <TD noWrap align=center width="1%"></TD>
      <TD noWrap align=center width="19%"><B><FONT face=serif size=2>Amount
    of</FONT></B></TD></TR>
    <TR vAlign=bottom>
      <TD noWrap align=center width="20%"><B><FONT face=serif size=2>Registered(1)</FONT></B></TD>
      <TD noWrap align=center width="1%">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; </TD>
      <TD noWrap align=center width="19%"><B><FONT face=serif size=2>to be
        Registered(2)</FONT></B></TD>
      <TD noWrap align=center width="1%">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; </TD>
      <TD noWrap align=center width="19%"><B><FONT face=serif size=2>Share(3)</FONT></B></TD>
      <TD noWrap align=center width="1%">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; </TD>
      <TD noWrap align=center width="19%"><B><FONT face=serif size=2>Price</FONT></B></TD>
      <TD noWrap align=center width="1%">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; </TD>
      <TD noWrap align=center width="19%"><B><FONT face=serif size=2>Registration Fee(4)</FONT></B></TD></TR>
    <TR vAlign=bottom>
      <TD noWrap align=center width="20%"><FONT face=serif size=2>Common Stock, par value
        $0.01</FONT></TD>
      <TD noWrap align=center width="1%"></TD>
      <TD noWrap align=center width="19%"><FONT face=serif size=2>750,000(5)</FONT></TD>
      <TD noWrap align=center width="1%"><FONT face=serif size=2></FONT></TD>
      <TD noWrap align=center width="19%"><FONT face=serif size=2>$19.28</FONT></TD>
      <TD noWrap align=center width="1%"></TD>
      <TD noWrap align=center width="19%"><FONT face=serif size=2>$14,460,000</FONT></TD>
      <TD noWrap align=center width="1%"><FONT face=serif size=2></FONT></TD>
      <TD noWrap align=center width="19%"><FONT size=2>$<FONT face=serif>568.28</FONT></FONT></TD></TR></TABLE><BR>
  <P align=left><FONT face=serif size=2>1 The securities to be registered include
  options and rights to acquire Common Stock.</FONT></P>
  <P align=left><FONT face=serif size=2>2 Pursuant to Rule 416, this registration
  statement covers any additional securities that may be offered or issued in
  connection with any stock split, stock dividend, recapitalization or any similar
  transaction effected without receipt of additional consideration, which results
  in an increase in Registrant&#146;s outstanding shares of Common Stock.</FONT></P>
  <P align=left><FONT face=serif size=2>3 Estimated in accordance with Rule 457(h)
  solely for purposes of calculating the registration fee and based upon the
  average of the reported high and low sale prices on August 8, 2008.</FONT></P>
  <P align=left><FONT face=serif size=2>4 Calculated pursuant to Section 6(b) of
  the Securities Act of 1933.</FONT></P>
  <P align=left><FONT face=serif size=2>5 An aggregate of 2,250,000 shares of
  common stock, par value $0.01 per share, of Enterprise Financial Services Corp
  may be offered or issued pursuant to the 2002 Stock Incentive Plan, (a) 750,000
  of which were previously registered on Form S-8 (File No. 333-130751), (b)
  750,000 of which were previously registered on Form S-8 (File No. 333-136230)
  and (c) 750,000 of which are being registered on this Form S-8.</FONT></P>
  <HR align=center width="100%" noShade SIZE=2>
  <PAGE>
  <P align=center><B><FONT face=serif size=2>EXPLANATORY NOTE</FONT></B></P>
  <P align=left>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<FONT face=serif size=2>On December
  29, 2005, Registrant filed a Form S-8 Registration Statement (File No.
  333-130751) (the &#147;2005 Registration Statement&#148;) registering 750,000 shares of
  common stock, par value $.01 per share (&#147;Common Stock&#148;), of Registrant,
  available for issuance pursuant to awards under Registrant&#146;s 2002 Stock
  Incentive Plan (the &#147;Original Plan&#148;). On August 2, 2006, Registrant filed a Form
  S-8 Registration Statement (File No. 333-136230) (the &#147;2006 Registration
  Statement&#148;) registering an additional 750,000 shares of its Common Stock in
  connection with the amendment and restatement of the Original Plan (as amended
  and restated, the &#147;Plan&#148;).</FONT></P>
  <P align=left>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<FONT face=serif size=2>This
  Registration Statement is being filed pursuant to and in accordance with General
  Instruction E of Form S-8 to register an additional 750,000 shares of Common
  Stock in connection with a further amendment and restatement of the Plan, as
  approved by Registrant&#146;s shareholders at Registrant&#146;s annual meeting held on
  April 23, 2008. The 2005 Registration Statement and the 2006 Registration
  Statement are hereby incorporated by reference.</FONT></P>
  <P align=center><B><FONT face=serif size=2>PART II. INFORMATION REQUIRED IN THE
  REGISTRATION STATEMENT</FONT></B></P>
  <P align=left><B><FONT face=serif size=2>Item 3. <U>Incorporation of Documents
  by Reference</U>.</FONT></B></P>
  <P align=left><FONT face=serif size=2><FONT size=3>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</FONT>The following documents are hereby
  incorporated by reference into this registration statement:</FONT></P>
  <P align=left>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<FONT face=serif size=2>(a)
  Registrant&#146;s Annual Report on Form 10-K for the fiscal year ended December 31,
  2007, filed with the Securities and Exchange Commission (the &#147;Commission&#148;) on
  March 14, 2008, which contained audited consolidated financial statements for
  the most recent fiscal year for which such statements have been
  filed.</FONT></P>
  <P align=left>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<FONT face=serif size=2>(b)
  Registrant&#146;s Quarterly Report on Form 10-Q filed with the Commission for the
  quarter ended March 31, 2008 filed on May 12, 2008;</FONT></P>
  <P align=left>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<FONT face=serif size=2>(c) All
  other reports filed by Registrant pursuant to Section 13(a) or 15(d) of the
  Securities Act of 1934, as amended (the &#147;Exchange Act&#148;), since the end of the
  fiscal year covered by the Annual Report on Form 10-K referred to in paragraph
  (a) above, including without limitation all Current Reports on Form 8-K filed by
  Registrant with the Commission since such date.</FONT></P>
  <P align=left>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<FONT face=serif size=2>(d) The
  description of Registrant&#146;s common stock, which is contained in a registration
  statement filed on Form S-1, by Registrant with the Commission on October 24,
  1996, registration number 333-14737.</FONT></P>
  
  <HR align=center width="100%" noShade SIZE=2>
  <PAGE>
  <P align=left>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<FONT face=serif size=2>In addition,
  all documents subsequently filed by Registrant pursuant to Sections 13(a),
  13(c), 14 and 15(d) of the Exchange Act, prior to the filing of a post-effective
  amendment which indicates that all securities offered have been sold or which
  deregisters all securities then remaining unsold, shall be deemed to be
  incorporated by reference into this registration statement and to be a part
  hereof from the date of filing of such documents. Any statement in a document
  incorporated or deemed to be incorporated by reference herein shall be deemed to
  be modified or superseded for the purposes of this registration statement to the
  extent that a statement contained herein or in any other subsequently filed
  document which also is or deemed to be incorporated by reference herein modifies
  or supersedes such statement. Any statement so modified or superseded shall not
  be deemed, except as so modified or superseded, to constitute a part of this
  registration statement. </FONT><FONT face=serif></FONT></P>
  <P align=left><B><FONT face=serif size=2>Item 4. <U>Description of
  Securities.</U></FONT></B></P>
  <P align=left><FONT face=serif size=2><FONT size=3>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</FONT>Not Applicable.</FONT></P>
  <P align=left><B><FONT face=serif size=2>Item 5. <U>Interests of Named Experts
  and Counsel.</U></FONT></B></P>
  <P align=left><FONT face=serif size=2><FONT size=3>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</FONT>Not Applicable.</FONT></P>
  <P align=left><B><FONT face=serif size=2>Item 6. <U>Indemnification of Directors
  and Officers.</U></FONT></B></P>
  <P align=left>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<FONT face=serif size=2>Section 102
  of the Delaware General Corporation Law, or DGCL, as amended, allows a
  corporation to eliminate the personal liability of directors of a corporation or
  its stockholders for monetary damages for breach of fiduciary duty as a
  director, except where the director breached the duty of loyalty, failed to act
  in good faith, engaged in intentional misconduct or knowingly violated a law,
  authorized the payment of a dividend or approved a stock repurchase in violation
  of the DGCL or obtained an improper personal benefit.</FONT></P>
  <P align=left>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<FONT face=serif size=2>Section 145
  of the DGCL provides, among other things, that Registrant may indemnify any
  person who was or is a party or is threatened to be made a party to any
  threatened, pending or completed action, suit or proceeding other than an action
  by or in the right of Registrant, by reason of the fact that the person is or
  was a director, officer, agent or employee of Registrant, or is or was serving
  at Registrant&#146;s request as a director, officer, agent or employee of another
  corporation, partnership, joint venture, trust or other enterprise, against
  expenses, including attorneys&#146; fees, judgments, fines and amounts paid in
  settlement actually and reasonably incurred by the person in connection with
  such action, suit or proceeding, if such person acting in good faith and in a
  manner he or she reasonably believed to be in the best interests, or not opposed
  to the best interests, of Registrant, and with respect to any criminal action or
  proceeding had no reasonable cause to believe his or her conduct was unlawful.
  The power to indemnify applies to actions brought by or in the right of
  Registrant as well, but only to the extent of defense expenses, reasonably
  incurred and not to any satisfaction of judgment or settlement of the claim
  itself, and with the further limitation that in such actions no indemnification
  shall be made in the event of any adjudication of liability to Registrant,
  unless the court believes that in light of all the circumstances indemnification
  should apply. Furthermore, under the DGCL, if such person is successfully on the
  merits or otherwise in the defense of any action referred to above, or in the
  defense of any claim, issue or matter therein, such person shall be indemnified
  against expenses (including attorneys&#146; fees) actually and reasonably incurred by
  such person in connection therewith.</FONT></P>
  <HR align=center width="100%" noShade SIZE=2>
  <PAGE>
  <P align=left>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<FONT face=serif size=2>Section 174
  of the DGCL provides, among other things, that a director, who willfully or
  negligently approves an unlawful payment of dividends or an unlawful purchase or
  redemption of stock, may be held liable for such actions. A director who was
  either absent when the unlawful actions were approved or dissented at the time,
  may avoid liability by causing his or her dissent to such actions to be entered
  in the books containing minutes of the meetings of the board of directors at the
  time such action occurred or immediately after such absent director receives
  notice of the unlawful acts.</FONT></P>
  <P align=left>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<FONT face=serif size=2>As permitted
  by the DGCL, Registrant&#146;s certificate of incorporation includes a provision to
  eliminate the personal liability of its directors for monetary damages for
  breach of alleged breach of their fiduciary duties as directors, subject to
  limited exceptions. The certificate of incorporation also provides that every
  person who is or was our director, officer, employee or agent or is or was a
  director, officer, trustee, employee or agent of any other enterprise, serving
  as such at Registrant&#146;s request, shall be indemnified to the fullest extent
  permitted by law for all expenses and liabilities in connection with any
  proceeding involving such person in this capacity.</FONT></P>
  <P align=left><B><FONT face=serif size=2>Item 7. <U>Exemption from Registration
  Claimed.</U></FONT></B></P>
  <P align=left><FONT face=serif size=2><FONT size=3>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</FONT>Not Applicable.</FONT></P>
  <P align=left><B><FONT face=serif size=2>Item 8. <U>Exhibits.</U></FONT></B></P>
  <P align=left>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<FONT face=serif size=2>The Exhibits
  to this registration statement are listed in the Index to Exhibits which
  immediately follows the signature pages hereto.</FONT></P>
  <P align=left><B><FONT face=serif size=2>Item 9.
  <U>Undertakings.</U></FONT></B></P>
  <P align=left><FONT face=serif size=2><FONT size=3>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</FONT>Registrant hereby
  undertakes:</FONT></P>
  <P align=left>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<FONT face=serif size=2>(a) To file,
  during any period in which offers or sales are being made, a post-effective
  amendment to this registration statement:</FONT></P>
  <P align=left>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<FONT face=serif size=2>To include
  any material information with respect to the plan of distribution not previously
  disclosed in the registration statement or any material change to such
  information in the registration statement.</FONT></P>
  <P align=left>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<FONT face=serif size=2>(b) That,
  for the purpose of determining any liability under the Securities Act, each such
  post-effective amendment shall be deemed to be a new registration statement
  relating to the securities offered therein, and the offering of such securities
  at that time shall be deemed to be the initial bona fide offering
  thereof.</FONT></P>
  <P align=left>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<FONT face=serif size=2>(c) To
  remove from registration by means of a post-effective amendment any of the
  securities being registered which remain unsold at the termination of the
  offering.</FONT></P>
  <HR align=center width="100%" noShade SIZE=2>
  <PAGE>
  <P align=left>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<FONT face=serif size=2>Registrant
  hereby undertakes that, for purposes of determining any liability under the
  Securities Act, each filing of Registrant&#146;s annual report pursuant to Section
  13(a) or Section 15(d) of the Exchange Act (and, where applicable, each filing
  of an employee benefit plan&#146;s annual report pursuant to Section 15(d) of the
  Exchange Act) that is incorporated by reference in the registration statement
  shall be deemed to be a new registration statement relating to the securities
  offered therein, and the offering of such securities at that time shall be
  deemed to be the initial bona file offering thereof.</FONT></P>
  <P align=left>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<FONT face=serif size=2>Insofar as
  indemnification for liabilities arising under the Securities Act may be
  permitted to directors, officers and controlling persons of Registrant pursuant
  to the foregoing provisions, or otherwise, Registrant has been advised that in
  the opinion of the Commission such indemnification is against public policy as
  expressed in the Securities Act and is, therefore, unenforceable. In the event
  that a claim for indemnification against such liabilities (other than the
  payment by Registrant of expenses incurred or paid by a director, officer, or
  controlling person of Registrant in the successful defense of any action, suit
  or proceeding) is asserted by such director, officer or controlling person in
  connection with the securities being registered, Registrant will, unless in the
  opinion of its counsel the matter has been settled by controlling precedent,
  submit to a court of appropriate jurisdiction the question whether such
  indemnification by it is against public policy as expressed in the Securities
  Act and will be governed by the final adjudication of such issue.</FONT></P>
  <P align=center><B><FONT face=serif size=2>SIGNATURES</FONT></B></P>
  <P align=left>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<FONT face=serif size=2>Pursuant to
  the requirements of the Securities Act of 1933, as amended, Registrant certifies
  that it has reasonable grounds to believe that it meets all the requirements for
  filing on Form S-8 and has duly caused this Post-Effective Amendment to the
  Registration Statements to be signed on its behalf by the undersigned, thereunto
  duly authorized, in the County of St. Louis, State of Missouri, on August 13,
  2008.</FONT></P>
  <DIV align=right>
  <TABLE cellSpacing=0 cellPadding=0 width="50%" border=0>
  
    <TR vAlign=bottom>
      <TD noWrap align=left width="99%" colSpan=2><B><FONT face=serif size=2>ENTERPRISE FINANCIAL SERVICES CORP</FONT></B>&nbsp; </TD></TR>
    <TR>
      <TD width="99%" colSpan=2>&nbsp; </TD></TR>
    <TR vAlign=bottom>
      <TD noWrap align=left width="1%"><FONT face=serif size=2>By:</FONT>&nbsp;&nbsp; </TD>
      <TD style="BORDER-BOTTOM: #000000 1pt solid" noWrap align=left width="98%"><FONT face=serif size=2>/s/ Frank H. Sanfilippo</FONT>&nbsp;
      </TD></TR>
    <TR>
      <TD noWrap align=left width="1%"></TD>
      <TD noWrap align=left width="98%">&nbsp;</TD></TR>
    <TR vAlign=bottom>
      <TD noWrap align=left width="1%">&nbsp; </TD>
      <TD noWrap align=left width="98%"><FONT face=serif size=2>Frank H.
        Sanfilippo</FONT>&nbsp; </TD></TR>
    <TR vAlign=bottom>
      <TD noWrap align=left width="1%">&nbsp; </TD>
      <TD noWrap align=left width="98%"><FONT face=serif size=2>Chief Financial
        Officer</FONT>&nbsp; </TD></TR></TABLE>
  </DIV><BR>
  <P align=center><B><FONT face=serif size=2>POWER OF ATTORNEY</FONT></B></P>
  <P align=left><FONT face=serif size=2>We, the undersigned directors and officers
  of Enterprise Financial Services Corp (the </FONT><FONT face=serif size=2>&#147;Corporation&#148;) and each of us, do hereby constitute and appoint Peter F.
  Benoist and Frank H. Sanfilippo, or either of them, our true and lawful
  attorneys-in-fact and agents, each with full power of substitution and
  resubstitution, to do any and all acts and things in our names and on our behalf
  in our capacities as directors and officers and to execute any and all
  instruments for us and in our names in the capacities indicated above, which
  said attorneys or agents, or either of them, may deem necessary or advisable to
  enable the Corporation to comply with the Securities Act of 1933, as amended, and any rules,
  regulations and amendments (including post-effective amendments) to the
  Registration Statement, including specifically but without limitation, power and
  authority to sign for us or any of us in our names in the capacities indicated
  below, any and all amendments (including post-effective amendments) to such
  Registration Statement; and we do hereby ratify and conform all that the said
  attorneys and agents, or their substitute or substitutes, or either of them,
  shall do or cause to be done by virtue hereof.</FONT></P>
  <HR align=center width="100%" noShade SIZE=2>
  <PAGE>
  <P align=left><FONT face=serif size=2>Pursuant to the requirements of the
  Securities Act of 1933, this registration statement has been signed by the
  following persons in the capacities and on the dates indicated:</FONT></P>
  
  <TABLE style="LINE-HEIGHT: 14pt" cellSpacing=0 cellPadding=0 width="100%" border=0>
  
    <TR vAlign=bottom>
      <TD style="BORDER-BOTTOM: #000000 1pt solid" align=center width="29%"><B><FONT face=serif size=2>Signature</FONT></B> </TD>
      <TD align=center width="1%">&nbsp;&nbsp;&nbsp;&nbsp; </TD>
      <TD style="BORDER-BOTTOM: #000000 1pt solid" align=center width="39%"><B><FONT face=serif size=2>Title</FONT></B> </TD>
      <TD align=center width="1%">&nbsp;&nbsp;&nbsp;&nbsp; </TD>
      <TD style="BORDER-BOTTOM: #000000 1pt solid" align=center width="29%"><B><FONT face=serif size=2>Date</FONT></B> </TD></TR>
    <TR vAlign=bottom>
      <TD style="PADDING-BOTTOM: 6pt; BORDER-BOTTOM: #000000 1pt solid" align=left width="29%"><FONT size=2>/s/ Peter F. Benoist</FONT>&nbsp;&nbsp;&nbsp; </TD>
      <TD align=left width="1%">&nbsp;</TD>
      <TD align=center width="39%"><FONT face=serif size=2>Chief Executive
        Officer and Director</FONT>&nbsp; </TD>
      <TD align=center width="1%"></TD>
      <TD align=center width="29%"><FONT face=serif size=2>May 23,
        2008</FONT>&nbsp; </TD></TR>
    <TR vAlign=bottom>
      <TD align=left width="29%"><FONT face=serif size=2>Peter F.
        Benoist</FONT>&nbsp; </TD>
      <TD align=left width="1%"></TD>
      <TD align=center width="39%">&nbsp; </TD>
      <TD align=left width="1%"></TD>
      <TD align=left width="29%">&nbsp; </TD></TR>
    <TR>
      <TD width="99%" colSpan=5>&nbsp; </TD></TR>
    <TR>
      <TD style="PADDING-BOTTOM: 6pt; BORDER-BOTTOM: #000000 1pt solid" align=left width="29%"><FONT size=2>/s/ James J.
        Murphy</FONT>&nbsp;&nbsp;&nbsp;&nbsp; </TD>
      <TD align=left width="1%"></TD>
      <TD vAlign=bottom align=center width="39%"><FONT size=2>Director</FONT>&nbsp; </TD>
      <TD vAlign=bottom align=center width="1%"></TD>
      <TD vAlign=bottom align=center width="29%"><FONT size=2>May 23,
        2008</FONT>&nbsp; </TD></TR>
    <TR>
      <TD align=left width="29%"><FONT size=2>James J.
        Murphy</FONT>&nbsp;&nbsp;&nbsp;&nbsp; </TD>
      <TD align=left width="1%"></TD>
      <TD align=center width="39%"></TD>
      <TD align=center width="1%"></TD>
      <TD align=center width="29%"></TD></TR>
    <TR>
      <TD align=left width="29%">&nbsp; </TD>
      <TD align=left width="1%"></TD>
      <TD align=center width="39%">&nbsp;</TD>
      <TD align=center width="1%"></TD>
      <TD align=center width="29%"></TD></TR>
    <TR vAlign=bottom>
      <TD style="PADDING-BOTTOM: 6pt; BORDER-BOTTOM: #000000 1pt solid" align=left width="29%"><FONT size=2>/s/ Kevin C.
        Eichner</FONT>&nbsp;&nbsp;&nbsp;&nbsp; </TD>
      <TD align=left width="1%"></TD>
      <TD align=center width="39%"><FONT face=serif size=2>Director<FONT size=3>&nbsp; </FONT></FONT></TD>
      <TD align=center width="1%"></TD>
      <TD align=center width="29%"><FONT face=serif size=2>May 23, 2008<FONT size=3>&nbsp; </FONT></FONT></TD></TR>
    <TR vAlign=bottom>
      <TD align=left width="29%"><FONT face=serif size=2>Kevin C.
        Eichner</FONT>&nbsp; </TD>
      <TD align=left width="1%"></TD>
      <TD align=left width="39%">&nbsp; </TD>
      <TD align=left width="1%"></TD>
      <TD align=left width="29%">&nbsp; </TD></TR>
    <TR>
      <TD noWrap align=left width="29%">&nbsp;</TD>
      <TD noWrap align=left width="1%"></TD>
      <TD noWrap align=center width="39%"></TD>
      <TD noWrap align=left width="1%"></TD>
      <TD noWrap align=center width="29%"></TD></TR>
    <TR vAlign=bottom>
      <TD style="PADDING-BOTTOM: 6pt; BORDER-BOTTOM: #000000 1pt solid" noWrap align=left width="29%"><FONT size=2>/s/</FONT><FONT size=3> </FONT><FONT size=2>William H. Downey</FONT> &nbsp;</TD>
      <TD noWrap align=left width="1%">&nbsp;</TD>
      <TD vAlign=bottom noWrap align=center width="39%"><FONT face=serif size=2>Director</FONT>&nbsp; </TD>
      <TD noWrap align=left width="1%">&nbsp;</TD>
      <TD noWrap align=center width="29%"><FONT face=serif size=2>May 23,
        2008<FONT size=3>&nbsp; </FONT></FONT></TD></TR>
    <TR vAlign=bottom>
      <TD noWrap align=left width="29%"><FONT face=serif size=2>William H.
        Downey</FONT>&nbsp; </TD>
      <TD noWrap align=left width="1%"></TD>
      <TD noWrap align=center width="39%">&nbsp; </TD>
      <TD noWrap align=left width="1%"></TD>
      <TD noWrap align=center width="29%">&nbsp; </TD></TR>
    <TR>
      <TD noWrap align=left width="29%">&nbsp;</TD>
      <TD noWrap align=left width="1%"></TD>
      <TD noWrap align=center width="39%"></TD>
      <TD noWrap align=left width="1%"></TD>
      <TD noWrap align=center width="29%"></TD></TR>
    <TR vAlign=bottom>
      <TD style="PADDING-BOTTOM: 6pt; BORDER-BOTTOM: #000000 1pt solid" noWrap align=left width="29%"><FONT size=2>/s/</FONT><FONT size=3> </FONT><FONT size=2>Robert E. Guest, Jr.</FONT>&nbsp;&nbsp;&nbsp; </TD>
      <TD noWrap align=left width="1%"></TD>
      <TD noWrap align=center width="39%"><FONT face=serif size=2>Director</FONT>&nbsp; </TD>
      <TD noWrap align=left width="1%"></TD>
      <TD noWrap align=center width="29%"><FONT face=serif size=2>May 23,
        2008<FONT size=3>&nbsp; </FONT></FONT></TD></TR>
    <TR vAlign=bottom>
      <TD noWrap align=left width="29%"><FONT face=serif size=2>Robert E. Guest,
        Jr.</FONT>&nbsp; </TD>
      <TD noWrap align=left width="1%"></TD>
      <TD noWrap align=center width="39%">&nbsp; </TD>
      <TD noWrap align=left width="1%"></TD>
      <TD noWrap align=center width="29%">&nbsp; </TD></TR>
    <TR>
      <TD noWrap align=left width="29%">&nbsp;</TD>
      <TD noWrap align=left width="1%"></TD>
      <TD noWrap align=center width="39%"></TD>
      <TD noWrap align=left width="1%"></TD>
      <TD noWrap align=center width="29%"></TD></TR>
    <TR vAlign=bottom>
      <TD style="PADDING-BOTTOM: 6pt; BORDER-BOTTOM: #000000 1pt solid" noWrap align=left width="29%"><FONT size=2>/s/</FONT><FONT size=3> </FONT><FONT size=2>Lewis A. Levey</FONT>&nbsp;&nbsp;&nbsp; </TD>
      <TD noWrap align=left width="1%"></TD>
      <TD noWrap align=center width="39%"><FONT face=serif size=2>Director</FONT>&nbsp; </TD>
      <TD noWrap align=left width="1%"></TD>
      <TD noWrap align=center width="29%"><FONT face=serif size=2>May 23,
        2008<FONT size=3>&nbsp; </FONT></FONT></TD></TR>
    <TR vAlign=bottom>
      <TD noWrap align=left width="29%"><FONT face=serif size=2>Lewis A.
        Levey</FONT>&nbsp; </TD>
      <TD noWrap align=left width="1%"></TD>
      <TD noWrap align=center width="39%">&nbsp; </TD>
      <TD noWrap align=left width="1%"></TD>
      <TD noWrap align=center width="29%">&nbsp; </TD></TR>
    <TR>
      <TD noWrap align=left width="29%">&nbsp;</TD>
      <TD noWrap align=left width="1%"></TD>
      <TD noWrap align=center width="39%"></TD>
      <TD noWrap align=left width="1%"></TD>
      <TD noWrap align=center width="29%"></TD></TR>
    <TR vAlign=bottom>
      <TD style="PADDING-BOTTOM: 6pt; BORDER-BOTTOM: #000000 1pt solid" noWrap align=left width="29%"><FONT size=2>/s/</FONT><FONT size=3> </FONT><FONT size=2>Birch M. Mullins</FONT>&nbsp;&nbsp;&nbsp; </TD>
      <TD noWrap align=left width="1%"></TD>
      <TD noWrap align=center width="39%"><FONT face=serif size=2>Director</FONT>&nbsp; </TD>
      <TD noWrap align=left width="1%"></TD>
      <TD noWrap align=center width="29%"><FONT face=serif size=2>May 23,
        2008<FONT size=3>&nbsp; </FONT></FONT></TD></TR>
    <TR vAlign=bottom>
      <TD noWrap align=left width="29%"><FONT face=serif size=2>Birch M.
        Mullins</FONT>&nbsp; </TD>
      <TD noWrap align=left width="1%">&nbsp;</TD>
      <TD noWrap align=center width="39%">&nbsp; </TD>
      <TD noWrap align=left width="1%"></TD>
      <TD noWrap align=center width="29%">&nbsp; </TD></TR>
    <TR>
      <TD width="99%" colSpan=5>&nbsp; </TD></TR>
    <TR vAlign=bottom>
      <TD style="PADDING-BOTTOM: 6pt; BORDER-BOTTOM: #000000 1pt solid" noWrap align=left width="29%"><FONT size=2>/s/</FONT><FONT size=3> </FONT><FONT size=2>Robert E. Saur</FONT>&nbsp; </TD>
      <TD noWrap align=left width="1%"></TD>
      <TD noWrap align=center width="39%"><FONT face=serif size=2>Director</FONT>&nbsp; </TD>
      <TD noWrap align=left width="1%"></TD>
      <TD noWrap align=center width="29%"><FONT face=serif size=2>May 23,
        2008<FONT size=3>&nbsp; </FONT></FONT></TD></TR>
    <TR vAlign=bottom>
      <TD noWrap align=left width="29%"><FONT face=serif size=2>Robert E.
        Saur</FONT>&nbsp; </TD>
      <TD noWrap align=left width="1%"></TD>
      <TD noWrap align=center width="39%">&nbsp; </TD>
      <TD noWrap align=left width="1%"></TD>
      <TD noWrap align=center width="29%">&nbsp; </TD></TR>
    <TR>
      <TD width="99%" colSpan=5>&nbsp; </TD></TR>
    <TR vAlign=bottom>
      <TD style="PADDING-BOTTOM: 6pt; BORDER-BOTTOM: #000000 1pt solid" noWrap align=left width="29%"><FONT size=2>/s/</FONT><FONT size=3> </FONT><FONT size=2>Sandra Van Trease</FONT>&nbsp;&nbsp;&nbsp; </TD>
      <TD noWrap align=left width="1%"></TD>
      <TD noWrap align=center width="39%"><FONT face=serif size=2>Director</FONT>&nbsp; </TD>
      <TD noWrap align=left width="1%"></TD>
      <TD noWrap align=center width="29%"><FONT face=serif size=2>May 23,
        2008<FONT size=3>&nbsp; </FONT></FONT></TD></TR>
    <TR vAlign=bottom>
      <TD noWrap align=left width="29%"><FONT face=serif size=2>Sandra Van
        Trease</FONT>&nbsp; </TD>
      <TD noWrap align=left width="1%"></TD>
      <TD noWrap align=center width="39%">&nbsp; </TD>
      <TD noWrap align=left width="1%"></TD>
      <TD noWrap align=center width="29%">&nbsp; </TD></TR>
    <TR>
      <TD width="99%" colSpan=5>&nbsp; </TD></TR>
    <TR vAlign=bottom>
      <TD style="PADDING-BOTTOM: 6pt; BORDER-BOTTOM: #000000 1pt solid" noWrap align=left width="29%"><FONT size=2>/s/</FONT><FONT size=3> </FONT><FONT size=2>Henry D. Warshaw</FONT>&nbsp;&nbsp;&nbsp; </TD>
      <TD noWrap align=left width="1%"></TD>
      <TD noWrap align=center width="39%"><FONT face=serif size=2>Director</FONT>&nbsp; </TD>
      <TD noWrap align=left width="1%"></TD>
      <TD noWrap align=center width="29%"><FONT face=serif size=2>May 23,
        2008<FONT size=3>&nbsp; </FONT></FONT></TD></TR>
    <TR vAlign=bottom>
      <TD noWrap align=left width="29%"><FONT face=serif size=2>Henry D.
        Warshaw</FONT>&nbsp; </TD>
      <TD noWrap align=left width="1%"></TD>
      <TD noWrap align=center width="39%">&nbsp; </TD>
      <TD noWrap align=left width="1%"></TD>
      <TD noWrap align=center width="29%">&nbsp; </TD></TR>
    <TR>
      <TD width="99%" colSpan=5>&nbsp; </TD></TR>
    <TR vAlign=bottom>
      <TD style="PADDING-BOTTOM: 6pt; BORDER-BOTTOM: #000000 1pt solid" noWrap align=left width="29%"><FONT size=2>/s/</FONT><FONT size=3> </FONT><FONT size=2>Michael A. DeCola</FONT>&nbsp;&nbsp;&nbsp; </TD>
      <TD noWrap align=left width="1%"></TD>
      <TD noWrap align=center width="39%"><FONT face=serif size=2>Director</FONT>&nbsp; </TD>
      <TD noWrap align=left width="1%"></TD>
      <TD noWrap align=center width="29%"><FONT face=serif size=2>May 23,
        2008<FONT size=3>&nbsp; </FONT></FONT></TD></TR>
    <TR vAlign=bottom>
      <TD noWrap align=left width="29%"><FONT face=serif size=2>Michael A.
        DeCola</FONT>&nbsp; </TD>
      <TD noWrap align=left width="1%"></TD>
      <TD noWrap align=center width="39%">&nbsp; </TD>
      <TD noWrap align=left width="1%"></TD>
      <TD noWrap align=center width="29%">&nbsp; </TD></TR>
    <TR>
      <TD width="99%" colSpan=5>&nbsp; </TD></TR>
    <TR vAlign=bottom>
      <TD style="PADDING-BOTTOM: 6pt; BORDER-BOTTOM: #000000 1pt solid" noWrap align=left width="29%"><FONT face=serif size=2>/s/<FONT size=3>
        </FONT>Brenda D. Newberry</FONT>&nbsp; </TD>
      <TD noWrap align=left width="1%"></TD>
      <TD noWrap align=center width="39%"><FONT face=serif size=2>Director</FONT>&nbsp; </TD>
      <TD noWrap align=left width="1%"></TD>
      <TD noWrap align=center width="29%"><FONT face=serif size=2>May 23,
        2008<FONT size=3>&nbsp; </FONT></FONT></TD></TR>
    <TR vAlign=bottom>
      <TD noWrap align=left width="29%"><FONT face=serif size=2>Brenda D.
        Newberry</FONT>&nbsp; </TD>
      <TD noWrap align=left width="1%"></TD>
      <TD noWrap align=center width="39%">&nbsp; </TD>
      <TD noWrap align=left width="1%"></TD>
      <TD noWrap align=center width="29%">&nbsp;
  </TD></TR></TABLE>
  <BR>
  <HR align=center width="100%" noShade SIZE=2>
  
  <PAGE>
  
  <P align=center><B><U><FONT face=serif size=2>INDEX TO
  EXHIBITS</FONT></U></B><FONT face=sans-serif> </FONT></P>
  <TABLE cellSpacing=0 cellPadding=0 width="100%" border=0>
  
    <TR vAlign=bottom>
      <TD style="BORDER-BOTTOM: #000000 1pt solid" noWrap align=left width="11%"><B><FONT face=serif size=1>Exhibit No.</FONT></B> </TD>
      <TD noWrap align=left width="1%">&nbsp;&nbsp;&nbsp; </TD>
      <TD style="BORDER-BOTTOM: #000000 1pt solid" noWrap align=left width="87%"><B><FONT face=serif size=1>Description</FONT></B> </TD></TR>
    <TR vAlign=bottom>
      <TD vAlign=top align=left width="11%" bgColor=#c0c0c0><FONT face=serif size=2>4.1**</FONT></TD>
      <TD vAlign=top noWrap align=left width="1%" bgColor=#c0c0c0>&nbsp; </TD>
      <TD vAlign=top align=left width="87%" bgColor=#c0c0c0><FONT face=serif size=2>Enterprise Financial Services Corp 2002 Amended and Restated Stock
        Incentive Plan (incorporated herein by reference to Registrant&#146;s Proxy
        Statement on Form 14-A, filed on March 17, 2008).</FONT></TD></TR>
    <TR>
      <TD vAlign=top align=left width="11%"></TD>
      <TD vAlign=top noWrap align=left width="1%"></TD>
      <TD vAlign=top align=left width="87%">&nbsp;</TD></TR>
    <TR vAlign=bottom>
      <TD vAlign=top align=left width="11%" bgColor=#c0c0c0><FONT face=serif size=2>4.2*</FONT></TD>
      <TD vAlign=top noWrap align=left width="1%" bgColor=#c0c0c0><FONT face=serif size=2></FONT></TD>
      <TD vAlign=top align=left width="87%" bgColor=#c0c0c0><FONT face=serif size=2>Form of Restricted Stock Unit Agreement</FONT></TD></TR>
    <TR>
      <TD vAlign=top align=left width="11%"></TD>
      <TD vAlign=top noWrap align=left width="1%"></TD>
      <TD vAlign=top align=left width="87%">&nbsp;</TD></TR>
    <TR vAlign=bottom>
      <TD vAlign=top align=left width="11%" bgColor=#c0c0c0><FONT face=serif size=2>4.3*</FONT></TD>
      <TD vAlign=top noWrap align=left width="1%" bgColor=#c0c0c0><FONT face=serif size=2></FONT></TD>
      <TD vAlign=top align=left width="87%" bgColor=#c0c0c0><FONT face=serif size=2>Form of Stock Appreciation Right Agreement</FONT></TD></TR>
    <TR>
      <TD vAlign=top align=left width="11%"></TD>
      <TD vAlign=top noWrap align=left width="1%"></TD>
      <TD vAlign=top align=left width="87%">&nbsp;</TD></TR>
    <TR vAlign=bottom>
      <TD vAlign=top align=left width="11%" bgColor=#c0c0c0><FONT face=serif size=2>5.1*</FONT></TD>
      <TD vAlign=top noWrap align=left width="1%" bgColor=#c0c0c0><FONT face=serif size=2></FONT></TD>
      <TD vAlign=top align=left width="87%" bgColor=#c0c0c0><FONT face=serif size=2>Opinion of Greensfelder, Hemker &amp; Gale, P.C.</FONT></TD></TR>
    <TR>
      <TD vAlign=top align=left width="11%"></TD>
      <TD vAlign=top noWrap align=left width="1%"></TD>
      <TD vAlign=top align=left width="87%">&nbsp;</TD></TR>
    <TR vAlign=bottom>
      <TD vAlign=top align=left width="11%" bgColor=#c0c0c0><FONT face=serif size=2>23.1*</FONT></TD>
      <TD vAlign=top noWrap align=left width="1%" bgColor=#c0c0c0><FONT face=serif size=2></FONT></TD>
      <TD vAlign=top align=left width="87%" bgColor=#c0c0c0><FONT face=serif size=2>Consent of Independent Registered Public Accounting
    Firm</FONT></TD></TR>
    <TR>
      <TD vAlign=top align=left width="11%"></TD>
      <TD vAlign=top noWrap align=left width="1%"></TD>
      <TD vAlign=top align=left width="87%">&nbsp;</TD></TR>
    <TR vAlign=bottom>
      <TD vAlign=top align=left width="11%" bgColor=#c0c0c0><FONT face=serif size=2>23.2*</FONT></TD>
      <TD vAlign=top noWrap align=left width="1%" bgColor=#c0c0c0><FONT face=serif size=2></FONT></TD>
      <TD vAlign=top align=left width="87%" bgColor=#c0c0c0><FONT face=serif size=2>Consent of Greensfelder, Hemker &amp; Gale, P.C. (included in
        Exhibit 5.1)</FONT></TD></TR>
    <TR>
      <TD vAlign=top align=left width="11%"></TD>
      <TD vAlign=top noWrap align=left width="1%"></TD>
      <TD vAlign=top align=left width="87%">&nbsp;</TD></TR>
    <TR vAlign=bottom>
      <TD vAlign=top align=left width="11%" bgColor=#c0c0c0><FONT face=serif size=2>24.1*</FONT></TD>
      <TD vAlign=top noWrap align=left width="1%" bgColor=#c0c0c0><FONT size=2>&nbsp;</FONT></TD>
      <TD vAlign=top align=left width="87%" bgColor=#c0c0c0><FONT face=serif size=2>Power of Attorney (contained on signature
  page)</FONT></TD></TR></TABLE><BR>
  <TABLE cellSpacing=0 cellPadding=0 border=0>
  
    <TR>
      <TD vAlign=top noWrap><FONT face=serif size=2>*</FONT></TD>
      <TD vAlign=top noWrap></TD>
      <TD width="100%"><FONT face=serif size=2>Filed herewith</FONT></TD></TR>
    <TR>
      <TD vAlign=top noWrap><FONT face=serif size=2>**</FONT></TD>
      <TD vAlign=top noWrap>&nbsp;</TD>
      <TD width="100%"><FONT face=serif size=2>Previously
    Filed</FONT></TD></TR></TABLE><BR>
  <HR align=center width="100%" noShade SIZE=2>
  
  </BODY>
  
  </HTML>
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metadata_filer: {"company-data": {"conformed-name": "ENTERPRISE FINANCIAL SERVICES CORP", "cik": "0001025835", "assigned-sic": "6022", "irs-number": "431706259", "state-of-incorporation": "DE", "fiscal-year-end": "0907"}, "filing-values": {"form-type": "S-8", "act": "33", "file-number": "333-152985", "film-number": "081011835"}, "business-address": {"street1": "150 NORTH MERAMEC", "street2": "150 NORTH MERAMEC", "city": "CLAYTON", "state": "MO", "zip": "63105", "phone": "3147255500"}, "mail-address": {"street1": "150 NORTH MERAMEC", "street2": "150 NORTH MERAMEC", "city": "CLAYTON", "state": "MO", "zip": "63105"}, "former-company": {"former-conformed-name": "ENTERBANK HOLDINGS INC", "date-changed": "19961024"}}
text: As filed with the Securities and Exchange
        Commission on August 13, 2008
  Registration No. 333_____
  SECURITIES AND
  EXCHANGE
  COMMISSION
  Washington, D.C.
  20549
  ________________
  FORM S-8
  REGISTRATION STATEMENT UNDER
  THE
  SECURITIES ACT OF 1933
  ________________
  ENTERPRISE FINANCIAL
  SERVICES
  CORP
  (Exact name of
  registrant as specified in its charter)
  Delaware
  43-1706529
  (State or other
      jurisdiction
  (I.R.S. Employer
  of incorporation or
        organization)
  Identification
    No.)
  150 North Meramec
  Clayton, Missouri
  63105
  (Address, including zip code, and
  telephone number, including area code, of registrant's principal executive
  offices)
  Enterprise Financial Services Corp
  Amended and Restated 2002 Stock Incentive Plan
  (Full title of the plan)
  Copy to:
  Frank H. Sanfilippo
  Charles E. H. Luedde,
      Esq.
  Chief Financial
      Officer
  Greensfelder Hemker & Gale,
        P.C.
  Enterprise Financial Services
        Corp
  10 South Broadway, Suite
      2000
  150 North Meramec
  St. Louis, Missouri
      63102
  Clayton, Missouri
      63105
  (314)
  241-9090
  (314) 725-5500
  (Name, address and telephone
        number
  of agent for service)
  Indicate by check mark whether the
  registrant is a large accelerated filer, an accelerated filer, a non-accelerated
  filer, or a smaller reporting company. See the definitions of "large accelerated
  filer," "accelerated filer" and "smaller reporting company" in Rule 12b-2 of the
  Exchange Act. (Check one):
  Large accelerated filer
  o
  Accelerated filer
  þ
  Non-accelerated filer
  o
  Smaller reporting
        company
  o
  (Do not check if a smaller reporting
  company)
  CALCULATION OF REGISTRATION
  FEE
  Proposed
        Maximum
  Proposed
        Maximum
  Title of Securities to
        be
  Amount of
        Shares
  Offering Price
        Per
  Aggregate
        Offering
  Amount
    of
  Registered(1)
  to be
        Registered(2)
  Share(3)
  Price
  Registration Fee(4)
  Common Stock, par value
        $0.01
  750,000(5)
  $19.28
  $14,460,000
  $
  568.28
  1 The securities to be registered include
  options and rights to acquire Common Stock.
  2 Pursuant to Rule 416, this registration
  statement covers any additional securities that may be offered or issued in
  connection with any stock split, stock dividend, recapitalization or any similar
  transaction effected without receipt of additional consideration, which results
  in an increase in Registrant's outstanding shares of Common Stock.
  3 Estimated in accordance with Rule 457(h)
  solely for purposes of calculating the registration fee and based upon the
  average of the reported high and low sale prices on August 8, 2008.
  4 Calculated pursuant to Section 6(b) of
  the Securities Act of 1933.
  5 An aggregate of 2,250,000 shares of
  common stock, par value $0.01 per share, of Enterprise Financial Services Corp
  may be offered or issued pursuant to the 2002 Stock Incentive Plan, (a) 750,000
  of which were previously registered on Form S-8 (File No. 333-130751), (b)
  750,000 of which were previously registered on Form S-8 (File No. 333-136230)
  and (c) 750,000 of which are being registered on this Form S-8.
  EXPLANATORY NOTE
  On December
  29, 2005, Registrant filed a Form S-8 Registration Statement (File No.
  333-130751) (the "2005 Registration Statement") registering 750,000 shares of
  common stock, par value $.01 per share ("Common Stock"), of Registrant,
  available for issuance pursuant to awards under Registrant's 2002 Stock
  Incentive Plan (the "Original Plan"). On August 2, 2006, Registrant filed a Form
  S-8 Registration Statement (File No. 333-136230) (the "2006 Registration
  Statement") registering an additional 750,000 shares of its Common Stock in
  connection with the amendment and restatement of the Original Plan (as amended
  and restated, the "Plan").
  This
  Registration Statement is being filed pursuant to and in accordance with General
  Instruction E of Form S-8 to register an additional 750,000 shares of Common
  Stock in connection with a further amendment and restatement of the Plan, as
  approved by Registrant's shareholders at Registrant's annual meeting held on
  April 23, 2008. The 2005 Registration Statement and the 2006 Registration
  Statement are hereby incorporated by reference.
  PART II. INFORMATION REQUIRED IN THE
  REGISTRATION STATEMENT
  Item 3.
  Incorporation of Documents
  by Reference
  .
  The following documents are hereby
  incorporated by reference into this registration statement:
  (a)
  Registrant's Annual Report on Form 10-K for the fiscal year ended December 31,
  2007, filed with the Securities and Exchange Commission (the "Commission") on
  March 14, 2008, which contained audited consolidated financial statements for
  the most recent fiscal year for which such statements have been
  filed.
  (b)
  Registrant's Quarterly Report on Form 10-Q filed with the Commission for the
  quarter ended March 31, 2008 filed on May 12, 2008;
  (c) All
  other reports filed by Registrant pursuant to Section 13(a) or 15(d) of the
  Securities Act of 1934, as amended (the "Exchange Act"), since the end of the
  fiscal year covered by the Annual Report on Form 10-K referred to in paragraph
  (a) above, including without limitation all Current Reports on Form 8-K filed by
  Registrant with the Commission since such date.
  (d) The
  description of Registrant's common stock, which is contained in a registration
  statement filed on Form S-1, by Registrant with the Commission on October 24,
  1996, registration number 333-14737.
  In addition,
  all documents subsequently filed by Registrant pursuant to Sections 13(a),
  13(c), 14 and 15(d) of the Exchange Act, prior to the filing of a post-effective
  amendment which indicates that all securities offered have been sold or which
  deregisters all securities then remaining unsold, shall be deemed to be
  incorporated by reference into this registration statement and to be a part
  hereof from the date of filing of such documents. Any statement in a document
  incorporated or deemed to be incorporated by reference herein shall be deemed to
  be modified or superseded for the purposes of this registration statement to the
  extent that a statement contained herein or in any other subsequently filed
  document which also is or deemed to be incorporated by reference herein modifies
  or supersedes such statement. Any statement so modified or superseded shall not
  be deemed, except as so modified or superseded, to constitute a part of this
  registration statement.
  Item 4.
  Description of
  Securities.
  Not Applicable.
  Item 5.
  Interests of Named Experts
  and Counsel.
  Not Applicable.
  Item 6.
  Indemnification of Directors
  and Officers.
  Section 102
  of the Delaware General Corporation Law, or DGCL, as amended, allows a
  corporation to eliminate the personal liability of directors of a corporation or
  its stockholders for monetary damages for breach of fiduciary duty as a
  director, except where the director breached the duty of loyalty, failed to act
  in good faith, engaged in intentional misconduct or knowingly violated a law,
  authorized the payment of a dividend or approved a stock repurchase in violation
  of the DGCL or obtained an improper personal benefit.
  Section 145
  of the DGCL provides, among other things, that Registrant may indemnify any
  person who was or is a party or is threatened to be made a party to any
  threatened, pending or completed action, suit or proceeding other than an action
  by or in the right of Registrant, by reason of the fact that the person is or
  was a director, officer, agent or employee of Registrant, or is or was serving
  at Registrant's request as a director, officer, agent or employee of another
  corporation, partnership, joint venture, trust or other enterprise, against
  expenses, including attorneys' fees, judgments, fines and amounts paid in
  settlement actually and reasonably incurred by the person in connection with
  such action, suit or proceeding, if such person acting in good faith and in a
  manner he or she reasonably believed to be in the best interests, or not opposed
  to the best interests, of Registrant, and with respect to any criminal action or
  proceeding had no reasonable cause to believe his or her conduct was unlawful.
  The power to indemnify applies to actions brought by or in the right of
  Registrant as well, but only to the extent of defense expenses, reasonably
  incurred and not to any satisfaction of judgment or settlement of the claim
  itself, and with the further limitation that in such actions no indemnification
  shall be made in the event of any adjudication of liability to Registrant,
  unless the court believes that in light of all the circumstances indemnification
  should apply. Furthermore, under the DGCL, if such person is successfully on the
  merits or otherwise in the defense of any action referred to above, or in the
  defense of any claim, issue or matter therein, such person shall be indemnified
  against expenses (including attorneys' fees) actually and reasonably incurred by
  such person in connection therewith.
  Section 174
  of the DGCL provides, among other things, that a director, who willfully or
  negligently approves an unlawful payment of dividends or an unlawful purchase or
  redemption of stock, may be held liable for such actions. A director who was
  either absent when the unlawful actions were approved or dissented at the time,
  may avoid liability by causing his or her dissent to such actions to be entered
  in the books containing minutes of the meetings of the board of directors at the
  time such action occurred or immediately after such absent director receives
  notice of the unlawful acts.
  As permitted
  by the DGCL, Registrant's certificate of incorporation includes a provision to
  eliminate the personal liability of its directors for monetary damages for
  breach of alleged breach of their fiduciary duties as directors, subject to
  limited exceptions. The certificate of incorporation also provides that every
  person who is or was our director, officer, employee or agent or is or was a
  director, officer, trustee, employee or agent of any other enterprise, serving
  as such at Registrant's request, shall be indemnified to the fullest extent
  permitted by law for all expenses and liabilities in connection with any
  proceeding involving such person in this capacity.
  Item 7.
  Exemption from Registration
  Claimed.
  Not Applicable.
  Item 8.
  Exhibits.
  The Exhibits
  to this registration statement are listed in the Index to Exhibits which
  immediately follows the signature pages hereto.
  Item 9.
  Undertakings.
  Registrant hereby
  undertakes:
  (a) To file,
  during any period in which offers or sales are being made, a post-effective
  amendment to this registration statement:
  To include
  any material information with respect to the plan of distribution not previously
  disclosed in the registration statement or any material change to such
  information in the registration statement.
  (b) That,
  for the purpose of determining any liability under the Securities Act, each such
  post-effective amendment shall be deemed to be a new registration statement
  relating to the securities offered therein, and the offering of such securities
  at that time shall be deemed to be the initial bona fide offering
  thereof.
  (c) To
  remove from registration by means of a post-effective amendment any of the
  securities being registered which remain unsold at the termination of the
  offering.
  Registrant
  hereby undertakes that, for purposes of determining any liability under the
  Securities Act, each filing of Registrant's annual report pursuant to Section
  13(a) or Section 15(d) of the Exchange Act (and, where applicable, each filing
  of an employee benefit plan's annual report pursuant to Section 15(d) of the
  Exchange Act) that is incorporated by reference in the registration statement
  shall be deemed to be a new registration statement relating to the securities
  offered therein, and the offering of such securities at that time shall be
  deemed to be the initial bona file offering thereof.
  Insofar as
  indemnification for liabilities arising under the Securities Act may be
  permitted to directors, officers and controlling persons of Registrant pursuant
  to the foregoing provisions, or otherwise, Registrant has been advised that in
  the opinion of the Commission such indemnification is against public policy as
  expressed in the Securities Act and is, therefore, unenforceable. In the event
  that a claim for indemnification against such liabilities (other than the
  payment by Registrant of expenses incurred or paid by a director, officer, or
  controlling person of Registrant in the successful defense of any action, suit
  or proceeding) is asserted by such director, officer or controlling person in
  connection with the securities being registered, Registrant will, unless in the
  opinion of its counsel the matter has been settled by controlling precedent,
  submit to a court of appropriate jurisdiction the question whether such
  indemnification by it is against public policy as expressed in the Securities
  Act and will be governed by the final adjudication of such issue.
  SIGNATURES
  Pursuant to
  the requirements of the Securities Act of 1933, as amended, Registrant certifies
  that it has reasonable grounds to believe that it meets all the requirements for
  filing on Form S-8 and has duly caused this Post-Effective Amendment to the
  Registration Statements to be signed on its behalf by the undersigned, thereunto
  duly authorized, in the County of St. Louis, State of Missouri, on August 13,
  2008.
  ENTERPRISE FINANCIAL SERVICES CORP
  By:
  /s/ Frank H. Sanfilippo
  Frank H.
        Sanfilippo
  Chief Financial
        Officer
  POWER OF ATTORNEY
  We, the undersigned directors and officers
  of Enterprise Financial Services Corp (the
  "Corporation") and each of us, do hereby constitute and appoint Peter F.
  Benoist and Frank H. Sanfilippo, or either of them, our true and lawful
  attorneys-in-fact and agents, each with full power of substitution and
  resubstitution, to do any and all acts and things in our names and on our behalf
  in our capacities as directors and officers and to execute any and all
  instruments for us and in our names in the capacities indicated above, which
  said attorneys or agents, or either of them, may deem necessary or advisable to
  enable the Corporation to comply with the Securities Act of 1933, as amended, and any rules,
  regulations and amendments (including post-effective amendments) to the
  Registration Statement, including specifically but without limitation, power and
  authority to sign for us or any of us in our names in the capacities indicated
  below, any and all amendments (including post-effective amendments) to such
  Registration Statement; and we do hereby ratify and conform all that the said
  attorneys and agents, or their substitute or substitutes, or either of them,
  shall do or cause to be done by virtue hereof.
  Pursuant to the requirements of the
  Securities Act of 1933, this registration statement has been signed by the
  following persons in the capacities and on the dates indicated:
  Signature
  Title
  Date
  /s/ Peter F. Benoist
  Chief Executive
        Officer and Director
  May 23,
        2008
  Peter F.
        Benoist
  /s/ James J.
        Murphy
  Director
  May 23,
        2008
  James J.
        Murphy
  /s/ Kevin C.
        Eichner
  Director
  May 23, 2008
  Kevin C.
        Eichner
  /s/
  William H. Downey
  Director
  May 23,
        2008
  William H.
        Downey
  /s/
  Robert E. Guest, Jr.
  Director
  May 23,
        2008
  Robert E. Guest,
        Jr.
  /s/
  Lewis A. Levey
  Director
  May 23,
        2008
  Lewis A.
        Levey
  /s/
  Birch M. Mullins
  Director
  May 23,
        2008
  Birch M.
        Mullins
  /s/
  Robert E. Saur
  Director
  May 23,
        2008
  Robert E.
        Saur
  /s/
  Sandra Van Trease
  Director
  May 23,
        2008
  Sandra Van
        Trease
  /s/
  Henry D. Warshaw
  Director
  May 23,
        2008
  Henry D.
        Warshaw
  /s/
  Michael A. DeCola
  Director
  May 23,
        2008
  Michael A.
        DeCola
  /s/
  Brenda D. Newberry
  Director
  May 23,
        2008
  Brenda D.
        Newberry
  INDEX TO
  EXHIBITS
  Exhibit No.
  Description
  4.1**
  Enterprise Financial Services Corp 2002 Amended and Restated Stock
        Incentive Plan (incorporated herein by reference to Registrant's Proxy
        Statement on Form 14-A, filed on March 17, 2008).
  4.2*
  Form of Restricted Stock Unit Agreement
  4.3*
  Form of Stock Appreciation Right Agreement
  5.1*
  Opinion of Greensfelder, Hemker & Gale, P.C.
  23.1*
  Consent of Independent Registered Public Accounting
    Firm
  23.2*
  Consent of Greensfelder, Hemker & Gale, P.C. (included in
        Exhibit 5.1)
  24.1*
  Power of Attorney (contained on signature
  page)
  *
  Filed herewith
  **
  Previously
    Filed