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  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 153pt; text-align: center"><P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">As
  filed with the Securities and Exchange Commission on November 9, 2021</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: right">Registration No. 333-</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: right"></P>
  
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  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: right">&nbsp;</P>
  
  <P STYLE="font: bold 14pt Times New Roman, Times, Serif; margin: 0pt 0; text-transform: uppercase; text-align: center">UNITED STATES<BR>
  SECURITIES AND EXCHANGE COMMISSION</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">Washington, D.C. 20549</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>
  
  
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"></P>
  
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  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>
  
  
  
  <P STYLE="font: bold 16pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">FORM S-8</P>
  
  <P STYLE="font: bold 14pt Times New Roman, Times, Serif; margin: 0pt 0; text-transform: uppercase; text-align: center">REGISTRATION
  STATEMENT<BR>
  UNDER<BR>
  THE SECURITIES ACT OF 1933</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"></P>
  
  
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>
  
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  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>
  
  <P STYLE="font: bold 18pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">ENZO BIOCHEM, INC.</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><I>(Exact name of Registrant as specified
  in its charter)</I></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><I>&nbsp;</I></P>
  
  <TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
    <TR STYLE="vertical-align: top">
      <TD STYLE="border-bottom: Black 1.5pt solid; width: 50%; text-align: center"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt"><B>New York</B></FONT></TD>
      <TD STYLE="padding-bottom: 1.5pt; width: 1%; text-align: center">&nbsp;</TD>
      <TD STYLE="border-bottom: Black 1.5pt solid; width: 49%; text-align: center"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt"><B>13-2866202</B></FONT></TD></TR>
    <TR STYLE="vertical-align: top">
      <TD STYLE="text-align: center"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt"><I>(State or Other
      Jurisdiction of </I></FONT></TD>
      <TD STYLE="text-align: center">&nbsp;</TD>
      <TD STYLE="text-align: center"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt"><I>(I.R.S. Employer</I></FONT></TD></TR>
    <TR STYLE="vertical-align: top">
      <TD STYLE="text-align: center"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt"><I>Incorporation or Organization)</I></FONT></TD>
      <TD STYLE="text-align: center">&nbsp;</TD>
      <TD STYLE="text-align: center"><I>Identification Number)</I></TD></TR>
    <TR STYLE="vertical-align: top">
      <TD STYLE="text-align: center">&nbsp;</TD>
      <TD STYLE="text-align: center">&nbsp;</TD>
      <TD STYLE="text-align: center">&nbsp;</TD></TR>
    <TR STYLE="vertical-align: top">
      <TD STYLE="text-align: center"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt"><B>527 Madison Avenue</B></FONT></TD>
      <TD STYLE="text-align: center">&nbsp;</TD>
      <TD STYLE="text-align: center">&nbsp;</TD></TR>
    <TR STYLE="vertical-align: top">
      <TD STYLE="border-bottom: Black 1.5pt solid; text-align: center"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt"><B>New York, NY</B></FONT></TD>
      <TD STYLE="padding-bottom: 1.5pt; text-align: center">&nbsp;</TD>
      <TD STYLE="border-bottom: Black 1.5pt solid; text-align: center"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt"><B>10022</B></FONT></TD></TR>
    <TR STYLE="vertical-align: top">
      <TD STYLE="text-align: center"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt"><I>(Address of Principal Executive Offices)</I></FONT></TD>
      <TD STYLE="text-align: center">&nbsp;</TD>
      <TD STYLE="text-align: center"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt"><I>(Zip Code)</I></FONT></TD></TR>
    </TABLE>
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><I>&nbsp;</I></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><I></I></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><TABLE CELLSPACING="0" CELLPADDING="0" ALIGN="CENTER" STYLE="width: 100%; border-collapse: collapse"><TR STYLE="vertical-align: top"><TD COLSPAN="3" STYLE="font: bold 10pt Times New Roman, Times, Serif; text-align: center"><P STYLE="margin: 0pt 0; font: 10pt Times New Roman, Times, Serif"><B>Inducement
                                              Sign-On Restricted Stock Unit Grant Notice and Agreement</B></P></TD></TR>
  <TR STYLE="vertical-align: top">
  <TD COLSPAN="3" STYLE="font: bold 10pt Times New Roman, Times, Serif; text-align: center"><P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">Inducement Sign-On Option
  Grant Notice and&nbsp;Agreement</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 143.6pt 0pt 142.3pt; text-align: center"><I>(Full Title of the Plan)</I></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><I>&nbsp;</I></P></TD></TR>
  <TR STYLE="vertical-align: top">
      <TD STYLE="font: 10pt Times New Roman, Times, Serif; width: 34%; text-align: center">&nbsp;</TD>
      <TD STYLE="font: bold 10pt Times New Roman, Times, Serif; width: 33%; text-align: center">Barry W. Weiner<BR>
  President and Treasurer<BR>
  Enzo Biochem, Inc.<BR>
  527 Madison Avenue<BR>
  New York, NY 10022</TD>
      <TD STYLE="font: 10pt Times New Roman, Times, Serif; width: 33%; text-align: center">&nbsp;</TD></TR>
  <TR STYLE="vertical-align: top">
      <TD COLSPAN="3" STYLE="font: italic 10pt Times New Roman, Times, Serif; text-align: center">(Name and address of agent for service)</TD></TR>
  <TR STYLE="vertical-align: top">
      <TD COLSPAN="3" STYLE="font: italic 10pt Times New Roman, Times, Serif; text-align: center">&nbsp;</TD></TR>
  <TR STYLE="vertical-align: top">
      <TD COLSPAN="3" STYLE="font: italic 10pt Times New Roman, Times, Serif; text-align: center"><FONT STYLE="font-style: normal"><B>(212) 583-0100</B></FONT></TD></TR>
  <TR STYLE="vertical-align: top">
      <TD COLSPAN="3" STYLE="font: italic 10pt Times New Roman, Times, Serif; text-align: center">(Telephone number, including area code, of agent for service)</TD></TR>
  <TR STYLE="vertical-align: top">
      <TD COLSPAN="3" STYLE="font: italic 10pt Times New Roman, Times, Serif; text-align: center">&nbsp;</TD></TR>
  <TR STYLE="vertical-align: top">
      <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: center">&nbsp;</TD>
      <TD>
          <P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">Copy to:<BR>
          Robert H. Cohen, Esq.<BR>
          Ze&rsquo;-ev D. Eiger, Esq.<BR>
          McDermott Will&nbsp;&amp; Emery LLP<BR>
          340 Madison Avenue<BR>
          New York, NY 10173<BR>
          (212) 547-5400</P></TD></TR></TABLE>
  
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B>&nbsp;</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt">Indicate by check mark whether the registrant is a
  large accelerated filer, an accelerated filer, a non-accelerated filer, a smaller reporting company or an emerging growth company. See
  the definitions of &ldquo;large accelerated filer,&rdquo; &ldquo;accelerated filer,&rdquo; &ldquo;smaller reporting company&rdquo; and
  &ldquo;emerging growth company&rdquo; in Rule 12b-2 of the Exchange Act.</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt">&nbsp;</P>
  
  <TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
    <TR STYLE="vertical-align: top">
      <TD STYLE="width: 25%"><FONT STYLE="font-size: 10pt">Large accelerated filer </FONT></TD>
      <TD STYLE="width: 15%">&#9744;&nbsp;</TD>
      <TD STYLE="width: 20%">&nbsp;</TD>
      <TD STYLE="width: 25%"><FONT STYLE="font-size: 10pt">Accelerated filer </FONT></TD>
      <TD STYLE="width: 15%">&#9744;&nbsp;</TD></TR>
    <TR STYLE="vertical-align: top">
      <TD><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">Non-accelerated filer </FONT><FONT STYLE="font-family: Wingdings; font-size: 10pt"></FONT></TD>
      <TD><FONT STYLE="font-family: Wingdings 2"><FONT STYLE="font-family: Wingdings">&thorn;</FONT></FONT></TD>
      <TD>&nbsp;</TD>
      <TD><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">Smaller reporting company</FONT></TD>
      <TD><FONT STYLE="font-family: Wingdings 2"><FONT STYLE="font-family: Wingdings">&thorn;</FONT></FONT></TD></TR>
    <TR STYLE="vertical-align: top">
      <TD><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">Emerging growth company </FONT></TD>
      <TD>&#9744;</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD></TR>
    </TABLE>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt">If an emerging growth company, indicate by check
  mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting
  standards provided pursuant to Section 7(a)(2)(B) of the Exchange Act. <FONT STYLE="font-family: Times New Roman, Times, Serif">&#9744;</FONT></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"></P>
  
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  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 143pt 0pt 144.05pt; text-align: center"><B>CALCULATION OF REGISTRATION
  FEE</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B>&nbsp;</B></P>
  
  <TABLE CELLPADDING="0" CELLSPACING="0" STYLE="border-collapse: collapse; width: 100%; font: 9pt Times New Roman, Times, Serif">
    <TR STYLE="vertical-align: bottom">
      <TD STYLE="border-bottom: Black 1.5pt solid; text-align: left">Title of securities to be registered</TD><TD STYLE="text-align: center; padding-bottom: 1.5pt">&nbsp;</TD>
      <TD COLSPAN="2" STYLE="border-bottom: Black 1.5pt solid; text-align: center">Amount to be<BR> registered(1)(2)</TD><TD STYLE="text-align: center; padding-bottom: 1.5pt">&nbsp;</TD><TD STYLE="text-align: center; padding-bottom: 1.5pt">&nbsp;</TD>
      <TD COLSPAN="2" STYLE="border-bottom: Black 1.5pt solid; text-align: center">Proposed maximum <BR> offering price per share(3)</TD><TD STYLE="text-align: center; padding-bottom: 1.5pt">&nbsp;</TD><TD STYLE="text-align: center; padding-bottom: 1.5pt">&nbsp;</TD>
      <TD COLSPAN="2" STYLE="border-bottom: Black 1.5pt solid; text-align: center">Proposed maximum <BR> aggregate offering price(3)</TD><TD STYLE="text-align: center; padding-bottom: 1.5pt">&nbsp;</TD><TD STYLE="text-align: center; padding-bottom: 1.5pt">&nbsp;</TD>
      <TD COLSPAN="2" STYLE="border-bottom: Black 1.5pt solid; text-align: center">Amount of<BR> registration fee</TD><TD STYLE="text-align: center; padding-bottom: 1.5pt">&nbsp;</TD></TR>
    <TR STYLE="vertical-align: bottom; background-color: rgb(204,238,255)">
      <TD STYLE="width: 52%; text-align: left">Common Stock, par value $0.01 per share</TD><TD STYLE="width: 1%">&nbsp;</TD>
      <TD STYLE="width: 1%; text-align: left">&nbsp;</TD><TD STYLE="width: 9%; text-align: right">960,000</TD><TD STYLE="width: 1%; text-align: left">&nbsp;</TD><TD STYLE="width: 1%">&nbsp;</TD>
      <TD STYLE="width: 1%; text-align: left">$</TD><TD STYLE="width: 9%; text-align: right">3.40</TD><TD STYLE="width: 1%; text-align: left">&nbsp;</TD><TD STYLE="width: 1%">&nbsp;</TD>
      <TD STYLE="width: 1%; text-align: left">$</TD><TD STYLE="width: 9%; text-align: right">3,264,000</TD><TD STYLE="width: 1%; text-align: left">&nbsp;</TD><TD STYLE="width: 1%">&nbsp;</TD>
      <TD STYLE="width: 1%; text-align: left">$</TD><TD STYLE="width: 9%; text-align: right">302.57</TD><TD STYLE="width: 1%; text-align: left">&nbsp;</TD></TR>
    </TABLE>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 1.75pt 0pt 60.75pt; text-indent: -3.4pt"></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 1.75pt 0pt 60.75pt; text-indent: -3.4pt">&nbsp;</P>
  
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  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 1.75pt 0pt 60.75pt; text-indent: -3.4pt"></P>
  
  <TABLE CELLPADDING="0" CELLSPACING="0" STYLE="width: 100%; font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
  <TD STYLE="width: 0.25in">(1)</TD><TD>Represents the number of shares of common stock, $0.01 par value per share (&ldquo;Common Stock&rdquo;),
  of Enzo Biochem, Inc. (the &ldquo;Company&rdquo;), deliverable upon settlement of restricted stock units granted to Hamid Erfanian
  on November 8, 2021 pursuant to an Inducement  Restricted Stock Unit Grant Notice and Agreement between the Company and Mr. Erfanian
  (the &ldquo;Inducement RSU Award&rdquo;) and options   granted to Mr. Erfanian on November 8, 2021 pursuant to an Inducement
  Option Grant Notice and Agreement between the Company and Mr. Erfanian (the &ldquo;Inducement Option Award&rdquo;) being registered hereon.
  See &ldquo;Explanatory Note&rdquo; below.</TD></TR></TABLE>
  
  <TABLE CELLPADDING="0" CELLSPACING="0" STYLE="width: 100%; font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
  <TD STYLE="width: 0.25in">(2)</TD><TD>Pursuant to Rule 416(a) of the Securities Act of 1933, as amended (the &ldquo;Securities Act&rdquo;),
  this Registration Statement also registers any additional shares of Common Stock as may become deliverable pursuant to any anti-dilution
  provisions of the Inducement RSU Award and the Inducement Option Award, as applicable.</TD></TR></TABLE>
  
  <TABLE CELLPADDING="0" CELLSPACING="0" STYLE="width: 100%; font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
  <TD STYLE="width: 0.25in">(3)</TD><TD>Estimated solely for the purpose of determining the amount of the registration fee pursuant to Rule
  457(c) and Rule 457(h) under the Securities Act, based on the average of the high and low prices per share of Common Stock as reported
  on the New York Stock Exchange on November 3, 2021.</TD></TR></TABLE>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 37pt; text-indent: 0in">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 37pt; text-indent: 0in"></P>
  
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  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 37pt; text-indent: 0in">&nbsp;</P>
  
  
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  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>
  
  <P STYLE="margin: 0pt 0; font: 10pt Times New Roman, Times, Serif"></P>
  
  <P STYLE="text-align: center; margin-top: 0pt; margin-bottom: 0pt"><B><U>Explanatory Note</U></B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B>&nbsp;</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Pursuant to the Inducement RSU Award and the Inducement Option
  Award, the Company granted restricted stock units covering 260,000 shares of Common Stock and options covering 700,000 shares of Common
  Stock on November 8, 2021. This Registration Statement registers the Common Stock issuable upon settlement of such grants.</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">The foregoing grants are material inducements to Mr. Erfanian&rsquo;s
  acceptance of employment as the Chief Executive Officer of the Company, and were approved by the Compensation Committee of the Company&rsquo;s
  Board of Directors. Such grants are in reliance on Section 303A.08 of the New York Stock Exchange (&ldquo;NYSE&rdquo;) Listed Company
  Manual, which exempts certain inducement equity grants from the general requirement of the NYSE rules that equity-based compensation plans
  and arrangements be approved by stockholders.</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"></P>
  
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  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
  
  <P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center">PART II</P>
  
  <P STYLE="text-align: center; font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><B>INFORMATION REQUIRED IN
  THE REGISTRATION STATEMENT</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0"><B>&nbsp;</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0"><B>ITEM 3. INCORPORATION OF DOCUMENTS BY REFERENCE.</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin-left: 0.5in; margin-top: 0pt; margin-bottom: 0pt">The following documents filed with the Commission are hereby
  incorporated by reference into this Registration Statement:</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt">&nbsp;</P>
  
  <TABLE CELLPADDING="0" CELLSPACING="0" STYLE="width: 100%; font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
  <TD STYLE="width: 0.5in"></TD><TD STYLE="width: 0.25in">(a)</TD><TD STYLE="padding-right: 9.95pt">the Company&rsquo;s Annual Report on <A HREF="http://www.sec.gov/Archives/edgar/data/316253/000121390021052364/f10k2021_enzobio.htm">Form 10-K</A> for the year ended July 31, 2021, filed with the Commission
  on October 12, 2021;</TD></TR></TABLE>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt">&nbsp;</P>
  
  <TABLE CELLPADDING="0" CELLSPACING="0" STYLE="width: 100%; font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
  <TD STYLE="width: 0.5in"></TD><TD STYLE="width: 0.25in">(b)</TD><TD STYLE="padding-right: 32.5pt">the Company&rsquo;s Current Report on <A HREF="http://www.sec.gov/Archives/edgar/data/316253/000121390021053147/ea148999-8k_enzobiochem.htm">Form 8-K</A> filed with the Commission on October 18, 2021; and</TD></TR></TABLE>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt">&nbsp;</P>
  
  <TABLE CELLPADDING="0" CELLSPACING="0" STYLE="width: 100%; font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
  <TD STYLE="width: 0.5in"></TD><TD STYLE="width: 0.25in">(c)</TD><TD STYLE="padding-right: 37.45pt">the description of the Common Stock set forth in the Company&rsquo;s Registration Statement on <A HREF="http://www.sec.gov/Archives/edgar/data/316253/000100547799005756/0001005477-99-005756.txt">Form 8-A</A>, filed with the Commission on December 8, 1999.</TD></TR></TABLE>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-indent: 29.15pt">All documents filed by the Company
  pursuant to Section 13(a), 13(c), 14 or 15(d) of the Securities Exchange Act of 1934, as amended, subsequent to the date hereof and prior
  to the filing of a post-effective amendment which indicates that all securities offered have been sold or which deregisters all securities
  then remaining unsold shall be deemed to be incorporated by reference herein and to be a part hereof from the date of filing of such documents.</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-indent: 29.15pt">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-indent: 29.15pt">Notwithstanding the foregoing, unless specifically
  stated to the contrary, none of the information disclosed by the Company under Items 2.02 or 7.01 of any Current Report on Form 8-K that
  the Company may from time to time furnish to the Commission will be incorporated by reference into, or otherwise included in, this Registration
  Statement. Any statement contained herein or in a document incorporated or deemed to be incorporated by reference herein shall be deemed
  to be modified or superseded for purposes of this Registration Statement to the extent that a statement contained herein or in any subsequently
  filed document which also is or is deemed to be incorporated by reference herein modifies or supersedes such statement. Any such statement
  so modified or superseded shall not be deemed, except as so modified or superseded, to constitute a part of this Registration Statement.</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt">&nbsp;</P>
  
  
  <!-- Field: Page; Sequence: 4; Options: NewSection -->
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  <P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center">&nbsp;</P>
  
  <P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center">EXHIBIT INDEX</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt">&nbsp;</P>
  
  <TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
    <TR STYLE="vertical-align: top">
      <TD STYLE="border-bottom: Black 1.5pt solid; width: 10%"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">No.</FONT></TD>
      <TD STYLE="padding-bottom: 1.5pt; width: 1%">&nbsp;</TD>
      <TD STYLE="border-bottom: Black 1.5pt solid; width: 89%"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">Description</FONT></TD></TR>
    <TR STYLE="vertical-align: top; background-color: rgb(204,238,255)">
      <TD><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">4.1</FONT></TD>
      <TD>&nbsp;</TD>
      <TD><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt"><A HREF="http://www.sec.gov/Archives/edgar/data/316253/000093041305002352/c36807_ex4-1.txt">Certificate of Incorporation.(1)</A></FONT></TD></TR>
    <TR STYLE="vertical-align: top; background-color: White">
      <TD><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">4.2</FONT></TD>
      <TD>&nbsp;</TD>
      <TD><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt"><A HREF="http://www.sec.gov/Archives/edgar/data/316253/000093041305002352/c36807_ex4-2.txt">Certificate of Amendment of the Certificate of Incorporation, Filed March 17, 1980.(1)</A></FONT></TD></TR>
    <TR STYLE="vertical-align: top; background-color: rgb(204,238,255)">
      <TD><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">4.3</FONT></TD>
      <TD>&nbsp;</TD>
      <TD><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt"><A HREF="http://www.sec.gov/Archives/edgar/data/316253/000093041305002352/c36807_ex4-3.txt">Certificate of Amendment of the Certificate of Incorporation, Filed June 16, 1981.(1)</A></FONT></TD></TR>
    <TR STYLE="vertical-align: top; background-color: White">
      <TD><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">4.4</FONT></TD>
      <TD>&nbsp;</TD>
      <TD><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt"><A HREF="http://www.sec.gov/Archives/edgar/data/316253/000093041305002352/c36807_ex4-4.txt">Certificate of Amendment to the Certificate of Incorporation, Filed July 22, 1988.(1)</A></FONT></TD></TR>
    <TR STYLE="vertical-align: top; background-color: rgb(204,238,255)">
      <TD><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">4.5</FONT></TD>
      <TD>&nbsp;</TD>
      <TD><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt"><A HREF="http://www.sec.gov/Archives/edgar/data/316253/000093041313000254/c72341_ex3-ii.htm">Amended and Restated By-Laws.(2)</A></FONT></TD></TR>
    <TR STYLE="vertical-align: top; background-color: White">
      <TD><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">4.6</FONT></TD>
      <TD>&nbsp;</TD>
      <TD><A HREF="http://www.sec.gov/Archives/edgar/data/0000316253/000093041318003408/c92357_ex3-1.htm"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">Amended and Restated By-Laws.(3)</FONT></A></TD></TR>
    <TR STYLE="vertical-align: top; background-color: rgb(204,238,255)">
      <TD><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">4.7</FONT></TD>
      <TD>&nbsp;</TD>
      <TD><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt"><A HREF="http://www.sec.gov/Archives/edgar/data/316253/000093041320000690/c95361_ex3-1.htm">Amendment No. 1 to Amended and Restated By-Laws.(4)</A></FONT></TD></TR>
    <TR STYLE="vertical-align: top; background-color: White">
      <TD><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">4.8</FONT></TD>
      <TD>&nbsp;</TD>
      <TD><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt"><A HREF="http://www.sec.gov/Archives/edgar/data/316253/000093041305002352/c36807_ex4-6.txt">Form of Common Stock Certificate.(1)</A></FONT></TD></TR>
    <TR STYLE="vertical-align: top; background-color: rgb(204,238,255)">
      <TD><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">5.1&nbsp;&nbsp;</FONT></TD>
      <TD>&nbsp;</TD>
      <TD><A HREF="ea150009ex5-1_enzobio.htm"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">Legal Opinion of McDermott Will &amp; Emery LLP.</FONT></A></TD></TR>
    <TR STYLE="vertical-align: top; background-color: White">
      <TD><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">23.1</FONT></TD>
      <TD>&nbsp;</TD>
      <TD><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt"><A HREF="ea150009ex23-1_enzobio.htm">Consent of EisnerAmper LLP.</A></FONT></TD></TR>
    <TR STYLE="vertical-align: top; background-color: rgb(204,238,255)">
      <TD><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">23.2</FONT></TD>
      <TD>&nbsp;</TD>
      <TD><A HREF="ea150009ex5-1_enzobio.htm"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">Consent of McDermott Will &amp; Emery LLP (included in exhibit 5.1).</FONT></A></TD></TR>
    <TR STYLE="vertical-align: top; background-color: White">
      <TD><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">24.1 </FONT></TD>
      <TD>&nbsp;</TD>
      <TD><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt"><A HREF="#a_001">Powers of Attorney of the directors and certain officers of the Company (included on the signature page to the Registration Statement).</A></FONT></TD></TR>
    <TR STYLE="vertical-align: top; background-color: rgb(204,238,255)">
      <TD><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">99.1</FONT></TD>
      <TD>&nbsp;</TD>
      <TD><A HREF="ea150009ex99-1_enzobio.htm"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">Inducement  Restricted Stock Unit Grant Notice and Agreement</FONT></A></TD></TR>
    <TR STYLE="vertical-align: top; background-color: White">
      <TD><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">99.2</FONT></TD>
      <TD>&nbsp;</TD>
      <TD><A HREF="ea150009ex99-2_enzobio.htm"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">Inducement  Option Grant Notice and Agreement</FONT></A></TD></TR>
    </TABLE>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt">&nbsp;</P>
  
  <!-- Field: Rule-Page --><DIV STYLE="margin-top: 0; margin-bottom: 0; width: 25%"><DIV STYLE="font-size: 1pt; border-top: Black 1.5pt solid">&nbsp;</DIV></DIV><!-- Field: /Rule-Page -->
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"></P>
  
  <TABLE CELLPADDING="0" CELLSPACING="0" STYLE="width: 100%; font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
  <TD STYLE="width: 0.25in">(1)</TD><TD STYLE="padding-right: 15.7pt">Incorporated by reference from the Company&rsquo;s Registration Statement on Form S-8 (Registration
  No. 333-123712) filed with the Commission on March 31, 2005.</TD></TR></TABLE>
  
  <TABLE CELLPADDING="0" CELLSPACING="0" STYLE="width: 100%; font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
  <TD STYLE="width: 0.25in">(2)</TD><TD>Incorporated by reference from the Company&rsquo;s Current Report on Form 8-K filed with the Commission on January 22, 2013.</TD></TR></TABLE>
  
  <TABLE CELLPADDING="0" CELLSPACING="0" STYLE="width: 100%; font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
  <TD STYLE="width: 0.25in">(3)</TD><TD>Incorporated by reference from the Company&rsquo;s Current Report on Form 8-K filed with the Commission on November 21, 2018.</TD></TR></TABLE>
  
  <TABLE CELLPADDING="0" CELLSPACING="0" STYLE="width: 100%; font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
  <TD STYLE="width: 0.25in">(4)</TD><TD>Incorporated by reference from the Company&rsquo;s Current Report on Form 8-K filed with the Commission on March 2, 2020.</TD></TR></TABLE>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt">&nbsp;</P>
  
  
  <!-- Field: Page; Sequence: 5 -->
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      <DIV STYLE="break-before: page; margin-top: 6pt; margin-bottom: 12pt"><P STYLE="margin: 0pt">&nbsp;</P></DIV>
      <!-- Field: /Page -->
  
  <P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: left">&nbsp;</P>
  
  <P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center">SIGNATURES</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><B>&nbsp;</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-indent: 29.15pt">Pursuant to the requirements
  of the Securities Act of 1933, the Company certifies that it has reasonable grounds to believe that it meets all of the requirements for
  filing on Form S-8 and has duly caused this Registration Statement to be signed on its behalf by the undersigned, thereunto duly authorized,
  in the City of New York, State of New York, on November 9, 2021.</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt">&nbsp;</P>
  
  <TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
    <TR STYLE="vertical-align: top">
      <TD>&nbsp;</TD>
      <TD COLSPAN="2"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">ENZO BIOCHEM, INC.</FONT></TD></TR>
    <TR STYLE="vertical-align: top">
      <TD>&nbsp;</TD>
      <TD COLSPAN="2">&nbsp;</TD></TR>
    <TR STYLE="vertical-align: top">
      <TD STYLE="width: 60%">&nbsp;</TD>
      <TD STYLE="width: 4%"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">By:</FONT></TD>
      <TD STYLE="border-bottom: Black 1.5pt solid; width: 36%"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">/s/ Hamid Erfanian</FONT></TD></TR>
    <TR STYLE="vertical-align: top">
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">Hamid Erfanian</FONT></TD></TR>
    <TR STYLE="vertical-align: top">
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">Chief Executive Officer</FONT></TD></TR>
    </TABLE>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt">&nbsp;&nbsp;</P>
  
  <P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center"><A NAME="a_001"></A>POWER OF ATTORNEY</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><B>&nbsp;</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-indent: 29.15pt">KNOW ALL PERSONS BY THESE PRESENT,
  that each person whose signature appears below constitutes and appoints Hamid Erfanian and David Bench, and each or either of them,
  his true and lawful attorney-in-fact and agent, with full power of substitution and resubstitution, for him and in his name, place and
  stead, in any and all capacities, to sign any and all amendments, including post-effective amendments, to this Registration Statement,
  and to file the same, with all exhibits thereto, and other documents in connection therewith, with the Securities and Exchange Commission,
  granting unto said attorneys-in-fact and agents, and each of them, full power and authority to do and perform each and every act and thing
  requisite and necessary to be done in connection therewith, as fully to all intents and purposes as he might or could do in person, hereby
  ratifying and confirming all that said attorneys-in-fact and agents, or any of them, or their or his substitutes or substitute, may lawfully
  do or cause to be done by virtue hereof.</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-indent: 29.15pt">Pursuant to the requirements
  of the Securities Act of 1933, this Registration Statement has been signed below by the following persons in the capacities and on the
  dates indicated.</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt">&nbsp;<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
  <TR STYLE="vertical-align: top"><TD STYLE="width: 60%"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">Date: November 9, 2021</FONT></TD>
      <TD STYLE="width: 4%"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">By:</FONT></TD>
      <TD STYLE="border-bottom: Black 1.5pt solid; width: 36%"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">/s/ Hamid Erfanian</FONT></TD></TR>
    <TR STYLE="vertical-align: top">
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">Hamid Erfanian</FONT></TD></TR>
    <TR STYLE="vertical-align: top">
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD>Chief Executive Officer <BR>
  (Principal Executive Officer)</TD></TR>
    <TR STYLE="vertical-align: top">
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD></TR>
    <TR STYLE="vertical-align: top">
      <TD><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">Date: November 9, 2021</FONT></TD>
      <TD><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">By:</FONT></TD>
      <TD STYLE="border-bottom: Black 1.5pt solid"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">/s/ David Bench</FONT></TD></TR>
    <TR STYLE="vertical-align: top">
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">David Bench</FONT></TD></TR>
    <TR STYLE="vertical-align: top">
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">Chief Financial Officer</FONT></TD></TR>
    <TR STYLE="vertical-align: top">
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">(Principal Financial Officer and Principal Accounting Officer)</FONT></TD></TR>
    <TR STYLE="vertical-align: top">
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD></TR>
    <TR STYLE="vertical-align: top">
      <TD><FONT STYLE="font: 10pt Times New Roman, Times, Serif">Date: November 9, 2021</TD>
      <TD><FONT STYLE="font: 10pt Times New Roman, Times, Serif">By:</TD>
      <TD STYLE="border-bottom: Black 1.5pt solid"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">/s/ Barry W. Weiner</TD></TR>
    <TR STYLE="vertical-align: top">
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD><FONT STYLE="font: 10pt Times New Roman, Times, Serif">Barry W. Weiner </FONT></TD></TR>
    <TR STYLE="vertical-align: top">
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD><FONT STYLE="font: 10pt Times New Roman, Times, Serif">President and Treasurer</FONT></TD></TR>
    <TR STYLE="vertical-align: top">
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD></TR>
    <TR STYLE="vertical-align: top">
      <TD>Date: November 9, 2021</TD>
      <TD><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">By:</FONT></TD>
      <TD STYLE="border-bottom: Black 1.5pt solid"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">/s/ Elazar Rabbani, Ph.D.</FONT></TD></TR>
    <TR STYLE="vertical-align: top">
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD>Elazar Rabbani, Ph.D.</TD></TR>
    <TR STYLE="vertical-align: top">
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD>Chairman of the Board and Director</TD></TR>
    <TR STYLE="vertical-align: top">
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD></TR>
    <TR STYLE="vertical-align: top">
      <TD><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">Date: November 9, 2021</FONT></TD>
      <TD><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">By:</FONT></TD>
      <TD STYLE="border-bottom: Black 1.5pt solid"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">/s/ Rebecca J. Fischer</FONT></TD></TR>
    <TR STYLE="vertical-align: top">
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">Rebecca J. Fischer </FONT></TD></TR>
    <TR STYLE="vertical-align: top">
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">Director</FONT></TD></TR>
    <TR STYLE="vertical-align: top">
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD></TR>
    <TR STYLE="vertical-align: top">
      <TD><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">Date: November 9, 2021</FONT></TD>
      <TD><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">By:</FONT></TD>
      <TD STYLE="border-bottom: Black 1.5pt solid"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">/s/ Dov Perlysky</FONT></TD></TR>
    <TR STYLE="vertical-align: top">
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">Dov Perlysky </FONT></TD></TR>
    <TR STYLE="vertical-align: top">
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">Director</FONT></TD></TR>
    <TR STYLE="vertical-align: top">
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD></TR>
    <TR STYLE="vertical-align: top">
      <TD><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">Date: November 9, 2021</FONT></TD>
      <TD><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">By:</FONT></TD>
      <TD STYLE="border-bottom: Black 1.5pt solid"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">/s/ Mary Tagliaferri</FONT></TD></TR>
    <TR STYLE="vertical-align: top">
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">Mary Tagliaferri&nbsp;</FONT></TD></TR>
    <TR STYLE="vertical-align: top">
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">Director</FONT></TD></TR>
    <TR STYLE="vertical-align: top">
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD></TR>
    <TR STYLE="vertical-align: top">
      <TD><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">Date: November 9, 2021</FONT></TD>
      <TD><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">By:</FONT></TD>
      <TD STYLE="border-bottom: Black 1.5pt solid"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">/s/ Ian B. Walters</FONT></TD></TR>
    <TR STYLE="vertical-align: top">
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">Ian B. Walters</FONT></TD></TR>
    <TR STYLE="vertical-align: top">
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">Director</FONT></TD></TR>
    </TABLE>
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metadata_documents: [{"type": "S-8", "sequence": "1", "filename": "ea150009-s8_enzobio.htm", "description": "REGISTRATION STATEMENT", "secsgml_size_bytes": 45571}]
metadata_filer: {"company-data": {"conformed-name": "ENZO BIOCHEM INC", "cik": "0000316253", "assigned-sic": "8071", "irs-number": "132866202", "state-of-incorporation": "NY", "fiscal-year-end": "0731"}, "filing-values": {"form-type": "S-8", "act": "33", "file-number": "333-260894", "film-number": "211390021"}, "business-address": {"street1": "60 EXECUTIVE BLVD", "city": "FARMINGDALE", "state": "NY", "zip": "11735", "phone": "5167555500"}, "mail-address": {"street1": "ENZO BIOCHEM INC", "street2": "60 EXECUTIVE BLVD", "city": "FARMINGDALE", "state": "NY", "zip": "11735"}}
text: As
  filed with the Securities and Exchange Commission on November 9, 2021
  Registration No. 333-
  UNITED STATES
  SECURITIES AND EXCHANGE COMMISSION
  Washington, D.C. 20549
  FORM S-8
  REGISTRATION
  STATEMENT
  UNDER
  THE SECURITIES ACT OF 1933
  ENZO BIOCHEM, INC.
  (Exact name of Registrant as specified
  in its charter)
  New York
  13-2866202
  (State or Other
      Jurisdiction of
  (I.R.S. Employer
  Incorporation or Organization)
  Identification Number)
  527 Madison Avenue
  New York, NY
  10022
  (Address of Principal Executive Offices)
  (Zip Code)
  Inducement
                                              Sign-On Restricted Stock Unit Grant Notice and Agreement
  Inducement Sign-On Option
  Grant Notice and Agreement
  (Full Title of the Plan)
  Barry W. Weiner
  President and Treasurer
  Enzo Biochem, Inc.
  527 Madison Avenue
  New York, NY 10022
  (Name and address of agent for service)
  (212) 583-0100
  (Telephone number, including area code, of agent for service)
  Copy to:
  Robert H. Cohen, Esq.
  Ze'-ev D. Eiger, Esq.
  McDermott Will & Emery LLP
  340 Madison Avenue
  New York, NY 10173
  (212) 547-5400
  Indicate by check mark whether the registrant is a
  large accelerated filer, an accelerated filer, a non-accelerated filer, a smaller reporting company or an emerging growth company. See
  the definitions of "large accelerated filer," "accelerated filer," "smaller reporting company" and
  "emerging growth company" in Rule 12b-2 of the Exchange Act.
  Large accelerated filer
  ☐
  Accelerated filer
  ☐
  Non-accelerated filer
  þ
  Smaller reporting company
  þ
  Emerging growth company
  ☐
  If an emerging growth company, indicate by check
  mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting
  standards provided pursuant to Section 7(a)(2)(B) of the Exchange Act.
  ☐
  CALCULATION OF REGISTRATION
  FEE
  Title of securities to be registered
  Amount to be
  registered(1)(2)
  Proposed maximum
  offering price per share(3)
  Proposed maximum
  aggregate offering price(3)
  Amount of
  registration fee
  Common Stock, par value $0.01 per share
  960,000
  $
  3.40
  $
  3,264,000
  $
  302.57
  (1)
  Represents the number of shares of common stock, $0.01 par value per share ("Common Stock"),
  of Enzo Biochem, Inc. (the "Company"), deliverable upon settlement of restricted stock units granted to Hamid Erfanian
  on November 8, 2021 pursuant to an Inducement  Restricted Stock Unit Grant Notice and Agreement between the Company and Mr. Erfanian
  (the "Inducement RSU Award") and options   granted to Mr. Erfanian on November 8, 2021 pursuant to an Inducement
  Option Grant Notice and Agreement between the Company and Mr. Erfanian (the "Inducement Option Award") being registered hereon.
  See "Explanatory Note" below.
  (2)
  Pursuant to Rule 416(a) of the Securities Act of 1933, as amended (the "Securities Act"),
  this Registration Statement also registers any additional shares of Common Stock as may become deliverable pursuant to any anti-dilution
  provisions of the Inducement RSU Award and the Inducement Option Award, as applicable.
  (3)
  Estimated solely for the purpose of determining the amount of the registration fee pursuant to Rule
  457(c) and Rule 457(h) under the Securities Act, based on the average of the high and low prices per share of Common Stock as reported
  on the New York Stock Exchange on November 3, 2021.
  Explanatory Note
  Pursuant to the Inducement RSU Award and the Inducement Option
  Award, the Company granted restricted stock units covering 260,000 shares of Common Stock and options covering 700,000 shares of Common
  Stock on November 8, 2021. This Registration Statement registers the Common Stock issuable upon settlement of such grants.
  The foregoing grants are material inducements to Mr. Erfanian's
  acceptance of employment as the Chief Executive Officer of the Company, and were approved by the Compensation Committee of the Company's
  Board of Directors. Such grants are in reliance on Section 303A.08 of the New York Stock Exchange ("NYSE") Listed Company
  Manual, which exempts certain inducement equity grants from the general requirement of the NYSE rules that equity-based compensation plans
  and arrangements be approved by stockholders.
  PART II
  INFORMATION REQUIRED IN
  THE REGISTRATION STATEMENT
  ITEM 3. INCORPORATION OF DOCUMENTS BY REFERENCE.
  The following documents filed with the Commission are hereby
  incorporated by reference into this Registration Statement:
  (a)
  the Company's Annual Report on
  Form 10-K
  for the year ended July 31, 2021, filed with the Commission
  on October 12, 2021;
  (b)
  the Company's Current Report on
  Form 8-K
  filed with the Commission on October 18, 2021; and
  (c)
  the description of the Common Stock set forth in the Company's Registration Statement on
  Form 8-A
  , filed with the Commission on December 8, 1999.
  All documents filed by the Company
  pursuant to Section 13(a), 13(c), 14 or 15(d) of the Securities Exchange Act of 1934, as amended, subsequent to the date hereof and prior
  to the filing of a post-effective amendment which indicates that all securities offered have been sold or which deregisters all securities
  then remaining unsold shall be deemed to be incorporated by reference herein and to be a part hereof from the date of filing of such documents.
  Notwithstanding the foregoing, unless specifically
  stated to the contrary, none of the information disclosed by the Company under Items 2.02 or 7.01 of any Current Report on Form 8-K that
  the Company may from time to time furnish to the Commission will be incorporated by reference into, or otherwise included in, this Registration
  Statement. Any statement contained herein or in a document incorporated or deemed to be incorporated by reference herein shall be deemed
  to be modified or superseded for purposes of this Registration Statement to the extent that a statement contained herein or in any subsequently
  filed document which also is or is deemed to be incorporated by reference herein modifies or supersedes such statement. Any such statement
  so modified or superseded shall not be deemed, except as so modified or superseded, to constitute a part of this Registration Statement.
  II-
  1
  EXHIBIT INDEX
  No.
  Description
  4.1
  Certificate of Incorporation.(1)
  4.2
  Certificate of Amendment of the Certificate of Incorporation, Filed March 17, 1980.(1)
  4.3
  Certificate of Amendment of the Certificate of Incorporation, Filed June 16, 1981.(1)
  4.4
  Certificate of Amendment to the Certificate of Incorporation, Filed July 22, 1988.(1)
  4.5
  Amended and Restated By-Laws.(2)
  4.6
  Amended and Restated By-Laws.(3)
  4.7
  Amendment No. 1 to Amended and Restated By-Laws.(4)
  4.8
  Form of Common Stock Certificate.(1)
  5.1
  Legal Opinion of McDermott Will & Emery LLP.
  23.1
  Consent of EisnerAmper LLP.
  23.2
  Consent of McDermott Will & Emery LLP (included in exhibit 5.1).
  24.1
  Powers of Attorney of the directors and certain officers of the Company (included on the signature page to the Registration Statement).
  99.1
  Inducement  Restricted Stock Unit Grant Notice and Agreement
  99.2
  Inducement  Option Grant Notice and Agreement
  (1)
  Incorporated by reference from the Company's Registration Statement on Form S-8 (Registration
  No. 333-123712) filed with the Commission on March 31, 2005.
  (2)
  Incorporated by reference from the Company's Current Report on Form 8-K filed with the Commission on January 22, 2013.
  (3)
  Incorporated by reference from the Company's Current Report on Form 8-K filed with the Commission on November 21, 2018.
  (4)
  Incorporated by reference from the Company's Current Report on Form 8-K filed with the Commission on March 2, 2020.
  II-
  2
  SIGNATURES
  Pursuant to the requirements
  of the Securities Act of 1933, the Company certifies that it has reasonable grounds to believe that it meets all of the requirements for
  filing on Form S-8 and has duly caused this Registration Statement to be signed on its behalf by the undersigned, thereunto duly authorized,
  in the City of New York, State of New York, on November 9, 2021.
  ENZO BIOCHEM, INC.
  By:
  /s/ Hamid Erfanian
  Hamid Erfanian
  Chief Executive Officer
  POWER OF ATTORNEY
  KNOW ALL PERSONS BY THESE PRESENT,
  that each person whose signature appears below constitutes and appoints Hamid Erfanian and David Bench, and each or either of them,
  his true and lawful attorney-in-fact and agent, with full power of substitution and resubstitution, for him and in his name, place and
  stead, in any and all capacities, to sign any and all amendments, including post-effective amendments, to this Registration Statement,
  and to file the same, with all exhibits thereto, and other documents in connection therewith, with the Securities and Exchange Commission,
  granting unto said attorneys-in-fact and agents, and each of them, full power and authority to do and perform each and every act and thing
  requisite and necessary to be done in connection therewith, as fully to all intents and purposes as he might or could do in person, hereby
  ratifying and confirming all that said attorneys-in-fact and agents, or any of them, or their or his substitutes or substitute, may lawfully
  do or cause to be done by virtue hereof.
  Pursuant to the requirements
  of the Securities Act of 1933, this Registration Statement has been signed below by the following persons in the capacities and on the
  dates indicated.
  Date: November 9, 2021
  By:
  /s/ Hamid Erfanian
  Hamid Erfanian
  Chief Executive Officer
  (Principal Executive Officer)
  Date: November 9, 2021
  By:
  /s/ David Bench
  David Bench
  Chief Financial Officer
  (Principal Financial Officer and Principal Accounting Officer)
  Date: November 9, 2021
  By:
  /s/ Barry W. Weiner
  Barry W. Weiner
  President and Treasurer
  Date: November 9, 2021
  By:
  /s/ Elazar Rabbani, Ph.D.
  Elazar Rabbani, Ph.D.
  Chairman of the Board and Director
  Date: November 9, 2021
  By:
  /s/ Rebecca J. Fischer
  Rebecca J. Fischer
  Director
  Date: November 9, 2021
  By:
  /s/ Dov Perlysky
  Dov Perlysky
  Director
  Date: November 9, 2021
  By:
  /s/ Mary Tagliaferri
  Mary Tagliaferri
  Director
  Date: November 9, 2021
  By:
  /s/ Ian B. Walters
  Ian B. Walters
  Director
  II-3