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  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>As filed with the Securities and Exchange Commission
  on October&nbsp;20, 2021 </B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: right"><B>Registration No.&nbsp;333-&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;
  </B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: right">&nbsp;</P>
  
  <!-- Field: Rule-Page --><DIV STYLE="margin-top: 1pt; margin-bottom: 1pt; width: 100%"><DIV STYLE="font-size: 1pt; border-top: black 0.75pt solid">&nbsp;</DIV></DIV><!-- Field: /Rule-Page -->
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>&nbsp;</B></P>
  
  <P STYLE="font: 18pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><FONT STYLE="font-size: 10pt"><B>UNITED STATES
  </B></FONT></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><FONT STYLE="font-size: 10pt"><B>SECURITIES AND
  EXCHANGE COMMISSION </B></FONT></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><FONT STYLE="font-size: 10pt"><B>Washington, D.C.
  20549</B></FONT></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>
  
  <!-- Field: Rule-Page --><DIV STYLE="margin-top: 1pt; margin-bottom: 1pt; width: 100%"><DIV STYLE="font-size: 1pt; border-top: black 1pt solid">&nbsp;</DIV></DIV><!-- Field: /Rule-Page -->
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>&nbsp;</B></P>
  
  <P STYLE="font: 18pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><FONT STYLE="font-size: 10pt"><B>FORM S-8 </B></FONT></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><FONT STYLE="font-size: 10pt"><B>REGISTRATION
  STATEMENT </B></FONT></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><FONT STYLE="font-size: 10pt"><B><I>UNDER </I></B></FONT></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><FONT STYLE="font-size: 10pt"><B><I>THE SECURITIES
  ACT OF 1933</I></B></FONT></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>
  
  <!-- Field: Rule-Page --><DIV STYLE="margin-top: 1pt; margin-bottom: 1pt; width: 100%"><DIV STYLE="font-size: 1pt; border-top: black 1pt solid">&nbsp;</DIV></DIV><!-- Field: /Rule-Page -->
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>&nbsp;</B></P>
  
  <P STYLE="font: 18pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>ARCTURUS THERAPEUTICS HOLDINGS INC. </B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>(Exact name of Registrant as specified in its
  charter) </B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>
  
  <!-- Field: Rule-Page --><DIV STYLE="margin-top: 1pt; margin-bottom: 1pt; width: 100%"><DIV STYLE="font-size: 1pt; border-top: black 1pt solid">&nbsp;</DIV></DIV><!-- Field: /Rule-Page -->
  
  <TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font-size: 10pt; width: 100%; border-collapse: collapse">
    <TR>
      <TD STYLE="width: 49%">&nbsp;</TD>
      <TD STYLE="vertical-align: bottom; width: 2%">&nbsp;</TD>
      <TD STYLE="width: 49%">&nbsp;</TD></TR>
    <TR>
      <TD STYLE="vertical-align: top; font-size: 10pt; text-align: center"><FONT STYLE="font-size: 10pt"><B>Delaware</B></FONT></TD>
      <TD STYLE="vertical-align: bottom; font-size: 10pt">&nbsp;</TD>
      <TD STYLE="vertical-align: top; font-size: 10pt; text-align: center"><FONT STYLE="font-size: 10pt"><B>32-0595345</B></FONT></TD></TR>
    <TR>
      <TD STYLE="vertical-align: top; font-size: 10pt; text-align: center"><FONT STYLE="font-size: 10pt"><B>(State or other jurisdiction of<BR>
  incorporation or organization)</B></FONT></TD>
      <TD STYLE="vertical-align: bottom; font-size: 10pt">&nbsp;</TD>
      <TD STYLE="vertical-align: top; font-size: 10pt; text-align: center"><FONT STYLE="font-size: 10pt"><B>(I.R.S. Employer<BR>
  Identification Number)</B></FONT></TD></TR>
    <TR>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD></TR>
    <TR>
      <TD STYLE="vertical-align: top">
      <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>10628 Science Center Drive, Suite 250 </B></P>
      <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>San Diego, California</B></P></TD>
      <TD STYLE="vertical-align: bottom; font-size: 10pt">&nbsp;</TD>
      <TD STYLE="vertical-align: bottom; font-size: 10pt; text-align: center"><FONT STYLE="font-size: 10pt"><B>92121</B></FONT></TD></TR>
    <TR>
      <TD STYLE="vertical-align: top; font-size: 10pt; text-align: center"><FONT STYLE="font-size: 10pt"><B>(Address of principal executive offices)</B></FONT></TD>
      <TD STYLE="vertical-align: bottom; font-size: 10pt">&nbsp;</TD>
      <TD STYLE="vertical-align: top; font-size: 10pt; text-align: center"><FONT STYLE="font-size: 10pt"><B>(Zip code)</B></FONT></TD></TR>
    </TABLE>
  
  <P STYLE="margin-top: 0; margin-bottom: 0">&nbsp;</P>
  <!-- Field: Rule-Page --><DIV STYLE="margin-top: 1pt; margin-bottom: 1pt; width: 100%"><DIV STYLE="font-size: 1pt; border-top: black 1pt solid">&nbsp;</DIV></DIV><!-- Field: /Rule-Page -->
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>&nbsp;</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>ARCTURUS THERAPEUTICS HOLDINGS INC. 2021 INDUCEMENT
  EQUITY INCENTIVE PLAN </B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>(Full title of the plan) </B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>Joseph E. Payne </B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>Chief Executive Officer </B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>Arcturus Therapeutics Holdings Inc. </B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>10628 Science Center Drive, Suite 250 </B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>San Diego, California 92121 </B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>(Name and address of agent for service) </B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>(858) 900-2660 </B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>(Telephone number, including area code, of agent
  for service) </B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>
  
  <!-- Field: Rule-Page --><DIV STYLE="margin-top: 1pt; margin-bottom: 1pt; width: 100%"><DIV STYLE="font-size: 1pt; border-top: black 1pt solid">&nbsp;</DIV></DIV><!-- Field: /Rule-Page -->
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><I>&nbsp;</I></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><I>Copies to: </I></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>Dentons US LLP </B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>1221 Avenue of the Americas </B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>New York, New York 10020 </B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>Jeffrey A. Baumel, Esq. </B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>Ilan Katz, Esq.</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>
  
  <!-- Field: Rule-Page --><DIV STYLE="margin-top: 1pt; margin-bottom: 1pt; width: 100%"><DIV STYLE="font-size: 1pt; border-top: black 1pt solid">&nbsp;</DIV></DIV><!-- Field: /Rule-Page -->
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Indicate by check mark whether the registrant is a large accelerated
  filer, an accelerated filer, a non-accelerated filer, a smaller reporting company, or an emerging growth company. See the definitions
  of &ldquo;large accelerated filer,&rdquo; &ldquo;accelerated filer,&rdquo; &ldquo;smaller reporting company,&rdquo; and &ldquo;emerging
  growth company&rdquo; in Rule 12b-2 of the Exchange Act. (Check one):</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
  
  <TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font-size: 10pt; width: 100%; border-collapse: collapse">
    <TR STYLE="vertical-align: bottom">
      <TD STYLE="font-size: 10pt; width: 19%"><FONT STYLE="font-size: 10pt">Large&nbsp;accelerated&nbsp;filer</FONT></TD>
      <TD STYLE="font-size: 10pt; width: 1%">&nbsp;</TD>
      <TD STYLE="font-size: 10pt; width: 54%"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#9746;</FONT></TD>
      <TD STYLE="font-size: 10pt; width: 1%">&nbsp;</TD>
      <TD STYLE="font-size: 10pt; width: 23%"><FONT STYLE="font-size: 10pt">Accelerated&nbsp;filer</FONT></TD>
      <TD STYLE="font-size: 10pt; width: 1%">&nbsp;</TD>
      <TD STYLE="font-size: 10pt; width: 1%"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#9744;</FONT></TD></TR>
    <TR>
      <TD>&nbsp;</TD>
      <TD COLSPAN="2">&nbsp;</TD>
      <TD COLSPAN="2">&nbsp;</TD>
      <TD COLSPAN="2">&nbsp;</TD></TR>
    <TR STYLE="vertical-align: bottom">
      <TD STYLE="font-size: 10pt"><FONT STYLE="font-size: 10pt">Non-accelerated filer</FONT></TD>
      <TD>&nbsp;</TD>
      <TD STYLE="font-size: 10pt"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#9744;</FONT></TD>
      <TD STYLE="font-size: 10pt">&nbsp;</TD>
      <TD STYLE="font-size: 10pt"><FONT STYLE="font-size: 10pt">Smaller&nbsp;reporting&nbsp;company</FONT></TD>
      <TD STYLE="font-size: 10pt">&nbsp;</TD>
      <TD STYLE="font-size: 10pt"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#9744;</FONT></TD></TR>
    <TR>
      <TD>&nbsp;</TD>
      <TD COLSPAN="2">&nbsp;</TD>
      <TD COLSPAN="2">&nbsp;</TD>
      <TD COLSPAN="2">&nbsp;</TD></TR>
    <TR STYLE="vertical-align: bottom">
      <TD>&nbsp;</TD>
      <TD STYLE="font-size: 10pt">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD STYLE="font-size: 10pt">&nbsp;</TD>
      <TD STYLE="font-size: 10pt"><FONT STYLE="font-size: 10pt">Emerging&nbsp;growth&nbsp;company</FONT></TD>
      <TD STYLE="font-size: 10pt">&nbsp;</TD>
      <TD STYLE="font-size: 10pt"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#9744;</FONT></TD></TR>
    </TABLE>
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">If an emerging growth company, indicate by check mark if the registrant
  has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant
  to Section&nbsp;7(a)(2)(B) of the Securities Act&nbsp;&nbsp;<FONT STYLE="font-family: Times New Roman, Times, Serif">&#9744;</FONT></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
  
  <!-- Field: Rule-Page --><DIV STYLE="margin-top: 1pt; margin-bottom: 1pt; width: 100%"><DIV STYLE="font-size: 1pt; border-top: black 1pt solid">&nbsp;</DIV></DIV><!-- Field: /Rule-Page -->
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>&nbsp;</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>CALCULATION OF REGISTRATION FEE </B></P>
  
  <TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font-size: 10pt; width: 100%; border-collapse: collapse">
    <TR>
      <TD STYLE="width: 44%">&nbsp;</TD>
      <TD STYLE="vertical-align: bottom; width: 1%">&nbsp;</TD>
      <TD STYLE="width: 13%">&nbsp;</TD>
      <TD STYLE="vertical-align: bottom; width: 1%">&nbsp;</TD>
      <TD STYLE="width: 13%">&nbsp;</TD>
      <TD STYLE="vertical-align: bottom; width: 1%">&nbsp;</TD>
      <TD STYLE="width: 13%">&nbsp;</TD>
      <TD STYLE="vertical-align: bottom; width: 1%">&nbsp;</TD>
      <TD STYLE="width: 13%">&nbsp;</TD></TR>
    <TR STYLE="vertical-align: bottom">
      <TD STYLE="border-top: black 1pt solid; font-size: 10pt; text-align: center"><FONT STYLE="font-size: 10pt"><B>Title of Securities<BR>
  to be Registered</B></FONT></TD>
      <TD STYLE="border-top: black 1pt solid; border-left: black 1pt solid; font-size: 10pt">&nbsp;</TD>
      <TD STYLE="white-space: nowrap; border-top: black 1pt solid; font-size: 10pt; text-align: center"><FONT STYLE="font-size: 10pt"><B>Amount<BR>
  to be<BR>
  Registered(1)</B></FONT></TD>
      <TD STYLE="border-top: black 1pt solid; border-left: black 1pt solid; font-size: 10pt">&nbsp;</TD>
      <TD STYLE="white-space: nowrap; border-top: black 1pt solid; font-size: 10pt; text-align: center"><FONT STYLE="font-size: 10pt"><B>Proposed<BR>
  Maximum<BR>
  Offering&nbsp;Price<BR>
  Per Share</B></FONT></TD>
      <TD STYLE="border-top: black 1pt solid; border-left: black 1pt solid; font-size: 10pt">&nbsp;</TD>
      <TD STYLE="white-space: nowrap; border-top: black 1pt solid; font-size: 10pt; text-align: center"><FONT STYLE="font-size: 10pt"><B>Proposed<BR>
  Maximum<BR>
  Aggregate<BR>
  Offering&nbsp;Price</B></FONT></TD>
      <TD STYLE="border-top: black 1pt solid; border-left: black 1pt solid; font-size: 10pt">&nbsp;</TD>
      <TD STYLE="white-space: nowrap; border-top: black 1pt solid; font-size: 10pt; text-align: center"><FONT STYLE="font-size: 10pt"><B>Amount of<BR>
  Registration&nbsp;Fee</B></FONT></TD></TR>
    <TR>
      <TD STYLE="vertical-align: top; border-top: black 1pt solid; padding-left: 10pt; font-size: 10pt; text-indent: -10pt"><FONT STYLE="font-size: 10pt">Common Stock (par value $0.001) reserved for issuance under the Arcturus Therapeutics Holdings Inc. 2021 Inducement Equity Incentive Plan</FONT></TD>
      <TD STYLE="vertical-align: bottom; border-top: black 1pt solid; border-left: black 1pt solid; font-size: 10pt">&nbsp;</TD>
      <TD STYLE="white-space: nowrap; vertical-align: bottom; border-top: black 1pt solid; font-size: 10pt; text-align: center"><FONT STYLE="font-size: 10pt">1,000,000</FONT></TD>
      <TD STYLE="vertical-align: bottom; border-top: black 1pt solid; border-left: black 1pt solid; font-size: 10pt">&nbsp;</TD>
      <TD STYLE="white-space: nowrap; vertical-align: bottom; border-top: black 1pt solid; font-size: 10pt; text-align: center"><FONT STYLE="font-size: 10pt">$45.17 (2)</FONT></TD>
      <TD STYLE="vertical-align: bottom; border-top: black 1pt solid; border-left: black 1pt solid; font-size: 10pt">&nbsp;</TD>
      <TD STYLE="white-space: nowrap; vertical-align: bottom; border-top: black 1pt solid; font-size: 10pt; text-align: center"><FONT STYLE="font-size: 10pt">$45,170,000</FONT></TD>
      <TD STYLE="vertical-align: bottom; border-top: black 1pt solid; border-left: black 1pt solid; font-size: 10pt">&nbsp;</TD>
      <TD STYLE="white-space: nowrap; vertical-align: bottom; border-top: black 1pt solid; font-size: 10pt; text-align: center"><FONT STYLE="font-size: 10pt">$4,187.26 (3)</FONT></TD></TR>
    </TABLE>
  <TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font-size: 10pt; width: 100%; border-collapse: collapse">
    <TR STYLE="vertical-align: top">
      <TD STYLE="width: 4%; font-size: 10pt"><FONT STYLE="font-size: 10pt">(1)</FONT></TD>
      <TD STYLE="font-size: 10pt"><FONT STYLE="font-size: 10pt">Pursuant to Rule 416(a) of the Securities Act of 1933, as amended (the &ldquo;Securities Act&rdquo;), this registration statement (the &ldquo;Registration Statement&rdquo;) shall also cover any additional shares of Common Stock of Arcturus Therapeutics Holdings Inc. &nbsp;(the &ldquo;Registrant&rdquo;) that become issuable in respect of the securities identified in the above table by reason of any stock dividend, stock split, recapitalization or other similar transaction effected without the receipt of consideration that increases the number of outstanding shares of the Registrant&rsquo;s Common Stock. </FONT></TD></TR>
    </TABLE>
  <TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font-size: 10pt; width: 100%; border-collapse: collapse">
    <TR STYLE="vertical-align: top">
      <TD STYLE="width: 4%; font-size: 10pt"><FONT STYLE="font-size: 10pt">(2)</FONT></TD>
      <TD STYLE="font-size: 10pt"><FONT STYLE="font-size: 10pt">Estimated solely for the purpose of calculating the registration fee in accordance with Rules 457(c) and 457(h) under the Securities Act on the basis of the average of the reported high and low sales prices for the Registrant&rsquo;s common stock as reported by the Nasdaq Global Market on October&nbsp;19, 2021. </FONT></TD></TR>
    </TABLE>
  <TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font-size: 10pt; width: 100%; border-collapse: collapse">
    <TR STYLE="vertical-align: top">
      <TD STYLE="width: 4%; font-size: 10pt"><FONT STYLE="font-size: 10pt">(3)</FONT></TD>
      <TD STYLE="font-size: 10pt"><FONT STYLE="font-size: 10pt">The amount of the registration fee is calculated pursuant to Section&nbsp;6(b) of the Securities Act, which currently provides that the filing fee rate shall be &ldquo;$92.70 per $1 million&rdquo; of the maximum aggregate price at which such securities are proposed to be offered. The Registration Fee is therefore calculated by multiplying the Proposed Maximum Aggregate Offering Price by 0.0000927. </FONT></TD></TR>
    </TABLE>
  
  <P STYLE="margin-top: 0; margin-bottom: 0">&nbsp;</P>
  
  <P STYLE="margin-top: 0; margin-bottom: 0"></P>
  
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  <P STYLE="margin-top: 0; margin-bottom: 0">&nbsp;</P>
  
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>PART I </B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>INFORMATION REQUIRED IN THE SECTION 10(a) PROSPECTUS
  </B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B>Item&nbsp;1. Plan Information </B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">The documents containing the information specified in this Item 1 will
  be sent or given to participants as specified by Rule&nbsp;428(b)(1) under the Securities Act. In accordance with the rules and regulations
  of the Securities and Exchange Commission (the &ldquo;Commission&rdquo;) and the instructions to Form S-8, such documents are not being
  filed with the Commission either as part of this Registration Statement or as prospectuses or prospectus supplements pursuant to Rule&nbsp;424
  under the Securities Act.</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B>Item&nbsp;2. Registration Information and Employee Plan Annual Information
  </B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">The documents containing the information specified in this Item 2
  will be sent or given to participants as specified by Rule&nbsp;428(b)(1) under the Securities Act. In accordance with the rules and
  regulations of the Commission and the instructions to Form S-8, such documents are not being filed with the Commission either as part
  of this Registration Statement or as prospectuses or prospectus supplements pursuant to Rule&nbsp;424 under the Securities Act. Such
  documents, together with the documents incorporated by reference herein pursuant to Item 3 of Part&nbsp;II of this Registration Statement
  on Form S-8, constitute a prospectus that meets the requirements of Section&nbsp;10(a) of the Securities Act, and are available upon
  written or oral request to: Arcturus Therapeutics Holdings Inc., Attn: Chief Financial Officer, Arcturus Therapeutics Holdings Inc.,
  10628 Science Center Drive, Suite 250, San Diego, California 92121, Tel: (858) 900-2660.</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>PART II </B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>INFORMATION REQUIRED IN THE REGISTRATION STATEMENT
  </B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B>Item&nbsp;3. Incorporation of Documents by Reference </B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">The Registrant hereby incorporates by reference into this Registration
  Statement the following documents previously filed with the Commission (other than information in a report on Form 8-K that is furnished
  and not filed pursuant to Form 8-K and, except as may be noted in any such Form 8-K, exhibits filed on such form that are related to such
  information):</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">(i) The Registrant&rsquo;s Annual Report on <FONT><U STYLE="text-decoration: none">Form
  10-K</U></FONT> for the fiscal year ended December&nbsp;31, 2020, filed with the Commission on March&nbsp; 1, 2021, including the information
  specifically incorporated by reference therein from our Definitive Proxy Statement on <FONT><U STYLE="text-decoration: none">Schedule 14A</U></FONT>
  filed with the Commission on April&nbsp;30, 2021, pursuant to Section&nbsp;13 of the Securities Exchange Act of 1934, as amended (the
  &ldquo;1934 Act&rdquo;);</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">(ii) The Registrant&rsquo;s Quarterly Report on <FONT><U STYLE="text-decoration: none">Form
  10-Q</U></FONT> for the periods ended March&nbsp;31, 2021 and June 30, 2021, filed with the Commission on May&nbsp;10, 2021 and August
  10, 2021;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">(iii) The Registrant&rsquo;s Current Reports on Form 8-K filed with
  the Commission pursuant to Section&nbsp;13 of the 1934 Act on February&nbsp;3, 2021, February&nbsp;22, 2021, <FONT>March&nbsp;1,
  2021</FONT>, <FONT>April&nbsp;26, 2021</FONT>, <FONT>May 10, 2021</FONT>, <FONT>June&nbsp;22,
  2021</FONT>, <FONT>August&nbsp;4, 2021</FONT>, <FONT>August 9, 2021</FONT>, <FONT>August
  26</FONT>, <FONT>2021</FONT> and <FONT>October 5, 2021</FONT>; and</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">(iii) The description of the Registrant&rsquo;s common stock set forth
  in the registration statement on Form 8-A registering the Registrant&rsquo;s common stock under Section 12 of the Exchange Act, as filed
  with the SEC on May 17, 2013, including any amendments or reports filed for purposes of updating such description, including the Form
  8-K12B filed on June 14, 2019.</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">All documents filed by the Registrant pursuant to Section&nbsp;13(a),
  13(c), 14 or 15(d) of the 1934 Act after the date of this Registration Statement and prior to the filing of a post-effective amendment
  which indicates that all securities offered hereby have been sold or which deregisters all securities then remaining unsold shall be deemed
  to be incorporated by reference into this Registration Statement and to be a part hereof from the date of filing of such documents; <I>provided,
  however</I>, that documents or information deemed to have been furnished and not filed in accordance with the rules of the Commission
  shall not be deemed incorporated by reference into this Registration Statement. Any statement contained in a document incorporated or
  deemed to be incorporated by reference herein shall be deemed to be modified or superseded for purposes of this Registration Statement
  to the extent that a statement contained herein or in any subsequently filed document which also is deemed to be incorporated by reference
  herein modifies or supersedes such statement. Any such statement so modified or superseded shall not be deemed, except as so modified
  or superseded, to constitute a part of this Registration Statement.</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"></P>
  
  <!-- Field: Page; Sequence: 3 -->
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  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B>Item&nbsp;4. Description of Securities </B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Not applicable.</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B>Item&nbsp;5. Interests of Named Experts and Counsel </B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Not applicable.</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B>Item&nbsp;6. Indemnification of Directors and Officers </B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Section&nbsp;145 of the Delaware General Corporation Law authorizes
  a corporation to indemnify its directors and officers against liabilities arising out of actions, suits and proceedings to which they
  are made or threatened to be made a party by reason of the fact of their prior or current service to the corporation as a director or
  officer, in accordance with the provisions of Section&nbsp;145, which are sufficiently broad to permit indemnification under certain circumstances
  for liabilities arising under the Securities Act. The indemnity may cover expenses (including attorneys&rsquo; fees) judgments, fines
  and amounts paid in settlement actually and reasonably incurred by the director or officer in connection with any such action, suit or
  proceeding. Section&nbsp;145 permits corporations to pay expenses (including attorneys&rsquo; fees) incurred by directors and officers
  in advance of the final disposition of such action, suit or proceeding. In addition, Section&nbsp;145 provides that a corporation has
  the power to purchase and maintain insurance on behalf of its directors and officers against any liability asserted against them and incurred
  by them in their capacity as a director or officer, or arising out of their status as such, whether or not the corporation would have
  the power to indemnify the director or officer against such liability under Section&nbsp;145.</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">The Registrant&rsquo;s amended and restated certificate of incorporation
  (the &ldquo;Certificate of Incorporation&rdquo;), provides that, to the fullest extent permitted by the Delaware General Corporation Law,
  (1)&nbsp;a director shall not be personally liable to the Registrant or its stockholders for monetary damages for breach of fiduciary
  duty as a director, and (2)&nbsp;the Registrant shall indemnify any director or officer made a party to an action or proceeding, whether
  criminal, civil, administrative or investigative, by reason of the fact of such person&rsquo;s current or prior service as a director
  or officer of the Registrant, any predecessor of the Registrant or any other enterprise per the Registrant&rsquo;s or any predecessor
  to the Registrant&rsquo;s request.</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">The Registrant&rsquo;s amended and restated bylaws, as amended (the
  &ldquo;Bylaws&rdquo;), provide that (a)&nbsp;the Registrant shall indemnify its directors and officers to the maximum extent and in the
  manner permitted by the Delaware General Corporation Law against expenses (including attorneys&rsquo; fees), judgments, fines, ERISA excise
  taxes, settlements and other amounts actually and reasonably incurred in connection with any proceeding, whether civil, criminal, administrative
  or investigative, arising by reason of the fact that such person is or was an agent of the corporation, subject to certain limited exceptions,
  (b)&nbsp;the Registrant shall advance expenses incurred by any director or officer prior to the final disposition of any proceeding to
  which the director or officer was or is or is threatened to be made a party promptly following a request therefore, subject to certain
  limited exceptions, and (c)&nbsp;the rights conferred in the Bylaws are not exclusive.</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">The Registrant has entered into indemnification agreements with each
  of its directors and executive officers to give such directors and officers additional contractual assurances regarding the scope of the
  indemnification set forth in the Certificate of Incorporation and the Bylaws and to provide additional procedural protections. These agreements,
  among other things, provide that the Registrant will indemnify its directors and executive officers for expenses (including attorneys&rsquo;
  fees), judgments, fines, penalties and amounts paid in settlement (including all interest, assessments and other charges paid or payable
  in connection therewith) actually and reasonably incurred by a director or executive officer in connection with any action or proceeding
  to which such person was, is or is threatened to be made a party, a witness or other participant by reason of such person&rsquo;s services
  as a director or executive officer of the Registrant, any of the Registrant&rsquo;s subsidiaries or any other company or enterprise to
  which the person provides services at the Registrant&rsquo;s request, and any federal, state, local or foreign taxes imposed on the director
  or executive officer as a result of the actual or deemed receipt of any payments under the indemnification agreements.</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"></P>
  
  <!-- Field: Page; Sequence: 4 -->
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  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">In addition, the indemnification agreements provide that, upon the
  request of a director or executive officer, the Registrant shall advance expenses (including attorneys&rsquo; fees) to the director or
  officer. The Registrant intends to enter into indemnification agreements with any new directors and executive officers in the future.</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">The Registrant has also obtained insurance policies covering its directors
  and officers with respect to certain liabilities, including liabilities arising under the Securities Act.</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B>Item&nbsp;7. Exemption from Registration Claimed </B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Not applicable.</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B>Item&nbsp;8. Exhibits </B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
  
  <TABLE CELLSPACING="0" CELLPADDING="0" STYLE="width: 100%; border-collapse: collapse; font-size: 10pt">
    <TR STYLE="vertical-align: bottom">
      <TD STYLE="white-space: nowrap"><FONT STYLE="font-size: 10pt"><B>Exhibit<BR>
  Number</B></FONT></TD>
      <TD STYLE="width: 2%">&nbsp;</TD>
      <TD STYLE="border-bottom: black 1pt solid; text-align: center; width: 92%"><FONT STYLE="font-size: 10pt"><B>Documents</B></FONT></TD></TR>
    <TR>
      <TD STYLE="vertical-align: bottom"><FONT STYLE="font-size: 10pt">&nbsp;&nbsp;4.1</FONT></TD>
      <TD STYLE="vertical-align: bottom">&nbsp;</TD>
      <TD STYLE="vertical-align: top; padding-left: 10pt; text-indent: -10pt"><FONT STYLE="font-size: 10pt"><A HREF="e621018_ex4-1.htm" STYLE="-sec-extract: exhibit">Arcturus Therapeutics Holdings Inc. 2021 Inducement Equity Incentive Plan</A> </FONT></TD></TR>
    <TR>
      <TD STYLE="vertical-align: bottom"><FONT STYLE="font-size: 10pt">&nbsp;&nbsp;5.1</FONT></TD>
      <TD STYLE="vertical-align: bottom">&nbsp;</TD>
      <TD STYLE="vertical-align: top; padding-left: 10pt; text-indent: -10pt"><FONT STYLE="font-size: 10pt"><A HREF="e621018_ex5-1.htm" STYLE="-sec-extract: exhibit">Opinion of Dentons US LLP</A> </FONT></TD></TR>
    <TR>
      <TD STYLE="vertical-align: bottom"><FONT STYLE="font-size: 10pt">23.1</FONT></TD>
      <TD STYLE="vertical-align: bottom">&nbsp;</TD>
      <TD STYLE="vertical-align: top; padding-left: 10pt; text-indent: -10pt"><FONT STYLE="font-size: 10pt"><U STYLE="text-decoration: none"><A HREF="e621018_ex23-1.htm" STYLE="-sec-extract: exhibit">Consent of Independent Registered Public Accounting Firm</A></U></FONT></TD></TR>
    <TR>
      <TD STYLE="vertical-align: bottom"><FONT STYLE="font-size: 10pt">23.2</FONT></TD>
      <TD STYLE="vertical-align: bottom">&nbsp;</TD>
      <TD STYLE="vertical-align: top; padding-left: 10pt; text-indent: -10pt"><FONT STYLE="font-size: 10pt"><U STYLE="text-decoration: none"><A HREF="e621018_ex5-1.htm" STYLE="-sec-extract: exhibit">Consent of Dentons US LLP is contained in Exhibit&nbsp;5.1 to this Registration Statement.</A> </U></FONT></TD></TR>
    <TR>
      <TD STYLE="vertical-align: bottom"><FONT STYLE="font-size: 10pt">24.1</FONT></TD>
      <TD STYLE="vertical-align: bottom">&nbsp;</TD>
      <TD STYLE="vertical-align: top; padding-left: 10pt; text-indent: -10pt"><FONT STYLE="font-size: 10pt"><U STYLE="text-decoration: none"><A HREF="#poa">Power of Attorney is contained on the signature page.</A> </U></FONT></TD></TR>
    </TABLE>
  
  <P STYLE="margin-top: 0; margin-bottom: 0">&nbsp;</P>
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B>Item&nbsp;9. Undertakings </B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">(a) The undersigned Registrant hereby undertakes:</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">(1) To file, during any period in which offers or sales are being made,
  a post-effective amendment to this Registration Statement:</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">(i) To include any prospectus required by Section&nbsp;10(a)(3) of
  the Securities Act;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">(ii) To reflect in the prospectus any facts or events arising after
  the effective date of the Registration Statement (or the most recent post-effective amendment thereof) which, individually or in the aggregate,
  represent a fundamental change in the information set forth in the Registration Statement. Notwithstanding the foregoing, any increase
  or decrease in volume of securities offered (if the total dollar value of securities offered would not exceed that which was registered)
  and any deviation from the low or high end of the estimated maximum offering range may be reflected in the form of prospectus filed with
  the Commission pursuant to Rule&nbsp;424(b) if, in the aggregate, the changes in volume and price represent no more than a 20&nbsp;percent
  change in the maximum aggregate offering price set forth in the &ldquo;Calculation of Registration Fee&rdquo; table in the effective Registration
  Statement.</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">(iii) To include any material information with respect to the plan
  of distribution not previously disclosed in the Registration Statement or any material change to such information in the Registration
  Statement.</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><I>Provided, however</I>, that Paragraphs (a)(1)(i) and (a)(1)(ii)
  do not apply if the information required to be included in a post-effective amendment by those paragraphs is contained in reports filed
  with or furnished to the Commission by the registrant pursuant to Section&nbsp;13 or Section&nbsp;15(d) of the 1934 Act (15 U.S.C. 78m
  or 78o(d)) that are incorporated by reference in this Registration Statement.</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">(2) That, for the purpose of determining any liability under the Securities
  Act, each such post-effective amendment shall be deemed to be a new Registration Statement relating to the securities offered therein,
  and the offering of such securities at that time shall be deemed to be the initial bona fide offering thereof.</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"></P>
  
  <!-- Field: Page; Sequence: 5 -->
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  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">(3) To remove from registration by means of a post-effective amendment
  any of the securities being registered which remain unsold at the termination of the offering.</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">(b) The undersigned Registrant hereby undertakes that, for purposes
  of determining any liability under the Securities Act, each filing of the Registrant&rsquo;s annual report pursuant to Section&nbsp;13(a)
  or Section&nbsp;15(d) of the 1934 Act (and, where applicable, each filing of an employee benefit plan&rsquo;s annual report pursuant to
  Section&nbsp;15(d) of the 1934 Act) that is incorporated by reference in this Registration Statement shall be deemed to be a new registration
  statement relating to the securities offered therein, and the offering of such securities at that time shall be deemed to be the initial
  bona fide offering thereof.</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">(c) Insofar as indemnification for liabilities arising under the Securities
  Act may be permitted to directors, officers and controlling persons of the Registrant pursuant to the foregoing provisions, or otherwise,
  the Registrant has been advised that in the opinion of the Commission such indemnification is against public policy as expressed in the
  Securities Act and is, therefore, unenforceable. In the event that a claim for indemnification against such liabilities (other than the
  payment by the Registrant of expenses incurred or paid by a director, officer or controlling person of the Registrant in the successful
  defense of any action, suit or proceeding) is asserted by such director, officer or controlling person in connection with the securities
  being registered, the Registrant will, unless in the opinion of its counsel the matter has been settled by controlling precedent, submit
  to a court of appropriate jurisdiction the question whether such indemnification by it is against public policy as expressed in the Securities
  Act and will be governed by the final adjudication of such issue.</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"></P>
  
  <!-- Field: Page; Sequence: 6 -->
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      <!-- Field: /Page -->
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>SIGNATURES </B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Pursuant to the requirements of the Securities Act of 1933, as amended,
  the Registrant certifies that it has reasonable grounds to believe that it meets all of the requirements for filing on Form S-8 and has
  duly caused this Registration Statement to be signed on its behalf by the undersigned, thereunto duly authorized, in the City of San Diego,
  State of California, on October&nbsp;20, 2021.</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
  
  <TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font-size: 10pt; width: 100%; border-collapse: collapse">
    <TR STYLE="vertical-align: top">
      <TD>&nbsp;</TD>
      <TD COLSPAN="3" STYLE="font-size: 10pt"><FONT STYLE="font-size: 10pt"><B>ARCTURUS THERAPEUTICS HOLDINGS INC.</B></FONT></TD></TR>
    <TR>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD COLSPAN="2">&nbsp;</TD></TR>
    <TR>
      <TD STYLE="width: 60%">&nbsp;</TD>
      <TD STYLE="vertical-align: top; font-size: 10pt; width: 5%"><FONT STYLE="font-size: 10pt">By:</FONT></TD>
      <TD STYLE="vertical-align: bottom; font-size: 10pt; width: 1%">&nbsp;</TD>
      <TD STYLE="vertical-align: top; width: 34%">
      <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; border-bottom: black 0.75pt solid">/s/ Joseph E. Payne</P></TD></TR>
    <TR>
      <TD>&nbsp;</TD>
      <TD STYLE="vertical-align: top">&nbsp;</TD>
      <TD STYLE="vertical-align: bottom; font-size: 10pt">&nbsp;</TD>
      <TD STYLE="vertical-align: top; font-size: 10pt"><FONT STYLE="font-size: 10pt">Joseph E. Payne</FONT></TD></TR>
    <TR>
      <TD>&nbsp;</TD>
      <TD STYLE="vertical-align: top; font-size: 10pt"><FONT STYLE="font-size: 10pt">Title:</FONT></TD>
      <TD STYLE="vertical-align: bottom; font-size: 10pt">&nbsp;</TD>
      <TD STYLE="vertical-align: top; font-size: 10pt"><FONT STYLE="font-size: 10pt">Chief Executive Officer</FONT></TD></TR>
    </TABLE>
  
  <P STYLE="margin-top: 0; margin-bottom: 0">&nbsp;</P>
  
  <P STYLE="margin-top: 0; margin-bottom: 0"></P>
  
  <!-- Field: Page; Sequence: 7 -->
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      <!-- Field: /Page -->
  
  <P STYLE="margin-top: 0; margin-bottom: 0">&nbsp;</P>
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B><A NAME="poa"></A>POWER OF ATTORNEY </B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">We, the undersigned officers and directors of Arcturus Therapeutics
  Holdings Inc., hereby severally constitute and appoint Joseph E. Payne and Dr. Padmanabh Chivukula, and each of them individually, our
  true and lawful attorney to sign for us and in our names in the capacities indicated below any and all amendments or supplements, including
  any post-effective amendments, to this Registration Statement on Form S-8 and to file the same, with exhibits thereto and other documents
  in connection therewith, with the SEC, granting unto said attorney full power and authority to do and perform each and every act and thing
  requisite or necessary to be done in and about the premises, as fully to all intents and purposes as he might or could do in person, hereby
  ratifying and confirming our signatures to said amendments to this Registration Statement signed by our said attorney and all else that
  said attorney may lawfully do and cause to be done by virtue hereof.</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Pursuant to the requirements of the Securities Act of 1933, this Registration
  Statement has been signed below by the following persons on behalf of the Company and in the capacities and on the dates indicated:</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
  
  <TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font-size: 10pt; width: 100%; border-collapse: collapse">
    <TR STYLE="vertical-align: bottom">
      <TD STYLE="white-space: nowrap; border-bottom: black 1pt solid; font-size: 10pt; text-align: center; width: 35%"><FONT STYLE="font-size: 10pt"><B>Signature</B></FONT></TD>
      <TD STYLE="font-size: 10pt; width: 2%">&nbsp;</TD>
      <TD STYLE="white-space: nowrap; border-bottom: black 1pt solid; font-size: 10pt; text-align: center; width: 45%"><FONT STYLE="font-size: 10pt"><B>Title</B></FONT></TD>
      <TD STYLE="font-size: 10pt; width: 2%">&nbsp;</TD>
      <TD STYLE="white-space: nowrap; border-bottom: black 1pt solid; font-size: 10pt; text-align: center; width: 16%"><FONT STYLE="font-size: 10pt"><B>Date</B></FONT></TD></TR>
    <TR>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD></TR>
    <TR>
      <TD STYLE="vertical-align: bottom">
      <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: black 0.75pt solid">/s/ Joseph
  E. Payne</P>
      <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">Joseph E. Payne</P></TD>
      <TD STYLE="vertical-align: bottom; font-size: 10pt">&nbsp;</TD>
      <TD>
      <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">President, Chief Executive Officer and Director</P>
      <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><I>(Principal Executive Officer)</I></P></TD>
      <TD STYLE="vertical-align: bottom; font-size: 10pt">&nbsp;</TD>
      <TD STYLE="vertical-align: top; font-size: 10pt; text-align: center"><FONT STYLE="font-size: 10pt">October&nbsp;20, 2021</FONT></TD></TR>
    <TR>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD></TR>
    <TR>
      <TD STYLE="vertical-align: bottom">
      <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: black 0.75pt solid">/s/ Dr.
  Padmanabh Chivukula</P>
      <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">Dr. Padmanabh Chivukula</P></TD>
      <TD STYLE="vertical-align: bottom; font-size: 10pt">&nbsp;</TD>
      <TD>
      <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">Chief Scientific Officer</P>
      <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">Chief Operating Officer and Secretary</P></TD>
      <TD STYLE="vertical-align: bottom; font-size: 10pt">&nbsp;</TD>
      <TD STYLE="vertical-align: top; font-size: 10pt; text-align: center"><FONT STYLE="font-size: 10pt">October&nbsp;20, 2021</FONT></TD></TR>
    <TR>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD></TR>
    <TR>
      <TD STYLE="vertical-align: bottom">
      <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: black 0.75pt solid">/s/ Dr.
  Peter Farrell</P>
      <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">Dr. Peter Farrell</P></TD>
      <TD STYLE="vertical-align: bottom; font-size: 10pt">&nbsp;</TD>
      <TD STYLE="font-size: 10pt; text-align: center"><FONT STYLE="font-size: 10pt">Chairman of the Board</FONT></TD>
      <TD STYLE="vertical-align: bottom; font-size: 10pt">&nbsp;</TD>
      <TD STYLE="font-size: 10pt; text-align: center"><FONT STYLE="font-size: 10pt">October&nbsp;20, 2021</FONT></TD></TR>
    <TR>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD></TR>
    <TR>
      <TD STYLE="vertical-align: bottom">
      <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: black 0.75pt solid">/s/ Andy
  Sassine</P>
      <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">Andy Sassine</P></TD>
      <TD STYLE="vertical-align: bottom; font-size: 10pt">&nbsp;</TD>
      <TD>
      <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">Director, Chief Financial Officer</P>
      <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">(<I>principal financial officer</I>)</P></TD>
      <TD STYLE="vertical-align: bottom; font-size: 10pt">&nbsp;</TD>
      <TD STYLE="font-size: 10pt; text-align: center"><FONT STYLE="font-size: 10pt">October&nbsp;20, 2021</FONT></TD></TR>
    <TR>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD></TR>
    <TR>
      <TD STYLE="vertical-align: bottom">
      <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: black 0.75pt solid">/s/ Dr.
  Magda Marquet</P>
      <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">Dr. Magda Marquet</P></TD>
      <TD STYLE="vertical-align: bottom; font-size: 10pt">&nbsp;</TD>
      <TD STYLE="font-size: 10pt; text-align: center"><FONT STYLE="font-size: 10pt">Director</FONT></TD>
      <TD STYLE="vertical-align: bottom; font-size: 10pt">&nbsp;</TD>
      <TD STYLE="font-size: 10pt; text-align: center"><FONT STYLE="font-size: 10pt">October&nbsp;20, 2021</FONT></TD></TR>
    <TR>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD></TR>
    <TR>
      <TD STYLE="vertical-align: bottom">
      <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: black 0.75pt solid">/s/ James
  Barlow</P>
      <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">James Barlow</P></TD>
      <TD STYLE="vertical-align: bottom; font-size: 10pt">&nbsp;</TD>
      <TD STYLE="font-size: 10pt; text-align: center"><FONT STYLE="font-size: 10pt">Director</FONT></TD>
      <TD STYLE="vertical-align: bottom; font-size: 10pt">&nbsp;</TD>
      <TD STYLE="font-size: 10pt; text-align: center"><FONT STYLE="font-size: 10pt">October&nbsp;20, 2021</FONT></TD></TR>
    <TR>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD></TR>
    <TR>
      <TD STYLE="vertical-align: bottom">
      <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: black 0.75pt solid">/s/ Dr.
  Edward Holmes</P>
      <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">Dr. Edward Holmes</P></TD>
      <TD STYLE="vertical-align: bottom; font-size: 10pt">&nbsp;</TD>
      <TD STYLE="font-size: 10pt; text-align: center"><FONT STYLE="font-size: 10pt">Director</FONT></TD>
      <TD STYLE="vertical-align: bottom; font-size: 10pt">&nbsp;</TD>
      <TD STYLE="font-size: 10pt; text-align: center"><FONT STYLE="font-size: 10pt">October&nbsp;20, 2021</FONT></TD></TR>
    <TR>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD></TR>
    <TR>
      <TD STYLE="vertical-align: bottom">
      <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: black 0.75pt solid">/s/ Keith
  C. Kummerfeld</P>
      <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">Keith C. Kummerfeld</P></TD>
      <TD STYLE="vertical-align: bottom; font-size: 10pt">&nbsp;</TD>
      <TD>
      <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 22.5pt 0pt 0; text-align: center; text-indent: 18.75pt">Vice President
  of Finance and Corporate Controller</P>
      <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">(<I>principal accounting officer</I>)</P></TD>
      <TD STYLE="vertical-align: bottom; font-size: 10pt">&nbsp;</TD>
      <TD STYLE="font-size: 10pt; text-align: center"><FONT STYLE="font-size: 10pt">October&nbsp;20, 2021</FONT></TD></TR>
    </TABLE>
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>
  
  </BODY>
  </HTML>
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metadata_filer: {"company-data": {"conformed-name": "Arcturus Therapeutics Holdings Inc.", "cik": "0001768224", "assigned-sic": "2834", "irs-number": "000000000", "state-of-incorporation": "DE", "fiscal-year-end": "1231"}, "filing-values": {"form-type": "S-8", "act": "33", "file-number": "333-260391", "film-number": "211334957"}, "business-address": {"street1": "10628 SCIENCE CENTER DRIVE", "street2": "SUITE 250", "city": "SAN DIEGO", "state": "CA", "zip": "92121", "phone": "8589002660"}, "mail-address": {"street1": "10628 SCIENCE CENTER DRIVE", "street2": "SUITE 250", "city": "SAN DIEGO", "state": "CA", "zip": "92121"}}
text: As filed with the Securities and Exchange Commission
  on October 20, 2021
  Registration No. 333-
  UNITED STATES
  SECURITIES AND
  EXCHANGE COMMISSION
  Washington, D.C.
  20549
  FORM S-8
  REGISTRATION
  STATEMENT
  UNDER
  THE SECURITIES
  ACT OF 1933
  ARCTURUS THERAPEUTICS HOLDINGS INC.
  (Exact name of Registrant as specified in its
  charter)
  Delaware
  32-0595345
  (State or other jurisdiction of
  incorporation or organization)
  (I.R.S. Employer
  Identification Number)
  10628 Science Center Drive, Suite 250
  San Diego, California
  92121
  (Address of principal executive offices)
  (Zip code)
  ARCTURUS THERAPEUTICS HOLDINGS INC. 2021 INDUCEMENT
  EQUITY INCENTIVE PLAN
  (Full title of the plan)
  Joseph E. Payne
  Chief Executive Officer
  Arcturus Therapeutics Holdings Inc.
  10628 Science Center Drive, Suite 250
  San Diego, California 92121
  (Name and address of agent for service)
  (858) 900-2660
  (Telephone number, including area code, of agent
  for service)
  Copies to:
  Dentons US LLP
  1221 Avenue of the Americas
  New York, New York 10020
  Jeffrey A. Baumel, Esq.
  Ilan Katz, Esq.
  Indicate by check mark whether the registrant is a large accelerated
  filer, an accelerated filer, a non-accelerated filer, a smaller reporting company, or an emerging growth company. See the definitions
  of "large accelerated filer," "accelerated filer," "smaller reporting company," and "emerging
  growth company" in Rule 12b-2 of the Exchange Act. (Check one):
  Large accelerated filer
  ☒
  Accelerated filer
  ☐
  Non-accelerated filer
  ☐
  Smaller reporting company
  ☐
  Emerging growth company
  ☐
  If an emerging growth company, indicate by check mark if the registrant
  has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant
  to Section 7(a)(2)(B) of the Securities Act
  ☐
  CALCULATION OF REGISTRATION FEE
  Title of Securities
  to be Registered
  Amount
  to be
  Registered(1)
  Proposed
  Maximum
  Offering Price
  Per Share
  Proposed
  Maximum
  Aggregate
  Offering Price
  Amount of
  Registration Fee
  Common Stock (par value $0.001) reserved for issuance under the Arcturus Therapeutics Holdings Inc. 2021 Inducement Equity Incentive Plan
  1,000,000
  $45.17 (2)
  $45,170,000
  $4,187.26 (3)
  (1)
  Pursuant to Rule 416(a) of the Securities Act of 1933, as amended (the "Securities Act"), this registration statement (the "Registration Statement") shall also cover any additional shares of Common Stock of Arcturus Therapeutics Holdings Inc.  (the "Registrant") that become issuable in respect of the securities identified in the above table by reason of any stock dividend, stock split, recapitalization or other similar transaction effected without the receipt of consideration that increases the number of outstanding shares of the Registrant's Common Stock.
  (2)
  Estimated solely for the purpose of calculating the registration fee in accordance with Rules 457(c) and 457(h) under the Securities Act on the basis of the average of the reported high and low sales prices for the Registrant's common stock as reported by the Nasdaq Global Market on October 19, 2021.
  (3)
  The amount of the registration fee is calculated pursuant to Section 6(b) of the Securities Act, which currently provides that the filing fee rate shall be "$92.70 per $1 million" of the maximum aggregate price at which such securities are proposed to be offered. The Registration Fee is therefore calculated by multiplying the Proposed Maximum Aggregate Offering Price by 0.0000927.
  PART I
  INFORMATION REQUIRED IN THE SECTION 10(a) PROSPECTUS
  Item 1. Plan Information
  The documents containing the information specified in this Item 1 will
  be sent or given to participants as specified by Rule 428(b)(1) under the Securities Act. In accordance with the rules and regulations
  of the Securities and Exchange Commission (the "Commission") and the instructions to Form S-8, such documents are not being
  filed with the Commission either as part of this Registration Statement or as prospectuses or prospectus supplements pursuant to Rule 424
  under the Securities Act.
  Item 2. Registration Information and Employee Plan Annual Information
  The documents containing the information specified in this Item 2
  will be sent or given to participants as specified by Rule 428(b)(1) under the Securities Act. In accordance with the rules and
  regulations of the Commission and the instructions to Form S-8, such documents are not being filed with the Commission either as part
  of this Registration Statement or as prospectuses or prospectus supplements pursuant to Rule 424 under the Securities Act. Such
  documents, together with the documents incorporated by reference herein pursuant to Item 3 of Part II of this Registration Statement
  on Form S-8, constitute a prospectus that meets the requirements of Section 10(a) of the Securities Act, and are available upon
  written or oral request to: Arcturus Therapeutics Holdings Inc., Attn: Chief Financial Officer, Arcturus Therapeutics Holdings Inc.,
  10628 Science Center Drive, Suite 250, San Diego, California 92121, Tel: (858) 900-2660.
  PART II
  INFORMATION REQUIRED IN THE REGISTRATION STATEMENT
  Item 3. Incorporation of Documents by Reference
  The Registrant hereby incorporates by reference into this Registration
  Statement the following documents previously filed with the Commission (other than information in a report on Form 8-K that is furnished
  and not filed pursuant to Form 8-K and, except as may be noted in any such Form 8-K, exhibits filed on such form that are related to such
  information):
  (i) The Registrant's Annual Report on
  Form
  10-K
  for the fiscal year ended December 31, 2020, filed with the Commission on March  1, 2021, including the information
  specifically incorporated by reference therein from our Definitive Proxy Statement on
  Schedule 14A
  filed with the Commission on April 30, 2021, pursuant to Section 13 of the Securities Exchange Act of 1934, as amended (the
  "1934 Act");
  (ii) The Registrant's Quarterly Report on
  Form
  10-Q
  for the periods ended March 31, 2021 and June 30, 2021, filed with the Commission on May 10, 2021 and August
  10, 2021;
  (iii) The Registrant's Current Reports on Form 8-K filed with
  the Commission pursuant to Section 13 of the 1934 Act on February 3, 2021, February 22, 2021,
  March 1,
  2021
  ,
  April 26, 2021
  ,
  May 10, 2021
  ,
  June 22,
  2021
  ,
  August 4, 2021
  ,
  August 9, 2021
  ,
  August
  26
  ,
  2021
  and
  October 5, 2021
  ; and
  (iii) The description of the Registrant's common stock set forth
  in the registration statement on Form 8-A registering the Registrant's common stock under Section 12 of the Exchange Act, as filed
  with the SEC on May 17, 2013, including any amendments or reports filed for purposes of updating such description, including the Form
  8-K12B filed on June 14, 2019.
  All documents filed by the Registrant pursuant to Section 13(a),
  13(c), 14 or 15(d) of the 1934 Act after the date of this Registration Statement and prior to the filing of a post-effective amendment
  which indicates that all securities offered hereby have been sold or which deregisters all securities then remaining unsold shall be deemed
  to be incorporated by reference into this Registration Statement and to be a part hereof from the date of filing of such documents;
  provided,
  however
  , that documents or information deemed to have been furnished and not filed in accordance with the rules of the Commission
  shall not be deemed incorporated by reference into this Registration Statement. Any statement contained in a document incorporated or
  deemed to be incorporated by reference herein shall be deemed to be modified or superseded for purposes of this Registration Statement
  to the extent that a statement contained herein or in any subsequently filed document which also is deemed to be incorporated by reference
  herein modifies or supersedes such statement. Any such statement so modified or superseded shall not be deemed, except as so modified
  or superseded, to constitute a part of this Registration Statement.
  Item 4. Description of Securities
  Not applicable.
  Item 5. Interests of Named Experts and Counsel
  Not applicable.
  Item 6. Indemnification of Directors and Officers
  Section 145 of the Delaware General Corporation Law authorizes
  a corporation to indemnify its directors and officers against liabilities arising out of actions, suits and proceedings to which they
  are made or threatened to be made a party by reason of the fact of their prior or current service to the corporation as a director or
  officer, in accordance with the provisions of Section 145, which are sufficiently broad to permit indemnification under certain circumstances
  for liabilities arising under the Securities Act. The indemnity may cover expenses (including attorneys' fees) judgments, fines
  and amounts paid in settlement actually and reasonably incurred by the director or officer in connection with any such action, suit or
  proceeding. Section 145 permits corporations to pay expenses (including attorneys' fees) incurred by directors and officers
  in advance of the final disposition of such action, suit or proceeding. In addition, Section 145 provides that a corporation has
  the power to purchase and maintain insurance on behalf of its directors and officers against any liability asserted against them and incurred
  by them in their capacity as a director or officer, or arising out of their status as such, whether or not the corporation would have
  the power to indemnify the director or officer against such liability under Section 145.
  The Registrant's amended and restated certificate of incorporation
  (the "Certificate of Incorporation"), provides that, to the fullest extent permitted by the Delaware General Corporation Law,
  (1) a director shall not be personally liable to the Registrant or its stockholders for monetary damages for breach of fiduciary
  duty as a director, and (2) the Registrant shall indemnify any director or officer made a party to an action or proceeding, whether
  criminal, civil, administrative or investigative, by reason of the fact of such person's current or prior service as a director
  or officer of the Registrant, any predecessor of the Registrant or any other enterprise per the Registrant's or any predecessor
  to the Registrant's request.
  The Registrant's amended and restated bylaws, as amended (the
  "Bylaws"), provide that (a) the Registrant shall indemnify its directors and officers to the maximum extent and in the
  manner permitted by the Delaware General Corporation Law against expenses (including attorneys' fees), judgments, fines, ERISA excise
  taxes, settlements and other amounts actually and reasonably incurred in connection with any proceeding, whether civil, criminal, administrative
  or investigative, arising by reason of the fact that such person is or was an agent of the corporation, subject to certain limited exceptions,
  (b) the Registrant shall advance expenses incurred by any director or officer prior to the final disposition of any proceeding to
  which the director or officer was or is or is threatened to be made a party promptly following a request therefore, subject to certain
  limited exceptions, and (c) the rights conferred in the Bylaws are not exclusive.
  The Registrant has entered into indemnification agreements with each
  of its directors and executive officers to give such directors and officers additional contractual assurances regarding the scope of the
  indemnification set forth in the Certificate of Incorporation and the Bylaws and to provide additional procedural protections. These agreements,
  among other things, provide that the Registrant will indemnify its directors and executive officers for expenses (including attorneys'
  fees), judgments, fines, penalties and amounts paid in settlement (including all interest, assessments and other charges paid or payable
  in connection therewith) actually and reasonably incurred by a director or executive officer in connection with any action or proceeding
  to which such person was, is or is threatened to be made a party, a witness or other participant by reason of such person's services
  as a director or executive officer of the Registrant, any of the Registrant's subsidiaries or any other company or enterprise to
  which the person provides services at the Registrant's request, and any federal, state, local or foreign taxes imposed on the director
  or executive officer as a result of the actual or deemed receipt of any payments under the indemnification agreements.
  In addition, the indemnification agreements provide that, upon the
  request of a director or executive officer, the Registrant shall advance expenses (including attorneys' fees) to the director or
  officer. The Registrant intends to enter into indemnification agreements with any new directors and executive officers in the future.
  The Registrant has also obtained insurance policies covering its directors
  and officers with respect to certain liabilities, including liabilities arising under the Securities Act.
  Item 7. Exemption from Registration Claimed
  Not applicable.
  Item 8. Exhibits
  Exhibit
  Number
  Documents
  4.1
  Arcturus Therapeutics Holdings Inc. 2021 Inducement Equity Incentive Plan
  5.1
  Opinion of Dentons US LLP
  23.1
  Consent of Independent Registered Public Accounting Firm
  23.2
  Consent of Dentons US LLP is contained in Exhibit 5.1 to this Registration Statement.
  24.1
  Power of Attorney is contained on the signature page.
  Item 9. Undertakings
  (a) The undersigned Registrant hereby undertakes:
  (1) To file, during any period in which offers or sales are being made,
  a post-effective amendment to this Registration Statement:
  (i) To include any prospectus required by Section 10(a)(3) of
  the Securities Act;
  (ii) To reflect in the prospectus any facts or events arising after
  the effective date of the Registration Statement (or the most recent post-effective amendment thereof) which, individually or in the aggregate,
  represent a fundamental change in the information set forth in the Registration Statement. Notwithstanding the foregoing, any increase
  or decrease in volume of securities offered (if the total dollar value of securities offered would not exceed that which was registered)
  and any deviation from the low or high end of the estimated maximum offering range may be reflected in the form of prospectus filed with
  the Commission pursuant to Rule 424(b) if, in the aggregate, the changes in volume and price represent no more than a 20 percent
  change in the maximum aggregate offering price set forth in the "Calculation of Registration Fee" table in the effective Registration
  Statement.
  (iii) To include any material information with respect to the plan
  of distribution not previously disclosed in the Registration Statement or any material change to such information in the Registration
  Statement.
  Provided, however
  , that Paragraphs (a)(1)(i) and (a)(1)(ii)
  do not apply if the information required to be included in a post-effective amendment by those paragraphs is contained in reports filed
  with or furnished to the Commission by the registrant pursuant to Section 13 or Section 15(d) of the 1934 Act (15 U.S.C. 78m
  or 78o(d)) that are incorporated by reference in this Registration Statement.
  (2) That, for the purpose of determining any liability under the Securities
  Act, each such post-effective amendment shall be deemed to be a new Registration Statement relating to the securities offered therein,
  and the offering of such securities at that time shall be deemed to be the initial bona fide offering thereof.
  (3) To remove from registration by means of a post-effective amendment
  any of the securities being registered which remain unsold at the termination of the offering.
  (b) The undersigned Registrant hereby undertakes that, for purposes
  of determining any liability under the Securities Act, each filing of the Registrant's annual report pursuant to Section 13(a)
  or Section 15(d) of the 1934 Act (and, where applicable, each filing of an employee benefit plan's annual report pursuant to
  Section 15(d) of the 1934 Act) that is incorporated by reference in this Registration Statement shall be deemed to be a new registration
  statement relating to the securities offered therein, and the offering of such securities at that time shall be deemed to be the initial
  bona fide offering thereof.
  (c) Insofar as indemnification for liabilities arising under the Securities
  Act may be permitted to directors, officers and controlling persons of the Registrant pursuant to the foregoing provisions, or otherwise,
  the Registrant has been advised that in the opinion of the Commission such indemnification is against public policy as expressed in the
  Securities Act and is, therefore, unenforceable. In the event that a claim for indemnification against such liabilities (other than the
  payment by the Registrant of expenses incurred or paid by a director, officer or controlling person of the Registrant in the successful
  defense of any action, suit or proceeding) is asserted by such director, officer or controlling person in connection with the securities
  being registered, the Registrant will, unless in the opinion of its counsel the matter has been settled by controlling precedent, submit
  to a court of appropriate jurisdiction the question whether such indemnification by it is against public policy as expressed in the Securities
  Act and will be governed by the final adjudication of such issue.
  SIGNATURES
  Pursuant to the requirements of the Securities Act of 1933, as amended,
  the Registrant certifies that it has reasonable grounds to believe that it meets all of the requirements for filing on Form S-8 and has
  duly caused this Registration Statement to be signed on its behalf by the undersigned, thereunto duly authorized, in the City of San Diego,
  State of California, on October 20, 2021.
  ARCTURUS THERAPEUTICS HOLDINGS INC.
  By:
  /s/ Joseph E. Payne
  Joseph E. Payne
  Title:
  Chief Executive Officer
  POWER OF ATTORNEY
  We, the undersigned officers and directors of Arcturus Therapeutics
  Holdings Inc., hereby severally constitute and appoint Joseph E. Payne and Dr. Padmanabh Chivukula, and each of them individually, our
  true and lawful attorney to sign for us and in our names in the capacities indicated below any and all amendments or supplements, including
  any post-effective amendments, to this Registration Statement on Form S-8 and to file the same, with exhibits thereto and other documents
  in connection therewith, with the SEC, granting unto said attorney full power and authority to do and perform each and every act and thing
  requisite or necessary to be done in and about the premises, as fully to all intents and purposes as he might or could do in person, hereby
  ratifying and confirming our signatures to said amendments to this Registration Statement signed by our said attorney and all else that
  said attorney may lawfully do and cause to be done by virtue hereof.
  Pursuant to the requirements of the Securities Act of 1933, this Registration
  Statement has been signed below by the following persons on behalf of the Company and in the capacities and on the dates indicated:
  Signature
  Title
  Date
  /s/ Joseph
  E. Payne
  Joseph E. Payne
  President, Chief Executive Officer and Director
  (Principal Executive Officer)
  October 20, 2021
  /s/ Dr.
  Padmanabh Chivukula
  Dr. Padmanabh Chivukula
  Chief Scientific Officer
  Chief Operating Officer and Secretary
  October 20, 2021
  /s/ Dr.
  Peter Farrell
  Dr. Peter Farrell
  Chairman of the Board
  October 20, 2021
  /s/ Andy
  Sassine
  Andy Sassine
  Director, Chief Financial Officer
  (
  principal financial officer
  )
  October 20, 2021
  /s/ Dr.
  Magda Marquet
  Dr. Magda Marquet
  Director
  October 20, 2021
  /s/ James
  Barlow
  James Barlow
  Director
  October 20, 2021
  /s/ Dr.
  Edward Holmes
  Dr. Edward Holmes
  Director
  October 20, 2021
  /s/ Keith
  C. Kummerfeld
  Keith C. Kummerfeld
  Vice President
  of Finance and Corporate Controller
  (
  principal accounting officer
  )
  October 20, 2021