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  <!-- Field: Rule-Page --><DIV STYLE="margin: 3pt auto; width: 100%"><DIV STYLE="font-size: 1pt; border-top: Black 2pt solid; border-bottom: Black 1pt solid">&nbsp;</DIV></DIV><!-- Field: /Rule-Page -->
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center"><B>As filed with the Securities and Exchange
  Commission on June 23, 2020</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0 0 0 0.5in; text-align: right; text-indent: 0.5in"><B>Registration
  No.&nbsp; 333-&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0 0 0 0.5in; text-align: right; text-indent: 0.5in">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center">&nbsp;</P>
  
  <P STYLE="font: 18pt Times New Roman, Times, Serif; margin: 0; text-align: center"><B>UNITED STATES</B></P>
  
  <P STYLE="font: 18pt Times New Roman, Times, Serif; margin: 0; text-align: center"><B>SECURITIES AND EXCHANGE COMMISSION</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center"><B>WASHINGTON, D.C. 20549</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center"></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center">&nbsp;</P>
  
  <P STYLE="font: 18pt Times New Roman, Times, Serif; margin: 0; text-align: center"><B>FORM S-8</B></P>
  
  <P STYLE="font: 18pt Times New Roman, Times, Serif; margin: 0; text-align: center"><B>REGISTRATION STATEMENT</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center"><B><I>UNDER</I></B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center"><B><I>THE SECURITIES ACT OF 1933</I></B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center">&nbsp;<B>&nbsp;</B></P>
  
  <P STYLE="font: 24pt Times New Roman, Times, Serif; margin: 0; text-align: center"><B>COHBAR, INC.</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center"><B>(Exact name of Registrant as specified in
  its charter)</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-indent: 0.5in">&nbsp;</P>
  
  <TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
  <TR>
      <TD STYLE="vertical-align: top; width: 46%; border-bottom: black 1.5pt solid; text-align: center"><FONT STYLE="font-size: 10pt"><B>Delaware</B></FONT></TD>
      <TD STYLE="vertical-align: bottom; width: 9%">&nbsp;</TD>
      <TD STYLE="vertical-align: top; width: 45%; border-bottom: black 1.5pt solid; text-align: center"><FONT STYLE="font-size: 10pt"><B>26-1299952</B></FONT></TD></TR>
  <TR>
      <TD STYLE="vertical-align: top; text-align: center"><FONT STYLE="font-size: 10pt"><B>(State or other jurisdiction of</B><BR>
  <B>incorporation or organization)</B></FONT></TD>
      <TD STYLE="vertical-align: bottom">&nbsp;</TD>
      <TD STYLE="vertical-align: top; text-align: center"><FONT STYLE="font-size: 10pt"><B>(I.R.S. Employer</B><BR>
  <B>Identification Number)</B></FONT></TD></TR>
  </TABLE>
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center"><B>&nbsp;</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center"><B>1455 Adams Drive, Suite 2050</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center"><B>Menlo Park, CA 94025</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center"><B>(650) 446-7888&nbsp;</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center"><B>(Address, including zip code, of principal
  executive offices)</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center"><B>&nbsp;</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center"><B>Amended and Restated 2011 Equity Incentive
  Plan</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center"><B>(Full title of the plan)</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center"><B>&nbsp;</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center"><B>Steven Engle</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center"><B>Chief Executive Officer</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center"><B>CohBar, Inc.</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center"><B>1455 Adams Drive, Suite 2050</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center"><B>Menlo Park, CA 94025</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center"><B>(650) 446-7888&nbsp;</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center"><B>(Name and address, and telephone number,
  including area code, of agent for service)</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center"><B>&nbsp;</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center"><B><I>Please send copies of all communications
  to:</I></B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center"><B>&nbsp;</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center"><B>Amanda Rose, Esq.</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center"><B>Chelsea Anderson, Esq.</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center"><B>Fenwick &amp; West LLP</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center"><B>1191 Second Avenue, Floor 10</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center"><B>Seattle, WA 98101</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center"><B>(206) 389-4510&nbsp;</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center"></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 12pt 0 0">Indicate by check mark whether the Registrant is a large
  accelerated filer, an accelerated filer, a non-accelerated filer, a smaller reporting company, or an emerging growth company. See
  the definitions of &ldquo;large accelerated filer,&rdquo; &ldquo;accelerated filer,&rdquo; &ldquo;smaller reporting company,&rdquo;
  and &ldquo;emerging growth company&rdquo; in Rule 12b-2 of the Exchange Act.</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>
  
  <TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
  <TR>
      <TD STYLE="width: 17%">&nbsp;</TD>
      <TD STYLE="vertical-align: bottom; width: 1%">&nbsp;</TD>
      <TD STYLE="width: 58%">&nbsp;</TD>
      <TD STYLE="vertical-align: bottom; width: 1%">&nbsp;</TD>
      <TD STYLE="width: 21%">&nbsp;</TD>
      <TD STYLE="vertical-align: bottom; width: 1%">&nbsp;</TD>
      <TD STYLE="width: 1%">&nbsp;</TD></TR>
  <TR STYLE="vertical-align: bottom">
      <TD><FONT STYLE="font-size: 10pt">Large&nbsp;accelerated&nbsp;filer</FONT></TD>
      <TD>&nbsp;</TD>
      <TD><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#9744;</FONT></TD>
      <TD>&nbsp;</TD>
      <TD><FONT STYLE="font-size: 10pt">Accelerated&nbsp;filer</FONT></TD>
      <TD>&nbsp;</TD>
      <TD><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#9744;</FONT></TD></TR>
  <TR>
      <TD>&nbsp;</TD>
      <TD COLSPAN="2">&nbsp;</TD>
      <TD COLSPAN="2">&nbsp;</TD>
      <TD COLSPAN="2">&nbsp;</TD></TR>
  <TR STYLE="vertical-align: bottom">
      <TD><FONT STYLE="font-size: 10pt">Non-accelerated filer</FONT></TD>
      <TD>&nbsp;</TD>
      <TD><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#9746;</FONT><FONT STYLE="font-size: 10pt">&nbsp;&nbsp;</FONT></TD>
      <TD>&nbsp;</TD>
      <TD><FONT STYLE="font-size: 10pt">Smaller&nbsp;reporting&nbsp;company</FONT></TD>
      <TD>&nbsp;</TD>
      <TD><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#9746;</FONT></TD></TR>
  <TR>
      <TD>&nbsp;</TD>
      <TD COLSPAN="2">&nbsp;</TD>
      <TD COLSPAN="2">&nbsp;</TD>
      <TD COLSPAN="2">&nbsp;</TD></TR>
  <TR STYLE="vertical-align: bottom">
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD><FONT STYLE="font-size: 10pt">Emerging&nbsp;growth&nbsp;company</FONT></TD>
      <TD>&nbsp;</TD>
      <TD><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#9746;</FONT></TD></TR>
  </TABLE>
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 12pt 0 0">If an emerging growth company, indicate by check mark if
  the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting
  standards provided pursuant to Section&nbsp;7(a)(2)(B) of the Securities Act.&nbsp;&nbsp;<FONT STYLE="font-family: Times New Roman, Times, Serif">&#9744;</FONT></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 12pt 0 0"><FONT STYLE="font-family: Times New Roman, Times, Serif"></FONT></P>
  
  <!-- Field: Rule-Page --><DIV STYLE="margin: 3pt auto; width: 100%"><DIV STYLE="font-size: 1pt; border-top: Black 1pt solid; border-bottom: Black 2pt solid">&nbsp;</DIV></DIV><!-- Field: /Rule-Page -->
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 12pt 0 0"><FONT STYLE="font-family: Times New Roman, Times, Serif"></FONT></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0"></P>
  
  <!-- Field: Page; Sequence: 1 -->
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  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center"><B>CALCULATION OF REGISTRATION FEE</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center"><B>&nbsp;</B></P>
  
  <TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
  <TR STYLE="vertical-align: bottom">
      <TD STYLE="border-bottom: Black 1pt solid; padding-bottom: 1.5pt; text-align: center"><FONT STYLE="font-size: 10pt"><B>Title of<BR>
  Securities&nbsp;to be Registered</B></FONT></TD>
      <TD STYLE="border-bottom: Black 1pt solid">&nbsp;</TD>
      <TD COLSPAN="2" STYLE="border-bottom: Black 1pt solid; padding-bottom: 1.5pt">
          <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center"><B>Amount<BR>
          to be</B></P>
          <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center"><B>Registered<SUP>(1)</SUP></B></P></TD>
      <TD STYLE="border-bottom: Black 1pt solid">&nbsp;</TD>
      <TD COLSPAN="2" STYLE="border-bottom: Black 1pt solid; padding-bottom: 1.5pt">
          <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center"><B>Proposed<BR>
          Maximum</B></P>
          <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center"><B>Offering Price</B></P>
          <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center"><B>Per Share</B><SUP>(3)</SUP></P></TD>
      <TD STYLE="border-bottom: Black 1pt solid">&nbsp;</TD>
      <TD STYLE="border-bottom: Black 1pt solid">&nbsp;</TD>
      <TD COLSPAN="2" STYLE="border-bottom: Black 1pt solid; padding-bottom: 1.5pt">
          <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center"><B>Proposed<BR>
          Maximum</B></P>
          <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center"><B>Aggregate<BR>
          Offering&nbsp;Price</B></P></TD>
      <TD STYLE="border-bottom: Black 1pt solid">&nbsp;</TD>
      <TD STYLE="border-bottom: Black 1pt solid">&nbsp;</TD>
      <TD COLSPAN="2" STYLE="border-bottom: Black 1pt solid; padding-bottom: 1.5pt">
          <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center"><B>Amount of</B></P>
          <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center"><B>Registration&nbsp;Fee</B></P></TD>
      <TD STYLE="border-bottom: Black 1pt solid">&nbsp;</TD></TR>
  <TR STYLE="vertical-align: bottom; background-color: White">
      <TD STYLE="border-left: Black 1pt solid"><FONT STYLE="font-size: 10pt">Common Stock, par value $0.001 per share</FONT></TD>
      <TD STYLE="border-right: Black 1pt solid">&nbsp;</TD>
      <TD COLSPAN="2" STYLE="border-right: Black 1pt solid; text-align: right">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD STYLE="border-right: Black 1pt solid">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD STYLE="border-right: Black 1pt solid">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD STYLE="border-right: Black 1pt solid">&nbsp;</TD></TR>
  <TR STYLE="background-color: rgb(204,238,255)">
      <TD COLSPAN="2" STYLE="border-left: Black 1pt solid; border-bottom: Black 1pt solid; padding-bottom: 1.5pt; vertical-align: top; border-top: Black 1pt solid; padding-left: 12pt; text-indent: -12pt"><FONT STYLE="font-size: 10pt">&mdash; To be issued under the Amended and Restated 2011 Equity Incentive Plan</FONT></TD>
      <TD STYLE="border-bottom: Black 1pt solid; padding-bottom: 1.5pt; vertical-align: bottom; border-top: Black 1pt solid; border-left: black 1pt solid">&nbsp;</TD>
      <TD STYLE="border-bottom: Black 1pt solid; padding-bottom: 1.5pt; vertical-align: bottom; border-top: Black 1pt solid; text-align: center"><FONT STYLE="font-size: 10pt">4,000,000(2)</FONT></TD>
      <TD STYLE="border-bottom: Black 1pt solid; padding-bottom: 1.5pt; vertical-align: bottom; border-top: Black 1pt solid; border-left: black 1pt solid">&nbsp;</TD>
      <TD COLSPAN="5" STYLE="border-bottom: Black 1pt solid; padding-bottom: 1.5pt; vertical-align: bottom; border-top: Black 1pt solid; text-align: center"><FONT STYLE="font-size: 10pt">$2.365</FONT></TD>
      <TD STYLE="border-bottom: Black 1pt solid; padding-bottom: 1.5pt; vertical-align: bottom; border-top: Black 1pt solid; border-left: black 1pt solid; text-align: center"><P STYLE="margin: 0pt 0; font: 10pt Times New Roman, Times, Serif">$9,460,000</P></TD>
      <TD COLSPAN="3" STYLE="border-bottom: Black 1pt solid; padding-bottom: 1.5pt; vertical-align: bottom; border-top: Black 1pt solid">&nbsp;</TD>
      <TD STYLE="border-bottom: Black 1pt solid; padding-bottom: 1.5pt; vertical-align: bottom; border-top: Black 1pt solid; border-left: black 1pt solid; text-align: center"><P STYLE="margin: 0pt 0; font: 10pt Times New Roman, Times, Serif">$1,228</P></TD>
      <TD STYLE="border-right: Black 1pt solid; border-bottom: Black 1pt solid; padding-bottom: 1.5pt; vertical-align: bottom; border-top: Black 1pt solid">&nbsp;</TD></TR>
  <TR STYLE="background-color: White">
      <TD STYLE="width: 36%">&nbsp;</TD>
      <TD STYLE="width: 1%">&nbsp;</TD>
      <TD STYLE="width: 1%">&nbsp;</TD>
      <TD STYLE="width: 20%">&nbsp;</TD>
      <TD STYLE="width: 1%">&nbsp;</TD>
      <TD STYLE="width: 1%">&nbsp;</TD>
      <TD STYLE="width: 8%">&nbsp;</TD>
      <TD STYLE="width: 1%">&nbsp;</TD>
      <TD STYLE="width: 1%">&nbsp;</TD>
      <TD STYLE="width: 1%">&nbsp;</TD>
      <TD STYLE="width: 12%">&nbsp;</TD>
      <TD STYLE="width: 1%">&nbsp;</TD>
      <TD STYLE="width: 1%">&nbsp;</TD>
      <TD STYLE="width: 1%">&nbsp;</TD>
      <TD STYLE="width: 13%">&nbsp;</TD>
      <TD STYLE="width: 1%">&nbsp;</TD></TR>
  </TABLE>
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0"></P>
  
  <TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%">
  <TR STYLE="vertical-align: top">
      <TD STYLE="width: 1%; text-align: right"><FONT STYLE="font-size: 10pt">(1)</FONT></TD>
      <TD STYLE="width: 1%">&nbsp;</TD>
      <TD STYLE="width: 98%; text-align: justify"><FONT STYLE="font-size: 10pt">Pursuant to Rule 416(a) under the Securities Act of 1933, as amended (the &ldquo;Securities Act&rdquo;), this Registration Statement shall also cover any additional shares of the Registrant&rsquo;s common stock that become issuable in respect of the securities identified in the above table by reason of any stock dividend, stock split, recapitalization or other similar transaction effected without the receipt of consideration that increases the number of the Registrant&rsquo;s outstanding shares of common stock.</FONT></TD></TR>
  <TR STYLE="vertical-align: top">
      <TD STYLE="text-align: right"><FONT STYLE="font-size: 10pt">(2)</FONT></TD>
      <TD STYLE="text-align: right">&nbsp;</TD>
      <TD STYLE="text-align: justify"><FONT STYLE="font-size: 10pt">Represents additional shares of common stock reserved for issuance under the Registrant&rsquo;s Amended and Restated 2011 Equity Incentive Plan (the &ldquo;2011 Plan&rdquo;) resulting from stockholder approval of an amendment to the 2011 Plan on June 16, 2020.</FONT></TD></TR>
  <TR STYLE="vertical-align: top">
      <TD STYLE="text-align: right"><FONT STYLE="font-size: 10pt">(3)</FONT></TD>
      <TD>&nbsp;</TD>
      <TD STYLE="text-align: justify"><FONT STYLE="font-size: 10pt">Estimated in accordance with Rule 457(h) solely for the purpose of calculating the registration fee on the basis of $2.365, the average of high and low prices of the Registrant&rsquo;s common stock on the Nasdaq Capital Market on June 18, 2020.</FONT></TD></TR>
  </TABLE>
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-indent: 0.5in">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0"></P>
  
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  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0"></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-indent: 0.5in"></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0"><B>&nbsp;</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center"><B>EXPLANATORY NOTE</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center"><B>REGISTRATION OF ADDITIONAL SHARES PURSUANT
  TO GENERAL INSTRUCTION E</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-indent: 0.5in">CohBar, Inc. (the &ldquo;Registrant&rdquo;),
  is filing this Registration Statement on Form S-8 to register 4,000,000 additional shares of its common stock, $0.001 par value
  per share (&ldquo;Common Stock&rdquo;), for issuance under its Amended and Restated 2011 Equity Incentive Plan, as amended (the
  &ldquo;Plan&rdquo;). The Plan was originally adopted by the Registrant&rsquo;s board of directors (the &ldquo;Board&rdquo;) on
  November 3, 2014, and approved by the Registrant&rsquo;s stockholders on December 15, 2014. Amendments to increase the number
  of shares of Common Stock authorized under the Plan by 718,471 shares to 7,171,540 shares and by 2,828,460 shares to 10,000,000
  shares were approved by the Board on April 11, 2017 and April 20, 2018, respectively, and approved by the Registrant&rsquo;s stockholders
  on June 15, 2017 and June 19, 2018, respectively. A further amendment to increase the number of shares of Common Stock authorized
  under the Plan by 4,000,000 shares to a total of 14,000,000 shares was adopted by the Board on April 7, 2020 and was approved
  by the Registrant&rsquo;s stockholders on June 16, 2020. A total of 6,453,069 shares of Common Stock issuable or reserved for
  issuance under the Plan were previously registered on the Registrant&rsquo;s Form S-8 (<U><A HREF="http://www.sec.gov/Archives/edgar/data/1522602/000114420415040375/v414406_s8.htm" STYLE="-sec-extract: exhibit">No. 333-205412</A></U>), which was filed
  with the Securities and Exchange Commission and declared effective on July 1, 2015 and a total of 3,546,931 shares of Common Stock
  issuable or reserved for issuance under the Plan were previously registered on the Registrant&rsquo;s Form S-8 (<U><A HREF="http://www.sec.gov/Archives/edgar/data/1522602/000121390018009851/fs8072618_cohbarinc.htm">No. 333-226434</A></U>),
  which was filed with the Securities and Exchange Commission and declared effective on July 30, 2018, the contents of which are
  incorporated by reference herein. In accordance with the instructional note to Part I of Form S-8 as promulgated by the Commission,
  the information specified by Part I of Form S-8 has been omitted from this Registration Statement.</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center"><B>&nbsp;</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0"><B>&nbsp;</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center"><B>PART II</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center"><B>INFORMATION REQUIRED IN THE REGISTRATION
  STATEMENT</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-indent: 0.5in">&nbsp;</P>
  
  <TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
  <TR STYLE="vertical-align: top">
      <TD STYLE="width: 10%"><FONT STYLE="font-size: 10pt"><B>Item&nbsp;3.</B></FONT></TD>
      <TD STYLE="width: 90%"><FONT STYLE="font-size: 10pt"><B>Incorporation of Documents by Reference.</B></FONT></TD></TR>
  </TABLE>
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-indent: 48.95pt">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify; text-indent: 48.95pt">The following documents
  filed by the Registrant with the Commission pursuant to the Securities Act and the Securities Exchange Act of 1934, as amended
  (the &ldquo;Exchange Act&rdquo;), are incorporated herein by reference:</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify; text-indent: 0.5in">&nbsp;</P>
  
  <TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
  <TR>
      <TD STYLE="width: 4%; text-align: justify">&nbsp;</TD>
      <TD STYLE="vertical-align: top; width: 6%; text-align: justify"><FONT STYLE="font-size: 10pt">(a)</FONT></TD>
      <TD STYLE="vertical-align: top; width: 90%; text-align: justify"><FONT STYLE="font-size: 10pt">The Registrant&rsquo;s annual
      report on <U><A HREF="http://www.sec.gov/Archives/edgar/data/1522602/000121390020006115/f10k2019_cohbarinc.htm">Form 10-K</A></U> for the year ended December 31, 2019, as filed with the Commission on March 12, 2020, including
      information specifically incorporated into the Registrant&rsquo;s Form 10-K from the Registrant&rsquo;s definitive proxy statement
      on <U><A HREF="http://www.sec.gov/Archives/edgar/data/1522602/000121390020010351/def14a0420_cohbar.htm">Schedule 14A</A></U>, as filed with the Commission on April 29, 2020;</FONT></TD></TR>
  </TABLE>
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify; text-indent: 0.5in">&nbsp;</P>
  
  <TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
  <TR>
      <TD STYLE="width: 4%; text-align: justify">&nbsp;</TD>
      <TD STYLE="vertical-align: top; width: 6%; text-align: justify"><FONT STYLE="font-size: 10pt">(b)</FONT></TD>
      <TD STYLE="vertical-align: top; width: 90%; text-align: justify"><FONT STYLE="font-size: 10pt">All other reports filed pursuant to Section&nbsp;13(a) or 15(d) of the Exchange Act since the end of the fiscal year covered by the Registrant&rsquo;s Annual Report referred to in (a)&nbsp;above; and</FONT></TD></TR>
  <TR>
      <TD STYLE="text-align: justify">&nbsp;</TD>
      <TD STYLE="vertical-align: top; text-align: justify">&nbsp;</TD>
      <TD STYLE="vertical-align: top; text-align: justify">&nbsp;</TD></TR>
  <TR>
      <TD STYLE="text-align: justify">&nbsp;</TD>
      <TD STYLE="vertical-align: top; text-align: justify"><FONT STYLE="font-size: 10pt">(c)</FONT></TD>
      <TD STYLE="vertical-align: top; text-align: justify"><FONT STYLE="font-size: 10pt">The description of the Registrant&rsquo;s
      common stock contained in the Registrant&rsquo;s Registration Statement on <U><A HREF="http://www.sec.gov/Archives/edgar/data/1522602/000119312514445513/d839277d8a12g.htm" STYLE="-sec-extract: exhibit">Form 8-A</A></U> filed with the SEC on December 13, 2017, including any amendments or reports filed for the purpose of updating such description.</FONT></TD></TR>
  </TABLE>
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify; text-indent: 48.95pt">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; text-align: justify; text-indent: 48.95pt; margin-top: 0; margin-right: 0; margin-left: 0">All
  documents subsequently filed by the Registrant pursuant to Sections 13(a), 13(c), 14 and 15(d) of the Exchange Act, prior to the
  filing of a post-effective amendment which indicates that all securities offered hereby have been sold or which deregisters all
  securities then remaining unsold, shall be deemed to be incorporated by reference herein and to be a part hereof from the date
  of the filing of such documents;&nbsp;<I>provided</I>,&nbsp;<I>however</I>, that documents or information deemed to have been furnished
  and not filed in accordance with the rules of the Commission shall not be deemed incorporated by reference into this Registration
  Statement.&nbsp;Any statement contained in a document incorporated or deemed to be incorporated by reference herein shall be deemed
  to be modified or superseded for purposes of this Registration Statement to the extent that a statement contained in any subsequently
  filed document which also is deemed to be incorporated by reference herein modifies or supersedes such statement.&nbsp;</P>
  
  <!-- Field: Page; Sequence: 3; Value: 1 -->
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  <P STYLE="margin-top: 0; margin-bottom: 0">&nbsp;</P>
  
  <TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
  <TR STYLE="vertical-align: top">
      <TD STYLE="width: 10%"><FONT STYLE="font-size: 10pt"><B>Item&nbsp;8.</B></FONT></TD>
      <TD STYLE="width: 90%"><FONT STYLE="font-size: 10pt"><B>Exhibits.</B></FONT></TD></TR>
  </TABLE>
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-indent: 48.95pt">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-indent: 48.95pt">The following exhibits are filed herewith:</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-indent: 0.5in">&nbsp;</P>
  
  <TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
  <TR>
      <TD STYLE="padding-top: 0; text-align: center; width: 7%; padding-right: 0; padding-left: 0; text-indent: 0">&nbsp;</TD>
      <TD STYLE="vertical-align: bottom; width: 1%">&nbsp;</TD>
      <TD STYLE="width: 47%">&nbsp;</TD>
      <TD STYLE="vertical-align: bottom; width: 1%">&nbsp;</TD>
      <TD STYLE="width: 5%">&nbsp;</TD>
      <TD STYLE="vertical-align: bottom; width: 1%">&nbsp;</TD>
      <TD STYLE="width: 10%">&nbsp;</TD>
      <TD STYLE="vertical-align: bottom; width: 1%">&nbsp;</TD>
      <TD STYLE="width: 6%">&nbsp;</TD>
      <TD STYLE="vertical-align: bottom; width: 1%">&nbsp;</TD>
      <TD STYLE="width: 11%">&nbsp;</TD>
      <TD STYLE="vertical-align: bottom; width: 1%">&nbsp;</TD>
      <TD STYLE="width: 8%">&nbsp;</TD></TR>
  <TR STYLE="vertical-align: bottom">
      <TD ROWSPAN="2" STYLE="padding-top: 0; text-align: center; white-space: nowrap; padding-right: 0; padding-left: 0; text-indent: 0">
          <P STYLE="border-bottom: black 1pt solid; font: 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 0; text-align: center"><B>Exhibit<BR>
          Number</B></P></TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD COLSPAN="7" STYLE="white-space: nowrap">
          <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center; border-bottom: black 1pt solid"><B>Incorporated
          by Reference</B></P></TD>
      <TD>&nbsp;</TD>
      <TD ROWSPAN="2" STYLE="white-space: nowrap">
          <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center; border-bottom: black 1pt solid"><B>Filed<BR>
          Herewith</B></P></TD></TR>
  <TR STYLE="vertical-align: bottom">
      <TD>&nbsp;</TD>
      <TD STYLE="white-space: nowrap">
          <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center; border-bottom: black 1pt solid"><B>Exhibit Description</B></P></TD>
      <TD>&nbsp;</TD>
      <TD STYLE="white-space: nowrap">
          <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center; border-bottom: black 1pt solid"><B>Form</B></P></TD>
      <TD>&nbsp;</TD>
      <TD STYLE="white-space: nowrap">
          <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center; border-bottom: black 1pt solid"><B>File No.</B></P></TD>
      <TD>&nbsp;</TD>
      <TD STYLE="white-space: nowrap">
          <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center; border-bottom: black 1pt solid"><B>Exhibit</B></P></TD>
      <TD>&nbsp;</TD>
      <TD STYLE="white-space: nowrap">
          <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center; border-bottom: black 1pt solid"><B>Filing Date</B></P></TD>
      <TD>&nbsp;</TD></TR>
  <TR>
      <TD STYLE="padding-top: 0; text-align: center; padding-right: 0; padding-left: 0; text-indent: 0">&nbsp;</TD>
      <TD COLSPAN="2">&nbsp;</TD>
      <TD COLSPAN="2">&nbsp;</TD>
      <TD COLSPAN="2">&nbsp;</TD>
      <TD COLSPAN="2">&nbsp;</TD>
      <TD COLSPAN="2">&nbsp;</TD>
      <TD COLSPAN="2">&nbsp;</TD></TR>
  <TR STYLE="background-color: rgb(204,238,255)">
      <TD STYLE="padding-top: 0; white-space: nowrap; vertical-align: top; text-align: center; padding-right: 0; padding-left: 0; text-indent: 0"><FONT STYLE="font-size: 10pt">3.1</FONT></TD>
      <TD COLSPAN="2" STYLE="vertical-align: bottom"><FONT STYLE="font-size: 10pt"><A HREF="http://www.sec.gov/Archives/edgar/data/1522602/000119312514444009/d797268dex32.htm" STYLE="-sec-extract: exhibit">Third Amended and Restated Certificate of Incorporation of the Registrant.</A></FONT></TD>
      <TD STYLE="vertical-align: bottom">&nbsp;</TD>
      <TD STYLE="white-space: nowrap; vertical-align: bottom; text-align: right"><FONT STYLE="font-size: 10pt">S-1</FONT></TD>
      <TD STYLE="vertical-align: bottom; text-align: right">&nbsp;</TD>
      <TD STYLE="white-space: nowrap; vertical-align: bottom; text-align: right"><FONT STYLE="font-size: 10pt">333-200033</FONT></TD>
      <TD STYLE="vertical-align: bottom; text-align: right">&nbsp;</TD>
      <TD STYLE="white-space: nowrap; vertical-align: bottom; text-align: right"><FONT STYLE="font-size: 10pt">3.2</FONT></TD>
      <TD STYLE="vertical-align: bottom; text-align: right">&nbsp;</TD>
      <TD STYLE="white-space: nowrap; vertical-align: bottom; text-align: right"><FONT STYLE="font-size: 10pt">12/16/2014</FONT></TD>
      <TD STYLE="vertical-align: bottom">&nbsp;</TD>
      <TD STYLE="vertical-align: bottom">&nbsp;</TD></TR>
  <TR STYLE="background-color: White">
      <TD STYLE="padding-top: 0; text-align: center; padding-right: 0; padding-left: 0; text-indent: 0">&nbsp;</TD>
      <TD COLSPAN="2">&nbsp;</TD>
      <TD COLSPAN="2">&nbsp;</TD>
      <TD COLSPAN="2">&nbsp;</TD>
      <TD COLSPAN="2">&nbsp;</TD>
      <TD COLSPAN="2">&nbsp;</TD>
      <TD COLSPAN="2">&nbsp;</TD></TR>
  <TR STYLE="background-color: rgb(204,238,255)">
      <TD STYLE="padding-top: 0; white-space: nowrap; vertical-align: top; text-align: center; padding-right: 0; padding-left: 0; text-indent: 0"><FONT STYLE="font-size: 10pt">3.2</FONT></TD>
      <TD COLSPAN="2" STYLE="vertical-align: bottom"><FONT STYLE="font-size: 10pt"><A HREF="http://www.sec.gov/Archives/edgar/data/1522602/000121390020015254/ea122842ex3-1_cohbar.htm" STYLE="-sec-extract: exhibit">Certificate of Amendment to Third Amended and Restated Certificate of Incorporation of the Registrant.</A></FONT></TD>
      <TD STYLE="vertical-align: bottom">&nbsp;</TD>
      <TD STYLE="white-space: nowrap; vertical-align: bottom; text-align: right"><FONT STYLE="font-size: 10pt">8-K</FONT></TD>
      <TD STYLE="vertical-align: bottom; text-align: right">&nbsp;</TD>
      <TD STYLE="white-space: nowrap; vertical-align: bottom; text-align: right"><FONT STYLE="font-size: 10pt">000-38326</FONT></TD>
      <TD STYLE="vertical-align: bottom; text-align: right">&nbsp;</TD>
      <TD STYLE="white-space: nowrap; vertical-align: bottom; text-align: right"><FONT STYLE="font-size: 10pt">3.1</FONT></TD>
      <TD STYLE="vertical-align: bottom; text-align: right">&nbsp;</TD>
      <TD STYLE="white-space: nowrap; vertical-align: bottom; text-align: right"><FONT STYLE="font-size: 10pt">06/18/2020</FONT></TD>
      <TD STYLE="vertical-align: bottom">&nbsp;</TD>
      <TD STYLE="vertical-align: bottom">&nbsp;</TD></TR>
  <TR STYLE="background-color: White">
      <TD STYLE="padding-top: 0; white-space: nowrap; vertical-align: top; text-align: center; padding-right: 0; padding-left: 0; text-indent: 0">&nbsp;</TD>
      <TD STYLE="vertical-align: bottom">&nbsp;</TD>
      <TD STYLE="vertical-align: top">&nbsp;</TD>
      <TD STYLE="vertical-align: bottom">&nbsp;</TD>
      <TD STYLE="white-space: nowrap; vertical-align: bottom; text-align: right">&nbsp;</TD>
      <TD STYLE="vertical-align: bottom; text-align: right">&nbsp;</TD>
      <TD STYLE="white-space: nowrap; vertical-align: bottom; text-align: right">&nbsp;</TD>
      <TD STYLE="vertical-align: bottom; text-align: right">&nbsp;</TD>
      <TD STYLE="white-space: nowrap; vertical-align: bottom; text-align: right">&nbsp;</TD>
      <TD STYLE="vertical-align: bottom; text-align: right">&nbsp;</TD>
      <TD STYLE="white-space: nowrap; vertical-align: bottom; text-align: right">&nbsp;</TD>
      <TD STYLE="vertical-align: bottom">&nbsp;</TD>
      <TD STYLE="vertical-align: bottom">&nbsp;</TD></TR>
  <TR STYLE="background-color: rgb(204,238,255)">
      <TD STYLE="padding-top: 0; white-space: nowrap; vertical-align: top; text-align: center; padding-right: 0; padding-left: 0; text-indent: 0"><FONT STYLE="font-size: 10pt">3.2</FONT></TD>
      <TD COLSPAN="2" STYLE="vertical-align: bottom"><FONT STYLE="font-size: 10pt"><A HREF="http://www.sec.gov/Archives/edgar/data/1522602/000119312514444009/d797268dex34.htm" STYLE="-sec-extract: exhibit">Amended and Restated Bylaws of the Registrant.</A></FONT></TD>
      <TD STYLE="vertical-align: bottom">&nbsp;</TD>
      <TD STYLE="white-space: nowrap; vertical-align: bottom; text-align: right"><FONT STYLE="font-size: 10pt">S-1</FONT></TD>
      <TD STYLE="vertical-align: bottom; text-align: right">&nbsp;</TD>
      <TD STYLE="white-space: nowrap; vertical-align: bottom; text-align: right"><FONT STYLE="font-size: 10pt">333-200033</FONT></TD>
      <TD STYLE="vertical-align: bottom; text-align: right">&nbsp;</TD>
      <TD STYLE="white-space: nowrap; vertical-align: bottom; text-align: right"><FONT STYLE="font-size: 10pt">3.4</FONT></TD>
      <TD STYLE="vertical-align: bottom; text-align: right">&nbsp;</TD>
      <TD STYLE="white-space: nowrap; vertical-align: bottom; text-align: right"><FONT STYLE="font-size: 10pt">12/16/2014</FONT></TD>
      <TD STYLE="vertical-align: bottom">&nbsp;</TD>
      <TD STYLE="vertical-align: bottom">&nbsp;</TD></TR>
  <TR STYLE="background-color: White">
      <TD STYLE="padding-top: 0; text-align: center; padding-right: 0; padding-left: 0; text-indent: 0">&nbsp;</TD>
      <TD COLSPAN="2">&nbsp;</TD>
      <TD COLSPAN="2">&nbsp;</TD>
      <TD COLSPAN="2">&nbsp;</TD>
      <TD COLSPAN="2">&nbsp;</TD>
      <TD COLSPAN="2">&nbsp;</TD>
      <TD COLSPAN="2">&nbsp;</TD></TR>
  <TR STYLE="background-color: rgb(204,238,255)">
      <TD STYLE="padding-top: 0; white-space: nowrap; vertical-align: top; text-align: center; padding-right: 0; padding-left: 0; text-indent: 0"><FONT STYLE="font-size: 10pt">5.1</FONT></TD>
      <TD COLSPAN="2" STYLE="vertical-align: bottom"><FONT STYLE="font-size: 10pt"><A HREF="ea123242ex5-1_cohbar.htm" STYLE="-sec-extract: exhibit">Opinion of Fenwick &amp; West LLP.</A></FONT></TD>
      <TD STYLE="vertical-align: bottom">&nbsp;</TD>
      <TD STYLE="vertical-align: bottom">&nbsp;</TD>
      <TD STYLE="vertical-align: bottom">&nbsp;</TD>
      <TD STYLE="vertical-align: bottom">&nbsp;</TD>
      <TD STYLE="vertical-align: bottom">&nbsp;</TD>
      <TD STYLE="vertical-align: bottom">&nbsp;</TD>
      <TD STYLE="vertical-align: bottom">&nbsp;</TD>
      <TD STYLE="vertical-align: bottom">&nbsp;</TD>
      <TD STYLE="vertical-align: bottom">&nbsp;</TD>
      <TD STYLE="white-space: nowrap; vertical-align: bottom; text-align: center"><FONT STYLE="font-size: 10pt">X</FONT></TD></TR>
  <TR STYLE="background-color: White">
      <TD STYLE="padding-top: 0; text-align: center; padding-right: 0; padding-left: 0; text-indent: 0">&nbsp;</TD>
      <TD COLSPAN="2">&nbsp;</TD>
      <TD COLSPAN="2">&nbsp;</TD>
      <TD COLSPAN="2">&nbsp;</TD>
      <TD COLSPAN="2">&nbsp;</TD>
      <TD COLSPAN="2">&nbsp;</TD>
      <TD COLSPAN="2">&nbsp;</TD></TR>
  <TR STYLE="background-color: rgb(204,238,255)">
      <TD STYLE="padding-top: 0; white-space: nowrap; vertical-align: top; text-align: center; padding-right: 0; padding-left: 0; text-indent: 0"><FONT STYLE="font-size: 10pt">23.1</FONT></TD>
      <TD COLSPAN="2" STYLE="vertical-align: bottom"><A HREF="ea123242ex23-1_cohbar.htm"><FONT STYLE="font-size: 10pt">Consent of independent registered public accounting firm.</FONT></A></TD>
      <TD STYLE="vertical-align: bottom">&nbsp;</TD>
      <TD STYLE="vertical-align: bottom">&nbsp;</TD>
      <TD STYLE="vertical-align: bottom">&nbsp;</TD>
      <TD STYLE="vertical-align: bottom">&nbsp;</TD>
      <TD STYLE="vertical-align: bottom">&nbsp;</TD>
      <TD STYLE="vertical-align: bottom">&nbsp;</TD>
      <TD STYLE="vertical-align: bottom">&nbsp;</TD>
      <TD STYLE="vertical-align: bottom">&nbsp;</TD>
      <TD STYLE="vertical-align: bottom">&nbsp;</TD>
      <TD STYLE="white-space: nowrap; vertical-align: bottom; text-align: center"><FONT STYLE="font-size: 10pt">X</FONT></TD></TR>
  <TR STYLE="background-color: White">
      <TD STYLE="padding-top: 0; text-align: center; padding-right: 0; padding-left: 0; text-indent: 0">&nbsp;</TD>
      <TD COLSPAN="2">&nbsp;</TD>
      <TD COLSPAN="2">&nbsp;</TD>
      <TD COLSPAN="2">&nbsp;</TD>
      <TD COLSPAN="2">&nbsp;</TD>
      <TD COLSPAN="2">&nbsp;</TD>
      <TD COLSPAN="2">&nbsp;</TD></TR>
  <TR STYLE="background-color: rgb(204,238,255)">
      <TD STYLE="padding-top: 0; white-space: nowrap; vertical-align: top; text-align: center; padding-right: 0; padding-left: 0; text-indent: 0"><FONT STYLE="font-size: 10pt">23.2</FONT></TD>
      <TD COLSPAN="2" STYLE="vertical-align: bottom"><FONT STYLE="font-size: 10pt"><A HREF="ea123242ex5-1_cohbar.htm" STYLE="-sec-extract: exhibit">Consent of Fenwick &amp; West LLP (contained in Exhibit&nbsp;5.1).</A></FONT></TD>
      <TD STYLE="vertical-align: bottom">&nbsp;</TD>
      <TD STYLE="vertical-align: bottom">&nbsp;</TD>
      <TD STYLE="vertical-align: bottom">&nbsp;</TD>
      <TD STYLE="vertical-align: bottom">&nbsp;</TD>
      <TD STYLE="vertical-align: bottom">&nbsp;</TD>
      <TD STYLE="vertical-align: bottom">&nbsp;</TD>
      <TD STYLE="vertical-align: bottom">&nbsp;</TD>
      <TD STYLE="vertical-align: bottom">&nbsp;</TD>
      <TD STYLE="vertical-align: bottom">&nbsp;</TD>
      <TD STYLE="white-space: nowrap; vertical-align: bottom; text-align: center"><FONT STYLE="font-size: 10pt">X</FONT></TD></TR>
  <TR STYLE="background-color: White">
      <TD STYLE="padding-top: 0; text-align: center; padding-right: 0; padding-left: 0; text-indent: 0">&nbsp;</TD>
      <TD COLSPAN="2">&nbsp;</TD>
      <TD COLSPAN="2">&nbsp;</TD>
      <TD COLSPAN="2">&nbsp;</TD>
      <TD COLSPAN="2">&nbsp;</TD>
      <TD COLSPAN="2">&nbsp;</TD>
      <TD COLSPAN="2">&nbsp;</TD></TR>
  <TR STYLE="background-color: rgb(204,238,255)">
      <TD STYLE="padding-top: 0; white-space: nowrap; vertical-align: top; text-align: center; padding-right: 0; padding-left: 0; text-indent: 0"><FONT STYLE="font-size: 10pt">24.1</FONT></TD>
      <TD COLSPAN="2" STYLE="vertical-align: bottom"><FONT STYLE="font-size: 10pt"><A HREF="#a_101">Power of Attorney (included on the signature page to this Registration Statement).</A></FONT></TD>
      <TD STYLE="vertical-align: bottom">&nbsp;</TD>
      <TD STYLE="vertical-align: bottom">&nbsp;</TD>
      <TD STYLE="vertical-align: bottom">&nbsp;</TD>
      <TD STYLE="vertical-align: bottom">&nbsp;</TD>
      <TD STYLE="vertical-align: bottom">&nbsp;</TD>
      <TD STYLE="vertical-align: bottom">&nbsp;</TD>
      <TD STYLE="vertical-align: bottom">&nbsp;</TD>
      <TD STYLE="vertical-align: bottom">&nbsp;</TD>
      <TD STYLE="vertical-align: bottom">&nbsp;</TD>
      <TD STYLE="white-space: nowrap; vertical-align: bottom; text-align: center"><FONT STYLE="font-size: 10pt">X</FONT></TD></TR>
  <TR STYLE="background-color: White">
      <TD STYLE="padding-top: 0; text-align: center; padding-right: 0; padding-left: 0; text-indent: 0">&nbsp;</TD>
      <TD COLSPAN="2">&nbsp;</TD>
      <TD COLSPAN="2">&nbsp;</TD>
      <TD COLSPAN="2">&nbsp;</TD>
      <TD COLSPAN="2">&nbsp;</TD>
      <TD COLSPAN="2">&nbsp;</TD>
      <TD COLSPAN="2">&nbsp;</TD></TR>
  <TR STYLE="background-color: rgb(204,238,255)">
      <TD STYLE="padding-top: 0; white-space: nowrap; vertical-align: top; text-align: center; padding-right: 0; padding-left: 0; text-indent: 0"><FONT STYLE="font-size: 10pt">99.1</FONT></TD>
      <TD COLSPAN="2" STYLE="vertical-align: bottom"><FONT STYLE="font-size: 10pt"><A HREF="http://www.sec.gov/Archives/edgar/data/1522602/000119312515004219/d849066dex32.htm" STYLE="-sec-extract: exhibit">Amended and Restated 2011 Equity Incentive Plan.</A></FONT></TD>
      <TD STYLE="vertical-align: bottom">&nbsp;</TD>
      <TD STYLE="white-space: nowrap; vertical-align: bottom; text-align: right"><FONT STYLE="font-size: 10pt">8-K</FONT></TD>
      <TD STYLE="vertical-align: bottom; text-align: right">&nbsp;</TD>
      <TD STYLE="white-space: nowrap; vertical-align: bottom; text-align: right"><FONT STYLE="font-size: 10pt">000-55334</FONT></TD>
      <TD STYLE="vertical-align: bottom">&nbsp;</TD>
      <TD STYLE="white-space: nowrap; vertical-align: bottom; text-align: right"><FONT STYLE="font-size: 10pt">10.1</FONT></TD>
      <TD STYLE="vertical-align: bottom">&nbsp;</TD>
      <TD STYLE="white-space: nowrap; vertical-align: bottom; text-align: right"><FONT STYLE="font-size: 10pt">01/08/2015</FONT></TD>
      <TD STYLE="vertical-align: bottom">&nbsp;</TD>
      <TD STYLE="vertical-align: bottom">&nbsp;</TD></TR>
  <TR STYLE="background-color: White">
      <TD STYLE="padding-top: 0; text-align: center; padding-right: 0; padding-left: 0; text-indent: 0">&nbsp;</TD>
      <TD COLSPAN="2">&nbsp;</TD>
      <TD COLSPAN="2">&nbsp;</TD>
      <TD COLSPAN="2">&nbsp;</TD>
      <TD COLSPAN="2">&nbsp;</TD>
      <TD COLSPAN="2">&nbsp;</TD>
      <TD COLSPAN="2">&nbsp;</TD></TR>
  <TR STYLE="background-color: rgb(204,238,255)">
      <TD STYLE="padding-top: 0; text-align: center; padding-right: 0; padding-left: 0; text-indent: 0"><FONT STYLE="font-size: 10pt">99.2</FONT></TD>
      <TD COLSPAN="2"><FONT STYLE="font-size: 10pt"><A HREF="http://www.sec.gov/Archives/edgar/data/1522602/000119312514403939/d797268dex102.htm" STYLE="-sec-extract: exhibit">Form of Option Agreement.</A></FONT></TD>
      <TD COLSPAN="2" STYLE="text-align: right"><FONT STYLE="font-size: 10pt">S-1</FONT></TD>
      <TD COLSPAN="2" STYLE="text-align: right"><FONT STYLE="font-size: 10pt">333-200033</FONT></TD>
      <TD COLSPAN="2" STYLE="text-align: right"><FONT STYLE="font-size: 10pt">10.2</FONT></TD>
      <TD COLSPAN="2" STYLE="text-align: right"><FONT STYLE="font-size: 10pt">11/07/2014</FONT></TD>
      <TD COLSPAN="2">&nbsp;</TD></TR>
  <TR STYLE="background-color: White">
      <TD STYLE="padding-top: 0; text-align: center; padding-right: 0; padding-left: 0; text-indent: 0">&nbsp;</TD>
      <TD COLSPAN="2">&nbsp;</TD>
      <TD COLSPAN="2">&nbsp;</TD>
      <TD COLSPAN="2">&nbsp;</TD>
      <TD COLSPAN="2">&nbsp;</TD>
      <TD COLSPAN="2">&nbsp;</TD>
      <TD COLSPAN="2">&nbsp;</TD></TR>
  <TR STYLE="background-color: rgb(204,238,255)">
      <TD STYLE="padding-top: 0; text-align: center; padding-right: 0; padding-left: 0; text-indent: 0"><FONT STYLE="font-size: 10pt">99.3</FONT></TD>
      <TD COLSPAN="2"><FONT STYLE="font-size: 10pt"><A HREF="http://www.sec.gov/Archives/edgar/data/1522602/000121390017008681/f10q0617ex10i_cohbarinc.htm" STYLE="-sec-extract: exhibit">First Amendment to Amended and Restated 2011 Equity Incentive Plan.</A></FONT></TD>
      <TD COLSPAN="2" STYLE="text-align: right"><FONT STYLE="font-size: 10pt">10-Q</FONT></TD>
      <TD COLSPAN="2" STYLE="text-align: right"><FONT STYLE="font-size: 10pt">000-55334</FONT></TD>
      <TD COLSPAN="2" STYLE="text-align: right"><FONT STYLE="font-size: 10pt">10.1</FONT></TD>
      <TD COLSPAN="2" STYLE="text-align: right"><FONT STYLE="font-size: 10pt">08/14/2017</FONT></TD>
      <TD COLSPAN="2">&nbsp;</TD></TR>
  <TR STYLE="background-color: White">
      <TD STYLE="padding-top: 0; text-align: center; padding-right: 0; padding-left: 0; text-indent: 0">&nbsp;</TD>
      <TD COLSPAN="2">&nbsp;</TD>
      <TD COLSPAN="2" STYLE="text-align: right">&nbsp;</TD>
      <TD COLSPAN="2" STYLE="text-align: right">&nbsp;</TD>
      <TD COLSPAN="2" STYLE="text-align: right">&nbsp;</TD>
      <TD COLSPAN="2" STYLE="text-align: right">&nbsp;</TD>
      <TD COLSPAN="2">&nbsp;</TD></TR>
  <TR STYLE="background-color: rgb(204,238,255)">
      <TD STYLE="padding-top: 0; text-align: center; padding-right: 0; padding-left: 0; text-indent: 0"><FONT STYLE="font-size: 10pt">99.4</FONT></TD>
      <TD COLSPAN="2"><FONT STYLE="font-size: 10pt"><A HREF="http://www.sec.gov/Archives/edgar/data/1522602/000121390018009851/fs8072618ex99-4_cohbarinc.htm" STYLE="-sec-extract: exhibit">Second Amendment to Amended and Restated 2011 Equity Incentive Plan.</A></FONT></TD>
      <TD COLSPAN="2" STYLE="text-align: right"><FONT STYLE="font-size: 10pt">S-8</FONT></TD>
      <TD COLSPAN="2" STYLE="text-align: right"><FONT STYLE="font-size: 10pt">333-226434</FONT></TD>
      <TD COLSPAN="2" STYLE="text-align: right"><FONT STYLE="font-size: 10pt">99.4</FONT></TD>
      <TD COLSPAN="2" STYLE="text-align: right"><FONT STYLE="font-size: 10pt">07/30/2018</FONT></TD>
      <TD COLSPAN="2">&nbsp;</TD></TR>
  <TR STYLE="background-color: White">
      <TD STYLE="padding-top: 0; text-align: center; padding-right: 0; padding-left: 0; text-indent: 0">&nbsp;</TD>
      <TD COLSPAN="2">&nbsp;</TD>
      <TD COLSPAN="2" STYLE="text-align: right">&nbsp;</TD>
      <TD COLSPAN="2" STYLE="text-align: right">&nbsp;</TD>
      <TD COLSPAN="2" STYLE="text-align: right">&nbsp;</TD>
      <TD COLSPAN="2" STYLE="text-align: right">&nbsp;</TD>
      <TD COLSPAN="2">&nbsp;</TD></TR>
  <TR STYLE="background-color: rgb(204,238,255)">
      <TD STYLE="padding-top: 0; text-align: center; padding-right: 0; padding-left: 0; text-indent: 0"><FONT STYLE="font-size: 10pt">99.5</FONT></TD>
      <TD COLSPAN="2"><FONT STYLE="font-size: 10pt"><A HREF="ea123242ex99-5_cohbar.htm" STYLE="-sec-extract: exhibit">Third Amendment to Amended and Restated 2011 Equity Incentive Plan.</A></FONT></TD>
      <TD COLSPAN="2" STYLE="text-align: right">&nbsp;</TD>
      <TD COLSPAN="2" STYLE="text-align: right">&nbsp;</TD>
      <TD COLSPAN="2" STYLE="text-align: right">&nbsp;</TD>
      <TD COLSPAN="2" STYLE="text-align: right">&nbsp;</TD>
      <TD COLSPAN="2" STYLE="text-align: center"><FONT STYLE="font-size: 10pt">X</FONT></TD></TR>
  </TABLE>
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>
  
  <!-- Field: Page; Sequence: 4; Value: 1 -->
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      <DIV STYLE="page-break-before: always; margin-top: 6pt; margin-bottom: 6pt"><P STYLE="margin: 0pt">&nbsp;</P></DIV>
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  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0"></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0"></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0"><B>&nbsp;</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center"><B>SIGNATURES</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify; text-indent: 0.5in">Pursuant to the requirements
  of the Securities Act, the Registrant certifies that it has reasonable grounds to believe that it meets all of the requirements
  for filing on Form S-8 and has duly caused this Registration Statement to be signed on its behalf by the undersigned, thereunto
  duly authorized, in the City of Menlo Park, State of California, on this 23rd day of June, 2020.</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-indent: 0.5in">&nbsp;</P>
  
  <TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
  <TR STYLE="vertical-align: top">
      <TD>&nbsp;</TD>
      <TD COLSPAN="3"><FONT STYLE="font-size: 10pt"><B>COHBAR, INC.</B></FONT></TD></TR>
  <TR>
      <TD STYLE="vertical-align: top">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD COLSPAN="2">&nbsp;</TD></TR>
  <TR>
      <TD STYLE="vertical-align: top; width: 52%">&nbsp;</TD>
      <TD STYLE="vertical-align: top; width: 2%"><FONT STYLE="font-size: 10pt">By:</FONT></TD>
      <TD STYLE="vertical-align: bottom; width: 1%">&nbsp;</TD>
      <TD STYLE="vertical-align: top; width: 45%">
          <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; border-bottom: black 0.75pt solid">/s/ Jeffrey Biunno</P></TD></TR>
  <TR>
      <TD STYLE="vertical-align: top">&nbsp;</TD>
      <TD STYLE="vertical-align: top">&nbsp;</TD>
      <TD STYLE="vertical-align: bottom">&nbsp;</TD>
      <TD STYLE="vertical-align: top"><FONT STYLE="font-size: 10pt">Jeffrey Biunno</FONT></TD></TR>
  <TR>
      <TD STYLE="vertical-align: top">&nbsp;</TD>
      <TD STYLE="vertical-align: top">&nbsp;</TD>
      <TD STYLE="vertical-align: bottom">&nbsp;</TD>
      <TD STYLE="vertical-align: top"><FONT STYLE="font-size: 10pt">Principal Financial Officer</FONT></TD></TR>
  </TABLE>
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center"><B>&nbsp;</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center"></P>
  
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      <DIV STYLE="page-break-before: always; margin-top: 6pt; margin-bottom: 6pt"><P STYLE="margin: 0pt">&nbsp;</P></DIV>
      <!-- Field: /Page -->
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center"><B>&nbsp;</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center"><B></B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center"><B><A NAME="a_101" TITLE="power of att"></A>POWER OF ATTORNEY</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify; text-indent: 0.5in"><B>KNOW ALL PERSONS BY
  THESE PRESENTS</B>, that each person whose signature appears below hereby constitutes and appoints Steven Engle and Jeffrey F.
  Biunno, and each of them, as his true and lawful attorney-in-fact and agent with full power of substitution, for him in any and
  all capacities, to sign any and all amendments (including post-effective amendments) to this Registration Statement on Form S-8,
  and to file the same, with all exhibits thereto and other documents in connection therewith, with the Securities and Exchange Commission,
  granting unto said attorney-in-fact and agent full power and authority to do and perform each and every act and thing requisite
  and necessary to be done in connection therewith, as fully for all intents and purposes as he or she might or could do in person,
  hereby ratifying and confirming all that said attorney-in-fact and agent, or his or her substitute, may lawfully do or cause to
  be done by virtue hereof.</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify; text-indent: 48.95pt">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify; text-indent: 48.95pt">Pursuant to the requirements
  of the Securities Act, this Registration Statement has been signed by the following persons in the capacities and on the date indicated.</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-indent: 48.95pt">&nbsp;</P>
  
  <TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
  <TR STYLE="vertical-align: top">
      <TD STYLE="width: 32%; text-align: center">&nbsp;</TD>
      <TD STYLE="width: 1%">&nbsp;</TD>
      <TD STYLE="width: 51%">&nbsp;</TD>
      <TD STYLE="width: 1%">&nbsp;</TD>
      <TD STYLE="width: 15%; text-align: center">&nbsp;</TD></TR>
  <TR STYLE="vertical-align: top">
      <TD STYLE="border-bottom: black 1pt solid; text-align: center"><FONT STYLE="font-size: 10pt"><B>Name</B></FONT></TD>
      <TD>&nbsp;</TD>
      <TD STYLE="border-bottom: black 1pt solid; text-align: center"><FONT STYLE="font-size: 10pt"><B>Title</B></FONT></TD>
      <TD>&nbsp;</TD>
      <TD STYLE="border-bottom: black 1pt solid; text-align: center"><FONT STYLE="font-size: 10pt"><B>Date</B></FONT></TD></TR>
  <TR STYLE="vertical-align: top">
      <TD STYLE="text-align: center">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD STYLE="text-align: center">&nbsp;</TD></TR>
  <TR STYLE="vertical-align: top">
      <TD><FONT STYLE="font-size: 10pt">Principal Executive Officer:</FONT></TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD STYLE="text-align: center">&nbsp;</TD></TR>
  <TR STYLE="vertical-align: top">
      <TD STYLE="text-align: center">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD STYLE="text-align: center">&nbsp;</TD></TR>
  <TR>
      <TD STYLE="vertical-align: bottom; border-bottom: black 1pt solid; text-align: center"><FONT STYLE="font-size: 10pt">/s/ Steven Engle</FONT></TD>
      <TD STYLE="vertical-align: top">&nbsp;</TD>
      <TD STYLE="vertical-align: top"><FONT STYLE="font-size: 10pt">Principal Executive Officer, Director</FONT></TD>
      <TD STYLE="vertical-align: top">&nbsp;</TD>
      <TD STYLE="vertical-align: top; text-align: center"><FONT STYLE="font-size: 10pt">June 23, 2020</FONT></TD></TR>
  <TR>
      <TD STYLE="vertical-align: bottom; text-align: center"><FONT STYLE="font-size: 10pt">Steven Engle</FONT></TD>
      <TD STYLE="vertical-align: top">&nbsp;</TD>
      <TD STYLE="vertical-align: top">&nbsp;</TD>
      <TD STYLE="vertical-align: top">&nbsp;</TD>
      <TD STYLE="vertical-align: top; text-align: center">&nbsp;</TD></TR>
  <TR STYLE="vertical-align: top">
      <TD STYLE="text-align: center">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD STYLE="text-align: center">&nbsp;</TD></TR>
  <TR STYLE="vertical-align: top">
      <TD><FONT STYLE="font-size: 10pt">Principal Financial Officer and</FONT></TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD STYLE="text-align: center">&nbsp;</TD></TR>
  <TR STYLE="vertical-align: top">
      <TD><FONT STYLE="font-size: 10pt">Principal Accounting Officer:</FONT></TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD STYLE="text-align: center">&nbsp;</TD></TR>
  <TR STYLE="vertical-align: top">
      <TD STYLE="text-align: center">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD STYLE="text-align: center">&nbsp;</TD></TR>
  <TR>
      <TD STYLE="vertical-align: bottom; border-bottom: black 1pt solid; text-align: center"><FONT STYLE="font-size: 10pt">/s/&nbsp;Jeffrey F. Biunno</FONT></TD>
      <TD STYLE="vertical-align: top">&nbsp;</TD>
      <TD STYLE="vertical-align: top"><FONT STYLE="font-size: 10pt">Principal Financial Officer, Principal Accounting Officer</FONT></TD>
      <TD STYLE="vertical-align: top">&nbsp;</TD>
      <TD STYLE="vertical-align: top; text-align: center"><FONT STYLE="font-size: 10pt">June 23, 2020</FONT></TD></TR>
  <TR>
      <TD STYLE="vertical-align: bottom; text-align: center"><FONT STYLE="font-size: 10pt">Jeffrey F. Biunno</FONT></TD>
      <TD STYLE="vertical-align: top">&nbsp;</TD>
      <TD STYLE="vertical-align: top">&nbsp;</TD>
      <TD STYLE="vertical-align: top">&nbsp;</TD>
      <TD STYLE="vertical-align: top; text-align: center">&nbsp;</TD></TR>
  <TR STYLE="vertical-align: top">
      <TD STYLE="text-align: center">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD STYLE="text-align: center">&nbsp;</TD></TR>
  <TR>
      <TD STYLE="vertical-align: bottom; border-bottom: black 1pt solid; text-align: center"><FONT STYLE="font-size: 10pt">/s/&nbsp;Albion J. Fitzgerald</FONT></TD>
      <TD STYLE="vertical-align: top">&nbsp;</TD>
      <TD STYLE="vertical-align: top"><FONT STYLE="font-size: 10pt">Chairman of the Board of Directors</FONT></TD>
      <TD STYLE="vertical-align: top">&nbsp;</TD>
      <TD STYLE="vertical-align: top; text-align: center"><FONT STYLE="font-size: 10pt">June 23, 2020</FONT></TD></TR>
  <TR>
      <TD STYLE="vertical-align: bottom; text-align: center"><FONT STYLE="font-size: 10pt">Albion J. Fitzgerald</FONT></TD>
      <TD STYLE="vertical-align: top">&nbsp;</TD>
      <TD STYLE="vertical-align: top">&nbsp;</TD>
      <TD STYLE="vertical-align: top">&nbsp;</TD>
      <TD STYLE="vertical-align: top; text-align: center">&nbsp;</TD></TR>
  <TR STYLE="vertical-align: top">
      <TD STYLE="text-align: center">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD STYLE="text-align: center">&nbsp;</TD></TR>
  <TR>
      <TD STYLE="vertical-align: bottom; border-bottom: black 1pt solid; text-align: center"><FONT STYLE="font-size: 10pt">/s/ Jon Stern</FONT></TD>
      <TD STYLE="vertical-align: top">&nbsp;</TD>
      <TD STYLE="vertical-align: top"><FONT STYLE="font-size: 10pt">Director</FONT></TD>
      <TD STYLE="vertical-align: top">&nbsp;</TD>
      <TD STYLE="vertical-align: top; text-align: center"><FONT STYLE="font-size: 10pt">June 23, 2020</FONT></TD></TR>
  <TR>
      <TD STYLE="vertical-align: bottom; text-align: center"><FONT STYLE="font-size: 10pt">Jon Stern</FONT></TD>
      <TD STYLE="vertical-align: top">&nbsp;</TD>
      <TD STYLE="vertical-align: top">&nbsp;</TD>
      <TD STYLE="vertical-align: top">&nbsp;</TD>
      <TD STYLE="vertical-align: top; text-align: center">&nbsp;</TD></TR>
  <TR STYLE="vertical-align: top">
      <TD STYLE="text-align: center">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD STYLE="text-align: center">&nbsp;</TD></TR>
  <TR>
      <TD STYLE="vertical-align: bottom; border-bottom: black 1pt solid; text-align: center"><FONT STYLE="font-size: 10pt">/s/&nbsp;Nir Barzilai</FONT></TD>
      <TD STYLE="vertical-align: top">&nbsp;</TD>
      <TD STYLE="vertical-align: top"><FONT STYLE="font-size: 10pt">Director</FONT></TD>
      <TD STYLE="vertical-align: top">&nbsp;</TD>
      <TD STYLE="vertical-align: top; text-align: center"><FONT STYLE="font-size: 10pt">June 23, 2020</FONT></TD></TR>
  <TR>
      <TD STYLE="vertical-align: bottom; text-align: center"><FONT STYLE="font-size: 10pt">Nir Barzilai</FONT></TD>
      <TD STYLE="vertical-align: top">&nbsp;</TD>
      <TD STYLE="vertical-align: top">&nbsp;</TD>
      <TD STYLE="vertical-align: top">&nbsp;</TD>
      <TD STYLE="vertical-align: top; text-align: center">&nbsp;</TD></TR>
  <TR STYLE="vertical-align: top">
      <TD STYLE="text-align: center">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD STYLE="text-align: center">&nbsp;</TD></TR>
  <TR>
      <TD STYLE="vertical-align: bottom; border-bottom: black 1pt solid; text-align: center"><FONT STYLE="font-size: 10pt">/s/&nbsp;Pinchas Cohen</FONT></TD>
      <TD STYLE="vertical-align: top">&nbsp;</TD>
      <TD STYLE="vertical-align: top"><FONT STYLE="font-size: 10pt">Director</FONT></TD>
      <TD STYLE="vertical-align: top">&nbsp;</TD>
      <TD STYLE="vertical-align: top; text-align: center"><FONT STYLE="font-size: 10pt">June 23, 2020</FONT></TD></TR>
  <TR>
      <TD STYLE="vertical-align: bottom; text-align: center"><FONT STYLE="font-size: 10pt">Pinchas Cohen</FONT></TD>
      <TD STYLE="vertical-align: top">&nbsp;</TD>
      <TD STYLE="vertical-align: top">&nbsp;</TD>
      <TD STYLE="vertical-align: top">&nbsp;</TD>
      <TD STYLE="vertical-align: top; text-align: center">&nbsp;</TD></TR>
  <TR STYLE="vertical-align: top">
      <TD STYLE="text-align: center">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD STYLE="text-align: center">&nbsp;</TD></TR>
  <TR STYLE="vertical-align: top">
      <TD STYLE="border-bottom: Black 1pt solid; text-align: center"><FONT STYLE="font-size: 10pt">/s/ Phyllis Gardner</FONT></TD>
      <TD>&nbsp;</TD>
      <TD><FONT STYLE="font-size: 10pt">Director</FONT></TD>
      <TD>&nbsp;</TD>
      <TD STYLE="text-align: center"><FONT STYLE="font-size: 10pt">June 23, 2020</FONT></TD></TR>
  <TR STYLE="vertical-align: top">
      <TD STYLE="text-align: center"><FONT STYLE="font-size: 10pt">Phyllis Gardner</FONT></TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD STYLE="text-align: center">&nbsp;</TD></TR>
  <TR STYLE="vertical-align: top">
      <TD STYLE="text-align: center">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD STYLE="text-align: center">&nbsp;</TD></TR>
  <TR STYLE="vertical-align: top">
      <TD STYLE="border-bottom: Black 1pt solid; text-align: center"><FONT STYLE="font-size: 10pt">/s/ David Greenwood</FONT></TD>
      <TD>&nbsp;</TD>
      <TD><FONT STYLE="font-size: 10pt">Director</FONT></TD>
      <TD>&nbsp;</TD>
      <TD STYLE="text-align: center"><FONT STYLE="font-size: 10pt">June 23, 2020</FONT></TD></TR>
  <TR STYLE="vertical-align: top">
      <TD STYLE="text-align: center"><FONT STYLE="font-size: 10pt">David Greenwood</FONT></TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD STYLE="text-align: center">&nbsp;</TD></TR>
  <TR STYLE="vertical-align: top">
      <TD STYLE="text-align: center">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD STYLE="text-align: center">&nbsp;</TD></TR>
  <TR STYLE="vertical-align: top">
      <TD STYLE="border-bottom: black 1pt solid; text-align: center"><FONT STYLE="font-size: 10pt">/s/ Misha Petkevich</FONT></TD>
      <TD>&nbsp;</TD>
      <TD><FONT STYLE="font-size: 10pt">Director</FONT></TD>
      <TD>&nbsp;</TD>
      <TD STYLE="text-align: center"><FONT STYLE="font-size: 10pt">June 23, 2020</FONT></TD></TR>
  <TR STYLE="vertical-align: top">
      <TD STYLE="text-align: center"><FONT STYLE="font-size: 10pt">Misha Petkevich</FONT></TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD STYLE="text-align: center">&nbsp;</TD></TR>
  </TABLE>
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>
  
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  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0"></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-indent: 48.95pt">&nbsp;</P>
  
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metadata_filer: {"company-data": {"conformed-name": "CohBar, Inc.", "cik": "0001522602", "assigned-sic": "2834", "irs-number": "261299952", "state-of-incorporation": "DE", "fiscal-year-end": "1231"}, "filing-values": {"form-type": "S-8", "act": "33", "file-number": "333-239387", "film-number": "20981983"}, "business-address": {"street1": "1455 ADAMS DRIVE, SUITE 2050", "street2": "MENLO BUSINESS PARK", "city": "MENLO PARK", "state": "CA", "zip": "94025", "phone": "(650) 446-7888"}, "mail-address": {"street1": "1455 ADAMS DRIVE, SUITE 2050", "street2": "MENLO BUSINESS PARK", "city": "MENLO PARK", "state": "CA", "zip": "94025"}, "former-company": {"former-conformed-name": "Cohbar, Inc.", "date-changed": "20110606"}}
text: As filed with the Securities and Exchange
  Commission on June 23, 2020
  Registration
  No.  333-
  UNITED STATES
  SECURITIES AND EXCHANGE COMMISSION
  WASHINGTON, D.C. 20549
  FORM S-8
  REGISTRATION STATEMENT
  UNDER
  THE SECURITIES ACT OF 1933
  COHBAR, INC.
  (Exact name of Registrant as specified in
  its charter)
  Delaware
  26-1299952
  (State or other jurisdiction of
  incorporation or organization)
  (I.R.S. Employer
  Identification Number)
  1455 Adams Drive, Suite 2050
  Menlo Park, CA 94025
  (650) 446-7888
  (Address, including zip code, of principal
  executive offices)
  Amended and Restated 2011 Equity Incentive
  Plan
  (Full title of the plan)
  Steven Engle
  Chief Executive Officer
  CohBar, Inc.
  1455 Adams Drive, Suite 2050
  Menlo Park, CA 94025
  (650) 446-7888
  (Name and address, and telephone number,
  including area code, of agent for service)
  Please send copies of all communications
  to:
  Amanda Rose, Esq.
  Chelsea Anderson, Esq.
  Fenwick & West LLP
  1191 Second Avenue, Floor 10
  Seattle, WA 98101
  (206) 389-4510
  Indicate by check mark whether the Registrant is a large
  accelerated filer, an accelerated filer, a non-accelerated filer, a smaller reporting company, or an emerging growth company. See
  the definitions of "large accelerated filer," "accelerated filer," "smaller reporting company,"
  and "emerging growth company" in Rule 12b-2 of the Exchange Act.
  Large accelerated filer
  ☐
  Accelerated filer
  ☐
  Non-accelerated filer
  ☒
  Smaller reporting company
  ☒
  Emerging growth company
  ☒
  If an emerging growth company, indicate by check mark if
  the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting
  standards provided pursuant to Section 7(a)(2)(B) of the Securities Act.
  ☐
  CALCULATION OF REGISTRATION FEE
  Title of
  Securities to be Registered
  Amount
  to be
  Registered
  (1)
  Proposed
  Maximum
  Offering Price
  Per Share
  (3)
  Proposed
  Maximum
  Aggregate
  Offering Price
  Amount of
  Registration Fee
  Common Stock, par value $0.001 per share
  — To be issued under the Amended and Restated 2011 Equity Incentive Plan
  4,000,000(2)
  $2.365
  $9,460,000
  $1,228
  (1)
  Pursuant to Rule 416(a) under the Securities Act of 1933, as amended (the "Securities Act"), this Registration Statement shall also cover any additional shares of the Registrant's common stock that become issuable in respect of the securities identified in the above table by reason of any stock dividend, stock split, recapitalization or other similar transaction effected without the receipt of consideration that increases the number of the Registrant's outstanding shares of common stock.
  (2)
  Represents additional shares of common stock reserved for issuance under the Registrant's Amended and Restated 2011 Equity Incentive Plan (the "2011 Plan") resulting from stockholder approval of an amendment to the 2011 Plan on June 16, 2020.
  (3)
  Estimated in accordance with Rule 457(h) solely for the purpose of calculating the registration fee on the basis of $2.365, the average of high and low prices of the Registrant's common stock on the Nasdaq Capital Market on June 18, 2020.
  1
  EXPLANATORY NOTE
  REGISTRATION OF ADDITIONAL SHARES PURSUANT
  TO GENERAL INSTRUCTION E
  CohBar, Inc. (the "Registrant"),
  is filing this Registration Statement on Form S-8 to register 4,000,000 additional shares of its common stock, $0.001 par value
  per share ("Common Stock"), for issuance under its Amended and Restated 2011 Equity Incentive Plan, as amended (the
  "Plan"). The Plan was originally adopted by the Registrant's board of directors (the "Board") on
  November 3, 2014, and approved by the Registrant's stockholders on December 15, 2014. Amendments to increase the number
  of shares of Common Stock authorized under the Plan by 718,471 shares to 7,171,540 shares and by 2,828,460 shares to 10,000,000
  shares were approved by the Board on April 11, 2017 and April 20, 2018, respectively, and approved by the Registrant's stockholders
  on June 15, 2017 and June 19, 2018, respectively. A further amendment to increase the number of shares of Common Stock authorized
  under the Plan by 4,000,000 shares to a total of 14,000,000 shares was adopted by the Board on April 7, 2020 and was approved
  by the Registrant's stockholders on June 16, 2020. A total of 6,453,069 shares of Common Stock issuable or reserved for
  issuance under the Plan were previously registered on the Registrant's Form S-8 (
  No. 333-205412
  ), which was filed
  with the Securities and Exchange Commission and declared effective on July 1, 2015 and a total of 3,546,931 shares of Common Stock
  issuable or reserved for issuance under the Plan were previously registered on the Registrant's Form S-8 (
  No. 333-226434
  ),
  which was filed with the Securities and Exchange Commission and declared effective on July 30, 2018, the contents of which are
  incorporated by reference herein. In accordance with the instructional note to Part I of Form S-8 as promulgated by the Commission,
  the information specified by Part I of Form S-8 has been omitted from this Registration Statement.
  PART II
  INFORMATION REQUIRED IN THE REGISTRATION
  STATEMENT
  Item 3.
  Incorporation of Documents by Reference.
  The following documents
  filed by the Registrant with the Commission pursuant to the Securities Act and the Securities Exchange Act of 1934, as amended
  (the "Exchange Act"), are incorporated herein by reference:
  (a)
  The Registrant's annual
      report on
  Form 10-K
  for the year ended December 31, 2019, as filed with the Commission on March 12, 2020, including
      information specifically incorporated into the Registrant's Form 10-K from the Registrant's definitive proxy statement
      on
  Schedule 14A
  , as filed with the Commission on April 29, 2020;
  (b)
  All other reports filed pursuant to Section 13(a) or 15(d) of the Exchange Act since the end of the fiscal year covered by the Registrant's Annual Report referred to in (a) above; and
  (c)
  The description of the Registrant's
      common stock contained in the Registrant's Registration Statement on
  Form 8-A
  filed with the SEC on December 13, 2017, including any amendments or reports filed for the purpose of updating such description.
  All
  documents subsequently filed by the Registrant pursuant to Sections 13(a), 13(c), 14 and 15(d) of the Exchange Act, prior to the
  filing of a post-effective amendment which indicates that all securities offered hereby have been sold or which deregisters all
  securities then remaining unsold, shall be deemed to be incorporated by reference herein and to be a part hereof from the date
  of the filing of such documents;
  provided
  ,
  however
  , that documents or information deemed to have been furnished
  and not filed in accordance with the rules of the Commission shall not be deemed incorporated by reference into this Registration
  Statement. Any statement contained in a document incorporated or deemed to be incorporated by reference herein shall be deemed
  to be modified or superseded for purposes of this Registration Statement to the extent that a statement contained in any subsequently
  filed document which also is deemed to be incorporated by reference herein modifies or supersedes such statement.
  2
  Item 8.
  Exhibits.
  The following exhibits are filed herewith:
  Exhibit
  Number
  Incorporated
          by Reference
  Filed
  Herewith
  Exhibit Description
  Form
  File No.
  Exhibit
  Filing Date
  3.1
  Third Amended and Restated Certificate of Incorporation of the Registrant.
  S-1
  333-200033
  3.2
  12/16/2014
  3.2
  Certificate of Amendment to Third Amended and Restated Certificate of Incorporation of the Registrant.
  8-K
  000-38326
  3.1
  06/18/2020
  3.2
  Amended and Restated Bylaws of the Registrant.
  S-1
  333-200033
  3.4
  12/16/2014
  5.1
  Opinion of Fenwick & West LLP.
  X
  23.1
  Consent of independent registered public accounting firm.
  X
  23.2
  Consent of Fenwick & West LLP (contained in Exhibit 5.1).
  X
  24.1
  Power of Attorney (included on the signature page to this Registration Statement).
  X
  99.1
  Amended and Restated 2011 Equity Incentive Plan.
  8-K
  000-55334
  10.1
  01/08/2015
  99.2
  Form of Option Agreement.
  S-1
  333-200033
  10.2
  11/07/2014
  99.3
  First Amendment to Amended and Restated 2011 Equity Incentive Plan.
  10-Q
  000-55334
  10.1
  08/14/2017
  99.4
  Second Amendment to Amended and Restated 2011 Equity Incentive Plan.
  S-8
  333-226434
  99.4
  07/30/2018
  99.5
  Third Amendment to Amended and Restated 2011 Equity Incentive Plan.
  X
  3
  SIGNATURES
  Pursuant to the requirements
  of the Securities Act, the Registrant certifies that it has reasonable grounds to believe that it meets all of the requirements
  for filing on Form S-8 and has duly caused this Registration Statement to be signed on its behalf by the undersigned, thereunto
  duly authorized, in the City of Menlo Park, State of California, on this 23rd day of June, 2020.
  COHBAR, INC.
  By:
  /s/ Jeffrey Biunno
  Jeffrey Biunno
  Principal Financial Officer
  4
  POWER OF ATTORNEY
  KNOW ALL PERSONS BY
  THESE PRESENTS
  , that each person whose signature appears below hereby constitutes and appoints Steven Engle and Jeffrey F.
  Biunno, and each of them, as his true and lawful attorney-in-fact and agent with full power of substitution, for him in any and
  all capacities, to sign any and all amendments (including post-effective amendments) to this Registration Statement on Form S-8,
  and to file the same, with all exhibits thereto and other documents in connection therewith, with the Securities and Exchange Commission,
  granting unto said attorney-in-fact and agent full power and authority to do and perform each and every act and thing requisite
  and necessary to be done in connection therewith, as fully for all intents and purposes as he or she might or could do in person,
  hereby ratifying and confirming all that said attorney-in-fact and agent, or his or her substitute, may lawfully do or cause to
  be done by virtue hereof.
  Pursuant to the requirements
  of the Securities Act, this Registration Statement has been signed by the following persons in the capacities and on the date indicated.
  Name
  Title
  Date
  Principal Executive Officer:
  /s/ Steven Engle
  Principal Executive Officer, Director
  June 23, 2020
  Steven Engle
  Principal Financial Officer and
  Principal Accounting Officer:
  /s/ Jeffrey F. Biunno
  Principal Financial Officer, Principal Accounting Officer
  June 23, 2020
  Jeffrey F. Biunno
  /s/ Albion J. Fitzgerald
  Chairman of the Board of Directors
  June 23, 2020
  Albion J. Fitzgerald
  /s/ Jon Stern
  Director
  June 23, 2020
  Jon Stern
  /s/ Nir Barzilai
  Director
  June 23, 2020
  Nir Barzilai
  /s/ Pinchas Cohen
  Director
  June 23, 2020
  Pinchas Cohen
  /s/ Phyllis Gardner
  Director
  June 23, 2020
  Phyllis Gardner
  /s/ David Greenwood
  Director
  June 23, 2020
  David Greenwood
  /s/ Misha Petkevich
  Director
  June 23, 2020
  Misha Petkevich
  5