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  <P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">As filed with the U.S. Securities and Exchange
  Commission on January 10, 2025</P>
  
  
  
  <P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: right">Registration No. 333-&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</P>
  
  <P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: right"></P>
  
  <!-- Field: Rule-Page --><DIV STYLE="margin-top: 0pt; margin-bottom: 0pt; width: 100%"><DIV STYLE="font-size: 1pt; border-top: Black 2pt solid; border-bottom: Black 1pt solid">&nbsp;</DIV></DIV><!-- Field: /Rule-Page -->
  
  <P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center">&nbsp;</P>
  
  
  
  <P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center"><FONT STYLE="font-size: 10pt">UNITED
  STATES<BR>
  SECURITIES AND EXCHANGE COMMISSION<BR>
  <FONT STYLE="font-weight: normal">Washington, D.C. 20549</FONT></FONT><FONT STYLE="font-weight: normal"><BR>
  <BR>
  </FONT><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">FORM S-8</FONT></P>
  
  <P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center">&nbsp;</P>
  
  <P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt"><BR>
  </FONT><FONT STYLE="font-family: Times New Roman, Times, Serif"><BR>
  REGISTRATION STATEMENT UNDER THE SECURITIES ACT OF 1933<BR>
  <BR>
  <FONT STYLE="font-size: 12pt">OS THERAPIES INCORPORATED</FONT></FONT><BR>
  <FONT STYLE="font-weight: normal">(Exact name of registrant as specified in its charter)</FONT></P>
  
  <P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center"><FONT STYLE="font-weight: normal">&nbsp;</FONT></P>
  
  <TABLE CELLSPACING="0" CELLPADDING="0" STYLE="width: 100%; font: 10pt Times New Roman, Times, Serif; border-collapse: collapse">
    <TR STYLE="vertical-align: bottom">
      <TD STYLE="border-bottom: Black 1.5pt solid; padding-top: 0pt; padding-right: 0pt; padding-left: 0pt; width: 49%; text-indent: 0pt"><P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>Delaware</B></P></TD>
      <TD STYLE="width: 2%">&nbsp;</TD>
      <TD STYLE="border-bottom: Black 1.5pt solid; padding-top: 0pt; padding-right: 0pt; padding-left: 0pt; width: 49%; font-size: 10pt; text-align: center; text-indent: 0pt"><B>82-5118368</B></TD></TR>
    <TR STYLE="vertical-align: top">
      <TD STYLE="padding: 0pt; font-size: 10pt; text-align: center; text-indent: 0pt">(State or other jurisdiction of<BR>
  incorporation or organization)</TD>
      <TD>&nbsp;</TD>
      <TD STYLE="padding: 0pt; font-size: 10pt; text-align: center; text-indent: 0pt">(I.R.S. Employer<BR>
   Identification No.)</TD></TR>
    <TR STYLE="vertical-align: bottom">
      <TD STYLE="padding: 0pt; font-size: 10pt; text-align: center; text-indent: 0pt">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD STYLE="padding: 0pt; font-size: 10pt; text-align: center; text-indent: 0pt">&nbsp;</TD></TR>
    <TR STYLE="vertical-align: bottom">
      <TD STYLE="border-bottom: Black 1.5pt solid; padding-top: 0pt; padding-right: 0pt; padding-left: 0pt; text-indent: 0pt">
      <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>115 Pullman Crossing Road, Suite 103</B></P>
      <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>Grasonville, Maryland</B></P></TD>
      <TD STYLE="padding-bottom: 1.5pt">&nbsp;</TD>
      <TD STYLE="border-bottom: Black 1.5pt solid; padding-top: 0pt; padding-right: 0pt; padding-left: 0pt; font-size: 10pt; text-align: center; text-indent: 0pt"><B>21638</B></TD></TR>
    <TR STYLE="vertical-align: top">
      <TD STYLE="padding: 0pt; font-size: 10pt; text-align: center; text-indent: 0pt">(Address of Principal Executive Offices)</TD>
      <TD>&nbsp;</TD>
      <TD STYLE="padding: 0pt; font-size: 10pt; text-align: center; text-indent: 0pt">(Zip Code)</TD></TR>
    </TABLE>
  <P STYLE="text-align: center; font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center"><B>2023 Incentive Compensation Plan<BR>
  </B>(Full title of the plan)</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center"><B>Paul A.&nbsp;Romness, MPH<BR>
  President and Chief Executive Officer<BR>
  OS Therapies Incorporated<BR>
  115 Pullman Crossing Road, Suite #103<BR>
  Grasonville, Maryland 21638<BR>
  (410)&nbsp;297-7793<BR>
  </B>(Name,&nbsp;address,&nbsp;including&nbsp;zip&nbsp;code,&nbsp;and&nbsp;telephone&nbsp;number,&nbsp;including&nbsp;area&nbsp;code,&nbsp;of&nbsp;agent&nbsp;for&nbsp;service)</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center">________________________</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center"><I>Copies to:</I></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center"><B>Spencer G.&nbsp;Feldman, Esq.<BR>
  Olshan Frome Wolosky LLP<BR>
  1325 Avenue of the Americas, 15<SUP>th</SUP> Floor<BR>
  New&nbsp;York, New&nbsp;York 10019<BR>
  (212)&nbsp;451-2300</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-right: 0; margin-bottom: 0pt; text-align: left">Indicate by check mark whether the registrant
  is a large accelerated filer, an accelerated filer, a non-accelerated filer or a smaller reporting company. See the definitions of &ldquo;large
  accelerated filer,&rdquo; &ldquo;accelerated filer&rdquo; and &ldquo;smaller reporting company&rdquo; in Rule 12b-2 of the Exchange Act.</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>
  
  <TABLE CELLSPACING="0" CELLPADDING="0" STYLE="width: 100%; font: 10pt Times New Roman, Times, Serif; border-collapse: collapse">
    <TR STYLE="vertical-align: bottom">
      <TD STYLE="padding: 0pt; width: 23%; text-indent: 0pt">
      <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Large accelerated filer</P></TD>
      <TD STYLE="width: 29%">&nbsp;&#9744;</TD>
      <TD STYLE="padding: 0pt; width: 33%; font-size: 10pt; text-indent: 0pt">Accelerated filer&nbsp;</TD>
      <TD STYLE="width: 15%">&nbsp;&#9744;</TD></TR>
    <TR STYLE="vertical-align: bottom">
      <TD STYLE="padding: 0pt; font-size: 10pt; text-indent: 0pt">Non-accelerated filer </TD>
      <TD>&nbsp;&#9746;</TD>
      <TD STYLE="padding: 0pt; font-size: 10pt; text-indent: 0pt">Smaller reporting company</TD>
      <TD>&nbsp;&#9746;</TD></TR>
    <TR STYLE="vertical-align: bottom">
      <TD STYLE="padding: 0pt; font-size: 10pt; text-indent: 0pt">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD STYLE="padding: 0pt; font-size: 10pt; text-indent: 0pt">Emerging growth company</TD>
      <TD>&nbsp;&#9746;</TD></TR>
    </TABLE>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: left">If an emerging&nbsp;growth company, indicate by
  check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting
  standards provided pursuant to Section 7(a)(2)(B) of the Securities Act.&nbsp;<FONT STYLE="font-family: Times New Roman, Times, Serif">&#9744;</FONT></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>
  
  <!-- Field: Rule-Page --><DIV STYLE="margin-top: 0pt; margin-bottom: 0pt; width: 100%"><DIV STYLE="font-size: 1pt; border-top: Black 1pt solid; border-bottom: Black 2pt solid">&nbsp;</DIV></DIV><!-- Field: /Rule-Page -->
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"></P>
  
  <!-- Field: Page; Sequence: 1 -->
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  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>EXPLANATORY NOTE</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">OS Therapies Incorporated (the &ldquo;Registrant&rdquo;)
  adopted its 2023 Incentive Compensation Plan in April 2023. The maximum number of shares of common stock of the Registrant that are available
  for issuance under the 2023 Incentive Compensation Plan is 4,000,000 shares. This registration statement on Form S-8 is being filed with
  the Securities and Exchange Commission (the &ldquo;SEC&rdquo;) for the purpose of registering the maximum number of shares of the Registrant&rsquo;s
  common stock that may be issued under its 2023 Incentive Compensation Plan.</P>
  
  <P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; text-indent: 0in">&nbsp;</P>
  
  <P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; text-indent: 0in"></P>
  
  <!-- Field: Page; Sequence: 2 -->
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  <P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; text-indent: 0in">&nbsp;</P>
  
  <P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center">PART I. INFORMATION REQUIRED
  IN THE SECTION 10(a) PROSPECTUS</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">The information specified by Items 1 and 2 of Part
  I of Form S-8 is omitted from this filing in accordance with the provisions of Rule 428 of the Securities Act of 1933, as amended (the
  &ldquo;Securities Act&rdquo;), and the introductory Note to Part I of Form S-8.</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">The documents containing the information specified
  in Part I of Form S-8 will be sent or given to participating employees as specified by Rule 428(b) of the Securities Act. Such documents
  and the documents incorporated by reference herein pursuant to Item 3 of Part II hereof, taken together, constitute a prospectus that
  meets the requirements of Section 10(a) of the Securities Act.</P>
  
  <P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; text-indent: 0in">&nbsp;</P>
  
  <P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; text-indent: 0in"></P>
  
  <!-- Field: Page; Sequence: 3; Options: NewSection -->
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  <P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; text-indent: 0in">&nbsp;</P>
  
  <P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center">PART II. INFORMATION REQUIRED
  IN THE REGISTRATION STATEMENT</P>
  
  <P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0in">&nbsp;</P>
  
  <TABLE CELLPADDING="0" CELLSPACING="0" STYLE="width: 100%; font: bold 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
  <TD STYLE="width: 0%"></TD><TD STYLE="width: 0.5in">Item 3.</TD><TD>Incorporation of Documents by Reference.</TD></TR></TABLE>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">The Registrant is subject to the informational
  and reporting requirements of Sections 13(a), 14 and 15(d) of the Securities Exchange Act of 1934, as amended (the &ldquo;Exchange Act&rdquo;),
  and in accordance therewith files reports and other information with the SEC. The following documents, which are on file with the SEC,
  are incorporated in this Registration Statement by reference:</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 1in; text-indent: -0.5in">&nbsp;</P>
  
  <TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
  <TD STYLE="width: 0.5in"></TD><TD STYLE="width: 0.5in">(a)</TD><TD>The Registrant&rsquo;s Quarterly Reports on Form 10-Q for the fiscal quarter ended March 31, 2024, filed with the SEC on <A HREF="http://www.sec.gov/Archives/edgar/data/1795091/000121390024045141/ea0206418-10q_osthera.htm">May 20, 2024</A>,
  the fiscal quarter ended June 30, 2024, filed with the SEC on <A HREF="http://www.sec.gov/Archives/edgar/data/1795091/000121390024069063/ea0211372-10q_ostherap.htm">August 14, 2024</A>, and the fiscal quarter ended September 30, 2024, filed
  with the SEC on <A HREF="http://www.sec.gov/Archives/edgar/data/1795091/000121390024098760/ea0221219-10q_ostherap.htm">November 15, 2024</A>;</TD></TR></TABLE>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 1in; text-indent: -0.5in">&nbsp;</P>
  
  <TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
  <TD STYLE="width: 0.5in"></TD><TD STYLE="width: 0.5in">(b)</TD><TD>The Registrant&rsquo;s Current Reports on Form 8-K (only to the extent &ldquo;filed&rdquo; and not &ldquo;furnished&rdquo;) filed
  with the SEC on <A HREF="http://www.sec.gov/Archives/edgar/data/1795091/000121390024071832/ea0212101-8k_osthera.htm">August 22, 2024</A>, <A HREF="http://www.sec.gov/Archives/edgar/data/1795091/000121390024091235/ea0218797-8k_osthera.htm">October 28, 2024</A>, <A HREF="http://www.sec.gov/Archives/edgar/data/1795091/000121390024093567/ea0219546-8k_osthera.htm">November 1, 2024</A>, <A HREF="http://www.sec.gov/Archives/edgar/data/1795091/000121390024113561/ea0226258-8k_osthera.htm">December 30, 2024</A>, and <A HREF="http://www.sec.gov/Archives/edgar/data/1795091/000121390025000844/ea0226635-8k_osthera.htm">January 3, 2025</A>;</TD></TR></TABLE>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 1in; text-indent: -0.5in">&nbsp;</P>
  
  <TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
  <TD STYLE="width: 0.5in"></TD><TD STYLE="width: 0.5in">(c)</TD><TD>The description of the Registrant&rsquo;s common stock contained in the prospectus that forms a part of the Registrant&rsquo;s Registration
  Statement on&nbsp;<A HREF="http://www.sec.gov/Archives/edgar/data/1795091/000121390024048049/ea0205761-03.htm">Form S-1</A>&nbsp;(File No. 333-279839) initially filed with the SEC on May 30, 2024.</TD></TR></TABLE>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">All documents filed by the Company pursuant to
  Sections 13(a), 13(c), 14 or 15(d) of the Securities Exchange Act of 1934, as amended (other than documents or information deemed to have
  been &ldquo;furnished&rdquo; and not &ldquo;filed&rdquo;), after the date hereof and before the filing of a post-effective amendment that
  indicates that all securities offered hereby have been sold or that deregisters all securities then remaining unsold shall be deemed to
  be incorporated by reference herein and to be part hereof from the date of filing those documents.</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&nbsp;Any statement contained in any document incorporated
  or deemed to be incorporated by reference herein shall be deemed to be modified or superseded for purposes of this registration statement
  to the extent that a statement contained herein or in any subsequently filed document which is or is deemed to be incorporated by reference
  herein modifies or supersedes the statement. Any statement so modified or superseded shall not be deemed, except as so modified or superseded,
  to constitute a part of this registration statement.</P>
  
  <P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0in">&nbsp;</P>
  
  <P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0in"></P>
  
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  <P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0in">&nbsp;</P>
  
  <TABLE CELLPADDING="0" CELLSPACING="0" STYLE="width: 100%; font: bold 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
  <TD STYLE="width: 0%"></TD><TD STYLE="width: 0.5in">Item 4.</TD><TD>Description of Securities.</TD></TR></TABLE>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">Not applicable.</P>
  
  <P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0in">&nbsp;</P>
  
  <TABLE CELLPADDING="0" CELLSPACING="0" STYLE="width: 100%; font: bold 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
  <TD STYLE="width: 0%"></TD><TD STYLE="width: 0.5in">Item 5.</TD><TD>Interests of Named Experts and Counsel.</TD></TR></TABLE>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">Not applicable.</P>
  
  <P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0in">&nbsp;</P>
  
  <TABLE CELLPADDING="0" CELLSPACING="0" STYLE="width: 100%; font: bold 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
  <TD STYLE="width: 0%"></TD><TD STYLE="width: 0.5in">Item 6.</TD><TD>Indemnification of Directors and Officers.</TD></TR></TABLE>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">Section 145 of the Delaware General Corporation
  Law (the &ldquo;DGCL&rdquo;) authorizes a corporation to indemnify its directors and officers against liabilities arising out of actions,
  suits and proceedings to which they are made or threatened to be made a party by reason of the fact that they have served or are currently
  serving as a director or officer to a corporation. The indemnity may cover expenses (including attorneys&rsquo; fees) judgments, fines
  and amounts paid in settlement actually and reasonably incurred by the director or officer in connection with any such action, suit or
  proceeding. Section 145 permits corporations to pay expenses (including attorneys&rsquo; fees) incurred by directors and officers in advance
  of the final disposition of such action, suit or proceeding. In addition, Section 145 provides that a corporation has the power to purchase
  and maintain insurance on behalf of its directors and officers against any liability asserted against them and incurred by them in their
  capacity as a director or officer, or arising out of their status as such, whether or not the corporation would have the power to indemnify
  the director or officer against such liability under Section 145.</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">We have adopted provisions in our certificate of
  incorporation and bylaws that limit or eliminate the personal liability of our directors to the fullest extent permitted by the DGCL,
  as it now exists or may in the future be amended. Consequently, a director will not be personally liable to us or our stockholders for
  monetary damages or breach of fiduciary duty as a director, except for liability for:</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in; text-indent: -0.25in">&nbsp;</P>
  
  <TABLE CELLPADDING="0" CELLSPACING="0" STYLE="width: 100%; font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
  <TD STYLE="width: 0.5in"></TD><TD STYLE="width: 0.25in">&#9679;</TD><TD>any breach of the director&rsquo;s duty of loyalty to us or our stockholders;</TD></TR></TABLE>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in; text-indent: -0.25in">&nbsp;</P>
  
  <TABLE CELLPADDING="0" CELLSPACING="0" STYLE="width: 100%; font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
  <TD STYLE="width: 0.5in"></TD><TD STYLE="width: 0.25in">&#9679;</TD><TD>any act or omission not in good faith or that involves intentional misconduct or a knowing violation of law;</TD></TR></TABLE>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in; text-indent: -0.25in">&nbsp;</P>
  
  <TABLE CELLPADDING="0" CELLSPACING="0" STYLE="width: 100%; font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
  <TD STYLE="width: 0.5in"></TD><TD STYLE="width: 0.25in">&#9679;</TD><TD>any unlawful payments related to dividends or unlawful stock purchases, redemptions or other distributions; or</TD></TR></TABLE>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in; text-indent: -0.25in">&nbsp;</P>
  
  <TABLE CELLPADDING="0" CELLSPACING="0" STYLE="width: 100%; font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
  <TD STYLE="width: 0.5in"></TD><TD STYLE="width: 0.25in">&#9679;</TD><TD>any transaction from which the director derived an improper personal benefit.</TD></TR></TABLE>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">These limitations of liability do not alter director
  liability under the federal securities laws and do not affect the availability of equitable remedies such as an injunction or rescission.</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">In addition, our bylaws provide that:</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in; text-indent: -0.25in">&nbsp;</P>
  
  <TABLE CELLPADDING="0" CELLSPACING="0" STYLE="width: 100%; font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
  <TD STYLE="width: 0.5in"></TD><TD STYLE="width: 0.25in">&#9679;</TD><TD>we will indemnify our directors, officers and, in the discretion of our board of directors, certain employees to the fullest extent
  permitted by the DGCL, as it now exists or may in the future be amended; and</TD></TR></TABLE>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in; text-indent: -0.25in">&nbsp;</P>
  
  <TABLE CELLPADDING="0" CELLSPACING="0" STYLE="width: 100%; font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
  <TD STYLE="width: 0.5in"></TD><TD STYLE="width: 0.25in">&#9679;</TD><TD STYLE="text-align: justify">we will advance reasonable expenses, including attorneys&rsquo; fees, to our directors and, in the discretion
  of our board of directors, to our officers and certain employees, in connection with legal proceedings relating to their service for or
  on behalf of us, subject to limited exceptions</TD></TR></TABLE>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">We intend to enter into separate indemnification
  agreements with each of our directors and executive officers. These agreements provide that we will indemnify each of our directors, our
  executive officers and, at times, their affiliates to the fullest extent permitted by Delaware law. We will advance expenses, including
  attorneys&rsquo; fees (but excluding judgments, fines and settlement amounts), to each indemnified director, executive officer or affiliate
  in connection with any proceeding in which indemnification is available and we will indemnify our directors and officers for any action
  or proceeding arising out of that person&rsquo;s services as a director or officer brought on behalf of us or in furtherance of our rights.
  Additionally, certain of our directors or officers may have certain rights to indemnification, advancement of expenses or insurance provided
  by their affiliates or other third parties, which indemnification relates to and might apply to the same proceedings arising out of such
  director&rsquo;s or officer&rsquo;s services as a director referenced herein. Nonetheless, we will agree in the indemnification agreements
  that our obligations to those same directors or officers are primary and any obligation of such affiliates or other third parties to advance
  expenses or to provide indemnification for the expenses or liabilities incurred by those directors are secondary.</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in"></P>
  
  <!-- Field: Page; Sequence: 5; Value: 1 -->
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  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">We also maintain general liability insurance which
  covers certain liabilities of our directors and officers arising out of claims based on acts or omissions in their capacities as directors
  or officers, including liabilities under the Securities Act.</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">The underwriting agreement to be filed as an exhibit
  to this registration statement is expected to provide for indemnification of us and our directors and officers by the underwriters against
  certain liabilities under the Securities Act and the Exchange&nbsp;Act.</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: -4.5pt"><B>&nbsp;</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt; text-indent: 0pt"><B>Delaware Law</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">Section&nbsp;102 of the DGCL permits a corporation
  to eliminate the personal liability of directors of a corporation to the corporation or its stockholders for monetary damages for a breach
  of fiduciary duty as a director, except where the director breached his duty of loyalty, failed to act in good faith, engaged in intentional
  misconduct or knowingly violated a law, authorized the payment of a dividend or approved a stock repurchase in violation of Delaware corporate
  law or obtained an improper personal benefit.</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">Section&nbsp;145 of the DGCL provides that a corporation
  has the power to indemnify a director, officer, employee, or agent of the corporation, or a person serving at the request of the corporation
  for another corporation, partnership, joint venture, trust or other enterprise in related capacities against expenses, including attorneys&rsquo;
  fees, judgments, fines and amounts paid in settlement actually and reasonably incurred by the person in connection with an action, suit
  or proceeding to which he was or is a party or is threatened to be made a party to any threatened, ending or completed action, suit or
  proceeding by reason of such position, if such person acted in good faith and in a manner he reasonably believed to be in or not opposed
  to the best interests of the corporation, and, in any criminal action or proceeding, had no reasonable cause to believe his conduct was
  unlawful, except that, in the case of actions brought by or in the right of the corporation, no indemnification will be made with respect
  to any claim, issue or matter as to which such person will have been adjudged to be liable to the corporation unless and only to the extent
  that the Court of Chancery or other adjudicating court determines that, despite the adjudication of liability but in view of all of the
  circumstances of the case, such person is fairly and reasonably entitled to indemnity for such expenses which the Court of Chancery or
  such other court will deem proper.</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: -4.5pt"><B>&nbsp;</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: -4.5pt"><B>Third Amended and Restated Certificate of Incorporation</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">Our third amended and restated certificate of incorporation
  provides that we are authorized to provide indemnification and advancement of expenses to our directors, officers and certain other covered
  persons to the fullest extent permitted by the DGCL.&nbsp;Our certificate of incorporation limits the personal liability of directors
  for breach of fiduciary duty to the maximum extent permitted by the DGCL and provides that no director will have personal liability to
  us or to our stockholders for monetary damages for breach of fiduciary duty or other duty as a director. However, these provisions will
  not eliminate or limit the liability of any of our directors for:</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in; text-indent: -0.25in">&nbsp;</P>
  
  <TABLE CELLPADDING="0" CELLSPACING="0" STYLE="width: 100%; font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
  <TD STYLE="width: 0.5in"></TD><TD STYLE="width: 0.25in">&#9679;</TD><TD>for any breach of the director&rsquo;s duty of loyalty to us or our stockholders;</TD></TR></TABLE>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in; text-indent: -0.25in">&nbsp;</P>
  
  <TABLE CELLPADDING="0" CELLSPACING="0" STYLE="width: 100%; font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
  <TD STYLE="width: 0.5in"></TD><TD STYLE="width: 0.25in">&#9679;</TD><TD>for acts or omissions not in good faith or that involve intentional misconduct or a knowing violation of law;</TD></TR></TABLE>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in; text-indent: -0.25in">&nbsp;</P>
  
  <TABLE CELLPADDING="0" CELLSPACING="0" STYLE="width: 100%; font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
  <TD STYLE="width: 0.5in"></TD><TD STYLE="width: 0.25in">&#9679;</TD><TD>for voting for or assenting to unlawful payments of dividends, stock repurchases or other distributions; or</TD></TR></TABLE>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in; text-indent: -0.25in">&nbsp;</P>
  
  <TABLE CELLPADDING="0" CELLSPACING="0" STYLE="width: 100%; font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
  <TD STYLE="width: 0.5in"></TD><TD STYLE="width: 0.25in">&#9679;</TD><TD>for any transaction from which the director derived an improper personal benefit.</TD></TR></TABLE>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in"></P>
  
  <!-- Field: Page; Sequence: 6; Value: 1 -->
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      <DIV STYLE="break-before: page; margin-top: 6pt; margin-bottom: 12pt"><P STYLE="margin: 0pt"></P></DIV>
      <!-- Field: /Page -->
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">In addition, our third amended and restated certificate
  of incorporation provides that we will indemnify each person who was or is a party or threatened to be made a party to any threatened,
  pending or completed action, suit or proceeding, other than an action by or in the right of us, by reason of the fact that such person
  is or was a director or officer of the Company or is or was serving at the request of the Company as a director, officer, employee, general
  partner, agent or fiduciary of another corporation, partnership, joint venture, trust or other enterprise (all such persons being referred
  to as an &ldquo;Indemnitee&rdquo;), against all expenses, including attorneys&rsquo; fees, judgments, fines and amounts paid in settlement
  actually and reasonably incurred in connection with such action, suit or proceeding, if such Indemnitee acted in good faith and in a manner
  he or she reasonably believed to be in, or not opposed to, our best interests, and, with respect to any criminal action or proceeding,
  he or she had no reasonable cause to believe his or her conduct was unlawful.</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0in"><B>&nbsp;</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0in"><B>Indemnification Agreements</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">We intend to enter into separate indemnification
  agreements with each of our directors and executive officers. These indemnification agreements may require us, among other things, to
  indemnify our directors and officers for some expenses, including attorneys&rsquo; fees, judgments, fines and settlement amounts incurred
  by a director or officer in any action or proceeding arising out of his or her service as one of our directors or officers, or any of
  our subsidiaries or any other company or enterprise to which the person provides services at our request.</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">We intend to apply for a general liability insurance
  policy that covers certain liabilities of our directors and officers arising out of claims based on their acts or omissions committed
  in their capacities as directors or officers.</P>
  
  <P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0in">&nbsp;</P>
  
  <TABLE CELLPADDING="0" CELLSPACING="0" STYLE="width: 100%; font: bold 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
  <TD STYLE="width: 0%"></TD><TD STYLE="width: 0.5in">Item 7.</TD><TD>Exemption from Registration Claimed.</TD></TR></TABLE>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">Not applicable.</P>
  
  <P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0in">&nbsp;</P>
  
  <TABLE CELLPADDING="0" CELLSPACING="0" STYLE="font: bold 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; width: 100%"><TR STYLE="vertical-align: top; text-align: justify">
  <TD STYLE="width: 0%"></TD><TD STYLE="width: 0.5in; text-align: left">Item 8.</TD><TD STYLE="text-align: justify"> Exhibits.</TD>
  </TR></TABLE>
  
  
  
  <P STYLE="margin-top: 0; margin-bottom: 0">&nbsp;</P>
  
  <TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
    <TR STYLE="vertical-align: top">
      <TD STYLE="border-bottom: Black 1.5pt solid; text-align: left; padding-top: 0pt; padding-right: 0pt; padding-left: 0pt; width: 9%; text-indent: 0pt; vertical-align: bottom"><FONT STYLE="font-family: Times New Roman, Times, Serif"><B><U STYLE="text-decoration: none">Exhibit<BR>
   number</U></B></FONT></TD>
      <TD STYLE="padding: 0pt 0pt 1.5pt; text-align: left; width: 1%; text-indent: 0pt; vertical-align: bottom"><FONT STYLE="font-family: Times New Roman, Times, Serif"><B>&nbsp;</B></FONT></TD>
      <TD STYLE="border-bottom: Black 1.5pt solid; text-align: left; padding-top: 0pt; padding-right: 0pt; padding-left: 0pt; width: 90%; text-indent: 0pt; vertical-align: bottom"><FONT STYLE="font-family: Times New Roman, Times, Serif"><B><U STYLE="text-decoration: none">Description</U></B></FONT></TD></TR>
    <TR STYLE="vertical-align: top; background-color: rgb(204,238,255)">
      <TD STYLE="padding: 0pt; text-indent: 0pt"><FONT STYLE="font-family: Times New Roman, Times, Serif">3.1</FONT></TD>
      <TD STYLE="padding: 0pt; text-indent: 0pt">&nbsp;</TD>
      <TD STYLE="padding: 0pt; text-indent: 0pt"><A HREF="http://www.sec.gov/Archives/edgar/data/1795091/000121390024048049/ea020576103ex3-1_osthera.htm"><FONT STYLE="font-family: Times New Roman, Times, Serif">Third Amended and Restated Certificate of Incorporation of OS Therapies Incorporated.<SUP>(1)</SUP></FONT></A></TD></TR>
    <TR STYLE="vertical-align: top; background-color: White">
      <TD STYLE="padding: 0pt; text-indent: 0pt"><FONT STYLE="font-family: Times New Roman, Times, Serif">3.2</FONT></TD>
      <TD STYLE="padding: 0pt; text-indent: 0pt">&nbsp;</TD>
      <TD STYLE="padding: 0pt; text-indent: 0pt"><A HREF="https://www.sec.gov/Archives/edgar/data/1795091/000121390024050739/ea020576106ex3-2_ostherap.htm"><FONT STYLE="font-family: Times New Roman, Times, Serif">Certificate of Amendment to the Third Amended and Restated Certificate of Incorporation of OS Therapies Incorporated.<SUP>(2)</SUP></FONT></A></TD></TR>
    <TR STYLE="vertical-align: top; background-color: rgb(204,238,255)">
      <TD STYLE="padding: 0pt; text-indent: 0pt"><FONT STYLE="font-family: Times New Roman, Times, Serif">3.3</FONT></TD>
      <TD STYLE="padding: 0pt; text-indent: 0pt">&nbsp;</TD>
      <TD STYLE="padding: 0pt; text-indent: 0pt"><A HREF="http://www.sec.gov/Archives/edgar/data/1795091/000121390024048049/ea020576103ex3-3_osthera.htm"><FONT STYLE="font-family: Times New Roman, Times, Serif">Amended and Restated Bylaws of OS Therapies Incorporated.<SUP>(1)</SUP></FONT></A></TD></TR>
    <TR STYLE="vertical-align: top; background-color: White">
      <TD STYLE="padding: 0pt; text-indent: 0pt"><FONT STYLE="font-family: Times New Roman, Times, Serif">4.1</FONT></TD>
      <TD STYLE="padding: 0pt; text-indent: 0pt">&nbsp;</TD>
      <TD STYLE="padding: 0pt; text-indent: 0pt"><A HREF="https://www.sec.gov/Archives/edgar/data/1795091/000121390024048049/ea020576103ex10-11_osthera.htm"><FONT STYLE="font-family: Times New Roman, Times, Serif">2023 Incentive Compensation Plan.<SUP>(3)</SUP></FONT></A></TD></TR>
    <TR STYLE="vertical-align: top; background-color: rgb(204,238,255)">
      <TD STYLE="padding: 0pt; text-indent: 0pt"><FONT STYLE="font-family: Times New Roman, Times, Serif">5.1*</FONT></TD>
      <TD STYLE="padding: 0pt; text-indent: 0pt">&nbsp;</TD>
      <TD STYLE="padding: 0pt; text-indent: 0pt"><A HREF="ea022733401ex5-1_ostherap.htm"><FONT STYLE="font-family: Times New Roman, Times, Serif">Opinion of Olshan Frome Wolosky LLP, as to the legality of the common stock.</FONT></A></TD></TR>
    <TR STYLE="vertical-align: top; background-color: White">
      <TD STYLE="padding: 0pt; text-indent: 0pt"><FONT STYLE="font-family: Times New Roman, Times, Serif">23.1*</FONT></TD>
      <TD STYLE="padding: 0pt; text-indent: 0pt">&nbsp;</TD>
      <TD STYLE="padding: 0pt; text-indent: 0pt"><A HREF="ea022733401ex23-1_ostherap.htm"><FONT STYLE="font-family: Times New Roman, Times, Serif">Consent of MaloneBailey, LLP, independent registered public accounting firm.</FONT></A></TD></TR>
    <TR STYLE="vertical-align: top; background-color: rgb(204,238,255)">
      <TD STYLE="padding: 0pt; text-indent: 0pt"><FONT STYLE="font-family: Times New Roman, Times, Serif">23.2*</FONT></TD>
      <TD STYLE="padding: 0pt; text-indent: 0pt">&nbsp;</TD>
      <TD STYLE="padding: 0pt; text-indent: 0pt"><A HREF="ea022733401ex5-1_ostherap.htm"><FONT STYLE="font-family: Times New Roman, Times, Serif">Consent of Olshan Frome Wolosky LLP (included in the opinion filed as Exhibit 5.1).</FONT></A></TD></TR>
    <TR STYLE="vertical-align: top; background-color: White">
      <TD STYLE="padding: 0pt; text-indent: 0pt"><FONT STYLE="font-family: Times New Roman, Times, Serif">24</FONT></TD>
      <TD STYLE="padding: 0pt; text-indent: 0pt">&nbsp;</TD>
      <TD STYLE="padding: 0pt; text-indent: 0pt"><A HREF="#a_001"><FONT STYLE="font-family: Times New Roman, Times, Serif">Power of Attorney (set forth on signature page of the Registration Statement).</FONT></A></TD></TR>
    <TR STYLE="vertical-align: top; background-color: rgb(204,238,255)">
      <TD STYLE="padding: 0pt; text-indent: 0pt"><FONT STYLE="font-family: Times New Roman, Times, Serif">107</FONT></TD>
      <TD STYLE="padding: 0pt; text-indent: 0pt">&nbsp;</TD>
      <TD STYLE="padding: 0pt; text-indent: 0pt"><A HREF="ea022733401ex-fee_ostherap.htm"><FONT STYLE="font-family: Times New Roman, Times, Serif">Calculation of Filing Fee Table.</FONT></A></TD></TR>
    </TABLE>
  
  <P STYLE="margin-top: 0; margin-bottom: 0">&nbsp;</P>
  
  <!-- Field: Rule-Page --><DIV STYLE="margin-top: 0pt; margin-bottom: 0pt; width: 25%"><DIV STYLE="font-size: 1pt; border-top: Black 1.5pt solid">&nbsp;</DIV></DIV><!-- Field: /Rule-Page -->
  
  <P STYLE="margin-top: 0; margin-bottom: 0"></P>
  
  <TABLE CELLPADDING="0" CELLSPACING="0" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; width: 100%"><TR STYLE="vertical-align: top; text-align: justify">
  <TD STYLE="width: 0.25in; text-align: left">(1)</TD><TD STYLE="text-align: left">Incorporated herein by reference to the Registrant&rsquo;s
  Registration Statement on Form&nbsp;S-1 filed May&nbsp;30, 2024 (File No.&nbsp;333-279839).</TD>
  </TR>
  <TR STYLE="vertical-align: top; text-align: justify">
  <TD STYLE="text-align: left">(2)</TD><TD STYLE="text-align: left">Incorporated herein by reference to Amendment No. 1 to the
  Registrant&rsquo;s Registration Statement on Form&nbsp;S-1 filed June&nbsp;7, 2024 (File No.&nbsp;333-279839).</TD>
  </TR>
  <TR STYLE="vertical-align: top; text-align: justify">
  <TD STYLE="text-align: left">(3)</TD><TD STYLE="text-align: left">Incorporated herein by reference to Amendment No. 2 to the
  Registrant&rsquo;s Registration Statement on Form&nbsp;S-1 filed June&nbsp;13, 2024 (File No.&nbsp;333-279839).</TD>
  </TR>
  <TR STYLE="vertical-align: top; text-align: justify">
  <TD STYLE="text-align: left">*</TD><TD STYLE="text-align: justify">Filed herewith.</TD>
  </TR></TABLE>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 24pt; text-align: justify; text-indent: -24pt">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 24pt; text-align: justify; text-indent: -24pt">Unless otherwise
  indicated, exhibit has been previously filed.</P>
  
  <P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0in">&nbsp;</P>
  
  <P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0in"></P>
  
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  <P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0in">&nbsp;</P>
  
  <TABLE CELLPADDING="0" CELLSPACING="0" STYLE="font: bold 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; width: 100%"><TR STYLE="vertical-align: top">
  <TD STYLE="width: 0%"></TD><TD STYLE="width: 0.5in">Item 9.</TD><TD>Undertakings.</TD></TR></TABLE>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0in">&nbsp;</P>
  
  <TABLE CELLPADDING="0" CELLSPACING="0" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; width: 100%"><TR STYLE="vertical-align: top; text-align: justify">
  <TD STYLE="width: 0.5in; text-align: left">(a)</TD><TD STYLE="text-align: justify">The undersigned Registrant hereby undertakes:</TD>
  </TR></TABLE>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&nbsp;</P>
  
  <P STYLE="text-align: left; font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">(1) To file, during any
  period in which offers or sales are being made, a post&minus;effective amendment to this registration statement:</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 81pt; text-indent: -27pt">&nbsp;</P>
  
  <TABLE CELLPADDING="0" CELLSPACING="0" STYLE="width: 100%; font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
  <TD STYLE="width: 0.75in"></TD><TD STYLE="width: 0.5in">(i)</TD><TD>To include any prospectus required by Section 10(a)(3) of the Securities Act;</TD></TR></TABLE>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 81pt; text-indent: -27pt">&nbsp;</P>
  
  <TABLE CELLPADDING="0" CELLSPACING="0" STYLE="width: 100%; font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
  <TD STYLE="width: 0.75in"></TD><TD STYLE="width: 0.5in">(ii)</TD><TD>To reflect in the prospectus any facts or events arising after the effective date of the registration statement (or the most recent
  post-effective amendment thereof) which, individually or in the aggregate, represent a fundamental change in the information set forth
  in the registration statement. Notwithstanding the foregoing, any increase or decrease in volume of securities offered (if the total dollar
  value of securities offered would not exceed that which was registered) and any deviation from the low or high end of the estimated maximum
  offering range may be reflected in the form of prospectus filed with the SEC pursuant to Rule 424(b) if, in the aggregate, the changes
  in volume and price represent no more than 20% change in the maximum aggregate offering price set forth in the &ldquo;Calculation of Filing
  Fee Tables&rdquo; or &ldquo;Calculation of Registration Fee&rdquo; table, as applicable, in the effective registration statement; and</TD></TR></TABLE>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 81pt; text-indent: -27pt">&nbsp;</P>
  
  <TABLE CELLPADDING="0" CELLSPACING="0" STYLE="width: 100%; font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
  <TD STYLE="width: 0.75in"></TD><TD STYLE="width: 0.5in">(iii)</TD><TD>To include any material information with respect to the plan of distribution not previously disclosed in the registration statement
  or any material change to such information in the registration statement;</TD></TR></TABLE>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in"><I>&nbsp;</I></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in"><I>provided, however</I>, that paragraphs (a)(1)(i)
  and (a)(1)(ii) do not apply if the information required to be included in a post-effective amendment by those paragraphs is contained
  in reports filed with or furnished to the SEC by the registrant pursuant to Section 13 or Section 15(d) of the Exchange Act that are incorporated
  by reference in this registration statement.</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">(2) That, for the purpose of determining any liability
  under the Securities Act, each such post-effective amendment shall be deemed to be a new registration statement relating to the securities
  offered therein, and the offering of such securities at that time shall be deemed to be the initial <I>bona fide</I> offering thereof.</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">(3) To remove from registration by means of a post-effective
  amendment any of the securities being registered which remain unsold at the termination of the offering.</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0in">&nbsp;</P>
  
  <TABLE CELLPADDING="0" CELLSPACING="0" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; width: 100%"><TR STYLE="vertical-align: top; text-align: justify">
  <TD STYLE="width: 0.5in; text-align: left">(b)</TD><TD STYLE="text-align: left">The undersigned registrant hereby undertakes that for the
  purpose of determining any liability under the Act, each filing of the registrant&rsquo;s annual report pursuant to Section 13(a) or
  15(d) of the Securities Exchange Act of 1934 (and, where applicable, each filing of an employee benefit plan&rsquo;s annual report pursuant
  to Section 15(d) of the Securities Exchange Act of 1934) that is incorporated by reference in the registration statement shall be deemed
  to be a new registration statement relating to the securities offered therein, and the offering of such securities at that time shall
  be deemed to be the initial bona fide offering thereof.</TD>
  </TR></TABLE>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0in">&nbsp;</P>
  
  <TABLE CELLPADDING="0" CELLSPACING="0" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; width: 100%"><TR STYLE="vertical-align: top; text-align: justify">
  <TD STYLE="width: 0.5in; text-align: left">(c)</TD><TD STYLE="text-align: left">Insofar as indemnification for liabilities arising under
  the Act may be permitted to directors, officers and controlling persons of the registrant pursuant to the foregoing provisions or otherwise,
  the registrant has been advised that in the opinion of the SEC such indemnification is against public policy as expressed in the Act
  and is therefore unenforceable. In the event that a claim for indemnification against such liabilities (other than the payment by the
  registrant of expenses incurred or paid by a director, officer or controlling person of the registrant in the successful defense of any
  action, suit or proceeding) is asserted by such director, officer or controlling person in connection with the securities being registered,
  the registrant will, unless in the opinion of its counsel the matter has been settled by controlling precedent, submit to a court of
  appropriate jurisdiction the question whether such indemnification by it is against public policy as expressed in the Act, and will be
  governed by the final adjudication of such issue.</TD>
  </TR></TABLE>
  
  <P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>
  
  
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  <P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>
  
  <P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">SIGNATURES</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">Pursuant to the requirements of the Securities
  Act of 1933, the registrant certifies that it has reasonable grounds to believe that it meets all of the requirements for filing on Form
  S-8 and has duly caused this registration statement to be signed on its behalf by the undersigned, thereunto duly authorized, in the City
  of Rockville, Maryland, on this 10<SUP>th</SUP> day of January, 2025.</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&nbsp;</P>
  
  <TABLE CELLSPACING="0" CELLPADDING="0" STYLE="width: 100%; font: 10pt Times New Roman, Times, Serif; border-collapse: collapse">
    <TR STYLE="vertical-align: top">
      <TD STYLE="padding: 0pt; text-indent: 0pt">
      <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P></TD>
      <TD COLSPAN="2" STYLE="padding: 0pt; text-indent: 0pt"><B>OS THERAPIES INCORPORATED</B></TD></TR>
    <TR STYLE="vertical-align: top">
      <TD STYLE="padding: 0pt; text-indent: 0pt">&nbsp;</TD>
      <TD COLSPAN="2" STYLE="padding: 0pt; text-indent: 0pt">&nbsp;</TD></TR>
    <TR STYLE="vertical-align: top">
      <TD STYLE="padding: 0pt; width: 60%; text-indent: 0pt">&nbsp;</TD>
      <TD STYLE="padding: 0pt; width: 4%; text-indent: 0pt">By:</TD>
      <TD STYLE="padding: 0pt; width: 36%; text-indent: 0pt">
      <P STYLE="border-bottom: Black 1.5pt solid; font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">/s/ Paul A. Romness, MPH</P></TD></TR>
    <TR STYLE="vertical-align: top">
      <TD STYLE="padding: 0pt; text-indent: 0pt">&nbsp;</TD>
      <TD STYLE="padding: 0pt; text-indent: 0pt">&nbsp;</TD>
      <TD STYLE="padding: 0pt; text-indent: 0pt">Paul A. Romness, MPH</TD></TR>
    <TR STYLE="vertical-align: top">
      <TD STYLE="padding: 0pt; text-indent: 0pt">&nbsp;</TD>
      <TD STYLE="padding: 0pt; text-indent: 0pt">&nbsp;</TD>
      <TD STYLE="padding: 0pt; text-indent: 0pt">President and Chief Executive Officer</TD></TR>
    </TABLE>
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B><A NAME="a_001"></A>POWER OF ATTORNEY</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">We, the undersigned officers and directors of OS
  Therapies Incorporated hereby severally constitute and appoint Paul A. Romness, MPH and Christopher P. Acevedo, and each of them, as his
  or her true and lawful attorney-in-fact and agent with full power of substitution, for him or her in any and all capacities, to sign any
  and all amendments to this registration statement on Form S-8 (including post-effective amendments), and to file the same, with all exhibits
  thereto and other documents in connection therewith, with the Securities and Exchange Commission, granting unto said attorney-in-fact,
  proxy and agent full power and authority to do and perform each and every act and thing requisite and necessary to be done in connection
  therewith, as fully for all intents and purposes as he or she might or could do in person, hereby ratifying and confirming all that said
  attorney-in-fact, proxy and agent, or his substitute, may lawfully do or cause to be done by virtue hereof.</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">Pursuant to the requirements of the Securities
  Act of 1933, this Registration Statement has been signed by the following persons in the capacities and on the date indicated.</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&nbsp;</P>
  
  <TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
    <TR STYLE="vertical-align: bottom">
      <TD STYLE="border-bottom: Black 1.5pt solid; text-align: center; padding-top: 0pt; padding-right: 0pt; padding-left: 0pt; width: 32%"><B>Signature</B></TD>
      <TD STYLE="padding-bottom: 1.5pt; text-align: center; width: 1%">&nbsp;</TD>
      <TD STYLE="border-bottom: Black 1.5pt solid; text-align: center; padding-top: 0pt; padding-right: 0pt; padding-left: 0pt; width: 48%"><B>Title</B></TD>
      <TD STYLE="padding-bottom: 1.5pt; text-align: center; width: 1%">&nbsp;</TD>
      <TD STYLE="border-bottom: Black 1.5pt solid; text-align: center; padding-top: 0pt; padding-right: 0pt; padding-left: 0pt; width: 18%"><B>Date</B></TD></TR>
    <TR STYLE="vertical-align: bottom">
      <TD STYLE="padding: 0pt; text-indent: 0pt">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD STYLE="padding: 0pt; text-indent: 0pt">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD STYLE="text-align: center; padding: 0pt">&nbsp;</TD></TR>
    <TR STYLE="vertical-align: bottom">
      <TD STYLE="border-bottom: Black 1.5pt solid; padding: 0pt; text-indent: 0pt">/s/ Paul A. Romness, MPH</TD>
      <TD>&nbsp;</TD>
      <TD STYLE="padding: 0pt; text-indent: 0pt">Chairman, President and Chief Executive Officer</TD>
      <TD>&nbsp;</TD>
      <TD STYLE="text-align: center; padding: 0pt">&nbsp; January 10, 2025</TD></TR>
    <TR>
      <TD STYLE="padding: 0pt; vertical-align: top; text-indent: 0pt">Paul A. Romness, MPH</TD>
      <TD>&nbsp;</TD>
      <TD STYLE="padding: 0pt; vertical-align: bottom; text-indent: 0pt"> (principal executive officer)</TD>
      <TD>&nbsp;</TD>
      <TD STYLE="text-align: center; padding: 0pt; vertical-align: bottom">&nbsp;</TD></TR>
    <TR STYLE="vertical-align: bottom">
      <TD STYLE="padding: 0pt; text-indent: 0pt">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD STYLE="padding: 0pt; text-indent: 0pt">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD STYLE="text-align: center; padding: 0pt">&nbsp;</TD></TR>
    <TR STYLE="vertical-align: bottom">
      <TD STYLE="border-bottom: Black 1.5pt solid; padding: 0pt; text-indent: 0pt">/s/ Christopher P. Acevedo</TD>
      <TD>&nbsp;</TD>
      <TD STYLE="padding: 0pt; text-indent: 0pt">Chief Financial Officer</TD>
      <TD>&nbsp;</TD>
      <TD STYLE="text-align: center; padding: 0pt">&nbsp; January 10, 2025</TD></TR>
    <TR STYLE="vertical-align: bottom">
      <TD STYLE="padding: 0pt; text-indent: 0pt">Christopher P. Acevedo</TD>
      <TD>&nbsp;</TD>
      <TD STYLE="padding: 0pt; text-indent: 0pt"> (principal financial officer and principal accounting officer)</TD>
      <TD>&nbsp;</TD>
      <TD STYLE="text-align: center; padding: 0pt">&nbsp;</TD></TR>
    <TR STYLE="vertical-align: bottom">
      <TD STYLE="padding: 0pt; text-indent: 0pt">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD STYLE="padding: 0pt; text-indent: 0pt">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD STYLE="text-align: center; padding: 0pt">&nbsp;</TD></TR>
    <TR STYLE="vertical-align: bottom">
      <TD STYLE="border-bottom: Black 1.5pt solid; padding: 0pt; text-indent: 0pt">/s/ John Ciccio</TD>
      <TD>&nbsp;</TD>
      <TD STYLE="padding: 0pt; text-indent: 0pt">Director</TD>
      <TD>&nbsp;</TD>
      <TD STYLE="text-align: center; padding: 0pt">&nbsp; January 10, 2025</TD></TR>
    <TR STYLE="vertical-align: bottom">
      <TD STYLE="padding: 0pt; text-indent: 0pt">John Ciccio</TD>
      <TD>&nbsp;</TD>
      <TD STYLE="padding: 0pt; text-indent: 0pt">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD STYLE="text-align: center; padding: 0pt">&nbsp;</TD></TR>
    <TR STYLE="vertical-align: bottom">
      <TD STYLE="padding: 0pt; text-indent: 0pt">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD STYLE="padding: 0pt; text-indent: 0pt">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD STYLE="text-align: center; padding: 0pt">&nbsp;</TD></TR>
    <TR STYLE="vertical-align: bottom">
      <TD STYLE="border-bottom: Black 1.5pt solid; padding: 0pt; text-indent: 0pt">/s/ Avril McKean Dieser</TD>
      <TD>&nbsp;</TD>
      <TD STYLE="padding: 0pt; text-indent: 0pt">Director</TD>
      <TD>&nbsp;</TD>
      <TD STYLE="text-align: center; padding: 0pt">&nbsp; January 10, 2025</TD></TR>
    <TR STYLE="vertical-align: bottom">
      <TD STYLE="padding: 0pt; text-indent: 0pt">Avril McKean Dieser</TD>
      <TD>&nbsp;</TD>
      <TD STYLE="padding: 0pt; text-indent: 0pt">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD STYLE="text-align: center; padding: 0pt">&nbsp;</TD></TR>
    <TR STYLE="vertical-align: bottom">
      <TD STYLE="padding: 0pt; text-indent: 0pt">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD STYLE="padding: 0pt; text-indent: 0pt">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD STYLE="text-align: center; padding: 0pt">&nbsp;</TD></TR>
    <TR STYLE="vertical-align: bottom">
      <TD STYLE="border-bottom: Black 1.5pt solid; padding: 0pt; text-indent: 0pt">/s/ Olivier R. Jarry</TD>
      <TD>&nbsp;</TD>
      <TD STYLE="padding: 0pt; text-indent: 0pt">Director</TD>
      <TD>&nbsp;</TD>
      <TD STYLE="text-align: center; padding: 0pt">&nbsp; January 10, 2025</TD></TR>
    <TR STYLE="vertical-align: bottom">
      <TD STYLE="padding: 0pt; text-indent: 0pt">Olivier R. Jarry</TD>
      <TD>&nbsp;</TD>
      <TD STYLE="padding: 0pt; text-indent: 0pt">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD STYLE="text-align: center; padding: 0pt">&nbsp;</TD></TR>
    <TR STYLE="vertical-align: bottom">
      <TD STYLE="padding: 0pt; text-indent: 0pt">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD STYLE="padding: 0pt; text-indent: 0pt">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD STYLE="text-align: center; padding: 0pt">&nbsp;</TD></TR>
    <TR STYLE="vertical-align: bottom">
      <TD STYLE="border-bottom: Black 1.5pt solid; padding: 0pt; text-indent: 0pt">/s/ Theodore F. Search, Pharm.D.</TD>
      <TD>&nbsp;</TD>
      <TD STYLE="padding: 0pt; text-indent: 0pt">Director</TD>
      <TD>&nbsp;</TD>
      <TD STYLE="text-align: center; padding: 0pt">&nbsp; January 10, 2025</TD></TR>
    <TR STYLE="vertical-align: bottom">
      <TD STYLE="padding: 0pt; text-indent: 0pt">Theodore F. Search, Pharm.D.</TD>
      <TD>&nbsp;</TD>
      <TD STYLE="padding: 0pt; text-indent: 0pt">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD STYLE="text-align: center; padding: 0pt">&nbsp;</TD></TR>
    </TABLE>
  
  <P STYLE="margin-top: 0; margin-bottom: 0">&nbsp;</P>
  
  
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metadata_filer: {"company-data": {"conformed-name": "OS Therapies Inc", "cik": "0001795091", "assigned-sic": "2834", "organization-name": "03 Life Sciences", "irs-number": "825118368", "state-of-incorporation": "DE", "fiscal-year-end": "1231"}, "filing-values": {"form-type": "S-8", "act": "33", "file-number": "333-284242", "film-number": "25525107"}, "business-address": {"street1": "15825 SHADY GROVE ROAD", "street2": "SUITE 135", "city": "ROCKVILLE", "state": "MD", "zip": "20850", "phone": "410-297-7793"}, "mail-address": {"street1": "15825 SHADY GROVE ROAD", "street2": "SUITE 135", "city": "ROCKVILLE", "state": "MD", "zip": "20850"}, "former-company": {"former-conformed-name": "OS THERAPIES Inc", "date-changed": "20191125"}}
text: As filed with the U.S. Securities and Exchange
  Commission on January 10, 2025
  Registration No. 333-
  UNITED
  STATES
  SECURITIES AND EXCHANGE COMMISSION
  Washington, D.C. 20549
  FORM S-8
  REGISTRATION STATEMENT UNDER THE SECURITIES ACT OF 1933
  OS THERAPIES INCORPORATED
  (Exact name of registrant as specified in its charter)
  Delaware
  82-5118368
  (State or other jurisdiction of
  incorporation or organization)
  (I.R.S. Employer
  Identification No.)
  115 Pullman Crossing Road, Suite 103
  Grasonville, Maryland
  21638
  (Address of Principal Executive Offices)
  (Zip Code)
  2023 Incentive Compensation Plan
  (Full title of the plan)
  Paul A. Romness, MPH
  President and Chief Executive Officer
  OS Therapies Incorporated
  115 Pullman Crossing Road, Suite #103
  Grasonville, Maryland 21638
  (410) 297-7793
  (Name, address, including zip code, and telephone number, including area code, of agent for service)
  ________________________
  Copies to:
  Spencer G. Feldman, Esq.
  Olshan Frome Wolosky LLP
  1325 Avenue of the Americas, 15
  th
  Floor
  New York, New York 10019
  (212) 451-2300
  Indicate by check mark whether the registrant
  is a large accelerated filer, an accelerated filer, a non-accelerated filer or a smaller reporting company. See the definitions of "large
  accelerated filer," "accelerated filer" and "smaller reporting company" in Rule 12b-2 of the Exchange Act.
  Large accelerated filer
  ☐
  Accelerated filer
  ☐
  Non-accelerated filer
  ☒
  Smaller reporting company
  ☒
  Emerging growth company
  ☒
  If an emerging growth company, indicate by
  check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting
  standards provided pursuant to Section 7(a)(2)(B) of the Securities Act.
  ☐
  EXPLANATORY NOTE
  OS Therapies Incorporated (the "Registrant")
  adopted its 2023 Incentive Compensation Plan in April 2023. The maximum number of shares of common stock of the Registrant that are available
  for issuance under the 2023 Incentive Compensation Plan is 4,000,000 shares. This registration statement on Form S-8 is being filed with
  the Securities and Exchange Commission (the "SEC") for the purpose of registering the maximum number of shares of the Registrant's
  common stock that may be issued under its 2023 Incentive Compensation Plan.
  PART I. INFORMATION REQUIRED
  IN THE SECTION 10(a) PROSPECTUS
  The information specified by Items 1 and 2 of Part
  I of Form S-8 is omitted from this filing in accordance with the provisions of Rule 428 of the Securities Act of 1933, as amended (the
  "Securities Act"), and the introductory Note to Part I of Form S-8.
  The documents containing the information specified
  in Part I of Form S-8 will be sent or given to participating employees as specified by Rule 428(b) of the Securities Act. Such documents
  and the documents incorporated by reference herein pursuant to Item 3 of Part II hereof, taken together, constitute a prospectus that
  meets the requirements of Section 10(a) of the Securities Act.
  1
  PART II. INFORMATION REQUIRED
  IN THE REGISTRATION STATEMENT
  Item 3.
  Incorporation of Documents by Reference.
  The Registrant is subject to the informational
  and reporting requirements of Sections 13(a), 14 and 15(d) of the Securities Exchange Act of 1934, as amended (the "Exchange Act"),
  and in accordance therewith files reports and other information with the SEC. The following documents, which are on file with the SEC,
  are incorporated in this Registration Statement by reference:
  (a)
  The Registrant's Quarterly Reports on Form 10-Q for the fiscal quarter ended March 31, 2024, filed with the SEC on
  May 20, 2024
  ,
  the fiscal quarter ended June 30, 2024, filed with the SEC on
  August 14, 2024
  , and the fiscal quarter ended September 30, 2024, filed
  with the SEC on
  November 15, 2024
  ;
  (b)
  The Registrant's Current Reports on Form 8-K (only to the extent "filed" and not "furnished") filed
  with the SEC on
  August 22, 2024
  ,
  October 28, 2024
  ,
  November 1, 2024
  ,
  December 30, 2024
  , and
  January 3, 2025
  ;
  (c)
  The description of the Registrant's common stock contained in the prospectus that forms a part of the Registrant's Registration
  Statement on
  Form S-1
  (File No. 333-279839) initially filed with the SEC on May 30, 2024.
  All documents filed by the Company pursuant to
  Sections 13(a), 13(c), 14 or 15(d) of the Securities Exchange Act of 1934, as amended (other than documents or information deemed to have
  been "furnished" and not "filed"), after the date hereof and before the filing of a post-effective amendment that
  indicates that all securities offered hereby have been sold or that deregisters all securities then remaining unsold shall be deemed to
  be incorporated by reference herein and to be part hereof from the date of filing those documents.
  Any statement contained in any document incorporated
  or deemed to be incorporated by reference herein shall be deemed to be modified or superseded for purposes of this registration statement
  to the extent that a statement contained herein or in any subsequently filed document which is or is deemed to be incorporated by reference
  herein modifies or supersedes the statement. Any statement so modified or superseded shall not be deemed, except as so modified or superseded,
  to constitute a part of this registration statement.
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  Item 4.
  Description of Securities.
  Not applicable.
  Item 5.
  Interests of Named Experts and Counsel.
  Not applicable.
  Item 6.
  Indemnification of Directors and Officers.
  Section 145 of the Delaware General Corporation
  Law (the "DGCL") authorizes a corporation to indemnify its directors and officers against liabilities arising out of actions,
  suits and proceedings to which they are made or threatened to be made a party by reason of the fact that they have served or are currently
  serving as a director or officer to a corporation. The indemnity may cover expenses (including attorneys' fees) judgments, fines
  and amounts paid in settlement actually and reasonably incurred by the director or officer in connection with any such action, suit or
  proceeding. Section 145 permits corporations to pay expenses (including attorneys' fees) incurred by directors and officers in advance
  of the final disposition of such action, suit or proceeding. In addition, Section 145 provides that a corporation has the power to purchase
  and maintain insurance on behalf of its directors and officers against any liability asserted against them and incurred by them in their
  capacity as a director or officer, or arising out of their status as such, whether or not the corporation would have the power to indemnify
  the director or officer against such liability under Section 145.
  We have adopted provisions in our certificate of
  incorporation and bylaws that limit or eliminate the personal liability of our directors to the fullest extent permitted by the DGCL,
  as it now exists or may in the future be amended. Consequently, a director will not be personally liable to us or our stockholders for
  monetary damages or breach of fiduciary duty as a director, except for liability for:
  ●
  any breach of the director's duty of loyalty to us or our stockholders;
  ●
  any act or omission not in good faith or that involves intentional misconduct or a knowing violation of law;
  ●
  any unlawful payments related to dividends or unlawful stock purchases, redemptions or other distributions; or
  ●
  any transaction from which the director derived an improper personal benefit.
  These limitations of liability do not alter director
  liability under the federal securities laws and do not affect the availability of equitable remedies such as an injunction or rescission.
  In addition, our bylaws provide that:
  ●
  we will indemnify our directors, officers and, in the discretion of our board of directors, certain employees to the fullest extent
  permitted by the DGCL, as it now exists or may in the future be amended; and
  ●
  we will advance reasonable expenses, including attorneys' fees, to our directors and, in the discretion
  of our board of directors, to our officers and certain employees, in connection with legal proceedings relating to their service for or
  on behalf of us, subject to limited exceptions
  We intend to enter into separate indemnification
  agreements with each of our directors and executive officers. These agreements provide that we will indemnify each of our directors, our
  executive officers and, at times, their affiliates to the fullest extent permitted by Delaware law. We will advance expenses, including
  attorneys' fees (but excluding judgments, fines and settlement amounts), to each indemnified director, executive officer or affiliate
  in connection with any proceeding in which indemnification is available and we will indemnify our directors and officers for any action
  or proceeding arising out of that person's services as a director or officer brought on behalf of us or in furtherance of our rights.
  Additionally, certain of our directors or officers may have certain rights to indemnification, advancement of expenses or insurance provided
  by their affiliates or other third parties, which indemnification relates to and might apply to the same proceedings arising out of such
  director's or officer's services as a director referenced herein. Nonetheless, we will agree in the indemnification agreements
  that our obligations to those same directors or officers are primary and any obligation of such affiliates or other third parties to advance
  expenses or to provide indemnification for the expenses or liabilities incurred by those directors are secondary.
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  We also maintain general liability insurance which
  covers certain liabilities of our directors and officers arising out of claims based on acts or omissions in their capacities as directors
  or officers, including liabilities under the Securities Act.
  The underwriting agreement to be filed as an exhibit
  to this registration statement is expected to provide for indemnification of us and our directors and officers by the underwriters against
  certain liabilities under the Securities Act and the Exchange Act.
  Delaware Law
  Section 102 of the DGCL permits a corporation
  to eliminate the personal liability of directors of a corporation to the corporation or its stockholders for monetary damages for a breach
  of fiduciary duty as a director, except where the director breached his duty of loyalty, failed to act in good faith, engaged in intentional
  misconduct or knowingly violated a law, authorized the payment of a dividend or approved a stock repurchase in violation of Delaware corporate
  law or obtained an improper personal benefit.
  Section 145 of the DGCL provides that a corporation
  has the power to indemnify a director, officer, employee, or agent of the corporation, or a person serving at the request of the corporation
  for another corporation, partnership, joint venture, trust or other enterprise in related capacities against expenses, including attorneys'
  fees, judgments, fines and amounts paid in settlement actually and reasonably incurred by the person in connection with an action, suit
  or proceeding to which he was or is a party or is threatened to be made a party to any threatened, ending or completed action, suit or
  proceeding by reason of such position, if such person acted in good faith and in a manner he reasonably believed to be in or not opposed
  to the best interests of the corporation, and, in any criminal action or proceeding, had no reasonable cause to believe his conduct was
  unlawful, except that, in the case of actions brought by or in the right of the corporation, no indemnification will be made with respect
  to any claim, issue or matter as to which such person will have been adjudged to be liable to the corporation unless and only to the extent
  that the Court of Chancery or other adjudicating court determines that, despite the adjudication of liability but in view of all of the
  circumstances of the case, such person is fairly and reasonably entitled to indemnity for such expenses which the Court of Chancery or
  such other court will deem proper.
  Third Amended and Restated Certificate of Incorporation
  Our third amended and restated certificate of incorporation
  provides that we are authorized to provide indemnification and advancement of expenses to our directors, officers and certain other covered
  persons to the fullest extent permitted by the DGCL. Our certificate of incorporation limits the personal liability of directors
  for breach of fiduciary duty to the maximum extent permitted by the DGCL and provides that no director will have personal liability to
  us or to our stockholders for monetary damages for breach of fiduciary duty or other duty as a director. However, these provisions will
  not eliminate or limit the liability of any of our directors for:
  ●
  for any breach of the director's duty of loyalty to us or our stockholders;
  ●
  for acts or omissions not in good faith or that involve intentional misconduct or a knowing violation of law;
  ●
  for voting for or assenting to unlawful payments of dividends, stock repurchases or other distributions; or
  ●
  for any transaction from which the director derived an improper personal benefit.
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  In addition, our third amended and restated certificate
  of incorporation provides that we will indemnify each person who was or is a party or threatened to be made a party to any threatened,
  pending or completed action, suit or proceeding, other than an action by or in the right of us, by reason of the fact that such person
  is or was a director or officer of the Company or is or was serving at the request of the Company as a director, officer, employee, general
  partner, agent or fiduciary of another corporation, partnership, joint venture, trust or other enterprise (all such persons being referred
  to as an "Indemnitee"), against all expenses, including attorneys' fees, judgments, fines and amounts paid in settlement
  actually and reasonably incurred in connection with such action, suit or proceeding, if such Indemnitee acted in good faith and in a manner
  he or she reasonably believed to be in, or not opposed to, our best interests, and, with respect to any criminal action or proceeding,
  he or she had no reasonable cause to believe his or her conduct was unlawful.
  Indemnification Agreements
  We intend to enter into separate indemnification
  agreements with each of our directors and executive officers. These indemnification agreements may require us, among other things, to
  indemnify our directors and officers for some expenses, including attorneys' fees, judgments, fines and settlement amounts incurred
  by a director or officer in any action or proceeding arising out of his or her service as one of our directors or officers, or any of
  our subsidiaries or any other company or enterprise to which the person provides services at our request.
  We intend to apply for a general liability insurance
  policy that covers certain liabilities of our directors and officers arising out of claims based on their acts or omissions committed
  in their capacities as directors or officers.
  Item 7.
  Exemption from Registration Claimed.
  Not applicable.
  Item 8.
  Exhibits.
  Exhibit
  number
  Description
  3.1
  Third Amended and Restated Certificate of Incorporation of OS Therapies Incorporated.
  (1)
  3.2
  Certificate of Amendment to the Third Amended and Restated Certificate of Incorporation of OS Therapies Incorporated.
  (2)
  3.3
  Amended and Restated Bylaws of OS Therapies Incorporated.
  (1)
  4.1
  2023 Incentive Compensation Plan.
  (3)
  5.1*
  Opinion of Olshan Frome Wolosky LLP, as to the legality of the common stock.
  23.1*
  Consent of MaloneBailey, LLP, independent registered public accounting firm.
  23.2*
  Consent of Olshan Frome Wolosky LLP (included in the opinion filed as Exhibit 5.1).
  24
  Power of Attorney (set forth on signature page of the Registration Statement).
  107
  Calculation of Filing Fee Table.
  (1)
  Incorporated herein by reference to the Registrant's
  Registration Statement on Form S-1 filed May 30, 2024 (File No. 333-279839).
  (2)
  Incorporated herein by reference to Amendment No. 1 to the
  Registrant's Registration Statement on Form S-1 filed June 7, 2024 (File No. 333-279839).
  (3)
  Incorporated herein by reference to Amendment No. 2 to the
  Registrant's Registration Statement on Form S-1 filed June 13, 2024 (File No. 333-279839).
  *
  Filed herewith.
  Unless otherwise
  indicated, exhibit has been previously filed.
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  Item 9.
  Undertakings.
  (a)
  The undersigned Registrant hereby undertakes:
  (1) To file, during any
  period in which offers or sales are being made, a post−effective amendment to this registration statement:
  (i)
  To include any prospectus required by Section 10(a)(3) of the Securities Act;
  (ii)
  To reflect in the prospectus any facts or events arising after the effective date of the registration statement (or the most recent
  post-effective amendment thereof) which, individually or in the aggregate, represent a fundamental change in the information set forth
  in the registration statement. Notwithstanding the foregoing, any increase or decrease in volume of securities offered (if the total dollar
  value of securities offered would not exceed that which was registered) and any deviation from the low or high end of the estimated maximum
  offering range may be reflected in the form of prospectus filed with the SEC pursuant to Rule 424(b) if, in the aggregate, the changes
  in volume and price represent no more than 20% change in the maximum aggregate offering price set forth in the "Calculation of Filing
  Fee Tables" or "Calculation of Registration Fee" table, as applicable, in the effective registration statement; and
  (iii)
  To include any material information with respect to the plan of distribution not previously disclosed in the registration statement
  or any material change to such information in the registration statement;
  provided, however
  , that paragraphs (a)(1)(i)
  and (a)(1)(ii) do not apply if the information required to be included in a post-effective amendment by those paragraphs is contained
  in reports filed with or furnished to the SEC by the registrant pursuant to Section 13 or Section 15(d) of the Exchange Act that are incorporated
  by reference in this registration statement.
  (2) That, for the purpose of determining any liability
  under the Securities Act, each such post-effective amendment shall be deemed to be a new registration statement relating to the securities
  offered therein, and the offering of such securities at that time shall be deemed to be the initial
  bona fide
  offering thereof.
  (3) To remove from registration by means of a post-effective
  amendment any of the securities being registered which remain unsold at the termination of the offering.
  (b)
  The undersigned registrant hereby undertakes that for the
  purpose of determining any liability under the Act, each filing of the registrant's annual report pursuant to Section 13(a) or
  15(d) of the Securities Exchange Act of 1934 (and, where applicable, each filing of an employee benefit plan's annual report pursuant
  to Section 15(d) of the Securities Exchange Act of 1934) that is incorporated by reference in the registration statement shall be deemed
  to be a new registration statement relating to the securities offered therein, and the offering of such securities at that time shall
  be deemed to be the initial bona fide offering thereof.
  (c)
  Insofar as indemnification for liabilities arising under
  the Act may be permitted to directors, officers and controlling persons of the registrant pursuant to the foregoing provisions or otherwise,
  the registrant has been advised that in the opinion of the SEC such indemnification is against public policy as expressed in the Act
  and is therefore unenforceable. In the event that a claim for indemnification against such liabilities (other than the payment by the
  registrant of expenses incurred or paid by a director, officer or controlling person of the registrant in the successful defense of any
  action, suit or proceeding) is asserted by such director, officer or controlling person in connection with the securities being registered,
  the registrant will, unless in the opinion of its counsel the matter has been settled by controlling precedent, submit to a court of
  appropriate jurisdiction the question whether such indemnification by it is against public policy as expressed in the Act, and will be
  governed by the final adjudication of such issue.
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  SIGNATURES
  Pursuant to the requirements of the Securities
  Act of 1933, the registrant certifies that it has reasonable grounds to believe that it meets all of the requirements for filing on Form
  S-8 and has duly caused this registration statement to be signed on its behalf by the undersigned, thereunto duly authorized, in the City
  of Rockville, Maryland, on this 10
  th
  day of January, 2025.
  OS THERAPIES INCORPORATED
  By:
  /s/ Paul A. Romness, MPH
  Paul A. Romness, MPH
  President and Chief Executive Officer
  POWER OF ATTORNEY
  We, the undersigned officers and directors of OS
  Therapies Incorporated hereby severally constitute and appoint Paul A. Romness, MPH and Christopher P. Acevedo, and each of them, as his
  or her true and lawful attorney-in-fact and agent with full power of substitution, for him or her in any and all capacities, to sign any
  and all amendments to this registration statement on Form S-8 (including post-effective amendments), and to file the same, with all exhibits
  thereto and other documents in connection therewith, with the Securities and Exchange Commission, granting unto said attorney-in-fact,
  proxy and agent full power and authority to do and perform each and every act and thing requisite and necessary to be done in connection
  therewith, as fully for all intents and purposes as he or she might or could do in person, hereby ratifying and confirming all that said
  attorney-in-fact, proxy and agent, or his substitute, may lawfully do or cause to be done by virtue hereof.
  Pursuant to the requirements of the Securities
  Act of 1933, this Registration Statement has been signed by the following persons in the capacities and on the date indicated.
  Signature
  Title
  Date
  /s/ Paul A. Romness, MPH
  Chairman, President and Chief Executive Officer
  January 10, 2025
  Paul A. Romness, MPH
  (principal executive officer)
  /s/ Christopher P. Acevedo
  Chief Financial Officer
  January 10, 2025
  Christopher P. Acevedo
  (principal financial officer and principal accounting officer)
  /s/ John Ciccio
  Director
  January 10, 2025
  John Ciccio
  /s/ Avril McKean Dieser
  Director
  January 10, 2025
  Avril McKean Dieser
  /s/ Olivier R. Jarry
  Director
  January 10, 2025
  Olivier R. Jarry
  /s/ Theodore F. Search, Pharm.D.
  Director
  January 10, 2025
  Theodore F. Search, Pharm.D.
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