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   <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Calibri" ALIGN="center"><B>As filed with the Securities and Exchange Commission on March&nbsp;13, 2025 </B></P>
  <P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:10pt; font-family:Calibri" ALIGN="right"><B>Registration <FONT STYLE="white-space:nowrap">No.&nbsp;333-&#8195;&#8195;&#8195;</FONT></B></P>
  <P STYLE="font-size:4pt;margin-top:0pt;margin-bottom:0pt">&nbsp;</P> <P STYLE="line-height:3.0pt;margin-top:0pt;margin-bottom:0pt;border-bottom:1px solid #000000">&nbsp;</P>
  <P STYLE="line-height:3.0pt;margin-top:0pt;margin-bottom:2pt;border-bottom:1px solid #000000">&nbsp;</P> <P STYLE="margin-top:4pt; margin-bottom:0pt; font-size:18pt; font-family:Calibri" ALIGN="center"><B>UNITED STATES </B></P>
  <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:18pt; font-family:Calibri" ALIGN="center"><B>SECURITIES AND EXCHANGE COMMISSION </B></P>
  <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:12pt; font-family:Calibri" ALIGN="center"><B>Washington, D.C. 20549 </B></P> <P STYLE="font-size:12pt;margin-top:0pt;margin-bottom:0pt">&nbsp;</P><center>
  <P STYLE="line-height:6.0pt;margin-top:0pt;margin-bottom:2pt;border-bottom:1.00pt solid #000000;width:21%">&nbsp;</P></center> <P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:18pt; font-family:Calibri" ALIGN="center"><B>FORM <FONT
  STYLE="white-space:nowrap">S-8</FONT> </B></P> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:18pt; font-family:Calibri" ALIGN="center"><B>REGISTRATION STATEMENT </B></P>
  <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:12pt; font-family:Calibri" ALIGN="center"><B><I>UNDER </I></B></P> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:12pt; font-family:Calibri" ALIGN="center"><B><I>THE SECURITIES ACT OF
  1933 </I></B></P> <P STYLE="font-size:12pt;margin-top:0pt;margin-bottom:0pt">&nbsp;</P><center> <P STYLE="line-height:6.0pt;margin-top:0pt;margin-bottom:2pt;border-bottom:1.00pt solid #000000;width:21%">&nbsp;</P></center>
  <P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:24pt; font-family:Calibri" ALIGN="center"><B>Enliven Therapeutics, Inc. </B></P> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Calibri" ALIGN="center"><B>(Exact name
  of registrant as specified in its charter) </B></P> <P STYLE="font-size:12pt;margin-top:0pt;margin-bottom:0pt">&nbsp;</P><center>
  <P STYLE="line-height:6.0pt;margin-top:0pt;margin-bottom:2pt;border-bottom:1.00pt solid #000000;width:21%">&nbsp;</P></center> <P STYLE="font-size:12pt;margin-top:0pt;margin-bottom:0pt">&nbsp;</P>
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  <TD VALIGN="top" ALIGN="center"><FONT STYLE="font-family:Calibri; "><B>Delaware</B></FONT></TD>
  <TD VALIGN="bottom">&nbsp;</TD>
  <TD VALIGN="top" ALIGN="center"><FONT STYLE="font-family:Calibri; "><B><FONT STYLE="white-space:nowrap">81-1523849</FONT></B></FONT></TD></TR>
  <TR STYLE="page-break-inside:avoid ; font-family:arial; font-size:8pt">
  <TD VALIGN="top" ALIGN="center"> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:8pt; font-family:Calibri" ALIGN="center"><B>(State or other jurisdiction of</B></P>
  <P STYLE="margin-top:0pt; margin-bottom:1pt; font-size:8pt; font-family:Calibri" ALIGN="center"><B>incorporation or organization)</B></P></TD>
  <TD VALIGN="bottom">&nbsp;</TD>
  <TD VALIGN="top" ALIGN="center"> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:8pt; font-family:Calibri" ALIGN="center"><B>(I.R.S. Employer</B></P>
  <P STYLE="margin-top:0pt; margin-bottom:1pt; font-size:8pt; font-family:Calibri" ALIGN="center"><B>Identification No.)</B></P></TD></TR>
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  <TD VALIGN="top" ALIGN="center"> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Calibri" ALIGN="center"><B>6200 Lookout Road</B></P>
  <P STYLE="margin-top:0pt; margin-bottom:1pt; font-size:10pt; font-family:Calibri" ALIGN="center"><B>Boulder, CO</B></P></TD>
  <TD VALIGN="bottom">&nbsp;</TD>
  <TD VALIGN="bottom" ALIGN="center"><FONT STYLE="font-family:Calibri; "><B>80301</B></FONT></TD></TR>
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  <TD VALIGN="top" ALIGN="center"><FONT STYLE="font-family:Calibri; "><B>(Address of Principal Executive Offices)</B></FONT></TD>
  <TD VALIGN="bottom">&nbsp;</TD>
  <TD VALIGN="top" ALIGN="center"><FONT STYLE="font-family:Calibri; "><B>(Zip Code)</B></FONT></TD></TR>
  </TABLE> <P STYLE="margin-top:24pt; margin-bottom:0pt; font-size:10pt; font-family:Calibri" ALIGN="center"><B>Enliven Therapeutics, Inc. Amended and Restated 2020 Equity Incentive Plan </B></P>
  <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:8pt; font-family:Calibri" ALIGN="center"><B>(Full title of the plan) </B></P> <P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:10pt; font-family:Calibri" ALIGN="center"><B>Samuel Kintz
  </B></P> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Calibri" ALIGN="center"><B>President and Chief Executive Officer </B></P>
  <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Calibri" ALIGN="center"><B>Enliven Therapeutics, Inc. </B></P> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Calibri" ALIGN="center"><B>6200 Lookout
  Road </B></P> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Calibri" ALIGN="center"><B>Boulder, CO 80301 </B></P> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:8pt; font-family:Calibri" ALIGN="center"><B>(Name and
  address of agent for service) </B></P> <P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:10pt; font-family:Calibri" ALIGN="center"><B>(720) <FONT STYLE="white-space:nowrap">647-8519</FONT> </B></P>
  <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:8pt; font-family:Calibri" ALIGN="center"><B>(Telephone number, including area code, of agent for service) </B></P> <P STYLE="font-size:12pt;margin-top:0pt;margin-bottom:0pt">&nbsp;</P><center>
  <P STYLE="line-height:6.0pt;margin-top:0pt;margin-bottom:2pt;border-bottom:1.00pt solid #000000;width:21%">&nbsp;</P></center> <P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:10pt; font-family:Calibri" ALIGN="center"><B><I>Copies to:
  </I></B></P> <P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:10pt; font-family:Calibri" ALIGN="center"><B>Tony Jeffries, Esq. </B></P>
  <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Calibri" ALIGN="center"><B>Jennifer Knapp, Esq. </B></P> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Calibri" ALIGN="center"><B>Wilson Sonsini
  Goodrich&nbsp;&amp; Rosati, </B></P> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Calibri" ALIGN="center"><B>Professional Corporation </B></P>
  <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Calibri" ALIGN="center"><B>1155 Canyon Blvd, Suite 400 </B></P> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Calibri" ALIGN="center"><B>Boulder, CO
  80302 </B></P> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Calibri" ALIGN="center"><B>(303) <FONT STYLE="white-space:nowrap">256-5900</FONT> </B></P>
  <P STYLE="font-size:12pt;margin-top:0pt;margin-bottom:0pt">&nbsp;</P><center> <P STYLE="line-height:6.0pt;margin-top:0pt;margin-bottom:2pt;border-bottom:1.00pt solid #000000;width:21%">&nbsp;</P></center>
  <P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:10pt; font-family:Calibri">Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, a <FONT STYLE="white-space:nowrap">non-accelerated</FONT> filer, a
  smaller reporting company or an emerging growth company. See the definitions of &#147;large accelerated filer,&#148; &#147;accelerated filer,&#148; &#147;smaller reporting company,&#148; and &#147;emerging growth company&#148; in Rule <FONT
  STYLE="white-space:nowrap">12b-2</FONT> of the Exchange Act. </P> <P STYLE="font-size:12pt;margin-top:0pt;margin-bottom:0pt">&nbsp;</P>
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  <TD VALIGN="bottom"><FONT STYLE="font-family:Calibri; ">Large&nbsp;accelerated&nbsp;filer</FONT></TD>
  <TD VALIGN="bottom">&nbsp;</TD>
  <TD VALIGN="bottom"><FONT STYLE="font-family:Calibri; "><FONT STYLE="font-family:Times New Roman">&#9744;</FONT></FONT></TD>
  <TD VALIGN="bottom">&nbsp;&nbsp;</TD>
  <TD VALIGN="bottom"><FONT STYLE="font-family:Calibri; ">Accelerated&nbsp;filer</FONT></TD>
  <TD VALIGN="bottom">&nbsp;</TD>
  <TD VALIGN="bottom"><FONT STYLE="font-family:Calibri; "><FONT STYLE="font-family:Times New Roman">&#9744;</FONT></FONT></TD></TR>
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  <TD VALIGN="bottom"><FONT STYLE="font-family:Calibri; "><FONT STYLE="white-space:nowrap">Non-accelerated</FONT> filer</FONT></TD>
  <TD VALIGN="bottom">&nbsp;</TD>
  <TD VALIGN="bottom"><FONT STYLE="font-family:Calibri; "><FONT STYLE="font-family:Times New Roman">&#9746;</FONT></FONT></TD>
  <TD VALIGN="bottom">&nbsp;&nbsp;</TD>
  <TD VALIGN="bottom"><FONT STYLE="font-family:Calibri; ">Smaller&nbsp;reporting&nbsp;company</FONT></TD>
  <TD VALIGN="bottom">&nbsp;</TD>
  <TD VALIGN="bottom"><FONT STYLE="font-family:Calibri; "><FONT STYLE="font-family:Times New Roman">&#9746;</FONT></FONT></TD></TR>
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  <TD VALIGN="bottom">&nbsp;</TD>
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  <TD VALIGN="bottom">&nbsp;&nbsp;</TD>
  <TD VALIGN="bottom"><FONT STYLE="font-family:Calibri; ">Emerging growth company</FONT></TD>
  <TD VALIGN="bottom">&nbsp;</TD>
  <TD VALIGN="bottom"><FONT STYLE="font-family:Calibri; "><FONT STYLE="font-family:Times New Roman">&#9746;</FONT></FONT></TD></TR>
  </TABLE> <P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:10pt; font-family:Calibri">If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for
  complying with any new or revised financial accounting standards provided pursuant to Section&nbsp;7(a)(2)(B) of the Securities Act.&#8194;<FONT STYLE="font-family:Times New Roman">&#9744;</FONT></P>
  <P STYLE="font-size:10pt;margin-top:0pt;margin-bottom:0pt">&nbsp;</P> <P STYLE="line-height:3.0pt;margin-top:0pt;margin-bottom:0pt;border-bottom:1px solid #000000">&nbsp;</P>
  <P STYLE="line-height:3.0pt;margin-top:0pt;margin-bottom:2pt;border-bottom:1px solid #000000">&nbsp;</P>
  </DIV></Center>
  
  
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   <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Calibri" ALIGN="center"><B>EXPLANATORY NOTE </B></P>
  <P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:10pt; font-family:Calibri">Enliven Therapeutics, Inc. (the &#147;<B>Registrant</B>&#148;) is filing this Registration Statement on Form <FONT STYLE="white-space:nowrap">S-8</FONT> (the
  &#147;<B>Registration Statement</B>&#148;) with the Securities and Exchange Commission (the &#147;<B>Commission</B>&#148;) to register 2,202,140 additional shares of Common Stock reserved for issuance under the Registrant&#146;s Amended and Restated
  2020 Equity Incentive Plan (the &#147;<B>2020 Plan</B>&#148;). </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:10pt; font-family:Calibri">The number of shares of Common Stock reserved and available for issuance under the 2020 Plan is
  subject to an automatic annual increase on the first day of each fiscal year during the term of the plan, beginning with the fiscal year commencing on January&nbsp;1, 2024, and continuing for each fiscal year until, and including, the fiscal year
  commencing on January&nbsp;1, 2032, equal to the least of (i) 4.5% of the number of shares of the Registrant&#146;s Common Stock outstanding on the first day of such fiscal year or (ii)&nbsp;an amount determined by the Registrant&#146;s board of
  directors; provided that, subject to certain capitalization adjustments, up to 7,175,000 shares of Common Stock may be granted as &#147;incentive stock options&#148; under the 2020 Plan. </P>
  <P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:10pt; font-family:Calibri">Accordingly, contents of (i)&nbsp;the previous registration statement on Form <FONT STYLE="white-space:nowrap">S-8</FONT> filed by the Registrant with the Commission
  on <A HREF="http://www.sec.gov/Archives/edgar/data/1672619/000119312520071587/d877539ds8.htm"><U>March</U><U></U><U>&nbsp;12, 2020</U></A> (File <FONT STYLE="white-space:nowrap">No.&nbsp;333-237117),</FONT> (ii) the previous registration statement
  on Form <FONT STYLE="white-space:nowrap">S-8</FONT> filed by the Registrant with the Commission on <A HREF="http://www.sec.gov/Archives/edgar/data/1672619/000156459021041915/imra-s8.htm"><U>August</U><U></U><U>&nbsp;6, 2021</U></A> (File <FONT
  STYLE="white-space:nowrap">No.&nbsp;
  333-258538),</FONT> (iii) the previous registration statement on Form <FONT STYLE="white-space:nowrap">S-8</FONT> filed by the Registrant with the Commission on <A HREF="http://www.sec.gov/Archives/edgar/data/1672619/000156459022010223/imra-s8.htm"><U>March
  </U><U></U><U>&nbsp;15, 2022</U></A> (File <FONT STYLE="white-space:nowrap">No.&nbsp;
  333-263554),</FONT> (iv) the previous registration statement on Form <FONT STYLE="white-space:nowrap">S-8</FONT> filed by the Registrant with the Commission on <A HREF="http://www.sec.gov/Archives/edgar/data/1672619/000119312523056480/d476001ds8.htm">
  <U>March</U><U></U><U>&nbsp;1, 2023</U></A> (File <FONT STYLE="white-space:nowrap">No.&nbsp;333-270188),</FONT> (v) the previous registration statement on Form <FONT STYLE="white-space:nowrap">S-8</FONT> filed by the Registrant with the Commission
  on <A HREF="http://www.sec.gov/Archives/edgar/data/1672619/000119312524068024/d797770ds8.htm">March<U></U>&nbsp;14, 2024</A> (File <FONT STYLE="white-space:nowrap">No.&nbsp;333-277949),</FONT> and (vi)&nbsp;the previous registration statement on
  Form <FONT STYLE="white-space:nowrap">S-8</FONT> filed by the Registrant with the Commission on <A HREF="http://www.sec.gov/Archives/edgar/data/1672619/000119312524163646/d850357ds8.htm">June<U></U>&nbsp;20, 2024</A> (File <FONT
  STYLE="white-space:nowrap">No.&nbsp;333-280322),</FONT> (together, the &#147;<B>Previous Forms <FONT STYLE="white-space:nowrap">S-8</FONT></B>&#148;), including the information incorporated by reference therein and the periodic reports filed after
  the Previous Forms <FONT STYLE="white-space:nowrap">S-8</FONT> to maintain current information about the Registrant, are incorporated by reference into this Registration Statement pursuant to General Instruction E of Form <FONT
  STYLE="white-space:nowrap">S-8.</FONT> </P>
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   <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Calibri" ALIGN="center"><B>PART I </B></P>
  <P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:10pt; font-family:Calibri" ALIGN="center"><B>INFORMATION REQUIRED IN THE SECTION 10(a) PROSPECTUS </B></P> <P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:10pt; font-family:Calibri">The
  information specified in Item 1 and Item 2 of Part I of Form <FONT STYLE="white-space:nowrap">S-8</FONT> is omitted from this Registration Statement in accordance with the provisions of Rule 428 under the Securities Act of 1933, as amended (the
  &#147;<B>Securities Act</B>&#148;) and the introductory note to Part I of Form <FONT STYLE="white-space:nowrap">S-8.</FONT> The documents containing the information specified in Part I of Form <FONT STYLE="white-space:nowrap">S-8</FONT> will be
  delivered to the participants in the equity benefit plans covered by this Registration Statement as specified by Rule 428(b)(1) under the Securities Act. These documents and the documents incorporated by reference in this Registration Statement
  pursuant to Item 3 of Part II of Form <FONT STYLE="white-space:nowrap">S-8,</FONT> taken together, constitute a prospectus that meets the requirements of Section&nbsp;10(a) of the Securities Act. </P>
  <P STYLE="margin-top:24pt; margin-bottom:0pt; font-size:10pt; font-family:Calibri" ALIGN="center"><B>PART II </B></P> <P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:10pt; font-family:Calibri" ALIGN="center"><B>INFORMATION REQUIRED IN THE
  REGISTRATION STATEMENT </B></P> <P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:10pt; font-family:Calibri"><B>Item&#8201;3. Incorporation of Documents by Reference. </B></P>
  <P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:10pt; font-family:Calibri">The Registrant hereby incorporates by reference into this Registration Statement the following documents previously filed with the Commission: </P>
  <P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:10pt; font-family:Calibri">(1) The Registrant&#146;s Annual Report on <U><A HREF="http://www.sec.gov/Archives/edgar/data/../../../ix?doc=/Archives/edgar/data/1672619/000095017025038758/elvn-20241231.htm">Form
   <FONT STYLE="white-space:nowrap">10-K</FONT></A></U> for the fiscal year ended December&nbsp;31, 2024, filed with the Commission on March&nbsp;13, 2025; </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:10pt; font-family:Calibri">(2) All
  other reports filed with the Commission pursuant to Section&nbsp;13(a) or 15(d) of the Securities Exchange Act of 1934, as amended (the &#147;<B>Exchange Act</B>&#148;), since the end of the fiscal year covered by the Registrant&#146;s Annual Report
  on Form <FONT STYLE="white-space:nowrap">10-K</FONT> referred to in (1)&nbsp;above; and </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:10pt; font-family:Calibri">(3) The description of the Registrant&#146;s Common Stock contained in
  the Registrant&#146;s registration statement on <A HREF="http://www.sec.gov/Archives/edgar/data/1672619/000119312520067117/d886378d8a12b.htm">Form <FONT STYLE="white-space:nowrap">8-A</FONT></A>, filed with the Commission on March&nbsp;9, 2020
  pursuant to Section&nbsp;
  12(b) of the Exchange Act, and as set forth by the description of the Registrant&#146;s Common Stock set forth in the Registrant&#146;s registration statement on <A HREF="http://www.sec.gov/Archives/edgar/data/1672619/000119312523003729/d401639ds4a.htm">Form
   S-4/A</A>, filed with the Commission on January&nbsp;
  9, 2023, and as set forth by the description of the Registrant&#146;s Common Stock set forth in <A HREF="http://www.sec.gov/Archives/edgar/data/1672619/000095017024031495/elvn-ex4_2.htm">Exhibit 4.2</A> of the Registrant&#146;s Annual Report on <A HREF="http://www.sec.gov/Archives/edgar/data/../../../ix?doc=/Archives/edgar/data/1672619/000095017024031495/elvn-20231231.htm">Form
   <FONT STYLE="white-space:nowrap">10-K</FONT></A> for the fiscal year ended December&nbsp;31, 2023, filed with the Commission on March&nbsp;14, 2024, including any amendment or report filed for the purpose of updating such description. </P>
  <P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:10pt; font-family:Calibri">All documents filed by the Registrant pursuant to Sections 13(a), 13(c), 14 and 15(d) of the Exchange Act on or after the date of this Registration Statement and
  prior to the filing of a post-effective amendment to this Registration Statement that indicates that all securities offered have been sold or that deregisters all securities then remaining unsold shall be deemed to be incorporated by reference in
  this Registration Statement and to be a part hereof from the date of filing of such documents; <I>provided</I>, <I>however</I>, that documents or information deemed to have been furnished and not filed in accordance with the rules of the Commission
  shall not be deemed incorporated by reference into this Registration Statement. Any statement contained in a document incorporated or deemed to be incorporated by reference herein shall be deemed to be modified or superseded for purposes of this
  Registration Statement to the extent that a statement contained herein or in any subsequently filed document which also is deemed to be incorporated by reference herein modifies or supersedes such statement. Any such statement so modified or
  superseded shall not be deemed, except as so modified or superseded, to constitute a part of this Registration Statement. </P>
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   <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Calibri"><B>Item&#8201;4. Description of Securities. </B></P>
  <P STYLE="margin-top:6pt; margin-bottom:0pt; font-size:10pt; font-family:Calibri">Not applicable. </P> <P STYLE="margin-top:18pt; margin-bottom:0pt; font-size:10pt; font-family:Calibri"><B>Item&#8201;5. Interests of Named Experts and Counsel.
  </B></P> <P STYLE="margin-top:6pt; margin-bottom:0pt; font-size:10pt; font-family:Calibri">The validity of the shares of Common Stock offered hereby will be passed upon for the Registrant by Wilson Sonsini Goodrich&nbsp;&amp; Rosati, Professional
  Corporation, Boulder, CO. Investment funds associated with Wilson Sonsini Goodrich&nbsp;&amp; Rosati, Professional Corporation, hold an aggregate of 31,070 shares of Common Stock, which represent less than 1% of the Registrant&#146;s outstanding
  shares of Common Stock. </P> <P STYLE="margin-top:18pt; margin-bottom:0pt; font-size:10pt; font-family:Calibri"><B>Item&#8201;6. Indemnification of Directors and Officers. </B></P>
  <P STYLE="margin-top:6pt; margin-bottom:0pt; font-size:10pt; font-family:Calibri">Subsection (a)&nbsp;of Section&nbsp;145 of the Delaware General Corporation Law (&#147;<B>DGCL</B>&#148;) empowers a corporation to indemnify any person who was or is
  a party or who is threatened to be made a party to any threatened, pending or completed action, suit or proceeding, whether civil, criminal, administrative or investigative (other than an action by or in the right of the corporation) by reason of
  the fact that the person is or was a director, officer, employee or agent of the corporation, or is or was serving at the request of the corporation as a director, officer, employee or agent of another corporation, partnership, joint venture, trust
  or other enterprise, against expenses (including attorneys&#146; fees), judgments, fines and amounts paid in settlement actually and reasonably incurred by the person in connection with such action, suit or proceeding if the person acted in good
  faith and in a manner the person reasonably believed to be in or not opposed to the best interests of the corporation, and, with respect to any criminal action or proceeding, had no reasonable cause to believe the person&#146;s conduct was unlawful.
  </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:10pt; font-family:Calibri">Subsection (b)&nbsp;of Section&nbsp;145 empowers a corporation to indemnify any person who was or is a party or is threatened to be made a party to any
  threatened, pending or completed action or suit by or in the right of the corporation to procure a judgment in its favor by reason of the fact that the person acted in any of the capacities set forth above, against expenses (including
  attorneys&#146; fees) actually and reasonably incurred by the person in connection with the defense or settlement of such action or suit if the person acted in good faith and in a manner the person reasonably believed to be in or not opposed to the
  best interests of the corporation, except that no indemnification shall be made in respect of any claim, issue or matter as to which such person shall have been adjudged to be liable to the corporation unless and only to the extent that the Delaware
  Court of Chancery or the court in which such action or suit was brought shall determine upon application that, despite the adjudication of liability but in view of all the circumstances of the case, such person is fairly and reasonably entitled to
  indemnity for such expenses which the Delaware Court of Chancery or such other court shall deem proper. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:10pt; font-family:Calibri">Section&nbsp;145 further provides that to the extent a
  present or former director or officer of a corporation has been successful on the merits or otherwise in the defense of any action, suit or proceeding referred to in subsections (a)&nbsp;and (b) of Section&nbsp;145, or in defense of any claim, issue
  or matter therein, such person shall be indemnified against expenses (including attorneys&#146; fees) actually and reasonably incurred by such person in connection therewith; that indemnification and advancement of expenses provided for by
  Section&nbsp;145 shall not be deemed exclusive of any other rights to which the indemnified party may be entitled; and the indemnification and advancement of expenses provided for by Section&nbsp;145 shall, unless otherwise provided when authorized
  or ratified, continue as to a person who has ceased to be a director, officer, employee or agent and shall inure to the benefit of such person&#146;s heirs, executors and administrators. Section&nbsp;145 also empowers the corporation to purchase and
  maintain insurance on behalf of any person who is or was a director, officer, employee or agent of the corporation, or is or was serving at the request of the corporation as a director, officer, employee or agent of another corporation, partnership,
  joint venture, trust or other enterprise against any liability asserted against such person and incurred by such person in any such capacity, or arising out of his status as such, whether or not the corporation would have the power to indemnify such
  person against such liabilities under Section&nbsp;145. </P>
  </DIV></Center>
  
  
  <p style="margin-top:1em; margin-bottom:0em; page-break-before:always"> </p>
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   <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Calibri">Section&nbsp;102(b)(7) of the DGCL provides that a corporation&#146;s certificate of incorporation may contain a
  provision eliminating or limiting the personal liability of a director or officer to the corporation or its stockholders for monetary damages for breach of fiduciary duty as a director or officer, with certain exceptions described below. </P>
  <P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:10pt; font-family:Calibri">The Registrant&#146;s restated certificate of incorporation contains provisions that eliminate, to the maximum extent permitted by the DGCL, the personal liability of
  directors and certain of its officers for monetary damages for breach of their fiduciary duties as a director or officer. The Registrant&#146;s restated certificate of incorporation provides that the Registrant shall indemnify its directors and
  officers and may indemnify its employees and other agents to the fullest extent permitted by the DGCL. However, the DGCL prohibits the Registrant from limiting the liability of directors for (i)&nbsp;any breach of a director&#146;s duty of loyalty
  to the Registrant or to the Registrant&#146;s stockholders, (ii)&nbsp;any act or omission not in good faith or that involves intentional misconduct or a knowing violation of law, (iii)&nbsp;unlawful payment of dividends or unlawful stock repurchases
  or redemptions as provided in Section&nbsp;174 of the DGCL, or (iv)&nbsp;any transaction from which a director derived an improper personal benefit. Similarly, officers who at the time of an act or omission as to which liability is asserted
  consented to or are deemed to have consented to certain service of process rules under Delaware law will not be personally liable to the Registrant or its stockholders for monetary damages for any breach of fiduciary duties as officers, except for
  liability in connection with (i)&nbsp;any breach of their duty of loyalty to the Registrant or the Registrant&#146;s stockholders, (ii)&nbsp;any act or omission not in good faith or that involves intentional misconduct or a knowing violation of law,
  (iii)&nbsp;any transaction from which they derived an improper personal benefit, or (iv)&nbsp;any action by or in the right of the Registrant. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:10pt; font-family:Calibri">If Delaware law is
  amended to authorize corporate action further eliminating or limiting the personal liability of directors or officers, then the liability of the Registrant&#146;s directors and officers will be eliminated or limited to the fullest extent permitted
  by Delaware law, as so amended. The Registrant&#146;s restated certificate of incorporation does not eliminate a director&#146;s or officer&#146;s duty of care and, in appropriate circumstances, equitable remedies, such as injunctive or other forms
  of nonmonetary relief, remain available under Delaware law. It also does not affect a director&#146;s or officer&#146;s responsibilities under any other laws, such as the federal securities laws or other state or federal laws. Under the
  Registrant&#146;s restated certificate of incorporation, the Registrant will also be empowered to enter into indemnification agreements with its directors, officers, employees and other agents and to purchase insurance on behalf of any person whom
  the Registrant is required or permitted to indemnify. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:10pt; font-family:Calibri">The Registrant entered into indemnification agreements with its directors and executive officers, in
  addition to the indemnification provided for in its restated certificate of incorporation, and intends to enter into indemnification agreements with any new directors and executive officers in the future. These agreements provide for the
  indemnification of such persons for all reasonable expenses and liabilities incurred in connection with any action or proceeding brought against them by reason of the fact that they are or were serving in such capacity. The Registrant believes that
  these restated certificate of incorporation provisions and indemnification agreements are necessary to attract and retain qualified persons as directors, officers and employees. </P>
  <P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:10pt; font-family:Calibri">The Registrant has purchased and intends to maintain insurance on behalf of any person who is or was a director or officer of the Registrant against any loss arising
  from any claim asserted against him or her and incurred by him or her in any such capacity, subject to certain exclusions. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:10pt; font-family:Calibri">The limitation of liability and
  indemnification provisions in the Registrant&#146;s restated certificate of incorporation may discourage stockholders from bringing a lawsuit against directors or officers for breach of their fiduciary duties. They may also reduce the likelihood of
  derivative litigation against directors and officers, even though an action, if successful, might benefit the Registrant and its stockholders. A stockholder&#146;s investment may be harmed to the extent the Registrant pays the costs of settlement
  and damage awards against directors and officers pursuant to these indemnification provisions. Insofar as indemnification for liabilities arising under the Securities Act may be permitted to the Registrant&#146;s directors, officers and controlling
  persons pursuant to the foregoing provisions, or otherwise, the Registrant has been advised that, in the opinion of the Commission, such indemnification is against public policy as expressed in the Securities Act, and is, therefore, unenforceable.
  </P>
  </DIV></Center>
  
  
  <p style="margin-top:1em; margin-bottom:0em; page-break-before:always"> </p>
  <HR SIZE="3" style="COLOR:#999999" WIDTH="100%" ALIGN="CENTER">
  
  
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   <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Calibri"><B>Item&#8201;7. Exemption from Registration Claimed. </B></P>
  <P STYLE="margin-top:6pt; margin-bottom:0pt; font-size:10pt; font-family:Calibri">Not applicable. </P> <P STYLE="margin-top:18pt; margin-bottom:0pt; font-size:10pt; font-family:Calibri"><B>Item&#8201;8. Exhibits. </B></P>
  <P STYLE="font-size:12pt;margin-top:0pt;margin-bottom:0pt">&nbsp;</P>
  <TABLE CELLSPACING="0" CELLPADDING="0" WIDTH="100%" BORDER="0" STYLE="BORDER-COLLAPSE:COLLAPSE; font-family:arial; font-size:10pt" ALIGN="center">
  
  
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  <TD VALIGN="bottom" NOWRAP ALIGN="center"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; border-bottom:1.00pt solid #000000; display:table-cell; font-size:8pt; font-family:Calibri; " ALIGN="center"><B>Exhibit<BR>Number</B></P></TD>
  <TD VALIGN="bottom">&nbsp;&nbsp;</TD>
  <TD VALIGN="bottom" NOWRAP ALIGN="center"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; border-bottom:1.00pt solid #000000; display:table-cell; font-size:8pt; font-family:Calibri; " ALIGN="center"><B>Exhibit Description</B></P></TD>
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  <TD VALIGN="bottom" COLSPAN="2" NOWRAP ALIGN="center"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; border-bottom:1.00pt solid #000000; display:table-cell; font-size:8pt; font-family:Calibri; " ALIGN="center"><B>Form</B></P></TD>
  <TD VALIGN="bottom">&nbsp;</TD>
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  <TD VALIGN="bottom" COLSPAN="2" NOWRAP ALIGN="center"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; border-bottom:1.00pt solid #000000; display:table-cell; font-size:8pt; font-family:Calibri; " ALIGN="center"><B>File Number</B></P></TD>
  <TD VALIGN="bottom">&nbsp;</TD>
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  <TD VALIGN="bottom" COLSPAN="2" NOWRAP ALIGN="center"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; border-bottom:1.00pt solid #000000; display:table-cell; font-size:8pt; font-family:Calibri; " ALIGN="center"><B>Exhibit<BR>Number</B></P></TD>
  <TD VALIGN="bottom">&nbsp;</TD>
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  <TD VALIGN="bottom" NOWRAP ALIGN="center"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; border-bottom:1.00pt solid #000000; display:table-cell; font-size:8pt; font-family:Calibri; " ALIGN="center"><B>Filing Date</B></P></TD>
  <TD VALIGN="bottom">&nbsp;&nbsp;</TD>
  <TD VALIGN="bottom" NOWRAP ALIGN="center"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; border-bottom:1.00pt solid #000000; display:table-cell; font-size:8pt; font-family:Calibri; " ALIGN="center"><B>Filed<BR>Herewith</B></P></TD></TR>
  
  
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  <TR STYLE="page-break-inside:avoid ; font-family:arial; font-size:10pt">
  <TD VALIGN="top" NOWRAP><FONT STYLE="font-family:Calibri; ">4.1</FONT></TD>
  <TD VALIGN="bottom">&nbsp;&nbsp;</TD>
  <TD VALIGN="top"><FONT STYLE="font-family:Calibri; "><A HREF="http://www.sec.gov/Archives/edgar/data/1672619/000119312523173982/d473990dex41.htm">Form of Specimen Common Stock Certificate (incorporated by reference)</A></FONT></TD>
  <TD VALIGN="bottom">&nbsp;&nbsp;</TD>
  <TD VALIGN="bottom"><FONT STYLE="font-family:Calibri; ">&nbsp;</FONT></TD>
  <TD VALIGN="bottom" ALIGN="right"><FONT STYLE="font-family:Calibri; "><FONT STYLE="white-space:nowrap">S-3</FONT></FONT></TD>
  <TD NOWRAP VALIGN="bottom"><FONT STYLE="font-family:Calibri; ">&nbsp;</FONT></TD>
  <TD VALIGN="bottom">&nbsp;&nbsp;</TD>
  <TD VALIGN="bottom"><FONT STYLE="font-family:Calibri; ">&nbsp;</FONT></TD>
  <TD VALIGN="bottom" ALIGN="right"><FONT STYLE="font-family:Calibri; "><FONT STYLE="white-space:nowrap">333-272909</FONT></FONT></TD>
  <TD NOWRAP VALIGN="bottom"><FONT STYLE="font-family:Calibri; ">&nbsp;</FONT></TD>
  <TD VALIGN="bottom">&nbsp;&nbsp;</TD>
  <TD VALIGN="bottom"><FONT STYLE="font-family:Calibri; ">&nbsp;</FONT></TD>
  <TD VALIGN="bottom" ALIGN="right"><FONT STYLE="font-family:Calibri; ">4.1</FONT></TD>
  <TD NOWRAP VALIGN="bottom"><FONT STYLE="font-family:Calibri; ">&nbsp;</FONT></TD>
  <TD VALIGN="bottom">&nbsp;&nbsp;</TD>
  <TD VALIGN="bottom" ALIGN="center"><FONT STYLE="font-family:Calibri; ">June&nbsp;23,&nbsp;2023</FONT></TD>
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  <TR STYLE="page-break-inside:avoid ; font-family:arial; font-size:10pt">
  <TD VALIGN="top" NOWRAP><FONT STYLE="font-family:Calibri; ">5.1</FONT></TD>
  <TD VALIGN="bottom">&nbsp;&nbsp;</TD>
  <TD VALIGN="top"><FONT STYLE="font-family:Calibri; "><A HREF="d897427dex51.htm">Opinion of Wilson Sonsini Goodrich&nbsp;&amp; Rosati, Professional Corporation </A></FONT></TD>
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  <TD VALIGN="bottom">&nbsp;&nbsp;</TD>
  <TD VALIGN="bottom" ALIGN="center"><FONT STYLE="font-family:Calibri; ">X</FONT></TD></TR>
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  <TD HEIGHT="8"></TD>
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  <TR STYLE="page-break-inside:avoid ; font-family:arial; font-size:10pt">
  <TD VALIGN="top" NOWRAP><FONT STYLE="font-family:Calibri; ">23.1</FONT></TD>
  <TD VALIGN="bottom">&nbsp;&nbsp;</TD>
  <TD VALIGN="top"><FONT STYLE="font-family:Calibri; "><A HREF="d897427dex231.htm">Consent of Deloitte&nbsp;&amp; Touche LLP, Independent Registered Public Accounting Firm </A></FONT></TD>
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  <TD VALIGN="bottom" ALIGN="center"><FONT STYLE="font-family:Calibri; ">X</FONT></TD></TR>
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  <TD VALIGN="top" NOWRAP><FONT STYLE="font-family:Calibri; ">23.2</FONT></TD>
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  <TD VALIGN="top"><FONT STYLE="font-family:Calibri; "><A HREF="d897427dex51.htm">Consent of Wilson Sonsini Goodrich&nbsp;&amp; Rosati, Professional Corporation (contained in Exhibit 5.1 hereto) </A></FONT></TD>
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  <TD VALIGN="bottom" ALIGN="center"><FONT STYLE="font-family:Calibri; ">X</FONT></TD></TR>
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  <TR STYLE="page-break-inside:avoid ; font-family:arial; font-size:10pt">
  <TD VALIGN="top" NOWRAP><FONT STYLE="font-family:Calibri; ">24.1</FONT></TD>
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  <TD VALIGN="top"><FONT STYLE="font-family:Calibri; "><A HREF="#sig">Power of Attorney (included on the signature page hereto) </A></FONT></TD>
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  <TD VALIGN="bottom" ALIGN="center"><FONT STYLE="font-family:Calibri; ">X</FONT></TD></TR>
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  <TD VALIGN="top" NOWRAP><FONT STYLE="font-family:Calibri; ">99.1</FONT></TD>
  <TD VALIGN="bottom">&nbsp;&nbsp;</TD>
  <TD VALIGN="top"><FONT STYLE="font-family:Calibri; "><A HREF="http://www.sec.gov/Archives/edgar/data/1672619/000119312524163507/d853800dex101.htm">The Registrant&#146;s Amended and Restated 2020 Equity Incentive Plan (incorporated by
  reference)</A></FONT></TD>
  <TD VALIGN="bottom">&nbsp;&nbsp;</TD>
  <TD VALIGN="bottom"><FONT STYLE="font-family:Calibri; ">&nbsp;</FONT></TD>
  <TD VALIGN="bottom" ALIGN="right"><FONT STYLE="font-family:Calibri; "><FONT STYLE="white-space:nowrap">8-K</FONT></FONT></TD>
  <TD NOWRAP VALIGN="bottom"><FONT STYLE="font-family:Calibri; ">&nbsp;</FONT></TD>
  <TD VALIGN="bottom">&nbsp;&nbsp;</TD>
  <TD VALIGN="bottom"><FONT STYLE="font-family:Calibri; ">&nbsp;</FONT></TD>
  <TD VALIGN="bottom" ALIGN="right"><FONT STYLE="font-family:Calibri; "><FONT STYLE="white-space:nowrap">001-39247</FONT></FONT></TD>
  <TD NOWRAP VALIGN="bottom"><FONT STYLE="font-family:Calibri; ">&nbsp;</FONT></TD>
  <TD VALIGN="bottom">&nbsp;&nbsp;</TD>
  <TD VALIGN="bottom"><FONT STYLE="font-family:Calibri; ">&nbsp;</FONT></TD>
  <TD VALIGN="bottom" ALIGN="right"><FONT STYLE="font-family:Calibri; ">10.1</FONT></TD>
  <TD NOWRAP VALIGN="bottom"><FONT STYLE="font-family:Calibri; ">&nbsp;</FONT></TD>
  <TD VALIGN="bottom">&nbsp;&nbsp;</TD>
  <TD VALIGN="bottom" ALIGN="center"><FONT STYLE="font-family:Calibri; ">June&nbsp;18, 2024</FONT></TD>
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  <TD VALIGN="top" NOWRAP><FONT STYLE="font-family:Calibri; ">99.2</FONT></TD>
  <TD VALIGN="bottom">&nbsp;&nbsp;</TD>
  <TD VALIGN="top"><FONT STYLE="font-family:Calibri; "><A HREF="http://www.sec.gov/Archives/edgar/data/1672619/000119312520038557/d842128dex105.htm">Form of Stock Option Agreement under the Registrant&#146;s Amended and Restated 2020 Equity Incentive Plan
   (incorporated by reference)</A></FONT></TD>
  <TD VALIGN="bottom">&nbsp;&nbsp;</TD>
  <TD VALIGN="bottom"><FONT STYLE="font-family:Calibri; ">&nbsp;</FONT></TD>
  <TD VALIGN="bottom" ALIGN="right"><FONT STYLE="font-family:Calibri; "><FONT STYLE="white-space:nowrap">S-1</FONT></FONT></TD>
  <TD NOWRAP VALIGN="bottom"><FONT STYLE="font-family:Calibri; ">&nbsp;</FONT></TD>
  <TD VALIGN="bottom">&nbsp;&nbsp;</TD>
  <TD VALIGN="bottom"><FONT STYLE="font-family:Calibri; ">&nbsp;</FONT></TD>
  <TD VALIGN="bottom" ALIGN="right"><FONT STYLE="font-family:Calibri; "><FONT STYLE="white-space:nowrap">333-236465</FONT></FONT></TD>
  <TD NOWRAP VALIGN="bottom"><FONT STYLE="font-family:Calibri; ">&nbsp;</FONT></TD>
  <TD VALIGN="bottom">&nbsp;&nbsp;</TD>
  <TD VALIGN="bottom"><FONT STYLE="font-family:Calibri; ">&nbsp;</FONT></TD>
  <TD VALIGN="bottom" ALIGN="right"><FONT STYLE="font-family:Calibri; ">10.5</FONT></TD>
  <TD NOWRAP VALIGN="bottom"><FONT STYLE="font-family:Calibri; ">&nbsp;</FONT></TD>
  <TD VALIGN="bottom">&nbsp;&nbsp;</TD>
  <TD VALIGN="bottom" ALIGN="center"><FONT STYLE="font-family:Calibri; ">February&nbsp;14,&nbsp;2020</FONT></TD>
  <TD VALIGN="bottom">&nbsp;&nbsp;</TD>
  <TD VALIGN="bottom"></TD></TR>
  <TR STYLE="font-size:1pt">
  <TD HEIGHT="8"></TD>
  <TD HEIGHT="8" COLSPAN="2"></TD>
  <TD HEIGHT="8" COLSPAN="4"></TD>
  <TD HEIGHT="8" COLSPAN="4"></TD>
  <TD HEIGHT="8" COLSPAN="4"></TD>
  <TD HEIGHT="8" COLSPAN="2"></TD>
  <TD HEIGHT="8" COLSPAN="2"></TD></TR>
  <TR STYLE="page-break-inside:avoid ; font-family:arial; font-size:10pt">
  <TD VALIGN="top" NOWRAP><FONT STYLE="font-family:Calibri; ">99.3</FONT></TD>
  <TD VALIGN="bottom">&nbsp;&nbsp;</TD>
  <TD VALIGN="top"><FONT STYLE="font-family:Calibri; "><A HREF="http://www.sec.gov/Archives/edgar/data/1672619/000156459022010216/imra-ex107_713.htm">Form of Restricted Stock Unit Agreement under the Registrant&#146;s Amended and Restated 2020 Equity Incentive
   Plan (incorporated by reference)</A></FONT></TD>
  <TD VALIGN="bottom">&nbsp;&nbsp;</TD>
  <TD VALIGN="bottom"><FONT STYLE="font-family:Calibri; ">&nbsp;</FONT></TD>
  <TD VALIGN="bottom" ALIGN="right"><FONT STYLE="font-family:Calibri; "><FONT STYLE="white-space:nowrap">10-K</FONT></FONT></TD>
  <TD NOWRAP VALIGN="bottom"><FONT STYLE="font-family:Calibri; ">&nbsp;</FONT></TD>
  <TD VALIGN="bottom">&nbsp;&nbsp;</TD>
  <TD VALIGN="bottom"><FONT STYLE="font-family:Calibri; ">&nbsp;</FONT></TD>
  <TD VALIGN="bottom" ALIGN="right"><FONT STYLE="font-family:Calibri; "><FONT STYLE="white-space:nowrap">001-39247</FONT></FONT></TD>
  <TD NOWRAP VALIGN="bottom"><FONT STYLE="font-family:Calibri; ">&nbsp;</FONT></TD>
  <TD VALIGN="bottom">&nbsp;&nbsp;</TD>
  <TD VALIGN="bottom"><FONT STYLE="font-family:Calibri; ">&nbsp;</FONT></TD>
  <TD VALIGN="bottom" ALIGN="right"><FONT STYLE="font-family:Calibri; ">10.7</FONT></TD>
  <TD NOWRAP VALIGN="bottom"><FONT STYLE="font-family:Calibri; ">&nbsp;</FONT></TD>
  <TD VALIGN="bottom">&nbsp;&nbsp;</TD>
  <TD VALIGN="bottom" ALIGN="center"><FONT STYLE="font-family:Calibri; ">March&nbsp;15, 2022</FONT></TD>
  <TD VALIGN="bottom">&nbsp;&nbsp;</TD>
  <TD VALIGN="bottom"></TD></TR>
  <TR STYLE="font-size:1pt">
  <TD HEIGHT="8"></TD>
  <TD HEIGHT="8" COLSPAN="2"></TD>
  <TD HEIGHT="8" COLSPAN="4"></TD>
  <TD HEIGHT="8" COLSPAN="4"></TD>
  <TD HEIGHT="8" COLSPAN="4"></TD>
  <TD HEIGHT="8" COLSPAN="2"></TD>
  <TD HEIGHT="8" COLSPAN="2"></TD></TR>
  <TR STYLE="page-break-inside:avoid ; font-family:arial; font-size:10pt">
  <TD VALIGN="top" NOWRAP><FONT STYLE="font-family:Calibri; ">107.1</FONT></TD>
  <TD VALIGN="bottom">&nbsp;&nbsp;</TD>
  <TD VALIGN="top"><FONT STYLE="font-family:Calibri; "><A HREF="d897427dexfilingfees.htm">Filing Fee Table </A></FONT></TD>
  <TD VALIGN="bottom">&nbsp;&nbsp;</TD>
  <TD VALIGN="bottom"></TD>
  <TD VALIGN="bottom"></TD>
  <TD VALIGN="bottom"></TD>
  <TD VALIGN="bottom">&nbsp;&nbsp;</TD>
  <TD VALIGN="bottom"></TD>
  <TD VALIGN="bottom"></TD>
  <TD VALIGN="bottom"></TD>
  <TD VALIGN="bottom">&nbsp;&nbsp;</TD>
  <TD VALIGN="bottom"></TD>
  <TD VALIGN="bottom"></TD>
  <TD VALIGN="bottom"></TD>
  <TD VALIGN="bottom">&nbsp;&nbsp;</TD>
  <TD VALIGN="bottom"></TD>
  <TD VALIGN="bottom">&nbsp;&nbsp;</TD>
  <TD VALIGN="bottom" ALIGN="center"><FONT STYLE="font-family:Calibri; ">X</FONT></TD></TR>
  </TABLE> <P STYLE="margin-top:18pt; margin-bottom:0pt; font-size:10pt; font-family:Calibri"><B>Item&#8201;9. Undertakings. </B></P>
  <P STYLE="margin-top:6pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Calibri">(a) The undersigned Registrant hereby undertakes: </P>
  <P STYLE="margin-top:6pt; margin-bottom:0pt; text-indent:9%; font-size:10pt; font-family:Calibri">(1) to file, during any period in which offers or sales are being made, a post-effective amendment to this Registration Statement: </P>
  <P STYLE="margin-top:6pt; margin-bottom:0pt; text-indent:13%; font-size:10pt; font-family:Calibri">(i) to include any prospectus required by Section&nbsp;10(a)(3) of the Securities Act; </P>
  <P STYLE="margin-top:6pt; margin-bottom:0pt; text-indent:13%; font-size:10pt; font-family:Calibri">(ii) to reflect in the prospectus any facts or events arising after the effective date of the Registration Statement (or the most recent
  post-effective amendment thereof) which, individually or in the aggregate, represent a fundamental change in the information set forth in the Registration Statement. Notwithstanding the foregoing, any increase or decrease in volume of securities
  offered (if the total dollar value of securities offered would not exceed that which was registered) and any deviation from the low or high end of the estimated maximum offering range may be reflected in the form of prospectus filed with the
  Commission pursuant to Rule 424(b) if, in the aggregate, the changes in volume and price represent no more than a 20&nbsp;percent change in the maximum aggregate offering price set forth in the &#147;Calculation of Registration Fee&#148; table in
  the effective Registration Statement; and </P> <P STYLE="margin-top:6pt; margin-bottom:0pt; text-indent:13%; font-size:10pt; font-family:Calibri">(iii) to include any material information with respect to the plan of distribution not previously
  disclosed in the Registration Statement or any material change to such information in the Registration Statement; <I>provided</I>, <I>however</I>, that paragraphs (a)(1)(i) and (a)(1)(ii) do not apply if the information required to be included in a
  post-effective amendment by those paragraphs is contained in reports filed with or furnished to the Commission by the Registrant pursuant to Section&nbsp;13 or Section&nbsp;15(d) of the Exchange Act that are incorporated by reference in the
  Registration Statement. </P>
  </DIV></Center>
  
  
  <p style="margin-top:1em; margin-bottom:0em; page-break-before:always"> </p>
  <HR SIZE="3" style="COLOR:#999999" WIDTH="100%" ALIGN="CENTER">
  
  
  <Center><DIV STYLE="width:8.5in" align="left">
   <P STYLE="margin-top:0pt; margin-bottom:0pt; text-indent:9%; font-size:10pt; font-family:Calibri">(2) that, for the purpose of determining any liability under the Securities Act, each such
  post-effective amendment shall be deemed to be a new registration statement relating to the securities offered therein, and the offering of such securities at that time shall be deemed to be the initial <I>bona fide</I> offering thereof. </P>
  <P STYLE="margin-top:6pt; margin-bottom:0pt; text-indent:9%; font-size:10pt; font-family:Calibri">(3) to remove from registration by means of a post-effective amendment any of the securities being registered which remain unsold at the termination of
  the offering. </P> <P STYLE="margin-top:6pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Calibri">(b) The undersigned Registrant hereby undertakes that, for purposes of determining any liability under the Securities Act, each
  filing of the Registrant&#146;s annual report pursuant to Section&nbsp;13(a) or 15(d) of the Exchange Act (and, where applicable, each filing of an employee benefit plan&#146;s annual report pursuant to Section&nbsp;15(d) of the Exchange Act) that
  is incorporated by reference in the Registration Statement shall be deemed to be a new registration statement relating to the securities offered therein, and the offering of such securities at that time shall be deemed to be the initial <I>bona
  fide</I> offering thereof. </P> <P STYLE="margin-top:6pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Calibri">(c) Insofar as indemnification for liabilities arising under the Securities Act may be permitted to directors, officers
  and controlling persons of the Registrant pursuant to the foregoing provisions, or otherwise, the Registrant has been advised that in the opinion of the Commission such indemnification is against public policy as expressed in the Securities Act and
  is, therefore, unenforceable. In the event that a claim for indemnification against such liabilities (other than the payment by the Registrant of expenses incurred or paid by a director, officer or controlling person of the Registrant in the
  successful defense of any action, suit or proceeding) is asserted by such director, officer or controlling person in connection with the securities being registered, the Registrant will, unless in the opinion of its counsel the matter has been
  settled by controlling precedent, submit to a court of appropriate jurisdiction the question whether such indemnification by it is against public policy as expressed in the Securities Act and will be governed by the final adjudication of such issue.
  </P>
  </DIV></Center>
  
  
  <p style="margin-top:1em; margin-bottom:0em; page-break-before:always"> </p>
  <HR SIZE="3" style="COLOR:#999999" WIDTH="100%" ALIGN="CENTER">
  
  
  <Center><DIV STYLE="width:8.5in" align="left">
   <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Calibri" ALIGN="center"><B>SIGNATURES </B></P>
  <P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:10pt; font-family:Calibri">Pursuant to the requirements of the Securities Act of 1933, as amended, the Registrant certifies that it has reasonable grounds to believe that it meets all of the
  requirements for filing on Form <FONT STYLE="white-space:nowrap">S-8</FONT> and has duly caused this Registration Statement to be signed on its behalf by the undersigned, thereunto duly authorized, in the City of Boulder, State of Colorado, on
  March&nbsp;13, 2025. </P> <P STYLE="font-size:12pt;margin-top:0pt;margin-bottom:0pt">&nbsp;</P>
  <TABLE CELLSPACING="0" CELLPADDING="0" WIDTH="40%" BORDER="0" STYLE="BORDER-COLLAPSE:COLLAPSE; font-family:arial; font-size:10pt">
  
  
  <TR>
  
  <TD WIDTH="6%"></TD>
  
  <TD VALIGN="bottom" WIDTH="1%"></TD>
  <TD WIDTH="93%"></TD></TR>
  
  
  <TR STYLE="page-break-inside:avoid ; font-family:arial; font-size:10pt">
  <TD VALIGN="top" COLSPAN="3"><FONT STYLE="font-family:Calibri; "><B>ENLIVEN THERAPEUTICS, INC.</B></FONT></TD></TR>
  <TR STYLE="font-size:1pt">
  <TD HEIGHT="16"></TD>
  <TD HEIGHT="16" COLSPAN="2"></TD></TR>
  <TR STYLE="page-break-inside:avoid ; font-family:arial; font-size:10pt">
  <TD VALIGN="top"><FONT STYLE="font-family:Calibri; ">By:</FONT></TD>
  <TD VALIGN="bottom">&nbsp;</TD>
  <TD VALIGN="top"> <P STYLE="margin-top:0pt; margin-bottom:1pt; border-bottom:1px solid #000000; font-size:10pt; font-family:Calibri">/s/ Samuel Kintz</P></TD></TR>
  <TR STYLE="page-break-inside:avoid ; font-family:arial; font-size:10pt">
  <TD VALIGN="top"></TD>
  <TD VALIGN="bottom">&nbsp;</TD>
  <TD VALIGN="top"><FONT STYLE="font-family:Calibri; ">Samuel Kintz</FONT></TD></TR>
  <TR STYLE="page-break-inside:avoid ; font-family:arial; font-size:10pt">
  <TD VALIGN="top"></TD>
  <TD VALIGN="bottom">&nbsp;</TD>
  <TD VALIGN="top"><FONT STYLE="font-family:Calibri; ">President and Chief Executive Officer</FONT></TD></TR>
  </TABLE> <P STYLE="margin-top:24pt; margin-bottom:0pt; font-size:10pt; font-family:Calibri" ALIGN="center"><B><A NAME="sig"></A>POWER OF ATTORNEY </B></P>
  <P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:10pt; font-family:Calibri">KNOW ALL PERSONS BY THESE PRESENTS, that each person whose signature appears below hereby constitutes and appoints Samuel Kintz and Benjamin Hohl, and each of them,
  as his or her true and lawful <FONT STYLE="white-space:nowrap"><FONT STYLE="white-space:nowrap">attorney-in-fact</FONT></FONT> and agent, with full power of substitution and resubstitution, for him or her and in his or her name, place and stead, in
  any and all capacities, to sign any and all amendments to this registration statement, including post-effective amendments, and to file the same, with all exhibits thereto, and all other documents in connection therewith, with the Securities and
  Exchange Commission, granting unto said <FONT STYLE="white-space:nowrap"><FONT STYLE="white-space:nowrap">attorney-in-fact</FONT></FONT> and agent and each of them, full power and authority to do and perform each and every act and thing requisite
  and necessary to be done in connection therewith and about the premises, as fully for all intents and purposes as they, he or she might or could do in person, hereby ratifying and confirming all that said <FONT STYLE="white-space:nowrap"><FONT
  STYLE="white-space:nowrap">attorney-in-fact</FONT></FONT> and agent or any of them, or their, his or her substitute or substitutes, may lawfully do or cause to be done by virtue hereof. </P>
  <P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:10pt; font-family:Calibri">Pursuant to the requirements of the Securities Act of 1933, this registration statement has been signed by the following persons in the capacities and on the dates
  indicated. </P> <P STYLE="font-size:12pt;margin-top:0pt;margin-bottom:0pt">&nbsp;</P>
  <TABLE CELLSPACING="0" CELLPADDING="0" WIDTH="100%" BORDER="0" STYLE="BORDER-COLLAPSE:COLLAPSE; font-family:arial; font-size:10pt" ALIGN="center">
  
  
  <TR>
  
  <TD WIDTH="35%"></TD>
  
  <TD VALIGN="bottom" WIDTH="1%"></TD>
  <TD WIDTH="32%"></TD>
  
  <TD VALIGN="bottom" WIDTH="1%"></TD>
  <TD WIDTH="31%"></TD></TR>
  <TR STYLE="page-break-inside:avoid ; font-family:arial; font-size:8pt">
  <TD VALIGN="bottom" NOWRAP STYLE="border-bottom:1.00pt solid #000000"> <P STYLE="margin-top:0pt; margin-bottom:1pt; font-size:8pt; font-family:Calibri"><B>Signature</B></P></TD>
  <TD VALIGN="bottom">&nbsp;&nbsp;</TD>
  <TD VALIGN="bottom" ALIGN="center" STYLE="border-bottom:1.00pt solid #000000"> <P STYLE="margin-top:0pt; margin-bottom:1pt; font-size:8pt; font-family:Calibri" ALIGN="center"><B>Title</B></P></TD>
  <TD VALIGN="bottom">&nbsp;&nbsp;</TD>
  <TD VALIGN="bottom" ALIGN="center" STYLE="border-bottom:1.00pt solid #000000"> <P STYLE="margin-top:0pt; margin-bottom:1pt; font-size:8pt; font-family:Calibri" ALIGN="center"><B>Date</B></P></TD></TR>
  
  
  <TR STYLE="font-size:1pt">
  <TD HEIGHT="16"></TD>
  <TD HEIGHT="16" COLSPAN="2"></TD>
  <TD HEIGHT="16" COLSPAN="2"></TD></TR>
  <TR STYLE="page-break-inside:avoid ; font-family:arial; font-size:10pt">
  <TD VALIGN="top"> <P STYLE="margin-top:0pt; margin-bottom:0pt; border-bottom:1px solid #000000; font-size:10pt; font-family:Calibri">/s/ Samuel Kintz</P> <P STYLE="margin-top:0pt; margin-bottom:1pt; font-size:10pt; font-family:Calibri">Samuel
  Kintz</P></TD>
  <TD VALIGN="bottom">&nbsp;&nbsp;</TD>
  <TD VALIGN="top"> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Calibri">President, Chief Executive Officer and Director</P> <P STYLE="margin-top:0pt; margin-bottom:1pt; font-size:10pt; font-family:Calibri">(Principal
  Executive Officer)</P></TD>
  <TD VALIGN="bottom">&nbsp;&nbsp;</TD>
  <TD VALIGN="top" ALIGN="center"><FONT STYLE="font-family:Calibri; ">March&nbsp;13, 2025</FONT></TD></TR>
  <TR STYLE="font-size:1pt">
  <TD HEIGHT="16"></TD>
  <TD HEIGHT="16" COLSPAN="2"></TD>
  <TD HEIGHT="16" COLSPAN="2"></TD></TR>
  <TR STYLE="page-break-inside:avoid ; font-family:arial; font-size:10pt">
  <TD VALIGN="top"> <P STYLE="margin-top:0pt; margin-bottom:0pt; border-bottom:1px solid #000000; font-size:10pt; font-family:Calibri">/s/ Benjamin Hohl</P> <P STYLE="margin-top:0pt; margin-bottom:1pt; font-size:10pt; font-family:Calibri">Benjamin
  Hohl</P></TD>
  <TD VALIGN="bottom">&nbsp;&nbsp;</TD>
  <TD VALIGN="top"> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Calibri">Chief Financial Officer and Head of Corporate Development</P>
  <P STYLE="margin-top:0pt; margin-bottom:1pt; font-size:10pt; font-family:Calibri">(Principal Financial and Accounting Officer)</P></TD>
  <TD VALIGN="bottom">&nbsp;&nbsp;</TD>
  <TD VALIGN="top" ALIGN="center"><FONT STYLE="font-family:Calibri; ">March&nbsp;13, 2025</FONT></TD></TR>
  <TR STYLE="font-size:1pt">
  <TD HEIGHT="16"></TD>
  <TD HEIGHT="16" COLSPAN="2"></TD>
  <TD HEIGHT="16" COLSPAN="2"></TD></TR>
  <TR STYLE="page-break-inside:avoid ; font-family:arial; font-size:10pt">
  <TD VALIGN="top"> <P STYLE="margin-top:0pt; margin-bottom:0pt; border-bottom:1px solid #000000; font-size:10pt; font-family:Calibri">/s/ Richard Heyman</P> <P STYLE="margin-top:0pt; margin-bottom:1pt; font-size:10pt; font-family:Calibri">Richard
  Heyman, Ph.D.</P></TD>
  <TD VALIGN="bottom">&nbsp;&nbsp;</TD>
  <TD VALIGN="top"><FONT STYLE="font-family:Calibri; ">Chairman of the Board of Directors and Director</FONT></TD>
  <TD VALIGN="bottom">&nbsp;&nbsp;</TD>
  <TD VALIGN="top" ALIGN="center"><FONT STYLE="font-family:Calibri; ">March&nbsp;13, 2025</FONT></TD></TR>
  <TR STYLE="font-size:1pt">
  <TD HEIGHT="16"></TD>
  <TD HEIGHT="16" COLSPAN="2"></TD>
  <TD HEIGHT="16" COLSPAN="2"></TD></TR>
  <TR STYLE="page-break-inside:avoid ; font-family:arial; font-size:10pt">
  <TD VALIGN="top"> <P STYLE="margin-top:0pt; margin-bottom:0pt; border-bottom:1px solid #000000; font-size:10pt; font-family:Calibri">/s/ Rahul Ballal</P> <P STYLE="margin-top:0pt; margin-bottom:1pt; font-size:10pt; font-family:Calibri">Rahul Ballal,
  Ph.D.</P></TD>
  <TD VALIGN="bottom">&nbsp;&nbsp;</TD>
  <TD VALIGN="top"><FONT STYLE="font-family:Calibri; ">Director</FONT></TD>
  <TD VALIGN="bottom">&nbsp;&nbsp;</TD>
  <TD VALIGN="top" ALIGN="center"><FONT STYLE="font-family:Calibri; ">March&nbsp;13, 2025</FONT></TD></TR>
  <TR STYLE="font-size:1pt">
  <TD HEIGHT="16"></TD>
  <TD HEIGHT="16" COLSPAN="2"></TD>
  <TD HEIGHT="16" COLSPAN="2"></TD></TR>
  <TR STYLE="page-break-inside:avoid ; font-family:arial; font-size:10pt">
  <TD VALIGN="top"> <P STYLE="margin-top:0pt; margin-bottom:0pt; border-bottom:1px solid #000000; font-size:10pt; font-family:Calibri">/s/ Jacob Bauer</P> <P STYLE="margin-top:0pt; margin-bottom:1pt; font-size:10pt; font-family:Calibri">Jacob
  Bauer</P></TD>
  <TD VALIGN="bottom">&nbsp;&nbsp;</TD>
  <TD VALIGN="top"><FONT STYLE="font-family:Calibri; ">Director</FONT></TD>
  <TD VALIGN="bottom">&nbsp;&nbsp;</TD>
  <TD VALIGN="top" ALIGN="center"><FONT STYLE="font-family:Calibri; ">March&nbsp;13, 2025</FONT></TD></TR>
  </TABLE>
  </DIV></Center>
  
  
  <p style="margin-top:1em; margin-bottom:0em; page-break-before:always"> </p>
  <HR SIZE="3" style="COLOR:#999999" WIDTH="100%" ALIGN="CENTER">
  
  
  <Center><DIV STYLE="width:8.5in" align="left">
  
  <TABLE CELLSPACING="0" CELLPADDING="0" WIDTH="100%" BORDER="0" STYLE="BORDER-COLLAPSE:COLLAPSE; font-family:arial; font-size:10pt" ALIGN="center">
  
  
  <TR>
  
  <TD WIDTH="35%"></TD>
  
  <TD VALIGN="bottom" WIDTH="1%"></TD>
  <TD WIDTH="32%"></TD>
  
  <TD VALIGN="bottom" WIDTH="1%"></TD>
  <TD WIDTH="31%"></TD></TR>
  
  
  <TR STYLE="page-break-inside:avoid ; font-family:arial; font-size:10pt">
  <TD VALIGN="top"> <P STYLE="margin-top:0pt; margin-bottom:0pt; border-bottom:1px solid #000000; font-size:10pt; font-family:Calibri">/s/ Rishi Gupta</P> <P STYLE="margin-top:0pt; margin-bottom:1pt; font-size:10pt; font-family:Calibri">Rishi Gupta,
  J.D.</P></TD>
  <TD VALIGN="bottom">&nbsp;&nbsp;</TD>
  <TD VALIGN="top"><FONT STYLE="font-family:Calibri; ">Director</FONT></TD>
  <TD VALIGN="bottom">&nbsp;&nbsp;</TD>
  <TD VALIGN="top" ALIGN="center"><FONT STYLE="font-family:Calibri; ">March&nbsp;13, 2025</FONT></TD></TR>
  <TR STYLE="font-size:1pt">
  <TD HEIGHT="16"></TD>
  <TD HEIGHT="16" COLSPAN="2"></TD>
  <TD HEIGHT="16" COLSPAN="2"></TD></TR>
  <TR STYLE="page-break-inside:avoid ; font-family:arial; font-size:10pt">
  <TD VALIGN="top"> <P STYLE="margin-top:0pt; margin-bottom:0pt; border-bottom:1px solid #000000; font-size:10pt; font-family:Calibri">/s/ Lori Kunkel</P> <P STYLE="margin-top:0pt; margin-bottom:1pt; font-size:10pt; font-family:Calibri">Lori Kunkel,
  M.D.</P></TD>
  <TD VALIGN="bottom">&nbsp;&nbsp;</TD>
  <TD VALIGN="top"><FONT STYLE="font-family:Calibri; ">Director</FONT></TD>
  <TD VALIGN="bottom">&nbsp;&nbsp;</TD>
  <TD VALIGN="top" ALIGN="center"><FONT STYLE="font-family:Calibri; ">March&nbsp;13, 2025</FONT></TD></TR>
  <TR STYLE="font-size:1pt">
  <TD HEIGHT="16"></TD>
  <TD HEIGHT="16" COLSPAN="2"></TD>
  <TD HEIGHT="16" COLSPAN="2"></TD></TR>
  <TR STYLE="page-break-inside:avoid ; font-family:arial; font-size:10pt">
  <TD VALIGN="top"> <P STYLE="margin-top:0pt; margin-bottom:0pt; border-bottom:1px solid #000000; font-size:10pt; font-family:Calibri">/s/ Andrew Phillips</P> <P STYLE="margin-top:0pt; margin-bottom:1pt; font-size:10pt; font-family:Calibri">Andrew
  Phillips, Ph.D.</P></TD>
  <TD VALIGN="bottom">&nbsp;&nbsp;</TD>
  <TD VALIGN="top"><FONT STYLE="font-family:Calibri; ">Director</FONT></TD>
  <TD VALIGN="bottom">&nbsp;&nbsp;</TD>
  <TD VALIGN="top" ALIGN="center"><FONT STYLE="font-family:Calibri; ">March&nbsp;13, 2025</FONT></TD></TR>
  </TABLE>
  </DIV></Center>
  
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metadata_filer: {"company-data": {"conformed-name": "Enliven Therapeutics, Inc.", "cik": "0001672619", "assigned-sic": "2834", "organization-name": "03 Life Sciences", "irs-number": "811523849", "state-of-incorporation": "DE", "fiscal-year-end": "1231"}, "filing-values": {"form-type": "S-8", "act": "33", "file-number": "333-285799", "film-number": "25736734"}, "business-address": {"street1": "6200 LOOKOUT ROAD", "city": "BOULDER", "state": "CO", "zip": "80301", "phone": "720-647-8519"}, "mail-address": {"street1": "6200 LOOKOUT ROAD", "city": "BOULDER", "state": "CO", "zip": "80301"}, "former-company": {"former-conformed-name": "IMARA Inc.", "date-changed": "20160419"}}
text: S-8
  As filed with the Securities and Exchange Commission on March 13, 2025
  Registration
  No. 333-
  UNITED STATES
  SECURITIES AND EXCHANGE COMMISSION
  Washington, D.C. 20549
  FORM
  S-8
  REGISTRATION STATEMENT
  UNDER
  THE SECURITIES ACT OF
  1933
  Enliven Therapeutics, Inc.
  (Exact name
  of registrant as specified in its charter)
  Delaware
  81-1523849
  (State or other jurisdiction of
  incorporation or organization)
  (I.R.S. Employer
  Identification No.)
  6200 Lookout Road
  Boulder, CO
  80301
  (Address of Principal Executive Offices)
  (Zip Code)
  Enliven Therapeutics, Inc. Amended and Restated 2020 Equity Incentive Plan
  (Full title of the plan)
  Samuel Kintz
  President and Chief Executive Officer
  Enliven Therapeutics, Inc.
  6200 Lookout
  Road
  Boulder, CO 80301
  (Name and
  address of agent for service)
  (720)
  647-8519
  (Telephone number, including area code, of agent for service)
  Copies to:
  Tony Jeffries, Esq.
  Jennifer Knapp, Esq.
  Wilson Sonsini
  Goodrich & Rosati,
  Professional Corporation
  1155 Canyon Blvd, Suite 400
  Boulder, CO
  80302
  (303)
  256-5900
  Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, a
  non-accelerated
  filer, a
  smaller reporting company or an emerging growth company. See the definitions of "large accelerated filer," "accelerated filer," "smaller reporting company," and "emerging growth company" in Rule
  12b-2
  of the Exchange Act.
  Large accelerated filer
  ☐
  Accelerated filer
  ☐
  Non-accelerated
  filer
  ☒
  Smaller reporting company
  ☒
  Emerging growth company
  ☒
  If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for
  complying with any new or revised financial accounting standards provided pursuant to Section 7(a)(2)(B) of the Securities Act.
  ☐
  EXPLANATORY NOTE
  Enliven Therapeutics, Inc. (the "
  Registrant
  ") is filing this Registration Statement on Form
  S-8
  (the
  "
  Registration Statement
  ") with the Securities and Exchange Commission (the "
  Commission
  ") to register 2,202,140 additional shares of Common Stock reserved for issuance under the Registrant's Amended and Restated
  2020 Equity Incentive Plan (the "
  2020 Plan
  ").
  The number of shares of Common Stock reserved and available for issuance under the 2020 Plan is
  subject to an automatic annual increase on the first day of each fiscal year during the term of the plan, beginning with the fiscal year commencing on January 1, 2024, and continuing for each fiscal year until, and including, the fiscal year
  commencing on January 1, 2032, equal to the least of (i) 4.5% of the number of shares of the Registrant's Common Stock outstanding on the first day of such fiscal year or (ii) an amount determined by the Registrant's board of
  directors; provided that, subject to certain capitalization adjustments, up to 7,175,000 shares of Common Stock may be granted as "incentive stock options" under the 2020 Plan.
  Accordingly, contents of (i) the previous registration statement on Form
  S-8
  filed by the Registrant with the Commission
  on
  March
  12, 2020
  (File
  No. 333-237117),
  (ii) the previous registration statement
  on Form
  S-8
  filed by the Registrant with the Commission on
  August
  6, 2021
  (File
  No. 
  333-258538),
  (iii) the previous registration statement on Form
  S-8
  filed by the Registrant with the Commission on
  March
  15, 2022
  (File
  No. 
  333-263554),
  (iv) the previous registration statement on Form
  S-8
  filed by the Registrant with the Commission on
  March
  1, 2023
  (File
  No. 333-270188),
  (v) the previous registration statement on Form
  S-8
  filed by the Registrant with the Commission
  on
  March
  14, 2024
  (File
  No. 333-277949),
  and (vi) the previous registration statement on
  Form
  S-8
  filed by the Registrant with the Commission on
  June
  20, 2024
  (File
  No. 333-280322),
  (together, the "
  Previous Forms
  S-8
  "), including the information incorporated by reference therein and the periodic reports filed after
  the Previous Forms
  S-8
  to maintain current information about the Registrant, are incorporated by reference into this Registration Statement pursuant to General Instruction E of Form
  S-8.
  PART I
  INFORMATION REQUIRED IN THE SECTION 10(a) PROSPECTUS
  The
  information specified in Item 1 and Item 2 of Part I of Form
  S-8
  is omitted from this Registration Statement in accordance with the provisions of Rule 428 under the Securities Act of 1933, as amended (the
  "
  Securities Act
  ") and the introductory note to Part I of Form
  S-8.
  The documents containing the information specified in Part I of Form
  S-8
  will be
  delivered to the participants in the equity benefit plans covered by this Registration Statement as specified by Rule 428(b)(1) under the Securities Act. These documents and the documents incorporated by reference in this Registration Statement
  pursuant to Item 3 of Part II of Form
  S-8,
  taken together, constitute a prospectus that meets the requirements of Section 10(a) of the Securities Act.
  PART II
  INFORMATION REQUIRED IN THE
  REGISTRATION STATEMENT
  Item 3. Incorporation of Documents by Reference.
  The Registrant hereby incorporates by reference into this Registration Statement the following documents previously filed with the Commission:
  (1) The Registrant's Annual Report on
  Form
  10-K
  for the fiscal year ended December 31, 2024, filed with the Commission on March 13, 2025;
  (2) All
  other reports filed with the Commission pursuant to Section 13(a) or 15(d) of the Securities Exchange Act of 1934, as amended (the "
  Exchange Act
  "), since the end of the fiscal year covered by the Registrant's Annual Report
  on Form
  10-K
  referred to in (1) above; and
  (3) The description of the Registrant's Common Stock contained in
  the Registrant's registration statement on
  Form
  8-A
  , filed with the Commission on March 9, 2020
  pursuant to Section 
  12(b) of the Exchange Act, and as set forth by the description of the Registrant's Common Stock set forth in the Registrant's registration statement on
  Form
   S-4/A
  , filed with the Commission on January 
  9, 2023, and as set forth by the description of the Registrant's Common Stock set forth in
  Exhibit 4.2
  of the Registrant's Annual Report on
  Form
  10-K
  for the fiscal year ended December 31, 2023, filed with the Commission on March 14, 2024, including any amendment or report filed for the purpose of updating such description.
  All documents filed by the Registrant pursuant to Sections 13(a), 13(c), 14 and 15(d) of the Exchange Act on or after the date of this Registration Statement and
  prior to the filing of a post-effective amendment to this Registration Statement that indicates that all securities offered have been sold or that deregisters all securities then remaining unsold shall be deemed to be incorporated by reference in
  this Registration Statement and to be a part hereof from the date of filing of such documents;
  provided
  ,
  however
  , that documents or information deemed to have been furnished and not filed in accordance with the rules of the Commission
  shall not be deemed incorporated by reference into this Registration Statement. Any statement contained in a document incorporated or deemed to be incorporated by reference herein shall be deemed to be modified or superseded for purposes of this
  Registration Statement to the extent that a statement contained herein or in any subsequently filed document which also is deemed to be incorporated by reference herein modifies or supersedes such statement. Any such statement so modified or
  superseded shall not be deemed, except as so modified or superseded, to constitute a part of this Registration Statement.
  Item 4. Description of Securities.
  Not applicable.
  Item 5. Interests of Named Experts and Counsel.
  The validity of the shares of Common Stock offered hereby will be passed upon for the Registrant by Wilson Sonsini Goodrich & Rosati, Professional
  Corporation, Boulder, CO. Investment funds associated with Wilson Sonsini Goodrich & Rosati, Professional Corporation, hold an aggregate of 31,070 shares of Common Stock, which represent less than 1% of the Registrant's outstanding
  shares of Common Stock.
  Item 6. Indemnification of Directors and Officers.
  Subsection (a) of Section 145 of the Delaware General Corporation Law ("
  DGCL
  ") empowers a corporation to indemnify any person who was or is
  a party or who is threatened to be made a party to any threatened, pending or completed action, suit or proceeding, whether civil, criminal, administrative or investigative (other than an action by or in the right of the corporation) by reason of
  the fact that the person is or was a director, officer, employee or agent of the corporation, or is or was serving at the request of the corporation as a director, officer, employee or agent of another corporation, partnership, joint venture, trust
  or other enterprise, against expenses (including attorneys' fees), judgments, fines and amounts paid in settlement actually and reasonably incurred by the person in connection with such action, suit or proceeding if the person acted in good
  faith and in a manner the person reasonably believed to be in or not opposed to the best interests of the corporation, and, with respect to any criminal action or proceeding, had no reasonable cause to believe the person's conduct was unlawful.
  Subsection (b) of Section 145 empowers a corporation to indemnify any person who was or is a party or is threatened to be made a party to any
  threatened, pending or completed action or suit by or in the right of the corporation to procure a judgment in its favor by reason of the fact that the person acted in any of the capacities set forth above, against expenses (including
  attorneys' fees) actually and reasonably incurred by the person in connection with the defense or settlement of such action or suit if the person acted in good faith and in a manner the person reasonably believed to be in or not opposed to the
  best interests of the corporation, except that no indemnification shall be made in respect of any claim, issue or matter as to which such person shall have been adjudged to be liable to the corporation unless and only to the extent that the Delaware
  Court of Chancery or the court in which such action or suit was brought shall determine upon application that, despite the adjudication of liability but in view of all the circumstances of the case, such person is fairly and reasonably entitled to
  indemnity for such expenses which the Delaware Court of Chancery or such other court shall deem proper.
  Section 145 further provides that to the extent a
  present or former director or officer of a corporation has been successful on the merits or otherwise in the defense of any action, suit or proceeding referred to in subsections (a) and (b) of Section 145, or in defense of any claim, issue
  or matter therein, such person shall be indemnified against expenses (including attorneys' fees) actually and reasonably incurred by such person in connection therewith; that indemnification and advancement of expenses provided for by
  Section 145 shall not be deemed exclusive of any other rights to which the indemnified party may be entitled; and the indemnification and advancement of expenses provided for by Section 145 shall, unless otherwise provided when authorized
  or ratified, continue as to a person who has ceased to be a director, officer, employee or agent and shall inure to the benefit of such person's heirs, executors and administrators. Section 145 also empowers the corporation to purchase and
  maintain insurance on behalf of any person who is or was a director, officer, employee or agent of the corporation, or is or was serving at the request of the corporation as a director, officer, employee or agent of another corporation, partnership,
  joint venture, trust or other enterprise against any liability asserted against such person and incurred by such person in any such capacity, or arising out of his status as such, whether or not the corporation would have the power to indemnify such
  person against such liabilities under Section 145.
  Section 102(b)(7) of the DGCL provides that a corporation's certificate of incorporation may contain a
  provision eliminating or limiting the personal liability of a director or officer to the corporation or its stockholders for monetary damages for breach of fiduciary duty as a director or officer, with certain exceptions described below.
  The Registrant's restated certificate of incorporation contains provisions that eliminate, to the maximum extent permitted by the DGCL, the personal liability of
  directors and certain of its officers for monetary damages for breach of their fiduciary duties as a director or officer. The Registrant's restated certificate of incorporation provides that the Registrant shall indemnify its directors and
  officers and may indemnify its employees and other agents to the fullest extent permitted by the DGCL. However, the DGCL prohibits the Registrant from limiting the liability of directors for (i) any breach of a director's duty of loyalty
  to the Registrant or to the Registrant's stockholders, (ii) any act or omission not in good faith or that involves intentional misconduct or a knowing violation of law, (iii) unlawful payment of dividends or unlawful stock repurchases
  or redemptions as provided in Section 174 of the DGCL, or (iv) any transaction from which a director derived an improper personal benefit. Similarly, officers who at the time of an act or omission as to which liability is asserted
  consented to or are deemed to have consented to certain service of process rules under Delaware law will not be personally liable to the Registrant or its stockholders for monetary damages for any breach of fiduciary duties as officers, except for
  liability in connection with (i) any breach of their duty of loyalty to the Registrant or the Registrant's stockholders, (ii) any act or omission not in good faith or that involves intentional misconduct or a knowing violation of law,
  (iii) any transaction from which they derived an improper personal benefit, or (iv) any action by or in the right of the Registrant.
  If Delaware law is
  amended to authorize corporate action further eliminating or limiting the personal liability of directors or officers, then the liability of the Registrant's directors and officers will be eliminated or limited to the fullest extent permitted
  by Delaware law, as so amended. The Registrant's restated certificate of incorporation does not eliminate a director's or officer's duty of care and, in appropriate circumstances, equitable remedies, such as injunctive or other forms
  of nonmonetary relief, remain available under Delaware law. It also does not affect a director's or officer's responsibilities under any other laws, such as the federal securities laws or other state or federal laws. Under the
  Registrant's restated certificate of incorporation, the Registrant will also be empowered to enter into indemnification agreements with its directors, officers, employees and other agents and to purchase insurance on behalf of any person whom
  the Registrant is required or permitted to indemnify.
  The Registrant entered into indemnification agreements with its directors and executive officers, in
  addition to the indemnification provided for in its restated certificate of incorporation, and intends to enter into indemnification agreements with any new directors and executive officers in the future. These agreements provide for the
  indemnification of such persons for all reasonable expenses and liabilities incurred in connection with any action or proceeding brought against them by reason of the fact that they are or were serving in such capacity. The Registrant believes that
  these restated certificate of incorporation provisions and indemnification agreements are necessary to attract and retain qualified persons as directors, officers and employees.
  The Registrant has purchased and intends to maintain insurance on behalf of any person who is or was a director or officer of the Registrant against any loss arising
  from any claim asserted against him or her and incurred by him or her in any such capacity, subject to certain exclusions.
  The limitation of liability and
  indemnification provisions in the Registrant's restated certificate of incorporation may discourage stockholders from bringing a lawsuit against directors or officers for breach of their fiduciary duties. They may also reduce the likelihood of
  derivative litigation against directors and officers, even though an action, if successful, might benefit the Registrant and its stockholders. A stockholder's investment may be harmed to the extent the Registrant pays the costs of settlement
  and damage awards against directors and officers pursuant to these indemnification provisions. Insofar as indemnification for liabilities arising under the Securities Act may be permitted to the Registrant's directors, officers and controlling
  persons pursuant to the foregoing provisions, or otherwise, the Registrant has been advised that, in the opinion of the Commission, such indemnification is against public policy as expressed in the Securities Act, and is, therefore, unenforceable.
  Item 7. Exemption from Registration Claimed.
  Not applicable.
  Item 8. Exhibits.
  Exhibit
  Number
  Exhibit Description
  Form
  File Number
  Exhibit
  Number
  Filing Date
  Filed
  Herewith
  4.1
  Form of Specimen Common Stock Certificate (incorporated by reference)
  S-3
  333-272909
  4.1
  June 23, 2023
  5.1
  Opinion of Wilson Sonsini Goodrich & Rosati, Professional Corporation
  X
  23.1
  Consent of Deloitte & Touche LLP, Independent Registered Public Accounting Firm
  X
  23.2
  Consent of Wilson Sonsini Goodrich & Rosati, Professional Corporation (contained in Exhibit 5.1 hereto)
  X
  24.1
  Power of Attorney (included on the signature page hereto)
  X
  99.1
  The Registrant's Amended and Restated 2020 Equity Incentive Plan (incorporated by
  reference)
  8-K
  001-39247
  10.1
  June 18, 2024
  99.2
  Form of Stock Option Agreement under the Registrant's Amended and Restated 2020 Equity Incentive Plan
   (incorporated by reference)
  S-1
  333-236465
  10.5
  February 14, 2020
  99.3
  Form of Restricted Stock Unit Agreement under the Registrant's Amended and Restated 2020 Equity Incentive
   Plan (incorporated by reference)
  10-K
  001-39247
  10.7
  March 15, 2022
  107.1
  Filing Fee Table
  X
  Item 9. Undertakings.
  (a) The undersigned Registrant hereby undertakes:
  (1) to file, during any period in which offers or sales are being made, a post-effective amendment to this Registration Statement:
  (i) to include any prospectus required by Section 10(a)(3) of the Securities Act;
  (ii) to reflect in the prospectus any facts or events arising after the effective date of the Registration Statement (or the most recent
  post-effective amendment thereof) which, individually or in the aggregate, represent a fundamental change in the information set forth in the Registration Statement. Notwithstanding the foregoing, any increase or decrease in volume of securities
  offered (if the total dollar value of securities offered would not exceed that which was registered) and any deviation from the low or high end of the estimated maximum offering range may be reflected in the form of prospectus filed with the
  Commission pursuant to Rule 424(b) if, in the aggregate, the changes in volume and price represent no more than a 20 percent change in the maximum aggregate offering price set forth in the "Calculation of Registration Fee" table in
  the effective Registration Statement; and
  (iii) to include any material information with respect to the plan of distribution not previously
  disclosed in the Registration Statement or any material change to such information in the Registration Statement;
  provided
  ,
  however
  , that paragraphs (a)(1)(i) and (a)(1)(ii) do not apply if the information required to be included in a
  post-effective amendment by those paragraphs is contained in reports filed with or furnished to the Commission by the Registrant pursuant to Section 13 or Section 15(d) of the Exchange Act that are incorporated by reference in the
  Registration Statement.
  (2) that, for the purpose of determining any liability under the Securities Act, each such
  post-effective amendment shall be deemed to be a new registration statement relating to the securities offered therein, and the offering of such securities at that time shall be deemed to be the initial
  bona fide
  offering thereof.
  (3) to remove from registration by means of a post-effective amendment any of the securities being registered which remain unsold at the termination of
  the offering.
  (b) The undersigned Registrant hereby undertakes that, for purposes of determining any liability under the Securities Act, each
  filing of the Registrant's annual report pursuant to Section 13(a) or 15(d) of the Exchange Act (and, where applicable, each filing of an employee benefit plan's annual report pursuant to Section 15(d) of the Exchange Act) that
  is incorporated by reference in the Registration Statement shall be deemed to be a new registration statement relating to the securities offered therein, and the offering of such securities at that time shall be deemed to be the initial
  bona
  fide
  offering thereof.
  (c) Insofar as indemnification for liabilities arising under the Securities Act may be permitted to directors, officers
  and controlling persons of the Registrant pursuant to the foregoing provisions, or otherwise, the Registrant has been advised that in the opinion of the Commission such indemnification is against public policy as expressed in the Securities Act and
  is, therefore, unenforceable. In the event that a claim for indemnification against such liabilities (other than the payment by the Registrant of expenses incurred or paid by a director, officer or controlling person of the Registrant in the
  successful defense of any action, suit or proceeding) is asserted by such director, officer or controlling person in connection with the securities being registered, the Registrant will, unless in the opinion of its counsel the matter has been
  settled by controlling precedent, submit to a court of appropriate jurisdiction the question whether such indemnification by it is against public policy as expressed in the Securities Act and will be governed by the final adjudication of such issue.
  SIGNATURES
  Pursuant to the requirements of the Securities Act of 1933, as amended, the Registrant certifies that it has reasonable grounds to believe that it meets all of the
  requirements for filing on Form
  S-8
  and has duly caused this Registration Statement to be signed on its behalf by the undersigned, thereunto duly authorized, in the City of Boulder, State of Colorado, on
  March 13, 2025.
  ENLIVEN THERAPEUTICS, INC.
  By:
  /s/ Samuel Kintz
  Samuel Kintz
  President and Chief Executive Officer
  POWER OF ATTORNEY
  KNOW ALL PERSONS BY THESE PRESENTS, that each person whose signature appears below hereby constitutes and appoints Samuel Kintz and Benjamin Hohl, and each of them,
  as his or her true and lawful
  attorney-in-fact
  and agent, with full power of substitution and resubstitution, for him or her and in his or her name, place and stead, in
  any and all capacities, to sign any and all amendments to this registration statement, including post-effective amendments, and to file the same, with all exhibits thereto, and all other documents in connection therewith, with the Securities and
  Exchange Commission, granting unto said
  attorney-in-fact
  and agent and each of them, full power and authority to do and perform each and every act and thing requisite
  and necessary to be done in connection therewith and about the premises, as fully for all intents and purposes as they, he or she might or could do in person, hereby ratifying and confirming all that said
  attorney-in-fact
  and agent or any of them, or their, his or her substitute or substitutes, may lawfully do or cause to be done by virtue hereof.
  Pursuant to the requirements of the Securities Act of 1933, this registration statement has been signed by the following persons in the capacities and on the dates
  indicated.
  Signature
  Title
  Date
  /s/ Samuel Kintz
  Samuel
  Kintz
  President, Chief Executive Officer and Director
  (Principal
  Executive Officer)
  March 13, 2025
  /s/ Benjamin Hohl
  Benjamin
  Hohl
  Chief Financial Officer and Head of Corporate Development
  (Principal Financial and Accounting Officer)
  March 13, 2025
  /s/ Richard Heyman
  Richard
  Heyman, Ph.D.
  Chairman of the Board of Directors and Director
  March 13, 2025
  /s/ Rahul Ballal
  Rahul Ballal,
  Ph.D.
  Director
  March 13, 2025
  /s/ Jacob Bauer
  Jacob
  Bauer
  Director
  March 13, 2025
  /s/ Rishi Gupta
  Rishi Gupta,
  J.D.
  Director
  March 13, 2025
  /s/ Lori Kunkel
  Lori Kunkel,
  M.D.
  Director
  March 13, 2025
  /s/ Andrew Phillips
  Andrew
  Phillips, Ph.D.
  Director
  March 13, 2025