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  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>As filed with the Securities and Exchange Commission
  on June 26, 2023</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: right"><B>Registration No. 333-</B>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</P>
  
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  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: right"></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>UNITED STATES</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>SECURITIES AND EXCHANGE COMMISSION</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>Washington, D.C. 20549</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>FORM S-8</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>REGISTRATION STATEMENT</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B><I>UNDER</I></B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B><I>THE SECURITIES ACT OF 1933</I></B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>LONGEVERON INC.</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>(Exact name of registrant as specified in its
  charter)</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>
  
  <TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
    <TR>
      <TD STYLE="vertical-align: top; width: 49%; border-bottom: black 1.5pt solid; font-size: 10pt; text-align: center"><FONT STYLE="font-size: 10pt"><B>Delaware</B></FONT></TD>
      <TD STYLE="vertical-align: bottom; width: 2%; font-size: 10pt">&nbsp;</TD>
      <TD STYLE="vertical-align: top; width: 49%; border-bottom: black 1.5pt solid; font-size: 10pt; text-align: center"><FONT STYLE="font-size: 10pt"><B>47-2174146</B></FONT></TD></TR>
    <TR>
      <TD STYLE="vertical-align: top">
      <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">(State or other jurisdiction of</P>
      <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">incorporation or organization)</P></TD>
      <TD STYLE="vertical-align: bottom; font-size: 10pt">&nbsp;</TD>
      <TD STYLE="vertical-align: top">
      <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">(I.R.S. employer</P>
      <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">identification number)</P></TD></TR>
    </TABLE>
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>1951 NW 7<SUP>th</SUP> Avenue, Suite 520</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>Miami, Florida 33136</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>Telephone: (305) 909-0840</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">(Address, including zip code, and telephone number,
  including area code, of registrant&rsquo;s principal executive offices)</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>Amended and Restated Longeveron Inc. 2021 Incentive
  Award Plan</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">(Full title of the Plan)</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>Wa&rsquo;el Hashad</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>Chief Executive Officer </B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>Longeveron Inc.</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>1951 NW 7<SUP>th</SUP> Ave., Suite 520</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>Miami, FL 33136</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>(305) 909-0840</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">(Name, address, including zip code, and telephone
  number, including area code, of agent for service)</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B><I>Copies to:</I></B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>&nbsp;</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>Jennifer Minter, Esq.<BR>
  Adam G. Wicks, Esq.</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>Buchanan Ingersoll &amp; Rooney PC</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>Union Trust Building</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>501 Grant Street, Suite 200</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>Pittsburgh, PA 15219</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>(412) 562-8800</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
  
  <P STYLE="text-align: justify; font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Indicate by check mark whether the registrant is a large accelerated
  filer, an accelerated filer, a nonaccelerated filer, smaller reporting company, or an emerging growth company. See the definitions of
  &ldquo;large accelerated filer,&rdquo; &ldquo;accelerated filer,&rdquo; &ldquo;smaller reporting company,&rdquo; and &ldquo;emerging growth
  company&rdquo; in Rule 12b-2 of the Exchange Act.</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
  
  <TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
    <TR STYLE="vertical-align: bottom">
      <TD STYLE="width: 25%"><FONT STYLE="font-size: 10pt">Large Accelerated Filer</FONT></TD>
      <TD STYLE="width: 45%"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#9744;</FONT></TD>
      <TD STYLE="width: 25%"><FONT STYLE="font-size: 10pt">Accelerated filer</FONT></TD>
      <TD STYLE="width: 5%"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#9744;</FONT></TD></TR>
    <TR STYLE="vertical-align: bottom">
      <TD><FONT STYLE="font-size: 10pt">Non-accelerated filer</FONT></TD>
      <TD><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#9746;</FONT></TD>
      <TD><FONT STYLE="font-size: 10pt">Smaller reporting company</FONT></TD>
      <TD><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#9746;</FONT></TD></TR>
    <TR STYLE="vertical-align: bottom">
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD><FONT STYLE="font-size: 10pt">Emerging growth company</FONT></TD>
      <TD><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#9746;</FONT></TD></TR>
    </TABLE>
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
  
  <P STYLE="text-align: justify; font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">If an emerging growth company, indicate by check mark if the registrant
  has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant
  to Section 7(a)(2)(B) of the Securities Act. <FONT STYLE="font-family: Times New Roman, Times, Serif">&#9744;</FONT></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
  
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  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"></P>
  
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  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 5.9pt; text-align: center"><B>EXPLANATORY NOTE</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify">Longeveron Inc. (referred to as the &ldquo;Registrant,&rdquo;
  &ldquo;the Company,&rdquo; &ldquo;we,&rdquo; &ldquo;us&rdquo; or &ldquo;our&rdquo; unless specified otherwise) is filing this registration
  statement on Form S-8 (the &ldquo;Registration Statement&rdquo;) for the purpose of registering an additional 1,500,000 shares of our
  Class A Common Stock, par value $0.001 per share, for issuance under the Amended and Restated Longeveron Inc. 2021 Incentive Award Plan
  (the &ldquo;Plan&rdquo;). The 1,500,000 shares of Class A Common Stock being registered pursuant to this Registration Statement are in
  addition to the 2,074,402 shares of Class A Common Stock under the Plan currently registered on our Registration Statement on Form S-8
  filed on February 16, 2021, file number 333-253141 (the &ldquo;2021 Registration Statement&rdquo;). This Registration Statement relates
  to the same class of securities to which the 2021 Registration Statement relates and is submitted pursuant to General Instruction E to
  Form S-8. Pursuant to General Instruction E, this Registration Statement incorporates by reference the contents of the 2021 Registration
  Statement.</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"></P>
  
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  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>PART II</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>INFORMATION REQUIRED IN THE REGISTRATION STATEMENT</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B>Item 3. Incorporation of Documents by Reference.</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; background-color: white">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-right: 0; margin-bottom: 0pt; text-align: justify; background-color: white">In
  addition to the 2021 Registration Statement, the following documents, which have been heretofore filed by the Company with the SEC pursuant
  to the Securities Exchange Act of 1934 (the &ldquo;Exchange Act&rdquo;), other than any portions of the respective filings that were furnished,
  rather than filed, pursuant to Item 2.02 or Item 7.01 of Current Reports on Form 8-K (including exhibits related thereto) or other applicable
  SEC rules, shall be deemed incorporated by reference herein and to be a part of this Registration Statement from the date of filing of
  such documents:</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; background-color: white">&nbsp;</P>
  
  <TABLE CELLPADDING="0" CELLSPACING="0" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; width: 100%"><TR STYLE="vertical-align: top; text-align: justify">
  <TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in; text-align: left"><FONT STYLE="font-size: 10pt">(a)</FONT></TD><TD STYLE="text-align: justify"><FONT STYLE="font-size: 10pt">Our Annual Report on <A HREF="http://www.sec.gov/ix?doc=/Archives/edgar/data/1721484/000121390023020006/f10k2022_longeveron.htm">Form 10-K</A>
  for the fiscal year ended December 31, 2022 filed with the SEC on March 14, 2023;</FONT></TD>
  </TR></TABLE>
  
  <P STYLE="margin: 0">&nbsp;</P>
  
  <TABLE CELLPADDING="0" CELLSPACING="0" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; width: 100%"><TR STYLE="vertical-align: top; text-align: justify">
  <TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in; text-align: left"><FONT STYLE="font-size: 10pt">(b)</FONT></TD><TD STYLE="text-align: justify"><FONT STYLE="font-size: 10pt">All other reports filed by
  us pursuant to Section 13(a) or 15(d) of the Exchange Act since December 31, 2022 (in each case, except for the information furnished
  under Items 2.02 or 7.01 in any current report on Form 8-K); and</FONT></TD>
  </TR></TABLE>
  
  <P STYLE="margin: 0">&nbsp;</P>
  
  <TABLE CELLPADDING="0" CELLSPACING="0" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; width: 100%"><TR STYLE="vertical-align: top; text-align: justify">
  <TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in; text-align: left"><FONT STYLE="font-size: 10pt">(c)</FONT></TD><TD STYLE="text-align: justify"><FONT STYLE="font-size: 10pt">The description of the Registrant&rsquo;s
  common stock set forth in the Registrant&rsquo;s registration statement on <A HREF="http://www.sec.gov/Archives/edgar/data/1721484/000121390021008383/ea135165-8a12b_longeveron.htm">Form&nbsp;8-A</A>&nbsp;(File&nbsp;No.&nbsp;001-40060), filed by
  the Registrant with the SEC under Section&nbsp;12(b) of the Exchange Act on February 11, 2021, including&nbsp;<A HREF="http://www.sec.gov/Archives/edgar/data/1721484/000121390022011894/f10k2021ex4-2_longever.htm">Exhibit 4.2</A>&nbsp;to the
  Annual Report on Form&nbsp;10-K&nbsp;for the fiscal year ended December 31, 2022 filed with the SEC on March&nbsp;14, 2023 and any other
  amendments or reports filed for the purpose of updating such description.</FONT></TD>
  </TR></TABLE>
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; background-color: white">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; background-color: white">In addition, all documents
  filed by the Registrant pursuant to Section&nbsp;13(a), 13(c), 14 or 15(d) of the Exchange Act subsequent to the filing of this Registration
  Statement and prior to the filing of a post-effective amendment which indicates that all securities offered hereby have been sold or which
  de-registers all securities then remaining unsold shall be deemed to be incorporated by reference into this Registration Statement and
  to be a part hereof from the date of filing such documents, except as to specific sections of such statements as set forth therein. Any
  statement contained in a document incorporated or deemed to be incorporated by reference herein shall be deemed to be modified or superseded
  for purposes of this Registration Statement to the extent that a statement contained herein or in any other subsequently filed document
  which also is incorporated or deemed to be incorporated by reference herein modifies or supersedes such statement. Any statement contained
  herein shall be deemed to be modified or superseded for purposes of this Registration Statement to the extent that a statement contained
  in any subsequently filed document which also is incorporated or deemed to be incorporated by reference herein modifies or supersedes
  such statement. Any such statement so modified or superseded shall not be deemed, except as so modified or superseded, to constitute a
  part of this Registration Statement.</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; background-color: white">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; background-color: white">Under no circumstances
  shall any information furnished under Item 2.02 or 7.01 of Form&nbsp;8-K be deemed incorporated herein by reference unless such Form&nbsp;8-K
  expressly provides to the contrary.</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 27pt">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B>Item 5. Interests of Named Experts and Counsel.</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify">The validity of the securities registered hereby has
  been passed upon for the Company by Buchanan Ingersoll&nbsp;&amp; Rooney PC (&ldquo;Buchanan&rdquo;), Pittsburgh, Pennsylvania. Certain
  attorneys affiliated with Buchanan beneficially own an aggregate of 20,000 shares of our Class&nbsp;A Common Stock.</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"></P>
  
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  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B>Item 6. Indemnification of Directors and Officers.</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">Section 102 of the Delaware General Corporation
  Law (&ldquo;DGCL&rdquo;) permits a corporation to eliminate the personal liability of directors and officers of a corporation to the corporation
  or its stockholders for monetary damages for a breach of fiduciary duty as a director or officer, except where the director or officer
  breached his duty of loyalty, failed to act in good faith, engaged in intentional misconduct or knowingly violated a law, or obtained
  an improper personal benefit, or in the case of directors authorized the payment of a dividend or approved a stock repurchase in violation
  of Delaware corporate law. Our certificate of incorporation provides that no director shall be personally liable to us or our stockholders
  for monetary damages for any breach of fiduciary duty as a director, notwithstanding any provision of law imposing such liability, except
  to the extent that the DGCL prohibits the elimination or limitation of liability of directors for breaches of fiduciary duty.</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">Section 145 of the DGCL provides that a corporation
  has the power to indemnify a director, officer, employee, or agent of the corporation, or a person serving at the request of the corporation
  for another corporation, partnership, joint venture, trust or other enterprise in related capacities against expenses (including attorneys&rsquo;
  fees), judgments, fines and amounts paid in settlement actually and reasonably incurred by the person in connection with an action, suit
  or proceeding to which he was or is a party or is threatened to be made a party to any threatened, ending or completed action, suit or
  proceeding by reason of such position, if such person acted in good faith and in a manner he reasonably believed to be in or not opposed
  to the best interests of the corporation, and, in any criminal action or proceeding, had no reasonable cause to believe his conduct was
  unlawful, except that, in the case of actions brought by or in the right of the corporation, no indemnification shall be made with respect
  to any claim, issue or matter as to which such person shall have been adjudged to be liable to the corporation unless and only to the
  extent that the Court of Chancery or other adjudicating court determines that, despite the adjudication of liability but in view of all
  of the circumstances of the case, such person is fairly and reasonably entitled to indemnity for such expenses which the Court of Chancery
  or such other court shall deem proper.</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">Our certificate of incorporation provides that
  we will indemnify each person who was or is a party or threatened to be made a party to any threatened, pending or completed action, suit
  or proceeding (other than an action by or in the right of us) by reason of the fact that he or she is or was, or has agreed to become,
  a director or officer, or is or was serving, or has agreed to serve, at our request as a director, officer, partner, employee or trustee
  of, or in a similar capacity with, another corporation, partnership, joint venture, trust or other enterprise (all such persons being
  referred to as an &ldquo;Indemnitee&rdquo;), or by reason of any action alleged to have been taken or omitted in such capacity, against
  all expenses (including attorneys&rsquo; fees), judgments, fines and amounts paid in settlement actually and reasonably incurred in connection
  with such action, suit or proceeding and any appeal therefrom, if such Indemnitee acted in good faith and in a manner he or she reasonably
  believed to be in, or not opposed to, our best interests, and, with respect to any criminal action or proceeding, he or she had no reasonable
  cause to believe his or her conduct was unlawful. Our certificate of incorporation provides that we will indemnify any Indemnitee who
  was or is a party to an action or suit by or in the right of us to procure a judgment in our favor by reason of the fact that the Indemnitee
  is or was, or has agreed to become, a director or officer, or is or was serving, or has agreed to serve, at our request as a director,
  officer, partner, employee or trustee of, or in a similar capacity with, another corporation, partnership, joint venture, trust or other
  enterprise, or by reason of any action alleged to have been taken or omitted in such capacity, against all expenses (including attorneys&rsquo;
  fees) and, to the extent permitted by law, amounts paid in settlement actually and reasonably incurred in connection with such action,
  suit or proceeding, and any appeal therefrom, if the Indemnitee acted in good faith and in a manner he or she reasonably believed to be
  in, or not opposed to, our best interests, except that no indemnification shall be made with respect to any claim, issue or matter as
  to which such person shall have been adjudged to be liable to us, unless a court determines that, despite such adjudication but in view
  of all of the circumstances, he or she is entitled to indemnification of such expenses. Notwithstanding the foregoing, to the extent that
  any Indemnitee has been successful, on the merits or otherwise, he or she will be indemnified by us against all expenses (including attorneys&rsquo;
  fees) actually and reasonably incurred in connection therewith. Expenses must be advanced to an Indemnitee under certain circumstances.</P>
  
  <P STYLE="text-align: justify; font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">We have entered into indemnification agreements
  with each of our directors and officers. These indemnification agreements may require us, among other things, to indemnify our directors
  and officers for some expenses, including attorneys&rsquo; fees, judgments, fines and settlement amounts incurred by a director or officer
  in any action or proceeding arising out of his or her service as one of our directors or officers, or any of our subsidiaries or any other
  company or enterprise to which the person provides services at our request.</P>
  
  <P STYLE="text-align: justify; font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">We maintain a general liability insurance policy
  that covers certain liabilities of directors and officers of our corporation arising out of claims based on acts or omissions in their
  capacities as directors or officers.</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"></P>
  
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  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B>Item 8. Exhibits.</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
  
  <TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
    <TR STYLE="vertical-align: top">
      <TD STYLE="border-bottom: Black 1.5pt solid; text-align: left; width: 6%; vertical-align: bottom"><FONT STYLE="font-size: 10pt; text-decoration: none"><B>Exhibit
      Number</B></FONT></TD>
      <TD STYLE="text-align: center; padding-bottom: 1.5pt; width: 2%; vertical-align: bottom"><FONT STYLE="text-decoration: none">&nbsp;</FONT></TD>
      <TD STYLE="border-bottom: Black 1.5pt solid; vertical-align: bottom; text-align: center; width: 40%"><B>Exhibit Description</B></TD>
      <TD STYLE="text-align: center; padding-bottom: 1.5pt; width: 2%; vertical-align: bottom"><FONT STYLE="text-decoration: none">&nbsp;</FONT></TD>
      <TD STYLE="border-bottom: Black 1.5pt solid; text-align: center; width: 50%; vertical-align: bottom"><B>Method of Filing&nbsp;</B></TD></TR>
    <TR STYLE="vertical-align: top">
      <TD><FONT STYLE="text-decoration: none">&nbsp;</FONT></TD>
      <TD><FONT STYLE="text-decoration: none">&nbsp;</FONT></TD>
      <TD STYLE="text-align: justify"><FONT STYLE="text-decoration: none">&nbsp;</FONT></TD>
      <TD><FONT STYLE="text-decoration: none">&nbsp;</FONT></TD>
      <TD STYLE="text-align: justify"><FONT STYLE="font-size: 10pt; text-decoration: none"><B>&nbsp;</B></FONT></TD></TR>
    <TR STYLE="vertical-align: top; background-color: rgb(204,238,255)">
      <TD><FONT STYLE="font-size: 10pt; text-decoration: none">4.1</FONT></TD>
      <TD><FONT STYLE="text-decoration: none">&nbsp;</FONT></TD>
      <TD STYLE="text-align: justify"><FONT STYLE="font-size: 10pt; text-decoration: none"><A HREF="https://www.sec.gov/Archives/edgar/data/1721484/000121390021018716/f10k2020ex2-1_longeveron.htm" STYLE="-sec-extract: exhibit">Certificate of Incorporation of Longeveron Inc.</A></FONT></TD>
      <TD><FONT STYLE="text-decoration: none">&nbsp;</FONT></TD>
      <TD STYLE="text-align: justify"><FONT STYLE="font-size: 10pt; text-decoration: none">Incorporated by reference to Exhibit 2.1 to
      the Registrant&rsquo;s Annual Report on Form 10-K filed on March 30, 2021</FONT></TD></TR>
    <TR STYLE="vertical-align: top; background-color: White">
      <TD><FONT STYLE="font-size: 10pt; text-decoration: none">4.2</FONT></TD>
      <TD><FONT STYLE="text-decoration: none">&nbsp;</FONT></TD>
      <TD STYLE="text-align: justify"><FONT STYLE="font-size: 10pt; text-decoration: none"><A HREF="https://www.sec.gov/Archives/edgar/data/1721484/000121390021009581/ea135545ex4-2_longeveron.htm" STYLE="-sec-extract: exhibit">Bylaws of Longeveron Inc.</A></FONT></TD>
      <TD><FONT STYLE="text-decoration: none">&nbsp;</FONT></TD>
      <TD STYLE="text-align: justify"><FONT STYLE="font-size: 10pt; text-decoration: none">Incorporated by reference to Exhibit 4.2 to
      the Registrant&rsquo;s Registration Statement on Form S-8 filed on February 16, 2021</FONT></TD></TR>
    <TR STYLE="vertical-align: top; background-color: rgb(204,238,255)">
      <TD><FONT STYLE="font-size: 10pt; text-decoration: none">4.3</FONT></TD>
      <TD><FONT STYLE="text-decoration: none">&nbsp;</FONT></TD>
      <TD STYLE="text-align: justify"><FONT STYLE="font-size: 10pt; text-decoration: none"><A HREF="https://www.sec.gov/Archives/edgar/data/1721484/000121390021006475/ea134523ex4-1_longeveron.htm" STYLE="-sec-extract: exhibit">Specimen Class A Common Stock Certificate evidencing the shares of Class A common stock</A></FONT></TD>
      <TD><FONT STYLE="text-decoration: none">&nbsp;</FONT></TD>
      <TD STYLE="text-align: justify"><FONT STYLE="font-size: 10pt; text-decoration: none">Incorporated by reference to Exhibit 4.1 on
      Registrant&rsquo;s Registration Statement No. 333-252234 filed February 3, 2021</FONT></TD></TR>
    <TR STYLE="vertical-align: top; background-color: White">
      <TD><FONT STYLE="font-size: 10pt; text-decoration: none">5.1</FONT></TD>
      <TD><FONT STYLE="text-decoration: none">&nbsp;</FONT></TD>
      <TD STYLE="text-align: justify"><FONT STYLE="font-size: 10pt; text-decoration: none"><A HREF="ea180763ex5-1_longeveron.htm">Opinion of Buchanan Ingersoll &amp; Rooney PC</A></FONT></TD>
      <TD><FONT STYLE="text-decoration: none">&nbsp;</FONT></TD>
      <TD STYLE="text-align: justify"><FONT STYLE="font-size: 10pt; text-decoration: none">Filed herewith</FONT></TD></TR>
    <TR STYLE="vertical-align: top; background-color: rgb(204,238,255)">
      <TD><FONT STYLE="font-size: 10pt; text-decoration: none">23.1</FONT></TD>
      <TD><FONT STYLE="text-decoration: none">&nbsp;</FONT></TD>
      <TD STYLE="text-align: justify"><FONT STYLE="font-size: 10pt; text-decoration: none"><A HREF="ea180763ex23-1_longeveron.htm">Consent
      of Independent Registered Public Accounting Firm</A></FONT></TD>
      <TD><FONT STYLE="text-decoration: none">&nbsp;</FONT></TD>
      <TD STYLE="text-align: justify"><P STYLE="text-align: justify; font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><FONT STYLE="text-decoration: none">Filed
                                      herewith</FONT></P></TD></TR>
    <TR STYLE="vertical-align: top; background-color: White">
      <TD><FONT STYLE="font-size: 10pt; text-decoration: none">23.2</FONT></TD>
      <TD>&nbsp;</TD>
      <TD STYLE="text-align: justify"><P STYLE="margin: 0; font: 10pt Times New Roman, Times, Serif"><A HREF="ea180763ex23-2_longeveron.htm">Consent of Former Independent Registered Public Accounting Firm</A></P></TD>
      <TD>&nbsp;</TD>
      <TD STYLE="text-align: justify">Filed herewith</TD></TR>
    <TR STYLE="vertical-align: top; background-color: rgb(204,238,255)">
      <TD><FONT STYLE="font-size: 10pt; text-decoration: none">23.3</FONT></TD>
      <TD><FONT STYLE="text-decoration: none">&nbsp;</FONT></TD>
      <TD STYLE="text-align: justify"><FONT STYLE="font-size: 10pt; text-decoration: none"><A HREF="ea180763ex5-1_longeveron.htm">Consent of Buchanan Ingersoll &amp; Rooney PC (included in Exhibit&nbsp;5.1 hereto)</A></FONT></TD>
      <TD><FONT STYLE="text-decoration: none">&nbsp;</FONT></TD>
      <TD STYLE="text-align: justify"><FONT STYLE="font-size: 10pt; text-decoration: none">Included in its opinion filed as Exhibit 5.1
      hereto</FONT></TD></TR>
    <TR STYLE="vertical-align: top; background-color: White">
      <TD><FONT STYLE="font-size: 10pt; text-decoration: none">24.1</FONT></TD>
      <TD><FONT STYLE="text-decoration: none">&nbsp;</FONT></TD>
      <TD STYLE="text-align: justify"><FONT STYLE="font-size: 10pt; text-decoration: none"><A HREF="#poa_001">Power of Attorney</A></FONT></TD>
      <TD><FONT STYLE="text-decoration: none">&nbsp;</FONT></TD>
      <TD STYLE="text-align: justify"><P STYLE="text-align: justify; font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><FONT STYLE="text-decoration: none">Filed
                                      herewith</FONT></P></TD></TR>
    <TR STYLE="vertical-align: top; background-color: rgb(204,238,255)">
      <TD><FONT STYLE="font-size: 10pt; text-decoration: none">99.1</FONT></TD>
      <TD><FONT STYLE="text-decoration: none">&nbsp;</FONT></TD>
      <TD STYLE="text-align: justify"><FONT STYLE="font-size: 10pt; text-decoration: none"><A HREF="https://www.sec.gov/Archives/edgar/data/1721484/000121390023033867/def14a0423_longever.htm#T99006" STYLE="-sec-extract: exhibit">Amended and Restated Longeveron Inc. 2021 Incentive Award Plan</A></FONT></TD>
      <TD><FONT STYLE="text-decoration: none">&nbsp;</FONT></TD>
      <TD STYLE="text-align: justify"><FONT STYLE="font-size: 10pt; text-decoration: none">Incorporated by reference to Appendix A to the
      Registrant&rsquo;s Definitive Proxy Statement on Schedule 14A filed with the SEC on April 28, 2023</FONT></TD></TR>
    <TR STYLE="vertical-align: top; background-color: White">
      <TD><FONT STYLE="font-size: 10pt; text-decoration: none">107</FONT></TD>
      <TD><FONT STYLE="text-decoration: none">&nbsp;</FONT></TD>
      <TD STYLE="text-align: justify"><FONT STYLE="font-size: 10pt; text-decoration: none"><A HREF="ea180763ex-fee_longeveron.htm">Filing Fee Table</A></FONT></TD>
      <TD><FONT STYLE="text-decoration: none">&nbsp;</FONT></TD>
      <TD STYLE="text-align: justify"><FONT STYLE="font-size: 10pt; text-decoration: none">Filed herewith</FONT></TD></TR>
    </TABLE>
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; background-color: white"><B>&nbsp;</B></P>
  
  <!-- Field: Page; Sequence: 5; Value: 1 -->
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      <DIV STYLE="break-before: page; margin-top: 6pt; margin-bottom: 12pt"><P STYLE="margin: 0pt">&nbsp;</P></DIV>
      <!-- Field: /Page -->
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>Signatures</B></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>
  
  <P STYLE="text-align: justify; font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Pursuant to the requirements of the Securities Act, the registrant
  certifies that it has reasonable grounds to believe that it meets all of the requirements for filing on Form S-8 and has duly caused this
  Registration Statement to be signed on its behalf by the undersigned, thereunto duly authorized, in the City of Miami, Florida, on June 26, 2023.</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
  
  <TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
    <TR STYLE="vertical-align: bottom">
      <TD>&nbsp;</TD>
      <TD COLSPAN="2"><FONT STYLE="font-size: 10pt"><B>LONGEVERON Inc.</B></FONT></TD></TR>
    <TR STYLE="vertical-align: bottom">
      <TD>&nbsp;</TD>
      <TD COLSPAN="2">&nbsp;</TD></TR>
    <TR>
      <TD STYLE="width: 60%">&nbsp;</TD>
      <TD STYLE="vertical-align: top; width: 4%"><FONT STYLE="font-size: 10pt">By:</FONT></TD>
      <TD STYLE="vertical-align: bottom; width: 36%; border-bottom: black 1.5pt solid"><FONT STYLE="font-size: 10pt">/s/ Wa&rsquo;el Hashad</FONT></TD></TR>
    <TR STYLE="vertical-align: bottom">
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD><FONT STYLE="font-size: 10pt">Wa&rsquo;el Hashad</FONT></TD></TR>
    <TR STYLE="vertical-align: bottom">
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD><FONT STYLE="font-size: 10pt">Chief Executive Officer</FONT></TD></TR>
    </TABLE>
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><FONT STYLE="text-transform: uppercase"><B><A NAME="poa_001"></A>SIGNATURES
  AND POWER OF ATTORNEY</B></FONT></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>
  
  <P STYLE="text-align: justify; font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">We, the undersigned officers and directors of Longeveron Inc., hereby
  severally constitute and appoint Wa&rsquo;el Hashad (with full power to act alone), our true and lawful attorneys-in-fact and agent, with
  full power of substitution and resubstitution in each of them for him and in his name, place and stead, and in any and all capacities,
  to sign any and all amendments (including post-effective amendments) to this Registration Statement (or any other registration statement
  for the same offering that is to be effective upon filing pursuant to Rule 462(b) under the Securities Act of 1933), and to file the same,
  with all exhibits thereto and other documents in connection therewith, with the Securities and Exchange Commission, granting unto said
  attorneys-in-fact and agents, full power and authority to do and perform each and every act and thing requisite or necessary to be done
  in and about the premises, as full to all intents and purposes as he might or could do in person, hereby ratifying and confirming all
  that said attorneys-in-fact and agents or any of them, or their or his substitute or substitutes, may lawfully do or cause to be done
  by virtue hereof.</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
  
  <P STYLE="text-align: justify; font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Pursuant to the requirements of the Securities Act of 1933, this Registration
  Statement has been signed by the following persons in the capacities held on the dates indicated.</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
  
  <TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
    <TR STYLE="vertical-align: top">
      <TD STYLE="border-bottom: Black 1.5pt solid; text-align: center; width: 40%"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt"><B>Signature</B></FONT></TD>
      <TD STYLE="padding-bottom: 1.5pt; text-align: center; width: 2%"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">&nbsp;</FONT></TD>
      <TD STYLE="border-bottom: Black 1.5pt solid; text-align: center; width: 40%"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt"><B>Title</B></FONT></TD>
      <TD STYLE="padding-bottom: 1.5pt; text-align: center; width: 2%"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">&nbsp;</FONT></TD>
      <TD STYLE="border-bottom: Black 1.5pt solid; text-align: center; width: 16%"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt"><B>Date</B></FONT></TD></TR>
    <TR STYLE="vertical-align: top">
      <TD STYLE="text-align: center"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">&nbsp;</FONT></TD>
      <TD STYLE="text-align: center"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">&nbsp;</FONT></TD>
      <TD STYLE="text-align: center"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">&nbsp;</FONT></TD>
      <TD STYLE="text-align: center"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">&nbsp;</FONT></TD>
      <TD STYLE="text-align: center"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">&nbsp;</FONT></TD></TR>
    <TR STYLE="vertical-align: top">
      <TD STYLE="border-bottom: Black 1.5pt solid"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">/s/ Wa&rsquo;el
      Hashad</FONT></TD>
      <TD><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">&nbsp;</FONT></TD>
      <TD><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">Chief Executive Officer and Director</FONT></TD>
      <TD><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">&nbsp;</FONT></TD>
      <TD STYLE="text-align: center"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">June 26, 2023</FONT></TD></TR>
    <TR STYLE="vertical-align: top">
      <TD><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">Wa&rsquo;el Hashad</FONT></TD>
      <TD><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">&nbsp;</FONT></TD>
      <TD><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">(principal executive officer)</FONT></TD>
      <TD><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">&nbsp;</FONT></TD>
      <TD STYLE="text-align: center"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">&nbsp;</FONT></TD></TR>
    <TR STYLE="vertical-align: top">
      <TD><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">&nbsp;</FONT></TD>
      <TD><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">&nbsp;</FONT></TD>
      <TD><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">&nbsp;</FONT></TD>
      <TD><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">&nbsp;</FONT></TD>
      <TD STYLE="text-align: center"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">&nbsp;</FONT></TD></TR>
    <TR STYLE="vertical-align: top">
      <TD STYLE="border-bottom: Black 1.5pt solid"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">/s/ James
      Clavijo</FONT></TD>
      <TD><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">&nbsp;</FONT></TD>
      <TD><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">Interim Chief Financial Officer</FONT></TD>
      <TD><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">&nbsp;</FONT></TD>
      <TD STYLE="text-align: center"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">June 26, 2023</FONT></TD></TR>
    <TR STYLE="vertical-align: top">
      <TD><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">James Clavijo</FONT></TD>
      <TD><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">&nbsp;</FONT></TD>
      <TD><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">(principal financial officer and principal accounting
      officer)</FONT></TD>
      <TD><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">&nbsp;</FONT></TD>
      <TD STYLE="text-align: center"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">&nbsp;</FONT></TD></TR>
    <TR STYLE="vertical-align: top">
      <TD><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">&nbsp;</FONT></TD>
      <TD><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">&nbsp;</FONT></TD>
      <TD><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">&nbsp;</FONT></TD>
      <TD><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">&nbsp;</FONT></TD>
      <TD STYLE="text-align: center"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">&nbsp;</FONT></TD></TR>
    <TR STYLE="vertical-align: top">
      <TD STYLE="border-bottom: Black 1.5pt solid"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">/s/ Joshua
      M. Hare</FONT></TD>
      <TD><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">&nbsp;</FONT></TD>
      <TD><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">Director</FONT></TD>
      <TD><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">&nbsp;</FONT></TD>
      <TD STYLE="text-align: center"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">June 26, 2023&nbsp;</FONT></TD></TR>
    <TR STYLE="vertical-align: top">
      <TD><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">Joshua M. Hare</FONT></TD>
      <TD><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">&nbsp;</FONT></TD>
      <TD><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">&nbsp;</FONT></TD>
      <TD><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">&nbsp;</FONT></TD>
      <TD STYLE="text-align: center"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">&nbsp;</FONT></TD></TR>
    <TR STYLE="vertical-align: top">
      <TD><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">&nbsp;</FONT></TD>
      <TD><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">&nbsp;</FONT></TD>
      <TD><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">&nbsp;</FONT></TD>
      <TD><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">&nbsp;</FONT></TD>
      <TD STYLE="text-align: center"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">&nbsp;</FONT></TD></TR>
    <TR STYLE="vertical-align: top">
      <TD STYLE="border-bottom: Black 1.5pt solid"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">/s/ Neil E.
      Hare</FONT></TD>
      <TD><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">&nbsp;</FONT></TD>
      <TD><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">Director</FONT></TD>
      <TD><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">&nbsp;</FONT></TD>
      <TD STYLE="text-align: center"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">June 26, 2023</FONT></TD></TR>
    <TR STYLE="vertical-align: top">
      <TD><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">Neil E. Hare</FONT></TD>
      <TD><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">&nbsp;</FONT></TD>
      <TD><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">&nbsp;</FONT></TD>
      <TD><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">&nbsp;</FONT></TD>
      <TD STYLE="text-align: center"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">&nbsp;</FONT></TD></TR>
    <TR STYLE="vertical-align: top">
      <TD><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">&nbsp;</FONT></TD>
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      <TD STYLE="text-align: center"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">&nbsp;</FONT></TD></TR>
    <TR STYLE="vertical-align: top">
      <TD STYLE="border-bottom: Black 1.5pt solid"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">/s/ Rock Soffer</FONT></TD>
      <TD><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">&nbsp;</FONT></TD>
      <TD><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">Director</FONT></TD>
      <TD><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">&nbsp;</FONT></TD>
      <TD STYLE="text-align: center"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">June 26, 2023</FONT></TD></TR>
    <TR STYLE="vertical-align: top">
      <TD><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">Rock Soffer</FONT></TD>
      <TD><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">&nbsp;</FONT></TD>
      <TD><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">&nbsp;</FONT></TD>
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      <TD STYLE="text-align: center"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">&nbsp;</FONT></TD></TR>
    <TR STYLE="vertical-align: top">
      <TD STYLE="border-bottom: Black 1.5pt solid"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">/s/ Douglas
      Losordo</FONT></TD>
      <TD><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">&nbsp;</FONT></TD>
      <TD><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">Director</FONT></TD>
      <TD><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">&nbsp;</FONT></TD>
      <TD STYLE="text-align: center"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">June 26, 2023</FONT></TD></TR>
    <TR STYLE="vertical-align: top">
      <TD><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">Douglas Losordo</FONT></TD>
      <TD><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">&nbsp;</FONT></TD>
      <TD><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">&nbsp;</FONT></TD>
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      <TD><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">&nbsp;</FONT></TD>
      <TD><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">Director</FONT></TD>
      <TD><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">&nbsp;</FONT></TD>
      <TD STYLE="text-align: center"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">June &#8239;&#8239;&#8239;&#8239;&#8239;, 2023</FONT></TD></TR>
    <TR STYLE="vertical-align: top">
      <TD><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">Khoso Baluch</FONT></TD>
      <TD><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">&nbsp;</FONT></TD>
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    <TR STYLE="vertical-align: top">
      <TD STYLE="border-bottom: Black 1.5pt solid"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">/s/ Cathy
      Ross</FONT></TD>
      <TD><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">&nbsp;</FONT></TD>
      <TD><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">Director</FONT></TD>
      <TD><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">&nbsp;</FONT></TD>
      <TD STYLE="text-align: center"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">June 26, 2023</FONT></TD></TR>
    <TR STYLE="vertical-align: top">
      <TD><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">Cathy Ross</FONT></TD>
      <TD><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">&nbsp;</FONT></TD>
      <TD><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">&nbsp;</FONT></TD>
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      <TD STYLE="text-align: center"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">&nbsp;</FONT></TD></TR>
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      <TD STYLE="border-bottom: Black 1.5pt solid"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">/s/ Ursula
      Ungaro</FONT></TD>
      <TD><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">&nbsp;</FONT></TD>
      <TD><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">Director &nbsp;&nbsp; &nbsp;</FONT></TD>
      <TD><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">&nbsp;</FONT></TD>
      <TD STYLE="text-align: center"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">June 26, 2023</FONT></TD></TR>
    <TR STYLE="vertical-align: top">
      <TD><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">Ursula Ungaro</FONT></TD>
      <TD><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">&nbsp;</FONT></TD>
      <TD><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">&nbsp;</FONT></TD>
      <TD><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">&nbsp;</FONT></TD>
      <TD STYLE="text-align: center"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">&nbsp;</FONT></TD></TR>
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      <TD><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">&nbsp;</FONT></TD>
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      <TD STYLE="text-align: center"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">&nbsp;</FONT></TD></TR>
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      <TD><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">&nbsp;</FONT></TD>
      <TD><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">Director &nbsp;&nbsp; &nbsp;</FONT></TD>
      <TD><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">&nbsp;</FONT></TD>
      <TD STYLE="text-align: center"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">June &#8239;&#8239;&#8239;&#8239;&#8239;, 2023</FONT></TD></TR>
    <TR STYLE="vertical-align: top">
      <TD><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">Jeffrey Pfeffer</FONT></TD>
      <TD><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">&nbsp;</FONT></TD>
      <TD><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">&nbsp;</FONT></TD>
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metadata_documents: [{"type": "S-8", "sequence": "1", "filename": "ea180763-s8_longeveron.htm", "description": "REGISTRATION STATEMENT", "secsgml_size_bytes": 59791}]
metadata_filer: {"company-data": {"conformed-name": "Longeveron Inc.", "cik": "0001721484", "assigned-sic": "2834", "irs-number": "472174146", "state-of-incorporation": "DE", "fiscal-year-end": "1231"}, "filing-values": {"form-type": "S-8", "act": "33", "file-number": "333-272938", "film-number": "231042840"}, "business-address": {"street1": "1951 NW 7TH AVENUE", "street2": "SUITE 520", "city": "MIAMI", "state": "FL", "zip": "33136", "phone": "305-302-7158"}, "mail-address": {"street1": "1951 NW 7TH AVENUE", "street2": "SUITE 520", "city": "MIAMI", "state": "FL", "zip": "33136"}, "former-company": {"former-conformed-name": "LONGEVERON LLC", "date-changed": "20171101"}}
text: As filed with the Securities and Exchange Commission
  on June 26, 2023
  Registration No. 333-
  UNITED STATES
  SECURITIES AND EXCHANGE COMMISSION
  Washington, D.C. 20549
  FORM S-8
  REGISTRATION STATEMENT
  UNDER
  THE SECURITIES ACT OF 1933
  LONGEVERON INC.
  (Exact name of registrant as specified in its
  charter)
  Delaware
  47-2174146
  (State or other jurisdiction of
  incorporation or organization)
  (I.R.S. employer
  identification number)
  1951 NW 7
  th
  Avenue, Suite 520
  Miami, Florida 33136
  Telephone: (305) 909-0840
  (Address, including zip code, and telephone number,
  including area code, of registrant's principal executive offices)
  Amended and Restated Longeveron Inc. 2021 Incentive
  Award Plan
  (Full title of the Plan)
  Wa'el Hashad
  Chief Executive Officer
  Longeveron Inc.
  1951 NW 7
  th
  Ave., Suite 520
  Miami, FL 33136
  (305) 909-0840
  (Name, address, including zip code, and telephone
  number, including area code, of agent for service)
  Copies to:
  Jennifer Minter, Esq.
  Adam G. Wicks, Esq.
  Buchanan Ingersoll & Rooney PC
  Union Trust Building
  501 Grant Street, Suite 200
  Pittsburgh, PA 15219
  (412) 562-8800
  Indicate by check mark whether the registrant is a large accelerated
  filer, an accelerated filer, a nonaccelerated filer, smaller reporting company, or an emerging growth company. See the definitions of
  "large accelerated filer," "accelerated filer," "smaller reporting company," and "emerging growth
  company" in Rule 12b-2 of the Exchange Act.
  Large Accelerated Filer
  ☐
  Accelerated filer
  ☐
  Non-accelerated filer
  ☒
  Smaller reporting company
  ☒
  Emerging growth company
  ☒
  If an emerging growth company, indicate by check mark if the registrant
  has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant
  to Section 7(a)(2)(B) of the Securities Act.
  ☐
  EXPLANATORY NOTE
  Longeveron Inc. (referred to as the "Registrant,"
  "the Company," "we," "us" or "our" unless specified otherwise) is filing this registration
  statement on Form S-8 (the "Registration Statement") for the purpose of registering an additional 1,500,000 shares of our
  Class A Common Stock, par value $0.001 per share, for issuance under the Amended and Restated Longeveron Inc. 2021 Incentive Award Plan
  (the "Plan"). The 1,500,000 shares of Class A Common Stock being registered pursuant to this Registration Statement are in
  addition to the 2,074,402 shares of Class A Common Stock under the Plan currently registered on our Registration Statement on Form S-8
  filed on February 16, 2021, file number 333-253141 (the "2021 Registration Statement"). This Registration Statement relates
  to the same class of securities to which the 2021 Registration Statement relates and is submitted pursuant to General Instruction E to
  Form S-8. Pursuant to General Instruction E, this Registration Statement incorporates by reference the contents of the 2021 Registration
  Statement.
  PART II
  INFORMATION REQUIRED IN THE REGISTRATION STATEMENT
  Item 3. Incorporation of Documents by Reference.
  In
  addition to the 2021 Registration Statement, the following documents, which have been heretofore filed by the Company with the SEC pursuant
  to the Securities Exchange Act of 1934 (the "Exchange Act"), other than any portions of the respective filings that were furnished,
  rather than filed, pursuant to Item 2.02 or Item 7.01 of Current Reports on Form 8-K (including exhibits related thereto) or other applicable
  SEC rules, shall be deemed incorporated by reference herein and to be a part of this Registration Statement from the date of filing of
  such documents:
  (a)
  Our Annual Report on
  Form 10-K
  for the fiscal year ended December 31, 2022 filed with the SEC on March 14, 2023;
  (b)
  All other reports filed by
  us pursuant to Section 13(a) or 15(d) of the Exchange Act since December 31, 2022 (in each case, except for the information furnished
  under Items 2.02 or 7.01 in any current report on Form 8-K); and
  (c)
  The description of the Registrant's
  common stock set forth in the Registrant's registration statement on
  Form 8-A
  (File No. 001-40060), filed by
  the Registrant with the SEC under Section 12(b) of the Exchange Act on February 11, 2021, including
  Exhibit 4.2
  to the
  Annual Report on Form 10-K for the fiscal year ended December 31, 2022 filed with the SEC on March 14, 2023 and any other
  amendments or reports filed for the purpose of updating such description.
  In addition, all documents
  filed by the Registrant pursuant to Section 13(a), 13(c), 14 or 15(d) of the Exchange Act subsequent to the filing of this Registration
  Statement and prior to the filing of a post-effective amendment which indicates that all securities offered hereby have been sold or which
  de-registers all securities then remaining unsold shall be deemed to be incorporated by reference into this Registration Statement and
  to be a part hereof from the date of filing such documents, except as to specific sections of such statements as set forth therein. Any
  statement contained in a document incorporated or deemed to be incorporated by reference herein shall be deemed to be modified or superseded
  for purposes of this Registration Statement to the extent that a statement contained herein or in any other subsequently filed document
  which also is incorporated or deemed to be incorporated by reference herein modifies or supersedes such statement. Any statement contained
  herein shall be deemed to be modified or superseded for purposes of this Registration Statement to the extent that a statement contained
  in any subsequently filed document which also is incorporated or deemed to be incorporated by reference herein modifies or supersedes
  such statement. Any such statement so modified or superseded shall not be deemed, except as so modified or superseded, to constitute a
  part of this Registration Statement.
  Under no circumstances
  shall any information furnished under Item 2.02 or 7.01 of Form 8-K be deemed incorporated herein by reference unless such Form 8-K
  expressly provides to the contrary.
  Item 5. Interests of Named Experts and Counsel.
  The validity of the securities registered hereby has
  been passed upon for the Company by Buchanan Ingersoll & Rooney PC ("Buchanan"), Pittsburgh, Pennsylvania. Certain
  attorneys affiliated with Buchanan beneficially own an aggregate of 20,000 shares of our Class A Common Stock.
  II-
  1
  Item 6. Indemnification of Directors and Officers.
  Section 102 of the Delaware General Corporation
  Law ("DGCL") permits a corporation to eliminate the personal liability of directors and officers of a corporation to the corporation
  or its stockholders for monetary damages for a breach of fiduciary duty as a director or officer, except where the director or officer
  breached his duty of loyalty, failed to act in good faith, engaged in intentional misconduct or knowingly violated a law, or obtained
  an improper personal benefit, or in the case of directors authorized the payment of a dividend or approved a stock repurchase in violation
  of Delaware corporate law. Our certificate of incorporation provides that no director shall be personally liable to us or our stockholders
  for monetary damages for any breach of fiduciary duty as a director, notwithstanding any provision of law imposing such liability, except
  to the extent that the DGCL prohibits the elimination or limitation of liability of directors for breaches of fiduciary duty.
  Section 145 of the DGCL provides that a corporation
  has the power to indemnify a director, officer, employee, or agent of the corporation, or a person serving at the request of the corporation
  for another corporation, partnership, joint venture, trust or other enterprise in related capacities against expenses (including attorneys'
  fees), judgments, fines and amounts paid in settlement actually and reasonably incurred by the person in connection with an action, suit
  or proceeding to which he was or is a party or is threatened to be made a party to any threatened, ending or completed action, suit or
  proceeding by reason of such position, if such person acted in good faith and in a manner he reasonably believed to be in or not opposed
  to the best interests of the corporation, and, in any criminal action or proceeding, had no reasonable cause to believe his conduct was
  unlawful, except that, in the case of actions brought by or in the right of the corporation, no indemnification shall be made with respect
  to any claim, issue or matter as to which such person shall have been adjudged to be liable to the corporation unless and only to the
  extent that the Court of Chancery or other adjudicating court determines that, despite the adjudication of liability but in view of all
  of the circumstances of the case, such person is fairly and reasonably entitled to indemnity for such expenses which the Court of Chancery
  or such other court shall deem proper.
  Our certificate of incorporation provides that
  we will indemnify each person who was or is a party or threatened to be made a party to any threatened, pending or completed action, suit
  or proceeding (other than an action by or in the right of us) by reason of the fact that he or she is or was, or has agreed to become,
  a director or officer, or is or was serving, or has agreed to serve, at our request as a director, officer, partner, employee or trustee
  of, or in a similar capacity with, another corporation, partnership, joint venture, trust or other enterprise (all such persons being
  referred to as an "Indemnitee"), or by reason of any action alleged to have been taken or omitted in such capacity, against
  all expenses (including attorneys' fees), judgments, fines and amounts paid in settlement actually and reasonably incurred in connection
  with such action, suit or proceeding and any appeal therefrom, if such Indemnitee acted in good faith and in a manner he or she reasonably
  believed to be in, or not opposed to, our best interests, and, with respect to any criminal action or proceeding, he or she had no reasonable
  cause to believe his or her conduct was unlawful. Our certificate of incorporation provides that we will indemnify any Indemnitee who
  was or is a party to an action or suit by or in the right of us to procure a judgment in our favor by reason of the fact that the Indemnitee
  is or was, or has agreed to become, a director or officer, or is or was serving, or has agreed to serve, at our request as a director,
  officer, partner, employee or trustee of, or in a similar capacity with, another corporation, partnership, joint venture, trust or other
  enterprise, or by reason of any action alleged to have been taken or omitted in such capacity, against all expenses (including attorneys'
  fees) and, to the extent permitted by law, amounts paid in settlement actually and reasonably incurred in connection with such action,
  suit or proceeding, and any appeal therefrom, if the Indemnitee acted in good faith and in a manner he or she reasonably believed to be
  in, or not opposed to, our best interests, except that no indemnification shall be made with respect to any claim, issue or matter as
  to which such person shall have been adjudged to be liable to us, unless a court determines that, despite such adjudication but in view
  of all of the circumstances, he or she is entitled to indemnification of such expenses. Notwithstanding the foregoing, to the extent that
  any Indemnitee has been successful, on the merits or otherwise, he or she will be indemnified by us against all expenses (including attorneys'
  fees) actually and reasonably incurred in connection therewith. Expenses must be advanced to an Indemnitee under certain circumstances.
  We have entered into indemnification agreements
  with each of our directors and officers. These indemnification agreements may require us, among other things, to indemnify our directors
  and officers for some expenses, including attorneys' fees, judgments, fines and settlement amounts incurred by a director or officer
  in any action or proceeding arising out of his or her service as one of our directors or officers, or any of our subsidiaries or any other
  company or enterprise to which the person provides services at our request.
  We maintain a general liability insurance policy
  that covers certain liabilities of directors and officers of our corporation arising out of claims based on acts or omissions in their
  capacities as directors or officers.
  II-
  2
  Item 8. Exhibits.
  Exhibit
      Number
  Exhibit Description
  Method of Filing
  4.1
  Certificate of Incorporation of Longeveron Inc.
  Incorporated by reference to Exhibit 2.1 to
      the Registrant's Annual Report on Form 10-K filed on March 30, 2021
  4.2
  Bylaws of Longeveron Inc.
  Incorporated by reference to Exhibit 4.2 to
      the Registrant's Registration Statement on Form S-8 filed on February 16, 2021
  4.3
  Specimen Class A Common Stock Certificate evidencing the shares of Class A common stock
  Incorporated by reference to Exhibit 4.1 on
      Registrant's Registration Statement No. 333-252234 filed February 3, 2021
  5.1
  Opinion of Buchanan Ingersoll & Rooney PC
  Filed herewith
  23.1
  Consent
      of Independent Registered Public Accounting Firm
  Filed
                                      herewith
  23.2
  Consent of Former Independent Registered Public Accounting Firm
  Filed herewith
  23.3
  Consent of Buchanan Ingersoll & Rooney PC (included in Exhibit 5.1 hereto)
  Included in its opinion filed as Exhibit 5.1
      hereto
  24.1
  Power of Attorney
  Filed
                                      herewith
  99.1
  Amended and Restated Longeveron Inc. 2021 Incentive Award Plan
  Incorporated by reference to Appendix A to the
      Registrant's Definitive Proxy Statement on Schedule 14A filed with the SEC on April 28, 2023
  107
  Filing Fee Table
  Filed herewith
  II-
  3
  Signatures
  Pursuant to the requirements of the Securities Act, the registrant
  certifies that it has reasonable grounds to believe that it meets all of the requirements for filing on Form S-8 and has duly caused this
  Registration Statement to be signed on its behalf by the undersigned, thereunto duly authorized, in the City of Miami, Florida, on June 26, 2023.
  LONGEVERON Inc.
  By:
  /s/ Wa'el Hashad
  Wa'el Hashad
  Chief Executive Officer
  SIGNATURES
  AND POWER OF ATTORNEY
  We, the undersigned officers and directors of Longeveron Inc., hereby
  severally constitute and appoint Wa'el Hashad (with full power to act alone), our true and lawful attorneys-in-fact and agent, with
  full power of substitution and resubstitution in each of them for him and in his name, place and stead, and in any and all capacities,
  to sign any and all amendments (including post-effective amendments) to this Registration Statement (or any other registration statement
  for the same offering that is to be effective upon filing pursuant to Rule 462(b) under the Securities Act of 1933), and to file the same,
  with all exhibits thereto and other documents in connection therewith, with the Securities and Exchange Commission, granting unto said
  attorneys-in-fact and agents, full power and authority to do and perform each and every act and thing requisite or necessary to be done
  in and about the premises, as full to all intents and purposes as he might or could do in person, hereby ratifying and confirming all
  that said attorneys-in-fact and agents or any of them, or their or his substitute or substitutes, may lawfully do or cause to be done
  by virtue hereof.
  Pursuant to the requirements of the Securities Act of 1933, this Registration
  Statement has been signed by the following persons in the capacities held on the dates indicated.
  Signature
  Title
  Date
  /s/ Wa'el
      Hashad
  Chief Executive Officer and Director
  June 26, 2023
  Wa'el Hashad
  (principal executive officer)
  /s/ James
      Clavijo
  Interim Chief Financial Officer
  June 26, 2023
  James Clavijo
  (principal financial officer and principal accounting
      officer)
  /s/ Joshua
      M. Hare
  Director
  June 26, 2023
  Joshua M. Hare
  /s/ Neil E.
      Hare
  Director
  June 26, 2023
  Neil E. Hare
  /s/ Rock Soffer
  Director
  June 26, 2023
  Rock Soffer
  /s/ Douglas
      Losordo
  Director
  June 26, 2023
  Douglas Losordo
  Director
  June      , 2023
  Khoso Baluch
  /s/ Cathy
      Ross
  Director
  June 26, 2023
  Cathy Ross
  /s/ Ursula
      Ungaro
  Director
  June 26, 2023
  Ursula Ungaro
  Director
  June      , 2023
  Jeffrey Pfeffer
  II-4