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  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center"><FONT STYLE="font-family: Times New Roman, Times, Serif"><B>As
  filed with the Securities and Exchange Commission on August 14, 2020</B></FONT></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: right"><FONT STYLE="font-family: Times New Roman, Times, Serif"><B>Registration
  No. 333-&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</B></FONT></P>
  
  <!-- Field: Rule-Page --><DIV STYLE="margin-top: 0; margin-bottom: 0; width: 100%"><DIV STYLE="font-size: 1pt; border-top: Black 2pt solid; border-bottom: Black 1pt solid"><FONT STYLE="font-family: Times New Roman, Times, Serif">&nbsp;</FONT></DIV></DIV><!-- Field: /Rule-Page -->
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: right"></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0"><FONT STYLE="font-family: Times New Roman, Times, Serif">&nbsp;</FONT></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center"><FONT STYLE="font-family: Times New Roman, Times, Serif"><B>UNITED
  STATES</B></FONT></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center"><FONT STYLE="font-family: Times New Roman, Times, Serif"><B>SECURITIES
  AND EXCHANGE COMMISSION</B></FONT></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center"><FONT STYLE="font-family: Times New Roman, Times, Serif"><B>Washington,
  D.C. 20549</B></FONT></P>
  
  <P STYLE="text-align: center; font: 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 0"><FONT STYLE="font-family: Times New Roman, Times, Serif">&nbsp;</FONT></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; text-align: center; margin-top: 0; margin-bottom: 0"></P>
  
  <!-- Field: Rule-Page --><DIV STYLE="margin: 0 auto; width: 25%"><DIV STYLE="font-size: 1pt; border-top: Black 1.5pt solid"><FONT STYLE="font-family: Times New Roman, Times, Serif">&nbsp;</FONT></DIV></DIV><!-- Field: /Rule-Page -->
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; text-align: center; margin-top: 0; margin-bottom: 0"><FONT STYLE="font-family: Times New Roman, Times, Serif">&nbsp;</FONT></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center"><FONT STYLE="font-family: Times New Roman, Times, Serif"><B>FORM&nbsp;S-8</B></FONT></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0"><FONT STYLE="font-family: Times New Roman, Times, Serif">&nbsp;</FONT></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center"><FONT STYLE="font-family: Times New Roman, Times, Serif"><B>REGISTRATION
  STATEMENT</B></FONT></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center"><FONT STYLE="font-family: Times New Roman, Times, Serif"><B>UNDER</B></FONT></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center"><FONT STYLE="font-family: Times New Roman, Times, Serif"><B>THE
  SECURITIES ACT OF 1933</B></FONT></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center"><FONT STYLE="font-family: Times New Roman, Times, Serif"><B>&nbsp;</B></FONT></P>
  
  <!-- Field: Rule-Page --><DIV STYLE="margin: 0 auto; width: 25%"><DIV STYLE="font-size: 1pt; border-top: Black 1.5pt solid"><FONT STYLE="font-family: Times New Roman, Times, Serif">&nbsp;</FONT></DIV></DIV><!-- Field: /Rule-Page -->
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center"></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center"><FONT STYLE="font-family: Times New Roman, Times, Serif"><B>&nbsp;</B></FONT></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 12pt"><B>SENESTECH,
  INC.</B></FONT><B><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt"><BR>
  </FONT></B><FONT STYLE="font: 10pt Times New Roman, Times, Serif">(Exact name of registrant as specified in its charter)</FONT></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center"><FONT STYLE="font-family: Times New Roman, Times, Serif">&nbsp;</FONT></P>
  
  <TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
  <TR STYLE="font: 10pt Times New Roman, Times, Serif; vertical-align: bottom">
      <TD STYLE="border-bottom: Black 1.5pt solid; padding-top: 0; padding-right: 0; font: 10pt Times New Roman, Times, Serif; padding-left: 0; width: 49%; text-align: center; text-indent: 0"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt"><B>Delaware</B></FONT></TD>
      <TD STYLE="padding-bottom: 1.5pt; width: 2%"><FONT STYLE="font-family: Times New Roman, Times, Serif">&nbsp;</FONT></TD>
      <TD STYLE="border-bottom: Black 1.5pt solid; padding-top: 0; padding-right: 0; font: 10pt Times New Roman, Times, Serif; padding-left: 0; width: 49%; text-align: center; text-indent: 0"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt"><B>20-2079805</B></FONT></TD></TR>
  <TR STYLE="font: 10pt Times New Roman, Times, Serif; vertical-align: top">
      <TD STYLE="padding: 0; font: 10pt Times New Roman, Times, Serif; text-align: center; text-indent: 0"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">(State
      or other jurisdiction of<BR>
      incorporation or organization)</FONT></TD>
      <TD><FONT STYLE="font-family: Times New Roman, Times, Serif">&nbsp;</FONT></TD>
      <TD STYLE="padding: 0; font: 10pt Times New Roman, Times, Serif; text-align: center; text-indent: 0"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">(I.R.S.
      Employer<BR>
      Identification No.)</FONT></TD></TR>
  </TABLE>
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center"><FONT STYLE="font-family: Times New Roman, Times, Serif"><B>&nbsp;</B></FONT></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center"><FONT STYLE="font-family: Times New Roman, Times, Serif"><B>23460
  N. 19th Avenue, Suite 110<BR>
  Phoenix, AZ 85027<BR>
  (928) 779-4143<BR>
  </B>(Address of Principal Executive Offices, including zip code)</FONT></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center"><FONT STYLE="font-family: Times New Roman, Times, Serif">&nbsp;</FONT></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center"><FONT STYLE="font-family: Times New Roman, Times, Serif"><B>SENESTECH,
  INC. 2018 EQUITY INCENTIVE PLAN<BR>
  </B>(Full title of the plan)</FONT></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center"><FONT STYLE="font-family: Times New Roman, Times, Serif">&nbsp;</FONT></P>
  
  <P STYLE="text-align: center; font: 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 0"><FONT STYLE="font-family: Times New Roman, Times, Serif"><B>Kenneth
  Siegel</B></FONT></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center"><FONT STYLE="font-family: Times New Roman, Times, Serif"><B>Chief
  Executive Officer</B></FONT></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center"><FONT STYLE="font-family: Times New Roman, Times, Serif"><B>SenesTech,
  Inc.</B></FONT></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center"><FONT STYLE="font-family: Times New Roman, Times, Serif"><B>23460
  N. 19th Avenue, Suite 110<BR>
  Phoenix, AZ 85027<BR>
  (928) 779-4143</B></FONT></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center"><FONT STYLE="font-family: Times New Roman, Times, Serif">(Name,
  address, including zip code and telephone number, including area code, of agent for service)</FONT></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center"><FONT STYLE="font-family: Times New Roman, Times, Serif">&nbsp;</FONT></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center"></P>
  
  <!-- Field: Rule-Page --><DIV STYLE="margin: 0 auto; width: 25%"><DIV STYLE="font-size: 1pt; border-top: Black 1.5pt solid"><FONT STYLE="font-family: Times New Roman, Times, Serif">&nbsp;</FONT></DIV></DIV><!-- Field: /Rule-Page -->
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center"><FONT STYLE="font-family: Times New Roman, Times, Serif">&nbsp;</FONT></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 0; text-align: center"><FONT STYLE="font-family: Times New Roman, Times, Serif"><B>Copy
  to:</B>&nbsp;</FONT></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 0; text-align: center"><FONT STYLE="font-family: Times New Roman, Times, Serif"><B>Chris
  Hall<BR>
  Perkins Coie LLP<BR>
  1120 NW Couch Street, Tenth Floor</B></FONT></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 0; text-align: center"><FONT STYLE="font-family: Times New Roman, Times, Serif"><B>Portland,
  Oregon 97209-4128</B></FONT></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 0; text-align: center"><FONT STYLE="font-family: Times New Roman, Times, Serif"><B>(503)
  727-2000</B></FONT></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0"><FONT STYLE="font-family: Times New Roman, Times, Serif">&nbsp;</FONT></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0"></P>
  
  <!-- Field: Rule-Page --><DIV STYLE="margin: 0 auto; width: 25%"><DIV STYLE="font-size: 1pt; border-top: Black 1.5pt solid"><FONT STYLE="font-family: Times New Roman, Times, Serif">&nbsp;</FONT></DIV></DIV><!-- Field: /Rule-Page -->
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0"><FONT STYLE="font-family: Times New Roman, Times, Serif">&nbsp;</FONT></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0"><FONT STYLE="font-family: Times New Roman, Times, Serif">Indicate
  by check mark whether the registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, a smaller reporting
  company, or an emerging growth company. See the definitions of &ldquo;large accelerated filer,&rdquo; &ldquo;accelerated filer,&rdquo;
  &ldquo;smaller reporting company,&rdquo; and &ldquo;emerging growth company&rdquo; in Rule&nbsp;12b-2 of the Exchange Act.</FONT></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0"><FONT STYLE="font-family: Times New Roman, Times, Serif">&nbsp;</FONT></P>
  
  <TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%">
  <TR STYLE="font: 10pt Times New Roman, Times, Serif">
      <TD STYLE="padding: 0; font: 10pt Times New Roman, Times, Serif; vertical-align: bottom; width: 30%; text-indent: 0"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">Large
      accelerated filer&nbsp;&nbsp;&#9744; </FONT></TD>
      <TD STYLE="padding: 0; font: 10pt Times New Roman, Times, Serif; vertical-align: bottom; width: 2%; text-align: center; text-indent: 0"><FONT STYLE="font-family: Times New Roman, Times, Serif">&nbsp;</FONT></TD>
      <TD STYLE="padding: 0; font: 10pt Times New Roman, Times, Serif; vertical-align: top; width: 37%; text-align: center; text-indent: 0"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">Non-accelerated
      filer&nbsp;&#9746;</FONT></TD>
      <TD STYLE="padding: 0; font: 10pt Times New Roman, Times, Serif; vertical-align: bottom; width: 2%; text-align: center; text-indent: 0"><FONT STYLE="font-family: Times New Roman, Times, Serif">&nbsp;</FONT></TD>
      <TD STYLE="font: 10pt Times New Roman, Times, Serif; padding: 0; vertical-align: bottom; width: 29%; text-align: left; text-indent: 0"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">Smaller
      reporting company&nbsp;&#9746;</FONT></TD></TR>
  <TR STYLE="font: 10pt Times New Roman, Times, Serif">
      <TD STYLE="padding: 0; font: 10pt Times New Roman, Times, Serif; vertical-align: top; text-indent: 0"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">Accelerated
      filer&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&#9744;</FONT></TD>
      <TD STYLE="padding: 0; font: 10pt Times New Roman, Times, Serif; vertical-align: bottom; text-align: center; text-indent: 0"><FONT STYLE="font-family: Times New Roman, Times, Serif">&nbsp;</FONT></TD>
      <TD STYLE="padding: 0; font: 10pt Times New Roman, Times, Serif; vertical-align: top; text-align: center; text-indent: 0"><FONT STYLE="font-family: Times New Roman, Times, Serif">&nbsp;</FONT></TD>
      <TD STYLE="padding: 0; font: 10pt Times New Roman, Times, Serif; vertical-align: top; text-align: center; text-indent: 0"><FONT STYLE="font-family: Times New Roman, Times, Serif">&nbsp;</FONT></TD>
      <TD STYLE="font: 10pt Times New Roman, Times, Serif; padding: 0; vertical-align: top; text-align: left; text-indent: 0"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">Emerging
      growth company&nbsp;&#9746;</FONT></TD></TR>
  </TABLE>
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0"><FONT STYLE="font-family: Times New Roman, Times, Serif">&nbsp;</FONT></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0"><FONT STYLE="font-family: Times New Roman, Times, Serif">If an
  emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying
  with any new or revised financial accounting standards provided pursuant to Section 7(a)(2)(B) of the Securities Act. &#9746;</FONT></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0"><FONT STYLE="font-family: Times New Roman, Times, Serif">&nbsp;</FONT></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0"></P>
  
  <!-- Field: Page; Sequence: 1 -->
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  <P STYLE="text-align: center; font: 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 0">&nbsp;</P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; text-align: center; margin-top: 0; margin-bottom: 0"></P>
  
  <!-- Field: Rule-Page --><DIV STYLE="margin: 0 auto; width: 25%"><DIV STYLE="font-size: 1pt; border-top: Black 1.5pt solid">&nbsp;</DIV></DIV><!-- Field: /Rule-Page -->
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; text-align: center; margin-top: 0; margin-bottom: 0"><FONT STYLE="font-family: Times New Roman, Times, Serif">&nbsp;</FONT></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center"><FONT STYLE="font-family: Times New Roman, Times, Serif"><B>CALCULATION
  OF REGISTRATION FEE</B></FONT></P>
  
  <P STYLE="text-align: center; font: 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 0"><FONT STYLE="font-family: Times New Roman, Times, Serif">&nbsp;</FONT></P>
  
  <TABLE CELLPADDING="0" CELLSPACING="0" STYLE="border-collapse: collapse; width: 100%; font: 10pt Times New Roman, Times, Serif">
  <TR STYLE="vertical-align: bottom">
      <TD STYLE="font: bold 10pt Times New Roman, Times, Serif; border-bottom: Black 1.5pt solid"><FONT STYLE="font-family: Times New Roman, Times, Serif">Title&nbsp;of&nbsp;Securities
      to&nbsp;Be&nbsp;Registered</FONT></TD><TD STYLE="font: bold 10pt Times New Roman, Times, Serif; padding-bottom: 1.5pt"><FONT STYLE="font-family: Times New Roman, Times, Serif">&nbsp;</FONT></TD>
      <TD STYLE="font: bold 10pt Times New Roman, Times, Serif; text-align: center; border-bottom: Black 1.5pt solid"><FONT STYLE="font-family: Times New Roman, Times, Serif">Amount&nbsp;to&nbsp;Be
      Registered (1)</FONT></TD><TD STYLE="font: bold 10pt Times New Roman, Times, Serif; padding-bottom: 1.5pt"><FONT STYLE="font-family: Times New Roman, Times, Serif">&nbsp;</FONT></TD>
      <TD COLSPAN="2" STYLE="font: bold 10pt Times New Roman, Times, Serif; text-align: center; border-bottom: Black 1.5pt solid"><FONT STYLE="font-family: Times New Roman, Times, Serif">Proposed&nbsp;Maximum
      Offering&nbsp;Price&nbsp;Per Share (2)</FONT></TD><TD STYLE="padding-bottom: 1.5pt; font: bold 10pt Times New Roman, Times, Serif"><FONT STYLE="font-family: Times New Roman, Times, Serif">&nbsp;</FONT></TD><TD STYLE="font: bold 10pt Times New Roman, Times, Serif; padding-bottom: 1.5pt"><FONT STYLE="font-family: Times New Roman, Times, Serif">&nbsp;</FONT></TD>
      <TD COLSPAN="2" STYLE="font: bold 10pt Times New Roman, Times, Serif; text-align: center; border-bottom: Black 1.5pt solid"><FONT STYLE="font-family: Times New Roman, Times, Serif">Proposed&nbsp;Maximum
      Aggregate&nbsp;Offering Price (2)</FONT></TD><TD STYLE="padding-bottom: 1.5pt; font: bold 10pt Times New Roman, Times, Serif"><FONT STYLE="font-family: Times New Roman, Times, Serif">&nbsp;</FONT></TD><TD STYLE="font: bold 10pt Times New Roman, Times, Serif; padding-bottom: 1.5pt"><FONT STYLE="font-family: Times New Roman, Times, Serif">&nbsp;</FONT></TD>
      <TD COLSPAN="2" STYLE="font: bold 10pt Times New Roman, Times, Serif; text-align: center; border-bottom: Black 1.5pt solid"><FONT STYLE="font-family: Times New Roman, Times, Serif">Amount
      of Registration Fee (2)</FONT></TD><TD STYLE="padding-bottom: 1.5pt; font: bold 10pt Times New Roman, Times, Serif"><FONT STYLE="font-family: Times New Roman, Times, Serif">&nbsp;</FONT></TD></TR>
  <TR STYLE="vertical-align: bottom; background-color: rgb(204,238,255)">
      <TD STYLE="padding-left: 10pt; width: 50%; font: 10pt Times New Roman, Times, Serif; text-align: left; text-indent: -10pt"><FONT STYLE="font-family: Times New Roman, Times, Serif">Common
      Stock, $0.001 par value, under the SenesTech, Inc. 2018 Equity Incentive Plan</FONT></TD><TD STYLE="width: 1%; font: 10pt Times New Roman, Times, Serif"><FONT STYLE="font-family: Times New Roman, Times, Serif">&nbsp;</FONT></TD>
      <TD STYLE="width: 13%; font: 10pt Times New Roman, Times, Serif"><FONT STYLE="font-family: Times New Roman, Times, Serif">800,000&nbsp;shares</FONT></TD><TD STYLE="width: 1%; font: 10pt Times New Roman, Times, Serif"><FONT STYLE="font-family: Times New Roman, Times, Serif">&nbsp;</FONT></TD>
      <TD STYLE="width: 1%; font: 10pt Times New Roman, Times, Serif; text-align: left"><FONT STYLE="font-family: Times New Roman, Times, Serif">$</FONT></TD><TD STYLE="width: 9%; font: 10pt Times New Roman, Times, Serif; text-align: right"><FONT STYLE="font-family: Times New Roman, Times, Serif">2.02</FONT></TD><TD STYLE="width: 1%; font: 10pt Times New Roman, Times, Serif; text-align: left"><FONT STYLE="font-family: Times New Roman, Times, Serif">&nbsp;</FONT></TD><TD STYLE="width: 1%; font: 10pt Times New Roman, Times, Serif"><FONT STYLE="font-family: Times New Roman, Times, Serif">&nbsp;</FONT></TD>
      <TD STYLE="width: 1%; font: 10pt Times New Roman, Times, Serif; text-align: left"><FONT STYLE="font-family: Times New Roman, Times, Serif">$</FONT></TD><TD STYLE="width: 9%; font: 10pt Times New Roman, Times, Serif; text-align: right"><FONT STYLE="font-family: Times New Roman, Times, Serif">1,616,000.00</FONT></TD><TD STYLE="width: 1%; font: 10pt Times New Roman, Times, Serif; text-align: left"><FONT STYLE="font-family: Times New Roman, Times, Serif">&nbsp;</FONT></TD><TD STYLE="width: 1%; font: 10pt Times New Roman, Times, Serif"><FONT STYLE="font-family: Times New Roman, Times, Serif">&nbsp;</FONT></TD>
      <TD STYLE="width: 1%; font: 10pt Times New Roman, Times, Serif; text-align: left"><FONT STYLE="font-family: Times New Roman, Times, Serif">$</FONT></TD><TD STYLE="width: 9%; font: 10pt Times New Roman, Times, Serif; text-align: right"><FONT STYLE="font-family: Times New Roman, Times, Serif">209.76</FONT></TD><TD STYLE="width: 1%; font: 10pt Times New Roman, Times, Serif; text-align: left"><FONT STYLE="font-family: Times New Roman, Times, Serif">&nbsp;</FONT></TD></TR>
  </TABLE>
  
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; text-align: center; margin-top: 0; margin-bottom: 0"><FONT STYLE="font-family: Times New Roman, Times, Serif">&nbsp;</FONT></P>
  
  <TABLE CELLPADDING="0" CELLSPACING="0" STYLE="width: 100%; font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="font: 10pt Times New Roman, Times, Serif; vertical-align: top">
  <TD STYLE="padding: 0; font: 10pt Times New Roman, Times, Serif; width: 0.25in; text-indent: 0"><FONT STYLE="font-family: Times New Roman, Times, Serif">(1)</FONT></TD><TD STYLE="padding: 0; font: 10pt Times New Roman, Times, Serif; text-indent: 0"><FONT STYLE="font-family: Times New Roman, Times, Serif">Pursuant
                                           to Rule 416(c) under the Securities Act, includes an indeterminate number of additional
                                           shares which may be necessary to adjust the number of shares issued pursuant to the plan
                                           as the result of any future stock split, stock dividend or similar adjustment of our
                                           outstanding common stock.</FONT></TD></TR></TABLE>
  
  <P STYLE="margin-right: 0; font: 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 0"><FONT STYLE="font-family: Times New Roman, Times, Serif">&nbsp;</FONT></P>
  
  <TABLE CELLPADDING="0" CELLSPACING="0" STYLE="width: 100%; font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="font: 10pt Times New Roman, Times, Serif; vertical-align: top">
  <TD STYLE="padding: 0; font: 10pt Times New Roman, Times, Serif; width: 0.25in; text-indent: 0"><FONT STYLE="font-family: Times New Roman, Times, Serif">(2)</FONT></TD><TD STYLE="padding: 0; font: 10pt Times New Roman, Times, Serif; text-indent: 0"><FONT STYLE="font-family: Times New Roman, Times, Serif">Estimated
                                           solely for the purpose of calculating the registration fee pursuant to Rule 457 under
                                           the Securities Act of 1933, as amended. The Proposed Maximum Offering Price Per Share
                                           is estimated to be $2.02 based on the average of the high sale price ($2.11) and the
                                           low sale price ($1.92) for our common stock as reported by the Nasdaq Stock Market on
                                           August 11, 2020.</FONT></TD></TR></TABLE>
  
  <P STYLE="margin-right: 0; font: 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 0"><FONT STYLE="font-family: Times New Roman, Times, Serif">&nbsp;</FONT></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0"></P>
  
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  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0"><FONT STYLE="font-family: Times New Roman, Times, Serif"><B>&nbsp;</B></FONT></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0"></P>
  
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  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0"><FONT STYLE="font-family: Times New Roman, Times, Serif"><B>&nbsp;</B></FONT></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 0; text-align: center"><FONT STYLE="font-family: Times New Roman, Times, Serif"><B>PART&nbsp;II</B></FONT></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 0; text-align: center"><FONT STYLE="font-family: Times New Roman, Times, Serif">&nbsp;</FONT></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 0; text-align: center"><FONT STYLE="font-family: Times New Roman, Times, Serif"><B>INFORMATION
  REQUIRED IN REGISTRATION STATEMENT</B></FONT></P>
  
  <P STYLE="text-align: center; font: 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 0"><FONT STYLE="font-family: Times New Roman, Times, Serif">&nbsp;</FONT></P>
  
  <TABLE CELLPADDING="0" CELLSPACING="0" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 0; width: 100%"><TR STYLE="vertical-align: top; text-align: justify">
  <TD STYLE="padding: 0; width: 8%; text-align: left; text-indent: 0"><FONT STYLE="font-family: Times New Roman, Times, Serif"><B>Item
  3.</B></FONT></TD><TD STYLE="padding: 0; text-align: justify; text-indent: 0"><FONT STYLE="font-family: Times New Roman, Times, Serif"><B>INCORPORATION
                                           OF CERTAIN DOCUMENTS BY REFERENCE</B></FONT></TD>
  </TR></TABLE>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0"><FONT STYLE="font-family: Times New Roman, Times, Serif">&nbsp;</FONT></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-indent: 38.9pt"><FONT STYLE="font-family: Times New Roman, Times, Serif">The
  following documents filed by SenesTech, Inc. (the &ldquo;<U>Registrant</U>&rdquo;) with the Securities and Exchange Commission
  (the &ldquo;<U>Commission</U>&rdquo;) are hereby incorporated by reference into this Registration Statement:</FONT></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-indent: 0.5in"><FONT STYLE="font-family: Times New Roman, Times, Serif">&nbsp;</FONT></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-indent: 38.9pt"><FONT STYLE="font-family: Times New Roman, Times, Serif">(a)&#9;The
  Registrant&rsquo;s Annual Report on <A HREF="http://www.sec.gov/Archives/edgar/data/1680378/000121390020006565/f10k2019_senestechinc.htm">Form 10-K</A> for the year ended December 31, 2019, filed with the Commission on March 17,
  2020, as amended by <A HREF="http://www.sec.gov/Archives/edgar/data/1680378/000121390020009645/f10k2019a1_senestech.htm">Form 10-K/A</A>, filed with the Commission on April 21, 2020;</FONT></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-indent: 38.9pt"><FONT STYLE="font-family: Times New Roman, Times, Serif">&nbsp;</FONT></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-indent: 38.9pt"><FONT STYLE="font-family: Times New Roman, Times, Serif">(b)&#9;The
  Registrant&rsquo;s Quarterly Reports on Form 10-Q for the quarter ended <A HREF="http://www.sec.gov/Archives/edgar/data/1680378/000121390020012605/f10q0320_senestechinc.htm">March 31, 2020</A>, filed with the Commission on May 15,
  2020, and for the quarter ended <A HREF="http://www.sec.gov/Archives/edgar/data/1680378/000121390020021758/f10q0620_senestechinc.htm">June 30, 2020</A>, filed with the Commission on August 13, 2020;</FONT></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-indent: 38.9pt"><FONT STYLE="font-family: Times New Roman, Times, Serif">&nbsp;</FONT></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-indent: 38.9pt"><FONT STYLE="font-family: Times New Roman, Times, Serif">(c)
  The Registrant&rsquo;s Current Reports on Form 8-K, filed with the Commission on <A HREF="http://www.sec.gov/Archives/edgar/data/1680378/000121390020002007/f8k012320_senestechinc.htm">January
  28, 2020</A>, <A HREF="http://www.sec.gov/Archives/edgar/data/1680378/000121390020002515/f8k013120_senestechinc.htm">February
  4, 2020</A>, <A HREF="http://www.sec.gov/Archives/edgar/data/1680378/000121390020004410/f8k022020_senestech.htm">February 20,
  2020</A>, <A HREF="https://www.sec.gov/Archives/edgar/data/1680378/000121390020005632/ea119372-8k_senestechinc.htm" STYLE="-sec-extract: exhibit">March 6, 2020</A>, <A HREF="http://www.sec.gov/Archives/edgar/data/1680378/000121390020009687/ea120880-8k_senestech.htm">April 21, 2020</A>, <A HREF="http://www.sec.gov/Archives/edgar/data/1680378/000121390020009713/ea120909-8k_senestech.htm">April 21, 2020</A>, <A HREF="http://www.sec.gov/Archives/edgar/data/1680378/000121390020009784/ea120933-8k_sensetech.htm">April
  22, 2020</A>, <A HREF="http://www.sec.gov/Archives/edgar/data/1680378/000121390020010063/ea121017-8k_sensetech.htm">April 24,
  2020</A> and <A HREF="http://www.sec.gov/Archives/edgar/data/1680378/000121390020017212/ea124047-8k_senestech.htm">July 10,
  2020</A> and the Registrant&rsquo;s Current Report on Form 8-K/A filed with the Commission on <A HREF="http://www.sec.gov/Archives/edgar/data/1680378/000121390020017455/ea124177-8ka_senestechinc.htm">July
  14, 2020 </A>(excluding any reports, or portions thereof, deemed to have been furnished under Item 2.02 or Item 7.01 and any
  exhibits included with such Items); and</FONT></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-indent: 38.9pt"><FONT STYLE="font-family: Times New Roman, Times, Serif">&nbsp;</FONT></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-indent: 38.9pt"><FONT STYLE="font-family: Times New Roman, Times, Serif">(d)
  The description of the Registrant&rsquo;s common stock contained in the Registration Statement on <A HREF="http://www.sec.gov/Archives/edgar/data/1680378/000114420416132137/v452318_8a12b.htm">Form 8-A</A> (File No. 001-37941)
  filed with the Commission on November 7, 2016 under the Securities Exchange Act of 1934, as amended (the &ldquo;<U>Exchange Act</U>&rdquo;),
  including any amendment or report filed for the purpose of updating such description.</FONT></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-indent: 0.5in"><FONT STYLE="font-family: Times New Roman, Times, Serif">&nbsp;</FONT></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-indent: 0.5in"><FONT STYLE="font-family: Times New Roman, Times, Serif">All
  documents the Registrant files pursuant to Sections 13(a), 13(c), 14 and 15(d)&nbsp;of the Exchange Act after the date hereof
  (excluding any documents or portions of such documents that are furnished under Item 2.02 or Item 7.01 of a current report on
  Form 8-K and any exhibits included with such Items), and prior to the filing of a post-effective amendment which indicates that
  the securities offered hereby have been sold or which deregisters all securities covered hereby then remaining unsold, shall also
  be deemed to be incorporated by reference into this Registration Statement and to be a part hereof commencing on the respective
  dates on which such documents are filed.</FONT></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0"><FONT STYLE="font-family: Times New Roman, Times, Serif"><B>&nbsp;</B></FONT></P>
  
  <TABLE CELLPADDING="0" CELLSPACING="0" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 0; width: 100%"><TR STYLE="font: 10pt Times New Roman, Times, Serif; vertical-align: top">
  <TD STYLE="padding: 0; font: 10pt Times New Roman, Times, Serif; width: 8%; text-indent: 0"><FONT STYLE="font-family: Times New Roman, Times, Serif"><B>Item
  4.</B></FONT></TD><TD STYLE="padding: 0; font: 10pt Times New Roman, Times, Serif; text-indent: 0"><FONT STYLE="font-family: Times New Roman, Times, Serif"><B>DESCRIPTION
                                           OF SECURITIES</B></FONT></TD></TR></TABLE>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0"><FONT STYLE="font-family: Times New Roman, Times, Serif"><B>&nbsp;</B></FONT></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-indent: 0.5in"><FONT STYLE="font-family: Times New Roman, Times, Serif">Not
  applicable.</FONT></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0"><FONT STYLE="font-family: Times New Roman, Times, Serif"><B>&nbsp;</B></FONT></P>
  
  <TABLE CELLPADDING="0" CELLSPACING="0" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 0; width: 100%"><TR STYLE="font: 10pt Times New Roman, Times, Serif; vertical-align: top">
  <TD STYLE="padding: 0; font: 10pt Times New Roman, Times, Serif; width: 8%; text-indent: 0"><FONT STYLE="font-family: Times New Roman, Times, Serif"><B>Item
  5.</B></FONT></TD><TD STYLE="padding: 0; font: 10pt Times New Roman, Times, Serif; text-indent: 0"><FONT STYLE="font-family: Times New Roman, Times, Serif"><B>INTERESTS
                                           OF NAMED EXPERTS AND COUNSEL</B></FONT></TD></TR></TABLE>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0"><FONT STYLE="font-family: Times New Roman, Times, Serif"><B>&nbsp;</B></FONT></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-indent: 0.5in"><FONT STYLE="font-family: Times New Roman, Times, Serif">None.</FONT></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0"><FONT STYLE="font-family: Times New Roman, Times, Serif"><B>&nbsp;</B></FONT></P>
  
  <TABLE CELLPADDING="0" CELLSPACING="0" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 0; width: 100%"><TR STYLE="font: 10pt Times New Roman, Times, Serif; vertical-align: top">
  <TD STYLE="padding: 0; font: 10pt Times New Roman, Times, Serif; width: 8%; text-indent: 0"><FONT STYLE="font-family: Times New Roman, Times, Serif"><B>Item
  6.</B></FONT></TD><TD STYLE="padding: 0; font: 10pt Times New Roman, Times, Serif; text-indent: 0"><FONT STYLE="font-family: Times New Roman, Times, Serif"><B>INDEMNIFICATION
                                           OF DIRECTORS AND OFFICERS</B></FONT></TD></TR></TABLE>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-indent: 40.5pt"><FONT STYLE="font-family: Times New Roman, Times, Serif">&nbsp;</FONT></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-indent: 0.5in"><FONT STYLE="font-family: Times New Roman, Times, Serif">The
  Registrant is incorporated under the laws of the State of Delaware. Section 145 of the Delaware General Corporation Law provides
  that a Delaware corporation may indemnify any persons who were, are, or are threatened to be made, parties to any threatened,
  pending or completed action, suit or proceeding, whether civil, criminal, administrative or investigative (other than an action
  by or in the right of such corporation), by reason of the fact that such person is or was an officer, director, employee or agent
  of such corporation, or is or was serving at the request of such corporation as an officer, director, employee or agent of another
  corporation, partnership, joint venture, trust or other enterprise. The indemnification may include expenses (including attorneys&rsquo;
  fees), judgments, fines and amounts paid in settlement actually and reasonably incurred by such person in connection with defending
  or settling such action, suit or proceeding, provided that such person acted in good faith and in a manner he or she reasonably
  believed to be in or not opposed to the corporation&rsquo;s best interests except that no indemnification is permitted without
  judicial approval if the officer or director is adjudged to be liable to the corporation. Where an officer or director is successful
  on the merits or otherwise in the defense of any action referred to above, the corporation must indemnify him or her against the
  expenses (including attorneys&rsquo; fees) actually and reasonably incurred.</FONT></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-indent: 0.5in"><FONT STYLE="font-family: Times New Roman, Times, Serif">&nbsp;</FONT></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-indent: 0.5in"><FONT STYLE="font-family: Times New Roman, Times, Serif">The
  Registrant&rsquo;s amended and restated certificate of incorporation, as amended, and amended and restated bylaws provide for
  the indemnification of its directors and officers to the fullest extent permitted under the Delaware General Corporation Law.</FONT></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-indent: 0.5in"><FONT STYLE="font-family: Times New Roman, Times, Serif">&nbsp;</FONT></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-indent: 0.5in"></P>
  
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  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-indent: 0.5in"><FONT STYLE="font-family: Times New Roman, Times, Serif">&nbsp;</FONT></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-indent: 0.5in"><FONT STYLE="font-family: Times New Roman, Times, Serif">Section
  102(b)(7) of the Delaware General Corporation Law permits a corporation to provide in its certificate of incorporation that a
  director of the corporation shall not be personally liable to the corporation or its stockholders for monetary damages for breach
  of fiduciary duties as a director, except for liability for any:</FONT></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-indent: -0.05pt"><FONT STYLE="font-family: Times New Roman, Times, Serif">&nbsp;</FONT></P>
  
  <TABLE CELLPADDING="0" CELLSPACING="0" STYLE="width: 100%; font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="font: 10pt Times New Roman, Times, Serif; vertical-align: top">
  <TD STYLE="padding: 0; font: 10pt Times New Roman, Times, Serif; width: 0.5in; text-indent: 0"></TD><TD STYLE="padding: 0; font: 10pt Times New Roman, Times, Serif; width: 0.25in; text-indent: 0"><FONT STYLE="font-family: Times New Roman, Times, Serif">&#9679;</FONT></TD><TD STYLE="padding: 0; font: 10pt Times New Roman, Times, Serif; text-align: justify; text-indent: 0"><FONT STYLE="font-family: Times New Roman, Times, Serif">Breach
                                           of the director&rsquo;s duty of loyalty to the corporation or its stockholders;</FONT></TD></TR></TABLE>
  
  <P STYLE="margin-right: 0; font: 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 0"><FONT STYLE="font-family: Times New Roman, Times, Serif">&nbsp;</FONT></P>
  
  <TABLE CELLPADDING="0" CELLSPACING="0" STYLE="width: 100%; font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="font: 10pt Times New Roman, Times, Serif; vertical-align: top">
  <TD STYLE="padding: 0; font: 10pt Times New Roman, Times, Serif; width: 0.5in; text-indent: 0"></TD><TD STYLE="padding: 0; font: 10pt Times New Roman, Times, Serif; width: 0.25in; text-indent: 0"><FONT STYLE="font-family: Times New Roman, Times, Serif">&#9679;</FONT></TD><TD STYLE="padding: 0; font: 10pt Times New Roman, Times, Serif; text-align: justify; text-indent: 0"><FONT STYLE="font-family: Times New Roman, Times, Serif">Act
                                           or omission not in good faith or that involves intentional misconduct or a knowing violation
                                           of law;</FONT></TD></TR></TABLE>
  
  <P STYLE="margin-right: 0; font: 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 0"><FONT STYLE="font-family: Times New Roman, Times, Serif">&nbsp;</FONT></P>
  
  <TABLE CELLPADDING="0" CELLSPACING="0" STYLE="width: 100%; font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="font: 10pt Times New Roman, Times, Serif; vertical-align: top">
  <TD STYLE="padding: 0; font: 10pt Times New Roman, Times, Serif; width: 0.5in; text-indent: 0"></TD><TD STYLE="padding: 0; font: 10pt Times New Roman, Times, Serif; width: 0.25in; text-indent: 0"><FONT STYLE="font-family: Times New Roman, Times, Serif">&#9679;</FONT></TD><TD STYLE="padding: 0; font: 10pt Times New Roman, Times, Serif; text-align: justify; text-indent: 0"><FONT STYLE="font-family: Times New Roman, Times, Serif">Unlawful
                                           payment of dividends or unlawful stock purchase or redemption; or</FONT></TD></TR></TABLE>
  
  <P STYLE="margin-right: 0; font: 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 0"><FONT STYLE="font-family: Times New Roman, Times, Serif">&nbsp;</FONT></P>
  
  <TABLE CELLPADDING="0" CELLSPACING="0" STYLE="width: 100%; font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="font: 10pt Times New Roman, Times, Serif; vertical-align: top">
  <TD STYLE="padding: 0; font: 10pt Times New Roman, Times, Serif; width: 0.5in; text-indent: 0"></TD><TD STYLE="padding: 0; font: 10pt Times New Roman, Times, Serif; width: 0.25in; text-indent: 0"><FONT STYLE="font-family: Times New Roman, Times, Serif">&#9679;</FONT></TD><TD STYLE="padding: 0; font: 10pt Times New Roman, Times, Serif; text-align: justify; text-indent: 0"><FONT STYLE="font-family: Times New Roman, Times, Serif">Transaction
                                           from which the director derives an improper personal benefit.</FONT></TD></TR></TABLE>
  
  <P STYLE="margin-right: 0; font: 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 0"><FONT STYLE="font-family: Times New Roman, Times, Serif">&nbsp;</FONT></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-indent: 0.5in"><FONT STYLE="font-family: Times New Roman, Times, Serif">The
  Registrant&rsquo;s amended and restated certificate of incorporation, as amended, includes such a provision. Expenses incurred
  by any officer or director in defending any such action, suit or proceeding in advance of its final disposition shall be paid
  by the Registrant upon delivery to it of an undertaking, by or on behalf of such director or officer, to repay all amounts so
  advanced if it shall ultimately be determined that such director or officer is not entitled to be indemnified by the Registrant.</FONT></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-indent: 0.5in"><FONT STYLE="font-family: Times New Roman, Times, Serif">&nbsp;</FONT></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-indent: 0.5in"><FONT STYLE="font-family: Times New Roman, Times, Serif">Section
  174 of the Delaware General Corporation Law provides, among other things, that a director who willfully or negligently approves
  an unlawful payment of dividends or an unlawful stock purchase or redemption, may be held jointly and severally liable for such
  actions. A director who was either absent when the unlawful actions were approved or dissented at the time may avoid liability
  by causing his or her dissent to such actions to be entered in the books containing minutes of the meetings of the board of directors
  at the time such action occurred or immediately after such absent director receives notice of the unlawful acts.</FONT></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-indent: 0.5in"><FONT STYLE="font-family: Times New Roman, Times, Serif">&nbsp;</FONT></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-indent: 0.5in"><FONT STYLE="font-family: Times New Roman, Times, Serif">As
  permitted by the Delaware General Corporation Law, the Registrant has entered into indemnification agreements with each of its
  directors and executive officers that require the Registrant to indemnify such persons against any and all costs and expenses
  (including attorneys&rsquo;, witness or other professional fees) actually and reasonably incurred by such persons in connection
  with any action, suit or proceeding (including derivative actions), whether actual or threatened, to which any such person may
  be made a party by reason of the fact that such person is or was a director or officer or is or was acting or serving as an officer,
  director, employee or agent of the Registrant or any of its affiliated enterprises. Under these agreements, the Registrant is
  not required to provide indemnification for certain matters, including:</FONT></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-indent: 0.5in"><FONT STYLE="font-family: Times New Roman, Times, Serif">&nbsp;</FONT></P>
  
  <TABLE CELLPADDING="0" CELLSPACING="0" STYLE="width: 100%; font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="font: 10pt Times New Roman, Times, Serif; vertical-align: top">
  <TD STYLE="padding: 0; font: 10pt Times New Roman, Times, Serif; width: 0.5in; text-indent: 0"></TD><TD STYLE="padding: 0; font: 10pt Times New Roman, Times, Serif; width: 0.25in; text-indent: 0"><FONT STYLE="font-family: Times New Roman, Times, Serif">&#9679;</FONT></TD><TD STYLE="padding: 0; font: 10pt Times New Roman, Times, Serif; text-align: justify; text-indent: 0"><FONT STYLE="font-family: Times New Roman, Times, Serif">Indemnification
                                           for expenses or losses with respect to proceedings initiated by the director or officer,
                                           including any proceedings against the Registrant or its directors, officers, employees
                                           or other indemnitees and not by way of defense, with certain exceptions;</FONT></TD></TR></TABLE>
  
  <P STYLE="margin-right: 0; font: 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 0"><FONT STYLE="font-family: Times New Roman, Times, Serif">&nbsp;</FONT></P>
  
  <TABLE CELLPADDING="0" CELLSPACING="0" STYLE="width: 100%; font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="font: 10pt Times New Roman, Times, Serif; vertical-align: top">
  <TD STYLE="padding: 0; font: 10pt Times New Roman, Times, Serif; width: 0.5in; text-indent: 0"></TD><TD STYLE="padding: 0; font: 10pt Times New Roman, Times, Serif; width: 0.25in; text-indent: 0"><FONT STYLE="font-family: Times New Roman, Times, Serif">&#9679;</FONT></TD><TD STYLE="padding: 0; font: 10pt Times New Roman, Times, Serif; text-align: justify; text-indent: 0"><FONT STYLE="font-family: Times New Roman, Times, Serif">Indemnification
                                           for any proceeding if a final decision by a court of competent jurisdiction determines
                                           that such indemnification is prohibited by applicable law;</FONT></TD></TR></TABLE>
  
  <P STYLE="margin-right: 0; font: 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 0"><FONT STYLE="font-family: Times New Roman, Times, Serif">&nbsp;</FONT></P>
  
  <TABLE CELLPADDING="0" CELLSPACING="0" STYLE="width: 100%; font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="font: 10pt Times New Roman, Times, Serif; vertical-align: top">
  <TD STYLE="padding: 0; font: 10pt Times New Roman, Times, Serif; width: 0.5in; text-indent: 0"></TD><TD STYLE="padding: 0; font: 10pt Times New Roman, Times, Serif; width: 0.25in; text-indent: 0"><FONT STYLE="font-family: Times New Roman, Times, Serif">&#9679;</FONT></TD><TD STYLE="padding: 0; font: 10pt Times New Roman, Times, Serif; text-align: justify; text-indent: 0"><FONT STYLE="font-family: Times New Roman, Times, Serif">Indemnification
                                           for the disgorgement of profits arising from the purchase or sale by the director or
                                           officer of securities of the Registrant in violation of Section 16(b) of the Exchange
                                           Act, or any similar successor statute; or</FONT></TD></TR></TABLE>
  
  <P STYLE="margin-right: 0; font: 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 0"><FONT STYLE="font-family: Times New Roman, Times, Serif">&nbsp;</FONT></P>
  
  <TABLE CELLPADDING="0" CELLSPACING="0" STYLE="width: 100%; font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="font: 10pt Times New Roman, Times, Serif; vertical-align: top">
  <TD STYLE="padding: 0; font: 10pt Times New Roman, Times, Serif; width: 0.5in; text-indent: 0"></TD><TD STYLE="padding: 0; font: 10pt Times New Roman, Times, Serif; width: 0.25in; text-indent: 0"><FONT STYLE="font-family: Times New Roman, Times, Serif">&#9679;</FONT></TD><TD STYLE="padding: 0; font: 10pt Times New Roman, Times, Serif; text-align: justify; text-indent: 0"><FONT STYLE="font-family: Times New Roman, Times, Serif">Indemnification
                                           for the director or officer&rsquo;s reimbursement to the Registrant of any bonus or other
                                           incentive-based or equity-based compensation previously received by the director or officer
                                           or payment of any profits realized by the director or officer from the sale of securities
                                           of the Registrant, as required in each case under the Exchange Act.</FONT></TD></TR></TABLE>
  
  <P STYLE="margin-right: 0; font: 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 0"><FONT STYLE="font-family: Times New Roman, Times, Serif">&nbsp;</FONT></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-indent: 0.5in"><FONT STYLE="font-family: Times New Roman, Times, Serif">The
  indemnification agreements also set forth certain procedures that will apply in the event of a claim for indemnification thereunder.
  The Registrant has an insurance policy in place, with limits of $20.0 million in the aggregate, that covers its officers and directors
  with respect to certain liabilities, including liabilities arising under the Securities Act of 1933, as amended (the &ldquo;<U>Securities
  Act</U>&rdquo;) or otherwise. Insofar as indemnification for liabilities arising under the Securities Act may be permitted to
  directors, officers and controlling persons of the Registrant pursuant to the foregoing provisions, or otherwise, the Registrant
  has been advised that in the opinion of the Commission such indemnification is against public policy as expressed in the Securities
  Act and is, therefore, unenforceable.</FONT></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-indent: 0.5in"><FONT STYLE="font-family: Times New Roman, Times, Serif">&nbsp;&nbsp;</FONT></P>
  
  <TABLE CELLPADDING="0" CELLSPACING="0" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 0; width: 100%"><TR STYLE="font: 10pt Times New Roman, Times, Serif; vertical-align: top">
  <TD STYLE="padding: 0; font: 10pt Times New Roman, Times, Serif; width: 8%; text-indent: 0"><FONT STYLE="font-family: Times New Roman, Times, Serif"><B>Item
  7.</B></FONT></TD><TD STYLE="padding: 0; font: 10pt Times New Roman, Times, Serif; text-indent: 0"><FONT STYLE="font-family: Times New Roman, Times, Serif"><B>EXEMPTIONS
                                           FROM REGISTRATION CLAIMED</B></FONT></TD></TR></TABLE>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0"><FONT STYLE="font-family: Times New Roman, Times, Serif">&nbsp;</FONT></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-indent: 0.5in"><FONT STYLE="font-family: Times New Roman, Times, Serif">Not
  applicable.</FONT></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0"><FONT STYLE="font-family: Times New Roman, Times, Serif">&nbsp;</FONT></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0"></P>
  
  <!-- Field: Page; Sequence: 4; Value: 1 -->
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      <DIV STYLE="page-break-before: always; margin-top: 6pt; margin-bottom: 12pt"><P STYLE="margin: 0pt">&nbsp;</P></DIV>
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  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0"><FONT STYLE="font-family: Times New Roman, Times, Serif"><B>&nbsp;</B></FONT></P>
  
  <TABLE CELLPADDING="0" CELLSPACING="0" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 0; width: 100%"><TR STYLE="vertical-align: top; text-align: justify">
  <TD STYLE="width: 8%; text-align: left"><FONT STYLE="font-family: Times New Roman, Times, Serif"><B>Item 8.</B></FONT></TD><TD STYLE="text-align: justify"><FONT STYLE="font-family: Times New Roman, Times, Serif"><B>EXHIBITS</B></FONT></TD>
  </TR></TABLE>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0"><FONT STYLE="font-family: Times New Roman, Times, Serif"><B>&nbsp;</B></FONT></P>
  
  <TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
  <TR STYLE="font: 10pt Times New Roman, Times, Serif; vertical-align: bottom">
      <TD STYLE="border-bottom: Black 1.5pt solid; font: 10pt Times New Roman, Times, Serif; padding-top: 0; padding-right: 0; padding-left: 0; text-align: center"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt"><B>Exhibit
      Number</B></FONT></TD>
      <TD STYLE="font: 10pt Times New Roman, Times, Serif; padding: 0 0 1.5pt; text-align: center; text-indent: 0"><FONT STYLE="font-family: Times New Roman, Times, Serif">&nbsp;</FONT></TD>
      <TD STYLE="border-bottom: Black 1.5pt solid; padding-top: 0; padding-right: 0; font: 10pt Times New Roman, Times, Serif; padding-left: 0; text-align: center; text-indent: 0"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt"><B><BR>
      Description</B></FONT></TD></TR>
  <TR STYLE="font: 10pt Times New Roman, Times, Serif">
      <TD STYLE="font: 10pt Times New Roman, Times, Serif; padding: 0; vertical-align: top; width: 9%; text-align: center"><FONT STYLE="font-family: Times New Roman, Times, Serif">&nbsp;</FONT></TD>
      <TD STYLE="padding: 0; font: 10pt Times New Roman, Times, Serif; vertical-align: bottom; width: 1%; text-indent: 0"><FONT STYLE="font-family: Times New Roman, Times, Serif">&nbsp;</FONT></TD>
      <TD STYLE="padding: 0; font: 10pt Times New Roman, Times, Serif; vertical-align: top; width: 90%; text-indent: 0"><FONT STYLE="font-family: Times New Roman, Times, Serif">&nbsp;</FONT></TD></TR>
  <TR STYLE="font: 10pt Times New Roman, Times, Serif; background-color: rgb(204,238,255)">
      <TD STYLE="font: 10pt Times New Roman, Times, Serif; padding: 0; vertical-align: top; text-align: center"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">5.1+</FONT></TD>
      <TD STYLE="padding: 0; font: 10pt Times New Roman, Times, Serif; vertical-align: bottom; text-indent: 0"><FONT STYLE="font-family: Times New Roman, Times, Serif">&nbsp;</FONT></TD>
      <TD STYLE="padding: 0; font: 10pt Times New Roman, Times, Serif; vertical-align: top; text-indent: 0"><A HREF="ea125527ex5-1_senestechinc.htm"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">Opinion of Perkins Coie LLP regarding legality of the common stock being registered</FONT></A></TD></TR>
  <TR STYLE="font: 10pt Times New Roman, Times, Serif; background-color: White">
      <TD STYLE="font: 10pt Times New Roman, Times, Serif; padding: 0; vertical-align: top; text-align: center"><FONT STYLE="font-family: Times New Roman, Times, Serif">&nbsp;</FONT></TD>
      <TD STYLE="padding: 0; font: 10pt Times New Roman, Times, Serif; vertical-align: bottom; text-indent: 0"><FONT STYLE="font-family: Times New Roman, Times, Serif">&nbsp;</FONT></TD>
      <TD STYLE="padding: 0; font: 10pt Times New Roman, Times, Serif; vertical-align: top; text-indent: 0"><FONT STYLE="font-family: Times New Roman, Times, Serif">&nbsp;</FONT></TD></TR>
  <TR STYLE="font: 10pt Times New Roman, Times, Serif; background-color: rgb(204,238,255)">
      <TD STYLE="font: 10pt Times New Roman, Times, Serif; padding: 0; vertical-align: top; text-align: center"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">23.1+</FONT></TD>
      <TD STYLE="padding: 0; font: 10pt Times New Roman, Times, Serif; vertical-align: bottom; text-indent: 0"><FONT STYLE="font-family: Times New Roman, Times, Serif">&nbsp;</FONT></TD>
      <TD STYLE="padding: 0; font: 10pt Times New Roman, Times, Serif; vertical-align: top; text-indent: 0"><A HREF="ea125527ex23-1_senestechinc.htm"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">Consent of M&amp;K CPAS, PLLC</FONT></A></TD></TR>
  <TR STYLE="font: 10pt Times New Roman, Times, Serif; background-color: White">
      <TD STYLE="font: 10pt Times New Roman, Times, Serif; padding: 0; vertical-align: top; text-align: center"><FONT STYLE="font-family: Times New Roman, Times, Serif">&nbsp;</FONT></TD>
      <TD STYLE="padding: 0; font: 10pt Times New Roman, Times, Serif; vertical-align: bottom; text-indent: 0"><FONT STYLE="font-family: Times New Roman, Times, Serif">&nbsp;</FONT></TD>
      <TD STYLE="padding: 0; font: 10pt Times New Roman, Times, Serif; vertical-align: top; text-indent: 0"><FONT STYLE="font-family: Times New Roman, Times, Serif">&nbsp;</FONT></TD></TR>
  <TR STYLE="font: 10pt Times New Roman, Times, Serif; background-color: rgb(204,238,255)">
      <TD STYLE="font: 10pt Times New Roman, Times, Serif; padding: 0; vertical-align: top; text-align: center"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">23.2+</FONT></TD>
      <TD STYLE="padding: 0; font: 10pt Times New Roman, Times, Serif; vertical-align: bottom; text-indent: 0"><FONT STYLE="font-family: Times New Roman, Times, Serif">&nbsp;</FONT></TD>
      <TD STYLE="padding: 0; font: 10pt Times New Roman, Times, Serif; vertical-align: top; text-indent: 0"><A HREF="ea125527ex5-1_senestechinc.htm"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">Consent of Perkins Coie LLP (included in opinion filed as Exhibit&nbsp;5.1)</FONT></A></TD></TR>
  <TR STYLE="font: 10pt Times New Roman, Times, Serif; background-color: White">
      <TD STYLE="font: 10pt Times New Roman, Times, Serif; padding: 0; vertical-align: top; text-align: center"><FONT STYLE="font-family: Times New Roman, Times, Serif">&nbsp;</FONT></TD>
      <TD STYLE="padding: 0; font: 10pt Times New Roman, Times, Serif; vertical-align: bottom; text-indent: 0"><FONT STYLE="font-family: Times New Roman, Times, Serif">&nbsp;</FONT></TD>
      <TD STYLE="padding: 0; font: 10pt Times New Roman, Times, Serif; vertical-align: top; text-indent: 0"><FONT STYLE="font-family: Times New Roman, Times, Serif">&nbsp;</FONT></TD></TR>
  <TR STYLE="font: 10pt Times New Roman, Times, Serif; background-color: rgb(204,238,255)">
      <TD STYLE="font: 10pt Times New Roman, Times, Serif; padding: 0; vertical-align: top; text-align: center"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">24.1+</FONT></TD>
      <TD STYLE="padding: 0; font: 10pt Times New Roman, Times, Serif; vertical-align: bottom; text-indent: 0"><FONT STYLE="font-family: Times New Roman, Times, Serif">&nbsp;</FONT></TD>
      <TD STYLE="padding: 0; font: 10pt Times New Roman, Times, Serif; vertical-align: top; text-indent: 0"><A HREF="#a_001"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">Power of Attorney (see signature page)</FONT></A></TD></TR>
  <TR STYLE="font: 10pt Times New Roman, Times, Serif; background-color: White">
      <TD STYLE="font: 10pt Times New Roman, Times, Serif; padding: 0; vertical-align: top; text-align: center"><FONT STYLE="font-family: Times New Roman, Times, Serif">&nbsp;</FONT></TD>
      <TD STYLE="padding: 0; font: 10pt Times New Roman, Times, Serif; vertical-align: bottom; text-indent: 0"><FONT STYLE="font-family: Times New Roman, Times, Serif">&nbsp;</FONT></TD>
      <TD STYLE="padding: 0; font: 10pt Times New Roman, Times, Serif; vertical-align: top; text-indent: 0"><FONT STYLE="font-family: Times New Roman, Times, Serif">&nbsp;</FONT></TD></TR>
  <TR STYLE="font: 10pt Times New Roman, Times, Serif; background-color: rgb(204,238,255)">
      <TD STYLE="font: 10pt Times New Roman, Times, Serif; padding: 0; vertical-align: top; text-align: center"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">99.1*</FONT></TD>
      <TD STYLE="padding: 0; font: 10pt Times New Roman, Times, Serif; vertical-align: bottom; text-indent: 0"><FONT STYLE="font-family: Times New Roman, Times, Serif">&nbsp;</FONT></TD>
      <TD STYLE="padding: 0; font: 10pt Times New Roman, Times, Serif; vertical-align: top; text-indent: 0"><FONT STYLE="font-family: Times New Roman, Times, Serif"><A HREF="http://www.sec.gov/Archives/edgar/data/1680378/000121390020021758/f10q0620ex10-3_senestech.htm"><FONT STYLE="font-size: 10pt">SenesTech,
      Inc. 2018 Equity Incentive Plan, as amended (incorporated by reference to Exhibit 10.3 to the Registrant&rsquo;s Quarterly
      Report on Form 10-Q filed with the Commission on August 13, 2020)</FONT></A></FONT></TD></TR>
  </TABLE>
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0"><FONT STYLE="font-family: Times New Roman, Times, Serif">&nbsp;</FONT></P>
  
  <TABLE CELLPADDING="0" CELLSPACING="0" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 0; width: 100%"><TR STYLE="vertical-align: top; text-align: justify">
  <TD STYLE="width: 0.25in; text-align: left"><FONT STYLE="font-family: Times New Roman, Times, Serif">+</FONT></TD><TD STYLE="text-align: justify"><FONT STYLE="font-family: Times New Roman, Times, Serif">Filed
                                           herewith.</FONT></TD>
  </TR>
  <TR STYLE="vertical-align: top; text-align: justify">
  <TD STYLE="text-align: left"><FONT STYLE="font-family: Times New Roman, Times, Serif">*</FONT></TD><TD STYLE="text-align: justify"><FONT STYLE="font-family: Times New Roman, Times, Serif">Incorporated
                                           herein by reference.</FONT></TD>
  </TR></TABLE>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0"><FONT STYLE="font-family: Times New Roman, Times, Serif">&nbsp;</FONT></P>
  
  <TABLE CELLPADDING="0" CELLSPACING="0" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 0; width: 100%"><TR STYLE="font: 10pt Times New Roman, Times, Serif; vertical-align: top">
  <TD STYLE="padding: 0; font: 10pt Times New Roman, Times, Serif; width: 8%; text-indent: 0"><FONT STYLE="font-family: Times New Roman, Times, Serif"><B>Item
  9.</B></FONT></TD><TD STYLE="padding: 0; font: 10pt Times New Roman, Times, Serif; text-indent: 0"><FONT STYLE="font-family: Times New Roman, Times, Serif"><B>UNDERTAKINGS</B></FONT></TD></TR></TABLE>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0"><FONT STYLE="font-family: Times New Roman, Times, Serif">&nbsp;</FONT></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0"><FONT STYLE="font-family: Times New Roman, Times, Serif">A. The
  undersigned Registrant hereby undertakes:</FONT></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0"><FONT STYLE="font-family: Times New Roman, Times, Serif">&nbsp;</FONT></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-indent: 0.5in"><FONT STYLE="font-family: Times New Roman, Times, Serif">(1)
  To file, during any period in which offers or sales are being made, a post-effective amendment to this Registration Statement:</FONT></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0"><FONT STYLE="font-family: Times New Roman, Times, Serif">&nbsp;</FONT></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-indent: 1in"><FONT STYLE="font-family: Times New Roman, Times, Serif">(a)
  To include any prospectus required by Section&nbsp;10(a)(3)&nbsp;of the Securities Act;</FONT></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center"><FONT STYLE="font-family: Times New Roman, Times, Serif">&nbsp;</FONT></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-indent: 1in"><FONT STYLE="font-family: Times New Roman, Times, Serif">(b)
  To reflect in the prospectus any facts or events arising after the effective date of this Registration Statement (or the most
  recent post-effective amendment thereof) which, individually or in the aggregate, represent a fundamental change in the information
  set forth in this Registration Statement; and</FONT></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center"><FONT STYLE="font-family: Times New Roman, Times, Serif">&nbsp;</FONT></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-indent: 1in"><FONT STYLE="font-family: Times New Roman, Times, Serif">(c)
  To include any material information with respect to the plan of distribution not previously disclosed in this Registration Statement
  or any material change to such information in this Registration Statement;</FONT></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-indent: 1in"><FONT STYLE="font-family: Times New Roman, Times, Serif">&nbsp;</FONT></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0"><FONT STYLE="font-family: Times New Roman, Times, Serif"><U>provided</U>,&nbsp;<U>however</U>,
  that paragraphs (1)(a)&nbsp;and (1)(b)&nbsp;above do not apply if the information required to be included in a post-effective
  amendment by those paragraphs is contained in reports filed with or furnished to the Commission by the Registrant pursuant to
  Section&nbsp;13 or&nbsp;15(d)&nbsp;of the Exchange Act that are incorporated by reference in this Registration Statement.</FONT></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0"><FONT STYLE="font-family: Times New Roman, Times, Serif">&nbsp;</FONT></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-indent: 0.5in"><FONT STYLE="font-family: Times New Roman, Times, Serif">(2)
  That, for the purpose of determining any liability under the Securities Act, each such post-effective amendment shall be deemed
  to be a new registration statement relating to the securities offered therein, and the offering of such securities at that time
  shall be deemed to be the initial bona fide offering thereof.</FONT></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0"><FONT STYLE="font-family: Times New Roman, Times, Serif">&nbsp;</FONT></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-indent: 0.5in"><FONT STYLE="font-family: Times New Roman, Times, Serif">(3)
  To remove from registration by means of a post-effective amendment any of the securities being registered which remain unsold
  at the termination of the offering.</FONT></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0"><FONT STYLE="font-family: Times New Roman, Times, Serif">&nbsp;</FONT></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0"><FONT STYLE="font-family: Times New Roman, Times, Serif">B. The
  undersigned Registrant hereby undertakes that, for purposes of determining any liability under the Securities Act, each filing
  of the Registrant&rsquo;s annual report pursuant to Section&nbsp;13(a)&nbsp;or Section 15(d)&nbsp;of the Exchange Act (and, where
  applicable, each filing of an employee benefits plan&rsquo;s annual report pursuant to Section&nbsp;15(d)&nbsp;of the Exchange
  Act) that is incorporated by reference in this Registration Statement shall be deemed to be a new registration statement relating
  to the securities offered therein, and the offering of such securities at that time shall be deemed to be the initial bona fide
  offering thereof.</FONT></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0"><FONT STYLE="font-family: Times New Roman, Times, Serif">&nbsp;</FONT></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0"><FONT STYLE="font-family: Times New Roman, Times, Serif">C. Insofar
  as indemnification for liabilities arising under the Securities Act may be permitted to directors, officers and controlling persons
  of the Registrant pursuant to the foregoing provisions, or otherwise, the Registrant has been advised that, in the opinion of
  the Commission, such indemnification is against public policy as expressed in the Securities Act and is, therefore, unenforceable.
  In the event that a claim for indemnification against such liabilities (other than the payment by the Registrant of expenses incurred
  or paid by a director, officer or controlling person of the Registrant in the successful defense of any action, suit or proceeding)
  is asserted by such director, officer or controlling person in connection with the securities being registered, the Registrant
  will, unless in the opinion of its counsel the matter has been settled by controlling precedent, submit to a court of appropriate
  jurisdiction the question whether such indemnification by it is against public policy as expressed in the Securities Act and will
  be governed by the final adjudication of such issue.</FONT></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0"><FONT STYLE="font-family: Times New Roman, Times, Serif">&nbsp;</FONT></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0"></P>
  
  <!-- Field: Page; Sequence: 5; Value: 1 -->
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      <DIV STYLE="page-break-before: always; margin-top: 6pt; margin-bottom: 12pt"><P STYLE="margin: 0pt">&nbsp;</P></DIV>
      <!-- Field: /Page -->
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0"></P>
  
  
  
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0"><FONT STYLE="font-family: Times New Roman, Times, Serif"><B>&nbsp;</B></FONT></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center"><FONT STYLE="font-family: Times New Roman, Times, Serif"><B>SIGNATURES</B></FONT></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center"><FONT STYLE="font-family: Times New Roman, Times, Serif">&nbsp;</FONT></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-indent: 0.5in"><FONT STYLE="font-family: Times New Roman, Times, Serif">Pursuant
  to the requirements of the Securities Act of 1933, the Registrant certifies that it has reasonable grounds to believe that it
  meets all the requirements for filing on Form&nbsp;S-8 and has duly caused this Registration Statement to be signed on its behalf
  by the undersigned, thereunto duly authorized, in the City of Phoenix, State of Arizona, on August 14, 2020.</FONT></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-indent: 0.5in"><FONT STYLE="font-family: Times New Roman, Times, Serif">&nbsp;</FONT></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-indent: 0.5in"></P>
  
  <TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%">
  <TR STYLE="vertical-align: top">
      <TD STYLE="padding: 0; text-indent: 0"><FONT STYLE="font-family: Times New Roman, Times, Serif">&nbsp;</FONT></TD>
      <TD COLSPAN="2" STYLE="padding: 0; text-indent: 0"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt"><B>SENESTECH,
      INC.</B></FONT></TD></TR>
  <TR STYLE="vertical-align: top">
      <TD STYLE="padding: 0; width: 60%; text-indent: 0"><FONT STYLE="font-family: Times New Roman, Times, Serif">&nbsp;</FONT></TD>
      <TD STYLE="padding: 0; width: 4%; text-indent: 0"><FONT STYLE="font-family: Times New Roman, Times, Serif">&nbsp;</FONT></TD>
      <TD STYLE="padding: 0; text-indent: 0; width: 36%"><FONT STYLE="font-family: Times New Roman, Times, Serif">&nbsp;</FONT></TD></TR>
  <TR STYLE="vertical-align: top">
      <TD STYLE="padding: 0; text-indent: 0"><FONT STYLE="font-family: Times New Roman, Times, Serif">&nbsp;</FONT></TD>
      <TD STYLE="padding: 0; text-indent: 0"><FONT STYLE="font-family: Times New Roman, Times, Serif">&nbsp;</FONT></TD>
      <TD STYLE="border-bottom: Black 1.5pt solid; padding: 0; text-indent: 0"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">/s/
      Kenneth Siegel</FONT></TD></TR>
  <TR STYLE="vertical-align: top">
      <TD STYLE="padding: 0; text-indent: 0"><FONT STYLE="font-family: Times New Roman, Times, Serif">&nbsp;</FONT></TD>
      <TD STYLE="padding: 0; text-indent: 0"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">By:</FONT></TD>
      <TD STYLE="padding: 0; text-indent: 0"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">Kenneth Siegel</FONT></TD></TR>
  <TR STYLE="vertical-align: top">
      <TD STYLE="padding: 0; text-indent: 0"><FONT STYLE="font-family: Times New Roman, Times, Serif">&nbsp;</FONT></TD>
      <TD STYLE="padding: 0; text-indent: 0"><FONT STYLE="font-family: Times New Roman, Times, Serif">&nbsp;</FONT></TD>
      <TD STYLE="padding: 0; text-indent: 0"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">Chief Executive
      Officer&#9;</FONT></TD></TR>
  </TABLE>
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-indent: 0.5in"><FONT STYLE="font-family: Times New Roman, Times, Serif">&nbsp;&nbsp;</FONT></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 0; text-align: center"><A NAME="a_001"></A><FONT STYLE="font-family: Times New Roman, Times, Serif"><B>POWER
  OF ATTORNEY</B></FONT></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center"><FONT STYLE="font-family: Times New Roman, Times, Serif">&nbsp;</FONT></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-indent: 0.5in"><FONT STYLE="font-family: Times New Roman, Times, Serif">Each
  person whose signature appears below authorizes Kenneth Siegel and Thomas C. Chesterman, or either of them, as attorneys-in-fact
  with full power of substitution, to execute in the name and on the behalf of each person, individually and in each capacity stated
  below, and to file, any and all amendments to this Registration Statement, including any and all post-effective amendments.</FONT></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0"><FONT STYLE="font-family: Times New Roman, Times, Serif">&nbsp;</FONT></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-indent: 0.5in"><FONT STYLE="font-family: Times New Roman, Times, Serif">Pursuant
  to the requirements of the Securities Act of 1933, this Registration Statement has been signed by the following persons in the
  capacities indicated below on August 14, 2020.</FONT></P>
  
  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center"><FONT STYLE="font-family: Times New Roman, Times, Serif">&nbsp;</FONT></P>
  
  <TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
  <TR STYLE="font: 10pt Times New Roman, Times, Serif">
      <TD STYLE="border-bottom: Black 1.5pt solid; padding-top: 0; padding-right: 0; font: 10pt Times New Roman, Times, Serif; padding-left: 0; vertical-align: top; width: 45%; text-align: center; text-indent: 0"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt"><B>Signature</B></FONT></TD>
      <TD STYLE="font: 10pt Times New Roman, Times, Serif; padding: 0 0 1.5pt; vertical-align: bottom; width: 1%; text-align: center; text-indent: 0"><FONT STYLE="font-family: Times New Roman, Times, Serif">&nbsp;</FONT></TD>
      <TD STYLE="border-bottom: Black 1.5pt solid; padding-top: 0; padding-right: 0; font: 10pt Times New Roman, Times, Serif; padding-left: 0; vertical-align: top; width: 54%; text-align: center; text-indent: 0"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt"><B>Title</B></FONT></TD></TR>
  <TR STYLE="font: 10pt Times New Roman, Times, Serif">
      <TD STYLE="padding: 0; font: 10pt Times New Roman, Times, Serif; vertical-align: top; text-indent: 0"><FONT STYLE="font-family: Times New Roman, Times, Serif">&nbsp;</FONT></TD>
      <TD STYLE="padding: 0; font: 10pt Times New Roman, Times, Serif; vertical-align: bottom; text-indent: 0"><FONT STYLE="font-family: Times New Roman, Times, Serif">&nbsp;</FONT></TD>
      <TD STYLE="padding: 0; font: 10pt Times New Roman, Times, Serif; vertical-align: top; text-align: center; text-indent: 0"><FONT STYLE="font-family: Times New Roman, Times, Serif">&nbsp;</FONT></TD></TR>
  <TR STYLE="font: 10pt Times New Roman, Times, Serif">
      <TD STYLE="border-bottom: Black 1.5pt solid; padding: 0; font: 10pt Times New Roman, Times, Serif; vertical-align: top; text-align: center; text-indent: 0"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">/s/
      Kenneth Siegel</FONT></TD>
      <TD STYLE="padding: 0; font: 10pt Times New Roman, Times, Serif; vertical-align: bottom; text-indent: 0"><FONT STYLE="font-family: Times New Roman, Times, Serif">&nbsp;</FONT></TD>
      <TD STYLE="padding: 0; font: 10pt Times New Roman, Times, Serif; vertical-align: top; text-align: center; text-indent: 0"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">Chief
      Executive Officer and Director</FONT></TD></TR>
  <TR STYLE="font: 10pt Times New Roman, Times, Serif">
      <TD STYLE="padding: 0; font: 10pt Times New Roman, Times, Serif; vertical-align: top; text-align: center; text-indent: 0"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">Kenneth
      Siegel</FONT></TD>
      <TD STYLE="padding: 0; font: 10pt Times New Roman, Times, Serif; vertical-align: bottom; text-indent: 0"><FONT STYLE="font-family: Times New Roman, Times, Serif">&nbsp;</FONT></TD>
      <TD STYLE="padding: 0; font: 10pt Times New Roman, Times, Serif; vertical-align: top; text-align: center; text-indent: 0"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">(Principal
      Executive Officer)</FONT></TD></TR>
  <TR STYLE="font: 10pt Times New Roman, Times, Serif">
      <TD STYLE="padding: 0; font: 10pt Times New Roman, Times, Serif; vertical-align: top; text-align: center; text-indent: 0"><FONT STYLE="font-family: Times New Roman, Times, Serif">&nbsp;</FONT></TD>
      <TD STYLE="padding: 0; font: 10pt Times New Roman, Times, Serif; vertical-align: bottom; text-indent: 0"><FONT STYLE="font-family: Times New Roman, Times, Serif">&nbsp;</FONT></TD>
      <TD STYLE="padding: 0; font: 10pt Times New Roman, Times, Serif; vertical-align: top; text-align: center; text-indent: 0"><FONT STYLE="font-family: Times New Roman, Times, Serif">&nbsp;</FONT></TD></TR>
  <TR STYLE="font: 10pt Times New Roman, Times, Serif">
      <TD STYLE="border-bottom: Black 1.5pt solid; padding: 0; font: 10pt Times New Roman, Times, Serif; vertical-align: top; text-align: center; text-indent: 0"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">/s/
      Thomas C. Chesterman</FONT></TD>
      <TD STYLE="padding: 0; font: 10pt Times New Roman, Times, Serif; vertical-align: bottom; text-indent: 0"><FONT STYLE="font-family: Times New Roman, Times, Serif">&nbsp;</FONT></TD>
      <TD STYLE="padding: 0; font: 10pt Times New Roman, Times, Serif; vertical-align: top; text-align: center; text-indent: 0"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">Chief
      Financial Officer and Treasurer </FONT></TD></TR>
  <TR STYLE="font: 10pt Times New Roman, Times, Serif">
      <TD STYLE="padding: 0; font: 10pt Times New Roman, Times, Serif; vertical-align: top; text-align: center; text-indent: 0"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">Thomas
      C. Chesterman</FONT></TD>
      <TD STYLE="padding: 0; font: 10pt Times New Roman, Times, Serif; vertical-align: bottom; text-indent: 0"><FONT STYLE="font-family: Times New Roman, Times, Serif">&nbsp;</FONT></TD>
      <TD STYLE="padding: 0; font: 10pt Times New Roman, Times, Serif; vertical-align: top; text-align: center; text-indent: 0"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">(Principal
      Financial and Accounting Officer)</FONT></TD></TR>
  <TR STYLE="font: 10pt Times New Roman, Times, Serif">
      <TD STYLE="padding: 0; font: 10pt Times New Roman, Times, Serif; vertical-align: top; text-align: center; text-indent: 0"><FONT STYLE="font-family: Times New Roman, Times, Serif">&nbsp;</FONT></TD>
      <TD STYLE="padding: 0; font: 10pt Times New Roman, Times, Serif; vertical-align: bottom; text-indent: 0"><FONT STYLE="font-family: Times New Roman, Times, Serif">&nbsp;</FONT></TD>
      <TD STYLE="padding: 0; font: 10pt Times New Roman, Times, Serif; vertical-align: top; text-align: center; text-indent: 0"><FONT STYLE="font-family: Times New Roman, Times, Serif">&nbsp;</FONT></TD></TR>
  <TR STYLE="font: 10pt Times New Roman, Times, Serif">
      <TD STYLE="border-bottom: Black 1.5pt solid; padding: 0; font: 10pt Times New Roman, Times, Serif; vertical-align: top; text-align: center; text-indent: 0"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">/s/
      Jamie Bechtel</FONT></TD>
      <TD STYLE="padding: 0; font: 10pt Times New Roman, Times, Serif; vertical-align: bottom; text-indent: 0"><FONT STYLE="font-family: Times New Roman, Times, Serif">&nbsp;</FONT></TD>
      <TD STYLE="padding: 0; font: 10pt Times New Roman, Times, Serif; vertical-align: top; text-align: center; text-indent: 0"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">Chair
      of the Board</FONT></TD></TR>
  <TR STYLE="font: 10pt Times New Roman, Times, Serif">
      <TD STYLE="padding: 0; font: 10pt Times New Roman, Times, Serif; vertical-align: top; text-align: center; text-indent: 0"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">Jamie
      Bechtel</FONT></TD>
      <TD STYLE="padding: 0; font: 10pt Times New Roman, Times, Serif; vertical-align: bottom; text-indent: 0"><FONT STYLE="font-family: Times New Roman, Times, Serif">&nbsp;</FONT></TD>
      <TD STYLE="padding: 0; font: 10pt Times New Roman, Times, Serif; vertical-align: top; text-align: center; text-indent: 0"><FONT STYLE="font-family: Times New Roman, Times, Serif">&nbsp;</FONT></TD></TR>
  <TR STYLE="font: 10pt Times New Roman, Times, Serif">
      <TD STYLE="padding: 0; font: 10pt Times New Roman, Times, Serif; vertical-align: top; text-align: center; text-indent: 0"><FONT STYLE="font-family: Times New Roman, Times, Serif">&nbsp;</FONT></TD>
      <TD STYLE="padding: 0; font: 10pt Times New Roman, Times, Serif; vertical-align: bottom; text-indent: 0"><FONT STYLE="font-family: Times New Roman, Times, Serif">&nbsp;</FONT></TD>
      <TD STYLE="padding: 0; font: 10pt Times New Roman, Times, Serif; vertical-align: top; text-align: center; text-indent: 0"><FONT STYLE="font-family: Times New Roman, Times, Serif">&nbsp;</FONT></TD></TR>
  <TR STYLE="font: 10pt Times New Roman, Times, Serif">
      <TD STYLE="border-bottom: Black 1.5pt solid; padding: 0; font: 10pt Times New Roman, Times, Serif; vertical-align: top; text-align: center; text-indent: 0"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">/s/
      Delphine Fran&ccedil;ois Chiavarini</FONT></TD>
      <TD STYLE="padding: 0; font: 10pt Times New Roman, Times, Serif; vertical-align: bottom; text-indent: 0"><FONT STYLE="font-family: Times New Roman, Times, Serif">&nbsp;</FONT></TD>
      <TD STYLE="padding: 0; font: 10pt Times New Roman, Times, Serif; vertical-align: top; text-align: center; text-indent: 0"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">Director</FONT></TD></TR>
  <TR STYLE="font: 10pt Times New Roman, Times, Serif">
      <TD STYLE="padding: 0; font: 10pt Times New Roman, Times, Serif; vertical-align: top; text-align: center; text-indent: 0"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">Delphine
      Fran&ccedil;ois Chiavarini </FONT></TD>
      <TD STYLE="padding: 0; font: 10pt Times New Roman, Times, Serif; vertical-align: bottom; text-indent: 0"><FONT STYLE="font-family: Times New Roman, Times, Serif">&nbsp;</FONT></TD>
      <TD STYLE="padding: 0; font: 10pt Times New Roman, Times, Serif; vertical-align: top; text-align: center; text-indent: 0"><FONT STYLE="font-family: Times New Roman, Times, Serif">&nbsp;</FONT></TD></TR>
  <TR STYLE="font: 10pt Times New Roman, Times, Serif">
      <TD STYLE="padding: 0; font: 10pt Times New Roman, Times, Serif; vertical-align: top; text-align: center; text-indent: 0"><FONT STYLE="font-family: Times New Roman, Times, Serif">&nbsp;</FONT></TD>
      <TD STYLE="padding: 0; font: 10pt Times New Roman, Times, Serif; vertical-align: bottom; text-indent: 0"><FONT STYLE="font-family: Times New Roman, Times, Serif">&nbsp;</FONT></TD>
      <TD STYLE="padding: 0; font: 10pt Times New Roman, Times, Serif; vertical-align: top; text-align: center; text-indent: 0"><FONT STYLE="font-family: Times New Roman, Times, Serif">&nbsp;</FONT></TD></TR>
  <TR STYLE="font: 10pt Times New Roman, Times, Serif">
      <TD STYLE="border-bottom: Black 1.5pt solid; padding: 0; font: 10pt Times New Roman, Times, Serif; vertical-align: top; text-align: center; text-indent: 0"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">/s/
      Marc Dumont</FONT></TD>
      <TD STYLE="padding: 0; font: 10pt Times New Roman, Times, Serif; vertical-align: bottom; text-indent: 0"><FONT STYLE="font-family: Times New Roman, Times, Serif">&nbsp;</FONT></TD>
      <TD STYLE="padding: 0; font: 10pt Times New Roman, Times, Serif; vertical-align: top; text-align: center; text-indent: 0"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">Director</FONT></TD></TR>
  <TR STYLE="font: 10pt Times New Roman, Times, Serif">
      <TD STYLE="padding: 0; font: 10pt Times New Roman, Times, Serif; vertical-align: top; text-align: center; text-indent: 0"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">Marc
      Dumont</FONT></TD>
      <TD STYLE="padding: 0; font: 10pt Times New Roman, Times, Serif; vertical-align: bottom; text-indent: 0"><FONT STYLE="font-family: Times New Roman, Times, Serif">&nbsp;</FONT></TD>
      <TD STYLE="padding: 0; font: 10pt Times New Roman, Times, Serif; vertical-align: top; text-align: center; text-indent: 0"><FONT STYLE="font-family: Times New Roman, Times, Serif">&nbsp;</FONT></TD></TR>
  <TR STYLE="font: 10pt Times New Roman, Times, Serif">
      <TD STYLE="padding: 0; font: 10pt Times New Roman, Times, Serif; vertical-align: top; text-align: center; text-indent: 0"><FONT STYLE="font-family: Times New Roman, Times, Serif">&nbsp;</FONT></TD>
      <TD STYLE="padding: 0; font: 10pt Times New Roman, Times, Serif; vertical-align: bottom; text-indent: 0"><FONT STYLE="font-family: Times New Roman, Times, Serif">&nbsp;</FONT></TD>
      <TD STYLE="padding: 0; font: 10pt Times New Roman, Times, Serif; vertical-align: top; text-align: center; text-indent: 0"><FONT STYLE="font-family: Times New Roman, Times, Serif">&nbsp;</FONT></TD></TR>
  <TR STYLE="font: 10pt Times New Roman, Times, Serif">
      <TD STYLE="border-bottom: Black 1.5pt solid; padding: 0; font: 10pt Times New Roman, Times, Serif; vertical-align: top; text-align: center; text-indent: 0"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">/s/
      Matthew K. Szot</FONT></TD>
      <TD STYLE="padding: 0; font: 10pt Times New Roman, Times, Serif; vertical-align: bottom; text-indent: 0"><FONT STYLE="font-family: Times New Roman, Times, Serif">&nbsp;</FONT></TD>
      <TD STYLE="padding: 0; font: 10pt Times New Roman, Times, Serif; vertical-align: top; text-align: center; text-indent: 0"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">Director</FONT></TD></TR>
  <TR STYLE="font: 10pt Times New Roman, Times, Serif">
      <TD STYLE="padding: 0; font: 10pt Times New Roman, Times, Serif; vertical-align: top; text-align: center; text-indent: 0"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">Matthew
      K. Szot</FONT></TD>
      <TD STYLE="padding: 0; font: 10pt Times New Roman, Times, Serif; vertical-align: bottom; text-indent: 0"><FONT STYLE="font-family: Times New Roman, Times, Serif">&nbsp;</FONT></TD>
      <TD STYLE="padding: 0; font: 10pt Times New Roman, Times, Serif; vertical-align: top; text-align: center; text-indent: 0"><FONT STYLE="font-family: Times New Roman, Times, Serif">&nbsp;</FONT></TD></TR>
  <TR STYLE="font: 10pt Times New Roman, Times, Serif">
      <TD STYLE="padding: 0; font: 10pt Times New Roman, Times, Serif; vertical-align: top; text-align: center; text-indent: 0"><FONT STYLE="font-family: Times New Roman, Times, Serif">&nbsp;</FONT></TD>
      <TD STYLE="padding: 0; font: 10pt Times New Roman, Times, Serif; vertical-align: bottom; text-indent: 0"><FONT STYLE="font-family: Times New Roman, Times, Serif">&nbsp;</FONT></TD>
      <TD STYLE="padding: 0; font: 10pt Times New Roman, Times, Serif; vertical-align: top; text-align: center; text-indent: 0"><FONT STYLE="font-family: Times New Roman, Times, Serif">&nbsp;</FONT></TD></TR>
  <TR STYLE="font: 10pt Times New Roman, Times, Serif">
      <TD STYLE="border-bottom: Black 1.5pt solid; padding: 0; font: 10pt Times New Roman, Times, Serif; vertical-align: top; text-align: center; text-indent: 0"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">/s/
      Julia Williams, M.D.</FONT></TD>
      <TD STYLE="padding: 0; font: 10pt Times New Roman, Times, Serif; vertical-align: bottom; text-indent: 0"><FONT STYLE="font-family: Times New Roman, Times, Serif">&nbsp;</FONT></TD>
      <TD ROWSPAN="2" STYLE="padding: 0; font: 10pt Times New Roman, Times, Serif; vertical-align: top; text-align: center; text-indent: 0"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">Director</FONT></TD></TR>
  <TR STYLE="font: 10pt Times New Roman, Times, Serif">
      <TD STYLE="font: 10pt Times New Roman, Times, Serif; padding: 0; vertical-align: top; text-align: center; text-indent: 0"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">Julia
      Williams, M.D.</FONT></TD>
      <TD STYLE="padding: 0; font: 10pt Times New Roman, Times, Serif; vertical-align: bottom; text-indent: 0"><FONT STYLE="font-family: Times New Roman, Times, Serif">&nbsp;</FONT></TD></TR>
  </TABLE>
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  <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center"><FONT STYLE="font-family: Times New Roman, Times, Serif">&nbsp;II-4</FONT></P>
  
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metadata_documents: [{"type": "S-8", "sequence": "1", "filename": "ea125527-s8_senestechinc.htm", "description": "REGISTRATION STATEMENT", "secsgml_size_bytes": 91930}]
metadata_filer: {"company-data": {"conformed-name": "SenesTech, Inc.", "cik": "0001680378", "assigned-sic": "2870", "irs-number": "202079805", "state-of-incorporation": "DE", "fiscal-year-end": "1231"}, "filing-values": {"form-type": "S-8", "act": "33", "file-number": "333-246258", "film-number": "201104039"}, "business-address": {"street1": "3140 N. CADEN COURT", "street2": "SUITE 1", "city": "FLAGSTAFF", "state": "AZ", "zip": "86004", "phone": "(928) 779 - 4143"}, "mail-address": {"street1": "3140 N. CADEN COURT", "street2": "SUITE 1", "city": "FLAGSTAFF", "state": "AZ", "zip": "86004"}}
text: As
  filed with the Securities and Exchange Commission on August 14, 2020
  Registration
  No. 333-
  UNITED
  STATES
  SECURITIES
  AND EXCHANGE COMMISSION
  Washington,
  D.C. 20549
  FORM S-8
  REGISTRATION
  STATEMENT
  UNDER
  THE
  SECURITIES ACT OF 1933
  SENESTECH,
  INC.
  (Exact name of registrant as specified in its charter)
  Delaware
  20-2079805
  (State
      or other jurisdiction of
  incorporation or organization)
  (I.R.S.
      Employer
  Identification No.)
  23460
  N. 19th Avenue, Suite 110
  Phoenix, AZ 85027
  (928) 779-4143
  (Address of Principal Executive Offices, including zip code)
  SENESTECH,
  INC. 2018 EQUITY INCENTIVE PLAN
  (Full title of the plan)
  Kenneth
  Siegel
  Chief
  Executive Officer
  SenesTech,
  Inc.
  23460
  N. 19th Avenue, Suite 110
  Phoenix, AZ 85027
  (928) 779-4143
  (Name,
  address, including zip code and telephone number, including area code, of agent for service)
  Copy
  to:
  Chris
  Hall
  Perkins Coie LLP
  1120 NW Couch Street, Tenth Floor
  Portland,
  Oregon 97209-4128
  (503)
  727-2000
  Indicate
  by check mark whether the registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, a smaller reporting
  company, or an emerging growth company. See the definitions of "large accelerated filer," "accelerated filer,"
  "smaller reporting company," and "emerging growth company" in Rule 12b-2 of the Exchange Act.
  Large
      accelerated filer  ☐
  Non-accelerated
      filer ☒
  Smaller
      reporting company ☒
  Accelerated
      filer           ☐
  Emerging
      growth company ☒
  If an
  emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying
  with any new or revised financial accounting standards provided pursuant to Section 7(a)(2)(B) of the Securities Act. ☒
  CALCULATION
  OF REGISTRATION FEE
  Title of Securities
      to Be Registered
  Amount to Be
      Registered (1)
  Proposed Maximum
      Offering Price Per Share (2)
  Proposed Maximum
      Aggregate Offering Price (2)
  Amount
      of Registration Fee (2)
  Common
      Stock, $0.001 par value, under the SenesTech, Inc. 2018 Equity Incentive Plan
  800,000 shares
  $
  2.02
  $
  1,616,000.00
  $
  209.76
  (1)
  Pursuant
                                           to Rule 416(c) under the Securities Act, includes an indeterminate number of additional
                                           shares which may be necessary to adjust the number of shares issued pursuant to the plan
                                           as the result of any future stock split, stock dividend or similar adjustment of our
                                           outstanding common stock.
  (2)
  Estimated
                                           solely for the purpose of calculating the registration fee pursuant to Rule 457 under
                                           the Securities Act of 1933, as amended. The Proposed Maximum Offering Price Per Share
                                           is estimated to be $2.02 based on the average of the high sale price ($2.11) and the
                                           low sale price ($1.92) for our common stock as reported by the Nasdaq Stock Market on
                                           August 11, 2020.
  PART II
  INFORMATION
  REQUIRED IN REGISTRATION STATEMENT
  Item
  3.
  INCORPORATION
                                           OF CERTAIN DOCUMENTS BY REFERENCE
  The
  following documents filed by SenesTech, Inc. (the "
  Registrant
  ") with the Securities and Exchange Commission
  (the "
  Commission
  ") are hereby incorporated by reference into this Registration Statement:
  (a)	The
  Registrant's Annual Report on
  Form 10-K
  for the year ended December 31, 2019, filed with the Commission on March 17,
  2020, as amended by
  Form 10-K/A
  , filed with the Commission on April 21, 2020;
  (b)	The
  Registrant's Quarterly Reports on Form 10-Q for the quarter ended
  March 31, 2020
  , filed with the Commission on May 15,
  2020, and for the quarter ended
  June 30, 2020
  , filed with the Commission on August 13, 2020;
  (c)
  The Registrant's Current Reports on Form 8-K, filed with the Commission on
  January
  28, 2020
  ,
  February
  4, 2020
  ,
  February 20,
  2020
  ,
  March 6, 2020
  ,
  April 21, 2020
  ,
  April 21, 2020
  ,
  April
  22, 2020
  ,
  April 24,
  2020
  and
  July 10,
  2020
  and the Registrant's Current Report on Form 8-K/A filed with the Commission on
  July
  14, 2020
  (excluding any reports, or portions thereof, deemed to have been furnished under Item 2.02 or Item 7.01 and any
  exhibits included with such Items); and
  (d)
  The description of the Registrant's common stock contained in the Registration Statement on
  Form 8-A
  (File No. 001-37941)
  filed with the Commission on November 7, 2016 under the Securities Exchange Act of 1934, as amended (the "
  Exchange Act
  "),
  including any amendment or report filed for the purpose of updating such description.
  All
  documents the Registrant files pursuant to Sections 13(a), 13(c), 14 and 15(d) of the Exchange Act after the date hereof
  (excluding any documents or portions of such documents that are furnished under Item 2.02 or Item 7.01 of a current report on
  Form 8-K and any exhibits included with such Items), and prior to the filing of a post-effective amendment which indicates that
  the securities offered hereby have been sold or which deregisters all securities covered hereby then remaining unsold, shall also
  be deemed to be incorporated by reference into this Registration Statement and to be a part hereof commencing on the respective
  dates on which such documents are filed.
  Item
  4.
  DESCRIPTION
                                           OF SECURITIES
  Not
  applicable.
  Item
  5.
  INTERESTS
                                           OF NAMED EXPERTS AND COUNSEL
  None.
  Item
  6.
  INDEMNIFICATION
                                           OF DIRECTORS AND OFFICERS
  The
  Registrant is incorporated under the laws of the State of Delaware. Section 145 of the Delaware General Corporation Law provides
  that a Delaware corporation may indemnify any persons who were, are, or are threatened to be made, parties to any threatened,
  pending or completed action, suit or proceeding, whether civil, criminal, administrative or investigative (other than an action
  by or in the right of such corporation), by reason of the fact that such person is or was an officer, director, employee or agent
  of such corporation, or is or was serving at the request of such corporation as an officer, director, employee or agent of another
  corporation, partnership, joint venture, trust or other enterprise. The indemnification may include expenses (including attorneys'
  fees), judgments, fines and amounts paid in settlement actually and reasonably incurred by such person in connection with defending
  or settling such action, suit or proceeding, provided that such person acted in good faith and in a manner he or she reasonably
  believed to be in or not opposed to the corporation's best interests except that no indemnification is permitted without
  judicial approval if the officer or director is adjudged to be liable to the corporation. Where an officer or director is successful
  on the merits or otherwise in the defense of any action referred to above, the corporation must indemnify him or her against the
  expenses (including attorneys' fees) actually and reasonably incurred.
  The
  Registrant's amended and restated certificate of incorporation, as amended, and amended and restated bylaws provide for
  the indemnification of its directors and officers to the fullest extent permitted under the Delaware General Corporation Law.
  II-
  1
  Section
  102(b)(7) of the Delaware General Corporation Law permits a corporation to provide in its certificate of incorporation that a
  director of the corporation shall not be personally liable to the corporation or its stockholders for monetary damages for breach
  of fiduciary duties as a director, except for liability for any:
  ●
  Breach
                                           of the director's duty of loyalty to the corporation or its stockholders;
  ●
  Act
                                           or omission not in good faith or that involves intentional misconduct or a knowing violation
                                           of law;
  ●
  Unlawful
                                           payment of dividends or unlawful stock purchase or redemption; or
  ●
  Transaction
                                           from which the director derives an improper personal benefit.
  The
  Registrant's amended and restated certificate of incorporation, as amended, includes such a provision. Expenses incurred
  by any officer or director in defending any such action, suit or proceeding in advance of its final disposition shall be paid
  by the Registrant upon delivery to it of an undertaking, by or on behalf of such director or officer, to repay all amounts so
  advanced if it shall ultimately be determined that such director or officer is not entitled to be indemnified by the Registrant.
  Section
  174 of the Delaware General Corporation Law provides, among other things, that a director who willfully or negligently approves
  an unlawful payment of dividends or an unlawful stock purchase or redemption, may be held jointly and severally liable for such
  actions. A director who was either absent when the unlawful actions were approved or dissented at the time may avoid liability
  by causing his or her dissent to such actions to be entered in the books containing minutes of the meetings of the board of directors
  at the time such action occurred or immediately after such absent director receives notice of the unlawful acts.
  As
  permitted by the Delaware General Corporation Law, the Registrant has entered into indemnification agreements with each of its
  directors and executive officers that require the Registrant to indemnify such persons against any and all costs and expenses
  (including attorneys', witness or other professional fees) actually and reasonably incurred by such persons in connection
  with any action, suit or proceeding (including derivative actions), whether actual or threatened, to which any such person may
  be made a party by reason of the fact that such person is or was a director or officer or is or was acting or serving as an officer,
  director, employee or agent of the Registrant or any of its affiliated enterprises. Under these agreements, the Registrant is
  not required to provide indemnification for certain matters, including:
  ●
  Indemnification
                                           for expenses or losses with respect to proceedings initiated by the director or officer,
                                           including any proceedings against the Registrant or its directors, officers, employees
                                           or other indemnitees and not by way of defense, with certain exceptions;
  ●
  Indemnification
                                           for any proceeding if a final decision by a court of competent jurisdiction determines
                                           that such indemnification is prohibited by applicable law;
  ●
  Indemnification
                                           for the disgorgement of profits arising from the purchase or sale by the director or
                                           officer of securities of the Registrant in violation of Section 16(b) of the Exchange
                                           Act, or any similar successor statute; or
  ●
  Indemnification
                                           for the director or officer's reimbursement to the Registrant of any bonus or other
                                           incentive-based or equity-based compensation previously received by the director or officer
                                           or payment of any profits realized by the director or officer from the sale of securities
                                           of the Registrant, as required in each case under the Exchange Act.
  The
  indemnification agreements also set forth certain procedures that will apply in the event of a claim for indemnification thereunder.
  The Registrant has an insurance policy in place, with limits of $20.0 million in the aggregate, that covers its officers and directors
  with respect to certain liabilities, including liabilities arising under the Securities Act of 1933, as amended (the "
  Securities
  Act
  ") or otherwise. Insofar as indemnification for liabilities arising under the Securities Act may be permitted to
  directors, officers and controlling persons of the Registrant pursuant to the foregoing provisions, or otherwise, the Registrant
  has been advised that in the opinion of the Commission such indemnification is against public policy as expressed in the Securities
  Act and is, therefore, unenforceable.
  Item
  7.
  EXEMPTIONS
                                           FROM REGISTRATION CLAIMED
  Not
  applicable.
  II-
  2
  Item 8.
  EXHIBITS
  Exhibit
      Number
  Description
  5.1+
  Opinion of Perkins Coie LLP regarding legality of the common stock being registered
  23.1+
  Consent of M&K CPAS, PLLC
  23.2+
  Consent of Perkins Coie LLP (included in opinion filed as Exhibit 5.1)
  24.1+
  Power of Attorney (see signature page)
  99.1*
  SenesTech,
      Inc. 2018 Equity Incentive Plan, as amended (incorporated by reference to Exhibit 10.3 to the Registrant's Quarterly
      Report on Form 10-Q filed with the Commission on August 13, 2020)
  +
  Filed
                                           herewith.
  *
  Incorporated
                                           herein by reference.
  Item
  9.
  UNDERTAKINGS
  A. The
  undersigned Registrant hereby undertakes:
  (1)
  To file, during any period in which offers or sales are being made, a post-effective amendment to this Registration Statement:
  (a)
  To include any prospectus required by Section 10(a)(3) of the Securities Act;
  (b)
  To reflect in the prospectus any facts or events arising after the effective date of this Registration Statement (or the most
  recent post-effective amendment thereof) which, individually or in the aggregate, represent a fundamental change in the information
  set forth in this Registration Statement; and
  (c)
  To include any material information with respect to the plan of distribution not previously disclosed in this Registration Statement
  or any material change to such information in this Registration Statement;
  provided
  ,
  however
  ,
  that paragraphs (1)(a) and (1)(b) above do not apply if the information required to be included in a post-effective
  amendment by those paragraphs is contained in reports filed with or furnished to the Commission by the Registrant pursuant to
  Section 13 or 15(d) of the Exchange Act that are incorporated by reference in this Registration Statement.
  (2)
  That, for the purpose of determining any liability under the Securities Act, each such post-effective amendment shall be deemed
  to be a new registration statement relating to the securities offered therein, and the offering of such securities at that time
  shall be deemed to be the initial bona fide offering thereof.
  (3)
  To remove from registration by means of a post-effective amendment any of the securities being registered which remain unsold
  at the termination of the offering.
  B. The
  undersigned Registrant hereby undertakes that, for purposes of determining any liability under the Securities Act, each filing
  of the Registrant's annual report pursuant to Section 13(a) or Section 15(d) of the Exchange Act (and, where
  applicable, each filing of an employee benefits plan's annual report pursuant to Section 15(d) of the Exchange
  Act) that is incorporated by reference in this Registration Statement shall be deemed to be a new registration statement relating
  to the securities offered therein, and the offering of such securities at that time shall be deemed to be the initial bona fide
  offering thereof.
  C. Insofar
  as indemnification for liabilities arising under the Securities Act may be permitted to directors, officers and controlling persons
  of the Registrant pursuant to the foregoing provisions, or otherwise, the Registrant has been advised that, in the opinion of
  the Commission, such indemnification is against public policy as expressed in the Securities Act and is, therefore, unenforceable.
  In the event that a claim for indemnification against such liabilities (other than the payment by the Registrant of expenses incurred
  or paid by a director, officer or controlling person of the Registrant in the successful defense of any action, suit or proceeding)
  is asserted by such director, officer or controlling person in connection with the securities being registered, the Registrant
  will, unless in the opinion of its counsel the matter has been settled by controlling precedent, submit to a court of appropriate
  jurisdiction the question whether such indemnification by it is against public policy as expressed in the Securities Act and will
  be governed by the final adjudication of such issue.
  II-
  3
  SIGNATURES
  Pursuant
  to the requirements of the Securities Act of 1933, the Registrant certifies that it has reasonable grounds to believe that it
  meets all the requirements for filing on Form S-8 and has duly caused this Registration Statement to be signed on its behalf
  by the undersigned, thereunto duly authorized, in the City of Phoenix, State of Arizona, on August 14, 2020.
  SENESTECH,
      INC.
  /s/
      Kenneth Siegel
  By:
  Kenneth Siegel
  Chief Executive
      Officer
  POWER
  OF ATTORNEY
  Each
  person whose signature appears below authorizes Kenneth Siegel and Thomas C. Chesterman, or either of them, as attorneys-in-fact
  with full power of substitution, to execute in the name and on the behalf of each person, individually and in each capacity stated
  below, and to file, any and all amendments to this Registration Statement, including any and all post-effective amendments.
  Pursuant
  to the requirements of the Securities Act of 1933, this Registration Statement has been signed by the following persons in the
  capacities indicated below on August 14, 2020.
  Signature
  Title
  /s/
      Kenneth Siegel
  Chief
      Executive Officer and Director
  Kenneth
      Siegel
  (Principal
      Executive Officer)
  /s/
      Thomas C. Chesterman
  Chief
      Financial Officer and Treasurer
  Thomas
      C. Chesterman
  (Principal
      Financial and Accounting Officer)
  /s/
      Jamie Bechtel
  Chair
      of the Board
  Jamie
      Bechtel
  /s/
      Delphine François Chiavarini
  Director
  Delphine
      François Chiavarini
  /s/
      Marc Dumont
  Director
  Marc
      Dumont
  /s/
      Matthew K. Szot
  Director
  Matthew
      K. Szot
  /s/
      Julia Williams, M.D.
  Director
  Julia
      Williams, M.D.
  II-4