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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>As filed with the Securities and Exchange
Commission on September 21, 2016</B></P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: right; border-bottom: Black 4.5pt double"><B>Registration
No. 333-&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</B></P>

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<P STYLE="font: 14pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>UNITED STATES</B></P>

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<P STYLE="font: 14pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>SECURITIES AND EXCHANGE COMMISSION</B></P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>Washington, D.C. 20549</B></P>

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<P STYLE="font: 14pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>FORM S-8</B></P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>REGISTRATION STATEMENT<BR>
UNDER THE SECURITIES ACT OF 1933</B></P>

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<P STYLE="font: 14pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>ADVANCED ACCELERATOR APPLICATIONS S.A.</B>&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>(Exact Name of Registrant as specified
in its charter)</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<table cellspacing="0" cellpadding="0" style="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
<tr style="vertical-align: top">
    <td style="width: 29%; text-align: center; font-size: 8pt; font-weight: bold">France</td>
    <td style="width: 40%; font-size: 10pt">&nbsp;</td>
    <td style="width: 31%; text-align: center; font-size: 8pt; font-weight: bold">N/A</td></tr>
<tr style="vertical-align: top">
    <td style="font-size: 10pt; text-align: center"><font style="font-size: 10pt">(State or other jurisdiction of </font><br>
<font style="font-size: 10pt">incorporation or organization)</font></td>
    <td style="font-size: 10pt">&nbsp;</td>
    <td style="font-size: 10pt; text-align: center"><font style="font-size: 10pt">(I.R.S. Employer </font><br>
<font style="font-size: 10pt">Identification No.)</font></td></tr>
<tr style="vertical-align: top">
    <td style="font-size: 10pt">&nbsp;</td>
    <td>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><b>20 rue Diesel</b></P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"></P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><b>01630 Saint Genis Pouilly, France</b></P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P></td>
    <td style="font-size: 10pt">&nbsp;</td></tr>
<tr style="vertical-align: top">
    <td colspan="3" style="font-size: 10pt; text-align: center"><font style="font-size: 8pt">(Address including zip code of Principal Executive Offices) </font></td></tr>
<tr style="vertical-align: top">
    <td style="font-size: 10pt">&nbsp;</td>
    <TD STYLE="text-align: center">
<IMG SRC="image_004.gif" ALT=""></td>
    <td style="font-size: 10pt">&nbsp;</td></tr>
<tr>
    <td colspan="3">
        <P STYLE="font: 8pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><b>Advanced Accelerator Applications S.A
        2016 Warrant Plan<br>
        Advanced Accelerator Applications S.A 2015 Stock Option Plan</b></P>
        <P STYLE="font: 8pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"></P>
        <P STYLE="font: 8pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><b>Advanced Accelerator Applications S.A.
        2013 Free Share Plan<br>
        Advanced Accelerator Applications S.A 2010 Free Share Plan</b></P>
        <P STYLE="font: 8pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"></P></td></tr>
<tr>
    <td style="vertical-align: top; font-size: 10pt">&nbsp;</td>
    <td style="font-size: 10pt; text-align: center"><font style="font-size: 8pt">(Full title of the plans)</font></td>
    <td style="vertical-align: top; font-size: 10pt">&nbsp;</td></tr>
<tr style="vertical-align: top">
    <td style="font-size: 10pt">&nbsp;</td>
    <TD STYLE="text-align: center">
<IMG SRC="image_004.gif" ALT=""></td>
    <td style="font-size: 10pt">&nbsp;</td></tr>
<tr style="vertical-align: top">
    <td colspan="3">
        <P STYLE="font: 8pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><b>Edward Sturchio<br>
        Global General Counsel</b></P>
        <P STYLE="font: 8pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"></P>
        <P STYLE="font: 8pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><b>Advanced Accelerator Applications S.A.</b></P>
        <P STYLE="font: 8pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"></P>
        <P STYLE="font: 8pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><b>The Empire State Building</b></P>
        <P STYLE="font: 8pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"></P>
        <P STYLE="font: 8pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><b>350 Fifth Avenue, Suite 6902</b></P>
        <P STYLE="font: 8pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"></P>
        <P STYLE="font: 8pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><b>New York, NY, 10118, USA </b></P>
</td></tr>
<tr style="vertical-align: top">
    <td style="font-size: 10pt">&nbsp;</td>
    <TD STYLE="text-align: center">
<IMG SRC="image_004.gif" ALT=""></td>
    <td style="font-size: 10pt">&nbsp;</td></tr>
<tr>
    <td colspan="3">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><b>National Registered Agents, Inc.<br clear="all">
        111 Eighth Avenue,<br>
        New York,<br>
        New York 10011<br>
        (888-579-0286)</b></P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"></P>
        <P STYLE="font: 8pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">(Name, address and telephone number, including
        area code, of agent for service)</P>
</td></tr>
<tr style="vertical-align: top">
    <td style="font-size: 10pt">&nbsp;</td>
    <TD STYLE="text-align: center">
<IMG SRC="image_004.gif" ALT=""></td>
    <td style="font-size: 10pt">&nbsp;</td></tr>
<tr style="vertical-align: top">
    <td style="font-size: 10pt">&nbsp;</td>
    <td>
        <P STYLE="font: 8pt Times New Roman, Times, Serif; margin: 0pt 0.5in; text-align: center"><B>Copies to</B>:&nbsp;</P></td>
    <td style="font-size: 10pt">&nbsp;</td></tr>
<tr style="vertical-align: top">
    <td style="font-size: 10pt">&nbsp;</td>
    <td>
        <P STYLE="font: 8pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center">John Crowley&nbsp;</P>
        <P STYLE="font: 8pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">Davis Polk &amp; Wardwell LLP</P>

        <P STYLE="font: 8pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">450 Lexington Avenue</P>

        <P STYLE="font: 8pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">New York, NY 10017</P>
</td>
    <td style="font-size: 10pt">&nbsp;</td></tr>
</table>
<P STYLE="font: 8pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><B>Indicate by check mark whether the registrant
is a large accelerated filer, an accelerated filer, a non-accelerated filer, or a smaller reporting company. See the definitions
of &ldquo;large accelerated filer,&rdquo; &ldquo;accelerated filer&rdquo; and &ldquo;smaller reporting company&rdquo; in Rule 12b-2
of the Exchange Act.</B></P>

<P STYLE="font: 8pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<table cellspacing="0" cellpadding="0" style="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
<tr style="vertical-align: top">
    <td style="width: 63%; font-size: 12pt"><font style="font-size: 8pt"><b>Large accelerated filer </b></font>&#9744;</td>
    <td style="width: 37%; font-size: 12pt"><font style="font-size: 8pt"><b>Accelerated filer </b></font>&#9744;</td></tr>
<tr style="vertical-align: top">
    <td style="font-size: 12pt"><FONT STYLE="font-size: 8pt"><B>Non-accelerated filer </B>&#9746;<B>&nbsp;(Do not check if a smaller
reporting company)</B></FONT></td>
    <td style="font-size: 12pt"><font style="font-size: 8pt"><b>Smaller reporting company </b></font>&#9744;</td></tr>
</table>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>&nbsp;</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"></P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>&nbsp;</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>&nbsp;</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>CALCULATION OF REGISTRATION FEE</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<table cellspacing="0" cellpadding="0" style="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
<tr style="vertical-align: bottom">
    <td style="width: 40%; border-top: black 2.25pt double; border-right: black 1pt solid; border-bottom: black 1pt solid; text-align: center; font-size: 8pt; font-weight: bold"><font style="font-size: 10pt">Title of Securities to be Registered</font></td>
    <td style="width: 14%; border-top: black 2.25pt double; border-right: black 1pt solid; border-bottom: black 1pt solid; text-align: center; font-size: 8pt; font-weight: bold"><font style="font-size: 10pt">Amount to be<font style="font-weight: normal"> </font>Registered<sup>(1)</sup></font></td>
    <td style="width: 15%; border-top: black 2.25pt double; border-right: black 1pt solid; border-bottom: black 1pt solid; text-align: center; font-size: 8pt; font-weight: bold"><font style="font-size: 10pt">Proposed Maximum Offering Price Per&nbsp;Share<sup>(2)</sup></font></td>
    <td style="width: 18%; border-top: black 2.25pt double; border-right: black 1pt solid; border-bottom: black 1pt solid; text-align: center; font-size: 8pt; font-weight: bold"><font style="font-size: 10pt">Proposed Maximum&nbsp;&nbsp;Aggregate<font style="font-weight: normal"> </font>Offering&nbsp;Price </font></td>
    <td style="width: 13%; border-top: black 2.25pt double; border-bottom: black 1pt solid; text-align: center; font-size: 8pt; font-weight: bold"><font style="font-size: 10pt">Amount of<font style="font-weight: normal"> </font>Registration Fee<sup>(3) </sup></font></td></tr>
<tr style="vertical-align: bottom">
    <td style="border-right: black 1pt solid; border-bottom: black 1pt solid; font-size: 10pt">Ordinary Shares, par value &euro;0.10 each, reserved for issuance pursuant to the Advanced Accelerator Applications S.A. 2016 Warrant Plan<sup>(4)</sup></td>
    <td style="border-right: black 1pt solid; border-bottom: black 1pt solid; font-size: 10pt; text-align: center"><font style="font-size: 10pt">149,800</font></td>
    <td style="border-right: black 1pt solid; border-bottom: black 1pt solid; font-size: 12pt; text-align: center"><font style="font-size: 10pt">$17.11</font></td>
    <td style="border-right: black 1pt solid; border-bottom: black 1pt solid; font-size: 12pt; text-align: center"><font style="font-size: 10pt">$2,563,078.00</font></td>
    <td style="border-bottom: black 1pt solid; font-size: 12pt; text-align: center"><font style="font-size: 10pt">258.10</font></td></tr>
<tr style="vertical-align: bottom">
    <td style="border-right: black 1pt solid; border-bottom: black 1pt solid; font-size: 10pt">Ordinary Shares, par value &euro;0.10 each, reserved for issuance pursuant to the Advanced Accelerator Applications S.A. 2015 Stock Option Plan<sup>(4)</sup></td>
    <td style="border-right: black 1pt solid; border-bottom: black 1pt solid; font-size: 10pt; text-align: center"><font style="font-size: 10pt">12,204,561</font></td>
    <td style="border-right: black 1pt solid; border-bottom: black 1pt solid; font-size: 12pt; text-align: center"><font style="font-size: 10pt">$17.11</font></td>
    <td style="border-right: black 1pt solid; border-bottom: black 1pt solid; font-size: 12pt; text-align: center"><font style="font-size: 10pt">$208,820,038.71</font></td>
    <td style="border-bottom: black 1pt solid; font-size: 12pt; text-align: center"><font style="font-size: 10pt">21,028.18</font></td></tr>
<tr style="vertical-align: bottom">
    <td style="border-right: black 1pt solid; border-bottom: black 1pt solid; font-size: 10pt">Ordinary Shares, par value &euro;0.10&nbsp;&nbsp;each, reserved for issuance pursuant to the Advanced Accelerator Applications S.A. 2013 Free Share Plan<sup>(4)</sup> </td>
    <td style="border-right: black 1pt solid; border-bottom: black 1pt solid; font-size: 10pt; text-align: center"><font style="font-size: 10pt">500,000</font></td>
    <td style="border-right: black 1pt solid; border-bottom: black 1pt solid; font-size: 12pt; text-align: center"><font style="font-size: 10pt">$17.11</font></td>
    <td style="border-right: black 1pt solid; border-bottom: black 1pt solid; font-size: 12pt; text-align: center"><font style="font-size: 10pt">8,555,000.00</font></td>
    <td style="border-bottom: black 1pt solid; font-size: 12pt; text-align: center"><font style="font-size: 10pt">861.49</font></td></tr>
<tr style="vertical-align: bottom">
    <td style="border-right: black 1pt solid; border-bottom: black 1pt solid; font-size: 10pt">Ordinary Shares, par value &euro;0.10 each, reserved for issuance pursuant to the Advanced Accelerator Applications S.A. 2010 Free Share Plan<sup>(4)</sup> </td>
    <td style="border-right: black 1pt solid; border-bottom: black 1pt solid; font-size: 10pt; text-align: center"><font style="font-size: 10pt">547,500</font></td>
    <td style="border-right: black 1pt solid; border-bottom: black 1pt solid; font-size: 12pt; text-align: center"><font style="font-size: 10pt">$17.11</font></td>
    <td style="border-right: black 1pt solid; border-bottom: black 1pt solid; font-size: 12pt; text-align: center"><font style="font-size: 10pt">9,367,725.00</font></td>
    <td style="border-bottom: black 1pt solid; font-size: 12pt; text-align: center"><font style="font-size: 10pt">943.33</font></td></tr>
<tr style="vertical-align: bottom">
    <td style="border-right: black 1pt solid; border-bottom: black 1pt solid; font-size: 10pt"><b>Total Ordinary Shares</b></td>
    <td style="border-right: black 1pt solid; border-bottom: black 1pt solid; font-size: 10pt; text-align: center"><font style="font-size: 10pt">13,401,861</font></td>
    <td style="border-right: black 1pt solid; border-bottom: black 1pt solid; font-size: 12pt; text-align: center"><font style="font-size: 10pt">$17.11</font></td>
    <td style="border-right: black 1pt solid; border-bottom: black 1pt solid; font-size: 12pt; text-align: center"><font style="font-size: 10pt">229,305,841.71</font></td>
    <td style="border-bottom: black 1pt solid; font-size: 12pt; text-align: center"><font style="font-size: 10pt">23,091.10</font></td></tr>
</table>

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<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 8pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0"></TD><TD STYLE="width: 0.25in">(1)</TD><TD>This Registration Statement on Form S-8 (this &ldquo;Registration Statement&rdquo;) covers ordinary shares of &euro;0.10 each
par value (&ldquo;Ordinary Shares&rdquo;), of Advanced Accelerator Applications S.A. (the &ldquo;Registrant&rdquo;) issuable pursuant
to the plans set forth in this table (collectively, the &ldquo;Plans&rdquo;). Pursuant to Rule 416(a) under the Securities Act
of 1933, as amended (the &ldquo;Securities Act&rdquo;), this Registration Statement shall also cover any additional Ordinary Shares
that become issuable under the Plans by reason of any share dividend, share split or other similar transaction.</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 8pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="font: 8pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0in"></TD><TD STYLE="width: 0.25in; text-align: left">(2)</TD><TD>Computed solely for the purpose of calculating the registration
fee pursuant to Rule 457(c) and 457(h) under the Securities Act on the basis of the average high and low sale price on the NASDAQ
Global Select Market on September 14, 2016.</TD>
</TR></TABLE>

<P STYLE="font: 8pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.25in; text-indent: -0.25in">&nbsp;</P>

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<TD STYLE="width: 0"></TD><TD STYLE="width: 0.25in">(3)</TD><TD>Rounded up to the nearest penny.</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 8pt Times New Roman, Times, Serif">&nbsp;</P>

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<TD STYLE="width: 0"></TD><TD STYLE="width: 0.25in">(4)</TD><TD>The Ordinary Shares being registered hereby may be represented by the Registrant&rsquo;s American Depositary Shares, evidenced
by American Depositary Receipts. One of the Registrant&rsquo;s American Depositary Shares corresponds to two Ordinary Shares.</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 8pt Times New Roman, Times, Serif">&nbsp;</P>


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<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; text-indent: 0.25in">PART I</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; text-indent: 0.25in">INFORMATION REQUIRED
IN THE SECTION 10(a) PROSPECTUS</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">The documents containing the information
specified in Item 1 and Item 2 of Part I of Form S-8 will be sent or given to participants as specified by Rule 428(b)(1) under
the Securities Act. In accordance with the rules and regulations of the U.S. Securities and Exchange Commission (the &ldquo;Commission&rdquo;)
and the instructions to Form S-8, such documents are not being filed with the Commission either as part of this Registration Statement
or as prospectuses or prospectus supplements pursuant to Rule 424 under the Securities Act.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; text-indent: 0.25in">PART II</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; text-indent: 0.25in">INFORMATION REQUIRED
IN THE REGISTRATION STATEMENT</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">Item 3. Incorporation of Documents by Reference.</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0in">The following documents are incorporated herein
by reference:</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0in">(a) The Registrant&rsquo;s Annual Report on
Form 20-F for the fiscal year ended December 31, 2015 and filed on April 29, 2016.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0in">(b) All other reports filed by the Registrant
pursuant to Sections 13(a) or 15(d) of the Exchange Act since the end of the fiscal year covered by the Annual Report on Form 20-F
referred to in Item 3(a) above.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0in">(c) The description of the Registrant&rsquo;s
American Depositary Shares evidenced by American Depositary Receipts, each representing two Ordinary Shares, and Ordinary Shares
contained in the Registrant&rsquo;s Registration Statement on Form F-1/A dated November 2, 2015, filed under the Exchange Act,
including any amendment thereto or report filed for the purpose of updating such description.&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0in">In addition, all documents subsequently filed
by the Registrant with the Commission pursuant to Sections 13(a), 13(c), 14 and 15(d) of the Exchange Act, prior to the filing
of a post-effective amendment to this Registration Statement which indicates that all securities offered have been sold or which
deregisters all securities then remaining unsold, including any Reports of Foreign Private Issuers on Form 6-K submitted during
such period (or portion thereof) that is identified in such form as being incorporated by reference into this Registration Statement,
shall be deemed to be incorporated by reference in this Registration Statement and to be a part hereof from the date of the filing
of such documents. The Registrant is not incorporating by reference any documents or portions thereof, whether specifically listed
above or filed in the future, that are not deemed &ldquo;filed&rdquo; with the Commission.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0in">Any statement contained in a document incorporated
or deemed to be incorporated by reference herein shall be deemed to be modified or superseded for purposes of this Registration
Statement to the extent that a statement contained herein, (or in any other subsequently filed document which also is incorporated
or deemed to be incorporated by reference herein), modifies or supersedes such statement. Any such statement so modified or superseded
shall not be deemed, except as so modified or superseded, to constitute a part of this Registration Statement.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0in">&nbsp;</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">Item 4. Description of Securities.</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0in">Not applicable, see Item 3(c).</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0in">&nbsp;</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">Item 5. Interests of Named Experts and Counsel.</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><FONT STYLE="font-weight: normal">Mr. Edward Sturchio, who is
giving an opinion on the validity of the securities being registered, is Global General Counsel for the Company and may hold equity
interest in the Company from time to time. </FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">Item 6. Indemnification of Directors and Officers.</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Under French law, provisions of by-laws that limit the liability
of directors are prohibited. However, French law allows <I>soci&eacute;t&eacute;s anonymes </I>to contract for and maintain liability
insurance against civil liabilities incurred by any of their directors and officers involved in a third-party action, provided
that they acted in good faith and within their</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>


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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">capacities as directors or officers of the company. Criminal
liability cannot be indemnified under French law, whether directly by the company or through liability insurance.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">We maintain liability insurance for our directors and officers,
including insurance against liability under the Securities Act of 1933, as amended, and we may enter into agreements with our directors
and executive officers to provide contractual indemnification.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">With certain exceptions and subject to limitations on indemnification
under French law, these agreements provide for indemnification for damages and expenses including, among other things, attorneys&rsquo;
fees, judgments, fines and settlement amounts incurred by any of these individuals in any action or proceeding arising out of his
or her actions in that capacity. We believe that this insurance and these agreements are necessary to attract and maintain qualified
directors and executive officers.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">These agreements may discourage shareholders from bringing a
lawsuit against our directors and executive officers for breach of their fiduciary duty. These provisions also may have the effect
of reducing the likelihood of derivative litigation against directors and executive officers, even though such an action, if successful,
might otherwise benefit us and our shareholders. Furthermore, a shareholder&rsquo;s investment may be adversely affected to the
extent we pay the costs of settlement and damage awards against directors and officers pursuant to these insurance agreements.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Certain of our non-employee directors may, through their relationships
with their employers or partnerships, be insured against certain liabilities in their capacity as members of our board of direc<FONT STYLE="font-family: Times New Roman, Times, Serif">tors.</FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">Item 7. Exemption from Registration Claimed.</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">Not applicable.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">Item 8. Exhibits.</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0"></P>

<TABLE CELLSPACING="0" CELLPADDING="5" STYLE="width: 100%; font: 10pt Times New Roman, Times, Serif; border-collapse: collapse">
<TR STYLE="vertical-align: top">
    <TD STYLE="width: 9%">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; border-bottom: Black 0.5pt solid">Exhibit Number&nbsp;</P></TD>
    <TD STYLE="width: 91%">&nbsp;</TD></TR>
<TR>
    <TD STYLE="vertical-align: top"><FONT STYLE="font-size: 10pt">4.1</FONT></TD>
    <TD STYLE="vertical-align: bottom; font-size: 10pt"><FONT STYLE="font-size: 10pt">English Translation of Advanced Acceleration Applications S.A. Articles of Association (incorporated herein by reference to the annual report on Form 20-F, filed on April 29, 2016)</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD><FONT STYLE="font-size: 10pt">4.2</FONT></TD>
    <TD><FONT STYLE="font-size: 10pt">Form of Deposit Agreement among Advanced Accelerator Applications S.A., The Bank of New York Mellon, as depositary, and owners and holders of American Depositary Shares (incorporated by reference to our Registration Statement on Form F-6 (File No. 333-201502) filed with the SEC on January 14, 2015)</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD><FONT STYLE="font-size: 10pt">4.3</FONT></TD>
    <TD><FONT STYLE="font-size: 10pt">Form of American Depositary Receipt (included in Exhibit 4.2)</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD><FONT STYLE="font-size: 10pt">5</FONT></TD>
    <TD><FONT STYLE="font-size: 10pt">Opinion of Edward Sturchio, counsel of Advanced Accelerator Applications S.A. (filed herewith)</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD><FONT STYLE="font-size: 10pt">23.1</FONT></TD>
    <TD><FONT STYLE="font-size: 10pt">Consent of Edward Sturchio, counsel of Advanced Accelerator Applications S.A. (included in Exhibit 5)</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD><FONT STYLE="font-size: 10pt">23.2</FONT></TD>
    <TD><FONT STYLE="font-size: 10pt">Consent of KPMG Audit, independent registered public accounting firm (filed herewith)</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD><FONT STYLE="font-size: 10pt">24</FONT></TD>
    <TD><FONT STYLE="font-size: 10pt">Powers of Attorney (included in the signature pages hereto)</FONT></TD></TR>
<TR>
    <TD STYLE="vertical-align: top"><FONT STYLE="font-size: 10pt">99.1</FONT></TD>
    <TD STYLE="vertical-align: bottom; font-size: 10pt"><FONT STYLE="font-size: 10pt">Advanced Accelerator Applications S.A. 2016 Warrant Plan</FONT></TD></TR>
<TR>
    <TD STYLE="vertical-align: top"><FONT STYLE="font-size: 10pt">99.2</FONT></TD>
    <TD STYLE="vertical-align: bottom"><FONT STYLE="font-size: 10pt">Advanced Accelerator Applications S.A. 2015 Stock Option Plan (incorporated herein by reference to Exhibit 10.11 to the Company&rsquo;s Registration Statement on Form F-1 (File No. 333-207223) filed with the SEC on October 1, 2015)</FONT></TD></TR>
<TR>
    <TD STYLE="vertical-align: top"><FONT STYLE="font-size: 10pt">99.3</FONT></TD>
    <TD STYLE="vertical-align: bottom; font-size: 10pt"><FONT STYLE="font-size: 10pt">Advanced Accelerator Applications S.A. 2013 Free Share Plan</FONT></TD></TR>
</TABLE>


<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0"></P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>


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<TABLE CELLSPACING="0" CELLPADDING="5" STYLE="width: 100%; font: 10pt Times New Roman, Times, Serif; border-collapse: collapse">
<tr>
    <TD STYLE="vertical-align: top; width: 9%; font-size: 12pt"><font style="font-size: 10pt">99.4</font></td>
    <TD STYLE="vertical-align: bottom; width: 91%; font-size: 10pt"><font style="font-size: 10pt">Advanced Accelerator Applications S.A. 2010 Free Share Plan</font></td></tr>
</table>
<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">Item 9. Undertakings.</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">(a)&#9;&nbsp;&nbsp;&nbsp;The undersigned Registrant hereby
undertakes:</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.25in; text-indent: 0.25in">(1)&#9;&nbsp;&nbsp;&nbsp;To file, during any period
in which offers or sales are being made, a post-effective amendment to this Registration Statement:</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.25in; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in; text-indent: 0.25in">(i)&#9;&nbsp;&nbsp;&nbsp;To include any prospectus
required by Section 10(a)(3) of the Securities Act;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in; text-indent: 0.25in">(ii)&#9;&nbsp;&nbsp;&nbsp;To reflect in the prospectus
any facts or events arising after the effective date of this Registration Statement (or the most recent post-effective amendment
thereof) which, individually or in the aggregate, represent a fundamental change in the information set forth in this Registration
Statement. Notwithstanding the foregoing, any increase or decrease in volume of securities offered (if the total dollar value of
securities offered would not exceed that which was registered) and any deviation from the low or high end of the estimated maximum
offering range may be reflected in the form of prospectus filed with the Commission pursuant to Rule&nbsp;424(b)&nbsp;if, in the
aggregate, the changes in volume and price represent no more than a 20 percent change in the maximum aggregate offering price set
forth in the &ldquo;Calculation of Registration Fee&rdquo; table in the effective Registration Statement;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in; text-indent: 0.25in">(iii)&#9;&nbsp;&nbsp;&nbsp;To include any material
information with respect to the Plans not previously disclosed in this Registration Statement or any material change to such information
in this Registration Statement;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.25in; text-indent: 0in"><I>provided</I>, <I>however</I>,
that paragraphs (a)(1)(i) and (a)(1)(ii) do not apply if the information required to be included in a post-effective amendment
by those paragraphs is contained in periodic reports filed with or furnished to the Commission by the Registrant pursuant to Section
13 or 15(d) of the Exchange Act that are incorporated by reference in this Registration Statement.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.25in; text-indent: 0in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.25in; text-indent: 0.25in">(2)&#9;&nbsp;&nbsp;&nbsp;That, for the purpose
of determining any liability under the Securities Act, each such post-effective amendment shall be deemed to be a new registration
statement relating to the securities offered therein, and the offering of such securities at that time shall be deemed to be the
initial <I>bona fide</I> offering thereof.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.25in; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.25in; text-indent: 0.25in">(3)&#9;&nbsp;&nbsp;&nbsp;To remove from registration
by means of a post-effective amendment any of the securities being registered which remain unsold at the termination of the offering.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.25in; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">(b)&#9;&nbsp;&nbsp;&nbsp;The undersigned Registrant hereby
undertakes that, for purposes of determining any liability under the Securities Act, each filing of the Registrant&rsquo;s annual
report pursuant to Section 13(a) or 15(d) of the Exchange Act (and, where applicable, each filing of an employee benefit plan&rsquo;s
annual report pursuant to Section 15(d) of the Exchange Act) that is incorporated by reference in this Registration Statement shall
be deemed to be a new registration statement relating to the securities offered therein, and the offering of such securities at
that time shall be deemed to be the initial <I>bona fide</I> offering thereof.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">(c)&#9;&nbsp;&nbsp;&nbsp;Insofar as indemnification for liabilities
arising under the Securities Act may be permitted to directors, officers and controlling persons of the Registrant pursuant to
the foregoing provisions, or otherwise, the Registrant has been advised that in the opinion of the Commission such indemnification
is against public policy as expressed in the Securities Act and is, therefore, unenforceable. In the event that a claim for indemnification
against such liabilities (other than the payment by the Registrant of expenses incurred or paid by a director, officer or controlling
person of the Registrant in the successful defense of any action, suit or proceeding) is asserted by such director, officer or
controlling person in connection with the securities being registered, the Registrant will, unless in the opinion of its counsel
the matter has been settled by controlling precedent, submit to a court of appropriate jurisdiction the question whether such indemnification
by it is against public policy as expressed in the Securities Act and will be governed by the final adjudication of such issue.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>


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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; text-indent: 0in"><B>SIGNATURES</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; text-indent: 0in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">Pursuant to the requirements of the Securities
Act, the Registrant certifies that it has reasonable grounds to believe that it meets all of the requirements for filing this
Registration Statement and has duly caused this Registration Statement to be signed on its behalf by the undersigned, thereunto
duly authorized, in the City of Saint Genis Pouilly, France, on this 21<SUP>st</SUP> day of September, 2016.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" ALIGN="RIGHT" STYLE="font: 10pt Times New Roman, Times, Serif; width: 40%; border-collapse: collapse">
<tr style="vertical-align: top">
    <td colspan="2" style="font-size: 10pt"><P STYLE="margin-top: 0; margin-bottom: 0">Advanced Accelerator Applications S.A.</P>
                                            <P STYLE="margin-top: 0; margin-bottom: 0">&nbsp;</P>
                                            <P STYLE="margin-top: 0; margin-bottom: 0">&nbsp;</P>
                                            <P STYLE="margin-top: 0; margin-bottom: 0">&nbsp;</P></td></tr>
<tr style="vertical-align: top">
    <TD STYLE="width: 18%; font-size: 10pt">By:</td>
    <TD STYLE="width: 82%; border-bottom: Black 1pt solid; font-size: 10pt">/s/Heinz M&auml;usli</td></tr>
<tr style="vertical-align: top">
    <td style="font-size: 10pt">Name:</td>
    <td style="font-size: 10pt">Heinz M&auml;usli</td></tr>
<tr style="vertical-align: top">
    <td style="font-size: 10pt">Title:</td>
    <td style="font-size: 10pt"><P STYLE="margin-top: 0; margin-bottom: 0">Chief Financial Officer</P>
                                <P STYLE="margin-top: 0; margin-bottom: 0">&nbsp;</P>
                                <P STYLE="margin-top: 0; margin-bottom: 0">&nbsp;</P>
                                <P STYLE="margin-top: 0; margin-bottom: 0">&nbsp;</P></td></tr>
<tr style="vertical-align: top">
    <td style="font-size: 10pt">&nbsp;</td>
    <td style="font-size: 10pt">&nbsp;</td></tr>
<tr style="vertical-align: top">
    <td colspan="2">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Advanced Accelerator Applications USA, Inc.<br>
        (Authorized Representative in the United States)</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P></td></tr>
<tr style="vertical-align: top">
    <td style="font-size: 10pt">By:</td>
    <td style="border-bottom: Black 1pt solid; font-size: 10pt">/s/ Edward A. Sturchio</td></tr>
<tr style="vertical-align: top">
    <td style="font-size: 10pt">Name:</td>
    <td style="font-size: 10pt">Edward A. Sturchio</td></tr>
<tr style="vertical-align: top">
    <td style="font-size: 10pt">Title:</td>
    <td style="font-size: 10pt">Global General Counsel</td></tr>
</table><BR STYLE="clear: both">

<!-- Field: Page; Sequence: 6 -->
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    <DIV STYLE="page-break-before: always; margin-top: 6pt; margin-bottom: 6pt"><P STYLE="margin: 0pt">&nbsp;</P></DIV>
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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>POWER OF ATTORNEY</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 42.85pt; background-color: white">KNOW ALL PERSONS
BY THESE PRESENTS, that each person whose signature appears below constitutes and appoints Stefano Buono, Heinz M&auml;usli, Jordan
Silverstein and Edward Sturchio, as his or her true and lawful attorneys-in-fact and agent, with full power of substitution and
resubstitution, for him or her and in his or her name, place and stead, in any and all capacities, to sign any and all amendments
(including post-effective amendments) to this Registration Statement and any and all additional registration statements pursuant
to Rule&nbsp;462(b) of the Securities Act of 1933, as amended, and to file the same, with all exhibits thereto, and all other documents
in connection therewith, with the U.S. Securities and Exchange Commission, granting unto said attorneys-in-fact and agent full
power and authority to do and perform each and every act in person, hereby ratifying and confirming all that said attorney-in-fact
and agent or his substitutes may lawfully do or cause to be done by virtue hereof.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 42.85pt; background-color: white">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 42.85pt; background-color: white">Pursuant to the
requirements of the Securities Act of 1933, as amended, this Registration Statement has been signed by the following persons in
the capacities and on the dates indicated.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 42.85pt; background-color: white">&nbsp;</P>

<table cellspacing="0" cellpadding="0" style="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
<tr>
    <td style="vertical-align: bottom; width: 28%; text-decoration: underline; text-align: center; font-size: 8pt; font-weight: bold"><font style="font-size: 10pt"><u>Signature</u></font></td>
    <td style="vertical-align: top; width: 1%; text-align: center; font-size: 8pt; font-weight: bold">&nbsp;</td>
    <td style="vertical-align: top; width: 47%; text-decoration: underline; text-align: center; font-size: 8pt; font-weight: bold"><font style="font-size: 10pt"><u>Title</u></font></td>
    <td style="vertical-align: top; width: 24%; text-decoration: underline; text-align: center; font-size: 8pt; font-weight: bold"><font style="font-size: 10pt"><u>Date</u></font></td></tr>
<tr>
    <td style="vertical-align: bottom; border-bottom: Black 1pt solid">/s/ Stefano Buono</td>
    <td style="vertical-align: top">&nbsp;</td>
    <td style="vertical-align: bottom; font-size: 12pt; text-align: center"><font style="font-size: 10pt">Chief Executive Officer, Director </font></td>
    <td style="vertical-align: bottom; text-align: center">September 21, 2016</td></tr>
<tr>
    <td style="vertical-align: bottom">Stefano Buono</td>
    <td style="vertical-align: top">&nbsp;</td>
    <td style="vertical-align: bottom; text-align: center">(Principal Executive Officer)</td>
    <td style="vertical-align: bottom; text-align: center">&nbsp;</td></tr>
<TR>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: top">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; text-align: center">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; text-align: center">&nbsp;</TD></TR>
<TR>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: top">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; text-align: center">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; text-align: center">&nbsp;</TD></TR>
<tr>
    <td style="vertical-align: bottom">/s/ Heinz M&auml;usli</td>
    <td style="vertical-align: top">&nbsp;</td>
    <td style="vertical-align: bottom; font-size: 12pt; text-align: center"><font style="font-size: 10pt">Chief Financial Officer</font></td>
    <td style="vertical-align: bottom; text-align: center">September 21, 2016</td></tr>
<tr>
    <TD STYLE="vertical-align: bottom; border-top: Black 1pt solid">Heinz M&auml;usli</td>
    <td style="vertical-align: top">&nbsp;</td>
    <td style="vertical-align: bottom; text-align: center">&nbsp;(Principal&nbsp;Financial and Accounting Officer)</td>
    <td style="vertical-align: bottom; text-align: center">&nbsp;</td></tr>
<TR>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: top">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; text-align: center">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; text-align: center">&nbsp;</TD></TR>
<tr>
    <td style="vertical-align: bottom">/s/ Claudio Costamagna</td>
    <td style="vertical-align: top">&nbsp;</td>
    <td style="vertical-align: bottom; text-align: center">Director</td>
    <td style="vertical-align: bottom; text-align: center">September 21, 2016</td></tr>
<tr>
    <td style="vertical-align: bottom; border-top: Black 1pt solid">Claudio Costamagna</td>
    <td style="vertical-align: top">&nbsp;</td>
    <td style="vertical-align: bottom; text-align: center">&nbsp;</td>
    <td style="vertical-align: bottom; text-align: center">&nbsp;</td></tr>
<TR>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: top">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; text-align: center">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; text-align: center">&nbsp;</TD></TR>
<tr>
    <td style="vertical-align: bottom; border-bottom: Black 1pt solid">/s/ Kapil Dhingra</td>
    <td style="vertical-align: top">&nbsp;</td>
    <td style="vertical-align: bottom; text-align: center">Director</td>
    <td style="vertical-align: bottom; text-align: center">September 19, 2016</td></tr>
<tr>
    <td style="vertical-align: bottom">Kapil Dhingra</td>
    <td style="vertical-align: top">&nbsp;</td>
    <td style="vertical-align: bottom; text-align: center">&nbsp;</td>
    <td style="vertical-align: bottom; text-align: center">&nbsp;</td></tr>
<TR>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: top">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; text-align: center">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; text-align: center">&nbsp;</TD></TR>
<tr>
    <TD STYLE="vertical-align: bottom; border-bottom: Black 1pt solid; text-align: left">/s/ <FONT STYLE="font-size: 10pt">Steve
    Gannon</FONT></td>
    <td style="vertical-align: top">&nbsp;</td>
    <td style="vertical-align: bottom; text-align: center">Director</td>
    <td style="vertical-align: bottom; text-align: center">September 21, 2016</td></tr>
<tr>
    <td style="vertical-align: bottom; font-size: 12pt"><font style="font-size: 10pt">Steve Gannon</font></td>
    <td style="vertical-align: top">&nbsp;</td>
    <td style="vertical-align: bottom; text-align: center">&nbsp;</td>
    <td style="vertical-align: bottom; text-align: center">&nbsp;</td></tr>
<TR>
    <TD STYLE="vertical-align: bottom; font-size: 12pt">&nbsp;</TD>
    <TD STYLE="vertical-align: top">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; text-align: center">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; text-align: center">&nbsp;</TD></TR>
<tr>
    <td style="vertical-align: bottom; border-bottom: Black 1pt solid">/s/ <FONT STYLE="font-size: 10pt">Yvonne Greenstreet</td>
    <td style="vertical-align: top">&nbsp;</td>
    <td style="vertical-align: bottom; text-align: center">Director</td>
    <td style="vertical-align: bottom; text-align: center">September 21, 2016</td></tr>
<tr>
    <td style="vertical-align: bottom; font-size: 12pt"><font style="font-size: 10pt">Yvonne Greenstreet</font></td>
    <td style="vertical-align: top">&nbsp;</td>
    <td style="vertical-align: bottom; text-align: center">&nbsp;</td>
    <td style="vertical-align: bottom; text-align: center">&nbsp;</td></tr>
<TR>
    <TD STYLE="vertical-align: bottom; font-size: 12pt">&nbsp;</TD>
    <TD STYLE="vertical-align: top">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; text-align: center">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; text-align: center">&nbsp;</TD></TR>
<tr>
    <td style="vertical-align: bottom; border-bottom: Black 1pt solid">/s/ Christian Merle</td>
    <td style="vertical-align: top">&nbsp;</td>
    <td style="vertical-align: bottom; text-align: center">Director</td>
    <td style="vertical-align: bottom; text-align: center">September 21, 2016</td></tr>
<tr>
    <td style="vertical-align: bottom; font-size: 12pt"><font style="font-size: 10pt">Christian Merle</font></td>
    <td style="vertical-align: top">&nbsp;</td>
    <td style="vertical-align: bottom; text-align: center">&nbsp;</td>
    <td style="vertical-align: bottom; text-align: center">&nbsp;</td></tr>
<TR>
    <TD STYLE="vertical-align: bottom; font-size: 12pt">&nbsp;</TD>
    <TD STYLE="vertical-align: top">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; text-align: center">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; text-align: center">&nbsp;</TD></TR>
<tr>
    <td style="vertical-align: bottom; border-bottom: Black 1pt solid">/s/ Francois Nader</td>
    <td style="vertical-align: top">&nbsp;</td>
    <td style="vertical-align: bottom; text-align: center">Director</td>
    <td style="vertical-align: bottom; text-align: center">September 19, 2016</td></tr>
<tr>
    <td style="vertical-align: bottom">Francois Nader</td>
    <td style="vertical-align: top">&nbsp;</td>
    <td style="vertical-align: bottom; text-align: center">&nbsp;</td>
    <td style="vertical-align: bottom; text-align: center">&nbsp;</td></tr>
<TR>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: top">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; text-align: center">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; text-align: center">&nbsp;</TD></TR>
<tr>
    <td style="vertical-align: bottom; border-bottom: Black 1pt solid">/s/ Leopoldo Zambeletti</td>
    <td style="vertical-align: top">&nbsp;</td>
    <td style="vertical-align: bottom; text-align: center">Director</td>
    <td style="vertical-align: bottom; text-align: center">September 21, 2016</td></tr>
<tr>
    <td style="vertical-align: bottom">Leopoldo Zambeletti</td>
    <td style="vertical-align: top">&nbsp;</td>
    <td style="vertical-align: bottom; text-align: center">&nbsp;</td>
    <td style="vertical-align: bottom; text-align: center">&nbsp;</td></tr>
</table>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>EXHIBIT INDEX</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="5" STYLE="width: 100%; font: 10pt Times New Roman, Times, Serif; border-collapse: collapse">
<tr style="vertical-align: top">
    <TD STYLE="width: 9%">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; border-bottom: Black 0.5pt solid">Exhibit Number&nbsp;</P></td>
    <TD STYLE="width: 91%; font-size: 12pt">&nbsp;</td></tr>
</table>
<TABLE CELLSPACING="0" CELLPADDING="5" STYLE="width: 100%; font: 10pt Times New Roman, Times, Serif; border-collapse: collapse">
<tr>
    <TD STYLE="vertical-align: top; width: 9%; font-size: 12pt"><font style="font-size: 10pt">4.1</font></td>
    <TD STYLE="vertical-align: bottom; width: 91%"><font style="font-size: 10pt">English Translation of Advanced Acceleration Application Articles of Association (incorporated herein by reference to the annual report on Form 20-F, filed on April 29, 2016)</font></td></tr>
<tr style="vertical-align: top">
    <TD STYLE="font-size: 12pt"><font style="font-size: 10pt">4.2</font></td>
    <TD STYLE="font-size: 12pt"><font style="font-size: 10pt">Form of Deposit Agreement among Advanced Accelerator Applications S.A., The Bank of New York Mellon, as depositary, and owners and holders of American Depositary Shares (incorporated by reference to our Registration Statement on Form F-6 (File No. 333-201502) filed with the SEC on January 14, 2015)</font><br>
<br>
</td></tr>
<tr style="vertical-align: top">
    <TD STYLE="font-size: 12pt"><font style="font-size: 10pt">4.3</font></td>
    <TD STYLE="font-size: 12pt"><font style="font-size: 10pt">Form of American Depositary Receipt (included in Exhibit 4.2)</font></td></tr>
<tr style="vertical-align: top">
    <TD STYLE="font-size: 12pt"><font style="font-size: 10pt">5</font></td>
    <TD STYLE="font-size: 12pt"><font style="font-size: 10pt">Opinion of Edward Sturchio, counsel of Advanced Accelerator Applications S.A. (filed herewith)</font></td></tr>
<tr style="vertical-align: top">
    <TD STYLE="font-size: 12pt"><font style="font-size: 10pt">23.1</font></td>
    <TD STYLE="font-size: 12pt"><font style="font-size: 10pt">Consent of Edward Sturchio, counsel of Advanced Accelerator Applications S.A. (included in Exhibit 5)</font><br>
<br>
</td></tr>
<tr style="vertical-align: top">
    <TD STYLE="font-size: 12pt"><font style="font-size: 10pt">23.2</font></td>
    <TD STYLE="font-size: 12pt"><font style="font-size: 10pt">Consent of KPMG Audit, independent registered public accounting firm (filed herewith)</font></td></tr>
<tr style="vertical-align: top">
    <TD STYLE="font-size: 12pt"><font style="font-size: 10pt">24</font></td>
    <TD STYLE="font-size: 12pt"><font style="font-size: 10pt">Powers of Attorney (included in the signature pages hereto)</font></td></tr>
<tr>
    <TD STYLE="vertical-align: top; font-size: 12pt"><font style="font-size: 10pt">99.1</font></td>
    <TD STYLE="vertical-align: bottom"><font style="font-size: 10pt">Advanced Accelerator Applications S.A. 2016 Warrant Plan</font></td></tr>
<tr>
    <TD STYLE="vertical-align: top; font-size: 12pt"><font style="font-size: 10pt">99.2</font></td>
    <TD STYLE="vertical-align: bottom; font-size: 12pt"><font style="font-size: 10pt">Advanced Accelerator Applications S.A. 2015 Stock Option Plan (incorporated herein by reference to Exhibit 10.11 to the Company&rsquo;s Registration Statement on Form F-1 (File No. 333-207223) filed with the SEC on October 1, 2015)</font></td></tr>
<tr>
    <TD STYLE="vertical-align: top; font-size: 12pt"><font style="font-size: 10pt">99.3</font></td>
    <TD STYLE="vertical-align: bottom"><font style="font-size: 10pt">Advanced Accelerator Applications S.A. 2013 Free Share Plan</font></td></tr>
<tr>
    <TD STYLE="vertical-align: top; font-size: 12pt"><font style="font-size: 10pt">99.4</font></td>
    <TD STYLE="vertical-align: bottom"><font style="font-size: 10pt">Advanced Accelerator Applications S.A. 2010 Free Share Plan</font></td></tr>
</table>


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[{"type": "S-8", "sequence": "1", "filename": "dp68694_s8.htm", "description": "FORM S-8", "secsgml_size_bytes": 60995}]
{"company-data": {"conformed-name": "Advanced Accelerator Applications S.A.", "cik": "0001611787", "assigned-sic": "2834", "irs-number": "000000000", "state-of-incorporation": "I0", "fiscal-year-end": "1231"}, "filing-values": {"form-type": "S-8", "act": "33", "file-number": "333-213733", "film-number": "161896098"}, "business-address": {"street1": "20 RUE DIESEL", "city": "01630 SAINT GENIS POUILLY", "state": "I0", "zip": "00000", "phone": "33 4 50 99 30 70"}, "mail-address": {"street1": "20 RUE DIESEL", "city": "01630 SAINT GENIS POUILLY", "state": "I0", "zip": "00000"}}
As filed with the Securities and Exchange
Commission on September 21, 2016
Registration
No. 333-
UNITED STATES
SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM S-8
REGISTRATION STATEMENT
UNDER THE SECURITIES ACT OF 1933
ADVANCED ACCELERATOR APPLICATIONS S.A.
(Exact Name of Registrant as specified
in its charter)
France
N/A
(State or other jurisdiction of
incorporation or organization)
(I.R.S. Employer
Identification No.)
20 rue Diesel
01630 Saint Genis Pouilly, France
(Address including zip code of Principal Executive Offices)
Advanced Accelerator Applications S.A
        2016 Warrant Plan
Advanced Accelerator Applications S.A 2015 Stock Option Plan
Advanced Accelerator Applications S.A.
        2013 Free Share Plan
Advanced Accelerator Applications S.A 2010 Free Share Plan
(Full title of the plans)
Edward Sturchio
Global General Counsel
Advanced Accelerator Applications S.A.
The Empire State Building
350 Fifth Avenue, Suite 6902
New York, NY, 10118, USA
National Registered Agents, Inc.
111 Eighth Avenue,
New York,
New York 10011
(888-579-0286)
(Name, address and telephone number, including
        area code, of agent for service)
Copies to
:
John Crowley
Davis Polk & Wardwell LLP
450 Lexington Avenue
New York, NY 10017
Indicate by check mark whether the registrant
is a large accelerated filer, an accelerated filer, a non-accelerated filer, or a smaller reporting company. See the definitions
of "large accelerated filer," "accelerated filer" and "smaller reporting company" in Rule 12b-2
of the Exchange Act.
Large accelerated filer
☐
Accelerated filer
☐
Non-accelerated filer
☒
(Do not check if a smaller
reporting company)
Smaller reporting company
☐
CALCULATION OF REGISTRATION FEE
Title of Securities to be Registered
Amount to be
Registered
(1)
Proposed Maximum Offering Price Per Share
(2)
Proposed Maximum  Aggregate
Offering Price
Amount of
Registration Fee
(3)
Ordinary Shares, par value €0.10 each, reserved for issuance pursuant to the Advanced Accelerator Applications S.A. 2016 Warrant Plan
(4)
149,800
$17.11
$2,563,078.00
258.10
Ordinary Shares, par value €0.10 each, reserved for issuance pursuant to the Advanced Accelerator Applications S.A. 2015 Stock Option Plan
(4)
12,204,561
$17.11
$208,820,038.71
21,028.18
Ordinary Shares, par value €0.10  each, reserved for issuance pursuant to the Advanced Accelerator Applications S.A. 2013 Free Share Plan
(4)
500,000
$17.11
8,555,000.00
861.49
Ordinary Shares, par value €0.10 each, reserved for issuance pursuant to the Advanced Accelerator Applications S.A. 2010 Free Share Plan
(4)
547,500
$17.11
9,367,725.00
943.33
Total Ordinary Shares
13,401,861
$17.11
229,305,841.71
23,091.10
(1)
This Registration Statement on Form S-8 (this "Registration Statement") covers ordinary shares of €0.10 each
par value ("Ordinary Shares"), of Advanced Accelerator Applications S.A. (the "Registrant") issuable pursuant
to the plans set forth in this table (collectively, the "Plans"). Pursuant to Rule 416(a) under the Securities Act
of 1933, as amended (the "Securities Act"), this Registration Statement shall also cover any additional Ordinary Shares
that become issuable under the Plans by reason of any share dividend, share split or other similar transaction.
(2)
Computed solely for the purpose of calculating the registration
fee pursuant to Rule 457(c) and 457(h) under the Securities Act on the basis of the average high and low sale price on the NASDAQ
Global Select Market on September 14, 2016.
(3)
Rounded up to the nearest penny.
(4)
The Ordinary Shares being registered hereby may be represented by the Registrant's American Depositary Shares, evidenced
by American Depositary Receipts. One of the Registrant's American Depositary Shares corresponds to two Ordinary Shares.
PART I
INFORMATION REQUIRED
IN THE SECTION 10(a) PROSPECTUS
The documents containing the information
specified in Item 1 and Item 2 of Part I of Form S-8 will be sent or given to participants as specified by Rule 428(b)(1) under
the Securities Act. In accordance with the rules and regulations of the U.S. Securities and Exchange Commission (the "Commission")
and the instructions to Form S-8, such documents are not being filed with the Commission either as part of this Registration Statement
or as prospectuses or prospectus supplements pursuant to Rule 424 under the Securities Act.
PART II
INFORMATION REQUIRED
IN THE REGISTRATION STATEMENT
Item 3. Incorporation of Documents by Reference.
The following documents are incorporated herein
by reference:
(a) The Registrant's Annual Report on
Form 20-F for the fiscal year ended December 31, 2015 and filed on April 29, 2016.
(b) All other reports filed by the Registrant
pursuant to Sections 13(a) or 15(d) of the Exchange Act since the end of the fiscal year covered by the Annual Report on Form 20-F
referred to in Item 3(a) above.
(c) The description of the Registrant's
American Depositary Shares evidenced by American Depositary Receipts, each representing two Ordinary Shares, and Ordinary Shares
contained in the Registrant's Registration Statement on Form F-1/A dated November 2, 2015, filed under the Exchange Act,
including any amendment thereto or report filed for the purpose of updating such description.
In addition, all documents subsequently filed
by the Registrant with the Commission pursuant to Sections 13(a), 13(c), 14 and 15(d) of the Exchange Act, prior to the filing
of a post-effective amendment to this Registration Statement which indicates that all securities offered have been sold or which
deregisters all securities then remaining unsold, including any Reports of Foreign Private Issuers on Form 6-K submitted during
such period (or portion thereof) that is identified in such form as being incorporated by reference into this Registration Statement,
shall be deemed to be incorporated by reference in this Registration Statement and to be a part hereof from the date of the filing
of such documents. The Registrant is not incorporating by reference any documents or portions thereof, whether specifically listed
above or filed in the future, that are not deemed "filed" with the Commission.
Any statement contained in a document incorporated
or deemed to be incorporated by reference herein shall be deemed to be modified or superseded for purposes of this Registration
Statement to the extent that a statement contained herein, (or in any other subsequently filed document which also is incorporated
or deemed to be incorporated by reference herein), modifies or supersedes such statement. Any such statement so modified or superseded
shall not be deemed, except as so modified or superseded, to constitute a part of this Registration Statement.
Item 4. Description of Securities.
Not applicable, see Item 3(c).
Item 5. Interests of Named Experts and Counsel.
Mr. Edward Sturchio, who is
giving an opinion on the validity of the securities being registered, is Global General Counsel for the Company and may hold equity
interest in the Company from time to time.
Item 6. Indemnification of Directors and Officers.
Under French law, provisions of by-laws that limit the liability
of directors are prohibited. However, French law allows
sociétés anonymes
to contract for and maintain liability
insurance against civil liabilities incurred by any of their directors and officers involved in a third-party action, provided
that they acted in good faith and within their
capacities as directors or officers of the company. Criminal
liability cannot be indemnified under French law, whether directly by the company or through liability insurance.
We maintain liability insurance for our directors and officers,
including insurance against liability under the Securities Act of 1933, as amended, and we may enter into agreements with our directors
and executive officers to provide contractual indemnification.
With certain exceptions and subject to limitations on indemnification
under French law, these agreements provide for indemnification for damages and expenses including, among other things, attorneys'
fees, judgments, fines and settlement amounts incurred by any of these individuals in any action or proceeding arising out of his
or her actions in that capacity. We believe that this insurance and these agreements are necessary to attract and maintain qualified
directors and executive officers.
These agreements may discourage shareholders from bringing a
lawsuit against our directors and executive officers for breach of their fiduciary duty. These provisions also may have the effect
of reducing the likelihood of derivative litigation against directors and executive officers, even though such an action, if successful,
might otherwise benefit us and our shareholders. Furthermore, a shareholder's investment may be adversely affected to the
extent we pay the costs of settlement and damage awards against directors and officers pursuant to these insurance agreements.
Certain of our non-employee directors may, through their relationships
with their employers or partnerships, be insured against certain liabilities in their capacity as members of our board of direc
tors.
Item 7. Exemption from Registration Claimed.
Not applicable.
Item 8. Exhibits.
Exhibit Number
4.1
English Translation of Advanced Acceleration Applications S.A. Articles of Association (incorporated herein by reference to the annual report on Form 20-F, filed on April 29, 2016)
4.2
Form of Deposit Agreement among Advanced Accelerator Applications S.A., The Bank of New York Mellon, as depositary, and owners and holders of American Depositary Shares (incorporated by reference to our Registration Statement on Form F-6 (File No. 333-201502) filed with the SEC on January 14, 2015)
4.3
Form of American Depositary Receipt (included in Exhibit 4.2)
5
Opinion of Edward Sturchio, counsel of Advanced Accelerator Applications S.A. (filed herewith)
23.1
Consent of Edward Sturchio, counsel of Advanced Accelerator Applications S.A. (included in Exhibit 5)
23.2
Consent of KPMG Audit, independent registered public accounting firm (filed herewith)
24
Powers of Attorney (included in the signature pages hereto)
99.1
Advanced Accelerator Applications S.A. 2016 Warrant Plan
99.2
Advanced Accelerator Applications S.A. 2015 Stock Option Plan (incorporated herein by reference to Exhibit 10.11 to the Company's Registration Statement on Form F-1 (File No. 333-207223) filed with the SEC on October 1, 2015)
99.3
Advanced Accelerator Applications S.A. 2013 Free Share Plan
99.4
Advanced Accelerator Applications S.A. 2010 Free Share Plan
Item 9. Undertakings.
(a)	   The undersigned Registrant hereby
undertakes:
(1)	   To file, during any period
in which offers or sales are being made, a post-effective amendment to this Registration Statement:
(i)	   To include any prospectus
required by Section 10(a)(3) of the Securities Act;
(ii)	   To reflect in the prospectus
any facts or events arising after the effective date of this Registration Statement (or the most recent post-effective amendment
thereof) which, individually or in the aggregate, represent a fundamental change in the information set forth in this Registration
Statement. Notwithstanding the foregoing, any increase or decrease in volume of securities offered (if the total dollar value of
securities offered would not exceed that which was registered) and any deviation from the low or high end of the estimated maximum
offering range may be reflected in the form of prospectus filed with the Commission pursuant to Rule 424(b) if, in the
aggregate, the changes in volume and price represent no more than a 20 percent change in the maximum aggregate offering price set
forth in the "Calculation of Registration Fee" table in the effective Registration Statement;
(iii)	   To include any material
information with respect to the Plans not previously disclosed in this Registration Statement or any material change to such information
in this Registration Statement;
provided
,
however
,
that paragraphs (a)(1)(i) and (a)(1)(ii) do not apply if the information required to be included in a post-effective amendment
by those paragraphs is contained in periodic reports filed with or furnished to the Commission by the Registrant pursuant to Section
13 or 15(d) of the Exchange Act that are incorporated by reference in this Registration Statement.
(2)	   That, for the purpose
of determining any liability under the Securities Act, each such post-effective amendment shall be deemed to be a new registration
statement relating to the securities offered therein, and the offering of such securities at that time shall be deemed to be the
initial
bona fide
offering thereof.
(3)	   To remove from registration
by means of a post-effective amendment any of the securities being registered which remain unsold at the termination of the offering.
(b)	   The undersigned Registrant hereby
undertakes that, for purposes of determining any liability under the Securities Act, each filing of the Registrant's annual
report pursuant to Section 13(a) or 15(d) of the Exchange Act (and, where applicable, each filing of an employee benefit plan's
annual report pursuant to Section 15(d) of the Exchange Act) that is incorporated by reference in this Registration Statement shall
be deemed to be a new registration statement relating to the securities offered therein, and the offering of such securities at
that time shall be deemed to be the initial
bona fide
offering thereof.
(c)	   Insofar as indemnification for liabilities
arising under the Securities Act may be permitted to directors, officers and controlling persons of the Registrant pursuant to
the foregoing provisions, or otherwise, the Registrant has been advised that in the opinion of the Commission such indemnification
is against public policy as expressed in the Securities Act and is, therefore, unenforceable. In the event that a claim for indemnification
against such liabilities (other than the payment by the Registrant of expenses incurred or paid by a director, officer or controlling
person of the Registrant in the successful defense of any action, suit or proceeding) is asserted by such director, officer or
controlling person in connection with the securities being registered, the Registrant will, unless in the opinion of its counsel
the matter has been settled by controlling precedent, submit to a court of appropriate jurisdiction the question whether such indemnification
by it is against public policy as expressed in the Securities Act and will be governed by the final adjudication of such issue.
SIGNATURES
Pursuant to the requirements of the Securities
Act, the Registrant certifies that it has reasonable grounds to believe that it meets all of the requirements for filing this
Registration Statement and has duly caused this Registration Statement to be signed on its behalf by the undersigned, thereunto
duly authorized, in the City of Saint Genis Pouilly, France, on this 21
st
day of September, 2016.
Advanced Accelerator Applications S.A.
By:
/s/Heinz Mäusli
Name:
Heinz Mäusli
Title:
Chief Financial Officer
Advanced Accelerator Applications USA, Inc.
(Authorized Representative in the United States)
By:
/s/ Edward A. Sturchio
Name:
Edward A. Sturchio
Title:
Global General Counsel
POWER OF ATTORNEY
KNOW ALL PERSONS
BY THESE PRESENTS, that each person whose signature appears below constitutes and appoints Stefano Buono, Heinz Mäusli, Jordan
Silverstein and Edward Sturchio, as his or her true and lawful attorneys-in-fact and agent, with full power of substitution and
resubstitution, for him or her and in his or her name, place and stead, in any and all capacities, to sign any and all amendments
(including post-effective amendments) to this Registration Statement and any and all additional registration statements pursuant
to Rule 462(b) of the Securities Act of 1933, as amended, and to file the same, with all exhibits thereto, and all other documents
in connection therewith, with the U.S. Securities and Exchange Commission, granting unto said attorneys-in-fact and agent full
power and authority to do and perform each and every act in person, hereby ratifying and confirming all that said attorney-in-fact
and agent or his substitutes may lawfully do or cause to be done by virtue hereof.
Pursuant to the
requirements of the Securities Act of 1933, as amended, this Registration Statement has been signed by the following persons in
the capacities and on the dates indicated.
Signature
Title
Date
/s/ Stefano Buono
Chief Executive Officer, Director
September 21, 2016
Stefano Buono
(Principal Executive Officer)
/s/ Heinz Mäusli
Chief Financial Officer
September 21, 2016
Heinz Mäusli
(Principal Financial and Accounting Officer)
/s/ Claudio Costamagna
Director
September 21, 2016
Claudio Costamagna
/s/ Kapil Dhingra
Director
September 19, 2016
Kapil Dhingra
/s/
Steve
    Gannon
Director
September 21, 2016
Steve Gannon
/s/
Yvonne Greenstreet
Director
September 21, 2016
Yvonne Greenstreet
/s/ Christian Merle
Director
September 21, 2016
Christian Merle
/s/ Francois Nader
Director
September 19, 2016
Francois Nader
/s/ Leopoldo Zambeletti
Director
September 21, 2016
Leopoldo Zambeletti
EXHIBIT INDEX
Exhibit Number
4.1
English Translation of Advanced Acceleration Application Articles of Association (incorporated herein by reference to the annual report on Form 20-F, filed on April 29, 2016)
4.2
Form of Deposit Agreement among Advanced Accelerator Applications S.A., The Bank of New York Mellon, as depositary, and owners and holders of American Depositary Shares (incorporated by reference to our Registration Statement on Form F-6 (File No. 333-201502) filed with the SEC on January 14, 2015)
4.3
Form of American Depositary Receipt (included in Exhibit 4.2)
5
Opinion of Edward Sturchio, counsel of Advanced Accelerator Applications S.A. (filed herewith)
23.1
Consent of Edward Sturchio, counsel of Advanced Accelerator Applications S.A. (included in Exhibit 5)
23.2
Consent of KPMG Audit, independent registered public accounting firm (filed herewith)
24
Powers of Attorney (included in the signature pages hereto)
99.1
Advanced Accelerator Applications S.A. 2016 Warrant Plan
99.2
Advanced Accelerator Applications S.A. 2015 Stock Option Plan (incorporated herein by reference to Exhibit 10.11 to the Company's Registration Statement on Form F-1 (File No. 333-207223) filed with the SEC on October 1, 2015)
99.3
Advanced Accelerator Applications S.A. 2013 Free Share Plan
99.4
Advanced Accelerator Applications S.A. 2010 Free Share Plan