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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>As filed with the Securities and Exchange
Commission on August 4, 2017</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 108pt; text-align: right"><B>Registration No. 333-&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; </B></P>

<P STYLE="font: 5pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 108pt; text-align: right">&nbsp;</P>
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<P STYLE="font: 16pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>UNITED STATES</B></P>

<P STYLE="font: 16pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>SECURITIES AND EXCHANGE COMMISSION</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>Washington, D.C. 20549</B></P>

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<P STYLE="font: 16pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>FORM S-8</B></P>

<P STYLE="font: 16pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>REGISTRATION STATEMENT</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B><I>UNDER</I></B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B><I>THE SECURITIES ACT OF 1933</I></B></P>

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<P STYLE="font: 21pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>CLEMENTIA PHARMACEUTICALS INC.</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>(Exact Name of Registrant as Specified
in its Charter)</B></P>

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<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: center; width: 34%"><FONT STYLE="font-size: 10pt"><B>Canada</B></FONT></TD>
    <TD STYLE="text-align: center; width: 32%"><FONT STYLE="font-size: 10pt"><B>2834</B></FONT></TD>
    <TD STYLE="text-align: center; width: 34%"><FONT STYLE="font-size: 10pt"><B>98-1128564</B></FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: center"><FONT STYLE="font-size: 10pt"><B>(State or other jurisdiction of</B></FONT><BR>
<FONT STYLE="font-size: 10pt"><B>incorporation or organization)</B></FONT></TD>
    <TD STYLE="text-align: center"><FONT STYLE="font-size: 10pt"><B>(Primary Standard Industrial</B></FONT><BR>
<FONT STYLE="font-size: 10pt"><B>Classification Code Number)</B></FONT></TD>
    <TD STYLE="text-align: center"><FONT STYLE="font-size: 10pt"><B>(I.R.S. Employer</B></FONT><BR>
<FONT STYLE="font-size: 10pt"><B>Identification No.)</B></FONT></TD></TR>
</TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>&nbsp;</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>4150 St Catherine Street West, Suite
550<BR>
Montreal, Quebec, Canada H3Z 2Y5<BR>
(514) 940-3600</B></P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>(Address, including zip code, and telephone
number, including area code, of Registrant&#8217;s principal executive offices)</B></P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>CLEMENTIA PHARMACEUTICALS INC. THIRD
AMENDED AND RESTATED STOCK OPTION PLAN<BR>
CLEMENTIA PHARMACEUTICALS INC. 2017 OMNIBUS INCENTIVE PLAN<BR>
CLEMENTIA PHARMACEUTICALS INC. EMPLOYEE STOCK PURCHASE PLAN<BR>
(Full title of the plan)</B></P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>The Corporation Trust Company<BR>
Corporation Trust Center<BR>
1209 Orange Street<BR>
Wilmington, DE 19801<BR>
Telephone: (302) 658-7581</B></P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>(Name, address, including zip code, and
telephone number, including area code, of agent for service)</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>
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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B><I>Copies to:</I></B></P>

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<TABLE CELLSPACING="0" CELLPADDING="0" ALIGN="CENTER" STYLE="font: 10pt Times New Roman, Times, Serif; width:100%; border-collapse: collapse">
<TR>
    <TD STYLE="vertical-align: top; width: 100%; text-align: center"><FONT STYLE="font-size: 10pt"><B>Kevin T. Collins</B></FONT><BR>
<FONT STYLE="font-size: 10pt"><B>Martin C. Glass</B></FONT><BR>
<FONT STYLE="font-size: 10pt"><B>Jenner &amp; Block LLP</B></FONT><BR>
<FONT STYLE="font-size: 10pt"><B>919 Third Avenue</B></FONT><BR>
<FONT STYLE="font-size: 10pt"><B>New York, NY 10022</B></FONT><BR>
<FONT STYLE="font-size: 10pt"><B>(212) 891-1600</B></FONT></TD>
    </TR>
</TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 18pt">&nbsp;</P>
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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 18pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 18pt">Indicate by check mark whether the registrant
is a large accelerated filer, an accelerated filer, a non-accelerated filer, or a smaller reporting company. See the definitions
of &#8220;large accelerated filer,&#8221; &#8220;accelerated filer&#8221; and &#8220;smaller reporting company&#8221; in Rule 12b-2
of the Exchange Act.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 18pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Indicate by check mark whether the registrant is an emerging
growth company as defined in Rule 405 of the Securities Act of 1933.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: right">Emerging growth company <FONT STYLE="font-family: Wingdings">x</FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: right">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="width: 100%; font: 10pt Times New Roman, Times, Serif; border-collapse: collapse">
<TR STYLE="vertical-align: bottom">
    <TD NOWRAP STYLE="width: 18%"><FONT STYLE="font-size: 10pt">Large accelerated filer&nbsp;&nbsp;</FONT></TD>
    <TD STYLE="width: 65%"><FONT STYLE="font: 10pt Wingdings">o</FONT></TD>
    <TD STYLE="width: 15%"><FONT STYLE="font-size: 10pt">Accelerated filer</FONT></TD>
    <TD STYLE="width: 2%; text-align: left"><FONT STYLE="font: 10pt Wingdings">o</FONT></TD></TR>
<TR STYLE="vertical-align: bottom">
    <TD><FONT STYLE="font-size: 10pt">Non-accelerated filer</FONT></TD>
    <TD><FONT STYLE="font: 10pt Wingdings">x</FONT><FONT STYLE="font-size: 10pt">&nbsp;&nbsp;(Do not check if a smaller reporting company)</FONT></TD>
    <TD NOWRAP><FONT STYLE="font-size: 10pt">Smaller reporting company&nbsp;&nbsp;</FONT></TD>
    <TD STYLE="text-align: left"><FONT STYLE="font: 10pt Wingdings">o</FONT></TD></TR>
</TABLE>


<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>&nbsp;</B></P>
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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>&nbsp;</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>CALCULATION OF REGISTRATION FEE</B></P>

<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="border-collapse: collapse; width: 100%; font: 10pt Times New Roman, Times, Serif">
<TR STYLE="vertical-align: bottom">
    <TD STYLE="font-weight: bold; text-align: center; border-bottom: Black 1px solid; border-top: Black 3px double">Title Of Each Class Of<BR> Securities To Be Registered</TD><TD STYLE="font-weight: bold; border-bottom: Black 1px solid; border-top: Black 3px double; border-right: Black 1px solid">&nbsp;</TD>
    <TD STYLE="font-weight: bold; text-align: center; border-bottom: Black 1px solid; border-top: Black 3px double"><FONT STYLE="font-size: 10pt"><B>Amount </B></FONT><BR> <FONT STYLE="font-size: 10pt"><B>to be</B></FONT><BR> <FONT STYLE="font-size: 10pt"><B>Registered<SUP>(1) (2)</SUP></B></FONT></TD><TD STYLE="font-weight: bold; border-bottom: Black 1px solid; border-top: Black 3px double">&nbsp;</TD>
    <TD STYLE="font-weight: bold; text-align: center; border-bottom: Black 1px solid; border-top: Black 3px double">Proposed<BR> Maximum<BR> Offering Price<BR> Per Share</TD><TD STYLE="font-weight: bold; border-bottom: Black 1px solid; border-top: Black 3px double; border-right: Black 1px solid">&nbsp;</TD>
    <TD STYLE="font-weight: bold; text-align: center; border-bottom: Black 1px solid; border-top: Black 3px double">Proposed<BR> Maximum<BR> Aggregate<BR> Offering Price</TD><TD STYLE="font-weight: bold; border-bottom: Black 1px solid; border-top: Black 3px double; border-right: Black 1px solid">&nbsp;</TD>
    <TD STYLE="font-weight: bold; text-align: center; border-bottom: Black 1px solid; border-top: Black 3px double">Amount of<BR> Registration Fee</TD></TR>
<TR STYLE="vertical-align: bottom">
    <TD STYLE="width: 35%; text-align: left; border-bottom: Black 1px solid; text-indent: -10pt; padding-left: 10pt">Common Shares, no par value, to be issued under the Clementia Pharmaceuticals Inc. Third Amended and Restated Stock Option Plan (the &ldquo;Stock Option Plan&rdquo;)</TD><TD STYLE="width: 2%; border-bottom: Black 1px solid; border-right: Black 1px solid">&nbsp;</TD>
    <TD STYLE="width: 15%; text-align: center; border-bottom: Black 1px solid; vertical-align: top"><FONT STYLE="font-size: 10pt">3,786,885 <SUP>(3)</SUP></FONT></TD><TD STYLE="width: 1%; border-bottom: Black 1px solid; text-align: center; vertical-align: top; border-right: Black 1px solid">&nbsp;</TD>
    <TD STYLE="width: 15%; text-align: center; border-bottom: Black 1px solid; vertical-align: top"><FONT STYLE="font-size: 10pt">$16.13<SUP> (4)</SUP></FONT></TD><TD STYLE="width: 1%; border-bottom: Black 1px solid; text-align: center; vertical-align: top; border-right: Black 1px solid">&nbsp;</TD>
    <TD STYLE="width: 15%; text-align: center; border-bottom: Black 1px solid; vertical-align: top"><FONT STYLE="font-size: 10pt">$61,082,455 <SUP>(4)</SUP></FONT></TD><TD STYLE="width: 1%; border-bottom: Black 1px solid; text-align: center; vertical-align: top; border-right: Black 1px solid">&nbsp;</TD>
    <TD STYLE="width: 15%; text-align: center; border-bottom: Black 1px solid; vertical-align: top">$7,079.46</TD></TR>
<TR STYLE="vertical-align: bottom">
    <TD STYLE="text-align: left; border-bottom: Black 1px solid; text-indent: -10pt; padding-left: 10pt">Common Shares, no par value, to be issued under the Clementia Pharmaceuticals Inc. 2017 Omnibus Incentive Plan (the &ldquo;Omnibus Plan&rdquo;)</TD><TD STYLE="border-bottom: Black 1px solid; border-right: Black 1px solid">&nbsp;</TD>
    <TD STYLE="text-align: center; border-bottom: Black 1px solid; vertical-align: top">2,339,176</TD><TD STYLE="border-bottom: Black 1px solid; text-align: center; vertical-align: top; border-right: Black 1px solid">&nbsp;</TD>
    <TD STYLE="text-align: center; border-bottom: Black 1px solid; vertical-align: top"><FONT STYLE="font-size: 10pt">$16.13 <SUP>(4)</SUP></FONT></TD><TD STYLE="border-bottom: Black 1px solid; text-align: center; vertical-align: top; border-right: Black 1px solid">&nbsp;</TD>
    <TD STYLE="text-align: center; border-bottom: Black 1px solid; vertical-align: top"><FONT STYLE="font-size: 10pt">$37,730,909 <SUP>(4)</SUP></FONT></TD><TD STYLE="border-bottom: Black 1px solid; text-align: center; vertical-align: top; border-right: Black 1px solid">&nbsp;</TD>
    <TD STYLE="text-align: center; border-bottom: Black 1px solid; vertical-align: top">$4,373.02</TD></TR>
<TR STYLE="vertical-align: bottom">
    <TD STYLE="text-align: left; border-bottom: Black 1px solid; text-indent: -10pt; padding-left: 10pt">Common Shares, no par value, to be issued under, to be issued under the Clementia Pharmaceuticals Inc. Employee Stock Purchase Plan (the &ldquo;ESPP&rdquo;)</TD><TD STYLE="border-bottom: Black 1px solid; border-right: Black 1px solid">&nbsp;</TD>
    <TD STYLE="text-align: center; border-bottom: Black 1px solid; vertical-align: top">290,000</TD><TD STYLE="border-bottom: Black 1px solid; text-align: center; vertical-align: top; border-right: Black 1px solid">&nbsp;</TD>
    <TD STYLE="text-align: center; border-bottom: Black 1px solid; vertical-align: top"><FONT STYLE="font-size: 10pt">$16.13 <SUP>(4)</SUP></FONT></TD><TD STYLE="border-bottom: Black 1px solid; text-align: center; vertical-align: top; border-right: Black 1px solid">&nbsp;</TD>
    <TD STYLE="text-align: center; border-bottom: Black 1px solid; vertical-align: top"><FONT STYLE="font-size: 10pt">$4,677,700 <SUP>(4)</SUP></FONT></TD><TD STYLE="border-bottom: Black 1px solid; text-align: center; vertical-align: top; border-right: Black 1px solid">&nbsp;</TD>
    <TD STYLE="text-align: center; border-bottom: Black 1px solid; vertical-align: top">$542.15</TD></TR>
<TR STYLE="vertical-align: bottom">
    <TD STYLE="border-bottom: Black 3px double; text-indent: -10pt; padding-left: 10pt">Total</TD><TD STYLE="border-bottom: Black 3px double; border-right: Black 1px solid">&nbsp;</TD>
    <TD STYLE="text-align: center; border-bottom: Black 3px double">6,416,061</TD><TD STYLE="border-bottom: Black 3px double; border-right: Black 1px solid">&nbsp;</TD>
    <TD STYLE="text-align: center; border-bottom: Black 3px double">&nbsp;</TD><TD STYLE="border-bottom: Black 3px double; border-right: Black 1px solid">&nbsp;</TD>
    <TD STYLE="text-align: center; border-bottom: Black 3px double">&nbsp;</TD><TD STYLE="border-bottom: Black 3px double; border-right: Black 1px solid">&nbsp;</TD>
    <TD STYLE="text-align: center; border-bottom: Black 3px double">$11,994.63</TD></TR>
</TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 18pt; text-indent: -18pt">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" BORDER="0" STYLE="width: 100%; margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">
<TR STYLE="vertical-align: top">
    <TD STYLE="width: 18pt">(1)</TD>
    <TD>Represents common shares of Clementia Pharmaceuticals Inc., no par value (&#8220;Common Shares&#8221;) issuable under the Stock
Option Plan, Omnibus Plan and ESPP.</TD></TR>
</TABLE>

<TABLE CELLPADDING="0" CELLSPACING="0" BORDER="0" STYLE="width: 100%; margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">
<TR STYLE="vertical-align: top">
    <TD STYLE="width: 18pt">(2)</TD>
    <TD>Pursuant to Rule 416(a) under the Securities Act of 1933, as amended (the &#8220;Securities Act&#8221;), this registration statement
also covers an indeterminate number of additional shares that may be offered and issued under the Stock Option Plan, Omnibus Plan
and ESPP to prevent dilution resulting from share dividends, share splits, reverse share splits, recapitalizations, reclassifications,
mergers, split-ups, reorganizations, consolidations and other capital adjustments.</TD></TR>
</TABLE>

<TABLE CELLPADDING="0" CELLSPACING="0" BORDER="0" STYLE="width: 100%; margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">
<TR STYLE="vertical-align: top">
    <TD STYLE="width: 18pt">(3)</TD>
    <TD>To be issued under option awards granted under the Stock Option Plan.</TD></TR>
</TABLE>

<TABLE CELLPADDING="0" CELLSPACING="0" BORDER="0" STYLE="width: 100%; margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">
<TR STYLE="vertical-align: top">
    <TD STYLE="width: 18pt">(4)</TD>
    <TD>Estimated solely for the purpose of calculating the registration fee in accordance with paragraph (c) and (h) of Rule 457 under
the Securities Act, based on the basis of the average of the high and low prices for the Common Shares on the NASDAQ Global Select
Market on August 3, 2017.</TD></TR>
</TABLE>


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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>&nbsp;</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>PART I</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>INFORMATION REQUIRED IN THE SECTION 10(a)
PROSPECTUS</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B>Item 1. Plan Information</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">The information specified in Item 1 of Part I of Form S-8 is
omitted from this registration statement on Form S-8 in accordance with the provisions of Rule 428 under the Securities Act, and
the introductory note to Part I of Form S-8.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">The documents containing the information specified in Part
I of Form S-8 will be delivered to the participants in the Stock Option Plan, the Omnibus Plan and ESPP, as applicable,
covered by this registration statement as specified by Rule 428(b)(1) under the Securities Act. Such documents are not
required to be, and are not, filed with the Securities and Exchange Commission (the &ldquo;Commission&rdquo;) either as part of this
registration statement or as a prospectus or prospectus supplement pursuant to Rule 424 under the Securities Act.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B>Item 2. Registrant Information and Employee Plan Annual Information</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Upon written or oral request, any of the documents incorporated
by reference in Item 3 of Part II of this Registration Statement (which documents are incorporated by reference in Section 10(a)
of the prospectus) and all documents required to be delivered to employees pursuant to Rule 428(b) under the Securities Act are
available without charge by contacting:</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center">Clementia Pharmaceuticals Inc.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center">Michael Singer, Chief Financial Officer</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center">4150 St Catherine Street West, Suite 550</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center">Montreal, Quebec, Canada H3Z 2Y5</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; text-align: center; margin-bottom: 0pt">(514) 940-3610</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 252pt"></P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>PART II</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>INFORMATION REQUIRED IN THE REGISTRATION
STATEMENT</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B>Item 3. Incorporation of Documents by Reference.</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">The following documents filed with the Commission by Clementia
Pharmaceuticals Inc. (the &ldquo;Registrant,&rdquo; &ldquo;we&rdquo; or &ldquo;our&rdquo;) pursuant to the Securities Act and the
Securities Exchange Act of 1934, as amended (the &ldquo;Exchange Act&rdquo;), are hereby incorporated by reference in this registration
statement:</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 27pt"></TD><TD STYLE="width: 36pt">(a)</TD><TD>The Registrant&rsquo;s prospectus filed with the Commission on August 1, 2017 pursuant to Rule 424(b) of the Securities Act,
relating to the Form F-1 (file number 333-219066); and</TD></TR></TABLE>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 27pt"></TD><TD STYLE="width: 36pt">(b)</TD><TD>The description of the Registrant&rsquo;s common shares contained in the Registrant&rsquo;s registration statement on Form
8-A filed with the Commission on August 1, 2017, pursuant to Section 12(b) of the Securities Act, including any amendment or report
filed for the purpose of updating such description (file number 333-219066).</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">All documents that the Registrant subsequently files pursuant
to Sections 13(a), 13(c), 14 and 15(d) of the Exchange Act after the date of this registration statement and prior to the filing
of a post-effective amendment to this registration statement indicating that all securities offered have been sold or which deregisters
all securities then remaining unsold, shall be deemed to be incorporated by reference into this registration statement and to be
a part hereof from the date of filing of such documents; provided, however, that documents or information deemed to have been furnished
and not filed shall not be incorporated by reference into this registration statement.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Any statement contained in a document incorporated or deemed
to be incorporated by reference herein shall be deemed to be modified or superseded for purposes of this registration statement
to the extent that a statement contained herein or in any other subsequently filed document which also is or is deemed to be incorporated
by reference herein modifies or supersedes such statement. Any such statement so modified or superseded shall not be deemed, except
as so modified or superseded, to constitute a part of this registration statement.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B>Item 4. Description of Securities.</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Not applicable.</P>


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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B>Item 5. Interests of Named Experts and Counsel.</B></P>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Not applicable.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B>Item 6. Indemnification of Directors and Officers.</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Section 124 of the Canada Business Corporations Act (the &ldquo;CBCA&rdquo;)
authorizes corporations to indemnify past and present directors, officers and certain other individuals for the liabilities incurred
in connection with their services as such (including costs, expenses and settlement payments) if such individual acted honestly
and in good faith with a view to the best interest of the corporation and, in the case of a criminal or administrative proceeding,
if such individual had reasonable grounds for believing his or her conduct was lawful. In the case of a suit by or on behalf of
the corporation, a court must approve the indemnification.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">The Registrant&rsquo;s bylaws provide that the Registrant shall
indemnify directors and officers.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">The Registrant has entered into agreements with its directors
and officers (each an &ldquo;Indemnitee&rdquo; under such agreements) to indemnify the Indemnitee, to the extent permitted by law
and subject to certain limitations, against all costs reasonably incurred by an Indemnitee in an action or proceeding to which
the Indemnitee was made a party by reason of the Indemnitee being an officer or director of (i) the Registrant or (ii) an organization
of which the Registrant is a shareholder or creditor if the Indemnitee serves such organization at the Registrant&rsquo;s request.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">The Registrant maintains insurance policies relating to certain
liabilities that the Registrant&rsquo;s directors and officers may incur in such capacity.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">The Registrant has entered into indemnity agreements with its
directors and certain officers which provide, among other things, that the Registrant will indemnify each such individual to the
fullest extent permitted by law and as permitted by the CBCA from and against all liabilities, costs, charges and expenses that
he or she may incur as a result of his or her actions in the exercise of his or her duties as director or officer, provided that
the Registrant shall not indemnify such individual if, among other things, he or she did not act honestly and in good faith with
a view to our best interests and, in the case of a criminal or administrative action or proceeding that is enforced by a monetary
penalty, the individual had reasonable grounds for believing that his or her conduct was lawful.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B>Item 7. Exemption from Registration Claimed.</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Not applicable.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>


<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B>Item 8. Exhibits.</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 12pt Times New Roman, Times, Serif; margin: 0pt 0"><FONT STYLE="font-size: 10pt">The following exhibits are filed
or incorporated by reference as part of this registration statement:</FONT></P>

<P STYLE="font: 12pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="width: 100%; font: 10pt Times New Roman, Times, Serif; border-collapse: collapse">
<TR STYLE="vertical-align: bottom">
    <TD STYLE="border-bottom: Black 1px solid; text-align: center; width: 10%">
        <P STYLE="font: 8pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center"><B>Exhibit No.</B></P>

</TD>
    <TD STYLE="width: 3%">&nbsp;</TD>
    <TD STYLE="border-bottom: Black 1px solid; width: 87%">
        <P STYLE="font: 8pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>Description</B></P></TD>

</TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: center"><FONT STYLE="font-size: 10pt">&nbsp;&nbsp;4.1</FONT></TD>
    <TD>&nbsp;</TD>
    <TD><FONT STYLE="font-size: 10pt">Articles of Amendment of the Registrant (incorporated by reference to Exhibit 3.1 &nbsp;to
    the Registration Statement on Form F-1 (File No.333-219066) filed with the Commission on July 20, 2017)</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: center"><FONT STYLE="font-size: 10pt">&nbsp;&nbsp;4.2</FONT></TD>
    <TD>&nbsp;</TD>
    <TD><FONT STYLE="font-size: 10pt">Amended and Restated Bylaws of the Registrant (incorporated by reference to Exhibit 3.2 to the Registration Statement on Form F-1 (File No.333-219066) filed with the Commission on July 20, 2017)</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: center"><FONT STYLE="font-size: 10pt">&nbsp;&nbsp;5.1*</FONT></TD>
    <TD>&nbsp;</TD>
    <TD><FONT STYLE="font-size: 10pt">Opinion of Dentons Canada LLP</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: center"><FONT STYLE="font-size: 10pt">23.1*</FONT></TD>
    <TD>&nbsp;</TD>
    <TD><FONT STYLE="font-size: 10pt">Consent of KPMG LLP</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: center"><FONT STYLE="font-size: 10pt">23.2*</FONT></TD>
    <TD>&nbsp;</TD>
    <TD><FONT STYLE="font-size: 10pt">Consent of Dentons Canada LLP (included as part of Exhibit 5.1)</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: center"><FONT STYLE="font-size: 10pt">24.1*</FONT></TD>
    <TD>&nbsp;</TD>
    <TD STYLE="text-align: left">Power of Attorney (included on the signature pages to this registration statement)</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: center"><FONT STYLE="font-size: 10pt">&nbsp;99.1</FONT></TD>
    <TD>&nbsp;</TD>
    <TD><FONT STYLE="font-size: 10pt">Clementia Pharmaceuticals Inc. Third Amended and Restated Stock Option Plan (incorporated by reference to Exhibit 10.8 to the Registration Statement on Form F-1 (File No.333-219066) filed with the Commission on July 20, 2017)</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: center"><FONT STYLE="font-size: 10pt">&nbsp;99.2</FONT></TD>
    <TD>&nbsp;</TD>
    <TD><FONT STYLE="font-size: 10pt">Clementia Pharmaceuticals Inc. Employee Stock Purchase Plan (incorporated by reference to Exhibit 10.9 to the Registration Statement on Form F-1 (File No.333-219066) filed with the Commission on July 20, 2017)</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: center"><FONT STYLE="font-size: 10pt">&nbsp;99.3</FONT></TD>
    <TD>&nbsp;</TD>
    <TD><FONT STYLE="font-size: 10pt">Clementia Pharmaceuticals Inc. Employee Stock Purchase Plan (incorporated by reference to Exhibit 10.10 to the Registration Statement on Form F-1 (File No.333-219066) filed with the Commission on July 20, 2017)</FONT></TD></TR>
</TABLE>


<P STYLE="margin-top: 0; margin-bottom: 0; font: 10pt Arial, Helvetica, Sans-Serif">&nbsp;</P>

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<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0"></TD><TD STYLE="width: 24.45pt">*</TD><TD>Filed herewith.</TD></TR></TABLE>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B>Item 9. Undertakings.</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0"></TD><TD STYLE="width: 36pt">(a)</TD><TD>The undersigned Registrant hereby undertakes:</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 36pt"></TD><TD STYLE="width: 36pt">(1)</TD><TD>To file, during any period in which offers or sales are being made, a post-effective amendment to this registration statement:</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="width: 100%; font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 108pt"></TD><TD STYLE="width: 36pt">(i)</TD><TD>To include any prospectus required by Section 10(a)(3) of the Securities Act;</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="width: 100%; font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 108pt"></TD><TD STYLE="width: 36pt">(ii)</TD><TD>To reflect in the prospectus any facts or events arising after the effective date of the registration statement (or the most
recent post-effective amendment thereof) which, individually or in the aggregate, represent a fundamental change in the information
set forth in the registration statement. Notwithstanding the foregoing, any increase or decrease in volume of securities offered
(if the total dollar value of securities offered would not exceed that which was registered) and any deviation from the low or
high end of the estimated maximum offering range may be reflected in the form of prospectus filed with the Commission pursuant
to Rule 424(b) if, in the aggregate, the changes in volume and price represent no more than a 20 percent change in the maximum
aggregate offering price set forth in the &ldquo;Calculation of Registration Fee&rdquo; table in the effective registration statement;
and</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="width: 100%; font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 108pt"></TD><TD STYLE="width: 36pt">(iii)</TD><TD>To include any material information with respect to the plan of distribution not previously disclosed in the registration statement
or any material change to such information in the registration statement;</TD></TR></TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 72pt"><I>provided, however</I>, that paragraphs (a)(1)(i)
and (a)(1)(ii) above do not apply if the information required to be included in a post- effective amendment by those paragraphs
is contained in reports filed with or furnished to the Commission by the Registrant pursuant to Section 13 or Section 15(d) of
the Exchange Act that are incorporated by reference in this registration statement.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 72pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 72pt">(2) that, for the purpose of determining any liability
under the Securities Act, each such post- effective amendment shall be deemed to be a new registration statement relating to the
securities offered therein, and the offering of such securities at that time shall be deemed to be the initial <I>bona fide </I>offering
thereof.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 72pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 72pt">(3) to remove from registration by means of a post-
effective amendment any of the securities being registered which remain unsold at the termination of the offering.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 72pt">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0"></TD><TD STYLE="width: 36pt">(b)</TD><TD>The undersigned Registrant hereby undertakes that, for purposes of determining any liability under the Securities Act, each
filing of the Registrant&rsquo;s annual report pursuant to Section 13(a) or 15(d) of the Exchange Act (and, where applicable, each
filing of an employee benefit plan&rsquo;s annual report pursuant to Section 15(d) of the Exchange Act) that is incorporated by
reference in the registration statement shall be deemed to be a new registration statement relating to the securities offered therein,
and the offering of such securities at that time shall be deemed to be the initial <I>bona fide </I>offering thereof.</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0"></TD><TD STYLE="width: 36pt">(c)</TD><TD>Insofar as indemnification for liabilities arising under the Securities Act may be permitted to directors, officers and
                                                          controlling persons of the Registrant pursuant to the foregoing provisions, or otherwise, the Registrant has been advised
                                                          that in the opinion of the Commission such indemnification
is against public policy as expressed in the Securities Act, and is, therefore, unenforceable. In the event that a claim for indemnification
against such liabilities (other than the payment by the Registrant of expenses incurred or paid by a director, officer or controlling
person of the Registrant in the successful defense of any action, suit or proceeding) is asserted by such director, officer or
controlling person in connection with the securities being registered, the Registrant will, unless in the opinion of its counsel
the matter has been settled by controlling precedent, submit to a court of appropriate jurisdiction the question whether such indemnification
by it is against public policy as expressed in the Securities Act and will be governed by the final adjudication of such issue.</TD></TR></TABLE>

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<P STYLE="font: 12pt Times New Roman, Times, Serif; margin: 0; text-align: center"><FONT STYLE="text-transform: uppercase"><B>SIGNATURES</B></FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center"><FONT STYLE="text-transform: uppercase"><B>&nbsp;</B></FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify; text-indent: 36pt">Pursuant to the requirements
of the Securities Act, the Registrant certifies that it has reasonable grounds to believe that it meets all of the requirements
for filing on Form S-8 and has duly caused this Registration Statement to be signed on its behalf by the undersigned, thereunto
duly authorized, in the City of Montreal, Canada, on this 4th day of August, 2017.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify; text-indent: 36pt">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
<TR STYLE="vertical-align: bottom">
    <TD>&nbsp;</TD>
    <TD COLSPAN="2"><FONT STYLE="font-size: 10pt; color: black">CLEMENTIA PHARMACEUTICALS INC.</FONT></TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom">
    <TD>&nbsp;</TD>
    <TD COLSPAN="2">&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom">
    <TD STYLE="width: 50%">&nbsp;</TD>
    <TD STYLE="width: 3%"><FONT STYLE="font-size: 10pt; color: black">By</FONT></TD>
    <TD STYLE="width: 37%; border-bottom: Black 1px solid"><FONT STYLE="font-size: 10pt; color: black">/s/ Michael Singer</FONT></TD>
    <TD STYLE="width: 10%">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD><FONT STYLE="font-size: 10pt; color: black">Michael Singer</FONT></TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD><FONT STYLE="font-size: 10pt; color: black">Chief Financial Officer</FONT></TD>
    <TD>&nbsp;</TD></TR>
</TABLE>
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<P STYLE="font: 12pt Times New Roman, Times, Serif; margin: 0; text-align: center"><B>POWER OF ATTORNEY</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center"><B>&nbsp;</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify; text-indent: 36pt">KNOW ALL PERSONS BY THESE
PRESENTS, that each person whose signature appears below hereby constitutes and appoints Clarissa Desjardins and Michael Singer
as the undersigned&rsquo;s true and lawful attorneys-in-fact and agents, with full powers of substitution and resubstitution, for
such person and in such person&rsquo;s name, place and stead, in any and all capacities, to sign any and all amendments (including
pre-effective and post-effective amendments) to this registration statement and to file the same, with all exhibits thereto and
other documents in connection therewith, with the Securities and Exchange Commission, granting unto such attorneys-in-fact and
agents, full power and authority to do and perform each and every act and thing requisite or necessary to be done in and about
the premises, as fully to all intents and purposes as such person might or could do in person, hereby ratifying and confirming
all that such attorneys-in-fact and agents, or their substitute or substitutes, may lawfully do or cause to be done by virtue hereof.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center; text-indent: 0.5in"><FONT STYLE="text-transform: uppercase"><B>&nbsp;</B></FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify; text-indent: 36pt">Pursuant to the requirements
of the Securities Act, this Registration Statement has been signed below by the following persons in the capacities indicated on
this 4th day of August, 2017.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify; text-indent: 36pt">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
<TR STYLE="vertical-align: top">
    <TD STYLE="width: 30%; border-bottom: Black 1px solid"><FONT STYLE="font-size: 10pt; color: black">Signature</FONT></TD>
    <TD STYLE="width: 5%">&nbsp;</TD>
    <TD STYLE="width: 40%; border-bottom: Black 1px solid"><FONT STYLE="font-size: 10pt; color: black">Title</FONT></TD>
    <TD STYLE="width: 5%">&nbsp;</TD>
    <TD STYLE="width: 20%">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="border-bottom: Black 1px solid"><FONT STYLE="font-size: 10pt; color: black">/s/ Clarissa Desjardins</FONT></TD>
    <TD>&nbsp;</TD>
    <TD><FONT STYLE="font-size: 10pt; color: black">Chief Executive Officer and Director (Principal </FONT></TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD><FONT STYLE="font-size: 10pt; color: black">Clarissa Desjardins</FONT></TD>
    <TD>&nbsp;</TD>
    <TD><FONT STYLE="font-size: 10pt; color: black">Executive Officer)</FONT></TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="border-bottom: Black 1px solid">/s/ Michael Singer</TD>
    <TD>&nbsp;</TD>
    <TD>Chief Financial Officer (Principal Financial </TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>Michael Singer</TD>
    <TD>&nbsp;</TD>
    <TD> Officer and Principal Accounting Officer)</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD><FONT STYLE="font-size: 10pt; color: black">/s/ David P. Bonita</FONT></TD>
    <TD>&nbsp;</TD>
    <TD><FONT STYLE="font-size: 10pt; color: black">Chairman of the Board of Directors</FONT></TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="border-top: Black 1px solid"><FONT STYLE="font-size: 10pt; color: black;">David P. Bonita</FONT></TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="border-bottom: Black 1px solid"><FONT STYLE="font-size: 10pt; color: black">/s/ Robert Heft</FONT></TD>
    <TD>&nbsp;</TD>
    <TD><FONT STYLE="font-size: 10pt; color: black">Director</FONT></TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD><FONT STYLE="font-size: 10pt; color: black">Robert Heft</FONT></TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="border-bottom: Black 1px solid"><FONT STYLE="font-size: 10pt; color: black">/s/ Allan Mandelzys</FONT></TD>
    <TD>&nbsp;</TD>
    <TD><FONT STYLE="font-size: 10pt; color: black">Director</FONT></TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD><FONT STYLE="font-size: 10pt; color: black">Allan Mandelzys</FONT></TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="border-bottom: Black 1px solid"><FONT STYLE="font-size: 10pt; color: black">/s/ David Mott</FONT></TD>
    <TD>&nbsp;</TD>
    <TD><FONT STYLE="font-size: 10pt; color: black">Director</FONT></TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD><FONT STYLE="font-size: 10pt; color: black">David Mott</FONT></TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="border-bottom: Black 1px solid"><FONT STYLE="font-size: 10pt; color: black">/s/ Francois Nader</FONT></TD>
    <TD>&nbsp;</TD>
    <TD><FONT STYLE="font-size: 10pt; color: black">Director</FONT></TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD><FONT STYLE="font-size: 10pt; color: black">Francois Nader</FONT></TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="border-bottom: Black 1px solid"><FONT STYLE="font-size: 10pt; color: black">/s/ Jean-Fran&ccedil;ois Pariseau</FONT></TD>
    <TD>&nbsp;</TD>
    <TD><FONT STYLE="font-size: 10pt; color: black">Director</FONT></TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD><FONT STYLE="font-size: 10pt; color: black">Jean-Fran&ccedil;ois Pariseau</FONT></TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
</TABLE>

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<P STYLE="font: 12pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 0; text-align: center"><B>SIGNATURE OF AUTHORIZED
REPRESENTATIVE IN THE UNITED STATES</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify; text-indent: 36pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify; text-indent: 36pt">Pursuant to the requirements
of the Securities Act of 1933, the Registrant&rsquo;s duly authorized representative has signed this Registration Statement on
Form S-8 in the City of Montreal, Canada, on this 4th day of August, 2017.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify; text-indent: 36pt">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
<TR STYLE="vertical-align: bottom">
    <TD STYLE="width: 50%">&nbsp;</TD>
    <TD STYLE="width: 3%"><FONT STYLE="font-size: 10pt; color: black">By</FONT></TD>
    <TD STYLE="width: 37%; border-bottom: black 1px solid"><FONT STYLE="font-size: 10pt; color: black">/s/ Michael Singer</FONT></TD>
    <TD STYLE="width: 10%">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD><FONT STYLE="font-size: 10pt; color: black">Michael Singer</FONT></TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD><FONT STYLE="font-size: 10pt; color: black">Authorized Representative in the United States </FONT></TD>
    <TD>&nbsp;</TD></TR>
</TABLE>



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<P STYLE="font: 12pt Times New Roman, Times, Serif; margin: 0; text-align: center"><B>EXHIBIT INDEX</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-indent: 0.5in">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="width: 100%; font: 10pt Times New Roman, Times, Serif; border-collapse: collapse">
<TR STYLE="vertical-align: bottom">
    <TD STYLE="border-bottom: Black 1px solid; width: 10%; text-align: center"><FONT STYLE="font: 8pt Times New Roman, Times, Serif"><B>Exhibit&nbsp;No.</B>&nbsp;</FONT></TD>
    <TD STYLE="width: 3%"><FONT STYLE="font: 8pt Times New Roman, Times, Serif">&nbsp;</FONT></TD>
    <TD NOWRAP STYLE="width: 87%; text-align: center; border-bottom: Black 1px solid"><FONT STYLE="font: 8pt Times New Roman, Times, Serif"><B>Description</B>&nbsp;</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: center"><FONT STYLE="font-size: 10pt">4.1</FONT></TD>
    <TD>&nbsp;</TD>
    <TD><FONT STYLE="font-size: 10pt">Articles of Amendment of the Registrant (incorporated by reference to Exhibit 3.1&nbsp;&nbsp;to the Registration Statement on Form F-1 (File No.333-219066) filed with the Commission on July 20, 2017)</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: center">4.2</TD>
    <TD>&nbsp;</TD>
    <TD><FONT STYLE="font-size: 10pt">Amended and Restated Bylaws of the Registrant (incorporated by reference to Exhibit 3.2 to the Registration Statement on Form F-1 (File No.333-219066) filed with the Commission on July 20, 2017)</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: center">5.1*</TD>
    <TD>&nbsp;</TD>
    <TD><FONT STYLE="font-size: 10pt">Opinion of Dentons Canada LLP</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: center"><FONT STYLE="font-size: 10pt">23.1*</FONT></TD>
    <TD>&nbsp;</TD>
    <TD><FONT STYLE="font-size: 10pt">Consent of KPMG LLP</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: center"><FONT STYLE="font-size: 10pt">23.2*</FONT></TD>
    <TD>&nbsp;</TD>
    <TD><FONT STYLE="font-size: 10pt">Consent of Dentons Canada LLP (included as part of Exhibit 5.1)</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: center"><FONT STYLE="font-size: 10pt">24.1*</FONT></TD>
    <TD>&nbsp;</TD>
    <TD><FONT STYLE="font-size: 10pt">Power of Attorney (included on the signature pages to this registration statement)</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: center"><FONT STYLE="font-size: 10pt">99.1</FONT></TD>
    <TD>&nbsp;</TD>
    <TD><FONT STYLE="font-size: 10pt">Clementia Pharmaceuticals Inc. Third Amended and Restated Stock Option Plan (incorporated by reference to Exhibit 10.8 to the Registration Statement on Form F-1 (File No.333-219066) filed with the Commission on July 20, 2017)</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: center"><FONT STYLE="font-size: 10pt">99.2</FONT></TD>
    <TD>&nbsp;</TD>
    <TD><FONT STYLE="font-size: 10pt">Clementia Pharmaceuticals Inc. Employee Stock Purchase Plan (incorporated by reference to Exhibit 10.9 to the Registration Statement on Form F-1 (File No.333-219066) filed with the Commission on July 20, 2017)</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: center"><FONT STYLE="font-size: 10pt">99.3</FONT></TD>
    <TD>&nbsp;</TD>
    <TD><FONT STYLE="font-size: 10pt">Clementia Pharmaceuticals Inc. Employee Stock Purchase Plan (incorporated by reference to Exhibit 10.10 to the Registration Statement on Form F-1 (File No.333-219066) filed with the Commission on July 20, 2017)</FONT></TD></TR>
</TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0 0 0 24.45pt; text-indent: -24.5pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0 0 0 24.45pt; text-indent: -24.5pt"></P>

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    <TD STYLE="width: 3%"><FONT STYLE="font-size: 10pt">*</FONT></TD>
    <TD STYLE="width: 97%"><FONT STYLE="font-size: 10pt">Filed herewith. </FONT></TD></TR>
</TABLE>

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[{"type": "S-8", "sequence": "1", "filename": "c89081_s8.htm", "secsgml_size_bytes": 63499}]
{"company-data": {"conformed-name": "Clementia Pharmaceuticals Inc.", "cik": "0001647320", "assigned-sic": "2834", "irs-number": "981128564", "state-of-incorporation": "Z4", "fiscal-year-end": "1231"}, "filing-values": {"form-type": "S-8", "act": "33", "file-number": "333-219703", "film-number": "171008318"}, "business-address": {"street1": "1375 TRANS-CANADA HIGHWAY", "street2": "SUITE 200", "city": "DORVAL", "state": "A8", "zip": "H9P 2W8", "phone": "(514) 940-3600"}, "mail-address": {"street1": "1375 TRANS-CANADA HIGHWAY", "street2": "SUITE 200", "city": "DORVAL", "state": "A8", "zip": "H9P 2W8"}}
As filed with the Securities and Exchange
Commission on August 4, 2017
Registration No. 333-
UNITED STATES
SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM S-8
REGISTRATION STATEMENT
UNDER
THE SECURITIES ACT OF 1933
CLEMENTIA PHARMACEUTICALS INC.
(Exact Name of Registrant as Specified
in its Charter)
Canada
2834
98-1128564
(State or other jurisdiction of
incorporation or organization)
(Primary Standard Industrial
Classification Code Number)
(I.R.S. Employer
Identification No.)
4150 St Catherine Street West, Suite
550
Montreal, Quebec, Canada H3Z 2Y5
(514) 940-3600
(Address, including zip code, and telephone
number, including area code, of Registrant's principal executive offices)
CLEMENTIA PHARMACEUTICALS INC. THIRD
AMENDED AND RESTATED STOCK OPTION PLAN
CLEMENTIA PHARMACEUTICALS INC. 2017 OMNIBUS INCENTIVE PLAN
CLEMENTIA PHARMACEUTICALS INC. EMPLOYEE STOCK PURCHASE PLAN
(Full title of the plan)
The Corporation Trust Company
Corporation Trust Center
1209 Orange Street
Wilmington, DE 19801
Telephone: (302) 658-7581
(Name, address, including zip code, and
telephone number, including area code, of agent for service)
Copies to:
Kevin T. Collins
Martin C. Glass
Jenner & Block LLP
919 Third Avenue
New York, NY 10022
(212) 891-1600
Indicate by check mark whether the registrant
is a large accelerated filer, an accelerated filer, a non-accelerated filer, or a smaller reporting company. See the definitions
of "large accelerated filer," "accelerated filer" and "smaller reporting company" in Rule 12b-2
of the Exchange Act.
Indicate by check mark whether the registrant is an emerging
growth company as defined in Rule 405 of the Securities Act of 1933.
Emerging growth company
x
Large accelerated filer
o
Accelerated filer
o
Non-accelerated filer
x
(Do not check if a smaller reporting company)
Smaller reporting company
o
CALCULATION OF REGISTRATION FEE
Title Of Each Class Of
Securities To Be Registered
Amount
to be
Registered
(1) (2)
Proposed
Maximum
Offering Price
Per Share
Proposed
Maximum
Aggregate
Offering Price
Amount of
Registration Fee
Common Shares, no par value, to be issued under the Clementia Pharmaceuticals Inc. Third Amended and Restated Stock Option Plan (the "Stock Option Plan")
3,786,885
(3)
$16.13
(4)
$61,082,455
(4)
$7,079.46
Common Shares, no par value, to be issued under the Clementia Pharmaceuticals Inc. 2017 Omnibus Incentive Plan (the "Omnibus Plan")
2,339,176
$16.13
(4)
$37,730,909
(4)
$4,373.02
Common Shares, no par value, to be issued under, to be issued under the Clementia Pharmaceuticals Inc. Employee Stock Purchase Plan (the "ESPP")
290,000
$16.13
(4)
$4,677,700
(4)
$542.15
Total
6,416,061
$11,994.63
(1)
Represents common shares of Clementia Pharmaceuticals Inc., no par value ("Common Shares") issuable under the Stock
Option Plan, Omnibus Plan and ESPP.
(2)
Pursuant to Rule 416(a) under the Securities Act of 1933, as amended (the "Securities Act"), this registration statement
also covers an indeterminate number of additional shares that may be offered and issued under the Stock Option Plan, Omnibus Plan
and ESPP to prevent dilution resulting from share dividends, share splits, reverse share splits, recapitalizations, reclassifications,
mergers, split-ups, reorganizations, consolidations and other capital adjustments.
(3)
To be issued under option awards granted under the Stock Option Plan.
(4)
Estimated solely for the purpose of calculating the registration fee in accordance with paragraph (c) and (h) of Rule 457 under
the Securities Act, based on the basis of the average of the high and low prices for the Common Shares on the NASDAQ Global Select
Market on August 3, 2017.
PART I
INFORMATION REQUIRED IN THE SECTION 10(a)
PROSPECTUS
Item 1. Plan Information
The information specified in Item 1 of Part I of Form S-8 is
omitted from this registration statement on Form S-8 in accordance with the provisions of Rule 428 under the Securities Act, and
the introductory note to Part I of Form S-8.
The documents containing the information specified in Part
I of Form S-8 will be delivered to the participants in the Stock Option Plan, the Omnibus Plan and ESPP, as applicable,
covered by this registration statement as specified by Rule 428(b)(1) under the Securities Act. Such documents are not
required to be, and are not, filed with the Securities and Exchange Commission (the "Commission") either as part of this
registration statement or as a prospectus or prospectus supplement pursuant to Rule 424 under the Securities Act.
Item 2. Registrant Information and Employee Plan Annual Information
Upon written or oral request, any of the documents incorporated
by reference in Item 3 of Part II of this Registration Statement (which documents are incorporated by reference in Section 10(a)
of the prospectus) and all documents required to be delivered to employees pursuant to Rule 428(b) under the Securities Act are
available without charge by contacting:
Clementia Pharmaceuticals Inc.
Michael Singer, Chief Financial Officer
4150 St Catherine Street West, Suite 550
Montreal, Quebec, Canada H3Z 2Y5
(514) 940-3610
PART II
INFORMATION REQUIRED IN THE REGISTRATION
STATEMENT
Item 3. Incorporation of Documents by Reference.
The following documents filed with the Commission by Clementia
Pharmaceuticals Inc. (the "Registrant," "we" or "our") pursuant to the Securities Act and the
Securities Exchange Act of 1934, as amended (the "Exchange Act"), are hereby incorporated by reference in this registration
statement:
(a)
The Registrant's prospectus filed with the Commission on August 1, 2017 pursuant to Rule 424(b) of the Securities Act,
relating to the Form F-1 (file number 333-219066); and
(b)
The description of the Registrant's common shares contained in the Registrant's registration statement on Form
8-A filed with the Commission on August 1, 2017, pursuant to Section 12(b) of the Securities Act, including any amendment or report
filed for the purpose of updating such description (file number 333-219066).
All documents that the Registrant subsequently files pursuant
to Sections 13(a), 13(c), 14 and 15(d) of the Exchange Act after the date of this registration statement and prior to the filing
of a post-effective amendment to this registration statement indicating that all securities offered have been sold or which deregisters
all securities then remaining unsold, shall be deemed to be incorporated by reference into this registration statement and to be
a part hereof from the date of filing of such documents; provided, however, that documents or information deemed to have been furnished
and not filed shall not be incorporated by reference into this registration statement.
Any statement contained in a document incorporated or deemed
to be incorporated by reference herein shall be deemed to be modified or superseded for purposes of this registration statement
to the extent that a statement contained herein or in any other subsequently filed document which also is or is deemed to be incorporated
by reference herein modifies or supersedes such statement. Any such statement so modified or superseded shall not be deemed, except
as so modified or superseded, to constitute a part of this registration statement.
Item 4. Description of Securities.
Not applicable.
Item 5. Interests of Named Experts and Counsel.
Not applicable.
Item 6. Indemnification of Directors and Officers.
Section 124 of the Canada Business Corporations Act (the "CBCA")
authorizes corporations to indemnify past and present directors, officers and certain other individuals for the liabilities incurred
in connection with their services as such (including costs, expenses and settlement payments) if such individual acted honestly
and in good faith with a view to the best interest of the corporation and, in the case of a criminal or administrative proceeding,
if such individual had reasonable grounds for believing his or her conduct was lawful. In the case of a suit by or on behalf of
the corporation, a court must approve the indemnification.
The Registrant's bylaws provide that the Registrant shall
indemnify directors and officers.
The Registrant has entered into agreements with its directors
and officers (each an "Indemnitee" under such agreements) to indemnify the Indemnitee, to the extent permitted by law
and subject to certain limitations, against all costs reasonably incurred by an Indemnitee in an action or proceeding to which
the Indemnitee was made a party by reason of the Indemnitee being an officer or director of (i) the Registrant or (ii) an organization
of which the Registrant is a shareholder or creditor if the Indemnitee serves such organization at the Registrant's request.
The Registrant maintains insurance policies relating to certain
liabilities that the Registrant's directors and officers may incur in such capacity.
The Registrant has entered into indemnity agreements with its
directors and certain officers which provide, among other things, that the Registrant will indemnify each such individual to the
fullest extent permitted by law and as permitted by the CBCA from and against all liabilities, costs, charges and expenses that
he or she may incur as a result of his or her actions in the exercise of his or her duties as director or officer, provided that
the Registrant shall not indemnify such individual if, among other things, he or she did not act honestly and in good faith with
a view to our best interests and, in the case of a criminal or administrative action or proceeding that is enforced by a monetary
penalty, the individual had reasonable grounds for believing that his or her conduct was lawful.
Item 7. Exemption from Registration Claimed.
Not applicable.
Item 8. Exhibits.
The following exhibits are filed
or incorporated by reference as part of this registration statement:
Exhibit No.
Description
4.1
Articles of Amendment of the Registrant (incorporated by reference to Exhibit 3.1  to
    the Registration Statement on Form F-1 (File No.333-219066) filed with the Commission on July 20, 2017)
4.2
Amended and Restated Bylaws of the Registrant (incorporated by reference to Exhibit 3.2 to the Registration Statement on Form F-1 (File No.333-219066) filed with the Commission on July 20, 2017)
5.1*
Opinion of Dentons Canada LLP
23.1*
Consent of KPMG LLP
23.2*
Consent of Dentons Canada LLP (included as part of Exhibit 5.1)
24.1*
Power of Attorney (included on the signature pages to this registration statement)
99.1
Clementia Pharmaceuticals Inc. Third Amended and Restated Stock Option Plan (incorporated by reference to Exhibit 10.8 to the Registration Statement on Form F-1 (File No.333-219066) filed with the Commission on July 20, 2017)
99.2
Clementia Pharmaceuticals Inc. Employee Stock Purchase Plan (incorporated by reference to Exhibit 10.9 to the Registration Statement on Form F-1 (File No.333-219066) filed with the Commission on July 20, 2017)
99.3
Clementia Pharmaceuticals Inc. Employee Stock Purchase Plan (incorporated by reference to Exhibit 10.10 to the Registration Statement on Form F-1 (File No.333-219066) filed with the Commission on July 20, 2017)
*
Filed herewith.
Item 9. Undertakings.
(a)
The undersigned Registrant hereby undertakes:
(1)
To file, during any period in which offers or sales are being made, a post-effective amendment to this registration statement:
(i)
To include any prospectus required by Section 10(a)(3) of the Securities Act;
(ii)
To reflect in the prospectus any facts or events arising after the effective date of the registration statement (or the most
recent post-effective amendment thereof) which, individually or in the aggregate, represent a fundamental change in the information
set forth in the registration statement. Notwithstanding the foregoing, any increase or decrease in volume of securities offered
(if the total dollar value of securities offered would not exceed that which was registered) and any deviation from the low or
high end of the estimated maximum offering range may be reflected in the form of prospectus filed with the Commission pursuant
to Rule 424(b) if, in the aggregate, the changes in volume and price represent no more than a 20 percent change in the maximum
aggregate offering price set forth in the "Calculation of Registration Fee" table in the effective registration statement;
and
(iii)
To include any material information with respect to the plan of distribution not previously disclosed in the registration statement
or any material change to such information in the registration statement;
provided, however
, that paragraphs (a)(1)(i)
and (a)(1)(ii) above do not apply if the information required to be included in a post- effective amendment by those paragraphs
is contained in reports filed with or furnished to the Commission by the Registrant pursuant to Section 13 or Section 15(d) of
the Exchange Act that are incorporated by reference in this registration statement.
(2) that, for the purpose of determining any liability
under the Securities Act, each such post- effective amendment shall be deemed to be a new registration statement relating to the
securities offered therein, and the offering of such securities at that time shall be deemed to be the initial
bona fide
offering
thereof.
(3) to remove from registration by means of a post-
effective amendment any of the securities being registered which remain unsold at the termination of the offering.
(b)
The undersigned Registrant hereby undertakes that, for purposes of determining any liability under the Securities Act, each
filing of the Registrant's annual report pursuant to Section 13(a) or 15(d) of the Exchange Act (and, where applicable, each
filing of an employee benefit plan's annual report pursuant to Section 15(d) of the Exchange Act) that is incorporated by
reference in the registration statement shall be deemed to be a new registration statement relating to the securities offered therein,
and the offering of such securities at that time shall be deemed to be the initial
bona fide
offering thereof.
(c)
Insofar as indemnification for liabilities arising under the Securities Act may be permitted to directors, officers and
                                                          controlling persons of the Registrant pursuant to the foregoing provisions, or otherwise, the Registrant has been advised
                                                          that in the opinion of the Commission such indemnification
is against public policy as expressed in the Securities Act, and is, therefore, unenforceable. In the event that a claim for indemnification
against such liabilities (other than the payment by the Registrant of expenses incurred or paid by a director, officer or controlling
person of the Registrant in the successful defense of any action, suit or proceeding) is asserted by such director, officer or
controlling person in connection with the securities being registered, the Registrant will, unless in the opinion of its counsel
the matter has been settled by controlling precedent, submit to a court of appropriate jurisdiction the question whether such indemnification
by it is against public policy as expressed in the Securities Act and will be governed by the final adjudication of such issue.
SIGNATURES
Pursuant to the requirements
of the Securities Act, the Registrant certifies that it has reasonable grounds to believe that it meets all of the requirements
for filing on Form S-8 and has duly caused this Registration Statement to be signed on its behalf by the undersigned, thereunto
duly authorized, in the City of Montreal, Canada, on this 4th day of August, 2017.
CLEMENTIA PHARMACEUTICALS INC.
By
/s/ Michael Singer
Michael Singer
Chief Financial Officer
POWER OF ATTORNEY
KNOW ALL PERSONS BY THESE
PRESENTS, that each person whose signature appears below hereby constitutes and appoints Clarissa Desjardins and Michael Singer
as the undersigned's true and lawful attorneys-in-fact and agents, with full powers of substitution and resubstitution, for
such person and in such person's name, place and stead, in any and all capacities, to sign any and all amendments (including
pre-effective and post-effective amendments) to this registration statement and to file the same, with all exhibits thereto and
other documents in connection therewith, with the Securities and Exchange Commission, granting unto such attorneys-in-fact and
agents, full power and authority to do and perform each and every act and thing requisite or necessary to be done in and about
the premises, as fully to all intents and purposes as such person might or could do in person, hereby ratifying and confirming
all that such attorneys-in-fact and agents, or their substitute or substitutes, may lawfully do or cause to be done by virtue hereof.
Pursuant to the requirements
of the Securities Act, this Registration Statement has been signed below by the following persons in the capacities indicated on
this 4th day of August, 2017.
Signature
Title
/s/ Clarissa Desjardins
Chief Executive Officer and Director (Principal
Clarissa Desjardins
Executive Officer)
/s/ Michael Singer
Chief Financial Officer (Principal Financial
Michael Singer
Officer and Principal Accounting Officer)
/s/ David P. Bonita
Chairman of the Board of Directors
David P. Bonita
/s/ Robert Heft
Director
Robert Heft
/s/ Allan Mandelzys
Director
Allan Mandelzys
/s/ David Mott
Director
David Mott
/s/ Francois Nader
Director
Francois Nader
/s/ Jean-François Pariseau
Director
Jean-François Pariseau
SIGNATURE OF AUTHORIZED
REPRESENTATIVE IN THE UNITED STATES
Pursuant to the requirements
of the Securities Act of 1933, the Registrant's duly authorized representative has signed this Registration Statement on
Form S-8 in the City of Montreal, Canada, on this 4th day of August, 2017.
By
/s/ Michael Singer
Michael Singer
Authorized Representative in the United States
EXHIBIT INDEX
Exhibit No.
Description
4.1
Articles of Amendment of the Registrant (incorporated by reference to Exhibit 3.1  to the Registration Statement on Form F-1 (File No.333-219066) filed with the Commission on July 20, 2017)
4.2
Amended and Restated Bylaws of the Registrant (incorporated by reference to Exhibit 3.2 to the Registration Statement on Form F-1 (File No.333-219066) filed with the Commission on July 20, 2017)
5.1*
Opinion of Dentons Canada LLP
23.1*
Consent of KPMG LLP
23.2*
Consent of Dentons Canada LLP (included as part of Exhibit 5.1)
24.1*
Power of Attorney (included on the signature pages to this registration statement)
99.1
Clementia Pharmaceuticals Inc. Third Amended and Restated Stock Option Plan (incorporated by reference to Exhibit 10.8 to the Registration Statement on Form F-1 (File No.333-219066) filed with the Commission on July 20, 2017)
99.2
Clementia Pharmaceuticals Inc. Employee Stock Purchase Plan (incorporated by reference to Exhibit 10.9 to the Registration Statement on Form F-1 (File No.333-219066) filed with the Commission on July 20, 2017)
99.3
Clementia Pharmaceuticals Inc. Employee Stock Purchase Plan (incorporated by reference to Exhibit 10.10 to the Registration Statement on Form F-1 (File No.333-219066) filed with the Commission on July 20, 2017)
*
Filed herewith.