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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>As filed with the Securities and Exchange
Commission on March 22, 2018</B></P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: right"><B>Registration
No. 333-______</B></P>

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<P STYLE="font: 14pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">UNITED STATES</P>

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<P STYLE="font: 14pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">SECURITIES AND EXCHANGE COMMISSION</P>

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<P STYLE="font: 13pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">Washington, D.C. 20549</P>

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<P STYLE="font: 14pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">FORM S-8</P>

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<P STYLE="font: 11pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">REGISTRATION STATEMENT<BR>
UNDER THE SECURITIES ACT OF 1933</P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">____________________</P>



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<P STYLE="font: 14pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">Auris Medical Holding AG</P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">(Exact Name of Registrant as Specified in
Its Charter)</P>

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    <TD STYLE="width: 34%; text-align: center"><B>Switzerland</B></TD>
    <TD STYLE="width: 33%; text-align: center">&nbsp;</TD>
    <TD STYLE="width: 33%; text-align: center"><B>Not Applicable</B></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: center"><FONT STYLE="font-size: 10pt">(State or Other Jurisdiction of </FONT><BR>
<FONT STYLE="font-size: 10pt">Incorporation or Organization)</FONT></TD>
    <TD STYLE="text-align: center">&nbsp;</TD>
    <TD STYLE="text-align: center"><FONT STYLE="font-size: 10pt">(I.R.S. Employer</FONT><BR>
<FONT STYLE="font-size: 10pt">Identification Number)</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD STYLE="text-align: center"><B>Bahnhofstrasse 21</B><BR>
<B>6300 Zug</B><BR>
<B>Switzerland</B></TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD COLSPAN="3" STYLE="text-align: center"><P STYLE="margin-top: 0; margin-bottom: 0"><FONT STYLE="font-size: 10pt">(Address,
Including Zip Code of Principal Executive Offices)</FONT></P>
                                               <P STYLE="margin-top: 0; margin-bottom: 0"><P STYLE="font: 13pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">____________________</P>



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&nbsp;</P></TD></TR>
</TABLE>


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    <TD STYLE="width: 100%">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>Auris Medical Holding AG Equity Incentive
        Plan, as amended</B></P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"></P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>Auris Medical Holding AG Stock Option
        Plan A</B></P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"></P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>Auris Medical Holding AG Stock Option
        Plan C</B></P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"></P></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: center"><FONT STYLE="font-size: 10pt">(Full title of Plans)</FONT></TD></TR>
</TABLE>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">____________________</P>



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    <TD STYLE="width: 100%">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>&nbsp;</B></P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>Cogency Global, Inc.</B></P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"></P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>10 East 40<SUP>th</SUP> Street, 10th
        Floor</B><BR>
        <B>New York, New York 10016</B><BR>
        <B>(212) 947-7200</B></P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"></P></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="font-size: 10pt; text-align: center"><FONT STYLE="font-size: 10pt">(Name, address and telephone number, including area code, of agent for service)</FONT></TD></TR>
</TABLE>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">____________________</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>



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    <TD STYLE="width: 34%; font-size: 10pt">&nbsp;</TD>
    <TD STYLE="width: 33%; font-size: 10pt; text-align: center"><B><I>Copies to:</I></B></TD>
    <TD STYLE="width: 33%; font-size: 10pt">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="font-size: 10pt; text-align: center">&nbsp;</TD>
    <TD>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>Sophia Hudson</B>&nbsp;</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>Davis Polk &amp; Wardwell LLP</B></P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;<B>450 Lexington Avenue</B></P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"></P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>New York, New York 10017</B></P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"></P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>(212) 450-4000</B>&nbsp;</P></TD>
    <TD STYLE="font-size: 10pt; text-align: center">&nbsp;</TD></TR>
</TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">Indicate by check mark whether the registrant
is a large accelerated filer, an accelerated filer, a non-accelerated filer, or a smaller reporting company. See the definitions
of &ldquo;large accelerated filer,&rdquo; &ldquo;accelerated filer&rdquo; and &ldquo;smaller reporting company&rdquo; in Rule 12b-2
of the Exchange Act.</P>

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<TR STYLE="vertical-align: top">
    <TD STYLE="width: 63%; font-size: 10pt; text-indent: 0in; padding-left: 0.5in"><FONT STYLE="font-size: 10pt">Large accelerated filer&nbsp;&nbsp;<FONT STYLE="font-family: Times New Roman, Times, Serif">&#9744;</FONT></FONT></TD>
    <TD STYLE="width: 37%; font-size: 10pt; text-indent: 0in"><FONT STYLE="font-size: 10pt">Accelerated filer&nbsp;&nbsp;<FONT STYLE="font-family: Times New Roman, Times, Serif">&#9744;</FONT></FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="font-size: 10pt; text-indent: 0in; padding-left: 0.5in"><FONT STYLE="font-size: 10pt">Non-accelerated filer&nbsp;&nbsp;<FONT STYLE="font-family: Times New Roman, Times, Serif">&#9746;</FONT>&nbsp;&nbsp;(Do not check if a smaller reporting company)</FONT></TD>
    <TD STYLE="font-size: 10pt; text-indent: 0in"><FONT STYLE="font-size: 10pt">Smaller reporting company&nbsp;&nbsp;<FONT STYLE="font-family: Times New Roman, Times, Serif">&#9744;</FONT></FONT></TD></TR>
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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">____________________</P>



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<TR STYLE="vertical-align: bottom">
    <TD COLSPAN="5" STYLE="border-bottom: Black 2.5pt double; text-align: center"><FONT STYLE="font-size: 10pt"><B>CALCULATION OF REGISTRATION FEE</B></FONT></TD></TR>
<TR STYLE="vertical-align: bottom">
    <TD STYLE="width: 47%; border-bottom: Black 1pt solid; border-right: Black 1pt solid; text-align: center; font-weight: bold">Title Of Securities To Be Registered</TD>
    <TD STYLE="width: 11%; border-bottom: Black 1pt solid; border-right: Black 1pt solid; text-align: center; font-weight: bold">Amount To Be Registered(1)</TD>
    <TD STYLE="width: 15%; border-bottom: Black 1pt solid; border-right: Black 1pt solid; text-align: center; font-weight: bold">Proposed Maximum Offering Price Per Share</TD>
    <TD STYLE="width: 13%; border-bottom: Black 1pt solid; border-right: Black 1pt solid; text-align: center; font-weight: bold">Proposed Maximum Aggregate Offering Price</TD>
    <TD STYLE="width: 14%; border-bottom: Black 1pt solid; text-align: center; font-weight: bold">Amount Of<BR>
Registration Fee</TD></TR>
<TR STYLE="vertical-align: bottom">
    <TD STYLE="border-right: Black 1pt solid; border-bottom: Black 1pt solid; padding-left: 0.125in; text-indent: -0.125in">Common Shares, nominal value CHF 0.02 per share, reserved for issuance pursuant to stock option awards outstanding under the EIP, Plan&nbsp;A and Plan C&#9;</TD>
    <TD STYLE="border-right: Black 1pt solid; border-bottom: Black 1pt solid; text-align: center">220,154</TD>
    <TD STYLE="border-right: Black 1pt solid; border-bottom: Black 1pt solid; text-align: center">$16.70(2)</TD>
    <TD STYLE="border-right: Black 1pt solid; border-bottom: Black 1pt solid; text-align: center">$3,676,571.80(2)</TD>
    <TD STYLE="border-bottom: Black 1pt solid; text-align: center">$457.73(2)</TD></TR>
<TR STYLE="vertical-align: bottom">
    <TD STYLE="border-right: Black 1pt solid; border-bottom: Black 1pt solid; padding-left: 0.125in; text-indent: -0.125in">Common Shares, nominal value CHF 0.02 per share, reserved for issuance pursuant to the EIP, Plan A and Plan C&#9;</TD>
    <TD STYLE="border-right: Black 1pt solid; border-bottom: Black 1pt solid; text-align: center">694,846</TD>
    <TD STYLE="border-right: Black 1pt solid; border-bottom: Black 1pt solid; text-align: center">$1.48(3)</TD>
    <TD STYLE="border-right: Black 1pt solid; border-bottom: Black 1pt solid; text-align: center">$1,028,372.08(3)</TD>
    <TD STYLE="border-bottom: Black 1pt solid; text-align: center">$128.03(3)</TD></TR>
<TR STYLE="vertical-align: bottom">
    <TD STYLE="border-right: Black 1pt solid; border-bottom: Black 1pt solid"><B>Total Common Shares </B></TD>
    <TD STYLE="border-right: Black 1pt solid; border-bottom: Black 1pt solid; text-align: center">915,000</TD>
    <TD STYLE="border-right: Black 1pt solid; border-bottom: Black 1pt solid; text-align: center">N/A</TD>
    <TD STYLE="border-right: Black 1pt solid; border-bottom: Black 1pt solid; text-align: center">$4,704,943.88</TD>
    <TD STYLE="border-bottom: Black 1pt solid; text-align: center">$585.77</TD></TR>
</TABLE>
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<TD STYLE="width: 0"></TD><TD STYLE="width: 0.25in">(1)</TD><TD>This Registration Statement on Form S-8 (this &ldquo;Registration Statement&rdquo;) covers (i) common shares, nominal value
CHF 0.02 per share (&ldquo;Common Shares&rdquo;), of Auris Medical Holding AG (the &ldquo;Registrant&rdquo;) issuable pursuant
to (x) the Auris Medical Holding AG Equity Incentive Plan, as amended (the &ldquo;EIP&rdquo;) assumed by the Registrant in connection
with the Merger (as defined in the Explanatory Statement below) and registered by Old Auris Medical Holding AG (as defined in the
Explanatory Statement below) prior to the Merger on two Registration Statements on Form S-8 (File Nos. 333-200805 and 333-217306)
filed with the U.S. Securities and Exchange Commission (the &ldquo;Commission&rdquo;) on December 8, 2014 and April 14, 2017, and
(y) the Auris Medical Holding AG Stock Option Plan A, as amended (&ldquo;Plan A&rdquo;) and Auris Medical Holding AG Stock Option
Plan C (&ldquo;Plan C&rdquo;) (Plan A and Plan C, and together with the EIP, the &ldquo;Plans&rdquo;) assumed by the Registrant
in connection with the Merger and registered by Old Auris Medical Holding AG prior to the Merger on one Registration Statement
on Form S-8 (File No. 333-198037), filed with the Commission on August 11, 2014; and (ii) pursuant to Rule 416(a) under the Securities
Act of 1933, as amended (the &ldquo;Securities Act&rdquo;), any additional Common Shares that become issuable under the Plans by
reason of any share dividend, share split or other similar transaction.</TD></TR></TABLE>

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<TD STYLE="width: 0"></TD><TD STYLE="width: 0.25in">(2)</TD><TD>Estimated pursuant to Rule 457(h) and Rule 457(c) under the Securities Act, solely for the purpose of computing the registration
fee, based on the weighted average exercise price of the stock options outstanding under the applicable Plan.</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif"></P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0"></TD><TD STYLE="width: 0.25in">(3)</TD><TD>Estimated pursuant to Rule 457(h) and Rule 457(c) under the Securities Act, solely for the purpose of computing the registration
fee for Common Shares to be issued pursuant to the Plans, based on the average of the high and low prices reported for a Common
Share on the NASDAQ Capital Market on March 16, 2018.</TD></TR></TABLE>

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<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">EXPLANATORY NOTE</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">On March 13, 2018, old Auris Medical Holding
AG (&ldquo;Old Auris Medical Holding AG&rdquo;) merged (the &ldquo;Merger&rdquo;) into Auris Medical NewCo Holding AG, a newly
incorporated, wholly-owned Swiss subsidiary (&ldquo;Auris NewCo&rdquo;) following shareholder approval at an extraordinary general
meeting of shareholders held on the same day. Following the Merger, Auris NewCo, the surviving company had a share capital of CHF&nbsp;122,347.76,
divided into 6,117,388 common shares with a nominal value of CHF 0.02 each. Pursuant to the Merger, the shareholders of Old Auris
Medical Holding AG received one common share with a nominal value of CHF 0.02 of Auris NewCo for every 10 of Old Auris Medical
Holding AG common shares held prior to the Merger, effectively resulting in a &ldquo;reverse share split&rdquo; at a ratio of 10-for-1.
Auris NewCo changed its name to Auris Medical Holding AG in connection with the closing of the Merger and as a result, future filings
with the Commission are being made under the name Auris Medical Holding AG, which is the Registrant. On March 14, 2018 the common
shares of Auris NewCo began trading on the Nasdaq Capital Market under the trading symbol &ldquo;EARS&rdquo;.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">PART I</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">INFORMATION REQUIRED IN THE SECTION
10(a) PROSPECTUS</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">The documents containing the information
specified in Item 1 and Item 2 of Part I of Form S-8 will be delivered to participants as specified by Rule 428(b)(1) under the
Securities Act. In accordance with the rules and regulations of the Commission and the instructions to Form S-8, such documents
are not being filed with the Commission either as part of this Registration Statement or as prospectuses or prospectus supplements
pursuant to Rule 424 under the Securities Act.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">PART II</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">INFORMATION REQUIRED IN THE REGISTRATION
STATEMENT</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">Item 3. Incorporation of Documents by Reference.</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">The following documents are incorporated
herein by reference:</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">(a)&nbsp;&nbsp;The
Registrant&rsquo;s Annual Report on Form 20-F for the fiscal year ended December 31, 2017, filed with the Commission on March 22,
2018.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">(b)&nbsp;&nbsp;All
reports filed pursuant to Section 13(a) or 15(d) of the Securities Exchange Act of 1934, as amended (the &ldquo;Exchange Act&rdquo;),
since December 31, 2017.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">(c) &nbsp;The description of the Registrant&rsquo;s
Common Shares which is contained in the predecessor to the Registrant&rsquo;s Exchange Act Registration Statement on Form 8-A, dated July 29, 2014 and amended on June 1, 2016, including any amendments or supplements thereto or report
filed for the purpose of updating such description.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">In addition, all documents subsequently
filed by the Registrant with the Commission pursuant to Sections 13(a), 13(c), 14 and 15(d) of the Exchange Act, prior to the filing
of a post-effective amendment to this Registration Statement which indicates that all securities offered have been sold or which
deregisters all securities then remaining unsold, shall be deemed to be incorporated by reference in this Registration Statement
and to be a part hereof from the date of the filing of such documents.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">Any statement contained in a document incorporated
or deemed to be incorporated by reference herein shall be deemed to be modified or superseded for purposes of this Registration
Statement to the extent that a statement contained herein (or in any other subsequently filed document which also is incorporated
or deemed to be incorporated by reference herein) modifies or supersedes such statement. Any such statement so modified or superseded
shall not be deemed, except as so modified or superseded, to constitute a part of this Registration Statement.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">Item 4. Description of Securities.</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">Not applicable.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>


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<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">Item 5. Interests of Named Experts and Counsel.</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">Not applicable.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">Item 6. Indemnification of Directors and Officers.</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">Under Swiss law, a corporation may indemnify
its directors or officers against losses and expenses (except for such losses and expenses arising from willful misconduct or negligence,
although legal scholars advocate that at least gross negligence be required), including attorney&rsquo;s fees, judgments, fines
and settlement amounts actually and reasonably incurred in a civil or criminal action, suit or proceeding by reason of having been
the representative of, or serving at the request of, the corporation.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">Subject to Swiss law, Article 17 of the
Registrant&rsquo;s articles of association provides for indemnification of the existing and former members of our board of directors,
executive management, and their heirs, executors and administrators, against liabilities arising in connection with the performance
of their duties in such capacity, and permits the Registrant to advance the expenses of defending any act, suit or proceeding to
members of the Registrant&rsquo;s board of directors and executive management.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">In addition, under general principles of
Swiss employment law, an employer may be required to indemnify an employee against losses and expenses incurred by such employee
in the proper execution of their duties under the employment agreement with the company.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">The Registrant has entered into indemnification
agreements with each of the members of our board of directors and executive officers in the form filed as Exhibit 99.4 to the Registrant&rsquo;s
Form 6-K filed with the Commission on May 11, 2016.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">Insofar as indemnification for liabilities
arising under the Securities Act of 1933, as amended, may be permitted to directors, officers and controlling persons of the Registrant,
the Registrant has been advised that, in the opinion of the Securities and Exchange Commission, such indemnification is against
public policy as expressed in the Securities Act of 1933, as amended, and is, therefore, unenforceable.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">Item 7. Exemption from Registration Claimed</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">Not Applicable.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">Item 8. Exhibits.</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
<TR STYLE="vertical-align: bottom">
    <TD STYLE="width: 9%; border-bottom: Black 1pt solid; text-align: center; font-weight: bold">Exhibit Number</TD>
    <TD STYLE="width: 91%; text-align: center; font-weight: bold; padding-left: 3pt">&nbsp;</TD></TR>
<TR>
    <TD STYLE="vertical-align: top; text-align: center; padding-top: 4pt; padding-bottom: 4pt"><A HREF="http://www.sec.gov/Archives/edgar/data/1601936/000160193618000007/exhibit11.htm">4.1</A></TD>
    <TD STYLE="vertical-align: bottom; padding-top: 4pt; padding-bottom: 4pt; padding-left: 3pt"><A HREF="http://www.sec.gov/Archives/edgar/data/1601936/000160193618000007/exhibit11.htm">Articles of Association of Auris Medical Holding AG (incorporated by reference to exhibit 1.1 of the Registration Statement on Form 20-F filed with the Commission on March 22, 2018)</A></TD></TR>
<TR>
    <TD STYLE="vertical-align: top; text-align: center; padding-top: 4pt; padding-bottom: 4pt"><A HREF="http://www.sec.gov/Archives/edgar/data/1601936/000119312514273405/d684505dex41.htm">4.2</A></TD>
    <TD STYLE="vertical-align: bottom; padding-top: 4pt; padding-bottom: 4pt; padding-left: 3pt"><A HREF="http://www.sec.gov/Archives/edgar/data/1601936/000119312514273405/d684505dex41.htm">Form of Registration Rights Agreement (incorporated herein by reference to Exhibit 4.1 to the Registrant&rsquo;s Registration Statement on Form F-1/A, filed with the Commission on July 21, 2014 (Registration File No. 333-197105))</A></TD></TR>
<TR>
    <TD STYLE="vertical-align: top; text-align: center; padding-top: 4pt; padding-bottom: 4pt"><A HREF="dp88274_ex05.htm">5</A></TD>
    <TD STYLE="vertical-align: bottom; padding-top: 4pt; padding-bottom: 4pt; padding-left: 3pt"><A HREF="dp88274_ex05.htm">Opinion of Walder Wyss Ltd., Swiss counsel to the Registrant (filed herewith)</A></TD></TR>
<TR>
    <TD STYLE="vertical-align: top; text-align: center; padding-top: 4pt; padding-bottom: 4pt"><A HREF="dp88274_ex2301.htm">23.1</A></TD>
    <TD STYLE="vertical-align: bottom; padding-top: 4pt; padding-bottom: 4pt; padding-left: 3pt"><A HREF="dp88274_ex2301.htm">Consent of Deloitte AG (filed herewith)</A></TD></TR>
<TR>
    <TD STYLE="vertical-align: top; text-align: center; padding-top: 4pt; padding-bottom: 4pt"><A HREF="dp88274_ex05.htm">23.2</A></TD>
    <TD STYLE="vertical-align: bottom; padding-top: 4pt; padding-bottom: 4pt; padding-left: 3pt"><A HREF="dp88274_ex05.htm">Consent of Walder Wyss Ltd., Swiss counsel to the Registrant (included in Exhibit 5) </A></TD></TR>
<TR>
    <TD STYLE="vertical-align: top; text-align: center; padding-top: 4pt; padding-bottom: 4pt"><A HREF="#ex24">24</A></TD>
    <TD STYLE="vertical-align: bottom; padding-top: 4pt; padding-bottom: 4pt; padding-left: 3pt"><A HREF="#ex24">Power of Attorney (included in the signature pages hereof)</A></TD></TR>
<TR>
    <TD STYLE="vertical-align: top; text-align: center; padding-top: 4pt; padding-bottom: 4pt"><A HREF="dp88274_ex9901.htm">99.1</A></TD>
    <TD STYLE="vertical-align: bottom; padding-top: 4pt; padding-bottom: 4pt; padding-left: 3pt"><A HREF="dp88274_ex9901.htm">Auris Medical Holding AG Equity Incentive Plan, as amended (filed herewith)</A></TD></TR>
<TR>
    <TD STYLE="vertical-align: top; text-align: center; padding-top: 4pt; padding-bottom: 4pt"><A HREF="dp88274_ex9902.htm">99.2</A></TD>
    <TD STYLE="vertical-align: bottom; padding-top: 4pt; padding-bottom: 4pt; padding-left: 3pt"><A HREF="dp88274_ex9902.htm">Auris Medical Holding AG Stock Option Plan A, as amended (filed herewith)</A></TD></TR>
<TR>
    <TD STYLE="vertical-align: top; text-align: center; padding-top: 4pt; padding-bottom: 4pt"><A HREF="dp88274_ex9903.htm">99.3</A></TD>
    <TD STYLE="vertical-align: bottom; padding-top: 4pt; padding-bottom: 4pt; padding-left: 3pt"><A HREF="dp88274_ex9903.htm">Amendment to Auris Medical Holding AG Stock Option Plan A (filed herewith)</A></TD></TR>
<TR>
    <TD STYLE="vertical-align: top; text-align: center; padding-top: 4pt; padding-bottom: 4pt"><A HREF="dp88274_ex9904.htm">99.4 </A></TD>
    <TD STYLE="vertical-align: bottom; padding-top: 4pt; padding-bottom: 4pt; padding-left: 3pt"><A HREF="dp88274_ex9904.htm">Auris Medical Holdings AG Stock Option Plan C (filed herewith)</A></TD></TR>
</TABLE>

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<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">Item 9. Undertakings.</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">(a)&nbsp;&nbsp;The undersigned Registrant
hereby undertakes:</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">(1)&nbsp;&nbsp;To file, during any period
in which offers or sales are being made, a post-effective amendment to this Registration Statement:</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.25in; text-indent: 0.25in">(i)&nbsp;&nbsp;To include any
prospectus required by Section 10(a)(3) of the Securities Act;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.25in; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.25in; text-indent: 0.25in">(ii)&nbsp; To reflect in the
prospectus any facts or events arising after the effective date of this Registration Statement (or the most recent post-effective
amendment thereof) which, individually or in the aggregate, represent a fundamental change in the information set forth in this
Registration Statement. Notwithstanding the foregoing, any increase or decrease in volume of securities offered (if the total dollar
value of securities offered would not exceed that which was registered) and any deviation from the low or high end of the estimated
maximum offering range may be reflected in the form of prospectus filed with the Commission pursuant to Rule 424(b) if, in the
aggregate, the changes in volume and price represent no more than a 20 percent change in the maximum aggregate offering price set
forth in the &ldquo;Calculation of Registration Fee&rdquo; table in the effective Registration Statement;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.25in; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.25in; text-indent: 0.25in">(iii)&nbsp;&nbsp;To include
any material information with respect to the Plans not previously disclosed in this Registration Statement or any material change
to such information in this Registration Statement;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.25in; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><I>provided</I>,&nbsp;<I>however</I>, that paragraphs (a)(1)(i)
and (a)(1)(ii) do not apply if the information required to be included in a post-effective amendment by those paragraphs is contained
in periodic reports filed with or furnished to the Commission by the Registrant pursuant to Section 13 or 15(d) of the Exchange
Act that are incorporated by reference in this Registration Statement.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">(2)&nbsp;&nbsp;That, for the purpose of
determining any liability under the Securities Act, each such post-effective amendment shall be deemed to be a new registration
statement relating to the securities offered therein, and the offering of such securities at that time shall be deemed to be the
initial <I>bona fide</I> offering thereof.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">(3)&nbsp;&nbsp;To remove from registration
by means of a post-effective amendment any of the securities being registered which remain unsold at the termination of the offering.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">(4) To file a post-effective amendment
to the registration statement to include any financial statements required by Item 8.A. of Form 20-F at the start of any delayed
offering or throughout a continuous offering. Financial statements and information otherwise required by Section 10(a)(3) of the
Act need not be furnished, provided that the registrant includes in the prospectus, by means of a post-effective amendment, financial
statements required pursuant to this paragraph (a)(4) and other information necessary to ensure that all other information in the
prospectus is at least as current as the date of those financial statements. Notwithstanding the foregoing, with respect to registration
statements on Form F-3, a post-effective amendment need not be filed to include financial statements and information required by
Section 10(a)(3) of the Act or Rule 3-19 of this chapter if such financial statements and information are contained in periodic
reports filed with or furnished to the Commission by the registrant pursuant to section 13 or section 15(d) of the Securities Exchange
Act of 1934 that are incorporated by reference in the Form F-3.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">(b)&nbsp;&nbsp;The undersigned Registrant
hereby undertakes that, for purposes of determining any liability under the Securities Act, each filing of the Registrant&rsquo;s
annual report pursuant to Section 13(a) or 15(d) of the Exchange Act (and, where applicable, each filing of an employee benefit
plan&rsquo;s annual report pursuant to Section 15(d) of the Exchange Act) that is incorporated by reference in this Registration
Statement shall be deemed to be a new registration statement relating to the securities offered therein, and the offering of such
securities at that time shall be deemed to be the initial&nbsp;<I>bona fide</I>&nbsp;offering thereof.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>


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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">(c)&nbsp;&nbsp;Insofar as indemnification
for liabilities arising under the Securities Act may be permitted to directors, officers and controlling persons of the Registrant
pursuant to the foregoing provisions, or otherwise, the Registrant has been advised that in the opinion of the Commission such
indemnification is against public policy as expressed in the Securities Act and is, therefore, unenforceable.&nbsp;&nbsp;In the
event that a claim for indemnification against such liabilities (other than the payment by the Registrant of expenses incurred
or paid by a director, officer or controlling person of the Registrant in the successful defense of any action, suit or proceeding)
is asserted by such director, officer or controlling person in connection with the securities being registered, the Registrant
will, unless in the opinion of its counsel the matter has been settled by controlling precedent, submit to a court of appropriate
jurisdiction the question whether such indemnification by it is against public policy as expressed in the Securities Act and will
be governed by the final adjudication of such issue.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>


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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><FONT STYLE="text-transform: uppercase"><B>Signatures</B></FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">Pursuant to the requirements of the Securities
Act of 1933, the Registrant certifies that it has reasonable grounds to believe that it meets all of the requirements for filing
this Registration Statement and has duly caused this Registration Statement to be signed on its behalf by the undersigned, thereunto
duly authorized, in Zug, Switzerland on this 22nd day of March, 2018.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="width: 100%; font: 10pt Times New Roman, Times, Serif; border-collapse: collapse">
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD COLSPAN="2">Auris Medical Holding AG</TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD COLSPAN="2">&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD COLSPAN="2">&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="width: 55%">&nbsp;</TD>
    <TD STYLE="width: 5%">By:</TD>
    <TD STYLE="width: 25%; border-bottom: Black 1pt solid">/s/ Thomas Meyer</TD>
    <TD STYLE="width: 15%">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>Name:&#9;Thomas Meyer</TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>Title:&#9;&nbsp;&nbsp;Chief Executive Officer</TD>
    <TD>&nbsp;</TD></TR>
</TABLE>

<P STYLE="margin-top: 0; margin-bottom: 0">&nbsp;</P>

<P STYLE="margin-top: 0; margin-bottom: 0">&nbsp;</P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; text-indent: 0.25in"><B><A NAME="ex24"></A>POWER OF ATTORNEY</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">KNOW ALL PERSONS BY THESE PRESENTS, that
each person whose signature appears below hereby constitutes and appoints Thomas Meyer, Hernan Levett and Raoul Dias and each of
them, individually, as his or her true and lawful attorneys-in-fact and agents, with full power of substitution and resubstitution,
for him or her and in his or her name, place and stead in any and all capacities, in connection with this Registration Statement,
including to sign in the name and on behalf of the undersigned, this Registration Statement and any and all amendments thereto,
including post-effective amendments and registrations filed pursuant to Rule 462 under the U.S. Securities Act of 1933, and to
file the same, with all exhibits thereto, and other documents in connection therewith, with the U.S. Securities and Exchange Commission,
granting unto such attorneys-in-fact and agents full power and authority to do and perform each and every act and thing requisite
and necessary to be done in and about the premises, as fully to all intents and purposes as he or she might or could do in person,
hereby ratifying and confirming all that said attorneys-in-fact and agents or either of them or their substitute or substitutes,
may lawfully do or cause to be done by virtue hereof.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">Pursuant to the requirements of the Securities
Act of 1933, as amended, this Registration Statement has been signed by the following persons in the capacities and on the dates
indicated:</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in"></P>

</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
<TR STYLE="vertical-align: top">
    <TD STYLE="width: 33%">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: black 0.5pt solid"><B>Name&nbsp;&nbsp;</B></P></TD>
    <TD STYLE="width: 42%; padding-right: 5pt; padding-left: 5pt">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: black 0.5pt solid"><B>Title&nbsp;&nbsp;&nbsp;</B></P></TD>
    <TD STYLE="width: 25%">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: black 0.5pt solid"><B>Date&nbsp;&nbsp;&nbsp;</B></P></TD></TR>
<TR>
    <TD STYLE="vertical-align: top; text-align: center">&nbsp;</TD>
    <TD STYLE="padding-right: 5pt; padding-left: 5pt">&nbsp;</TD>
    <TD STYLE="text-align: center; text-indent: 30.6pt">&nbsp;</TD></TR>
<TR>
    <TD STYLE="vertical-align: top; text-align: center; border-bottom: Black 1 solid">/s/ Thomas Meyer</TD>
    <TD STYLE="padding-right: 5pt; padding-left: 5pt; text-align: center">Chief Executive Officer and Director</TD>
    <TD STYLE="text-align: center; text-indent: 30.6pt">&nbsp;</TD></TR>
<TR>
    <TD STYLE="vertical-align: middle; text-align: center"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">Thomas Meyer</FONT></TD>
    <TD STYLE="text-align: center; padding-right: 5pt; padding-left: 5pt; vertical-align: middle"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt"></FONT>
<FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">(principal executive officer)</FONT></TD>
    <TD STYLE="text-align: center; text-indent: 30.6pt; vertical-align: middle"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">March 22, 2018</FONT></TD></TR>
<TR>
    <TD STYLE="vertical-align: top; text-align: center">&nbsp;</TD>
    <TD STYLE="text-align: center; padding-right: 5pt; padding-left: 5pt; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; text-indent: 30.6pt; vertical-align: top">&nbsp;</TD></TR>
<TR>
    <TD STYLE="vertical-align: top; text-align: center">&nbsp;</TD>
    <TD STYLE="padding-right: 5pt; padding-left: 5pt; vertical-align: top; text-align: center">&nbsp;</TD>
    <TD STYLE="text-align: center; text-indent: 30.6pt; vertical-align: top">&nbsp;</TD></TR>
<TR>
    <TD STYLE="vertical-align: top; text-align: center; border-bottom: Black 1 solid">/s/ Hernan Levett</TD>
    <TD STYLE="padding-right: 5pt; padding-left: 5pt; vertical-align: top; text-align: center"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">Chief Financial Officer</TD>
    <TD STYLE="text-align: center; text-indent: 30.6pt; vertical-align: top">&nbsp;</TD></TR>
<TR>
    <TD STYLE="vertical-align: top; text-align: center"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">Hernan Levett</FONT></TD>
    <TD STYLE="text-align: center; padding-right: 5pt; padding-left: 5pt; vertical-align: top"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">(principal financial officer and</FONT><BR>
<FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">principal accounting officer)</FONT></TD>
    <TD STYLE="text-align: center; text-indent: 30.6pt; vertical-align: top"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">March 22, 2018</FONT></TD></TR>
<TR>
    <TD STYLE="vertical-align: top; text-align: center">&nbsp;</TD>
    <TD STYLE="text-align: center; padding-right: 5pt; padding-left: 5pt; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; text-indent: 30.6pt; vertical-align: top">&nbsp;</TD></TR>
<TR>
    <TD STYLE="vertical-align: top; text-align: center">&nbsp;</TD>
    <TD STYLE="text-align: center; padding-right: 5pt; padding-left: 5pt; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; text-indent: 30.6pt; vertical-align: top">&nbsp;</TD></TR>
<TR>
    <TD STYLE="vertical-align: top; text-align: center; border-bottom: Black 1 solid">/s/ Armando Anido</TD>
    <TD STYLE="text-align: center; padding-right: 5pt; padding-left: 5pt; vertical-align: top">Director</TD>
    <TD STYLE="text-align: center; text-indent: 30.6pt; vertical-align: top"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">March 22, 2018</TD></TR>
<TR>
    <TD STYLE="vertical-align: top; text-align: center"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">Armando Anido</FONT></TD>
    <TD STYLE="text-align: center; padding-right: 5pt; padding-left: 5pt; vertical-align: top"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt"></FONT></TD>
    <TD STYLE="text-align: center; text-indent: 30.6pt; vertical-align: top"></TD></TR>
<TR>
    <TD STYLE="vertical-align: top; text-align: center">&nbsp;</TD>
    <TD STYLE="text-align: center; padding-right: 5pt; padding-left: 5pt; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; text-indent: 30.6pt; vertical-align: top">&nbsp;</TD></TR>
<TR>
    <TD STYLE="vertical-align: top; text-align: center">&nbsp;</TD>
    <TD STYLE="text-align: center; padding-right: 5pt; padding-left: 5pt; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; text-indent: 30.6pt; vertical-align: top">&nbsp;</TD></TR>
<TR>
    <TD STYLE="vertical-align: top; text-align: center; border-bottom: Black 1 solid">/s/ Mats Blom</TD>
    <TD STYLE="text-align: center; padding-right: 5pt; padding-left: 5pt; vertical-align: top">Director</TD>
    <TD STYLE="text-align: center; text-indent: 30.6pt; vertical-align: top"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">March 22, 2018</TD></TR>
<TR>
    <TD STYLE="vertical-align: top; text-align: center"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">Mats Blom</FONT></TD>
    <TD STYLE="text-align: center; padding-right: 5pt; padding-left: 5pt; vertical-align: top"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt"></FONT></TD>
    <TD STYLE="text-align: center; text-indent: 30.6pt; vertical-align: top"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt"></FONT></TD></TR>
<TR>
    <TD STYLE="vertical-align: top; text-align: center">&nbsp;</TD>
    <TD STYLE="text-align: center; padding-right: 5pt; padding-left: 5pt; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; text-indent: 30.6pt; vertical-align: top">&nbsp;</TD></TR>
<TR>
    <TD STYLE="vertical-align: top; text-align: center">&nbsp;</TD>
    <TD STYLE="text-align: center; padding-right: 5pt; padding-left: 5pt; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; text-indent: 30.6pt; vertical-align: top">&nbsp;</TD></TR>
<TR>
    <TD STYLE="vertical-align: top; text-align: center; border-bottom: Black 1 solid">&nbsp;</TD>
    <TD STYLE="text-align: center; padding-right: 5pt; padding-left: 5pt; vertical-align: top">Director</TD>
    <TD STYLE="text-align: center; text-indent: 30.6pt; vertical-align: top">March
    22, 2018&nbsp;</TD></TR>
<TR>
    <TD STYLE="vertical-align: top; text-align: center"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">Alain Munoz</FONT></TD>
    <TD STYLE="text-align: center; padding-right: 5pt; padding-left: 5pt; vertical-align: top"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt"></FONT></TD>
    <TD STYLE="text-align: center; text-indent: 30.6pt; vertical-align: top"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">&nbsp;</FONT></TD></TR>
<TR>
    <TD STYLE="vertical-align: top; text-align: center">&nbsp;</TD>
    <TD STYLE="text-align: center; padding-right: 5pt; padding-left: 5pt; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; text-indent: 30.6pt; vertical-align: top">&nbsp;</TD></TR>
<TR>
    <TD STYLE="vertical-align: top; text-align: center">&nbsp;</TD>
    <TD STYLE="text-align: center; padding-right: 5pt; padding-left: 5pt; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; text-indent: 30.6pt; vertical-align: top"></TD></TR>
<TR>
    <TD STYLE="vertical-align: top; text-align: center; border-bottom: Black 1 solid">&nbsp;</TD>
    <TD STYLE="text-align: center; padding-right: 5pt; padding-left: 5pt; vertical-align: top">Director</TD>
    <TD STYLE="text-align: center; text-indent: 30.6pt; vertical-align: top"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">March
    22, 2018&nbsp;</FONT></TD></TR>
<TR>
    <TD STYLE="vertical-align: top; text-align: center"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">Calvin W. Roberts</FONT></TD>
    <TD STYLE="text-align: center; padding-right: 5pt; padding-left: 5pt; vertical-align: top"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt"></FONT></TD>
    <TD STYLE="vertical-align: top; text-align: center">&nbsp;</TD></TR>
<TR>
    <TD STYLE="vertical-align: top; text-align: center">&nbsp;</TD>
    <TD STYLE="text-align: center; padding-right: 5pt; padding-left: 5pt; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; text-indent: 30.6pt; vertical-align: top">&nbsp;</TD></TR>
<TR>
    <TD STYLE="vertical-align: top; text-align: center">&nbsp;</TD>
    <TD STYLE="padding-right: 5pt; padding-left: 5pt; vertical-align: top; text-align: center">&nbsp;</TD>
    <TD STYLE="text-align: center; text-indent: 30.6pt; vertical-align: top">&nbsp;</TD></TR>
<TR>
    <TD STYLE="vertical-align: top; text-align: center; border-bottom: Black 1 solid">/s/ Colleen A. DeVries</TD>
    <TD STYLE="padding-right: 5pt; padding-left: 5pt; vertical-align: top; text-align: center">SVP of Cogency Global, Inc.</TD>
    <TD STYLE="text-align: center; text-indent: 30.6pt; vertical-align: top"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">March 22, 2018</TD></TR>
<TR>
    <TD STYLE="vertical-align: top; text-align: center"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">Colleen A. DeVries</FONT></TD>
    <TD STYLE="text-align: center; padding-right: 5pt; padding-left: 5pt; vertical-align: top">
<FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">Authorized Representative in the</FONT><BR>
<FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">United States</FONT></TD>
    <TD STYLE="text-align: center; text-indent: 30.6pt; vertical-align: top"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt"></FONT></TD></TR>
</TABLE>


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<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">EXHIBIT INDEX</P>

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<TR STYLE="vertical-align: bottom">
    <TD STYLE="width: 9%; border-bottom: Black 1pt solid; text-align: center; font-weight: bold">Exhibit Number</TD>
    <TD STYLE="width: 91%; text-align: center; font-weight: bold; padding-left: 3pt">&nbsp;</TD></TR>
<TR>
    <TD STYLE="vertical-align: top; text-align: center; padding-top: 4pt; padding-bottom: 4pt">4.1</TD>
    <TD STYLE="vertical-align: bottom; padding-top: 4pt; padding-bottom: 4pt; padding-left: 3pt">Articles of Association of Auris Medical Holding AG (incorporated by reference to exhibit 1.1 of the Registration Statement on Form 20-F filed with the Commission on March 22, 2018)</TD></TR>
<TR>
    <TD STYLE="vertical-align: top; text-align: center; padding-top: 4pt; padding-bottom: 4pt">4.2</TD>
    <TD STYLE="vertical-align: bottom; padding-top: 4pt; padding-bottom: 4pt; padding-left: 3pt">Form of Registration Rights Agreement (incorporated herein by reference to Exhibit 4.1 to the Registrant&rsquo;s Registration Statement on Form F-1/A, filed with the Commission on July 21, 2014 (Registration File No. 333-197105))</TD></TR>
<TR>
    <TD STYLE="vertical-align: top; text-align: center; padding-top: 4pt; padding-bottom: 4pt">5</TD>
    <TD STYLE="vertical-align: bottom; padding-top: 4pt; padding-bottom: 4pt; padding-left: 3pt">Opinion of Walder Wyss Ltd., Swiss counsel to the Registrant (filed herewith)</TD></TR>
<TR>
    <TD STYLE="vertical-align: top; text-align: center; padding-top: 4pt; padding-bottom: 4pt">23.1</TD>
    <TD STYLE="vertical-align: bottom; padding-top: 4pt; padding-bottom: 4pt; padding-left: 3pt">Consent of Deloitte AG (filed herewith)</TD></TR>
<TR>
    <TD STYLE="vertical-align: top; text-align: center; padding-top: 4pt; padding-bottom: 4pt">23.2</TD>
    <TD STYLE="vertical-align: bottom; padding-top: 4pt; padding-bottom: 4pt; padding-left: 3pt">Consent of Walder Wyss Ltd., Swiss counsel to the Registrant (included in Exhibit 5) </TD></TR>
<TR>
    <TD STYLE="vertical-align: top; text-align: center; padding-top: 4pt; padding-bottom: 4pt">24</TD>
    <TD STYLE="vertical-align: bottom; padding-top: 4pt; padding-bottom: 4pt; padding-left: 3pt">Power of Attorney (included in the signature pages hereof)</TD></TR>
<TR>
    <TD STYLE="vertical-align: top; text-align: center; padding-top: 4pt; padding-bottom: 4pt">99.1</TD>
    <TD STYLE="vertical-align: bottom; padding-top: 4pt; padding-bottom: 4pt; padding-left: 3pt">Auris Medical Holding AG Equity Incentive Plan, as amended (filed herewith)</TD></TR>
<TR>
    <TD STYLE="vertical-align: top; text-align: center; padding-top: 4pt; padding-bottom: 4pt">99.2</TD>
    <TD STYLE="vertical-align: bottom; padding-top: 4pt; padding-bottom: 4pt; padding-left: 3pt">Auris Medical Holding AG Stock Option Plan A, as amended (filed herewith)</TD></TR>
<TR>
    <TD STYLE="vertical-align: top; text-align: center; padding-top: 4pt; padding-bottom: 4pt">99.3</TD>
    <TD STYLE="vertical-align: bottom; padding-top: 4pt; padding-bottom: 4pt; padding-left: 3pt">Amendment to Auris Medical Holding AG Stock Option Plan A (filed herewith)</TD></TR>
<TR>
    <TD STYLE="vertical-align: top; text-align: center; padding-top: 4pt; padding-bottom: 4pt">99.4 </TD>
    <TD STYLE="vertical-align: bottom; padding-top: 4pt; padding-bottom: 4pt; padding-left: 3pt">Auris Medical Holdings AG Stock Option Plan C (filed herewith)</TD></TR></TABLE>




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[{"type": "S-8", "sequence": "1", "filename": "dp88274_s8.htm", "description": "FORM S-8", "secsgml_size_bytes": 63363}]
{"company-data": {"conformed-name": "Auris Medical Holding AG", "cik": "0001601936", "assigned-sic": "2834", "irs-number": "000000000", "state-of-incorporation": "V8", "fiscal-year-end": "1231"}, "filing-values": {"form-type": "S-8", "act": "33", "file-number": "333-223855", "film-number": "18707425"}, "business-address": {"street1": "BAHNHOFSTRASSE 21", "city": "6300 ZUG", "state": "V8", "zip": "00000", "phone": "41 (0)61 201 13 50"}, "mail-address": {"street1": "BAHNHOFSTRASSE 21", "city": "6300 ZUG", "state": "V8", "zip": "00000"}, "former-company": [{"former-conformed-name": "Old Auris Medical Holding AG", "date-changed": "20180314"}, {"former-conformed-name": "Auris Medical Holding AG", "date-changed": "20140529"}, {"former-conformed-name": "Auris Medical AG", "date-changed": "20140306"}]}
As filed with the Securities and Exchange
Commission on March 22, 2018
Registration
No. 333-______
UNITED STATES
SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
____________________
FORM S-8
REGISTRATION STATEMENT
UNDER THE SECURITIES ACT OF 1933
____________________
Auris Medical Holding AG
(Exact Name of Registrant as Specified in
Its Charter)
Switzerland
Not Applicable
(State or Other Jurisdiction of
Incorporation or Organization)
(I.R.S. Employer
Identification Number)
Bahnhofstrasse 21
6300 Zug
Switzerland
(Address,
Including Zip Code of Principal Executive Offices)
____________________
Auris Medical Holding AG Equity Incentive
        Plan, as amended
Auris Medical Holding AG Stock Option
        Plan A
Auris Medical Holding AG Stock Option
        Plan C
(Full title of Plans)
____________________
Cogency Global, Inc.
10 East 40
th
Street, 10th
        Floor
New York, New York 10016
(212) 947-7200
(Name, address and telephone number, including area code, of agent for service)
____________________
Copies to:
Sophia Hudson
Davis Polk & Wardwell LLP
450 Lexington Avenue
New York, New York 10017
(212) 450-4000
Indicate by check mark whether the registrant
is a large accelerated filer, an accelerated filer, a non-accelerated filer, or a smaller reporting company. See the definitions
of "large accelerated filer," "accelerated filer" and "smaller reporting company" in Rule 12b-2
of the Exchange Act.
Large accelerated filer
☐
Accelerated filer
☐
Non-accelerated filer
☒
(Do not check if a smaller reporting company)
Smaller reporting company
☐
____________________
CALCULATION OF REGISTRATION FEE
Title Of Securities To Be Registered
Amount To Be Registered(1)
Proposed Maximum Offering Price Per Share
Proposed Maximum Aggregate Offering Price
Amount Of
Registration Fee
Common Shares, nominal value CHF 0.02 per share, reserved for issuance pursuant to stock option awards outstanding under the EIP, Plan A and Plan C
220,154
$16.70(2)
$3,676,571.80(2)
$457.73(2)
Common Shares, nominal value CHF 0.02 per share, reserved for issuance pursuant to the EIP, Plan A and Plan C
694,846
$1.48(3)
$1,028,372.08(3)
$128.03(3)
Total Common Shares
915,000
N/A
$4,704,943.88
$585.77
(1)
This Registration Statement on Form S-8 (this "Registration Statement") covers (i) common shares, nominal value
CHF 0.02 per share ("Common Shares"), of Auris Medical Holding AG (the "Registrant") issuable pursuant
to (x) the Auris Medical Holding AG Equity Incentive Plan, as amended (the "EIP") assumed by the Registrant in connection
with the Merger (as defined in the Explanatory Statement below) and registered by Old Auris Medical Holding AG (as defined in the
Explanatory Statement below) prior to the Merger on two Registration Statements on Form S-8 (File Nos. 333-200805 and 333-217306)
filed with the U.S. Securities and Exchange Commission (the "Commission") on December 8, 2014 and April 14, 2017, and
(y) the Auris Medical Holding AG Stock Option Plan A, as amended ("Plan A") and Auris Medical Holding AG Stock Option
Plan C ("Plan C") (Plan A and Plan C, and together with the EIP, the "Plans") assumed by the Registrant
in connection with the Merger and registered by Old Auris Medical Holding AG prior to the Merger on one Registration Statement
on Form S-8 (File No. 333-198037), filed with the Commission on August 11, 2014; and (ii) pursuant to Rule 416(a) under the Securities
Act of 1933, as amended (the "Securities Act"), any additional Common Shares that become issuable under the Plans by
reason of any share dividend, share split or other similar transaction.
(2)
Estimated pursuant to Rule 457(h) and Rule 457(c) under the Securities Act, solely for the purpose of computing the registration
fee, based on the weighted average exercise price of the stock options outstanding under the applicable Plan.
(3)
Estimated pursuant to Rule 457(h) and Rule 457(c) under the Securities Act, solely for the purpose of computing the registration
fee for Common Shares to be issued pursuant to the Plans, based on the average of the high and low prices reported for a Common
Share on the NASDAQ Capital Market on March 16, 2018.
EXPLANATORY NOTE
On March 13, 2018, old Auris Medical Holding
AG ("Old Auris Medical Holding AG") merged (the "Merger") into Auris Medical NewCo Holding AG, a newly
incorporated, wholly-owned Swiss subsidiary ("Auris NewCo") following shareholder approval at an extraordinary general
meeting of shareholders held on the same day. Following the Merger, Auris NewCo, the surviving company had a share capital of CHF 122,347.76,
divided into 6,117,388 common shares with a nominal value of CHF 0.02 each. Pursuant to the Merger, the shareholders of Old Auris
Medical Holding AG received one common share with a nominal value of CHF 0.02 of Auris NewCo for every 10 of Old Auris Medical
Holding AG common shares held prior to the Merger, effectively resulting in a "reverse share split" at a ratio of 10-for-1.
Auris NewCo changed its name to Auris Medical Holding AG in connection with the closing of the Merger and as a result, future filings
with the Commission are being made under the name Auris Medical Holding AG, which is the Registrant. On March 14, 2018 the common
shares of Auris NewCo began trading on the Nasdaq Capital Market under the trading symbol "EARS".
PART I
INFORMATION REQUIRED IN THE SECTION
10(a) PROSPECTUS
The documents containing the information
specified in Item 1 and Item 2 of Part I of Form S-8 will be delivered to participants as specified by Rule 428(b)(1) under the
Securities Act. In accordance with the rules and regulations of the Commission and the instructions to Form S-8, such documents
are not being filed with the Commission either as part of this Registration Statement or as prospectuses or prospectus supplements
pursuant to Rule 424 under the Securities Act.
PART II
INFORMATION REQUIRED IN THE REGISTRATION
STATEMENT
Item 3. Incorporation of Documents by Reference.
The following documents are incorporated
herein by reference:
(a)  The
Registrant's Annual Report on Form 20-F for the fiscal year ended December 31, 2017, filed with the Commission on March 22,
2018.
(b)  All
reports filed pursuant to Section 13(a) or 15(d) of the Securities Exchange Act of 1934, as amended (the "Exchange Act"),
since December 31, 2017.
(c)  The description of the Registrant's
Common Shares which is contained in the predecessor to the Registrant's Exchange Act Registration Statement on Form 8-A, dated July 29, 2014 and amended on June 1, 2016, including any amendments or supplements thereto or report
filed for the purpose of updating such description.
In addition, all documents subsequently
filed by the Registrant with the Commission pursuant to Sections 13(a), 13(c), 14 and 15(d) of the Exchange Act, prior to the filing
of a post-effective amendment to this Registration Statement which indicates that all securities offered have been sold or which
deregisters all securities then remaining unsold, shall be deemed to be incorporated by reference in this Registration Statement
and to be a part hereof from the date of the filing of such documents.
Any statement contained in a document incorporated
or deemed to be incorporated by reference herein shall be deemed to be modified or superseded for purposes of this Registration
Statement to the extent that a statement contained herein (or in any other subsequently filed document which also is incorporated
or deemed to be incorporated by reference herein) modifies or supersedes such statement. Any such statement so modified or superseded
shall not be deemed, except as so modified or superseded, to constitute a part of this Registration Statement.
Item 4. Description of Securities.
Not applicable.
Item 5. Interests of Named Experts and Counsel.
Not applicable.
Item 6. Indemnification of Directors and Officers.
Under Swiss law, a corporation may indemnify
its directors or officers against losses and expenses (except for such losses and expenses arising from willful misconduct or negligence,
although legal scholars advocate that at least gross negligence be required), including attorney's fees, judgments, fines
and settlement amounts actually and reasonably incurred in a civil or criminal action, suit or proceeding by reason of having been
the representative of, or serving at the request of, the corporation.
Subject to Swiss law, Article 17 of the
Registrant's articles of association provides for indemnification of the existing and former members of our board of directors,
executive management, and their heirs, executors and administrators, against liabilities arising in connection with the performance
of their duties in such capacity, and permits the Registrant to advance the expenses of defending any act, suit or proceeding to
members of the Registrant's board of directors and executive management.
In addition, under general principles of
Swiss employment law, an employer may be required to indemnify an employee against losses and expenses incurred by such employee
in the proper execution of their duties under the employment agreement with the company.
The Registrant has entered into indemnification
agreements with each of the members of our board of directors and executive officers in the form filed as Exhibit 99.4 to the Registrant's
Form 6-K filed with the Commission on May 11, 2016.
Insofar as indemnification for liabilities
arising under the Securities Act of 1933, as amended, may be permitted to directors, officers and controlling persons of the Registrant,
the Registrant has been advised that, in the opinion of the Securities and Exchange Commission, such indemnification is against
public policy as expressed in the Securities Act of 1933, as amended, and is, therefore, unenforceable.
Item 7. Exemption from Registration Claimed
Not Applicable.
Item 8. Exhibits.
Exhibit Number
4.1
Articles of Association of Auris Medical Holding AG (incorporated by reference to exhibit 1.1 of the Registration Statement on Form 20-F filed with the Commission on March 22, 2018)
4.2
Form of Registration Rights Agreement (incorporated herein by reference to Exhibit 4.1 to the Registrant's Registration Statement on Form F-1/A, filed with the Commission on July 21, 2014 (Registration File No. 333-197105))
5
Opinion of Walder Wyss Ltd., Swiss counsel to the Registrant (filed herewith)
23.1
Consent of Deloitte AG (filed herewith)
23.2
Consent of Walder Wyss Ltd., Swiss counsel to the Registrant (included in Exhibit 5)
24
Power of Attorney (included in the signature pages hereof)
99.1
Auris Medical Holding AG Equity Incentive Plan, as amended (filed herewith)
99.2
Auris Medical Holding AG Stock Option Plan A, as amended (filed herewith)
99.3
Amendment to Auris Medical Holding AG Stock Option Plan A (filed herewith)
99.4
Auris Medical Holdings AG Stock Option Plan C (filed herewith)
2
Item 9. Undertakings.
(a)  The undersigned Registrant
hereby undertakes:
(1)  To file, during any period
in which offers or sales are being made, a post-effective amendment to this Registration Statement:
(i)  To include any
prospectus required by Section 10(a)(3) of the Securities Act;
(ii)  To reflect in the
prospectus any facts or events arising after the effective date of this Registration Statement (or the most recent post-effective
amendment thereof) which, individually or in the aggregate, represent a fundamental change in the information set forth in this
Registration Statement. Notwithstanding the foregoing, any increase or decrease in volume of securities offered (if the total dollar
value of securities offered would not exceed that which was registered) and any deviation from the low or high end of the estimated
maximum offering range may be reflected in the form of prospectus filed with the Commission pursuant to Rule 424(b) if, in the
aggregate, the changes in volume and price represent no more than a 20 percent change in the maximum aggregate offering price set
forth in the "Calculation of Registration Fee" table in the effective Registration Statement;
(iii)  To include
any material information with respect to the Plans not previously disclosed in this Registration Statement or any material change
to such information in this Registration Statement;
provided
,
however
, that paragraphs (a)(1)(i)
and (a)(1)(ii) do not apply if the information required to be included in a post-effective amendment by those paragraphs is contained
in periodic reports filed with or furnished to the Commission by the Registrant pursuant to Section 13 or 15(d) of the Exchange
Act that are incorporated by reference in this Registration Statement.
(2)  That, for the purpose of
determining any liability under the Securities Act, each such post-effective amendment shall be deemed to be a new registration
statement relating to the securities offered therein, and the offering of such securities at that time shall be deemed to be the
initial
bona fide
offering thereof.
(3)  To remove from registration
by means of a post-effective amendment any of the securities being registered which remain unsold at the termination of the offering.
(4) To file a post-effective amendment
to the registration statement to include any financial statements required by Item 8.A. of Form 20-F at the start of any delayed
offering or throughout a continuous offering. Financial statements and information otherwise required by Section 10(a)(3) of the
Act need not be furnished, provided that the registrant includes in the prospectus, by means of a post-effective amendment, financial
statements required pursuant to this paragraph (a)(4) and other information necessary to ensure that all other information in the
prospectus is at least as current as the date of those financial statements. Notwithstanding the foregoing, with respect to registration
statements on Form F-3, a post-effective amendment need not be filed to include financial statements and information required by
Section 10(a)(3) of the Act or Rule 3-19 of this chapter if such financial statements and information are contained in periodic
reports filed with or furnished to the Commission by the registrant pursuant to section 13 or section 15(d) of the Securities Exchange
Act of 1934 that are incorporated by reference in the Form F-3.
(b)  The undersigned Registrant
hereby undertakes that, for purposes of determining any liability under the Securities Act, each filing of the Registrant's
annual report pursuant to Section 13(a) or 15(d) of the Exchange Act (and, where applicable, each filing of an employee benefit
plan's annual report pursuant to Section 15(d) of the Exchange Act) that is incorporated by reference in this Registration
Statement shall be deemed to be a new registration statement relating to the securities offered therein, and the offering of such
securities at that time shall be deemed to be the initial
bona fide
offering thereof.
3
(c)  Insofar as indemnification
for liabilities arising under the Securities Act may be permitted to directors, officers and controlling persons of the Registrant
pursuant to the foregoing provisions, or otherwise, the Registrant has been advised that in the opinion of the Commission such
indemnification is against public policy as expressed in the Securities Act and is, therefore, unenforceable.  In the
event that a claim for indemnification against such liabilities (other than the payment by the Registrant of expenses incurred
or paid by a director, officer or controlling person of the Registrant in the successful defense of any action, suit or proceeding)
is asserted by such director, officer or controlling person in connection with the securities being registered, the Registrant
will, unless in the opinion of its counsel the matter has been settled by controlling precedent, submit to a court of appropriate
jurisdiction the question whether such indemnification by it is against public policy as expressed in the Securities Act and will
be governed by the final adjudication of such issue.
4
Signatures
Pursuant to the requirements of the Securities
Act of 1933, the Registrant certifies that it has reasonable grounds to believe that it meets all of the requirements for filing
this Registration Statement and has duly caused this Registration Statement to be signed on its behalf by the undersigned, thereunto
duly authorized, in Zug, Switzerland on this 22nd day of March, 2018.
Auris Medical Holding AG
By:
/s/ Thomas Meyer
Name:	Thomas Meyer
Title:	  Chief Executive Officer
5
POWER OF ATTORNEY
KNOW ALL PERSONS BY THESE PRESENTS, that
each person whose signature appears below hereby constitutes and appoints Thomas Meyer, Hernan Levett and Raoul Dias and each of
them, individually, as his or her true and lawful attorneys-in-fact and agents, with full power of substitution and resubstitution,
for him or her and in his or her name, place and stead in any and all capacities, in connection with this Registration Statement,
including to sign in the name and on behalf of the undersigned, this Registration Statement and any and all amendments thereto,
including post-effective amendments and registrations filed pursuant to Rule 462 under the U.S. Securities Act of 1933, and to
file the same, with all exhibits thereto, and other documents in connection therewith, with the U.S. Securities and Exchange Commission,
granting unto such attorneys-in-fact and agents full power and authority to do and perform each and every act and thing requisite
and necessary to be done in and about the premises, as fully to all intents and purposes as he or she might or could do in person,
hereby ratifying and confirming all that said attorneys-in-fact and agents or either of them or their substitute or substitutes,
may lawfully do or cause to be done by virtue hereof.
Pursuant to the requirements of the Securities
Act of 1933, as amended, this Registration Statement has been signed by the following persons in the capacities and on the dates
indicated:
Name
Title
Date
/s/ Thomas Meyer
Chief Executive Officer and Director
Thomas Meyer
(principal executive officer)
March 22, 2018
/s/ Hernan Levett
Chief Financial Officer
Hernan Levett
(principal financial officer and
principal accounting officer)
March 22, 2018
/s/ Armando Anido
Director
March 22, 2018
Armando Anido
/s/ Mats Blom
Director
March 22, 2018
Mats Blom
Director
March
    22, 2018
Alain Munoz
Director
March
    22, 2018
Calvin W. Roberts
/s/ Colleen A. DeVries
SVP of Cogency Global, Inc.
March 22, 2018
Colleen A. DeVries
Authorized Representative in the
United States
6
EXHIBIT INDEX
Exhibit Number
4.1
Articles of Association of Auris Medical Holding AG (incorporated by reference to exhibit 1.1 of the Registration Statement on Form 20-F filed with the Commission on March 22, 2018)
4.2
Form of Registration Rights Agreement (incorporated herein by reference to Exhibit 4.1 to the Registrant's Registration Statement on Form F-1/A, filed with the Commission on July 21, 2014 (Registration File No. 333-197105))
5
Opinion of Walder Wyss Ltd., Swiss counsel to the Registrant (filed herewith)
23.1
Consent of Deloitte AG (filed herewith)
23.2
Consent of Walder Wyss Ltd., Swiss counsel to the Registrant (included in Exhibit 5)
24
Power of Attorney (included in the signature pages hereof)
99.1
Auris Medical Holding AG Equity Incentive Plan, as amended (filed herewith)
99.2
Auris Medical Holding AG Stock Option Plan A, as amended (filed herewith)
99.3
Amendment to Auris Medical Holding AG Stock Option Plan A (filed herewith)
99.4
Auris Medical Holdings AG Stock Option Plan C (filed herewith)
7