<HTML>
<HEAD>
<TITLE>La Jolla Pharmaceutical Company</TITLE>
</HEAD>
<BODY bgcolor="#FFFFFF">
<!-- PAGEBREAK -->
<H5 align="left" style="page-break-before:always"><A HREF="#toc">Table of Contents</A></H5><P>


<P align="center"><FONT size="2">As filed with the Securities and
Exchange Commission on June 12, 2003. Registration No.&nbsp;333-_____________
</FONT>

<HR size="4" noshade color="#000000" style="margin-top: -5px">
<HR size="1" noshade color="#000000" style="margin-top: -10px">





<P align="center"><FONT size="4">UNITED STATES</FONT>


<DIV align="center"><FONT size="4">SECURITIES AND EXCHANGE COMMISSION
</FONT></DIV>


<DIV align="center"><FONT size="3">WASHINGTON, DC 20549
</FONT></DIV>


<DIV align="center"><HR align="center" size="1" width="20%" noshade></DIV>


<P align="center"><FONT size="5"><B>FORM S-8
</B></FONT>


<P align="center"><FONT size="2"><B>REGISTRATION STATEMENT</B>
</FONT>


<DIV align="center"><FONT size="2"><B>UNDER</B>
</FONT></DIV>


<DIV align="center"><FONT size="2"><B>THE SECURITIES ACT OF 1933</B>
</FONT></DIV>


<P align="center"><FONT size="6"><B>LA JOLLA PHARMACEUTICAL COMPANY
</B></FONT>


<DIV align="center"><FONT size="2">(Exact Name of Registrant as Specified in Its Charter)
</FONT></DIV>

<CENTER>
<TABLE cellspacing="0" border="0" cellpadding="0" width="65%">
<TR valign="bottom">
    <TD width="51%">&nbsp;</TD>
    <TD width="5%">&nbsp;</TD>
    <TD width="44%">&nbsp;</TD>
</TR>
<TR valign="bottom">
    <TD align="center" valign="top"><FONT size="2"><B>Delaware</B></FONT></TD>
    <TD><FONT size="2">&nbsp;</FONT></TD>
    <TD align="center" valign="top"><FONT size="2">
<B>33-0361285</B></FONT></TD>
</TR>

<TR valign="bottom">
    <TD align="center" valign="top"><FONT size="2">(State or Other Jurisdiction of<BR>
Incorporation or Organization)</FONT></TD>
    <TD><FONT size="2">&nbsp;</FONT></TD>
    <TD align="center" valign="top"><FONT size="2">
(I.R.S. Employer Identification No.)</FONT></TD>
</TR>
</TABLE>
</CENTER>

<DIV align="center"><HR align="center" size="1" width="20%" noshade></DIV>


<P align="center"><FONT size="2">6455 Nancy Ridge Drive
</FONT>


<DIV align="center"><FONT size="2">San Diego, California 92121
</FONT></DIV>


<DIV align="center"><FONT size="2">(Address, including Zip Code, of Principal Executive Offices)
</FONT></DIV>


<P align="center"><FONT size="2"><B>LA JOLLA PHARMACEUTICAL COMPANY 1994 STOCK INCENTIVE PLAN</B>
</FONT>


<DIV align="center"><FONT size="2">(Full Title of the Plan)
</FONT></DIV>


<DIV align="center"><HR align="center" size="1" width="20%" noshade></DIV>


<P align="center"><FONT size="2">Steven B. Engle
</FONT>


<DIV align="center"><FONT size="2">La Jolla Pharmaceutical Company
</FONT></DIV>


<DIV align="center"><FONT size="2">6455 Nancy Ridge Drive
</FONT></DIV>


<DIV align="center"><FONT size="2">San Diego, California 92121
</FONT></DIV>


<DIV align="center"><FONT size="2">(858)&nbsp;452-6600
</FONT></DIV>


<DIV align="center"><FONT size="2">(Name, address, and telephone number, including area code, of Agent For Service)
</FONT></DIV>


<P align="center"><FONT size="2">Copy to:
</FONT>


<DIV align="center"><FONT size="2">Mark W. Shurtleff, Esq.
</FONT></DIV>


<DIV align="center"><FONT size="2">Gibson, Dunn &#038; Crutcher LLP
</FONT></DIV>


<DIV align="center"><FONT size="2">4 Park Plaza, Suite&nbsp;1700
</FONT></DIV>


<DIV align="center"><FONT size="2">Irvine, California 92614
</FONT></DIV>


<DIV align="center"><FONT size="2">(949)&nbsp;451-3800
</FONT></DIV>


<P>
<HR size="1" noshade color="#000000" style="margin-top: -2px">
<HR size="4" noshade color="#000000" style="margin-top: -10px">




<P align="center"><FONT size="2">&nbsp;</FONT>

<!-- PAGEBREAK -->
<P><HR noshade><P>
<H5 align="left" style="page-break-before:always"><A HREF="#toc">Table of Contents</A></H5><P>







<P align="center"><FONT size="2"><B>CALCULATION OF REGISTRATION FEE</B>
</FONT>

<CENTER>
<TABLE cellspacing="0" border="0" cellpadding="0" width="100%">
<TR valign="bottom">
    <TD width="51%">&nbsp;</TD>
    <TD width="3%">&nbsp;</TD>
    <TD width="7%">&nbsp;</TD>
    <TD width="1%">&nbsp;</TD>
    <TD width="7%">&nbsp;</TD>
    <TD width="3%">&nbsp;</TD>
    <TD width="1%">&nbsp;</TD>
    <TD width="1%">&nbsp;</TD>
    <TD width="2%">&nbsp;</TD>
    <TD width="3%">&nbsp;</TD>
    <TD width="5%">&nbsp;</TD>
    <TD width="1%">&nbsp;</TD>
    <TD width="6%">&nbsp;</TD>
    <TD width="3%">&nbsp;</TD>
    <TD width="2%">&nbsp;</TD>
    <TD width="1%">&nbsp;</TD>
    <TD width="3%">&nbsp;</TD>
</TR>
<TR valign="bottom">
    <TD><FONT size="1">&nbsp;</FONT></TD>
    <TD><FONT size="1">&nbsp;</FONT></TD>
    <TD><FONT size="1">&nbsp;</FONT></TD>
    <TD><FONT size="1">&nbsp;</FONT></TD>
    <TD><FONT size="1">&nbsp;</FONT></TD>
    <TD><FONT size="1">&nbsp;</FONT></TD>
    <TD nowrap align="center" colspan="3"><FONT size="1"><B>PROPOSED</B></FONT></TD>
    <TD><FONT size="1">&nbsp;</FONT></TD>
    <TD nowrap align="center" colspan="3"><FONT size="1"><B>PROPOSED</B></FONT></TD>
    <TD><FONT size="1">&nbsp;</FONT></TD>
    <TD><FONT size="1">&nbsp;</FONT></TD>
    <TD><FONT size="1">&nbsp;</FONT></TD>
    <TD><FONT size="1">&nbsp;</FONT></TD>
</TR>
<TR valign="bottom">
    <TD nowrap align="center"><FONT size="1"><B>TITLE OF</B></FONT></TD>
    <TD><FONT size="1">&nbsp;</FONT></TD>
    <TD><FONT size="1">&nbsp;</FONT></TD>
    <TD><FONT size="1">&nbsp;</FONT></TD>
    <TD><FONT size="1">&nbsp;</FONT></TD>
    <TD><FONT size="1">&nbsp;</FONT></TD>
    <TD nowrap align="center" colspan="3"><FONT size="1"><B>MAXIMUM</B></FONT></TD>
    <TD><FONT size="1">&nbsp;</FONT></TD>
    <TD nowrap align="center" colspan="3"><FONT size="1"><B>MAXIMUM</B></FONT></TD>
    <TD><FONT size="1">&nbsp;</FONT></TD>
    <TD><FONT size="1">&nbsp;</FONT></TD>
    <TD><FONT size="1">&nbsp;</FONT></TD>
    <TD><FONT size="1">&nbsp;</FONT></TD>
</TR>
<TR valign="bottom">
    <TD nowrap align="center"><FONT size="1"><B>SECURITIES</B></FONT></TD>
    <TD><FONT size="1">&nbsp;</FONT></TD>
    <TD nowrap align="center" colspan="3"><FONT size="1"><B>AMOUNT TO BE</B></FONT></TD>
    <TD><FONT size="1">&nbsp;</FONT></TD>
    <TD nowrap align="center" colspan="3"><FONT size="1"><B>OFFERING PRICE</B></FONT></TD>
    <TD><FONT size="1">&nbsp;</FONT></TD>
    <TD nowrap align="center" colspan="3"><FONT size="1"><B>AGGREGATE</B></FONT></TD>
    <TD><FONT size="1">&nbsp;</FONT></TD>
    <TD nowrap align="center" colspan="3"><FONT size="1"><B>AMOUNT OF</B></FONT></TD>
</TR>
<TR valign="bottom">
    <TD nowrap align="center"><FONT size="1"><B>TO BE REGISTERED</B></FONT></TD>
    <TD><FONT size="1">&nbsp;</FONT></TD>
    <TD nowrap align="center" colspan="3"><FONT size="1"><B>REGISTERED(1)</B></FONT></TD>
    <TD><FONT size="1">&nbsp;</FONT></TD>
    <TD nowrap align="center" colspan="3"><FONT size="1"><B>PER SHARE(2)</B></FONT></TD>
    <TD><FONT size="1">&nbsp;</FONT></TD>
    <TD nowrap align="center" colspan="3"><FONT size="1"><B>OFFERING PRICE(2)</B></FONT></TD>
    <TD><FONT size="1">&nbsp;</FONT></TD>
    <TD nowrap align="center" colspan="3"><FONT size="1"><B>REGISTRATION FEE</B></FONT></TD>
</TR>
<TR valign="bottom">
    <TD nowrap align="center"><HR size="1" noshade></TD>
    <TD><FONT size="1">&nbsp;</FONT></TD>
    <TD colspan="3"><HR size="1" noshade></TD>
    <TD><FONT size="1">&nbsp;</FONT></TD>
    <TD colspan="3"><HR size="1" noshade></TD>
    <TD><FONT size="1">&nbsp;</FONT></TD>
    <TD colspan="3"><HR size="1" noshade></TD>
    <TD><FONT size="1">&nbsp;</FONT></TD>
    <TD colspan="3"><HR size="1" noshade></TD>
</TR>
<TR valign="bottom">
    <TD><DIV style="margin-left:10px; text-indent:-10px"><FONT size="2">Common Stock, par value $0.01 per share</FONT></DIV></TD>
    <TD><FONT size="2">&nbsp;</FONT></TD>
    <TD nowrap align="right"><FONT size="2">&nbsp;</FONT></TD>
    <TD align="right"><FONT size="2">1,100,000 </FONT></TD>
    <TD nowrap><FONT size="2">(3)</FONT></TD>
    <TD><FONT size="2">&nbsp;</FONT></TD>
    <TD align="right"><FONT size="2">$</FONT></TD>
    <TD align="right"><FONT size="2">3.76</FONT></TD>
    <TD><FONT size="2">&nbsp;</FONT></TD>
    <TD><FONT size="2">&nbsp;</FONT></TD>
    <TD align="right"><FONT size="2">$</FONT></TD>
    <TD align="right"><FONT size="2">4,136,000</FONT></TD>
    <TD><FONT size="2">&nbsp;</FONT></TD>
    <TD><FONT size="2">&nbsp;</FONT></TD>
    <TD align="right"><FONT size="2">$</FONT></TD>
    <TD align="right"><FONT size="2">335</FONT></TD>
    <TD><FONT size="2">&nbsp;</FONT></TD>
</TR>
</TABLE>
</CENTER>

<P>
<HR size="1" width="18%" align="left" noshade>
<TABLE width="100%" border="0" cellpadding="0" cellspacing="0">
<TR valign="top">
    <TD width="1%" align="left" nowrap><FONT size="2">(1)</FONT></TD>
    <TD width="3%"><FONT size="2">&nbsp;</FONT></TD>
    <TD width="96%"><FONT size="2">Each share of common stock includes a right to purchase one
one-thousandth of a share of Series&nbsp;A Junior Participating Preferred Stock
pursuant to the Rights Agreement between the Registrant and American Stock
Transfer &#038; Trust Company, as Rights Agent, as amended. Pursuant to Rule
416(a), this Registration Statement also covers shares of common stock
which may be issued pursuant to antidilution provisions contained in the
La Jolla Pharmaceutical Company 1994 Stock Incentive Plan.</FONT></TD>
</TR>
<TR>
    <TD><FONT size="2">&nbsp;</FONT></TD>
</TR>
<TR valign="top">
    <TD width="1%" align="left" nowrap><FONT size="2">(2)</FONT></TD>
    <TD width="3%"><FONT size="2">&nbsp;</FONT></TD>
    <TD width="96%"><FONT size="2">Estimated solely for the purpose of calculating the registration fee
pursuant to Rules&nbsp;457(c) and 457(h) and based on the average of the high
and the low price of the common stock of the registrant as reported on
June&nbsp;5, 2003 on the Nasdaq National Market System.</FONT></TD>
</TR>
<TR>
    <TD><FONT size="2">&nbsp;</FONT></TD>
</TR>
<TR valign="top">
    <TD width="1%" align="left" nowrap><FONT size="2">(3)</FONT></TD>
    <TD width="3%"><FONT size="2">&nbsp;</FONT></TD>
    <TD width="96%"><FONT size="2">Represents a 1,100,000 share increase in the number of shares authorized
for issuance under the La Jolla Pharmaceutical Company 1994 Stock
Incentive Plan. 8,200,000 shares of our common stock are issuable under
the 1994 Stock Incentive Plan. In addition to the shares of common stock
registered hereby, 750,000 shares of our common stock issuable under the
1994 Stock Incentive Plan were previously registered under the
Registration Statement on Form&nbsp;S-8 (Registration No.&nbsp;33-82664) as filed
with the Securities and Exchange Commission on August&nbsp;11, 1994; 500,000
shares of our common stock issuable under the 1994 Stock Incentive Plan
were previously registered under the Registration Statement on Form&nbsp;S-8
(Registration No.&nbsp;333-14285) as filed with the Securities and Exchange
Commission on October&nbsp;17, 1996; 500,000 shares of our common stock
issuable under the 1994 Stock Incentive Plan were previously registered
under the Registration Statement on Form&nbsp;S-8 (Registration No.&nbsp;333-29575)
as filed with the Securities and Exchange Commission on June&nbsp;19, 1997;
750,000 shares of our common stock issuable under the 1994 Stock Incentive
Plan were previously registered under the Registration Statement on Form
S-8 (Registration No.&nbsp;333-91593) as filed with the Securities and Exchange
Commission on November&nbsp;24, 1999; 1,000,000 shares of our common stock
issuable under the 1994 Stock Incentive Plan were previously registered
under the Registration Statement on Form&nbsp;S-8 (Registration No.&nbsp;333-45080)
as filed with the Securities and Exchange Commission on September&nbsp;1, 2000;
1,700,000 shares of our common stock issuable under the 1994 Stock
Incentive Plan were previously registered under the Registration Statement
on Form&nbsp;S-8 (Registration No.&nbsp;333-69104) as filed with the Securities and
Exchange Commission on September&nbsp;7, 2001; and 1,900,000 shares of our
common stock issuable under the 1994 Stock Incentive Plan were previously
registered under the Registration Statement on Form&nbsp;S-8 (Registration No.
333-89980) as filed with the Securities and Exchange Commission on June&nbsp;6,
2002.</FONT></TD>
</TR>
</TABLE>

<P>
<HR size="1" noshade color="#000000" style="margin-top: -2px">
<HR size="4" noshade color="#000000" style="margin-top: -10px">




<P align="center"><FONT size="2">&nbsp;</FONT>

<!-- PAGEBREAK -->
<P><HR noshade><P>




<!-- TOC -->
<A name="toc"><DIV align="CENTER" style="page-break-before:always"><U><B>TABLE OF CONTENTS</B></U></DIV></A>

<P><CENTER>
<TABLE border="0" width="90%" cellpadding="0" cellspacing="0">
<TR>
	<TD width="3%"></TD>
	<TD width="3%"></TD>
	<TD width="3%"></TD>
	<TD width="3%"></TD>
	<TD width="3%"></TD>
	<TD width="3%"></TD>
	<TD width="3%"></TD>
	<TD width="3%"></TD>
	<TD width="76%"></TD>
</TR>
<TR><TD colspan="9"><A HREF="#000">PART I</A></TD></TR>
<TR><TD colspan="9"><A HREF="#001">PART II</A></TD></TR>
<TR><TD></TD><TD colspan="8"><A HREF="#002">Item&nbsp;6. Indemnification of Officers and Directors</A></TD></TR>
<TR><TD></TD><TD colspan="8"><A HREF="#003">Item&nbsp;8. Exhibits.</A></TD></TR>
<TR><TD colspan="9"><A HREF="#004">SIGNATURES</A></TD></TR>
<TR><TD colspan="9"><A HREF="#005">EXHIBIT INDEX</A></TD></TR>
<TR><TD colspan="9"><A HREF="a90848exv5w1.txt">EXHIBIT 5.1</A></TD></TR>
<TR><TD colspan="9"><A HREF="a90848exv23w1.txt">EXHIBIT 23.1</A></TD></TR>
</TABLE>
</CENTER>
<!-- /TOC -->
<P><HR noshade><P>
<H5 align="left" style="page-break-before:always"><A HREF="#toc">Table of Contents</A></H5><P>





<P align="center"><FONT size="2"><B>INTRODUCTION</B>
</FONT>

<P align="left"><FONT size="2">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;We are filing this Registration Statement on Form&nbsp;S-8 to register an
additional 1,100,000 shares of our common stock that we may issue under the La
Jolla Pharmaceutical Company 1994 Stock Incentive Plan. We have included in
this Registration Statement only those items required by General Instruction E
to Form&nbsp;S-8.
</FONT>

<!-- link1 "PART I" -->
<DIV align="left"><A NAME="000"></A></DIV>

<P align="center"><FONT size="2"><B>PART I</B>
</FONT>


<DIV align="center"><FONT size="2"><B>INFORMATION REQUIRED IN THE SECTION 10(a) PROSPECTUS</B>
</FONT></DIV>

<P align="left"><FONT size="2">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Information required by Part I of Form&nbsp;S-8 to be contained in the Section
10(a) prospectus is omitted from this Registration Statement in accordance with
Rule&nbsp;428 under the Securities Act of 1933, as amended, and the Note to Part I
of Form&nbsp;S-8.
</FONT>

<!-- link1 "PART II" -->
<DIV align="left"><A NAME="001"></A></DIV>

<P align="center"><FONT size="2"><B>PART II</B>
</FONT>


<DIV align="center"><FONT size="2"><B>INFORMATION REQUIRED IN THE REGISTRATION STATEMENT</B>
</FONT></DIV>

<P align="left"><FONT size="2">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;In accordance with General Instruction E to Form&nbsp;S-8, the contents of our
Registration Statement on Form&nbsp;S-8 (Registration No.&nbsp;33-82664) previously filed
by us with the Securities and Exchange Commission on August&nbsp;11, 1994 relating
to the 1994 Stock Incentive Plan is incorporated herein by reference and made a
part hereof. In addition, the contents of our Registration Statement on Form
S-8 (Registration No.&nbsp;333-69104) previously filed by us with the Securities and
Exchange Commission on September&nbsp;7, 2001, which Registration Statement contains
updated information under the heading &#147;Undertakings,&#148; is incorporated herein by
reference and made a part hereof.
</FONT>

<!-- link2 "Item&nbsp;6. Indemnification of Officers and Directors" -->
<DIV align="left"><A NAME="002"></A></DIV>

<P align="left"><FONT size="2"><B>Item&nbsp;6. Indemnification of Officers and Directors</B>
</FONT>

<P align="left"><FONT size="2">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Section&nbsp;145(a) of the General Corporation Law of the State of Delaware
(the &#147;DGCL&#148;) provides that a Delaware corporation may indemnify any person who
was or is a party or is threatened to be made a party to any threatened,
pending or completed action, suit or proceeding, whether civil, criminal,
administrative or investigative, other than an action by or in the right of the
corporation, by reason of the fact that such person is or was a director,
officer, employee or agent of the corporation or is or was serving at the
request of the corporation as a director, officer, employee or agent of another
corporation or enterprise, against expenses, judgments, fines and amounts paid
in settlement actually and reasonably incurred by such person in connection
with such action, suit or proceeding if he or she acted in good faith and in a
manner he or she reasonably believed to be in or not opposed to the best
interests of the corporation, and, with respect to any criminal action or
proceeding, had no cause to believe his or her conduct was unlawful.
</FONT>

<P align="left"><FONT size="2">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Section&nbsp;145(b) of the DGCL provides that a Delaware corporation may
indemnify any person who was or is a party or is threatened to be made a party
to any threatened, pending or completed action or suit by or in the right of
the corporation to procure a judgment in its favor by reason of the fact that
such person acted in any of the capacities set forth above, against expenses
actually and reasonably incurred by such person in connection with the defense
or settlement of such action or suit if he or she acted under similar standards
to those set forth above, except that no indemnification may be made in respect
to any claim, issue or matter as to which such person shall have been adjudged
to be liable to the corporation unless and only to the extent that the court in
which such action or suit was brought shall determine that despite the
adjudication of liability, but in view of all the circumstances of the case,
such person is fairly and reasonably entitled to be indemnified for such
expenses which the court shall deem proper.
</FONT>

<P align="left"><FONT size="2">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Section&nbsp;145 of the DGCL further provides that to the extent a director or
officer of a corporation has been successful in the defense of any action, suit
or proceeding referred to in subsection (a)&nbsp;and (b)&nbsp;of Section&nbsp;145 or in the
defense of any claim, issue or matter therein, he or she shall be indemnified
against expenses actually and reasonably incurred by him or her in connection
therewith; that indemnification provided for by Section&nbsp;145 shall not be deemed
exclusive of any other rights to which the indemnified party may be entitled;
and that the corporation may purchase and maintain insurance on behalf of a
director or officer of the corporation against any liability asserted against
such officer or director and incurred by him or her in any such capacity or
arising out of his or her
<P align="center"><FONT size="2">&nbsp;</FONT>

<!-- PAGEBREAK -->
<P><HR noshade><P>
<H5 align="left" style="page-break-before:always"><A HREF="#toc">Table of Contents</A></H5><P>

<P align="left"><FONT size="2">status as such, whether or not the corporation would have the power to
indemnify him or her against such liabilities under Section&nbsp;145.
</FONT>

<P align="left"><FONT size="2">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;As permitted by Section&nbsp;102(b)(7) of the DGCL our certificate of
incorporation provides that a director shall not be liable to us or our
stockholders for monetary damages for breach of fiduciary duty as a director.
However, such provision does not eliminate or limit the liability of a director
for acts or omissions not in good faith or for breaching his or her duty of
loyalty, engaging in intentional misconduct, knowingly violating the law,
paying an illegal dividend, approving an illegal stock repurchase, or obtaining
an improper personal benefit. A provision of this type has no effect on the
availability of equitable remedies, such as injunction or rescission, for
breach of fiduciary duty.
</FONT>

<P align="left"><FONT size="2">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Our bylaws require that directors and officers be indemnified to the
maximum extent permitted by Delaware law.
</FONT>

<P align="left"><FONT size="2">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;We have entered into indemnity agreements with each of our directors and
executive officers. These indemnity agreements generally require that we pay
on behalf of each director and officer party thereto all amounts that he or she
is or becomes legally obligated to pay because of any claim or claims made
against him or her because of any act or omission or which he or she commits or
suffers while acting in his or her capacity as our director and/or officer and
because of his or her being a director and/or officer. Under the DGCL, absent
an indemnity agreement or a provision in a corporation&#146;s bylaws or certificate
of incorporation, indemnification of a director or officer is discretionary
rather than mandatory (except in the case of a proceeding in which a director
or officer is successful on the merits). In addition, if indemnification is
unavailable and may not be paid to an officer or director, we have agreed,
subject to a limited number of exceptions, to contribute to the amount of
expenses incurred or payable by the officer or director, to the extent allowed
by applicable law, in such proportion as is appropriate to reflect the relative
benefits received by us, on the one hand, and by the officer or director, on
the other, from the transaction from which the proceeding arose and the
relative faults of the parties, as well as any other applicable equitable
considerations.
</FONT>

<P align="left"><FONT size="2">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Consistent with our bylaw provision on the subject, the indemnity
agreements require us to make prompt payment of defense and investigation costs
and expenses at the request of the director or officer in advance of
indemnification, provided that the recipient undertakes to repay the amounts if
it is ultimately determined that he or she is not entitled to indemnification
for such expenses and provided further that such advance shall not be made if
it is determined that the director or officer would not be permitted to be
indemnified under applicable law. The indemnity agreements make the advance of
litigation expenses mandatory absent a special determination to the contrary.
Under the DGCL, absent an indemnity agreement or a provision in a corporation&#146;s
bylaws or certificate of incorporation, the advancement of expenses is
discretionary. Under the indemnity agreement, the director or officer is
permitted to petition the court to seek recovery of amounts due under the
indemnity agreement and to recover the expenses of seeking such recovery if he
or she is successful. The benefits of the indemnity agreement will not be
available to the extent that an officer or director has other indemnification
or insurance coverage for the subject claim. In addition, no indemnity will be
paid by us: with respect to remuneration paid to an officer or director if it
is determined by a final judgment that such remuneration was in violation of
law; on account of any suit or judgment rendered against an officer or director
for violating Section&nbsp;16(b) of the Securities Exchange Act of 1934, or
analogous provisions of law; if an officer&#146;s or director&#146;s conduct
is adjudged to be fraudulent or deliberately dishonest, or constitutes willful misconduct; or (iv)&nbsp;if it is adjudged that indemnification
is not lawful. Absent the indemnity agreement, indemnification that might be
made available to directors and officers could be changed by amendments to our
certificate of incorporation or bylaws.
</FONT>

<P align="left"><FONT size="2">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;We have a policy of directors and officers liability insurance that
insures us and our directors and officers against damages, settlements, and
defense costs under certain circumstances.
</FONT>

<P align="center"><FONT size="2">&nbsp;</FONT>

<!-- PAGEBREAK -->
<P><HR noshade><P>
<H5 align="left" style="page-break-before:always"><A HREF="#toc">Table of Contents</A></H5><P>
<!-- link2 "Item&nbsp;8. Exhibits." -->
<DIV align="left"><A NAME="003"></A></DIV>

<P align="left"><FONT size="2"><B>Item&nbsp;8. Exhibits</B>.
</FONT>

<P align="left"><FONT size="2">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Pursuant to General Instruction E, only those opinions and consents
required by Item&nbsp;8 are provided. They are as follows:
</FONT>

<CENTER>
<TABLE cellspacing="0" border="0" cellpadding="0" width="65%">
<TR valign="bottom">
    <TD width="8%">&nbsp;</TD>
    <TD width="5%">&nbsp;</TD>
    <TD width="87%">&nbsp;</TD>
</TR>
<TR valign="bottom">
    <TD nowrap align="center"><FONT size="1"><B>Exhibit</B></FONT></TD>
    <TD><FONT size="1">&nbsp;</FONT></TD>
    <TD><FONT size="1">&nbsp;</FONT></TD>
</TR>
<TR valign="bottom">
    <TD nowrap align="center"><FONT size="1"><B>Number</B></FONT></TD>
    <TD><FONT size="1">&nbsp;</FONT></TD>
    <TD nowrap align="center"><FONT size="1"><B>Description</B></FONT></TD>
</TR>
<TR valign="bottom">
    <TD nowrap align="center"><HR size="1" noshade></TD>
    <TD><FONT size="1">&nbsp;</FONT></TD>
    <TD nowrap align="center"><HR size="1" noshade></TD>
</TR>
<TR valign="bottom">
    <TD valign="top" align="center"><FONT size="2">5.1</FONT></TD>
    <TD><FONT size="2">&nbsp;</FONT></TD>
    <TD align="left" valign="top"><FONT size="2">
Opinion of Gibson, Dunn &#038; Crutcher LLP</FONT></TD>
</TR>

<TR valign="bottom">
    <TD valign="top" align="center"><FONT size="2">23.1</FONT></TD>
    <TD><FONT size="2">&nbsp;</FONT></TD>
    <TD align="left" valign="top"><FONT size="2">
Consent of Ernst &#038; Young LLP, independent auditors</FONT></TD>
</TR>

<TR valign="bottom">
    <TD valign="top" align="center"><FONT size="2">23.2</FONT></TD>
    <TD><FONT size="2">&nbsp;</FONT></TD>
    <TD align="left" valign="top"><FONT size="2">
Consent of Gibson, Dunn &#038; Crutcher LLP (contained in Exhibit&nbsp;5.1
hereto)</FONT></TD>
</TR>

<TR valign="bottom">
    <TD valign="top" align="center"><FONT size="2">24.1</FONT></TD>
    <TD><FONT size="2">&nbsp;</FONT></TD>
    <TD align="left" valign="top"><FONT size="2">
Power of Attorney (contained on signature page hereto)</FONT></TD>
</TR>
</TABLE>
</CENTER>
<P align="center"><FONT size="2">&nbsp;</FONT>

<!-- PAGEBREAK -->
<P><HR noshade><P>
<H5 align="left" style="page-break-before:always"><A HREF="#toc">Table of Contents</A></H5><P>
<!-- link1 "SIGNATURES" -->
<DIV align="left"><A NAME="004"></A></DIV>

<P align="center"><FONT size="2"><B>SIGNATURES</B>
</FONT>

<P align="left"><FONT size="2">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Pursuant to the requirements of the Securities Act of 1933, the registrant
certifies that it has reasonable grounds to believe that it meets all of the
requirements for filing on Form&nbsp;S-8 and has duly caused this registration
statement to be signed on its behalf by the undersigned, thereunto duly
authorized, in the City of San Diego, State of California, on this
11th day of
June 2003.
</FONT>

<CENTER>
<TABLE cellspacing="0" border="0" cellpadding="0" width="55%">
<TR valign="bottom">
    <TD width="15%">&nbsp;</TD>
    <TD width="5%">&nbsp;</TD>
    <TD width="3%">&nbsp;</TD>
    <TD width="5%">&nbsp;</TD>
    <TD width="72%">&nbsp;</TD>
</TR>
<TR valign="bottom">
    <TD valign="top"><FONT size="2">&nbsp;</FONT></TD>
    <TD><FONT size="2">&nbsp;</FONT></TD>
    <TD colspan="3" align="left" valign="top"><FONT size="2"><B>LA JOLLA PHARMACEUTICAL COMPANY</B></FONT></TD>
</TR>

<TR valign="bottom">
    <TD valign="top"><FONT size="2">&nbsp;</FONT></TD>
    <TD><FONT size="2">&nbsp;</FONT></TD>
    <TD align="left" valign="top"><FONT size="2">&nbsp;</FONT></TD>
    <TD><FONT size="2">&nbsp;</FONT></TD>
    <TD align="left" valign="top"><FONT size="2">&nbsp;</FONT></TD>
</TR>

<TR valign="bottom">
    <TD valign="top"><FONT size="2">&nbsp;</FONT></TD>
    <TD><FONT size="2">&nbsp;</FONT></TD>
    <TD align="left" valign="top"><FONT size="2">
By:</FONT></TD>
    <TD><FONT size="2">&nbsp;</FONT></TD>
    <TD align="left" valign="top"><FONT size="2">/s/ Steven B.
Engle</FONT></TD>
</TR>
<TR>
    <TD valign="top"><FONT size="2">&nbsp;</FONT></TD>
    <TD><FONT size="2">&nbsp;</FONT></TD>
    <TD align="left" valign="top"><FONT size="2">&nbsp;</FONT></TD>
    <TD><FONT size="2">&nbsp;</FONT></TD>
    <TD align="left" valign="top"><HR size="1" noshade></TD>
</TR>
<TR valign="bottom">
    <TD valign="top"><FONT size="2">&nbsp;</FONT></TD>
    <TD><FONT size="2">&nbsp;</FONT></TD>
    <TD align="left" valign="top"><FONT size="2">&nbsp;</FONT></TD>
    <TD><FONT size="2">&nbsp;</FONT></TD>
    <TD align="left" valign="top"><FONT size="2">Steven B. Engle</FONT></TD>
</TR>

<TR valign="bottom">
    <TD valign="top"><FONT size="2">&nbsp;</FONT></TD>
    <TD><FONT size="2">&nbsp;</FONT></TD>
    <TD align="left" valign="top"><FONT size="2">&nbsp;</FONT></TD>
    <TD><FONT size="2">&nbsp;</FONT></TD>
    <TD align="left" valign="top"><FONT size="2">Chairman and Chief Executive Officer</FONT></TD>
</TR>
</TABLE>
</CENTER>

<P align="center"><FONT size="2"><B>POWER OF ATTORNEY</B>
</FONT>

<P align="left"><FONT size="2">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Each person whose signature appears below constitutes and appoints Steven
B. Engle and Gail A. Sloan his or her true and lawful attorneys-in-fact and
agents, each acting alone, with full powers of substitution and resubstitution,
for him or her and in his or her name, place and stead, in any and all
capacities, to sign any and all amendments (including post-effective
amendments) to this registration statement and to file the same, with all
exhibits thereto, and other documents in connection therewith, with the
Securities and Exchange Commission, granting unto said attorneys-in-fact and
agents, each acting alone, full power and authority to do and perform each and
every act and thing requisite and necessary to be done in and about the
premises, as full to all intents and purposes as he or she might or could do in
person, hereby ratifying and confirming all that said attorneys-in-fact and
agents, each acting alone, or his or her substitute or substitutes, may
lawfully do or cause to be done by virtue hereof.
</FONT>

<P align="left"><FONT size="2">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Pursuant to the requirements of the Securities Act of 1933, this
registration statement has been signed by the following persons in the
capacities on the date indicated.
</FONT>

<CENTER>
<TABLE cellspacing="0" border="0" cellpadding="0" width="75%">
<TR valign="bottom">
    <TD width="35%">&nbsp;</TD>
    <TD width="5%">&nbsp;</TD>
    <TD width="35%">&nbsp;</TD>
    <TD width="5%">&nbsp;</TD>
    <TD width="20%">&nbsp;</TD>
</TR>
<TR valign="bottom">
    <TD nowrap align="center"><FONT size="1"><B>Signature</B></FONT></TD>
    <TD><FONT size="1">&nbsp;</FONT></TD>
    <TD nowrap align="center"><FONT size="1"><B>Title</B></FONT></TD>
    <TD><FONT size="1">&nbsp;</FONT></TD>
    <TD nowrap align="center"><FONT size="1"><B>Date</B></FONT></TD>
</TR>
<TR valign="bottom">
    <TD nowrap align="center"><HR size="1" noshade></TD>
    <TD><FONT size="1">&nbsp;</FONT></TD>
    <TD nowrap align="center"><HR size="1" noshade></TD>
    <TD><FONT size="1">&nbsp;</FONT></TD>
    <TD nowrap align="center"><HR size="1" noshade></TD>
</TR>
<TR valign="bottom">
    <TD valign="top" align="center"><FONT size="2">/s/ Steven B.
Engle<BR>
<HR size="1" noshade>
Steven B. Engle</FONT></TD>
    <TD><FONT size="2">&nbsp;</FONT></TD>
    <TD align="center" valign="top"><FONT size="2">
Chairman and<BR>
Chief Executive Officer<BR>
(Principal Executive Officer)
</FONT></TD>
    <TD><FONT size="2">&nbsp;</FONT></TD>
    <TD align="center" valign="top"><FONT size="2">June 11, 2003</FONT></TD>
</TR>
<TR><TD><FONT size="2">&nbsp;</FONT></TD></TR>
<TR valign="bottom">
    <TD valign="top" align="center"><FONT size="2"><BR>
/s/ Gail A. Sloan<BR>
</FONT>
<HR size="1" noshade><FONT size="2">
Gail A. Sloan</FONT></TD>
    <TD><FONT size="2">&nbsp;</FONT></TD>
    <TD align="center" valign="top"><FONT size="2">
Senior Director of Finance,<BR>
Controller and Secretary<BR>
(Principal Financial and<BR>
Accounting Officer)
</FONT></TD>
    <TD><FONT size="2">&nbsp;</FONT></TD>
    <TD align="center" valign="top"><FONT size="2">June 11, 2003</FONT></TD>
</TR>
<TR><TD><FONT size="2">&nbsp;</FONT></TD></TR>
<TR valign="bottom">
    <TD valign="top" align="center"><FONT size="2">&nbsp;<BR>
</FONT>
<HR size="1" noshade><FONT size="2">
Thomas H. Adams, Ph.D.</FONT></TD>
    <TD><FONT size="2">&nbsp;</FONT></TD>
    <TD align="center" valign="top"><FONT size="2">
Director
</FONT></TD>
    <TD><FONT size="2">&nbsp;</FONT></TD>
    <TD align="center" valign="top"><FONT size="2">&nbsp;</FONT></TD>
</TR>
<TR><TD><FONT size="2">&nbsp;</FONT></TD></TR>
<TR valign="bottom">
    <TD valign="top" align="center"><FONT size="2">/s/ William E.
Engbers<BR>
</FONT>
<HR size="1" noshade><FONT size="2">
William E. Engbers</FONT></TD>
    <TD><FONT size="2">&nbsp;</FONT></TD>
    <TD align="center" valign="top"><FONT size="2">
Director
</FONT></TD>
    <TD><FONT size="2">&nbsp;</FONT></TD>
    <TD align="center" valign="top"><FONT size="2">June 11, 2003</FONT></TD>
</TR>
<TR><TD><FONT size="2">&nbsp;</FONT></TD></TR>
<TR valign="bottom">
    <TD valign="top" align="center"><FONT size="2">/s/ Robert A.
Fildes<BR>
</FONT>
<HR size="1" noshade><FONT size="2">
Robert A. Fildes, Ph.D.</FONT></TD>
    <TD><FONT size="2">&nbsp;</FONT></TD>
    <TD align="center" valign="top"><FONT size="2">
Director
</FONT></TD>
    <TD><FONT size="2">&nbsp;</FONT></TD>
    <TD align="center" valign="top"><FONT size="2">June 11, 2003</FONT></TD>
</TR>
</TABLE>
</CENTER>
<P align="center"><FONT size="2">&nbsp;</FONT>

<!-- PAGEBREAK -->
<P><HR noshade><P>
<H5 align="left" style="page-break-before:always"><A HREF="#toc">Table of Contents</A></H5><P>
<CENTER>
<TABLE cellspacing="0" border="0" cellpadding="0" width="75%">
<TR valign="bottom">
    <TD width="35%">&nbsp;</TD>
    <TD width="5%">&nbsp;</TD>
    <TD width="35%">&nbsp;</TD>
    <TD width="5%">&nbsp;</TD>
    <TD width="20%">&nbsp;</TD>
</TR>
<TR valign="bottom">
    <TD nowrap align="center"><FONT size="1"><B>Signature</B></FONT></TD>
    <TD><FONT size="1">&nbsp;</FONT></TD>
    <TD nowrap align="center"><FONT size="1"><B>Title</B></FONT></TD>
    <TD><FONT size="1">&nbsp;</FONT></TD>
    <TD nowrap align="center"><FONT size="1"><B>Date</B></FONT></TD>
</TR>
<TR valign="bottom">
    <TD nowrap align="center"><HR size="1" noshade></TD>
    <TD><FONT size="1">&nbsp;</FONT></TD>
    <TD nowrap align="center"><HR size="1" noshade></TD>
    <TD><FONT size="1">&nbsp;</FONT></TD>
    <TD nowrap align="center"><HR size="1" noshade></TD>
</TR>
<TR><TD><FONT size="2">&nbsp;</FONT></TD></TR>
<TR valign="bottom">
    <TD valign="top" align="center"><FONT size="2">/s/ Stephen M. Martin<BR>
</FONT>
<HR size="1" noshade><FONT size="2">
Stephen M. Martin</FONT></TD>
    <TD><FONT size="2">&nbsp;</FONT></TD>
    <TD align="center" valign="top"><FONT size="2">
Director
</FONT></TD>
    <TD><FONT size="2">&nbsp;</FONT></TD>
    <TD align="center" valign="top"><FONT size="2">June 11, 2003</FONT></TD>
</TR>
<TR><TD><FONT size="2">&nbsp;</FONT></TD></TR>
<TR valign="bottom">
    <TD valign="top" align="center"><FONT size="2">/s/ William R. Ringo<BR>
</FONT>
<HR size="1" noshade><FONT size="2">
William R. Ringo</FONT></TD>
    <TD><FONT size="2">&nbsp;</FONT></TD>
    <TD align="center" valign="top"><FONT size="2">
Director
</FONT></TD>
    <TD><FONT size="2">&nbsp;</FONT></TD>
    <TD align="center" valign="top"><FONT size="2">June 11, 2003</FONT></TD>
</TR>
<TR><TD><FONT size="2">&nbsp;</FONT></TD></TR>
<TR valign="bottom">
    <TD valign="top" align="center"><FONT size="2">/s/ W. Leigh Thompson<BR>
</FONT>
<HR size="1" noshade><FONT size="2">
W. Leigh Thompson, M.D., Ph.D.</FONT></TD>
    <TD><FONT size="2">&nbsp;</FONT></TD>
    <TD align="center" valign="top"><FONT size="2">
Director
</FONT></TD>
    <TD><FONT size="2">&nbsp;</FONT></TD>
    <TD align="center" valign="top"><FONT size="2">June 11, 2003</FONT></TD>
</TR>
</TABLE>
</CENTER>
<P align="center"><FONT size="2">&nbsp;</FONT>

<!-- PAGEBREAK -->
<P><HR noshade><P>
<H5 align="left" style="page-break-before:always"><A HREF="#toc">Table of Contents</A></H5><P>
<!-- link1 "EXHIBIT INDEX" -->
<DIV align="left"><A NAME="005"></A></DIV>

<P align="center"><FONT size="2"><B>EXHIBIT INDEX</B>
</FONT>

<CENTER>
<TABLE cellspacing="0" border="0" cellpadding="0" width="75%">
<TR valign="bottom">
    <TD width="8%">&nbsp;</TD>
    <TD width="5%">&nbsp;</TD>
    <TD width="87%">&nbsp;</TD>
</TR>
<TR valign="bottom">
    <TD nowrap align="center"><FONT size="1"><B>Exhibit</B></FONT></TD>
    <TD><FONT size="1">&nbsp;</FONT></TD>
    <TD><FONT size="1">&nbsp;</FONT></TD>
</TR>
<TR valign="bottom">
    <TD nowrap align="center"><FONT size="1"><B>Number</B></FONT></TD>
    <TD><FONT size="1">&nbsp;</FONT></TD>
    <TD nowrap align="center"><FONT size="1"><B>Description</B></FONT></TD>
</TR>
<TR valign="bottom">
    <TD nowrap align="center"><HR size="1" noshade></TD>
    <TD><FONT size="1">&nbsp;</FONT></TD>
    <TD nowrap align="center"><HR size="1" noshade></TD>
</TR>
<TR valign="bottom">
    <TD valign="top" align="center"><FONT size="2">5.1</FONT></TD>
    <TD><FONT size="2">&nbsp;</FONT></TD>
    <TD align="left" valign="top"><FONT size="2">
Opinion of Gibson, Dunn &#038; Crutcher LLP</FONT></TD>
</TR>

<TR valign="bottom">
    <TD valign="top" align="center"><FONT size="2">23.1</FONT></TD>
    <TD><FONT size="2">&nbsp;</FONT></TD>
    <TD align="left" valign="top"><FONT size="2">
Consent of Ernst &#038; Young LLP, independent auditors</FONT></TD>
</TR>

<TR valign="bottom">
    <TD valign="top" align="center"><FONT size="2">23.2</FONT></TD>
    <TD><FONT size="2">&nbsp;</FONT></TD>
    <TD align="left" valign="top"><FONT size="2">
Consent of Gibson, Dunn &#038; Crutcher LLP (contained in Exhibit&nbsp;5.1 hereto)</FONT></TD>
</TR>

<TR valign="bottom">
    <TD valign="top" align="center"><FONT size="2">24.1</FONT></TD>
    <TD><FONT size="2">&nbsp;</FONT></TD>
    <TD align="left" valign="top"><FONT size="2">
Power of Attorney (contained on signature page hereto)</FONT></TD>
</TR>
</TABLE>
</CENTER>


<P align="center"><FONT size="2">&nbsp;</FONT>



</BODY>
</HTML>
[{"type": "S-8", "sequence": "1", "filename": "a90848sv8.htm", "description": "FORM S-8", "secsgml_size_bytes": 38771}]
{"company-data": {"conformed-name": "LA JOLLA PHARMACEUTICAL CO", "cik": "0000920465", "assigned-sic": "2836", "irs-number": "330361285", "state-of-incorporation": "DE", "fiscal-year-end": "1231"}, "filing-values": {"form-type": "S-8", "act": "33", "file-number": "333-106060", "film-number": "03742169"}, "business-address": {"street1": "6455 NANCY RIDGE DR", "city": "SAN DIEGO", "state": "CA", "zip": "92121", "phone": "8584526600"}, "mail-address": {"street1": "6455 NANCY RIDGE DR", "city": "SAN DIEGO", "state": "CA", "zip": "92121"}}
La Jolla Pharmaceutical Company
Table of Contents
As filed with the Securities and
Exchange Commission on June 12, 2003. Registration No. 333-_____________
UNITED STATES
SECURITIES AND EXCHANGE COMMISSION
WASHINGTON, DC 20549
FORM S-8
REGISTRATION STATEMENT
UNDER
THE SECURITIES ACT OF 1933
LA JOLLA PHARMACEUTICAL COMPANY
(Exact Name of Registrant as Specified in Its Charter)
Delaware
33-0361285
(State or Other Jurisdiction of
Incorporation or Organization)
(I.R.S. Employer Identification No.)
6455 Nancy Ridge Drive
San Diego, California 92121
(Address, including Zip Code, of Principal Executive Offices)
LA JOLLA PHARMACEUTICAL COMPANY 1994 STOCK INCENTIVE PLAN
(Full Title of the Plan)
Steven B. Engle
La Jolla Pharmaceutical Company
6455 Nancy Ridge Drive
San Diego, California 92121
(858) 452-6600
(Name, address, and telephone number, including area code, of Agent For Service)
Copy to:
Mark W. Shurtleff, Esq.
Gibson, Dunn & Crutcher LLP
4 Park Plaza, Suite 1700
Irvine, California 92614
(949) 451-3800
Table of Contents
CALCULATION OF REGISTRATION FEE
PROPOSED
PROPOSED
TITLE OF
MAXIMUM
MAXIMUM
SECURITIES
AMOUNT TO BE
OFFERING PRICE
AGGREGATE
AMOUNT OF
TO BE REGISTERED
REGISTERED(1)
PER SHARE(2)
OFFERING PRICE(2)
REGISTRATION FEE
Common Stock, par value $0.01 per share
1,100,000
(3)
$
3.76
$
4,136,000
$
335
(1)
Each share of common stock includes a right to purchase one
one-thousandth of a share of Series A Junior Participating Preferred Stock
pursuant to the Rights Agreement between the Registrant and American Stock
Transfer & Trust Company, as Rights Agent, as amended. Pursuant to Rule
416(a), this Registration Statement also covers shares of common stock
which may be issued pursuant to antidilution provisions contained in the
La Jolla Pharmaceutical Company 1994 Stock Incentive Plan.
(2)
Estimated solely for the purpose of calculating the registration fee
pursuant to Rules 457(c) and 457(h) and based on the average of the high
and the low price of the common stock of the registrant as reported on
June 5, 2003 on the Nasdaq National Market System.
(3)
Represents a 1,100,000 share increase in the number of shares authorized
for issuance under the La Jolla Pharmaceutical Company 1994 Stock
Incentive Plan. 8,200,000 shares of our common stock are issuable under
the 1994 Stock Incentive Plan. In addition to the shares of common stock
registered hereby, 750,000 shares of our common stock issuable under the
1994 Stock Incentive Plan were previously registered under the
Registration Statement on Form S-8 (Registration No. 33-82664) as filed
with the Securities and Exchange Commission on August 11, 1994; 500,000
shares of our common stock issuable under the 1994 Stock Incentive Plan
were previously registered under the Registration Statement on Form S-8
(Registration No. 333-14285) as filed with the Securities and Exchange
Commission on October 17, 1996; 500,000 shares of our common stock
issuable under the 1994 Stock Incentive Plan were previously registered
under the Registration Statement on Form S-8 (Registration No. 333-29575)
as filed with the Securities and Exchange Commission on June 19, 1997;
750,000 shares of our common stock issuable under the 1994 Stock Incentive
Plan were previously registered under the Registration Statement on Form
S-8 (Registration No. 333-91593) as filed with the Securities and Exchange
Commission on November 24, 1999; 1,000,000 shares of our common stock
issuable under the 1994 Stock Incentive Plan were previously registered
under the Registration Statement on Form S-8 (Registration No. 333-45080)
as filed with the Securities and Exchange Commission on September 1, 2000;
1,700,000 shares of our common stock issuable under the 1994 Stock
Incentive Plan were previously registered under the Registration Statement
on Form S-8 (Registration No. 333-69104) as filed with the Securities and
Exchange Commission on September 7, 2001; and 1,900,000 shares of our
common stock issuable under the 1994 Stock Incentive Plan were previously
registered under the Registration Statement on Form S-8 (Registration No.
333-89980) as filed with the Securities and Exchange Commission on June 6,
2002.
TABLE OF CONTENTS
PART I
PART II
Item 6. Indemnification of Officers and Directors
Item 8. Exhibits.
SIGNATURES
EXHIBIT INDEX
EXHIBIT 5.1
EXHIBIT 23.1
Table of Contents
INTRODUCTION
We are filing this Registration Statement on Form S-8 to register an
additional 1,100,000 shares of our common stock that we may issue under the La
Jolla Pharmaceutical Company 1994 Stock Incentive Plan. We have included in
this Registration Statement only those items required by General Instruction E
to Form S-8.
PART I
INFORMATION REQUIRED IN THE SECTION 10(a) PROSPECTUS
Information required by Part I of Form S-8 to be contained in the Section
10(a) prospectus is omitted from this Registration Statement in accordance with
Rule 428 under the Securities Act of 1933, as amended, and the Note to Part I
of Form S-8.
PART II
INFORMATION REQUIRED IN THE REGISTRATION STATEMENT
In accordance with General Instruction E to Form S-8, the contents of our
Registration Statement on Form S-8 (Registration No. 33-82664) previously filed
by us with the Securities and Exchange Commission on August 11, 1994 relating
to the 1994 Stock Incentive Plan is incorporated herein by reference and made a
part hereof. In addition, the contents of our Registration Statement on Form
S-8 (Registration No. 333-69104) previously filed by us with the Securities and
Exchange Commission on September 7, 2001, which Registration Statement contains
updated information under the heading "Undertakings," is incorporated herein by
reference and made a part hereof.
Item 6. Indemnification of Officers and Directors
Section 145(a) of the General Corporation Law of the State of Delaware
(the "DGCL") provides that a Delaware corporation may indemnify any person who
was or is a party or is threatened to be made a party to any threatened,
pending or completed action, suit or proceeding, whether civil, criminal,
administrative or investigative, other than an action by or in the right of the
corporation, by reason of the fact that such person is or was a director,
officer, employee or agent of the corporation or is or was serving at the
request of the corporation as a director, officer, employee or agent of another
corporation or enterprise, against expenses, judgments, fines and amounts paid
in settlement actually and reasonably incurred by such person in connection
with such action, suit or proceeding if he or she acted in good faith and in a
manner he or she reasonably believed to be in or not opposed to the best
interests of the corporation, and, with respect to any criminal action or
proceeding, had no cause to believe his or her conduct was unlawful.
Section 145(b) of the DGCL provides that a Delaware corporation may
indemnify any person who was or is a party or is threatened to be made a party
to any threatened, pending or completed action or suit by or in the right of
the corporation to procure a judgment in its favor by reason of the fact that
such person acted in any of the capacities set forth above, against expenses
actually and reasonably incurred by such person in connection with the defense
or settlement of such action or suit if he or she acted under similar standards
to those set forth above, except that no indemnification may be made in respect
to any claim, issue or matter as to which such person shall have been adjudged
to be liable to the corporation unless and only to the extent that the court in
which such action or suit was brought shall determine that despite the
adjudication of liability, but in view of all the circumstances of the case,
such person is fairly and reasonably entitled to be indemnified for such
expenses which the court shall deem proper.
Section 145 of the DGCL further provides that to the extent a director or
officer of a corporation has been successful in the defense of any action, suit
or proceeding referred to in subsection (a) and (b) of Section 145 or in the
defense of any claim, issue or matter therein, he or she shall be indemnified
against expenses actually and reasonably incurred by him or her in connection
therewith; that indemnification provided for by Section 145 shall not be deemed
exclusive of any other rights to which the indemnified party may be entitled;
and that the corporation may purchase and maintain insurance on behalf of a
director or officer of the corporation against any liability asserted against
such officer or director and incurred by him or her in any such capacity or
arising out of his or her
Table of Contents
status as such, whether or not the corporation would have the power to
indemnify him or her against such liabilities under Section 145.
As permitted by Section 102(b)(7) of the DGCL our certificate of
incorporation provides that a director shall not be liable to us or our
stockholders for monetary damages for breach of fiduciary duty as a director.
However, such provision does not eliminate or limit the liability of a director
for acts or omissions not in good faith or for breaching his or her duty of
loyalty, engaging in intentional misconduct, knowingly violating the law,
paying an illegal dividend, approving an illegal stock repurchase, or obtaining
an improper personal benefit. A provision of this type has no effect on the
availability of equitable remedies, such as injunction or rescission, for
breach of fiduciary duty.
Our bylaws require that directors and officers be indemnified to the
maximum extent permitted by Delaware law.
We have entered into indemnity agreements with each of our directors and
executive officers. These indemnity agreements generally require that we pay
on behalf of each director and officer party thereto all amounts that he or she
is or becomes legally obligated to pay because of any claim or claims made
against him or her because of any act or omission or which he or she commits or
suffers while acting in his or her capacity as our director and/or officer and
because of his or her being a director and/or officer. Under the DGCL, absent
an indemnity agreement or a provision in a corporation's bylaws or certificate
of incorporation, indemnification of a director or officer is discretionary
rather than mandatory (except in the case of a proceeding in which a director
or officer is successful on the merits). In addition, if indemnification is
unavailable and may not be paid to an officer or director, we have agreed,
subject to a limited number of exceptions, to contribute to the amount of
expenses incurred or payable by the officer or director, to the extent allowed
by applicable law, in such proportion as is appropriate to reflect the relative
benefits received by us, on the one hand, and by the officer or director, on
the other, from the transaction from which the proceeding arose and the
relative faults of the parties, as well as any other applicable equitable
considerations.
Consistent with our bylaw provision on the subject, the indemnity
agreements require us to make prompt payment of defense and investigation costs
and expenses at the request of the director or officer in advance of
indemnification, provided that the recipient undertakes to repay the amounts if
it is ultimately determined that he or she is not entitled to indemnification
for such expenses and provided further that such advance shall not be made if
it is determined that the director or officer would not be permitted to be
indemnified under applicable law. The indemnity agreements make the advance of
litigation expenses mandatory absent a special determination to the contrary.
Under the DGCL, absent an indemnity agreement or a provision in a corporation's
bylaws or certificate of incorporation, the advancement of expenses is
discretionary. Under the indemnity agreement, the director or officer is
permitted to petition the court to seek recovery of amounts due under the
indemnity agreement and to recover the expenses of seeking such recovery if he
or she is successful. The benefits of the indemnity agreement will not be
available to the extent that an officer or director has other indemnification
or insurance coverage for the subject claim. In addition, no indemnity will be
paid by us: with respect to remuneration paid to an officer or director if it
is determined by a final judgment that such remuneration was in violation of
law; on account of any suit or judgment rendered against an officer or director
for violating Section 16(b) of the Securities Exchange Act of 1934, or
analogous provisions of law; if an officer's or director's conduct
is adjudged to be fraudulent or deliberately dishonest, or constitutes willful misconduct; or (iv) if it is adjudged that indemnification
is not lawful. Absent the indemnity agreement, indemnification that might be
made available to directors and officers could be changed by amendments to our
certificate of incorporation or bylaws.
We have a policy of directors and officers liability insurance that
insures us and our directors and officers against damages, settlements, and
defense costs under certain circumstances.
Table of Contents
Item 8. Exhibits
.
Pursuant to General Instruction E, only those opinions and consents
required by Item 8 are provided. They are as follows:
Exhibit
Number
Description
5.1
Opinion of Gibson, Dunn & Crutcher LLP
23.1
Consent of Ernst & Young LLP, independent auditors
23.2
Consent of Gibson, Dunn & Crutcher LLP (contained in Exhibit 5.1
hereto)
24.1
Power of Attorney (contained on signature page hereto)
Table of Contents
SIGNATURES
Pursuant to the requirements of the Securities Act of 1933, the registrant
certifies that it has reasonable grounds to believe that it meets all of the
requirements for filing on Form S-8 and has duly caused this registration
statement to be signed on its behalf by the undersigned, thereunto duly
authorized, in the City of San Diego, State of California, on this
11th day of
June 2003.
LA JOLLA PHARMACEUTICAL COMPANY
By:
/s/ Steven B.
Engle
Steven B. Engle
Chairman and Chief Executive Officer
POWER OF ATTORNEY
Each person whose signature appears below constitutes and appoints Steven
B. Engle and Gail A. Sloan his or her true and lawful attorneys-in-fact and
agents, each acting alone, with full powers of substitution and resubstitution,
for him or her and in his or her name, place and stead, in any and all
capacities, to sign any and all amendments (including post-effective
amendments) to this registration statement and to file the same, with all
exhibits thereto, and other documents in connection therewith, with the
Securities and Exchange Commission, granting unto said attorneys-in-fact and
agents, each acting alone, full power and authority to do and perform each and
every act and thing requisite and necessary to be done in and about the
premises, as full to all intents and purposes as he or she might or could do in
person, hereby ratifying and confirming all that said attorneys-in-fact and
agents, each acting alone, or his or her substitute or substitutes, may
lawfully do or cause to be done by virtue hereof.
Pursuant to the requirements of the Securities Act of 1933, this
registration statement has been signed by the following persons in the
capacities on the date indicated.
Signature
Title
Date
/s/ Steven B.
Engle
Steven B. Engle
Chairman and
Chief Executive Officer
(Principal Executive Officer)
June 11, 2003
/s/ Gail A. Sloan
Gail A. Sloan
Senior Director of Finance,
Controller and Secretary
(Principal Financial and
Accounting Officer)
June 11, 2003
Thomas H. Adams, Ph.D.
Director
/s/ William E.
Engbers
William E. Engbers
Director
June 11, 2003
/s/ Robert A.
Fildes
Robert A. Fildes, Ph.D.
Director
June 11, 2003
Table of Contents
Signature
Title
Date
/s/ Stephen M. Martin
Stephen M. Martin
Director
June 11, 2003
/s/ William R. Ringo
William R. Ringo
Director
June 11, 2003
/s/ W. Leigh Thompson
W. Leigh Thompson, M.D., Ph.D.
Director
June 11, 2003
Table of Contents
EXHIBIT INDEX
Exhibit
Number
Description
5.1
Opinion of Gibson, Dunn & Crutcher LLP
23.1
Consent of Ernst & Young LLP, independent auditors
23.2
Consent of Gibson, Dunn & Crutcher LLP (contained in Exhibit 5.1 hereto)
24.1
Power of Attorney (contained on signature page hereto)