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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>As filed with the Securities and Exchange
Commission on August 21, 2020</B></P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: right"><B>&#9;Registration No.&nbsp;333-</B></P>

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<P STYLE="font: 11pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>UNITED STATES</B></P>

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<P STYLE="font: 11pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>SECURITIES AND EXCHANGE COMMISSION</B>&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>Washington, D.C. 20549</B></P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><U>_____________________</U></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: 14pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>FORM S-8</B></P>

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<P STYLE="font: 14pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>REGISTRATION STATEMENT UNDER THE SECURITIES
ACT OF 1933</B></P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><U>______________________</U></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: 14pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>SMITH &amp; NEPHEW plc</B></P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">(Exact Name of Registrant as Specified in
Its Charter)</P>

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<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
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    <TD STYLE="width: 50%; font-size: 10pt; text-align: center"><FONT STYLE="font-size: 10pt"><B>England &amp; Wales</B></FONT></TD>
    <TD STYLE="width: 50%; font-size: 10pt; text-align: center"><FONT STYLE="font-size: 10pt"><B>None</B></FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="font-size: 10pt; text-align: center"><FONT STYLE="font-size: 10pt">(State or Other Jurisdiction<BR>
of Incorporation or Organization)</FONT></TD>
    <TD STYLE="font-size: 10pt; text-align: center"><FONT STYLE="font-size: 10pt">(I.R.S. Employer<BR>
Identification No.)</FONT></TD></TR>
</TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>&nbsp;</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>Building 5, Croxley Park, Hatters Lane,
Watford, Hertfordshire WD18 8YE, England</B>&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">(Address of Principal Executive Offices)</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>The Smith &amp; Nephew Global Share Plan
2020</B></P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">(Full Title of the Plans)</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><U>______________________</U></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>Smith &amp; Nephew, Inc.</B></P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>150 Minuteman Road</B></P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>Andover, MA 01810</B></P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">(Name and Address of Agent For Service)</P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>(978) 749-1000</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;<I>&#9;(Telephone Number, including
area code, of agent for service)</I></P>

<P STYLE="text-align: center; font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt">&nbsp;<U>______________________</U></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B><I>Copies to:</I></B></P>

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    <TD STYLE="width: 50%">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>John Meade, Esq.</B></P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"></P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>Davis Polk &amp; Wardwell LLP</B></P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;<B>450 Lexington Avenue</B></P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"></P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>New York, New York 10017</B></P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;<B>(212) 450-4000</B></P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"></P></TD>
    <TD STYLE="width: 50%">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>Kyoko Takahashi Lin, Esq.</B></P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"></P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>Davis Polk &amp; Wardwell LLP</B></P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"></P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>450 Lexington Avenue</B></P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"></P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>New York, New York 10017</B></P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"></P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>(212) 450-4000</B></P></TD></TR>
</TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><U>______________________</U></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B>Indicate by check mark whether the Registrant is a large
accelerated filer, an accelerated filer, a non-accelerated filer, a smaller reporting company or an emerging growth company. See
definitions of &ldquo;large accelerated filer,&rdquo; &ldquo;accelerated filer,&rdquo; &ldquo;smaller reporting company,&rdquo;
and &ldquo;emerging growth company&rdquo; in Rule 12b-2 of the Exchange Act.</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
<TR>
    <TD STYLE="vertical-align: top; width: 17%"><FONT STYLE="font-size: 10pt">Large&nbsp;accelerated&nbsp;filer</FONT></TD>
    <TD STYLE="vertical-align: top; width: 55%"><FONT STYLE="font-family: Wingdings; font-size: 10pt">x</FONT></TD>
    <TD STYLE="vertical-align: top; width: 26%"><FONT STYLE="font-size: 10pt">Accelerated&nbsp;filer</FONT></TD>
    <TD STYLE="vertical-align: bottom; width: 2%"><FONT STYLE="font-family: Wingdings; font-size: 10pt">&uml;</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD><FONT STYLE="font-size: 10pt">Non-accelerated filer</FONT></TD>
    <TD><FONT STYLE="font-family: Wingdings; font-size: 10pt">&uml;</FONT></TD>
    <TD><FONT STYLE="font-size: 10pt">Smaller&nbsp;reporting&nbsp;company</FONT></TD>
    <TD><FONT STYLE="font-family: Wingdings; font-size: 10pt">&uml;</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD><FONT STYLE="font-size: 10pt">Emerging growth company</FONT></TD>
    <TD><FONT STYLE="font-family: Wingdings; font-size: 10pt">&uml;</FONT></TD></TR>
</TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">If an emerging growth company, indicate by check mark if the
registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards
provided pursuant to Section 7(a)(2)(B) of the Securities Act. <FONT STYLE="font-family: Wingdings">&uml;</FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>


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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>CALCULATION OF REGISTRATION FEE</B></P>

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    <TD STYLE="padding-right: 4pt; width: 35%; border-top: Black 2.25pt solid; border-right: Black 1pt solid; border-bottom: Black 1pt solid; padding-left: 4pt">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B><BR>
        Title of Securities</B></P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"></P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>To Be Registered</B>&nbsp;</P></TD>
    <TD STYLE="padding-right: 4pt; width: 13%; border-top: Black 2.25pt solid; border-right: Black 1pt solid; border-bottom: Black 1pt solid; text-align: center; padding-left: 4pt"><FONT STYLE="font-size: 10pt"><B>Amount To Be<BR>
Registered (2)</B></FONT></TD>
    <TD STYLE="padding-right: 4pt; width: 16%; border-top: Black 2.25pt solid; border-right: Black 1pt solid; border-bottom: Black 1pt solid; text-align: center; padding-left: 4pt"><FONT STYLE="font-size: 10pt"><B>Proposed Maximum Offering Price<BR>
Per Share (3) (4)</B></FONT></TD>
    <TD STYLE="padding-right: 4pt; width: 15%; border-top: Black 2.25pt solid; border-right: Black 1pt solid; border-bottom: Black 1pt solid; text-align: center; padding-left: 4pt"><FONT STYLE="font-size: 10pt"><B>Proposed Maximum Aggregate Offering Price (3) (4)</B></FONT></TD>
    <TD STYLE="padding-right: 4pt; width: 21%; border-top: Black 2.25pt solid; border-bottom: Black 1pt solid; text-align: center; padding-left: 4pt"><FONT STYLE="font-size: 10pt"><B>Amount of Registration Fee (4)</B></FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="border-right: Black 1pt solid; border-bottom: Black 1pt solid"><FONT STYLE="font-size: 10pt">Ordinary Shares, par value of $0.20 per Ordinary Share (&ldquo;Ordinary Shares&rdquo;) (1)</FONT></TD>
    <TD STYLE="border-right: Black 1pt solid; border-bottom: Black 1pt solid; text-align: center"><FONT STYLE="background-color: white">5,000,000</FONT></TD>
    <TD STYLE="border-right: Black 1pt solid; border-bottom: Black 1pt solid; text-align: center">$20.41</TD>
    <TD STYLE="border-right: Black 1pt solid; border-bottom: Black 1pt solid; text-align: center">$102,050,000.00</TD>
    <TD STYLE="border-bottom: Black 1pt solid; text-align: center">$13,246.09</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="border-right: Black 1pt solid; border-bottom: Black 1pt solid"><FONT STYLE="font-size: 10pt">American Depositary Shares, each representing two Ordinary Shares (&ldquo;ADSs&rdquo;) (1)</FONT></TD>
    <TD STYLE="border-right: Black 1pt solid; border-bottom: Black 1pt solid; text-align: center"><FONT STYLE="background-color: white">2,500,000</FONT></TD>
    <TD STYLE="border-right: Black 1pt solid; border-bottom: Black 1pt solid; text-align: center">-</TD>
    <TD STYLE="border-right: Black 1pt solid; border-bottom: Black 1pt solid; text-align: center">-</TD>
    <TD STYLE="border-bottom: Black 1pt solid; text-align: center">-</TD></TR>
</TABLE>
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<TD STYLE="width: 0"></TD><TD STYLE="width: 0.5in">(1)</TD><TD STYLE="text-align: justify">ADSs, evidenced by American Depositary Receipts (&ldquo;ADRs&rdquo;) issuable upon deposit of Ordinary
Shares of Smith &amp; Nephew plc (the &ldquo;Company&rdquo; or the &ldquo;Registrant&rdquo;), have been registered pursuant to
a Registration Statement on Form F-6 filed with the Securities and Exchange Commission (the &ldquo;Commission&rdquo;) on September
23, 2019. Each ADS represents two Ordinary Shares.</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

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<TD STYLE="width: 0"></TD><TD STYLE="width: 0.5in">(2)</TD><TD STYLE="text-align: justify">Pursuant to Rule 416(a) under the Securities Act of 1933, as amended (&ldquo;Securities Act&rdquo;),
this Registration Statement shall also cover any additional shares of the Registrant&rsquo;s Ordinary Shares that become issuable
in respect of the securities identified in the above table by reason of any share dividend, share split, recapitalization or other
similar transaction effected without the Registrant&rsquo;s receipt of consideration that results in an increase in the number
of the outstanding shares of the Registrant&rsquo;s Ordinary Shares.</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

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<TD STYLE="width: 0"></TD><TD STYLE="width: 0.5in">(3)</TD><TD STYLE="text-align: justify">Estimated in accordance with Rules 457(c) and (h)&nbsp;of the Securities Act solely for the purpose
of calculating the registration fee based on the average of the high and low prices for an ADR reported on the New York Stock Exchange
on August 18, 2020, which average was $40.81 and, therefore represents $20.41 per Ordinary Share.</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

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<TD STYLE="width: 0"></TD><TD STYLE="width: 0.5in">(4)</TD><TD STYLE="text-align: justify">Rounded up to the nearest cent.</TD></TR></TABLE>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt">&nbsp;</P>








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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>INTRODUCTORY STATEMENT</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in"><FONT STYLE="background-color: white">This
Registration Statement on Form S-8 (the &ldquo;Registration Statement&rdquo;) is prepared to register the issuance of a maximum
number of 5,000,000 Ordinary Shares represented by 2,500,000 American Depository Shares of Smith &amp; Nephew plc, a public limited
company incorporated under the laws of England and Wales (the &ldquo;Registrant&rdquo;) that are reserved for issuance upon exercise
of options or settlement of awards under the Smith &amp; Nephew Global Share Plan 2020 (the &ldquo;Plan&rdquo;).</FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>Part I</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.5in">&#9;<FONT STYLE="background-color: white">The
information specified in Item 1 and Item 2 of Part I of Form S-8 is omitted from this filing in accordance with the provisions
of Rule&nbsp;</FONT>428<FONT STYLE="background-color: white">&nbsp;under the&nbsp;</FONT>Securities Act<FONT STYLE="background-color: white">&nbsp;and
the introductory note to Part I of the Form S-8 instructions. The documents containing the information specified in Part I have
been delivered to the participants in the Plan as required by Rule 428(b)(1).</FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.5in">&nbsp;</P>


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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>PART II</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>Information Required in the Registration
Statement</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B>Item 3. <U>Incorporation of Documents by Reference</U>.</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.5in">The following documents
filed by the Registrant with the Commission pursuant to the Securities Act of 1933, as amended (the &ldquo;<B>Securities Act</B>&rdquo;),
and the Securities Exchange Act of 1934, as amended (the &ldquo;<B>Exchange Act</B>&rdquo;), are incorporated herein by reference:</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.5in">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 32.05pt"></TD><TD STYLE="width: 16.95pt">(a)</TD><TD STYLE="text-align: justify; padding-right: 29pt">the Registrant&rsquo;s Annual Report on Form 20-F for the fiscal year ended
December 31, 2019, filed with the Commission on March 2, 2020;</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 32.05pt"></TD><TD STYLE="width: 16.95pt">(b)</TD><TD STYLE="text-align: justify; padding-right: 29pt">all other reports filed pursuant to Section 13(a) or 15(d) of the Exchange
Act since the end of the fiscal year covered by the Registrant's Annual Report referred to in (a) above; and</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 32.05pt"></TD><TD STYLE="width: 16.95pt">(c)</TD><TD STYLE="text-align: justify; padding-right: 29pt">the description of the Registrant&rsquo;s Ordinary Shares and ADRs evidencing
ADSs contained in the Registrant&rsquo;s Registration Statement on Form F-6 (Registration No. 333-233881) filed with the Commission
on September 23, 2019, including any amendments or reports filed for the purpose of updating such description.</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.5in">All other documents
filed by the Registrant pursuant to Section&nbsp;13(a), 13(c), 14 or 15(d) of the Exchange Act subsequent to the filing of this
Registration Statement and prior to the filing of a post-effective amendment which indicates that all securities offered hereby
have been sold or which deregisters all securities then remaining unsold and, to the extent designated therein, reports furnished
to the Commission on Form 6-K, shall be deemed to be incorporated by reference into this Registration Statement and to be a part
hereof from the date of filing or furnishing of such documents, except as to specific sections of such documents as set forth therein.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.5in">Any statement contained
in a document incorporated or deemed to be incorporated by reference herein shall be deemed to be modified or superseded for purposes
of this Registration Statement to the extent that a statement contained in any subsequently filed document that also is deemed
to be incorporated by reference herein modifies or supersedes such statement. Any such statement so modified or superseded shall
not be deemed, except as so modified or superseded, to constitute a part of this Registration Statement.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B>Item 4. <U>Description of Securities</U>.</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Not applicable</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B>Item 5. <U>Interests of Named Experts and Counsel</U>.</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">Not applicable.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><B>Item 6. <U>Indemnification of Directors
and Officers</U>.</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in; background-color: white">English law does
not permit a company to indemnify a director or an officer of the company against any liability which by virtue of any rule of
law would otherwise attach to him in respect of negligence, default, breach of duty or breach of trust in relation to the company
except liability incurred by such director or officer in defending any legal proceeding (whether civil or criminal) in which judgment
is given in his favor or in which he is acquitted or in certain instances where, although he is liable, a court finds such director
or officer acted honestly and reasonably and that having regard to all the circumstances he ought fairly to be excused and relief
is granted by the court. These restrictions do not prevent a company from purchasing and maintaining insurance against any such
liability for any such director or officer.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in; background-color: white">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in; background-color: white">Article 146 of
the Registrant&rsquo;s Articles of Association provides:</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in; background-color: white">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in; background-color: white">&ldquo;Subject
to the provisions of the Statutes (but so that this Article does not extend to any matter insofar as it would cause this Article
or any part of it to be void under the Statutes) but without prejudice to any indemnity to which the person concerned may otherwise
be entitled, every person who is or was at any time a director of the Company or any Group Company (as defined in Article 89.2)
may be indemnified out of the assets of the Company against all costs, charges, expenses, losses or liabilities (together&nbsp;&quot;Liabilities&quot;)
which he or she may sustain or incur in or about the actual or purported execution and/or discharge of his or her duties (including
those duties, powers and discretions in relation to any Group Company or any company that is a trustee of an occupational pension
scheme (as defined in section 235(6) of the 2006 Act)) and/or the actual or purported exercise of his or her powers or discretions
and/or otherwise in relation thereto or in connection therewith, including (without prejudice to the generality of the foregoing)
any Liability suffered or incurred by him or her in disputing, defending, investigating or providing evidence in connection with
any actual or threatened or alleged claims, demands, investigations, or proceedings, whether civil, criminal, or regulatory or
in connection with any application under section 661(3) or (4) or section 1157 of the 2006 Act.&rdquo;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in; background-color: white">&nbsp;</P>


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    <DIV STYLE="page-break-before: always; margin-top: 6pt; margin-bottom: 6pt"><P STYLE="margin: 0pt"></P></DIV>
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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in; background-color: white">The Registrant
maintains an insurance policy for its directors and officers in respect of liabilities arising out of any act, error or omission
while acting in their capacities as directors or officers of the Registrant or its affiliated companies.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in; background-color: white">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in; background-color: white">The Registrant
has entered into separate deeds of indemnity with each of its current directors and officers to indemnify the director or officer,
as applicable, as specified in the applicable deed of indemnity, which may provide for indemnification up to the full extent permitted
by English law, and will enter into a separate indemnity agreement with any new director or officer.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in; background-color: white">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><B>Item 7. <U>Exemption from Registration
Claimed</U>.</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">Not applicable.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><B>Item 8. <U>Exhibits</U>.</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
<TR>
    <TD><B>Exhibit</B></TD>
    <TD STYLE="padding-right: 4pt"><FONT STYLE="color: Black">&nbsp;</FONT></TD>
    <TD COLSPAN="4"><B><U>Incorporated by Reference</U></B></TD>
    <TD><B>Filed</B></TD></TR>
<TR>
    <TD STYLE="width: 8%"><B><U>Number</U></B></TD>
    <TD STYLE="padding-right: 4pt; width: 48%"><FONT STYLE="color: Black"><B><U>Exhibit Description</U></B></FONT></TD>
    <TD STYLE="width: 5%"><B><U>Form</U></B></TD>
    <TD STYLE="width: 10%"><B><U>File No.</U></B></TD>
    <TD STYLE="width: 7%"><B><U>Exhibit</U></B></TD>
    <TD STYLE="width: 14%"><B><U>Filing Date</U></B></TD>
    <TD STYLE="width: 8%"><B><U>Herewith</U></B></TD></TR>
<TR>
    <TD>&nbsp;</TD>
    <TD STYLE="padding-right: 4pt"><FONT STYLE="color: Black">&nbsp;</FONT></TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR>
    <TD>4.1</TD>
    <TD STYLE="padding-right: 4pt"><FONT STYLE="color: Black"><U STYLE="text-decoration: none"><A HREF="http://www.sec.gov/Archives/edgar/data/845982/000155837020001838/snn-20191231ex138f000fd.htm">The Registrant&rsquo;s Articles of Association.</A></U></FONT></TD>
    <TD>20-F</TD>
    <TD>&nbsp;</TD>
    <TD>1</TD>
    <TD>March 2, 2020</TD>
    <TD>&nbsp;</TD></TR>
<TR>
    <TD>&nbsp;</TD>
    <TD STYLE="padding-right: 4pt">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR>
    <TD>4.3</TD>
    <TD STYLE="padding-right: 4pt"><FONT STYLE="color: Black"><U STYLE="text-decoration: none"><A HREF="http://www.sec.gov/Archives/edgar/data/845982/000119380519000840/e618664_ex99-a.htm">Form of Fifth Amended and Restated Deposit Agreement, dated as of &nbsp;&nbsp;, 2019, among the Company, JPMorgan Chase Bank, N.A. as depositary, and holders and beneficial owners of ADRs issued thereunder.</A></U></FONT></TD>
    <TD>F-6</TD>
    <TD>&nbsp;</TD>
    <TD>99(A)</TD>
    <TD>September 23, 2019</TD>
    <TD>&nbsp;</TD></TR>
<TR>
    <TD>&nbsp;</TD>
    <TD STYLE="padding-right: 4pt">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR>
    <TD>5.1</TD>
    <TD STYLE="padding-right: 4pt"><FONT STYLE="color: Black"><U STYLE="text-decoration: none"><A HREF="dp134756_ex0501.htm" STYLE="color: Blue">Opinion of Slaughter and May.</A></U></FONT></TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>X</TD></TR>
<TR>
    <TD>&nbsp;</TD>
    <TD STYLE="padding-right: 4pt">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR>
    <TD>23.1</TD>
    <TD STYLE="padding-right: 4pt"><FONT STYLE="color: Black"><U STYLE="text-decoration: none"><A HREF="dp134756_ex2301.htm">Consent of KPMG LLP, Independent Registered Public Accounting Firm of Registrant.</A></U></FONT></TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>X</TD></TR>
<TR>
    <TD>&nbsp;</TD>
    <TD STYLE="padding-right: 4pt">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR>
    <TD>23.2</TD>
    <TD STYLE="padding-right: 4pt"><FONT STYLE="color: Black"><U STYLE="text-decoration: none"><A HREF="dp134756_ex0501.htm" STYLE="color: Blue">Consent of Slaughter and May (included in Exhibit 5.1).</A></U></FONT></TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>X</TD></TR>
<TR>
    <TD>&nbsp;</TD>
    <TD STYLE="padding-right: 4pt">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR>
    <TD>24</TD>
    <TD STYLE="padding-right: 4pt"><FONT STYLE="color: Black"><U STYLE="text-decoration: none"><A HREF="#poa">Power of Attorney (included on the signature page of this Registration Statement).</A></U></FONT></TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>X</TD></TR>
<TR>
    <TD>&nbsp;</TD>
    <TD STYLE="padding-right: 4pt">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR>
    <TD>99.1</TD>
    <TD STYLE="padding-right: 4pt"><FONT STYLE="color: Black"><U STYLE="text-decoration: none"><A HREF="dp134756_ex9901.htm">The Smith &amp; Nephew Global Share Plan 2020.</A></U></FONT></TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>X</TD></TR>
</TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><B>Item 9. <U>Undertakings</U>.</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; background-color: white">(a) The undersigned&nbsp;Registrant&nbsp;hereby
undertakes:</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; background-color: white">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 12pt; background-color: white">(1)&nbsp;To file, during any
period in which offers or sales are being made, a post-effective amendment to this Registration Statement:</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 12pt; background-color: white">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 24pt; background-color: white">(i)&nbsp;To include any prospectus
required by Section 10(a)(3) of the&nbsp;Securities
Act of 1933;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 24pt; background-color: white">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 24pt; background-color: white">(ii)&nbsp;To reflect in the
prospectus any facts or events arising after the effective date of this Registration Statement (or the most recent post-effective
amendment thereof) which, individually or in the aggregate, represent a fundamental change in the information set forth in this
Registration Statement. Notwithstanding the foregoing, any increase or decrease in volume of securities offered (if the total dollar
value of securities offered would not exceed that which was registered) and any deviation from the low or high end of the estimated
maximum offering range may be reflected in the form of prospectus filed with the Commission pursuant to Rule 424(b) (&sect;
230.424(b)&nbsp;of this chapter) if, in the aggregate, the changes in volume and price represent no more than 20% change in
the maximum&nbsp;aggregate
offering price&nbsp;set forth in the &ldquo;Calculation of Registration Fee&rdquo; table in the effective registration statement.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 24pt; background-color: white">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 24pt; background-color: white">(iii)&nbsp;To include any&nbsp;material&nbsp;information
with respect to the&nbsp;plan&nbsp;of&nbsp;distribution&nbsp;not
previously disclosed in this Registration Statement or any&nbsp;material&nbsp;change
to such information in this Registration Statement;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 24pt; background-color: white">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 24pt; background-color: white"><I>Provided, however,</I>&nbsp;that
paragraphs (a)(1)(i) and (a)(1)(ii) do not apply if the registration statement is on Form S-8, and the information required to
be included in a post-effective amendment by those paragraphs is contained in reports filed with or furnished to the Commission
by the&nbsp;Registrant&nbsp;pursuant
to Section 13 or Section 15(d) of the&nbsp;Securities
Exchange Act of 1934 that are incorporated by reference in this Registration Statement.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 24pt; background-color: white">&nbsp;</P>


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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 12pt; background-color: white">(2)&nbsp;That, for the purpose
of determining any liability under the&nbsp;Securities
Act of 1933, each such post-effective amendment shall be deemed to be a new registration statement relating to the securities
offered therein, and the offering of such securities at that time shall be deemed to be the initial bona fide offering thereof.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 12pt; background-color: white">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 12pt; background-color: white">(3)&nbsp;To remove from registration
by means of a post-effective amendment any of the securities being registered which remain unsold at the termination of the offering.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 12pt; background-color: white">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; background-color: white">(b) The undersigned Registrant hereby
undertakes that, for purposes of determining any liability under the&nbsp;Securities
Act of 1933, each filing of the Registrant's annual report pursuant to Section 13(a) or Section 15(d) of the&nbsp;Securities
Exchange Act of 1934&nbsp;(and, where applicable, each filing of an employee benefit plan's annual report pursuant to section
15(d) of the&nbsp;Securities Exchange Act of 1934)
that is incorporated by reference in this Registration Statement shall be deemed to be a new registration statement relating to
the securities offered therein, and the offering of such securities at that time shall be deemed to be the initial bona fide offering
thereof.&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; background-color: white">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; background-color: white">(c) Insofar as indemnification for
liabilities arising under the&nbsp;Securities
Act of 1933&nbsp;may be permitted to directors, officers and controlling persons of the Registrant pursuant to the foregoing
provisions, or otherwise, the registrant has been advised that in the opinion of the&nbsp;Securities and Exchange Commission&nbsp;such
indemnification is against public policy as expressed in the Securities Act and is, therefore, unenforceable. In the event that
a claim for indemnification against such liabilities (other than the payment by the Registrant of expenses incurred or paid by
a director, officer or controlling person of the Registrant in the successful defense of any action, suit or proceeding) is asserted
by such director, officer or controlling person in connection with the securities being registered, the Registrant will, unless
in the opinion of its counsel the matter has been settled by controlling precedent, submit to a court of appropriate jurisdiction
the question whether such indemnification by it is against public policy as expressed in the Securities Act and will be governed
by the final adjudication of such issue.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; background-color: white">&nbsp;</P>


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    <DIV STYLE="page-break-before: always; margin-top: 6pt; margin-bottom: 6pt"><P STYLE="margin: 0pt"></P></DIV>
    <!-- Field: /Page -->

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>SIGNATURES</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.5in">Pursuant to the requirements
of the Securities Act of 1933, as amended the Registrant certifies that it has reasonable grounds to believe that it meets all
of the requirements for filing on Form S-8 and has duly caused this Registration Statement to be signed on its behalf by the undersigned,
thereunto duly authorized, in the City of London, United Kingdom on the 21<SUP>st</SUP> day of August, 2020.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.5in">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
<TR>
    <TD STYLE="vertical-align: bottom; width: 55%">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; width: 25%"><B>SMITH &amp; NEPHEW plc</B></TD>
    <TD STYLE="vertical-align: top; width: 20%">&nbsp;</TD></TR>
<TR>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: top">&nbsp;</TD></TR>
<TR>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: top">&nbsp;</TD></TR>
<TR>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; border-bottom: Black 1pt solid; text-align: justify">/s/ Susan Swabey</TD>
    <TD STYLE="vertical-align: top; text-align: justify">&nbsp;</TD></TR>
<TR>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom"><FONT STYLE="font-size: 10pt"><B>Susan Swabey</B></FONT></TD>
    <TD STYLE="vertical-align: top">&nbsp;</TD></TR>
<TR>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom"><FONT STYLE="font-size: 10pt"><B>Company Secretary</B></FONT></TD>
    <TD STYLE="vertical-align: top">&nbsp;</TD></TR>
</TABLE>

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    <DIV STYLE="page-break-before: always; margin-top: 6pt; margin-bottom: 6pt"><P STYLE="margin: 0pt"></P></DIV>
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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 141pt; text-align: center; text-indent: -141pt"><A NAME="poa"></A><B>POWER
OF ATTORNEY</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 141pt; text-align: center; text-indent: -141pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.5in"><B>KNOW ALL PERSONS
BY THESE PRESENTS</B>, that the undersigned officers and directors of Registrant do hereby constitute and appoint Susan Swabey,
Company Secretary, and Anne-Francoise Nesmes, Chief Financial Officer, and each of them, the lawful attorneys-in-fact and agents
with full power and authority to do any and all acts and things and to execute any and all instruments which said attorneys and
agents, and any one of them, determine may be necessary or advisable or required to enable said corporation to comply with the
Securities Act of 1933, as amended, and any rules or regulations or requirements of the Securities and Exchange Commission in connection
with this Registration Statement. Without limiting the generality of the foregoing power and authority, the powers granted include
the power and authority to sign the names of the undersigned officers and directors in the capacities indicated below to this Registration
Statement, to any and all amendments, both pre-effective and post-effective, and supplements to this Registration Statement, and
to any and all instruments or documents filed as part of or in conjunction with this Registration Statement or amendments or supplements
thereof, and each of the undersigned hereby ratifies and confirms that all said attorneys and agents, or any one of them, shall
do or cause to be done by virtue hereof.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.5in"><B>IN WITNESS WHEREOF</B>,
each of the undersigned has executed this Power of Attorney as of the date indicated.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">Pursuant to the requirements of the Securities
Act of 1933, as amended, this Registration Statement has been signed by the following persons on behalf of the Registrant in the
capacities and on the dates indicated.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&nbsp;</P>


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<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
<TR>
    <TD STYLE="width: 40%; border-bottom: Black 1pt solid; text-align: center"><B>Signature</B></TD>
    <TD STYLE="width: 2%">&nbsp;</TD>
    <TD STYLE="width: 33%; border-bottom: Black 1pt solid; text-align: center"><B>Title</B></TD>
    <TD STYLE="width: 2%">&nbsp;</TD>
    <TD STYLE="width: 23%; border-bottom: Black 1pt solid; text-align: center"><B>Date</B></TD></TR>
<TR>
    <TD STYLE="text-align: center">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD STYLE="text-align: center">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD STYLE="text-align: center">&nbsp;</TD></TR>
<TR>
    <TD STYLE="vertical-align: bottom; border-bottom: Black 1pt solid; text-align: center">/s/ Roberto Quarta</TD>
    <TD>&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; text-align: center">Chairman</TD>
    <TD>&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; text-align: center">August 21, 2020</TD></TR>
<TR>
    <TD STYLE="text-align: center"><B>Roberto Quarta</B></TD>
    <TD>&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; text-align: center">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR>
    <TD STYLE="text-align: center">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; text-align: center">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR>
    <TD STYLE="vertical-align: bottom; border-bottom: Black 1pt solid; text-align: center">/s/ Roland Diggelmann</TD>
    <TD>&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; text-align: center">Chief Executive Officer</TD>
    <TD>&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; text-align: center">August 21, 2020</TD></TR>
<TR>
    <TD STYLE="text-align: center"><B>Roland Diggelmann</B></TD>
    <TD>&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; text-align: center">(<I>Principal Executive Officer</I>)</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR>
    <TD STYLE="text-align: center">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; text-align: center">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR>
    <TD STYLE="vertical-align: bottom; border-bottom: Black 1pt solid; text-align: center">/s/ Anne-Francoise Nesmes</TD>
    <TD>&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; text-align: center">Chief Financial Officer</TD>
    <TD>&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; text-align: center">August 21, 2020</TD></TR>
<TR>
    <TD STYLE="text-align: center"><B>Anne-Francoise Nesmes</B></TD>
    <TD>&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; text-align: center">(<I>Principal Financial and Accounting Officer</I>)</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR>
    <TD STYLE="text-align: center">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; text-align: center">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR>
    <TD STYLE="vertical-align: bottom; border-bottom: Black 1pt solid; text-align: center">/s/ Vinita Bali</TD>
    <TD>&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; text-align: center">Non-Executive Director</TD>
    <TD>&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; text-align: center">August 21, 2020</TD></TR>
<TR>
    <TD STYLE="text-align: center"><B>Vinita Bali</B></TD>
    <TD>&nbsp;</TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR>
    <TD STYLE="text-align: center">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR>
    <TD STYLE="vertical-align: bottom; border-bottom: Black 1pt solid; text-align: center">/s/ Baroness Virginia Bottomley</TD>
    <TD>&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; text-align: center">Non-Executive Director</TD>
    <TD>&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; text-align: center">August 21, 2020</TD></TR>
<TR>
    <TD STYLE="text-align: center"><B>Baroness Virginia Bottomley</B></TD>
    <TD>&nbsp;</TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR>
    <TD STYLE="text-align: center">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR>
    <TD STYLE="vertical-align: bottom; border-bottom: Black 1pt solid; text-align: center">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; text-align: center">Non-Executive Director</TD>
    <TD>&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; text-align: center">&nbsp;</TD></TR>
<TR>
    <TD STYLE="text-align: center"><B>Erik Engstrom</B></TD>
    <TD>&nbsp;</TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR>
    <TD STYLE="text-align: center">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR>
    <TD STYLE="vertical-align: bottom; border-bottom: Black 1pt solid; text-align: center">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; text-align: center">Non-Executive Director</TD>
    <TD>&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; text-align: center">&nbsp;</TD></TR>
<TR>
    <TD STYLE="vertical-align: top; text-align: center"><B>Rick Medlock</B></TD>
    <TD>&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; text-align: center">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; text-align: center">&nbsp;</TD></TR>
<TR>
    <TD STYLE="vertical-align: top; text-align: center">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; text-align: center">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; text-align: center">&nbsp;</TD></TR>
<TR>
    <TD STYLE="vertical-align: bottom; border-bottom: Black 1pt solid; text-align: center">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; text-align: center">Non-Executive Director</TD>
    <TD>&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; text-align: center">&nbsp;</TD></TR>
<TR>
    <TD STYLE="text-align: center"><B>Robin Freestone</B></TD>
    <TD>&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; text-align: center">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR>
    <TD STYLE="text-align: center">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; text-align: center">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR>
    <TD STYLE="vertical-align: bottom; border-bottom: Black 1pt solid; text-align: center">/s/ Marc Owen</TD>
    <TD>&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; text-align: center">Non-Executive Director</TD>
    <TD>&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; text-align: center">August 21, 2020</TD></TR>
<TR>
    <TD STYLE="text-align: center"><B>Marc Owen</B></TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR>
    <TD STYLE="text-align: center">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR>
    <TD STYLE="vertical-align: bottom; border-bottom: Black 1pt solid; text-align: center">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; text-align: center">Non-Executive Director</TD>
    <TD>&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; text-align: center">&nbsp;</TD></TR>
<TR>
    <TD STYLE="text-align: center"><B>Angie Risley</B></TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR>
    <TD STYLE="text-align: center">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR>
    <TD STYLE="vertical-align: bottom; border-bottom: Black 1pt solid; text-align: center">/s/ Bob White</TD>
    <TD>&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; text-align: center">Non-Executive Director</TD>
    <TD>&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; text-align: center">August 21, 2020</TD></TR>
<TR>
    <TD STYLE="text-align: center"><B>Bob White</B></TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
</TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B>&nbsp;</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B>AUTHORIZED U.S. REPRESENTATIVE</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 35%; border-collapse: collapse">
<TR STYLE="vertical-align: bottom">
    <TD STYLE="width: 100%; border-bottom: Black 1pt solid; text-align: center">/s/ Catheryn O&rsquo;Rourke</TD></TR>
<TR>
    <TD STYLE="text-align: center"><B>Smith &amp; Nephew plc</B></TD></TR>
</TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">By: Catheryn O&rsquo;Rourke, as duly authorized representative
of Smith &amp; Nephew plc in the United States</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Date: August 21, 2020</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"></P>

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[{"type": "S-8", "sequence": "1", "filename": "dp134756_s8.htm", "description": "FORM S-8", "secsgml_size_bytes": 60049}]
{"company-data": {"conformed-name": "SMITH & NEPHEW PLC", "cik": "0000845982", "assigned-sic": "3842", "irs-number": "000000000", "fiscal-year-end": "1231"}, "filing-values": {"form-type": "S-8", "act": "33", "file-number": "333-248215", "film-number": "201121672"}, "business-address": {"street1": "BUILDING 5, CROXLEY PARK", "street2": "HATTERS LANE", "city": "WATFORD, HERTFORDSHIRE", "state": "X0", "zip": "WD18 8YE", "phone": "44 (0) 1923 477 100"}, "mail-address": {"street1": "BUILDING 5, CROXLEY PARK", "street2": "HATTERS LANE", "city": "WATFORD, HERTFORDSHIRE", "state": "X0", "zip": "WD18 8YE"}}
As filed with the Securities and Exchange
Commission on August 21, 2020
Registration No. 333-
UNITED STATES
SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
_____________________
FORM S-8
REGISTRATION STATEMENT UNDER THE SECURITIES
ACT OF 1933
______________________
SMITH & NEPHEW plc
(Exact Name of Registrant as Specified in
Its Charter)
England & Wales
None
(State or Other Jurisdiction
of Incorporation or Organization)
(I.R.S. Employer
Identification No.)
Building 5, Croxley Park, Hatters Lane,
Watford, Hertfordshire WD18 8YE, England
(Address of Principal Executive Offices)
The Smith & Nephew Global Share Plan
2020
(Full Title of the Plans)
______________________
Smith & Nephew, Inc.
150 Minuteman Road
Andover, MA 01810
(Name and Address of Agent For Service)
(978) 749-1000
(Telephone Number, including
area code, of agent for service)
______________________
Copies to:
John Meade, Esq.
Davis Polk & Wardwell LLP
450 Lexington Avenue
New York, New York 10017
(212) 450-4000
Kyoko Takahashi Lin, Esq.
Davis Polk & Wardwell LLP
450 Lexington Avenue
New York, New York 10017
(212) 450-4000
______________________
Indicate by check mark whether the Registrant is a large
accelerated filer, an accelerated filer, a non-accelerated filer, a smaller reporting company or an emerging growth company. See
definitions of "large accelerated filer," "accelerated filer," "smaller reporting company,"
and "emerging growth company" in Rule 12b-2 of the Exchange Act.
Large accelerated filer
x
Accelerated filer
¨
Non-accelerated filer
¨
Smaller reporting company
¨
Emerging growth company
¨
If an emerging growth company, indicate by check mark if the
registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards
provided pursuant to Section 7(a)(2)(B) of the Securities Act.
¨
CALCULATION OF REGISTRATION FEE
Title of Securities
To Be Registered
Amount To Be
Registered (2)
Proposed Maximum Offering Price
Per Share (3) (4)
Proposed Maximum Aggregate Offering Price (3) (4)
Amount of Registration Fee (4)
Ordinary Shares, par value of $0.20 per Ordinary Share ("Ordinary Shares") (1)
5,000,000
$20.41
$102,050,000.00
$13,246.09
American Depositary Shares, each representing two Ordinary Shares ("ADSs") (1)
2,500,000
-
-
-
(1)
ADSs, evidenced by American Depositary Receipts ("ADRs") issuable upon deposit of Ordinary
Shares of Smith & Nephew plc (the "Company" or the "Registrant"), have been registered pursuant to
a Registration Statement on Form F-6 filed with the Securities and Exchange Commission (the "Commission") on September
23, 2019. Each ADS represents two Ordinary Shares.
(2)
Pursuant to Rule 416(a) under the Securities Act of 1933, as amended ("Securities Act"),
this Registration Statement shall also cover any additional shares of the Registrant's Ordinary Shares that become issuable
in respect of the securities identified in the above table by reason of any share dividend, share split, recapitalization or other
similar transaction effected without the Registrant's receipt of consideration that results in an increase in the number
of the outstanding shares of the Registrant's Ordinary Shares.
(3)
Estimated in accordance with Rules 457(c) and (h) of the Securities Act solely for the purpose
of calculating the registration fee based on the average of the high and low prices for an ADR reported on the New York Stock Exchange
on August 18, 2020, which average was $40.81 and, therefore represents $20.41 per Ordinary Share.
(4)
Rounded up to the nearest cent.
INTRODUCTORY STATEMENT
This
Registration Statement on Form S-8 (the "Registration Statement") is prepared to register the issuance of a maximum
number of 5,000,000 Ordinary Shares represented by 2,500,000 American Depository Shares of Smith & Nephew plc, a public limited
company incorporated under the laws of England and Wales (the "Registrant") that are reserved for issuance upon exercise
of options or settlement of awards under the Smith & Nephew Global Share Plan 2020 (the "Plan").
Part I
The
information specified in Item 1 and Item 2 of Part I of Form S-8 is omitted from this filing in accordance with the provisions
of Rule
428
under the
Securities Act
and
the introductory note to Part I of the Form S-8 instructions. The documents containing the information specified in Part I have
been delivered to the participants in the Plan as required by Rule 428(b)(1).
PART II
Information Required in the Registration
Statement
Item 3.
Incorporation of Documents by Reference
.
The following documents
filed by the Registrant with the Commission pursuant to the Securities Act of 1933, as amended (the "
Securities Act
"),
and the Securities Exchange Act of 1934, as amended (the "
Exchange Act
"), are incorporated herein by reference:
(a)
the Registrant's Annual Report on Form 20-F for the fiscal year ended
December 31, 2019, filed with the Commission on March 2, 2020;
(b)
all other reports filed pursuant to Section 13(a) or 15(d) of the Exchange
Act since the end of the fiscal year covered by the Registrant's Annual Report referred to in (a) above; and
(c)
the description of the Registrant's Ordinary Shares and ADRs evidencing
ADSs contained in the Registrant's Registration Statement on Form F-6 (Registration No. 333-233881) filed with the Commission
on September 23, 2019, including any amendments or reports filed for the purpose of updating such description.
All other documents
filed by the Registrant pursuant to Section 13(a), 13(c), 14 or 15(d) of the Exchange Act subsequent to the filing of this
Registration Statement and prior to the filing of a post-effective amendment which indicates that all securities offered hereby
have been sold or which deregisters all securities then remaining unsold and, to the extent designated therein, reports furnished
to the Commission on Form 6-K, shall be deemed to be incorporated by reference into this Registration Statement and to be a part
hereof from the date of filing or furnishing of such documents, except as to specific sections of such documents as set forth therein.
Any statement contained
in a document incorporated or deemed to be incorporated by reference herein shall be deemed to be modified or superseded for purposes
of this Registration Statement to the extent that a statement contained in any subsequently filed document that also is deemed
to be incorporated by reference herein modifies or supersedes such statement. Any such statement so modified or superseded shall
not be deemed, except as so modified or superseded, to constitute a part of this Registration Statement.
Item 4.
Description of Securities
.
Not applicable
Item 5.
Interests of Named Experts and Counsel
.
Not applicable.
Item 6.
Indemnification of Directors
and Officers
.
English law does
not permit a company to indemnify a director or an officer of the company against any liability which by virtue of any rule of
law would otherwise attach to him in respect of negligence, default, breach of duty or breach of trust in relation to the company
except liability incurred by such director or officer in defending any legal proceeding (whether civil or criminal) in which judgment
is given in his favor or in which he is acquitted or in certain instances where, although he is liable, a court finds such director
or officer acted honestly and reasonably and that having regard to all the circumstances he ought fairly to be excused and relief
is granted by the court. These restrictions do not prevent a company from purchasing and maintaining insurance against any such
liability for any such director or officer.
Article 146 of
the Registrant's Articles of Association provides:
"Subject
to the provisions of the Statutes (but so that this Article does not extend to any matter insofar as it would cause this Article
or any part of it to be void under the Statutes) but without prejudice to any indemnity to which the person concerned may otherwise
be entitled, every person who is or was at any time a director of the Company or any Group Company (as defined in Article 89.2)
may be indemnified out of the assets of the Company against all costs, charges, expenses, losses or liabilities (together "Liabilities")
which he or she may sustain or incur in or about the actual or purported execution and/or discharge of his or her duties (including
those duties, powers and discretions in relation to any Group Company or any company that is a trustee of an occupational pension
scheme (as defined in section 235(6) of the 2006 Act)) and/or the actual or purported exercise of his or her powers or discretions
and/or otherwise in relation thereto or in connection therewith, including (without prejudice to the generality of the foregoing)
any Liability suffered or incurred by him or her in disputing, defending, investigating or providing evidence in connection with
any actual or threatened or alleged claims, demands, investigations, or proceedings, whether civil, criminal, or regulatory or
in connection with any application under section 661(3) or (4) or section 1157 of the 2006 Act."
The Registrant
maintains an insurance policy for its directors and officers in respect of liabilities arising out of any act, error or omission
while acting in their capacities as directors or officers of the Registrant or its affiliated companies.
The Registrant
has entered into separate deeds of indemnity with each of its current directors and officers to indemnify the director or officer,
as applicable, as specified in the applicable deed of indemnity, which may provide for indemnification up to the full extent permitted
by English law, and will enter into a separate indemnity agreement with any new director or officer.
Item 7.
Exemption from Registration
Claimed
.
Not applicable.
Item 8.
Exhibits
.
Exhibit
Incorporated by Reference
Filed
Number
Exhibit Description
Form
File No.
Exhibit
Filing Date
Herewith
4.1
The Registrant's Articles of Association.
20-F
1
March 2, 2020
4.3
Form of Fifth Amended and Restated Deposit Agreement, dated as of   , 2019, among the Company, JPMorgan Chase Bank, N.A. as depositary, and holders and beneficial owners of ADRs issued thereunder.
F-6
99(A)
September 23, 2019
5.1
Opinion of Slaughter and May.
X
23.1
Consent of KPMG LLP, Independent Registered Public Accounting Firm of Registrant.
X
23.2
Consent of Slaughter and May (included in Exhibit 5.1).
X
24
Power of Attorney (included on the signature page of this Registration Statement).
X
99.1
The Smith & Nephew Global Share Plan 2020.
X
Item 9.
Undertakings
.
(a) The undersigned Registrant hereby
undertakes:
(1) To file, during any
period in which offers or sales are being made, a post-effective amendment to this Registration Statement:
(i) To include any prospectus
required by Section 10(a)(3) of the Securities
Act of 1933;
(ii) To reflect in the
prospectus any facts or events arising after the effective date of this Registration Statement (or the most recent post-effective
amendment thereof) which, individually or in the aggregate, represent a fundamental change in the information set forth in this
Registration Statement. Notwithstanding the foregoing, any increase or decrease in volume of securities offered (if the total dollar
value of securities offered would not exceed that which was registered) and any deviation from the low or high end of the estimated
maximum offering range may be reflected in the form of prospectus filed with the Commission pursuant to Rule 424(b) (§
230.424(b) of this chapter) if, in the aggregate, the changes in volume and price represent no more than 20% change in
the maximum aggregate
offering price set forth in the "Calculation of Registration Fee" table in the effective registration statement.
(iii) To include any material information
with respect to the plan of distribution not
previously disclosed in this Registration Statement or any material change
to such information in this Registration Statement;
Provided, however,
that
paragraphs (a)(1)(i) and (a)(1)(ii) do not apply if the registration statement is on Form S-8, and the information required to
be included in a post-effective amendment by those paragraphs is contained in reports filed with or furnished to the Commission
by the Registrant pursuant
to Section 13 or Section 15(d) of the Securities
Exchange Act of 1934 that are incorporated by reference in this Registration Statement.
(2) That, for the purpose
of determining any liability under the Securities
Act of 1933, each such post-effective amendment shall be deemed to be a new registration statement relating to the securities
offered therein, and the offering of such securities at that time shall be deemed to be the initial bona fide offering thereof.
(3) To remove from registration
by means of a post-effective amendment any of the securities being registered which remain unsold at the termination of the offering.
(b) The undersigned Registrant hereby
undertakes that, for purposes of determining any liability under the Securities
Act of 1933, each filing of the Registrant's annual report pursuant to Section 13(a) or Section 15(d) of the Securities
Exchange Act of 1934 (and, where applicable, each filing of an employee benefit plan's annual report pursuant to section
15(d) of the Securities Exchange Act of 1934)
that is incorporated by reference in this Registration Statement shall be deemed to be a new registration statement relating to
the securities offered therein, and the offering of such securities at that time shall be deemed to be the initial bona fide offering
thereof.
(c) Insofar as indemnification for
liabilities arising under the Securities
Act of 1933 may be permitted to directors, officers and controlling persons of the Registrant pursuant to the foregoing
provisions, or otherwise, the registrant has been advised that in the opinion of the Securities and Exchange Commission such
indemnification is against public policy as expressed in the Securities Act and is, therefore, unenforceable. In the event that
a claim for indemnification against such liabilities (other than the payment by the Registrant of expenses incurred or paid by
a director, officer or controlling person of the Registrant in the successful defense of any action, suit or proceeding) is asserted
by such director, officer or controlling person in connection with the securities being registered, the Registrant will, unless
in the opinion of its counsel the matter has been settled by controlling precedent, submit to a court of appropriate jurisdiction
the question whether such indemnification by it is against public policy as expressed in the Securities Act and will be governed
by the final adjudication of such issue.
SIGNATURES
Pursuant to the requirements
of the Securities Act of 1933, as amended the Registrant certifies that it has reasonable grounds to believe that it meets all
of the requirements for filing on Form S-8 and has duly caused this Registration Statement to be signed on its behalf by the undersigned,
thereunto duly authorized, in the City of London, United Kingdom on the 21
st
day of August, 2020.
SMITH & NEPHEW plc
/s/ Susan Swabey
Susan Swabey
Company Secretary
POWER
OF ATTORNEY
KNOW ALL PERSONS
BY THESE PRESENTS
, that the undersigned officers and directors of Registrant do hereby constitute and appoint Susan Swabey,
Company Secretary, and Anne-Francoise Nesmes, Chief Financial Officer, and each of them, the lawful attorneys-in-fact and agents
with full power and authority to do any and all acts and things and to execute any and all instruments which said attorneys and
agents, and any one of them, determine may be necessary or advisable or required to enable said corporation to comply with the
Securities Act of 1933, as amended, and any rules or regulations or requirements of the Securities and Exchange Commission in connection
with this Registration Statement. Without limiting the generality of the foregoing power and authority, the powers granted include
the power and authority to sign the names of the undersigned officers and directors in the capacities indicated below to this Registration
Statement, to any and all amendments, both pre-effective and post-effective, and supplements to this Registration Statement, and
to any and all instruments or documents filed as part of or in conjunction with this Registration Statement or amendments or supplements
thereof, and each of the undersigned hereby ratifies and confirms that all said attorneys and agents, or any one of them, shall
do or cause to be done by virtue hereof.
IN WITNESS WHEREOF
,
each of the undersigned has executed this Power of Attorney as of the date indicated.
Pursuant to the requirements of the Securities
Act of 1933, as amended, this Registration Statement has been signed by the following persons on behalf of the Registrant in the
capacities and on the dates indicated.
Signature
Title
Date
/s/ Roberto Quarta
Chairman
August 21, 2020
Roberto Quarta
/s/ Roland Diggelmann
Chief Executive Officer
August 21, 2020
Roland Diggelmann
(
Principal Executive Officer
)
/s/ Anne-Francoise Nesmes
Chief Financial Officer
August 21, 2020
Anne-Francoise Nesmes
(
Principal Financial and Accounting Officer
)
/s/ Vinita Bali
Non-Executive Director
August 21, 2020
Vinita Bali
/s/ Baroness Virginia Bottomley
Non-Executive Director
August 21, 2020
Baroness Virginia Bottomley
Non-Executive Director
Erik Engstrom
Non-Executive Director
Rick Medlock
Non-Executive Director
Robin Freestone
/s/ Marc Owen
Non-Executive Director
August 21, 2020
Marc Owen
Non-Executive Director
Angie Risley
/s/ Bob White
Non-Executive Director
August 21, 2020
Bob White
AUTHORIZED U.S. REPRESENTATIVE
/s/ Catheryn O'Rourke
Smith & Nephew plc
By: Catheryn O'Rourke, as duly authorized representative
of Smith & Nephew plc in the United States
Date: August 21, 2020