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    <div style="text-align: right; font-family: 'Times New Roman', Times, serif; font-size: 10pt; font-weight: bold;">Registration No. 333-_________</div>
    <div style="text-align: right; font-family: 'Times New Roman', Times, serif; font-size: 10pt; font-weight: bold;"> <br>
    </div>
    <div style="text-align: center;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif; font-weight: bold;">As filed with the Securities and Exchange
          Commission on June 17, 2019</font></font></div>
    <div style="text-align: center;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif; font-weight: bold;"></font><font style="font-size: 10pt;
          font-family: 'Times New Roman', Times, serif; font-weight: bold;"></font></font></div>
    <div style="text-align: center;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif; font-weight: bold;"> <br>
        </font></font></div>
    <div style="text-align: center;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif; font-weight: bold;">UNITED STATES</font></font></div>
    <div style="text-align: center;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif; font-weight: bold;">SECURITIES AND EXCHANGE COMMISSION</font></font></div>
    <div style="text-align: center;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif; font-weight: bold;">Washington, D.C.&#160; 20549</font></font></div>
    <div style="text-align: center;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif; font-weight: bold;"></font>_________________________</font></div>
    <div style="text-align: center;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;"> <br>
      </font></div>
    <div style="text-align: center;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif; font-weight: bold;">FORM S-8</font></div>
    <div style="text-align: center;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif; font-weight: bold;">REGISTRATION STATEMENT</font></div>
    <div style="text-align: center;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif; font-weight: bold;">UNDER</font></div>
    <div style="text-align: center;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif; font-weight: bold;">THE SECURITIES ACT OF 1933</font></div>
    <div style="text-align: center;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif; font-weight: bold;"> <br>
      </font></div>
    <div style="text-align: center;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif; font-weight: bold;">Esquire Financial Holdings, Inc.</font></div>
    <div style="text-align: center;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">(Exact Name of Registrant as Specified in its Charter)</font></div>
    <div><br>
    </div>
    <table cellspacing="0" cellpadding="0" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%;" id="z63b27fe4a3c14d27a9bf20d21474e782">

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            <div style="text-align: center;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif; font-weight: bold;">Maryland</font></div>
          </td>
          <td style="width: 50%; vertical-align: top;">
            <div style="text-align: center;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif; font-weight: bold;">27-5107901</font></div>
          </td>
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          <td style="width: 50%; vertical-align: top;">
            <div style="text-align: center;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">(State or Other Jurisdiction of</font></div>
          </td>
          <td style="width: 50%; vertical-align: top;">
            <div style="text-align: center;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">(I.R.S. Employer Identification No.)</font></div>
          </td>
        </tr>
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          <td style="width: 50%; vertical-align: top;">
            <div style="text-align: center;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">Incorporation or Organization)</font></div>
          </td>
          <td style="width: 50%; vertical-align: top;">&#160;</td>
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    </table>
    <div><br>
    </div>
    <div style="text-align: center;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif; font-weight: bold;">100 Jericho Quadrangle, Suite 100Jericho, New
          York 11753</font></font></div>
    <div style="text-align: center;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">(Address of Principal Executive Offices)</font></div>
    <div style="text-align: center;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;"> <br>
      </font></div>
    <div style="text-align: center;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif; font-weight: bold;">Esquire Financial Holdings, Inc. 2019
          Incentive Plan</font><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;"></font></font></div>
    <div style="text-align: center;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">(Full Title of the Plans)</font></font></div>
    <div style="text-align: center;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;"></font></font></div>
    <div style="text-align: center;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;"><br>
        Copies to:</font></div>
    <table cellspacing="0" cellpadding="0" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%;" id="ze49985b34a94428796b8a25cb2cf4106">

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            <div style="text-align: center;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">Mr. Andrew C. Sagliocca</font></div>
          </td>
          <td style="width: 5.34%; vertical-align: top;">&#160;</td>
          <td style="width: 47.32%; vertical-align: top;">
            <div style="text-align: center;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">John J. Gorman, Esquire</font></div>
          </td>
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          <td style="width: 47.35%; vertical-align: top;">
            <div style="text-align: center;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">President and Chief Executive Officer</font></div>
          </td>
          <td style="width: 5.34%; vertical-align: top;">&#160;</td>
          <td style="width: 47.32%; vertical-align: top;">
            <div style="text-align: center;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">Gary A. Lax, Esquire</font></div>
          </td>
        </tr>
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          <td style="width: 47.35%; vertical-align: top;">
            <div style="text-align: center;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">Esquire Financial Holdings, Inc.</font></div>
          </td>
          <td style="width: 5.34%; vertical-align: top;">&#160;</td>
          <td style="width: 47.32%; vertical-align: top;">
            <div style="text-align: center;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">Luse Gorman, PC</font></div>
          </td>
        </tr>
        <tr>
          <td style="width: 47.35%; vertical-align: top;">
            <div style="text-align: center;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">100 Jericho Quadrangle, Suite 100</font></div>
          </td>
          <td style="width: 5.34%; vertical-align: top;">&#160;</td>
          <td style="width: 47.32%; vertical-align: top;">
            <div style="text-align: center;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">5335 Wisconsin Ave., N.W., Suite 780</font></div>
          </td>
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          <td style="width: 47.35%; vertical-align: top;">
            <div style="text-align: center;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">Jericho, New York 11753</font></div>
          </td>
          <td style="width: 5.34%; vertical-align: top;">&#160;</td>
          <td style="width: 47.32%; vertical-align: top;">
            <div style="text-align: center;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">Washington, DC 20015-2035</font></div>
          </td>
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          <td style="width: 47.35%; vertical-align: top;">
            <div style="text-align: center;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">(516) 535-2002</font></div>
          </td>
          <td style="width: 5.34%; vertical-align: top;">&#160;</td>
          <td style="width: 47.32%; vertical-align: top;">
            <div style="text-align: center;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">(202) 274-2000</font></div>
          </td>
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          <td style="width: 47.35%; vertical-align: top;">
            <div style="text-align: center;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">(Name, Address and Telephone</font></div>
          </td>
          <td style="width: 5.34%; vertical-align: top;">&#160;</td>
          <td style="width: 47.32%; vertical-align: top;">&#160;</td>
        </tr>
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          <td style="width: 47.35%; vertical-align: top;">
            <div style="text-align: center;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">Number of Agent for Service)</font></div>
          </td>
          <td style="width: 5.34%; vertical-align: top;">&#160;</td>
          <td style="width: 47.32%; vertical-align: top;">&#160;</td>
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    <div><br>
    </div>
    <div style="text-align: justify;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, smaller reporting
        company, or an emerging growth company. See the definitions of &#8220;large accelerated filer,&#8221; &#8220;accelerated filer,&#8221; &#8220;smaller reporting company&#8221; and &#8220;emerging growth company&#8221; in Rule 12b-2 of the Securities Exchange Act of 1934, as amended (the &#8220;Exchange
        Act&#8221;):</font></div>
    <div><br>
    </div>
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          <td style="width: 66.66%; vertical-align: top;">
            <div style="text-align: left;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">Large accelerated filer <font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">&#9744;</font></font></div>
          </td>
          <td style="width: 33.34%; vertical-align: top;">
            <div style="text-align: left;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">Accelerated filer <font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">&#9746;</font></font></div>
          </td>
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          <td style="width: 66.66%; vertical-align: top;">
            <div style="text-align: left;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">Non-accelerated filer <font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">&#9744;</font>&#160; (Do not check if a smaller
                reporting company)</font></div>
          </td>
          <td style="width: 33.34%; vertical-align: top;">
            <div style="text-align: left;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">Smaller reporting company <font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">&#9746;</font></font></div>
          </td>
        </tr>
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          <td style="width: 66.66%; vertical-align: top;">
            <div style="text-align: left;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">Emerging growth company <font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">&#9746;</font></font></div>
          </td>
          <td style="width: 33.34%; vertical-align: top;">&#160;</td>
        </tr>

    </table>
    <div><br>
    </div>
    <div style="text-align: justify;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying
        with any new or revised financial accounting standards provided pursuant to Section 7(a)(2)(B) of the Securities Act. <font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">&#9746;</font></font></div>
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    <div style="text-align: center;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif; font-weight: bold;">CALCULATION OF REGISTRATION FEE</font></div>
    <div><br>
    </div>
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            <div style="text-align: center;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">Title of</font></div>
            <div style="text-align: center;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">Securities</font></div>
            <div style="text-align: center;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">to be</font></div>
            <div style="text-align: center;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">Registered</font></div>
          </td>
          <td style="width: 18.28%; vertical-align: bottom; border-bottom: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0); border-top: 2px solid rgb(0, 0, 0);">
            <div style="text-align: center;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">Amount</font></div>
            <div style="text-align: center;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">to be</font></div>
            <div style="text-align: center;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">Registered</font></div>
          </td>
          <td style="width: 19.62%; vertical-align: bottom; border-bottom: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0); border-top: 2px solid rgb(0, 0, 0);">
            <div style="text-align: center;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">Proposed</font></div>
            <div style="text-align: center;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">Maximum</font></div>
            <div style="text-align: center;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">Offering Price</font></div>
            <div style="text-align: center;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">Per Share</font></div>
          </td>
          <td style="width: 21.44%; vertical-align: bottom; border-bottom: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0); border-top: 2px solid rgb(0, 0, 0);">
            <div style="text-align: center;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">Proposed</font></div>
            <div style="text-align: center;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">Maximum</font></div>
            <div style="text-align: center;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">Aggregate</font></div>
            <div style="text-align: center;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">Offering Price</font></div>
          </td>
          <td style="width: 18.54%; vertical-align: bottom; border-width: 2px; border-style: solid; border-color: rgb(0, 0, 0);">
            <div style="text-align: center;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">Amount of</font></div>
            <div style="text-align: center;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">Registration</font></div>
            <div style="text-align: center;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">Fee</font></div>
          </td>
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            <div style="text-align: left;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">Common stock, par value $0.01 per share</font></div>
          </td>
          <td style="width: 18.28%; vertical-align: bottom; border-left: 2px solid rgb(0, 0, 0); border-bottom: 2px solid rgb(0, 0, 0);">
            <div style="text-align: center;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">300,000<sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">(1)</sup></font></div>
          </td>
          <td style="width: 19.62%; vertical-align: bottom; border-left: 2px solid rgb(0, 0, 0); border-bottom: 2px solid rgb(0, 0, 0);">
            <div style="text-align: center;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">$24.70<sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">(2)</sup></font></div>
          </td>
          <td style="width: 21.44%; vertical-align: bottom; border-left: 2px solid rgb(0, 0, 0); border-bottom: 2px solid rgb(0, 0, 0);">
            <div style="text-align: center;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">$7,410,000</font></div>
          </td>
          <td style="width: 18.54%; vertical-align: bottom; border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0); border-bottom: 2px solid rgb(0, 0, 0);">
            <div style="text-align: center;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">$899</font></div>
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    <div style="text-align: left;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">_________________________</font></div>
    <div>
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              <div style="text-align: left;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">(1)</font></div>
            </td>
            <td style="width: auto; vertical-align: top;">
              <div style="text-align: justify;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">Together with an indeterminate number of additional shares that may be necessary to adjust the number of shares reserved for
                  issuance pursuant to the Esquire Financial Holdings, Inc. 2019 Equity Incentive Plan (the &#8220;2019 Equity Plan&#8221;) as a result of a stock split, stock dividend or similar adjustment of the outstanding common stock of Esquire Financial
                  Holdings, Inc. (the &#8220;Company&#8221;) pursuant to 17 C.F.R. Section&#160;230.416(a).</font></div>
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              <div style="text-align: left;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">(2)</font></div>
            </td>
            <td style="width: auto; vertical-align: top;">
              <div style="text-align: justify;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">Computed in accordance with Rule 457(h) under the Securities Act and based upon the high and low sales price of the Company&#8217;s
                  Common Stock as reported on the NASDAQ Capital Market on June 11, 2019.</font></div>
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    </div>
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    </div>
    <div style="text-align: center;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif; font-weight: bold;">_________________________</font></div>
    <div><br>
    </div>
    <div><br>
    </div>
    <div style="text-align: justify; text-indent: 36pt;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">This Registration Statement shall become effective upon filing in accordance with Section 8(a) of the Securities Act of
        1933 and 17 C.F.R. &#167; 230.462.</font></div>
    <div><br>
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    <div style="text-align: justify; margin-bottom: 12pt;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif; font-weight: bold;">PART I.</font></div>
    <div style="text-align: justify; margin-bottom: 12pt;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif; font-weight: bold;">Items 1 and 2.&#160; Plan Information and Registrant Information and Employee Plan Annual Information</font></div>
    <div style="text-align: justify; text-indent: 36pt; margin-bottom: 12pt;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">The documents containing the information specified in Part I of Form S-8 have been or will be sent or
        given to participants in the Stock Benefit Plans as specified by Rule 428(b)(1) promulgated by the Securities and Exchange Commission (the &#8220;Commission&#8221;) under the Securities Act of 1933, as amended (the &#8220;Securities Act&#8221;).</font></div>
    <div style="text-align: justify; text-indent: 36pt; margin-bottom: 12pt;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">Such documents are not being filed with the Commission, but constitute (along with the documents
        incorporated by reference into this Registration Statement pursuant to Item 3 of Part II hereof) a prospectus that meets the requirements of Section 10(a) of the Securities Act.</font></div>
    <div style="text-align: justify; margin-bottom: 12pt;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif; font-weight: bold;">PART II.</font></div>
    <div style="text-align: justify; margin-bottom: 12pt;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif; font-weight: bold;">Item 3.&#160; Incorporation of Documents by Reference</font></div>
    <div style="text-align: justify; text-indent: 36pt; margin-bottom: 12pt;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">The following documents previously or concurrently filed with the Commission are hereby incorporated
        by reference in this Registration Statement:</font></div>
    <div style="text-align: justify; text-indent: 36pt; margin-bottom: 12pt;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">(a)</font><font style="display: inline-block; text-indent: 0px; font-size: 1px; width: 36pt" id="TRGRRTFtoHTMLTab"> </font><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">The Company's Annual Report on Form 10-K for the year ended December 31, 2018 (File No. 001-38131) filed with the Commission on March 14,
        2019 pursuant to Section 13(a) of the Securities Exchange Act of 1934, as amended (the &#8220;Echange Act&#8221;); <br>
      </font></div>
    <div style="text-align: justify; text-indent: 36pt; margin-bottom: 12pt;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">(b)</font><font style="display: inline-block; text-indent: 0px; font-size: 1px; width: 36pt" id="TRGRRTFtoHTMLTab">&#160;</font><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">All other reports filed by the Company pursuant to Section 13(a) or 15(d) of the Exchange Act since the end of the year covered by the Annual
        Report on Form 10-K filed by the Company referred in (a) above; and</font></div>
    <div style="text-align: justify; text-indent: 36pt; margin-bottom: 12pt;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">(c)</font><font style="display: inline-block; text-indent: 0px; font-size: 1px; width: 36pt" id="TRGRRTFtoHTMLTab">&#160;</font><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">The description of the Company&#8217;s common stock contained in the
          Registration Statement on Form 8-A filed with the Commission on June 26, 2017 (File No. 001-38131).</font></font></div>
    <div style="text-align: justify; text-indent: 36pt; margin-bottom: 12pt;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">All documents subsequently filed by the Company with the Commission pursuant to Sections 13(a),
        13(c), 14, or 15(d) of the Securities Exchange Act of 1934, as amended, after the date hereof, and prior to the filing of a post-effective amendment which indicates that all securities offered hereby have been sold or which deregisters all
        securities then remaining unsold, shall be deemed incorporated by reference into this Registration Statement and to be a part thereof from the date of the filing of such documents.&#160; Any statement contained in the documents incorporated, or deemed
        to be incorporated, by reference herein or therein shall be deemed to be modified or superseded for purposes of this Registration Statement and the prospectus to the extent that a statement contained herein or therein or in any other subsequently
        filed document which also is, or is deemed to be, incorporated by reference herein or therein modifies or supersedes such statement.&#160; Any such statement so modified or superseded shall not be deemed, except as so modified or superseded, to
        constitute a part of this Registration Statement and the prospectus.</font></div>
    <div style="text-align: justify; text-indent: 36pt; margin-bottom: 12pt;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">All information appearing in this Registration Statement and the prospectus is qualified in its
        entirety by the detailed information, including financial statements, appearing in the documents incorporated herein or therein by reference.</font></div>
    <div style="text-align: justify; margin-bottom: 12pt;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif; font-weight: bold;">Item 4.&#160; Description of Securities</font></div>
    <div style="text-align: left; text-indent: 36pt;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">Not applicable.</font></div>
    <div><br>
    </div>
    <div style="text-align: justify; margin-bottom: 12pt;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif; font-weight: bold;">Item 5.&#160; Interests of Named Experts and Counsel</font></div>
    <div style="text-align: justify; text-indent: 36pt; margin-bottom: 12pt;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">None.</font></div>
    <div style="clear: both; margin-top: 10pt; margin-bottom: 10pt;" id="DSPFPageBreakArea">
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    <div style="text-align: justify; margin-bottom: 12pt;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif; font-weight: bold;">Item 6.&#160; Indemnification of Directors and Officers</font></div>
    <div style="text-align: left; text-indent: 36pt;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">Articles 10 and 11 of the Articles of Incorporation of Esquire Financial Holdings, Inc. (the &#8220;Corporation&#8221;) set forth
        circumstances under which directors, officers, employees and agents of the Corporation may be insured or indemnified against liability which they incur in their capacities as such:</font></div>
    <div style="text-align: left;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif; font-weight: bold;">&#160;</font></div>
    <div style="text-align: left;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif; font-weight: bold;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;"><u>ARTICLE 10. Indemnification, etc. of
            Directors and Officers.</u></font></font></div>
    <div style="text-align: left; text-indent: 36pt;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif; font-weight: bold;">&#160;</font></div>
    <div style="text-align: justify; text-indent: 36pt; margin-bottom: 12pt;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif; font-weight: bold;">A.</font><font style="display: inline-block; text-indent: 0px; font-size: 1px;
        width: 36pt" id="TRGRRTFtoHTMLTab">&#160;</font><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif; font-weight: bold;">Indemnification.&#160; </font>The
        Corporation shall indemnify (1) its current and former directors and officers, whether serving the Corporation or at its request any other entity, to the fullest extent required or permitted by the MGCL now or hereafter in force, including the
        advancement of expenses under the procedures and to the fullest extent permitted by law, and (2)&#160;other employees and agents to such extent as shall be authorized by the Board of Directors and permitted by law; provided, however, that, except as
        provided in Section&#160;B hereof with respect to proceedings to enforce rights to indemnification, the Corporation shall indemnify any such indemnitee in connection with a proceeding (or part thereof) initiated by such indemnitee only if such
        proceeding (or part thereof) was authorized by the Board of Directors of the Corporation.&#160; The right to indemnification conferred in Section A of this Article 10 shall included the right to be paid by the Corporation the expenses incurred in
        defending any such proceeding in advance of its final disposition (hereinafter an &#8220;advancement of expenses&#8221;); provided, however, that if the MGCL requires an advancement of expenses incurred by an indemnitee in his or her capacity as a director or
        officers (and not in any other capacity in which service was or is rendered by such indemnitee, including, without limitation, service to an employee benefit plan) shall be made only upon delivery to the Corporation of a written undertaking
        (hereinafter an &#8220;undertaking&#8221;), by or on behalf of such indemnitee, to repay all amounts so advanced if it shall ultimately be determined by a final judicial decision from which there is no further right to appeal that such indemnitee is not
        entitled to be indemnified for such expenses under Section A of this Article 10 or otherwise.</font></div>
    <div style="text-align: justify; text-indent: 36pt; margin-bottom: 12pt;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif; font-weight: bold;">B.</font><font style="display: inline-block; text-indent: 0px; font-size: 1px;
        width: 36pt" id="TRGRRTFtoHTMLTab">&#160;</font><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif; font-weight: bold;">Procedure.&#160; </font>If a claim
        under Section&#160;A of this Article&#160;10 is not paid in full by the Corporation within 60 days after a written claim has been received by the Corporation, except in the case of a claim for an advancement of expenses, in which case the applicable period
        shall be 20 days, the indemnitee may at any time thereafter bring suit against the Corporation to recover the unpaid amount of the claim.&#160; If successful in whole or in part in any such suit, or in a suit brought by the Corporation to recover an
        advancement of expenses pursuant to the terms of an undertaking, the indemnitee shall also be entitled to be reimbursed the expense of prosecuting or defending such suit.&#160; It shall be a defense to any action for advancement of expenses that the
        Corporation has not received both (i) an undertaking as required by law to repay such advances in the event it shall ultimately be determined that the standard of conduct has not been met and (ii)&#160;a written affirmation by the indemnitee of his good
        faith belief that the standard of conduct necessary for indemnification by the Corporation has been met.&#160; In (i) any suit brought by the indemnitee to enforce a right to indemnification hereunder (but not in a suit brought by the indemnitee to
        enforce a right to an advancement of expenses) it shall be a defense that, and (ii)&#160;any suit by the Corporation to recover an advancement of expenses pursuant to the terms of an undertaking the Corporation shall be entitled to recover such expenses
        upon a final adjudication that, the indemnitee has not met the applicable standard for indemnification set forth in the MGCL.&#160; Neither the failure of the Corporation (including its Board of Directors, independent legal counsel, or its stockholders)
        to have made a determination prior to the commencement of such suit that indemnification of the indemnitee is proper in the circumstances because the indemnitee has met the applicable standard of conduct set forth in the MGCL, nor an actual
        determination by the Corporation (including its Board of Directors, independent legal counsel, or its stockholders) that the indemnitee has not met such applicable standard of conduct, shall create a presumption that the indemnitee has not met the
        applicable standard of conduct or, in the case of such a suit brought by the indemnitee, be a defense to such suit.&#160; In any suit brought by the indemnitee to enforce a right to indemnification or to an advancement of expenses hereunder, or by the
        Corporation to recover an advancement of expenses pursuant to the terms of an undertaking, the burden of proving that the indemnitee is not entitled to be indemnified, or to such advancement of expenses, under this Article&#160;10 or otherwise shall be
        on the Corporation.</font></div>
    <div style="text-align: justify; text-indent: 36pt; margin-bottom: 12pt;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif; font-weight: bold;">C.</font><font style="display: inline-block; text-indent: 0px; font-size: 1px;
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        rights to indemnification and to the advancement of expenses conferred in this Article&#160;10 shall not be exclusive of any other right which any Person may have or hereafter acquire under any statute, these Articles, the Corporation&#8217;s Bylaws, any
        agreement, any vote of stockholders or the Board of Directors, or otherwise.</font></div>
    <div style="text-align: justify; text-indent: 36pt; margin-bottom: 12pt;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif; font-weight: bold;">D.</font><font style="display: inline-block; text-indent: 0px; font-size: 1px;
        width: 36pt" id="TRGRRTFtoHTMLTab">&#160;</font><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif; font-weight: bold;">Insurance.&#160; </font>The
        Corporation may maintain insurance, at its expense, to protect itself and any director, officer, employee or agent of the Corporation or another corporation, partnership, joint venture, trust or</font></div>
    <div id="DSPFPageBreakArea" style="clear: both; margin-top: 10pt; margin-bottom: 10pt;">
      <div id="DSPFPageBreak" style="page-break-after: always;">
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    <div style="text-align: justify; margin-bottom: 12pt;"><font style="font-size: 10pt; font-family: &quot;Times New Roman&quot;,Times,serif;">other enterprise against any expense, liability or loss, whether or not the Corporation would have the power to
        indemnify such Person against such expense, liability or loss under the MGCL.</font></div>
    <div style="text-align: justify; text-indent: 36pt; margin-bottom: 12pt;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif; font-weight: bold;">E.</font><font style="display: inline-block; text-indent: 0px; font-size: 1px;
        width: 36pt" id="TRGRRTFtoHTMLTab">&#160;</font><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif; font-weight: bold;">Miscellaneous.&#160; </font>The
        Corporation shall not be liable for any payment under this Article&#160;10 in connection with a claim made by any indemnitee to the extent such indemnitee has otherwise actually received payment under any insurance policy, agreement, or otherwise, of
        the amounts otherwise indemnifiable hereunder.&#160; The rights to indemnification and to the advancement of expenses conferred in Sections&#160;A and B of this Article&#160;10 shall be contract rights and such rights shall continue as to an indemnitee who has
        ceased to be a director or officer and shall inure to the benefit of the indemnitee&#8217;s heirs, executors and administrators.</font></div>
    <div style="text-align: justify; text-indent: 36pt; margin-bottom: 12pt;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">Any repeal or modification of this Article&#160;10 shall not in any way diminish any rights to
        indemnification or advancement of expenses of such director or officer or the obligations of the Corporation arising hereunder with respect to events occurring, or claims made, while this Article&#160;11 is in force.</font></div>
    <div style="text-align: justify; text-indent: 36pt; margin-bottom: 12pt;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif; font-weight: bold;">ARTICLE&#160;11.&#160;







          Limitation of Liability.&#160; </font>An officer or director of the Corporation, as such, shall not be liable to the Corporation or its stockholders for money damages, except (A)&#160;to the extent that it is proved that the Person actually received an
        improper benefit or profit in money, property or services for the amount of the benefit or profit in money, property or services actually received; (B) to the extent that a judgment or other final adjudication adverse to the Person is entered in a
        proceeding based on a finding in the proceeding that the Person&#8217;s action, or failure to act, was the result of active and deliberate dishonesty and was material to the cause of action adjudicated in the proceeding; or (C)&#160;to the extent otherwise
        provided by the MGCL.&#160; If the MGCL is amended to further eliminate or limit the Personal liability of officers and directors, then the liability of officers and directors of the Corporation shall be eliminated or limited to the fullest extent
        permitted by the MGCL, as so amended.</font></div>
    <div style="text-align: justify; text-indent: 36pt; margin-bottom: 12pt;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">Any repeal or modification of the foregoing paragraph by the stockholders of the Corporation shall
        not adversely affect any right or protection of a director or officer of the Corporation existing at the time of such repeal or modification.</font></div>
    <div style="text-align: justify;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif; font-weight: bold;">Item 7.&#160; Exemption From Registration Claimed.</font></div>
    <div><br>
    </div>
    <div style="text-align: justify; text-indent: 36pt;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">Not applicable.</font></div>
    <div><br>
    </div>
    <div style="text-align: justify;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif; font-weight: bold;">Item 8.&#160; List of Exhibits.</font></div>
    <div><br>
    </div>
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            <div style="text-align: center;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">Regulation S-K</font></div>
            <div style="text-align: center;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">Exhibit Number</font></div>
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          <td style="width: 5.22%; vertical-align: bottom;">&#160;</td>
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            <div style="text-align: center;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">Document</font></div>
          </td>
          <td style="width: 5.22%; vertical-align: bottom;">&#160;</td>
          <td style="width: 29.98%; vertical-align: bottom; border-bottom: #000000 2px solid;">
            <div style="text-align: center;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">Reference to Prior Filing or</font></div>
            <div style="text-align: center;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">Exhibit No. Attached Hereto</font></div>
          </td>
        </tr>
        <tr>
          <td style="width: 19.85%; vertical-align: top;">&#160;</td>
          <td style="width: 5.22%; vertical-align: top;">&#160;</td>
          <td style="width: 39.72%; vertical-align: top;">&#160;</td>
          <td style="width: 5.22%; vertical-align: top;">&#160;</td>
          <td style="width: 29.98%; vertical-align: top;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 19.85%; vertical-align: top;">
            <div style="text-align: center;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">4</font></div>
          </td>
          <td style="width: 5.22%; vertical-align: top;">&#160;</td>
          <td style="width: 39.72%; vertical-align: top;">
            <div style="text-align: left;"><a href="http://www.sec.gov/Archives/edgar/data/1531031/000157104917005526/t1701677_ex4-1.htm"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">Form of Common Stock Certificate</font></a></div>
          </td>
          <td style="width: 5.22%; vertical-align: top;">&#160;</td>
          <td style="width: 29.98%; vertical-align: top;">
            <div style="text-align: left;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">*</font></div>
          </td>
        </tr>
        <tr>
          <td style="width: 19.85%; vertical-align: top;">&#160;</td>
          <td style="width: 5.22%; vertical-align: top;">&#160;</td>
          <td style="width: 39.72%; vertical-align: top;">&#160;</td>
          <td style="width: 5.22%; vertical-align: top;">&#160;</td>
          <td style="width: 29.98%; vertical-align: top;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 19.85%; vertical-align: top;">
            <div style="text-align: center;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">5</font></div>
          </td>
          <td style="width: 5.22%; vertical-align: top;">&#160;</td>
          <td style="width: 39.72%; vertical-align: top;">
            <div style="text-align: left;"><a href="ex5-s8_061419.htm"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">Opinion
                  of Luse Gorman, PC</font></a></div>
          </td>
          <td style="width: 5.22%; vertical-align: top;">&#160;</td>
          <td style="width: 29.98%; vertical-align: top;">
            <div style="text-align: left;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">Attached as Exhibit 5</font></div>
          </td>
        </tr>
        <tr>
          <td style="width: 19.85%; vertical-align: top;">&#160;</td>
          <td style="width: 5.22%; vertical-align: top;">&#160;</td>
          <td style="width: 39.72%; vertical-align: top;">&#160;</td>
          <td style="width: 5.22%; vertical-align: top;">&#160;</td>
          <td style="width: 29.98%; vertical-align: top;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 19.85%; vertical-align: top;">
            <div style="text-align: center;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">10.1</font></div>
          </td>
          <td style="width: 5.22%; vertical-align: top;">&#160;</td>
          <td style="width: 39.72%; vertical-align: top;">
            <div style="text-align: left;"><a href="http://www.sec.gov/Archives/edgar/data/1531031/000114420419020165/tv518956_def14a.htm"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">Esquire Financial Holdings, Inc. 2019
                  Equity Incentive Plan</font></a></div>
          </td>
          <td style="width: 5.22%; vertical-align: top;">&#160;</td>
          <td style="width: 29.98%; vertical-align: top;">
            <div style="text-align: left;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">**</font></div>
          </td>
        </tr>
        <tr>
          <td style="width: 19.85%; vertical-align: top;">&#160;</td>
          <td style="width: 5.22%; vertical-align: top;">&#160;</td>
          <td style="width: 39.72%; vertical-align: top;">&#160;</td>
          <td style="width: 5.22%; vertical-align: top;">&#160;</td>
          <td style="width: 29.98%; vertical-align: top;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 19.85%; vertical-align: top;">
            <div style="text-align: center;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">10.2</font></div>
          </td>
          <td style="width: 5.22%; vertical-align: top;">&#160;</td>
          <td style="width: 39.72%; vertical-align: top;">
            <div style="text-align: left;"><a href="ex10-2_s8061419.htm"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">Form of
                  Restricted Stock Award Agreement</font></a></div>
          </td>
          <td style="width: 5.22%; vertical-align: top;">&#160;</td>
          <td style="width: 29.98%; vertical-align: top;">
            <div style="text-align: left;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">Attached as Exhibit 10.2</font></div>
          </td>
        </tr>
        <tr>
          <td style="width: 19.85%; vertical-align: top;">&#160;</td>
          <td style="width: 5.22%; vertical-align: top;">&#160;</td>
          <td style="width: 39.72%; vertical-align: top;">&#160;</td>
          <td style="width: 5.22%; vertical-align: top;">&#160;</td>
          <td style="width: 29.98%; vertical-align: top;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 19.85%; vertical-align: top;">
            <div style="text-align: center;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">10.3</font></div>
          </td>
          <td style="width: 5.22%; vertical-align: top;">&#160;</td>
          <td style="width: 39.72%; vertical-align: top;">
            <div style="text-align: left;"><a href="ex10-3_s8061419.htm"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">Form of
                  Incentive Stock Option Award Agreement</font></a></div>
          </td>
          <td style="width: 5.22%; vertical-align: top;">&#160;</td>
          <td style="width: 29.98%; vertical-align: top;">
            <div style="text-align: left;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">Attached as Exhibit 10.3</font></div>
          </td>
        </tr>
        <tr>
          <td style="width: 19.85%; vertical-align: top;">&#160;</td>
          <td style="width: 5.22%; vertical-align: top;">&#160;</td>
          <td style="width: 39.72%; vertical-align: top;">&#160;</td>
          <td style="width: 5.22%; vertical-align: top;">&#160;</td>
          <td style="width: 29.98%; vertical-align: top;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 19.85%; vertical-align: top;">
            <div style="text-align: center;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">10.4</font></div>
          </td>
          <td style="width: 5.22%; vertical-align: top;">&#160;</td>
          <td style="width: 39.72%; vertical-align: top;">
            <div style="text-align: left;"><a href="ex10-4_s8061419.htm"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">Form of
                  Non-Qualified Stock Option Award Agreement</font></a></div>
          </td>
          <td style="width: 5.22%; vertical-align: top;">&#160;</td>
          <td style="width: 29.98%; vertical-align: top;">
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          <td style="width: 19.85%; vertical-align: top;">&#160;</td>
          <td style="width: 5.22%; vertical-align: top;">&#160;</td>
          <td style="width: 39.72%; vertical-align: top;">&#160;</td>
          <td style="width: 5.22%; vertical-align: top;">&#160;</td>
          <td style="width: 29.98%; vertical-align: top;">&#160;</td>
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          <td style="width: 39.72%; vertical-align: top;">
            <div style="text-align: left;"><a href="ex5-s8_061419.htm"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">Consent
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          <td style="width: 5.22%; vertical-align: top;">&#160;</td>
          <td style="width: 29.98%; vertical-align: top;">
            <div style="text-align: left;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">Contained in Exhibit 5</font></div>
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          <td style="width: 19.85%; vertical-align: top;">&#160;</td>
          <td style="width: 5.22%; vertical-align: top;">&#160;</td>
          <td style="width: 39.72%; vertical-align: top;">&#160;</td>
          <td style="width: 5.22%; vertical-align: top;">&#160;</td>
          <td style="width: 29.98%; vertical-align: top;">&#160;</td>
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        <tr>
          <td style="width: 19.85%; vertical-align: top;">
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          <td style="width: 5.22%; vertical-align: top;">&#160;</td>
          <td style="width: 39.72%; vertical-align: top;">
            <div style="text-align: left;"><a href="ex23-2_s8061419.htm"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">Consent
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          <td style="width: 5.22%; vertical-align: top;">&#160;</td>
          <td style="width: 29.98%; vertical-align: top;">
            <div style="text-align: left;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">Attached as Exhibit 23.2</font></div>
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          <td style="width: 19.85%; vertical-align: top;">&#160;</td>
          <td style="width: 5.22%; vertical-align: top;">&#160;</td>
          <td style="width: 39.72%; vertical-align: top;">&#160;</td>
          <td style="width: 5.22%; vertical-align: top;">&#160;</td>
          <td style="width: 29.98%; vertical-align: top;">&#160;</td>
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        <tr>
          <td style="width: 19.85%; vertical-align: top;">
            <div style="text-align: center;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">24</font></div>
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          <td style="width: 39.72%; vertical-align: top;">
            <div style="text-align: left;"><a href="#POWEROFATTORNEY"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">Power of Attorney</font></a></div>
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          <td style="width: 5.22%; vertical-align: top;">&#160;</td>
          <td style="width: 29.98%; vertical-align: top;">
            <div style="text-align: left;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">Contained on Signature Page</font></div>
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    <div style="text-align: left;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">_________________________</font></div>
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            <tr>
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                <div><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">Incorporated by reference to Exhibit&#160;4.1 in the Registration Statement on Form S-1 (File No. 333-218372) originally filed by the Company under the Securities
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              </td>
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        </table>
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    <div style="text-align: justify;">
      <div>
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                <div><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">Incorporated by reference to Appendix A to the proxy statement for the Annual
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    <div style="text-align: justify; text-indent: -27.35pt; margin-left: 27.35pt;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif; font-weight: bold;">Item 9.&#160; Undertakings</font></div>
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    <div style="text-align: justify; text-indent: 36pt; margin-bottom: 12pt;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">The undersigned Registrant hereby undertakes:</font></div>
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              <div style="text-align: justify; margin-bottom: 12pt;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">To file, during any period in which offers or sales are being made, a post-effective amendment to this
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    <div style="text-align: justify; margin-left: 72pt; margin-bottom: 12pt;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">(i)</font><font style="display: inline-block; text-indent: 0px; font-size: 1px; width: 36pt" id="TRGRRTFtoHTMLTab">&#160;</font><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">to include any prospectus required by Section 10(a)(3) of the Securities Act of 1933;</font></div>
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        offered (if the total dollar value of securities offered would not exceed that which was registered) and any deviation from the low or high end of the estimated maximum offering range may be reflected in the form of prospectus filed with the
        Commission pursuant to Rule 424(b) (section 230.424(b)) if, in the aggregate, the changes in volume and price represent no more than 20% change in the maximum aggregate offering price set forth in the &#8220;Calculation of Registration Fees&#8221; table in the
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    <div style="text-align: justify; margin-left: 72pt; margin-bottom: 12pt;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">(iii)</font><font style="display: inline-block; text-indent: 0px; font-size: 1px; width: 36pt" id="TRGRRTFtoHTMLTab">&#160;</font><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">to include any material information with respect to the plan of distribution not previously disclosed in this Registration Statement or any
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    <div style="text-align: justify; margin-bottom: 12pt;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif; font-style: italic;">provided, however</font>,
        that paragraphs 1(i) and 1(ii) above do not apply if the information required to be included in a post-effective amendment by these paragraphs is contained in reports filed with or furnished to the Commission by the Company pursuant to Section 13
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    <div style="text-align: justify; text-indent: 36pt; margin-bottom: 12pt;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">2.</font><font style="display: inline-block; text-indent: 0px; font-size: 1px; width: 36pt" id="TRGRRTFtoHTMLTab">&#160;</font><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">That, for the purpose of determining any liability under the Securities Act of 1933, each such post-effective amendment shall be deemed to be
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    <div style="text-align: justify; text-indent: 36pt; margin-bottom: 12pt;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">3.</font><font style="display: inline-block; text-indent: 0px; font-size: 1px; width: 36pt" id="TRGRRTFtoHTMLTab">&#160;</font><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">To remove from registration by means of a post-effective amendment any of the securities being registered which remain unsold at the
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    <div style="text-align: justify; text-indent: 36pt; margin-bottom: 12pt;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">4.</font><font style="display: inline-block; text-indent: 0px; font-size: 1px; width: 36pt" id="TRGRRTFtoHTMLTab">&#160;</font><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">That, for purposes of determining any liability under the Securities Act of 1933, each filing of the Registrant&#8217;s annual report pursuant to
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        is, therefore, unenforceable.&#160; In the event that a claim for indemnification against such liabilities (other than the payment by the Registrant of expenses incurred or paid by a director, officer or controlling person of the Registrant in the
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    <div style="text-align: center;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif; font-weight: bold;">SIGNATURES</font></div>
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    <div style="text-align: justify; text-indent: 36pt; margin-bottom: 12pt;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif; font-weight: bold;">The
          Registrant.</font>&#160; Pursuant to the requirements of the Securities Act of 1933, the Registrant certifies that it has reasonable grounds to believe that it meets all of the requirements for filing on Form S-8 and has duly caused this Registration
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          <td style="width: 41.92%; vertical-align: top;">&#160;</td>
          <td style="width: 9.92%; vertical-align: top;">&#160;</td>
          <td style="width: 48.16%; vertical-align: top;">
            <div style="text-align: justify;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif; font-weight: bold;">ESQUIRE FINANCIAL HOLDINGS, INC.</font></div>
          </td>
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          <td style="width: 41.92%; vertical-align: top;">&#160;</td>
          <td style="width: 9.92%; vertical-align: top;">&#160;</td>
          <td style="width: 48.16%; vertical-align: top;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 41.92%; vertical-align: top;">&#160;</td>
          <td style="width: 9.92%; vertical-align: top;">&#160;</td>
          <td style="width: 48.16%; vertical-align: top;">&#160;</td>
        </tr>
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          <td style="width: 41.92%; vertical-align: top;">&#160;</td>
          <td style="width: 9.92%; vertical-align: top;">
            <div style="text-align: right;"><font style="font-size: 10pt; font-family: &quot;Times New Roman&quot;,Times,serif;">By:&#160;&#160; <br>
              </font></div>
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          <td style="width: 48.16%; vertical-align: top; border-bottom: #000000 2px solid;">&#160;/s/ Andrew C. Sagliocca<br>
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          <td style="width: 41.92%; vertical-align: top;">&#160;</td>
          <td style="width: 9.92%; vertical-align: top;">&#160;</td>
          <td style="width: 48.16%; vertical-align: top;">
            <div style="text-align: justify;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">Andrew C. Sagliocca</font></div>
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          <td style="width: 41.92%; vertical-align: top;">&#160;</td>
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          <td style="width: 48.16%; vertical-align: top;">
            <div style="text-align: justify;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">President and Chief Executive Officer</font></div>
          </td>
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        <tr>
          <td style="width: 41.92%; vertical-align: top;">&#160;</td>
          <td style="width: 9.92%; vertical-align: top;">&#160;</td>
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            <div style="text-align: justify;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">(Duly Authorized Representative)</font></div>
          </td>
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    <div style="text-align: center;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif; font-weight: bold;"><a name="POWEROFATTORNEY"><!--Anchor--></a>POWER OF ATTORNEY</font></div>
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    <div style="text-align: justify; text-indent: 36pt; margin-bottom: 12pt;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">We, the undersigned directors and officers of Esquire Financial Holdings, Inc. (the &#8220;Company&#8221;) hereby
        severally constitute and appoint Andrew C. Sagliocca, as our true and lawful attorney and agent, to do any and all things in our names in the capacities indicated below which said Andrew C. Sagliocca may deem necessary or advisable to enable the
        Company to comply with the Securities Act of 1933, and any rules, regulations and requirements of the Securities and Exchange Commission, in connection with the registration of shares of common stock issued under the 2019 Equity Plan, including
        specifically, but not limited to, power and authority to sign for us in our names in the capacities indicated below the registration statement and any and all amendments (including post-effective amendments) thereto; and we hereby approve, ratify
        and confirm all that said Andrew C. Sagliocca shall do or cause to be done by virtue thereof.</font></div>
    <div style="text-align: justify; text-indent: 36pt; margin-bottom: 12pt;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">Pursuant to the requirements of the Securities Act of 1933, this Registration Statement on Form S-8
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          <td style="width: 3.72%; vertical-align: top;">&#160;</td>
          <td style="width: 38.14%; vertical-align: top; border-bottom: #000000 2px solid;">
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          <td style="width: 24.16%; vertical-align: top; border-bottom: #000000 2px solid;">
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          </td>
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          <td style="width: 28.43%; vertical-align: top;">&#160;</td>
          <td style="width: 3.72%; vertical-align: top;">&#160;</td>
          <td style="width: 38.14%; vertical-align: top;">&#160;</td>
          <td style="width: 5.56%; vertical-align: top;">&#160;</td>
          <td style="width: 24.16%; vertical-align: top;">&#160;</td>
        </tr>
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          <td style="width: 28.43%; vertical-align: top;">&#160;</td>
          <td style="width: 3.72%; vertical-align: top;">&#160;</td>
          <td style="width: 38.14%; vertical-align: top;">&#160;</td>
          <td style="width: 5.56%; vertical-align: top;">&#160;</td>
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            <div style="text-align: left;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">President, Chief Executive Officer and Director</font></div>
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          <td style="width: 24.16%; vertical-align: top;"> June 17, 2019<br>
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            <div style="text-align: left;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">(Principal Executive Officer)</font></div>
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          <td style="width: 5.56%; vertical-align: top;">&#160;</td>
          <td style="width: 24.16%; vertical-align: top;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 28.43%; vertical-align: top;">&#160;</td>
          <td style="width: 3.72%; vertical-align: top;">&#160;</td>
          <td style="width: 38.14%; vertical-align: top;">&#160;</td>
          <td style="width: 5.56%; vertical-align: top;">&#160;</td>
          <td style="width: 24.16%; vertical-align: top;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 28.43%; vertical-align: top;">&#160;</td>
          <td style="width: 3.72%; vertical-align: top;">&#160;</td>
          <td style="width: 38.14%; vertical-align: top;">&#160;</td>
          <td style="width: 5.56%; vertical-align: top;">&#160;</td>
          <td style="width: 24.16%; vertical-align: top;">&#160;</td>
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          <td style="width: 28.43%; vertical-align: top; border-bottom: #000000 2px solid;">&#160;/s/ <font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">Michael Lacapria</font></td>
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            <div style="text-align: left;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">Senior Vice President, Chief Financial Officer (Principal Financial and Accounting Officer)</font></div>
          </td>
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          </td>
          <td style="width: 24.16%; vertical-align: top;">June 17, 2019</td>
        </tr>
        <tr>
          <td style="width: 28.43%; vertical-align: top;">
            <div style="text-align: justify;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">Michael Lacapria</font></div>
          </td>
          <td style="width: 3.72%; vertical-align: top;">&#160;</td>
          <td style="width: 38.14%; vertical-align: top;">&#160;</td>
          <td style="width: 5.56%; vertical-align: top;"><br>
          </td>
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          <td style="width: 24.18%; vertical-align: top;"> June 17, 2019 </td>
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          <td style="width: 24.18%; vertical-align: top;">June 17, 2019</td>
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          <td style="width: 24.18%; vertical-align: top;">June 17, 2019</td>
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          <td style="width: 24.18%; vertical-align: top;"> June 17, 2019 </td>
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{"company-data": {"conformed-name": "Esquire Financial Holdings, Inc.", "cik": "0001531031", "assigned-sic": "6029", "irs-number": "000000000", "state-of-incorporation": "MD", "fiscal-year-end": "1231"}, "filing-values": {"form-type": "S-8", "act": "33", "file-number": "333-232164", "film-number": "19901728"}, "business-address": {"street1": "100 JERICHO QUADRANGLE", "street2": "SUITE 100", "city": "JERICHO", "state": "NY", "zip": "11753", "phone": "(800) 996-0213"}, "mail-address": {"street1": "100 JERICHO QUADRANGLE", "street2": "SUITE 100", "city": "JERICHO", "state": "NY", "zip": "11753"}}
Registration No. 333-_________
As filed with the Securities and Exchange
          Commission on June 17, 2019
UNITED STATES
SECURITIES AND EXCHANGE COMMISSION
Washington, D.C.  20549
_________________________
FORM S-8
REGISTRATION STATEMENT
UNDER
THE SECURITIES ACT OF 1933
Esquire Financial Holdings, Inc.
(Exact Name of Registrant as Specified in its Charter)
Maryland
27-5107901
(State or Other Jurisdiction of
(I.R.S. Employer Identification No.)
Incorporation or Organization)
100 Jericho Quadrangle, Suite 100Jericho, New
          York 11753
(Address of Principal Executive Offices)
Esquire Financial Holdings, Inc. 2019
          Incentive Plan
(Full Title of the Plans)
Copies to:
Mr. Andrew C. Sagliocca
John J. Gorman, Esquire
President and Chief Executive Officer
Gary A. Lax, Esquire
Esquire Financial Holdings, Inc.
Luse Gorman, PC
100 Jericho Quadrangle, Suite 100
5335 Wisconsin Ave., N.W., Suite 780
Jericho, New York 11753
Washington, DC 20015-2035
(516) 535-2002
(202) 274-2000
(Name, Address and Telephone
Number of Agent for Service)
Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, smaller reporting
        company, or an emerging growth company. See the definitions of "large accelerated filer," "accelerated filer," "smaller reporting company" and "emerging growth company" in Rule 12b-2 of the Securities Exchange Act of 1934, as amended (the "Exchange
        Act"):
Large accelerated filer
☐
Accelerated filer
☒
Non-accelerated filer
☐
(Do not check if a smaller
                reporting company)
Smaller reporting company
☒
Emerging growth company
☒
If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying
        with any new or revised financial accounting standards provided pursuant to Section 7(a)(2)(B) of the Securities Act.
☒
CALCULATION OF REGISTRATION FEE
Title of
Securities
to be
Registered
Amount
to be
Registered
Proposed
Maximum
Offering Price
Per Share
Proposed
Maximum
Aggregate
Offering Price
Amount of
Registration
Fee
Common stock, par value $0.01 per share
300,000
(1)
$24.70
(2)
$7,410,000
$899
_________________________
(1)
Together with an indeterminate number of additional shares that may be necessary to adjust the number of shares reserved for
                  issuance pursuant to the Esquire Financial Holdings, Inc. 2019 Equity Incentive Plan (the "2019 Equity Plan") as a result of a stock split, stock dividend or similar adjustment of the outstanding common stock of Esquire Financial
                  Holdings, Inc. (the "Company") pursuant to 17 C.F.R. Section 230.416(a).
(2)
Computed in accordance with Rule 457(h) under the Securities Act and based upon the high and low sales price of the Company's
                  Common Stock as reported on the NASDAQ Capital Market on June 11, 2019.
_________________________
This Registration Statement shall become effective upon filing in accordance with Section 8(a) of the Securities Act of
        1933 and 17 C.F.R. § 230.462.
PART I.
Items 1 and 2.  Plan Information and Registrant Information and Employee Plan Annual Information
The documents containing the information specified in Part I of Form S-8 have been or will be sent or
        given to participants in the Stock Benefit Plans as specified by Rule 428(b)(1) promulgated by the Securities and Exchange Commission (the "Commission") under the Securities Act of 1933, as amended (the "Securities Act").
Such documents are not being filed with the Commission, but constitute (along with the documents
        incorporated by reference into this Registration Statement pursuant to Item 3 of Part II hereof) a prospectus that meets the requirements of Section 10(a) of the Securities Act.
PART II.
Item 3.  Incorporation of Documents by Reference
The following documents previously or concurrently filed with the Commission are hereby incorporated
        by reference in this Registration Statement:
(a)
The Company's Annual Report on Form 10-K for the year ended December 31, 2018 (File No. 001-38131) filed with the Commission on March 14,
        2019 pursuant to Section 13(a) of the Securities Exchange Act of 1934, as amended (the "Echange Act");
(b)
All other reports filed by the Company pursuant to Section 13(a) or 15(d) of the Exchange Act since the end of the year covered by the Annual
        Report on Form 10-K filed by the Company referred in (a) above; and
(c)
The description of the Company's common stock contained in the
          Registration Statement on Form 8-A filed with the Commission on June 26, 2017 (File No. 001-38131).
All documents subsequently filed by the Company with the Commission pursuant to Sections 13(a),
        13(c), 14, or 15(d) of the Securities Exchange Act of 1934, as amended, after the date hereof, and prior to the filing of a post-effective amendment which indicates that all securities offered hereby have been sold or which deregisters all
        securities then remaining unsold, shall be deemed incorporated by reference into this Registration Statement and to be a part thereof from the date of the filing of such documents.  Any statement contained in the documents incorporated, or deemed
        to be incorporated, by reference herein or therein shall be deemed to be modified or superseded for purposes of this Registration Statement and the prospectus to the extent that a statement contained herein or therein or in any other subsequently
        filed document which also is, or is deemed to be, incorporated by reference herein or therein modifies or supersedes such statement.  Any such statement so modified or superseded shall not be deemed, except as so modified or superseded, to
        constitute a part of this Registration Statement and the prospectus.
All information appearing in this Registration Statement and the prospectus is qualified in its
        entirety by the detailed information, including financial statements, appearing in the documents incorporated herein or therein by reference.
Item 4.  Description of Securities
Not applicable.
Item 5.  Interests of Named Experts and Counsel
None.
Item 6.  Indemnification of Directors and Officers
Articles 10 and 11 of the Articles of Incorporation of Esquire Financial Holdings, Inc. (the "Corporation") set forth
        circumstances under which directors, officers, employees and agents of the Corporation may be insured or indemnified against liability which they incur in their capacities as such:
ARTICLE 10. Indemnification, etc. of
            Directors and Officers.
A.
Indemnification.
The
        Corporation shall indemnify (1) its current and former directors and officers, whether serving the Corporation or at its request any other entity, to the fullest extent required or permitted by the MGCL now or hereafter in force, including the
        advancement of expenses under the procedures and to the fullest extent permitted by law, and (2) other employees and agents to such extent as shall be authorized by the Board of Directors and permitted by law; provided, however, that, except as
        provided in Section B hereof with respect to proceedings to enforce rights to indemnification, the Corporation shall indemnify any such indemnitee in connection with a proceeding (or part thereof) initiated by such indemnitee only if such
        proceeding (or part thereof) was authorized by the Board of Directors of the Corporation.  The right to indemnification conferred in Section A of this Article 10 shall included the right to be paid by the Corporation the expenses incurred in
        defending any such proceeding in advance of its final disposition (hereinafter an "advancement of expenses"); provided, however, that if the MGCL requires an advancement of expenses incurred by an indemnitee in his or her capacity as a director or
        officers (and not in any other capacity in which service was or is rendered by such indemnitee, including, without limitation, service to an employee benefit plan) shall be made only upon delivery to the Corporation of a written undertaking
        (hereinafter an "undertaking"), by or on behalf of such indemnitee, to repay all amounts so advanced if it shall ultimately be determined by a final judicial decision from which there is no further right to appeal that such indemnitee is not
        entitled to be indemnified for such expenses under Section A of this Article 10 or otherwise.
B.
Procedure.
If a claim
        under Section A of this Article 10 is not paid in full by the Corporation within 60 days after a written claim has been received by the Corporation, except in the case of a claim for an advancement of expenses, in which case the applicable period
        shall be 20 days, the indemnitee may at any time thereafter bring suit against the Corporation to recover the unpaid amount of the claim.  If successful in whole or in part in any such suit, or in a suit brought by the Corporation to recover an
        advancement of expenses pursuant to the terms of an undertaking, the indemnitee shall also be entitled to be reimbursed the expense of prosecuting or defending such suit.  It shall be a defense to any action for advancement of expenses that the
        Corporation has not received both (i) an undertaking as required by law to repay such advances in the event it shall ultimately be determined that the standard of conduct has not been met and (ii) a written affirmation by the indemnitee of his good
        faith belief that the standard of conduct necessary for indemnification by the Corporation has been met.  In (i) any suit brought by the indemnitee to enforce a right to indemnification hereunder (but not in a suit brought by the indemnitee to
        enforce a right to an advancement of expenses) it shall be a defense that, and (ii) any suit by the Corporation to recover an advancement of expenses pursuant to the terms of an undertaking the Corporation shall be entitled to recover such expenses
        upon a final adjudication that, the indemnitee has not met the applicable standard for indemnification set forth in the MGCL.  Neither the failure of the Corporation (including its Board of Directors, independent legal counsel, or its stockholders)
        to have made a determination prior to the commencement of such suit that indemnification of the indemnitee is proper in the circumstances because the indemnitee has met the applicable standard of conduct set forth in the MGCL, nor an actual
        determination by the Corporation (including its Board of Directors, independent legal counsel, or its stockholders) that the indemnitee has not met such applicable standard of conduct, shall create a presumption that the indemnitee has not met the
        applicable standard of conduct or, in the case of such a suit brought by the indemnitee, be a defense to such suit.  In any suit brought by the indemnitee to enforce a right to indemnification or to an advancement of expenses hereunder, or by the
        Corporation to recover an advancement of expenses pursuant to the terms of an undertaking, the burden of proving that the indemnitee is not entitled to be indemnified, or to such advancement of expenses, under this Article 10 or otherwise shall be
        on the Corporation.
C.
Non-Exclusivity.
The
        rights to indemnification and to the advancement of expenses conferred in this Article 10 shall not be exclusive of any other right which any Person may have or hereafter acquire under any statute, these Articles, the Corporation's Bylaws, any
        agreement, any vote of stockholders or the Board of Directors, or otherwise.
D.
Insurance.
The
        Corporation may maintain insurance, at its expense, to protect itself and any director, officer, employee or agent of the Corporation or another corporation, partnership, joint venture, trust or
other enterprise against any expense, liability or loss, whether or not the Corporation would have the power to
        indemnify such Person against such expense, liability or loss under the MGCL.
E.
Miscellaneous.
The
        Corporation shall not be liable for any payment under this Article 10 in connection with a claim made by any indemnitee to the extent such indemnitee has otherwise actually received payment under any insurance policy, agreement, or otherwise, of
        the amounts otherwise indemnifiable hereunder.  The rights to indemnification and to the advancement of expenses conferred in Sections A and B of this Article 10 shall be contract rights and such rights shall continue as to an indemnitee who has
        ceased to be a director or officer and shall inure to the benefit of the indemnitee's heirs, executors and administrators.
Any repeal or modification of this Article 10 shall not in any way diminish any rights to
        indemnification or advancement of expenses of such director or officer or the obligations of the Corporation arising hereunder with respect to events occurring, or claims made, while this Article 11 is in force.
ARTICLE 11. 

          Limitation of Liability.
An officer or director of the Corporation, as such, shall not be liable to the Corporation or its stockholders for money damages, except (A) to the extent that it is proved that the Person actually received an
        improper benefit or profit in money, property or services for the amount of the benefit or profit in money, property or services actually received; (B) to the extent that a judgment or other final adjudication adverse to the Person is entered in a
        proceeding based on a finding in the proceeding that the Person's action, or failure to act, was the result of active and deliberate dishonesty and was material to the cause of action adjudicated in the proceeding; or (C) to the extent otherwise
        provided by the MGCL.  If the MGCL is amended to further eliminate or limit the Personal liability of officers and directors, then the liability of officers and directors of the Corporation shall be eliminated or limited to the fullest extent
        permitted by the MGCL, as so amended.
Any repeal or modification of the foregoing paragraph by the stockholders of the Corporation shall
        not adversely affect any right or protection of a director or officer of the Corporation existing at the time of such repeal or modification.
Item 7.  Exemption From Registration Claimed.
Not applicable.
Item 8.  List of Exhibits.
Regulation S-K
Exhibit Number
Document
Reference to Prior Filing or
Exhibit No. Attached Hereto
4
Form of Common Stock Certificate
*
5
Opinion
                  of Luse Gorman, PC
Attached as Exhibit 5
10.1
Esquire Financial Holdings, Inc. 2019
                  Equity Incentive Plan
**
10.2
Form of
                  Restricted Stock Award Agreement
Attached as Exhibit 10.2
10.3
Form of
                  Incentive Stock Option Award Agreement
Attached as Exhibit 10.3
10.4
Form of
                  Non-Qualified Stock Option Award Agreement
Attached as Exhibit 10.4
23.1
Consent
                  of Luse Gorman, PC
Contained in Exhibit 5
23.2
Consent
                  of Independent Registered Public Accounting Firm
Attached as Exhibit 23.2
24
Power of Attorney
Contained on Signature Page
_________________________
*
Incorporated by reference to Exhibit 4.1 in the Registration Statement on Form S-1 (File No. 333-218372) originally filed by the Company under the Securities
                    Act of 1933 with the Commission on May 31, 2017, and all amendments or reports filed thereto.
**
Incorporated by reference to Appendix A to the proxy statement for the Annual
                      Meeting of Stockholders of Esquire Financial Holdings, Inc. (File No. 001-38131), filed by Esquire Financial Holdings, Inc. under the Exchange Act on April 18, 2019
.
Item 9.  Undertakings
The undersigned Registrant hereby undertakes:
1.
To file, during any period in which offers or sales are being made, a post-effective amendment to this
                  Registration Statement;
(i)
to include any prospectus required by Section 10(a)(3) of the Securities Act of 1933;
(ii)
to reflect in the prospectus any facts or events arising after the effective date of the registration statement (or the most recent
        post-effective amendment thereof) which, individually or in the aggregate, represent a fundamental change in the information set forth in the registration statement.  Notwithstanding the foregoing, any increase or decrease in volume of securities
        offered (if the total dollar value of securities offered would not exceed that which was registered) and any deviation from the low or high end of the estimated maximum offering range may be reflected in the form of prospectus filed with the
        Commission pursuant to Rule 424(b) (section 230.424(b)) if, in the aggregate, the changes in volume and price represent no more than 20% change in the maximum aggregate offering price set forth in the "Calculation of Registration Fees" table in the
        effective registration statement;
(iii)
to include any material information with respect to the plan of distribution not previously disclosed in this Registration Statement or any
        material change to such information in this Registration Statement;
provided, however
,
        that paragraphs 1(i) and 1(ii) above do not apply if the information required to be included in a post-effective amendment by these paragraphs is contained in reports filed with or furnished to the Commission by the Company pursuant to Section 13
        or Section 15(d) of the Exchange Act that are incorporated by reference in this Registration Statement.
2.
That, for the purpose of determining any liability under the Securities Act of 1933, each such post-effective amendment shall be deemed to be
        a new Registration Statement relating to the securities offered therein, and the offering of such securities at that time shall be deemed to be the initial
bona fide
offering thereof;
3.
To remove from registration by means of a post-effective amendment any of the securities being registered which remain unsold at the
        termination of the Plan;
4.
That, for purposes of determining any liability under the Securities Act of 1933, each filing of the Registrant's annual report pursuant to
        Section 13(a) or 15(d) of the Exchange Act that is incorporated by reference in the Registration Statement shall be deemed to be a new Registration Statement relating to the securities offered therein, and the offering of such securities at that
        time shall be deemed to be the initial
bona fide
offering thereof; and
5.
Insofar as indemnification for liabilities arising under the Securities Act of 1933 may be permitted to directors, officers and controlling
        persons of the Registrant pursuant to the foregoing provisions, or otherwise, the Registrant has been advised that in the opinion of the Securities and Exchange Commission such indemnification is against public policy as expressed in the Act and
        is, therefore, unenforceable.  In the event that a claim for indemnification against such liabilities (other than the payment by the Registrant of expenses incurred or paid by a director, officer or controlling person of the Registrant in the
        successful defense of any action, suit or proceeding) is asserted by such director, officer or controlling person in connection with the securities being registered, the Registrant will, unless in the opinion of its counsel the matter has been
        settled by controlling precedent, submit to a
court of appropriate jurisdiction the question whether such indemnification by it is against public policy as
        expressed in the Act and will be governed by the final adjudication of such issue.
SIGNATURES
The
          Registrant.
Pursuant to the requirements of the Securities Act of 1933, the Registrant certifies that it has reasonable grounds to believe that it meets all of the requirements for filing on Form S-8 and has duly caused this Registration
        Statement on Form S-8 to be signed on its behalf by the undersigned, thereunto duly authorized, in the City of Jericho, State of New York, on this 17
th
day of June, 2019.
ESQUIRE FINANCIAL HOLDINGS, INC.
By:
/s/ Andrew C. Sagliocca
Andrew C. Sagliocca
President and Chief Executive Officer
(Duly Authorized Representative)
POWER OF ATTORNEY
We, the undersigned directors and officers of Esquire Financial Holdings, Inc. (the "Company") hereby
        severally constitute and appoint Andrew C. Sagliocca, as our true and lawful attorney and agent, to do any and all things in our names in the capacities indicated below which said Andrew C. Sagliocca may deem necessary or advisable to enable the
        Company to comply with the Securities Act of 1933, and any rules, regulations and requirements of the Securities and Exchange Commission, in connection with the registration of shares of common stock issued under the 2019 Equity Plan, including
        specifically, but not limited to, power and authority to sign for us in our names in the capacities indicated below the registration statement and any and all amendments (including post-effective amendments) thereto; and we hereby approve, ratify
        and confirm all that said Andrew C. Sagliocca shall do or cause to be done by virtue thereof.
Pursuant to the requirements of the Securities Act of 1933, this Registration Statement on Form S-8
        has been signed by the following persons in the capacities and on the date indicated.
Signatures
Title
Date
/s/
Andrew C. Sagliocca
President, Chief Executive Officer and Director
June 17, 2019
Andrew C. Sagliocca
(Principal Executive Officer)
/s/
Michael Lacapria
Senior Vice President, Chief Financial Officer (Principal Financial and Accounting Officer)
June 17, 2019
Michael Lacapria
/s/
Anthony Coelho
Chairman and Director
June 17, 2019
Anthony Coelho
Signatures
Title
Date
/s/
Todd Deutsch
Director
June 17, 2019
Todd Deutsch
/s/
Marc D. Grossman
Director
June 17, 2019
Marc D. Grossman
/s/
Russ M. Herman
Director
June 17, 2019
Russ M. Herman
/s/
Janet Hill
Director
June 17, 2019
Janet Hill
Director
Robert J. Mitzman
/s/
Richard T. Powers
Director
June 17, 2019
Richard T. Powers
/s/
Jack Thompson
Director
June 17, 2019
Jack Thompson
/s/
Kevin C. Waterhouse
Director
June 17, 2019
Kevin C. Waterhouse
/s/
Selig Zises
Director
June 17, 2019
Selig Zises