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<P align="center"><FONT size="2">As filed with the Securities and Exchange Commission on June&nbsp;6, 2002. Registration No.&nbsp;333-_____________</FONT>

<P align="center"><FONT size="2">SECURITIES AND EXCHANGE COMMISSION<BR>
WASHINGTON, D.C. 20549</FONT>

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<P align="center"><FONT size="2"><B>FORM S-8</B><BR>
REGISTRATION STATEMENT<BR>
UNDER<BR>
THE SECURITIES ACT OF 1933</FONT>

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<P align="center"><FONT size="2"><B>LA JOLLA PHARMACEUTICAL COMPANY</B><BR>
(Exact Name of Registrant as Specified in Its Charter)</FONT>

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        <TD align="center" valign="top"><FONT size="2"><B>Delaware</B><BR>
(State or Other Jurisdiction of Incorporation or Organization)</FONT></TD>
        <TD><FONT size="2">&nbsp;</FONT></TD>
        <TD align="center" valign="top"><FONT size="2">
<B>33-0361285</B><BR>
(I.R.S. Employer Identification No.)</FONT></TD>
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<P align="center"><FONT size="2"><B>6455 Nancy Ridge Drive<BR>
San Diego, California 92121<BR>
(858)&nbsp;452-6600</B><BR>
(Address, including Zip Code, and Telephone Number,<BR>
including Area Code, of Registrant&#146;s Principal Executive Offices)</FONT>

<P align="center"><FONT size="2"><B>LA JOLLA PHARMACEUTICAL COMPANY 1994 STOCK INCENTIVE PLAN<BR>
LA JOLLA PHARMACEUTICAL COMPANY 1995 EMPLOYEE STOCK<BR>
PURCHASE PLAN</B><BR>
(Full Title of Plan)</FONT>

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<P align="center"><FONT size="2">Steven B. Engle<BR>
La Jolla Pharmaceutical Company<BR>
6455 Nancy Ridge Drive<BR>
San Diego, California 92121<BR>
(858)&nbsp;452-6600<BR>
(Name, address, including zip code, and telephone number, including area code, of agent for service)</FONT>

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<P align="center"><FONT size="2">Copy to:<BR>
Mark W. Shurtleff, Esq.<BR>
Gibson, Dunn &#038; Crutcher LLP<BR>
4 Park Plaza, Suite&nbsp;1700<BR>
Irvine, California 92614<BR>
(949)&nbsp;451-3800</FONT>

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<P align="center"><FONT size="2">&nbsp;
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<P align="center"><FONT size="2"><B>CALCULATION OF REGISTRATION FEE</B></FONT>

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        <TD width="12%">&nbsp;</TD>
        <TD width="1%">&nbsp;</TD>
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        <TD width="1%">&nbsp;</TD>
        <TD width="8%">&nbsp;</TD>
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        <TD width="1%">&nbsp;</TD>
        <TD width="8%">&nbsp;</TD>
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        <TD width="1%">&nbsp;</TD>
        <TD width="1%">&nbsp;</TD>
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        <TD><FONT size="1">&nbsp;</FONT></TD>
        <TD><FONT size="1">&nbsp;</FONT></TD>
        <TD nowrap align="center" colspan="3"><FONT size="1"><B>PROPOSED</B></FONT></TD>
        <TD><FONT size="1">&nbsp;</FONT></TD>
        <TD nowrap align="center" colspan="3"><FONT size="1"><B>PROPOSED</B></FONT></TD>
        <TD><FONT size="1">&nbsp;</FONT></TD>
        <TD><FONT size="1">&nbsp;</FONT></TD>
        <TD><FONT size="1">&nbsp;</FONT></TD>
        <TD><FONT size="1">&nbsp;</FONT></TD>
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        <TD><FONT size="1">&nbsp;</FONT></TD>
        <TD><FONT size="1">&nbsp;</FONT></TD>
        <TD><FONT size="1">&nbsp;</FONT></TD>
        <TD><FONT size="1">&nbsp;</FONT></TD>
        <TD><FONT size="1">&nbsp;</FONT></TD>
        <TD><FONT size="1">&nbsp;</FONT></TD>
        <TD nowrap align="center" colspan="3"><FONT size="1"><B>MAXIMUM</B></FONT></TD>
        <TD><FONT size="1">&nbsp;</FONT></TD>
        <TD nowrap align="center" colspan="3"><FONT size="1"><B>MAXIMUM</B></FONT></TD>
        <TD><FONT size="1">&nbsp;</FONT></TD>
        <TD><FONT size="1">&nbsp;</FONT></TD>
        <TD><FONT size="1">&nbsp;</FONT></TD>
        <TD><FONT size="1">&nbsp;</FONT></TD>
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        <TD nowrap align="center"><FONT size="1"><B>TITLE OF SECURITIES</B></FONT></TD>
        <TD><FONT size="1">&nbsp;</FONT></TD>
        <TD nowrap align="center" colspan="3"><FONT size="1"><B>AMOUNT TO BE</B></FONT></TD>
        <TD><FONT size="1">&nbsp;</FONT></TD>
        <TD nowrap align="center" colspan="3"><FONT size="1"><B>OFFERING PRICE</B></FONT></TD>
        <TD><FONT size="1">&nbsp;</FONT></TD>
        <TD nowrap align="center" colspan="3"><FONT size="1"><B>AGGREGATE</B></FONT></TD>
        <TD><FONT size="1">&nbsp;</FONT></TD>
        <TD nowrap align="center" colspan="3"><FONT size="1"><B>AMOUNT OF</B></FONT></TD>
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        <TD nowrap align="center"><FONT size="1"><B>TO BE REGISTERED</B></FONT></TD>
        <TD><FONT size="1">&nbsp;</FONT></TD>
        <TD nowrap align="center" colspan="3"><FONT size="1"><B>REGISTERED(1)</B></FONT></TD>
        <TD><FONT size="1">&nbsp;</FONT></TD>
        <TD nowrap align="center" colspan="3"><FONT size="1"><B>PER SHARE(2)</B></FONT></TD>
        <TD><FONT size="1">&nbsp;</FONT></TD>
        <TD nowrap align="center" colspan="3"><FONT size="1"><B>OFFERING PRICE(2)</B></FONT></TD>
        <TD><FONT size="1">&nbsp;</FONT></TD>
        <TD nowrap align="center" colspan="3"><FONT size="1"><B>REGISTRATION FEE</B></FONT></TD>
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        <TD><DIV style="margin-left:10px; text-indent:-10px"><FONT size="2">Common Stock, par
value $0.01 per
share</FONT></DIV></TD>
        <TD><FONT size="2">&nbsp;</FONT></TD>
        <TD nowrap align="right"><FONT size="2">&nbsp;</FONT></TD>
        <TD align="right"><FONT size="2">2,100,000</FONT></TD>
        <TD nowrap><FONT size="2">(3)(4)</FONT></TD>
        <TD><FONT size="2">&nbsp;</FONT></TD>
        <TD align="right"><FONT size="2">$</FONT></TD>
        <TD><FONT size="2">5.33</FONT></TD>
        <TD><FONT size="2">&nbsp;</FONT></TD>
        <TD><FONT size="2">&nbsp;</FONT></TD>
        <TD align="right"><FONT size="2">$</FONT></TD>
        <TD><FONT size="2">11,193,000</FONT></TD>
        <TD><FONT size="2">&nbsp;</FONT></TD>
        <TD><FONT size="2">&nbsp;</FONT></TD>
        <TD align="right"><FONT size="2">$</FONT></TD>
        <TD><FONT size="2">1,030</FONT></TD>
        <TD><FONT size="2">&nbsp;</FONT></TD>
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      <TD width="1%" align="left" nowrap><FONT size="2">(1)</FONT></TD>
        <TD width="3%"><FONT size="2">&nbsp;</FONT></TD>
        <TD width="96%"><FONT size="2">Each share of common stock includes a right to purchase one
one-thousandth of a share of Series&nbsp;A Junior Participating Preferred Stock
pursuant to the Rights Agreement between the Registrant and American Stock
Transfer &#038; Trust Company, as Rights Agent, as amended. Pursuant to Rule
416(a), this Registration Statement also covers shares of common stock
issued pursuant to antidilution provisions set forth in the La Jolla
Pharmaceutical Company 1994 Stock Incentive Plan and the La Jolla
Pharmaceutical Company 1995 Employee Stock Purchase Plan.</FONT></TD>
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      <TD width="1%" align="left" nowrap><FONT size="2">(2)</FONT></TD>
        <TD width="3%"><FONT size="2">&nbsp;</FONT></TD>
        <TD width="96%"><FONT size="2">Estimated solely for the purpose of calculating the registration fee
pursuant to Rules&nbsp;457(c) and 457(h) and based on the average of the high
and the low price of the common stock of the Registrant as reported on
May&nbsp;30, 2002 on the Nasdaq National Market System.</FONT></TD>
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<TR><TD><TR><TD><TR><TD><TR><TD>
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      <TD width="1%" align="left" nowrap><FONT size="2">(3)</FONT></TD>
        <TD width="3%"><FONT size="2">&nbsp;</FONT></TD>
        <TD width="96%"><FONT size="2">Represents a 1,900,000 share increase in the number of shares authorized
for issuance under the La Jolla Pharmaceutical Company 1994 Stock
Incentive Plan. 7,100,000 shares of our common stock are issuable under
the 1994 Stock Incentive Plan. In addition to the shares of common stock
registered hereby, 750,000 shares of our common stock issuable under the
1994 Stock Incentive Plan were previously registered under the
Registration Statement on Form&nbsp;S-8 (Registration No.&nbsp;33-82664) as filed
with the Securities and Exchange Commission on August&nbsp;11, 1994; 500,000
shares of our common stock issuable under the 1994 Stock Incentive Plan
were previously registered under the Registration Statement on Form&nbsp;S-8
(Registration No.&nbsp;333-14285) as filed with the Securities and Exchange
Commission on October&nbsp;17, 1996; 500,000 shares of our common stock
issuable under the 1994 Stock Incentive Plan were previously registered
under the Registration Statement on Form&nbsp;S-8 (Registration No.&nbsp;333-29575)
as filed with the Securities and Exchange Commission on June&nbsp;19, 1997;
750,000 shares of our common stock issuable under the 1994 Stock Incentive
Plan were previously registered under the Registration Statement on Form
S-8 (Registration No.&nbsp;333-91593) as filed with the Securities and Exchange
Commission on November&nbsp;24, 1999; 1,000,000 shares of our common stock
issuable under the 1994 Stock Incentive Plan were previously registered
under the Registration Statement on Form&nbsp;S-8 (Registration No.&nbsp;333-45080)
as filed with the Securities and Exchange Commission on September&nbsp;1, 2000;
and 1,700,000 shares of our common stock issuable under the 1994 Stock
Incentive Plan were previously registered under the Registration Statement
on Form&nbsp;S-8 (Registration No.&nbsp;333-69104) as filed with the Securities and
Exchange Commission on September&nbsp;7, 2001.</FONT></TD>
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<TR><TD><TR><TD><TR><TD><TR><TD>
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      <TD width="1%" align="left" nowrap><FONT size="2">(4)</FONT></TD>
        <TD width="3%"><FONT size="2">&nbsp;</FONT></TD>
        <TD width="96%"><FONT size="2">Represents a 200,000 share increase in the number of shares authorized
for issuance under the La Jolla Pharmaceutical Company 1995 Employee Stock
Purchase Plan. 1,000,000 shares of our common stock are issuable under the
1995 Employee Stock Purchase Plan. In addition to the shares of common
stock registered hereby, 300,000 shares of our common stock issuable under
the 1995 Employee Stock Purchase Plan were previously registered under the
Registration Statement on Form&nbsp;S-8 (Registration No.&nbsp;33-94830) as filed
with the Securities and Exchange Commission on July&nbsp;21, 1995; 200,000
shares of our common stock issuable under the 1995 Employee Stock Purchase
Plan were previously registered under the Registration Statement on Form
S-8 (Registration No.&nbsp;333-45080) as filed with the Securities and Exchange
Commission on September&nbsp;1, 2000; and 300,000 shares of our common stock
issuable under the 1995 Employee Stock Purchase Plan were previously
registered under the Registration Statement on Form&nbsp;S-8 (Registration No.
333-69104) as filed with the Securities and Exchange Commission on
September&nbsp;7, 2001.</FONT></TD>
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<TR><TD colspan="9"><A HREF="#000">PART I<BR> INFORMATION REQUIRED IN THE SECTION 10(a) PROSPECTUS</A></TD></TR>
<TR><TD colspan="9"><A HREF="#001">PART II<BR> INFORMATION REQUIRED IN THE REGISTRATION STATEMENT</A></TD></TR>
<TR><TD></TD><TD colspan="8"><A HREF="#002">Item&nbsp;8. Exhibits.</A></TD></TR>
<TR><TD colspan="9"><A HREF="#003">SIGNATURES</A></TD></TR>
<TR><TD colspan="9"><A HREF="#004">EXHIBIT INDEX</A></TD></TR>
<TR><TD colspan="9"><A HREF="a82196orexv5w1.txt">EXHIBIT 5.1</A></TD></TR>
<TR><TD colspan="9"><A HREF="a82196orexv23w1.txt">EXHIBIT 23.1</A></TD></TR>
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<P align="center"><FONT size="2"><B>INTRODUCTION</B></FONT>

<P><FONT size="2">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;We are filing this Registration Statement on Form&nbsp;S-8 to register an
additional 1,900,000 shares of our common stock that we may issue under our
1994 Stock Incentive Plan and an additional 200,000 shares of our common stock
that we may issue under our 1995 Employee Stock Purchase Plan. We have
included in this Registration Statement only those items required by General
Instruction E to Form&nbsp;S-8.
</FONT>
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<P align="center"><FONT size="2"><B>PART I<BR>
INFORMATION REQUIRED IN THE SECTION 10(a) PROSPECTUS</B></FONT>

<P><FONT size="2">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Information required by Part I of Form&nbsp;S-8 to be contained in the Section
10(a) prospectus is omitted from this Registration Statement in accordance with
Rule&nbsp;428 under the Securities Act of 1933, as amended, and the Note to Part I
of Form&nbsp;S-8.
</FONT>
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<P align="center"><FONT size="2"><B>PART II<BR>
INFORMATION REQUIRED IN THE REGISTRATION STATEMENT</B></FONT>

<P><FONT size="2">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;In accordance with General Instruction E to Form&nbsp;S-8, the contents of our
Registration Statement on Form&nbsp;S-8 (Registration No.&nbsp;33-82664) previously filed
by us with the Securities and Exchange Commission on August&nbsp;11, 1994 relating
to the 1994 Stock Incentive Plan, and the contents of our Registration
Statement on Form&nbsp;S-8 (Registration No.&nbsp;33-94830) previously filed by us with
the Securities and Exchange Commission on July&nbsp;21, 1995 relating to the 1995
Employee Stock Purchase Plan, are incorporated herein by reference and made a
part hereof. In addition, the contents of our Registration Statement on Form
S-8 (Registration No.&nbsp;333-69104) previously filed by us with the Securities and
Exchange Commission on September&nbsp;7, 2001, which Registration Statement contains
updated information under the heading &#147;Indemnification of Officers and
Directors&#148; and &#147;Undertakings,&#148; is incorporated herein by reference and made a
part hereof.
</FONT>
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<P align="left"><FONT size="2"><B>Item&nbsp;8. Exhibits.</B></FONT>

<P><FONT size="2">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Pursuant to General Instruction E, only those opinions and consents
required by Item&nbsp;8 are provided. They are as follows:
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        <TD nowrap align="center"><FONT size="1">Exhibit</FONT></TD>
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        <TD nowrap align="center"><FONT size="1">Number</FONT></TD>
        <TD><FONT size="1">&nbsp;</FONT></TD>
        <TD nowrap align="left"><FONT size="1">Description</FONT></TD>
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        <TD align="center" valign="top"><FONT size="2">&nbsp;&nbsp;5.1</FONT></TD>
        <TD><FONT size="2">&nbsp;</FONT></TD>
        <TD align="left" valign="top"><FONT size="2">
Opinion of Gibson, Dunn &#038; Crutcher LLP</FONT></TD>
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<TR><TD>&nbsp;</TD></TR>
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        <TD align="center" valign="top"><FONT size="2">23.1</FONT></TD>
        <TD><FONT size="2">&nbsp;</FONT></TD>
        <TD align="left" valign="top"><FONT size="2">
Consent of Ernst &#038; Young LLP, independent auditors</FONT></TD>
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        <TD align="center" valign="top"><FONT size="2">23.2</FONT></TD>
        <TD><FONT size="2">&nbsp;</FONT></TD>
        <TD align="left" valign="top"><FONT size="2">
Consent of Gibson, Dunn &#038; Crutcher LLP (contained in Exhibit&nbsp;5.1 hereto)</FONT></TD>
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<TR><TD>&nbsp;</TD></TR>
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        <TD  align="center" valign="top"><FONT size="2">24.1</FONT></TD>
        <TD><FONT size="2">&nbsp;</FONT></TD>
        <TD align="left" valign="top"><FONT size="2">
Power of Attorney (contained on signature page hereto)</FONT></TD>
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<P align="center"><FONT size="2">&nbsp;
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<DIV align="left"><A NAME="003"></A></DIV>
<P align="center"><FONT size="2"><B>SIGNATURES</B></FONT>

<P><FONT size="2">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Pursuant to the requirements of the Securities Act of 1933, the registrant
certifies that it has reasonable grounds to believe that it meets all of the
requirements for filing on Form&nbsp;S-8 and has duly caused this Registration
Statement to be signed on its behalf by the undersigned, thereunto duly
authorized, in the City of San Diego, State of California, on June&nbsp;6, 2002.
</FONT>
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        <TD><FONT size="2">&nbsp;</FONT></TD>
        <TD colspan="2"><FONT size="2"><B>LA JOLLA PHARMACEUTICAL COMPANY</B></FONT></TD>
</TR>

<TR><TD>&nbsp;<BR>&nbsp;</TD></TR>
<TR>
        <TD><FONT size="2">&nbsp;</FONT></TD>
        <TD><FONT size="2">By:&nbsp;</FONT></TD>
        <TD><FONT size="2">/s/ Steven B. Engle</FONT></TD>

</TR>
<TR>
        <TD colspan="2"><FONT size="1">&nbsp;</FONT></TD>
        <TD><HR size="1" noshade color="#000000"></TD>
</TR>
<TR valign="top">
        <TD colspan="2">&nbsp;</TD>
        <TD><FONT size="2">
Steven B. Engle<BR>
Chairman and Chief Executive Officer</FONT></TD>
</TR>
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<P align="center"><FONT size="2"><B>POWER OF ATTORNEY</B></FONT>

<P><FONT size="2">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Each person whose signature appears below constitutes and appoints Steven
B. Engle and Gail A. Sloan his or her true and lawful attorneys-in-fact and
agents, each acting alone, with full powers of substitution and resubstitution,
for him or her and in his or her name, place and stead, in any and all
capacities, to sign any and all amendments (including post-effective
amendments) to this Registration Statement and to file the same, with all
exhibits thereto, and other documents in connection therewith, with the
Securities and Exchange Commission, granting unto said attorneys-in-fact and
agents, each acting alone, full power and authority to do and perform each and
every act and thing requisite and necessary to be done in and about the
premises, as full to all intents and purposes as he or she might or could do in
person, hereby ratifying and confirming all that said attorneys-in-fact and
agents, each acting alone, or his substitute or substitutes, may lawfully do or
cause to be done by virtue hereof.
</FONT>
<P><FONT size="2">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Pursuant to the requirements of the Securities Act of 1933, this
Registration Statement has been signed below by the following persons in the
capacities indicated below and on the date indicated.
</FONT>
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        <TD nowrap align="center"><FONT size="1"><B>Signature</B></FONT></TD>
        <TD><FONT size="1">&nbsp;</FONT></TD>
        <TD nowrap align="center"><FONT size="1"><B>Title</B></FONT></TD>
        <TD><FONT size="1">&nbsp;</FONT></TD>
        <TD nowrap align="center"><FONT size="1"><B>Date</B></FONT></TD>
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        <TD><FONT size="1">&nbsp;</FONT></TD>
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<TR><TD>&nbsp;</TD></TR>
<TR valign="bottom">
        <TD align="center" valign="top"><FONT size="2">/s/&nbsp;&nbsp;Steven B.
Engle<BR><hR size="1" noshade>
Steven B. Engle</FONT></TD>
        <TD><FONT size="2">&nbsp;</FONT></TD>
        <TD align="center" valign="top"><FONT size="2">
Chairman and Chief Executive Officer<BR>
(Principal Executive Officer)
</FONT></TD>
        <TD><FONT size="2">&nbsp;</FONT></TD>
        <TD align="center" valign="top"><FONT size="2">June&nbsp;6, 2002</FONT></TD>
</TR>
<TR><TD>&nbsp;</TD></TR>
<TR>

<TD align="center" valign="top"><FONT size="2">/s/&nbsp;&nbsp;Gail A.
Sloan<BR><HR size="1" noshade>
Gail A. Sloan</FONT></TD>
        <TD><FONT size="2">&nbsp;</FONT></TD>
        <TD align="center" valign="top"><FONT size="2">
Secretary and Controller<BR>
(Principal Financial and Accounting Officer)
</FONT></TD>
        <TD><FONT size="2">&nbsp;</FONT></TD>
        <TD align="center" valign="top"><FONT size="2">June&nbsp;6, 2002</FONT></TD>
</TR>
<TR><TD>&nbsp;</TD></TR>
<TR>

<TD align="center" valign="top"><FONT size="2">/s/&nbsp;&nbsp;Thomas
H. Adams, Ph.D.<HR size="1" noshade>
Thomas H. Adams, Ph.D.</FONT></TD>
        <TD><FONT size="2">&nbsp;</FONT></TD>
        <TD align="center" valign="top"><FONT size="2">
Director
</FONT></TD>
        <TD><FONT size="2">&nbsp;</FONT></TD>
        <TD align="center" valign="top"><FONT size="2">June&nbsp;6, 2002</FONT></TD>
</TR>
<TR><TD>&nbsp;</TD></TR>
<TR>

<TD align="center" valign="top"><FONT size="2">/s/&nbsp;&nbsp;William
E. Engbers<BR><HR size="1" noshade>
William E. Engbers</FONT></TD>
        <TD><FONT size="2">&nbsp;</FONT></TD>
        <TD align="center" valign="top"><FONT size="2">
Director
</FONT></TD>
        <TD><FONT size="2">&nbsp;</FONT></TD>
        <TD align="center" valign="top"><FONT size="2">June&nbsp;6, 2002</FONT></TD>
</TR>
<TR><TD>&nbsp;</TD></TR>
<TR>

<TD align="center" valign="top"><FONT size="2">/s/&nbsp;&nbsp;Robert
A. Fildes, Ph.D.<BR><HR size="1" noshade>
Robert A. Fildes, Ph.D.</FONT></TD>
        <TD><FONT size="2">&nbsp;</FONT></TD>
        <TD align="center" valign="top"><FONT size="2">
Director
</FONT></TD>
        <TD><FONT size="2">&nbsp;</FONT></TD>
        <TD align="center" valign="top"><FONT size="2">June&nbsp;6, 2002</FONT></TD>
</TR>
<TR><TD>&nbsp;</TD></TR>
<TR>

<TD align="center" valign="top"><FONT size="2">/s/&nbsp;&nbsp;Stephen
M. Martin<BR><HR size="1" noshade>
Stephen M. Martin</FONT></TD>
        <TD><FONT size="2">&nbsp;</FONT></TD>
        <TD align="center" valign="top"><FONT size="2">
Director
</FONT></TD>
        <TD><FONT size="2">&nbsp;</FONT></TD>
        <TD align="center" valign="top"><FONT size="2">June&nbsp;6, 2002</FONT></TD>
</TR>
<TR><TD>&nbsp;</TD></TR>
<TR>

<TD align="center" valign="top"><FONT size="2"><BR><HR size="1" noshade>
William R. Ringo</FONT></TD>
        <TD><FONT size="2">&nbsp;</FONT></TD>
        <TD align="center" valign="top"><FONT size="2">
Director
</FONT></TD>
        <TD><FONT size="2">&nbsp;</FONT></TD>
        <TD align="center" valign="top"><FONT size="2">June&nbsp;6, 2002</FONT></TD>
</TR>
<TR><TD>&nbsp;</TD></TR>
<TR>

<TD align="center" valign="top"><FONT size="2">/s/&nbsp;&nbsp;W.
Leigh Thompson, M.D., Ph.D.<HR size="1" noshade>
W. Leigh Thompson, M.D., Ph.D.</FONT></TD>
        <TD><FONT size="2">&nbsp;</FONT></TD>
        <TD align="center" valign="top"><FONT size="2">
Director
</FONT></TD>
        <TD><FONT size="2">&nbsp;</FONT></TD>
        <TD align="center" valign="top"><FONT size="2">June&nbsp;6, 2002</FONT></TD>
</TR>
</TABLE>
</CENTER>
<P align="center"><FONT size="2">&nbsp;
</FONT>

<!-- PAGEBREAK -->
<P><HR noshade><P>
<H5 align="left" style="page-break-before:always"><A HREF="#toc">Table of Contents</A></H5><P>
<!-- link1 "EXHIBIT INDEX" -->
<DIV align="left"><A NAME="004"></A></DIV>
<P align="center"><FONT size="2"><B>EXHIBIT INDEX</B></FONT>

<CENTER>
<TABLE cellspacing="0" border="0" cellpadding="0" width="85%">
<TR valign="bottom">
        <TD width="6%">&nbsp;</TD>
        <TD width="5%">&nbsp;</TD>
        <TD width="89%">&nbsp;</TD>
</TR>
<TR valign="bottom">
        <TD nowrap align="center"><FONT size="1">Exhibit</FONT></TD>
        <TD><FONT size="1">&nbsp;</FONT></TD>
        <TD><FONT size="1">&nbsp;</FONT></TD>
</TR>
<TR valign="bottom">
        <TD nowrap align="center"><FONT size="1">Number</FONT></TD>
        <TD><FONT size="1">&nbsp;</FONT></TD>
        <TD nowrap align="left"><FONT size="1">Description</FONT></TD>
</TR>
<TR valign="bottom">
        <TD nowrap align="center"><HR size="1" noshade></TD>
        <TD><FONT size="1">&nbsp;</FONT></TD>
        <TD nowrap align="center"><HR size="1" noshade></TD>
</TR>
<TR><TD>&nbsp;</TD></TR>
<TR valign="bottom">
        <TD align="center" valign="top"><FONT size="2">&nbsp;&nbsp;5.1</FONT></TD>
        <TD><FONT size="2">&nbsp;</FONT></TD>
        <TD align="left" valign="top"><FONT size="2">
Opinion of Gibson, Dunn &#038; Crutcher LLP</FONT></TD>
</TR>
<TR><TD>&nbsp;</TD></TR>
<TR valign="bottom">
        <TD align="center" valign="top"><FONT size="2">23.1</FONT></TD>
        <TD><FONT size="2">&nbsp;</FONT></TD>
        <TD align="left" valign="top"><FONT size="2">
Consent of Ernst &#038; Young LLP, independent auditors</FONT></TD>
</TR>
<TR><TD>&nbsp;</TD></TR>
<TR valign="bottom">
        <TD align="center" valign="top"><FONT size="2">23.2</FONT></TD>
        <TD><FONT size="2">&nbsp;</FONT></TD>
        <TD align="left" valign="top"><FONT size="2">
Consent of Gibson, Dunn &#038; Crutcher LLP (contained in Exhibit&nbsp;5.1 hereto)</FONT></TD>
</TR>
<TR><TD>&nbsp;</TD></TR>
<TR valign="bottom">
        <TD  align="center" valign="top"><FONT size="2">24.1</FONT></TD>
        <TD><FONT size="2">&nbsp;</FONT></TD>
        <TD align="left" valign="top"><FONT size="2">
Power of Attorney (contained on signature page hereto)</FONT></TD>
</TR>
</TABLE>
</CENTER>

<P align="center"><FONT size="2">&nbsp;</FONT>

</BODY>
</HTML>
[{"type": "S-8", "sequence": "1", "filename": "a82196orsv8.htm", "description": "FORM S-8", "secsgml_size_bytes": 28372}]
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La Jolla Pharmaceutical Company
Table of Contents
As filed with the Securities and Exchange Commission on June 6, 2002. Registration No. 333-_____________
SECURITIES AND EXCHANGE COMMISSION
WASHINGTON, D.C. 20549
FORM S-8
REGISTRATION STATEMENT
UNDER
THE SECURITIES ACT OF 1933
LA JOLLA PHARMACEUTICAL COMPANY
(Exact Name of Registrant as Specified in Its Charter)
Delaware
(State or Other Jurisdiction of Incorporation or Organization)
33-0361285
(I.R.S. Employer Identification No.)
6455 Nancy Ridge Drive
San Diego, California 92121
(858) 452-6600
(Address, including Zip Code, and Telephone Number,
including Area Code, of Registrant's Principal Executive Offices)
LA JOLLA PHARMACEUTICAL COMPANY 1994 STOCK INCENTIVE PLAN
LA JOLLA PHARMACEUTICAL COMPANY 1995 EMPLOYEE STOCK
PURCHASE PLAN
(Full Title of Plan)
Steven B. Engle
La Jolla Pharmaceutical Company
6455 Nancy Ridge Drive
San Diego, California 92121
(858) 452-6600
(Name, address, including zip code, and telephone number, including area code, of agent for service)
Copy to:
Mark W. Shurtleff, Esq.
Gibson, Dunn & Crutcher LLP
4 Park Plaza, Suite 1700
Irvine, California 92614
(949) 451-3800
Table of Contents
CALCULATION OF REGISTRATION FEE
PROPOSED
PROPOSED
MAXIMUM
MAXIMUM
TITLE OF SECURITIES
AMOUNT TO BE
OFFERING PRICE
AGGREGATE
AMOUNT OF
TO BE REGISTERED
REGISTERED(1)
PER SHARE(2)
OFFERING PRICE(2)
REGISTRATION FEE
Common Stock, par
value $0.01 per
share
2,100,000
(3)(4)
$
5.33
$
11,193,000
$
1,030
(1)
Each share of common stock includes a right to purchase one
one-thousandth of a share of Series A Junior Participating Preferred Stock
pursuant to the Rights Agreement between the Registrant and American Stock
Transfer & Trust Company, as Rights Agent, as amended. Pursuant to Rule
416(a), this Registration Statement also covers shares of common stock
issued pursuant to antidilution provisions set forth in the La Jolla
Pharmaceutical Company 1994 Stock Incentive Plan and the La Jolla
Pharmaceutical Company 1995 Employee Stock Purchase Plan.
(2)
Estimated solely for the purpose of calculating the registration fee
pursuant to Rules 457(c) and 457(h) and based on the average of the high
and the low price of the common stock of the Registrant as reported on
May 30, 2002 on the Nasdaq National Market System.
(3)
Represents a 1,900,000 share increase in the number of shares authorized
for issuance under the La Jolla Pharmaceutical Company 1994 Stock
Incentive Plan. 7,100,000 shares of our common stock are issuable under
the 1994 Stock Incentive Plan. In addition to the shares of common stock
registered hereby, 750,000 shares of our common stock issuable under the
1994 Stock Incentive Plan were previously registered under the
Registration Statement on Form S-8 (Registration No. 33-82664) as filed
with the Securities and Exchange Commission on August 11, 1994; 500,000
shares of our common stock issuable under the 1994 Stock Incentive Plan
were previously registered under the Registration Statement on Form S-8
(Registration No. 333-14285) as filed with the Securities and Exchange
Commission on October 17, 1996; 500,000 shares of our common stock
issuable under the 1994 Stock Incentive Plan were previously registered
under the Registration Statement on Form S-8 (Registration No. 333-29575)
as filed with the Securities and Exchange Commission on June 19, 1997;
750,000 shares of our common stock issuable under the 1994 Stock Incentive
Plan were previously registered under the Registration Statement on Form
S-8 (Registration No. 333-91593) as filed with the Securities and Exchange
Commission on November 24, 1999; 1,000,000 shares of our common stock
issuable under the 1994 Stock Incentive Plan were previously registered
under the Registration Statement on Form S-8 (Registration No. 333-45080)
as filed with the Securities and Exchange Commission on September 1, 2000;
and 1,700,000 shares of our common stock issuable under the 1994 Stock
Incentive Plan were previously registered under the Registration Statement
on Form S-8 (Registration No. 333-69104) as filed with the Securities and
Exchange Commission on September 7, 2001.
(4)
Represents a 200,000 share increase in the number of shares authorized
for issuance under the La Jolla Pharmaceutical Company 1995 Employee Stock
Purchase Plan. 1,000,000 shares of our common stock are issuable under the
1995 Employee Stock Purchase Plan. In addition to the shares of common
stock registered hereby, 300,000 shares of our common stock issuable under
the 1995 Employee Stock Purchase Plan were previously registered under the
Registration Statement on Form S-8 (Registration No. 33-94830) as filed
with the Securities and Exchange Commission on July 21, 1995; 200,000
shares of our common stock issuable under the 1995 Employee Stock Purchase
Plan were previously registered under the Registration Statement on Form
S-8 (Registration No. 333-45080) as filed with the Securities and Exchange
Commission on September 1, 2000; and 300,000 shares of our common stock
issuable under the 1995 Employee Stock Purchase Plan were previously
registered under the Registration Statement on Form S-8 (Registration No.
333-69104) as filed with the Securities and Exchange Commission on
September 7, 2001.
TABLE OF CONTENTS
PART I
INFORMATION REQUIRED IN THE SECTION 10(a) PROSPECTUS
PART II
INFORMATION REQUIRED IN THE REGISTRATION STATEMENT
Item 8. Exhibits.
SIGNATURES
EXHIBIT INDEX
EXHIBIT 5.1
EXHIBIT 23.1
Table of Contents
INTRODUCTION
We are filing this Registration Statement on Form S-8 to register an
additional 1,900,000 shares of our common stock that we may issue under our
1994 Stock Incentive Plan and an additional 200,000 shares of our common stock
that we may issue under our 1995 Employee Stock Purchase Plan. We have
included in this Registration Statement only those items required by General
Instruction E to Form S-8.
PART I
INFORMATION REQUIRED IN THE SECTION 10(a) PROSPECTUS
Information required by Part I of Form S-8 to be contained in the Section
10(a) prospectus is omitted from this Registration Statement in accordance with
Rule 428 under the Securities Act of 1933, as amended, and the Note to Part I
of Form S-8.
PART II
INFORMATION REQUIRED IN THE REGISTRATION STATEMENT
In accordance with General Instruction E to Form S-8, the contents of our
Registration Statement on Form S-8 (Registration No. 33-82664) previously filed
by us with the Securities and Exchange Commission on August 11, 1994 relating
to the 1994 Stock Incentive Plan, and the contents of our Registration
Statement on Form S-8 (Registration No. 33-94830) previously filed by us with
the Securities and Exchange Commission on July 21, 1995 relating to the 1995
Employee Stock Purchase Plan, are incorporated herein by reference and made a
part hereof. In addition, the contents of our Registration Statement on Form
S-8 (Registration No. 333-69104) previously filed by us with the Securities and
Exchange Commission on September 7, 2001, which Registration Statement contains
updated information under the heading "Indemnification of Officers and
Directors" and "Undertakings," is incorporated herein by reference and made a
part hereof.
Item 8. Exhibits.
Pursuant to General Instruction E, only those opinions and consents
required by Item 8 are provided. They are as follows:
Exhibit
Number
Description
5.1
Opinion of Gibson, Dunn & Crutcher LLP
23.1
Consent of Ernst & Young LLP, independent auditors
23.2
Consent of Gibson, Dunn & Crutcher LLP (contained in Exhibit 5.1 hereto)
24.1
Power of Attorney (contained on signature page hereto)
Table of Contents
SIGNATURES
Pursuant to the requirements of the Securities Act of 1933, the registrant
certifies that it has reasonable grounds to believe that it meets all of the
requirements for filing on Form S-8 and has duly caused this Registration
Statement to be signed on its behalf by the undersigned, thereunto duly
authorized, in the City of San Diego, State of California, on June 6, 2002.
LA JOLLA PHARMACEUTICAL COMPANY
By:
/s/ Steven B. Engle
Steven B. Engle
Chairman and Chief Executive Officer
POWER OF ATTORNEY
Each person whose signature appears below constitutes and appoints Steven
B. Engle and Gail A. Sloan his or her true and lawful attorneys-in-fact and
agents, each acting alone, with full powers of substitution and resubstitution,
for him or her and in his or her name, place and stead, in any and all
capacities, to sign any and all amendments (including post-effective
amendments) to this Registration Statement and to file the same, with all
exhibits thereto, and other documents in connection therewith, with the
Securities and Exchange Commission, granting unto said attorneys-in-fact and
agents, each acting alone, full power and authority to do and perform each and
every act and thing requisite and necessary to be done in and about the
premises, as full to all intents and purposes as he or she might or could do in
person, hereby ratifying and confirming all that said attorneys-in-fact and
agents, each acting alone, or his substitute or substitutes, may lawfully do or
cause to be done by virtue hereof.
Pursuant to the requirements of the Securities Act of 1933, this
Registration Statement has been signed below by the following persons in the
capacities indicated below and on the date indicated.
Signature
Title
Date
/s/  Steven B.
Engle
Steven B. Engle
Chairman and Chief Executive Officer
(Principal Executive Officer)
June 6, 2002
/s/  Gail A.
Sloan
Gail A. Sloan
Secretary and Controller
(Principal Financial and Accounting Officer)
June 6, 2002
/s/  Thomas
H. Adams, Ph.D.
Thomas H. Adams, Ph.D.
Director
June 6, 2002
/s/  William
E. Engbers
William E. Engbers
Director
June 6, 2002
/s/  Robert
A. Fildes, Ph.D.
Robert A. Fildes, Ph.D.
Director
June 6, 2002
/s/  Stephen
M. Martin
Stephen M. Martin
Director
June 6, 2002
William R. Ringo
Director
June 6, 2002
/s/  W.
Leigh Thompson, M.D., Ph.D.
W. Leigh Thompson, M.D., Ph.D.
Director
June 6, 2002
Table of Contents
EXHIBIT INDEX
Exhibit
Number
Description
5.1
Opinion of Gibson, Dunn & Crutcher LLP
23.1
Consent of Ernst & Young LLP, independent auditors
23.2
Consent of Gibson, Dunn & Crutcher LLP (contained in Exhibit 5.1 hereto)
24.1
Power of Attorney (contained on signature page hereto)