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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>As filed with the Securities and Exchange
Commission on August 20, 2015</B></P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: right; border-bottom: Black 4.5pt double"><B>Registration
No. 333-&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</B></P>

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<P STYLE="font: 14pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>UNITED STATES</B>&nbsp;</P>

<P STYLE="font: 14pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>SECURITIES AND EXCHANGE COMMISSION</B>&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>Washington, D.C. 20549</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

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<P STYLE="font: 14pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>FORM S-8</B>&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>REGISTRATION STATEMENT</B><BR>
<B>UNDER THE SECURITIES ACT OF 1933</B>&nbsp;</P>

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<P STYLE="font: 14pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>&nbsp;</B></P>

<P STYLE="font: 14pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>BIOTIE THERAPIES OYJ</B>&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>(Exact Name of Registrant as specified
in its charter)</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<table cellspacing="0" cellpadding="0" style="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
<tr style="vertical-align: top">
    <td style="width: 29%; font-size: 8pt; text-align: center; font-weight: bold">Republic of Finland</td>
    <td style="width: 40%; font-size: 8pt">&nbsp;</td>
    <td style="width: 31%; font-size: 8pt; text-align: center; font-weight: bold">NOT APPLICABLE</td></tr>
<tr style="vertical-align: top">
    <td style="font-size: 10pt; text-align: center"><font style="font-size: 10pt">(State or other jurisdiction of </font><br>
<font style="font-size: 10pt">incorporation or organization)</font></td>
    <td style="font-size: 10pt">&nbsp;</td>
    <td style="font-size: 10pt; text-align: center"><font style="font-size: 10pt">(I.R.S. Employer </font><br>
<font style="font-size: 10pt">Identification No.)</font></td></tr>
<tr style="vertical-align: top">
    <td style="font-size: 8pt">&nbsp;</td>
    <td>
        <P STYLE="font: 8pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>Joukahaisenkatu 6, FI-20520</B>&nbsp;</P>
        <P STYLE="font: 8pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>Turku, Finland</B>&nbsp;</P>
        <P STYLE="font: 8pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><b>(+358) 2 274-8900</b></P>
        <P STYLE="font: 8pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"></P></td>
    <td style="font-size: 8pt">&nbsp;</td></tr>
<tr style="vertical-align: top">
    <td colspan="3" style="font-size: 8pt; text-align: center"><font style="font-size: 8pt">(Address including zip code of Principal Executive Offices) </font></td></tr>
<tr style="vertical-align: top">
    <td style="font-size: 8pt">&nbsp;</td>
    <td>
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    <td style="font-size: 8pt">&nbsp;</td></tr>
<tr>
    <td colspan="3">
        <P STYLE="font: 8pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>Biotie Therapies Corp. Stock
Option Plan 2014</B>&nbsp;</P>
        <P STYLE="font: 8pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>Biotie Therapies Corp. Equity
Incentive Plan 2014 </B>&nbsp;</P>
        <P STYLE="font: 8pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>Biotie Therapies Corp. Stock
Option Plan 2011</B>&nbsp;</P>
        <P STYLE="font: 8pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>Biotie Therapies AG 2008 Stock
Option Incentive Plan</B>&nbsp;</P></td></tr>
<TR>
    <TD COLSPAN="3">&nbsp;</TD></TR>
<tr>
    <td style="vertical-align: top; font-size: 8pt">&nbsp;</td>
    <td style="font-size: 8pt; text-align: center"><font style="font-size: 8pt">(Full title of the plans)</font></td>
    <td style="vertical-align: top; font-size: 8pt">&nbsp;</td></tr>
<TR>
    <TD STYLE="vertical-align: top; font-size: 8pt">&nbsp;</TD>
    <TD STYLE="font-size: 8pt; text-align: center">&nbsp;</TD>
    <TD STYLE="vertical-align: top; font-size: 8pt">&nbsp;</TD></TR>
<tr style="vertical-align: top">
    <td style="font-size: 8pt">&nbsp;</td>
    <td>
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    <td style="font-size: 8pt">&nbsp;</td></tr>
<tr style="vertical-align: top">
    <td colspan="3">
        <P STYLE="font: 8pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>Biotie Therapies, Inc.</B>&nbsp;</P>
        <P STYLE="font: 8pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>701 Gateway Boulevard &mdash;
Suite 350</B>&nbsp;</P>
        <P STYLE="font: 8pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>South San Francisco, CA 94080</B>&nbsp;</P>
        <P STYLE="font: 8pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><b>(650) 244-4850</b></P>
        <P STYLE="font: 8pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P></td></tr>
<tr style="vertical-align: top">
    <td style="font-size: 8pt">&nbsp;</td>
    <td>
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    <td style="font-size: 8pt">&nbsp;</td></tr>
<tr>
    <td colspan="3" style="font-size: 8pt; text-align: center"><font style="font-size: 8pt">(Name, address and telephone number, including area code, of agent for service)</font></td></tr>
<TR>
    <TD COLSPAN="3" STYLE="font-size: 8pt; text-align: center">&nbsp;</TD></TR>
<tr style="vertical-align: top">
    <td colspan="3">
        <P STYLE="font: 8pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><b>Copies to:</b></P>
        <P STYLE="font: 8pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>
        <P STYLE="font: 8pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>Jean M. McLoughlin</B>&nbsp;</P>
        <P STYLE="font: 8pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>Sophia Hudson</B>&nbsp;</P>
        <P STYLE="font: 8pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>Davis Polk &amp; Wardwell LLP</B>&nbsp;</P>
        <P STYLE="font: 8pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><b>450 Lexington Avenue</b></P>
        <P STYLE="font: 8pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"></P>
        <P STYLE="font: 8pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><b>New York, NY 10017</b></P>
        <P STYLE="font: 8pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P></td></tr>
<tr style="vertical-align: top">
    <td style="font-size: 8pt">&nbsp;</td>
    <td>
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    <td style="font-size: 8pt">&nbsp;</td></tr>
<tr style="vertical-align: top">
    <td style="font-size: 8pt">&nbsp;</td>
    <td>
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    <td style="font-size: 8pt">&nbsp;</td></tr>
</table>
<P STYLE="font: 8pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><B>Indicate by check mark whether the registrant
is a large accelerated filer, an accelerated filer, a non-accelerated filer, or a smaller reporting company. See the definitions
of &ldquo;large accelerated filer,&rdquo; &ldquo;accelerated filer&rdquo; and &ldquo;smaller reporting company&rdquo; in Rule 12b-2
of the Exchange Act.</B></P>

<P STYLE="font: 8pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;&nbsp;</P>

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    <TD STYLE="width: 63%; font-size: 8pt; text-indent: 24pt"><FONT STYLE="font-size: 8pt"><B>Large accelerated filer </B></FONT>[_]</TD>
    <TD STYLE="width: 37%; font-size: 8pt"><FONT STYLE="font-size: 8pt"><B>Accelerated filer </B></FONT>[_]</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="font-size: 8pt; text-indent: 36pt">&nbsp;</TD>
    <TD STYLE="font-size: 8pt">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="font-size: 8pt; text-indent: 24pt"><FONT STYLE="font-size: 8pt"><B>Non-accelerated filer </B></FONT>[X]<FONT STYLE="font-size: 8pt"><B>&nbsp;(Do not check if a smaller reporting company)</B></FONT></TD>
    <TD STYLE="font-size: 8pt"><FONT STYLE="font-size: 8pt"><B>Smaller reporting company </B></FONT>[_]</TD></TR>
</TABLE>


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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 27.5pt">&nbsp;</P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 27.5pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>CALCULATION OF REGISTRATION FEE</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<table cellspacing="0" cellpadding="0" style="width: 100%; font: 10pt Times New Roman, Times, Serif; border-collapse: collapse">
<tr style="vertical-align: bottom">
    <TD STYLE="width: 40%; border-top: black 2.25pt double; border-right: black 1pt solid; border-bottom: black 1pt solid; text-align: center; font-weight: bold; padding-right: 2pt; padding-left: 2pt"><font style="font-size: 10pt">Title of Securities to be Registered</font></td>
    <TD STYLE="width: 14%; border-top: black 2.25pt double; border-right: black 1pt solid; border-bottom: black 1pt solid; text-align: center; font-weight: bold; padding-right: 2pt; padding-left: 2pt"><font style="font-size: 10pt">Amount to be<font style="font-weight: normal"> </font>Registered (1)</font></td>
    <TD STYLE="width: 15%; border-top: black 2.25pt double; border-right: black 1pt solid; border-bottom: black 1pt solid; text-align: center; font-weight: bold; padding-right: 2pt; padding-left: 2pt"><font style="font-size: 10pt">Proposed Maximum Offering Price Per&nbsp;Share (2)</font></td>
    <TD STYLE="width: 18%; border-top: black 2.25pt double; border-right: black 1pt solid; border-bottom: black 1pt solid; text-align: center; font-weight: bold; padding-right: 2pt; padding-left: 2pt"><font style="font-size: 10pt">Proposed Maximum&nbsp;&nbsp;Aggregate<font style="font-weight: normal"> </font>Offering&nbsp;Price (2)</font></td>
    <TD STYLE="width: 13%; border-top: black 2.25pt double; border-bottom: black 1pt solid; text-align: center; font-weight: bold; padding-right: 2pt; padding-left: 2pt"><font style="font-size: 10pt">Amount of<font style="font-weight: normal"> </font>Registration Fee (2)</font></td></tr>
<tr style="vertical-align: bottom">
    <TD STYLE="border-right: black 1pt solid; border-bottom: black 1pt solid; padding-right: 2pt; padding-left: 2pt">Shares, no nominal value, reserved for issuance pursuant to the:</td>
    <TD STYLE="border-right: black 1pt solid; border-bottom: black 1pt solid; text-align: right; padding-right: 2pt; padding-left: 2pt"><font style="font-size: 10pt">&mdash;</font></td>
    <TD STYLE="border-right: black 1pt solid; border-bottom: black 1pt solid; text-align: right; padding-right: 2pt; padding-left: 2pt"><font style="font-size: 10pt">&mdash;</font></td>
    <TD STYLE="border-right: black 1pt solid; border-bottom: black 1pt solid; text-align: right; padding-right: 2pt; padding-left: 2pt"><font style="font-size: 10pt">&mdash;</font></td>
    <TD STYLE="border-bottom: black 1pt solid; text-align: right; padding-right: 2pt; padding-left: 2pt"><font style="font-size: 10pt">&mdash;</font></td></tr>
<tr style="vertical-align: bottom">
    <TD STYLE="border-right: black 1pt solid; border-bottom: black 1pt solid; padding-right: 2pt; padding-left: 2pt">- Biotie Therapies Corp. Stock Option Plan 2014</td>
    <TD STYLE="border-right: black 1pt solid; border-bottom: black 1pt solid; text-align: right; padding-right: 2pt; padding-left: 2pt"><font style="font-size: 10pt">8,465,000</font></td>
    <TD STYLE="border-right: black 1pt solid; border-bottom: black 1pt solid; text-align: right; padding-right: 2pt; padding-left: 2pt"><font style="font-size: 10pt">$0.01 (3)</font></td>
    <TD STYLE="border-right: black 1pt solid; border-bottom: black 1pt solid; text-align: right; padding-right: 2pt; padding-left: 2pt"><font style="font-size: 10pt">$93,961.50</font></td>
    <TD STYLE="border-bottom: black 1pt solid; text-align: right; padding-right: 2pt; padding-left: 2pt"><font style="font-size: 10pt">$10.92</font></td></tr>
<tr style="vertical-align: bottom">
    <TD STYLE="border-right: black 1pt solid; border-bottom: black 1pt solid; padding-right: 2pt; padding-left: 2pt">- Biotie Therapies Corp. Equity Incentive Plan 2014 </td>
    <TD STYLE="border-right: black 1pt solid; border-bottom: black 1pt solid; text-align: right; padding-right: 2pt; padding-left: 2pt"><font style="font-size: 10pt">14,002,500</font></td>
    <TD STYLE="border-right: black 1pt solid; border-bottom: black 1pt solid; text-align: right; padding-right: 2pt; padding-left: 2pt"><font style="font-size: 10pt">$0.24 (4)</font></td>
    <TD STYLE="border-right: black 1pt solid; border-bottom: black 1pt solid; text-align: right; padding-right: 2pt; padding-left: 2pt"><font style="font-size: 10pt">$3,326,153.85</font></td>
    <TD STYLE="border-bottom: black 1pt solid; text-align: right; padding-right: 2pt; padding-left: 2pt"><font style="font-size: 10pt">$386.50</font></td></tr>
<tr style="vertical-align: bottom">
    <TD STYLE="border-right: black 1pt solid; border-bottom: black 1pt solid; padding-right: 2pt; padding-left: 2pt">Shares, no nominal value, reserved for issuance pursuant to share option awards outstanding under the: </td>
    <TD STYLE="border-right: black 1pt solid; border-bottom: black 1pt solid; text-align: right; padding-right: 2pt; padding-left: 2pt"><font style="font-size: 10pt">&mdash;</font></td>
    <TD STYLE="border-right: black 1pt solid; border-bottom: black 1pt solid; text-align: right; padding-right: 2pt; padding-left: 2pt"><font style="font-size: 10pt">&mdash;</font></td>
    <TD STYLE="border-right: black 1pt solid; border-bottom: black 1pt solid; text-align: right; padding-right: 2pt; padding-left: 2pt"><font style="font-size: 10pt">&mdash;</font></td>
    <TD STYLE="border-bottom: black 1pt solid; text-align: right; padding-right: 2pt; padding-left: 2pt"><font style="font-size: 10pt">&mdash;</font></td></tr>
<tr style="vertical-align: bottom">
    <TD STYLE="border-right: black 1pt solid; border-bottom: black 1pt solid; padding-right: 2pt; padding-left: 2pt">- Biotie Therapies Corp. Stock Option Plan 2014</td>
    <TD STYLE="border-right: black 1pt solid; border-bottom: black 1pt solid; text-align: right; padding-right: 2pt; padding-left: 2pt"><font style="font-size: 10pt">1,490,000</font></td>
    <TD STYLE="border-right: black 1pt solid; border-bottom: black 1pt solid; text-align: right; padding-right: 2pt; padding-left: 2pt"><font style="font-size: 10pt">$0.01 (3)</font></td>
    <TD STYLE="border-right: black 1pt solid; border-bottom: black 1pt solid; text-align: right; padding-right: 2pt; padding-left: 2pt"><font style="font-size: 10pt">$16,539.00</font></td>
    <TD STYLE="border-bottom: black 1pt solid; text-align: right; padding-right: 2pt; padding-left: 2pt"><font style="font-size: 10pt">$1.92</font></td></tr>
<tr style="vertical-align: bottom">
    <TD STYLE="border-right: black 1pt solid; border-bottom: black 1pt solid; padding-right: 2pt; padding-left: 2pt">- Biotie Therapies Corp. Stock Option Plan 2011</td>
    <TD STYLE="border-right: black 1pt solid; border-bottom: black 1pt solid; text-align: right; padding-right: 2pt; padding-left: 2pt"><font style="font-size: 10pt">1,957,500</font></td>
    <TD STYLE="border-right: black 1pt solid; border-bottom: black 1pt solid; text-align: right; padding-right: 2pt; padding-left: 2pt"><font style="font-size: 10pt">$0.01 (3)</font></td>
    <TD STYLE="border-right: black 1pt solid; border-bottom: black 1pt solid; text-align: right; padding-right: 2pt; padding-left: 2pt"><font style="font-size: 10pt">$21,728.25</font></td>
    <TD STYLE="border-bottom: black 1pt solid; text-align: right; padding-right: 2pt; padding-left: 2pt"><font style="font-size: 10pt">$2.52</font></td></tr>
<tr style="vertical-align: bottom">
    <TD STYLE="border-right: black 1pt solid; border-bottom: black 1pt solid; padding-right: 2pt; padding-left: 2pt">- Biotie Therapies AG 2008 Stock Option Incentive Plan</td>
    <TD STYLE="border-right: black 1pt solid; border-bottom: black 1pt solid; text-align: right; padding-right: 2pt; padding-left: 2pt"><font style="font-size: 10pt">2,053,134</font></td>
    <TD STYLE="border-right: black 1pt solid; border-bottom: black 1pt solid; text-align: right; padding-right: 2pt; padding-left: 2pt"><font style="font-size: 10pt">$0.33 (3)</font></td>
    <TD STYLE="border-right: black 1pt solid; border-bottom: black 1pt solid; text-align: right; padding-right: 2pt; padding-left: 2pt"><font style="font-size: 10pt">$673,296.66</font></td>
    <TD STYLE="border-bottom: black 1pt solid; text-align: right; padding-right: 2pt; padding-left: 2pt"><font style="font-size: 10pt">$78.24</font></td></tr>
<tr style="vertical-align: bottom">
    <TD STYLE="border-right: black 1pt solid; border-bottom: black 1pt solid; padding-right: 2pt; padding-left: 2pt"><b>Total</b></td>
    <TD STYLE="border-right: black 1pt solid; border-bottom: black 1pt solid; text-align: right; padding-right: 2pt; padding-left: 2pt"><font style="font-size: 10pt"><b>27,968,134</b></font></td>
    <TD STYLE="border-right: black 1pt solid; border-bottom: black 1pt solid; text-align: right; padding-right: 2pt; padding-left: 2pt"><font style="font-size: 10pt"><b>N/A</b></font></td>
    <TD STYLE="border-right: black 1pt solid; border-bottom: black 1pt solid; text-align: right; padding-right: 2pt; padding-left: 2pt"><font style="font-size: 10pt"><b>$4,131,679.26</b></font></td>
    <TD STYLE="border-bottom: black 1pt solid; text-align: right; padding-right: 2pt; padding-left: 2pt"><font style="font-size: 10pt"><b>$480.10</b></font></td></tr>
</table>
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<TD STYLE="width: 0"></TD><TD STYLE="width: 0.25in">(1)</TD><TD>This Registration Statement on Form S-8 (this &ldquo;<B>Registration Statement</B>&rdquo;) covers shares, no nominal value,
of Biotie Therapies Oyj (the &ldquo;<B>Registrant</B>&rdquo;) (such shares, the &ldquo;<B>Shares</B>&rdquo;), which may be represented
by American Depositary Shares, or ADSs, with each ADS representing 80 Shares, issuable pursuant to the plans set forth in this
table (collectively, the &ldquo;<B>Plans</B>&rdquo;). The Registrant&rsquo;s ADSs issuable upon deposit of the Shares registered
hereby have been registered under a separate registration statement on Form F-6 (File No. 333-204707). Pursuant to Rule 416(a)
under the Securities Act of 1933, as amended (the &ldquo;<B>Securities Act</B>&rdquo;), this Registration Statement shall also
cover any additional Shares that become issuable under any of the Plans by reason of any share dividend, share split or other similar
transaction.</TD></TR></TABLE>

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<TD STYLE="width: 0"></TD><TD STYLE="width: 0.25in">(2)</TD><TD>Rounded up to the nearest penny.</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0"></TD><TD STYLE="width: 0.25in">(3)</TD><TD>Estimated pursuant to Rule 457(h)(1) under the Securities Act, solely for the purpose of computing the registration fee, based
on the weighted average per share exercise price of the options outstanding under the applicable Plan. The exercise prices for
options granted pursuant to the Biotie Therapies Corp. Stock Option Plan 2014 and the Biotie Therapies Corp. Stock Option Plan
2011 have been converted from Euros to U.S. dollars at an exchange rate of $1.11 per Euro, the Euro Foreign Exchange Reference
rate of the European Central Bank for the Euro on August 17, 2015. The exercise prices for options granted pursuant to the Biotie
Therapies AG 2008 Stock Option Incentive Plan have been converted from Swiss francs to U.S. dollars at an exchange rate of CHF
0.9758 per U.S. dollar, the exchange rate of the Swiss National Bank for the Swiss franc on August 17, 2015.</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0"></TD><TD STYLE="width: 0.25in">(4)</TD><TD>Estimated solely for the purpose of calculating the registration fee pursuant to Rules 457(c) and 457(h)(1) under the Securities
Act, based on the average of the high and low prices reported for the Registrant&rsquo;s Shares on the Finnish Stock Exchange on
August 17, 2015, converted from Euros to U.S. dollars at an exchange rate of $1.11 per Euro, the Euro Foreign Exchange Reference
rate of the European Central Bank for the Euro on such date.</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>


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<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; text-indent: 0.25in">PART I</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; text-indent: 0.25in">INFORMATION REQUIRED
IN THE SECTION 10(a) PROSPECTUS</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">The documents containing the information
specified in Item 1 and Item 2 of Part I of Form S-8 will be sent or given to participants as specified by Rule 428(b)(1) under
the Securities Act. In accordance with the rules and regulations of the U.S. Securities and Exchange Commission (the &ldquo;<B>Commission</B>&rdquo;)
and the instructions to Form S-8, such documents are not being filed with the Commission either as part of this Registration Statement
or as prospectuses or prospectus supplements pursuant to Rule 424 under the Securities Act.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; text-indent: 0.25in">PART II</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; text-indent: 0.25in">INFORMATION REQUIRED
IN THE REGISTRATION STATEMENT</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">Item 3. Incorporation of Documents
by Reference.</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">The following documents are incorporated
herein by reference:</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">(a) The Registrant&rsquo;s prospectus dated
June 10, 2015, filed with the Commission on June 12, 2015, pursuant to Rule 424(b) of the Securities Act, relating to the Registration
Statement on Form F-1, as amended (Registration No. 333-204147), which contains the Registrant&rsquo;s audited financial statements
for the latest fiscal year for which such statements have been filed.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">(b) The description of the Registrant&rsquo;s
share capital which is contained in the Registrant&rsquo;s Securities Exchange Act of 1934 (&ldquo;<B>Exchange Act</B>&rdquo;)
Registration Statement on Form 8-A (Exchange Act File No. 001-37423), dated June 10, 2015, including any amendments or supplements
thereto.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">In addition, all documents subsequently
filed by the Registrant with the Commission pursuant to Sections 13(a), 13(c), 14 and 15(d) of the Exchange Act, prior to the filing
of a post-effective amendment to this Registration Statement which indicates that all securities offered have been sold or which
deregisters all securities then remaining unsold, including any Reports of Foreign Private Issuers on Form 6-K submitted during
such period (or portion thereof) that is identified in such form as being incorporated by reference into this Registration Statement,
shall be deemed to be incorporated by reference in this Registration Statement and to be a part hereof from the date of the filing
of such documents. The Registrant is not incorporating by reference any documents or portions thereof, whether specifically listed
above or filed in the future, that are not deemed &ldquo;filed&rdquo; with the Commission.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">Any statement contained in a document incorporated
or deemed to be incorporated by reference herein shall be deemed to be modified or superseded for purposes of this Registration
Statement to the extent that a statement contained herein, (or in any other subsequently filed document which also is incorporated
or deemed to be incorporated by reference herein), modifies or supersedes such statement. Any such statement so modified or superseded
shall not be deemed, except as so modified or superseded, to constitute a part of this Registration Statement.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">Item 4. Description of Securities.</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">Not applicable. See Item 3(b).</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">Item 5. Interests of Named Experts
and Counsel.</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">Not applicable.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">Item 6. Indemnification of Directors
and Officers.</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 24.5pt">The Registrant&rsquo;s articles of association
contain no provisions under which any member of its board of directors or senior management team members is indemnified in any
manner against any liability which they may incur in their capacity as such. Article 12 of the Registrant&rsquo;s articles of association,
however, provides, amongst other matters, that in the annual general meeting of shareholders &ldquo;the granting of discharge from
liability of the members of the Board of Directors and the Managing Director&rdquo; shall be resolved. The Registrant may
enter into indemnification agreements with its President and Chief Executive Officer and members of the senior management team
that give them the right, to the fullest extent permitted by law, to recover from the Company</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 24.5pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 24.5pt">&nbsp;</P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 24.5pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt; text-indent: 0pt">amounts, including but not limited
to litigation expenses, and any damages they are ordered to pay, in relation to acts or omissions in the performance of their duties.
However, there is generally no entitlement to indemnification for acts or omissions that amount to willful, intentionally reckless
or seriously culpable conduct. In addition to such indemnification, the Registrant provides its senior management team members
and directors with customary directors&rsquo; and officers&rsquo; liability insurance.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 24.5pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 24.5pt">At present, there is no pending material
litigation or proceeding involving the Registrant&rsquo;s directors or officers where indemnification will be required or permitted.
In addition, the Registrant is not aware of any threatened material litigation or proceeding that may result in a claim for such
indemnification.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 24.5pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 24.5pt">Insofar as indemnification of liabilities
arising under the Securities Act may be permitted to directors, management or persons controlling us pursuant to the foregoing
provisions, the Registrant has been informed that, in the opinion of the Commission, such indemnification is against public policy
as expressed in the Securities Act and is therefore unenforceable. &nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 24.5pt">&nbsp;</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">Item 7. Exemption from Registration
Claimed.</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">Not applicable.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">Item 8. Exhibits.</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<table cellspacing="0" cellpadding="0" style="width: 100%; font: 10pt Times New Roman, Times, Serif; border-collapse: collapse">
<tr style="vertical-align: top">
    <TD STYLE="width: 9%">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; border-bottom: Black 0.5pt solid">Exhibit Number&nbsp;</P></td>
    <TD STYLE="width: 1%">&nbsp;</TD>
    <TD STYLE="width: 90%">&nbsp;</td></tr>
<tr style="vertical-align: top">
    <TD><font style="font-size: 10pt">4.1</font></td>
    <TD>&nbsp;</TD>
    <TD><font style="font-size: 10pt">Form of Deposit Agreement (incorporated herein by reference to the Registrant&rsquo;s Registration Statement on Form&nbsp;F-6 (File No.&nbsp;333-204707) dated as of June&nbsp;4, 2015)</font></td></tr>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<tr style="vertical-align: top">
    <TD><font style="font-size: 10pt">4.2</font></td>
    <TD>&nbsp;</TD>
    <TD><font style="font-size: 10pt">Form of Certificate of ADSs of Biotie Therapies Oyj (included in Exhibit 4.1)</font></td></tr>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<tr style="vertical-align: top">
    <TD><font style="font-size: 10pt">4.3</font></td>
    <TD>&nbsp;</TD>
    <TD><font style="font-size: 10pt">English translation of Articles of Association of Biotie Therapies Corp. (incorporated herein by reference to Exhibit 3.1 to the Registrant&rsquo;s Registration Statement on Form F-1, dated as of May 14, 2015 (Registration No. 333-204147))</font></td></tr>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<tr style="vertical-align: top">
    <TD><font style="font-size: 10pt">5.1</font></td>
    <TD>&nbsp;</TD>
    <TD><font style="font-size: 10pt">Opinion of Hannes Snellman Attorneys Ltd, Finnish counsel to Biotie Therapies Oyj, as to the validity of the Shares</font></td></tr>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<tr style="vertical-align: top">
    <TD><font style="font-size: 10pt">23.1</font></td>
    <TD>&nbsp;</TD>
    <TD><font style="font-size: 10pt">Consent of PricewaterhouseCoopers Oy</font></td></tr>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<tr style="vertical-align: top">
    <TD><font style="font-size: 10pt">23.2</font></td>
    <TD>&nbsp;</TD>
    <TD><font style="font-size: 10pt">Consent of Hannes Snellman Attorneys Ltd, Finnish counsel to Biotie Therapies Oyj (included in Exhibit 5.1) </font></td></tr>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<tr style="vertical-align: top">
    <TD><font style="font-size: 10pt">24.1</font></td>
    <TD>&nbsp;</TD>
    <TD><font style="font-size: 10pt">Powers of attorney (included in the signature page to this Registration Statement)</font></td></tr>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<tr>
    <TD STYLE="vertical-align: top"><font style="font-size: 10pt">99.1</font></td>
    <TD>&nbsp;</TD>
    <TD STYLE="vertical-align: bottom"><font style="font-size: 10pt">Biotie Therapies Corp. Stock Option Plan 2011 (incorporated herein by reference to Exhibit 10.2 to the Registrant&rsquo;s Registration Statement on Form F-1, dated as of May 14, 2015 (Registration No. 333-204147))</font></td></tr>
<TR>
    <TD STYLE="vertical-align: top">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD></TR>
<tr>
    <TD STYLE="vertical-align: top"><font style="font-size: 10pt">99.2</font></td>
    <TD>&nbsp;</TD>
    <TD STYLE="vertical-align: bottom"><font style="font-size: 10pt">Biotie Therapies Corp. Equity Incentive Plan 2014 (incorporated herein by reference to Exhibit 10.3 to the Registrant&rsquo;s Registration Statement on Form F-1, dated as of May 14, 2015 (Registration No. 333-204147))</font></td></tr>
<TR>
    <TD STYLE="vertical-align: top">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD></TR>
<tr>
    <TD STYLE="vertical-align: top"><font style="font-size: 10pt">99.3</font></td>
    <TD>&nbsp;</TD>
    <TD STYLE="vertical-align: bottom"><font style="font-size: 10pt">Biotie Therapies Corp. Stock Option Plan 2014 (incorporated herein by reference to Exhibit 10.4 to the Registrant&rsquo;s Registration Statement on Form F-1, dated as of May 14, 2015 (Registration No. 333-204147))</font></td></tr>
<TR>
    <TD STYLE="vertical-align: top">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD></TR>
<tr>
    <TD STYLE="vertical-align: top"><font style="font-size: 10pt">99.4</font></td>
    <TD>&nbsp;</TD>
    <TD STYLE="vertical-align: bottom"><font style="font-size: 10pt">Biotie Therapies AG 2008 Stock Option Incentive Plan</font></td></tr>
</table>
<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

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<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0"></P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">Item 9. Undertakings.</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">(a)&#9;The undersigned Registrant hereby
undertakes:</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.25in; text-indent: 0.25in">(1)&#9;To file, during any period
in which offers or sales are being made, a post-effective amendment to this Registration Statement:</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.25in; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in; text-indent: 0.25in">(i)&#9;To include any prospectus
required by Section 10(a)(3) of the Securities Act;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in; text-indent: 0.25in">(ii)&#9;To reflect in the prospectus
any facts or events arising after the effective date of this Registration Statement (or the most recent post-effective amendment
thereof) which, individually or in the aggregate, represent a fundamental change in the information set forth in this Registration
Statement. Notwithstanding the foregoing, any increase or decrease in volume of securities offered (if the total dollar value of
securities offered would not exceed that which was registered) and any deviation from the low or high end of the estimated maximum
offering range may be reflected in the form of prospectus filed with the Commission pursuant to Rule&nbsp;424(b)&nbsp;if, in the
aggregate, the changes in volume and price represent no more than a 20 percent change in the maximum aggregate offering price set
forth in the &ldquo;Calculation of Registration Fee&rdquo; table in the effective Registration Statement;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in; text-indent: 0.25in">(iii)&#9;To include any material
information with respect to the Plan not previously disclosed in this Registration Statement or any material change to such information
in this Registration Statement;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.25in; text-indent: 0in"><I>provided</I>, <I>however</I>,
that paragraphs (a)(1)(i) and (a)(1)(ii) do not apply if the information required to be included in a post-effective amendment
by those paragraphs is contained in periodic reports filed with or furnished to the Commission by the Registrant pursuant to Section
13 or 15(d) of the Exchange Act that are incorporated by reference in this Registration Statement.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.25in; text-indent: 0in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.25in; text-indent: 0.25in">(2)&#9;That, for the purpose
of determining any liability under the Securities Act, each such post-effective amendment shall be deemed to be a new registration
statement relating to the securities offered therein, and the offering of such securities at that time shall be deemed to be the
initial <I>bona fide</I> offering thereof.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.25in; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.25in; text-indent: 0.25in">(3)&#9;To remove from registration
by means of a post-effective amendment any of the securities being registered which remain unsold at the termination of the offering.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.25in; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">(b)&#9;The undersigned Registrant hereby
undertakes that, for purposes of determining any liability under the Securities Act, each filing of the Registrant&rsquo;s annual
report pursuant to Section 13(a) or 15(d) of the Exchange Act (and, where applicable, each filing of an employee benefit plan&rsquo;s
annual report pursuant to Section 15(d) of the Exchange Act) that is incorporated by reference in this Registration Statement shall
be deemed to be a new registration statement relating to the securities offered therein, and the offering of such securities at
that time shall be deemed to be the initial <I>bona fide</I> offering thereof.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">(c)&#9;Insofar as indemnification for liabilities
arising under the Securities Act may be permitted to directors, officers and controlling persons of the Registrant pursuant to
the foregoing provisions, or otherwise, the Registrant has been advised that in the opinion of the Commission such indemnification
is against public policy as expressed in the Securities Act and is, therefore, unenforceable. In the event that a claim for indemnification
against such liabilities (other than the payment by the Registrant of expenses incurred or paid by a director, officer or controlling
person of the Registrant in the successful defense of any action, suit or proceeding) is asserted by such director, officer or
controlling person in connection with the securities being registered, the Registrant will, unless in the opinion of its counsel
the matter has been settled by controlling precedent, submit to a court of appropriate jurisdiction the question whether such indemnification
by it is against public policy as expressed in the Securities Act and will be governed by the final adjudication of such issue.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>


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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; text-indent: 0in"><B>SIGNATURES</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; text-indent: 0in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">Pursuant to the requirements of the Securities
Act, the Registrant certifies that it has reasonable grounds to believe that it meets all of the requirements for filing this Registration
Statement and has duly caused this Registration Statement to be signed on its behalf by the undersigned, thereunto duly authorized,
in the City of Turku, Finland, on this 20th day of August, 2015.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" ALIGN="RIGHT" STYLE="font: 10pt Times New Roman, Times, Serif; width: 40%; border-collapse: collapse">
<tr style="vertical-align: top">
    <td colspan="2"><font style="font-size: 10pt">BIOTIE THERAPIES OYJ</font></td></tr>
<TR STYLE="vertical-align: top">
    <TD COLSPAN="2">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD COLSPAN="2">&nbsp;</TD></TR>
<tr style="vertical-align: top">
    <TD STYLE="width: 21%"><font style="font-size: 10pt">By:</font></td>
    <TD STYLE="width: 79%; border-bottom: Black 1pt solid"><font style="font-size: 10pt">/s/ Timo Veromaa</font></td></tr>
<tr style="vertical-align: top">
    <td><font style="font-size: 10pt">Name:</font></td>
    <td><font style="font-size: 10pt">Timo Veromaa</font></td></tr>
<tr style="vertical-align: top">
    <td><font style="font-size: 10pt">Title:</font></td>
    <td><font style="font-size: 10pt">President and Chief Executive Officer</font></td></tr>
<tr style="vertical-align: top">
    <td>&nbsp;</td>
    <td>&nbsp;</td></tr>
</table><BR STYLE="clear: both">

<P STYLE="margin-top: 0; margin-bottom: 0">&nbsp;</P>

<P STYLE="margin-top: 0; margin-bottom: 0">&nbsp;</P>

<P STYLE="margin-top: 0; margin-bottom: 0">&nbsp;</P>

<P STYLE="margin-top: 0; margin-bottom: 0"></P>

<P STYLE="margin-top: 0; margin-bottom: 0">&nbsp;</P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>POWER OF ATTORNEY</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in; background-color: white">KNOW ALL PERSONS
BY THESE PRESENTS, that each person whose signature appears below hereby constitutes and appoints Timo Veromaa and David Cook each
of them, individually, as his true and lawful attorneys-in-fact and agents, with full power of substitution and resubstitution,
for him and in his name, place and stead in any and all capacities, in connection with this registration statement, including to
sign in the name and on behalf of the undersigned, this registration statement and any and all amendments thereto, including post-effective
amendments and registrations filed pursuant to Rule 462 under the U.S. Securities Act of 1933, and to file the same, with all exhibits
thereto, and other documents in connection therewith, with the U.S. Securities and Exchange Commission, granting unto such attorneys-in-fact
and agents full power and authority to do and perform each and every act and thing requisite and necessary to be done in and about
the premises, as fully to all intents and purposes as he might or could do in person, hereby ratifying and confirming all that
said attorneys-in-fact and agents, or his substitute, may lawfully do or cause to be done by virtue hereof.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in; background-color: white">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 42.85pt; background-color: white">Pursuant to the
requirements of the Securities Act of 1933, as amended, this registration statement has been signed by the following persons on
August 20, 2015 in the capacities indicated.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 42.85pt; background-color: white">&nbsp;</P>

<table cellspacing="0" cellpadding="0" style="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
<tr style="vertical-align: bottom">
    <td style="width: 46%; text-decoration: underline; text-align: center; font-weight: bold"><font style="font-size: 10pt"><u>Name</u></font></td>
    <td style="width: 54%; text-decoration: underline; text-align: center; font-weight: bold"><font style="font-size: 10pt"><u>Title</u></font></td></tr>
<TR STYLE="vertical-align: bottom">
    <TD STYLE="text-decoration: underline; text-align: center; font-weight: bold">&nbsp;</TD>
    <TD STYLE="text-decoration: underline; text-align: center; font-weight: bold"></TD></TR>
<tr style="vertical-align: bottom">
    <td style="border-bottom: Black 1pt solid; text-align: center">/s/ Timo Veromaa</td>
    <td style="text-align: center">President and Chief Executive Officer<br>
(principal executive officer)</td></tr>
<tr style="vertical-align: top">
    <td style="text-align: center">Timo Veromaa</td>
    <td style="text-align: center">&nbsp;</td></tr>
<tr style="vertical-align: bottom">
    <td style="border-bottom: Black 1pt solid; text-align: center">/s/ David Cook</td>
    <td style="text-align: center">Chief Financial Officer<br>
(principal financial officer and principal accounting officer)</td></tr>
<tr style="vertical-align: top">
    <td style="text-align: center">David Cook</td>
    <td style="text-align: center">&nbsp;</td></tr>
<tr style="vertical-align: bottom">
    <td style="border-bottom: Black 1pt solid; text-align: center">/s/ William M. Burns</td>
    <td style="text-align: center">Chairman of the Board</td></tr>
<tr style="vertical-align: top">
    <td style="text-align: center">William M. Burns</td>
    <td style="text-align: center">&nbsp;</td></tr>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: center">&nbsp;</TD>
    <TD STYLE="text-align: center">&nbsp;</TD></TR>
<tr style="vertical-align: bottom">
    <td style="border-bottom: Black 1pt solid; text-align: center">/s/ Don M. Bailey</td>
    <td style="text-align: center">Director</td></tr>
<tr style="vertical-align: top">
    <td style="text-align: center">Don M. Bailey</td>
    <td style="text-align: center">&nbsp;</td></tr>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: center">&nbsp;</TD>
    <TD STYLE="text-align: center">&nbsp;</TD></TR>
<tr style="vertical-align: bottom">
    <td style="border-bottom: Black 1pt solid; text-align: center">/s/ Merja Karhap&auml;&auml;</td>
    <td style="text-align: center">Director</td></tr>
<tr style="vertical-align: top">
    <td style="text-align: center">Merja Karhap&auml;&auml;</td>
    <td style="text-align: center">&nbsp;</td></tr>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: center">&nbsp;</TD>
    <TD STYLE="text-align: center">&nbsp;</TD></TR>
<tr style="vertical-align: bottom">
    <td style="border-bottom: Black 1pt solid; text-align: center">/s/ Bernd Kastler</td>
    <td style="text-align: center">Director</td></tr>
<tr style="vertical-align: top">
    <td style="text-align: center">Bernd Kastler</td>
    <td style="text-align: center">&nbsp;</td></tr>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: center">&nbsp;</TD>
    <TD STYLE="text-align: center">&nbsp;</TD></TR>
<tr style="vertical-align: bottom">
    <td style="border-bottom: Black 1pt solid; text-align: center">/s/ Ismail Kola</td>
    <td style="text-align: center">Director</td></tr>
<tr style="vertical-align: top">
    <td style="text-align: center">Ismail Kola</td>
    <td style="text-align: center">&nbsp;</td></tr>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: center">&nbsp;</TD>
    <TD STYLE="text-align: center">&nbsp;</TD></TR>
<tr style="vertical-align: bottom">
    <td style="border-bottom: Black 1pt solid; text-align: center">/s/ Guido Magni</td>
    <td style="text-align: center">Director</td></tr>
<tr style="vertical-align: top">
    <td style="text-align: center">Guido Magni</td>
    <td style="text-align: center">&nbsp;</td></tr>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: center">&nbsp;</TD>
    <TD STYLE="text-align: center">&nbsp;</TD></TR>
<tr style="vertical-align: bottom">
    <td style="border-bottom: Black 1pt solid; text-align: center">/s/ Mahendra G. Shah</td>
    <td style="text-align: center">Director</td></tr>
<tr style="vertical-align: top">
    <td style="text-align: center">Mahendra G. Shah</td>
    <td style="text-align: center">&nbsp;</td></tr>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: center">&nbsp;</TD>
    <TD STYLE="text-align: center">&nbsp;</TD></TR>
<tr style="vertical-align: bottom">
    <td style="border-bottom: Black 1pt solid; text-align: center">/s/ Colleen A. De Vries</td>
    <td style="text-align: center">Authorized Representative in the United States</td></tr>
<tr style="vertical-align: top">
    <td>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">Colleen A. De Vries</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"></P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">SVP of National Corporate Research, Ltd</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P></td>
    <td style="text-align: center">&nbsp;</td></tr>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD STYLE="text-align: center">&nbsp;</TD></TR>
</table>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>EXHIBIT INDEX</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<table cellspacing="0" cellpadding="0" style="width: 100%; font: 10pt Times New Roman, Times, Serif; border-collapse: collapse">
<tr style="vertical-align: top">
    <TD STYLE="width: 9%">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; border-bottom: Black 0.5pt solid">Exhibit Number&nbsp;</P></td>
    <TD STYLE="width: 1%">&nbsp;</TD>
    <TD STYLE="width: 90%">&nbsp;</td></tr>
<tr style="vertical-align: top">
    <TD><font style="font-size: 10pt">4.1</font></td>
    <TD>&nbsp;</TD>
    <TD><font style="font-size: 10pt">Form of Deposit Agreement (incorporated herein by reference to the Registrant&rsquo;s Registration Statement on Form&nbsp;F-6 (File No.&nbsp;333-204707) dated as of June&nbsp;4, 2015)</font></td></tr>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<tr style="vertical-align: top">
    <TD><font style="font-size: 10pt">4.2</font></td>
    <TD>&nbsp;</TD>
    <TD><font style="font-size: 10pt">Form of Certificate of ADSs of Biotie Therapies Oyj (included in Exhibit 4.1)</font></td></tr>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<tr style="vertical-align: top">
    <TD><font style="font-size: 10pt">4.3</font></td>
    <TD>&nbsp;</TD>
    <TD><font style="font-size: 10pt">English translation of Articles of Association of Biotie Therapies Corp. (incorporated herein by reference to Exhibit 3.1 to the Registrant&rsquo;s Registration Statement on Form F-1, dated as of May 14, 2015 (Registration No. 333-204147))</font></td></tr>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<tr style="vertical-align: top">
    <TD><font style="font-size: 10pt">5.1</font></td>
    <TD>&nbsp;</TD>
    <TD><font style="font-size: 10pt">Opinion of Hannes Snellman Attorneys Ltd, Finnish counsel to Biotie Therapies Oyj, as to the validity of the Shares</font></td></tr>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<tr style="vertical-align: top">
    <TD><font style="font-size: 10pt">23.1</font></td>
    <TD>&nbsp;</TD>
    <TD><font style="font-size: 10pt">Consent of PricewaterhouseCoopers Oy</font></td></tr>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<tr style="vertical-align: top">
    <TD><font style="font-size: 10pt">23.2</font></td>
    <TD>&nbsp;</TD>
    <TD><font style="font-size: 10pt">Consent of Hannes Snellman Attorneys Ltd, Finnish counsel to Biotie Therapies Oyj (included in Exhibit 5.1) </font></td></tr>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<tr style="vertical-align: top">
    <TD><font style="font-size: 10pt">24.1</font></td>
    <TD>&nbsp;</TD>
    <TD><font style="font-size: 10pt">Powers of attorney (included in the signature page to this Registration Statement)</font></td></tr>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<tr>
    <TD STYLE="vertical-align: top"><font style="font-size: 10pt">99.1</font></td>
    <TD>&nbsp;</TD>
    <TD STYLE="vertical-align: bottom"><font style="font-size: 10pt">Biotie Therapies Corp. Stock Option Plan 2011 (incorporated herein by reference to Exhibit 10.2 to the Registrant&rsquo;s Registration Statement on Form F-1, dated as of May 14, 2015 (Registration No. 333-204147))</font></td></tr>
<TR>
    <TD STYLE="vertical-align: top">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD></TR>
<tr>
    <TD STYLE="vertical-align: top"><font style="font-size: 10pt">99.2</font></td>
    <TD>&nbsp;</TD>
    <TD STYLE="vertical-align: bottom"><font style="font-size: 10pt">Biotie Therapies Corp. Equity Incentive Plan 2014 (incorporated herein by reference to Exhibit 10.3 to the Registrant&rsquo;s Registration Statement on Form F-1, dated as of May 14, 2015 (Registration No. 333-204147))</font></td></tr>
<TR>
    <TD STYLE="vertical-align: top">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD></TR>
<tr>
    <TD STYLE="vertical-align: top"><font style="font-size: 10pt">99.3</font></td>
    <TD>&nbsp;</TD>
    <TD STYLE="vertical-align: bottom"><font style="font-size: 10pt">Biotie Therapies Corp. Stock Option Plan 2014 (incorporated herein by reference to Exhibit 10.4 to the Registrant&rsquo;s Registration Statement on Form F-1, dated as of May 14, 2015 (Registration No. 333-204147))</font></td></tr>
<TR>
    <TD STYLE="vertical-align: top">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD></TR>
<tr>
    <TD STYLE="vertical-align: top"><font style="font-size: 10pt">99.4</font></td>
    <TD>&nbsp;</TD>
    <TD STYLE="vertical-align: bottom"><font style="font-size: 10pt">Biotie Therapies AG 2008 Stock Option Incentive Plan</font></td></tr>
</table>

<P STYLE="margin-top: 0; margin-bottom: 0">&nbsp;</P>

<P STYLE="margin-top: 0; margin-bottom: 0">&nbsp;</P>

<P STYLE="margin-top: 0; margin-bottom: 0">&nbsp;</P>

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[{"type": "S-8", "sequence": "1", "filename": "dp58890_s8.htm", "description": "FORM S-8", "secsgml_size_bytes": 66260}]
{"company-data": {"conformed-name": "Biotie Therapies Corp.", "cik": "0001579695", "assigned-sic": "2834", "irs-number": "000000000", "state-of-incorporation": "H9", "fiscal-year-end": "1231"}, "filing-values": {"form-type": "S-8", "act": "33", "file-number": "333-206484", "film-number": "151066651"}, "business-address": {"street1": "JOUKAHAISENKATU 6", "city": "TURKU", "state": "H9", "zip": "FI-20520", "phone": "358-2-274-8900"}, "mail-address": {"street1": "JOUKAHAISENKATU 6", "city": "TURKU", "state": "H9", "zip": "FI-20520"}}
As filed with the Securities and Exchange
Commission on August 20, 2015
Registration
No. 333-
UNITED STATES
SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM S-8
REGISTRATION STATEMENT
UNDER THE SECURITIES ACT OF 1933
BIOTIE THERAPIES OYJ
(Exact Name of Registrant as specified
in its charter)
Republic of Finland
NOT APPLICABLE
(State or other jurisdiction of
incorporation or organization)
(I.R.S. Employer
Identification No.)
Joukahaisenkatu 6, FI-20520
Turku, Finland
(+358) 2 274-8900
(Address including zip code of Principal Executive Offices)
Biotie Therapies Corp. Stock
Option Plan 2014
Biotie Therapies Corp. Equity
Incentive Plan 2014
Biotie Therapies Corp. Stock
Option Plan 2011
Biotie Therapies AG 2008 Stock
Option Incentive Plan
(Full title of the plans)
Biotie Therapies, Inc.
701 Gateway Boulevard —
Suite 350
South San Francisco, CA 94080
(650) 244-4850
(Name, address and telephone number, including area code, of agent for service)
Copies to:
Jean M. McLoughlin
Sophia Hudson
Davis Polk & Wardwell LLP
450 Lexington Avenue
New York, NY 10017
Indicate by check mark whether the registrant
is a large accelerated filer, an accelerated filer, a non-accelerated filer, or a smaller reporting company. See the definitions
of "large accelerated filer," "accelerated filer" and "smaller reporting company" in Rule 12b-2
of the Exchange Act.
Large accelerated filer
[_]
Accelerated filer
[_]
Non-accelerated filer
[X]
(Do not check if a smaller reporting company)
Smaller reporting company
[_]
CALCULATION OF REGISTRATION FEE
Title of Securities to be Registered
Amount to be
Registered (1)
Proposed Maximum Offering Price Per Share (2)
Proposed Maximum  Aggregate
Offering Price (2)
Amount of
Registration Fee (2)
Shares, no nominal value, reserved for issuance pursuant to the:
—
—
—
—
- Biotie Therapies Corp. Stock Option Plan 2014
8,465,000
$0.01 (3)
$93,961.50
$10.92
- Biotie Therapies Corp. Equity Incentive Plan 2014
14,002,500
$0.24 (4)
$3,326,153.85
$386.50
Shares, no nominal value, reserved for issuance pursuant to share option awards outstanding under the:
—
—
—
—
- Biotie Therapies Corp. Stock Option Plan 2014
1,490,000
$0.01 (3)
$16,539.00
$1.92
- Biotie Therapies Corp. Stock Option Plan 2011
1,957,500
$0.01 (3)
$21,728.25
$2.52
- Biotie Therapies AG 2008 Stock Option Incentive Plan
2,053,134
$0.33 (3)
$673,296.66
$78.24
Total
27,968,134
N/A
$4,131,679.26
$480.10
(1)
This Registration Statement on Form S-8 (this "
Registration Statement
") covers shares, no nominal value,
of Biotie Therapies Oyj (the "
Registrant
") (such shares, the "
Shares
"), which may be represented
by American Depositary Shares, or ADSs, with each ADS representing 80 Shares, issuable pursuant to the plans set forth in this
table (collectively, the "
Plans
"). The Registrant's ADSs issuable upon deposit of the Shares registered
hereby have been registered under a separate registration statement on Form F-6 (File No. 333-204707). Pursuant to Rule 416(a)
under the Securities Act of 1933, as amended (the "
Securities Act
"), this Registration Statement shall also
cover any additional Shares that become issuable under any of the Plans by reason of any share dividend, share split or other similar
transaction.
(2)
Rounded up to the nearest penny.
(3)
Estimated pursuant to Rule 457(h)(1) under the Securities Act, solely for the purpose of computing the registration fee, based
on the weighted average per share exercise price of the options outstanding under the applicable Plan. The exercise prices for
options granted pursuant to the Biotie Therapies Corp. Stock Option Plan 2014 and the Biotie Therapies Corp. Stock Option Plan
2011 have been converted from Euros to U.S. dollars at an exchange rate of $1.11 per Euro, the Euro Foreign Exchange Reference
rate of the European Central Bank for the Euro on August 17, 2015. The exercise prices for options granted pursuant to the Biotie
Therapies AG 2008 Stock Option Incentive Plan have been converted from Swiss francs to U.S. dollars at an exchange rate of CHF
0.9758 per U.S. dollar, the exchange rate of the Swiss National Bank for the Swiss franc on August 17, 2015.
(4)
Estimated solely for the purpose of calculating the registration fee pursuant to Rules 457(c) and 457(h)(1) under the Securities
Act, based on the average of the high and low prices reported for the Registrant's Shares on the Finnish Stock Exchange on
August 17, 2015, converted from Euros to U.S. dollars at an exchange rate of $1.11 per Euro, the Euro Foreign Exchange Reference
rate of the European Central Bank for the Euro on such date.
2
PART I
INFORMATION REQUIRED
IN THE SECTION 10(a) PROSPECTUS
The documents containing the information
specified in Item 1 and Item 2 of Part I of Form S-8 will be sent or given to participants as specified by Rule 428(b)(1) under
the Securities Act. In accordance with the rules and regulations of the U.S. Securities and Exchange Commission (the "
Commission
")
and the instructions to Form S-8, such documents are not being filed with the Commission either as part of this Registration Statement
or as prospectuses or prospectus supplements pursuant to Rule 424 under the Securities Act.
PART II
INFORMATION REQUIRED
IN THE REGISTRATION STATEMENT
Item 3. Incorporation of Documents
by Reference.
The following documents are incorporated
herein by reference:
(a) The Registrant's prospectus dated
June 10, 2015, filed with the Commission on June 12, 2015, pursuant to Rule 424(b) of the Securities Act, relating to the Registration
Statement on Form F-1, as amended (Registration No. 333-204147), which contains the Registrant's audited financial statements
for the latest fiscal year for which such statements have been filed.
(b) The description of the Registrant's
share capital which is contained in the Registrant's Securities Exchange Act of 1934 ("
Exchange Act
")
Registration Statement on Form 8-A (Exchange Act File No. 001-37423), dated June 10, 2015, including any amendments or supplements
thereto.
In addition, all documents subsequently
filed by the Registrant with the Commission pursuant to Sections 13(a), 13(c), 14 and 15(d) of the Exchange Act, prior to the filing
of a post-effective amendment to this Registration Statement which indicates that all securities offered have been sold or which
deregisters all securities then remaining unsold, including any Reports of Foreign Private Issuers on Form 6-K submitted during
such period (or portion thereof) that is identified in such form as being incorporated by reference into this Registration Statement,
shall be deemed to be incorporated by reference in this Registration Statement and to be a part hereof from the date of the filing
of such documents. The Registrant is not incorporating by reference any documents or portions thereof, whether specifically listed
above or filed in the future, that are not deemed "filed" with the Commission.
Any statement contained in a document incorporated
or deemed to be incorporated by reference herein shall be deemed to be modified or superseded for purposes of this Registration
Statement to the extent that a statement contained herein, (or in any other subsequently filed document which also is incorporated
or deemed to be incorporated by reference herein), modifies or supersedes such statement. Any such statement so modified or superseded
shall not be deemed, except as so modified or superseded, to constitute a part of this Registration Statement.
Item 4. Description of Securities.
Not applicable. See Item 3(b).
Item 5. Interests of Named Experts
and Counsel.
Not applicable.
Item 6. Indemnification of Directors
and Officers.
The Registrant's articles of association
contain no provisions under which any member of its board of directors or senior management team members is indemnified in any
manner against any liability which they may incur in their capacity as such. Article 12 of the Registrant's articles of association,
however, provides, amongst other matters, that in the annual general meeting of shareholders "the granting of discharge from
liability of the members of the Board of Directors and the Managing Director" shall be resolved. The Registrant may
enter into indemnification agreements with its President and Chief Executive Officer and members of the senior management team
that give them the right, to the fullest extent permitted by law, to recover from the Company
3
amounts, including but not limited
to litigation expenses, and any damages they are ordered to pay, in relation to acts or omissions in the performance of their duties.
However, there is generally no entitlement to indemnification for acts or omissions that amount to willful, intentionally reckless
or seriously culpable conduct. In addition to such indemnification, the Registrant provides its senior management team members
and directors with customary directors' and officers' liability insurance.
At present, there is no pending material
litigation or proceeding involving the Registrant's directors or officers where indemnification will be required or permitted.
In addition, the Registrant is not aware of any threatened material litigation or proceeding that may result in a claim for such
indemnification.
Insofar as indemnification of liabilities
arising under the Securities Act may be permitted to directors, management or persons controlling us pursuant to the foregoing
provisions, the Registrant has been informed that, in the opinion of the Commission, such indemnification is against public policy
as expressed in the Securities Act and is therefore unenforceable.
Item 7. Exemption from Registration
Claimed.
Not applicable.
Item 8. Exhibits.
Exhibit Number
4.1
Form of Deposit Agreement (incorporated herein by reference to the Registrant's Registration Statement on Form F-6 (File No. 333-204707) dated as of June 4, 2015)
4.2
Form of Certificate of ADSs of Biotie Therapies Oyj (included in Exhibit 4.1)
4.3
English translation of Articles of Association of Biotie Therapies Corp. (incorporated herein by reference to Exhibit 3.1 to the Registrant's Registration Statement on Form F-1, dated as of May 14, 2015 (Registration No. 333-204147))
5.1
Opinion of Hannes Snellman Attorneys Ltd, Finnish counsel to Biotie Therapies Oyj, as to the validity of the Shares
23.1
Consent of PricewaterhouseCoopers Oy
23.2
Consent of Hannes Snellman Attorneys Ltd, Finnish counsel to Biotie Therapies Oyj (included in Exhibit 5.1)
24.1
Powers of attorney (included in the signature page to this Registration Statement)
99.1
Biotie Therapies Corp. Stock Option Plan 2011 (incorporated herein by reference to Exhibit 10.2 to the Registrant's Registration Statement on Form F-1, dated as of May 14, 2015 (Registration No. 333-204147))
99.2
Biotie Therapies Corp. Equity Incentive Plan 2014 (incorporated herein by reference to Exhibit 10.3 to the Registrant's Registration Statement on Form F-1, dated as of May 14, 2015 (Registration No. 333-204147))
99.3
Biotie Therapies Corp. Stock Option Plan 2014 (incorporated herein by reference to Exhibit 10.4 to the Registrant's Registration Statement on Form F-1, dated as of May 14, 2015 (Registration No. 333-204147))
99.4
Biotie Therapies AG 2008 Stock Option Incentive Plan
4
Item 9. Undertakings.
(a)	The undersigned Registrant hereby
undertakes:
(1)	To file, during any period
in which offers or sales are being made, a post-effective amendment to this Registration Statement:
(i)	To include any prospectus
required by Section 10(a)(3) of the Securities Act;
(ii)	To reflect in the prospectus
any facts or events arising after the effective date of this Registration Statement (or the most recent post-effective amendment
thereof) which, individually or in the aggregate, represent a fundamental change in the information set forth in this Registration
Statement. Notwithstanding the foregoing, any increase or decrease in volume of securities offered (if the total dollar value of
securities offered would not exceed that which was registered) and any deviation from the low or high end of the estimated maximum
offering range may be reflected in the form of prospectus filed with the Commission pursuant to Rule 424(b) if, in the
aggregate, the changes in volume and price represent no more than a 20 percent change in the maximum aggregate offering price set
forth in the "Calculation of Registration Fee" table in the effective Registration Statement;
(iii)	To include any material
information with respect to the Plan not previously disclosed in this Registration Statement or any material change to such information
in this Registration Statement;
provided
,
however
,
that paragraphs (a)(1)(i) and (a)(1)(ii) do not apply if the information required to be included in a post-effective amendment
by those paragraphs is contained in periodic reports filed with or furnished to the Commission by the Registrant pursuant to Section
13 or 15(d) of the Exchange Act that are incorporated by reference in this Registration Statement.
(2)	That, for the purpose
of determining any liability under the Securities Act, each such post-effective amendment shall be deemed to be a new registration
statement relating to the securities offered therein, and the offering of such securities at that time shall be deemed to be the
initial
bona fide
offering thereof.
(3)	To remove from registration
by means of a post-effective amendment any of the securities being registered which remain unsold at the termination of the offering.
(b)	The undersigned Registrant hereby
undertakes that, for purposes of determining any liability under the Securities Act, each filing of the Registrant's annual
report pursuant to Section 13(a) or 15(d) of the Exchange Act (and, where applicable, each filing of an employee benefit plan's
annual report pursuant to Section 15(d) of the Exchange Act) that is incorporated by reference in this Registration Statement shall
be deemed to be a new registration statement relating to the securities offered therein, and the offering of such securities at
that time shall be deemed to be the initial
bona fide
offering thereof.
(c)	Insofar as indemnification for liabilities
arising under the Securities Act may be permitted to directors, officers and controlling persons of the Registrant pursuant to
the foregoing provisions, or otherwise, the Registrant has been advised that in the opinion of the Commission such indemnification
is against public policy as expressed in the Securities Act and is, therefore, unenforceable. In the event that a claim for indemnification
against such liabilities (other than the payment by the Registrant of expenses incurred or paid by a director, officer or controlling
person of the Registrant in the successful defense of any action, suit or proceeding) is asserted by such director, officer or
controlling person in connection with the securities being registered, the Registrant will, unless in the opinion of its counsel
the matter has been settled by controlling precedent, submit to a court of appropriate jurisdiction the question whether such indemnification
by it is against public policy as expressed in the Securities Act and will be governed by the final adjudication of such issue.
5
SIGNATURES
Pursuant to the requirements of the Securities
Act, the Registrant certifies that it has reasonable grounds to believe that it meets all of the requirements for filing this Registration
Statement and has duly caused this Registration Statement to be signed on its behalf by the undersigned, thereunto duly authorized,
in the City of Turku, Finland, on this 20th day of August, 2015.
BIOTIE THERAPIES OYJ
By:
/s/ Timo Veromaa
Name:
Timo Veromaa
Title:
President and Chief Executive Officer
6
POWER OF ATTORNEY
KNOW ALL PERSONS
BY THESE PRESENTS, that each person whose signature appears below hereby constitutes and appoints Timo Veromaa and David Cook each
of them, individually, as his true and lawful attorneys-in-fact and agents, with full power of substitution and resubstitution,
for him and in his name, place and stead in any and all capacities, in connection with this registration statement, including to
sign in the name and on behalf of the undersigned, this registration statement and any and all amendments thereto, including post-effective
amendments and registrations filed pursuant to Rule 462 under the U.S. Securities Act of 1933, and to file the same, with all exhibits
thereto, and other documents in connection therewith, with the U.S. Securities and Exchange Commission, granting unto such attorneys-in-fact
and agents full power and authority to do and perform each and every act and thing requisite and necessary to be done in and about
the premises, as fully to all intents and purposes as he might or could do in person, hereby ratifying and confirming all that
said attorneys-in-fact and agents, or his substitute, may lawfully do or cause to be done by virtue hereof.
Pursuant to the
requirements of the Securities Act of 1933, as amended, this registration statement has been signed by the following persons on
August 20, 2015 in the capacities indicated.
Name
Title
/s/ Timo Veromaa
President and Chief Executive Officer
(principal executive officer)
Timo Veromaa
/s/ David Cook
Chief Financial Officer
(principal financial officer and principal accounting officer)
David Cook
/s/ William M. Burns
Chairman of the Board
William M. Burns
/s/ Don M. Bailey
Director
Don M. Bailey
/s/ Merja Karhapää
Director
Merja Karhapää
/s/ Bernd Kastler
Director
Bernd Kastler
/s/ Ismail Kola
Director
Ismail Kola
/s/ Guido Magni
Director
Guido Magni
/s/ Mahendra G. Shah
Director
Mahendra G. Shah
/s/ Colleen A. De Vries
Authorized Representative in the United States
Colleen A. De Vries
SVP of National Corporate Research, Ltd
7
EXHIBIT INDEX
Exhibit Number
4.1
Form of Deposit Agreement (incorporated herein by reference to the Registrant's Registration Statement on Form F-6 (File No. 333-204707) dated as of June 4, 2015)
4.2
Form of Certificate of ADSs of Biotie Therapies Oyj (included in Exhibit 4.1)
4.3
English translation of Articles of Association of Biotie Therapies Corp. (incorporated herein by reference to Exhibit 3.1 to the Registrant's Registration Statement on Form F-1, dated as of May 14, 2015 (Registration No. 333-204147))
5.1
Opinion of Hannes Snellman Attorneys Ltd, Finnish counsel to Biotie Therapies Oyj, as to the validity of the Shares
23.1
Consent of PricewaterhouseCoopers Oy
23.2
Consent of Hannes Snellman Attorneys Ltd, Finnish counsel to Biotie Therapies Oyj (included in Exhibit 5.1)
24.1
Powers of attorney (included in the signature page to this Registration Statement)
99.1
Biotie Therapies Corp. Stock Option Plan 2011 (incorporated herein by reference to Exhibit 10.2 to the Registrant's Registration Statement on Form F-1, dated as of May 14, 2015 (Registration No. 333-204147))
99.2
Biotie Therapies Corp. Equity Incentive Plan 2014 (incorporated herein by reference to Exhibit 10.3 to the Registrant's Registration Statement on Form F-1, dated as of May 14, 2015 (Registration No. 333-204147))
99.3
Biotie Therapies Corp. Stock Option Plan 2014 (incorporated herein by reference to Exhibit 10.4 to the Registrant's Registration Statement on Form F-1, dated as of May 14, 2015 (Registration No. 333-204147))
99.4
Biotie Therapies AG 2008 Stock Option Incentive Plan
8