<PAGE>

As filed with Securities and Exchange Commission on September 27, 2000
                                       Registration No. 333- _____________

================================================================================

                                 UNITED STATES
                      SECURITIES AND EXCHANGE COMMISSION
                            Washington, D.C. 20549

                              ------------------

                                   FORM S-8
                            REGISTRATION STATEMENT
                                     Under
                          THE SECURITIES ACT OF 1933

                              ------------------

                              LUMINEX CORPORATION
             Exact name of registrant as specified in its charter)

               Delaware                           74-2747608
     (State or other jurisdiction           (IRS Employer Identification No.)
    of incorporation or organization)

                  12212 Technology Blvd., Austin, Texas 78727
              (Address of principal executive offices) (Zip Code)

                              ------------------

                              LUMINEX CORPORATION
                         2000 LONG-TERM INCENTIVE PLAN
                           (Full title of the Plans)

                              ------------------

                              Michael L. Bengston
             Executive Vice President, General Counsel and Secretary
                              Luminex Corporation
                          12212 Technology Boulevard
                              Austin, Texas 78727
                    (Name and address of agent for service)
                                (512) 219-8020
         (Telephone number, including area code, of agent for service)

                              ------------------

                        CALCULATION OF REGISTRATION FEE
<TABLE>
<CAPTION>
=========================================================================================================
                              Amount              Proposed               Proposed               Amount of
  Title of Securities         to be           Maximum Offering       Maximum Aggregate        Registration
  to Be Registered         Registered(1)       Price per Share         Offering Price              Fee
  ----------------        ------------         --------------          --------------              ---
  <S>                    <C>                  <C>                    <C>                      <C>

  2000 Long-Term Incentive Plan
  -----------------------------
  Common Stock              110,000 shares     $19.625(2)              $ 2,158,750(2)          $   569.91
  Common Stock            2,489,500 shares     $26.875(3)              $66,905,312(3)          $17,663.00
                                               Aggregate Amount of
                                               Registration Fee                                $18,232.91
---------------------------------------------------------------------------------------------------------
</TABLE>

  (1)     This Registration Statement shall also cover any additional shares of
          Registrant's common stock which become issuable under the 2000 Long-
          Term Incentive Plan with respect to the securities registered
          hereunder by reason of any stock dividend, stock split,
          recapitalization or other similar transaction effected without the
          Registrant's receipt of consideration which results in an increase in
          the number of the outstanding shares of common stock of Luminex
          Corporation.

  (2)     Calculated solely for purposes of this offering under Rule 457(h) of
          the Securities Act of 1933, as amended, and, as to the 110,000 shares
          of common stock purchasable upon exercise of outstanding options under
          the 2000 Long-Term Incentive Plan, based upon the respective average
          price at which such options may be exercised.

  (3)     Calculated solely for purposes of this offering under Rule 457(h) of
          the Securities Act of 1933, on the basis of the average of the high
          and low prices per share of common stock of Luminex Corporation as
          reported on the Nasdaq National Market on September 22, 2000.


<PAGE>

                                    PART I
                         INFORMATION REQUIRED IN THE
                           SECTION 10(a) PROSPECTUS

Item 1. Plan Information

        Information required by Part I of Form S-8 to be contained in the
Section 10(a) prospectus is omitted from this registration statement in
accordance with Rule 428 under the Securities Act of 1933, as amended
("Securities Act"), and the Note to Part I of Form S-8.

Item 2. Registration Information and Employee Plan Annual Information.

        Information required by Part I of Form S-8 to be contained in the
Section 10(a) prospectus is omitted from this registration statement in
accordance with Rule 428 under the Securities Act and the Note to Part I of Form
S-8.

                                   PART II

              Information Required in the Registration Statement

Item 3. Incorporation of Documents by Reference

        Luminex Corporation (the "Registrant") incorporates by reference into
this Registration Statement the following documents previously filed with the
Securities Exchange Commission (the "SEC"):

        (a)    Our Registration Statement No. 333-96317 on Form S-1 filed with
               the SEC on February 7, 2000, together with the amendments filed
               with the SEC on March 13, 2000, March 27, 2000 and March 29,
               2000.


        (b)    (1)  The Registrant's Quarterly Report on Form 10-Q for the
               fiscal quarter ended March 31, 2000;

               (2)  The Registrant's Quarterly Report on Form 10-Q for the
               fiscal quarter ended June 30, 2000.

        (c)    Our Registration Statement No. 000-30109 on Form 8-A filed with
               the SEC on March 27, 2000, in which we describe the terms, rights
               and provisions applicable to our outstanding common stock.

        All reports and definitive proxy or information statements filed under
Section 13(a), 13(c), 14 or 15(d) of the Securities Exchange Act of 1934, after
the date of this Registration Statement and prior to the filing of a post-
effective amendment which indicates that all securities offered under this
Registration Statement have been sold or which deregisters all securities then
remaining unsold, shall be deemed to be incorporated by reference into this
Registration Statement and to be a part of this Registration Statement from the
date of filing of such documents. Any statement contained in a document
incorporated or deemed to be incorporated by reference in this Registration
Statement shall be deemed to be modified or superseded for purposes of this
Registration Statement to the extent that a statement contained in this
Registration Statement or in any subsequently filed document which also is
deemed to be incorporated by reference in this Registration Statement modifies
or supersedes such statement. Any such statement so modified or superseded shall
not be deemed, except as so modified or superseded, to constitute a part of this
Registration Statement.

Item 4. Description of Securities

         Not applicable.

<PAGE>

Item 5.   Interests of Named Experts and Counsel

          The validity of the shares of common stock offered hereby will be
passed upon for us by Thompson & Knight L.L.P., Austin, Texas.

Item 6.   Indemnification of Directors and Officers

          Our certificate provides that, except to the extent prohibited by
Delaware law, our directors shall not be personally liable to us or our
stockholders for monetary damages for breach of their fiduciary duty as
directors.  Under Delaware law, the directors have a fiduciary duty to us which
is not eliminated by this provision of our certificate and, in appropriate
circumstances, equitable remedies such as injunctive or other forms of
non-monetary relief will remain available.  In addition, each director will
continue to be subject to liability under Delaware law for breach of their duty
of loyalty to us or our stockholders; for acts or omissions which are found by
a court of competent jurisdiction to be not in good faith or which involve
intentional misconduct or knowing violations of law; for actions leading to
improper personal benefit to the director; and for payment of dividends or
approval of stock repurchases or redemptions that are prohibited by Delaware
law.  This provision also does not affect the directors' responsibilities under
any other laws, such as the federal securities laws or state or federal
environmental laws.

          Section 145 of the Delaware General Corporation Law allows a
corporation to indemnify its directors and officers and to purchase insurance
with respect to liability arising out of their capacity or status as directors
and officers, provided that the indemnification does not eliminate or limit the
liability of a director for (i) any breach of the director's duty of loyalty to
us or our stockholders, (ii) acts or omissions not in good faith or which
involve intentional misconduct or a knowing violation of law, (iii) unlawful
payments of dividends or unlawful stock purchases or redemptions, and (iv) any
transaction from which the director derived an improper personal benefit.

          Delaware law further provides that the permitted indemnification shall
not be deemed exclusive of any other rights to which the directors and officers
may be entitled under our bylaws, any agreement, a vote of stockholders or
otherwise.  Our certificate eliminates the personal liability of directors to
the fullest extent permitted by Delaware law.  In addition, our certificate
provides that we may fully indemnify any person through bylaw provisions,
agreements with such person, vote of stockholders or disinterested directors or
otherwise, in excess of the indemnification and advancement otherwise permitted
by Section 145 of the Delaware General Corporation Law, subject only to limits
created by applicable Delaware law (statutory or non-statutory), with respect to
action for breach of duty to us, our stockholders or others.

          We have also entered into agreements to indemnify our directors and
executive officers, in addition to the indemnification provided for in our
bylaws. We believe that these provisions and agreements are necessary to attract
and retain qualified directors and executive officers. Our bylaws also permit us
to secure insurance on behalf of any officer, director, employee or other agent
for any liability arising out of his or her actions, regardless of whether
Delaware law would permit indemnification.

Item 7.   Exemption from Registration Claimed

          Not applicable.

Item 8.   Exhibits

Exhibit Number  Exhibit
--------------  -------
4.1*            1996 Stock Option Plan of the Registrant, as amended.

4.2*            Form of Stock Option Agreement of the Registrant.

4.3*            Form of Incentive Stock Option Agreement of the Registrant.

4.4*            2000 Long-Term Incentive Plan of the Registrant.

4.5*            Form of Stock Option Award Agreement of the Registrant.
<PAGE>

5.1       Opinion of Thompson & Knight L.L.P.

23.1      Consent of Ernst & Young LLP, Independent Auditors.

23.2      Consent of Thompson & Knight L.L.P. (included in the Opinion of
          Thompson & Knight L.L.P. filed herewith as Exhibit 5.1.).

24.1      Power of Attorney (included on signature page of this Registration
          Statement).

________________

*         Exhibits 4.1 through 4.5 incorporated by reference to previously filed
          exhibits with the Registrant's Registration Statement on Form S-1
          (Registration No. 333-96317).

Item 9.  Undertakings

The undersigned Registrant hereby undertakes:

     (1)  To file, during any period in which offers or sales are being made, a
post-effective amendment to this Registration Statement:

          (i)    To include any prospectus required by Section 10(a)(3) of the
     Securities Act of 1933;

          (ii)   To reflect in the prospectus any facts or events arising after
     the effective date of this Registration Statement (or the most recent post-
     effective amendment thereof) which, individually or in the aggregate,
     represent a fundamental change in the information set forth in this
     Registration Statement. Notwithstanding the foregoing, any increase or
     decrease in volume of securities offered (if the total dollar value of
     securities offered would not exceed that which was registered) and any
     deviation from the low or high end of the estimated maximum offering range
     may be reflected in the form of prospectus filed with the Commission
     pursuant to Rule 424(b) if, in the aggregate, the changes in volume and
     price represent no more than 20% change in the maximum aggregate offering
     price set forth in the "Calculation of Registration Fee" table in the
     effective registration statement; and

          (iii)  To include any material information with respect to the plan of
     distribution not previously disclosed in this Registration Statement or any
     material change to such information in this Registration Statement;

provided, however, that clauses (1)(i) and (1)(ii) shall not apply if the
information required to be included in a post-effective amendment by those
clauses is contained in periodic reports filed by the Registrant pursuant to
Section 13 or Section 15(d) of the Exchange Act that are incorporated by
reference into this Registration Statement.

     (2)  That, for the purpose of determining any liability under the
Securities Act of 1933, each such post-effective amendment shall be deemed to be
a new registration statement relating to the securities offered therein, and the
offering of such securities at that time shall be deemed to be the initial bona
fide offering thereof; and

     (3)  To remove from registration by means of a post-effective amendment any
of the securities being registered which remain unsold at the termination of the
Luminex Corporation 1996 Stock Option Plan and 2000 Long-Term Incentive Plan.

     (4)  That, for purposes of determining any liability under the Securities
Act of 1933, each filing of the Registrant's annual report pursuant to Section
13(a) or Section 15(d) of the Exchange Act of 1934 that is incorporated by
reference into this Registration Statement shall be deemed to be a new
registration statement relating to the securities offered therein, and the
offering of such securities at that time shall be deemed to be the initial bona
fide offering thereof.
<PAGE>

     (5)  Insofar as indemnification for liabilities arising under the
 Securities Act of 1933 may be permitted to directors, officers or controlling
 persons of the Registrant pursuant to the indemnification provisions summarized
 in Item 6 or otherwise, the Registrant has been advised that, in the opinion of
 the Commission, such indemnification is against public policy as expressed in
 the Securities Act and is, therefore, unenforceable. In the event that a claim
 for indemnification against such liabilities (other than the payment by the
 Registrant of expenses incurred or paid by a director, officer, or controlling
 person of the Registrant in the successful defense of any action, suit or
 proceeding) is asserted by such director, officer or controlling person in
 connection with the securities being registered, the Registrant will, unless in
 the opinion of its counsel the matter has been settled by controlling
 precedent, submit to a court of appropriate jurisdiction the question whether
 such indemnification by it is against public policy as expressed in the 1933
 Act and will be governed by the final adjudication of such issue.


                                  SIGNATURES

     Pursuant to the requirements of the Securities Act of 1933, as amended, the
Registrant certifies that it has reasonable grounds to believe that it meets all
of the requirements for filing on Form S-8, and has duly caused this
Registration Statement to be signed on its behalf by the undersigned, thereunto
duly authorized, in the City of Austin, State of Texas on this 26th day of
September, 2000.


                                         LUMINEX CORPORATION




                                         By: /s/ Mark B. Chandler
                                            ------------------------------------
                                            Mark B. Chandler, Ph.D.
                                            Chairman and Chief Executive Officer


                               POWER OF ATTORNEY
                                  -----------

     KNOW ALL PERSONS BY THESE PRESENTS, that each person whose signature
appears below constitutes and appoints Mark B. Chandler, Chairman and Chief
Executive Officer, and Michael L. Bengtson, Executive Vice President and General
Counsel, and each of them, as such person's true and lawful attorneys-in-fact
and agents, with full power of substitution and resubstitution, for such person
and in such person's name, place and stead, in any and all capacities, to sign
any and all amendments (including post-effective amendments) to this
Registration Statement, and to file same, with all exhibits thereto, and other
documents in connection therewith, with the Securities and Exchange Commission,
granting unto said attorneys-in-fact and agents, and each of them, full power
and authority to do and perform each and every act and thing requisite and
necessary to be done in connection therewith, as fully to all intents and
purposes as such person might or could do in person, hereby ratifying and
confirming all that said attorneys-in-fact and agents, or any of them, or their
or his or her substitutes, may lawfully do or cause to be done by virtue
thereof.

     Pursuant to the requirements of the Securities Act of 1933, as amended,
this Registration Statement has been signed below by the following persons on
behalf of the Registrant, in the capacities and on the dates indicated:

Signature                Title                         Date
---------                -----                         ----

                         Chairman of the Board,
/s/ Mark B. Chandler     President and Chief           September 26, 2000
-----------------------  Executive Officer
Mark B. Chandler, Ph.D.  (Principal Executive
                         Officer)
<PAGE>

/s/ James L. Persky           Vice President and Chief       September 26, 2000
---------------------------   Financial Officer
James L. Persky               (Principal Financial
                              Officer)

/s/ Harriss T. Currie         Controller (Principal          September 26, 2000
---------------------------   Accounting Officer)
Harriss T. Currie

/s/ G. Walter Loewenbaum      Director                       September 26, 2000
---------------------------
G. Walter Loewenbaum

/s/ A. Sidney Alpert          Director                       September 26, 2000
---------------------------
A. Sidney Alpert

/s/ Robert J. Cresci          Director                       September 26, 2000
---------------------------
Robert J. Cresci

/s/ Laurence E. Hirsch        Director                       September 26, 2000
---------------------------
Laurence E. Hirsch

/s/ Jim D. Kever              Director                       September 26, 2000
---------------------------
Jim D. Kever

/s/ Fred C. Goad, Jr.         Director                       September 26, 2000
---------------------------
Fred C. Goad, Jr.

/s/ John E. Koerner, III      Director                       September 26, 2000
---------------------------
John E. Koerner, III

/s/ William L. Roper, Ph.D.   Director                       September 26, 2000
---------------------------
William L. Roper, Ph.D.
<PAGE>

                                 EXHIBIT INDEX

Exhibit Number      Exhibit
--------------      -------
4.1*                1996 Stock Option Plan of the Registrant, as amended.

4.2*                Form of Stock Option Agreement of the Registrant.

4.3*                Form of Incentive Stock Option Agreement of the Registrant.

4.4*                2000 Long-Term Incentive Plan of the Registrant.

4.5*                Form of Stock Option Award Agreement of the Registrant.

5.1                 Opinion of Thompson & Knight L.L.P.

23.1                Consent of Ernst & Young LLP, Independent Auditors.

23.2                Consent of Thompson & Knight L.L.P. (included in the Opinion
                    of Thompson & Knight L.L.P. filed herewith as Exhibit 5.1.).

24.1                Power of Attorney (included on signature page of this
                    Registration Statement).

__________________________

*                   Exhibits 4.1 through 4.5 incorporated by reference to
                    previously filed exhibits with the Registrant's Registration
                    Statement on Form S-1 (Registration No. 333-96317).
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{"company-data": {"conformed-name": "LUMINEX CORP", "cik": "0001033905", "assigned-sic": "8731", "irs-number": "742747608", "state-of-incorporation": "DE", "fiscal-year-end": "1231"}, "filing-values": {"form-type": "S-8", "act": "33", "file-number": "333-46686", "film-number": "729447"}, "business-address": {"street1": "12212 TECHNOLOGY BLVD", "street2": "512-219-8020", "city": "AUSTIN", "state": "TX", "zip": "78727"}, "mail-address": {"street1": "12212 TECHNOLOGY BLVD", "city": "AUSTIN", "state": "TX", "zip": "78727"}}
As filed with Securities and Exchange Commission on September 27, 2000
                                       Registration No. 333- _____________

================================================================================

                                 UNITED STATES
                      SECURITIES AND EXCHANGE COMMISSION
                            Washington, D.C. 20549

                              ------------------

                                   FORM S-8
                            REGISTRATION STATEMENT
                                     Under
                          THE SECURITIES ACT OF 1933

                              ------------------

                              LUMINEX CORPORATION
             Exact name of registrant as specified in its charter)

               Delaware                           74-2747608
     (State or other jurisdiction           (IRS Employer Identification No.)
    of incorporation or organization)

                  12212 Technology Blvd., Austin, Texas 78727
              (Address of principal executive offices) (Zip Code)

                              ------------------

                              LUMINEX CORPORATION
                         2000 LONG-TERM INCENTIVE PLAN
                           (Full title of the Plans)

                              ------------------

                              Michael L. Bengston
             Executive Vice President, General Counsel and Secretary
                              Luminex Corporation
                          12212 Technology Boulevard
                              Austin, Texas 78727
                    (Name and address of agent for service)
                                (512) 219-8020
         (Telephone number, including area code, of agent for service)

                              ------------------

                        CALCULATION OF REGISTRATION FEE
=========================================================================================================
                              Amount              Proposed               Proposed               Amount of
  Title of Securities         to be           Maximum Offering       Maximum Aggregate        Registration
  to Be Registered         Registered(1)       Price per Share         Offering Price              Fee
  ----------------        ------------         --------------          --------------              ---
2000 Long-Term Incentive Plan
  -----------------------------
  Common Stock              110,000 shares     $19.625(2)              $ 2,158,750(2)          $   569.91
  Common Stock            2,489,500 shares     $26.875(3)              $66,905,312(3)          $17,663.00
                                               Aggregate Amount of
                                               Registration Fee                                $18,232.91
---------------------------------------------------------------------------------------------------------
(1)     This Registration Statement shall also cover any additional shares of
          Registrant's common stock which become issuable under the 2000 Long-
          Term Incentive Plan with respect to the securities registered
          hereunder by reason of any stock dividend, stock split,
          recapitalization or other similar transaction effected without the
          Registrant's receipt of consideration which results in an increase in
          the number of the outstanding shares of common stock of Luminex
          Corporation.

  (2)     Calculated solely for purposes of this offering under Rule 457(h) of
          the Securities Act of 1933, as amended, and, as to the 110,000 shares
          of common stock purchasable upon exercise of outstanding options under
          the 2000 Long-Term Incentive Plan, based upon the respective average
          price at which such options may be exercised.

  (3)     Calculated solely for purposes of this offering under Rule 457(h) of
          the Securities Act of 1933, on the basis of the average of the high
          and low prices per share of common stock of Luminex Corporation as
          reported on the Nasdaq National Market on September 22, 2000.
PART I
                         INFORMATION REQUIRED IN THE
                           SECTION 10(a) PROSPECTUS

Item 1. Plan Information

        Information required by Part I of Form S-8 to be contained in the
Section 10(a) prospectus is omitted from this registration statement in
accordance with Rule 428 under the Securities Act of 1933, as amended
("Securities Act"), and the Note to Part I of Form S-8.

Item 2. Registration Information and Employee Plan Annual Information.

        Information required by Part I of Form S-8 to be contained in the
Section 10(a) prospectus is omitted from this registration statement in
accordance with Rule 428 under the Securities Act and the Note to Part I of Form
S-8.

                                   PART II

              Information Required in the Registration Statement

Item 3. Incorporation of Documents by Reference

        Luminex Corporation (the "Registrant") incorporates by reference into
this Registration Statement the following documents previously filed with the
Securities Exchange Commission (the "SEC"):

        (a)    Our Registration Statement No. 333-96317 on Form S-1 filed with
               the SEC on February 7, 2000, together with the amendments filed
               with the SEC on March 13, 2000, March 27, 2000 and March 29,
               2000.

        (b)    (1)  The Registrant's Quarterly Report on Form 10-Q for the
               fiscal quarter ended March 31, 2000;

               (2)  The Registrant's Quarterly Report on Form 10-Q for the
               fiscal quarter ended June 30, 2000.

        (c)    Our Registration Statement No. 000-30109 on Form 8-A filed with
               the SEC on March 27, 2000, in which we describe the terms, rights
               and provisions applicable to our outstanding common stock.

        All reports and definitive proxy or information statements filed under
Section 13(a), 13(c), 14 or 15(d) of the Securities Exchange Act of 1934, after
the date of this Registration Statement and prior to the filing of a post-
effective amendment which indicates that all securities offered under this
Registration Statement have been sold or which deregisters all securities then
remaining unsold, shall be deemed to be incorporated by reference into this
Registration Statement and to be a part of this Registration Statement from the
date of filing of such documents. Any statement contained in a document
incorporated or deemed to be incorporated by reference in this Registration
Statement shall be deemed to be modified or superseded for purposes of this
Registration Statement to the extent that a statement contained in this
Registration Statement or in any subsequently filed document which also is
deemed to be incorporated by reference in this Registration Statement modifies
or supersedes such statement. Any such statement so modified or superseded shall
not be deemed, except as so modified or superseded, to constitute a part of this
Registration Statement.

Item 4. Description of Securities

         Not applicable.
Item 5.   Interests of Named Experts and Counsel

          The validity of the shares of common stock offered hereby will be
passed upon for us by Thompson & Knight L.L.P., Austin, Texas.

Item 6.   Indemnification of Directors and Officers

          Our certificate provides that, except to the extent prohibited by
Delaware law, our directors shall not be personally liable to us or our
stockholders for monetary damages for breach of their fiduciary duty as
directors.  Under Delaware law, the directors have a fiduciary duty to us which
is not eliminated by this provision of our certificate and, in appropriate
circumstances, equitable remedies such as injunctive or other forms of
non-monetary relief will remain available.  In addition, each director will
continue to be subject to liability under Delaware law for breach of their duty
of loyalty to us or our stockholders; for acts or omissions which are found by
a court of competent jurisdiction to be not in good faith or which involve
intentional misconduct or knowing violations of law; for actions leading to
improper personal benefit to the director; and for payment of dividends or
approval of stock repurchases or redemptions that are prohibited by Delaware
law.  This provision also does not affect the directors' responsibilities under
any other laws, such as the federal securities laws or state or federal
environmental laws.

          Section 145 of the Delaware General Corporation Law allows a
corporation to indemnify its directors and officers and to purchase insurance
with respect to liability arising out of their capacity or status as directors
and officers, provided that the indemnification does not eliminate or limit the
liability of a director for (i) any breach of the director's duty of loyalty to
us or our stockholders, (ii) acts or omissions not in good faith or which
involve intentional misconduct or a knowing violation of law, (iii) unlawful
payments of dividends or unlawful stock purchases or redemptions, and (iv) any
transaction from which the director derived an improper personal benefit.

          Delaware law further provides that the permitted indemnification shall
not be deemed exclusive of any other rights to which the directors and officers
may be entitled under our bylaws, any agreement, a vote of stockholders or
otherwise.  Our certificate eliminates the personal liability of directors to
the fullest extent permitted by Delaware law.  In addition, our certificate
provides that we may fully indemnify any person through bylaw provisions,
agreements with such person, vote of stockholders or disinterested directors or
otherwise, in excess of the indemnification and advancement otherwise permitted
by Section 145 of the Delaware General Corporation Law, subject only to limits
created by applicable Delaware law (statutory or non-statutory), with respect to
action for breach of duty to us, our stockholders or others.

          We have also entered into agreements to indemnify our directors and
executive officers, in addition to the indemnification provided for in our
bylaws. We believe that these provisions and agreements are necessary to attract
and retain qualified directors and executive officers. Our bylaws also permit us
to secure insurance on behalf of any officer, director, employee or other agent
for any liability arising out of his or her actions, regardless of whether
Delaware law would permit indemnification.

Item 7.   Exemption from Registration Claimed

          Not applicable.

Item 8.   Exhibits

Exhibit Number  Exhibit
--------------  -------
4.1*            1996 Stock Option Plan of the Registrant, as amended.

4.2*            Form of Stock Option Agreement of the Registrant.

4.3*            Form of Incentive Stock Option Agreement of the Registrant.

4.4*            2000 Long-Term Incentive Plan of the Registrant.

4.5*            Form of Stock Option Award Agreement of the Registrant.
5.1       Opinion of Thompson & Knight L.L.P.

23.1      Consent of Ernst & Young LLP, Independent Auditors.

23.2      Consent of Thompson & Knight L.L.P. (included in the Opinion of
          Thompson & Knight L.L.P. filed herewith as Exhibit 5.1.).

24.1      Power of Attorney (included on signature page of this Registration
          Statement).

________________

*         Exhibits 4.1 through 4.5 incorporated by reference to previously filed
          exhibits with the Registrant's Registration Statement on Form S-1
          (Registration No. 333-96317).

Item 9.  Undertakings

The undersigned Registrant hereby undertakes:

     (1)  To file, during any period in which offers or sales are being made, a
post-effective amendment to this Registration Statement:

          (i)    To include any prospectus required by Section 10(a)(3) of the
     Securities Act of 1933;

          (ii)   To reflect in the prospectus any facts or events arising after
     the effective date of this Registration Statement (or the most recent post-
     effective amendment thereof) which, individually or in the aggregate,
     represent a fundamental change in the information set forth in this
     Registration Statement. Notwithstanding the foregoing, any increase or
     decrease in volume of securities offered (if the total dollar value of
     securities offered would not exceed that which was registered) and any
     deviation from the low or high end of the estimated maximum offering range
     may be reflected in the form of prospectus filed with the Commission
     pursuant to Rule 424(b) if, in the aggregate, the changes in volume and
     price represent no more than 20% change in the maximum aggregate offering
     price set forth in the "Calculation of Registration Fee" table in the
     effective registration statement; and

          (iii)  To include any material information with respect to the plan of
     distribution not previously disclosed in this Registration Statement or any
     material change to such information in this Registration Statement;

provided, however, that clauses (1)(i) and (1)(ii) shall not apply if the
information required to be included in a post-effective amendment by those
clauses is contained in periodic reports filed by the Registrant pursuant to
Section 13 or Section 15(d) of the Exchange Act that are incorporated by
reference into this Registration Statement.

     (2)  That, for the purpose of determining any liability under the
Securities Act of 1933, each such post-effective amendment shall be deemed to be
a new registration statement relating to the securities offered therein, and the
offering of such securities at that time shall be deemed to be the initial bona
fide offering thereof; and

     (3)  To remove from registration by means of a post-effective amendment any
of the securities being registered which remain unsold at the termination of the
Luminex Corporation 1996 Stock Option Plan and 2000 Long-Term Incentive Plan.

     (4)  That, for purposes of determining any liability under the Securities
Act of 1933, each filing of the Registrant's annual report pursuant to Section
13(a) or Section 15(d) of the Exchange Act of 1934 that is incorporated by
reference into this Registration Statement shall be deemed to be a new
registration statement relating to the securities offered therein, and the
offering of such securities at that time shall be deemed to be the initial bona
fide offering thereof.
(5)  Insofar as indemnification for liabilities arising under the
 Securities Act of 1933 may be permitted to directors, officers or controlling
 persons of the Registrant pursuant to the indemnification provisions summarized
 in Item 6 or otherwise, the Registrant has been advised that, in the opinion of
 the Commission, such indemnification is against public policy as expressed in
 the Securities Act and is, therefore, unenforceable. In the event that a claim
 for indemnification against such liabilities (other than the payment by the
 Registrant of expenses incurred or paid by a director, officer, or controlling
 person of the Registrant in the successful defense of any action, suit or
 proceeding) is asserted by such director, officer or controlling person in
 connection with the securities being registered, the Registrant will, unless in
 the opinion of its counsel the matter has been settled by controlling
 precedent, submit to a court of appropriate jurisdiction the question whether
 such indemnification by it is against public policy as expressed in the 1933
 Act and will be governed by the final adjudication of such issue.

                                  SIGNATURES

     Pursuant to the requirements of the Securities Act of 1933, as amended, the
Registrant certifies that it has reasonable grounds to believe that it meets all
of the requirements for filing on Form S-8, and has duly caused this
Registration Statement to be signed on its behalf by the undersigned, thereunto
duly authorized, in the City of Austin, State of Texas on this 26th day of
September, 2000.

                                         LUMINEX CORPORATION

                                         By: /s/ Mark B. Chandler
                                            ------------------------------------
                                            Mark B. Chandler, Ph.D.
                                            Chairman and Chief Executive Officer

                               POWER OF ATTORNEY
                                  -----------

     KNOW ALL PERSONS BY THESE PRESENTS, that each person whose signature
appears below constitutes and appoints Mark B. Chandler, Chairman and Chief
Executive Officer, and Michael L. Bengtson, Executive Vice President and General
Counsel, and each of them, as such person's true and lawful attorneys-in-fact
and agents, with full power of substitution and resubstitution, for such person
and in such person's name, place and stead, in any and all capacities, to sign
any and all amendments (including post-effective amendments) to this
Registration Statement, and to file same, with all exhibits thereto, and other
documents in connection therewith, with the Securities and Exchange Commission,
granting unto said attorneys-in-fact and agents, and each of them, full power
and authority to do and perform each and every act and thing requisite and
necessary to be done in connection therewith, as fully to all intents and
purposes as such person might or could do in person, hereby ratifying and
confirming all that said attorneys-in-fact and agents, or any of them, or their
or his or her substitutes, may lawfully do or cause to be done by virtue
thereof.

     Pursuant to the requirements of the Securities Act of 1933, as amended,
this Registration Statement has been signed below by the following persons on
behalf of the Registrant, in the capacities and on the dates indicated:

Signature                Title                         Date
---------                -----                         ----

                         Chairman of the Board,
/s/ Mark B. Chandler     President and Chief           September 26, 2000
-----------------------  Executive Officer
Mark B. Chandler, Ph.D.  (Principal Executive
                         Officer)
/s/ James L. Persky           Vice President and Chief       September 26, 2000
---------------------------   Financial Officer
James L. Persky               (Principal Financial
                              Officer)

/s/ Harriss T. Currie         Controller (Principal          September 26, 2000
---------------------------   Accounting Officer)
Harriss T. Currie

/s/ G. Walter Loewenbaum      Director                       September 26, 2000
---------------------------
G. Walter Loewenbaum

/s/ A. Sidney Alpert          Director                       September 26, 2000
---------------------------
A. Sidney Alpert

/s/ Robert J. Cresci          Director                       September 26, 2000
---------------------------
Robert J. Cresci

/s/ Laurence E. Hirsch        Director                       September 26, 2000
---------------------------
Laurence E. Hirsch

/s/ Jim D. Kever              Director                       September 26, 2000
---------------------------
Jim D. Kever

/s/ Fred C. Goad, Jr.         Director                       September 26, 2000
---------------------------
Fred C. Goad, Jr.

/s/ John E. Koerner, III      Director                       September 26, 2000
---------------------------
John E. Koerner, III

/s/ William L. Roper, Ph.D.   Director                       September 26, 2000
---------------------------
William L. Roper, Ph.D.
EXHIBIT INDEX

Exhibit Number      Exhibit
--------------      -------
4.1*                1996 Stock Option Plan of the Registrant, as amended.

4.2*                Form of Stock Option Agreement of the Registrant.

4.3*                Form of Incentive Stock Option Agreement of the Registrant.

4.4*                2000 Long-Term Incentive Plan of the Registrant.

4.5*                Form of Stock Option Award Agreement of the Registrant.

5.1                 Opinion of Thompson & Knight L.L.P.

23.1                Consent of Ernst & Young LLP, Independent Auditors.

23.2                Consent of Thompson & Knight L.L.P. (included in the Opinion
                    of Thompson & Knight L.L.P. filed herewith as Exhibit 5.1.).

24.1                Power of Attorney (included on signature page of this
                    Registration Statement).

__________________________

*                   Exhibits 4.1 through 4.5 incorporated by reference to
                    previously filed exhibits with the Registrant's Registration
                    Statement on Form S-1 (Registration No. 333-96317).