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   <TITLE>S-8</TITLE>
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    <td align="center"><strong><font size=2 face="serif">As filed with the Securities
          and Exchange Commission on <B><FONT size=2 face="serif">October 20,
          2004</FONT></B></font></strong></td>
  </tr>
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    <td align="right"> <strong><font size=2 face="serif">Registration No. 333-_____</font></strong></td>
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<strong><FONT size=4 face="serif"><B><FONT size=4 face="serif">UNITED STATES </FONT></B> <br>
SECURITIES AND EXCHANGE COMMISSION</FONT></strong>
<br>
<font size="4"><strong><FONT face="serif">Washington, D.C. 20549</FONT></strong></font>
<br>
<br>
<hr align=center width=15% size=1 noshade color="#000000">
<br>
<strong><FONT size=4 face="serif">FORM S-8<br>
</FONT><br>
<FONT size=3 face="serif">REGISTRATION STATEMENT UNDER THE<br>
SECURITIES ACT OF 1933</FONT></strong>
<br>
<br>
<hr align=center width=15% size=1 noshade color="#000000">
<br>
<B><FONT size=4 face="serif">CHARLES RIVER LABORATORIES<br>
</FONT></B><font size="4"><B><FONT face="serif">INTERNATIONAL, INC.</FONT></B></font><br>
<font size="2"><strong><FONT face="serif">(Exact Name of Registrant as Specified
in Its Charter)<br>
</FONT></strong></font><br>
  <TABLE width="80%" border=0 cellspacing=0 cellpadding=0>
    <TR align="center">
      <TD width="50%"><B><FONT size=2 face="serif">Delaware</FONT></B></TD>
      <TD width="50%"><B><FONT size=2 face="serif">06-1397316</FONT></B></TD>
    </TR>
    <TR align="center" valign="top">
      <TD width="50%"><strong><FONT size=2 face="serif">(State of
      Incorporation)</FONT></strong></TD>
      <TD width="50%"><strong><FONT size=2 face="serif">(I.R.S. Employer<br>
      Identification No.)</FONT></strong></TD>
    </TR>
    <TR align="center" valign="top">
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
    </TR>
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    <td align="center"><strong> <B><FONT size="2" face="serif">251 Ballardvale St., Wilmington,
      MA 01887</FONT></B></strong></td>
  </tr>
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    <td align="center"><B><FONT size=2 face="serif">(Address of Principal Executive
      Offices, Including Zip Code)</FONT></B></td>
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    <td align="center"><hr align=center width=15% size=1 noshade color="#000000"></td>
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    <td align="center"><font size="2"><strong><B><FONT face="serif">Inveresk Research Group,
            Inc. 2002 Stock Option and Incentive<br>
Compensation Plan<br>
Inveresk Research Group, Inc. 2002 Non-Employee Directors Stock Option Plan<br>
(Full Title of the Plans)</FONT></B> </strong></font></td>
  </tr>
  <tr>
    <td align="center"><hr align=center width=15% size=1 noshade color="#000000"></td>
  </tr>
  <tr>
    <td align="center"> <strong><B><FONT size="2" face="serif">Dennis R. Shaughnessy<br>
Senior Vice President<br>
and General Counsel<br>
    </FONT></B><font size="2"><B><FONT face="serif">Charles River Laboratories International,
    Inc.<br>
    251 Ballardvale St.<br>
Wilmington, MA 01887<br>
    (Name and Address of Agent for Service) </FONT></B> </font></strong></td>
  </tr>
  <tr>
    <td align="center">&nbsp;</td>
  </tr>
  <tr>
    <td align="center"><P align="center"> <B><FONT size="2" face="serif">(978)
            658-6000<br>
    </FONT></B><font size="2"><B><FONT face="serif">Telephone Number, Including
    Area Code, of Agent For Service</FONT></B></font></P></td>
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    <td align="center"><hr align=center width=15% size=1 noshade color="#000000"></td>
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<br>
<strong><FONT size=2 face="serif">CALCULATION OF REGISTRATION FEE</FONT></strong></div>
<TABLE width="100%" border=1 cellspacing=2 cellpadding=2>
<TR valign="bottom">
   <TD width="40%" align="center">&nbsp;&nbsp;&nbsp;<strong><FONT size=1 face="serif">Title
         of Securities To Be Registered</FONT></strong></TD>
   <TD width="15%" align="center"><strong><FONT size=1 face="serif">Amount To
         Be<br>
    Registered(1)</FONT></strong></TD>
   <TD width="15%" align="center"><strong><FONT size=1 face="serif">Proposed Maximum<br>
    Offering Price Per<br>
    Share</FONT></strong></TD>
   <TD width="15%" align="center"><strong><FONT size=1 face="serif">Proposed Maximum<br>
    Aggregate Offering<br>
    Price</FONT></strong></TD>
   <TD width="15%" align="center"><strong><FONT size=1 face="serif">Amount of<br>
    Registration Fee</FONT></strong></TD>
  </TR>
<TR valign="bottom">
   <TD width="40%"><FONT size=2 face="serif">Common Stock, $0.01 par value per
    share</FONT></TD>
   <TD width="15%" align="center"><font size="2" face="serif">1,476,658<sup>(4)</sup></font></TD>
   <TD width="15%" align="center"><FONT size=2 face="serif">$19.07<sup>(2)</sup></FONT></TD>
   <TD width="15%" align="center"><FONT size=2 face="serif">$28,159,868.07<sup>(2)</sup></FONT></TD>
   <TD width="15%" align="center"><FONT size=2 face="serif">$3,567.86</FONT></TD>
  </TR>
<TR valign="bottom">
  <TD><FONT size=2 face="serif">Common Stock, $0.01 par value per share</FONT></TD>
  <TD align="center"><FONT size=2 face="serif">1,539,324<sup>(5)</sup></FONT></TD>
  <TD align="center"><FONT size=2 face="serif">$46.29<sup>(3)</sup></FONT></TD>
  <TD align="center"><FONT size=2 face="serif">$71,255,307.96<sup>(3)</sup></FONT></TD>
  <TD align="center"><FONT size=2 face="serif">$9,028.05</FONT></TD>
</TR>
</TABLE>
<table width="100%" border="0" cellspacing="4" cellpadding="0">
  <tr align="left" valign="top">
    <td width="5%"><font size=2 face="serif">(1)</font></td>
    <td width="95%"><FONT size="2" face="serif">This Registration Statement shall
        also cover any additional shares of Registrant&#146;s common stock that
        may be offered to prevent dilution by reason of any stock dividend, stock
    split, recapitalization or other similar transactions.</FONT></td>
  </tr>
  <tr align="left" valign="top">
    <td width="5%"><font size=2 face="serif">(2)</font></td>
    <td width="95%"><FONT size="2" face="serif">Estimated solely for the purpose
        of computing the registration fee of options granted and outstanding
        pursuant to Rule 457(h) under the Securities Act of 1933, based on a
    weighted average exercise price of $19.07.</FONT></td>
  </tr>
  <tr align="left" valign="top">
    <td><font size="2" face="serif">(3) </font></td>
    <td> <FONT size="2" face="serif">Estimated solely for the purpose of
        computing the registration fee pursuant to Rule 457(c) and (h) under
        the Securities Act of 1933, as amended, based on the average of the high
        ($46.67) and low ($45.90) prices of the Registrant&#146;s Common Stock,
        $0.01 par value per share, reported on the New York Stock Exchange on
    October 13, 2004. </FONT></td>
  </tr>
  <tr align="left" valign="top">
    <td><font size="2" face="serif">(4) </font></td>
    <td> <FONT size="2" face="serif">Represents shares subject to issuance
        upon the exercise of outstanding stock options under the Inveresk Research
        Group, Inc. 2002 Stock Option and Incentive Compensation Plan (amended
        and restated as of May 4, 2004) and the Inveresk Research Group, Inc.
        2002 Non-Employee Directors Stock Option Plan (collectively, the &#147;Inveresk
        Plans&#148;) and assumed by Registrant on October 20, 2004 in connection
        with the merger described in the Explanatory Note on the following page
    of this Registration Statement.</FONT> </td>
  </tr>
  <tr align="left" valign="top">
    <td><font size="2" face="serif">(5) </font></td>
    <td> <FONT size="2" face="serif">Represents shares registered for issuance,
        previously issuable under the Employee Plan, adjusted to reflect the
        terms of the merger described in the Explanatory Note on the following
    page of this Registration Statement. </FONT> </td>
  </tr>
</table>
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<P align="center">
<B><FONT size="2" face="serif">EXPLANATORY NOTE </FONT></B>
</P>
<P>
  <FONT size="2" face="serif"> &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Pursuant to
  the Agreement and Plan of Merger dated as of June 30, 2004, by and among Charles
  River Laboratories International, Inc. (the &#147;Registrant&#148;), Inveresk
  Research Group, Inc. (&#147;Inveresk&#148;), Indigo
Merger I Corp. and Indigo Merger II LLC (&#147;Merger Sub II&#148;) (as successor
to Indigo Merger II Corp.), as amended by Amendment No. 1, dated as of September
15, 2004 (as so amended, the &#147;Merger Agreement&#148;), on October 20, 2004
 Indigo Merger I Corp., a wholly owned subsidiary of the Registrant, merged with
and into Inveresk, with Inveresk continuing as the initial surviving corporation,
and immediately thereafter, the initial surviving corporation merged with and
into  Merger Sub II, a wholly owned subsidiary of the Registrant, with Merger
Sub II (renamed Inveresk Research Group, LLC) continuing as the surviving company.
The shares of Registant&#146;s
common stock registered are issuable pursuant to options granted under the Inveresk
Plans or reserved for future issuance. </FONT>
</P>
<P align="center">
  <font size="2"><B><FONT face="serif">Part II. Information Required in the Registration Statement </FONT></B>
  </font></P>
<P>
  <font size="2"><B><FONT face="serif">Item 3: Incorporation of Documents by Reference </FONT></B>
  </font></P>
<P>
  <FONT size="2" face="serif">We hereby incorporate by reference into this Registration
  Statement the following documents previously filed with the Securities and
  Exchange Commission (the &#147;Commission&#148;) pursuant to the Securities Exchange Act of 1934,
as amended (the &#147;Exchange Act&#148;): </FONT>
</P>
<P>
  <font size="2">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<FONT face="serif">(a) The Registrant&#146;s
  annual report on Form 10-K for the fiscal year ended December 27, 2003; </FONT></font>
</P>
<P>
  <font size="2">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<FONT face="serif">(b) All reports
  filed by the Registrant pursuant to Section 13(a) or 15(d) of the Exchange
  Act since December 27, 2003, the end of the fiscal year convened by the Registrant&#146;s
  annual report referred to in (a); and </FONT></font>
</P>
<P>
  <font size="2">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<FONT face="serif">(c) The description
  of the Registrant&#146;s Common Stock, $0.01 par value per share, contained in the Registrant&#146;s
  Registration Statement on Form S-1 dated June 23, 2000, filed pursuant to Section
  12 of the Exchange Act (No. 333-35524), including any amendment or report filed
  for the purpose of updating such description. </FONT></font>
</P>
<P>
  <font size="2">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<FONT face="serif">All other documents
  filed by the Registrant with the Commission pursuant to Sections 13(a), 13(c),
  14 and 15(d) of the Exchange Act subsequent to the date of this Registration
  Statement and prior to the filing of a post-effective amendment to this Registration
  Statement which indicate that all securities offered have been sold or which
  de-register all securities then remaining unsold, shall be deemed to be incorporated
  by reference in this Registration Statement and to be a part hereof from the
  date of filing such documents (such documents, and the documents enumerated
  above, being hereinafter referred to collectively as the &#147;Incorporated Documents&#148;). </FONT></font>
</P>
<div align="center"><font size="2">2</font><font size="2"><br>
  <br>
</font>
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<P>
  <font size="2">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<FONT face="serif">Any statement contained in an Incorporated Document shall be deemed to be modified or superseded for purposes of this Registration Statement to the extent that a statement contained herein or in any
other subsequently filed Incorporated Document modifies or supersedes such statement. Any such statements so modified or superseded shall not be deemed, except as so modified or superseded, to constitute a part of this Registration Statement.
  </FONT></font>
</P>
<P>
  <font size="2"><B><FONT face="serif">Item 4. Description of Securities </FONT></B>
  </font></P>
<P>
  <FONT size="2" face="serif">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Not applicable. </FONT>
</P>
<P>
  <font size="2"><B><FONT face="serif">Item 5. Interest of Named Experts and Counsel </FONT></B>
  </font></P>
<P>
  <font size="2">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<FONT face="serif">Dennis R. Shaughnessy,
  who has issued the opinion of the Registrant&#146;s law department on the legality of the Common Stock of the Registrant offered hereby, is Senior Vice President, Corporate
Development, General Counsel and Secretary of the Registrant. Mr. Shaughnessy owns the Registrant&#146;s Common Stock and holds employee stock options to purchase the Registrant&#146;s
Common Stock. </FONT></font>
</P>
<P>
  <font size="2"><B><FONT face="serif">Item 6. Indemnification of Directors and Officers </FONT></B>
  </font></P>
<P>
  <font size="2">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<FONT face="serif">Section 102
  of the Delaware General Corporation Law (the &#147;DGCL&#148;) allows a corporation to eliminate or limit the personal liability of directors of a corporation to the corporation or its
stockholders for monetary damages for a breach of fiduciary duty as a director, except where the director breached his duty of loyalty, failed to act in good faith, engaged in intentional misconduct or knowingly violated a law, authorized the
payment of a dividend or approved a stock repurchase in violation of Delaware corporate law or obtained an improper personal benefit. Article ELEVENTH of the Registrant&#146;s Amended and Restated Certificate of Incorporation includes such a
provision. Furthermore, Article ELEVENTH of the Registrant&#146;s Amended and
Restated Certificate of Incorporation provides that if the DGCL is amended to
further eliminate or limit the personal liability of directors, then the liability
of a director of the Registrant shall be eliminated or limited to the fullest
extent permitted by the DGCL, as so amended. </FONT></font>
</P>
<P>
  <font size="2">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<FONT face="serif">Section 145
  of the DGCL provides that a corporation has the power to indemnify a director,
  officer, employee or agent of the corporation and certain other persons serving
  at the request of the corporation in related capacities against amounts paid
  and expenses incurred in connection with an action, suit or proceeding (including
  attorneys&#146; fees, judgments, fines and amounts paid in settlement in connection
  with specified actions, suits or proceedings) to which he is or is threatened
  to be made a party by reason of such position, if such person shall have acted
  in good faith and in a manner he reasonably believed to be in or not opposed
  to the best interests of the corporation, and, with respect to any criminal
  proceeding, if such person had no reasonable cause to believe his </FONT></font>
</P>
<div align="center"><font size="2">3</font><font size="2"><br>
  <br>
</font>
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<P>
  <FONT size="2" face="serif">conduct was unlawful; provided that, in the case of actions brought by or in the right of the corporation, no indemnification shall be made with respect to any matter as to which such person shall have been adjudged to be liable
to the corporation unless and only to the extent that the adjudicating court determines that such indemnification is proper under the circumstances. </FONT>
</P>
<P>
  <font size="2">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<FONT face="serif">Article SIXTH
  of the Registrant&#146;s Amended and Restated Certificate of Incorporation
  provides the Registrant (i) may indemnify any persons whom it shall have power
  to indemnify thereunder from and against any and all of the expenses, liabilities
  or other matters referred to in or covered thereby, (ii) shall indemnify each
  such person if he or she is or is threatened to be made a party to any threatened,
  pending or completed action, suit or proceeding by reason of the fact that
  he or she is or was a director, officer or employee of the Registrant or because
  he or she was serving the Registrant or any other legal entity in any capacity
  at the request of the Registrant while a director, officer or employee of the
  Registrant and (iii) shall pay the expense of such a current or former director,
  officer or employee incurred in connection with any such action, suit or proceeding
  in advance of the final disposition of such action, suit or proceeding. The
  indemnification and advancement of expenses provided for herein shall not be
  deemed exclusive of any other rights to which those entitled to indemnification
  or advancement of expenses may be entitled under any by-law, agreement, contract
  or vote of stockholders or disinterested directors or pursuant to the direction
  (however embodied) of any count of competent jurisdiction or otherwise, both
  as to action in his or her official capacity and as to action in another capacity
  while holding such office, and shall continue as to a person who has ceased
  to be a director, officer or employee and shall inure to the benefit of the
  heirs, executors and administrators of such a person. </FONT></font>
</P>
<P>
  <font size="2"><B><FONT face="serif">Item 7. Exemption from Registration Claimed.</FONT></B> </font>
</P>
<P>
  <FONT size="2" face="serif">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Not applicable. </FONT>
</P>
<P>
  <font size="2"><B><FONT face="serif">Item 8. Exhibits.</FONT></B> </font>
</P>
<P align="left">
  <FONT size="2" face="serif">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;The following exhibits are filed as part of this Registration Statement: </FONT>
</P>
<TABLE width="100%" border=0 cellspacing=0 cellpadding=0>
<TR>
   <TD align="left" width="10%"><u><FONT size="2" face="serif">Exhibit No.</FONT></u></TD>
   <TD align="center" width="87%"><u><FONT size="2" face="serif">Description of Documents</FONT></u></TD>
   <TD width="3%">&nbsp;</TD>
</TR>
<TR>
  <TD align="left">&nbsp;</TD>
  <TD width="87%">&nbsp;</TD>
  <TD>&nbsp;</TD>
</TR>
<TR>
   <TD align="left" width="10%"><FONT size="2" face="serif">4.1**</FONT></TD>
   <TD width="87%"><FONT size="2" face="serif">Form of certificate representing
       shares of common stock, $0.01 par value per share.</FONT></TD>
   <TD width="3%">&nbsp;</TD>
</TR>
<TR>
   <TD width="10%" align="left">&nbsp;</TD>
   <TD width="87%">&nbsp;</TD>
   <TD width="3%">&nbsp;</TD>
</TR>
<TR>
   <TD align="left" width="10%"><FONT size="2" face="serif">4.2**</FONT></TD>
   <TD width="87%"><FONT size="2" face="serif">Amended and Restated Certificate
       of Incorporation of Charles River Laboratories International, Inc.</FONT></TD>
   <TD width="3%">&nbsp;</TD>
</TR>
<TR>
   <TD width="10%" align="left">&nbsp;</TD>
   <TD width="87%">&nbsp;</TD>
   <TD width="3%">&nbsp;</TD>
</TR>
<TR>
   <TD align="left" width="10%"><FONT size="2" face="serif">4.3**</FONT></TD>
   <TD width="87%"><FONT size="2" face="serif">Amended and Restated By-laws of
       Charles River Laboratories International, Inc.</FONT></TD>
   <TD width="3%">&nbsp;</TD>
</TR>
<TR>
   <TD width="10%" align="left">&nbsp;</TD>
   <TD width="87%">&nbsp;</TD>
   <TD width="3%">&nbsp;</TD>
</TR>
<TR>
   <TD align="left" width="10%"><FONT size="2" face="serif">5.1*</FONT></TD>
   <TD width="87%"><FONT size="2" face="serif">Opinion of Dennis R. Shaughnessy, Esq.</FONT></TD>
   <TD width="3%">&nbsp;</TD>
</TR>
<TR>
  <TD align="left">&nbsp;</TD>
  <TD>&nbsp;</TD>
  <TD>&nbsp;</TD>
</TR>
<TR>
   <TD align="left" width="10%"><FONT size="2" face="serif">23.1*</FONT></TD>
   <TD width="87%"><FONT size="2" face="serif">Consent of Dennis R. Shaughnessy, Esq. (included in Exhibit 5.1).</FONT></TD>
   <TD width="3%">&nbsp;</TD>
</TR>
</TABLE>

<p align="center"><font size="2" face="serif">4</font><font size="2"><br>
  <br>
  </font></p>
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<TABLE width="100%" border=0 cellspacing=0 cellpadding=0>
<TR>
   <TD align="left" width="10%"><FONT size="2" face="serif">23.2*</FONT></TD>
   <TD width="87%"><FONT size="2" face="serif">Consent of PricewaterhouseCoopers LLP.</FONT></TD>
   <TD width="3%">&nbsp;</TD>
</TR>
<TR>
  <TD align="left">&nbsp;</TD>
  <TD width="87%">&nbsp;</TD>
  <TD width="3%">&nbsp;</TD>
</TR>
<TR>
   <TD align="left" width="10%"><FONT size="2" face="serif">23.3*</FONT></TD>
   <TD width="87%"><FONT size="2" face="serif">Consent of Deloitte &amp; Touche
    LLP.</FONT></TD>
   <TD width="3%">&nbsp;</TD>
</TR>
<TR>
  <TD align="left">&nbsp;</TD>
  <TD width="87%">&nbsp;</TD>
  <TD width="3%">&nbsp;</TD>
</TR>
<TR>
   <TD align="left" width="10%"><FONT size="2" face="serif">24.1*</FONT></TD>
   <TD width="87%"><FONT size="2" face="serif">Power of Attorney (included in
    the signature page of this Registration Statement)</FONT></TD>
   <TD width="3%">&nbsp;</TD>
</TR>
<TR>
   <TD width="10%" align="left">&nbsp;</TD>
   <TD width="87%">&nbsp;</TD>
   <TD width="3%">&nbsp;</TD>
</TR>
<TR>
   <TD align="left" width="10%"><FONT size="2" face="serif">99.1*</FONT></TD>
   <TD width="87%"><FONT size="2" face="serif">Inveresk Research Group, Inc.
       2002 Stock Option and Incentive Compensation Plan (Amended and Restated
    as of May 4, 2004).</FONT></TD>
   <TD width="3%">&nbsp;</TD>
</TR>
<TR>
  <TD align="left">&nbsp;</TD>
  <TD width="87%">&nbsp;</TD>
  <TD width="3%">&nbsp;</TD>
</TR>
<TR>
   <TD align="left" width="10%"><FONT size="2" face="serif">99.2*</FONT></TD>
   <TD width="87%"><FONT size="2" face="serif">Inveresk Research Group, Inc.
    2002 Non-Employee Directors Stock Option Plan.</FONT></TD>
   <TD width="3%">&nbsp;</TD>
</TR>
</TABLE>
<table width="100%" border="0" cellspacing="0" cellpadding="0">
  <tr align="left" valign="top">
    <td colspan="2"><hr align="left" width="10%" size=1 noshade color=GRAY></td>
  </tr>
  <tr align="left" valign="top">
    <td width="3%"><font size="2" face="serif">*</font><font size="2">&nbsp;</font></td>
    <td width="97%"><font size="2"><font face="serif">Filed
    herewith. </font></font> </td>
  </tr>
  <tr align="left" valign="top">
    <td width="3%"><font size="2" face="serif">**</font><font size="2">&nbsp;<font face="serif"></font></font></td>
    <td width="97%"> <font size="2"><font face="serif">Previously
          filed as an exhibit to Amendment No. 2 to the Registrant&#146;s Registration
          Statement on Form S-1 (File No. 333-35524), filed June 23, 2000 and
    incorporated by reference herein. </font></font> </td>
  </tr>
</table>

<P><font size="2"><B><FONT face="serif">Item 9. Undertakings </FONT></B>
</font></P>
<P>
  <FONT size="2" face="serif">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;A. The undersigned Registrant hereby undertakes: </FONT>
</P>
<P>
  <font size="2">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<FONT face="serif">(1) to file, during any period in which offers or sales are being made, a post-effective amendment to this Registration Statement: </FONT></font>
</P>
<blockquote>
  <p>
    <font size="2">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<FONT face="serif">(i) to include
    any prospectus required by Section 10(a)(3) of the Securities Act of 1933,
    as amended (the &#147;Securities Act&#148;); </FONT></font>
  </p>
  <p>
    <font size="2">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<FONT face="serif">(ii) to reflect
    in the prospectus any facts or events arising after the effective date of the
    Registration Statement (or the most recent post-effective amendment thereof)
    which, individually or in the aggregate, represent a fundamental change in
    the information set forth in the Registration Statement. Notwithstanding the
    foregoing, any increase or decrease in volume of securities offered (if the
    total dollar value of securities offered would not exceed that which was registered)
    and any deviation from the low or high end of the estimated maximum offering
    range may be reflected in the form of prospectus filed with the Commission
    pursuant to Rule 424(b) if, in the aggregate, the changes in volume and price
    represent no more than a 20% change in the maximum aggregate offering price
    set forth in the &#147;Calculation of Registration Fee&#148; table in the effective
    Registration Statement; and </FONT></font>
  </p>
  <p>
    <font size="2">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<FONT face="serif">(iii) to
    include any material information with respect to the plan of distribution
    not previously disclosed in the Registration Statement or any material change
    to such information in the Registration  Statement; provided, however, that
    clauses (1)(i) and (1)(ii) shall not apply if the information required to
    be included in a post-effective amendment by those clauses is contained in
    periodic reports filed by the Registrant pursuant to Section 13(a)</FONT></font>
  </p>
</blockquote>
<div align="center">5</div>
<font size="2"><br>
<br>
</font>
<hr size=3 color=GRAY noshade>
<font size="2">
<!-- *************************************************************************** -->
<!-- MARKER PAGE -->
<br>
<br>
</font>
<blockquote>
  <p>
      <FONT size="2" face="serif">or Section 15(d) of the Exchange Act that are incorporated by reference into the Registration Statement; </FONT>
  </p>
</blockquote>
<P>
  <font size="2">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<FONT face="serif">(2) that, for the purpose of determining any liability under the Securities Act, each such post-effective amendment shall be deemed to be a new registration statement relating to the securities
offered therein and the offering of such securities at that time shall be deemed to be the initial<I> bona fide</I> offering thereof; and </FONT></font>
</P>
<P>
  <font size="2">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<FONT face="serif">(3) to remove from registration by means of a post-effective amendment any of the securities being registered which remain unsold at the termination of the offering. </FONT></font>
</P>
<P>
  <font size="2">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<FONT face="serif">B. The undersigned
  Registrant hereby undertakes that, for purposes of determining any liability
  under the Securities Act, each filing of the Registrant&#146;s annual report
  pursuant to Section 13(a) or Section 15(d) of the Exchange Act that is incorporated
  by reference in this Registration Statement shall be deemed to be a new registration
  statement relating to the securities offered therein, and the offering of such
  securities at that time shall be deemed to be the initial <I>bona fide</I> offering thereof. </FONT></font>
</P>
<P>
  <font size="2">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<FONT face="serif">C. Insofar as indemnification for liabilities arising under the Securities Act may be permitted to directors, officers and controlling persons of the Registrant pursuant to the indemnification
provisions summarized in Item 6 or otherwise, the Registrant has been advised that in the opinion of the Commission, such indemnification is against public policy as expressed in the Securities Act and is, therefore, unenforceable. In the event that
a claim for indemnification against such liabilities (other than the payment by the Registrant of expenses incurred or paid by a director, officer, or controlling person of the Registrant in the successful defense of any action, suit or proceeding)
is asserted by such director, officer or controlling person in connection with the securities being registered, the Registrant will, unless in the opinion of its counsel the matter has been settled by controlling precedent, submit to a court of
appropriate jurisdiction the question whether such indemnification by it is against public policy as expressed in the Securities Act and will be governed by the final adjudication of such issue. </FONT></font>
</P>
<P align="center">
<font size="2" face="serif">6</font></P>

<font size="2"><br>
<br>
</font>
<hr size=3 color=GRAY noshade>
<font size="2">
<!-- *************************************************************************** -->
<!-- MARKER PAGE -->
<br>
<br>
</font>
<P align="center">
  <font size="2"><B><FONT face="serif">SIGNATURES </FONT></B>
  </font></P>
<P align="left">
  <font size="2">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<FONT face="serif">Pursuant to the requirements of the Securities Act, the Registrant certifies that it has reasonable grounds to believe that it meets all of the requirements for filing on Form S-8 and has duly caused
this Registration Statement to be signed on its behalf by the undersigned, thereunto duly authorized, in the Town of Wilmington, Commonwealth of Massachusetts, as of the 20th day of
October 2004. </FONT></font></P>
<div align="right">
  <table width="50%" border="0" cellspacing="0" cellpadding="0">
    <tr>
      <td colspan="2"><FONT size="2" face="serif">CHARLES RIVER LABORATORIES<br>
      INTERNATIONAL,INC.</FONT></td>
    </tr>
    <tr>
      <td width="6%"><font size="2" face="Times New Roman, Times, serif">&nbsp;</font></td>
      <td width="94%"><font size="2" face="Times New Roman, Times, serif">&nbsp;</font></td>
    </tr>
    <tr>
      <td width="6%"><font size="2" face="Times New Roman, Times, serif">By:</font></td>
      <td width="94%"><font size="2">/s/ James C. Foster</font> </td>
    </tr>
    <tr>
      <td>&nbsp;</td>
      <td>
        <hr align="left" width="60%" size="1" noshade
color="#000000"></td>
    </tr>
    <tr>
      <td>&nbsp;</td>
      <td><font size="2">James C. Foster</font> </td>
    </tr>
    <tr>
      <td>&nbsp;</td>
      <td><FONT size="2" face="serif">Chairman, Chief Executive Officer<br>
and President</FONT></td>
    </tr>
  </table>
</div>
<P align="center"><br>
<font size="2" face="serif">7</font><font size="2"><br>
<br>
</font></P>
<hr size=3 color=GRAY noshade>
<font size="2">
<!-- *************************************************************************** -->
<!-- MARKER PAGE -->
<br>
<br>
<br>
</font>
<P align="center">
  <font size="2"><B><FONT face="serif">POWER OF ATTORNEY AND SIGNATURES </FONT></B>
  </font></P>
<P>   <FONT size="2" face="serif">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;We, the undersigned officers and directors of Charles River Laboratories International, Inc., hereby severally constitute and appoint James C. Foster, Dennis R. Shaughnessy and Thomas F. Ackerman
and each of them singly, as true and lawful attorneys-in-fact, with full power of substitution, to sign for us in our names in the capacities indicated below, all additional amendments (including post-effective amendments), together with any
exhibits thereto or documents therewith, to this Registration Statement, and generally to do all things in our names and on our behalf in such capacities to enable Charles River Laboratories International, Inc. to comply with the provisions of the
Securities Act, and all applicable requirements of the Commission. </FONT>
</P>
<P>
  <font size="2">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<FONT face="serif">Pursuant to the requirements of the Securities Act, this Registration Statement on Form S-8 has been signed by the following persons in the capacities indicated on October 20, 2004. </FONT></font>
</P>
<TABLE width="95%" border=0 cellspacing=0 cellpadding=0>
<TR>
   <TD width="25%" align="center"><font size="2"><FONT face="serif"><u>Signature</u></FONT></font></TD>
   <TD align="left" width="50%"><FONT size="2" face="serif"><u>Title</u></FONT></TD>
   <TD align="center" width="25%">&nbsp;</TD>
</TR>
<TR>
  <TD>&nbsp;</TD>
  <TD>&nbsp;</TD>
  <TD>&nbsp;</TD>
</TR>
<TR>
   <TD width="25%"><FONT size="2" face="serif">/s/ James C. Foster</FONT></TD>
   <TD width="50%">&nbsp;</TD>
   <TD width="25%">&nbsp;</TD>
</TR>
<TR>
   <TD width="25%"><hr align="left" width="95%" size=1 noshade color=GRAY></TD>
   <TD width="50%"><FONT size="2" face="serif">Chairman, President, Chief Executive Officer and</FONT></TD>
   <TD width="25%">&nbsp;</TD>
</TR>
<TR>
   <TD width="25%"><FONT size="2" face="serif">James C. Foster</FONT></TD>
   <TD width="50%"><FONT size="2" face="serif">Director (Principal Executive Officer)</FONT></TD>
   <TD width="25%">&nbsp;</TD>
</TR>
<TR>
  <TD>&nbsp;</TD>
  <TD>&nbsp;</TD>
  <TD>&nbsp;</TD>
</TR>
<TR>
   <TD width="25%"><FONT size="2" face="serif">/s/ Thomas A. Ackerman</FONT></TD>
   <TD width="50%">&nbsp;</TD>
   <TD width="25%">&nbsp;</TD>
</TR>
<TR>
   <TD width="25%"><hr align="left" width="95%" size=1 noshade color=GRAY></TD>
   <TD width="50%"><FONT size="2" face="serif">Senior Vice President of Finance and Chief Financial</FONT></TD>
   <TD width="25%">&nbsp;</TD>
</TR>
<TR>
   <TD width="25%"><FONT size="2" face="serif">Thomas A. Ackerman</FONT></TD>
   <TD width="50%"><FONT size="2" face="serif">Officer (Principal Financial and Accounting Officer)</FONT></TD>
   <TD width="25%">&nbsp;</TD>
</TR>
<TR>
   <TD width="25%">&nbsp;</TD>
   <TD width="50%">&nbsp;</TD>
   <TD width="25%">&nbsp;</TD>
</TR>
<TR>
  <TD><FONT size="2" face="serif">/s/ Robert Cawthorn</FONT></TD>
  <TD>&nbsp;</TD>
  <TD>&nbsp;</TD>
</TR>
<TR>
   <TD width="25%"><hr align="left" width="95%" size=1 noshade color=GRAY></TD>
   <TD width="50%"><FONT size="2" face="serif">Director</FONT></TD>
   <TD width="25%">&nbsp;</TD>
</TR>
<TR>
   <TD width="25%"><FONT size="2" face="serif">Robert Cawthorn</FONT></TD>
   <TD width="50%">&nbsp;</TD>
   <TD width="25%">&nbsp;</TD>
</TR>
<TR>
  <TD>&nbsp;</TD>
  <TD>&nbsp;</TD>
  <TD>&nbsp;</TD>
</TR>
<TR>
   <TD width="25%"><FONT size="2" face="serif">/s/ Stephen D. Chubb</FONT></TD>
   <TD width="50%">&nbsp;</TD>
   <TD width="25%">&nbsp;</TD>
</TR>
<TR>
   <TD width="25%"><hr align="left" width="95%" size=1 noshade color=GRAY></TD>
   <TD width="50%"><FONT size="2" face="serif">Director</FONT></TD>
   <TD width="25%">&nbsp;</TD>
</TR>
<TR>
   <TD width="25%"><FONT size="2" face="serif">Stephen D. Chubb</FONT></TD>
   <TD width="50%">&nbsp;</TD>
   <TD width="25%">&nbsp;</TD>
</TR>
<TR>
  <TD>&nbsp;</TD>
  <TD>&nbsp;</TD>
  <TD>&nbsp;</TD>
</TR>
<TR>
   <TD width="25%"><FONT size="2" face="serif">/s/ George E. Massaro</FONT></TD>
   <TD width="50%">&nbsp;</TD>
   <TD width="25%">&nbsp;</TD>
</TR>
<TR>
   <TD width="25%"><hr align="left" width="95%" size=1 noshade color=GRAY></TD>
   <TD width="50%"><FONT size="2" face="serif">Director</FONT></TD>
   <TD width="25%">&nbsp;</TD>
</TR>
<TR>
   <TD width="25%"><FONT size="2" face="serif">George E. Massaro</FONT></TD>
   <TD width="50%">&nbsp;</TD>
   <TD width="25%">&nbsp;</TD>
</TR>
<TR>
  <TD>&nbsp;</TD>
  <TD>&nbsp;</TD>
  <TD>&nbsp;</TD>
</TR>
<TR>
   <TD width="25%"><FONT size="2" face="serif">/s/ Linda McGoldrick</FONT></TD>
   <TD width="50%">&nbsp;</TD>
   <TD width="25%">&nbsp;</TD>
</TR>
<TR>
   <TD width="25%"><hr align="left" width="95%" size=1 noshade color=GRAY></TD>
   <TD width="50%"><FONT size="2" face="serif">Director</FONT></TD>
   <TD width="25%">&nbsp;</TD>
</TR>
<TR>
   <TD width="25%"><FONT size="2" face="serif">Linda McGoldrick</FONT></TD>
   <TD width="50%">&nbsp;</TD>
   <TD width="25%">&nbsp;</TD>
</TR>
</TABLE>
<P align="center">
<font size="2" face="serif">8</font></P>

<font size="2"><br>
<br>
</font>
<hr size=3 color=GRAY noshade>
<font size="2">
<!-- *************************************************************************** -->
<!-- MARKER PAGE -->
<br>
<br>
<br>
<br>
</font>
<TABLE width="95%" border=0 cellspacing=0 cellpadding=0>
<TR>
  <TD><FONT size="2" face="serif">/s/ George M. Milne</FONT></TD>
  <TD>&nbsp;</TD>
  <TD>&nbsp;</TD>
</TR>
<TR>
   <TD width="25%"><hr align="left" width="95%" size=1 noshade color=GRAY></TD>
   <TD width="50%"><FONT size="2" face="serif">Director</FONT></TD>
   <TD width="25%">&nbsp;</TD>
</TR>
<TR>
   <TD width="25%"><FONT size="2" face="serif">George M. Milne</FONT></TD>
   <TD width="50%">&nbsp;</TD>
   <TD width="25%">&nbsp;</TD>
</TR>
<TR>
  <TD>&nbsp;</TD>
  <TD>&nbsp;</TD>
  <TD>&nbsp;</TD>
</TR>
<TR>
   <TD width="25%"><FONT size="2" face="serif">/s/ Douglas E. Rogers</FONT></TD>
   <TD width="50%">&nbsp;</TD>
   <TD width="25%">&nbsp;</TD>
</TR>
<TR>
   <TD width="25%"><hr align="left" width="95%" size=1 noshade color=GRAY></TD>
   <TD width="50%"><FONT size="2" face="serif">Director</FONT></TD>
   <TD width="25%">&nbsp;</TD>
</TR>
<TR>
   <TD width="25%"><FONT size="2" face="serif">Douglas E. Rogers</FONT></TD>
   <TD width="50%">&nbsp;</TD>
   <TD width="25%">&nbsp;</TD>
</TR>
<TR>
  <TD>&nbsp;</TD>
  <TD>&nbsp;</TD>
  <TD>&nbsp;</TD>
</TR>
<TR>
   <TD width="25%"><FONT size="2" face="serif">/s/ Samuel O. Thier</FONT></TD>
   <TD width="50%">&nbsp;</TD>
   <TD width="25%">&nbsp;</TD>
</TR>
<TR>
   <TD width="25%"><hr align="left" width="95%" size=1 noshade color=GRAY></TD>
   <TD width="50%"><FONT size="2" face="serif">Director</FONT></TD>
   <TD width="25%">&nbsp;</TD>
</TR>
<TR>
   <TD width="25%"><FONT size="2" face="serif">Samuel O. Thier</FONT></TD>
   <TD width="50%">&nbsp;</TD>
   <TD width="25%">&nbsp;</TD>
</TR>
<TR>
  <TD>&nbsp;</TD>
  <TD>&nbsp;</TD>
  <TD>&nbsp;</TD>
</TR>
<TR>
   <TD width="25%"><FONT size="2" face="serif">/s/ William H. Waltrip</FONT></TD>
   <TD width="50%">&nbsp;</TD>
   <TD width="25%">&nbsp;</TD>
</TR>
<TR>
   <TD width="25%"><hr align="left" width="95%" size=1 noshade color=GRAY></TD>
   <TD width="50%"><FONT size="2" face="serif">Director</FONT></TD>
   <TD width="25%">&nbsp;</TD>
</TR>
<TR>
   <TD width="25%"><FONT size="2" face="serif">William H. Waltrip</FONT></TD>
   <TD width="50%">&nbsp;</TD>
   <TD width="25%">&nbsp;</TD>
</TR>
</TABLE>
<P align="center">
  <font size="2" face="serif">9</font></P>

<font size="2"><br>
<br>
</font>
<hr size=3 color=GRAY noshade>
<font size="2">
<!-- *************************************************************************** -->
<!-- MARKER PAGE -->
<br>
<br>
</font>
<P align="center">
  <font size="2"><B><FONT face="serif">Exhibit Index </FONT></B></font></P>
<TABLE width="100%" border=0 cellspacing=0 cellpadding=0>
<TR>
   <TD align="left" width="10%"><u><FONT size="2" face="serif">Exhibit No.</FONT></u></TD>
   <TD align="center" width="80%"><u><FONT size="2" face="serif">Description of Documents</FONT></u></TD>
   <TD width="10%">&nbsp;</TD>
</TR>
<TR>
  <TD align="left">&nbsp;</TD>
  <TD width="80%">&nbsp;</TD>
  <TD width="10%">&nbsp;</TD>
</TR>
<TR>
   <TD align="left" width="10%"><FONT size="2" face="serif">4.1**</FONT></TD>
   <TD width="80%"><FONT size="2" face="serif">Form of certificate representing
       shares of common stock, $0.01 par value per share.</FONT></TD>
   <TD width="10%">&nbsp;</TD>
</TR>
<TR>
   <TD width="10%" align="left">&nbsp;</TD>
   <TD width="80%">&nbsp;</TD>
   <TD width="10%">&nbsp;</TD>
</TR>
<TR>
   <TD align="left" width="10%"><FONT size="2" face="serif">4.2**</FONT></TD>
   <TD width="80%"><FONT size="2" face="serif">Amended and Restated Certificate
       of Incorporation of Charles River Laboratories International, Inc.</FONT></TD>
   <TD width="10%">&nbsp;</TD>
</TR>
<TR>
   <TD width="10%" align="left">&nbsp;</TD>
   <TD width="80%">&nbsp;</TD>
   <TD width="10%">&nbsp;</TD>
</TR>
<TR>
   <TD align="left" width="10%"><FONT size="2" face="serif">4.3**</FONT></TD>
   <TD width="80%"><FONT size="2" face="serif">Amended and Restated By-laws of
       Charles River Laboratories International, Inc.</FONT></TD>
   <TD width="10%">&nbsp;</TD>
</TR>
<TR>
   <TD width="10%" align="left">&nbsp;</TD>
   <TD width="80%">&nbsp;</TD>
   <TD width="10%">&nbsp;</TD>
</TR>
<TR>
   <TD align="left" width="10%"><FONT size="2" face="serif">5.1*</FONT></TD>
   <TD width="80%"><FONT size="2" face="serif">Opinion of Dennis R. Shaughnessy, Esq.</FONT></TD>
   <TD width="10%">&nbsp;</TD>
</TR>
<TR>
  <TD align="left">&nbsp;</TD>
  <TD width="80%">&nbsp;</TD>
  <TD width="10%">&nbsp;</TD>
</TR>
<TR>
   <TD align="left" width="10%"><FONT size="2" face="serif">23.1*</FONT></TD>
   <TD width="80%"><FONT size="2" face="serif">Consent of Dennis R. Shaughnessy, Esq. (included in Exhibit 5.1).</FONT></TD>
   <TD width="10%">&nbsp;</TD>
</TR>
<TR>
  <TD align="left">&nbsp;</TD>
  <TD>&nbsp;</TD>
  <TD>&nbsp;</TD>
</TR>
<TR>
   <TD align="left" width="10%"><FONT size="2" face="serif">23.2*</FONT></TD>
   <TD width="80%"><FONT size="2" face="serif">Consent of PricewaterhouseCoopers LLP.</FONT></TD>
   <TD width="10%">&nbsp;</TD>
</TR>
<TR>
  <TD align="left">&nbsp;</TD>
  <TD width="80%">&nbsp;</TD>
  <TD width="10%">&nbsp;</TD>
</TR>
<TR>
   <TD align="left" width="10%"><FONT size="2" face="serif">23.3*</FONT></TD>
   <TD width="80%"><FONT size="2" face="serif">Consent of Deloitte &amp; Touche
    LLP.</FONT></TD>
   <TD width="10%">&nbsp;</TD>
</TR>
<TR>
  <TD align="left">&nbsp;</TD>
  <TD width="80%">&nbsp;</TD>
  <TD width="10%">&nbsp;</TD>
</TR>
<TR>
   <TD align="left" width="10%"><FONT size="2" face="serif">24.1*</FONT></TD>
   <TD width="80%"><FONT size="2" face="serif">Power of Attorney (included in
    the signature page of this Registration Statement)</FONT></TD>
   <TD width="10%">&nbsp;</TD>
</TR>
<TR>
   <TD width="10%" align="left">&nbsp;</TD>
   <TD width="80%">&nbsp;</TD>
   <TD width="10%">&nbsp;</TD>
</TR>
<TR>
   <TD align="left" width="10%"><FONT size="2" face="serif">99.1*</FONT></TD>
   <TD width="80%"><FONT size="2" face="serif">Inveresk Research Group, Inc.
       2002 Stock Option and Incentive Compensation Plan (Amended and Restated
    as of May 4, 2004).</FONT></TD>
   <TD width="10%">&nbsp;</TD>
</TR>
<TR>
  <TD align="left">&nbsp;</TD>
  <TD width="80%">&nbsp;</TD>
  <TD width="10%">&nbsp;</TD>
</TR>
<TR>
   <TD align="left" width="10%"><FONT size="2" face="serif">99.2*</FONT></TD>
   <TD width="80%"><FONT size="2" face="serif">Inveresk Research Group, Inc.
    2002 Non-Employee Directors Stock Option Plan.</FONT></TD>
   <TD width="10%">&nbsp;</TD>
</TR>
</TABLE>
<table width="100%" border="0" cellspacing="0" cellpadding="0">
  <tr align="left" valign="top">
    <td colspan="2"><hr align="left" width="10%" size=1 noshade color=GRAY></td>
  </tr>
  <tr align="left" valign="top">
    <td width="3%"><font size="2" face="serif">*</font><font size="2">&nbsp;</font></td>
    <td width="97%"><font size="2"><font face="serif">Filed
    herewith. </font></font> </td>
  </tr>
  <tr align="left" valign="top">
    <td width="3%"><font size="2" face="serif">**</font><font size="2">&nbsp;<font face="serif"></font></font></td>
    <td width="97%"> <font size="2"><font face="serif">Previously
          filed as an exhibit to Amendment No. 2 to the Registrant&#146;s Registration
          Statement on Form S-1 (File No. 333-35524), filed June 23, 2000 and
    incorporated by reference herein. </font></font> </td>
  </tr>
</table>
<P align="center">
  <FONT size="2" face="serif"><br>
  10</FONT>
</P>
<HR noshade align="center" width="100%" size=3>
</BODY>
</HTML>
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{"company-data": {"conformed-name": "CHARLES RIVER LABORATORIES INTERNATIONAL INC", "cik": "0001100682", "assigned-sic": "2836", "irs-number": "061397316"}, "filing-values": {"form-type": "S-8", "act": "33", "file-number": "333-119846", "film-number": "041087328"}, "business-address": {"street1": "261 BALLARDVALE STREET", "city": "WILMINGTON", "state": "MA", "zip": "01867", "phone": "9786586000"}, "mail-address": {"street1": "251 BALLARDVALE ST", "city": "WILMINGTON", "state": "MA", "zip": "01887"}, "former-company": {"former-conformed-name": "CHARLES RIVER LABORATORIES HOLDINGS INC", "date-changed": "19991208"}}
S-8
As filed with the Securities
          and Exchange Commission on
October 20,
          2004
Registration No. 333-_____
UNITED STATES
SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM S-8
REGISTRATION STATEMENT UNDER THE
SECURITIES ACT OF 1933
CHARLES RIVER LABORATORIES
INTERNATIONAL, INC.
(Exact Name of Registrant as Specified
in Its Charter)
Delaware
06-1397316
(State of
      Incorporation)
(I.R.S. Employer
Identification No.)
251 Ballardvale St., Wilmington,
      MA 01887
(Address of Principal Executive
      Offices, Including Zip Code)
Inveresk Research Group,
            Inc. 2002 Stock Option and Incentive
Compensation Plan
Inveresk Research Group, Inc. 2002 Non-Employee Directors Stock Option Plan
(Full Title of the Plans)
Dennis R. Shaughnessy
Senior Vice President
and General Counsel
Charles River Laboratories International,
    Inc.
251 Ballardvale St.
Wilmington, MA 01887
(Name and Address of Agent for Service)
(978)
            658-6000
Telephone Number, Including
    Area Code, of Agent For Service
CALCULATION OF REGISTRATION FEE
Title
         of Securities To Be Registered
Amount To
         Be
Registered(1)
Proposed Maximum
Offering Price Per
Share
Proposed Maximum
Aggregate Offering
Price
Amount of
Registration Fee
Common Stock, $0.01 par value per
    share
1,476,658
(4)
$19.07
(2)
$28,159,868.07
(2)
$3,567.86
Common Stock, $0.01 par value per share
1,539,324
(5)
$46.29
(3)
$71,255,307.96
(3)
$9,028.05
(1)
This Registration Statement shall
        also cover any additional shares of Registrant's common stock that
        may be offered to prevent dilution by reason of any stock dividend, stock
    split, recapitalization or other similar transactions.
(2)
Estimated solely for the purpose
        of computing the registration fee of options granted and outstanding
        pursuant to Rule 457(h) under the Securities Act of 1933, based on a
    weighted average exercise price of $19.07.
(3)
Estimated solely for the purpose of
        computing the registration fee pursuant to Rule 457(c) and (h) under
        the Securities Act of 1933, as amended, based on the average of the high
        ($46.67) and low ($45.90) prices of the Registrant's Common Stock,
        $0.01 par value per share, reported on the New York Stock Exchange on
    October 13, 2004.
(4)
Represents shares subject to issuance
        upon the exercise of outstanding stock options under the Inveresk Research
        Group, Inc. 2002 Stock Option and Incentive Compensation Plan (amended
        and restated as of May 4, 2004) and the Inveresk Research Group, Inc.
        2002 Non-Employee Directors Stock Option Plan (collectively, the "Inveresk
        Plans") and assumed by Registrant on October 20, 2004 in connection
        with the merger described in the Explanatory Note on the following page
    of this Registration Statement.
(5)
Represents shares registered for issuance,
        previously issuable under the Employee Plan, adjusted to reflect the
        terms of the merger described in the Explanatory Note on the following
    page of this Registration Statement.
EXPLANATORY NOTE
Pursuant to
  the Agreement and Plan of Merger dated as of June 30, 2004, by and among Charles
  River Laboratories International, Inc. (the "Registrant"), Inveresk
  Research Group, Inc. ("Inveresk"), Indigo
Merger I Corp. and Indigo Merger II LLC ("Merger Sub II") (as successor
to Indigo Merger II Corp.), as amended by Amendment No. 1, dated as of September
15, 2004 (as so amended, the "Merger Agreement"), on October 20, 2004
 Indigo Merger I Corp., a wholly owned subsidiary of the Registrant, merged with
and into Inveresk, with Inveresk continuing as the initial surviving corporation,
and immediately thereafter, the initial surviving corporation merged with and
into  Merger Sub II, a wholly owned subsidiary of the Registrant, with Merger
Sub II (renamed Inveresk Research Group, LLC) continuing as the surviving company.
The shares of Registant's
common stock registered are issuable pursuant to options granted under the Inveresk
Plans or reserved for future issuance.
Part II. Information Required in the Registration Statement
Item 3: Incorporation of Documents by Reference
We hereby incorporate by reference into this Registration
  Statement the following documents previously filed with the Securities and
  Exchange Commission (the "Commission") pursuant to the Securities Exchange Act of 1934,
as amended (the "Exchange Act"):
(a) The Registrant's
  annual report on Form 10-K for the fiscal year ended December 27, 2003;
(b) All reports
  filed by the Registrant pursuant to Section 13(a) or 15(d) of the Exchange
  Act since December 27, 2003, the end of the fiscal year convened by the Registrant's
  annual report referred to in (a); and
(c) The description
  of the Registrant's Common Stock, $0.01 par value per share, contained in the Registrant's
  Registration Statement on Form S-1 dated June 23, 2000, filed pursuant to Section
  12 of the Exchange Act (No. 333-35524), including any amendment or report filed
  for the purpose of updating such description.
All other documents
  filed by the Registrant with the Commission pursuant to Sections 13(a), 13(c),
  14 and 15(d) of the Exchange Act subsequent to the date of this Registration
  Statement and prior to the filing of a post-effective amendment to this Registration
  Statement which indicate that all securities offered have been sold or which
  de-register all securities then remaining unsold, shall be deemed to be incorporated
  by reference in this Registration Statement and to be a part hereof from the
  date of filing such documents (such documents, and the documents enumerated
  above, being hereinafter referred to collectively as the "Incorporated Documents").
2
Any statement contained in an Incorporated Document shall be deemed to be modified or superseded for purposes of this Registration Statement to the extent that a statement contained herein or in any
other subsequently filed Incorporated Document modifies or supersedes such statement. Any such statements so modified or superseded shall not be deemed, except as so modified or superseded, to constitute a part of this Registration Statement.
Item 4. Description of Securities
Not applicable.
Item 5. Interest of Named Experts and Counsel
Dennis R. Shaughnessy,
  who has issued the opinion of the Registrant's law department on the legality of the Common Stock of the Registrant offered hereby, is Senior Vice President, Corporate
Development, General Counsel and Secretary of the Registrant. Mr. Shaughnessy owns the Registrant's Common Stock and holds employee stock options to purchase the Registrant's
Common Stock.
Item 6. Indemnification of Directors and Officers
Section 102
  of the Delaware General Corporation Law (the "DGCL") allows a corporation to eliminate or limit the personal liability of directors of a corporation to the corporation or its
stockholders for monetary damages for a breach of fiduciary duty as a director, except where the director breached his duty of loyalty, failed to act in good faith, engaged in intentional misconduct or knowingly violated a law, authorized the
payment of a dividend or approved a stock repurchase in violation of Delaware corporate law or obtained an improper personal benefit. Article ELEVENTH of the Registrant's Amended and Restated Certificate of Incorporation includes such a
provision. Furthermore, Article ELEVENTH of the Registrant's Amended and
Restated Certificate of Incorporation provides that if the DGCL is amended to
further eliminate or limit the personal liability of directors, then the liability
of a director of the Registrant shall be eliminated or limited to the fullest
extent permitted by the DGCL, as so amended.
Section 145
  of the DGCL provides that a corporation has the power to indemnify a director,
  officer, employee or agent of the corporation and certain other persons serving
  at the request of the corporation in related capacities against amounts paid
  and expenses incurred in connection with an action, suit or proceeding (including
  attorneys' fees, judgments, fines and amounts paid in settlement in connection
  with specified actions, suits or proceedings) to which he is or is threatened
  to be made a party by reason of such position, if such person shall have acted
  in good faith and in a manner he reasonably believed to be in or not opposed
  to the best interests of the corporation, and, with respect to any criminal
  proceeding, if such person had no reasonable cause to believe his
3
conduct was unlawful; provided that, in the case of actions brought by or in the right of the corporation, no indemnification shall be made with respect to any matter as to which such person shall have been adjudged to be liable
to the corporation unless and only to the extent that the adjudicating court determines that such indemnification is proper under the circumstances.
Article SIXTH
  of the Registrant's Amended and Restated Certificate of Incorporation
  provides the Registrant (i) may indemnify any persons whom it shall have power
  to indemnify thereunder from and against any and all of the expenses, liabilities
  or other matters referred to in or covered thereby, (ii) shall indemnify each
  such person if he or she is or is threatened to be made a party to any threatened,
  pending or completed action, suit or proceeding by reason of the fact that
  he or she is or was a director, officer or employee of the Registrant or because
  he or she was serving the Registrant or any other legal entity in any capacity
  at the request of the Registrant while a director, officer or employee of the
  Registrant and (iii) shall pay the expense of such a current or former director,
  officer or employee incurred in connection with any such action, suit or proceeding
  in advance of the final disposition of such action, suit or proceeding. The
  indemnification and advancement of expenses provided for herein shall not be
  deemed exclusive of any other rights to which those entitled to indemnification
  or advancement of expenses may be entitled under any by-law, agreement, contract
  or vote of stockholders or disinterested directors or pursuant to the direction
  (however embodied) of any count of competent jurisdiction or otherwise, both
  as to action in his or her official capacity and as to action in another capacity
  while holding such office, and shall continue as to a person who has ceased
  to be a director, officer or employee and shall inure to the benefit of the
  heirs, executors and administrators of such a person.
Item 7. Exemption from Registration Claimed.
Not applicable.
Item 8. Exhibits.
The following exhibits are filed as part of this Registration Statement:
Exhibit No.
Description of Documents
4.1**
Form of certificate representing
       shares of common stock, $0.01 par value per share.
4.2**
Amended and Restated Certificate
       of Incorporation of Charles River Laboratories International, Inc.
4.3**
Amended and Restated By-laws of
       Charles River Laboratories International, Inc.
5.1*
Opinion of Dennis R. Shaughnessy, Esq.
23.1*
Consent of Dennis R. Shaughnessy, Esq. (included in Exhibit 5.1).
4
23.2*
Consent of PricewaterhouseCoopers LLP.
23.3*
Consent of Deloitte & Touche
    LLP.
24.1*
Power of Attorney (included in
    the signature page of this Registration Statement)
99.1*
Inveresk Research Group, Inc.
       2002 Stock Option and Incentive Compensation Plan (Amended and Restated
    as of May 4, 2004).
99.2*
Inveresk Research Group, Inc.
    2002 Non-Employee Directors Stock Option Plan.
*
Filed
    herewith.
**
Previously
          filed as an exhibit to Amendment No. 2 to the Registrant's Registration
          Statement on Form S-1 (File No. 333-35524), filed June 23, 2000 and
    incorporated by reference herein.
Item 9. Undertakings
A. The undersigned Registrant hereby undertakes:
(1) to file, during any period in which offers or sales are being made, a post-effective amendment to this Registration Statement:
(i) to include
    any prospectus required by Section 10(a)(3) of the Securities Act of 1933,
    as amended (the "Securities Act");
(ii) to reflect
    in the prospectus any facts or events arising after the effective date of the
    Registration Statement (or the most recent post-effective amendment thereof)
    which, individually or in the aggregate, represent a fundamental change in
    the information set forth in the Registration Statement. Notwithstanding the
    foregoing, any increase or decrease in volume of securities offered (if the
    total dollar value of securities offered would not exceed that which was registered)
    and any deviation from the low or high end of the estimated maximum offering
    range may be reflected in the form of prospectus filed with the Commission
    pursuant to Rule 424(b) if, in the aggregate, the changes in volume and price
    represent no more than a 20% change in the maximum aggregate offering price
    set forth in the "Calculation of Registration Fee" table in the effective
    Registration Statement; and
(iii) to
    include any material information with respect to the plan of distribution
    not previously disclosed in the Registration Statement or any material change
    to such information in the Registration  Statement; provided, however, that
    clauses (1)(i) and (1)(ii) shall not apply if the information required to
    be included in a post-effective amendment by those clauses is contained in
    periodic reports filed by the Registrant pursuant to Section 13(a)
5
or Section 15(d) of the Exchange Act that are incorporated by reference into the Registration Statement;
(2) that, for the purpose of determining any liability under the Securities Act, each such post-effective amendment shall be deemed to be a new registration statement relating to the securities
offered therein and the offering of such securities at that time shall be deemed to be the initial
bona fide
offering thereof; and
(3) to remove from registration by means of a post-effective amendment any of the securities being registered which remain unsold at the termination of the offering.
B. The undersigned
  Registrant hereby undertakes that, for purposes of determining any liability
  under the Securities Act, each filing of the Registrant's annual report
  pursuant to Section 13(a) or Section 15(d) of the Exchange Act that is incorporated
  by reference in this Registration Statement shall be deemed to be a new registration
  statement relating to the securities offered therein, and the offering of such
  securities at that time shall be deemed to be the initial
bona fide
offering thereof.
C. Insofar as indemnification for liabilities arising under the Securities Act may be permitted to directors, officers and controlling persons of the Registrant pursuant to the indemnification
provisions summarized in Item 6 or otherwise, the Registrant has been advised that in the opinion of the Commission, such indemnification is against public policy as expressed in the Securities Act and is, therefore, unenforceable. In the event that
a claim for indemnification against such liabilities (other than the payment by the Registrant of expenses incurred or paid by a director, officer, or controlling person of the Registrant in the successful defense of any action, suit or proceeding)
is asserted by such director, officer or controlling person in connection with the securities being registered, the Registrant will, unless in the opinion of its counsel the matter has been settled by controlling precedent, submit to a court of
appropriate jurisdiction the question whether such indemnification by it is against public policy as expressed in the Securities Act and will be governed by the final adjudication of such issue.
6
SIGNATURES
Pursuant to the requirements of the Securities Act, the Registrant certifies that it has reasonable grounds to believe that it meets all of the requirements for filing on Form S-8 and has duly caused
this Registration Statement to be signed on its behalf by the undersigned, thereunto duly authorized, in the Town of Wilmington, Commonwealth of Massachusetts, as of the 20th day of
October 2004.
CHARLES RIVER LABORATORIES
INTERNATIONAL,INC.
By:
/s/ James C. Foster
James C. Foster
Chairman, Chief Executive Officer
and President
7
POWER OF ATTORNEY AND SIGNATURES
We, the undersigned officers and directors of Charles River Laboratories International, Inc., hereby severally constitute and appoint James C. Foster, Dennis R. Shaughnessy and Thomas F. Ackerman
and each of them singly, as true and lawful attorneys-in-fact, with full power of substitution, to sign for us in our names in the capacities indicated below, all additional amendments (including post-effective amendments), together with any
exhibits thereto or documents therewith, to this Registration Statement, and generally to do all things in our names and on our behalf in such capacities to enable Charles River Laboratories International, Inc. to comply with the provisions of the
Securities Act, and all applicable requirements of the Commission.
Pursuant to the requirements of the Securities Act, this Registration Statement on Form S-8 has been signed by the following persons in the capacities indicated on October 20, 2004.
Signature
Title
/s/ James C. Foster
Chairman, President, Chief Executive Officer and
James C. Foster
Director (Principal Executive Officer)
/s/ Thomas A. Ackerman
Senior Vice President of Finance and Chief Financial
Thomas A. Ackerman
Officer (Principal Financial and Accounting Officer)
/s/ Robert Cawthorn
Director
Robert Cawthorn
/s/ Stephen D. Chubb
Director
Stephen D. Chubb
/s/ George E. Massaro
Director
George E. Massaro
/s/ Linda McGoldrick
Director
Linda McGoldrick
8
/s/ George M. Milne
Director
George M. Milne
/s/ Douglas E. Rogers
Director
Douglas E. Rogers
/s/ Samuel O. Thier
Director
Samuel O. Thier
/s/ William H. Waltrip
Director
William H. Waltrip
9
Exhibit Index
Exhibit No.
Description of Documents
4.1**
Form of certificate representing
       shares of common stock, $0.01 par value per share.
4.2**
Amended and Restated Certificate
       of Incorporation of Charles River Laboratories International, Inc.
4.3**
Amended and Restated By-laws of
       Charles River Laboratories International, Inc.
5.1*
Opinion of Dennis R. Shaughnessy, Esq.
23.1*
Consent of Dennis R. Shaughnessy, Esq. (included in Exhibit 5.1).
23.2*
Consent of PricewaterhouseCoopers LLP.
23.3*
Consent of Deloitte & Touche
    LLP.
24.1*
Power of Attorney (included in
    the signature page of this Registration Statement)
99.1*
Inveresk Research Group, Inc.
       2002 Stock Option and Incentive Compensation Plan (Amended and Restated
    as of May 4, 2004).
99.2*
Inveresk Research Group, Inc.
    2002 Non-Employee Directors Stock Option Plan.
*
Filed
    herewith.
**
Previously
          filed as an exhibit to Amendment No. 2 to the Registrant's Registration
          Statement on Form S-1 (File No. 333-35524), filed June 23, 2000 and
    incorporated by reference herein.
10