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<p style="margin: 0pt; text-align: center; color: rgb(0, 0, 0); text-indent: 0pt; font-family: Times New Roman; font-size: 10pt; background-color: rgb(255, 255, 255);"><font style="font-family: Times New Roman, Times, serif; font-size: 10pt;"><b>As filed with the Securities and Exchange Commission on March 7</b><b>, 2023</b></font></p>

<p style="margin: 0pt; text-align: right; font-family: Times New Roman, Times, serif; font-size: 10pt;"><b>Registration No. 333- </b></p>

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<p style="margin: 0pt 54pt 0pt 51.1pt; text-align: center; font-family: &quot;Times New Roman&quot;, Times, Serif; font-size: 18pt;"><b>UNITED STATES</b></p>

<p style="margin: 0pt 54pt 0pt 51.15pt; text-align: center; font-family: &quot;Times New Roman&quot;, Times, Serif; font-size: 18pt;"><b>SECURITIES AND EXCHANGE COMMISSION</b></p>

<p style="margin: 0pt 54pt 0pt 51.15pt; text-align: center; font-family: &quot;Times New Roman&quot;, Times, Serif; font-size: 10pt;"><b>WASHINGTON, D.C. 20549</b></p>

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<p style="margin: 0pt 54pt 0pt 51.1pt; text-align: center; font-family: &quot;Times New Roman&quot;, Times, Serif; font-size: 18pt;"><b>FORM S-8</b></p>

<p style="margin: 0pt; text-align: center; font-family: &quot;Times New Roman&quot;, Times, Serif; font-size: 18pt;"><b>REGISTRATION STATEMENT </b></p>

<p style="margin: 0pt; text-align: center; font-family: &quot;Times New Roman&quot;, Times, Serif; font-size: 10pt;"><i>UNDER&nbsp; </i></p>

<p style="margin: 0pt; text-align: center; font-family: &quot;Times New Roman&quot;, Times, Serif; font-size: 10pt;"><i>THE SECURITIES ACT OF 1933</i></p>

<p style="margin: 0pt; text-align: center; font-family: Times New Roman, Times, serif; font-size: 10pt;">&nbsp;</p>

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<p style="margin: 0pt; text-align: center; font-family: Times New Roman, Times, serif; font-size: 10pt;">&nbsp;</p>

<p style="margin: 0pt; text-align: center; color: rgb(0, 0, 0); text-indent: 0pt; font-family: Times New Roman; font-size: 24pt; background-color: rgb(255, 255, 255);"><b>Zevra Therapeutics, Inc.</b></p>

<p style="margin: 0pt 54pt 0pt 51.15pt; text-align: center; font-family: &quot;Times New Roman&quot;, Times, Serif; font-size: 10pt;"><b>(Exact Name of Registrant as Specified in Its Charter)</b></p>

<p style="font-family: &quot;Times New Roman&quot;, Times, serif; font-size: 10pt; margin: 0pt;">&nbsp;</p>

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			<p style="margin: 0pt; text-align: center; font-family: &quot;Times New Roman&quot;, Times, Serif; font-size: 10pt;"><b>Delaware</b></p>
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			<td style="width: 18%; font-family: &quot;Times New Roman&quot;, Times, Serif; font-size: 10pt; vertical-align: top;">&nbsp;</td>
			<td style="width: 37.7%; font-family: &quot;Times New Roman&quot;, Times, Serif; font-size: 10pt; vertical-align: top;">
			<p style="margin: 0pt 1.8pt 0pt 0pt; text-align: center; font-family: &quot;Times New Roman&quot;, Times, Serif; font-size: 10pt;"><b>20</b><b>-</b><b>5894398</b></p>
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			<p style="margin: 0pt; text-align: center; font-family: &quot;Times New Roman&quot;, Times, Serif; font-size: 10pt;"><b>(<font style="font-size:8pt;">State or Other Jurisdiction of </font></b></p>

			<p style="margin: 0pt; text-align: center; font-family: &quot;Times New Roman&quot;, Times, Serif; font-size: 10pt;"><b><font style="font-size:8pt;">Incorporation or Organization)</font></b></p>
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			<td style="width: 18%; font-family: &quot;Times New Roman&quot;, Times, Serif; font-size: 10pt; vertical-align: top;">&nbsp;</td>
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			<p style="margin: 0pt 1.8pt 0pt 0pt; text-align: center; font-family: &quot;Times New Roman&quot;, Times, serif; font-size: 8pt;"><b>(I.R.S. Employer</b></p>

			<p style="margin: 0pt 1.8pt 0pt 0pt; text-align: center; font-family: &quot;Times New Roman&quot;, Times, serif; font-size: 8pt;"><b>Identification No.)</b></p>
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<p style="margin: 0pt 54pt 0pt 0pt; text-align: justify; font-family: Times New Roman, Times, serif; font-size: 10pt;">&nbsp;</p>

<p style="margin: 0pt; text-align: center; font-family: &quot;Times New Roman&quot;, Times, Serif; font-size: 10pt;"><b>1180&nbsp;Celebration Boulevard, Suite </b><b>103</b></p>

<p style="margin: 0pt; text-align: center; font-family: &quot;Times New Roman&quot;, Times, Serif; font-size: 10pt;"><b>Celebration,&nbsp;FL 34747</b></p>

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<p style="margin: 0pt; text-align: center; font-family: &quot;Times New Roman&quot;, Times, serif; font-size: 8pt;"><b>(Address of Principal Executive Offices) (Zip Code)</b></p>

<p style="margin: 0pt; text-align: center; font-family: &quot;Times New Roman&quot;, Times, Serif; font-size: 10pt;">&nbsp;</p>

<p style="margin: 0pt; text-align: center; font-family: &quot;Times New Roman&quot;, Times, Serif; font-size: 10pt;"><b>&nbsp;Zevra Therapeutics, Inc.</b></p>

<p style="margin: 0pt; text-align: center; font-family: &quot;Times New Roman&quot;, Times, Serif; font-size: 10pt;"><b>Amended and Restated 2014 Equity Incentive Plan</b></p>

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<p style="margin: 0pt; text-align: center; font-family: &quot;Times New Roman&quot;, Times, serif; font-size: 8pt;"><b>(Full Title of the Plan)</b></p>

<p style="font-family: &quot;Times New Roman&quot;, Times, serif; font-size: 10pt; margin: 0pt;">&nbsp;</p>

<p style="margin: 0pt; text-align: center; font-family: &quot;Times New Roman&quot;, Times, Serif; font-size: 10pt;">&nbsp;</p>

<p style="margin: 0pt; text-align: center; font-family: &quot;Times New Roman&quot;, Times, Serif; font-size: 10pt;"><b>R. LaDuane Clifton, CPA</b></p>

<p style="margin: 0pt; text-align: center; font-family: &quot;Times New Roman&quot;, Times, Serif; font-size: 10pt;"><b>Chief Financial Officer, Secretary and Treasurer</b></p>

<p style="margin: 0pt; text-align: center; font-family: &quot;Times New Roman&quot;, Times, Serif; font-size: 10pt;"><b>Zevra Therapeutics, Inc.</b></p>

<p style="margin: 0pt; text-align: center; font-family: &quot;Times New Roman&quot;, Times, Serif; font-size: 10pt;"><b>1180&nbsp;Celebration Boulevard, Suite 103</b></p>

<p style="margin: 0pt; text-align: center; font-family: &quot;Times New Roman&quot;, Times, Serif; font-size: 10pt;"><b>Celebration,&nbsp;FL 34747</b></p>

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<p style="margin: 0pt; text-align: center; font-family: &quot;Times New Roman&quot;, Times, serif; font-size: 8pt;"><b>(Name and Address of Agent for Service)</b></p>

<p style="margin: 0pt; text-align: center; font-family: &quot;Times New Roman&quot;, Times, serif; font-size: 8pt;">&nbsp;</p>

<p style="margin: 0pt; text-align: center; font-family: &quot;Times New Roman&quot;, Times, serif; font-size: 10pt;"><b>(</b><b>321</b><b>) 939-3416</b></p>

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<p style="margin: 0pt; text-align: center; font-family: &quot;Times New Roman&quot;, Times, serif; font-size: 8pt;"><b>(Telephone Number, Including Area Code, of Agent for Service)</b></p>

<p style="margin: 0pt; text-align: center; font-family: &quot;Times New Roman&quot;, Times, serif; font-size: 8pt;">&nbsp;</p>

<p style="font-family: &quot;Times New Roman&quot;, Times, serif; font-size: 10pt; margin: 0pt;">&nbsp;</p>

<p style="margin: 0pt; text-align: center; font-family: &quot;Times New Roman&quot;, Times, Serif; font-size: 10pt;"><b><i>Copies to:</i></b></p>

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			<p style="margin: 0pt; text-align: center; font-family: &quot;Times New Roman&quot;, Times, Serif; font-size: 10pt;"><b>Nathan Ajiashvili, Esq.</b></p>

			<p style="margin: 0pt; text-align: center; font-family: &quot;Times New Roman&quot;, Times, Serif; font-size: 10pt;"><b><font style="background-color:#ffffff;">Latham &amp; Watkins LLP</font></b></p>

			<p style="margin: 0pt; text-align: center; font-family: &quot;Times New Roman&quot;, Times, Serif; font-size: 10pt;"><b><font style="background-color:#ffffff;">1271 Avenue of the Americas</font></b></p>

			<p style="margin: 0pt; text-align: center; font-family: &quot;Times New Roman&quot;, Times, Serif; font-size: 10pt;"><b><font style="background-color:#ffffff;">New York, NY&nbsp;10020</font></b></p>

			<p style="margin: 0pt; text-align: center; font-family: &quot;Times New Roman&quot;, Times, Serif; font-size: 10pt;"><b><font style="background-color:#ffffff;">(212) 906-1200</font></b></p>
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<p style="margin: 0pt; text-align: center; font-family: &quot;Times New Roman&quot;, Times, Serif; font-size: 10pt;"><i>&nbsp;</i></p>

<p style="margin: 0pt; text-align: justify; font-family: &quot;Times New Roman&quot;, Times, Serif; font-size: 10pt;">Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, a smaller reporting company or an emerging growth company. See the definitions of &#8220;large accelerated filer,&#8221; &#8220;accelerated filer&#8221;,&nbsp;&#8220;smaller reporting company&#8221; and "emerging growth company" in Rule 12b-2 of the Exchange Act.</p>

<p style="margin: 0pt; text-align: justify; font-family: &quot;Times New Roman&quot;, Times, Serif; font-size: 10pt;">&nbsp;</p>

<p style="margin: 0pt; text-align: justify; font-family: &quot;Times New Roman&quot;, Times, Serif; font-size: 10pt;">Large accelerated filer &#9744;&nbsp;&nbsp;&nbsp;&nbsp; Accelerated filer &#9744;&nbsp;&nbsp;&nbsp;&nbsp; Non-accelerated filer &#9746;&nbsp; &nbsp; &nbsp;Smaller reporting company&nbsp;&#9746;&nbsp; &nbsp; &nbsp;Emerging growth company &#9744;&nbsp; &nbsp;&nbsp;</p>

<p style="margin: 0pt; text-align: justify; font-family: &quot;Times New Roman&quot;, Times, Serif; font-size: 10pt;">&nbsp;</p>

<p style="font-family: &quot;Times New Roman&quot;, Times, serif; font-size: 10pt; margin: 0pt;">&nbsp;</p>

<p style="margin: 0pt; text-align: justify; font-family: &quot;Times New Roman&quot;, Times, serif; font-size: 10pt;">If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to<font style="font-family: &quot;Times New Roman&quot;, Times, serif; font-size: 10pt;">&nbsp;Section 7(a)(2)(B)&nbsp;of the Securities Act.&nbsp;&nbsp;&#9744;</font></p>

<p style="margin: 0pt; text-align: justify; font-family: Times New Roman; font-size: 10pt;">&nbsp;</p>

<p style="margin: 0pt 36pt; text-align: center; text-transform: uppercase; text-indent: -36pt; font-family: Times New Roman, Times, serif; font-size: 10pt;">&nbsp;</p>

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<div class="PGNUM" style="width: 100%; text-align: center; font-family: &quot;Times New Roman&quot;, Times, Serif; font-size: 10pt;">2</div>

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<div class="PGHDR" style="width: 100%; text-align: left;">&nbsp;</div>
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<p style="margin: 0pt 36pt; text-align: center; text-transform: uppercase; text-indent: -36pt; font-family: Times New Roman, Times, serif; font-size: 10pt;">&nbsp;</p>

<p style="margin: 0pt; text-align: center; text-transform: uppercase; font-family: Times New Roman, Times, serif; font-size: 10pt;"><b>Explanatory Note</b></p>

<p style="font-family: &quot;Times New Roman&quot;, Times, serif; font-size: 10pt; margin: 0pt;">&nbsp;</p>

<p style="margin: 0pt; text-align: justify; font-family: Times New Roman, Times, serif; font-size: 10pt;">This Registration Statement on Form S-8 is being filed for the purpose of registering an <font style="font-family: Times New Roman, Times, serif; font-size: 10pt;">additional&nbsp;<font style="background-color:#ffffff;">2,781,837&nbsp;shares of the Registrant&#8217;s Common Stock to be issued pursuant to the Registrant&#8217;s Amended and Restated 2014 Equity Incentive&nbsp;Plan (the <i>"<b>A&amp;R 2014 Plan</b>"</i>). A Registration Statement of the Registrant on Form S-8 relating to the A&amp;R 2014 Plan is effective.</font></font></p>

<p style="margin: 0pt; text-align: justify; font-family: Times New Roman, Times, serif; font-size: 10pt;">&nbsp;</p>

<p style="margin: 0pt; text-align: center; font-family: Times New Roman, Times, serif; font-size: 10pt;"><b>INCORPORATION BY REFERENCE OF CONTENTS OF REGISTRATION </b></p>

<p style="margin: 0pt; text-align: center; font-family: Times New Roman, Times, serif; font-size: 10pt;"><b>STATEMENTS ON FORM S-8 </b></p>

<p style="font-family: &quot;Times New Roman&quot;, Times, serif; font-size: 10pt; margin: 0pt;">&nbsp;</p>

<p style="margin: 0pt; text-align: justify; font-family: Times New Roman, Times, serif; font-size: 10pt;"><font style="font-family: Times New Roman, Times, serif; font-size: 10pt;">The contents of the Registration Statements on Form S-8 (File Nos. <a href="http://www.sec.gov/Archives/edgar/data/1434647/000119312515154390/d913215ds8.htm" style="-sec-extract:exhibit;">333-203703</a>, <a href="http://www.sec.gov/Archives/edgar/data/1434647/000119312516515166/d166295ds8.htm" style="-sec-extract:exhibit;">333-210369</a>, <a href="http://www.sec.gov/Archives/edgar/data/1434647/000143774917005022/kmph20170320_s8.htm" style="-sec-extract:exhibit;">333-216858</a>, <a href="http://www.sec.gov/Archives/edgar/data/1434647/000143774918005933/kmph20180110_s8.htm" style="-sec-extract:exhibit;">333-224062</a>, <a href="http://www.sec.gov/Archives/edgar/data/1434647/000143774919003803/kmph20190220_s8.htm" style="-sec-extract:exhibit;">333-230041</a>,<a href="http://www.sec.gov/Archives/edgar/data/1434647/000143774920003968/kmph20200227_s8.htm" style="-sec-extract:exhibit;"> 333-236794</a>, <a href="http://www.sec.gov/Archives/edgar/data/1434647/000143774921002025/kmph20210202_s8.htm" style="-sec-extract:exhibit;">333-252743</a>, <a href="http://www.sec.gov/Archives/edgar/data/1434647/000119312521200486/d13864ds8.htm" style="-sec-extract:exhibit;">333-257429</a>), including any amendments thereto, as filed with the Securities and Exchange Commission (the &#8220;<b><i>Commission</i></b>&#8221;),&nbsp;are incorporated herein by reference and made a part of this Registration Statement.</font></p>

<p style="font-family: &quot;Times New Roman&quot;, Times, serif; font-size: 10pt; margin: 0pt;">&nbsp;</p>

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<div class="PGNUM" style="width: 100%; text-align: center; font-family: &quot;Times New Roman&quot;, Times, Serif; font-size: 10pt;">3</div>

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<div class="PGHDR" style="width: 100%; text-align: left;">&nbsp;</div>
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<p style="margin: 0pt; text-align: left; font-family: Times New Roman, Times, serif; font-size: 10pt;">&nbsp;</p>

<p style="margin: 0pt; text-align: left; font-family: Times New Roman, Times, serif; font-size: 10pt;"><b>ITEM</b><font style="font-family: Times New Roman, Times, serif; font-size: 10pt;"><b>&nbsp;8.&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;EXHIBITS</b></font></p>

<p style="font-family: &quot;Times New Roman&quot;, Times, serif; font-size: 10pt; margin: 0pt;">&nbsp;</p>

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			<td style="width: 10.6%; vertical-align: bottom; border-bottom-color: rgb(0, 0, 0); border-bottom-width: 1px; border-bottom-style: solid;">
			<p style="margin: 0pt; text-align: center; font-family: Times New Roman, Times, serif; font-size: 10pt;"><b>Exhibit </b></p>

			<p style="margin: 0pt; text-align: center; font-family: Times New Roman, Times, serif; font-size: 10pt;"><b>Number</b></p>
			</td>
			<td style="width: 90.5%; vertical-align: bottom; border-bottom-color: rgb(0, 0, 0); border-bottom-width: 1px; border-bottom-style: solid;">
			<p style="margin: 0pt; text-align: center; font-family: Times New Roman, Times, serif; font-size: 10pt;"><b>Description of the Exhibit</b></p>
			</td>
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			<p style="margin: 0pt; text-align: center; font-family: Times New Roman, Times, serif; font-size: 10pt;">4<font style="font-family: Times New Roman, Times, serif; font-size: 10pt;">.1</font></p>
			</td>
			<td style="width: 90.5%; vertical-align: top;">
			<p style="margin: 0pt; text-align: justify; font-family: Times New Roman, Times, serif; font-size: 10pt;"><a href="http://www.sec.gov/Archives/edgar/data/1434647/000119312515140072/d911803dex31.htm" style="-sec-extract:exhibit;">Amended and Restated Certificate of Incorporation&nbsp;of the Registrant (incorporated by reference to Exhibit 3.1 to the Registrant&#8217;s Current Report on Form 8-K (File No. 001-36913) filed on April 21, 2015)</a></p>
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			<td style="width: 10.6%; text-align: center; vertical-align: top;">4.2</td>
			<td style="width: 90.5%; vertical-align: top;"><a href="http://www.sec.gov/Archives/edgar/data/1434647/000119312518294252/d636304dex31.htm" style="-sec-extract:exhibit;">Certificate of</a><a href="http://www.sec.gov/Archives/edgar/data/1434647/000143774920025891/ex_218888.htm" style="-sec-extract:exhibit;">&nbsp;Amendment of Amended and Restated Certificate of Incorporation of the Registrant, effective as of December 23, 2020 (incorporated by reference to Exhibit 3.1 to the Registrant's Current Report on Form 8-K (File No. 001-36913) filed on December 23, 2020)</a></td>
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			<td style="width: 10.6%; text-align: center; vertical-align: top;">4.3</td>
			<td style="width: 90.5%; vertical-align: top;"><a href="http://www.sec.gov/Archives/edgar/data/1434647/000143774923004450/ex_478052.htm" style="-sec-extract:exhibit;"><u>Certificate of Amendment of Certificate of Incorporation of the Registrant, effective as of February 21, 2023 (incorporated by reference to Exhibit 3.1 to the Registrant's Current Report on Form 8-K (File No. 001-36913) filed on February 24, 2023)</u></a></td>
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			<td style="width: 10.6%; text-align: center; vertical-align: top;">4.4</td>
			<td><a href="http://www.sec.gov/Archives/edgar/data/1434647/000143774923004450/ex_479870.htm" style="-sec-extract:exhibit;"><u>Amended and Restated Bylaws of the Registrant (incorporated by reference to Exhibit 3.2 to the Registrant&#8217;s Current Report on Form 8-K (File No. 001-36913) filed on February 24, 2023)</u></a>
			<div style="display: none;">&nbsp;</div>
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			<p style="margin: 0pt; text-align: center; font-family: Times New Roman, Times, serif; font-size: 10pt;">5.1*</p>
			</td>
			<td style="width: 90.5%; vertical-align: top;">
			<p style="margin: 0pt; text-align: justify; font-family: Times New Roman, Times, serif; font-size: 10pt;"><a id="Exhibit 5.1" name="Exhibit 5.1"></a><a href="ex_477544.htm" style="-sec-extract:exhibit;">Opinion&nbsp;of Latham and Watkins LLP</a></p>
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			<p style="margin: 0pt; text-align: center; font-family: Times New Roman, Times, serif; font-size: 10pt;">23.1*</p>
			</td>
			<td style="width: 90.5%; vertical-align: top;">
			<p style="margin: 0pt; text-align: justify; font-family: Times New Roman, Times, serif; font-size: 10pt;"><a href="ex_477545.htm" style="-sec-extract:exhibit;">Consent of Ernst &amp; Young <font style="font-family: Times New Roman, Times, serif; font-size: 10pt;">LLP, Independent Registered Public Accounting Firm.</font></a></p>
			</td>
		</tr>
		<tr>
			<td style="width: 10.6%; vertical-align: top; text-align: center;">23.2*</td>
			<td style="width: 90.5%; vertical-align: top;"><a href="ex_484660.htm" style="-sec-extract:exhibit;">Consent of RSM US LLP, Independent Registered Public Accounting Firm.</a></td>
		</tr>
		<tr>
			<td style="width: 10.6%; vertical-align: top;">
			<p style="margin: 0pt; text-align: center; font-family: Times New Roman, Times, serif; font-size: 10pt;">23.3*</p>
			</td>
			<td style="width: 90.5%; vertical-align: top;">
			<p style="margin: 0pt; text-align: justify; font-family: Times New Roman, Times, serif; font-size: 10pt;"><a href="ex_477544.htm" style="-sec-extract:exhibit;">Consent of Latham &amp; Watkins LLP&nbsp;(included in Exhibit 5.1).</a></p>
			</td>
		</tr>
		<tr>
			<td style="width: 10.6%; vertical-align: top;">
			<p style="margin: 0pt; text-align: center; font-family: Times New Roman, Times, serif; font-size: 10pt;">24.1</p>
			</td>
			<td style="width: 90.5%; vertical-align: top;">
			<p style="margin: 0pt; text-align: justify; font-family: Times New Roman, Times, serif; font-size: 10pt;"><a href="#Power" style="-sec-extract:exhibit;">Power of Attorney (included on the signature page).</a></p>
			</td>
		</tr>
		<tr>
			<td style="width: 10.6%; vertical-align: top; text-align: center;">99.1</td>
			<td style="width: 90.5%; vertical-align: top;"><a href=" http://www.sec.gov/Archives/edgar/data/1434647/000143774921019912/ex_272734.htm" style="-sec-extract:exhibit;"><u>Amended and Restated 2014 Equity Incentive Plan (incorporated by reference to Exhibit 10.4 to the Registrant</u><u>&#8217;</u><u>s Quarterly Report on Form 10-Q (File No. 36913) filed on August 13, 2021)</u></a></td>
		</tr>
		<tr>
			<td style="width: 10.6%; vertical-align: top; text-align: center;">99.2</td>
			<td style="width: 90.5%; vertical-align: top;"><a href="http://www.sec.gov/Archives/edgar/data/1434647/000119312515087360/d793437dex1015.htm" style="-sec-extract:exhibit;">Form of Stock Option Grant Notice and Stock Option Agreement under 2014 Equity Incentive Plan (incorporated herein by reference to Exhibit 10.15 to the Registrant's Registration Statement on Form S-1 (File No. 333-202660) filed on March 11, 2015)</a></td>
		</tr>
		<tr>
			<td style="width: 10.6%; vertical-align: top; text-align: center;">99.3</td>
			<td style="width: 90.5%; vertical-align: top;"><a href="http://www.sec.gov/Archives/edgar/data/1434647/000119312515087360/d793437dex1016.htm" style="-sec-extract:exhibit;"><u>Form of Restricted Stock Unit Grant Notice and Restricted Stock Unit Award Agreement under 2014 Equity Incentive Plan (incorporated herein by reference to Exhibit 10.16 to the Registrant's Registration Statement on Form S-1 (File No. 333-202660) filed on March 11, 2015)</u></a></td>
		</tr>
		<tr>
			<td style="width: 10.6%; vertical-align: top; text-align: center;">107.1*</td>
			<td style="width: 90.5%; vertical-align: top;"><a href="ex_485268.htm" style="-sec-extract:exhibit;">Filing Fee Table</a></td>
		</tr>

</table>

<p style="margin: 0pt; text-align: left; font-family: Times New Roman, Times, serif; font-size: 10pt;">&nbsp;</p>

<p style="margin: 0pt; text-align: left; font-family: Times New Roman, Times, serif; font-size: 10pt;">* Filed herewith</p>

<p style="margin: 0pt; text-align: center; font-family: Times New Roman, Times, serif; font-size: 10pt;">&nbsp;</p>

<div class="PGBK" style="width: 100%; margin-right: 0pt; margin-left: 0pt;">
<div class="PGNUM" style="width: 100%; text-align: center; font-family: &quot;Times New Roman&quot;, Times, Serif; font-size: 10pt;">4</div>

<hr style="border: currentColor; border-image: none; width: 100%; height: 2px; color: rgb(0, 0, 0); page-break-after: always; background-color: rgb(0, 0, 0);">
<div class="PGHDR" style="width: 100%; text-align: left;">&nbsp;</div>
</div>

<p style="margin: 0pt; text-align: center; font-family: Times New Roman, Times, serif; font-size: 10pt;">&nbsp;</p>

<p style="margin: 0pt; text-align: center; font-family: Times New Roman, Times, serif; font-size: 10pt;"><b>SIGNATURES</b></p>

<p style="font-family: &quot;Times New Roman&quot;; font-size: 10pt; margin: 0pt;">&nbsp;</p>

<p style="margin: 0pt; text-align: justify; font-family: Times New Roman; font-size: 10pt;">Pursuant to the requirements of the Securities Act of 1933, as amended, the Registrant certifies that it has reasonable grounds to believe that it meets all of the requirements for filing on Form<font style="font-family: Times New Roman, Times, serif; font-size: 10pt;">&nbsp;S-8 and has duly caused this Registration Statement to be signed on its behalf by the undersigned, thereunto duly authorized, in the City of Celebration, State of Florida, on this 7th day of March, 2023.</font></p>

<p style="font-family: &quot;Times New Roman&quot;; font-size: 10pt; margin: 0pt;">&nbsp;</p>

<table border="0" cellpadding="0" cellspacing="0" style="margin: 0pt 0pt 0pt auto; width: 50%; font-family: Times New Roman; font-size: 10pt;">

		<tr>
			<td colspan="2" style="width: 5%;"><b>Zevra Therapeutics, Inc.</b></td>
			<td style="width: 20%;">&nbsp;</td>
		</tr>
		<tr>
			<td style="width: 5%;">&nbsp;</td>
			<td style="width: 75%;">&nbsp;</td>
			<td style="width: 20%;">&nbsp;</td>
		</tr>
		<tr>
			<td style="width: 5%;">By:</td>
			<td style="width: 75%; border-bottom-color: rgb(0, 0, 0); border-bottom-width: thin; border-bottom-style: solid;">/s/ R. LaDuane Clifton</td>
			<td style="width: 20%;">&nbsp;</td>
		</tr>
		<tr>
			<td style="width: 5%;">&nbsp;</td>
			<td style="width: 75%;">R. LaDuane Clifton, CPA</td>
			<td style="width: 20%;">&nbsp;</td>
		</tr>
		<tr>
			<td style="width: 5%;">&nbsp;</td>
			<td style="width: 75%;">Chief Financial Officer, Secretary and Treasurer</td>
			<td style="width: 20%;">&nbsp;</td>
		</tr>

</table>

<p style="margin: 0pt; text-align: center; font-family: Times New Roman, Times, serif; font-size: 10pt;">&nbsp;</p>

<div class="PGBK" style="width: 100%; margin-right: 0pt; margin-left: 0pt;">
<div class="PGNUM" style="width: 100%; text-align: center; font-family: &quot;Times New Roman&quot;, Times, Serif; font-size: 10pt;">5</div>

<hr style="border: currentColor; border-image: none; width: 100%; height: 2px; color: rgb(0, 0, 0); page-break-after: always; background-color: rgb(0, 0, 0);">
<div class="PGHDR" style="width: 100%; text-align: left;">&nbsp;</div>
</div>

<p style="margin: 0pt; text-align: center; font-family: Times New Roman, Times, serif; font-size: 10pt;">&nbsp;</p>

<p style="margin: 0pt; text-align: center; font-family: Times New Roman, Times, serif; font-size: 10pt;"><b><a id="Power of Attorney Title" name="Power of Attorney Title"></a>POWER OF ATTORNEY</b></p>

<p style="font-family: &quot;Times New Roman&quot;; font-size: 10pt; margin: 0pt;">&nbsp;</p>

<p style="margin: 0pt; text-align: justify; font-family: Times New Roman; font-size: 10pt;">KNOW ALL BY THESE PRESENTS, that each person whose signature appears below hereby constitutes and appoints Richard W. Pascoe<font style="font-family: Times New Roman, Times, serif; font-size: 10pt;">. and R. LaDuane Clifton, CPA&nbsp;and each or any one of them, his lawful attorney-in-fact and agent, with full power of substitution and resubstitution, for him and in his name, place and stead, in any and all capacities, to sign any and all amendments (including post-effective amendments) to this Registration Statement, and to file the same, with all exhibits thereto, and other documents in connection therewith, with the Securities and Exchange Commission, granting unto said attorneys-in-fact and agents, and each of them, full power and authority to do and perform each and every act and thing requisite and necessary to be done in connection therewith, as fully to all intents and purposes as he might or could do in person, hereby ratifying and confirming all that said attorneys-in-fact and agents, or any of them, or their or his substitutes or substitute, may lawfully do or cause to be done by virtue hereof.</font></p>

<p style="font-family: &quot;Times New Roman&quot;; font-size: 10pt; margin: 0pt;">&nbsp;</p>

<p style="margin: 0pt; text-align: justify; font-family: Times New Roman; font-size: 10pt;">Pursuant to the requirements of the Securities Act of 1933, as amended, this Registration Statement has been signed by the following persons in the capacities and on the dates indicated.</p>

<p style="font-family: &quot;Times New Roman&quot;; font-size: 10pt; margin: 0pt;">&nbsp;</p>

<table border="0" cellpadding="0" cellspacing="0" id="TBL14" style="width: 100%; text-indent: 0px; font-family: Times New Roman, Times, serif; font-size: 10pt;">

		<tr>
			<td style="width: 32%; text-align: center; vertical-align: middle; border-bottom-color: rgb(0, 0, 0); border-bottom-width: thin; border-bottom-style: solid;"><b>Signature</b></td>
			<td colspan="2" style="width: 2%; font-family: Times New Roman; font-size: 10pt; vertical-align: top;">&nbsp;</td>
			<td colspan="2" style="width: 32%; text-align: center; font-family: Times New Roman; font-size: 10pt; vertical-align: middle; border-bottom-color: rgb(0, 0, 0); border-bottom-width: thin; border-bottom-style: solid;"><b>Title</b></td>
			<td style="width: 2%; font-family: Times New Roman; font-size: 10pt; vertical-align: middle;">&nbsp;</td>
			<td colspan="1" style="width: 32%; text-align: center; font-family: Times New Roman; font-size: 10pt; vertical-align: middle; border-bottom-color: rgb(0, 0, 0); border-bottom-width: thin; border-bottom-style: solid;"><b>Date</b></td>
		</tr>
		<tr>
			<td style="width: 32%; vertical-align: middle; border-bottom-color: rgb(0, 0, 0); border-bottom-width: 1px; border-bottom-style: solid;">
			<p style="margin: 0pt; text-align: left; font-family: Times New Roman; font-size: 10pt;">&nbsp;</p>

			<p style="margin: 0pt; text-align: left; font-family: Times New Roman; font-size: 10pt;">/s/ Richard W. Pascoe</p>
			</td>
			<td colspan="2" style="width: 2%; font-family: Times New Roman; font-size: 10pt; vertical-align: top;">&nbsp;</td>
			<td colspan="2" style="width: 32%; font-family: Times New Roman; font-size: 10pt; vertical-align: middle;">&nbsp;</td>
			<td style="width: 2%; font-family: Times New Roman; font-size: 10pt; vertical-align: middle;">&nbsp;</td>
			<td colspan="1" style="width: 32%; font-family: Times New Roman; font-size: 10pt; vertical-align: middle;">&nbsp;</td>
		</tr>
		<tr>
			<td style="width: 32%; vertical-align: top; border-bottom-color: rgb(0, 0, 0); border-bottom-width: 1px; border-bottom-style: none;">
			<p style="margin: 0pt; text-align: left; font-family: Times New Roman; font-size: 10pt;">Richard W. Pascoe</p>
			</td>
			<td colspan="2" style="width: 2%; font-family: Times New Roman; font-size: 10pt; vertical-align: top;">&nbsp;</td>
			<td colspan="2" style="width: 32%; vertical-align: top;">
			<p style="margin: 0pt; text-align: center; font-size: 10pt;">Chief Executive Officer and Director</p>

			<div style="font-family: &quot;Times New Roman&quot;; text-align: center;"><i>(Principal Executive Officer)</i></div>
			</td>
			<td style="width: 2%; vertical-align: top;">&nbsp;</td>
			<td colspan="1" style="width: 32%; vertical-align: top;">
			<p style="margin: 0pt; text-align: center; font-family: Times New Roman; font-size: 10pt;">March 7, 2023</p>
			</td>
		</tr>
		<tr>
			<td style="width: 32%; vertical-align: middle; border-bottom-color: rgb(0, 0, 0); border-bottom-width: 1px; border-bottom-style: solid;">
			<p style="margin: 0pt; text-align: left; font-family: Times New Roman; font-size: 10pt;">/s/ R. LaDuane Clifton</p>
			</td>
			<td colspan="2" style="width: 2%; font-family: Times New Roman; font-size: 10pt; vertical-align: top;">&nbsp;</td>
			<td colspan="2" style="width: 32%; font-family: Times New Roman; font-size: 10pt; vertical-align: middle;">&nbsp;</td>
			<td style="width: 2%; font-family: Times New Roman; font-size: 10pt; vertical-align: middle;">&nbsp;</td>
			<td colspan="1" style="width: 32%; font-family: Times New Roman; font-size: 10pt; vertical-align: middle;">&nbsp;</td>
		</tr>
		<tr>
			<td style="width: 32%; vertical-align: top; border-bottom-color: rgb(0, 0, 0); border-bottom-width: 1px; border-bottom-style: none;">
			<p style="margin: 0pt; text-align: left; font-family: Times New Roman; font-size: 10pt;">R. LaDuane Clifton, CPA</p>
			</td>
			<td colspan="2" style="width: 2%; font-family: Times New Roman; font-size: 10pt; vertical-align: top;">&nbsp;</td>
			<td colspan="2" style="width: 32%; vertical-align: top;">
			<p style="margin: 0pt; text-align: center; font-family: Times New Roman; font-size: 10pt;">Chief Financial Officer, <font style="font-family: Times New Roman, Times, serif; font-size: 10pt;">Secretary and Treasurer</font></p>

			<p style="margin: 0pt; text-align: center; font-family: Times New Roman; font-size: 10pt;"><i>(Principal </i><font style="font-family: Times New Roman, Times, serif; font-size: 10pt;"><i>Financial </i><i>Officer)</i></font></p>
			</td>
			<td style="width: 2%; vertical-align: top;">&nbsp;</td>
			<td colspan="1" style="width: 32%; text-align: center; vertical-align: top;">March 7, 2023</td>
		</tr>
		<tr>
			<td style="width: 32%; vertical-align: middle; border-bottom-color: rgb(0, 0, 0); border-bottom-width: 1px; border-bottom-style: solid;">
			<p style="margin: 0pt; text-align: left; font-family: Times New Roman; font-size: 10pt;">/s/ Timothy J. Sangiovanni</p>
			</td>
			<td colspan="2" style="width: 2%; font-family: Times New Roman; font-size: 10pt; vertical-align: top;">&nbsp;</td>
			<td colspan="2" style="width: 32%; font-family: Times New Roman; font-size: 10pt; vertical-align: middle;">&nbsp;</td>
			<td style="width: 2%; font-family: Times New Roman; font-size: 10pt; vertical-align: middle;">&nbsp;</td>
			<td colspan="1" style="width: 32%; font-family: Times New Roman; font-size: 10pt; vertical-align: top;">&nbsp;</td>
		</tr>
		<tr>
			<td style="padding: 0px; width: 32%; vertical-align: top;">Timothy J. Sangiovanni, CPA</td>
			<td colspan="2" style="width: 2%; font-family: Times New Roman; font-size: 10pt; vertical-align: top;">&nbsp;</td>
			<td colspan="2" style="width: 32%; text-align: center; vertical-align: middle;">
			<p style="margin: 0pt; font-family: Times New Roman, Times, serif; font-size: 10pt;">Senior Vice President, Corporate Controller</p>

			<p style="margin: 0pt; font-family: Times New Roman, Times, serif; font-size: 10pt;"><i>(Principal Accounting Officer)</i></p>
			</td>
			<td style="width: 2%; vertical-align: middle;">&nbsp;</td>
			<td colspan="1" style="width: 32%; text-align: center; vertical-align: top;">March 7, 2023</td>
		</tr>
		<tr>
			<td style="width: 32%; vertical-align: middle; border-bottom-color: rgb(0, 0, 0); border-bottom-width: 1px; border-bottom-style: solid;">
			<p style="margin: 0pt; text-align: left; font-family: Times New Roman; font-size: 10pt;">&nbsp;</p>

			<p style="margin: 0pt; text-align: left; font-family: Times New Roman; font-size: 10pt;">/s/ Travis C. Mickle, Ph.D.</p>
			</td>
			<td colspan="2" style="width: 2%; font-family: Times New Roman; font-size: 10pt; vertical-align: top;">&nbsp;</td>
			<td colspan="2" style="width: 32%; font-family: Times New Roman; font-size: 10pt; vertical-align: middle;">&nbsp;</td>
			<td style="width: 2%; font-family: Times New Roman; font-size: 10pt; vertical-align: middle;">&nbsp;</td>
			<td colspan="1" style="width: 32%; font-family: Times New Roman; font-size: 10pt; vertical-align: top;">&nbsp;</td>
		</tr>
		<tr>
			<td style="width: 32%; vertical-align: top; border-bottom-color: rgb(0, 0, 0); border-bottom-width: 1px; border-bottom-style: none;">Travis C. Mickle, Ph.D.</td>
			<td colspan="2" style="width: 2%; font-family: Times New Roman; font-size: 10pt; vertical-align: top;">&nbsp;</td>
			<td colspan="2" style="width: 32%; vertical-align: top;">
			<p style="margin: 0pt; text-align: center; font-family: Times New Roman; font-size: 10pt;">President and Director</p>
			</td>
			<td style="width: 2%; vertical-align: top;">&nbsp;</td>
			<td colspan="1" style="width: 32%; text-align: center; vertical-align: top;">March 7, 2023</td>
		</tr>
		<tr>
			<td style="width: 32%; vertical-align: middle; border-bottom-color: rgb(0, 0, 0); border-bottom-width: 1px; border-bottom-style: solid;">
			<p style="margin: 0pt; text-align: left; font-family: Times New Roman; font-size: 10pt;">&nbsp;</p>

			<p style="margin: 0pt; text-align: left; font-family: Times New Roman; font-size: 10pt;">/s/Matthew R. Plooster</p>
			</td>
			<td colspan="2" style="width: 2%; font-family: Times New Roman; font-size: 10pt; vertical-align: top;">&nbsp;</td>
			<td colspan="2" style="width: 32%; font-family: Times New Roman; font-size: 10pt; vertical-align: middle;">&nbsp;</td>
			<td style="width: 2%; font-family: Times New Roman; font-size: 10pt; vertical-align: middle;">&nbsp;</td>
			<td colspan="1" style="width: 32%; font-family: Times New Roman; font-size: 10pt; vertical-align: top;">&nbsp;</td>
		</tr>
		<tr>
			<td style="width: 32%; vertical-align: top; border-bottom-color: rgb(0, 0, 0); border-bottom-width: 1px; border-bottom-style: none;">
			<p style="margin: 0pt; text-align: left; font-family: Times New Roman; font-size: 10pt;">Matthew R. Plooster</p>
			</td>
			<td colspan="2" style="width: 2%; font-family: Times New Roman; font-size: 10pt; vertical-align: top;">&nbsp;</td>
			<td colspan="2" style="width: 32%; vertical-align: top;">
			<p style="margin: 0pt; text-align: center; font-family: Times New Roman; font-size: 10pt;">Chairman of the Board of Directors</p>
			</td>
			<td style="width: 2%; vertical-align: top;">&nbsp;</td>
			<td colspan="1" style="width: 32%; text-align: center; vertical-align: top;">March 7, 2023</td>
		</tr>
		<tr>
			<td style="width: 32%; vertical-align: top;">&nbsp;</td>
			<td colspan="2" style="width: 2%; font-family: Times New Roman; font-size: 10pt; vertical-align: top;">&nbsp;</td>
			<td colspan="2" style="width: 32%; font-family: Times New Roman; font-size: 10pt; vertical-align: top;">&nbsp;</td>
			<td style="width: 2%; font-family: Times New Roman; font-size: 10pt; vertical-align: top;">&nbsp;</td>
			<td colspan="1" style="width: 32%; font-family: Times New Roman; font-size: 10pt; vertical-align: top;">&nbsp;</td>
		</tr>
		<tr>
			<td style="width: 32%; vertical-align: top; border-bottom: 1px solid rgb(0, 0, 0);">/s/ Tamara A. Favorito</td>
			<td colspan="2" style="width: 2%; font-family: Times New Roman; font-size: 10pt; vertical-align: top;">&nbsp;</td>
			<td colspan="2" style="width: 32%; font-family: &quot;Times New Roman&quot;; font-size: 10pt; vertical-align: top; text-align: center;">&nbsp;</td>
			<td style="width: 2%; font-family: Times New Roman; font-size: 10pt; vertical-align: top;">&nbsp;</td>
			<td colspan="1" style="width: 32%; font-family: &quot;Times New Roman&quot;; font-size: 10pt; vertical-align: top; text-align: center;">&nbsp;</td>
		</tr>
		<tr>
			<td style="width: 32%; vertical-align: top;">Tamara A. Favorito</td>
			<td colspan="2" style="width: 2%; font-family: Times New Roman; font-size: 10pt; vertical-align: top;">&nbsp;</td>
			<td colspan="2" style="width: 32%; font-family: &quot;Times New Roman&quot;; font-size: 10pt; vertical-align: top; text-align: center;">Director</td>
			<td style="width: 2%; font-family: Times New Roman; font-size: 10pt; vertical-align: top;">&nbsp;</td>
			<td colspan="1" style="width: 32%; font-family: &quot;Times New Roman&quot;; font-size: 10pt; vertical-align: top; text-align: center;">March 7, 2023</td>
		</tr>
		<tr>
			<td style="width: 32%; vertical-align: top; border-bottom-color: rgb(0, 0, 0); border-bottom-width: 1px; border-bottom-style: solid;">
			<p style="margin: 0pt; text-align: left; font-family: Times New Roman; font-size: 10pt;">&nbsp;</p>

			<p style="margin: 0pt; text-align: left; font-family: Times New Roman; font-size: 10pt;">/s/ Joseph B. Saluri</p>
			</td>
			<td colspan="2" style="width: 2%; font-family: Times New Roman; font-size: 10pt; vertical-align: top;">&nbsp;</td>
			<td colspan="2" style="width: 32%; font-family: Times New Roman; font-size: 10pt; vertical-align: top;">&nbsp;</td>
			<td style="width: 2%; font-family: Times New Roman; font-size: 10pt; vertical-align: top;">&nbsp;</td>
			<td colspan="1" style="width: 32%; font-family: Times New Roman; font-size: 10pt; vertical-align: top;">&nbsp;</td>
		</tr>
		<tr>
			<td style="width: 32%; vertical-align: top; border-bottom-color: rgb(0, 0, 0); border-bottom-width: 1px; border-bottom-style: none;">
			<p style="margin: 0pt; text-align: left; font-family: Times New Roman; font-size: 10pt;">Joseph B. Saluri</p>
			</td>
			<td colspan="2" style="width: 2%; font-family: Times New Roman; font-size: 10pt; vertical-align: top;">&nbsp;</td>
			<td colspan="2" style="width: 32%; vertical-align: top;">
			<p style="margin: 0pt; text-align: center; font-family: Times New Roman; font-size: 10pt;">Director</p>
			</td>
			<td style="width: 2%; vertical-align: top;">&nbsp;</td>
			<td colspan="1" style="width: 32%; text-align: center; vertical-align: top;">March 7, 2023</td>
		</tr>
		<tr>
			<td style="width: 32%; vertical-align: top; border-bottom-color: rgb(0, 0, 0); border-bottom-width: 1px; border-bottom-style: solid;">
			<p style="margin: 0pt; text-align: left; font-family: Times New Roman; font-size: 10pt;">&nbsp;</p>

			<p style="margin: 0pt; text-align: left; font-family: Times New Roman; font-size: 10pt;">/s/ David S. Tierney</p>
			</td>
			<td colspan="2" style="width: 2%; font-family: Times New Roman; font-size: 10pt; vertical-align: top;">&nbsp;</td>
			<td colspan="2" style="width: 32%; font-family: Times New Roman; font-size: 10pt; vertical-align: top;">&nbsp;</td>
			<td style="width: 2%; font-family: Times New Roman; font-size: 10pt; vertical-align: top;">&nbsp;</td>
			<td colspan="1" style="width: 32%; font-family: Times New Roman; font-size: 10pt; vertical-align: top;">&nbsp;</td>
		</tr>
		<tr>
			<td style="width: 32%; vertical-align: top; border-bottom-color: rgb(0, 0, 0); border-bottom-width: 1px; border-bottom-style: none;">
			<p style="margin: 0pt; text-align: left; font-family: Times New Roman; font-size: 10pt;">David <font style="font-family: Times New Roman, Times, serif; font-size: 10pt;">S. Tierney</font></p>
			</td>
			<td colspan="2" style="width: 2%; font-family: Times New Roman; font-size: 10pt; vertical-align: top;">&nbsp;</td>
			<td colspan="2" style="width: 32%; vertical-align: top;">
			<p style="margin: 0pt; text-align: center; font-family: Times New Roman; font-size: 10pt;">Director</p>
			</td>
			<td style="width: 2%; vertical-align: top;">&nbsp;</td>
			<td colspan="1" style="width: 32%; text-align: center; vertical-align: top;">March 7, 2023</td>
		</tr>
		<tr>
			<td style="width: 32%; vertical-align: top; border-bottom-color: rgb(0, 0, 0); border-bottom-width: 1px; border-bottom-style: none;">&nbsp;</td>
			<td colspan="2" style="width: 2%; font-family: Times New Roman; font-size: 10pt; vertical-align: top;">&nbsp;</td>
			<td colspan="2" style="width: 32%; vertical-align: top;">&nbsp;</td>
			<td style="width: 2%; vertical-align: top;">&nbsp;</td>
			<td colspan="1" style="width: 32%; text-align: center; vertical-align: top;">&nbsp;</td>
		</tr>
		<tr>
			<td style="width: 32%; vertical-align: top; border-bottom: 1px solid rgb(0, 0, 0);">/s/ Christopher Posner</td>
			<td colspan="2" style="width: 2%; font-family: Times New Roman; font-size: 10pt; vertical-align: top;">&nbsp;</td>
			<td colspan="2" style="width: 32%; vertical-align: top;">&nbsp;</td>
			<td style="width: 2%; vertical-align: top;">&nbsp;</td>
			<td colspan="1" style="width: 32%; text-align: center; vertical-align: top;">&nbsp;</td>
		</tr>
		<tr>
			<td style="width: 32%; vertical-align: top; border-bottom-color: rgb(0, 0, 0); border-bottom-width: 1px; border-bottom-style: none;">Christopher Posner</td>
			<td colspan="2" style="width: 2%; font-family: Times New Roman; font-size: 10pt; vertical-align: top;">&nbsp;</td>
			<td colspan="2" style="width: 32%; vertical-align: top; text-align: center;">Director</td>
			<td style="width: 2%; vertical-align: top;">&nbsp;</td>
			<td colspan="1" style="width: 32%; text-align: center; vertical-align: top;">March 7, 2023</td>
		</tr>

</table>

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[{"type": "S-8", "sequence": "1", "filename": "kmph20230217_s8.htm", "description": "FORM S-8", "secsgml_size_bytes": 47735}]
{"company-data": {"conformed-name": "ZEVRA THERAPEUTICS, INC.", "cik": "0001434647", "assigned-sic": "2834", "irs-number": "205894398", "state-of-incorporation": "DE", "fiscal-year-end": "1231"}, "filing-values": {"form-type": "S-8", "act": "33", "file-number": "333-270340", "film-number": "23714029"}, "business-address": {"street1": "1180 CELEBRATION BOULEVARD, SUITE 103", "city": "CELEBRATION", "state": "FL", "zip": "34747", "phone": "(321) 939-3416"}, "mail-address": {"street1": "1180 CELEBRATION BOULEVARD, SUITE 103", "city": "CELEBRATION", "state": "FL", "zip": "34747"}, "former-company": [{"former-conformed-name": "KEMPHARM, INC", "date-changed": "20130530"}, {"former-conformed-name": "KEMPHARM INC", "date-changed": "20080507"}]}
kmph20180110_s8.htm
As filed with the Securities and Exchange Commission on March 7
, 2023
Registration No. 333-
UNITED STATES
SECURITIES AND EXCHANGE COMMISSION
WASHINGTON, D.C. 20549
FORM S-8
REGISTRATION STATEMENT
UNDER
THE SECURITIES ACT OF 1933
Zevra Therapeutics, Inc.
(Exact Name of Registrant as Specified in Its Charter)
Delaware
20
-
5894398
(
State or Other Jurisdiction of
Incorporation or Organization)
(I.R.S. Employer
Identification No.)
1180 Celebration Boulevard, Suite
103
Celebration, FL 34747
(Address of Principal Executive Offices) (Zip Code)
Zevra Therapeutics, Inc.
Amended and Restated 2014 Equity Incentive Plan
(Full Title of the Plan)
R. LaDuane Clifton, CPA
Chief Financial Officer, Secretary and Treasurer
Zevra Therapeutics, Inc.
1180 Celebration Boulevard, Suite 103
Celebration, FL 34747
(Name and Address of Agent for Service)
(
321
) 939-3416
(Telephone Number, Including Area Code, of Agent for Service)
Copies to:
Nathan Ajiashvili, Esq.
Latham & Watkins LLP
1271 Avenue of the Americas
New York, NY 10020
(212) 906-1200
Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, a smaller reporting company or an emerging growth company. See the definitions of "large accelerated filer," "accelerated filer", "smaller reporting company" and "emerging growth company" in Rule 12b-2 of the Exchange Act.
Large accelerated filer ☐     Accelerated filer ☐     Non-accelerated filer ☒     Smaller reporting company ☒     Emerging growth company ☐
If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to
Section 7(a)(2)(B) of the Securities Act.  ☐
2
Explanatory Note
This Registration Statement on Form S-8 is being filed for the purpose of registering an
additional
2,781,837 shares of the Registrant's Common Stock to be issued pursuant to the Registrant's Amended and Restated 2014 Equity Incentive Plan (the
"
A&R 2014 Plan
"
). A Registration Statement of the Registrant on Form S-8 relating to the A&R 2014 Plan is effective.
INCORPORATION BY REFERENCE OF CONTENTS OF REGISTRATION
STATEMENTS ON FORM S-8
The contents of the Registration Statements on Form S-8 (File Nos.
333-203703
,
333-210369
,
333-216858
,
333-224062
,
333-230041
,
333-236794
,
333-252743
,
333-257429
), including any amendments thereto, as filed with the Securities and Exchange Commission (the "
Commission
"), are incorporated herein by reference and made a part of this Registration Statement.
3
ITEM
8.     EXHIBITS
Exhibit
Number
Description of the Exhibit
4
.1
Amended and Restated Certificate of Incorporation of the Registrant (incorporated by reference to Exhibit 3.1 to the Registrant's Current Report on Form 8-K (File No. 001-36913) filed on April 21, 2015)
4.2
Certificate of
Amendment of Amended and Restated Certificate of Incorporation of the Registrant, effective as of December 23, 2020 (incorporated by reference to Exhibit 3.1 to the Registrant's Current Report on Form 8-K (File No. 001-36913) filed on December 23, 2020)
4.3
Certificate of Amendment of Certificate of Incorporation of the Registrant, effective as of February 21, 2023 (incorporated by reference to Exhibit 3.1 to the Registrant's Current Report on Form 8-K (File No. 001-36913) filed on February 24, 2023)
4.4
Amended and Restated Bylaws of the Registrant (incorporated by reference to Exhibit 3.2 to the Registrant's Current Report on Form 8-K (File No. 001-36913) filed on February 24, 2023)
5.1*
Opinion of Latham and Watkins LLP
23.1*
Consent of Ernst & Young
LLP, Independent Registered Public Accounting Firm.
23.2*
Consent of RSM US LLP, Independent Registered Public Accounting Firm.
23.3*
Consent of Latham & Watkins LLP (included in Exhibit 5.1).
24.1
Power of Attorney (included on the signature page).
99.1
Amended and Restated 2014 Equity Incentive Plan (incorporated by reference to Exhibit 10.4 to the Registrant
'
s Quarterly Report on Form 10-Q (File No. 36913) filed on August 13, 2021)
99.2
Form of Stock Option Grant Notice and Stock Option Agreement under 2014 Equity Incentive Plan (incorporated herein by reference to Exhibit 10.15 to the Registrant's Registration Statement on Form S-1 (File No. 333-202660) filed on March 11, 2015)
99.3
Form of Restricted Stock Unit Grant Notice and Restricted Stock Unit Award Agreement under 2014 Equity Incentive Plan (incorporated herein by reference to Exhibit 10.16 to the Registrant's Registration Statement on Form S-1 (File No. 333-202660) filed on March 11, 2015)
107.1*
Filing Fee Table
* Filed herewith
4
SIGNATURES
Pursuant to the requirements of the Securities Act of 1933, as amended, the Registrant certifies that it has reasonable grounds to believe that it meets all of the requirements for filing on Form
S-8 and has duly caused this Registration Statement to be signed on its behalf by the undersigned, thereunto duly authorized, in the City of Celebration, State of Florida, on this 7th day of March, 2023.
Zevra Therapeutics, Inc.
By:
/s/ R. LaDuane Clifton
R. LaDuane Clifton, CPA
Chief Financial Officer, Secretary and Treasurer
5
POWER OF ATTORNEY
KNOW ALL BY THESE PRESENTS, that each person whose signature appears below hereby constitutes and appoints Richard W. Pascoe
. and R. LaDuane Clifton, CPA and each or any one of them, his lawful attorney-in-fact and agent, with full power of substitution and resubstitution, for him and in his name, place and stead, in any and all capacities, to sign any and all amendments (including post-effective amendments) to this Registration Statement, and to file the same, with all exhibits thereto, and other documents in connection therewith, with the Securities and Exchange Commission, granting unto said attorneys-in-fact and agents, and each of them, full power and authority to do and perform each and every act and thing requisite and necessary to be done in connection therewith, as fully to all intents and purposes as he might or could do in person, hereby ratifying and confirming all that said attorneys-in-fact and agents, or any of them, or their or his substitutes or substitute, may lawfully do or cause to be done by virtue hereof.
Pursuant to the requirements of the Securities Act of 1933, as amended, this Registration Statement has been signed by the following persons in the capacities and on the dates indicated.
Signature
Title
Date
/s/ Richard W. Pascoe
Richard W. Pascoe
Chief Executive Officer and Director
(Principal Executive Officer)
March 7, 2023
/s/ R. LaDuane Clifton
R. LaDuane Clifton, CPA
Chief Financial Officer,
Secretary and Treasurer
(Principal
Financial
Officer)
March 7, 2023
/s/ Timothy J. Sangiovanni
Timothy J. Sangiovanni, CPA
Senior Vice President, Corporate Controller
(Principal Accounting Officer)
March 7, 2023
/s/ Travis C. Mickle, Ph.D.
Travis C. Mickle, Ph.D.
President and Director
March 7, 2023
/s/Matthew R. Plooster
Matthew R. Plooster
Chairman of the Board of Directors
March 7, 2023
/s/ Tamara A. Favorito
Tamara A. Favorito
Director
March 7, 2023
/s/ Joseph B. Saluri
Joseph B. Saluri
Director
March 7, 2023
/s/ David S. Tierney
David
S. Tierney
Director
March 7, 2023
/s/ Christopher Posner
Christopher Posner
Director
March 7, 2023
6