<HTML>
<HEAD>
<TITLE>Registration statement</TITLE>
</HEAD>
<BODY bgcolor="#FFFFFF">
<!-- PAGEBREAK -->
<H5 align="left" style="page-break-before:always">&nbsp;</H5><P>
<DIV style="font-family: 'Times New Roman',Times,serif">


<DIV style="width: 100%; border-bottom: 2pt solid black; font-size: 1pt">&nbsp;</DIV>
<DIV style="width: 100%; border-bottom: 1pt solid black; font-size: 1pt">&nbsp;</DIV>




<DIV align="center" style="font-size: 14pt; margin-top: 12pt"><B>UNITED STATES<BR>
SECURITIES AND EXCHANGE COMMISSION</B>
</DIV>

<DIV align="center" style="font-size: 12pt"><B>Washington, D.C. 20549</B>
</DIV>

<DIV align="center" style="font-size: 18pt; margin-top: 15pt"><B>FORM S-8</B>
</DIV>


<DIV align="center" style="font-size: 11pt; margin-top: 15pt"><B>REGISTRATION STATEMENT<BR>
UNDER<BR>
THE SECURITIES ACT OF 1933</B>
</DIV>

<DIV align="center" style="font-size: 24pt; margin-top: 15pt"><B>CARDIOME PHARMA CORP.</B>
</DIV>

<DIV align="center" style="font-size: 10pt">(Exact name of registrant as specified in its charter)</DIV>


<DIV align="center" style="margin-top: 12pt">
<TABLE style="font-size: 10pt" cellspacing="0" border="0" cellpadding="0" width="85%">
<!-- Begin Table Head -->
<TR valign="bottom">
    <TD width="35%">&nbsp;</TD>
    <TD width="30%">&nbsp;</TD>
    <TD width="35%">&nbsp;</TD>
</TR>
<!-- End Table Head -->
<!-- Begin Table Body -->
<TR valign="bottom">
    <TD align="center"><DIV style="margin-left:30px; text-indent:-15px"><B>Canada</B></DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="center" valign="top"><B>Not applicable</B></TD>
</TR>
<TR valign="middle">
    <TD align="center"><DIV style="margin-left:15px; text-indent:-15px"><DIV style="width: 100%; border-bottom: 1px solid #000000; font-size: 1px">&nbsp;</DIV></DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="center"><DIV style="width: 100%; border-bottom: 1px solid #000000; font-size: 1px">&nbsp;</DIV></TD>
</TR>
<TR valign="top">
    <TD align="center"><DIV style="margin-left:15px; text-indent:-15px">(State or other jurisdiction of<BR></DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="center" valign="top">(IRS Employer Identification No.)<BR></TD>
</TR>
<TR valign="bottom">
    <TD align="center"><DIV style="margin-left:15px; text-indent:-15px">incorporation or organization)</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="center" valign="top">&nbsp;</TD>
</TR>
<!-- End Table Body -->
</TABLE>
</DIV>


<DIV align="center" style="font-size: 10pt; margin-top: 18pt"><B>6th Floor, 6190 Agronomy Road<BR>
Vancouver, British Columbia<BR>
Canada V6T 1Z3<BR>
(604)&nbsp;677-6905</B><BR>
(Address of registrant&#146;s Principal Executive Offices)
</DIV>


<DIV align="center" style="font-size: 10pt; margin-top: 18pt"><B>AMENDED 2001 INCENTIVE STOCK OPTION PLAN</B><BR>
(Full title of the plan)
</DIV>


<DIV align="center" style="font-size: 10pt; margin-top: 18pt">PTSGE Corp.<BR>
925 Fourth Avenue, Suite&nbsp;2900<BR>
Seattle, Washington 98104<BR>
(206)&nbsp;623-7580<BR>
(Name, address, including ZIP code, and telephone number, including area code, of agent for service)
</DIV>


<DIV align="center" style="font-size: 10pt; margin-top: 18pt">Copies to:<BR>
Annette E. Becker, Esq.<BR>
Devin W. Stockfish, Esq.<BR>
Kirkpatrick &#038; Lockhart Preston Gates Ellis LLP<BR>
925 Fourth Avenue, Suite&nbsp;2900<BR>
Seattle, WA 98104<BR>
(206)&nbsp;623-7580
</DIV>


<DIV align="center" style="font-size: 10pt; margin-top: 18pt"><B>CALCULATION OF REGISTRATION FEE</B>
</DIV>

<DIV align="center">
<TABLE style="font-size: 10pt" cellspacing="0" border="0" cellpadding="0" width="100%">
<!-- Begin Table Head -->
<TR style="font-size: 1pt" valign="bottom">
    <TD width="1%">&nbsp;</TD>
    <TD width="36%">&nbsp;</TD>
    <TD width="3%">&nbsp;</TD><!-- VRule -->
    <TD width="2%">&nbsp;</TD>
    <TD width="14%">&nbsp;</TD>
    <TD width="3%">&nbsp;</TD><!-- VRule -->
    <TD width="2%">&nbsp;</TD>
    <TD width="7%">&nbsp;</TD>
    <TD width="3%">&nbsp;</TD><!-- VRule -->
    <TD width="2%">&nbsp;</TD>
    <TD width="7%">&nbsp;</TD>
    <TD width="3%">&nbsp;</TD><!-- VRule -->
    <TD width="2%">&nbsp;</TD>
    <TD width="14%">&nbsp;</TD>

    <TD width="1%">&nbsp;</TD>
</TR><TR style="font-size: 1px" valign="bottom">
    <TD nowrap align="left" colspan="15" style="border-bottom: 3px double #000000">&nbsp;</TD>
</TR>
<TR style="font-size: 8pt" valign="bottom">    <TD width="1%">&nbsp;</TD>

    <TD nowrap align="left">Title of each class of</TD>
    <TD style="border-right: 2px solid #000000">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD nowrap align="center">Amount to be</TD>
    <TD style="border-right: 2px solid #000000">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD nowrap align="center">Proposed maximum</TD>
    <TD style="border-right: 2px solid #000000">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD nowrap align="center">Proposed maximum</TD>
    <TD style="border-right: 2px solid #000000">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD nowrap align="center">Amount of</TD>
    <TD width="1%">&nbsp;</TD>
</TR>
<TR style="font-size: 8pt" valign="bottom">    <TD width="1%">&nbsp;</TD>

    <TD nowrap align="left">securities to be registered</TD>
    <TD style="border-right: 2px solid #000000">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD nowrap align="center">registered (1)</TD>
    <TD style="border-right: 2px solid #000000">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD nowrap align="center">offering price per share (2)</TD>
    <TD style="border-right: 2px solid #000000">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD nowrap align="center">aggregate offering price</TD>
    <TD style="border-right: 2px solid #000000">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD nowrap align="center">registration fee</TD>
    <TD width="1%">&nbsp;</TD>
</TR>

<!-- End Table Head -->
<!-- Begin Table Body -->
<TR valign="bottom">
    <TD width="1%" style="border-top: 2px solid #000000">&nbsp;</TD>
    <TD valign="top" style="border-top: 2px solid #000000"><DIV style="margin-left:0px; text-indent:-0px">Common Shares, without par value
</DIV></TD>
    <TD style="border-right: 2px solid #000000; border-top: 2px solid #000000">&nbsp;</TD>
    <TD style="border-top: 2px solid #000000">&nbsp;</TD>
    <TD align="center" valign="top" style="border-top: 2px solid #000000">350,000 shares
</TD>
    <TD style="border-right: 2px solid #000000; border-top: 2px solid #000000">&nbsp;</TD>
    <TD style="border-top: 2px solid #000000">&nbsp;</TD>

<TD align="center" valign="top" style="border-top: 2px solid #000000">$8.76
</TD>
    <TD style="border-right: 2px solid #000000; border-top: 2px solid #000000">&nbsp;</TD>
    <TD style="border-top: 2px solid #000000">&nbsp;</TD>

<TD align="center" valign="top" style="border-top: 2px solid #000000">$3,066,000
</TD>
    <TD style="border-right: 2px solid #000000; border-top: 2px solid #000000">&nbsp;</TD>
    <TD style="border-top: 2px solid #000000">&nbsp;</TD>

<TD align="center" valign="top" style="border-top: 2px solid #000000">$94.13</TD>
    <TD width="1%" style="border-top: 2px solid #000000">&nbsp;</TD>
</TR>
<TR style="font-size: 1px" valign="bottom">
    <TD nowrap align="left" colspan="15" style="border-top: 3px double #000000">&nbsp;</TD>
</TR>

<!-- End Table Body -->
</TABLE>
</DIV>


<DIV align="center" style="margin-top: 3pt">
<TABLE width="100%" border="0" cellpadding="0" cellspacing="0" style="font-size: 10pt">
<TR>
    <TD width="3%"></TD>
    <TD width="1%"></TD>
    <TD width="96"></TD>
</TR>

<TR valign="top">
    <TD nowrap align="left">(1)</TD>
    <TD>&nbsp;</TD>
    <TD>Pursuant to Rule&nbsp;416(a), this Registration Statement shall also cover
any additional common shares of the registrant that become issuable
under the Amended 2001 Incentive Stock Option Plan by reason of any
stock dividend, stock split, recapitalization or other similar
transaction effected without receipt of consideration that increases
the number of outstanding common shares of the registrant.</TD>
</TR>

<TR style="font-size: 3pt"><TD>&nbsp;</TD></TR>

<TR valign="top">
    <TD nowrap align="left">(2)</TD>
    <TD>&nbsp;</TD>
    <TD>Computed in accordance with Rule 457(h) and Rule&nbsp;457(c), solely for
the purpose of calculating the registration fee, based on the average
of the high and low prices of the common shares of the registrant as
reported by The Nasdaq Stock Market on September 12, 2007.</TD>
</TR>
</TABLE>
</DIV>


<DIV style="width: 100%; border-bottom: 1pt solid black; margin-top: 10pt; font-size: 1pt">&nbsp;</DIV>
<DIV style="width: 100%; border-bottom: 2pt solid black; font-size: 1pt">&nbsp;</DIV>



<P align="center" style="font-size: 10pt"><!-- Folio -->&nbsp;<!-- /Folio -->
</DIV>

<!-- PAGEBREAK -->
<P><HR noshade><P>
<H5 align="left" style="page-break-before:always">&nbsp;</H5><P>

<DIV style="font-family: 'Times New Roman',Times,serif">








<DIV align="center" style="font-size: 10pt; margin-top: 18pt"><B>EXPLANATORY NOTE</B>
</DIV>


<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;This Registration Statement is being filed pursuant to General Instruction E of Form S-8 to
register an additional 350,000 common<BR>shares of registrant, which may be issued under the
registrant&#146;s Amended 2001 Incentive Stock Option Plan, as amended September&nbsp;5, 2007. Such shares
are additional securities of the same class as other securities for which previous registration
statements on Form S-8 were filed with the Securities and Exchange Commission (the &#147;Commission&#148;) on
June&nbsp;16, 2005 (File&nbsp;No.&nbsp;333-125860) and
August&nbsp;17, 2006 (File&nbsp;No.&nbsp;333-136696). Pursuant to General
Instruction E of Form S-8, the contents of the above listed registration statements are
incorporated by reference herein.
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 12pt"><B>Item&nbsp;3.&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Incorporation of Documents by Reference.</B>
</DIV>


<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;The following documents heretofore filed with the Commission by the registrant are
incorporated herein by reference:
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(a)&nbsp;&nbsp;&nbsp;The registrant&#146;s Annual Report on Form 40-F for the fiscal year ended December&nbsp;31, 2006.
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(b)&nbsp;&nbsp;&nbsp;The registrant&#146;s reports on Form 6-K filed with the Commission on January&nbsp;18, 2007,
January&nbsp;19, 2007, January&nbsp;23, 2007, February&nbsp;9, 2007, February&nbsp;20, 2007, February&nbsp;22, 2007, March
13, 2007, March&nbsp;29, 2007, May&nbsp;10, 2007, May&nbsp;14, 2007, May&nbsp;14, 2007, May&nbsp;18, 2007, May&nbsp;30, 2007,
June&nbsp;4, 2007, June&nbsp;19, 2007, August&nbsp;9, 2007, August&nbsp;10, 2007, August&nbsp;10, 2007, and August&nbsp;30, 2007.
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(c)&nbsp;&nbsp;&nbsp;The description of the registrant&#146;s common shares contained in the Registration Statement
on Form 20-F filed with the Commission on August&nbsp;22, 1997 including any amendments or reports filed
for the purpose of updating such description.
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;All documents subsequently filed by the registrant with the Commission pursuant to Sections
13(a), 13(c), 14 and 15(d) of the Exchange Act, prior to the filing of a post-effective amendment
to this Registration Statement that indicates that all securities offered hereby have been sold or
which deregisters all securities then remaining unsold, shall be deemed to be incorporated in this
Registration Statement by reference and to be a part hereof from the date of filing of such
documents, other than information in the documents that is not deemed to be filed with the
Commission.
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Any statement contained herein or in a document incorporated or deemed to be incorporated by
reference herein, shall be deemed to be modified or superseded for purposes of this Registration
Statement to the extent that a statement contained in any subsequently filed document which is
incorporated by reference herein, modifies or supersedes the statement. Any statements so modified
or superseded shall not be deemed, except as so modified or superseded, to constitute a part of
this Registration Statement.
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 12pt"><B>Item&nbsp;8.&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Exhibits.</B>
</DIV>


<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;The Exhibits to this Registration Statement are listed in the Index to Exhibits on the page
following the signature page to this Registration Statement.
</DIV>

<P align="center" style="font-size: 10pt"><!-- Folio -->&nbsp;<!-- /Folio -->
</DIV>

<!-- PAGEBREAK -->
<P><HR noshade><P>
<H5 align="left" style="page-break-before:always">&nbsp;</H5><P>

<DIV style="font-family: 'Times New Roman',Times,serif">

<DIV align="center" style="font-size: 10pt; margin-top: 18pt"><B>SIGNATURES</B>
</DIV>


<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Pursuant to the requirements of the Securities Act of 1933, the registrant certifies that it
has reasonable grounds to believe that it meets all of the requirements for filing on Form S-8 and
has duly caused this Registration Statement to be signed on its behalf by the undersigned,
thereunto duly authorized, in the City of Vancouver, Province of
British Columbia, on the 14th day
of September, 2007.
</DIV>

<TABLE width="100%" border="0" cellspacing="0" cellpadding="0" style="font-size: 10pt">
<TR>
    <TD width="48%">&nbsp;</TD>
    <TD width="1%">&nbsp;</TD>
    <TD width="1%">&nbsp;</TD>
    <TD width="35%">&nbsp;</TD>
    <TD width="15%">&nbsp;</TD>
</TR>
<TR>
    <TD valign="top" align="left">&nbsp;</TD>
    <TD colspan="3" align="left">&nbsp;<BR><B>CARDIOME PHARMA CORP.</B> <BR>
&nbsp;<BR>
&nbsp;</TD>
    <TD>&nbsp;</TD>
</TR><TR>
    <TD align="left">&nbsp;</TD>
    <TD valign="top">By:&nbsp;&nbsp;</TD>
    <TD colspan="2" style="border-bottom: 1px solid #000000" align="left">/s/&nbsp;&nbsp;ROBERT W. RIEDER
&nbsp;</TD>
    <TD>&nbsp;</TD>
</TR><TR>
    <TD align="left">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD colspan="2" align="left">Robert W. Rieder, Chief Executive Officer      &nbsp;</TD>
    <TD>&nbsp;</TD>
</TR><TR>
    <TD align="left">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD colspan="2" align="left">&nbsp;</TD>
    <TD>&nbsp;</TD>
</TR>
<TR>
    <TD colspan="5">&nbsp;</TD>
</TR>
</TABLE>

<DIV align="center" style="font-size: 10pt; margin-top: 18pt"><B>POWER OF ATTORNEY</B>
</DIV>



<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;KNOW ALL PERSONS BY THESE PRESENTS, that each person whose signature appears below constitutes
and appoints Robert W. Rieder and Douglas G. Janzen, jointly and severally, each in his own
capacity, his true and lawful attorneys-in-fact, with full power of substitution, for him and his
name, place and stead, in any and all capacities, to sign any and all amendments (including
post-effective amendments) to this registration statement, and to file the same, with all exhibits
thereto and other documents in connection therewith, with the Securities and Exchange Commission,
granting unto such said attorneys-in-fact and agents with full power and authority to do so and
perform each and every act and thing requisite and necessary to be done in and about the premises,
as fully to all intents and purposes as he might or could do in person, hereby ratifying and
confirming all that said attorneys-in-fact, or their substitute or substitutes, may lawfully do or
cause to be done by virtue hereof.
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Pursuant to the requirements of the Securities Act of 1933, this Registration Statement has
been signed by the following persons in the capacities indicated on
September 14, 2007.
</DIV>
<DIV align="center" style="margin-top: 12pt">
<TABLE style="font-size: 10pt" cellspacing="0" border="0" cellpadding="0" width="100%">
<!-- Begin Table Head -->
<TR valign="bottom">
    <TD width="40%">&nbsp;</TD>
    <TD width="5%">&nbsp;</TD>
    <TD width="55%">&nbsp;</TD>
</TR>
<!-- End Table Head -->
<!-- Begin Table Body -->
<TR valign="bottom">
    <TD align="center" nowrap valign="top">/s/&nbsp;&nbsp;ROBERT W. RIEDER
<DIV style="font-size: 1pt; border-bottom: 1px solid #000000">&nbsp;</DIV>
Robert W. Rieder</TD>
    <TD>&nbsp;</TD>
    <TD align="left">Chief Executive Officer and Chairman of the Board of Directors<BR>
(Principal Executive Officer)</TD>
</TR>
<TR valign="bottom" style="padding-top: 1em"><!-- Blank Space -->
    <TD align="right">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD align="center" nowrap valign="top">&nbsp;</TD>
</TR>
<TR valign="bottom" style="padding-top: 1em">
    <TD align="center" nowrap valign="top">/s/&nbsp;&nbsp;CURTIS SIKORSKY
<DIV style="font-size: 1pt; border-bottom: 1px solid #000000">&nbsp;</DIV>
Curtis Sikorsky</TD>
    <TD>&nbsp;</TD>
    <TD align="left">Chief Financial Officer (Principal Financial Officer and<BR>
Principal Accounting Officer)</TD>
</TR>
<TR valign="bottom" style="padding-top: 1em"><!-- Blank Space -->
    <TD align="right">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD align="center" nowrap valign="top">&nbsp;</TD>
</TR>
<TR valign="top" style="padding-top: 1em">
    <TD align="center" nowrap valign="top">/s/&nbsp;&nbsp;RICHARD M. GLICKMAN
<DIV style="font-size: 1pt; border-bottom: 1px solid #000000">&nbsp;</DIV>
Richard M. Glickman</TD>
    <TD>&nbsp;</TD>
    <TD align="left">Director</TD>
</TR>
<TR valign="bottom" style="padding-top: 1em"><!-- Blank Space -->
    <TD align="right">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD align="center" nowrap valign="top">&nbsp;</TD>
</TR>
<TR valign="top" style="padding-top: 1em">
    <TD align="center" nowrap valign="top">/s/&nbsp;&nbsp;JACKIE M. CLEGG
<DIV style="font-size: 1pt; border-bottom: 1px solid #000000">&nbsp;</DIV>
Jackie M. Clegg</TD>
    <TD>&nbsp;</TD>
    <TD align="left">Director</TD>
</TR>
<TR valign="bottom" style="padding-top: 1em"><!-- Blank Space -->
    <TD align="right">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD align="center" nowrap valign="top">&nbsp;</TD>
</TR>
<TR valign="top" style="padding-top: 1em">
    <TD align="center" nowrap valign="top">/s/&nbsp;&nbsp;HAROLD H. SHLEVIN
<DIV style="font-size: 1pt; border-bottom: 1px solid #000000">&nbsp;</DIV>
Harold H. Shlevin</TD>
    <TD>&nbsp;</TD>
    <TD align="left">Director</TD>
</TR>
<TR valign="top" style="padding-top: 1em"><!-- Blank Space -->
    <TD align="right">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD align="center" nowrap valign="top">&nbsp;</TD>
</TR>
<TR valign="top" style="padding-top: 1em">
    <TD align="center" nowrap valign="top">/s/&nbsp;&nbsp;PETER W. ROBERTS
<DIV style="font-size: 1pt; border-bottom: 1px solid #000000">&nbsp;</DIV>
Peter W. Roberts</TD>
    <TD>&nbsp;</TD>
    <TD align="left">Director</TD>
</TR>
<TR valign="bottom" style="padding-top: 1em"><!-- Blank Space -->
    <TD align="right">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD align="center" nowrap valign="top">&nbsp;</TD>
</TR>
<TR valign="top" style="padding-top: 1em">
    <TD align="center" nowrap valign="top">/s/&nbsp;&nbsp;DOUGLAS G. JANZEN
<DIV style="font-size: 1pt; border-bottom: 1px solid #000000">&nbsp;</DIV>
Douglas G. Janzen</TD>
    <TD>&nbsp;</TD>
    <TD align="left">Director</TD>
</TR>
<TR valign="bottom" style="padding-top: 1em"><!-- Blank Space -->
    <TD align="right">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD align="center" nowrap valign="top">&nbsp;</TD>
</TR>
<TR valign="top" style="padding-top: 1em">
    <TD align="center" nowrap valign="top">/s/&nbsp;&nbsp;WILLIAM L. HUNTER
<DIV style="font-size: 1pt; border-bottom: 1px solid #000000">&nbsp;</DIV>
William L. Hunter</TD>
    <TD>&nbsp;</TD>
    <TD align="left">Director</TD>
</TR>
<TR valign="top" style="padding-top: 1em"><!-- Blank Space -->
    <TD align="right">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD align="center" nowrap valign="top">&nbsp;</TD>
</TR>
<TR valign="top" style="padding-top: 1em">
    <TD align="center" nowrap valign="top">/s/&nbsp;&nbsp;CHARLES
FISHER
<DIV style="font-size: 1pt; border-bottom: 1px solid #000000">&nbsp;</DIV>
Charles Fisher</TD>
    <TD>&nbsp;</TD>
    <TD align="left">Authorized Representative in the United States</TD>
</TR>
<!-- End Table Body -->
</TABLE>
</DIV>



<P align="center" style="font-size: 10pt"><!-- Folio -->&nbsp;<!-- /Folio -->
</DIV>

<!-- PAGEBREAK -->
<P><HR noshade><P>
<H5 align="left" style="page-break-before:always">&nbsp;</H5><P>

<DIV style="font-family: 'Times New Roman',Times,serif">




<DIV align="center" style="font-size: 10pt; margin-top: 18pt"><B>INDEX TO EXHIBITS</B>
</DIV>

<DIV align="center" style="margin-top: 6pt">
<TABLE style="font-size: 10pt" cellspacing="0" border="0" cellpadding="0" width="85%">
<!-- Begin Table Head -->
<TR valign="bottom">
    <TD width="6%">&nbsp;</TD>
    <TD width="4%">&nbsp;</TD>
    <TD width="90%">&nbsp;</TD>
</TR>
<TR style="font-size: 8pt" valign="bottom">
    <TD nowrap align="center">Exhibit</TD>
    <TD>&nbsp;</TD>
    <TD nowrap align="center">&nbsp;</TD>
</TR>
<TR style="font-size: 8pt" valign="bottom">
    <TD nowrap align="center" style="border-bottom: 1px solid #000000">Number</TD>
    <TD>&nbsp;</TD>
    <TD nowrap align="left" style="border-bottom: 1px solid #000000">Description</TD>
</TR>
<TR valign="bottom"><!-- Blank Space -->
    <TD align="center" valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">&nbsp;</TD>
</TR>
<!-- End Table Head -->
<!-- Begin Table Body -->
<TR valign="bottom">
    <TD align="center" valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;&nbsp;5.1
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">Opinion of McCarthy T&#233;trault LLP</TD>
</TR>
<TR valign="bottom"><!-- Blank Space -->
    <TD align="center" valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">&nbsp;</TD>
</TR>
<TR valign="bottom">
    <TD align="center" valign="top"><DIV style="margin-left:0px; text-indent:-0px">23.1
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">Consent of KPMG LLP, Chartered Accountants</TD>
</TR>
<TR valign="bottom"><!-- Blank Space -->
    <TD align="center" valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">&nbsp;</TD>
</TR>
<TR valign="bottom">
    <TD align="center" valign="top"><DIV style="margin-left:0px; text-indent:-0px">23.2
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">Consent of Ernst &#038; Young LLP, Chartered Accountants</TD>
</TR>
<TR valign="bottom"><!-- Blank Space -->
    <TD align="center" valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">&nbsp;</TD>
</TR>
<TR valign="bottom">
    <TD align="center" valign="top"><DIV style="margin-left:0px; text-indent:-0px">23.3
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">Consent of McCarthy T&#233;trault LLP (included in Exhibit&nbsp;5.1)</TD>
</TR>
<TR valign="bottom"><!-- Blank Space -->
    <TD align="center" valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">&nbsp;</TD>
</TR>
<TR valign="bottom">
    <TD align="center" valign="top"><DIV style="margin-left:0px; text-indent:-0px">24.1
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">Power of Attorney (included as part of the signature page to this Registration Statement)</TD>
</TR>
<TR valign="bottom"><!-- Blank Space -->
    <TD align="center" valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">&nbsp;</TD>
</TR>
<TR valign="bottom">
    <TD align="center" valign="top"><DIV style="margin-left:0px; text-indent:-0px">99.1
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">Cardiome Pharma Corp. Amended 2001 Incentive Stock Option Plan</TD>
</TR>
<!-- End Table Body -->
</TABLE>
</DIV>


<P align="center" style="font-size: 10pt"><!-- Folio -->&nbsp;<!-- /Folio -->
</DIV>

</BODY>
</HTML>
[{"type": "S-8", "sequence": "1", "filename": "o37677sv8.htm", "description": "FORM S-8", "secsgml_size_bytes": 24774}]
{"company-data": {"conformed-name": "Cardiome Pharma Corp", "cik": "0001036141", "assigned-sic": "2834", "irs-number": "000000000", "state-of-incorporation": "A1", "fiscal-year-end": "1231"}, "filing-values": {"form-type": "S-8", "act": "33", "file-number": "333-146091", "film-number": "071118254"}, "business-address": {"street1": "6TH FLOOR", "street2": "6190 AGRONOMY RD.", "city": "VANCOUVER", "state": "A1", "zip": "V6T 1Z3", "phone": "1-604-677-6905"}, "mail-address": {"street1": "6TH FLOOR", "street2": "6190 AGRONOMY RD.", "city": "VANCOUVER", "state": "A1", "zip": "V6T 1Z3"}, "former-company": {"former-conformed-name": "CARDIOME PHARMA CORP", "date-changed": "20000407"}}
Registration statement
UNITED STATES
SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM S-8
REGISTRATION STATEMENT
UNDER
THE SECURITIES ACT OF 1933
CARDIOME PHARMA CORP.
(Exact name of registrant as specified in its charter)
Canada
Not applicable
(State or other jurisdiction of
(IRS Employer Identification No.)
incorporation or organization)
6th Floor, 6190 Agronomy Road
Vancouver, British Columbia
Canada V6T 1Z3
(604) 677-6905
(Address of registrant's Principal Executive Offices)
AMENDED 2001 INCENTIVE STOCK OPTION PLAN
(Full title of the plan)
PTSGE Corp.
925 Fourth Avenue, Suite 2900
Seattle, Washington 98104
(206) 623-7580
(Name, address, including ZIP code, and telephone number, including area code, of agent for service)
Copies to:
Annette E. Becker, Esq.
Devin W. Stockfish, Esq.
Kirkpatrick & Lockhart Preston Gates Ellis LLP
925 Fourth Avenue, Suite 2900
Seattle, WA 98104
(206) 623-7580
CALCULATION OF REGISTRATION FEE
Title of each class of
Amount to be
Proposed maximum
Proposed maximum
Amount of
securities to be registered
registered (1)
offering price per share (2)
aggregate offering price
registration fee
Common Shares, without par value
350,000 shares
$8.76
$3,066,000
$94.13
(1)
Pursuant to Rule 416(a), this Registration Statement shall also cover
any additional common shares of the registrant that become issuable
under the Amended 2001 Incentive Stock Option Plan by reason of any
stock dividend, stock split, recapitalization or other similar
transaction effected without receipt of consideration that increases
the number of outstanding common shares of the registrant.
(2)
Computed in accordance with Rule 457(h) and Rule 457(c), solely for
the purpose of calculating the registration fee, based on the average
of the high and low prices of the common shares of the registrant as
reported by The Nasdaq Stock Market on September 12, 2007.
EXPLANATORY NOTE
This Registration Statement is being filed pursuant to General Instruction E of Form S-8 to
register an additional 350,000 common
shares of registrant, which may be issued under the
registrant's Amended 2001 Incentive Stock Option Plan, as amended September 5, 2007. Such shares
are additional securities of the same class as other securities for which previous registration
statements on Form S-8 were filed with the Securities and Exchange Commission (the "Commission") on
June 16, 2005 (File No. 333-125860) and
August 17, 2006 (File No. 333-136696). Pursuant to General
Instruction E of Form S-8, the contents of the above listed registration statements are
incorporated by reference herein.
Item 3.     Incorporation of Documents by Reference.
The following documents heretofore filed with the Commission by the registrant are
incorporated herein by reference:
(a)   The registrant's Annual Report on Form 40-F for the fiscal year ended December 31, 2006.
(b)   The registrant's reports on Form 6-K filed with the Commission on January 18, 2007,
January 19, 2007, January 23, 2007, February 9, 2007, February 20, 2007, February 22, 2007, March
13, 2007, March 29, 2007, May 10, 2007, May 14, 2007, May 14, 2007, May 18, 2007, May 30, 2007,
June 4, 2007, June 19, 2007, August 9, 2007, August 10, 2007, August 10, 2007, and August 30, 2007.
(c)   The description of the registrant's common shares contained in the Registration Statement
on Form 20-F filed with the Commission on August 22, 1997 including any amendments or reports filed
for the purpose of updating such description.
All documents subsequently filed by the registrant with the Commission pursuant to Sections
13(a), 13(c), 14 and 15(d) of the Exchange Act, prior to the filing of a post-effective amendment
to this Registration Statement that indicates that all securities offered hereby have been sold or
which deregisters all securities then remaining unsold, shall be deemed to be incorporated in this
Registration Statement by reference and to be a part hereof from the date of filing of such
documents, other than information in the documents that is not deemed to be filed with the
Commission.
Any statement contained herein or in a document incorporated or deemed to be incorporated by
reference herein, shall be deemed to be modified or superseded for purposes of this Registration
Statement to the extent that a statement contained in any subsequently filed document which is
incorporated by reference herein, modifies or supersedes the statement. Any statements so modified
or superseded shall not be deemed, except as so modified or superseded, to constitute a part of
this Registration Statement.
Item 8.     Exhibits.
The Exhibits to this Registration Statement are listed in the Index to Exhibits on the page
following the signature page to this Registration Statement.
SIGNATURES
Pursuant to the requirements of the Securities Act of 1933, the registrant certifies that it
has reasonable grounds to believe that it meets all of the requirements for filing on Form S-8 and
has duly caused this Registration Statement to be signed on its behalf by the undersigned,
thereunto duly authorized, in the City of Vancouver, Province of
British Columbia, on the 14th day
of September, 2007.
CARDIOME PHARMA CORP.
By:
/s/  ROBERT W. RIEDER
Robert W. Rieder, Chief Executive Officer
POWER OF ATTORNEY
KNOW ALL PERSONS BY THESE PRESENTS, that each person whose signature appears below constitutes
and appoints Robert W. Rieder and Douglas G. Janzen, jointly and severally, each in his own
capacity, his true and lawful attorneys-in-fact, with full power of substitution, for him and his
name, place and stead, in any and all capacities, to sign any and all amendments (including
post-effective amendments) to this registration statement, and to file the same, with all exhibits
thereto and other documents in connection therewith, with the Securities and Exchange Commission,
granting unto such said attorneys-in-fact and agents with full power and authority to do so and
perform each and every act and thing requisite and necessary to be done in and about the premises,
as fully to all intents and purposes as he might or could do in person, hereby ratifying and
confirming all that said attorneys-in-fact, or their substitute or substitutes, may lawfully do or
cause to be done by virtue hereof.
Pursuant to the requirements of the Securities Act of 1933, this Registration Statement has
been signed by the following persons in the capacities indicated on
September 14, 2007.
/s/  ROBERT W. RIEDER
Robert W. Rieder
Chief Executive Officer and Chairman of the Board of Directors
(Principal Executive Officer)
/s/  CURTIS SIKORSKY
Curtis Sikorsky
Chief Financial Officer (Principal Financial Officer and
Principal Accounting Officer)
/s/  RICHARD M. GLICKMAN
Richard M. Glickman
Director
/s/  JACKIE M. CLEGG
Jackie M. Clegg
Director
/s/  HAROLD H. SHLEVIN
Harold H. Shlevin
Director
/s/  PETER W. ROBERTS
Peter W. Roberts
Director
/s/  DOUGLAS G. JANZEN
Douglas G. Janzen
Director
/s/  WILLIAM L. HUNTER
William L. Hunter
Director
/s/  CHARLES
FISHER
Charles Fisher
Authorized Representative in the United States
INDEX TO EXHIBITS
Exhibit
Number
Description
5.1
Opinion of McCarthy Tétrault LLP
23.1
Consent of KPMG LLP, Chartered Accountants
23.2
Consent of Ernst & Young LLP, Chartered Accountants
23.3
Consent of McCarthy Tétrault LLP (included in Exhibit 5.1)
24.1
Power of Attorney (included as part of the signature page to this Registration Statement)
99.1
Cardiome Pharma Corp. Amended 2001 Incentive Stock Option Plan