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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>As filed with the Securities and Exchange
Commission on May 18, 2018</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: right"><B>Registration No.&nbsp;333-&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;
</B></P>


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<P STYLE="font: 14pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>UNITED STATES</B></P>

<P STYLE="font: 12pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><FONT STYLE="font-size: 14pt"><B>SECURITIES
AND EXCHANGE COMMISSION</B></FONT><BR>
<FONT STYLE="font-size: 10pt"><B>WASHINGTON, D.C. 20549 </B></FONT></P>


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<P STYLE="font: 12pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><FONT STYLE="font-size: 14pt"><B>FORM&nbsp;S-8</B></FONT><BR>
<FONT STYLE="font-size: 10pt"><B>REGISTRATION STATEMENT UNDER</B></FONT><BR>
<FONT STYLE="font-size: 10pt"><B>THE SECURITIES ACT OF 1933 </B></FONT></P>

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<P STYLE="font: 12pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><FONT STYLE="font-size: 14pt"><B>CHARLES
RIVER LABORATORIES</B></FONT><BR>
<FONT STYLE="font-size: 14pt"><B>INTERNATIONAL,&nbsp;INC.</B></FONT><BR>
<FONT STYLE="font-size: 10pt">(Exact Name of Registrant as Specified in Its Charter) </FONT></P>

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    <TD STYLE="width: 49%; text-align: center"><FONT STYLE="font-size: 10pt"><B>DELAWARE</B></FONT><BR>
<FONT STYLE="font-size: 10pt">(State or Other Jurisdiction</FONT><BR>
<FONT STYLE="font-size: 10pt">of Incorporation or Organization)</FONT></TD>
    <TD STYLE="width: 2%">&nbsp;</TD>
    <TD STYLE="width: 49%; text-align: center"><FONT STYLE="font-size: 10pt"><B>06-1397316</B></FONT><BR>
<FONT STYLE="font-size: 10pt">(I.R.S. Employer</FONT><BR>
<FONT STYLE="font-size: 10pt">Identification No.)</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: center">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD STYLE="text-align: center">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: center"><FONT STYLE="font-size: 10pt"><B>251 Ballardvale St., Wilmington, MA</B></FONT><BR>
<FONT STYLE="font-size: 10pt">(Address of Principal Executive Offices)</FONT></TD>
    <TD>&nbsp;</TD>
    <TD STYLE="text-align: center"><FONT STYLE="font-size: 10pt"><B>01887</B></FONT><BR>
<FONT STYLE="font-size: 10pt">(Zip Code)</FONT></TD></TR>
</TABLE>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>Charles River Laboratories International,
Inc. 2018 Incentive Plan</B><BR>
(Full Title of the Plan)</P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>David P. Johst</B><BR>
<B>Corporate Executive Vice President,</B><BR>
<B>General Counsel and</B><BR>
<B>Chief Administrative Officer</B><BR>
<B>Charles River Laboratories International,&nbsp;Inc.</B><BR>
<B>251 Ballardvale St.</B><BR>
<B>Wilmington, MA 01887</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">(Name and Address of Agent for Service)</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>(781)&nbsp;222-6000</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">(Telephone Number, Including Area Code,
of Agent for Service)</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; background-color: white">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; background-color: white"><FONT STYLE="background-color: white">Indicate
by check mark whether the registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, a smaller reporting
company or an emerging growth company. See the definitions of &ldquo;large accelerated filer,&rdquo; &ldquo;accelerated filer,&rdquo;
&ldquo;smaller reporting company&rdquo; and &ldquo;emerging growth company&rdquo; in Rule&nbsp;12b-2 of the Exchange Act. </FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; background-color: white">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
<TR STYLE="vertical-align: top; background-color: white">
    <TD STYLE="width: 67%"><FONT STYLE="font-size: 10pt">Large accelerated filer&nbsp;<FONT STYLE="font-family: Wingdings">x</FONT></FONT></TD>
    <TD STYLE="width: 33%"><FONT STYLE="font-size: 10pt">Accelerated filer&nbsp;<FONT STYLE="font-family: Wingdings">o</FONT></FONT></TD></TR>
<TR STYLE="vertical-align: top; background-color: white">
    <TD><FONT STYLE="font-size: 10pt">Non-accelerated filer&nbsp;<FONT STYLE="font-family: Wingdings">o</FONT> (Do not check if a smaller reporting company)</FONT></TD>
    <TD><FONT STYLE="font-size: 10pt">Smaller reporting company&nbsp;<FONT STYLE="font-family: Wingdings">o</FONT></FONT></TD></TR>
<TR STYLE="vertical-align: top; background-color: white">
    <TD STYLE="text-align: center">&nbsp;</TD>
    <TD><FONT STYLE="font-size: 10pt">Emerging growth company&nbsp;<FONT STYLE="font-family: Wingdings">o</FONT></FONT></TD></TR>
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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; background-color: white">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; background-color: white"><FONT STYLE="background-color: white">If
an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for
complying with any new or revised financial accounting standards provided pursuant to Section 7(a)(2)(B) of the Securities Act.
</FONT><FONT STYLE="font-family: Wingdings">o</FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; background-color: white">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>CALCULATION OF REGISTRATION FEE </B></P>

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<TR STYLE="vertical-align: top">
    <TD COLSPAN="9">

</TD></TR>
<TR STYLE="vertical-align: bottom">
    <TD STYLE="width: 34%; text-align: center; border-top: Black 1pt solid; border-bottom: Black 1pt solid"><FONT STYLE="font-size: 10pt"><B>Title of </B></FONT><BR>
<FONT STYLE="font-size: 10pt"><B>Securities to be Registered</B></FONT></TD>
    <TD STYLE="width: 1%; text-align: center; border-top: Black 1pt solid; border-bottom: Black 1pt solid">&nbsp;</TD>
    <TD STYLE="width: 14%; text-align: center; border-top: Black 1pt solid; border-bottom: Black 1pt solid"><FONT STYLE="font-size: 10pt"><B>Amount to</B></FONT><BR>
<FONT STYLE="font-size: 10pt"><B>be Registered(1)</B></FONT></TD>
    <TD STYLE="width: 1%; text-align: center; border-top: Black 1pt solid; border-bottom: Black 1pt solid">&nbsp;</TD>
    <TD STYLE="width: 17%; text-align: center; border-top: Black 1pt solid; border-bottom: Black 1pt solid"><FONT STYLE="font-size: 10pt"><B>Proposed Maximum</B></FONT><BR>
<FONT STYLE="font-size: 10pt"><B>Offering Price </B></FONT><BR>
<FONT STYLE="font-size: 10pt"><B>Per Share(2)</B></FONT></TD>
    <TD STYLE="width: 1%; text-align: center; border-top: Black 1pt solid; border-bottom: Black 1pt solid">&nbsp;</TD>
    <TD STYLE="width: 17%; text-align: center; border-top: Black 1pt solid; border-bottom: Black 1pt solid"><FONT STYLE="font-size: 10pt"><B>Proposed Maximum</B></FONT><BR>
<FONT STYLE="font-size: 10pt"><B>Aggregate</B></FONT><BR>
<FONT STYLE="font-size: 10pt"><B>Offering Price(2)</B></FONT></TD>
    <TD STYLE="width: 1%; text-align: center; border-top: Black 1pt solid; border-bottom: Black 1pt solid">&nbsp;</TD>
    <TD STYLE="width: 14%; text-align: center; border-top: Black 1pt solid; border-bottom: Black 1pt solid"><FONT STYLE="font-size: 10pt"><B>Amount of</B></FONT><BR>
<FONT STYLE="font-size: 10pt"><B>Registration Fee (2)(3)</B></FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD COLSPAN="9">
</TD></TR>
<TR STYLE="vertical-align: bottom">
    <TD STYLE="border-bottom: Black 1pt solid"><FONT STYLE="font-size: 10pt">Common Stock, par value $0.01 per share</FONT></TD>
    <TD STYLE="border-bottom: Black 1pt solid">&nbsp;</TD>
    <TD STYLE="text-align: center; border-bottom: Black 1pt solid"><FONT STYLE="font-size: 10pt">7,198,598 shares</FONT></TD>
    <TD STYLE="border-bottom: Black 1pt solid">&nbsp;</TD>
    <TD STYLE="text-align: center; border-bottom: Black 1pt solid"><FONT STYLE="font-size: 10pt">$103.81</FONT></TD>
    <TD STYLE="border-bottom: Black 1pt solid">&nbsp;</TD>
    <TD STYLE="text-align: center; border-bottom: Black 1pt solid"><FONT STYLE="font-size: 10pt">$747,286,458.38</FONT></TD>
    <TD STYLE="border-bottom: Black 1pt solid">&nbsp;</TD>
    <TD STYLE="text-align: center; border-bottom: Black 1pt solid"><FONT STYLE="font-size: 10pt">$93,037.17</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD COLSPAN="9">
</TD></TR>
</TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">(1)&nbsp;&nbsp;This Registration
Statement on Form S-8 (this &ldquo;<B>Registration Statement</B>&rdquo;) also relates to such indeterminate number of additional
shares of Charles River Laboratories International, Inc. Common Stock as may be required pursuant to the Registrant&rsquo;s 2018
Incentive Plan in the event of a reorganization, recapitalization, reclassification, stock dividend, stock split, reverse stock
split or other similar change in the Registrant's capital stock in accordance with Rule&nbsp;416 under the Securities Act of 1933,
as amended (the &ldquo;<B>Securities Act</B>&rdquo;).</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">(2)&nbsp;&nbsp;Estimated solely
for the purpose of computing the registration fee pursuant to Rule 457(c) and 457(h) under the Securities Act, based on the average
of the high ($104.65) and low ($102.96) prices of the Registrant&rsquo;s Common Stock, $0.01 par value per share, reported on the
New York Stock Exchange on May 16, 2018.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">(3)&nbsp;&nbsp;Rounded up to the nearest penny.&nbsp;</P>


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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>PART I </B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>INFORMATION REQUIRED IN THE SECTION 10(a)
PROSPECTUS </B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B>Item 1. PLAN INFORMATION.* </B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B>Item 2. REGISTRANT INFORMATION AND EMPLOYEE ANNUAL PLAN INFORMATION.*
</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&nbsp;&nbsp;*&nbsp;The
Section&nbsp;10(a) prospectus being delivered by Charles River Laboratories International,&nbsp;Inc. (the &ldquo;<B>Company</B>&rdquo;
or the &ldquo;<B>Registrant</B>&rdquo;) to participants in the Charles River Laboratories International,&nbsp;Inc. 2018 Incentive
Plan (the &ldquo;<B>Plan</B>&rdquo;), as required by Rule&nbsp;428 under the Securities Act, has been prepared in accordance with
the requirements of Form&nbsp;S-8 and relates to shares of common stock, par value $0.01 per share, of the Company (the &ldquo;<B>Common
Stock</B>&rdquo;) which have been reserved for issuance pursuant to the Plan. The information regarding the Plan required in the
Section&nbsp;10(a) prospectus is included in documents (including the documents incorporated by reference pursuant to Item 3 of
Part II hereof) being maintained and delivered by the Company to participants in the Plan as required by Rule&nbsp;428 under the
Securities Act. The Company shall provide to participants in the Plan a written statement advising them of the availability without
charge, upon written or oral request, of the documents incorporated by reference in Item 3 of Part II hereof, as is required by
Item 2 of Part&nbsp;I of Form&nbsp;S-8. The request shall be delivered to the Company, Attention: General Counsel at 251 Ballardvale
Street, Wilmington, MA, 01887, and the telephone number at that location is (781)&nbsp;222-6000.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><FONT STYLE="text-transform: uppercase"><B>Part&nbsp;II.
</B></FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><FONT STYLE="text-transform: uppercase"><B>Information
Required in the Registration Statement </B></FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B>Item 3. <FONT STYLE="text-transform: uppercase">Incorporation
of Documents by Reference</FONT></B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&nbsp;We hereby incorporate by reference
into this Registration Statement the following documents previously filed with the Securities and Exchange Commission (the &ldquo;<B>Commission</B>&rdquo;)
pursuant to the Securities Exchange Act of 1934, as amended (the &ldquo;<B>Exchange Act</B>&rdquo;):</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&nbsp;</P>

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<TD STYLE="width: 0.5in"></TD><TD STYLE="width: 0.5in">(a)</TD><TD>The Registrant&rsquo;s Annual Report on Form&nbsp;10-K for the fiscal year ended December&nbsp;30, 2017, as filed with the
Commission on February 13, 2018;</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.5in"></TD><TD STYLE="width: 0.5in">(b)</TD><TD>The Registrant&rsquo;s Quarterly Report on Form&nbsp;10-Q for the period ended March 31, 2018, as filed with the Commission
on May 10, 2018;</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.5in"></TD><TD STYLE="width: 0.5in">(c)</TD><TD>The Registrant&rsquo;s Current Reports on Form 8-K, as filed with the Commission on January 16, 2018, February 13, 2018 (two
Current Reports), March 26, 2018, April 3, 2018 and May 14, 2018;</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.5in"></TD><TD STYLE="width: 0.5in">(d)</TD><TD>The Registrant&rsquo;s Definitive Proxy Statement for the 2018 annual meeting of shareholders held on May 8, 2018, as filed
with the Commission on March 29, 2018; and</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.5in"></TD><TD STYLE="width: 0.5in">(e)</TD><TD>The description of the Registrant's Common Stock contained in the Registration Statement on Form&nbsp;8-A (File No. 001-15943)
filed with the Commission pursuant to Section&nbsp;12 of the Exchange Act, including any amendment or report filed for the purpose
of updating such description.</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">All other documents filed by the Registrant
with the Commission pursuant to Sections 13(a), 13(c), 14 and 15(d) of the Exchange Act subsequent to the date of this Registration
Statement and prior to the filing of a post-effective amendment to this Registration Statement which indicates that all securities
offered have been sold or which de-registers all securities then remaining unsold, shall be deemed to be incorporated by reference
in this Registration Statement and to be a part hereof from the date of filing such documents (such documents, and the documents
enumerated above, being hereinafter referred to collectively as the &ldquo;<B>Incorporated Documents</B>&rdquo;).</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&nbsp;</P>


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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">Any statement contained in an Incorporated
Document shall be deemed to be modified or superseded for purposes of this Registration Statement to the extent that a statement
contained herein or in any other subsequently filed Incorporated Document modifies or supersedes such statement. Any such statements
so modified or superseded shall not be deemed, except as so modified or superseded, to constitute a part of this Registration Statement.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B>Item 4. DESCRIPTION OF SECURITIES. </B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">Not applicable.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B>Item 5. <FONT STYLE="text-transform: uppercase">Interest
of Named Experts and Counsel</FONT></B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">David P. Johst, who has issued the opinion
of the Registrant's law department on the legality of the Common Stock offered hereby, is Corporate Executive Vice President, General
Counsel and Chief Administrative Officer of the Registrant. Mr.&nbsp;Johst owns shares of the Common Stock and holds employee stock
options to purchase the Common Stock, restricted stock, restricted stock units and performance share units. Mr. Johst is eligible
to participate in the Plan.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B>Item 6. INDEMNIFICATION OF DIRECTORS AND OFFICERS. </B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">Section 145 of the Delaware General Corporation
Law (&ldquo;<B>Delaware Law</B>&rdquo;) provides that a corporation may indemnify directors and officers as well as other employees
and individuals against expenses (including attorneys&rsquo; fees), judgments, fines and amounts paid in settlement actually and
reasonably incurred by such person in connection with any threatened, pending or completed actions, suits or proceedings in which
such person is made a party by reason of such person being or having been a director, officer, employee or agent of the Registrant.
The Delaware Law provides that Section 145 is not exclusive of other rights to which those seeking indemnification may be entitled
under any bylaw, agreement, vote of stockholders or disinterested directors or otherwise. The Registrant&rsquo;s second amended
and restated certificate of incorporation provides for indemnification by the Registrant of its directors, officers and employees
to the fullest extent permitted by the Delaware Law.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">Section 102(b)(7) of the Delaware Law permits
a corporation to provide in its certificate of incorporation that a director of the corporation shall not be personally liable
to the corporation or its stockholders for monetary damages for breach of fiduciary duty as a director, except for liability for
any breach of the director's duty of loyalty to the corporation or its stockholders, for acts or omissions not in good faith or
which involve intentional misconduct or a knowing violation of law, for unlawful payments of dividends or unlawful stock repurchases,
redemptions or other distributions, or for any transaction from which the director derived an improper personal benefit. The Registrant&rsquo;s
second amended and restated certificate of incorporation provides for such limitation of liability.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&nbsp;&nbsp;The Registrant maintains standard
policies of insurance under which coverage is provided to its directors and officers against loss rising from claims made by reason
of breach of duty, misstatement, error or omission committed in their capacity as directors or officers of the Registrant. Such
policies of insurance also provide coverage to the Registrant with respect to payments which may be made by the Registrant to such
officers and directors pursuant to the above indemnification provision or otherwise as a matter of law.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B>Item 7. EXEMPTION FROM REGISTRATION CLAIMED. </B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">Not Applicable.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&nbsp;</P>


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    <DIV STYLE="page-break-before: always; margin-top: 6pt; margin-bottom: 6pt"><P STYLE="margin: 0pt">&nbsp;</P></DIV>
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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B>Item 8. <FONT STYLE="text-transform: uppercase">Exhibits.</FONT></B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">The following exhibits are filed as part
of this Registration Statement:<BR>
<BR>
</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
<TR STYLE="vertical-align: top">
    <TD ROWSPAN="2" STYLE="border: Black 1pt solid; padding: 2pt">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><FONT STYLE="background-color: white"><B>Exhibit
        No.</B></FONT></P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P></TD>
    <TD ROWSPAN="2" STYLE="border-top: Black 1pt solid; border-right: Black 1pt solid; border-bottom: Black 1pt solid; padding: 2pt">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><FONT STYLE="background-color: white"><B>Description</B></FONT></P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P></TD>
    <TD ROWSPAN="2" STYLE="border-top: Black 1pt solid; border-right: Black 1pt solid; border-bottom: Black 1pt solid; padding: 2pt">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><FONT STYLE="background-color: white"><B>Filed
        with this Form S-8</B></FONT></P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P></TD>
    <TD COLSPAN="3" STYLE="border-top: Black 1pt solid; border-right: Black 1pt solid; border-bottom: Black 1pt solid; padding: 2pt; text-align: center"><FONT STYLE="font-size: 10pt; background-color: white"><B>Incorporated by Reference</B></FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="border-right: Black 1pt solid; border-bottom: Black 1pt solid; padding: 2pt; text-align: center"><FONT STYLE="font-size: 10pt; background-color: white"><B>Form</B></FONT></TD>
    <TD STYLE="border-right: Black 1pt solid; border-bottom: Black 1pt solid; padding: 2pt; text-align: center"><FONT STYLE="font-size: 10pt; background-color: white"><B>Filing Date</B></FONT></TD>
    <TD STYLE="border-right: Black 1pt solid; border-bottom: Black 1pt solid; padding: 2pt; text-align: center"><FONT STYLE="font-size: 10pt; background-color: white"><B>Exhibit No.</B></FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="width: 12%; border-right: Black 1pt solid; border-bottom: Black 1pt solid; border-left: Black 1pt solid; padding: 2pt"><A HREF="http://www.sec.gov/Archives/edgar/data/1100682/000091205700029480/ex-4_1.txt" STYLE="color: Blue; text-decoration: underline"><FONT STYLE="font-size: 10pt; background-color: white">4.1</FONT></A></TD>
    <TD STYLE="width: 40%; border-bottom: Black 1pt solid; padding: 2pt; border-right: Black 1pt solid"><A HREF="http://www.sec.gov/Archives/edgar/data/1100682/000091205700029480/ex-4_1.txt" STYLE="color: Blue; text-decoration: underline"><FONT STYLE="font-size: 10pt; background-color: white">Form of certificate representing shares of common stock, $0.01 par value per share</FONT></A></TD>
    <TD STYLE="width: 20%; border-bottom: Black 1pt solid; padding: 2pt; border-right: Black 1pt solid">&nbsp;</TD>
    <TD STYLE="width: 8%; border-bottom: Black 1pt solid; padding: 2pt; border-right: Black 1pt solid; text-align: center"><FONT STYLE="font-size: 10pt; background-color: white">S-1</FONT></TD>
    <TD STYLE="width: 10%; border-bottom: Black 1pt solid; padding: 2pt; border-right: Black 1pt solid; text-align: center"><FONT STYLE="font-size: 10pt; background-color: white">June 23, 2000</FONT></TD>
    <TD STYLE="width: 10%; border-bottom: Black 1pt solid; padding: 2pt; border-right: Black 1pt solid; text-align: center"><FONT STYLE="font-size: 10pt; background-color: white">4.1</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="border-right: Black 1pt solid; border-bottom: Black 1pt solid; border-left: Black 1pt solid; padding: 2pt"><A HREF="http://www.sec.gov/Archives/edgar/data/1100682/000091205700029480/ex-3_1.txt" STYLE="color: Blue; text-decoration: underline"><FONT STYLE="font-size: 10pt; background-color: white">4.2</FONT></A></TD>
    <TD STYLE="border-right: Black 1pt solid; border-bottom: Black 1pt solid; padding: 2pt"><A HREF="http://www.sec.gov/Archives/edgar/data/1100682/000091205700029480/ex-3_1.txt" STYLE="color: Blue; text-decoration: underline"><FONT STYLE="font-size: 10pt; background-color: white">Second Amended and Restated Certificate of Incorporation of Charles River Laboratories International, Inc.</FONT></A></TD>
    <TD STYLE="border-right: Black 1pt solid; border-bottom: Black 1pt solid; padding: 2pt">&nbsp;</TD>
    <TD STYLE="border-right: Black 1pt solid; border-bottom: Black 1pt solid; padding: 2pt; text-align: center"><FONT STYLE="font-size: 10pt; background-color: white">S-1</FONT></TD>
    <TD STYLE="border-right: Black 1pt solid; border-bottom: Black 1pt solid; padding: 2pt; text-align: center"><FONT STYLE="font-size: 10pt; background-color: white">June 23, 2000</FONT></TD>
    <TD STYLE="border-right: Black 1pt solid; border-bottom: Black 1pt solid; padding: 2pt; text-align: center"><FONT STYLE="font-size: 10pt; background-color: white">3.1</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="border-right: Black 1pt solid; border-bottom: Black 1pt solid; border-left: Black 1pt solid; padding: 2pt"><A HREF="http://www.sec.gov/Archives/edgar/data/1100682/000129993316002465/exhibit1.htm" STYLE="color: Blue; text-decoration: underline"><FONT STYLE="font-size: 10pt; background-color: white">4.3</FONT></A></TD>
    <TD STYLE="border-right: Black 1pt solid; border-bottom: Black 1pt solid; padding: 2pt"><A HREF="http://www.sec.gov/Archives/edgar/data/1100682/000129993316002465/exhibit1.htm" STYLE="color: Blue; text-decoration: underline"><FONT STYLE="font-size: 10pt; background-color: white">Fifth Amended and Restated By-Laws of Charles River Laboratories International, Inc.</FONT></A></TD>
    <TD STYLE="border-right: Black 1pt solid; border-bottom: Black 1pt solid; padding: 2pt; text-align: center">&nbsp;</TD>
    <TD STYLE="border-right: Black 1pt solid; border-bottom: Black 1pt solid; padding: 2pt; text-align: center"><FONT STYLE="font-size: 10pt; background-color: white">8-K</FONT></TD>
    <TD STYLE="border-right: Black 1pt solid; border-bottom: Black 1pt solid; padding: 2pt; text-align: center"><FONT STYLE="font-size: 10pt; background-color: white">May 16, 2016</FONT></TD>
    <TD STYLE="border-right: Black 1pt solid; border-bottom: Black 1pt solid; padding: 2pt; text-align: center"><FONT STYLE="font-size: 10pt; background-color: white">3.2</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="border-right: Black 1pt solid; border-bottom: Black 1pt solid; border-left: Black 1pt solid; padding: 2pt"><A HREF="dp91114_ex0501.htm" STYLE="color: Blue; text-decoration: underline"><FONT STYLE="font-size: 10pt; background-color: white">5.1</FONT></A></TD>
    <TD STYLE="border-right: Black 1pt solid; border-bottom: Black 1pt solid; padding: 2pt"><A HREF="dp91114_ex0501.htm" STYLE="color: Blue; text-decoration: underline"><FONT STYLE="font-size: 10pt; background-color: white">Opinion of David P. Johst, Esq., as to the legality of the securities being registered</FONT></A></TD>
    <TD STYLE="border-right: Black 1pt solid; border-bottom: Black 1pt solid; padding: 2pt; text-align: center"><FONT STYLE="font-size: 10pt; background-color: white">*</FONT></TD>
    <TD STYLE="border-right: Black 1pt solid; border-bottom: Black 1pt solid; padding: 2pt">&nbsp;</TD>
    <TD STYLE="border-right: Black 1pt solid; border-bottom: Black 1pt solid; padding: 2pt">&nbsp;</TD>
    <TD STYLE="border-right: Black 1pt solid; border-bottom: Black 1pt solid; padding: 2pt">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="border-right: Black 1pt solid; border-bottom: Black 1pt solid; border-left: Black 1pt solid; padding: 2pt"><A HREF="dp91114_ex0501.htm" STYLE="color: Blue; text-decoration: underline"><FONT STYLE="font-size: 10pt; background-color: white">23.1</FONT></A></TD>
    <TD STYLE="border-right: Black 1pt solid; border-bottom: Black 1pt solid; padding: 2pt"><A HREF="dp91114_ex0501.htm" STYLE="color: Blue; text-decoration: underline"><FONT STYLE="font-size: 10pt; background-color: white">Consent of David P. Johst, Esq. (included in Exhibit 5.1)</FONT></A></TD>
    <TD STYLE="border-right: Black 1pt solid; border-bottom: Black 1pt solid; padding: 2pt; text-align: center"><FONT STYLE="font-size: 10pt; background-color: white">*</FONT></TD>
    <TD STYLE="border-right: Black 1pt solid; border-bottom: Black 1pt solid; padding: 2pt">&nbsp;</TD>
    <TD STYLE="border-right: Black 1pt solid; border-bottom: Black 1pt solid; padding: 2pt">&nbsp;</TD>
    <TD STYLE="border-right: Black 1pt solid; border-bottom: Black 1pt solid; padding: 2pt">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="border-right: Black 1pt solid; border-bottom: Black 1pt solid; border-left: Black 1pt solid; padding: 2pt"><A HREF="dp91114_ex2302.htm" STYLE="color: Blue; text-decoration: underline"><FONT STYLE="font-size: 10pt; background-color: white">23.2</FONT></A></TD>
    <TD STYLE="border-right: Black 1pt solid; border-bottom: Black 1pt solid; padding: 2pt"><A HREF="dp91114_ex2302.htm" STYLE="color: Blue; text-decoration: underline"><FONT STYLE="font-size: 10pt; background-color: white">Consent of PricewaterhouseCoopers LLP</FONT></A></TD>
    <TD STYLE="border-right: Black 1pt solid; border-bottom: Black 1pt solid; padding: 2pt; text-align: center"><FONT STYLE="font-size: 10pt; background-color: white">*</FONT></TD>
    <TD STYLE="border-right: Black 1pt solid; border-bottom: Black 1pt solid; padding: 2pt">&nbsp;</TD>
    <TD STYLE="border-right: Black 1pt solid; border-bottom: Black 1pt solid; padding: 2pt">&nbsp;</TD>
    <TD STYLE="border-right: Black 1pt solid; border-bottom: Black 1pt solid; padding: 2pt">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="border-right: Black 1pt solid; border-bottom: Black 1pt solid; border-left: Black 1pt solid; padding: 2pt"><A HREF="#poa" STYLE="color: Blue; text-decoration: underline"><FONT STYLE="font-size: 10pt; background-color: white">24.1</FONT></A></TD>
    <TD STYLE="border-right: Black 1pt solid; border-bottom: Black 1pt solid; padding: 2pt"><A HREF="#poa" STYLE="color: Blue; text-decoration: underline"><FONT STYLE="font-size: 10pt; background-color: white">Power of Attorney (included on the signature page of this Registration Statement)</FONT></A></TD>
    <TD STYLE="border-right: Black 1pt solid; border-bottom: Black 1pt solid; padding: 2pt; text-align: center"><FONT STYLE="font-size: 10pt; background-color: white">*</FONT></TD>
    <TD STYLE="border-right: Black 1pt solid; border-bottom: Black 1pt solid; padding: 2pt">&nbsp;</TD>
    <TD STYLE="border-right: Black 1pt solid; border-bottom: Black 1pt solid; padding: 2pt">&nbsp;</TD>
    <TD STYLE="border-right: Black 1pt solid; border-bottom: Black 1pt solid; padding: 2pt">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="border-right: Black 1pt solid; border-bottom: Black 1pt solid; border-left: Black 1pt solid; padding: 2pt"><A HREF="http://www.sec.gov/Archives/edgar/data/1100682/000110068218000008/crl3312018ex102.htm" STYLE="color: Blue; text-decoration: underline"><FONT STYLE="font-size: 10pt; background-color: white">99.1</FONT></A></TD>
    <TD STYLE="border-right: Black 1pt solid; border-bottom: Black 1pt solid; padding: 2pt"><A HREF="http://www.sec.gov/Archives/edgar/data/1100682/000110068218000008/crl3312018ex102.htm" STYLE="color: Blue; text-decoration: underline"><FONT STYLE="font-size: 10pt; background-color: white">Charles River Laboratories International, Inc. 2018 Incentive Plan</FONT></A></TD>
    <TD STYLE="border-right: Black 1pt solid; border-bottom: Black 1pt solid; padding: 2pt; text-align: center">&nbsp;</TD>
    <TD STYLE="border-right: Black 1pt solid; border-bottom: Black 1pt solid; padding: 2pt; text-align: center"><FONT STYLE="font-size: 10pt; background-color: white">10-Q</FONT></TD>
    <TD STYLE="border-right: Black 1pt solid; border-bottom: Black 1pt solid; padding: 2pt; text-align: center"><FONT STYLE="font-size: 10pt; background-color: white">May 10, 2018</FONT></TD>
    <TD STYLE="border-right: Black 1pt solid; border-bottom: Black 1pt solid; padding: 2pt; text-align: center"><FONT STYLE="font-size: 10pt; background-color: white">10.2</FONT></TD></TR>
</TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B>Item 9. UNDERTAKINGS. </B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">(a)&nbsp;&nbsp;The
Registrant hereby undertakes:</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 1in">(1)&nbsp;&nbsp;to
file, during any period in which offers or sales are being made, a post-effective amendment to this Registration Statement:</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 1in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in; text-indent: 1in">(i)&nbsp;&nbsp;To
include any prospectus required by Section&nbsp;10(a)(3) of the Securities Act;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in; text-indent: 1in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in; text-indent: 1in">(ii) &nbsp;&nbsp;To
reflect in the prospectus any facts or events arising after the effective date of the Registration Statement (or the most recent
post-effective amendment thereof) which, individually or in the aggregate, represent a fundamental change in the information set
forth in the Registration Statement. Notwithstanding the foregoing, any increase or decrease in volume of securities offered (if
the total dollar value of securities offered would not exceed that which was registered) and any deviation from the low or high
end of the estimated maximum offering range may be reflected in the form of prospectus filed with the Commission pursuant to Rule&nbsp;424(b)
if, in the aggregate, the changes in volume and price represent no more than a 20&nbsp;percent change in the maximum aggregate
offering price set forth in the &ldquo;Calculation of Registration Fee&rdquo; table in the effective Registration Statement;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in; text-indent: 1in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in; text-indent: 1in">(iii) To include any material information
with respect to the plan of distribution not previously disclosed in the Registration Statement or any material change to such
information in the Registration Statement;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in; text-indent: 1in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 1.5in">PROVIDED, HOWEVER, that paragraphs (a)(1)(i)&nbsp;and
(a)(1)(ii)&nbsp;do not apply if the information required to be included in a post-effective amendment by those paragraphs is contained
in periodic reports filed with or furnished to the Commission by the Registrant pursuant to Section&nbsp;13 or 15(d) of the Exchange
Act that are incorporated by reference in the Registration Statement.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 1.5in">&nbsp;</P>


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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 1in">(2)&nbsp;&nbsp;That,
for the purpose of determining any liability under the Securities Act, each such post-effective amendment shall be deemed to be
a new registration statement relating to the securities offered therein, and the offering of such securities at that time shall
be deemed to be the initial <I>bona fide</I> offering thereof.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 1in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 1in">(3) &nbsp;&nbsp;To
remove from registration by means of a post-effective amendment any of the securities being registered which remain unsold at the
termination of the offering.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 1in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">(b)&nbsp;&nbsp;The
Registrant hereby undertakes that, for purposes of determining any liability under the Securities Act, each filing of the Registrant's
annual report pursuant to Section&nbsp;13(a) or 15(d) of the Exchange Act (and, where applicable, each filing of an employee benefit
plan's annual report pursuant to Section&nbsp;15(d) of the Exchange Act) that is incorporated by reference in the Registration
Statement shall be deemed to be a new registration statement relating to the securities offered therein, and the offering of such
securities at that time shall be deemed to be the initial <I>bona fide</I> offering thereof.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">(c)&nbsp;&nbsp;Insofar
as indemnification for liabilities arising under the Securities Act may be permitted to directors, officers and controlling persons
of the Registrant pursuant to the foregoing provisions, or otherwise, the Registrant has been advised that in the opinion of the
Commission such indemnification is against public policy as expressed in the Act and is, therefore, unenforceable. In the event
that a claim for indemnification against such liabilities (other than the payment by the Registrant of expenses incurred or paid
by a director, officer or controlling person of the Registrant in the successful defense of any action, suit or proceeding) is
asserted by such director, officer or controlling person in connection with the securities being registered, the Registrant will,
unless in the opinion of its counsel the matter has been settled by controlling precedent, submit to a court of appropriate jurisdiction
the question whether such indemnification by it is against public policy as expressed in the Securities Act and will be governed
by the final adjudication of such issue.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&nbsp;</P>


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    <DIV STYLE="page-break-before: always; margin-top: 6pt; margin-bottom: 6pt"><P STYLE="margin: 0pt">&nbsp;</P></DIV>
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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>SIGNATURES </B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;&nbsp;&nbsp;Pursuant
to the requirements of the Securities Act, the Registrant certifies that it has reasonable grounds to believe that it meets all
of the requirements for filing on Form&nbsp;S-8 and has duly caused this Registration Statement to be signed on its behalf by the
undersigned, thereunto duly authorized, in the city of Boston, Commonwealth of Massachusetts on May 18, 2018.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%">
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD COLSPAN="2"><FONT STYLE="font-size: 10pt">CHARLES RIVER LABORATORIES INTERNATIONAL,&nbsp;INC.</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD COLSPAN="2">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="width: 39%">&nbsp;</TD>
    <TD STYLE="width: 2%">&nbsp;</TD>
    <TD STYLE="width: 3%"><BR>
<FONT STYLE="font-size: 10pt">By:</FONT></TD>
    <TD STYLE="width: 56%">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center; border-bottom: Black 1pt solid"><BR>
/s/&nbsp;&nbsp;JAMES C. FOSTER</P>



        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center">James C.
Foster<BR>
<I>Chairman and Chief Executive Officer</I></P></TD></TR>
</TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; text-indent: 0.25in">&nbsp;&nbsp;&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; text-indent: 0.25in">&nbsp;</P>


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    <DIV STYLE="page-break-before: always; margin-top: 6pt; margin-bottom: 6pt"><P STYLE="margin: 0pt">&nbsp;</P></DIV>
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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B><A NAME="poa"></A>POWER OF ATTORNEY AND SIGNATURES </B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;&nbsp;&nbsp;We,
the undersigned officers and directors of Charles River Laboratories International,&nbsp;Inc., hereby severally constitute and
appoint James C. Foster, David P. Johst and David R. Smith and each of them singly, as true and lawful attorneys-in-fact, with
full power of substitution, to sign for us in our names in the capacities indicated below, all additional amendments (including
post-effective amendments) to this Registration Statement, and generally to do all things in our names and on our behalf in such
capacities to enable Charles River Laboratories International,&nbsp;Inc. to comply with the provisions of the Securities Act, and
all applicable requirements of the Commission.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">Pursuant to the requirements of the Securities
Act, this Registration Statement has been signed by the following persons in the capacities and on the dates indicated.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
<TR STYLE="vertical-align: bottom">
    <TD COLSPAN="2" STYLE="text-align: center"><FONT STYLE="font-size: 10pt">Signatures</FONT></TD>
    <TD STYLE="text-align: center"><FONT STYLE="font-size: 10pt">Title</FONT></TD>
    <TD STYLE="text-align: center"><FONT STYLE="font-size: 10pt">Date</FONT></TD></TR>
<TR STYLE="vertical-align: bottom">
    <TD STYLE="width: 5%"><FONT STYLE="font-size: 10pt">By:</FONT></TD>
    <TD STYLE="width: 29%; border-bottom: Black 1pt solid; text-align: center"><FONT STYLE="font-size: 10pt">/s/ JAMES C. FOSTER</FONT></TD>
    <TD STYLE="width: 44%"><FONT STYLE="font-size: 10pt"><I>Chairman and Chief Executive Officer</I></FONT></TD>
    <TD STYLE="width: 22%; text-align: center"><FONT STYLE="font-size: 10pt">May 18, 2018</FONT></TD></TR>
<TR STYLE="vertical-align: bottom">
    <TD>&nbsp;</TD>
    <TD STYLE="text-align: center"><FONT STYLE="font-size: 10pt">James C. Foster</FONT></TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom">
    <TD><FONT STYLE="font-size: 10pt">By:</FONT></TD>
    <TD STYLE="border-bottom: Black 1pt solid; text-align: center"><FONT STYLE="font-size: 10pt">/s/ DAVID R. SMITH</FONT></TD>
    <TD><FONT STYLE="font-size: 10pt"><I>Corporate Executive Vice President and</I></FONT></TD>
    <TD STYLE="text-align: center"><FONT STYLE="font-size: 10pt">May 18, 2018</FONT></TD></TR>
<TR STYLE="vertical-align: bottom">
    <TD>&nbsp;</TD>
    <TD STYLE="text-align: center"><FONT STYLE="font-size: 10pt">David R. Smith</FONT></TD>
    <TD><FONT STYLE="font-size: 10pt"><I>Chief Financial Officer</I></FONT></TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom">
    <TD><FONT STYLE="font-size: 10pt">By:</FONT></TD>
    <TD STYLE="border-bottom: Black 1pt solid; text-align: center"><FONT STYLE="font-size: 10pt">/s/&nbsp;MICHAEL G. KNELL</FONT></TD>
    <TD><FONT STYLE="font-size: 10pt"><I>Corporate Senior Vice President and</I></FONT></TD>
    <TD STYLE="text-align: center"><FONT STYLE="font-size: 10pt">May 18, 2018</FONT></TD></TR>
<TR STYLE="vertical-align: bottom">
    <TD>&nbsp;</TD>
    <TD STYLE="text-align: center"><FONT STYLE="font-size: 10pt">Michael G. Knell</FONT></TD>
    <TD><FONT STYLE="font-size: 10pt"><I>Chief Accounting Officer</I></FONT></TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom">
    <TD><FONT STYLE="font-size: 10pt">By:</FONT></TD>
    <TD STYLE="border-bottom: Black 1pt solid; text-align: center"><FONT STYLE="font-size: 10pt">/s/&nbsp;ROBERT J. BERTOLINI</FONT></TD>
    <TD><FONT STYLE="font-size: 10pt"><I>Director</I></FONT></TD>
    <TD STYLE="text-align: center"><FONT STYLE="font-size: 10pt">May 18, 2018</FONT></TD></TR>
<TR STYLE="vertical-align: bottom">
    <TD>&nbsp;</TD>
    <TD STYLE="text-align: center"><FONT STYLE="font-size: 10pt">Robert J. Bertolini</FONT></TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom">
    <TD><FONT STYLE="font-size: 10pt">By:</FONT></TD>
    <TD STYLE="border-bottom: Black 1pt solid; text-align: center"><FONT STYLE="font-size: 10pt">/s/&nbsp;STEPHEN D. CHUBB</FONT></TD>
    <TD><FONT STYLE="font-size: 10pt"><I>Director</I></FONT></TD>
    <TD STYLE="text-align: center"><FONT STYLE="font-size: 10pt">May 18, 2018</FONT></TD></TR>
<TR STYLE="vertical-align: bottom">
    <TD>&nbsp;</TD>
    <TD STYLE="text-align: center"><FONT STYLE="font-size: 10pt">Stephen D. Chubb</FONT></TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom">
    <TD><FONT STYLE="font-size: 10pt">By:</FONT></TD>
    <TD STYLE="border-bottom: Black 1pt solid; text-align: center"><FONT STYLE="font-size: 10pt">/s/&nbsp;DEBORAH T. KOCHEVAR</FONT></TD>
    <TD><FONT STYLE="font-size: 10pt"><I>Director</I></FONT></TD>
    <TD STYLE="text-align: center"><FONT STYLE="font-size: 10pt">May 18, 2018</FONT></TD></TR>
<TR STYLE="vertical-align: bottom">
    <TD>&nbsp;</TD>
    <TD STYLE="text-align: center"><FONT STYLE="font-size: 10pt">Deborah T. Kochevar</FONT></TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom">
    <TD><FONT STYLE="font-size: 10pt">By:</FONT></TD>
    <TD STYLE="border-bottom: Black 1pt solid; text-align: center"><FONT STYLE="font-size: 10pt">/s/&nbsp;MARTIN W. MACKAY</FONT></TD>
    <TD><FONT STYLE="font-size: 10pt"><I>Director</I></FONT></TD>
    <TD STYLE="text-align: center"><FONT STYLE="font-size: 10pt">May 18, 2018</FONT></TD></TR>
<TR STYLE="vertical-align: bottom">
    <TD>&nbsp;</TD>
    <TD STYLE="text-align: center"><FONT STYLE="font-size: 10pt">Martin W. Mackay</FONT></TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom">
    <TD><FONT STYLE="font-size: 10pt">By:</FONT></TD>
    <TD STYLE="border-bottom: Black 1pt solid; text-align: center"><FONT STYLE="font-size: 10pt">/s/&nbsp;JEAN-PAUL MANGEOLLE</FONT></TD>
    <TD><FONT STYLE="font-size: 10pt"><I>Director</I></FONT></TD>
    <TD STYLE="text-align: center"><FONT STYLE="font-size: 10pt">May 18, 2018</FONT></TD></TR>
<TR STYLE="vertical-align: bottom">
    <TD>&nbsp;</TD>
    <TD STYLE="text-align: center"><FONT STYLE="font-size: 10pt">Jean-Paul Mangeolle</FONT></TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom">
    <TD><FONT STYLE="font-size: 10pt">By:</FONT></TD>
    <TD STYLE="border-bottom: Black 1pt solid; text-align: center"><FONT STYLE="font-size: 10pt">/s/&nbsp;GEORGE E. MASSARO</FONT></TD>
    <TD><FONT STYLE="font-size: 10pt"><I>Director</I></FONT></TD>
    <TD STYLE="text-align: center"><FONT STYLE="font-size: 10pt">May 18, 2018</FONT></TD></TR>
<TR STYLE="vertical-align: bottom">
    <TD>&nbsp;</TD>
    <TD STYLE="text-align: center"><FONT STYLE="font-size: 10pt">George E. Massaro</FONT></TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom">
    <TD><FONT STYLE="font-size: 10pt">By:</FONT></TD>
    <TD STYLE="border-bottom: Black 1pt solid; text-align: center"><FONT STYLE="font-size: 10pt">/s/&nbsp;GEORGE M. MILNE, JR.</FONT></TD>
    <TD><FONT STYLE="font-size: 10pt"><I>Director</I></FONT></TD>
    <TD STYLE="text-align: center"><FONT STYLE="font-size: 10pt">May 18, 2018</FONT></TD></TR>
<TR STYLE="vertical-align: bottom">
    <TD>&nbsp;</TD>
    <TD STYLE="text-align: center"><FONT STYLE="font-size: 10pt">George M. Milne, Jr.</FONT></TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom">
    <TD><FONT STYLE="font-size: 10pt">By:</FONT></TD>
    <TD STYLE="border-bottom: Black 1pt solid; text-align: center"><FONT STYLE="font-size: 10pt">/s/&nbsp;C. RICHARD REESE</FONT></TD>
    <TD><FONT STYLE="font-size: 10pt"><I>Director</I></FONT></TD>
    <TD STYLE="text-align: center"><FONT STYLE="font-size: 10pt">May 18, 2018</FONT></TD></TR>
<TR STYLE="vertical-align: bottom">
    <TD>&nbsp;</TD>
    <TD STYLE="text-align: center"><FONT STYLE="font-size: 10pt">C. Richard Reese</FONT></TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom">
    <TD><FONT STYLE="font-size: 10pt">By:</FONT></TD>
    <TD STYLE="border-bottom: Black 1pt solid; text-align: center">&nbsp;&nbsp;&nbsp;</TD>
    <TD><FONT STYLE="font-size: 10pt"><I>Director</I></FONT></TD>
    <TD STYLE="text-align: center">&nbsp;&nbsp;&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom">
    <TD>&nbsp;</TD>
    <TD STYLE="text-align: center"><FONT STYLE="font-size: 10pt">Craig B. Thompson</FONT></TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom">
    <TD><FONT STYLE="font-size: 10pt">By:</FONT></TD>
    <TD STYLE="border-bottom: Black 1pt solid; text-align: center"><FONT STYLE="font-size: 10pt">/s/&nbsp;RICHARD F. WALLMAN</FONT></TD>
    <TD><FONT STYLE="font-size: 10pt"><I>Director</I></FONT></TD>
    <TD STYLE="text-align: center"><FONT STYLE="font-size: 10pt">May 18, 2018</FONT></TD></TR>
<TR STYLE="vertical-align: bottom">
    <TD>&nbsp;</TD>
    <TD STYLE="text-align: center"><FONT STYLE="font-size: 10pt">Richard F. Wallman</FONT></TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
</TABLE>

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    <DIV STYLE="page-break-before: always; margin-top: 6pt; margin-bottom: 6pt"><P STYLE="margin: 0pt">&nbsp;</P></DIV>
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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>Exhibit Index</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
<TR STYLE="vertical-align: top">
    <TD ROWSPAN="2" STYLE="border: Black 1pt solid; padding: 2pt">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><FONT STYLE="background-color: white"><B>Exhibit
        No.</B></FONT></P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P></TD>
    <TD ROWSPAN="2" STYLE="border-top: Black 1pt solid; border-right: Black 1pt solid; border-bottom: Black 1pt solid; padding: 2pt">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><FONT STYLE="background-color: white"><B>Description</B></FONT></P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P></TD>
    <TD ROWSPAN="2" STYLE="border-top: Black 1pt solid; border-right: Black 1pt solid; border-bottom: Black 1pt solid; padding: 2pt">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><FONT STYLE="background-color: white"><B>Filed
        with this Form S-8</B></FONT></P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P></TD>
    <TD COLSPAN="3" STYLE="border-top: Black 1pt solid; border-right: Black 1pt solid; border-bottom: Black 1pt solid; padding: 2pt; text-align: center"><FONT STYLE="font-size: 10pt; background-color: white"><B>Incorporated by Reference</B></FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="border-right: Black 1pt solid; border-bottom: Black 1pt solid; padding: 2pt; text-align: center"><FONT STYLE="font-size: 10pt; background-color: white"><B>Form</B></FONT></TD>
    <TD STYLE="border-right: Black 1pt solid; border-bottom: Black 1pt solid; padding: 2pt; text-align: center"><FONT STYLE="font-size: 10pt; background-color: white"><B>Filing Date</B></FONT></TD>
    <TD STYLE="border-right: Black 1pt solid; border-bottom: Black 1pt solid; padding: 2pt; text-align: center"><FONT STYLE="font-size: 10pt; background-color: white"><B>Exhibit No.</B></FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="width: 12%; border-right: Black 1pt solid; border-bottom: Black 1pt solid; border-left: Black 1pt solid; padding: 2pt"><FONT STYLE="font-size: 10pt; background-color: white">4.1</FONT></TD>
    <TD STYLE="width: 40%; border-bottom: Black 1pt solid; padding: 2pt; border-right: Black 1pt solid"><FONT STYLE="font-size: 10pt; background-color: white">Form of certificate representing shares of common stock, $0.01 par value per share</FONT></TD>
    <TD STYLE="width: 20%; border-bottom: Black 1pt solid; padding: 2pt; border-right: Black 1pt solid">&nbsp;</TD>
    <TD STYLE="width: 8%; border-bottom: Black 1pt solid; padding: 2pt; border-right: Black 1pt solid; text-align: center"><FONT STYLE="font-size: 10pt; background-color: white">S-1</FONT></TD>
    <TD STYLE="width: 10%; border-bottom: Black 1pt solid; padding: 2pt; border-right: Black 1pt solid; text-align: center"><FONT STYLE="font-size: 10pt; background-color: white">June 23, 2000</FONT></TD>
    <TD STYLE="width: 10%; border-bottom: Black 1pt solid; padding: 2pt; border-right: Black 1pt solid; text-align: center"><FONT STYLE="font-size: 10pt; background-color: white">4.1</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="border-right: Black 1pt solid; border-bottom: Black 1pt solid; border-left: Black 1pt solid; padding: 2pt"><FONT STYLE="font-size: 10pt; background-color: white">4.2</FONT></TD>
    <TD STYLE="border-right: Black 1pt solid; border-bottom: Black 1pt solid; padding: 2pt"><FONT STYLE="font-size: 10pt; background-color: white">Second Amended and Restated Certificate of Incorporation of Charles River Laboratories International, Inc.</FONT></TD>
    <TD STYLE="border-right: Black 1pt solid; border-bottom: Black 1pt solid; padding: 2pt">&nbsp;</TD>
    <TD STYLE="border-right: Black 1pt solid; border-bottom: Black 1pt solid; padding: 2pt; text-align: center"><FONT STYLE="font-size: 10pt; background-color: white">S-1</FONT></TD>
    <TD STYLE="border-right: Black 1pt solid; border-bottom: Black 1pt solid; padding: 2pt; text-align: center"><FONT STYLE="font-size: 10pt; background-color: white">June 23, 2000</FONT></TD>
    <TD STYLE="border-right: Black 1pt solid; border-bottom: Black 1pt solid; padding: 2pt; text-align: center"><FONT STYLE="font-size: 10pt; background-color: white">3.1</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="border-right: Black 1pt solid; border-bottom: Black 1pt solid; border-left: Black 1pt solid; padding: 2pt"><FONT STYLE="font-size: 10pt; background-color: white">4.3</FONT></TD>
    <TD STYLE="border-right: Black 1pt solid; border-bottom: Black 1pt solid; padding: 2pt"><FONT STYLE="font-size: 10pt; background-color: white">Fifth Amended and Restated By-Laws of Charles River Laboratories International, Inc.</FONT></TD>
    <TD STYLE="border-right: Black 1pt solid; border-bottom: Black 1pt solid; padding: 2pt; text-align: center">&nbsp;</TD>
    <TD STYLE="border-right: Black 1pt solid; border-bottom: Black 1pt solid; padding: 2pt; text-align: center"><FONT STYLE="font-size: 10pt; background-color: white">8-K</FONT></TD>
    <TD STYLE="border-right: Black 1pt solid; border-bottom: Black 1pt solid; padding: 2pt; text-align: center"><FONT STYLE="font-size: 10pt; background-color: white">May 16, 2016</FONT></TD>
    <TD STYLE="border-right: Black 1pt solid; border-bottom: Black 1pt solid; padding: 2pt; text-align: center"><FONT STYLE="font-size: 10pt; background-color: white">3.2</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="border-right: Black 1pt solid; border-bottom: Black 1pt solid; border-left: Black 1pt solid; padding: 2pt"><FONT STYLE="font-size: 10pt; background-color: white">5.1</FONT></TD>
    <TD STYLE="border-right: Black 1pt solid; border-bottom: Black 1pt solid; padding: 2pt"><FONT STYLE="font-size: 10pt; background-color: white">Opinion of David P. Johst, Esq., as to the legality of the securities being registered</FONT></TD>
    <TD STYLE="border-right: Black 1pt solid; border-bottom: Black 1pt solid; padding: 2pt; text-align: center"><FONT STYLE="font-size: 10pt; background-color: white">*</FONT></TD>
    <TD STYLE="border-right: Black 1pt solid; border-bottom: Black 1pt solid; padding: 2pt">&nbsp;</TD>
    <TD STYLE="border-right: Black 1pt solid; border-bottom: Black 1pt solid; padding: 2pt">&nbsp;</TD>
    <TD STYLE="border-right: Black 1pt solid; border-bottom: Black 1pt solid; padding: 2pt">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="border-right: Black 1pt solid; border-bottom: Black 1pt solid; border-left: Black 1pt solid; padding: 2pt"><FONT STYLE="font-size: 10pt; background-color: white">23.1</FONT></TD>
    <TD STYLE="border-right: Black 1pt solid; border-bottom: Black 1pt solid; padding: 2pt"><FONT STYLE="font-size: 10pt; background-color: white">Consent of David P. Johst, Esq. (included in Exhibit 5.1)</FONT></TD>
    <TD STYLE="border-right: Black 1pt solid; border-bottom: Black 1pt solid; padding: 2pt; text-align: center"><FONT STYLE="font-size: 10pt; background-color: white">*</FONT></TD>
    <TD STYLE="border-right: Black 1pt solid; border-bottom: Black 1pt solid; padding: 2pt">&nbsp;</TD>
    <TD STYLE="border-right: Black 1pt solid; border-bottom: Black 1pt solid; padding: 2pt">&nbsp;</TD>
    <TD STYLE="border-right: Black 1pt solid; border-bottom: Black 1pt solid; padding: 2pt">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="border-right: Black 1pt solid; border-bottom: Black 1pt solid; border-left: Black 1pt solid; padding: 2pt"><FONT STYLE="font-size: 10pt; background-color: white">23.2</FONT></TD>
    <TD STYLE="border-right: Black 1pt solid; border-bottom: Black 1pt solid; padding: 2pt"><FONT STYLE="font-size: 10pt; background-color: white">Consent of PricewaterhouseCoopers LLP</FONT></TD>
    <TD STYLE="border-right: Black 1pt solid; border-bottom: Black 1pt solid; padding: 2pt; text-align: center"><FONT STYLE="font-size: 10pt; background-color: white">*</FONT></TD>
    <TD STYLE="border-right: Black 1pt solid; border-bottom: Black 1pt solid; padding: 2pt">&nbsp;</TD>
    <TD STYLE="border-right: Black 1pt solid; border-bottom: Black 1pt solid; padding: 2pt">&nbsp;</TD>
    <TD STYLE="border-right: Black 1pt solid; border-bottom: Black 1pt solid; padding: 2pt">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="border-right: Black 1pt solid; border-bottom: Black 1pt solid; border-left: Black 1pt solid; padding: 2pt"><FONT STYLE="font-size: 10pt; background-color: white">24.1</FONT></TD>
    <TD STYLE="border-right: Black 1pt solid; border-bottom: Black 1pt solid; padding: 2pt"><FONT STYLE="font-size: 10pt; background-color: white">Power of Attorney (included on the signature page of this Registration Statement)</FONT></TD>
    <TD STYLE="border-right: Black 1pt solid; border-bottom: Black 1pt solid; padding: 2pt; text-align: center"><FONT STYLE="font-size: 10pt; background-color: white">*</FONT></TD>
    <TD STYLE="border-right: Black 1pt solid; border-bottom: Black 1pt solid; padding: 2pt">&nbsp;</TD>
    <TD STYLE="border-right: Black 1pt solid; border-bottom: Black 1pt solid; padding: 2pt">&nbsp;</TD>
    <TD STYLE="border-right: Black 1pt solid; border-bottom: Black 1pt solid; padding: 2pt">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="border-right: Black 1pt solid; border-bottom: Black 1pt solid; border-left: Black 1pt solid; padding: 2pt"><FONT STYLE="font-size: 10pt; background-color: white">99.1</FONT></TD>
    <TD STYLE="border-right: Black 1pt solid; border-bottom: Black 1pt solid; padding: 2pt"><FONT STYLE="font-size: 10pt; background-color: white">Charles River Laboratories International, Inc. 2018 Incentive Plan</FONT></TD>
    <TD STYLE="border-right: Black 1pt solid; border-bottom: Black 1pt solid; padding: 2pt; text-align: center">&nbsp;</TD>
    <TD STYLE="border-right: Black 1pt solid; border-bottom: Black 1pt solid; padding: 2pt; text-align: center"><FONT STYLE="font-size: 10pt; background-color: white">10-Q</FONT></TD>
    <TD STYLE="border-right: Black 1pt solid; border-bottom: Black 1pt solid; padding: 2pt; text-align: center"><FONT STYLE="font-size: 10pt; background-color: white">May 10, 2018</FONT></TD>
    <TD STYLE="border-right: Black 1pt solid; border-bottom: Black 1pt solid; padding: 2pt; text-align: center"><FONT STYLE="font-size: 10pt; background-color: white">10.2</FONT></TD></TR>
</TABLE>

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[{"type": "S-8", "sequence": "1", "filename": "dp91114_s8.htm", "description": "FORM S-8", "secsgml_size_bytes": 72306}]
{"company-data": {"conformed-name": "CHARLES RIVER LABORATORIES INTERNATIONAL INC", "cik": "0001100682", "assigned-sic": "8731", "irs-number": "061397316", "fiscal-year-end": "1231"}, "filing-values": {"form-type": "S-8", "act": "33", "file-number": "333-225046", "film-number": "18847340"}, "business-address": {"street1": "251 BALLARDVALE ST", "city": "WILMINGTON", "state": "MA", "zip": "01887", "phone": "781-222-6000"}, "mail-address": {"street1": "251 BALLARDVALE ST", "city": "WILMINGTON", "state": "MA", "zip": "01887"}, "former-company": {"former-conformed-name": "CHARLES RIVER LABORATORIES HOLDINGS INC", "date-changed": "19991208"}}
As filed with the Securities and Exchange
Commission on May 18, 2018
Registration No. 333-
UNITED STATES
SECURITIES
AND EXCHANGE COMMISSION
WASHINGTON, D.C. 20549
FORM S-8
REGISTRATION STATEMENT UNDER
THE SECURITIES ACT OF 1933
CHARLES
RIVER LABORATORIES
INTERNATIONAL, INC.
(Exact Name of Registrant as Specified in Its Charter)
DELAWARE
(State or Other Jurisdiction
of Incorporation or Organization)
06-1397316
(I.R.S. Employer
Identification No.)
251 Ballardvale St., Wilmington, MA
(Address of Principal Executive Offices)
01887
(Zip Code)
Charles River Laboratories International,
Inc. 2018 Incentive Plan
(Full Title of the Plan)
David P. Johst
Corporate Executive Vice President,
General Counsel and
Chief Administrative Officer
Charles River Laboratories International, Inc.
251 Ballardvale St.
Wilmington, MA 01887
(Name and Address of Agent for Service)
(781) 222-6000
(Telephone Number, Including Area Code,
of Agent for Service)
Indicate
by check mark whether the registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, a smaller reporting
company or an emerging growth company. See the definitions of "large accelerated filer," "accelerated filer,"
"smaller reporting company" and "emerging growth company" in Rule 12b-2 of the Exchange Act.
Large accelerated filer
x
Accelerated filer
o
Non-accelerated filer
o
(Do not check if a smaller reporting company)
Smaller reporting company
o
Emerging growth company
o
If
an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for
complying with any new or revised financial accounting standards provided pursuant to Section 7(a)(2)(B) of the Securities Act.
o
CALCULATION OF REGISTRATION FEE
Title of
Securities to be Registered
Amount to
be Registered(1)
Proposed Maximum
Offering Price
Per Share(2)
Proposed Maximum
Aggregate
Offering Price(2)
Amount of
Registration Fee (2)(3)
Common Stock, par value $0.01 per share
7,198,598 shares
$103.81
$747,286,458.38
$93,037.17
(1)  This Registration
Statement on Form S-8 (this "
Registration Statement
") also relates to such indeterminate number of additional
shares of Charles River Laboratories International, Inc. Common Stock as may be required pursuant to the Registrant's 2018
Incentive Plan in the event of a reorganization, recapitalization, reclassification, stock dividend, stock split, reverse stock
split or other similar change in the Registrant's capital stock in accordance with Rule 416 under the Securities Act of 1933,
as amended (the "
Securities Act
").
(2)  Estimated solely
for the purpose of computing the registration fee pursuant to Rule 457(c) and 457(h) under the Securities Act, based on the average
of the high ($104.65) and low ($102.96) prices of the Registrant's Common Stock, $0.01 par value per share, reported on the
New York Stock Exchange on May 16, 2018.
(3)  Rounded up to the nearest penny.
PART I
INFORMATION REQUIRED IN THE SECTION 10(a)
PROSPECTUS
Item 1. PLAN INFORMATION.*
Item 2. REGISTRANT INFORMATION AND EMPLOYEE ANNUAL PLAN INFORMATION.*
* The
Section 10(a) prospectus being delivered by Charles River Laboratories International, Inc. (the "
Company
"
or the "
Registrant
") to participants in the Charles River Laboratories International, Inc. 2018 Incentive
Plan (the "
Plan
"), as required by Rule 428 under the Securities Act, has been prepared in accordance with
the requirements of Form S-8 and relates to shares of common stock, par value $0.01 per share, of the Company (the "
Common
Stock
") which have been reserved for issuance pursuant to the Plan. The information regarding the Plan required in the
Section 10(a) prospectus is included in documents (including the documents incorporated by reference pursuant to Item 3 of
Part II hereof) being maintained and delivered by the Company to participants in the Plan as required by Rule 428 under the
Securities Act. The Company shall provide to participants in the Plan a written statement advising them of the availability without
charge, upon written or oral request, of the documents incorporated by reference in Item 3 of Part II hereof, as is required by
Item 2 of Part I of Form S-8. The request shall be delivered to the Company, Attention: General Counsel at 251 Ballardvale
Street, Wilmington, MA, 01887, and the telephone number at that location is (781) 222-6000.
Part II.
Information
Required in the Registration Statement
Item 3.
Incorporation
of Documents by Reference
We hereby incorporate by reference
into this Registration Statement the following documents previously filed with the Securities and Exchange Commission (the "
Commission
")
pursuant to the Securities Exchange Act of 1934, as amended (the "
Exchange Act
"):
(a)
The Registrant's Annual Report on Form 10-K for the fiscal year ended December 30, 2017, as filed with the
Commission on February 13, 2018;
(b)
The Registrant's Quarterly Report on Form 10-Q for the period ended March 31, 2018, as filed with the Commission
on May 10, 2018;
(c)
The Registrant's Current Reports on Form 8-K, as filed with the Commission on January 16, 2018, February 13, 2018 (two
Current Reports), March 26, 2018, April 3, 2018 and May 14, 2018;
(d)
The Registrant's Definitive Proxy Statement for the 2018 annual meeting of shareholders held on May 8, 2018, as filed
with the Commission on March 29, 2018; and
(e)
The description of the Registrant's Common Stock contained in the Registration Statement on Form 8-A (File No. 001-15943)
filed with the Commission pursuant to Section 12 of the Exchange Act, including any amendment or report filed for the purpose
of updating such description.
All other documents filed by the Registrant
with the Commission pursuant to Sections 13(a), 13(c), 14 and 15(d) of the Exchange Act subsequent to the date of this Registration
Statement and prior to the filing of a post-effective amendment to this Registration Statement which indicates that all securities
offered have been sold or which de-registers all securities then remaining unsold, shall be deemed to be incorporated by reference
in this Registration Statement and to be a part hereof from the date of filing such documents (such documents, and the documents
enumerated above, being hereinafter referred to collectively as the "
Incorporated Documents
").
Any statement contained in an Incorporated
Document shall be deemed to be modified or superseded for purposes of this Registration Statement to the extent that a statement
contained herein or in any other subsequently filed Incorporated Document modifies or supersedes such statement. Any such statements
so modified or superseded shall not be deemed, except as so modified or superseded, to constitute a part of this Registration Statement.
Item 4. DESCRIPTION OF SECURITIES.
Not applicable.
Item 5.
Interest
of Named Experts and Counsel
David P. Johst, who has issued the opinion
of the Registrant's law department on the legality of the Common Stock offered hereby, is Corporate Executive Vice President, General
Counsel and Chief Administrative Officer of the Registrant. Mr. Johst owns shares of the Common Stock and holds employee stock
options to purchase the Common Stock, restricted stock, restricted stock units and performance share units. Mr. Johst is eligible
to participate in the Plan.
Item 6. INDEMNIFICATION OF DIRECTORS AND OFFICERS.
Section 145 of the Delaware General Corporation
Law ("
Delaware Law
") provides that a corporation may indemnify directors and officers as well as other employees
and individuals against expenses (including attorneys' fees), judgments, fines and amounts paid in settlement actually and
reasonably incurred by such person in connection with any threatened, pending or completed actions, suits or proceedings in which
such person is made a party by reason of such person being or having been a director, officer, employee or agent of the Registrant.
The Delaware Law provides that Section 145 is not exclusive of other rights to which those seeking indemnification may be entitled
under any bylaw, agreement, vote of stockholders or disinterested directors or otherwise. The Registrant's second amended
and restated certificate of incorporation provides for indemnification by the Registrant of its directors, officers and employees
to the fullest extent permitted by the Delaware Law.
Section 102(b)(7) of the Delaware Law permits
a corporation to provide in its certificate of incorporation that a director of the corporation shall not be personally liable
to the corporation or its stockholders for monetary damages for breach of fiduciary duty as a director, except for liability for
any breach of the director's duty of loyalty to the corporation or its stockholders, for acts or omissions not in good faith or
which involve intentional misconduct or a knowing violation of law, for unlawful payments of dividends or unlawful stock repurchases,
redemptions or other distributions, or for any transaction from which the director derived an improper personal benefit. The Registrant's
second amended and restated certificate of incorporation provides for such limitation of liability.
The Registrant maintains standard
policies of insurance under which coverage is provided to its directors and officers against loss rising from claims made by reason
of breach of duty, misstatement, error or omission committed in their capacity as directors or officers of the Registrant. Such
policies of insurance also provide coverage to the Registrant with respect to payments which may be made by the Registrant to such
officers and directors pursuant to the above indemnification provision or otherwise as a matter of law.
Item 7. EXEMPTION FROM REGISTRATION CLAIMED.
Not Applicable.
Item 8.
Exhibits.
The following exhibits are filed as part
of this Registration Statement:
Exhibit
        No.
Description
Filed
        with this Form S-8
Incorporated by Reference
Form
Filing Date
Exhibit No.
4.1
Form of certificate representing shares of common stock, $0.01 par value per share
S-1
June 23, 2000
4.1
4.2
Second Amended and Restated Certificate of Incorporation of Charles River Laboratories International, Inc.
S-1
June 23, 2000
3.1
4.3
Fifth Amended and Restated By-Laws of Charles River Laboratories International, Inc.
8-K
May 16, 2016
3.2
5.1
Opinion of David P. Johst, Esq., as to the legality of the securities being registered
*
23.1
Consent of David P. Johst, Esq. (included in Exhibit 5.1)
*
23.2
Consent of PricewaterhouseCoopers LLP
*
24.1
Power of Attorney (included on the signature page of this Registration Statement)
*
99.1
Charles River Laboratories International, Inc. 2018 Incentive Plan
10-Q
May 10, 2018
10.2
Item 9. UNDERTAKINGS.
(a)  The
Registrant hereby undertakes:
(1)  to
file, during any period in which offers or sales are being made, a post-effective amendment to this Registration Statement:
(i)  To
include any prospectus required by Section 10(a)(3) of the Securities Act;
(ii)   To
reflect in the prospectus any facts or events arising after the effective date of the Registration Statement (or the most recent
post-effective amendment thereof) which, individually or in the aggregate, represent a fundamental change in the information set
forth in the Registration Statement. Notwithstanding the foregoing, any increase or decrease in volume of securities offered (if
the total dollar value of securities offered would not exceed that which was registered) and any deviation from the low or high
end of the estimated maximum offering range may be reflected in the form of prospectus filed with the Commission pursuant to Rule 424(b)
if, in the aggregate, the changes in volume and price represent no more than a 20 percent change in the maximum aggregate
offering price set forth in the "Calculation of Registration Fee" table in the effective Registration Statement;
(iii) To include any material information
with respect to the plan of distribution not previously disclosed in the Registration Statement or any material change to such
information in the Registration Statement;
PROVIDED, HOWEVER, that paragraphs (a)(1)(i) and
(a)(1)(ii) do not apply if the information required to be included in a post-effective amendment by those paragraphs is contained
in periodic reports filed with or furnished to the Commission by the Registrant pursuant to Section 13 or 15(d) of the Exchange
Act that are incorporated by reference in the Registration Statement.
(2)  That,
for the purpose of determining any liability under the Securities Act, each such post-effective amendment shall be deemed to be
a new registration statement relating to the securities offered therein, and the offering of such securities at that time shall
be deemed to be the initial
bona fide
offering thereof.
(3)   To
remove from registration by means of a post-effective amendment any of the securities being registered which remain unsold at the
termination of the offering.
(b)  The
Registrant hereby undertakes that, for purposes of determining any liability under the Securities Act, each filing of the Registrant's
annual report pursuant to Section 13(a) or 15(d) of the Exchange Act (and, where applicable, each filing of an employee benefit
plan's annual report pursuant to Section 15(d) of the Exchange Act) that is incorporated by reference in the Registration
Statement shall be deemed to be a new registration statement relating to the securities offered therein, and the offering of such
securities at that time shall be deemed to be the initial
bona fide
offering thereof.
(c)  Insofar
as indemnification for liabilities arising under the Securities Act may be permitted to directors, officers and controlling persons
of the Registrant pursuant to the foregoing provisions, or otherwise, the Registrant has been advised that in the opinion of the
Commission such indemnification is against public policy as expressed in the Act and is, therefore, unenforceable. In the event
that a claim for indemnification against such liabilities (other than the payment by the Registrant of expenses incurred or paid
by a director, officer or controlling person of the Registrant in the successful defense of any action, suit or proceeding) is
asserted by such director, officer or controlling person in connection with the securities being registered, the Registrant will,
unless in the opinion of its counsel the matter has been settled by controlling precedent, submit to a court of appropriate jurisdiction
the question whether such indemnification by it is against public policy as expressed in the Securities Act and will be governed
by the final adjudication of such issue.
SIGNATURES
Pursuant
to the requirements of the Securities Act, the Registrant certifies that it has reasonable grounds to believe that it meets all
of the requirements for filing on Form S-8 and has duly caused this Registration Statement to be signed on its behalf by the
undersigned, thereunto duly authorized, in the city of Boston, Commonwealth of Massachusetts on May 18, 2018.
CHARLES RIVER LABORATORIES INTERNATIONAL, INC.
By:
/s/  JAMES C. FOSTER
James C.
Foster
Chairman and Chief Executive Officer
POWER OF ATTORNEY AND SIGNATURES
We,
the undersigned officers and directors of Charles River Laboratories International, Inc., hereby severally constitute and
appoint James C. Foster, David P. Johst and David R. Smith and each of them singly, as true and lawful attorneys-in-fact, with
full power of substitution, to sign for us in our names in the capacities indicated below, all additional amendments (including
post-effective amendments) to this Registration Statement, and generally to do all things in our names and on our behalf in such
capacities to enable Charles River Laboratories International, Inc. to comply with the provisions of the Securities Act, and
all applicable requirements of the Commission.
Pursuant to the requirements of the Securities
Act, this Registration Statement has been signed by the following persons in the capacities and on the dates indicated.
Signatures
Title
Date
By:
/s/ JAMES C. FOSTER
Chairman and Chief Executive Officer
May 18, 2018
James C. Foster
By:
/s/ DAVID R. SMITH
Corporate Executive Vice President and
May 18, 2018
David R. Smith
Chief Financial Officer
By:
/s/ MICHAEL G. KNELL
Corporate Senior Vice President and
May 18, 2018
Michael G. Knell
Chief Accounting Officer
By:
/s/ ROBERT J. BERTOLINI
Director
May 18, 2018
Robert J. Bertolini
By:
/s/ STEPHEN D. CHUBB
Director
May 18, 2018
Stephen D. Chubb
By:
/s/ DEBORAH T. KOCHEVAR
Director
May 18, 2018
Deborah T. Kochevar
By:
/s/ MARTIN W. MACKAY
Director
May 18, 2018
Martin W. Mackay
By:
/s/ JEAN-PAUL MANGEOLLE
Director
May 18, 2018
Jean-Paul Mangeolle
By:
/s/ GEORGE E. MASSARO
Director
May 18, 2018
George E. Massaro
By:
/s/ GEORGE M. MILNE, JR.
Director
May 18, 2018
George M. Milne, Jr.
By:
/s/ C. RICHARD REESE
Director
May 18, 2018
C. Richard Reese
By:
Director
Craig B. Thompson
By:
/s/ RICHARD F. WALLMAN
Director
May 18, 2018
Richard F. Wallman
Exhibit Index
Exhibit
        No.
Description
Filed
        with this Form S-8
Incorporated by Reference
Form
Filing Date
Exhibit No.
4.1
Form of certificate representing shares of common stock, $0.01 par value per share
S-1
June 23, 2000
4.1
4.2
Second Amended and Restated Certificate of Incorporation of Charles River Laboratories International, Inc.
S-1
June 23, 2000
3.1
4.3
Fifth Amended and Restated By-Laws of Charles River Laboratories International, Inc.
8-K
May 16, 2016
3.2
5.1
Opinion of David P. Johst, Esq., as to the legality of the securities being registered
*
23.1
Consent of David P. Johst, Esq. (included in Exhibit 5.1)
*
23.2
Consent of PricewaterhouseCoopers LLP
*
24.1
Power of Attorney (included on the signature page of this Registration Statement)
*
99.1
Charles River Laboratories International, Inc. 2018 Incentive Plan
10-Q
May 10, 2018
10.2