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<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><FONT STYLE="font-size: 10pt">As filed
with the Securities and Exchange Commission on </FONT>December 13<FONT STYLE="font-size: 10pt">, 2017</FONT></P>

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<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: right; border-bottom: Black 4.5pt double">Registration
No. 333-_____</P>

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<P STYLE="font: bold 14pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center">SECURITIES AND EXCHANGE COMMISSION</P>

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<P STYLE="font: bold 12pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center">Washington, D.C. 20549</P>

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<P STYLE="font: bold 14pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center">FORM S-8</P>

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<P STYLE="font: bold 12pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center">REGISTRATION
STATEMENT UNDER<BR> THE SECURITIES ACT OF 1933</P>

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<P STYLE="font: bold 14pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center">SHIRE PLC</P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center">(Exact Name of Registrant
as Specified in its Charter)</P>

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<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
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    <TD STYLE="width: 25%; text-align: center"><FONT STYLE="font-size: 10pt"><B>Jersey (Channel Islands)</B></FONT></TD>
    <TD STYLE="width: 50%; text-align: right">&nbsp;</TD>
    <TD STYLE="width: 25%; text-align: center"><FONT STYLE="font-size: 10pt"><B>98-0601486</B></FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: center"><FONT STYLE="font-size: 10pt">(State or Other Jurisdiction of Incorporation or Organization)</FONT></TD>
    <TD STYLE="text-align: right">&nbsp;</TD>
    <TD STYLE="text-align: center"><FONT STYLE="font-size: 10pt">(I.R.S. Employer</FONT><BR>
<FONT STYLE="font-size: 10pt">Identification No.)</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: right">&nbsp;</TD>
    <TD>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>Miesian Plaza</B></P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"></P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>Blocks 2 and 3</B></P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"></P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>50-58 Baggot Street Lower</B></P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"></P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>Dublin 2, D02 Y754</B></P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"></P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>Ireland</B><BR>
        (Address of Principal Executive Offices)</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"></P></TD>
    <TD STYLE="text-align: right">&nbsp;</TD></TR>
</TABLE>
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<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

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<P STYLE="font: bold 14pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center">The Shire Executive Annual Incentive
Plan</P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center">(Full Titles of the Plan(s))</P>

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    <TD>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>William Mordan<BR>
        General Counsel and Company Secretary<BR>
        Shire PLC<BR>
        Miesian Plaza</B></P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"></P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>Blocks 2 and 3</B></P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"></P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>50-58 Baggot Street Lower</B></P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"></P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>Dublin 2, D02 Y754</B></P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"></P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>Ireland</B></P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"></P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">(Name and Address of Agent for Service)</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>+353 1 609 6000</B><BR>
        (Telephone Number, Including Area Code, of Agent for Service)</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"></P></TD>
    </TR>
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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center"><I>With copies to:</I> &nbsp;</P>

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    <TD STYLE="width: 33%">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; text-indent: -4.2pt"><B>John B. Meade, Esq.</B></P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; text-indent: -4.2pt"></P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; text-indent: -4.2pt"><B>Davis Polk &amp;
        Wardwell LLP</B></P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; text-indent: -4.2pt"></P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; text-indent: -4.2pt"><B>450 Lexington Avenue</B></P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; text-indent: -4.2pt"></P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; text-indent: -4.2pt"><B>New York, NY 0017</B></P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; text-indent: -4.2pt"></P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; text-indent: -4.2pt"><B>(212) 450-4000</B></P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; text-indent: -4.2pt"></P></TD>
    <TD STYLE="width: 34%; background-color: white; font-size: 12pt; text-align: justify">&nbsp;</TD>
    <TD STYLE="vertical-align: top; width: 33%; background-color: white">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; text-indent: -4.2pt"><B>Kyoko Takahashi
        Lin, Esq.</B></P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; text-indent: -4.2pt"></P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; text-indent: -4.2pt"><B>Davis Polk &amp;
        Wardwell LLP</B></P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; text-indent: -4.2pt"></P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; text-indent: -4.2pt"><B>450 Lexington Avenue</B></P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; text-indent: -4.2pt"></P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; text-indent: -4.2pt"><B>New York, NY 10017</B></P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; text-indent: -4.2pt"></P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; text-indent: -4.2pt"><B>(212) 450-4000</B></P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; text-indent: -4.2pt"></P></TD></TR>
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<P STYLE="margin-top: 0; margin-bottom: 0">&nbsp;&nbsp;</P>

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    <TD COLSPAN="4" STYLE="text-align: left; font-size: 10pt; padding: 2pt"><FONT STYLE="font-size: 10pt">Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, or a smaller reporting company.</FONT><BR>
<FONT STYLE="font-size: 10pt">See the definitions of &ldquo;large accelerated filer,&rdquo; &ldquo;accelerated filer&rdquo; and &ldquo;smaller reporting company&rdquo; in Rule 12b-2 of the Exchange Act.</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding: 2pt 2pt 2pt 0.375in; text-align: left; font-size: 10pt"><FONT STYLE="font-size: 10pt">Large accelerated filer <FONT STYLE="font-family: Times New Roman, Times, Serif">&#9746;</FONT></FONT></TD>
    <TD COLSPAN="2" STYLE="text-align: left; font-size: 10pt; padding: 2pt"><FONT STYLE="font-size: 10pt">Accelerated filer <FONT STYLE="font-family: Times New Roman, Times, Serif">&#9744;</FONT></FONT></TD>
    <TD STYLE="text-align: center; font-size: 10pt; padding: 2pt">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD COLSPAN="2" STYLE="padding: 2pt 2pt 2pt 0.375in; text-align: left; font-size: 10pt"><FONT STYLE="font-size: 10pt">Non-accelerated filer <FONT STYLE="font-family: Times New Roman, Times, Serif">&#9744;</FONT> (Do not check if a smaller reporting company)</FONT></TD>
    <TD COLSPAN="2" STYLE="text-align: center; font-size: 10pt; padding: 2pt"><FONT STYLE="font-size: 10pt">Smaller reporting company <FONT STYLE="font-family: Times New Roman, Times, Serif">&#9744;</FONT></FONT></TD></TR>
<TR>
    <TD STYLE="width: 39%; padding: 2pt">&nbsp;</TD>
    <TD STYLE="width: 27%; padding: 2pt"></TD>
    <TD STYLE="width: 10%; padding: 2pt"></TD>
    <TD STYLE="width: 24%; padding: 2pt"></TD></TR>
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<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-transform: uppercase; text-align: center">CALCULATION
OF REGISTRATION FEE</P>

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<TR STYLE="vertical-align: bottom">
    <TD STYLE="width: 44%; border-top: Black 1.5pt solid; border-right: Black 1.5pt solid; border-bottom: Black 1.5pt solid; padding: 1pt; text-align: center; font-size: 10pt"><FONT STYLE="font-size: 10pt"><B>Title of Each Class of Securities to be Registered</B></FONT></TD>
    <TD STYLE="width: 14%; border-top: Black 1.5pt solid; border-right: Black 1.5pt solid; border-bottom: Black 1.5pt solid; padding: 1pt; text-align: center; font-size: 10pt"><FONT STYLE="font-size: 10pt"><B>Amount to Be Registered (2)</B></FONT></TD>
    <TD STYLE="width: 14%; border-top: Black 1.5pt solid; border-right: Black 1.5pt solid; border-bottom: Black 1.5pt solid; padding: 1pt; text-align: center; font-size: 10pt"><FONT STYLE="font-size: 10pt"><B>Proposed Maximum Offering Price</B></FONT><BR>
<FONT STYLE="font-size: 10pt"><B>Per Share (3)(4)</B></FONT></TD>
    <TD STYLE="width: 14%; border-top: Black 1.5pt solid; border-right: Black 1.5pt solid; border-bottom: Black 1.5pt solid; padding: 1pt; text-align: center; font-size: 10pt"><FONT STYLE="font-size: 10pt"><B>Proposed Maximum Aggregate Offering Price</B></FONT><BR>
<FONT STYLE="font-size: 10pt"><B>(3)(4)</B></FONT></TD>
    <TD STYLE="width: 14%; border-top: Black 1.5pt solid; border-bottom: Black 1.5pt solid; padding: 1pt; text-align: center; font-size: 10pt"><FONT STYLE="font-size: 10pt"><B>Amount of Registration Fee (4)</B></FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="border-right: Black 1.5pt solid; border-bottom: Black 1.5pt solid; padding: 1pt; text-align: justify; font-size: 10pt"><FONT STYLE="font-size: 10pt">Ordinary Shares, nominal value &pound;0.05 per Ordinary Share, to be issued under the Shire Executive Annual Incentive Plan (1) </FONT></TD>
    <TD STYLE="border-right: Black 1.5pt solid; border-bottom: Black 1.5pt solid; padding: 1pt; text-align: center; font-size: 10pt"><FONT STYLE="font-size: 10pt">9,400</FONT></TD>
    <TD STYLE="border-right: Black 1.5pt solid; border-bottom: Black 1.5pt solid; padding: 1pt; text-align: center; font-size: 10pt">$47.24</TD>
    <TD STYLE="border-right: Black 1.5pt solid; border-bottom: Black 1.5pt solid; padding: 1pt; text-align: center; font-size: 10pt">$444,056</TD>
    <TD STYLE="border-bottom: Black 1.5pt solid; padding: 1pt; text-align: center; font-size: 10pt">$55.28</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="border-right: Black 1.5pt solid; border-bottom: Black 2pt solid; padding: 1pt; text-align: justify; font-size: 10pt"><FONT STYLE="font-size: 10pt">American Depository Shares, each representing three Ordinary Shares (1) (&ldquo;ADSs&rdquo;)</FONT></TD>
    <TD STYLE="border-right: Black 1.5pt solid; border-bottom: Black 2pt solid; padding: 1pt; text-align: center; font-size: 10pt"><FONT STYLE="font-size: 10pt">3,134</FONT></TD>
    <TD STYLE="border-right: Black 1.5pt solid; border-bottom: Black 2pt solid; padding: 1pt; text-align: center; font-size: 10pt">-</TD>
    <TD STYLE="border-right: Black 1.5pt solid; border-bottom: Black 2pt solid; padding: 1pt; text-align: center; font-size: 10pt">-</TD>
    <TD STYLE="padding: 1pt; text-align: center; font-size: 10pt; border-bottom: Black 2pt solid">-</TD></TR>
</TABLE>
<P STYLE="margin-top: 0; margin-bottom: 0">&nbsp;</P>

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<TD STYLE="width: 0"></TD><TD STYLE="width: 0.3in">(1)</TD><TD STYLE="text-align: justify">The Ordinary Shares of Shire plc (the &ldquo;Company&rdquo; or the &ldquo;Registrant&rdquo;) may
be represented by the Registrant&rsquo;s ADSs, evidenced by American Depositary Receipts (&ldquo;ADRs&rdquo;), each representing
three Ordinary Shares. Separate Registration Statements on Form F-6 were filed with the Securities and Exchange Commission (the
&ldquo;Commission&rdquo;) on November 14, 2014 (with a Post-Effective Amendment No. 1 filed with the Commission on Form F-6 POS
on May 8, 2017) and May 4, 2016, for the registration of ADSs evidenced by ADRs issuable upon deposit of Ordinary Shares.</TD></TR></TABLE>

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<TD STYLE="width: 0"></TD><TD STYLE="width: 0.3in">(2)</TD><TD STYLE="text-align: justify">Pursuant to Rule 416(a) under the Securities Act of 1933, as amended (the &ldquo;Securities Act&rdquo;),
this Registration Statement shall also cover any additional Ordinary Shares of the Registrant that may become issuable under the
Shire Executive Annual Incentive Plan as a result of any stock split, stock dividend or similar transaction.</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

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<TD STYLE="width: 0"></TD><TD STYLE="width: 0.3in">(3)</TD><TD STYLE="text-align: justify">Estimated pursuant to Rule 457(c) and
Rule 457(h) under the Securities Act, solely for the purpose of computing the registration fee, based on the average of the high
and low prices reported for an Ordinary Share on the London Stock Exchange on December 7, 2017 (&pound;35.47), converted from
Pounds Sterling to U.S. Dollars at the currency cross rate at the close of the NASDAQ Stock Exchange on December 12, 2017, as
reported by the Wall Street Journal (&pound;1=U.S.$1.3318).</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

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<TD STYLE="width: 0"></TD><TD STYLE="width: 0.3in">(4)</TD><TD STYLE="text-align: justify">Rounded up to the nearest cent.</TD></TR></TABLE>

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<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-transform: uppercase; text-align: center">EXPLANATORY
NOTE</P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.5in">Shire plc, a company
organized under the laws of Jersey (Channel Islands) (the &ldquo;Company&rdquo; or the &ldquo;Registrant&rdquo;), is filing this
Registration Statement on Form S-8 with respect to up to 9,400 of its Ordinary Shares, nominal value &pound;0.05 per share, to
be issued under the Shire Executive Annual Incentive Plan (the &ldquo;EAIP&rdquo;). <FONT STYLE="font-family: Times New Roman, Times, Serif">The
Company filed a Form S-8 on March 1, 2010 (File No. 333-165137), which registered 300,000 Ordinary Shares for issuance under the
EAIP.&nbsp; </FONT>Pursuant to General Instruction E to Form S-8, the contents of the previous registration statements relating
to the EAIP (File No. 333-165137) are incorporated by reference herein and made a part of this Registration Statement, except as
amended hereby.</P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>PART II</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>INFORMATION REQUIRED IN THE</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>REGISTRATION STATEMENT</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
<TR STYLE="vertical-align: top">
    <TD STYLE="width: 0.75in; text-align: justify; font-size: 10pt"><B>ITEM 3.</B></TD>
    <TD STYLE="text-align: justify; font-size: 10pt"><FONT STYLE="text-transform: uppercase"><B>INCORPORATION OF DOCUMENTS BY REFERENCE</B></FONT><B>.</B></TD></TR>
</TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.5in">The reports listed
below have been filed with or furnished to Commission by the Registrant and are incorporated herein by reference to the extent
not superseded by documents or reports subsequently filed or furnished:</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.3in">(a)<FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">&nbsp;&nbsp;&nbsp;
</FONT>The Registrant&rsquo;s Annual Report on Form 10-K for the fiscal year ended December 31, 2016, filed with the Commission
on February 22, 2017.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.3in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.3in">(b)<FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">&nbsp;&nbsp;&nbsp;
</FONT>All reports filed pursuant to Section 13(a) or 15(d) of the Securities Exchange Act of 1934, as amended, (the &ldquo;Exchange
Act&rdquo;) since December 31, 2016.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.3in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.3in">(c)<FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">&nbsp;&nbsp;&nbsp;
</FONT>The description of the Registrant&rsquo;s Ordinary Shares and ADRs evidencing ADSs contained in the Registrant&rsquo;s Current
Report on Form 8-K, filed with the Commission on May 23, 2008, including any amendments or supplements thereto.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.3in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.5in">In addition, all documents
filed by the Registrant pursuant to Sections 13(a), 13(c), 14 and 15(d) of the Exchange Act, subsequent to the date of this Registration
Statement and prior to the filing of a post-effective amendment to this Registration Statement which indicates that all securities
offered have been sold or which deregisters all securities then remaining unsold, shall be deemed to be incorporated by reference
in this Registration Statement and to be a part hereof from the date of the filing of such documents.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.5in">Any statement contained
in a document incorporated or deemed to be incorporated by reference herein shall be deemed to be modified or superseded for purposes
of this Registration Statement to the extent that a statement contained herein, (or in any other subsequently filed document which
also is incorporated or deemed to be incorporated by reference herein), modifies or supersedes such statement. Any such statement
so modified or superseded shall not be deemed, except as so modified or superseded, to constitute a part of this Registration Statement.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.5in"></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.5in"></P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
<TR STYLE="vertical-align: top">
    <TD STYLE="font-size: 12pt; text-align: justify; width: 0.75in"><FONT STYLE="font-size: 10pt"><B>ITEM 5.</B></FONT></TD>
    <TD>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0.8pt 0pt 0; text-align: justify"><B>INTERESTS OF NAMED EXPERTS
        AND COUNSEL.</B></P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0.8pt 0pt 0; text-align: justify">&nbsp;</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0.8pt 0pt 0; text-align: justify">Not applicable.</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0.8pt 0pt 0; text-align: justify"></P></TD></TR>
</TABLE>
<P STYLE="margin-top: 0; margin-bottom: 0">&nbsp;</P>

<P STYLE="margin-top: 0; margin-bottom: 0"></P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
<TR STYLE="vertical-align: top">
    <TD STYLE="font-size: 12pt; text-align: justify; width: 0.75in"><FONT STYLE="font-size: 10pt"><B>ITEM 8.</B></FONT></TD>
    <TD>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0.8pt 0pt 0; text-align: justify"><B>EXHIBITS.</B></P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0.8pt 0pt 0; text-align: justify">&nbsp;</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0.8pt 0pt 0; text-align: justify">The following exhibits are included
        or incorporated herein by reference:</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0.8pt 0pt 0; text-align: justify"></P></TD></TR>
</TABLE>
<P STYLE="margin-top: 0; margin-bottom: 0">&nbsp;&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: justify; width: 0.75in"><FONT STYLE="font-size: 10pt">4.1</FONT></TD>
    <TD><FONT STYLE="font-size: 10pt">Memorandum of Association as adopted by special resolution passed on April 10, 2008 and
amended by special resolution on September 24, 2008 and by further special resolution on April 28, 2016, and Articles of Association
as</FONT></TD></TR>
</TABLE>

<P STYLE="margin: 0">&nbsp;</P>

<P STYLE="margin: 0"></P>

<P STYLE="margin: 0">&nbsp;</P>

<P STYLE="margin: 0"></P>

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<P STYLE="margin: 0">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: justify">&nbsp;</TD>
    <TD>amended and adopted by special resolution on April 25, 2017, incorporated by reference to Registration Statement on Form S-8 filed on December 13, 2017.</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: justify; width: 0.75in">&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: justify"><FONT STYLE="font-size: 10pt">4.2</FONT></TD>
    <TD STYLE="text-align: justify"><FONT STYLE="font-size: 10pt">Amended and Restated Deposit Agreement, dated as of May 23, 2011, among the Company, Citibank, N.A., as depositary, and all holders and beneficial owners from time to time of ADRs issued thereunder evidencing ADSs, incorporated by reference to Registration Statement on Form F-6 filed on November 14, 2014.</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: justify">&nbsp;</TD>
    <TD STYLE="text-align: justify">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: justify"><FONT STYLE="font-size: 10pt">5.1</FONT></TD>
    <TD STYLE="text-align: justify"><FONT STYLE="font-size: 10pt">Opinion of Mourant Ozannes, as to the legality of the Ordinary Shares being issued pursuant hereto.</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: justify">&nbsp;</TD>
    <TD STYLE="text-align: justify">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: justify"><FONT STYLE="font-size: 10pt">23.1</FONT></TD>
    <TD STYLE="text-align: justify"><FONT STYLE="font-size: 10pt">Consent of Deloitte LLP, Independent Registered Public Accounting Firm of Shire plc.</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: justify">&nbsp;</TD>
    <TD STYLE="text-align: justify">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: justify"><FONT STYLE="font-size: 10pt">23.2</FONT></TD>
    <TD STYLE="text-align: justify"><FONT STYLE="font-size: 10pt">Consent of Deloitte LLP, Independent Registered Public Accounting Firm of Shire plc.</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: justify">&nbsp;</TD>
    <TD STYLE="text-align: justify">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: justify"><FONT STYLE="font-size: 10pt">23.3</FONT></TD>
    <TD STYLE="text-align: justify"><FONT STYLE="font-size: 10pt">Consent of Mourant Ozannes (included in Exhibit 5.1).</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: justify">&nbsp;</TD>
    <TD STYLE="text-align: justify">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: justify"><FONT STYLE="font-size: 10pt">24.1</FONT></TD>
    <TD STYLE="text-align: justify"><FONT STYLE="font-size: 10pt">Power of Attorney (included in the signature pages hereof).</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: justify">&nbsp;</TD>
    <TD STYLE="text-align: justify">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: justify"><FONT STYLE="font-size: 10pt">99.1</FONT></TD>
    <TD STYLE="text-align: justify"><FONT STYLE="font-size: 10pt">Shire Executive Annual Incentive Plan (filed herewith).</FONT></TD></TR>
</TABLE>


<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.5in"></P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.5in"></P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-transform: uppercase; text-align: center">EXHIBIT
INDEX</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-transform: uppercase; text-align: center">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
<TR STYLE="vertical-align: top">
    <TD STYLE="width: 12%; border-bottom: Black 1pt solid; text-align: justify"><FONT STYLE="font-size: 10pt">Exhibit</FONT><BR>
<FONT STYLE="font-size: 10pt">Number</FONT></TD>
    <TD STYLE="width: 2%; text-align: justify">&nbsp;</TD>
    <TD STYLE="width: 86%; text-align: justify">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: justify">&nbsp;</TD>
    <TD STYLE="text-align: justify">&nbsp;</TD>
    <TD STYLE="text-align: justify">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: justify"><FONT STYLE="font-size: 10pt">4.1</FONT></TD>
    <TD STYLE="text-align: justify">&nbsp;</TD>
    <TD STYLE="text-align: left"><A HREF="http://www.sec.gov/Archives/edgar/data/936402/000095010317012410/dp84077_ex0401.htm">Memorandum of Association as adopted by special resolution passed on April 10, 2008 and amended by special resolution on September 24, 2008 and by further special resolution on April 28, 2016, and Articles of Association as amended and adopted by special resolution on April 25, 2017, incorporated by reference to Registration Statement on Form S-8 filed on December 13, 2017.</A></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: justify">&nbsp;</TD>
    <TD STYLE="text-align: justify">&nbsp;</TD>
    <TD STYLE="text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: justify"><FONT STYLE="font-size: 10pt">4.2</FONT></TD>
    <TD STYLE="text-align: justify">&nbsp;</TD>
    <TD STYLE="text-align: justify"><A HREF="http://www.sec.gov/Archives/edgar/data/936402/000119380514002188/e612802_ex99-a.htm">Amended and Restated Deposit Agreement, dated as of May 23, 2011, among the Company, Citibank, N.A., as depositary, and all holders and beneficial owners from time to time of ADRs issued thereunder evidencing ADSs, incorporated by reference to Registration Statement on Form F-6 filed on November 14, 2014.</A></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: justify">&nbsp;</TD>
    <TD STYLE="text-align: justify">&nbsp;</TD>
    <TD STYLE="text-align: justify">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: justify"><FONT STYLE="font-size: 10pt">5.1</FONT></TD>
    <TD STYLE="text-align: justify">&nbsp;</TD>
    <TD STYLE="text-align: justify"><A HREF="dp84078_ex0501.htm">Opinion of Mourant Ozannes, as to the legality of the Ordinary Shares being issued pursuant hereto.</A></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: justify">&nbsp;</TD>
    <TD STYLE="text-align: justify">&nbsp;</TD>
    <TD STYLE="text-align: justify">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: justify">23.1</TD>
    <TD STYLE="text-align: justify">&nbsp;</TD>
    <TD STYLE="text-align: justify"><A HREF="dp84078_ex2301.htm">Consent of Deloitte LLP, Independent Registered Public Accounting Firm of Shire plc.</A></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: justify">&nbsp;</TD>
    <TD STYLE="text-align: justify">&nbsp;</TD>
    <TD STYLE="text-align: justify">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: justify">23.2</TD>
    <TD STYLE="text-align: justify">&nbsp;</TD>
    <TD STYLE="text-align: justify"><A HREF="dp84078_ex2302.htm">Consent of Deloitte LLP, Independent Registered Public Accounting Firm of Shire plc.</A></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: justify">&nbsp;</TD>
    <TD STYLE="text-align: justify">&nbsp;</TD>
    <TD STYLE="text-align: justify">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: justify">23.3</TD>
    <TD STYLE="text-align: justify">&nbsp;</TD>
    <TD STYLE="text-align: justify"><A HREF="dp84078_ex0501.htm">Consent of Mourant Ozannes (included in Exhibit 5.1).</A></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: justify">&nbsp;</TD>
    <TD STYLE="text-align: justify">&nbsp;</TD>
    <TD STYLE="text-align: justify">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: justify"><FONT STYLE="font-size: 10pt">24.1</FONT></TD>
    <TD STYLE="text-align: justify">&nbsp;</TD>
    <TD STYLE="text-align: justify"><A HREF="#a_001">Power of Attorney (included in the signature pages hereof).</A></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: justify">&nbsp;</TD>
    <TD STYLE="text-align: justify">&nbsp;</TD>
    <TD STYLE="text-align: justify">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: justify"><FONT STYLE="font-size: 10pt">99.1 </FONT></TD>
    <TD STYLE="text-align: justify">&nbsp;</TD>
    <TD STYLE="text-align: justify"><A HREF="dp84078_ex9901.htm">Shire Executive Annual Incentive Plan (filed herewith).</A></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: justify">&nbsp;</TD>
    <TD STYLE="text-align: justify">&nbsp;</TD>
    <TD STYLE="text-align: justify; border-bottom: Black 1pt solid">&nbsp;</TD></TR>
</TABLE>

<P STYLE="margin-top: 0; margin-bottom: 0">&nbsp;</P>


<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.5in"></P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.5in"></P>



<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-transform: uppercase; text-align: center">SIGNATURES</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-transform: uppercase; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 21.55pt">Pursuant to the
requirements of the Securities Act of 1933, as amended, the Registrant certifies that it has reasonable grounds to believe that
it meets all of the requirements for filing on Form S-8 and has duly caused this Registration Statement to be signed on its behalf
by the undersigned, thereunto duly authorized, in Lexington, Massachusetts, on the 13<SUP>th</SUP> day of December, 2017.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 21.55pt">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="border-collapse: collapse; font: 10pt Times New Roman, Times, Serif; width: 100%">
<TR STYLE="vertical-align: top; text-align: left">
    <TD>&nbsp;</TD>
    <TD COLSPAN="3">SHIRE PLC</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD>&nbsp;</TD>
    <TD COLSPAN="3">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD STYLE="width: 60%">&nbsp;</TD>
    <TD STYLE="width: 2%">&nbsp;</TD>
    <TD STYLE="width: 2%">&nbsp;</TD>
    <TD STYLE="width: 36%">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD>&nbsp;</TD>
    <TD>By&nbsp;&nbsp;&nbsp;&nbsp;</TD>
    <TD COLSPAN="2" STYLE="border-bottom: Black 1pt solid">/s/&nbsp;&nbsp;Flemming Ornskov, M.D.</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>Name:&nbsp;&nbsp;&nbsp;&nbsp;</TD>
    <TD>Flemming Ornskov, M.D.</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>Title:</TD>
    <TD>Chief Executive Officer</TD></TR>
</TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 21.55pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 21.55pt">&nbsp;</P>


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<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-transform: uppercase; text-align: center"><A NAME="a_001"></A>POWER OF
ATTORNEY</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-transform: uppercase; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 21.55pt">KNOW ALL PERSONS
BY THESE PRESENTS, that each person whose signature appears below, constitutes and appoints each of Flemming Ornskov, M.D. and
William Mordan as his or her true and lawful attorney-in-fact and agent, upon the action of such appointee, with full power of
substitution and resubstitution, to do any and all acts and things and execute, in the name of the undersigned, any and all instruments
which each of said attorneys-in-fact and agents may deem necessary or advisable in order to enable Shire plc to comply with the
Securities Act of 1933, as amended (the &ldquo;Securities Act&rdquo;), and any requirements of the Securities and Exchange Commission
(the &ldquo;Commission&rdquo;) in respect thereof, in connection with the filing with the Commission of this registration statement
on Form S-8 (this &ldquo;Registration Statement&rdquo;) under the Securities Act, including specifically but without limitation,
power and authority to sign the name of the undersigned to such Registration Statement, and any amendments to such Registration
Statement (including post-effective amendments), which amendments may make such other changes in this Registration Statement as
such attorney-in-fact deems appropriate, and any registration statements filed by the Registrant pursuant to Rule 462(b) of the
Securities Act relating thereto, and to file the same with all exhibits thereto and other documents in connection therewith, with
the Commission, to sign any and all applications, registration statements, notices or other documents necessary or advisable to
comply with applicable state securities laws, and to file the same, together with other documents in connection therewith with
the appropriate state securities authorities, granting unto each of said attorneys-in-fact and agents full power and authority
to do and to perform each and every act and thing requisite or necessary to be done in and about the premises, as fully and to
all intents and purposes as the undersigned might or could do in person, hereby ratifying and confirming all that each of said
attorneys-in-fact and agents may lawfully do or cause to be done by virtue hereof.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 21.55pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">Pursuant to the requirements of the Securities
Act, this Registration Statement has been signed by the following persons in the following capacities and on the date indicated
above.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"></P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
<TR>
    <TD STYLE="vertical-align: bottom; width: 31%; font-size: 12pt"><FONT STYLE="font-size: 10pt"><U>Signature</U></FONT></TD>
    <TD STYLE="vertical-align: bottom; width: 10%; font-size: 12pt; text-align: center">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; width: 37%; font-size: 12pt"><FONT STYLE="font-size: 10pt"><U>Title</U></FONT></TD>
    <TD STYLE="vertical-align: top; width: 22%; font-size: 12pt"><FONT STYLE="font-size: 10pt"><U>Date</U></FONT></TD></TR>
<TR>
    <TD STYLE="vertical-align: bottom; font-size: 12pt">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; font-size: 12pt; text-align: center">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; font-size: 12pt">&nbsp;</TD>
    <TD STYLE="vertical-align: top; font-size: 12pt">&nbsp;</TD></TR>
<TR>
    <TD STYLE="vertical-align: bottom; font-size: 12pt">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; font-size: 12pt; text-align: center">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; font-size: 12pt">&nbsp;</TD>
    <TD STYLE="vertical-align: top; font-size: 12pt">&nbsp;</TD></TR>
<TR>
    <TD STYLE="vertical-align: bottom; font-size: 12pt"><FONT STYLE="font-size: 10pt">/s/</FONT> <FONT STYLE="font-size: 10pt">Flemming
    Ornskov, M.D.</FONT></TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: top">December 13, 2017</TD></TR>
<TR STYLE="vertical-align: bottom">
    <TD STYLE="font-size: 12pt; border-top: Black 1pt solid"><FONT STYLE="font-size: 10pt">Flemming Ornskov, M.D.</FONT></TD>
    <TD STYLE="font-size: 12pt; text-align: right">&nbsp;</TD>
    <TD STYLE="font-size: 12pt"><FONT STYLE="font-size: 10pt">Chief Executive Officer and Director </FONT></TD>
    <TD STYLE="border-top: Black 1pt solid">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Date</P></TD></TR>
<TR STYLE="vertical-align: bottom">
    <TD STYLE="font-size: 12pt">&nbsp;</TD>
    <TD STYLE="font-size: 12pt; text-align: right">&nbsp;</TD>
    <TD STYLE="font-size: 12pt">&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom">
    <TD STYLE="font-size: 10pt">/s/ Jeffrey Poulton</TD>
    <TD STYLE="font-size: 12pt; text-align: right">&nbsp;</TD>
    <TD STYLE="font-size: 12pt">&nbsp;</TD>
    <TD>December 13, 2017</TD></TR>
<TR STYLE="vertical-align: bottom">
    <TD STYLE="border-top: Black 1pt solid">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Jeffrey Poulton</P></TD>
    <TD STYLE="font-size: 12pt; text-align: right">&nbsp;</TD>
    <TD STYLE="font-size: 12pt"><FONT STYLE="font-size: 10pt">Chief Financial Officer and Director</FONT></TD>
    <TD STYLE="border-top: Black 1pt solid">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Date</P></TD></TR>
<TR STYLE="vertical-align: bottom">
    <TD>&nbsp;</TD>
    <TD STYLE="font-size: 12pt; text-align: right">&nbsp;</TD>
    <TD STYLE="font-size: 12pt">&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom">
    <TD>/s/ Susan Kilsby</TD>
    <TD STYLE="font-size: 12pt; text-align: right">&nbsp;</TD>
    <TD STYLE="font-size: 12pt">&nbsp;</TD>
    <TD>December 13, 2017</TD></TR>
<TR STYLE="vertical-align: bottom">
    <TD STYLE="border-top: Black 1pt solid">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Susan Kilsby</P></TD>
    <TD STYLE="font-size: 12pt; text-align: right">&nbsp;</TD>
    <TD STYLE="font-size: 12pt"><FONT STYLE="font-size: 10pt">Chairman</FONT></TD>
    <TD STYLE="border-top: Black 1pt solid">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Date</P></TD></TR>
<TR STYLE="vertical-align: bottom">
    <TD>&nbsp;</TD>
    <TD STYLE="font-size: 12pt; text-align: right">&nbsp;</TD>
    <TD STYLE="font-size: 12pt">&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom">
    <TD>/s/ William Burns</TD>
    <TD STYLE="font-size: 12pt; text-align: right">&nbsp;</TD>
    <TD STYLE="font-size: 12pt">&nbsp;</TD>
    <TD>December 13, 2017</TD></TR>
<TR STYLE="vertical-align: bottom">
    <TD STYLE="border-top: Black 1pt solid">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">William Burns</P></TD>
    <TD STYLE="font-size: 12pt; text-align: right">&nbsp;</TD>
    <TD STYLE="font-size: 12pt"><FONT STYLE="font-size: 10pt">Senior Independent Director</FONT></TD>
    <TD STYLE="border-top: Black 1pt solid">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Date</P></TD></TR>
<TR STYLE="vertical-align: bottom">
    <TD>&nbsp;</TD>
    <TD STYLE="font-size: 12pt; text-align: right">&nbsp;</TD>
    <TD STYLE="font-size: 12pt">&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom">
    <TD>/s/ Dominic Blakemore</TD>
    <TD STYLE="font-size: 12pt; text-align: right">&nbsp;</TD>
    <TD STYLE="font-size: 12pt">&nbsp;</TD>
    <TD>December 13, 2017</TD></TR>
<TR STYLE="vertical-align: bottom">
    <TD STYLE="border-top: Black 1pt solid">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Dominic Blakemore</P></TD>
    <TD STYLE="font-size: 12pt; text-align: right">&nbsp;</TD>
    <TD STYLE="font-size: 12pt"><FONT STYLE="font-size: 10pt">Non-Executive Director</FONT></TD>
    <TD STYLE="border-top: Black 1pt solid">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Date</P></TD></TR>
<TR STYLE="vertical-align: bottom">
    <TD>&nbsp;</TD>
    <TD STYLE="font-size: 12pt; text-align: right">&nbsp;</TD>
    <TD STYLE="font-size: 12pt">&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom">
    <TD>/s/ Olivier Bohuon</TD>
    <TD STYLE="font-size: 12pt; text-align: right">&nbsp;</TD>
    <TD STYLE="font-size: 12pt">&nbsp;</TD>
    <TD>December 13, 2017</TD></TR>
<TR STYLE="vertical-align: bottom">
    <TD STYLE="border-top: Black 1pt solid">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Olivier Bohuon</P></TD>
    <TD STYLE="font-size: 12pt; text-align: right">&nbsp;</TD>
    <TD STYLE="font-size: 12pt"><FONT STYLE="font-size: 10pt">Non-Executive Director</FONT></TD>
    <TD STYLE="border-top: Black 1pt solid">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Date</P></TD></TR>
<TR STYLE="vertical-align: bottom">
    <TD>&nbsp;</TD>
    <TD STYLE="font-size: 12pt; text-align: right">&nbsp;</TD>
    <TD STYLE="font-size: 12pt">&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom">
    <TD>/s/ Ian Clark</TD>
    <TD STYLE="font-size: 12pt; text-align: right">&nbsp;</TD>
    <TD STYLE="font-size: 12pt">&nbsp;</TD>
    <TD>December 13, 2017</TD></TR>
<TR STYLE="vertical-align: bottom">
    <TD STYLE="border-top: Black 1pt solid">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Ian Clark</P></TD>
    <TD STYLE="font-size: 12pt; text-align: right">&nbsp;</TD>
    <TD STYLE="font-size: 12pt"><FONT STYLE="font-size: 10pt">Non-Executive Director</FONT></TD>
    <TD STYLE="border-top: Black 1pt solid">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Date</P></TD></TR>
<TR STYLE="vertical-align: bottom">
    <TD>&nbsp;</TD>
    <TD STYLE="font-size: 12pt; text-align: right">&nbsp;</TD>
    <TD STYLE="font-size: 12pt">&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
</TABLE>

<P STYLE="margin: 0">&nbsp;</P>

<P STYLE="margin: 0">&nbsp;</P>

<P STYLE="margin: 0"></P>

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<P STYLE="margin: 0">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
<TR STYLE="vertical-align: bottom">
    <TD STYLE="width: 31%">/s/ Gail Fosler</TD>
    <TD STYLE="font-size: 12pt; text-align: right; width: 10%">&nbsp;</TD>
    <TD STYLE="font-size: 12pt; width: 37%">&nbsp;</TD>
    <TD STYLE="width: 22%">December 13, 2017</TD></TR>
<TR STYLE="vertical-align: bottom">
    <TD STYLE="border-top: Black 1pt solid">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Gail Fosler</P></TD>
    <TD STYLE="font-size: 12pt; text-align: right">&nbsp;</TD>
    <TD STYLE="font-size: 12pt"><FONT STYLE="font-size: 10pt">Non-Executive Director</FONT></TD>
    <TD STYLE="border-top: Black 1pt solid">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Date</P></TD></TR>
<TR STYLE="vertical-align: bottom">
    <TD>&nbsp;</TD>
    <TD STYLE="font-size: 12pt; text-align: right">&nbsp;</TD>
    <TD STYLE="font-size: 12pt">&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom">
    <TD>/s/ <FONT STYLE="font-size: 10pt">Steven Gillis, Ph.D.</FONT></TD>
    <TD STYLE="font-size: 12pt; text-align: right">&nbsp;</TD>
    <TD STYLE="font-size: 12pt">&nbsp;</TD>
    <TD>December 13, 2017</TD></TR>
<TR STYLE="vertical-align: bottom">
    <TD STYLE="font-size: 12pt; border-top: Black 1pt solid"><FONT STYLE="font-size: 10pt">Steven Gillis, Ph.D.</FONT></TD>
    <TD STYLE="font-size: 12pt; text-align: right">&nbsp;</TD>
    <TD STYLE="font-size: 12pt"><FONT STYLE="font-size: 10pt">Non-Executive Director</FONT></TD>
    <TD STYLE="border-top: Black 1pt solid">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Date</P></TD></TR>
<TR STYLE="vertical-align: bottom">
    <TD STYLE="font-size: 12pt">&nbsp;</TD>
    <TD STYLE="font-size: 12pt; text-align: right">&nbsp;</TD>
    <TD STYLE="font-size: 12pt">&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom">
    <TD STYLE="font-size: 10pt">/s/ David Ginsburg, M.D.</TD>
    <TD STYLE="font-size: 12pt; text-align: right">&nbsp;</TD>
    <TD STYLE="font-size: 12pt">&nbsp;</TD>
    <TD>December 13, 2017</TD></TR>
<TR STYLE="vertical-align: bottom">
    <TD STYLE="border-top: Black 1pt solid">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">David Ginsburg, M.D.</P></TD>
    <TD STYLE="font-size: 12pt; text-align: right">&nbsp;</TD>
    <TD STYLE="font-size: 12pt"><FONT STYLE="font-size: 10pt">Non-Executive Director</FONT></TD>
    <TD STYLE="border-top: Black 1pt solid">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Date</P></TD></TR>
<TR STYLE="vertical-align: bottom">
    <TD>&nbsp;</TD>
    <TD STYLE="font-size: 12pt; text-align: right">&nbsp;</TD>
    <TD STYLE="font-size: 12pt">&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom">
    <TD>/s/ Siloo Sara Mathew</TD>
    <TD STYLE="font-size: 12pt; text-align: right">&nbsp;</TD>
    <TD STYLE="font-size: 12pt">&nbsp;</TD>
    <TD>December 13, 2017</TD></TR>
<TR STYLE="vertical-align: bottom">
    <TD STYLE="border-top: Black 1pt solid">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Siloo Sara Mathew</P></TD>
    <TD STYLE="font-size: 12pt; text-align: right">&nbsp;</TD>
    <TD STYLE="font-size: 12pt"><FONT STYLE="font-size: 10pt">Non-Executive Director</FONT></TD>
    <TD STYLE="border-top: Black 1pt solid">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Date</P></TD></TR>
<TR STYLE="vertical-align: bottom">
    <TD>&nbsp;</TD>
    <TD STYLE="font-size: 12pt; text-align: right">&nbsp;</TD>
    <TD STYLE="font-size: 12pt">&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom">
    <TD>/s/ Anne Minto</TD>
    <TD STYLE="font-size: 12pt; text-align: right">&nbsp;</TD>
    <TD STYLE="font-size: 12pt">&nbsp;</TD>
    <TD>December 13, 2017</TD></TR>
<TR STYLE="vertical-align: bottom">
    <TD STYLE="border-top: Black 1pt solid">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Anne Minto</P></TD>
    <TD STYLE="font-size: 12pt; text-align: right">&nbsp;</TD>
    <TD STYLE="font-size: 12pt"><FONT STYLE="font-size: 10pt">Non-Executive Director</FONT></TD>
    <TD STYLE="border-top: Black 1pt solid">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Date</P></TD></TR>
<TR STYLE="vertical-align: bottom">
    <TD>&nbsp;</TD>
    <TD STYLE="font-size: 12pt; text-align: right">&nbsp;</TD>
    <TD STYLE="font-size: 12pt">&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom">
    <TD>/s/ Albert Stroucken</TD>
    <TD STYLE="font-size: 12pt; text-align: right"></TD>
    <TD STYLE="font-size: 12pt">&nbsp;</TD>
    <TD>December 13, 2017</TD></TR>
<TR STYLE="vertical-align: bottom">
    <TD STYLE="border-top: Black 1pt solid">
<DIV STYLE="padding: 0in">

        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Albert Stroucken</P>
</DIV></TD>
    <TD STYLE="font-size: 12pt; text-align: right">&nbsp;</TD>
    <TD STYLE="font-size: 12pt"><FONT STYLE="font-size: 10pt">Non-Executive Director</FONT></TD>
    <TD STYLE="border-top: Black 1pt solid">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Date</P></TD></TR>
</TABLE>


<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">AUTHORIZED U.S. REPRESENTATIVE</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">/s/ William Mordan</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"></P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt; text-align: justify; text-indent: 0pt">Shire plc</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 106.35pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: left"><BR>
By: William Mordan, as the duly authorized<BR>
representative of Shire plc in the United States<BR>
<BR>
Date: December 13, 2017</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: left">&nbsp;</P>


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[{"type": "S-8", "sequence": "1", "filename": "dp84078_s8-eaip.htm", "description": "FORM S-8", "secsgml_size_bytes": 62098}]
{"company-data": {"conformed-name": "Shire plc", "cik": "0000936402", "assigned-sic": "2834", "irs-number": "000000000", "fiscal-year-end": "1231"}, "filing-values": {"form-type": "S-8", "act": "33", "file-number": "333-222044", "film-number": "171254563"}, "business-address": {"street1": "BLOCK 2, MIESIAN PLAZA", "street2": "50-58 BAGGOT STREET LOWER", "city": "DUBLIN 2", "state": "L2", "zip": "D02 HW68", "phone": "353-1-609-6000"}, "mail-address": {"street1": "BLOCK 2, MIESIAN PLAZA", "street2": "50-58 BAGGOT STREET LOWER", "city": "DUBLIN 2", "state": "L2", "zip": "D02 HW68"}, "former-company": [{"former-conformed-name": "Shire Ltd.", "date-changed": "20080523"}, {"former-conformed-name": "Shire plc", "date-changed": "20051125"}, {"former-conformed-name": "SHIRE PHARMACEUTICALS GROUP PLC", "date-changed": "19980302"}]}
As filed
with the Securities and Exchange Commission on
December 13
, 2017
Registration
No. 333-_____
SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM S-8
REGISTRATION
STATEMENT UNDER
THE SECURITIES ACT OF 1933
SHIRE PLC
(Exact Name of Registrant
as Specified in its Charter)
Jersey (Channel Islands)
98-0601486
(State or Other Jurisdiction of Incorporation or Organization)
(I.R.S. Employer
Identification No.)
Miesian Plaza
Blocks 2 and 3
50-58 Baggot Street Lower
Dublin 2, D02 Y754
Ireland
(Address of Principal Executive Offices)
The Shire Executive Annual Incentive
Plan
(Full Titles of the Plan(s))
William Mordan
General Counsel and Company Secretary
Shire PLC
Miesian Plaza
Blocks 2 and 3
50-58 Baggot Street Lower
Dublin 2, D02 Y754
Ireland
(Name and Address of Agent for Service)
+353 1 609 6000
(Telephone Number, Including Area Code, of Agent for Service)
With copies to:
John B. Meade, Esq.
Davis Polk &
        Wardwell LLP
450 Lexington Avenue
New York, NY 0017
(212) 450-4000
Kyoko Takahashi
        Lin, Esq.
Davis Polk &
        Wardwell LLP
450 Lexington Avenue
New York, NY 10017
(212) 450-4000
Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, or a smaller reporting company.
See the definitions of "large accelerated filer," "accelerated filer" and "smaller reporting company" in Rule 12b-2 of the Exchange Act.
Large accelerated filer
☒
Accelerated filer
☐
Non-accelerated filer
☐
(Do not check if a smaller reporting company)
Smaller reporting company
☐
CALCULATION
OF REGISTRATION FEE
Title of Each Class of Securities to be Registered
Amount to Be Registered (2)
Proposed Maximum Offering Price
Per Share (3)(4)
Proposed Maximum Aggregate Offering Price
(3)(4)
Amount of Registration Fee (4)
Ordinary Shares, nominal value £0.05 per Ordinary Share, to be issued under the Shire Executive Annual Incentive Plan (1)
9,400
$47.24
$444,056
$55.28
American Depository Shares, each representing three Ordinary Shares (1) ("ADSs")
3,134
-
-
-
(1)
The Ordinary Shares of Shire plc (the "Company" or the "Registrant") may
be represented by the Registrant's ADSs, evidenced by American Depositary Receipts ("ADRs"), each representing
three Ordinary Shares. Separate Registration Statements on Form F-6 were filed with the Securities and Exchange Commission (the
"Commission") on November 14, 2014 (with a Post-Effective Amendment No. 1 filed with the Commission on Form F-6 POS
on May 8, 2017) and May 4, 2016, for the registration of ADSs evidenced by ADRs issuable upon deposit of Ordinary Shares.
(2)
Pursuant to Rule 416(a) under the Securities Act of 1933, as amended (the "Securities Act"),
this Registration Statement shall also cover any additional Ordinary Shares of the Registrant that may become issuable under the
Shire Executive Annual Incentive Plan as a result of any stock split, stock dividend or similar transaction.
(3)
Estimated pursuant to Rule 457(c) and
Rule 457(h) under the Securities Act, solely for the purpose of computing the registration fee, based on the average of the high
and low prices reported for an Ordinary Share on the London Stock Exchange on December 7, 2017 (£35.47), converted from
Pounds Sterling to U.S. Dollars at the currency cross rate at the close of the NASDAQ Stock Exchange on December 12, 2017, as
reported by the Wall Street Journal (£1=U.S.$1.3318).
(4)
Rounded up to the nearest cent.
EXPLANATORY
NOTE
Shire plc, a company
organized under the laws of Jersey (Channel Islands) (the "Company" or the "Registrant"), is filing this
Registration Statement on Form S-8 with respect to up to 9,400 of its Ordinary Shares, nominal value £0.05 per share, to
be issued under the Shire Executive Annual Incentive Plan (the "EAIP").
The
Company filed a Form S-8 on March 1, 2010 (File No. 333-165137), which registered 300,000 Ordinary Shares for issuance under the
EAIP.
Pursuant to General Instruction E to Form S-8, the contents of the previous registration statements relating
to the EAIP (File No. 333-165137) are incorporated by reference herein and made a part of this Registration Statement, except as
amended hereby.
PART II
INFORMATION REQUIRED IN THE
REGISTRATION STATEMENT
ITEM 3.
INCORPORATION OF DOCUMENTS BY REFERENCE
.
The reports listed
below have been filed with or furnished to Commission by the Registrant and are incorporated herein by reference to the extent
not superseded by documents or reports subsequently filed or furnished:
(a)
The Registrant's Annual Report on Form 10-K for the fiscal year ended December 31, 2016, filed with the Commission
on February 22, 2017.
(b)
All reports filed pursuant to Section 13(a) or 15(d) of the Securities Exchange Act of 1934, as amended, (the "Exchange
Act") since December 31, 2016.
(c)
The description of the Registrant's Ordinary Shares and ADRs evidencing ADSs contained in the Registrant's Current
Report on Form 8-K, filed with the Commission on May 23, 2008, including any amendments or supplements thereto.
In addition, all documents
filed by the Registrant pursuant to Sections 13(a), 13(c), 14 and 15(d) of the Exchange Act, subsequent to the date of this Registration
Statement and prior to the filing of a post-effective amendment to this Registration Statement which indicates that all securities
offered have been sold or which deregisters all securities then remaining unsold, shall be deemed to be incorporated by reference
in this Registration Statement and to be a part hereof from the date of the filing of such documents.
Any statement contained
in a document incorporated or deemed to be incorporated by reference herein shall be deemed to be modified or superseded for purposes
of this Registration Statement to the extent that a statement contained herein, (or in any other subsequently filed document which
also is incorporated or deemed to be incorporated by reference herein), modifies or supersedes such statement. Any such statement
so modified or superseded shall not be deemed, except as so modified or superseded, to constitute a part of this Registration Statement.
ITEM 5.
INTERESTS OF NAMED EXPERTS
        AND COUNSEL.
Not applicable.
ITEM 8.
EXHIBITS.
The following exhibits are included
        or incorporated herein by reference:
4.1
Memorandum of Association as adopted by special resolution passed on April 10, 2008 and
amended by special resolution on September 24, 2008 and by further special resolution on April 28, 2016, and Articles of Association
as
amended and adopted by special resolution on April 25, 2017, incorporated by reference to Registration Statement on Form S-8 filed on December 13, 2017.
4.2
Amended and Restated Deposit Agreement, dated as of May 23, 2011, among the Company, Citibank, N.A., as depositary, and all holders and beneficial owners from time to time of ADRs issued thereunder evidencing ADSs, incorporated by reference to Registration Statement on Form F-6 filed on November 14, 2014.
5.1
Opinion of Mourant Ozannes, as to the legality of the Ordinary Shares being issued pursuant hereto.
23.1
Consent of Deloitte LLP, Independent Registered Public Accounting Firm of Shire plc.
23.2
Consent of Deloitte LLP, Independent Registered Public Accounting Firm of Shire plc.
23.3
Consent of Mourant Ozannes (included in Exhibit 5.1).
24.1
Power of Attorney (included in the signature pages hereof).
99.1
Shire Executive Annual Incentive Plan (filed herewith).
EXHIBIT
INDEX
Exhibit
Number
4.1
Memorandum of Association as adopted by special resolution passed on April 10, 2008 and amended by special resolution on September 24, 2008 and by further special resolution on April 28, 2016, and Articles of Association as amended and adopted by special resolution on April 25, 2017, incorporated by reference to Registration Statement on Form S-8 filed on December 13, 2017.
4.2
Amended and Restated Deposit Agreement, dated as of May 23, 2011, among the Company, Citibank, N.A., as depositary, and all holders and beneficial owners from time to time of ADRs issued thereunder evidencing ADSs, incorporated by reference to Registration Statement on Form F-6 filed on November 14, 2014.
5.1
Opinion of Mourant Ozannes, as to the legality of the Ordinary Shares being issued pursuant hereto.
23.1
Consent of Deloitte LLP, Independent Registered Public Accounting Firm of Shire plc.
23.2
Consent of Deloitte LLP, Independent Registered Public Accounting Firm of Shire plc.
23.3
Consent of Mourant Ozannes (included in Exhibit 5.1).
24.1
Power of Attorney (included in the signature pages hereof).
99.1
Shire Executive Annual Incentive Plan (filed herewith).
SIGNATURES
Pursuant to the
requirements of the Securities Act of 1933, as amended, the Registrant certifies that it has reasonable grounds to believe that
it meets all of the requirements for filing on Form S-8 and has duly caused this Registration Statement to be signed on its behalf
by the undersigned, thereunto duly authorized, in Lexington, Massachusetts, on the 13
th
day of December, 2017.
SHIRE PLC
By
/s/  Flemming Ornskov, M.D.
Name:
Flemming Ornskov, M.D.
Title:
Chief Executive Officer
POWER OF
ATTORNEY
KNOW ALL PERSONS
BY THESE PRESENTS, that each person whose signature appears below, constitutes and appoints each of Flemming Ornskov, M.D. and
William Mordan as his or her true and lawful attorney-in-fact and agent, upon the action of such appointee, with full power of
substitution and resubstitution, to do any and all acts and things and execute, in the name of the undersigned, any and all instruments
which each of said attorneys-in-fact and agents may deem necessary or advisable in order to enable Shire plc to comply with the
Securities Act of 1933, as amended (the "Securities Act"), and any requirements of the Securities and Exchange Commission
(the "Commission") in respect thereof, in connection with the filing with the Commission of this registration statement
on Form S-8 (this "Registration Statement") under the Securities Act, including specifically but without limitation,
power and authority to sign the name of the undersigned to such Registration Statement, and any amendments to such Registration
Statement (including post-effective amendments), which amendments may make such other changes in this Registration Statement as
such attorney-in-fact deems appropriate, and any registration statements filed by the Registrant pursuant to Rule 462(b) of the
Securities Act relating thereto, and to file the same with all exhibits thereto and other documents in connection therewith, with
the Commission, to sign any and all applications, registration statements, notices or other documents necessary or advisable to
comply with applicable state securities laws, and to file the same, together with other documents in connection therewith with
the appropriate state securities authorities, granting unto each of said attorneys-in-fact and agents full power and authority
to do and to perform each and every act and thing requisite or necessary to be done in and about the premises, as fully and to
all intents and purposes as the undersigned might or could do in person, hereby ratifying and confirming all that each of said
attorneys-in-fact and agents may lawfully do or cause to be done by virtue hereof.
Pursuant to the requirements of the Securities
Act, this Registration Statement has been signed by the following persons in the following capacities and on the date indicated
above.
Signature
Title
Date
/s/
Flemming
    Ornskov, M.D.
December 13, 2017
Flemming Ornskov, M.D.
Chief Executive Officer and Director
Date
/s/ Jeffrey Poulton
December 13, 2017
Jeffrey Poulton
Chief Financial Officer and Director
Date
/s/ Susan Kilsby
December 13, 2017
Susan Kilsby
Chairman
Date
/s/ William Burns
December 13, 2017
William Burns
Senior Independent Director
Date
/s/ Dominic Blakemore
December 13, 2017
Dominic Blakemore
Non-Executive Director
Date
/s/ Olivier Bohuon
December 13, 2017
Olivier Bohuon
Non-Executive Director
Date
/s/ Ian Clark
December 13, 2017
Ian Clark
Non-Executive Director
Date
/s/ Gail Fosler
December 13, 2017
Gail Fosler
Non-Executive Director
Date
/s/
Steven Gillis, Ph.D.
December 13, 2017
Steven Gillis, Ph.D.
Non-Executive Director
Date
/s/ David Ginsburg, M.D.
December 13, 2017
David Ginsburg, M.D.
Non-Executive Director
Date
/s/ Siloo Sara Mathew
December 13, 2017
Siloo Sara Mathew
Non-Executive Director
Date
/s/ Anne Minto
December 13, 2017
Anne Minto
Non-Executive Director
Date
/s/ Albert Stroucken
December 13, 2017
Albert Stroucken
Non-Executive Director
Date
AUTHORIZED U.S. REPRESENTATIVE
/s/ William Mordan
Shire plc
By: William Mordan, as the duly authorized
representative of Shire plc in the United States
Date: December 13, 2017