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<p style="font-family: Times New Roman; font-size: 10pt; font-variant: normal; text-align: center; margin: 0pt;"><b>As filed with the Securities and Exchange Commission on May 20, 2024 </b>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</p>

<p style="font-family:Times New Roman;font-size:10pt;font-variant:normal;text-align:right;margin:0pt 0pt 0pt 8pt;"><b>Registration No. 333-</b></p>

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<p style="font-family: Times New Roman; font-size: 12pt; font-variant: normal; text-align: center; margin: 0pt;"><b>UNITED STATES</b></p>

<p style="font-family: Times New Roman; font-size: 12pt; font-variant: normal; text-align: center; margin: 0pt;"><b>SECURITIES AND EXCHANGE COMMISSION</b></p>

<p style="font-family: Times New Roman; font-size: 10pt; font-variant: normal; text-align: center; margin: 0pt;">Washington, D.C. 20549</p>

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<p style="font-family: Times New Roman; font-size: 12pt; font-variant: normal; text-align: center; margin: 0pt;"><b>FORM S-8</b></p>

<p style="font-family: Times New Roman; font-size: 10pt; font-variant: normal; text-align: center; margin: 0pt;">REGISTRATION STATEMENT</p>

<p style="font-family: Times New Roman; font-size: 10pt; font-variant: normal; text-align: center; margin: 0pt;">UNDER</p>

<p style="font-family: Times New Roman; font-size: 10pt; font-variant: normal; text-align: center; margin: 0pt;">THE SECURITIES ACT OF 1933</p>

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<p style="font-family: Times New Roman; font-size: 12pt; font-variant: normal; text-align: center; margin: 0pt;"><b>TALPHERA, INC.</b></p>

<p style="font-family: Times New Roman; font-size: 10pt; font-variant: normal; text-align: center; margin: 0pt;">(Exact name of registrant as specified in its charter)</p>

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			<p style="font-family:Times New Roman;font-size:10pt;font-variant:normal;text-align:center;margin:0pt;"><b>Delaware</b></p>
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			<p style="font-family:Times New Roman;font-size:10pt;font-variant:normal;text-align:center;margin:0pt;"><b>41-2193603</b></p>
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			<p style="font-family:Times New Roman;font-size:10pt;font-variant:normal;text-align:center;margin:0pt;">(State or other jurisdiction of Incorporation or organization)</p>
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			<p style="font-family:Times New Roman;font-size:10pt;font-variant:normal;text-align:center;margin:0pt;">(I.R.S. Employer Identification No.)</p>
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<p style="font-family: Times New Roman; font-size: 10pt; font-variant: normal; text-align: center; margin: 0pt;"><b>1850 Gateway Drive, Suite 175</b></p>

<p style="font-family: Times New Roman; font-size: 10pt; font-variant: normal; text-align: center; margin: 0pt;"><b>San Mateo, CA 94404</b></p>

<p style="font-family: Times New Roman; font-size: 10pt; font-variant: normal; text-align: center; margin: 0pt;">(Address of principal executive offices) (Zip code)</p>

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<p style="font-family: Times New Roman; font-size: 10pt; font-variant: normal; text-align: center; margin: 0pt;"><b>Non-Plan Inducement Stock Option Grant</b></p>

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<p style="font-family: Times New Roman; font-size: 10pt; font-variant: normal; text-align: center; margin: 0pt;">(Full title of the plan)</p>

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<p style="font-family: Times New Roman; font-size: 10pt; font-variant: normal; text-align: center; margin: 0pt;"><b>Raffi Asadorian</b></p>

<p style="font-family: Times New Roman; font-size: 10pt; font-variant: normal; text-align: center; margin: 0pt;"><b>Chief Financial Officer</b></p>

<p style="font-family: Times New Roman; font-size: 10pt; font-variant: normal; text-align: center; margin: 0pt;"><b>Talphera, Inc.</b></p>

<p style="font-family: Times New Roman; font-size: 10pt; font-variant: normal; text-align: center; margin: 0pt;"><b>1850 Gateway Drive, Suite 175</b></p>

<p style="font-family: Times New Roman; font-size: 10pt; font-variant: normal; text-align: center; margin: 0pt;"><b>San Mateo, CA 94404</b></p>

<p style="font-family: Times New Roman; font-size: 10pt; font-variant: normal; text-align: center; margin: 0pt;"><b>(650) 216-3500</b></p>

<p style="font-family: Times New Roman; font-size: 10pt; font-variant: normal; text-align: center; margin: 0pt;">(Name and address of agent for service) (Telephone number, including area code, of agent for service)</p>

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<p style="font-family: Times New Roman; font-size: 10pt; font-variant: normal; text-align: center; margin: 0pt;"><b>Copy to:</b></p>

<p style="font-family: Times New Roman; font-size: 10pt; font-variant: normal; text-align: center; margin: 0pt;"><b>John T. McKenna</b></p>

<p style="font-family: Times New Roman; font-size: 10pt; font-variant: normal; text-align: center; margin: 0pt;"><b>Cooley LLP</b></p>

<p style="font-family: Times New Roman; font-size: 10pt; font-variant: normal; text-align: center; margin: 0pt;"><b>3175 Hanover Street</b></p>

<p style="font-family: Times New Roman; font-size: 10pt; font-variant: normal; text-align: center; margin: 0pt;"><b>Palo Alto, California 94304</b></p>

<p style="font-family: Times New Roman; font-size: 10pt; font-variant: normal; text-align: center; margin: 0pt;"><b>(650) 843-5000</b></p>

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<p style="font-family: Times New Roman; font-size: 10pt; font-variant: normal; text-align: justify; margin: 0pt; text-indent: 36pt;">Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, a smaller reporting company, or an emerging growth company. See the definitions of &#8220;large accelerated filer,&#8221; &#8220;accelerated filer,&#8221; &#8220;smaller reporting company,&#8221; and &#8220;emerging growth company&#8221; in Rule 12b-2 of the Exchange Act.</p>

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			<p style="font-family:Times New Roman;font-size:10pt;font-variant:normal;text-align:justify;margin:0pt 0pt 0pt 36pt;">Large accelerated filer &#9744;</p>
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			<p style="font-family:Times New Roman;font-size:10pt;font-variant:normal;text-align:justify;margin:0pt;">Accelerated filer &#9744;</p>
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			<p style="font-family:Times New Roman;font-size:10pt;font-variant:normal;text-align:justify;margin:0pt 0pt 0pt 36pt;">Non-accelerated filer &#9746;&nbsp;</p>
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			<p style="font-family:Times New Roman;font-size:10pt;font-variant:normal;text-align:justify;margin:0pt;">Smaller reporting company &#9746;</p>
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			<p style="font-family:Times New Roman;font-size:10pt;font-variant:normal;text-align:justify;margin:0pt 0pt 0pt 36pt;">Emerging growth company &#9744;</p>
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<p style="font-family:Times New Roman;font-size:10pt;font-variant:normal;text-align:justify;margin:0pt;text-indent:36pt;">If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 7(a)(2)(B) of the Securities Act.&nbsp;&nbsp;&#9744;</p>

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<p style="font-family:Times New Roman;font-size:10pt;font-variant:normal;text-align:center;margin:0pt 0pt 0pt 8pt;"><b>EXPLANATORY NOTE</b></p>

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<p style="font-family: Times New Roman; font-size: 10pt; font-variant: normal; margin: 0pt; text-align: justify;">Talphera, Inc. (the &#8220;Registrant&#8221;) is filing this registration statement on Form S-8 (the &#8220;Registration Statement&#8221;) with the Securities and Exchange Commission (the &#8220;SEC&#8221;) for the purpose of registering:</p>

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			<p style="font-family: 'Times New Roman', Times, serif;font-size: 10pt;font-variant:normal;margin:0pt;">&#8226;</p>
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			<p style="font-family: &quot;Times New Roman&quot;, Times, serif; font-size: 10pt; font-variant: normal; margin: 0pt; text-align: justify;">185,000 shares of its common stock, par value $0.001 per share (the &#8220;Common Stock&#8221;) issuable upon the exercise of an inducement stock option grant, and</p>
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			<p style="font-family:'Times New Roman';font-size:10pt;font-variant:normal;margin:0pt;">&#8226;</p>
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			<p style="font-family: Times New Roman; font-size: 10pt; font-variant: normal; margin: 0pt; text-align: justify;">32,000 shares of Common Stock issuable upon the vesting of a restricted stock unit award,</p>
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<p style="font-family:Times New Roman;font-size:10pt;font-variant:normal;text-align:justify;margin:0pt;">each to be granted to Dr. Shakil Aslam on May 20, 2024, as an inducement for accepting employment with the Registrant as Chief Development Officer (collectively, the &#8220;Inducement Awards&#8221;). The Inducement Awards will be granted outside of the Registrant&#8217;s Amended and Restated 2020 Equity Incentive Plan pursuant to the &#8220;inducement&#8221; grant exception under Nasdaq Listing Rule 5635(c)(4) and have been approved by the Registrant&#8217;s Board of Directors.</p>

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<p style="font-family:Times New Roman;font-size:10pt;font-variant:normal;text-align:center;margin:0pt;"><b>PART I</b></p>

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<p style="font-family:Times New Roman;font-size:10pt;font-variant:normal;text-align:center;margin:0pt;"><b>INFORMATION REQUIRED IN THE SECTION 10(a) PROSPECTUS </b></p>

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<p style="font-family:Times New Roman;font-size:10pt;font-variant:normal;text-align:justify;margin:0pt;">Information required by Part I of Form S-8 to be contained in the Section 10(a) prospectus is omitted from this Registration Statement in accordance with Rule 428 under the Securities Act of 1933, as amended (the &#8220;Securities Act&#8221;). The document(s) containing the information specified in Part I will be sent or given to the participant in the Inducement Awards pursuant to Rule 428(b)(1). Such document(s) are not being filed with the SEC as part of this Registration Statement or as prospectuses or prospectus supplements pursuant to Rule 424 of the Securities Act. These document(s) and the documents incorporated by reference in the Registration Statement pursuant to Item 3 of Part II of this form, taken together, constitute a prospectus that meets the requirements of Section 10(a) of the Securities Act.</p>

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<p style="font-family:Times New Roman;font-size:10pt;font-variant:normal;text-align:center;margin:0pt;"><b>PART II</b></p>

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<p style="font-family:Times New Roman;font-size:10pt;font-variant:normal;text-align:center;margin:0pt 0pt 0pt 8pt;"><b>INFORMATION REQUIRED IN THE REGISTRATION STATEMENT</b></p>

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<p style="font-family:Times New Roman;font-size:10pt;font-variant:normal;text-align:justify;margin:0pt;"><b>Item 3.</b>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<b>Incorporation of Documents by Reference.</b></p>

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<p style="font-family:Times New Roman;font-size:10pt;font-variant:normal;text-align:justify;margin:0pt;">The following documents filed by the Registrant with the SEC are incorporated by reference into this Registration Statement (other than information in such filings deemed, under SEC rules, not to have been filed with the SEC):</p>

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			<p style="font-family: Times New Roman; font-size: 10pt; font-variant: normal; margin: 0pt; text-align: justify;">the Registrant&#8217;s <a href="http://www.sec.gov/ix?doc=/Archives/edgar/data/1427925/000143774924006849/acrx20231231_10k.htm" style="-sec-extract:exhibit;">Annual Report on Form 10-K for the year ended December 31, 2023, filed with the SEC on March 6, 2024 (the &#8220;<b><i>2023 10-K</i></b>&#8221;);</a></p>
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			<p style="font-family: Times New Roman; font-size: 10pt; font-variant: normal; margin: 0pt; text-align: justify;">the Registrant&#8217;s Current Reports on Form 8-K, filed with the SEC on <a href="http://www.sec.gov/ix?doc=/Archives/edgar/data/0001427925/000143774924000938/acrx20240108_8k.htm" style="-sec-extract:exhibit;">January 9, 2024</a>&nbsp;(other than Item 7.01), <a href="http://www.sec.gov/ix?doc=/Archives/edgar/data/0001427925/000143774924001579/acrx20240117_8k.htm" style="-sec-extract:exhibit;">January 18, 2024</a>, <a href="http://www.sec.gov/ix?doc=/Archives/edgar/data/1427925/000143774924001879/acrx20240117c_8k.htm" style="-sec-extract:exhibit;">January 22, 2024</a>&nbsp;(other than Item 2.02 and Item 7.01), <a href="http://www.sec.gov/ix?doc=/Archives/edgar/data/1427925/000143774924006219/acrx20240229_8k.htm" style="-sec-extract:exhibit;">March 1, 2024</a>&nbsp;and <a href="http://www.sec.gov/ix?doc=/Archives/edgar/data/1427925/000143774924012568/acrx20240418_8k.htm" style="-sec-extract:exhibit;">April 19, 2024</a>; and</p>
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			<p style="font-family: Times New Roman; font-size: 10pt; font-variant: normal; margin: 0pt; text-align: justify;">the Registrant&#8217;s information specifically incorporated by reference in the 2023 10-K from the Registrant&#8217;s <a href="http://www.sec.gov/Archives/edgar/data/1427925/000143774924013703/acrx20240426_def14a.htm" style="-sec-extract:exhibit;">definitive proxy statement on Schedule 14A for the 2024 annual meeting of stockholders, filed with the SEC on April 29, 2024</a>;</p>
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			<p style="font-family: Times New Roman; font-size: 10pt; font-variant: normal; margin: 0pt; text-align: justify;">the Registrant&#8217;s <a href="http://www.sec.gov/ix?doc=/Archives/edgar/data/1427925/000143774924016694/acrx20240331_10q.htm" style="-sec-extract:exhibit;">Quarterly Report on Form 10-Q for the quarter ended March 31, 2024 filed with the SEC on May 14, 2024</a>; and</p>
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			<td style="vertical-align:top;">
			<p style="font-family: Times New Roman; font-size: 10pt; font-variant: normal; margin: 0pt; text-align: justify;">the description of the Registrant&#8217;s Common Stock which is contained in a registration statement on <a href="http://www.sec.gov/Archives/edgar/data/1427925/000119312511020168/d8a12b.htm" style="-sec-extract:exhibit;">Form 8-A filed with the SEC on February 1, 2011</a>&nbsp;under the Securities Exchange Act of 1934, as amended (the &#8220;Exchange Act&#8221;), including any amendment or report filed for the purpose of updating such description, including <a href="http://www.sec.gov/ix?doc=/Archives/edgar/data/1427925/000143774924006849/acrx20231231_10k.htm" style="-sec-extract:exhibit;">Exhibit 4.1</a>&nbsp;of the Registrant&#8217;s Annual Report on Form 10-K for the year ended December 31, 2020, filed with the SEC on March 15, 2021.</p>
			</td>
		</tr>

</table>

<p style="font-family:'Times New Roman';font-size:10pt;font-variant:normal;margin:0pt;">&nbsp;</p>

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<div class="PGFTR" style="text-align: center; width: 100%">
<div class="hf-row">
<div class="hf-cell PGNUM">&nbsp;</div>
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<div class="hf-cell TOCLink">&nbsp;</div>
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<p style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin: 0pt; text-align: left">&nbsp;</p>

<p style="font-family:Times New Roman;font-size:10pt;font-variant:normal;text-align:justify;margin:0pt;">All other reports and documents subsequently filed by the Registrant pursuant to Sections 13(a), 13(c), 14 and 15(d) of the Exchange Act (other than Current Reports furnished under Item 2.02 or Item 7.01 of Form 8-K and exhibits furnished on such form that relate to such items) on or after the date of this Registration Statement and prior to the filing of a post-effective amendment to this Registration Statement which indicates that all securities offered have been sold or which deregisters all securities then remaining unsold, shall be deemed to be incorporated by reference herein and to be a part of this Registration Statement from the date of the filing of such reports and documents. Any statement contained in a document incorporated or deemed to be incorporated by reference herein shall be deemed to be modified or superseded for purposes of this Registration Statement to the extent that a statement contained herein or in any subsequently filed document that also is deemed to be incorporated by reference herein modifies or supersedes such statement. Any such statement so modified or superseded shall not be deemed, except as so modified or superseded, to constitute a part of this Registration Statement.</p>

<p style="font-family:'Times New Roman';font-size:10pt;font-variant:normal;margin:0pt;">&nbsp;</p>

<p style="font-family:Times New Roman;font-size:10pt;font-variant:normal;margin:0pt;"><b>Item 4. Description of Securities</b></p>

<p style="font-family:'Times New Roman';font-size:10pt;font-variant:normal;margin:0pt;">&nbsp;</p>

<p style="font-family:Times New Roman;font-size:10pt;font-variant:normal;margin:0pt;">Not applicable.</p>

<p style="font-family:'Times New Roman';font-size:10pt;font-variant:normal;margin:0pt;">&nbsp;</p>

<p style="font-family:Times New Roman;font-size:10pt;font-variant:normal;margin:0pt;"><b>Item 5. Interests of Named Experts and Counsel</b></p>

<p style="font-family:'Times New Roman';font-size:10pt;font-variant:normal;margin:0pt;">&nbsp;</p>

<p style="font-family:Times New Roman;font-size:10pt;font-variant:normal;margin:0pt;">Not applicable.</p>

<p style="font-family:'Times New Roman';font-size:10pt;font-variant:normal;margin:0pt;">&nbsp;</p>

<p style="font-family:Times New Roman;font-size:10pt;font-variant:normal;margin:0pt;"><b>Item 6. Indemnification of Directors and Officers</b></p>

<p style="font-family:'Times New Roman';font-size:10pt;font-variant:normal;margin:0pt;">&nbsp;</p>

<p style="font-family:Times New Roman;font-size:10pt;font-variant:normal;margin:0pt;">The following summary is qualified in its entirety by reference to the complete copy of the Delaware General Corporation Law, the Registrant&#8217;s amended and restated certificate of incorporation, as amended, and the Registrant&#8217;s amended and restated bylaws. Section 145 of the Delaware General Corporation Law authorizes a court to award, or a corporation&#8217;s board of directors to grant indemnity to directors and officers under certain circumstances and subject to certain limitations. The terms of Section 145 of the Delaware General Corporation Law are sufficiently broad to permit indemnification under certain circumstances for liabilities, including reimbursement of expenses incurred, arising under the Securities Act.</p>

<p style="font-family:'Times New Roman';font-size:10pt;font-variant:normal;margin:0pt;">&nbsp;</p>

<p style="font-family:Times New Roman;font-size:10pt;font-variant:normal;margin:0pt;">As permitted by the Delaware General Corporation Law, the Registrant&#8217;s amended and restated certificate of incorporation, as amended, contains provisions that eliminate the personal liability of its directors for monetary damages for any breach of fiduciary duties as a director, except liability for the following:</p>

<p style="font-family:'Times New Roman';font-size:10pt;font-variant:normal;margin:0pt;">&nbsp;</p>

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		<tr>
			<td style="width:18pt;">&nbsp;</td>
			<td style="vertical-align:top;width:18pt;">
			<p style="font-family:'Times New Roman';font-size:10pt;font-variant:normal;margin:0pt;">&#9679;</p>
			</td>
			<td style="vertical-align:top;">
			<p style="font-family:Times New Roman;font-size:10pt;font-variant:normal;margin:0pt;">any breach of the director&#8217;s duty of loyalty to the Registrant or its stockholders;</p>
			</td>
		</tr>

</table>

<table border="0" cellpadding="0" cellspacing="0" style="width:100%;font-family:Times New Roman;font-size:10pt;">

		<tr>
			<td style="width:18pt;">&nbsp;</td>
			<td style="vertical-align:top;width:18pt;">
			<p style="font-family:'Times New Roman';font-size:10pt;font-variant:normal;margin:0pt;">&#9679;</p>
			</td>
			<td style="vertical-align:top;">
			<p style="font-family:Times New Roman;font-size:10pt;font-variant:normal;margin:0pt;">acts or omissions not in good faith or that involve intentional misconduct or a knowing violation of law;</p>
			</td>
		</tr>

</table>

<table border="0" cellpadding="0" cellspacing="0" style="width:100%;font-family:Times New Roman;font-size:10pt;">

		<tr>
			<td style="width:18pt;">&nbsp;</td>
			<td style="vertical-align:top;width:18pt;">
			<p style="font-family:'Times New Roman';font-size:10pt;font-variant:normal;margin:0pt;">&#9679;</p>
			</td>
			<td style="vertical-align:top;">
			<p style="font-family:Times New Roman;font-size:10pt;font-variant:normal;margin:0pt;">under Section 174 of the Delaware General Corporation Law (regarding unlawful dividends and stock purchases); or</p>
			</td>
		</tr>

</table>

<table border="0" cellpadding="0" cellspacing="0" style="width:100%;font-family:Times New Roman;font-size:10pt;">

		<tr>
			<td style="width:18pt;">&nbsp;</td>
			<td style="vertical-align:top;width:18pt;">
			<p style="font-family:'Times New Roman';font-size:10pt;font-variant:normal;margin:0pt;">&#9679;</p>
			</td>
			<td style="vertical-align:top;">
			<p style="font-family:Times New Roman;font-size:10pt;font-variant:normal;margin:0pt;">any transaction from which the director derived an improper personal benefit.</p>
			</td>
		</tr>

</table>

<p style="font-family:'Times New Roman';font-size:10pt;font-variant:normal;margin:0pt;">&nbsp;</p>

<p style="font-family:Times New Roman;font-size:10pt;font-variant:normal;margin:0pt;">As permitted by the Delaware General Corporation Law, the Registrant&#8217;s amended and restated bylaws provide that:</p>

<p style="font-family:'Times New Roman';font-size:10pt;font-variant:normal;margin:0pt;">&nbsp;</p>

<table border="0" cellpadding="0" cellspacing="0" style="width:100%;font-family:Times New Roman;font-size:10pt;">

		<tr>
			<td style="width:18pt;">&nbsp;</td>
			<td style="vertical-align:top;width:18pt;">
			<p style="font-family:'Times New Roman';font-size:10pt;font-variant:normal;margin:0pt;">&#9679;</p>
			</td>
			<td style="vertical-align:top;">
			<p style="font-family:Times New Roman;font-size:10pt;font-variant:normal;margin:0pt;">the Registrant is required to indemnify its directors and executive officers to the fullest extent permitted by the Delaware General Corporation Law, subject to very limited exceptions;</p>
			</td>
		</tr>

</table>

<table border="0" cellpadding="0" cellspacing="0" style="width:100%;font-family:Times New Roman;font-size:10pt;">

		<tr>
			<td style="width:18pt;">&nbsp;</td>
			<td style="vertical-align:top;width:18pt;">
			<p style="font-family:'Times New Roman';font-size:10pt;font-variant:normal;margin:0pt;">&#9679;</p>
			</td>
			<td style="vertical-align:top;">
			<p style="font-family:Times New Roman;font-size:10pt;font-variant:normal;margin:0pt;">the Registrant may indemnify its other employees and agents as set forth in the Delaware General Corporation Law;</p>
			</td>
		</tr>

</table>

<table border="0" cellpadding="0" cellspacing="0" style="width:100%;font-family:Times New Roman;font-size:10pt;">

		<tr>
			<td style="width:18pt;">&nbsp;</td>
			<td style="vertical-align:top;width:18pt;">
			<p style="font-family:'Times New Roman';font-size:10pt;font-variant:normal;margin:0pt;">&#9679;</p>
			</td>
			<td style="vertical-align:top;">
			<p style="font-family:Times New Roman;font-size:10pt;font-variant:normal;margin:0pt;">the Registrant is required to advance expenses, as incurred, to its directors and executive officers in connection with a legal proceeding to the fullest extent permitted by the Delaware General Corporation Law, subject to very limited exceptions; and</p>
			</td>
		</tr>

</table>

<table border="0" cellpadding="0" cellspacing="0" style="width:100%;font-family:Times New Roman;font-size:10pt;">

		<tr>
			<td style="width:18pt;">&nbsp;</td>
			<td style="vertical-align:top;width:18pt;">
			<p style="font-family:'Times New Roman';font-size:10pt;font-variant:normal;margin:0pt;">&#9679;</p>
			</td>
			<td style="vertical-align:top;">
			<p style="font-family:Times New Roman;font-size:10pt;font-variant:normal;margin:0pt;">the rights conferred in the Registrant&#8217;s amended and restated bylaws are not exclusive.</p>
			</td>
		</tr>

</table>

<p style="font-family:'Times New Roman';font-size:10pt;font-variant:normal;margin:0pt;">&nbsp;</p>

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<div class="PGFTR" style="text-align: center; width: 100%">
<div class="hf-row">
<div class="hf-cell PGNUM">&nbsp;</div>
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<hr style="PAGE-BREAK-AFTER: always; border: none; width: 100%; height: 2px; color: #000000; background-color: #000000">
<div class="PGHDR" style="text-align: left; width: 100%">
<div class="hf-row">
<div class="hf-cell TOCLink">&nbsp;</div>
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<p style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin: 0pt; text-align: left">&nbsp;</p>

<p style="font-family:Times New Roman;font-size:10pt;font-variant:normal;margin:0pt;">The Registrant has entered, and intends to continue to enter, into separate indemnification agreements with its directors and executive officers to provide these directors and executive officers additional contractual assurances regarding the scope of the indemnification set forth in the Registrant&#8217;s amended and restated certificate of incorporation, as amended, and amended and restated bylaws and to provide additional procedural protections. The indemnification provisions in the Registrant&#8217;s amended and restated certificate of incorporation, as amended, amended and restated bylaws and the indemnification agreements entered into or to be entered into between the Registrant and each of its directors and executive officers may be sufficiently broad to permit indemnification of the Registrant&#8217;s directors and executive officers for liabilities arising under the Securities Act. Insofar as indemnification for liabilities arising under the Securities Act may be permitted to directors, officers and controlling persons of the Registrant pursuant to the foregoing provisions, or otherwise, the Registrant has been advised that in the opinion of the Commission such indemnification is against public policy as expressed in the Securities Act and is, therefore, unenforceable.</p>

<p style="font-family:'Times New Roman';font-size:10pt;font-variant:normal;margin:0pt;">&nbsp;</p>

<p style="font-family:Times New Roman;font-size:10pt;font-variant:normal;margin:0pt;">The Registrant currently carries liability insurance for its directors and officers.</p>

<p style="font-family:'Times New Roman';font-size:10pt;font-variant:normal;margin:0pt;">&nbsp;</p>

<p style="font-family:Times New Roman;font-size:10pt;font-variant:normal;margin:0pt;"><b>Item 7. Exemption from Registration Claimed</b></p>

<p style="font-family:'Times New Roman';font-size:10pt;font-variant:normal;margin:0pt;">&nbsp;</p>

<p style="font-family:Times New Roman;font-size:10pt;font-variant:normal;margin:0pt;">Not applicable.</p>

<p style="font-family:'Times New Roman';font-size:10pt;font-variant:normal;margin:0pt;">&nbsp;</p>

<p style="font-family:'Times New Roman';font-size:10pt;font-variant:normal;margin:0pt;">&nbsp;</p>

<p style="font-family:Times New Roman;font-size:10pt;font-variant:normal;margin:0pt;"><b>Item 8.</b>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<b>Exhibits.</b></p>

<p style="font-family:'Times New Roman';font-size:10pt;font-variant:normal;margin:0pt;">&nbsp;</p>

<table border="0" cellpadding="0" cellspacing="0" style="font-family: Times New Roman; font-size: 10pt; width: 100%; margin-left: auto; margin-right: auto;">

		<tr style="font-size: 10pt;">
			<td style="vertical-align: bottom; width: 8%; font-size: 10pt;">&nbsp;</td>
			<td style="vertical-align: bottom; width: 1%; font-size: 10pt;">&nbsp;</td>
			<td style="vertical-align: bottom; width: 47%; font-size: 10pt;">&nbsp;</td>
			<td style="vertical-align: bottom; width: 1%; font-size: 10pt;">&nbsp;</td>
			<td colspan="7" style="vertical-align: bottom; width: 33%; border-bottom: 1px solid rgb(0, 0, 0); font-size: 10pt;">
			<p style="font-family:Times New Roman;font-size:10pt;font-variant:normal;text-align:center;margin:0pt;"><b>Incorporation by Reference</b></p>
			</td>
		</tr>
		<tr style="font-size: 10pt;">
			<td style="vertical-align: bottom; width: 8%; font-size: 10pt; border-bottom: 1px solid rgb(0, 0, 0);">
			<p style="font-family:Times New Roman;font-size:10pt;font-variant:normal;text-align:center;margin:0pt;"><b>Exhibit </b></p>

			<p style="font-family:Times New Roman;font-size:10pt;font-variant:normal;text-align:center;margin:0pt;"><b>Number</b></p>
			</td>
			<td style="vertical-align: bottom; width: 1%; font-size: 10pt;">&nbsp;</td>
			<td style="vertical-align: bottom; width: 47%; font-size: 10pt; border-bottom: 1px solid rgb(0, 0, 0);">
			<p style="font-family:Times New Roman;font-size:10pt;font-variant:normal;text-align:center;margin:0pt;"><b>Exhibit Description</b></p>
			</td>
			<td style="vertical-align: bottom; width: 1%; font-size: 10pt;">&nbsp;</td>
			<td style="vertical-align: bottom; width: 9%; font-size: 10pt; border-bottom: 1px solid rgb(0, 0, 0);">
			<p style="font-family:Times New Roman;font-size:10pt;font-variant:normal;text-align:center;margin:0pt;"><b>Form</b></p>
			</td>
			<td style="vertical-align: bottom; width: 1%; font-size: 10pt;">&nbsp;</td>
			<td style="vertical-align: bottom; width: 13%; font-size: 10pt; border-bottom: 1px solid rgb(0, 0, 0);">
			<p style="font-family:Times New Roman;font-size:10pt;font-variant:normal;text-align:center;margin:0pt;"><b>SEC File No.</b></p>
			</td>
			<td style="vertical-align: bottom; width: 1%; font-size: 10pt;">&nbsp;</td>
			<td style="vertical-align: bottom; width: 8%; font-size: 10pt; border-bottom: 1px solid rgb(0, 0, 0);">
			<p style="font-family:Times New Roman;font-size:10pt;font-variant:normal;text-align:center;margin:0pt;"><b>Exhibit</b></p>
			</td>
			<td style="vertical-align: bottom; width: 1%; font-size: 10pt;">&nbsp;</td>
			<td style="vertical-align: bottom; width: 10%; font-size: 10pt; border-bottom: 1px solid rgb(0, 0, 0);">
			<p style="font-family:Times New Roman;font-size:10pt;font-variant:normal;text-align:center;margin:0pt;"><b>Filing Date</b></p>
			</td>
		</tr>
		<tr style="font-size: 10pt;">
			<td style="vertical-align: top; width: 8%; font-size: 10pt;">
			<p style="font-family:Times New Roman;font-size:10pt;font-variant:normal;text-align:center;margin:0pt;">3.1</p>
			</td>
			<td style="vertical-align: top; width: 1%; font-size: 10pt;">&nbsp;</td>
			<td style="vertical-align: top; width: 47%; font-size: 10pt;">
			<p style="font-family:Times New Roman;font-size:10pt;font-variant:normal;margin:0pt;"><a href="http://www.sec.gov/Archives/edgar/data/1427925/000119312511040233/dex31.htm" style="-sec-extract:exhibit;">Amended and Restated Certificate of Incorporation of the Registrant.</a></p>
			</td>
			<td style="vertical-align: top; width: 1%; font-size: 10pt;">&nbsp;</td>
			<td style="vertical-align: top; width: 9%; font-size: 10pt;">
			<p style="font-family:Times New Roman;font-size:10pt;font-variant:normal;text-align:center;margin:0pt;">8-K</p>
			</td>
			<td style="vertical-align: top; width: 1%; font-size: 10pt;">&nbsp;</td>
			<td style="vertical-align: top; width: 13%; font-size: 10pt;">
			<p style="font-family:Times New Roman;font-size:10pt;font-variant:normal;text-align:center;margin:0pt;">001-35068</p>
			</td>
			<td style="vertical-align: top; width: 1%; font-size: 10pt;">&nbsp;</td>
			<td style="vertical-align: top; width: 8%; font-size: 10pt;">
			<p style="font-family:Times New Roman;font-size:10pt;font-variant:normal;text-align:center;margin:0pt;">3.1</p>
			</td>
			<td style="vertical-align: top; width: 1%; font-size: 10pt;">&nbsp;</td>
			<td style="vertical-align: top; width: 10%; font-size: 10pt;">
			<p style="font-family:Times New Roman;font-size:10pt;font-variant:normal;text-align:center;margin:0pt;">2/18/2011</p>
			</td>
		</tr>
		<tr style="font-size: 10pt;">
			<td style="vertical-align: top; width: 8%; font-size: 10pt;">
			<p style="font-family:Times New Roman;font-size:10pt;font-variant:normal;text-align:center;margin:0pt;">3.2</p>
			</td>
			<td style="vertical-align: top; width: 1%; font-size: 10pt;">&nbsp;</td>
			<td style="vertical-align: top; width: 47%; font-size: 10pt;">
			<p style="font-family:Times New Roman;font-size:10pt;font-variant:normal;margin:0pt;"><a href="http://www.sec.gov/Archives/edgar/data/1427925/000143774924000938/ex_613231.htm" style="-sec-extract:exhibit;">Certificate of Amendment of Amended and Restated Certificate of Incorporation of the Registrant.</a></p>
			</td>
			<td style="vertical-align: top; width: 1%; font-size: 10pt;">&nbsp;</td>
			<td style="vertical-align: top; width: 9%; font-size: 10pt;">
			<p style="font-family:Times New Roman;font-size:10pt;font-variant:normal;text-align:center;margin:0pt;">8-K</p>
			</td>
			<td style="vertical-align: top; width: 1%; font-size: 10pt;">&nbsp;</td>
			<td style="vertical-align: top; width: 13%; font-size: 10pt;">
			<p style="font-family:Times New Roman;font-size:10pt;font-variant:normal;text-align:center;margin:0pt;">001-35068</p>
			</td>
			<td style="vertical-align: top; width: 1%; font-size: 10pt;">&nbsp;</td>
			<td style="vertical-align: top; width: 8%; font-size: 10pt;">
			<p style="font-family:Times New Roman;font-size:10pt;font-variant:normal;text-align:center;margin:0pt;">3.1</p>
			</td>
			<td style="vertical-align: top; width: 1%; font-size: 10pt;">&nbsp;</td>
			<td style="vertical-align: top; width: 10%; font-size: 10pt;">
			<p style="font-family:Times New Roman;font-size:10pt;font-variant:normal;text-align:center;margin:0pt;">1/9/2024</p>
			</td>
		</tr>
		<tr style="font-size: 10pt;">
			<td style="vertical-align: top; width: 8%; font-size: 10pt;">
			<p style="font-family:Times New Roman;font-size:10pt;font-variant:normal;text-align:center;margin:0pt;">3.3</p>
			</td>
			<td style="vertical-align: top; width: 1%; font-size: 10pt;">&nbsp;</td>
			<td style="vertical-align: top; width: 47%; font-size: 10pt;">
			<p style="font-family:Times New Roman;font-size:10pt;font-variant:normal;margin:0pt;"><a href="http://www.sec.gov/Archives/edgar/data/1427925/000143774919012706/ex_148566.htm" style="-sec-extract:exhibit;">Certificate of Amendment of Amended and Restated Certificate of Incorporation of the Registrant.</a></p>
			</td>
			<td style="vertical-align: top; width: 1%; font-size: 10pt;">&nbsp;</td>
			<td style="vertical-align: top; width: 9%; font-size: 10pt;">
			<p style="font-family:Times New Roman;font-size:10pt;font-variant:normal;text-align:center;margin:0pt;">8-K</p>
			</td>
			<td style="vertical-align: top; width: 1%; font-size: 10pt;">&nbsp;</td>
			<td style="vertical-align: top; width: 13%; font-size: 10pt;">
			<p style="font-family:Times New Roman;font-size:10pt;font-variant:normal;text-align:center;margin:0pt;">001-35068</p>
			</td>
			<td style="vertical-align: top; width: 1%; font-size: 10pt;">&nbsp;</td>
			<td style="vertical-align: top; width: 8%; font-size: 10pt;">
			<p style="font-family:Times New Roman;font-size:10pt;font-variant:normal;text-align:center;margin:0pt;">3.1</p>
			</td>
			<td style="vertical-align: top; width: 1%; font-size: 10pt;">&nbsp;</td>
			<td style="vertical-align: top; width: 10%; font-size: 10pt;">
			<p style="font-family:Times New Roman;font-size:10pt;font-variant:normal;text-align:center;margin:0pt;">6/25/2019</p>
			</td>
		</tr>
		<tr style="font-size: 10pt;">
			<td style="vertical-align: top; width: 8%; font-size: 10pt;">
			<p style="font-family:Times New Roman;font-size:10pt;font-variant:normal;text-align:center;margin:0pt;">3.4</p>
			</td>
			<td style="vertical-align: top; width: 1%; font-size: 10pt;">&nbsp;</td>
			<td style="vertical-align: top; width: 47%; font-size: 10pt;">
			<p style="font-family:Times New Roman;font-size:10pt;font-variant:normal;margin:0pt;"><a href="http://www.sec.gov/Archives/edgar/data/1427925/000143774922024708/ex_436724.htm" style="-sec-extract:exhibit;">Certificate of Amendment of Amended and Restated Certificate of Incorporation of the Registrant.</a></p>
			</td>
			<td style="vertical-align: top; width: 1%; font-size: 10pt;">&nbsp;</td>
			<td style="vertical-align: top; width: 9%; font-size: 10pt;">
			<p style="font-family:Times New Roman;font-size:10pt;font-variant:normal;text-align:center;margin:0pt;">8-K</p>
			</td>
			<td style="vertical-align: top; width: 1%; font-size: 10pt;">&nbsp;</td>
			<td style="vertical-align: top; width: 13%; font-size: 10pt;">
			<p style="font-family:Times New Roman;font-size:10pt;font-variant:normal;text-align:center;margin:0pt;">001-35068</p>
			</td>
			<td style="vertical-align: top; width: 1%; font-size: 10pt;">&nbsp;</td>
			<td style="vertical-align: top; width: 8%; font-size: 10pt;">
			<p style="font-family:Times New Roman;font-size:10pt;font-variant:normal;text-align:center;margin:0pt;">3.1</p>
			</td>
			<td style="vertical-align: top; width: 1%; font-size: 10pt;">&nbsp;</td>
			<td style="vertical-align: top; width: 10%; font-size: 10pt;">
			<p style="font-family:Times New Roman;font-size:10pt;font-variant:normal;text-align:center;margin:0pt;">10/25/2022</p>
			</td>
		</tr>
		<tr style="font-size: 10pt;">
			<td style="vertical-align: top; width: 8%; font-size: 10pt;">
			<p style="font-family:Times New Roman;font-size:10pt;font-variant:normal;text-align:center;margin:0pt;">3.5</p>
			</td>
			<td style="vertical-align: top; width: 1%; font-size: 10pt;">&nbsp;</td>
			<td style="vertical-align: top; width: 47%; font-size: 10pt;">
			<p style="font-family:Times New Roman;font-size:10pt;font-variant:normal;margin:0pt;"><a href="http://www.sec.gov/Archives/edgar/data/1427925/000143774924000938/ex_613232.htm" style="-sec-extract:exhibit;">Amended and Restated Bylaws of the Registrant.</a></p>
			</td>
			<td style="vertical-align: top; width: 1%; font-size: 10pt;">&nbsp;</td>
			<td style="vertical-align: top; width: 9%; font-size: 10pt;">
			<p style="font-family:Times New Roman;font-size:10pt;font-variant:normal;text-align:center;margin:0pt;">8-K</p>
			</td>
			<td style="vertical-align: top; width: 1%; font-size: 10pt;">&nbsp;</td>
			<td style="vertical-align: top; width: 13%; font-size: 10pt;">
			<p style="font-family:Times New Roman;font-size:10pt;font-variant:normal;text-align:center;margin:0pt;">001-35068</p>
			</td>
			<td style="vertical-align: top; width: 1%; font-size: 10pt;">&nbsp;</td>
			<td style="vertical-align: top; width: 8%; font-size: 10pt;">
			<p style="font-family:Times New Roman;font-size:10pt;font-variant:normal;text-align:center;margin:0pt;">3.2</p>
			</td>
			<td style="vertical-align: top; width: 1%; font-size: 10pt;">&nbsp;</td>
			<td style="vertical-align: top; width: 10%; font-size: 10pt;">
			<p style="font-family:Times New Roman;font-size:10pt;font-variant:normal;text-align:center;margin:0pt;">1/9/2024</p>
			</td>
		</tr>
		<tr style="font-size: 10pt;">
			<td style="vertical-align: top; width: 8%; font-size: 10pt;">
			<p style="font-family:Times New Roman;font-size:10pt;font-variant:normal;text-align:center;margin:0pt;">4.1</p>
			</td>
			<td style="vertical-align: top; width: 1%; font-size: 10pt;">&nbsp;</td>
			<td style="vertical-align: top; width: 47%; font-size: 10pt;">
			<p style="font-family:Times New Roman;font-size:10pt;font-variant:normal;margin:0pt;">Reference is made to Exhibits 3.1 through 3.4.</p>
			</td>
			<td style="vertical-align: top; width: 1%; font-size: 10pt;">&nbsp;</td>
			<td style="vertical-align: top; width: 9%; font-size: 10pt;">&nbsp;</td>
			<td style="vertical-align: top; width: 1%; font-size: 10pt;">&nbsp;</td>
			<td style="vertical-align: top; width: 13%; font-size: 10pt;">&nbsp;</td>
			<td style="vertical-align: top; width: 1%; font-size: 10pt;">&nbsp;</td>
			<td style="vertical-align: top; width: 8%; font-size: 10pt;">&nbsp;</td>
			<td style="vertical-align: top; width: 1%; font-size: 10pt;">&nbsp;</td>
			<td style="vertical-align: top; width: 10%; font-size: 10pt;">&nbsp;</td>
		</tr>
		<tr style="font-size: 10pt;">
			<td style="vertical-align: top; width: 8%; font-size: 10pt;">
			<p style="font-family:Times New Roman;font-size:10pt;font-variant:normal;text-align:center;margin:0pt;">4.2</p>
			</td>
			<td style="vertical-align: top; width: 1%; font-size: 10pt;">&nbsp;</td>
			<td style="vertical-align: top; width: 47%; font-size: 10pt;">
			<p style="font-family:Times New Roman;font-size:10pt;font-variant:normal;margin:0pt;"><a href="http://www.sec.gov/Archives/edgar/data/1427925/000119312511019097/dex42.htm" style="-sec-extract:exhibit;">Specimen Common Stock Certificate of the Registrant.</a></p>
			</td>
			<td style="vertical-align: top; width: 1%; font-size: 10pt;">&nbsp;</td>
			<td style="vertical-align: top; width: 9%; font-size: 10pt;">
			<p style="font-family:Times New Roman;font-size:10pt;font-variant:normal;text-align:center;margin:0pt;">S-1/A</p>
			</td>
			<td style="vertical-align: top; width: 1%; font-size: 10pt;">&nbsp;</td>
			<td style="vertical-align: top; width: 13%; font-size: 10pt;">
			<p style="font-family:Times New Roman;font-size:10pt;font-variant:normal;text-align:center;margin:0pt;">333-170594</p>
			</td>
			<td style="vertical-align: top; width: 1%; font-size: 10pt;">&nbsp;</td>
			<td style="vertical-align: top; width: 8%; font-size: 10pt;">
			<p style="font-family:Times New Roman;font-size:10pt;font-variant:normal;text-align:center;margin:0pt;">4.2</p>
			</td>
			<td style="vertical-align: top; width: 1%; font-size: 10pt;">&nbsp;</td>
			<td style="vertical-align: top; width: 10%; font-size: 10pt;">
			<p style="font-family:Times New Roman;font-size:10pt;font-variant:normal;text-align:center;margin:0pt;">1/31/2011</p>
			</td>
		</tr>
		<tr style="font-size: 10pt;">
			<td style="vertical-align: top; width: 8%; font-size: 10pt;">
			<p style="font-family:Times New Roman;font-size:10pt;font-variant:normal;text-align:center;margin:0pt;">5.1</p>
			</td>
			<td style="vertical-align: top; width: 1%; font-size: 10pt;">&nbsp;</td>
			<td style="vertical-align: top; width: 47%; font-size: 10pt;">
			<p style="font-family:Times New Roman;font-size:10pt;font-variant:normal;margin:0pt;"><a href="ex_676580.htm" style="-sec-extract:exhibit;">Opinion of Cooley LLP.</a></p>
			</td>
			<td style="vertical-align: top; width: 1%; font-size: 10pt;">&nbsp;</td>
			<td style="vertical-align: top; width: 9%; font-size: 10pt;">&nbsp;</td>
			<td style="vertical-align: top; width: 1%; font-size: 10pt;">&nbsp;</td>
			<td style="vertical-align: top; width: 13%; font-size: 10pt;">&nbsp;</td>
			<td style="vertical-align: top; width: 1%; font-size: 10pt;">&nbsp;</td>
			<td style="vertical-align: top; width: 8%; font-size: 10pt;">&nbsp;</td>
			<td style="vertical-align: top; width: 1%; font-size: 10pt;">&nbsp;</td>
			<td style="vertical-align: top; width: 10%; font-size: 10pt;">&nbsp;</td>
		</tr>
		<tr style="font-size: 10pt;">
			<td style="vertical-align: top; width: 8%; font-size: 10pt;">
			<p style="font-family:Times New Roman;font-size:10pt;font-variant:normal;text-align:center;margin:0pt;">23.1</p>
			</td>
			<td style="vertical-align: top; width: 1%; font-size: 10pt;">&nbsp;</td>
			<td style="vertical-align: top; width: 47%; font-size: 10pt;">
			<p style="font-family:Times New Roman;font-size:10pt;font-variant:normal;margin:0pt;"><a href="ex_676581.htm" style="-sec-extract:exhibit;">Consent of BPM LLP, Independent Registered Public Accounting Firm.</a></p>
			</td>
			<td style="vertical-align: top; width: 1%; font-size: 10pt;">&nbsp;</td>
			<td style="vertical-align: top; width: 9%; font-size: 10pt;">&nbsp;</td>
			<td style="vertical-align: top; width: 1%; font-size: 10pt;">&nbsp;</td>
			<td style="vertical-align: top; width: 13%; font-size: 10pt;">&nbsp;</td>
			<td style="vertical-align: top; width: 1%; font-size: 10pt;">&nbsp;</td>
			<td style="vertical-align: top; width: 8%; font-size: 10pt;">&nbsp;</td>
			<td style="vertical-align: top; width: 1%; font-size: 10pt;">&nbsp;</td>
			<td style="vertical-align: top; width: 10%; font-size: 10pt;">&nbsp;</td>
		</tr>
		<tr style="font-size: 10pt;">
			<td style="vertical-align: top; width: 8%; font-size: 10pt;">
			<p style="font-family:Times New Roman;font-size:10pt;font-variant:normal;text-align:center;margin:0pt;">23.2</p>
			</td>
			<td style="vertical-align: top; width: 1%; font-size: 10pt;">&nbsp;</td>
			<td style="vertical-align: top; width: 47%; font-size: 10pt;">
			<p style="font-family:Times New Roman;font-size:10pt;font-variant:normal;margin:0pt;"><a href="ex_676741.htm" style="-sec-extract:exhibit;">Consent of Withum Smith &amp; Brown LLP, Independent Registered Public Accounting Firm.</a></p>
			</td>
			<td style="vertical-align: top; width: 1%; font-size: 10pt;">&nbsp;</td>
			<td style="vertical-align: top; width: 9%; font-size: 10pt;">&nbsp;</td>
			<td style="vertical-align: top; width: 1%; font-size: 10pt;">&nbsp;</td>
			<td style="vertical-align: top; width: 13%; font-size: 10pt;">&nbsp;</td>
			<td style="vertical-align: top; width: 1%; font-size: 10pt;">&nbsp;</td>
			<td style="vertical-align: top; width: 8%; font-size: 10pt;">&nbsp;</td>
			<td style="vertical-align: top; width: 1%; font-size: 10pt;">&nbsp;</td>
			<td style="vertical-align: top; width: 10%; font-size: 10pt;">&nbsp;</td>
		</tr>
		<tr style="font-size: 10pt;">
			<td style="vertical-align: top; width: 8%; font-size: 10pt;">
			<p style="font-family:Times New Roman;font-size:10pt;font-variant:normal;text-align:center;margin:0pt;">23.3</p>
			</td>
			<td style="vertical-align: top; width: 1%; font-size: 10pt;">&nbsp;</td>
			<td style="vertical-align: top; width: 47%; font-size: 10pt;">
			<p style="font-family:Times New Roman;font-size:10pt;font-variant:normal;margin:0pt;"><a href="ex_676580.htm" style="-sec-extract:exhibit;">Consent of Cooley LLP (included in Exhibit 5.1).</a></p>
			</td>
			<td style="vertical-align: top; width: 1%; font-size: 10pt;">&nbsp;</td>
			<td style="vertical-align: top; width: 9%; font-size: 10pt;">&nbsp;</td>
			<td style="vertical-align: top; width: 1%; font-size: 10pt;">&nbsp;</td>
			<td style="vertical-align: top; width: 13%; font-size: 10pt;">&nbsp;</td>
			<td style="vertical-align: top; width: 1%; font-size: 10pt;">&nbsp;</td>
			<td style="vertical-align: top; width: 8%; font-size: 10pt;">&nbsp;</td>
			<td style="vertical-align: top; width: 1%; font-size: 10pt;">&nbsp;</td>
			<td style="vertical-align: top; width: 10%; font-size: 10pt;">&nbsp;</td>
		</tr>
		<tr style="font-size: 10pt;">
			<td style="vertical-align: top; width: 8%; font-size: 10pt;">
			<p style="font-family:Times New Roman;font-size:10pt;font-variant:normal;text-align:center;margin:0pt;">24.1</p>
			</td>
			<td style="vertical-align: top; width: 1%; font-size: 10pt;">&nbsp;</td>
			<td style="vertical-align: top; width: 47%; font-size: 10pt;">
			<p style="font-family:Times New Roman;font-size:10pt;font-variant:normal;margin:0pt;"><a href="#attorney" style="-sec-extract:exhibit;">Power of Attorney (included on the signature page of this Form S-8).</a></p>
			</td>
			<td style="vertical-align: top; width: 1%; font-size: 10pt;">&nbsp;</td>
			<td style="vertical-align: top; width: 9%; font-size: 10pt;">&nbsp;</td>
			<td style="vertical-align: top; width: 1%; font-size: 10pt;">&nbsp;</td>
			<td style="vertical-align: top; width: 13%; font-size: 10pt;">&nbsp;</td>
			<td style="vertical-align: top; width: 1%; font-size: 10pt;">&nbsp;</td>
			<td style="vertical-align: top; width: 8%; font-size: 10pt;">&nbsp;</td>
			<td style="vertical-align: top; width: 1%; font-size: 10pt;">&nbsp;</td>
			<td style="vertical-align: top; width: 10%; font-size: 10pt;">&nbsp;</td>
		</tr>
		<tr style="font-size: 10pt;">
			<td style="vertical-align: top; width: 8%; font-size: 10pt;">
			<p style="font-family:Times New Roman;font-size:10pt;font-variant:normal;text-align:center;margin:0pt;">99.1+</p>
			</td>
			<td style="vertical-align: top; width: 1%; font-size: 10pt;">&nbsp;</td>
			<td style="vertical-align: top; width: 47%; font-size: 10pt;">
			<p style="font-family:Times New Roman;font-size:10pt;font-variant:normal;margin:0pt;"><a href="http://www.sec.gov/ix?doc=/Archives/edgar/data/1427925/000143774923027971/acrx20231010_8k.htm" style="-sec-extract:exhibit;">Amended and Restated 2020 Equity Incentive Plan.</a></p>
			</td>
			<td style="vertical-align: top; width: 1%; font-size: 10pt;">&nbsp;</td>
			<td style="vertical-align: top; width: 9%; font-size: 10pt;">
			<p style="font-family:Times New Roman;font-size:10pt;font-variant:normal;text-align:center;margin:0pt;">8-K</p>
			</td>
			<td style="vertical-align: top; width: 1%; font-size: 10pt;">&nbsp;</td>
			<td style="vertical-align: top; width: 13%; font-size: 10pt;">
			<p style="font-family:Times New Roman;font-size:10pt;font-variant:normal;text-align:center;margin:0pt;">001-35068</p>
			</td>
			<td style="vertical-align: top; width: 1%; font-size: 10pt;">&nbsp;</td>
			<td style="vertical-align: top; width: 8%; font-size: 10pt;">
			<p style="font-family:Times New Roman;font-size:10pt;font-variant:normal;text-align:center;margin:0pt;">10.1</p>
			</td>
			<td style="vertical-align: top; width: 1%; font-size: 10pt;">&nbsp;</td>
			<td style="vertical-align: top; width: 10%; font-size: 10pt;">
			<p style="font-family:Times New Roman;font-size:10pt;font-variant:normal;text-align:center;margin:0pt;">10/10/2023</p>
			</td>
		</tr>
		<tr style="font-size: 10pt;">
			<td style="vertical-align: top; width: 8%; font-size: 10pt;">
			<p style="font-family:Times New Roman;font-size:10pt;font-variant:normal;text-align:center;margin:0pt;">99.2*+</p>
			</td>
			<td style="vertical-align: top; width: 1%; font-size: 10pt;">&nbsp;</td>
			<td style="vertical-align: top; width: 47%; font-size: 10pt;">
			<p style="font-family:Times New Roman;font-size:10pt;font-variant:normal;margin:0pt;"><a href="ex_676582.htm" style="-sec-extract:exhibit;">Inducement Stock Option Grant and Award Agreement by and between Talphera, Inc. and Dr. Shakil Aslam.</a></p>
			</td>
			<td style="vertical-align: top; width: 1%; font-size: 10pt;">&nbsp;</td>
			<td style="vertical-align: top; width: 9%; font-size: 10pt;">&nbsp;</td>
			<td style="vertical-align: top; width: 1%; font-size: 10pt;">&nbsp;</td>
			<td style="vertical-align: top; width: 13%; font-size: 10pt;">&nbsp;</td>
			<td style="vertical-align: top; width: 1%; font-size: 10pt;">&nbsp;</td>
			<td style="vertical-align: top; width: 8%; font-size: 10pt;">&nbsp;</td>
			<td style="vertical-align: top; width: 1%; font-size: 10pt;">&nbsp;</td>
			<td style="vertical-align: top; width: 10%; font-size: 10pt;">&nbsp;</td>
		</tr>
		<tr style="font-size: 10pt;">
			<td style="vertical-align: top; width: 8%; font-size: 10pt;">
			<p style="font-family:Times New Roman;font-size:10pt;font-variant:normal;text-align:center;margin:0pt;">99.3*+</p>
			</td>
			<td style="vertical-align: top; width: 1%; font-size: 10pt;">&nbsp;</td>
			<td style="vertical-align: top; width: 47%; font-size: 10pt;">
			<p style="font-family:Times New Roman;font-size:10pt;font-variant:normal;margin:0pt;"><a href="ex_676583.htm" style="-sec-extract:exhibit;">Inducement Restricted Stock Unit Grant Notice and Award Agreement by and between Talphera, Inc. and Dr. Shakil Aslam.</a></p>
			</td>
			<td style="vertical-align: top; width: 1%; font-size: 10pt;">&nbsp;</td>
			<td style="vertical-align: top; width: 9%; font-size: 10pt;">&nbsp;</td>
			<td style="vertical-align: top; width: 1%; font-size: 10pt;">&nbsp;</td>
			<td style="vertical-align: top; width: 13%; font-size: 10pt;">&nbsp;</td>
			<td style="vertical-align: top; width: 1%; font-size: 10pt;">&nbsp;</td>
			<td style="vertical-align: top; width: 8%; font-size: 10pt;">&nbsp;</td>
			<td style="vertical-align: top; width: 1%; font-size: 10pt;">&nbsp;</td>
			<td style="vertical-align: top; width: 10%; font-size: 10pt;">&nbsp;</td>
		</tr>
		<tr style="font-size: 10pt;">
			<td style="vertical-align: top; width: 8%; font-size: 10pt;">
			<p style="font-family:Times New Roman;font-size:10pt;font-variant:normal;text-align:center;margin:0pt;">107</p>
			</td>
			<td style="vertical-align: top; width: 1%; font-size: 10pt;">&nbsp;</td>
			<td style="vertical-align: top; width: 47%; font-size: 10pt;">
			<p style="font-family:Times New Roman;font-size:10pt;font-variant:normal;margin:0pt;"><a href="ex_676584.htm" style="-sec-extract:exhibit;">Filing Fee Table</a></p>
			</td>
			<td style="vertical-align: top; width: 1%; font-size: 10pt;">&nbsp;</td>
			<td style="vertical-align: top; width: 9%; font-size: 10pt;">&nbsp;</td>
			<td style="vertical-align: top; width: 1%; font-size: 10pt;">&nbsp;</td>
			<td style="vertical-align: top; width: 13%; font-size: 10pt;">&nbsp;</td>
			<td style="vertical-align: top; width: 1%; font-size: 10pt;">&nbsp;</td>
			<td style="vertical-align: top; width: 8%; font-size: 10pt;">&nbsp;</td>
			<td style="vertical-align: top; width: 1%; font-size: 10pt;">&nbsp;</td>
			<td style="vertical-align: top; width: 10%; font-size: 10pt;">&nbsp;</td>
		</tr>

</table>

<p style="font-family:'Times New Roman';font-size:10pt;font-variant:normal;margin:0pt;">&nbsp;</p>

<hr style="text-align: left; height: 1px; color: #000000; background-color: #000000; width: 10%; border: none; margin: 3pt auto 3pt 0">
<p style="font-family:'Times New Roman';font-size:10pt;font-variant:normal;margin:0pt;">&nbsp;</p>

<table border="0" cellpadding="0" cellspacing="0" style="width: 100%; text-indent: 0px;">

		<tr style="vertical-align: top;">
			<td style="width: 36pt;">
			<p style="margin: 0pt; text-align: left; font-family: &quot;Times New Roman&quot;, Times, serif; font-size: 10pt;">+</p>
			</td>
			<td style="width: auto;">
			<p style="margin: 0pt; text-align: left; font-family: &quot;Times New Roman&quot;, Times, serif; font-size: 10pt;">Indicates management contract or compensatory plan.</p>
			</td>
		</tr>

</table>

<table border="0" cellpadding="0" cellspacing="0" style="width: 100%; text-indent: 0px;">

		<tr style="vertical-align: top;">
			<td style="width: 36pt;">
			<p style="margin: 0pt; text-align: left; font-family: &quot;Times New Roman&quot;, Times, serif; font-size: 10pt;">*</p>
			</td>
			<td style="width: auto;">
			<p style="margin: 0pt; text-align: left; font-family: &quot;Times New Roman&quot;, Times, serif; font-size: 10pt;">Filed herewith</p>
			</td>
		</tr>

</table>

<p style="font-family:Times New Roman;font-size:10pt;font-variant:normal;margin:0pt 0pt 0pt 36pt;text-indent:-36pt;">&nbsp;</p>

<div class="PGBK" style="width: 100%; margin-left: 0pt; margin-right: 0pt">
<div class="PGNUM" style="text-align: center; width: 100%">&nbsp;</div>

<hr style="PAGE-BREAK-AFTER: always; border: none; width: 100%; height: 2px; color: #000000; background-color: #000000">
<div class="PGHDR" style="text-align: left; width: 100%">&nbsp;</div>
</div>

<p style="font-family:'Times New Roman';font-size:10pt;font-variant:normal;margin:0pt;">&nbsp;</p>

<p style="font-family:Times New Roman;font-size:10pt;font-variant:normal;margin:0pt;"><b>Item 9. Undertakings</b></p>

<p style="font-family:'Times New Roman';font-size:10pt;font-variant:normal;margin:0pt;">&nbsp;</p>

<p style="font-family:Times New Roman;font-size:10pt;font-variant:normal;text-align:justify;margin:0pt;">1. The undersigned registrant hereby undertakes:</p>

<p style="font-family:'Times New Roman';font-size:10pt;font-variant:normal;margin:0pt;">&nbsp;</p>

<p style="font-family:Times New Roman;font-size:10pt;font-variant:normal;text-align:justify;margin:0pt;text-indent:18pt;">(a) To file, during any period in which offers or sales are being made, a post-effective amendment to this registration statement:</p>

<p style="font-family:'Times New Roman';font-size:10pt;font-variant:normal;margin:0pt;">&nbsp;</p>

<p style="font-family:Times New Roman;font-size:10pt;font-variant:normal;text-align:justify;margin:0pt;text-indent:50pt;">(i) To include any prospectus required by Section 10(a)(3) of the Securities Act of 1933;</p>

<p style="font-family:'Times New Roman';font-size:10pt;font-variant:normal;margin:0pt;">&nbsp;</p>

<p style="font-family:Times New Roman;font-size:10pt;font-variant:normal;text-align:justify;margin:0pt;text-indent:50pt;">(ii) To reflect in the prospectus any facts or events arising after the effective date of the registration statement (or the most recent post-effective amendment thereof) which, individually or in the aggregate, represent a fundamental change in the information set forth in the registration statement. Notwithstanding the foregoing, any increase or decrease in volume of securities offered (if the total dollar value of securities offered would not exceed that which was registered) and any deviation from the low or high end of the estimated maximum offering range may be reflected in the form of prospectus filed with the Commission pursuant to Rule 424(b) if, in the aggregate, the changes in volume and price represent no more than 20% change in the maximum aggregate offering price set forth in the &#8220;Calculation of Registration Fee&#8221; table in the effective registration statement; and</p>

<p style="font-family:'Times New Roman';font-size:10pt;font-variant:normal;margin:0pt;">&nbsp;</p>

<p style="font-family:Times New Roman;font-size:10pt;font-variant:normal;text-align:justify;margin:0pt;text-indent:50pt;">(iii) To include any material information with respect to the plan of distribution not previously disclosed in the registration statement or any material change to such information in the registration statement;</p>

<p style="font-family:'Times New Roman';font-size:10pt;font-variant:normal;margin:0pt;">&nbsp;</p>

<p style="font-family:Times New Roman;font-size:10pt;font-variant:normal;text-align:justify;margin:0pt;text-indent:36pt;"><i>Provided, however</i>, that paragraphs (a)(i) and (a)(ii) do not apply if the information required to be included in a post-effective amendment by those paragraphs is contained in reports filed with or furnished to the Commission by the registrant pursuant to Section 13 or Section 15(d) of the Securities Exchange Act of 1934 that are incorporated by reference in the registration statement.</p>

<p style="font-family:'Times New Roman';font-size:10pt;font-variant:normal;margin:0pt;">&nbsp;</p>

<p style="font-family:Times New Roman;font-size:10pt;font-variant:normal;text-align:justify;margin:0pt;text-indent:18pt;">(b) That, for the purpose of determining any liability under the Securities Act of 1933, each such post-effective amendment shall be deemed to be a new registration statement relating to the securities offered therein, and the offering of such securities at that time shall be deemed to be the initial bona fide offering thereof.</p>

<p style="font-family:'Times New Roman';font-size:10pt;font-variant:normal;margin:0pt;">&nbsp;</p>

<p style="font-family:Times New Roman;font-size:10pt;font-variant:normal;text-align:justify;margin:0pt;text-indent:18pt;">(c) To remove from registration by means of a post-effective amendment any of the securities being registered which remain unsold at the termination of the offering.</p>

<p style="font-family:'Times New Roman';font-size:10pt;font-variant:normal;margin:0pt;">&nbsp;</p>

<p style="font-family:Times New Roman;font-size:10pt;font-variant:normal;text-align:justify;margin:0pt;">2. The undersigned registrant hereby undertakes that, for purposes of determining any liability under the Securities Act of 1933, each filing of the registrant&#8217;s annual report pursuant to Section 13(a) or Section 15(d) of the Securities Exchange Act of 1934 (and, where applicable, each filing of an employee benefit plan&#8217;s annual report pursuant to Section 15(d) of the Securities Exchange Act of 1934) that is incorporated by reference in the Registration Statement shall be deemed to be a new registration statement relating to the securities offered herein, and the offering of such securities at that time shall be deemed to be the initial bona fide offering thereof.</p>

<p style="font-family:'Times New Roman';font-size:10pt;font-variant:normal;margin:0pt;">&nbsp;</p>

<p style="font-family:Times New Roman;font-size:10pt;font-variant:normal;text-align:justify;margin:0pt;">3. Insofar as indemnification for liabilities arising under the Securities Act of 1933 may be permitted to directors, officers and controlling persons of the registrant pursuant to the foregoing provisions, or otherwise, the registrant has been advised that in the opinion of the Securities and Exchange Commission such indemnification is against public policy as expressed in the Securities Act of 1933 and is, therefore, unenforceable. In the event that a claim for indemnification against such liabilities (other than the payment by the registrant of expenses incurred or paid by a director, officer or controlling person of the registrant in the successful defense of any action, suit or proceeding) is asserted by such director, officer or controlling person in connection with the securities being registered, the registrant will, unless in the opinion of its counsel the matter has been settled by controlling precedent, submit to a court of appropriate jurisdiction the question whether such indemnification by it is against public policy as expressed in the Securities Act of 1933 and will be governed by the final adjudication of such issue.</p>

<p style="font-family:'Times New Roman';font-size:10pt;font-variant:normal;margin:0pt;">&nbsp;</p>

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<div class="hf-cell PGNUM">&nbsp;</div>
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<p style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin: 0pt; text-align: left">&nbsp;</p>

<p style="font-family:Times New Roman;font-size:10pt;font-variant:normal;text-align:center;margin:0pt 0pt 0pt 8pt;"><b>SIGNATURES</b></p>

<p style="font-family:'Times New Roman';font-size:10pt;font-variant:normal;margin:0pt;">&nbsp;</p>

<p style="font-family:Times New Roman;font-size:10pt;font-variant:normal;text-align:justify;margin:0pt;">Pursuant to the requirements of the Securities Act of 1933, as amended, the Registrant certifies that it has reasonable grounds to believe that it meets all of the requirements for filing on Form&nbsp;S&#8209;8 and has duly caused this Registration Statement to be signed on its behalf by the undersigned, thereunto duly authorized, in the City of San Mateo, State of California, on May 20, 2024.</p>

<p style="font-family:Times New Roman;font-size:10pt;font-variant:normal;text-align:justify;margin:0pt;">&nbsp;</p>

<table border="0" cellpadding="0" cellspacing="0" style="font-family:Times New Roman;font-size:10pt;width:100%;margin-left:auto;margin-right:auto;">

		<tr>
			<td style="vertical-align: top; width: 50%;">&nbsp;</td>
			<td colspan="2" style="vertical-align: top; width: 2%;">
			<p style="font-family:Times New Roman;font-size:10pt;font-variant:normal;margin:0pt;"><b>TALPHERA, INC.</b></p>
			</td>
			<td style="vertical-align: top; width: 12%;">&nbsp;</td>
		</tr>
		<tr>
			<td style="vertical-align: top; width: 50%;">&nbsp;</td>
			<td style="vertical-align: top; width: 2%;">&nbsp;</td>
			<td style="vertical-align: bottom; width: 36%;">&nbsp;</td>
			<td style="vertical-align: top; width: 12%;">&nbsp;</td>
		</tr>
		<tr>
			<td style="vertical-align: top; width: 50%;">&nbsp;</td>
			<td style="vertical-align: top; width: 2%;">
			<p style="font-family:Times New Roman;font-size:10pt;font-variant:normal;margin:0pt;">By:</p>
			</td>
			<td style="border-bottom: 1px solid rgb(0, 0, 0); vertical-align: top; width: 36%;">
			<p style="font-family:Times New Roman;font-size:10pt;font-variant:normal;margin:0pt 0pt 0pt 9pt;">/s/ Vincent J. Angotti&nbsp;</p>
			</td>
			<td style="vertical-align: top; width: 12%;">&nbsp;</td>
		</tr>
		<tr>
			<td style="vertical-align: top; width: 50%;">&nbsp;</td>
			<td style="vertical-align: top; width: 2%;">&nbsp;</td>
			<td style="vertical-align: top; width: 36%;">
			<p style="font-family:Times New Roman;font-size:10pt;font-variant:normal;margin:0pt 0pt 0pt 18pt;">&nbsp;Vincent J. Angotti</p>
			</td>
			<td style="vertical-align: top; width: 12%;">&nbsp;</td>
		</tr>
		<tr>
			<td style="vertical-align: top; width: 50%;">&nbsp;</td>
			<td style="vertical-align: top; width: 2%;">&nbsp;</td>
			<td style="vertical-align: top; width: 36%;">
			<p style="font-family:Times New Roman;font-size:10pt;font-variant:normal;margin:0pt 0pt 0pt 18pt;"><i>&nbsp;Chief Executive Officer</i></p>
			</td>
			<td style="vertical-align: top; width: 12%;">&nbsp;</td>
		</tr>

</table>

<p style="font-family:'Times New Roman';font-size:10pt;font-variant:normal;margin:0pt;">&nbsp;</p>

<p style="font-family:Times New Roman;font-size:10pt;font-variant:normal;text-align:center;margin:0pt 0pt 0pt 8pt;"><b><a id="attorney" name="attorney" title="attorney"></a>POWER OF ATTORNEY</b></p>

<p style="font-family:'Times New Roman';font-size:10pt;font-variant:normal;margin:0pt;">&nbsp;</p>

<p style="font-family:Times New Roman;font-size:10pt;font-variant:normal;text-align:justify;margin:0pt;"><font style="font-variant:small-caps;"><b>Know all persons by these presents</b></font>, that each person whose signature appears below constitutes and appoints Vincent J. Angotti and Raffi Asadorian, and each or any one of them, his true and lawful attorney-in-fact and agent, with full power of substitution and resubstitution, for him and in his name, place and stead, in any and all capacities, to sign any and all amendments (including post-effective amendments) to this Registration Statement, and to file the same, with all exhibits thereto, and other documents in connection therewith, with the Securities and Exchange Commission, granting unto said attorneys-in-fact and agents, and each of them, full power and authority to do and perform each and every act and thing requisite and necessary to be done in connection therewith, as fully to all intents and purposes as he might or could do in person, hereby ratifying and confirming all that said attorneys-in-fact and agents, or any of them, or their or his substitutes or substitute, may lawfully do or cause to be done by virtue hereof.</p>

<p style="font-family:'Times New Roman';font-size:10pt;font-variant:normal;margin:0pt;">&nbsp;</p>

<p style="font-family:Times New Roman;font-size:10pt;font-variant:normal;text-align:justify;margin:0pt;">Pursuant to the requirements of the Securities Act of 1933, this Registration Statement has been signed by the following persons in the capacities and on the dates indicated.&nbsp;</p>

<p style="font-family:'Times New Roman';font-size:10pt;font-variant:normal;margin:0pt;">&nbsp;</p>

<table border="0" cellpadding="0" cellspacing="0" style="font-family:Times New Roman;font-size:10pt;width:100%;margin-left:auto;margin-right:auto;">

		<tr>
			<td style="border-bottom: 1px solid rgb(0, 0, 0); vertical-align: top; width: 15%;">
			<p style="font-family:Times New Roman;font-size:10pt;font-variant:normal;text-align:center;margin:0pt;"><b>Signature</b></p>
			</td>
			<td style="vertical-align: top; width: 1%;">&nbsp;</td>
			<td style="border-bottom: 1px solid rgb(0, 0, 0); vertical-align: top; width: 68%;">
			<p style="font-family:Times New Roman;font-size:10pt;font-variant:normal;text-align:center;margin:0pt;"><b>Title</b></p>
			</td>
			<td style="vertical-align: top; width: 1%;">&nbsp;</td>
			<td style="border-bottom: 1px solid rgb(0, 0, 0); vertical-align: top; width: 15%;">
			<p style="font-family:Times New Roman;font-size:10pt;font-variant:normal;text-align:center;margin:0pt;"><b>Date</b></p>
			</td>
		</tr>
		<tr>
			<td style="vertical-align: top; width: 15%;">&nbsp;</td>
			<td style="vertical-align: top; width: 1%;">&nbsp;</td>
			<td style="vertical-align: top; width: 68%;">&nbsp;</td>
			<td style="vertical-align: top; width: 1%;">&nbsp;</td>
			<td style="vertical-align: top; width: 15%;">&nbsp;</td>
		</tr>
		<tr>
			<td style="border-bottom: 1px solid rgb(0, 0, 0); vertical-align: top; width: 15%;">
			<p style="font-family:Times New Roman;font-size:10pt;font-variant:normal;text-align:center;margin:0pt;">/s/ Vincent J. Angotti</p>
			</td>
			<td style="vertical-align: top; width: 1%;">&nbsp;</td>
			<td style="vertical-align: top; width: 68%;">
			<p style="font-family:Times New Roman;font-size:10pt;font-variant:normal;text-align:center;margin:0pt;">Chief Executive Officer and Director</p>
			</td>
			<td style="vertical-align: top; width: 1%;">&nbsp;</td>
			<td style="vertical-align: top; width: 15%;">
			<p style="font-family:Times New Roman;font-size:10pt;font-variant:normal;text-align:center;margin:0pt;">May 20, 2024</p>
			</td>
		</tr>
		<tr>
			<td style="vertical-align: top; width: 15%;">
			<p style="font-family:Times New Roman;font-size:10pt;font-variant:normal;text-align:center;margin:0pt;">Vincent J. Angotti</p>
			</td>
			<td style="vertical-align: top; width: 1%;">&nbsp;</td>
			<td style="vertical-align: top; width: 68%;">
			<p style="font-family:Times New Roman;font-size:10pt;font-variant:normal;text-align:center;margin:0pt;"><i>(Principal Executive Officer)</i></p>
			</td>
			<td style="vertical-align: top; width: 1%;">&nbsp;</td>
			<td style="vertical-align: top; width: 15%;">&nbsp;</td>
		</tr>
		<tr>
			<td style="vertical-align: top; width: 15%;">&nbsp;</td>
			<td style="vertical-align: top; width: 1%;">&nbsp;</td>
			<td style="vertical-align: top; width: 68%;">&nbsp;</td>
			<td style="vertical-align: top; width: 1%;">&nbsp;</td>
			<td style="vertical-align: top; width: 15%;">&nbsp;</td>
		</tr>
		<tr>
			<td style="border-bottom: 1px solid rgb(0, 0, 0); vertical-align: top; width: 15%;">
			<p style="font-family:Times New Roman;font-size:10pt;font-variant:normal;text-align:center;margin:0pt;">/s/ Raffi Asadorian</p>
			</td>
			<td style="vertical-align: top; width: 1%;">&nbsp;</td>
			<td style="vertical-align: top; width: 68%;">
			<p style="font-family:Times New Roman;font-size:10pt;font-variant:normal;text-align:center;margin:0pt;">Chief Financial Officer</p>
			</td>
			<td style="vertical-align: top; width: 1%;">&nbsp;</td>
			<td style="vertical-align: top; width: 15%;">
			<p style="font-family:Times New Roman;font-size:10pt;font-variant:normal;text-align:center;margin:0pt;">May 20, 2024</p>
			</td>
		</tr>
		<tr>
			<td style="vertical-align: top; width: 15%;">
			<p style="font-family:Times New Roman;font-size:10pt;font-variant:normal;text-align:center;margin:0pt;">Raffi Asadorian</p>
			</td>
			<td style="vertical-align: top; width: 1%;">&nbsp;</td>
			<td style="vertical-align: top; width: 68%;">
			<p style="font-family:Times New Roman;font-size:10pt;font-variant:normal;text-align:center;margin:0pt;"><i>(Principal Financial and Accounting Officer)</i></p>
			</td>
			<td style="vertical-align: top; width: 1%;">&nbsp;</td>
			<td style="vertical-align: top; width: 15%;">&nbsp;</td>
		</tr>
		<tr>
			<td style="vertical-align: top; width: 15%;">&nbsp;</td>
			<td style="vertical-align: top; width: 1%;">&nbsp;</td>
			<td style="vertical-align: top; width: 68%;">&nbsp;</td>
			<td style="vertical-align: top; width: 1%;">&nbsp;</td>
			<td style="vertical-align: top; width: 15%;">&nbsp;</td>
		</tr>
		<tr>
			<td style="border-bottom: 1px solid rgb(0, 0, 0); vertical-align: top; width: 15%;">
			<p style="font-family:Times New Roman;font-size:10pt;font-variant:normal;text-align:center;margin:0pt;">/s/ Adrian Adams</p>
			</td>
			<td style="vertical-align: top; width: 1%;">&nbsp;</td>
			<td style="vertical-align: top; width: 68%;">
			<p style="font-family:Times New Roman;font-size:10pt;font-variant:normal;text-align:center;margin:0pt;">Chairman</p>
			</td>
			<td style="vertical-align: top; width: 1%;">&nbsp;</td>
			<td style="vertical-align: top; width: 15%;">
			<p style="font-family:Times New Roman;font-size:10pt;font-variant:normal;text-align:center;margin:0pt;">May 20, 2024</p>
			</td>
		</tr>
		<tr>
			<td style="vertical-align: top; width: 15%;">
			<p style="font-family:Times New Roman;font-size:10pt;font-variant:normal;text-align:center;margin:0pt;">Adrian Adams</p>
			</td>
			<td style="vertical-align: top; width: 1%;">&nbsp;</td>
			<td style="vertical-align: top; width: 68%;">&nbsp;</td>
			<td style="vertical-align: top; width: 1%;">&nbsp;</td>
			<td style="vertical-align: top; width: 15%;">&nbsp;</td>
		</tr>
		<tr>
			<td style="vertical-align: top; width: 15%;">&nbsp;</td>
			<td style="vertical-align: top; width: 1%;">&nbsp;</td>
			<td style="vertical-align: top; width: 68%;">&nbsp;</td>
			<td style="vertical-align: top; width: 1%;">&nbsp;</td>
			<td style="vertical-align: top; width: 15%;">&nbsp;</td>
		</tr>
		<tr>
			<td style="border-bottom: 1px solid rgb(0, 0, 0); vertical-align: top; width: 15%;">
			<p style="font-family:Times New Roman;font-size:10pt;font-variant:normal;text-align:center;margin:0pt;">/s/ Marina Bozilenko</p>
			</td>
			<td style="vertical-align: top; width: 1%;">&nbsp;</td>
			<td style="vertical-align: top; width: 68%;">
			<p style="font-family:Times New Roman;font-size:10pt;font-variant:normal;text-align:center;margin:0pt;">Director</p>
			</td>
			<td style="vertical-align: top; width: 1%;">&nbsp;</td>
			<td style="vertical-align: top; width: 15%;">
			<p style="font-family:Times New Roman;font-size:10pt;font-variant:normal;text-align:center;margin:0pt;">May 20, 2024</p>
			</td>
		</tr>
		<tr>
			<td style="vertical-align: top; width: 15%;">
			<p style="font-family:Times New Roman;font-size:10pt;font-variant:normal;text-align:center;margin:0pt;">Marina Bozilenko</p>
			</td>
			<td style="vertical-align: top; width: 1%;">&nbsp;</td>
			<td style="vertical-align: top; width: 68%;">&nbsp;</td>
			<td style="vertical-align: top; width: 1%;">&nbsp;</td>
			<td style="vertical-align: top; width: 15%;">&nbsp;</td>
		</tr>
		<tr>
			<td style="vertical-align: top; width: 15%;">&nbsp;</td>
			<td style="vertical-align: top; width: 1%;">&nbsp;</td>
			<td style="vertical-align: top; width: 68%;">&nbsp;</td>
			<td style="vertical-align: top; width: 1%;">&nbsp;</td>
			<td style="vertical-align: top; width: 15%;">&nbsp;</td>
		</tr>
		<tr>
			<td style="border-bottom: 1px solid rgb(0, 0, 0); vertical-align: top; width: 15%;">
			<p style="font-family:Times New Roman;font-size:10pt;font-variant:normal;text-align:center;margin:0pt;">/s/ Jill Broadfoot</p>
			</td>
			<td style="vertical-align: top; width: 1%;">&nbsp;</td>
			<td style="vertical-align: top; width: 68%;">
			<p style="font-family:Times New Roman;font-size:10pt;font-variant:normal;text-align:center;margin:0pt;">Director</p>
			</td>
			<td style="vertical-align: top; width: 1%;">&nbsp;</td>
			<td style="vertical-align: top; width: 15%;">
			<p style="font-family:Times New Roman;font-size:10pt;font-variant:normal;text-align:center;margin:0pt;">May 20, 2024</p>
			</td>
		</tr>
		<tr>
			<td style="vertical-align: top; width: 15%;">
			<p style="font-family:Times New Roman;font-size:10pt;font-variant:normal;text-align:center;margin:0pt;">Jill Broadfoot</p>
			</td>
			<td style="vertical-align: top; width: 1%;">&nbsp;</td>
			<td style="vertical-align: top; width: 68%;">&nbsp;</td>
			<td style="vertical-align: top; width: 1%;">&nbsp;</td>
			<td style="vertical-align: top; width: 15%;">&nbsp;</td>
		</tr>
		<tr>
			<td style="vertical-align: top; width: 15%;">&nbsp;</td>
			<td style="vertical-align: top; width: 1%;">&nbsp;</td>
			<td style="vertical-align: top; width: 68%;">&nbsp;</td>
			<td style="vertical-align: top; width: 1%;">&nbsp;</td>
			<td style="vertical-align: top; width: 15%;">&nbsp;</td>
		</tr>
		<tr>
			<td style="border-bottom: 1px solid rgb(0, 0, 0); vertical-align: top; width: 15%;">
			<p style="font-family:Times New Roman;font-size:10pt;font-variant:normal;text-align:center;margin:0pt;">/s/ Stephen J. Hoffman</p>
			</td>
			<td style="vertical-align: top; width: 1%;">&nbsp;</td>
			<td style="vertical-align: top; width: 68%;">
			<p style="font-family:Times New Roman;font-size:10pt;font-variant:normal;text-align:center;margin:0pt;">Director</p>
			</td>
			<td style="vertical-align: top; width: 1%;">&nbsp;</td>
			<td style="vertical-align: top; width: 15%;">
			<p style="font-family:Times New Roman;font-size:10pt;font-variant:normal;text-align:center;margin:0pt;">May 20, 2024</p>
			</td>
		</tr>
		<tr>
			<td style="vertical-align: top; width: 15%;">
			<p style="font-family:Times New Roman;font-size:10pt;font-variant:normal;text-align:center;margin:0pt;">Stephen J. Hoffman</p>
			</td>
			<td style="vertical-align: top; width: 1%;">&nbsp;</td>
			<td style="vertical-align: top; width: 68%;">&nbsp;</td>
			<td style="vertical-align: top; width: 1%;">&nbsp;</td>
			<td style="vertical-align: top; width: 15%;">&nbsp;</td>
		</tr>
		<tr>
			<td style="vertical-align: top; width: 15%;">&nbsp;</td>
			<td style="vertical-align: top; width: 1%;">&nbsp;</td>
			<td style="vertical-align: top; width: 68%;">&nbsp;</td>
			<td style="vertical-align: top; width: 1%;">&nbsp;</td>
			<td style="vertical-align: top; width: 15%;">&nbsp;</td>
		</tr>
		<tr>
			<td style="border-bottom: 1px solid rgb(0, 0, 0); vertical-align: top; width: 15%;">
			<p style="font-family:Times New Roman;font-size:10pt;font-variant:normal;text-align:center;margin:0pt;">/s/ Abhinav Jain</p>
			</td>
			<td style="vertical-align: top; width: 1%;">&nbsp;</td>
			<td style="vertical-align: top; width: 68%;">
			<p style="font-family:Times New Roman;font-size:10pt;font-variant:normal;text-align:center;margin:0pt;">Director</p>
			</td>
			<td style="vertical-align: top; width: 1%;">&nbsp;</td>
			<td style="vertical-align: top; width: 15%;">
			<p style="font-family:Times New Roman;font-size:10pt;font-variant:normal;text-align:center;margin:0pt;">May 20, 2024</p>
			</td>
		</tr>
		<tr>
			<td style="vertical-align: top; width: 15%;">
			<p style="font-family:Times New Roman;font-size:10pt;font-variant:normal;text-align:center;margin:0pt;">Abhinav Jain</p>
			</td>
			<td style="vertical-align: top; width: 1%;">&nbsp;</td>
			<td style="vertical-align: top; width: 68%;">&nbsp;</td>
			<td style="vertical-align: top; width: 1%;">&nbsp;</td>
			<td style="vertical-align: top; width: 15%;">&nbsp;</td>
		</tr>
		<tr>
			<td style="vertical-align: top; width: 15%;">&nbsp;</td>
			<td style="vertical-align: top; width: 1%;">&nbsp;</td>
			<td style="vertical-align: top; width: 68%;">&nbsp;</td>
			<td style="vertical-align: top; width: 1%;">&nbsp;</td>
			<td style="vertical-align: top; width: 15%;">&nbsp;</td>
		</tr>
		<tr>
			<td style="border-bottom: 1px solid rgb(0, 0, 0); vertical-align: top; width: 15%;">
			<p style="font-family:Times New Roman;font-size:10pt;font-variant:normal;text-align:center;margin:0pt;">/s/ Mark Wan</p>
			</td>
			<td style="vertical-align: top; width: 1%;">&nbsp;</td>
			<td style="vertical-align: top; width: 68%;">
			<p style="font-family:Times New Roman;font-size:10pt;font-variant:normal;text-align:center;margin:0pt;">Director</p>
			</td>
			<td style="vertical-align: top; width: 1%;">&nbsp;</td>
			<td style="vertical-align: top; width: 15%;">
			<p style="font-family:Times New Roman;font-size:10pt;font-variant:normal;text-align:center;margin:0pt;">May 20, 2024</p>
			</td>
		</tr>
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[{"type": "S-8", "sequence": "1", "filename": "acrx20240518_s8.htm", "description": "FORM S-8", "secsgml_size_bytes": 89913}]
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acrx20240518_s8.htm
As filed with the Securities and Exchange Commission on May 20, 2024
Registration No. 333-
UNITED STATES
SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM S-8
REGISTRATION STATEMENT
UNDER
THE SECURITIES ACT OF 1933
TALPHERA, INC.
(Exact name of registrant as specified in its charter)
Delaware
41-2193603
(State or other jurisdiction of Incorporation or organization)
(I.R.S. Employer Identification No.)
1850 Gateway Drive, Suite 175
San Mateo, CA 94404
(Address of principal executive offices) (Zip code)
Non-Plan Inducement Stock Option Grant
Non-Plan Inducement Restricted Stock Unit Award
(Full title of the plan)
Raffi Asadorian
Chief Financial Officer
Talphera, Inc.
1850 Gateway Drive, Suite 175
San Mateo, CA 94404
(650) 216-3500
(Name and address of agent for service) (Telephone number, including area code, of agent for service)
Copy to:
John T. McKenna
Cooley LLP
3175 Hanover Street
Palo Alto, California 94304
(650) 843-5000
Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, a smaller reporting company, or an emerging growth company. See the definitions of "large accelerated filer," "accelerated filer," "smaller reporting company," and "emerging growth company" in Rule 12b-2 of the Exchange Act.
Large accelerated filer ☐
Accelerated filer ☐
Non-accelerated filer ☒
Smaller reporting company ☒
Emerging growth company ☐
If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 7(a)(2)(B) of the Securities Act.  ☐
EXPLANATORY NOTE
Talphera, Inc. (the "Registrant") is filing this registration statement on Form S-8 (the "Registration Statement") with the Securities and Exchange Commission (the "SEC") for the purpose of registering:
•
185,000 shares of its common stock, par value $0.001 per share (the "Common Stock") issuable upon the exercise of an inducement stock option grant, and
•
32,000 shares of Common Stock issuable upon the vesting of a restricted stock unit award,
each to be granted to Dr. Shakil Aslam on May 20, 2024, as an inducement for accepting employment with the Registrant as Chief Development Officer (collectively, the "Inducement Awards"). The Inducement Awards will be granted outside of the Registrant's Amended and Restated 2020 Equity Incentive Plan pursuant to the "inducement" grant exception under Nasdaq Listing Rule 5635(c)(4) and have been approved by the Registrant's Board of Directors.
PART I
INFORMATION REQUIRED IN THE SECTION 10(a) PROSPECTUS
Information required by Part I of Form S-8 to be contained in the Section 10(a) prospectus is omitted from this Registration Statement in accordance with Rule 428 under the Securities Act of 1933, as amended (the "Securities Act"). The document(s) containing the information specified in Part I will be sent or given to the participant in the Inducement Awards pursuant to Rule 428(b)(1). Such document(s) are not being filed with the SEC as part of this Registration Statement or as prospectuses or prospectus supplements pursuant to Rule 424 of the Securities Act. These document(s) and the documents incorporated by reference in the Registration Statement pursuant to Item 3 of Part II of this form, taken together, constitute a prospectus that meets the requirements of Section 10(a) of the Securities Act.
PART II
INFORMATION REQUIRED IN THE REGISTRATION STATEMENT
Item 3.
Incorporation of Documents by Reference.
The following documents filed by the Registrant with the SEC are incorporated by reference into this Registration Statement (other than information in such filings deemed, under SEC rules, not to have been filed with the SEC):
(a)
the Registrant's
Annual Report on Form 10-K for the year ended December 31, 2023, filed with the SEC on March 6, 2024 (the "
2023 10-K
");
(b)
the Registrant's Current Reports on Form 8-K, filed with the SEC on
January 9, 2024
(other than Item 7.01),
January 18, 2024
,
January 22, 2024
(other than Item 2.02 and Item 7.01),
March 1, 2024
and
April 19, 2024
; and
(c)
the Registrant's information specifically incorporated by reference in the 2023 10-K from the Registrant's
definitive proxy statement on Schedule 14A for the 2024 annual meeting of stockholders, filed with the SEC on April 29, 2024
;
(d)
the Registrant's
Quarterly Report on Form 10-Q for the quarter ended March 31, 2024 filed with the SEC on May 14, 2024
; and
(e)
the description of the Registrant's Common Stock which is contained in a registration statement on
Form 8-A filed with the SEC on February 1, 2011
under the Securities Exchange Act of 1934, as amended (the "Exchange Act"), including any amendment or report filed for the purpose of updating such description, including
Exhibit 4.1
of the Registrant's Annual Report on Form 10-K for the year ended December 31, 2020, filed with the SEC on March 15, 2021.
All other reports and documents subsequently filed by the Registrant pursuant to Sections 13(a), 13(c), 14 and 15(d) of the Exchange Act (other than Current Reports furnished under Item 2.02 or Item 7.01 of Form 8-K and exhibits furnished on such form that relate to such items) on or after the date of this Registration Statement and prior to the filing of a post-effective amendment to this Registration Statement which indicates that all securities offered have been sold or which deregisters all securities then remaining unsold, shall be deemed to be incorporated by reference herein and to be a part of this Registration Statement from the date of the filing of such reports and documents. Any statement contained in a document incorporated or deemed to be incorporated by reference herein shall be deemed to be modified or superseded for purposes of this Registration Statement to the extent that a statement contained herein or in any subsequently filed document that also is deemed to be incorporated by reference herein modifies or supersedes such statement. Any such statement so modified or superseded shall not be deemed, except as so modified or superseded, to constitute a part of this Registration Statement.
Item 4. Description of Securities
Not applicable.
Item 5. Interests of Named Experts and Counsel
Not applicable.
Item 6. Indemnification of Directors and Officers
The following summary is qualified in its entirety by reference to the complete copy of the Delaware General Corporation Law, the Registrant's amended and restated certificate of incorporation, as amended, and the Registrant's amended and restated bylaws. Section 145 of the Delaware General Corporation Law authorizes a court to award, or a corporation's board of directors to grant indemnity to directors and officers under certain circumstances and subject to certain limitations. The terms of Section 145 of the Delaware General Corporation Law are sufficiently broad to permit indemnification under certain circumstances for liabilities, including reimbursement of expenses incurred, arising under the Securities Act.
As permitted by the Delaware General Corporation Law, the Registrant's amended and restated certificate of incorporation, as amended, contains provisions that eliminate the personal liability of its directors for monetary damages for any breach of fiduciary duties as a director, except liability for the following:
●
any breach of the director's duty of loyalty to the Registrant or its stockholders;
●
acts or omissions not in good faith or that involve intentional misconduct or a knowing violation of law;
●
under Section 174 of the Delaware General Corporation Law (regarding unlawful dividends and stock purchases); or
●
any transaction from which the director derived an improper personal benefit.
As permitted by the Delaware General Corporation Law, the Registrant's amended and restated bylaws provide that:
●
the Registrant is required to indemnify its directors and executive officers to the fullest extent permitted by the Delaware General Corporation Law, subject to very limited exceptions;
●
the Registrant may indemnify its other employees and agents as set forth in the Delaware General Corporation Law;
●
the Registrant is required to advance expenses, as incurred, to its directors and executive officers in connection with a legal proceeding to the fullest extent permitted by the Delaware General Corporation Law, subject to very limited exceptions; and
●
the rights conferred in the Registrant's amended and restated bylaws are not exclusive.
The Registrant has entered, and intends to continue to enter, into separate indemnification agreements with its directors and executive officers to provide these directors and executive officers additional contractual assurances regarding the scope of the indemnification set forth in the Registrant's amended and restated certificate of incorporation, as amended, and amended and restated bylaws and to provide additional procedural protections. The indemnification provisions in the Registrant's amended and restated certificate of incorporation, as amended, amended and restated bylaws and the indemnification agreements entered into or to be entered into between the Registrant and each of its directors and executive officers may be sufficiently broad to permit indemnification of the Registrant's directors and executive officers for liabilities arising under the Securities Act. Insofar as indemnification for liabilities arising under the Securities Act may be permitted to directors, officers and controlling persons of the Registrant pursuant to the foregoing provisions, or otherwise, the Registrant has been advised that in the opinion of the Commission such indemnification is against public policy as expressed in the Securities Act and is, therefore, unenforceable.
The Registrant currently carries liability insurance for its directors and officers.
Item 7. Exemption from Registration Claimed
Not applicable.
Item 8.
Exhibits.
Incorporation by Reference
Exhibit
Number
Exhibit Description
Form
SEC File No.
Exhibit
Filing Date
3.1
Amended and Restated Certificate of Incorporation of the Registrant.
8-K
001-35068
3.1
2/18/2011
3.2
Certificate of Amendment of Amended and Restated Certificate of Incorporation of the Registrant.
8-K
001-35068
3.1
1/9/2024
3.3
Certificate of Amendment of Amended and Restated Certificate of Incorporation of the Registrant.
8-K
001-35068
3.1
6/25/2019
3.4
Certificate of Amendment of Amended and Restated Certificate of Incorporation of the Registrant.
8-K
001-35068
3.1
10/25/2022
3.5
Amended and Restated Bylaws of the Registrant.
8-K
001-35068
3.2
1/9/2024
4.1
Reference is made to Exhibits 3.1 through 3.4.
4.2
Specimen Common Stock Certificate of the Registrant.
S-1/A
333-170594
4.2
1/31/2011
5.1
Opinion of Cooley LLP.
23.1
Consent of BPM LLP, Independent Registered Public Accounting Firm.
23.2
Consent of Withum Smith & Brown LLP, Independent Registered Public Accounting Firm.
23.3
Consent of Cooley LLP (included in Exhibit 5.1).
24.1
Power of Attorney (included on the signature page of this Form S-8).
99.1+
Amended and Restated 2020 Equity Incentive Plan.
8-K
001-35068
10.1
10/10/2023
99.2*+
Inducement Stock Option Grant and Award Agreement by and between Talphera, Inc. and Dr. Shakil Aslam.
99.3*+
Inducement Restricted Stock Unit Grant Notice and Award Agreement by and between Talphera, Inc. and Dr. Shakil Aslam.
107
Filing Fee Table
+
Indicates management contract or compensatory plan.
*
Filed herewith
Item 9. Undertakings
1. The undersigned registrant hereby undertakes:
(a) To file, during any period in which offers or sales are being made, a post-effective amendment to this registration statement:
(i) To include any prospectus required by Section 10(a)(3) of the Securities Act of 1933;
(ii) To reflect in the prospectus any facts or events arising after the effective date of the registration statement (or the most recent post-effective amendment thereof) which, individually or in the aggregate, represent a fundamental change in the information set forth in the registration statement. Notwithstanding the foregoing, any increase or decrease in volume of securities offered (if the total dollar value of securities offered would not exceed that which was registered) and any deviation from the low or high end of the estimated maximum offering range may be reflected in the form of prospectus filed with the Commission pursuant to Rule 424(b) if, in the aggregate, the changes in volume and price represent no more than 20% change in the maximum aggregate offering price set forth in the "Calculation of Registration Fee" table in the effective registration statement; and
(iii) To include any material information with respect to the plan of distribution not previously disclosed in the registration statement or any material change to such information in the registration statement;
Provided, however
, that paragraphs (a)(i) and (a)(ii) do not apply if the information required to be included in a post-effective amendment by those paragraphs is contained in reports filed with or furnished to the Commission by the registrant pursuant to Section 13 or Section 15(d) of the Securities Exchange Act of 1934 that are incorporated by reference in the registration statement.
(b) That, for the purpose of determining any liability under the Securities Act of 1933, each such post-effective amendment shall be deemed to be a new registration statement relating to the securities offered therein, and the offering of such securities at that time shall be deemed to be the initial bona fide offering thereof.
(c) To remove from registration by means of a post-effective amendment any of the securities being registered which remain unsold at the termination of the offering.
2. The undersigned registrant hereby undertakes that, for purposes of determining any liability under the Securities Act of 1933, each filing of the registrant's annual report pursuant to Section 13(a) or Section 15(d) of the Securities Exchange Act of 1934 (and, where applicable, each filing of an employee benefit plan's annual report pursuant to Section 15(d) of the Securities Exchange Act of 1934) that is incorporated by reference in the Registration Statement shall be deemed to be a new registration statement relating to the securities offered herein, and the offering of such securities at that time shall be deemed to be the initial bona fide offering thereof.
3. Insofar as indemnification for liabilities arising under the Securities Act of 1933 may be permitted to directors, officers and controlling persons of the registrant pursuant to the foregoing provisions, or otherwise, the registrant has been advised that in the opinion of the Securities and Exchange Commission such indemnification is against public policy as expressed in the Securities Act of 1933 and is, therefore, unenforceable. In the event that a claim for indemnification against such liabilities (other than the payment by the registrant of expenses incurred or paid by a director, officer or controlling person of the registrant in the successful defense of any action, suit or proceeding) is asserted by such director, officer or controlling person in connection with the securities being registered, the registrant will, unless in the opinion of its counsel the matter has been settled by controlling precedent, submit to a court of appropriate jurisdiction the question whether such indemnification by it is against public policy as expressed in the Securities Act of 1933 and will be governed by the final adjudication of such issue.
SIGNATURES
Pursuant to the requirements of the Securities Act of 1933, as amended, the Registrant certifies that it has reasonable grounds to believe that it meets all of the requirements for filing on Form S‑8 and has duly caused this Registration Statement to be signed on its behalf by the undersigned, thereunto duly authorized, in the City of San Mateo, State of California, on May 20, 2024.
TALPHERA, INC.
By:
/s/ Vincent J. Angotti
Vincent J. Angotti
Chief Executive Officer
POWER OF ATTORNEY
Know all persons by these presents
, that each person whose signature appears below constitutes and appoints Vincent J. Angotti and Raffi Asadorian, and each or any one of them, his true and lawful attorney-in-fact and agent, with full power of substitution and resubstitution, for him and in his name, place and stead, in any and all capacities, to sign any and all amendments (including post-effective amendments) to this Registration Statement, and to file the same, with all exhibits thereto, and other documents in connection therewith, with the Securities and Exchange Commission, granting unto said attorneys-in-fact and agents, and each of them, full power and authority to do and perform each and every act and thing requisite and necessary to be done in connection therewith, as fully to all intents and purposes as he might or could do in person, hereby ratifying and confirming all that said attorneys-in-fact and agents, or any of them, or their or his substitutes or substitute, may lawfully do or cause to be done by virtue hereof.
Pursuant to the requirements of the Securities Act of 1933, this Registration Statement has been signed by the following persons in the capacities and on the dates indicated.
Signature
Title
Date
/s/ Vincent J. Angotti
Chief Executive Officer and Director
May 20, 2024
Vincent J. Angotti
(Principal Executive Officer)
/s/ Raffi Asadorian
Chief Financial Officer
May 20, 2024
Raffi Asadorian
(Principal Financial and Accounting Officer)
/s/ Adrian Adams
Chairman
May 20, 2024
Adrian Adams
/s/ Marina Bozilenko
Director
May 20, 2024
Marina Bozilenko
/s/ Jill Broadfoot
Director
May 20, 2024
Jill Broadfoot
/s/ Stephen J. Hoffman
Director
May 20, 2024
Stephen J. Hoffman
/s/ Abhinav Jain
Director
May 20, 2024
Abhinav Jain
/s/ Mark Wan
Director
May 20, 2024
Mark Wan