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<TITLE>Form S-8</TITLE>
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<P align="center" style="font-size: 10pt">As filed with the
Securities and Exchange Commission on June&nbsp;16, 2005

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<P align="center" style="font-size: 14pt"><B>SECURITIES AND EXCHANGE COMMISSION</B>

<DIV align="center" style="font-size: 12pt"><B>Washington, D.C. 20549</B>
</DIV>


<P align="center" style="font-size: 10pt"><DIV align="center"><DIV style="font-size: 3pt; margin-top: 16pt; width: 46%; border-top: 1px solid #000000">&nbsp;</DIV></DIV>


<P align="center" style="font-size: 18pt"><B>FORM S-8</B>


<P align="center" style="font-size: 12pt"><B>REGISTRATION STATEMENT<BR>
UNDER<BR>
THE SECURITIES ACT OF 1933</B>



<P align="center" style="font-size: 10pt"><DIV align="center"><DIV style="font-size: 3pt; margin-top: 16pt; width: 46%; border-top: 1px solid #000000">&nbsp;</DIV></DIV>


<P align="center" style="font-size: 24pt"><B>CARDIOME PHARMA CORP.</B>


<DIV align="center" style="font-size: 10pt">(Exact name of registrant as specified in its charter)</DIV>


<DIV align="center">
<TABLE style="font-size: 10pt" cellspacing="0" border="0" cellpadding="0" width="100%">
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    <TD width="5%">&nbsp;</TD>
    <TD width="47%">&nbsp;</TD>
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<TR valign="bottom">
    <TD align="center" valign="top"><B>Canada</B><BR>
<DIV align="center"><DIV style="font-size: 3pt; margin-top: 3pt; width: 46%; border-top: 1px solid #000000">&nbsp;</DIV></DIV>
(State or other jurisdiction of<BR>
incorporation or organization)
</TD>
    <TD>&nbsp;</TD>
    <TD align="center" valign="top"><B>Not Applicable</B><BR>
<DIV align="center"><DIV style="font-size: 3pt; margin-top: 3pt; width: 46%; border-top: 1px solid #000000">&nbsp;</DIV></DIV>
(IRS Employer<BR>
Identification No.)</TD>
</TR>
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</DIV>


<P align="center" style="font-size: 10pt"><B>6th Floor, 6190 Agronomy Road<BR>
Vancouver, British Columbia<BR>
Canada V6T 1Z3<BR>
(604)&nbsp;667-6905</B><BR>
(Address of registrant&#146;s Principal Executive Offices)



<P align="center" style="font-size: 10pt"><DIV align="center"><DIV style="font-size: 3pt; margin-top: 16pt; width: 46%; border-top: 1px solid #000000">&nbsp;</DIV></DIV>



<P align="center" style="font-size: 10pt"><B>AMENDED 2001 INCENTIVE STOCK OPTION PLAN</B><BR>
(Full title of the plan)



<P align="center" style="font-size: 10pt"><DIV align="center"><DIV style="font-size: 3pt; margin-top: 16pt; width: 46%; border-top: 1px solid #000000">&nbsp;</DIV></DIV>


<P align="center" style="font-size: 10pt">PTSGE Corp.<BR>
925 Fourth Avenue, Suite&nbsp;2900<BR>
Seattle, Washington 98104<BR>
(206)&nbsp;623-7580<BR>
(Name, address, including ZIP code, and telephone number, including area code, of agent for service)



<P align="center" style="font-size: 10pt">Copies to:<BR>
Annette Elinger Becker, Esq.<BR>
Devin W. Stockfish, Esq.<BR>
Preston Gates &#038; Ellis LLP<BR>
925 Fourth Avenue, Suite&nbsp;2900<BR>
Seattle, WA 98104<BR>
(206)&nbsp;623-7580











<P align="center" style="font-size: 10pt"><B>CALCULATION OF REGISTRATION FEE</B>


<DIV align="center">
<TABLE style="font-size: 10pt" cellspacing="0" border="0" cellpadding="0" width="100%">
<!-- Begin Table Head -->
<TR valign="bottom">
    <TD width="38%">&nbsp;</TD>
    <TD width="3%">&nbsp;</TD>
    <TD width="3%">&nbsp;</TD>
    <TD width="9%">&nbsp;</TD>
    <TD width="3%">&nbsp;</TD>
    <TD width="3%">&nbsp;</TD>
    <TD width="3%">&nbsp;</TD>
    <TD width="5%">&nbsp;</TD>
    <TD width="3%">&nbsp;</TD>
    <TD width="3%">&nbsp;</TD>
    <TD width="3%">&nbsp;</TD>
    <TD width="9%">&nbsp;</TD>
    <TD width="3%">&nbsp;</TD>
    <TD width="3%">&nbsp;</TD>
    <TD width="2%">&nbsp;</TD>
    <TD width="5%">&nbsp;</TD>
    <TD width="2%">&nbsp;</TD>
</TR>
<TR style="font-size: 8pt" valign="bottom">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD nowrap align="center" colspan="3">Proposed maximum</TD>
    <TD>&nbsp;</TD>
    <TD nowrap align="center" colspan="3">Proposed maximum</TD>
    <TD>&nbsp;</TD>
    <TD nowrap align="center" colspan="3">&nbsp;</TD>
</TR>
<TR style="font-size: 8pt" valign="bottom">
    <TD nowrap align="center">Title of each class of</TD>
    <TD>&nbsp;</TD>
    <TD nowrap align="center" colspan="3">Amount to be</TD>
    <TD>&nbsp;</TD>
    <TD nowrap align="center" colspan="3">offering price per</TD>
    <TD>&nbsp;</TD>
    <TD nowrap align="center" colspan="3">aggregate offering</TD>
    <TD>&nbsp;</TD>
    <TD nowrap align="center" colspan="3">Amount of</TD>
</TR>
<TR style="font-size: 8pt" valign="bottom">
    <TD nowrap align="center" style="border-bottom: 1px solid #000000">securities to be registered</TD>
    <TD>&nbsp;</TD>
    <TD nowrap align="center" colspan="3" style="border-bottom: 1px solid #000000">registered (1)(2)</TD>
    <TD>&nbsp;</TD>
    <TD nowrap align="center" colspan="3" style="border-bottom: 1px solid #000000">share</TD>
    <TD>&nbsp;</TD>
    <TD nowrap align="center" colspan="3" style="border-bottom: 1px solid #000000">price (2)</TD>
    <TD>&nbsp;</TD>
    <TD nowrap align="center" colspan="3" style="border-bottom: 1px solid #000000">registration fee</TD>
</TR>

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<TR valign="bottom">
    <TD><DIV style="margin-left:15px; text-indent:-15px">Common Shares, without
par value</DIV></TD>
    <TD>&nbsp;</TD>
    <TD colspan="3" align="center" nowrap>4,990,068 shares (3)</TD>
    <TD>&nbsp;</TD>
    <TD nowrap align="left">&nbsp;</TD>
    <TD align="center">$4.01&nbsp;(4)</TD>
    <TD nowrap>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD align="left">&nbsp;</TD>
    <TD align="center">$20,010,172.68</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD align="left">&nbsp;</TD>
    <TD align="center">$2,355.20</TD>
    <TD>&nbsp;</TD>
</TR>
<TR valign="bottom"><!-- Blank Space -->
    <TD><DIV style="margin-left:15px; text-indent:-15px">&nbsp;</DIV></TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
</TR>
<TR valign="bottom">
    <TD><DIV style="margin-left:15px; text-indent:-15px">Common Shares, without
par value</DIV></TD>
    <TD>&nbsp;</TD>
    <TD colspan="3" align="center">759,932 shares (5)</TD>
    <TD>&nbsp;</TD>
    <TD nowrap align="left">&nbsp;</TD>
    <TD align="center">$5.62&nbsp;(6)</TD>
    <TD nowrap>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD align="left">&nbsp;</TD>
    <TD align="center">$4,270,817.84</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD align="left">&nbsp;</TD>
    <TD align="center">$502.68</TD>
    <TD>&nbsp;</TD>
</TR>
<TR valign="bottom"><!-- Blank Space -->
    <TD><DIV style="margin-left:15px; text-indent:-15px">&nbsp;</DIV></TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
</TR>
<TR valign="bottom">
    <TD><DIV style="margin-left:45px; text-indent:-15px">TOTAL</DIV></TD>
    <TD>&nbsp;</TD>
    <TD colspan="3" align="center">5,750,000 shares</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD align="left">&nbsp;</TD>
    <TD align="center">$24,280,990.52</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD align="left">&nbsp;</TD>
    <TD align="center">$2,857.87</TD>
    <TD>&nbsp;</TD>
</TR>
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</TABLE>
</DIV>


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<TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
    <TD width="1%" nowrap align="left">(1)</TD>
    <TD width="1%">&nbsp;</TD>
    <TD>Pursuant to Rule 416(a) under the Securities Act of 1933, as amended (the &#147;Securities Act&#148;),
this Registration Statement shall also cover any additional Common Shares that become issuable
under the Amended 2001 Incentive Stock Option Plan (the &#147;Plan&#148;) by reason of any stock
dividend, stock split, recapitalization or other similar transaction effected without receipt
of consideration that increases the number of the registrant&#146;s outstanding Common Shares.</TD>
</TR>

<TR>
    <TD colspan="5">&nbsp;</TD>
</TR>
<TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
    <TD width="1%" nowrap align="left">(2)</TD>
    <TD width="1%">&nbsp;</TD>
    <TD>For the sole purpose of calculation of the registration fee, the number of shares to be
registered under this Registration Statement has been broken down into two subtotals.</TD>
</TR>

<TR>
    <TD colspan="5">&nbsp;</TD>
</TR>
<TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
    <TD width="1%" nowrap align="left">(3)</TD>
    <TD width="1%">&nbsp;</TD>
    <TD>This subtotal represents the aggregate number of shares issuable upon exercise of presently
outstanding options issued under the Plan.</TD>
</TR>

<TR>
    <TD colspan="5">&nbsp;</TD>
</TR>
<TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
    <TD width="1%" nowrap align="left">(4)</TD>
    <TD width="1%">&nbsp;</TD>
    <TD>Computed in accordance with Rule 457(h) under the Securities Act, solely for the purpose of
calculating the registration fee, based on the weighted average exercise price (rounded to the
nearest cent and converted at the exchange rate posted on June&nbsp;3, 2005) for outstanding
options granted pursuant to the Plan.</TD>
</TR>

<TR>
    <TD colspan="5">&nbsp;</TD>
</TR>
<TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
    <TD width="1%" nowrap align="left">(5)</TD>
    <TD width="1%">&nbsp;</TD>
    <TD>This subtotal represents the aggregate number of shares reserved for future option grants
under the Plan.</TD>
</TR>

<TR>
    <TD colspan="5">&nbsp;</TD>
</TR>
<TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
    <TD width="1%" nowrap align="left">(6)</TD>
    <TD width="1%">&nbsp;</TD>
    <TD>Computed in accordance with Rule 457(h) and Rule 457(c) under the Securities Act, solely for
the purpose of calculating the registration fee, based on the average of the high and low
prices of the Common Shares as reported by The Nasdaq Stock Market on June&nbsp;10, 2005.</TD>
</TR>




</TABLE>



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<P align="center" style="font-size: 10pt">&nbsp;
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<A name="toc"><DIV align="CENTER"><U><B>TABLE OF CONTENTS</B></U></DIV></A>

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<TR><TD colspan="9"><A HREF="#000"> PART I. INFORMATION REQUIRED IN THE SECTION 10(a) PROSPECTUS</A></TD></TR>
<TR><TD colspan="9"><A HREF="#001"> PART II. INFORMATION REQUIRED IN THE REGISTRATION STATEMENT</A></TD></TR>
<TR><TD></TD><TD colspan="8"><A HREF="#002">Item&nbsp;3. Incorporation of Documents by Reference</A></TD></TR>
<TR><TD></TD><TD colspan="8"><A HREF="#003">Item&nbsp;4. Description of Securities</A></TD></TR>
<TR><TD></TD><TD colspan="8"><A HREF="#004">Item&nbsp;5. Interests of Named Experts and Counsel</A></TD></TR>
<TR><TD></TD><TD colspan="8"><A HREF="#005">Item&nbsp;6. Indemnification of Directors and Officers</A></TD></TR>
<TR><TD></TD><TD colspan="8"><A HREF="#006">Item&nbsp;7. Exemption from Registration Claimed</A></TD></TR>
<TR><TD></TD><TD colspan="8"><A HREF="#007">Item&nbsp;8. Exhibits</A></TD></TR>
<TR><TD></TD><TD colspan="8"><A HREF="#008">Item&nbsp;9. Undertakings</A></TD></TR>
<TR><TD colspan="9"><A HREF="#009"> SIGNATURES</A></TD></TR>
<TR><TD colspan="9"><A HREF="#010"> INDEX TO EXHIBITS</A></TD></TR>
<TR><TD colspan="9"><A HREF="o17171exv5w1.htm">Consent of McCarthy Tetrault LLP</A></TD></TR>
<TR><TD colspan="9"><A HREF="o17171exv23w1.htm">Consent of Ernst & Young LLP</A></TD></TR>
<TR><TD colspan="9"><A HREF="o17171exv99w1.htm">Amended 2001 Incentive Stock Option Plan</A></TD></TR>
</TABLE>
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<!-- link1 " PART I. INFORMATION REQUIRED IN THE SECTION 10(a) PROSPECTUS" -->
<DIV align="left"><A NAME="000"></A></DIV>

<P align="center" style="font-size: 10pt"><B>PART I. INFORMATION REQUIRED IN THE SECTION 10(a) PROSPECTUS</B>



<P align="left" style="font-size: 10pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;In accordance with Rule&nbsp;428 under the Securities Act, and the instructional Note to Part&nbsp;I of
Form S-8, the information required by Part&nbsp;I to be contained in the Section 10(a) prospectus has
been omitted from this Registration Statement. Cardiome Pharma Corp. will send or give documents
containing the information specified by Part&nbsp;I of this Registration Statement to participants in
the plan to which this Registration Statement relates, as specified in Rule&nbsp;428(b)(i) under the
Securities Act.

<!-- link1 " PART II. INFORMATION REQUIRED IN THE REGISTRATION STATEMENT" -->
<DIV align="left"><A NAME="001"></A></DIV>

<P align="center" style="font-size: 10pt"><B>PART II. INFORMATION REQUIRED IN THE REGISTRATION STATEMENT</B>


<!-- link2 "Item&nbsp;3. Incorporation of Documents by Reference" -->
<DIV align="left"><A NAME="002"></A></DIV>

<P align="left" style="font-size: 10pt"><B>Item&nbsp;3. Incorporation of Documents by Reference.</B>



<P align="left" style="margin-left: 0%; text-indent: 0%; margin-right: 0%; font-size: 10pt">The following documents heretofore filed with the Securities and Exchange Commission (the
&#147;Commission&#148;) by Cardiome Pharma Corp. (the &#147;Company&#148;) are incorporated herein by reference:



<P align="left" style="margin-left:3%; font-size: 10pt">(a)&nbsp;The Company&#146;s Annual Report on Form 40-F for the fiscal year ended December&nbsp;31, 2004.



<P align="left" style="margin-left:3%; font-size: 10pt">(b)&nbsp;The Company&#146;s reports on Form 6-K dated February&nbsp;18, 2005, March&nbsp;3, 2005, March&nbsp;23,
2005, March&nbsp;31, 2005, April&nbsp;8, 2005 and May&nbsp;13, 2005.



<P align="left" style="margin-left:3%; font-size: 10pt">(c)&nbsp;The description of the Company&#146;s Common Stock contained in the Registration Statement on
Form 20-F filed with the Commission in August&nbsp;1997 including any amendments or reports filed
for the purpose of updating such description.


<P align="left" style="margin-left: 0%; text-indent: 0%; margin-right: 0%; font-size: 10pt">All documents subsequently filed by the Company with the Commission pursuant to Sections&nbsp;13(a),
13(c), 14 and 15(d) of the Exchange Act, prior to the filing of a post-effective amendment to this
Registration Statement which indicates that all securities offered hereby have been sold or which
deregisters all securities then remaining unsold, shall be deemed to be incorporated in this
Registration Statement by reference and to be a part hereof from the date of filing of such
documents, other than information in the documents that is not deemed to be filed with the
Commission.


<P align="left" style="margin-left: 0%; text-indent: 0%; margin-right: 0%; font-size: 10pt">Any statement contained herein or in a document incorporated or deemed to be incorporated by
reference herein, shall be deemed to be modified or superseded for purposes of this Registration
Statement to the extent that a statement contained in any subsequently filed document which is
incorporated by reference herein, modifies or supersedes the statement. Any statements so modified
or superseded shall not be deemed, except as so modified or superseded, to constitute a part of
this Registration Statement.

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<DIV align="left"><A NAME="003"></A></DIV>

<P align="left" style="font-size: 10pt"><B>Item&nbsp;4. Description of Securities.</B>



<P align="left" style="font-size: 10pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Not Applicable.

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<DIV align="left"><A NAME="004"></A></DIV>

<P align="left" style="font-size: 10pt"><B>Item&nbsp;5. Interests of Named Experts and Counsel.</B>



<P align="left" style="font-size: 10pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Not Applicable.


<P align="center" style="font-size: 10pt">&nbsp;
</DIV>

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<DIV style="font-family: 'Times New Roman',Times,serif">
<!-- link2 "Item&nbsp;6. Indemnification of Directors and Officers" -->
<DIV align="left"><A NAME="005"></A></DIV>

<P align="left" style="font-size: 10pt"><B>Item&nbsp;6. Indemnification of Directors and Officers.</B>



<P align="left" style="margin-left: 0%; text-indent: 0%; margin-right: 0%; font-size: 10pt">Directors and officers of Cardiome Pharma Corp. are entitled to indemnification in the following
circumstances:


<P align="left" style="margin-left: 0%; text-indent: 0%; margin-right: 0%; font-size: 10pt">(a)&nbsp;Under the Canada Business Corporations Act, a corporation may indemnify a director or officer
of the corporation, a former director or officer of the corporation or another individual who acts
or acted at the corporation&#146;s request as a director or officer, or an individual acting in a
similar capacity, of another entity, against all costs, charges and expenses, including an amount
paid to settle an action or satisfy a judgment, reasonably incurred by the individual in respect of
any civil, criminal, administrative, investigative or other proceeding in which the individual is
involved because of that association with the corporation or other entity. A corporation may not
indemnify an individual unless the individual (i)&nbsp;acted honestly and in good faith with a view to
the best interests of the corporation or, as the case may be, in the best interests of the other
entity for which the individual acted as a director or officer in a similar capacity at the
corporation&#146;s request and (ii)&nbsp;in the case of a criminal or administrative action or proceeding
that is enforced by a monetary penalty, had reasonable grounds for believing that his or her
conduct was lawful. Such indemnification may be made in connection with an action by or on behalf
of the corporation or other entity to procure a judgment in its favour only with court approval. A
director or officer is entitled to indemnification from the corporation as a matter of right if he
or she was not judged by the court or other competent authority to have committed any fault or
omitted to do anything that he or she ought to have done and fulfilled the conditions set forth
above. The corporation may advance moneys to a director, officer or other individual for the costs,
charges and expenses of a proceeding referred to above. The individual shall repay the moneys if he
or she does not fulfill the conditions set forth above to qualify for indemnification.


<P align="left" style="margin-left: 0%; text-indent: 0%; margin-right: 0%; font-size: 10pt">(b)&nbsp;The
Company&#146;s By-laws provide that it will indemnify any of its directors, former directors, officers and
former officers and other parties specified by the By-laws, against all costs, charges and
expenses, including an amount paid to settle an action or satisfy a judgment, reasonably incurred
by them for any civil, criminal or administrative action or proceeding to which they are or may be
made a party by reason of having been a director or officer.


<P align="left" style="margin-left: 0%; text-indent: 0%; margin-right: 0%; font-size: 10pt">(c)&nbsp;The
Company has entered into Indemnity Agreements with certain of its officers and directors, pursuant
to which it is obligated to indemnify and hold harmless such persons against all costs, charges
and expenses, including any amounts paid to settle actions or satisfy judgments, reasonably
incurred by them in respect of any civil, criminal, administrative, investigative or other
proceeding to which they are made a party by reason of being or having been an officer or director.
However, such indemnification obligations arise only to the extent that the party seeking
indemnification was acting honestly and in good faith with a view to
the Company&#146;s best interests, and, in
the case of criminal or administrative actions or proceedings enforced by monetary penalties, that
such person had reasonable grounds for believing that his or her conduct was lawful. Under these
Indemnity Agreements, the Company may advance to the indemnified parties the expenses incurred in defending
any such actions or proceedings, but if the director or officer does not meet the conditions to
qualify for indemnification, such amounts shall be repaid.


<P align="left" style="margin-left: 0%; text-indent: 0%; margin-right: 0%; font-size: 10pt">As
permitted by the Canada Business Corporations Act, the Company has purchased directors&#146; and officers&#146;
liability insurance which, under certain circumstances, insures its directors and officers against
the costs of defense, settlement or payment of a judgment.



<P align="center" style="font-size: 10pt">&nbsp;
</DIV>

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<DIV style="font-family: 'Times New Roman',Times,serif">



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<DIV align="left"><A NAME="006"></A></DIV>

<P align="left" style="font-size: 10pt"><B>Item&nbsp;7. Exemption from Registration Claimed.</B>



<P align="left" style="font-size: 10pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Not Applicable.

<!-- link2 "Item&nbsp;8. Exhibits" -->
<DIV align="left"><A NAME="007"></A></DIV>

<P align="left" style="font-size: 10pt"><B>Item&nbsp;8. Exhibits.</B>



<P align="left" style="font-size: 10pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;The Exhibits to this Registration Statement are listed in the Index to Exhibits on page.

<!-- link2 "Item&nbsp;9. Undertakings" -->
<DIV align="left"><A NAME="008"></A></DIV>

<P align="left" style="font-size: 10pt"><B>Item&nbsp;9. Undertakings.</B>



<P align="left" style="font-size: 10pt">(a)&nbsp;The undersigned registrant hereby undertakes:



<P align="left" style="font-size: 10pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(1)&nbsp;To file, during any period in which offers or sales are being made, a post-effective
amendment to this Registration Statement:



<P align="left" style="margin-left:3%; font-size: 10pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(i) To include any prospectus required by Section&nbsp;10(a)(3) of the Securities Act;



<P align="left" style="margin-left:3%; font-size: 10pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(ii) To reflect in the prospectus any facts or events arising after the effective date
of the Registration Statement (or the most recent post-effective amendment thereof) which,
individually or in the aggregate, represent a fundamental change in the information set
forth in the Registration Statement. Notwithstanding the foregoing, any increase or
decrease in volume of securities offered (if the total dollar value of securities offered
would not exceed that which was registered) and any deviation from the low or high end of
the estimated maximum offering range may be reflected in the form of prospectus filed with
the Commission pursuant to Rule 424(b) if, in the aggregate, the changes in volume and price
represent no more than 20&nbsp;percent change in the maximum aggregate offering price set forth
in the &#147;Calculation of Registration Fee&#148; table in the effective registration statement;



<P align="left" style="margin-left:3%; font-size: 10pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(iii) To include any material information with respect to the plan of distribution not
previously disclosed in the Registration Statement or any material change to that
information in the Registration Statement;


<P align="left" style="font-size: 10pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;provided, however, that clauses (i)&nbsp;and (ii)&nbsp;above do not apply if the information required to
be included in a post-effective amendment by such clauses is contained in periodic reports filed
with or furnished to Commission by the registrant pursuant to Section&nbsp;13 or Sections 15(d) of the
Exchange Act that are incorporated by reference in the Registration Statement.


<P align="left" style="font-size: 10pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(2)&nbsp;That, for the purpose of determining any liability under the Securities Act, each such
post-effective amendment shall be deemed to be a new registration statement relating to the
securities offered therein, and the offering of such securities at that time shall be deemed to be
the initial bona fide offering thereof.


<P align="left" style="font-size: 10pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(3)&nbsp;To remove from registration by means of a post-effective amendment any of the securities
being registered that remain unsold at the termination of the offering.


<P align="left" style="margin-left: 0%; text-indent: 0%; margin-right: 0%; font-size: 10pt">(b)&nbsp;That, for purposes of determining any liability under the Securities Act, each filing of the
registrant&#146;s annual report pursuant to Section 13(a) or Section 15(d) of the Exchange Act that is
incorporated by reference in this Registration Statement shall be deemed to be a new registration
statement relating to the





<P align="center" style="font-size: 10pt">&nbsp;
</DIV>

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<H5 align="left" style="page-break-before:always">&nbsp;</H5><P>

<DIV style="font-family: 'Times New Roman',Times,serif">




<P align="left" style="margin-left: 0%; text-indent: 0%; margin-right: 0%; font-size: 10pt">securities offered therein, and the offering of such securities at that time shall be deemed to be
the initial bona fide offering thereof.


<P align="left" style="margin-left: 0%; text-indent: 0%; margin-right: 0%; font-size: 10pt">(c)&nbsp;Insofar as indemnification for liabilities arising under the Securities Act may be permitted
to directors, officers and controlling persons of the registrant pursuant to the foregoing
provisions, or otherwise, the registrant has been advised that in the opinion of the Commission
such indemnification is against public policy as expressed in the Securities Act and is, therefore,
unenforceable. In the event that a claim for indemnification against such liabilities (other than
the payment by the registrant of expenses incurred or paid by a director, officer or controlling
person of the registrant in the successful defense of any action, suit or proceeding) is asserted
by such director, officer or controlling person in connection with the securities being registered,
the registrant will, unless in the opinion of its counsel the matter has been settled by
controlling precedent, submit to a court of appropriate jurisdiction the question whether such
indemnification by it is against public policy as expressed in the Securities Act and will be
governed by the final adjudication of such issue.




<P align="center" style="font-size: 10pt">&nbsp;
</DIV>

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<H5 align="left" style="page-break-before:always">&nbsp;</H5><P>

<DIV style="font-family: 'Times New Roman',Times,serif">



<!-- link1 " SIGNATURES" -->
<DIV align="left"><A NAME="009"></A></DIV>

<P align="center" style="font-size: 10pt"><B>SIGNATURES</B>



<P align="left" style="font-size: 10pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Pursuant to the requirements of the Securities Act of 1933 the registrant certifies that
it has reasonable grounds to believe that it meets all of the requirements for filing on Form S-8
and has duly caused this its Registration Statement to be signed on its behalf by the undersigned,
thereunto duly authorized, in the City of Vancouver, Province of
British Columbia, on the 16th&nbsp;day
of June, 2005.

<DIV align="center">
<TABLE style="font-size: 10pt" cellspacing="0" border="0" cellpadding="0" width="100%">
<!-- Begin Table Head -->
<TR valign="bottom">
    <TD width="48%">&nbsp;</TD>
    <TD width="2%">&nbsp;</TD>
    <TD width="2%">&nbsp;</TD>
    <TD width="2%">&nbsp;</TD>
    <TD width="50%">&nbsp;</TD>
</TR>

<!-- End Table Head -->
<!-- Begin Table Body -->
<TR valign="bottom">
    <TD valign="top">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD colspan="3" valign="top" align="left">CARDIOME PHARMA CORP.</TD>
</TR>
<TR valign="bottom">
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">&nbsp;</TD>
</TR>
<TR valign="bottom">
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">By:</TD>
    <TD>&nbsp;</TD>

<TD align="left" valign="top"><DIV align="left"><DIV style="font-size: 10pt; margin-top: 0pt; width: 65%; border-BOTTOM: 1px solid #000000">/s/&nbsp;&nbsp;&nbsp;
ROBERT W. RIEDER</DIV></DIV></TD>
</TR>


<TR valign="bottom">
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;
</DIV></TD>

    <TD>&nbsp;</TD>
    <TD align="left" valign="top">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">&nbsp;&nbsp;&nbsp;&nbsp;Robert W. Rieder</TD>
</TR>
<TR valign="bottom">
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<I>President and Chief Executive Officer</I></TD>
</TR>
<!-- End Table Body -->
</TABLE>
</DIV>


<P align="center" style="font-size: 10pt"><B>POWER OF ATTORNEY</B>



<P align="left" style="font-size: 10pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;KNOW ALL PERSONS BY THESE PRESENTS, that each person whose signature appears below constitutes
and appoints Robert W. Rieder and Douglas G. Janzen, jointly and severally, each in his own
capacity, his true and lawful attorneys-in-fact, with full power of substitution, for him and his
name, place and stead, in any and all capacities, to sign any and all amendments (including
post-effective amendments) to this registration statement, and to file the same, with all exhibits
thereto and other documents in connection therewith, with the Securities and Exchange Commission,
granting unto such said attorneys-in-fact and agents with full power and authority to do so and
perform each and every act and thing requisite and necessary to be done in and about the premises,
as fully to all intents and purposes as he might or could do in person, hereby ratifying and
confirming all that said attorneys-in-fact, or their substitute or substitutes, may lawfully do or
cause to be done by virtue hereof.


<P align="left" style="font-size: 10pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Pursuant to the requirements of the Securities Act of 1933, this Registration Statement on
Form S-8 has been signed by the following persons in the capacities
indicated on June&nbsp;16, 2005.

<DIV align="center">
<TABLE style="font-size: 10pt" cellspacing="0" border="0" cellpadding="0" width="100%">
<!-- Begin Table Head -->
<TR valign="bottom">
    <TD width="48%">&nbsp;</TD>
    <TD width="2%">&nbsp;</TD>
    <TD width="50%">&nbsp;</TD>
</TR>
<TR style="font-size: 8pt" valign="bottom">
    <TD nowrap align="center" style="border-bottom: 1px solid #000000"><B>Signature</B></TD>
    <TD>&nbsp;</TD>
    <TD nowrap align="center" style="border-bottom: 1px solid #000000"><B>Title</B></TD>
</TR>
<TR>
<TD>&nbsp;</TD>
</TR>

<!-- End Table Head -->
<!-- Begin Table Body -->
<TR valign="bottom">
    <TD align="center" valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="center" valign="top">&nbsp;</TD>
</TR>
<TR valign="bottom">
    <TD align="center" valign="top">/s/&nbsp;&nbsp;&nbsp;ROBERT W. RIEDER<DIV style="margin-left:0px; text-indent:-0px"><HR size="1" noshade color="#000000">
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="center" valign="bottom">President and Chief Executive Officer, Director</TD>
</TR>
<TR valign="bottom">
    <TD align="center" valign="top"><DIV style="margin-left:0px; text-indent:-0px">Robert W. Rieder
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="center" valign="top">(Principal Executive Officer)</TD>
</TR>
<TR valign="bottom">
    <TD align="center" valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="center" valign="top">&nbsp;</TD>
</TR>
<TR valign="bottom">
    <TD align="center" valign="top">/s/&nbsp;&nbsp;&nbsp;DOUGLAS G. JANZEN<DIV style="margin-left:0px; text-indent:-0px"><HR size="1" noshade color="#000000">
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="center" valign="bottom">Chief Financial Officer</TD>
</TR>
<TR valign="bottom">
    <TD align="center" valign="top"><DIV style="margin-left:0px; text-indent:-0px">Douglas G. Janzen
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="center" valign="top">(Principal Financial Officer)</TD>
</TR>
<TR valign="bottom">
    <TD align="center" valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="center" valign="top">&nbsp;</TD>
</TR>
<TR valign="bottom">
    <TD align="center" valign="top">/s/&nbsp;&nbsp;&nbsp;MARK C. ROGERS<DIV style="margin-left:0px; text-indent:-0px"><HR size="1" noshade color="#000000">
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="center" valign="top">Chairman of the Board of Directors</TD>
</TR>
<TR valign="bottom">
    <TD align="center" valign="top"><DIV style="margin-left:0px; text-indent:-0px">Mark C. Rogers
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="center" valign="top">&nbsp;</TD>
</TR>
<TR valign="bottom">
    <TD align="center" valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="center" valign="top">&nbsp;</TD>
</TR>
<TR valign="bottom">
    <TD align="center" valign="top">/s/&nbsp;&nbsp;&nbsp;FRED H. MERMELSTEIN<DIV style="margin-left:0px; text-indent:-0px"><HR size="1" noshade color="#000000">
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="center" valign="top">Director</TD>
</TR>
<TR valign="bottom">
    <TD align="center" valign="top"><DIV style="margin-left:0px; text-indent:-0px">Fred H. Mermelstein</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="center" valign="top">&nbsp;</TD>
</TR>
<TR valign="bottom">
    <TD align="center" valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="center" valign="top">&nbsp;</TD>
</TR>
<TR valign="bottom">
    <TD align="center" valign="top">/s/&nbsp;&nbsp;&nbsp;RALPH SNYDERMAN<DIV style="margin-left:0px; text-indent:-0px"><HR size="1" noshade color="#000000">
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="center" valign="top">Director</TD>
</TR>
<TR valign="bottom">
    <TD align="center" valign="top"><DIV style="margin-left:0px; text-indent:-0px">Ralph Snyderman</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="center" valign="top">&nbsp;</TD>
</TR>
<TR valign="bottom">
    <TD align="center" valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="center" valign="top">&nbsp;</TD>
</TR>
<TR valign="bottom">
    <TD align="center" valign="top">/s/&nbsp;&nbsp;&nbsp;JACKIE M. CLEGG<DIV style="margin-left:0px; text-indent:-0px"><HR size="1" noshade color="#000000">
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="center" valign="top">Director</TD>
</TR>
<TR valign="bottom">
    <TD align="center" valign="top"><DIV style="margin-left:0px; text-indent:-0px">Jackie M. Clegg</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="center" valign="top">&nbsp;</TD>
</TR>
<TR valign="bottom">
    <TD align="center" valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="center" valign="top">&nbsp;</TD>
</TR>
<TR valign="bottom">
    <TD align="center" valign="top">/s/&nbsp;&nbsp;&nbsp;HAROLD H. SHLEVIN<DIV style="margin-left:0px; text-indent:-0px"><HR size="1" noshade color="#000000">
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="center" valign="top">Director</TD>
</TR>
<TR valign="bottom">
    <TD align="center" valign="top"><DIV style="margin-left:0px; text-indent:-0px">Harold H. Shlevin</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="center" valign="top">&nbsp;</TD>
</TR>
<!-- End Table Body -->
</TABLE>
</DIV>


<P align="center" style="font-size: 10pt">&nbsp;
</DIV>

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<H5 align="left" style="page-break-before:always">&nbsp;</H5><P>

<DIV style="font-family: 'Times New Roman',Times,serif">


<P align="center" style="font-size: 10pt"><B>AUTHORIZED REPRESENTATIVE IN THE UNITED STATES</B>



<P align="left" style="font-size: 10pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Pursuant to the requirements of Section 6(a) of the Securities Act of 1933, the
undersigned has signed this registration statement, solely in the capacity of the duly authorized
representative of the registrant in the United States, in the City of
Miami, Florida, on the 16th&nbsp;day of June, 2005.

<DIV align="center">
<TABLE style="font-size: 10pt" cellspacing="0" border="0" cellpadding="0" width="100%">
<!-- Begin Table Head -->
<TR valign="bottom">
    <TD width="50%">&nbsp;</TD>
    <TD width="3%">&nbsp;</TD>
    <TD width="2%">&nbsp;</TD>
    <TD width="1%">&nbsp;</TD>
    <TD width="44%">&nbsp;</TD>
</TR>

<!-- End Table Head -->
<!-- Begin Table Body -->
<TR valign="bottom">
    <TD valign="top">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD colspan="3" valign="top" align="left">CARDIOME, INC.</TD>
</TR>
<TR valign="bottom">
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">&nbsp;</TD>
</TR>
<TR valign="bottom">
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">By:</TD>
    <TD>&nbsp;</TD>

<TD align="left" valign="top"><DIV align="left"><DIV style="font-size: 10pt; margin-top: 0pt; width: 60%; border-bottom: 1px solid #000000">/s/&nbsp;&nbsp;&nbsp;ALAN
M. EZRIN</DIV></DIV></TD>
</TR>

<TR valign="bottom">
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">Alan M. Ezrin, President</TD>
</TR>
<!-- End Table Body -->
</TABLE>
</DIV>


<P align="center" style="font-size: 10pt">&nbsp;
</DIV>

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<H5 align="left" style="page-break-before:always">&nbsp;</H5><P>

<DIV style="font-family: 'Times New Roman',Times,serif">

<!-- link1 " INDEX TO EXHIBITS " -->
<DIV align="left"><A NAME="010"></A></DIV>

<P align="center" style="font-size: 10pt"><B>INDEX TO EXHIBITS</B>


<DIV align="center">
<TABLE style="font-size: 10pt" cellspacing="0" border="0" cellpadding="0" width="100%">
<!-- Begin Table Head -->
<TR valign="bottom">
    <TD width="8%">&nbsp;</TD>
    <TD width="2%">&nbsp;</TD>
    <TD width="90%">&nbsp;</TD>
</TR>
<TR style="font-size: 8pt" valign="bottom">
    <TD nowrap align="center" style="border-bottom: 1px solid #000000">Exhibit Number</TD>
    <TD>&nbsp;</TD>
    <TD nowrap align="center" style="border-bottom: 1px solid #000000">Description</TD>
</TR>

<!-- End Table Head -->
<!-- Begin Table Body -->
<TR valign="bottom">
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">5.1
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">Opinion of McCarthy T&#233;trault LLP</TD>
</TR>
<TR valign="bottom">
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">&nbsp;</TD>
</TR>
<TR valign="bottom">
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">23.1
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">Consent of Ernst &#038; Young LLP, Independent Registered Public
Accounting Firm</TD>
</TR>
<TR valign="bottom">
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">&nbsp;</TD>
</TR>
<TR valign="bottom">
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">23.2
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">Consent of McCarthy T&#233;trault LLP (included in Exhibit&nbsp;5.1)</TD>
</TR>
<TR valign="bottom">
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">&nbsp;</TD>
</TR>
<TR valign="bottom">
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">24.1

</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">Power of Attorney (included as part of the signature page to
this Registration Statement and incorporated hereby
reference)</TD>
</TR>
<TR valign="bottom">
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">&nbsp;</TD>
</TR>
<TR valign="bottom">
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">99.1
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">Cardiome Pharma Corp. Amended 2001 Incentive Stock Option Plan</TD>
</TR>
<!-- End Table Body -->
</TABLE>
</DIV>


<P align="center" style="font-size: 10pt">&nbsp;
</DIV>

</BODY>
</HTML>
[{"type": "S-8", "sequence": "1", "filename": "o17171sv8.htm", "description": "FORM S-8", "secsgml_size_bytes": 43212}]
{"company-data": {"conformed-name": "Cardiome Pharma Corp", "cik": "0001036141", "assigned-sic": "2834", "irs-number": "000000000", "state-of-incorporation": "A1", "fiscal-year-end": "1130"}, "filing-values": {"form-type": "S-8", "act": "33", "file-number": "333-125860", "film-number": "05900248"}, "business-address": {"street1": "6190 AGRONOMY RD. 6TH FLOOR", "city": "VANCOUVER", "state": "A1", "zip": "V6T 1Z3", "phone": "1-604-677-6905"}, "mail-address": {"street1": "6190 AGRONOMY RD. 6TH FLOOR", "city": "VANCOUVER", "state": "A1", "zip": "V6T 1Z3"}, "former-company": {"former-conformed-name": "CARDIOME PHARMA CORP", "date-changed": "20000407"}}
Form S-8
As filed with the
Securities and Exchange Commission on June 16, 2005
SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM S-8
REGISTRATION STATEMENT
UNDER
THE SECURITIES ACT OF 1933
CARDIOME PHARMA CORP.
(Exact name of registrant as specified in its charter)
Canada
(State or other jurisdiction of
incorporation or organization)
Not Applicable
(IRS Employer
Identification No.)
6th Floor, 6190 Agronomy Road
Vancouver, British Columbia
Canada V6T 1Z3
(604) 667-6905
(Address of registrant's Principal Executive Offices)
AMENDED 2001 INCENTIVE STOCK OPTION PLAN
(Full title of the plan)
PTSGE Corp.
925 Fourth Avenue, Suite 2900
Seattle, Washington 98104
(206) 623-7580
(Name, address, including ZIP code, and telephone number, including area code, of agent for service)
Copies to:
Annette Elinger Becker, Esq.
Devin W. Stockfish, Esq.
Preston Gates & Ellis LLP
925 Fourth Avenue, Suite 2900
Seattle, WA 98104
(206) 623-7580
CALCULATION OF REGISTRATION FEE
Proposed maximum
Proposed maximum
Title of each class of
Amount to be
offering price per
aggregate offering
Amount of
securities to be registered
registered (1)(2)
share
price (2)
registration fee
Common Shares, without
par value
4,990,068 shares (3)
$4.01 (4)
$20,010,172.68
$2,355.20
Common Shares, without
par value
759,932 shares (5)
$5.62 (6)
$4,270,817.84
$502.68
TOTAL
5,750,000 shares
$24,280,990.52
$2,857.87
(1)
Pursuant to Rule 416(a) under the Securities Act of 1933, as amended (the "Securities Act"),
this Registration Statement shall also cover any additional Common Shares that become issuable
under the Amended 2001 Incentive Stock Option Plan (the "Plan") by reason of any stock
dividend, stock split, recapitalization or other similar transaction effected without receipt
of consideration that increases the number of the registrant's outstanding Common Shares.
(2)
For the sole purpose of calculation of the registration fee, the number of shares to be
registered under this Registration Statement has been broken down into two subtotals.
(3)
This subtotal represents the aggregate number of shares issuable upon exercise of presently
outstanding options issued under the Plan.
(4)
Computed in accordance with Rule 457(h) under the Securities Act, solely for the purpose of
calculating the registration fee, based on the weighted average exercise price (rounded to the
nearest cent and converted at the exchange rate posted on June 3, 2005) for outstanding
options granted pursuant to the Plan.
(5)
This subtotal represents the aggregate number of shares reserved for future option grants
under the Plan.
(6)
Computed in accordance with Rule 457(h) and Rule 457(c) under the Securities Act, solely for
the purpose of calculating the registration fee, based on the average of the high and low
prices of the Common Shares as reported by The Nasdaq Stock Market on June 10, 2005.
TABLE OF CONTENTS
PART I. INFORMATION REQUIRED IN THE SECTION 10(a) PROSPECTUS
PART II. INFORMATION REQUIRED IN THE REGISTRATION STATEMENT
Item 3. Incorporation of Documents by Reference
Item 4. Description of Securities
Item 5. Interests of Named Experts and Counsel
Item 6. Indemnification of Directors and Officers
Item 7. Exemption from Registration Claimed
Item 8. Exhibits
Item 9. Undertakings
SIGNATURES
INDEX TO EXHIBITS
Consent of McCarthy Tetrault LLP
Consent of Ernst & Young LLP
Amended 2001 Incentive Stock Option Plan
PART I. INFORMATION REQUIRED IN THE SECTION 10(a) PROSPECTUS
In accordance with Rule 428 under the Securities Act, and the instructional Note to Part I of
Form S-8, the information required by Part I to be contained in the Section 10(a) prospectus has
been omitted from this Registration Statement. Cardiome Pharma Corp. will send or give documents
containing the information specified by Part I of this Registration Statement to participants in
the plan to which this Registration Statement relates, as specified in Rule 428(b)(i) under the
Securities Act.
PART II. INFORMATION REQUIRED IN THE REGISTRATION STATEMENT
Item 3. Incorporation of Documents by Reference.
The following documents heretofore filed with the Securities and Exchange Commission (the
"Commission") by Cardiome Pharma Corp. (the "Company") are incorporated herein by reference:
(a) The Company's Annual Report on Form 40-F for the fiscal year ended December 31, 2004.
(b) The Company's reports on Form 6-K dated February 18, 2005, March 3, 2005, March 23,
2005, March 31, 2005, April 8, 2005 and May 13, 2005.
(c) The description of the Company's Common Stock contained in the Registration Statement on
Form 20-F filed with the Commission in August 1997 including any amendments or reports filed
for the purpose of updating such description.
All documents subsequently filed by the Company with the Commission pursuant to Sections 13(a),
13(c), 14 and 15(d) of the Exchange Act, prior to the filing of a post-effective amendment to this
Registration Statement which indicates that all securities offered hereby have been sold or which
deregisters all securities then remaining unsold, shall be deemed to be incorporated in this
Registration Statement by reference and to be a part hereof from the date of filing of such
documents, other than information in the documents that is not deemed to be filed with the
Commission.
Any statement contained herein or in a document incorporated or deemed to be incorporated by
reference herein, shall be deemed to be modified or superseded for purposes of this Registration
Statement to the extent that a statement contained in any subsequently filed document which is
incorporated by reference herein, modifies or supersedes the statement. Any statements so modified
or superseded shall not be deemed, except as so modified or superseded, to constitute a part of
this Registration Statement.
Item 4. Description of Securities.
Not Applicable.
Item 5. Interests of Named Experts and Counsel.
Not Applicable.
Item 6. Indemnification of Directors and Officers.
Directors and officers of Cardiome Pharma Corp. are entitled to indemnification in the following
circumstances:
(a) Under the Canada Business Corporations Act, a corporation may indemnify a director or officer
of the corporation, a former director or officer of the corporation or another individual who acts
or acted at the corporation's request as a director or officer, or an individual acting in a
similar capacity, of another entity, against all costs, charges and expenses, including an amount
paid to settle an action or satisfy a judgment, reasonably incurred by the individual in respect of
any civil, criminal, administrative, investigative or other proceeding in which the individual is
involved because of that association with the corporation or other entity. A corporation may not
indemnify an individual unless the individual (i) acted honestly and in good faith with a view to
the best interests of the corporation or, as the case may be, in the best interests of the other
entity for which the individual acted as a director or officer in a similar capacity at the
corporation's request and (ii) in the case of a criminal or administrative action or proceeding
that is enforced by a monetary penalty, had reasonable grounds for believing that his or her
conduct was lawful. Such indemnification may be made in connection with an action by or on behalf
of the corporation or other entity to procure a judgment in its favour only with court approval. A
director or officer is entitled to indemnification from the corporation as a matter of right if he
or she was not judged by the court or other competent authority to have committed any fault or
omitted to do anything that he or she ought to have done and fulfilled the conditions set forth
above. The corporation may advance moneys to a director, officer or other individual for the costs,
charges and expenses of a proceeding referred to above. The individual shall repay the moneys if he
or she does not fulfill the conditions set forth above to qualify for indemnification.
(b) The
Company's By-laws provide that it will indemnify any of its directors, former directors, officers and
former officers and other parties specified by the By-laws, against all costs, charges and
expenses, including an amount paid to settle an action or satisfy a judgment, reasonably incurred
by them for any civil, criminal or administrative action or proceeding to which they are or may be
made a party by reason of having been a director or officer.
(c) The
Company has entered into Indemnity Agreements with certain of its officers and directors, pursuant
to which it is obligated to indemnify and hold harmless such persons against all costs, charges
and expenses, including any amounts paid to settle actions or satisfy judgments, reasonably
incurred by them in respect of any civil, criminal, administrative, investigative or other
proceeding to which they are made a party by reason of being or having been an officer or director.
However, such indemnification obligations arise only to the extent that the party seeking
indemnification was acting honestly and in good faith with a view to
the Company's best interests, and, in
the case of criminal or administrative actions or proceedings enforced by monetary penalties, that
such person had reasonable grounds for believing that his or her conduct was lawful. Under these
Indemnity Agreements, the Company may advance to the indemnified parties the expenses incurred in defending
any such actions or proceedings, but if the director or officer does not meet the conditions to
qualify for indemnification, such amounts shall be repaid.
As
permitted by the Canada Business Corporations Act, the Company has purchased directors' and officers'
liability insurance which, under certain circumstances, insures its directors and officers against
the costs of defense, settlement or payment of a judgment.
Item 7. Exemption from Registration Claimed.
Not Applicable.
Item 8. Exhibits.
The Exhibits to this Registration Statement are listed in the Index to Exhibits on page.
Item 9. Undertakings.
(a) The undersigned registrant hereby undertakes:
(1) To file, during any period in which offers or sales are being made, a post-effective
amendment to this Registration Statement:
(i) To include any prospectus required by Section 10(a)(3) of the Securities Act;
(ii) To reflect in the prospectus any facts or events arising after the effective date
of the Registration Statement (or the most recent post-effective amendment thereof) which,
individually or in the aggregate, represent a fundamental change in the information set
forth in the Registration Statement. Notwithstanding the foregoing, any increase or
decrease in volume of securities offered (if the total dollar value of securities offered
would not exceed that which was registered) and any deviation from the low or high end of
the estimated maximum offering range may be reflected in the form of prospectus filed with
the Commission pursuant to Rule 424(b) if, in the aggregate, the changes in volume and price
represent no more than 20 percent change in the maximum aggregate offering price set forth
in the "Calculation of Registration Fee" table in the effective registration statement;
(iii) To include any material information with respect to the plan of distribution not
previously disclosed in the Registration Statement or any material change to that
information in the Registration Statement;
provided, however, that clauses (i) and (ii) above do not apply if the information required to
be included in a post-effective amendment by such clauses is contained in periodic reports filed
with or furnished to Commission by the registrant pursuant to Section 13 or Sections 15(d) of the
Exchange Act that are incorporated by reference in the Registration Statement.
(2) That, for the purpose of determining any liability under the Securities Act, each such
post-effective amendment shall be deemed to be a new registration statement relating to the
securities offered therein, and the offering of such securities at that time shall be deemed to be
the initial bona fide offering thereof.
(3) To remove from registration by means of a post-effective amendment any of the securities
being registered that remain unsold at the termination of the offering.
(b) That, for purposes of determining any liability under the Securities Act, each filing of the
registrant's annual report pursuant to Section 13(a) or Section 15(d) of the Exchange Act that is
incorporated by reference in this Registration Statement shall be deemed to be a new registration
statement relating to the
securities offered therein, and the offering of such securities at that time shall be deemed to be
the initial bona fide offering thereof.
(c) Insofar as indemnification for liabilities arising under the Securities Act may be permitted
to directors, officers and controlling persons of the registrant pursuant to the foregoing
provisions, or otherwise, the registrant has been advised that in the opinion of the Commission
such indemnification is against public policy as expressed in the Securities Act and is, therefore,
unenforceable. In the event that a claim for indemnification against such liabilities (other than
the payment by the registrant of expenses incurred or paid by a director, officer or controlling
person of the registrant in the successful defense of any action, suit or proceeding) is asserted
by such director, officer or controlling person in connection with the securities being registered,
the registrant will, unless in the opinion of its counsel the matter has been settled by
controlling precedent, submit to a court of appropriate jurisdiction the question whether such
indemnification by it is against public policy as expressed in the Securities Act and will be
governed by the final adjudication of such issue.
SIGNATURES
Pursuant to the requirements of the Securities Act of 1933 the registrant certifies that
it has reasonable grounds to believe that it meets all of the requirements for filing on Form S-8
and has duly caused this its Registration Statement to be signed on its behalf by the undersigned,
thereunto duly authorized, in the City of Vancouver, Province of
British Columbia, on the 16th day
of June, 2005.
CARDIOME PHARMA CORP.
By:
/s/   
ROBERT W. RIEDER
Robert W. Rieder
President and Chief Executive Officer
POWER OF ATTORNEY
KNOW ALL PERSONS BY THESE PRESENTS, that each person whose signature appears below constitutes
and appoints Robert W. Rieder and Douglas G. Janzen, jointly and severally, each in his own
capacity, his true and lawful attorneys-in-fact, with full power of substitution, for him and his
name, place and stead, in any and all capacities, to sign any and all amendments (including
post-effective amendments) to this registration statement, and to file the same, with all exhibits
thereto and other documents in connection therewith, with the Securities and Exchange Commission,
granting unto such said attorneys-in-fact and agents with full power and authority to do so and
perform each and every act and thing requisite and necessary to be done in and about the premises,
as fully to all intents and purposes as he might or could do in person, hereby ratifying and
confirming all that said attorneys-in-fact, or their substitute or substitutes, may lawfully do or
cause to be done by virtue hereof.
Pursuant to the requirements of the Securities Act of 1933, this Registration Statement on
Form S-8 has been signed by the following persons in the capacities
indicated on June 16, 2005.
Signature
Title
/s/   ROBERT W. RIEDER
President and Chief Executive Officer, Director
Robert W. Rieder
(Principal Executive Officer)
/s/   DOUGLAS G. JANZEN
Chief Financial Officer
Douglas G. Janzen
(Principal Financial Officer)
/s/   MARK C. ROGERS
Chairman of the Board of Directors
Mark C. Rogers
/s/   FRED H. MERMELSTEIN
Director
Fred H. Mermelstein
/s/   RALPH SNYDERMAN
Director
Ralph Snyderman
/s/   JACKIE M. CLEGG
Director
Jackie M. Clegg
/s/   HAROLD H. SHLEVIN
Director
Harold H. Shlevin
AUTHORIZED REPRESENTATIVE IN THE UNITED STATES
Pursuant to the requirements of Section 6(a) of the Securities Act of 1933, the
undersigned has signed this registration statement, solely in the capacity of the duly authorized
representative of the registrant in the United States, in the City of
Miami, Florida, on the 16th day of June, 2005.
CARDIOME, INC.
By:
/s/   ALAN
M. EZRIN
Alan M. Ezrin, President
INDEX TO EXHIBITS
Exhibit Number
Description
5.1
Opinion of McCarthy Tétrault LLP
23.1
Consent of Ernst & Young LLP, Independent Registered Public
Accounting Firm
23.2
Consent of McCarthy Tétrault LLP (included in Exhibit 5.1)
24.1
Power of Attorney (included as part of the signature page to
this Registration Statement and incorporated hereby
reference)
99.1
Cardiome Pharma Corp. Amended 2001 Incentive Stock Option Plan