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<p style="font-family:'Times New Roman', Times, serif;font-size:10pt;margin:0pt 7.2pt;text-align:center;"><b>As filed with the Securities and Exchange Commission on April 17</b><b>, 20</b><b>24</b></p>

<p style="font-family:'Times New Roman', Times, serif;font-size:10pt;margin:0pt 7.2pt;text-align:right;"><b>Registration No.&nbsp;333-</b></p>

<p style="font-size: 1pt; margin: 0pt 7.2pt; text-align: left; font-family: &quot;Times New Roman&quot;, Times, serif;">&nbsp;</p>

<p style="font-family:'Times New Roman', Times, serif;font-size:10pt;margin:0pt 7.2pt;text-align:center;">&nbsp;</p>

<p style="font-family:'Times New Roman', Times, serif;font-size:12pt;margin:0pt 7.2pt;text-align:center;"><b>UNITED STATES</b></p>

<p style="font-family:'Times New Roman', Times, serif;font-size:12pt;margin:0pt 7.2pt;text-align:center;"><b>SECURITIES AND EXCHANGE COMMISSION</b></p>

<p style="font-family:'Times New Roman', Times, serif;font-size:10pt;margin:0pt 7.2pt;text-align:center;"><b>Washington, D.C. 20549</b></p>

<p style="font-family:'Times New Roman', Times, serif;font-size:10pt;margin:0pt 7.2pt;text-align:center;">&nbsp;</p>

<p style="font-family:'Times New Roman', Times, serif;font-size:12pt;margin:0pt 7.2pt;text-align:center;"><b>FORM S-8</b></p>

<p style="font-family:'Times New Roman', Times, serif;font-size:10pt;margin:0pt 7.2pt;text-align:center;"><b>&nbsp;</b></p>

<p style="font-family:'Times New Roman', Times, serif;font-size:10pt;margin:0pt 7.2pt;text-align:center;"><b>REGISTRATION STATEMENT</b><b> </b><b>UNDER</b></p>

<p style="font-family:'Times New Roman', Times, serif;font-size:10pt;margin:0pt 7.2pt;text-align:center;"><b>THE SECURITIES ACT OF 1933</b></p>

<p style="font-family:'Times New Roman', Times, serif;font-size:10pt;margin:0pt 7.2pt;text-align:center;">&nbsp;</p>

<p style="font-family:'Times New Roman', Times, serif;font-size:12pt;margin:0pt 7.2pt;text-align:center;"><b>GENPREX, INC.</b></p>

<p style="font-family:'Times New Roman', Times, serif;font-size:10pt;margin:0pt 7.2pt;text-align:center;">(Exact name of registrant as specified in its charter)</p>

<p style="font-family:'Times New Roman', Times, serif;font-size:10pt;margin:0pt 7.2pt;text-align:center;">&nbsp;</p>

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			<td style="vertical-align:top;border-bottom:solid 1px #000000;;width:32.3%;">
			<p style="font-family:'Times New Roman', Times, serif;font-size:10pt;margin:0pt;text-align:center;"><b>Delaware</b></p>
			</td>
			<td style="vertical-align:top;width:1.9%;">
			<p style="font-family:'Times New Roman', Times, serif;font-size:10pt;margin:0pt;text-align:center;">&nbsp;</p>
			</td>
			<td style="vertical-align:top;border-bottom:solid 1px #000000;;width:32.2%;">&nbsp;</td>
			<td style="vertical-align:top;width:1.9%;">
			<p style="font-family:'Times New Roman', Times, serif;font-size:10pt;margin:0pt;text-align:center;">&nbsp;</p>
			</td>
			<td style="vertical-align:top;border-bottom:solid 1px #000000;;width:31.7%;">
			<p style="font-family:'Times New Roman', Times, serif;font-size:10pt;margin:0pt;text-align:center;"><b>90-0772347</b></p>
			</td>
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			<p style="font-family:'Times New Roman', Times, serif;font-size:10pt;margin:0pt;text-align:center;">(State&nbsp;or&nbsp;other&nbsp;jurisdiction&nbsp;of<br>
			incorporation&nbsp;or&nbsp;organization)</p>
			</td>
			<td style="vertical-align:top;width:1.9%;">
			<p style="font-family:'Times New Roman', Times, serif;font-size:10pt;margin:0pt;text-align:center;">&nbsp;</p>
			</td>
			<td style="vertical-align:top;width:32.2%;">&nbsp;</td>
			<td style="vertical-align:top;width:1.9%;">
			<p style="font-family:'Times New Roman', Times, serif;font-size:10pt;margin:0pt;text-align:center;">&nbsp;</p>
			</td>
			<td style="vertical-align:top;width:31.7%;">
			<p style="font-family:'Times New Roman', Times, serif;font-size:10pt;margin:0pt;text-align:center;">(I.R.S.&nbsp;Employer<br>
			Identification&nbsp;Number)</p>
			</td>
		</tr>

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<p style="margin: 0pt; font-family: &quot;Times New Roman&quot;, Times, serif; font-size: 10pt;">&nbsp;</p>

<p style="margin: 0pt; font-family: &quot;Times New Roman&quot;, Times, serif; font-size: 10pt;">&nbsp;</p>

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			<td style="vertical-align:top;width:32.3%;">&nbsp;</td>
			<td style="vertical-align:top;width:1.9%;">
			<p style="font-family:'Times New Roman', Times, serif;font-size:10pt;margin:0pt;text-align:center;">&nbsp;</p>
			</td>
			<td style="vertical-align:top;border-bottom:solid 1px #000000;;width:32.2%;">
			<p style="font-family:'Times New Roman', Times, serif;font-size:10pt;margin:0pt;text-align:center;"><b>3300 Bee Cave Road #650-227</b></p>

			<p style="font-family:'Times New Roman', Times, serif;font-size:10pt;margin:0pt;text-align:center;"><b>Austin, Texas 78746</b></p>
			</td>
			<td style="vertical-align:top;width:1.9%;">
			<p style="font-family:'Times New Roman', Times, serif;font-size:10pt;margin:0pt;text-align:center;">&nbsp;</p>
			</td>
			<td style="vertical-align:top;width:31.7%;">&nbsp;</td>
		</tr>
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			<td style="vertical-align:top;width:32.3%;">&nbsp;</td>
			<td style="vertical-align:top;width:1.9%;">
			<p style="font-family:'Times New Roman', Times, serif;font-size:10pt;margin:0pt;text-align:center;">&nbsp;</p>
			</td>
			<td style="vertical-align:top;width:32.2%;">
			<p style="font-family:'Times New Roman', Times, serif;font-size:10pt;margin:0pt;text-align:center;">(Address of Principal Executive Offices) (Zip Code)</p>
			</td>
			<td style="vertical-align:top;width:1.9%;">
			<p style="font-family:'Times New Roman', Times, serif;font-size:10pt;margin:0pt;text-align:center;">&nbsp;</p>
			</td>
			<td style="vertical-align:top;width:31.7%;">&nbsp;</td>
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			<td style="vertical-align:top;width:32.3%;">&nbsp;</td>
			<td style="vertical-align:top;width:1.9%;">
			<p style="font-family:'Times New Roman', Times, serif;font-size:10pt;margin:0pt;text-align:center;">&nbsp;</p>
			</td>
			<td style="vertical-align:top;border-bottom:solid 1px #000000;;width:32.2%;">
			<p style="font-family:'Times New Roman', Times, serif;font-size:10pt;margin:0pt;text-align:center;"><b>Genprex, Inc. 2018 Equity Incentive Plan</b></p>

			<p style="font-family:'Times New Roman', Times, serif;font-size:10pt;margin:0pt;text-align:center;"><b>Inducement Stock Options</b></p>
			</td>
			<td style="vertical-align:top;width:1.9%;">
			<p style="font-family:'Times New Roman', Times, serif;font-size:10pt;margin:0pt;text-align:center;">&nbsp;</p>
			</td>
			<td style="vertical-align:top;width:31.7%;">&nbsp;</td>
		</tr>
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			<td style="vertical-align:top;width:32.3%;">&nbsp;</td>
			<td style="vertical-align:top;width:1.9%;">
			<p style="font-family:'Times New Roman', Times, serif;font-size:10pt;margin:0pt;text-align:center;">&nbsp;</p>
			</td>
			<td style="vertical-align:top;width:32.2%;">
			<p style="font-family:'Times New Roman', Times, serif;font-size:10pt;margin:0pt;text-align:center;">(Full title of the plan)</p>
			</td>
			<td style="vertical-align:top;width:1.9%;">
			<p style="font-family:'Times New Roman', Times, serif;font-size:10pt;margin:0pt;text-align:center;">&nbsp;</p>
			</td>
			<td style="vertical-align:top;width:31.7%;">&nbsp;</td>
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<p style="margin: 0pt; font-family: &quot;Times New Roman&quot;, Times, serif; font-size: 10pt;">&nbsp;</p>

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			<td style="vertical-align:top;width:31.1%;">&nbsp;</td>
			<td style="vertical-align:top;width:1.7%;">
			<p style="font-family:'Times New Roman', Times, serif;font-size:10pt;margin:0pt;text-align:center;">&nbsp;</p>
			</td>
			<td style="vertical-align:top;border-bottom:solid 1px #000000;;width:35.8%;">
			<p style="font-family:'Times New Roman', Times, serif;font-size:10pt;margin:0pt;text-align:center;"><b>J. Rodney Varner</b></p>

			<p style="font-family:'Times New Roman', Times, serif;font-size:10pt;margin:0pt;text-align:center;"><b>Chief Executive Officer</b></p>

			<p style="font-family:'Times New Roman', Times, serif;font-size:10pt;margin:0pt;text-align:center;"><b>3300 Bee Cave Road #650-227</b></p>

			<p style="font-family:'Times New Roman', Times, serif;font-size:10pt;margin:0pt;text-align:center;"><b>Austin, TX 78746</b></p>
			</td>
			<td style="vertical-align:top;width:1.6%;">
			<p style="font-family:'Times New Roman', Times, serif;font-size:10pt;margin:0pt;text-align:center;">&nbsp;</p>
			</td>
			<td style="vertical-align:top;width:29.7%;">&nbsp;</td>
		</tr>
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			<td style="vertical-align:top;width:31.1%;">&nbsp;</td>
			<td style="vertical-align:top;width:1.7%;">
			<p style="font-family:'Times New Roman', Times, serif;font-size:10pt;margin:0pt;text-align:center;">&nbsp;</p>
			</td>
			<td style="vertical-align:top;width:35.8%;">
			<p style="font-family:'Times New Roman', Times, serif;font-size:10pt;margin:0pt;text-align:center;">(Name and address of agent for service)</p>
			</td>
			<td style="vertical-align:top;width:1.6%;">
			<p style="font-family:'Times New Roman', Times, serif;font-size:10pt;margin:0pt;text-align:center;">&nbsp;</p>
			</td>
			<td style="vertical-align:top;width:29.7%;">&nbsp;</td>
		</tr>

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			<td style="vertical-align:top;width:25.3%;">&nbsp;</td>
			<td style="vertical-align:top;width:1.7%;">
			<p style="font-family:'Times New Roman', Times, serif;font-size:10pt;margin:0pt;text-align:center;">&nbsp;</p>
			</td>
			<td style="vertical-align:top;border-bottom:solid 1px #000000;;width:47.5%;">
			<p style="font-family:'Times New Roman', Times, serif;font-size:10pt;margin:0pt;text-align:center;"><b>(877) 774-4679</b></p>
			</td>
			<td style="vertical-align:top;width:0.8%;">
			<p style="font-family:'Times New Roman', Times, serif;font-size:10pt;margin:0pt;text-align:center;">&nbsp;</p>
			</td>
			<td style="vertical-align:top;width:24.7%;">&nbsp;</td>
		</tr>
		<tr>
			<td style="vertical-align:top;width:25.3%;">&nbsp;</td>
			<td style="vertical-align:top;width:1.7%;">
			<p style="font-family:'Times New Roman', Times, serif;font-size:10pt;margin:0pt;text-align:center;">&nbsp;</p>
			</td>
			<td style="vertical-align:top;width:47.5%;">
			<p style="font-family:'Times New Roman', Times, serif;font-size:10pt;margin:0pt;text-align:center;">(Telephone number, including area code, of agent for service)</p>
			</td>
			<td style="vertical-align:top;width:0.8%;">
			<p style="font-family:'Times New Roman', Times, serif;font-size:10pt;margin:0pt;text-align:center;">&nbsp;</p>
			</td>
			<td style="vertical-align:top;width:24.7%;">&nbsp;</td>
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<p style="font-family:'Times New Roman', Times, serif;font-size:10pt;margin:0pt 7.2pt;text-align:center;">&nbsp;</p>

<p style="font-family:'Times New Roman', Times, serif;font-size:10pt;margin:0pt 7.2pt;text-align:center;"><i>Copies to:</i></p>

<p style="font-family:'Times New Roman', Times, serif;font-size:10pt;margin:0pt 7.2pt;text-align:center;">&nbsp;</p>

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			<p style="font-family:'Times New Roman', Times, serif;font-size:10pt;margin:0pt;text-align:center;"><b>Kate Basmagian, Esq.</b></p>

			<p style="font-family:'Times New Roman', Times, serif;font-size:10pt;margin:0pt;text-align:center;"><b>Lowenstein Sandler LLP</b></p>

			<p style="font-family:'Times New Roman', Times, serif;font-size:10pt;margin:0pt;text-align:center;"><b>1251 Avenue of the Americas</b></p>

			<p style="font-family:'Times New Roman', Times, serif;font-size:10pt;margin:0pt;text-align:center;"><b>New York, New York 10020</b></p>

			<p style="font-family:'Times New Roman', Times, serif;font-size:10pt;margin:0pt;text-align:center;"><b>Tel: (212) 262-6700</b></p>
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<p style="font-family:'Times New Roman', Times, serif;font-size:10pt;margin:0pt;text-align:left;">&nbsp;</p>

<p style="font-family: &quot;Times New Roman&quot;, Times, serif; font-size: 10pt; margin: 0pt; text-align: justify;">Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, a smaller reporting company or an emerging growth company. See the definitions of &#8220;large accelerated filer,&#8221; &#8220;accelerated filer,&#8221; &#8220;smaller reporting company,&#8221; and &#8220;emerging growth company&#8221; in Rule 12b-2 of the Exchange Act.</p>

<p style="font-family:'Times New Roman', Times, serif;font-size:10pt;margin:0pt 7.2pt;text-align:justify;">&nbsp;</p>

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			<td style="vertical-align:top;width:30.3%;">
			<p style="font-family:'Times New Roman', Times, serif;font-size:10pt;margin:0pt;text-align:left;">Large accelerated filer</p>
			</td>
			<td style="vertical-align:top;width:5.1%;">
			<p style="font-family:'Times New Roman', Times, serif;font-size:10pt;margin:0pt;text-align:left;">&#9744;</p>
			</td>
			<td style="vertical-align:top;width:29.3%;">
			<p style="font-family:'Times New Roman', Times, serif;font-size:10pt;margin:0pt;text-align:left;">&nbsp;</p>
			</td>
			<td style="vertical-align:top;width:30.3%;">
			<p style="font-family:'Times New Roman', Times, serif;font-size:10pt;margin:0pt;text-align:left;">Accelerated filer</p>
			</td>
			<td style="vertical-align:top;width:5%;">
			<p style="font-family:'Times New Roman', Times, serif;font-size:10pt;margin:0pt;text-align:left;">&#9744;</p>
			</td>
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			<td style="vertical-align:top;width:30.3%;">
			<p style="font-family:'Times New Roman', Times, serif;font-size:10pt;margin:0pt;text-align:left;">Non-accelerated filer</p>
			</td>
			<td style="vertical-align:top;width:5.1%;">
			<p style="font-family:'Times New Roman', Times, serif;font-size:10pt;margin:0pt;text-align:left;">&#9746;</p>
			</td>
			<td style="vertical-align:top;width:29.3%;">
			<p style="font-family:'Times New Roman', Times, serif;font-size:10pt;margin:0pt;text-align:left;">&nbsp;</p>
			</td>
			<td style="vertical-align:top;width:30.3%;">
			<p style="font-family:'Times New Roman', Times, serif;font-size:10pt;margin:0pt;text-align:left;">Smaller reporting company</p>
			</td>
			<td style="vertical-align:top;width:5%;">
			<p style="font-family:'Times New Roman', Times, serif;font-size:10pt;margin:0pt;text-align:left;">&#9746;</p>
			</td>
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			<td style="vertical-align:top;width:30.3%;">
			<p style="font-family:'Times New Roman', Times, serif;font-size:10pt;margin:0pt;text-align:left;">&nbsp;</p>
			</td>
			<td style="vertical-align:top;width:5.1%;">
			<p style="font-family:'Times New Roman', Times, serif;font-size:10pt;margin:0pt;text-align:left;">&nbsp;</p>
			</td>
			<td style="vertical-align:top;width:29.3%;">
			<p style="font-family:'Times New Roman', Times, serif;font-size:10pt;margin:0pt;text-align:left;">&nbsp;</p>
			</td>
			<td style="vertical-align:top;width:30.3%;">
			<p style="font-family:'Times New Roman', Times, serif;font-size:10pt;margin:0pt;text-align:left;">Emerging growth company</p>
			</td>
			<td style="vertical-align:top;width:5%;">&#9744;</td>
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</table>

<p style="font-family:'Times New Roman', Times, serif;font-size:10pt;margin:0pt 7.2pt;text-align:left;">&nbsp;</p>

<p style="font-family: &quot;Times New Roman&quot;, Times, serif; font-size: 10pt; margin: 0pt; text-align: justify;">If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided to Section&nbsp;7(a)(2)(B) of the Securities Act.&nbsp;&#9744;</p>

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<p style="font-family:Times New Roman;font-size:10pt;font-variant:normal;text-align:center;margin:0pt 0pt 0pt 8pt;"><b>EXPLANATORY NOTE</b></p>

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<p style="font-family: &quot;Times New Roman&quot;; font-size: 10pt; font-variant: normal; margin: 0pt; text-indent: 36pt; text-align: justify;"><font style="color:#000000;">Pursuant to General Instruction E of Form S-8, Genprex, Inc. (the &#8220;Registrant&#8221;) is filing this Registration Statement on Form&nbsp;S-8 (this &#8220;Registration Statement&#8221;) with the Securities and Exchange Commission&nbsp;(the &#8220;Commission&#8221;) for the purpose of registering an aggregate of 79,294 shares of the Registrant&#8217;s common stock, par value $0.001 per share (the &#8220;Common Stock&#8221;), which consists of (i) 74,294 additional shares of Common Stock issuable&nbsp;under the Registrant&#8217;s 2018 Equity Incentive Plan (the &#8220;2018 Plan&#8221;), and (ii) 5,000 shares of Common Stock issuable upon the vesting and exercise of outstanding stock options granted as an inducement award by the Registrant to a new employee in accordance with Nasdaq Listing Rule 5635(c)(4) (the &#8220;Inducement Award&#8221;). The number of shares of Common Stock available for grant and issuance under the 2018 Plan is subject to an automatic annual increase on the first day of each fiscal year beginning in 2019 by an amount equal to the lesser of (i) 5% of the outstanding shares of Common Stock on such date or (ii)&nbsp;an amount determined by the Board of Directors (the &#8220;Evergreen Provision&#8221;).&nbsp;On January&nbsp;1, 2024, the number of shares of Common Stock available for grant and issuance under the Plan increased by 74,294 shares and this Registration Statement registers such additional shares of Common Stock, which were available for grant and issuance under the Plan pursuant to the Evergreen Provision as of January&nbsp;1, 2024. The Inducement Award was approved by the Registrant&#8217;s Board of Directors in compliance with and in reliance on Nasdaq Listing Rule 5635(c)(4) and was granted outside of the 2018 Plan.&nbsp; All share data in this Registration Statement has been adjusted to reflect the one-for-forty (1-for-40) reverse stock split of the Registrant&#8217;s issued and outstanding shares of Common Stock effectuated as of 12:01 a.m. Eastern Time on February 2, 2024.</font></p>

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<p style="font-family: &quot;Times New Roman&quot;; font-size: 10pt; font-variant: normal; margin: 0pt; text-indent: 36pt; text-align: justify;">Pursuant to General Instruction E of Form&nbsp;S-8,&nbsp;the contents of the Registration Statements on Form&nbsp;S-8&nbsp;of the Registrant filed with the Commission&nbsp;on <a href="http://www.sec.gov/Archives/edgar/data/0001595248/000143774920006794/gnpx20200323_s8.htm" style="-sec-extract:exhibit;">April 2, 2020</a>&nbsp;(Registration&nbsp;No.&nbsp;333-237543), on <a href="http://www.sec.gov/Archives/edgar/data/1595248/000143774922020631/gnpx20220809_s8.htm" style="-sec-extract:exhibit;">August 16, 2022</a> (Registration&nbsp;No.&nbsp;333-266896) and on <a href="http://www.sec.gov/Archives/edgar/data/1595248/000143774923003784/gnpx20230214_s8.htm" style="-sec-extract:exhibit;">February 17, 2023</a> (Registration No. 333-269865), including any amendments thereto or filings incorporated therein, are incorporated herein by this reference to the extent not replaced or changed hereby.</p>

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<p style="background-color: rgb(255, 255, 255); font-family: &quot;Times New Roman&quot;, Times, serif; font-size: 10pt; margin: 0pt; text-indent: 36pt; text-align: justify;">In accordance with the instructional note to Part I of Form S-8 as promulgated by the Commission, the information specified by Part I of Form S-8 has been omitted from this Registration Statement.&nbsp;</p>

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<p style="font-family:'Times New Roman', Times, serif;font-size:10pt;margin:0pt;text-align:center;"><b>PART II </b></p>

<p style="font-family:'Times New Roman', Times, serif;font-size:10pt;margin:0pt;text-align:center;"><b>INFORMATION REQUIRED IN </b><b>THE REGISTRATION STATEMENT</b><b> </b></p>

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			<p style="font-family:'Times New Roman', Times, serif;font-size:10pt;margin:0pt;text-align:left;"><b>Incorporation of Documents by Reference.</b></p>
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<p style="font-family: &quot;Times New Roman&quot;, Times, serif; font-size: 10pt; margin: 0pt; text-indent: 36pt; text-align: justify;">The following documents, which have been filed by the Registrant with the Commission pursuant to the Securities Act of 1933, as amended (the &#8220;Securities Act&#8221;) and the Securities Exchange Act of 1934, as amended (the &#8220;Exchange Act&#8221;), are incorporated herein by reference:</p>

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			<p style="font-family:'Times New Roman';font-size:10pt;font-variant:normal;margin:0pt;">&#9679;</p>
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			<p style="font-family: &quot;Times New Roman&quot;; font-size: 10pt; font-variant: normal; margin: 0pt; text-align: justify;">The Registrant&#8217;s Annual Report on Form 10-K for the fiscal year ended December 31, 2023, filed with the Commission on <a href="http://www.sec.gov/ix?doc=/Archives/edgar/data/0001595248/000143774924010426/gnpx20231231_10k.htm" style="-sec-extract:exhibit;">April 1, 2024</a>;</p>
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			<p style="font-family:'Times New Roman';font-size:10pt;font-variant:normal;margin:0pt;">&#9679;</p>
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			<p style="font-family: &quot;Times New Roman&quot;; font-size: 10pt; font-variant: normal; margin: 0pt; text-align: justify;">The Registrant&#8217;s Current Reports on Form 8-K filed with the Commission on <a href="http://www.sec.gov/ix?doc=/Archives/edgar/data/1595248/000143774924000743/gnpx20240102_8k.htm" style="-sec-extract:exhibit;">January 5, 2024</a>, <a href="http://www.sec.gov/ix?doc=/Archives/edgar/data/1595248/000143774924002620/gnpx20240123_8k.htm" style="-sec-extract:exhibit;">January 31, 2024</a>, <a href="http://www.sec.gov/ix?doc=/Archives/edgar/data/1595248/000143774924002878/gnpx20240201_8k.htm" style="-sec-extract:exhibit;">February 2, 2024</a>, <a href="http://www.sec.gov/ix?doc=/Archives/edgar/data/1595248/000143774924003055/gnpx20240204_8k.htm" style="-sec-extract:exhibit;">February 5, 2024</a>, <a href="http://www.sec.gov/ix?doc=/Archives/edgar/data/1595248/000143774924005460/gnpx20240213_8k.htm" style="-sec-extract:exhibit;">February 26, 2024</a>, <a href="http://www.sec.gov/ix?doc=/Archives/edgar/data/1595248/000143774924006740/gnpx20240304_8k.htm" style="-sec-extract:exhibit;">March 6, 2024</a> and <a href="http://www.sec.gov/ix?doc=/Archives/edgar/data/1595248/000143774924008592/gnpx20240305_8k.htm" style="-sec-extract:exhibit;">March 20, 2024</a> (in each case, other than any portions thereof deemed furnished and not filed); and</p>
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			<td style="vertical-align: top; width: 2%;">&nbsp;</td>
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			<p style="font-family:'Times New Roman';font-size:10pt;font-variant:normal;margin:0pt;">&#9679;</p>
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			<p style="font-family: &quot;Times New Roman&quot;; font-size: 10pt; font-variant: normal; margin: 0pt; text-align: justify;">The description of the Registrant&#8217;s Common Stock contained in its Registration Statement on Form&nbsp;8-A&nbsp;(Registration&nbsp;No.&nbsp;001-38244)&nbsp;filed with the Commission on <a href="http://www.sec.gov/Archives/edgar/data/0001595248/000119312517309662/d454099d8a12b.htm" style="-sec-extract:exhibit;">October&nbsp;13, 2017</a> pursuant to Section&nbsp;12(b) of the Exchange Act, including any amendments or reports filed for the purpose of updating such description, including Exhibit 4.20 to the Registrant&#8217;s Annual Report on Form 10-K for the fiscal year ended December 31, 2023 filed with the Commission on <a href="http://www.sec.gov/Archives/edgar/data/1595248/000143774924010426/ex_600628.htm" style="-sec-extract:exhibit;">April 1, 2024</a>.</p>
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<p style="font-family: &quot;Times New Roman&quot;; font-size: 10pt; font-variant: normal; margin: 0pt; text-indent: 36pt; text-align: justify;">All documents filed by the Registrant pursuant to Section&nbsp;13(a), 13(c), 14 and 15(d) of the Exchange Act subsequent to the filing of this Registration Statement and prior to the filing of a post-effective amendment, which indicates that all securities offered hereby have been sold or which deregisters all securities then remaining unsold, shall be deemed to be incorporated by reference into this Registration Statement and to be a part hereof from the date of filing such documents, except as to specific sections of such documents as set forth therein; provided, however, that documents or information deemed to have been furnished and not filed in accordance with Commission rules shall not be deemed incorporated by reference into this Registration Statement. Any statement contained in a document incorporated or deemed to be incorporated by reference herein shall be deemed to be modified or superseded for purposes of this Registration Statement to the extent that a statement contained in any subsequently filed document, which also is deemed to be incorporated by reference herein, modifies or supersedes such statement.</p>

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			<p style="font-family:'Times New Roman', Times, serif;font-size:10pt;margin:0pt;text-align:left;"><b>Item 8.</b></p>
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			<p style="font-family:'Times New Roman', Times, serif;font-size:10pt;margin:0pt;text-align:left;"><b>Exhibits</b></p>
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			<p style="font-family:'Times New Roman', Times, serif;font-size:10pt;margin:0pt;text-align:center;"><b>Exhibit</b></p>

			<p style="font-family:'Times New Roman', Times, serif;font-size:10pt;margin:0pt;text-align:center;"><b>Number</b></p>
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			<p style="font-family:'Times New Roman', Times, serif;font-size:10pt;margin:0pt;text-align:left;">&nbsp;</p>
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			<p style="font-family:'Times New Roman', Times, serif;font-size:10pt;margin:0pt;text-align:left;"><b>Description of Exhibit</b></p>
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			<td style="vertical-align:top;width:8%;">&nbsp;</td>
			<td style="vertical-align:bottom;width:1%;">&nbsp;</td>
			<td style="vertical-align:top;width:91%;">&nbsp;</td>
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			<p style="font-family:'Times New Roman', Times, serif;font-size:10pt;margin:0pt;text-align:center;">4.1</p>
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			<td style="vertical-align:bottom;width:1%;">
			<p style="font-family:'Times New Roman', Times, serif;font-size:10pt;margin:0pt;text-align:left;">&nbsp;</p>
			</td>
			<td style="vertical-align: top; width: 91%; text-align: justify;"><a href="http://www.sec.gov/Archives/edgar/data/1595248/000143774924010426/ex_636683.htm" style="-sec-extract:exhibit;">Amended and Restated Certificate of Incorporation of the Registrant, dated April 3, 2018, as amended by the Certificate of Amendment of the Amended and Restated Certificate of Incorporation, filed with the Secretary of State of the State of Delaware on January 31, 2024 (incorporated by reference to Exhibit 3.1 to the Registrant&#8217;s Annual Report on Form 10-K for the fiscal year ended December 31, 2023 filed with the Commission on April 1, 2024).</a></td>
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			<p style="font-family:'Times New Roman', Times, serif;font-size:10pt;margin:0pt;text-align:left;">&nbsp;</p>
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			<p style="font-family:'Times New Roman', Times, serif;font-size:10pt;margin:0pt;text-align:left;">&nbsp;</p>
			</td>
			<td style="vertical-align:top;width:91%;">
			<p style="font-family:'Times New Roman', Times, serif;font-size:10pt;margin:0pt;text-align:left;">&nbsp;</p>
			</td>
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			<p style="font-family:'Times New Roman', Times, serif;font-size:10pt;margin:0pt;text-align:center;">4.2</p>
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			<p style="font-family:'Times New Roman', Times, serif;font-size:10pt;margin:0pt;text-align:left;">&nbsp;</p>
			</td>
			<td style="vertical-align: top; width: 91%; text-align: justify;"><a href="http://www.sec.gov/Archives/edgar/data/1595248/000143774923031830/ex_590644.htm" style="-sec-extract:exhibit;">Amended and Restated Bylaws of the Registrant, as amended by Amendment No. 1 adopted and approved by the Registrant&#8217;s Board of Directors on October 18, 2023 (incorporated by reference to Exhibit 3.1 to the Registrant&#8217;s Quarterly Report on Form 10-Q for the fiscal quarter ended September 30, 2023 filed with the Commission on November 14, 2023).</a></td>
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			<td style="vertical-align:top;width:8%;">&nbsp;</td>
			<td style="vertical-align:bottom;width:1%;">&nbsp;</td>
			<td style="vertical-align:top;width:91%;">&nbsp;</td>
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			<td style="vertical-align: top; width: 8%; text-align: center;">4.3</td>
			<td style="vertical-align:bottom;width:1%;">&nbsp;</td>
			<td style="vertical-align: top; width: 91%; text-align: justify;"><a href="http://www.sec.gov/Archives/edgar/data/1595248/000119312517286120/d415543dex41.htm" style="-sec-extract:exhibit;">Form of Common Stock Certificate of the Registrant (incorporated by reference to Exhibit 4.1 to the Registrant&#8217;s Registration Statement on Form S-1 (File No. 333-219386), as amended, originally filed on July 21, 2017).</a></td>
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			<p style="font-family:'Times New Roman', Times, serif;font-size:10pt;margin:0pt;text-align:left;">&nbsp;</p>
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			<td style="vertical-align:bottom;width:1%;">
			<p style="font-family:'Times New Roman', Times, serif;font-size:10pt;margin:0pt;text-align:left;">&nbsp;</p>
			</td>
			<td style="vertical-align:top;width:91%;">
			<p style="font-family: &quot;Times New Roman&quot;, Times, serif; font-size: 10pt; margin: 0pt; text-align: justify;">&nbsp;</p>
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			<p style="font-family:'Times New Roman', Times, serif;font-size:10pt;margin:0pt;text-align:center;">5.1*</p>
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			<td style="vertical-align:bottom;width:1%;">
			<p style="font-family:'Times New Roman', Times, serif;font-size:10pt;margin:0pt;text-align:left;">&nbsp;</p>
			</td>
			<td style="vertical-align:top;width:91%;">
			<p style="font-family: &quot;Times New Roman&quot;, Times, serif; font-size: 10pt; margin: 0pt; text-align: justify;"><a href="ex_618358.htm" style="-sec-extract:exhibit;">Opinion of Lowenstein Sandler LLP.</a></p>
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			<td style="vertical-align:top;width:8%;">
			<p style="font-family:'Times New Roman', Times, serif;font-size:10pt;margin:0pt;text-align:left;">&nbsp;</p>
			</td>
			<td style="vertical-align:bottom;width:1%;">
			<p style="font-family:'Times New Roman', Times, serif;font-size:10pt;margin:0pt;text-align:left;">&nbsp;</p>
			</td>
			<td style="vertical-align:top;width:91%;">
			<p style="font-family:'Times New Roman', Times, serif;font-size:10pt;margin:0pt;text-align:left;">&nbsp;</p>
			</td>
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			<td style="vertical-align: top; width: 8%; text-align: center;">23.1*</td>
			<td style="vertical-align:bottom;width:1%;">&nbsp;</td>
			<td style="vertical-align: top; width: 91%; text-align: justify;"><a href="ex_618359.htm" style="-sec-extract:exhibit;">Consent of WithumSmith+Brown, PC, Independent Registered Public Accounting Firm.</a></td>
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			<td style="vertical-align:top;width:8%;">&nbsp;</td>
			<td style="vertical-align:bottom;width:1%;">&nbsp;</td>
			<td style="vertical-align:top;width:91%;">&nbsp;</td>
		</tr>
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			<td style="vertical-align:top;width:8%;">
			<p style="font-family:'Times New Roman', Times, serif;font-size:10pt;margin:0pt;text-align:center;">23.2*</p>
			</td>
			<td style="vertical-align:bottom;width:1%;">
			<p style="font-family:'Times New Roman', Times, serif;font-size:10pt;margin:0pt;text-align:left;">&nbsp;</p>
			</td>
			<td style="vertical-align:top;width:91%;">
			<p style="font-family: &quot;Times New Roman&quot;, Times, serif; font-size: 10pt; margin: 0pt; text-align: justify;"><a href="ex_650882.htm" style="-sec-extract:exhibit;">Consent of Daszkal Bolton LLP, Independent Registered Public Accounting Firm.</a></p>
			</td>
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			<td style="vertical-align:top;width:8%;">&nbsp;</td>
			<td style="vertical-align:bottom;width:1%;">&nbsp;</td>
			<td style="vertical-align: top; width: 91%; text-align: justify;">&nbsp;</td>
		</tr>
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			<td style="vertical-align:top;width:8%;">
			<p style="font-family:'Times New Roman', Times, serif;font-size:10pt;margin:0pt;text-align:center;">23.3*</p>
			</td>
			<td style="vertical-align:bottom;width:1%;">
			<p style="font-family:'Times New Roman', Times, serif;font-size:10pt;margin:0pt;text-align:left;">&nbsp;</p>
			</td>
			<td style="vertical-align:top;width:91%;">
			<p style="font-family: &quot;Times New Roman&quot;, Times, serif; font-size: 10pt; margin: 0pt; text-align: justify;"><a href="ex_618358.htm" style="-sec-extract:exhibit;">Consent of Lowenstein Sandler LLP (included in Exhibit 5.1).</a></p>
			</td>
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			<td style="vertical-align:top;width:8%;">&nbsp;</td>
			<td style="vertical-align:bottom;width:1%;">&nbsp;</td>
			<td style="vertical-align: top; width: 91%; text-align: justify;">&nbsp;</td>
		</tr>
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			<td style="vertical-align:top;width:8%;">
			<p style="font-family:'Times New Roman', Times, serif;font-size:10pt;margin:0pt;text-align:center;">24.1*</p>
			</td>
			<td style="vertical-align:bottom;width:1%;">
			<p style="font-family:'Times New Roman', Times, serif;font-size:10pt;margin:0pt;text-align:left;">&nbsp;</p>
			</td>
			<td style="vertical-align: top; width: 91%; text-align: justify;"><a href="#poa" style="-sec-extract:exhibit;">Power of Attorney (included on the signature page to this Registration Statement on Form S-8).</a></td>
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			<td style="vertical-align:top;width:8%;">&nbsp;</td>
			<td style="vertical-align:bottom;width:1%;">&nbsp;</td>
			<td style="vertical-align:top;width:91%;">&nbsp;</td>
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		<tr>
			<td style="vertical-align: top; width: 8%; text-align: center;">99.1</td>
			<td style="vertical-align:bottom;width:1%;">&nbsp;</td>
			<td style="vertical-align: top; width: 91%; text-align: justify;"><a href="http://www.sec.gov/Archives/edgar/data/1595248/000143774924010426/ex_637850.htm" style="-sec-extract:exhibit;">Genprex, Inc. 2018 Equity Incentive Plan, dated April 3, 2018, including Forms of Award Agreements thereunder (incorporated by reference to Exhibit 10.3 to the Registrant&#8217;s Annual Report on Form 10-K for the fiscal year ended December 31, 2023 filed with the Commission on April 1, 2024.</a></td>
		</tr>
		<tr>
			<td style="vertical-align: top; width: 8%; text-align: center;">&nbsp;</td>
			<td style="vertical-align:bottom;width:1%;">&nbsp;</td>
			<td style="vertical-align: top; width: 91%; text-align: justify;">&nbsp;</td>
		</tr>
		<tr>
			<td style="vertical-align: top; width: 8%; text-align: center;">99.2</td>
			<td style="vertical-align:bottom;width:1%;">&nbsp;</td>
			<td style="vertical-align: top; width: 91%; text-align: justify;"><a href="http://www.sec.gov/Archives/edgar/data/1595248/000143774924010426/ex_637851.htm" style="-sec-extract:exhibit;">Genprex, Inc. Form of Inducement Grant (incorporated by reference to Exhibit 10.4 to the&nbsp;Registrant&#8217;s Annual Report on Form 10-K for the fiscal year ended December 31, 2023 filed with the Commission on April 1, 2024.</a></td>
		</tr>
		<tr>
			<td style="vertical-align: top; width: 8%; text-align: center;">&nbsp;</td>
			<td style="vertical-align:bottom;width:1%;">&nbsp;</td>
			<td style="vertical-align: top; width: 91%; text-align: justify;">&nbsp;</td>
		</tr>
		<tr>
			<td style="vertical-align: top; width: 8%; text-align: center;">107*</td>
			<td style="vertical-align:bottom;width:1%;">&nbsp;</td>
			<td style="vertical-align: top; width: 91%; text-align: justify;"><a href="ex_618360.htm" style="-sec-extract:exhibit;">Filing Fee Table.</a></td>
		</tr>

</table>

<p style="font-family:'Times New Roman', Times, serif;font-size:10pt;margin:0pt 7.2pt;text-align:left;">&nbsp;</p>

<p style="font-family: &quot;Times New Roman&quot;, Times, serif; font-size: 10pt; margin: 0pt 7.2pt; text-align: left; text-indent: -9pt;">* Filed herewith.</p>

<p style="font-family:'Times New Roman', Times, serif;font-size:10pt;margin:0pt;text-align:left;">&nbsp;</p>

<p style="font-family:'Times New Roman', Times, serif;font-size:10pt;margin:0pt;text-align:left;">&nbsp;</p>

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<p style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin: 0pt; text-align: left">&nbsp;</p>

<p style="font-family:'Times New Roman', Times, serif;font-size:10pt;margin:0pt 14.4pt;text-align:center;"><b>SIGNATURES</b></p>

<p style="font-family:'Times New Roman', Times, serif;font-size:10pt;margin:0pt 14.4pt;text-align:center;">&nbsp;</p>

<p style="font-family: &quot;Times New Roman&quot;, Times, serif; font-size: 10pt; margin: 0pt; text-indent: 36pt; text-align: justify;">Pursuant to the requirements of the Securities Act of 1933, the registrant certifies that it has reasonable grounds to believe that it meets all of the requirements for filing on Form&nbsp;S-8&nbsp;and has duly caused this registration statement to be signed on its behalf by the undersigned, thereunto duly authorized, in the City of Austin, State of Texas, on April 17, 2024.</p>

<p style="font-family:'Times New Roman', Times, serif;font-size:10pt;margin:0pt 14.4pt;text-align:left;text-indent:36pt;">&nbsp;</p>

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			<td style="vertical-align:middle;width:50%;">
			<p style="font-family:'Times New Roman', Times, serif;font-size:10pt;margin:0pt;text-align:left;">&nbsp;</p>
			</td>
			<td style="vertical-align:middle;width:50%;">
			<p style="font-family:'Times New Roman', Times, serif;font-size:10pt;margin:0pt;text-align:left;">GENPREX, INC.</p>

			<p style="font-family:'Times New Roman', Times, serif;font-size:10pt;margin:0pt;text-align:left;">&nbsp;</p>

			<p style="font-family:'Times New Roman', Times, serif;font-size:10pt;margin:0pt;text-align:left;">&nbsp;</p>

			<p style="font-family:'Times New Roman', Times, serif;font-size:10pt;margin:0pt;text-align:left;">By:&nbsp;<u> /s/ J. Rodney Varner</u>&nbsp;</p>

			<p style="font-family:'Times New Roman', Times, serif;font-size:10pt;margin-bottom:0pt;margin-left:18pt;margin-right:0pt;margin-top:0pt;text-align:left;">Name:&nbsp; J. Rodney Varner</p>

			<p style="font-family:'Times New Roman', Times, serif;font-size:10pt;margin-bottom:0pt;margin-left:18pt;margin-right:0pt;margin-top:0pt;text-align:left;">Title:&nbsp; <i>&nbsp;&nbsp;</i>Chief Executive Officer</p>
			</td>
		</tr>

</table>

<p style="font-family:'Times New Roman', Times, serif;font-size:10pt;margin:0pt 14.4pt;text-align:left;"><i>&nbsp;</i></p>

<p style="font-family:'Times New Roman', Times, serif;font-size:10pt;margin:0pt 14.4pt;text-align:center;"><b><a id="poa" name="poa">PO</a>WER OF ATTORNEY</b></p>

<p style="font-family:'Times New Roman', Times, serif;font-size:10pt;margin:0pt 14.4pt;text-align:center;">&nbsp;</p>

<p style="font-family: &quot;Times New Roman&quot;, Times, serif; font-size: 10pt; margin: 0pt; text-indent: 36pt; text-align: justify;">KNOW ALL PERSONS BY THESE PRESENTS, that each person whose signature appears below hereby constitutes and appoints J. Rodney Varner and Ryan Confer, and each of them, as his true and lawful&nbsp;attorney-in-fact&nbsp;and agent with the full power of substitution, for him or her in any and all capacities, to sign any and all amendments to this Registration Statement, including any and all post-effective amendments, and to file such amendments thereto, with exhibits thereto and other documents in connection therewith, with the Securities and Exchange Commission, granting unto said&nbsp;attorneys-in-fact&nbsp;and agents, and each of them full power and authority to do and perform each and every act and thing requisite and necessary to be done in connection therewith, as fully for all intents and purposes as he or she might or could do in person, hereby ratifying and confirming all that said&nbsp;attorneys-in-fact&nbsp;and agents, or his or her substitutes, may lawfully do or cause to be done by virtue hereof.</p>

<p style="font-family: &quot;Times New Roman&quot;, Times, serif; font-size: 10pt; margin: 0pt; text-indent: 36pt; text-align: justify;">&nbsp;</p>

<p style="font-family: &quot;Times New Roman&quot;, Times, serif; font-size: 10pt; margin: 0pt; text-indent: 36pt; text-align: justify;">Pursuant to the requirements of the Securities Act of 1933, this registration statement has been signed by the following persons&nbsp;in the capacities and on the dates indicated.</p>

<p style="font-family:'Times New Roman', Times, serif;font-size:10pt;margin:0pt 14.4pt;text-align:left;">&nbsp;</p>

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			<td style="vertical-align:top;width:33.3%;">
			<p style="font-family:'Times New Roman', Times, serif;font-size:10pt;margin:0pt;text-align:center;"><u>Signature</u></p>
			</td>
			<td style="vertical-align:top;width:33.3%;">
			<p style="font-family:'Times New Roman', Times, serif;font-size:10pt;margin:0pt;text-align:center;"><u>Title</u></p>
			</td>
			<td style="vertical-align:top;width:33.3%;">
			<p style="font-family:'Times New Roman', Times, serif;font-size:10pt;margin:0pt;text-align:center;"><u>Date</u></p>
			</td>
		</tr>
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			<td style="vertical-align:top;width:33.3%;">
			<p style="font-family:'Times New Roman', Times, serif;font-size:10pt;margin:0pt;text-align:center;">&nbsp;</p>

			<p style="font-family:'Times New Roman', Times, serif;font-size:10pt;margin:0pt;text-align:center;"><u>/s/ J. Rodney Varner</u></p>

			<p style="font-family:'Times New Roman', Times, serif;font-size:10pt;margin:0pt;text-align:center;">J. Rodney Varner</p>
			</td>
			<td style="vertical-align:top;width:33.3%;">
			<p style="font-family:'Times New Roman', Times, serif;font-size:10pt;margin:0pt;text-align:center;">&nbsp;</p>

			<p style="font-family:'Times New Roman', Times, serif;font-size:10pt;margin:0pt;text-align:center;">Chief Executive Officer and Director</p>

			<p style="font-family:'Times New Roman', Times, serif;font-size:10pt;margin:0pt;text-align:center;"><i>(Principal Executive Officer)</i></p>
			</td>
			<td style="vertical-align:top;width:33.3%;">
			<p style="font-family:'Times New Roman', Times, serif;font-size:10pt;margin:0pt;text-align:center;">&nbsp;</p>

			<p style="font-family:'Times New Roman', Times, serif;font-size:10pt;margin:0pt;text-align:center;">April 17, 2024</p>
			</td>
		</tr>
		<tr>
			<td style="vertical-align:top;width:33.3%;">
			<p style="font-family:'Times New Roman', Times, serif;font-size:10pt;margin:0pt;text-align:left;">&nbsp;</p>
			</td>
			<td style="vertical-align:top;width:33.3%;">
			<p style="font-family:'Times New Roman', Times, serif;font-size:10pt;margin:0pt;text-align:left;">&nbsp;</p>
			</td>
			<td style="vertical-align:top;width:33.3%;">
			<p style="font-family:'Times New Roman', Times, serif;font-size:10pt;margin:0pt;text-align:left;">&nbsp;</p>
			</td>
		</tr>
		<tr>
			<td style="vertical-align:top;width:33.3%;">
			<p style="font-family:'Times New Roman', Times, serif;font-size:10pt;margin:0pt;text-align:center;"><u>/s/ Ryan M. Confer</u></p>

			<p style="font-family:'Times New Roman', Times, serif;font-size:10pt;margin:0pt;text-align:center;">Ryan M. Confer</p>
			</td>
			<td style="vertical-align:top;width:33.3%;">
			<p style="font-family:'Times New Roman', Times, serif;font-size:10pt;margin:0pt;text-align:center;">Chief Financial Officer</p>

			<p style="font-family:'Times New Roman', Times, serif;font-size:10pt;margin:0pt;text-align:center;"><i>(Principal Financial and Accounting Officer)</i></p>
			</td>
			<td style="vertical-align: top; width: 33.3%; text-align: center;">April 17, 2024</td>
		</tr>
		<tr>
			<td style="vertical-align:top;width:33.3%;">
			<p style="font-family:'Times New Roman', Times, serif;font-size:10pt;margin:0pt;text-align:left;">&nbsp;</p>
			</td>
			<td style="vertical-align:top;width:33.3%;">
			<p style="font-family:'Times New Roman', Times, serif;font-size:10pt;margin:0pt;text-align:left;">&nbsp;</p>
			</td>
			<td style="vertical-align:top;width:33.3%;">
			<p style="font-family:'Times New Roman', Times, serif;font-size:10pt;margin:0pt;text-align:left;">&nbsp;</p>
			</td>
		</tr>
		<tr>
			<td style="vertical-align:top;width:33.3%;">
			<p style="font-family:'Times New Roman', Times, serif;font-size:10pt;margin:0pt;text-align:center;"><u>/s/&nbsp;Brent M. Longnecker</u></p>

			<p style="font-family:'Times New Roman', Times, serif;font-size:10pt;margin:0pt;text-align:center;">Brent M. Longnecker</p>
			</td>
			<td style="vertical-align:top;width:33.3%;">
			<p style="font-family:'Times New Roman', Times, serif;font-size:10pt;margin:0pt;text-align:center;">Director</p>
			</td>
			<td style="vertical-align: top; width: 33.3%; text-align: center;">April 17, 2024</td>
		</tr>
		<tr>
			<td style="vertical-align:top;width:33.3%;">&nbsp;</td>
			<td style="vertical-align:top;width:33.3%;">&nbsp;</td>
			<td style="vertical-align:top;width:33.3%;">&nbsp;</td>
		</tr>
		<tr>
			<td style="vertical-align:top;width:33.3%;">
			<p style="font-family:'Times New Roman', Times, serif;font-size:10pt;margin:0pt;text-align:center;"><u>/s/&nbsp;Jose Antonio Moreno Toscano</u></p>

			<p style="font-family:'Times New Roman', Times, serif;font-size:10pt;margin:0pt;text-align:center;">Jose Antonio Moreno Toscano</p>
			</td>
			<td style="vertical-align: top; width: 33.3%; text-align: center;">Director</td>
			<td style="vertical-align: top; width: 33.3%; text-align: center;">April 17, 2024</td>
		</tr>
		<tr>
			<td style="vertical-align:top;width:33.3%;">&nbsp;</td>
			<td style="vertical-align:top;width:33.3%;">&nbsp;</td>
			<td style="vertical-align:top;width:33.3%;">&nbsp;</td>
		</tr>
		<tr>
			<td style="vertical-align:top;width:33.3%;">
			<p style="font-family:'Times New Roman', Times, serif;font-size:10pt;margin:0pt;text-align:center;"><u>/s/&nbsp;Will R. Wilson, Jr.</u></p>

			<p style="font-family:'Times New Roman', Times, serif;font-size:10pt;margin:0pt;text-align:center;">Will R. Wilson, Jr.</p>
			</td>
			<td style="vertical-align: top; width: 33.3%; text-align: center;">Director</td>
			<td style="vertical-align: top; width: 33.3%; text-align: center;">April 17, 2024</td>
		</tr>

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[{"type": "S-8", "sequence": "1", "filename": "gnpx20240123_s8.htm", "description": "FORM S-8", "secsgml_size_bytes": 55016}]
{"company-data": {"conformed-name": "Genprex, Inc.", "cik": "0001595248", "assigned-sic": "2834", "organization-name": "03 Life Sciences", "irs-number": "900772347", "state-of-incorporation": "TX", "fiscal-year-end": "1231"}, "filing-values": {"form-type": "S-8", "act": "33", "file-number": "333-278758", "film-number": "24851571"}, "business-address": {"street1": "1601 TRINITY STREET, BLDG. B", "street2": "SUITE 3.322", "city": "AUSTIN", "state": "TX", "zip": "78712", "phone": "512-537-7997"}, "mail-address": {"street1": "1601 TRINITY STREET, BLDG. B", "street2": "SUITE 3.322", "city": "AUSTIN", "state": "TX", "zip": "78712"}}
gnpx20240123_s8.htm
As filed with the Securities and Exchange Commission on April 17
, 20
24
Registration No. 333-
UNITED STATES
SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM S-8
REGISTRATION STATEMENT
UNDER
THE SECURITIES ACT OF 1933
GENPREX, INC.
(Exact name of registrant as specified in its charter)
Delaware
90-0772347
(State or other jurisdiction of
incorporation or organization)
(I.R.S. Employer
Identification Number)
3300 Bee Cave Road #650-227
Austin, Texas 78746
(Address of Principal Executive Offices) (Zip Code)
Genprex, Inc. 2018 Equity Incentive Plan
Inducement Stock Options
(Full title of the plan)
J. Rodney Varner
Chief Executive Officer
3300 Bee Cave Road #650-227
Austin, TX 78746
(Name and address of agent for service)
(877) 774-4679
(Telephone number, including area code, of agent for service)
Copies to:
Kate Basmagian, Esq.
Lowenstein Sandler LLP
1251 Avenue of the Americas
New York, New York 10020
Tel: (212) 262-6700
Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, a smaller reporting company or an emerging growth company. See the definitions of "large accelerated filer," "accelerated filer," "smaller reporting company," and "emerging growth company" in Rule 12b-2 of the Exchange Act.
Large accelerated filer
☐
Accelerated filer
☐
Non-accelerated filer
☒
Smaller reporting company
☒
Emerging growth company
☐
If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided to Section 7(a)(2)(B) of the Securities Act. ☐
EXPLANATORY NOTE
Pursuant to General Instruction E of Form S-8, Genprex, Inc. (the "Registrant") is filing this Registration Statement on Form S-8 (this "Registration Statement") with the Securities and Exchange Commission (the "Commission") for the purpose of registering an aggregate of 79,294 shares of the Registrant's common stock, par value $0.001 per share (the "Common Stock"), which consists of (i) 74,294 additional shares of Common Stock issuable under the Registrant's 2018 Equity Incentive Plan (the "2018 Plan"), and (ii) 5,000 shares of Common Stock issuable upon the vesting and exercise of outstanding stock options granted as an inducement award by the Registrant to a new employee in accordance with Nasdaq Listing Rule 5635(c)(4) (the "Inducement Award"). The number of shares of Common Stock available for grant and issuance under the 2018 Plan is subject to an automatic annual increase on the first day of each fiscal year beginning in 2019 by an amount equal to the lesser of (i) 5% of the outstanding shares of Common Stock on such date or (ii) an amount determined by the Board of Directors (the "Evergreen Provision"). On January 1, 2024, the number of shares of Common Stock available for grant and issuance under the Plan increased by 74,294 shares and this Registration Statement registers such additional shares of Common Stock, which were available for grant and issuance under the Plan pursuant to the Evergreen Provision as of January 1, 2024. The Inducement Award was approved by the Registrant's Board of Directors in compliance with and in reliance on Nasdaq Listing Rule 5635(c)(4) and was granted outside of the 2018 Plan.  All share data in this Registration Statement has been adjusted to reflect the one-for-forty (1-for-40) reverse stock split of the Registrant's issued and outstanding shares of Common Stock effectuated as of 12:01 a.m. Eastern Time on February 2, 2024.
Pursuant to General Instruction E of Form S-8, the contents of the Registration Statements on Form S-8 of the Registrant filed with the Commission on
April 2, 2020
(Registration No. 333-237543), on
August 16, 2022
(Registration No. 333-266896) and on
February 17, 2023
(Registration No. 333-269865), including any amendments thereto or filings incorporated therein, are incorporated herein by this reference to the extent not replaced or changed hereby.
In accordance with the instructional note to Part I of Form S-8 as promulgated by the Commission, the information specified by Part I of Form S-8 has been omitted from this Registration Statement.
1
PART II
INFORMATION REQUIRED IN
THE REGISTRATION STATEMENT
Item 3.
Incorporation of Documents by Reference.
The following documents, which have been filed by the Registrant with the Commission pursuant to the Securities Act of 1933, as amended (the "Securities Act") and the Securities Exchange Act of 1934, as amended (the "Exchange Act"), are incorporated herein by reference:
●
The Registrant's Annual Report on Form 10-K for the fiscal year ended December 31, 2023, filed with the Commission on
April 1, 2024
;
●
The Registrant's Current Reports on Form 8-K filed with the Commission on
January 5, 2024
,
January 31, 2024
,
February 2, 2024
,
February 5, 2024
,
February 26, 2024
,
March 6, 2024
and
March 20, 2024
(in each case, other than any portions thereof deemed furnished and not filed); and
●
The description of the Registrant's Common Stock contained in its Registration Statement on Form 8-A (Registration No. 001-38244) filed with the Commission on
October 13, 2017
pursuant to Section 12(b) of the Exchange Act, including any amendments or reports filed for the purpose of updating such description, including Exhibit 4.20 to the Registrant's Annual Report on Form 10-K for the fiscal year ended December 31, 2023 filed with the Commission on
April 1, 2024
.
All documents filed by the Registrant pursuant to Section 13(a), 13(c), 14 and 15(d) of the Exchange Act subsequent to the filing of this Registration Statement and prior to the filing of a post-effective amendment, which indicates that all securities offered hereby have been sold or which deregisters all securities then remaining unsold, shall be deemed to be incorporated by reference into this Registration Statement and to be a part hereof from the date of filing such documents, except as to specific sections of such documents as set forth therein; provided, however, that documents or information deemed to have been furnished and not filed in accordance with Commission rules shall not be deemed incorporated by reference into this Registration Statement. Any statement contained in a document incorporated or deemed to be incorporated by reference herein shall be deemed to be modified or superseded for purposes of this Registration Statement to the extent that a statement contained in any subsequently filed document, which also is deemed to be incorporated by reference herein, modifies or supersedes such statement.
II-1
Item 8.
Exhibits
Exhibit
Number
Description of Exhibit
4.1
Amended and Restated Certificate of Incorporation of the Registrant, dated April 3, 2018, as amended by the Certificate of Amendment of the Amended and Restated Certificate of Incorporation, filed with the Secretary of State of the State of Delaware on January 31, 2024 (incorporated by reference to Exhibit 3.1 to the Registrant's Annual Report on Form 10-K for the fiscal year ended December 31, 2023 filed with the Commission on April 1, 2024).
4.2
Amended and Restated Bylaws of the Registrant, as amended by Amendment No. 1 adopted and approved by the Registrant's Board of Directors on October 18, 2023 (incorporated by reference to Exhibit 3.1 to the Registrant's Quarterly Report on Form 10-Q for the fiscal quarter ended September 30, 2023 filed with the Commission on November 14, 2023).
4.3
Form of Common Stock Certificate of the Registrant (incorporated by reference to Exhibit 4.1 to the Registrant's Registration Statement on Form S-1 (File No. 333-219386), as amended, originally filed on July 21, 2017).
5.1*
Opinion of Lowenstein Sandler LLP.
23.1*
Consent of WithumSmith+Brown, PC, Independent Registered Public Accounting Firm.
23.2*
Consent of Daszkal Bolton LLP, Independent Registered Public Accounting Firm.
23.3*
Consent of Lowenstein Sandler LLP (included in Exhibit 5.1).
24.1*
Power of Attorney (included on the signature page to this Registration Statement on Form S-8).
99.1
Genprex, Inc. 2018 Equity Incentive Plan, dated April 3, 2018, including Forms of Award Agreements thereunder (incorporated by reference to Exhibit 10.3 to the Registrant's Annual Report on Form 10-K for the fiscal year ended December 31, 2023 filed with the Commission on April 1, 2024.
99.2
Genprex, Inc. Form of Inducement Grant (incorporated by reference to Exhibit 10.4 to the Registrant's Annual Report on Form 10-K for the fiscal year ended December 31, 2023 filed with the Commission on April 1, 2024.
107*
Filing Fee Table.
* Filed herewith.
II-2
SIGNATURES
Pursuant to the requirements of the Securities Act of 1933, the registrant certifies that it has reasonable grounds to believe that it meets all of the requirements for filing on Form S-8 and has duly caused this registration statement to be signed on its behalf by the undersigned, thereunto duly authorized, in the City of Austin, State of Texas, on April 17, 2024.
GENPREX, INC.
By:
/s/ J. Rodney Varner
Name:  J. Rodney Varner
Title:
Chief Executive Officer
PO
WER OF ATTORNEY
KNOW ALL PERSONS BY THESE PRESENTS, that each person whose signature appears below hereby constitutes and appoints J. Rodney Varner and Ryan Confer, and each of them, as his true and lawful attorney-in-fact and agent with the full power of substitution, for him or her in any and all capacities, to sign any and all amendments to this Registration Statement, including any and all post-effective amendments, and to file such amendments thereto, with exhibits thereto and other documents in connection therewith, with the Securities and Exchange Commission, granting unto said attorneys-in-fact and agents, and each of them full power and authority to do and perform each and every act and thing requisite and necessary to be done in connection therewith, as fully for all intents and purposes as he or she might or could do in person, hereby ratifying and confirming all that said attorneys-in-fact and agents, or his or her substitutes, may lawfully do or cause to be done by virtue hereof.
Pursuant to the requirements of the Securities Act of 1933, this registration statement has been signed by the following persons in the capacities and on the dates indicated.
Signature
Title
Date
/s/ J. Rodney Varner
J. Rodney Varner
Chief Executive Officer and Director
(Principal Executive Officer)
April 17, 2024
/s/ Ryan M. Confer
Ryan M. Confer
Chief Financial Officer
(Principal Financial and Accounting Officer)
April 17, 2024
/s/ Brent M. Longnecker
Brent M. Longnecker
Director
April 17, 2024
/s/ Jose Antonio Moreno Toscano
Jose Antonio Moreno Toscano
Director
April 17, 2024
/s/ Will R. Wilson, Jr.
Will R. Wilson, Jr.
Director
April 17, 2024
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