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<TITLE>Santarus, Inc.</TITLE>
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<P align="center" style="font-size: 10pt"><B>As filed with the
Securities and Exchange Commission on April&nbsp;1, 2004</B>



<DIV align="right" style="font-size: 10pt"><B>Registration
No.&nbsp;333-&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</B></DIV>



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<DIV align="center" style="font-size: 14pt"><B>SECURITIES AND EXCHANGE COMMISSION</B></DIV>

<DIV align="center" style="font-size: 12pt"><B>Washington, D.C. 20549</B>
</DIV>

<DIV align="center" style="font-size: 10pt"><HR size="1" noshade width="20%" align="center"></DIV>

<P>
<DIV align="center" style="font-size: 18pt"><B>FORM S-8</B></DIV>


<DIV align="center" style="font-size: 10pt"><B>REGISTRATION STATEMENT</B><BR>
<B><I>Under<BR>
The Securities Act of 1933</I></B></DIV>


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<P align="center" style="font-size: 24pt"><B>SANTARUS, INC.</B>

<DIV align="center" style="font-size: 10pt">(Exact name of Registrant as specified in its charter)</DIV>


<DIV align="center" style="font-size: 10pt"><HR size="1" noshade width="20%" align="center"></DIV>


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    <TD align="center" valign="top"><B>Delaware</B>
</TD>
    <TD>&nbsp;</TD>
    <TD align="center" valign="top"><B>33-0734433</B></TD>
</TR>

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    <TD align="center" valign="top"><HR size="1" noshade width="40%" align="center">
</TD>
    <TD>&nbsp;</TD>
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</TR>

<TR valign="bottom">
    <TD align="center" valign="top">(State of incorporation)
</TD>
    <TD>&nbsp;</TD>
    <TD align="center" valign="top">(I.R.S. Employer Identification No.)</TD>
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<P align="center" style="font-size: 10pt"><B>10590 West Ocean Air Drive<BR>
Suite&nbsp;200<BR>
San Diego, CA 92130<BR>
(858)&nbsp;314-5700</B>



<P align="center" style="font-size: 10pt">(Address of principal executive offices, including zip code, and telephone number)


<DIV align="center" style="font-size: 10pt"><HR size="1" noshade width="20%" align="center"></DIV>



<P align="center" style="font-size: 10pt"><B>Santarus, Inc. 2004 Equity Incentive Award Plan<BR>
Santarus, Inc. 1998 Stock Option Plan<BR>
Santarus, Inc. Employee Stock Purchase Plan</B><BR>
(Full title of the plans)


<DIV align="center" style="font-size: 10pt"><HR size="1" noshade width="20%" align="center"></DIV>



<P align="center" style="font-size: 10pt"><B>Gerald T. Proehl<BR>
President and Chief Executive Officer<BR>
Santarus, Inc.<BR>
10590 West Ocean Air Drive<BR>
Suite&nbsp;200<BR>
San Diego, CA 92130<BR>
(858)&nbsp;314-5700</B><BR>
(Name, address, and telephone number, including area code, of agent for service)


<DIV align="center" style="font-size: 10pt"><HR size="1" noshade width="20%" align="center"></DIV>



<P align="center" style="font-size: 10pt"><B><I>Copies to:</I></B><BR>
<B>Scott N. Wolfe, Esq.<BR>
Latham &#038; Watkins LLP<BR>
12636 High Bluff Drive, Suite&nbsp;300<BR>
San Diego, CA 92130<BR>
(858)&nbsp;523-5400</B>


<DIV align="center" style="font-size: 10pt"><HR size="1" noshade width="20%" align="center"></DIV>



<P align="center" style="font-size: 10pt"><B>CALCULATION OF REGISTRATION FEE</B>


<DIV align="center">
<TABLE style="font-size: 10pt" cellspacing="0" border="0" cellpadding="0" width="100%">
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<TR valign="bottom">
    <TD width="35%">&nbsp;</TD>
    <TD width="5%">&nbsp;</TD>
    <TD width="15%">&nbsp;</TD>
    <TD width="1%">&nbsp;</TD>
    <TD width="16%">&nbsp;</TD>
    <TD width="5%">&nbsp;</TD>
    <TD width="3%">&nbsp;</TD>
    <TD width="1%">&nbsp;</TD>
    <TD width="3%">&nbsp;</TD>
    <TD width="5%">&nbsp;</TD>
    <TD width="1%">&nbsp;</TD>
    <TD width="1%">&nbsp;</TD>
    <TD width="1%">&nbsp;</TD>
    <TD width="5%">&nbsp;</TD>
    <TD width="1%">&nbsp;</TD>
    <TD width="1%">&nbsp;</TD>
    <TD width="1%">&nbsp;</TD>
</TR>
<TR style="font-size: 8pt" valign="bottom">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD nowrap align="center" colspan="3"><B>Proposed</B></TD>
    <TD>&nbsp;</TD>
    <TD nowrap align="center" colspan="3"><B>Proposed</B></TD>
    <TD>&nbsp;</TD>
    <TD nowrap align="center" colspan="3"><B>&nbsp;</B></TD>
</TR>
<TR style="font-size: 8pt" valign="bottom">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD nowrap align="center" colspan="3"><B>Maximum</B></TD>
    <TD>&nbsp;</TD>
    <TD nowrap align="center" colspan="3"><B>Maximum</B></TD>
    <TD>&nbsp;</TD>
    <TD nowrap align="center" colspan="3"><B>&nbsp;</B></TD>
</TR>
<TR style="font-size: 8pt" valign="bottom">
    <TD nowrap align="center"><B> Title</B></TD>
    <TD>&nbsp;</TD>
    <TD nowrap align="center" colspan="3"><B>Amount</B></TD>
    <TD>&nbsp;</TD>
    <TD nowrap align="center" colspan="3"><B>Offering</B></TD>
    <TD>&nbsp;</TD>
    <TD nowrap align="center" colspan="3"><B>Aggregate</B></TD>
    <TD>&nbsp;</TD>
    <TD nowrap align="center" colspan="3"><B>Amount of</B></TD>
</TR>
<TR style="font-size: 8pt" valign="bottom">
    <TD nowrap align="center"><B>of Securities to</B></TD>
    <TD>&nbsp;</TD>
    <TD nowrap align="center" colspan="3"><B>to be</B></TD>
    <TD>&nbsp;</TD>
    <TD nowrap align="center" colspan="3"><B>Price</B></TD>
    <TD>&nbsp;</TD>
    <TD nowrap align="center" colspan="3"><B>Offering</B></TD>
    <TD>&nbsp;</TD>
    <TD nowrap align="center" colspan="3"><B>Registration</B></TD>
</TR>
<TR style="font-size: 8pt" valign="bottom">
    <TD nowrap align="center"><B>be Registered</B><HR size="1" noshade></TD>
    <TD>&nbsp;</TD>
    <TD nowrap align="center" colspan="3"><B>Registered(1)</B><HR size="1" noshade></TD>
    <TD>&nbsp;</TD>
    <TD nowrap align="center" colspan="3"><B>Per Share</B><HR size="1" noshade></TD>
    <TD>&nbsp;</TD>
    <TD nowrap align="center" colspan="3"><B>Price</B><HR size="1" noshade></TD>
    <TD>&nbsp;</TD>
    <TD nowrap align="center" colspan="3"><B>Fee</B><HR size="1" noshade></TD>
</TR>

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    <TD><DIV style="margin-left:10px; text-indent:-10px">Common Stock
$0.0001 par value</DIV></TD>
    <TD>&nbsp;</TD>
    <TD nowrap align="right">&nbsp;</TD>
    <TD align="right">7,148,539</TD>
    <TD nowrap>(2)</TD>
    <TD>&nbsp;</TD>
    <TD nowrap align="right">$</TD>
    <TD align="right">9.00</TD>
    <TD nowrap>(3)</TD>
    <TD>&nbsp;</TD>
    <TD align="right">$</TD>
    <TD>64,336,851</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD align="right">$</TD>
    <TD>8,151.48</TD>
    <TD>&nbsp;</TD>
</TR>

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</DIV>



<P align="center" style="font-size: 10pt">&nbsp;
</DIV>

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<DIV align="center">
<TABLE style="font-size: 10pt" cellspacing="0" border="0" cellpadding="0" width="100%">
<!-- Begin Table Head -->
<TR valign="bottom">
    <TD width="35%">&nbsp;</TD>
    <TD width="5%">&nbsp;</TD>
    <TD width="15%">&nbsp;</TD>
    <TD width="1%">&nbsp;</TD>
    <TD width="16%">&nbsp;</TD>
    <TD width="5%">&nbsp;</TD>
    <TD width="3%">&nbsp;</TD>
    <TD width="1%">&nbsp;</TD>
    <TD width="3%">&nbsp;</TD>
    <TD width="5%">&nbsp;</TD>
    <TD width="1%">&nbsp;</TD>
    <TD width="1%">&nbsp;</TD>
    <TD width="1%">&nbsp;</TD>
    <TD width="5%">&nbsp;</TD>
    <TD width="1%">&nbsp;</TD>
    <TD width="1%">&nbsp;</TD>
    <TD width="1%">&nbsp;</TD>
</TR>


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<TR valign="bottom">
    <TD><DIV style="margin-left:10px; text-indent:-10px">Common Stock
$0.0001 par value</DIV></TD>
    <TD>&nbsp;</TD>
    <TD nowrap align="right">&nbsp;</TD>
    <TD align="right">2,547,893</TD>
    <TD nowrap>(4)</TD>
    <TD>&nbsp;</TD>
    <TD nowrap align="right">$</TD>
    <TD align="right">2.39</TD>
    <TD nowrap>(5)</TD>
    <TD>&nbsp;</TD>
    <TD align="right">$</TD>
    <TD align="right">6,089,464.27</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD align="right">$</TD>
    <TD align="right">771.54</TD>
    <TD>&nbsp;</TD>
</TR>

<TR valign="bottom">
    <TD><DIV style="margin-left:10px; text-indent:-10px">Common Stock
$0.0001 par value</DIV></TD>
    <TD>&nbsp;</TD>
    <TD nowrap align="right">&nbsp;</TD>
    <TD align="right">1,000,000</TD>
    <TD nowrap>(6)</TD>
    <TD>&nbsp;</TD>
    <TD nowrap align="right">$</TD>
    <TD align="right">9.00</TD>
    <TD nowrap>(7)</TD>
    <TD>&nbsp;</TD>
    <TD align="right">$</TD>
    <TD align="right">9,000,000</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD align="right">$</TD>
    <TD align="right">1,140.30</TD>
    <TD>&nbsp;</TD>
</TR>

<TR style="font-size: 1px">
    <TD><DIV style="margin-left:10px; text-indent:-10px">&nbsp;</DIV></TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD align="right"><HR size="1" noshade>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD align="right"><HR size="1" noshade>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD align="right"><HR size="1" noshade>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD align="right"><HR size="1" noshade>&nbsp;</TD>
    <TD>&nbsp;</TD>
</TR>
<TR valign="bottom">
    <TD><DIV style="margin-left:10px; text-indent:-10px">Total</DIV></TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD align="right">10,696,432</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD align="right">&#151;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD align="right">$</TD>
    <TD>79,426,315.27</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD align="right">$</TD>
    <TD align="right">10,063.32</TD>
    <TD>&nbsp;</TD>
</TR>
<TR style="font-size: 1px">
    <TD><DIV style="margin-left:10px; text-indent:-10px">&nbsp;</DIV></TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD align="right"><HR size="4" noshade>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD align="right"><HR size="4" noshade>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD align="right"><HR size="4" noshade>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD align="right"><HR size="4" noshade>&nbsp;</TD>
    <TD>&nbsp;</TD>
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<P>
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<TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
    <TD width="1%" nowrap align="right">(1)</TD>
    <TD width="1%">&nbsp;</TD>
    <TD>Pursuant to Rule&nbsp;416(a), this Registration Statement shall also cover any
additional shares of the Registrant&#146;s common stock, par value $0.0001 per
share (the &#147;Common Stock&#148;), that become issuable under any of the plans by
reason of any stock dividend, stock split, recapitalization or other
similar transaction effected without receipt of consideration that
increases the number of outstanding shares of Common Stock.</TD>
</TR>

<TR>
    <TD colspan="5">&nbsp;</TD>
</TR>

<TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
    <TD width="1%" nowrap align="right">(2)</TD>
    <TD width="1%">&nbsp;</TD>
    <TD>Represents 7,148,539 shares of Common Stock available for future issuance
under the Santarus, Inc. 2004 Equity Incentive Award Plan (the &#147;2004
Plan&#148;), which number consists of (a)&nbsp;3,500,000 shares of Common Stock
initially available for future grants under the 2004 Plan, (b)&nbsp;397,784
 shares of Common Stock remaining available for issuance under the
Santarus, Inc. 1998 Stock Option Plan (the &#147;1998 Plan&#148;) as of the date of
the Registrant&#146;s initial public offering, which shares will be available
for future issuance under the 2004 Plan, (c)&nbsp;up to 250,755 shares of
Common Stock issued pursuant to awards granted under the 1998 Plan prior
to the date of the Registrant&#146;s initial public offering which shares
remained subject to a repurchase right in favor of the Registrant, which
 shares of Common Stock will be available for future issuance under the
2004 Plan to the extent repurchased by the Registrant following the
Registrant&#146;s initial public offering, and (d)&nbsp;up to an additional
3,000,000 shares that may become issuable under the 2004 Plan pursuant to
its terms. In addition, to the extent outstanding awards under the 1998
Plan as of the date of the Registrant&#146;s initial public offering expire or
are canceled without having been exercised in full following the date of
the Registrant&#146;s initial public offering, the shares of Common Stock
subject to such awards will be available for future issuance under the
2004 Plan. As of the date of the Registrant&#146;s initial public offering,
2,547,893 shares of Common Stock were subject to outstanding options under
the 1998 Plan, which shares of Common Stock are registered pursuant to
footnote (4)&nbsp;below.</TD>
</TR>

<TR>
    <TD colspan="5">&nbsp;</TD>
</TR>

<TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
    <TD width="1%" nowrap align="right">(3)</TD>
    <TD width="1%">&nbsp;</TD>
    <TD>This estimate is made pursuant to Rule 457(h) solely for purposes of
calculating the registration fee. For the 7,148,539 shares of Common
Stock available for future grants under the 2004 Plan, the Proposed
Maximum Offering Price Per Share is $9.00, the initial public offering
price of the Registrant&#146;s Common Stock as set forth in the Registrant&#146;s
Prospectus filed with the Securities and Exchange Commission on April&nbsp;1,
2004 pursuant to Rule 424(b) under the Securities Act of 1933, as amended.</TD>
</TR>

<TR>
    <TD colspan="5">&nbsp;</TD>
</TR>

<TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
    <TD width="1%" nowrap align="right">(4)</TD>
    <TD width="1%">&nbsp;</TD>
    <TD>Represents 2,547,893 shares of Common Stock subject to outstanding
options under the 1998 Plan as of the date of the Registrant&#146;s initial
public offering. Any of such shares of Common Stock that are subject to
awards that expire or are canceled without having been exercised in full
following the date of the Registrant&#146;s initial public offering will be
available for future issuance under the 2004 Plan.</TD>
</TR>

<TR>
    <TD colspan="5">&nbsp;</TD>
</TR>

<TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
    <TD width="1%" nowrap align="right">(5)</TD>
    <TD width="1%">&nbsp;</TD>
    <TD>This estimate is made pursuant to Rule 457(h) solely for purposes of
calculating the registration fee. For the 2,547,893 shares of Common
Stock reserved for issuance upon the exercise of outstanding awards
granted under the 1998 Plan, the Proposed Maximum Offering Price Per Share
is $2.39&nbsp;per share, which is the weighted average exercise price of the
options granted under the 1998 Plan.</TD>
</TR>

<TR>
    <TD colspan="5">&nbsp;</TD>
</TR>

<TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
    <TD width="1%" nowrap align="right">(6)</TD>
    <TD width="1%">&nbsp;</TD>
    <TD>Represents 400,000 shares of Common Stock initially available for future
grants under the Santarus, Inc. Employee Stock Purchase Plan (the &#147;ESPP&#148;)
and up to an additional 600,000 shares that may become issuable under the
ESPP pursuant to its terms.</TD>
</TR>

<TR>
    <TD colspan="5">&nbsp;</TD>
</TR>

<TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
    <TD width="1%" nowrap align="right">(7)</TD>
    <TD width="1%">&nbsp;</TD>
    <TD>This estimate is made pursuant to Rule 457(h) solely for purposes of
calculating the registration fee. For the 1,000,000 shares of Common
Stock available for future grants under the ESPP, the Proposed Maximum
Offering Price Per Share is $9.00, the initial public offering price of
the Registrant&#146;s Common Stock as set forth in the Registrant&#146;s Prospectus
filed with the Securities and Exchange Commission on April&nbsp;1, 2004
pursuant to Rule 424(b) under the Securities Act of 1933, as amended.</TD>
</TR>

</TABLE>


<P>
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<P align="center" style="font-size: 10pt">&nbsp;
</DIV>

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<!-- TOC -->
<A name="toc"><DIV align="CENTER" style="page-break-before:always"><U><B>TABLE OF CONTENTS</B></U></DIV></A>

<P><CENTER>
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<TR>
	<TD width="3%"></TD>
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	<TD width="76%"></TD>
</TR>
<TR><TD colspan="9"><A HREF="#000">PART I</A></TD></TR>
<TR><TD></TD><TD colspan="8"><A HREF="#001"> Item&nbsp;1. Plan Information</A></TD></TR>
<TR><TD></TD><TD colspan="8"><A HREF="#002">Item&nbsp;2. Registrant Information and Employee Plan Annual Information</A></TD></TR>
<TR><TD colspan="9"><A HREF="#003">PART II</A></TD></TR>
<TR><TD></TD><TD colspan="8"><A HREF="#004">Item&nbsp;3. Incorporation of Documents by Reference</A></TD></TR>
<TR><TD></TD><TD colspan="8"><A HREF="#005">Item&nbsp;4. Description of Securities</A></TD></TR>
<TR><TD></TD><TD colspan="8"><A HREF="#006">Item&nbsp;5. Interests of Named Experts and Counsel</A></TD></TR>
<TR><TD></TD><TD colspan="8"><A HREF="#007">Item&nbsp;6. Indemnification of Directors and Officers</A></TD></TR>
<TR><TD></TD><TD colspan="8"><A HREF="#008"> Item&nbsp;7. Exemption From Registration Claimed</A></TD></TR>
<TR><TD></TD><TD colspan="8"><A HREF="#009"> Item&nbsp;8. Exhibits</A></TD></TR>
<TR><TD></TD><TD colspan="8"><A HREF="#010">Item&nbsp;9. Undertakings</A></TD></TR>
<TR><TD colspan="9"><A HREF="#011">SIGNATURES</A></TD></TR>
<TR><TD colspan="9"><A HREF="#012">INDEX TO EXHIBITS</A></TD></TR>
<TR><TD colspan="9"><A HREF="a97744exv5w1.txt">EXHIBIT 5.1</A></TD></TR>
<TR><TD colspan="9"><A HREF="a97744exv23w1.txt">EXHIBIT 23.1</A></TD></TR>
</TABLE>
</CENTER>
<!-- /TOC -->
<P><HR noshade><P>
<H5 align="left" style="page-break-before:always"><A HREF="#toc">Table of Contents</A></H5><P>



<DIV style="font-family: 'Times New Roman',Times,serif">



<!-- link1 "PART I" -->
<DIV align="left"><A NAME="000"></A></DIV>

<P align="center" style="font-size: 10pt"><B>PART I</B>



<P align="center" style="font-size: 10pt"><B>INFORMATION REQUIRED IN THE SECTION 10 (a)&nbsp;PROSPECTUS</B>


<!-- link2 " Item&nbsp;1. Plan Information" -->
<DIV align="left"><A NAME="001"></A></DIV>

<P align="left" style="font-size: 10pt"><B>Item&nbsp;1. Plan Information.</B>



<P align="left" style="font-size: 10pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Not required to be filed with this Registration Statement.

<!-- link2 "Item&nbsp;2. Registrant Information and Employee Plan Annual Information" -->
<DIV align="left"><A NAME="002"></A></DIV>

<P align="left" style="font-size: 10pt"><B>Item&nbsp;2. Registrant Information and Employee Plan Annual Information.</B>



<P align="left" style="font-size: 10pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Not required to be filed with this Registration Statement.

<!-- link1 "PART II" -->
<DIV align="left"><A NAME="003"></A></DIV>

<P align="center" style="font-size: 10pt"><B>PART II</B>



<P align="center" style="font-size: 10pt"><B>INFORMATION REQUIRED IN THE REGISTRATION STATEMENT</B>


<!-- link2 "Item&nbsp;3. Incorporation of Documents by Reference" -->
<DIV align="left"><A NAME="004"></A></DIV>

<P align="left" style="font-size: 10pt"><B>Item&nbsp;3. Incorporation of Documents by Reference.</B>



<P align="left" style="font-size: 10pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;The following documents previously filed with the Securities and Exchange
Commission (the &#147;SEC&#148;) by Santarus, Inc. (the &#147;Company&#148;), are incorporated by
reference in this Registration Statement:


<P>
<TABLE width="100%" border="0" cellpadding="0" cellspacing="0" style="font-size: 10pt">

<TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
    <TD width="4%" nowrap align="right">(a)</TD>
    <TD width="1%">&nbsp;</TD>
    <TD>the Prospectus filed by the Company pursuant to Rule
424(b) under the Securities Act of 1933, as amended (the
&#147;Securities Act&#148;), relating to the Registration Statement on Form
S-1, as amended (File No.&nbsp;333-111515), on April&nbsp;1, 2004, which
contains audited financial statements of the Company for the
latest fiscal year for which such statements have been filed; and</TD>
</TR>

<TR>
    <TD colspan="5">&nbsp;</TD>
</TR>

<TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
    <TD width="3%" nowrap align="right">(b)</TD>
    <TD width="1%">&nbsp;</TD>
    <TD>the description of the Company&#146;s Common Stock contained
in the Company&#146;s Registration Statement on Form 8-A filed under
Section 12(g) of the Securities Exchange Act of 1934, as amended
(the &#147;Exchange Act&#148;), on March&nbsp;24, 2004, including any subsequent
amendment or report filed for the purpose of amending such
description.</TD>
</TR>

</TABLE>


<P align="left" style="font-size: 10pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;All documents filed by the Company pursuant to Sections&nbsp;13(a), 13(c), 14
or 15(d) of the Exchange Act after the date of this Registration Statement and
prior to the filing of a post-effective amendment which indicates that all
securities offered have been sold or which deregisters all securities then
remaining unsold, are incorporated by reference in this Registration Statement
and are a part hereof from the date of filing such documents. Any statement
contained in a document incorporated or deemed to be incorporated by reference
herein shall be deemed to be modified or superseded for purposes of this
Registration Statement to the extent that a statement contained herein or in
any other subsequently filed document which also is or is deemed to be
incorporated by reference herein modifies or supersedes such statement. Any
such statement so modified or superseded shall not be deemed, except as so
modified or superseded, to constitute a part of this Registration Statement.

<!-- link2 "Item&nbsp;4. Description of Securities" -->
<DIV align="left"><A NAME="005"></A></DIV>

<P align="left" style="font-size: 10pt"><B>Item&nbsp;4. Description of Securities.</B>



<P align="left" style="font-size: 10pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Not applicable.


<P align="center" style="font-size: 10pt">Page 3
</DIV>

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<DIV style="font-family: 'Times New Roman',Times,serif">
<!-- link2 "Item&nbsp;5. Interests of Named Experts and Counsel" -->
<DIV align="left"><A NAME="006"></A></DIV>

<P align="left" style="font-size: 10pt"><B>Item&nbsp;5. Interests of Named Experts and Counsel.</B>



<P align="left" style="font-size: 10pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Not applicable.

<!-- link2 "Item&nbsp;6. Indemnification of Directors and Officers" -->
<DIV align="left"><A NAME="007"></A></DIV>

<P align="left" style="font-size: 10pt"><B>Item&nbsp;6. Indemnification of Directors and Officers.</B>



<P align="left" style="font-size: 10pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;The Company is incorporated under the laws of the State of Delaware. As
permitted by Section&nbsp;102 of the Delaware General Corporation Law, the Company
has adopted provisions in its amended and restated certificate of incorporation
and amended and restated bylaws that limit or eliminate the personal liability
of the Company&#146;s directors for a breach of their fiduciary duty of care as a
director. The duty of care generally requires that, when acting on behalf of
the corporation, directors exercise an informed business judgment based on all
material information reasonably available to them. Consequently, a director
will not be personally liable to the Company or its stockholders for monetary
damages or breach of fiduciary duty as a director, except for liability for:


<P>
<TABLE width="100%" border="0" cellpadding="0" cellspacing="0" style="font-size: 10pt">

<TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
    <TD width="3%" nowrap align="right">&#149;</TD>
    <TD width="1%">&nbsp;</TD>
    <TD>any breach of the director&#146;s duty of loyalty to the Company or its
stockholders;</TD>
</TR>

<TR>
    <TD colspan="5">&nbsp;</TD>
</TR>

<TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
    <TD width="3%" nowrap align="right">&#149;</TD>
    <TD width="1%">&nbsp;</TD>
    <TD>any act or omission not in good faith or that involves
intentional misconduct or a knowing violation of law;</TD>
</TR>

<TR>
    <TD colspan="5">&nbsp;</TD>
</TR>

<TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
    <TD width="3%" nowrap align="right">&#149;</TD>
    <TD width="1%">&nbsp;</TD>
    <TD>any act related to unlawful stock repurchases,
redemptions or other distributions or payment of dividends; or</TD>
</TR>

<TR>
    <TD colspan="5">&nbsp;</TD>
</TR>

<TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
    <TD width="3%" nowrap align="right">&#149;</TD>
    <TD width="1%">&nbsp;</TD>
    <TD>any transaction from which the director derived an improper
personal benefit.</TD>
</TR>

</TABLE>


<P align="left" style="font-size: 10pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;These limitations of liability do not affect the availability of equitable
remedies such as injunctive relief or rescission. The Company&#146;s amended and
restated certificate of incorporation also authorizes the Company to indemnify
its officers, directors and other agents to the fullest extent permitted under
Delaware law.


<P align="left" style="font-size: 10pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;As permitted by Section&nbsp;145 of the Delaware General Corporation Law, the
Company&#146;s bylaws provide that:


<P>
<TABLE width="100%" border="0" cellpadding="0" cellspacing="0" style="font-size: 10pt">

<TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
    <TD width="3%" nowrap align="right">&#149;</TD>
    <TD width="1%">&nbsp;</TD>
    <TD>the Company may indemnify its directors, officers and
employees to the fullest extent permitted by the Delaware General
Corporation Law, subject to limited exceptions;</TD>
</TR>

<TR>
    <TD colspan="5">&nbsp;</TD>
</TR>

<TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
    <TD width="3%" nowrap align="right">&#149;</TD>
    <TD width="1%">&nbsp;</TD>
    <TD>the Company may advance expenses to its directors,
officers and employees in connection with a legal proceeding to
the fullest extent permitted by the Delaware General Corporation
Law, subject to limited exceptions; and</TD>
</TR>

<TR>
    <TD colspan="5">&nbsp;</TD>
</TR>

<TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
    <TD width="3%" nowrap align="right">&#149;</TD>
    <TD width="1%">&nbsp;</TD>
    <TD>the rights provided in the Company&#146;s bylaws are not
exclusive.</TD>
</TR>

</TABLE>


<P align="left" style="font-size: 10pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;The Company&#146;s amended and restated certificate of incorporation and its
amended and restated bylaws provide for the indemnification provisions
described above. In addition, the Company has entered into separate
indemnification agreements with its directors and officers which may be broader
than the specific indemnification provisions contained in the Delaware General
Law. These indemnification agreements may require the Company, among other
things, to indemnify its


<P align="center" style="font-size: 10pt">Page 4
</DIV>
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<DIV style="font-family: 'Times New Roman',Times,serif">

<P align="left" style="font-size: 10pt">officers and directors against liabilities that may
arise by reason of their status or service as directors or officers, other than
liabilities arising from willful misconduct. These indemnification agreements
also may require the Company to advance any expenses incurred by the directors
or officers as a result of any proceeding against them as to which they could
be indemnified. In addition, the Company has purchased a policy of
directors&#146; and officers&#146; liability insurance that insures
our officers and directors against the cost of defense, settlement or
payment of a judgment in some circumstances.

<!-- link2 " Item&nbsp;7. Exemption From Registration Claimed" -->
<DIV align="left"><A NAME="008"></A></DIV>

<P align="left" style="font-size: 10pt"><B>Item&nbsp;7. Exemption From Registration Claimed</B>.



<P align="left" style="font-size: 10pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Not applicable.

<!-- link2 " Item&nbsp;8. Exhibits" -->
<DIV align="left"><A NAME="009"></A></DIV>

<P align="left" style="font-size: 10pt"><B>Item&nbsp;8. Exhibits.</B>



<P align="left" style="font-size: 10pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;The following is a list of exhibits filed as part of this Registration
Statement, which are incorporated herein:

<DIV align="center">
<TABLE style="font-size: 10pt" cellspacing="0" border="0" cellpadding="0" width="100%">
<!-- Begin Table Head -->
<TR valign="bottom">
    <TD width="13%">&nbsp;</TD>
    <TD width="3%">&nbsp;</TD>
    <TD width="84%">&nbsp;</TD>
</TR>
<TR style="font-size: 8pt" valign="bottom">
    <TD nowrap align="center"><B>Exhibit</B></TD>
    <TD>&nbsp;</TD>
    <TD nowrap align="center"><B>&nbsp;</B></TD>
</TR>
<TR style="font-size: 8pt" valign="bottom">
    <TD nowrap align="center"><B>Number</B><HR size="1" noshade></TD>
    <TD>&nbsp;</TD>
    <TD nowrap align="center"><B>Document</B><HR size="1" noshade></TD>
</TR>

<!-- End Table Head -->
<!-- Begin Table Body -->
<TR valign="bottom">

<TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;&nbsp;4.1*
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">Santarus, Inc. 2004 Equity Incentive Award Plan</TD>
</TR>

<TR valign="bottom">

<TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;&nbsp;4.2*
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">Santarus, Inc. 1998 Stock Option Plan</TD>
</TR>

<TR valign="bottom">

<TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;&nbsp;4.3*
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">Santarus, Inc. Employee Stock Purchase Plan</TD>
</TR>

<TR valign="bottom">

<TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;&nbsp;5.1**
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">Opinion of Latham &#038; Watkins LLP</TD>
</TR>

<TR valign="bottom">
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">23.1**
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">Consent of Ernst &#038; Young LLP, Independent Auditors</TD>
</TR>

<TR valign="bottom">
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">23.2**
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">Consent of Latham &#038; Watkins LLP (contained in Exhibit&nbsp;5.1)</TD>
</TR>

<TR valign="bottom">
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">24.1**
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">Power of Attorney (included in the signature page of this Registration Statement)</TD>
</TR>

<!-- End Table Body -->
</TABLE>
</DIV>




<P>
<HR size="1" width="18%" align="left" noshade>

<TABLE width="100%" border="0" cellpadding="0" cellspacing="0" style="font-size: 10pt">

<TR valign="top">
    <TD width="1%" nowrap align="left"><B>*</B></TD>
    <TD width="3%">&nbsp;</TD>
    <TD width="96%">Incorporated by reference to the Company&#146;s Registration Statement on Form
S-1, as amended (File No.&nbsp;333-111515).</TD>
</TR>

<TR><TD>&nbsp;</TD></TR>

<TR valign="top">
    <TD width="1%" nowrap align="left"><B>**</B></TD>
    <TD width="3%">&nbsp;</TD>
    <TD width="96%">Filed herewith.</TD>
</TR>

</TABLE>


<!-- link2 "Item&nbsp;9. Undertakings" -->
<DIV align="left"><A NAME="010"></A></DIV>

<P align="left" style="font-size: 10pt"><B>Item&nbsp;9. Undertakings.</B>



<P align="left" style="font-size: 10pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(a)&nbsp;The undersigned registrant hereby undertakes:


<P align="left" style="font-size: 10pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(1)&nbsp;To file, during any period in which offers or sales are being made, a
post-effective amendment to this Registration Statement;



<P align="left" style="margin-left:4%; font-size: 10pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(i) To include any prospectus required by Section&nbsp;10(a)(3) of
the Securities Act;



<P align="left" style="margin-left:4%; font-size: 10pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(ii) To reflect in the prospectus any facts or events arising
after the effective date of this Registration Statement (or the
most recent post-effective amendment thereof) which, individually
or in the aggregate, represent a fundamental change in the
information set forth in this Registration Statement.
Notwithstanding the foregoing, any increase or decrease in volume
of securities offered (if the total dollar value of securities
offered would not exceed that which was registered) and any
deviation from the low or high and of the estimated maximum
offering range may be reflected in the form of


<P align="center" style="font-size: 10pt">Page 5
</DIV>

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<DIV style="font-family: 'Times New Roman',Times,serif">


<P align="left" style="margin-left:4%; font-size: 10pt">prospectus filed
with the SEC pursuant to Rule 424(b) if, in the aggregate, the
changes in volume and price represent no more than 20&nbsp;percent
change in the maximum aggregate offering price set forth in the
&#147;Calculation of Registration Fee&#148; table in the effective
Registration Statement;



<P align="left" style="margin-left:4%; font-size: 10pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(iii) To include any material information with respect to the
plan of distribution not previously disclosed in this Registration
Statement or any material change to such information in this
Registration Statement;

<P align="left" style="font-size: 10pt"><I>provided, however</I>, that the undertakings set forth in paragraphs
(a)(1)(i) and (a)(1)(ii) above do not apply if the Registration
Statement is on Form S-3, Form S-8 or Form F-3, and the information
required to be included in a post-effective amendment by those
paragraphs is contained in periodic reports filed with or furnished to
the SEC by the registrant pursuant to Section&nbsp;13 or 15(d) of the
Exchange Act that are incorporated by reference in this Registration
Statement.



<P align="left" style="font-size: 10pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(2)&nbsp;That, for the purpose of determining any liability under the
Securities Act, each such post-effective amendment shall be deemed to be a new
registration statement relating to the securities offered therein, and the
offering of such securities at that time shall be deemed to be the initial <I>bona
fide </I>offering thereof.


<P align="left" style="font-size: 10pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(3)&nbsp;To remove from registration by means of a post-effective amendment any
of the securities being registered which remain unsold at the termination of
the offering.


<P align="left" style="font-size: 10pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(b)&nbsp;The undersigned registrant hereby undertakes that, for purposes of
determining any liability under the Securities Act, each filing of the
registrant&#146;s annual report pursuant to Section 13(a) or 15(d) of the Exchange
Act (and, where applicable, each filing of an employee benefit plan&#146;s annual
report pursuant to Section 15(d) of the Exchange Act) that is incorporated by
reference in this Registration Statement shall be deemed to be a new
registration statement relating to the securities offered therein, and the
offering of such securities at that time shall be deemed to be the initial bona
fide offering thereof.


<P align="left" style="font-size: 10pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(c)&nbsp;Insofar as indemnification for liabilities arising under the
Securities Act may be permitted to directors, officers and controlling persons
of the registrant pursuant to the foregoing provisions, or otherwise, the
registrant has been advised that in the opinion of the SEC such indemnification
is against public policy as expressed in the Securities Act and is, therefore,
unenforceable. In the event that a claim for indemnification against such
liabilities (other than the payment by the registrant of expenses incurred or
paid by a director, officer or controlling person of the registrant in the
successful defense of any action, suit or proceeding) is asserted by such
director, officer or controlling person in connection with the securities being
registered, the registrant will, unless in the opinion of its counsel the
matter has been settled by controlling precedent, submit to a court of
appropriate jurisdiction the question whether such indemnification by it is
against public policy as expressed in the Securities Act and will be governed
by the final adjudication of such issue.


<P align="center" style="font-size: 10pt">Page 6
</DIV>

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<DIV style="font-family: 'Times New Roman',Times,serif">
<!-- link1 "SIGNATURES" -->
<DIV align="left"><A NAME="011"></A></DIV>

<P align="center" style="font-size: 10pt"><B>SIGNATURES</B>



<P align="left" style="font-size: 10pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Pursuant to the requirements of the Securities Act, the Company certifies
that it has reasonable grounds to believe that it meets all of the requirements
for filing on Form S-8 and has duly caused this Registration Statement to be
signed on its behalf by the undersigned, thereunto duly authorized, in the City
of San Diego, State of California, on this 1<SUP>st</SUP> day of April, 2004.


<TABLE width="100%" border="0" cellspacing="0" cellpadding="0" style="font-size: 10pt">
<TR>
    <TD width="60%">&nbsp;</TD>
    <TD width="1%">&nbsp;</TD>
    <TD width="1%">&nbsp;</TD>
    <TD width="35%">&nbsp;</TD>
    <TD width="15%">&nbsp;</TD>
</TR>
<TR>
    <TD valign="top">&nbsp;</TD>
    <TD colspan="3">SANTARUS, INC.<BR>
&nbsp;</TD>
    <TD>&nbsp;</TD>
</TR><TR>
    <TD>&nbsp;</TD>
    <TD valign="top">By:&nbsp;&nbsp;</TD>
    <TD colspan="2" align="left">/s/ Gerald T.
Proehl<HR noshade size="1" width="90%"></TD>
    <TD>&nbsp;</TD>
</TR><TR>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD colspan="2">Gerald T. Proehl&nbsp;</TD>
    <TD>&nbsp;</TD>
</TR><TR>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD colspan="2">President and Chief Executive Officer&nbsp;</TD>
    <TD>&nbsp;</TD>
</TR>
<TR>
    <TD colspan="5">&nbsp;</TD>
</TR>
</TABLE>

<P align="center" style="font-size: 10pt"><B>POWER OF ATTORNEY</B>




<P align="left" style="font-size: 10pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;KNOW ALL PERSONS BY THESE PRESENTS, that each such person whose signature
appears below constitutes and appoints, jointly and severally, Gerald T. Proehl
and Debra P. Crawford his attorneys-in-fact, each with the power of
substitution, for him in any and all capacities, to sign any amendments to this
Registration Statement on Form S-8 (including post-effective amendments), and
to file the same, with all exhibits thereto, and other documents in connection
therewith, with the SEC, hereby ratifying and confirming all that each of said
attorneys-in-fact, or his substitute or substitutes, may do or cause to be done
by virtue hereof.


<P align="left" style="font-size: 10pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Pursuant to the requirements of the Securities Act, this Registration
Statement has been signed by the following persons in the capacities and on the
dates indicated.

<DIV align="center">
<TABLE style="font-size: 10pt" cellspacing="0" border="0" cellpadding="0" width="100%">
<!-- Begin Table Head -->
<TR valign="bottom">
    <TD width="30%">&nbsp;</TD>
    <TD width="5%">&nbsp;</TD>
    <TD width="30%">&nbsp;</TD>
    <TD width="5%">&nbsp;</TD>
    <TD width="30%">&nbsp;</TD>
</TR>
<TR style="font-size: 8pt" valign="bottom">
    <TD nowrap align="center"><B> Signature</B></TD>
    <TD>&nbsp;</TD>
    <TD nowrap align="center"><B>Title</B></TD>
    <TD>&nbsp;</TD>
    <TD nowrap align="center"><B>Date</B></TD>
</TR>

<!-- End Table Head -->
<!-- Begin Table Body -->
<TR valign="bottom">
    <TD align="center" valign="top">/s/ Gerald T. Proehl<BR>
<HR size="1" noshade>
Gerald T. Proehl
</TD>
    <TD>&nbsp;</TD>
    <TD align="center" valign="top">President, Chief Executive<BR>
Officer and Director<BR>
<I>(Principal Executive Officer)</I>
</TD>
    <TD>&nbsp;</TD>
    <TD align="center" valign="top">April&nbsp;1, 2004</TD>
</TR>

<TR valign="bottom">
    <TD align="center" valign="top">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD align="center" valign="top">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD align="center" valign="top">&nbsp;</TD>
</TR>

<TR valign="bottom">
    <TD align="center" valign="top">/s/ Debra P. Crawford<BR>
<HR size="1" noshade>
Debra P. Crawford
</TD>
    <TD>&nbsp;</TD>
    <TD align="center" valign="top">Senior Vice President, Chief<BR>
Financial Officer, Treasurer<BR>
and Secretary<BR>
<I>(Principal Financing and<BR>
Accounting Officer)</I>
</TD>
    <TD>&nbsp;</TD>
    <TD align="center" valign="top">April&nbsp;1, 2004</TD>
</TR>

<TR valign="bottom">
    <TD align="center" valign="top">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD align="center" valign="top">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD align="center" valign="top">&nbsp;</TD>
</TR>

<TR valign="bottom">
    <TD align="center" valign="top">/s/ David F. Hale<BR>
<HR size="1" noshade>
David F. Hale
</TD>
    <TD>&nbsp;</TD>
    <TD align="center" valign="top">Chairman of the Board
</TD>
    <TD>&nbsp;</TD>
    <TD align="center" valign="top">April&nbsp;1, 2004</TD>
</TR>

<TR valign="bottom">
    <TD align="center" valign="top">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD align="center" valign="top">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD align="center" valign="top">&nbsp;</TD>
</TR>

<TR valign="bottom">
    <TD align="center" valign="top">/s/ Rodney A. Ferguson, J.D., Ph.D.<BR>
<HR size="1" noshade>
Rodney A. Ferguson, J.D., Ph.D.
</TD>
    <TD>&nbsp;</TD>
    <TD align="center" valign="top">Director
</TD>
    <TD>&nbsp;</TD>
    <TD align="center" valign="top">April&nbsp;1, 2004</TD>
</TR>

<!-- End Table Body -->
</TABLE>
</DIV>



<P align="center" style="font-size: 10pt">Page 7
</DIV>

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<DIV style="font-family: 'Times New Roman',Times,serif">

<DIV align="center">
<TABLE style="font-size: 10pt" cellspacing="0" border="0" cellpadding="0" width="100%">
<!-- Begin Table Head -->
<TR valign="bottom">
    <TD width="30%">&nbsp;</TD>
    <TD width="5%">&nbsp;</TD>
    <TD width="30%">&nbsp;</TD>
    <TD width="5%">&nbsp;</TD>
    <TD width="30%">&nbsp;</TD>
</TR>
<TR style="font-size: 8pt" valign="bottom">
    <TD nowrap align="center"><B> Signature</B></TD>
    <TD>&nbsp;</TD>
    <TD nowrap align="center"><B>Title</B></TD>
    <TD>&nbsp;</TD>
    <TD nowrap align="center"><B>Date</B></TD>
</TR>

<!-- End Table Head -->
<!-- Begin Table Body -->
<TR valign="bottom">
    <TD align="center" valign="top">/s/ Maxine Gowen, Ph.D.<BR>
<HR size="1" noshade>
Maxine Gowen, Ph.D.
</TD>
    <TD>&nbsp;</TD>
    <TD align="center" valign="top">Director
</TD>
    <TD>&nbsp;</TD>
    <TD align="center" valign="top">April&nbsp;1, 2004</TD>
</TR>

<TR valign="bottom">
    <TD align="center" valign="top">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD align="center" valign="top">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD align="center" valign="top">&nbsp;</TD>
</TR>

<TR valign="bottom">
    <TD align="center" valign="top">/s/ Michael E. Herman<BR>
<HR size="1" noshade>
Michael E. Herman
</TD>
    <TD>&nbsp;</TD>
    <TD align="center" valign="top">Director
</TD>
    <TD>&nbsp;</TD>
    <TD align="center" valign="top">April&nbsp;1, 2004</TD>
</TR>

<TR valign="bottom">
    <TD align="center" valign="top">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD align="center" valign="top">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD align="center" valign="top">&nbsp;</TD>
</TR>

<TR valign="bottom">
    <TD align="center" valign="top">/s/ Arthur J. Klausner<BR>
<HR size="1" noshade>
Arthur J. Klausner
</TD>
    <TD>&nbsp;</TD>
    <TD align="center" valign="top">Director
</TD>
    <TD>&nbsp;</TD>
    <TD align="center" valign="top">April&nbsp;1, 2004</TD>
</TR>

<TR valign="bottom">
    <TD align="center" valign="top">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD align="center" valign="top">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD align="center" valign="top">&nbsp;</TD>
</TR>

<TR valign="bottom">
    <TD align="center" valign="top">/s/ Frederik Vincent van der Have<BR>
<HR size="1" noshade>
Frederik Vincent van der Have
</TD>
    <TD>&nbsp;</TD>
    <TD align="center" valign="top">Director
</TD>
    <TD>&nbsp;</TD>
    <TD align="center" valign="top">April&nbsp;1, 2004</TD>
</TR>

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<DIV style="font-family: 'Times New Roman',Times,serif">


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<P align="center" style="font-size: 10pt"><B>INDEX TO EXHIBITS</B>


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<TABLE style="font-size: 10pt" cellspacing="0" border="0" cellpadding="0" width="100%">
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<TR valign="bottom">
    <TD width="13%">&nbsp;</TD>
    <TD width="3%">&nbsp;</TD>
    <TD width="84%">&nbsp;</TD>
</TR>
<TR style="font-size: 8pt" valign="bottom">
    <TD nowrap align="center"><B>Exhibit</B></TD>
    <TD>&nbsp;</TD>
    <TD nowrap align="center"><B>&nbsp;</B></TD>
</TR>
<TR style="font-size: 8pt" valign="bottom">
    <TD nowrap align="center"><B>Number</B><HR size="1" noshade></TD>
    <TD>&nbsp;</TD>
    <TD nowrap align="center"><B>Document</B><HR size="1" noshade></TD>
</TR>

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<TR valign="bottom">

<TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;&nbsp;4.1*
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">Santarus, Inc. 2004 Equity Incentive Award Plan</TD>
</TR>

<TR valign="bottom">

<TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;&nbsp;4.2*
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">Santarus, Inc. 1998 Stock Option Plan</TD>
</TR>

<TR valign="bottom">

<TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;&nbsp;4.3*
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">Santarus, Inc. Employee Stock Purchase Plan</TD>
</TR>

<TR valign="bottom">

<TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;&nbsp;5.1**
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">Opinion of Latham &#038; Watkins LLP</TD>
</TR>

<TR valign="bottom">
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">23.1**
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">Consent of Ernst &#038; Young LLP, Independent Auditors</TD>
</TR>

<TR valign="bottom">
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">23.2**
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">Consent of Latham &#038; Watkins LLP (contained in Exhibit&nbsp;5.1)</TD>
</TR>

<TR valign="bottom">
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">24.1**
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">Power of Attorney (included in the signature page of this Registration Statement)</TD>
</TR>

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    <TD width="1%" nowrap align="left"><B>*</B></TD>
    <TD width="3%">&nbsp;</TD>
    <TD width="96%">Incorporated by reference to the Company&#146;s Registration Statement on Form
S-1, as amended (File No.&nbsp;333-111515).</TD>
</TR>

<TR><TD>&nbsp;</TD></TR>

<TR valign="top">
    <TD width="1%" nowrap align="right"><B>**</B></TD>
    <TD width="3%">&nbsp;</TD>
    <TD width="96%">Filed herewith.</TD>
</TR>

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</HTML>
[{"type": "S-8", "sequence": "1", "filename": "a97744sv8.htm", "description": "FORM S-8", "secsgml_size_bytes": 50526}]
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Santarus, Inc.
Table of Contents
As filed with the
Securities and Exchange Commission on April 1, 2004
Registration
No. 333-
SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM S-8
REGISTRATION STATEMENT
Under
The Securities Act of 1933
SANTARUS, INC.
(Exact name of Registrant as specified in its charter)
Delaware
33-0734433
(State of incorporation)
(I.R.S. Employer Identification No.)
10590 West Ocean Air Drive
Suite 200
San Diego, CA 92130
(858) 314-5700
(Address of principal executive offices, including zip code, and telephone number)
Santarus, Inc. 2004 Equity Incentive Award Plan
Santarus, Inc. 1998 Stock Option Plan
Santarus, Inc. Employee Stock Purchase Plan
(Full title of the plans)
Gerald T. Proehl
President and Chief Executive Officer
Santarus, Inc.
10590 West Ocean Air Drive
Suite 200
San Diego, CA 92130
(858) 314-5700
(Name, address, and telephone number, including area code, of agent for service)
Copies to:
Scott N. Wolfe, Esq.
Latham & Watkins LLP
12636 High Bluff Drive, Suite 300
San Diego, CA 92130
(858) 523-5400
CALCULATION OF REGISTRATION FEE
Proposed
Proposed
Maximum
Maximum
Title
Amount
Offering
Aggregate
Amount of
of Securities to
to be
Price
Offering
Registration
be Registered
Registered(1)
Per Share
Price
Fee
Common Stock
$0.0001 par value
7,148,539
(2)
$
9.00
(3)
$
64,336,851
$
8,151.48
Table of Contents
Common Stock
$0.0001 par value
2,547,893
(4)
$
2.39
(5)
$
6,089,464.27
$
771.54
Common Stock
$0.0001 par value
1,000,000
(6)
$
9.00
(7)
$
9,000,000
$
1,140.30
Total
10,696,432
—
$
79,426,315.27
$
10,063.32
(1)
Pursuant to Rule 416(a), this Registration Statement shall also cover any
additional shares of the Registrant's common stock, par value $0.0001 per
share (the "Common Stock"), that become issuable under any of the plans by
reason of any stock dividend, stock split, recapitalization or other
similar transaction effected without receipt of consideration that
increases the number of outstanding shares of Common Stock.
(2)
Represents 7,148,539 shares of Common Stock available for future issuance
under the Santarus, Inc. 2004 Equity Incentive Award Plan (the "2004
Plan"), which number consists of (a) 3,500,000 shares of Common Stock
initially available for future grants under the 2004 Plan, (b) 397,784
 shares of Common Stock remaining available for issuance under the
Santarus, Inc. 1998 Stock Option Plan (the "1998 Plan") as of the date of
the Registrant's initial public offering, which shares will be available
for future issuance under the 2004 Plan, (c) up to 250,755 shares of
Common Stock issued pursuant to awards granted under the 1998 Plan prior
to the date of the Registrant's initial public offering which shares
remained subject to a repurchase right in favor of the Registrant, which
 shares of Common Stock will be available for future issuance under the
2004 Plan to the extent repurchased by the Registrant following the
Registrant's initial public offering, and (d) up to an additional
3,000,000 shares that may become issuable under the 2004 Plan pursuant to
its terms. In addition, to the extent outstanding awards under the 1998
Plan as of the date of the Registrant's initial public offering expire or
are canceled without having been exercised in full following the date of
the Registrant's initial public offering, the shares of Common Stock
subject to such awards will be available for future issuance under the
2004 Plan. As of the date of the Registrant's initial public offering,
2,547,893 shares of Common Stock were subject to outstanding options under
the 1998 Plan, which shares of Common Stock are registered pursuant to
footnote (4) below.
(3)
This estimate is made pursuant to Rule 457(h) solely for purposes of
calculating the registration fee. For the 7,148,539 shares of Common
Stock available for future grants under the 2004 Plan, the Proposed
Maximum Offering Price Per Share is $9.00, the initial public offering
price of the Registrant's Common Stock as set forth in the Registrant's
Prospectus filed with the Securities and Exchange Commission on April 1,
2004 pursuant to Rule 424(b) under the Securities Act of 1933, as amended.
(4)
Represents 2,547,893 shares of Common Stock subject to outstanding
options under the 1998 Plan as of the date of the Registrant's initial
public offering. Any of such shares of Common Stock that are subject to
awards that expire or are canceled without having been exercised in full
following the date of the Registrant's initial public offering will be
available for future issuance under the 2004 Plan.
(5)
This estimate is made pursuant to Rule 457(h) solely for purposes of
calculating the registration fee. For the 2,547,893 shares of Common
Stock reserved for issuance upon the exercise of outstanding awards
granted under the 1998 Plan, the Proposed Maximum Offering Price Per Share
is $2.39 per share, which is the weighted average exercise price of the
options granted under the 1998 Plan.
(6)
Represents 400,000 shares of Common Stock initially available for future
grants under the Santarus, Inc. Employee Stock Purchase Plan (the "ESPP")
and up to an additional 600,000 shares that may become issuable under the
ESPP pursuant to its terms.
(7)
This estimate is made pursuant to Rule 457(h) solely for purposes of
calculating the registration fee. For the 1,000,000 shares of Common
Stock available for future grants under the ESPP, the Proposed Maximum
Offering Price Per Share is $9.00, the initial public offering price of
the Registrant's Common Stock as set forth in the Registrant's Prospectus
filed with the Securities and Exchange Commission on April 1, 2004
pursuant to Rule 424(b) under the Securities Act of 1933, as amended.
TABLE OF CONTENTS
PART I
Item 1. Plan Information
Item 2. Registrant Information and Employee Plan Annual Information
PART II
Item 3. Incorporation of Documents by Reference
Item 4. Description of Securities
Item 5. Interests of Named Experts and Counsel
Item 6. Indemnification of Directors and Officers
Item 7. Exemption From Registration Claimed
Item 8. Exhibits
Item 9. Undertakings
SIGNATURES
INDEX TO EXHIBITS
EXHIBIT 5.1
EXHIBIT 23.1
Table of Contents
PART I
INFORMATION REQUIRED IN THE SECTION 10 (a) PROSPECTUS
Item 1. Plan Information.
Not required to be filed with this Registration Statement.
Item 2. Registrant Information and Employee Plan Annual Information.
Not required to be filed with this Registration Statement.
PART II
INFORMATION REQUIRED IN THE REGISTRATION STATEMENT
Item 3. Incorporation of Documents by Reference.
The following documents previously filed with the Securities and Exchange
Commission (the "SEC") by Santarus, Inc. (the "Company"), are incorporated by
reference in this Registration Statement:
(a)
the Prospectus filed by the Company pursuant to Rule
424(b) under the Securities Act of 1933, as amended (the
"Securities Act"), relating to the Registration Statement on Form
S-1, as amended (File No. 333-111515), on April 1, 2004, which
contains audited financial statements of the Company for the
latest fiscal year for which such statements have been filed; and
(b)
the description of the Company's Common Stock contained
in the Company's Registration Statement on Form 8-A filed under
Section 12(g) of the Securities Exchange Act of 1934, as amended
(the "Exchange Act"), on March 24, 2004, including any subsequent
amendment or report filed for the purpose of amending such
description.
All documents filed by the Company pursuant to Sections 13(a), 13(c), 14
or 15(d) of the Exchange Act after the date of this Registration Statement and
prior to the filing of a post-effective amendment which indicates that all
securities offered have been sold or which deregisters all securities then
remaining unsold, are incorporated by reference in this Registration Statement
and are a part hereof from the date of filing such documents. Any statement
contained in a document incorporated or deemed to be incorporated by reference
herein shall be deemed to be modified or superseded for purposes of this
Registration Statement to the extent that a statement contained herein or in
any other subsequently filed document which also is or is deemed to be
incorporated by reference herein modifies or supersedes such statement. Any
such statement so modified or superseded shall not be deemed, except as so
modified or superseded, to constitute a part of this Registration Statement.
Item 4. Description of Securities.
Not applicable.
Page 3
Table of Contents
Item 5. Interests of Named Experts and Counsel.
Not applicable.
Item 6. Indemnification of Directors and Officers.
The Company is incorporated under the laws of the State of Delaware. As
permitted by Section 102 of the Delaware General Corporation Law, the Company
has adopted provisions in its amended and restated certificate of incorporation
and amended and restated bylaws that limit or eliminate the personal liability
of the Company's directors for a breach of their fiduciary duty of care as a
director. The duty of care generally requires that, when acting on behalf of
the corporation, directors exercise an informed business judgment based on all
material information reasonably available to them. Consequently, a director
will not be personally liable to the Company or its stockholders for monetary
damages or breach of fiduciary duty as a director, except for liability for:
•
any breach of the director's duty of loyalty to the Company or its
stockholders;
•
any act or omission not in good faith or that involves
intentional misconduct or a knowing violation of law;
•
any act related to unlawful stock repurchases,
redemptions or other distributions or payment of dividends; or
•
any transaction from which the director derived an improper
personal benefit.
These limitations of liability do not affect the availability of equitable
remedies such as injunctive relief or rescission. The Company's amended and
restated certificate of incorporation also authorizes the Company to indemnify
its officers, directors and other agents to the fullest extent permitted under
Delaware law.
As permitted by Section 145 of the Delaware General Corporation Law, the
Company's bylaws provide that:
•
the Company may indemnify its directors, officers and
employees to the fullest extent permitted by the Delaware General
Corporation Law, subject to limited exceptions;
•
the Company may advance expenses to its directors,
officers and employees in connection with a legal proceeding to
the fullest extent permitted by the Delaware General Corporation
Law, subject to limited exceptions; and
•
the rights provided in the Company's bylaws are not
exclusive.
The Company's amended and restated certificate of incorporation and its
amended and restated bylaws provide for the indemnification provisions
described above. In addition, the Company has entered into separate
indemnification agreements with its directors and officers which may be broader
than the specific indemnification provisions contained in the Delaware General
Law. These indemnification agreements may require the Company, among other
things, to indemnify its
Page 4
Table of Contents
officers and directors against liabilities that may
arise by reason of their status or service as directors or officers, other than
liabilities arising from willful misconduct. These indemnification agreements
also may require the Company to advance any expenses incurred by the directors
or officers as a result of any proceeding against them as to which they could
be indemnified. In addition, the Company has purchased a policy of
directors' and officers' liability insurance that insures
our officers and directors against the cost of defense, settlement or
payment of a judgment in some circumstances.
Item 7. Exemption From Registration Claimed
.
Not applicable.
Item 8. Exhibits.
The following is a list of exhibits filed as part of this Registration
Statement, which are incorporated herein:
Exhibit
Number
Document
4.1*
Santarus, Inc. 2004 Equity Incentive Award Plan
4.2*
Santarus, Inc. 1998 Stock Option Plan
4.3*
Santarus, Inc. Employee Stock Purchase Plan
5.1**
Opinion of Latham & Watkins LLP
23.1**
Consent of Ernst & Young LLP, Independent Auditors
23.2**
Consent of Latham & Watkins LLP (contained in Exhibit 5.1)
24.1**
Power of Attorney (included in the signature page of this Registration Statement)
*
Incorporated by reference to the Company's Registration Statement on Form
S-1, as amended (File No. 333-111515).
**
Filed herewith.
Item 9. Undertakings.
(a) The undersigned registrant hereby undertakes:
(1) To file, during any period in which offers or sales are being made, a
post-effective amendment to this Registration Statement;
(i) To include any prospectus required by Section 10(a)(3) of
the Securities Act;
(ii) To reflect in the prospectus any facts or events arising
after the effective date of this Registration Statement (or the
most recent post-effective amendment thereof) which, individually
or in the aggregate, represent a fundamental change in the
information set forth in this Registration Statement.
Notwithstanding the foregoing, any increase or decrease in volume
of securities offered (if the total dollar value of securities
offered would not exceed that which was registered) and any
deviation from the low or high and of the estimated maximum
offering range may be reflected in the form of
Page 5
Table of Contents
prospectus filed
with the SEC pursuant to Rule 424(b) if, in the aggregate, the
changes in volume and price represent no more than 20 percent
change in the maximum aggregate offering price set forth in the
"Calculation of Registration Fee" table in the effective
Registration Statement;
(iii) To include any material information with respect to the
plan of distribution not previously disclosed in this Registration
Statement or any material change to such information in this
Registration Statement;
provided, however
, that the undertakings set forth in paragraphs
(a)(1)(i) and (a)(1)(ii) above do not apply if the Registration
Statement is on Form S-3, Form S-8 or Form F-3, and the information
required to be included in a post-effective amendment by those
paragraphs is contained in periodic reports filed with or furnished to
the SEC by the registrant pursuant to Section 13 or 15(d) of the
Exchange Act that are incorporated by reference in this Registration
Statement.
(2) That, for the purpose of determining any liability under the
Securities Act, each such post-effective amendment shall be deemed to be a new
registration statement relating to the securities offered therein, and the
offering of such securities at that time shall be deemed to be the initial
bona
fide
offering thereof.
(3) To remove from registration by means of a post-effective amendment any
of the securities being registered which remain unsold at the termination of
the offering.
(b) The undersigned registrant hereby undertakes that, for purposes of
determining any liability under the Securities Act, each filing of the
registrant's annual report pursuant to Section 13(a) or 15(d) of the Exchange
Act (and, where applicable, each filing of an employee benefit plan's annual
report pursuant to Section 15(d) of the Exchange Act) that is incorporated by
reference in this Registration Statement shall be deemed to be a new
registration statement relating to the securities offered therein, and the
offering of such securities at that time shall be deemed to be the initial bona
fide offering thereof.
(c) Insofar as indemnification for liabilities arising under the
Securities Act may be permitted to directors, officers and controlling persons
of the registrant pursuant to the foregoing provisions, or otherwise, the
registrant has been advised that in the opinion of the SEC such indemnification
is against public policy as expressed in the Securities Act and is, therefore,
unenforceable. In the event that a claim for indemnification against such
liabilities (other than the payment by the registrant of expenses incurred or
paid by a director, officer or controlling person of the registrant in the
successful defense of any action, suit or proceeding) is asserted by such
director, officer or controlling person in connection with the securities being
registered, the registrant will, unless in the opinion of its counsel the
matter has been settled by controlling precedent, submit to a court of
appropriate jurisdiction the question whether such indemnification by it is
against public policy as expressed in the Securities Act and will be governed
by the final adjudication of such issue.
Page 6
Table of Contents
SIGNATURES
Pursuant to the requirements of the Securities Act, the Company certifies
that it has reasonable grounds to believe that it meets all of the requirements
for filing on Form S-8 and has duly caused this Registration Statement to be
signed on its behalf by the undersigned, thereunto duly authorized, in the City
of San Diego, State of California, on this 1
st
day of April, 2004.
SANTARUS, INC.
By:
/s/ Gerald T.
Proehl
Gerald T. Proehl
President and Chief Executive Officer
POWER OF ATTORNEY
KNOW ALL PERSONS BY THESE PRESENTS, that each such person whose signature
appears below constitutes and appoints, jointly and severally, Gerald T. Proehl
and Debra P. Crawford his attorneys-in-fact, each with the power of
substitution, for him in any and all capacities, to sign any amendments to this
Registration Statement on Form S-8 (including post-effective amendments), and
to file the same, with all exhibits thereto, and other documents in connection
therewith, with the SEC, hereby ratifying and confirming all that each of said
attorneys-in-fact, or his substitute or substitutes, may do or cause to be done
by virtue hereof.
Pursuant to the requirements of the Securities Act, this Registration
Statement has been signed by the following persons in the capacities and on the
dates indicated.
Signature
Title
Date
/s/ Gerald T. Proehl
Gerald T. Proehl
President, Chief Executive
Officer and Director
(Principal Executive Officer)
April 1, 2004
/s/ Debra P. Crawford
Debra P. Crawford
Senior Vice President, Chief
Financial Officer, Treasurer
and Secretary
(Principal Financing and
Accounting Officer)
April 1, 2004
/s/ David F. Hale
David F. Hale
Chairman of the Board
April 1, 2004
/s/ Rodney A. Ferguson, J.D., Ph.D.
Rodney A. Ferguson, J.D., Ph.D.
Director
April 1, 2004
Page 7
Table of Contents
Signature
Title
Date
/s/ Maxine Gowen, Ph.D.
Maxine Gowen, Ph.D.
Director
April 1, 2004
/s/ Michael E. Herman
Michael E. Herman
Director
April 1, 2004
/s/ Arthur J. Klausner
Arthur J. Klausner
Director
April 1, 2004
/s/ Frederik Vincent van der Have
Frederik Vincent van der Have
Director
April 1, 2004
Page 8
Table of Contents
INDEX TO EXHIBITS
Exhibit
Number
Document
4.1*
Santarus, Inc. 2004 Equity Incentive Award Plan
4.2*
Santarus, Inc. 1998 Stock Option Plan
4.3*
Santarus, Inc. Employee Stock Purchase Plan
5.1**
Opinion of Latham & Watkins LLP
23.1**
Consent of Ernst & Young LLP, Independent Auditors
23.2**
Consent of Latham & Watkins LLP (contained in Exhibit 5.1)
24.1**
Power of Attorney (included in the signature page of this Registration Statement)
*
Incorporated by reference to the Company's Registration Statement on Form
S-1, as amended (File No. 333-111515).
**
Filed herewith.
Page 9