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<P align="center"><FONT size="2">As filed with the Securities and Exchange Commission on September&nbsp;20, 2002</FONT>

<P align="right"><FONT size="2">Registration No.&nbsp;333-________</FONT>

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<P align="center"><FONT size="4"><B>SECURITIES AND EXCHANGE COMMISSION</B></FONT>

<DIV align="center"><FONT size="2"><B>Washington, D.C. 20549</B></FONT></DIV>

<P align="center"><FONT size="4"><B>FORM S-8</B></FONT>

<DIV align="center"><FONT size="2"><B>REGISTRATION STATEMENT<BR>
UNDER<BR>
THE SECURITIES ACT OF 1933</B></FONT></DIV>

<P align="center"><FONT size="6"><B>Gen-Probe Incorporated</B></FONT>

<DIV align="center"><FONT size="2">(Exact name of registrant as specified in its charter)</FONT></DIV>

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        <TD align="center" valign="top"><FONT size="2"><B>Delaware</B><BR>
(State or other jurisdiction<BR>
of incorporation or organization)</FONT></TD>
        <TD><FONT size="2">&nbsp;</FONT></TD>
        <TD align="center" valign="top"><FONT size="2">
<B>33-0044608</B><BR>
(I.R.S. Employer<BR>
Identification No.)</FONT></TD>
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<P align="center"><FONT size="2"><B>10210 Genetic Center Drive<BR>
San Diego, California 92121<BR>
(858)&nbsp;410-8000</B><BR>
(Address of principal executive offices, including zip code, and telephone number)</FONT>

<P align="center"><FONT size="2"><B>2000 Equity Participation Plan of Gen-Probe Incorporated</B><BR>
(Full title of the plan)</FONT>

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        <TD align="center" valign="top"><FONT size="2"><B>Henry L. Nordhoff<BR>
Chief Executive Officer<BR>
Gen-Probe Incorporated<BR>
10210 Genetic Center Drive<BR>
San Diego, California 92121<BR>
(858)&nbsp;410-8000</B><BR>
(Name, address, including zip code, and telephone number,<BR>
including area code, of agent for service)</FONT></TD>
        <TD><FONT size="2">&nbsp;</FONT></TD>
        <TD align="center" valign="top"><FONT size="2">
Copies to:<BR>
<B>Scott N. Wolfe, Esq.<BR>
Latham &#038; Watkins<BR>
12636 High Bluff Drive, Suite&nbsp;300<BR>
San Diego, California 92130<BR>
(858)&nbsp;523-5400</B></FONT></TD>
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<P align="center"><FONT size="2"><B>CALCULATION OF REGISTRATION FEE</B></FONT>

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        <TD width="7%"></TD>
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        <TD width="8%"></TD>
        <TD width="3%"></TD>
        <TD width="5%"></TD>
        <TD width="1%"></TD>
        <TD width="6%"></TD>
        <TD width="3%"></TD>
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        <TD width="6%"></TD>
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        <TD><FONT size="1">&nbsp;</FONT></TD>
        <TD><FONT size="1">&nbsp;</FONT></TD>
        <TD nowrap align="center" colspan="3"><FONT size="1">Amount</FONT></TD>
        <TD><FONT size="1">&nbsp;</FONT></TD>
        <TD nowrap align="center" colspan="3"><FONT size="1">Proposed Maximum</FONT></TD>
        <TD><FONT size="1">&nbsp;</FONT></TD>
        <TD nowrap align="center" colspan="3"><FONT size="1">Proposed Maximum</FONT></TD>
        <TD><FONT size="1">&nbsp;</FONT></TD>
        <TD nowrap align="center" colspan="3"><FONT size="1">Amount of</FONT></TD>
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<TR valign="bottom">
        <TD nowrap align="center"><FONT size="1">Title of Securities</FONT></TD>
        <TD><FONT size="1">&nbsp;</FONT></TD>
        <TD nowrap align="center" colspan="3"><FONT size="1">to be</FONT></TD>
        <TD><FONT size="1">&nbsp;</FONT></TD>
        <TD nowrap align="center" colspan="3"><FONT size="1">Offering Price</FONT></TD>
        <TD><FONT size="1">&nbsp;</FONT></TD>
        <TD nowrap align="center" colspan="3"><FONT size="1">Aggregate</FONT></TD>
        <TD><FONT size="1">&nbsp;</FONT></TD>
        <TD nowrap align="center" colspan="3"><FONT size="1">Registration</FONT></TD>
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        <TD nowrap align="center"><FONT size="1">to be Registered</FONT></TD>
        <TD><FONT size="1">&nbsp;</FONT></TD>
        <TD nowrap align="center" colspan="3"><FONT size="1">Registered(1)</FONT></TD>
        <TD><FONT size="1">&nbsp;</FONT></TD>
        <TD nowrap align="center" colspan="3"><FONT size="1">Per Share</FONT></TD>
        <TD><FONT size="1">&nbsp;</FONT></TD>
        <TD nowrap align="center" colspan="3"><FONT size="1">Offering Price</FONT></TD>
        <TD><FONT size="1">&nbsp;</FONT></TD>
        <TD nowrap align="center" colspan="3"><FONT size="1">Fee</FONT></TD>
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        <TD><DIV style="margin-left:10px; text-indent:-10px"><FONT size="2">Common Stock, $.0001 par value</FONT></DIV></TD>
        <TD><FONT size="2">&nbsp;</FONT></TD>
        <TD><FONT size="2">&nbsp;</FONT></TD>
        <TD align="right"><FONT size="2">2,413,973</FONT></TD>
        <TD><FONT size="2">&nbsp;</FONT></TD>
        <TD><FONT size="2">&nbsp;</FONT></TD>
        <TD colspan="3" align="center"><FONT size="2">$(2)</FONT></TD>
        <TD><FONT size="2">&nbsp;</FONT></TD>
        <TD align="right"><FONT size="2">$</FONT></TD>
        <TD align="right"><FONT size="2">63,605,787</FONT></TD>
        <TD><FONT size="2">&nbsp;</FONT></TD>
        <TD><FONT size="2">&nbsp;</FONT></TD>
        <TD colspan="3" align="center"><FONT size="2">$5,852</FONT></TD>
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<P>
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      <TD width="1%" align="left" nowrap><FONT size="2">(1)</FONT></TD>
        <TD width="3%"><FONT size="2">&nbsp;</FONT></TD>
        <TD width="96%"><FONT size="2">Pursuant to Rule&nbsp;416(a), this Registration Statement shall also cover
any additional shares of the Registrant&#146;s Common Stock that become
issuable by reason of any stock dividend, stock split, recapitalization or
other similar transaction effected without receipt of consideration that
increases the number of the Registrant&#146;s outstanding shares of common
stock.</FONT></TD>
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<TR><TD><TR><TD><TR><TD><TR><TD>
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      <TD width="1%" align="left" nowrap><FONT size="2">(2)</FONT></TD>
        <TD width="3%"><FONT size="2">&nbsp;</FONT></TD>
        <TD width="96%"><FONT size="2">This estimate is made pursuant to Rule&nbsp;457(h) solely for the purpose of
calculating the registration fee, and is determined according to the
following offering price information: of the 2,413,973 shares of Common
Stock reserved for issuance under the 2000 Equity Participation Plan of
Gen-Probe Incorporated (the &#147;2000 Plan&#148;) being registered hereunder, (i)
1,960,170 shares of Common Stock are subject to outstanding options with
an exercise price of $27.31 per share, (ii)&nbsp;353,571 shares of Common Stock
are subject to outstanding options with an exercise price of $24.58 per
share, (iii) 50,000 shares of Common Stock are subject to outstanding options with an exercise price of $13.50 per share and (iv)&nbsp;50,232 shares of Common Stock are reserved for issuance
upon exercise of options to be granted in the future. Pursuant to Rule
457(h), for all shares of Common Stock being registered hereunder with an
exercise price which cannot be presently determined (50,232 shares), the
Proposed Maximum Offering Price Per Share is $14.09 per share of
Common Stock, which is based on the average of the high and low prices for
the Common Stock as reported on the Nasdaq National Market on September
18, 2002.</FONT></TD>
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<P align="center"><FONT size="2">&nbsp;
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<A name="toc"><DIV align="CENTER" style="page-break-before:always"><U><B>TABLE OF CONTENTS</B></U></DIV></A>

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<TR><TD colspan="9"><A HREF="#000">Part I</A></TD></TR>
<TR><TD></TD><TD colspan="8"><A HREF="#001">Item&nbsp;1. Plan Information.</A></TD></TR>
<TR><TD></TD><TD colspan="8"><A HREF="#002">Item&nbsp;2. Registrant Information and Employee Plan Annual Information.</A></TD></TR>
<TR><TD colspan="9"><A HREF="#003">Part II</A></TD></TR>
<TR><TD></TD><TD colspan="8"><A HREF="#004">Item&nbsp;3. Incorporation of Documents by Reference.</A></TD></TR>
<TR><TD></TD><TD colspan="8"><A HREF="#005">Item&nbsp;4. Description of Securities.</A></TD></TR>
<TR><TD></TD><TD colspan="8"><A HREF="#006">Item&nbsp;5. Interests of Named Experts and Counsel.</A></TD></TR>
<TR><TD></TD><TD colspan="8"><A HREF="#007">Item&nbsp;6. Indemnification of Directors and Officers.</A></TD></TR>
<TR><TD></TD><TD colspan="8"><A HREF="#008">Item&nbsp;7. Exemption from Registration Claimed.</A></TD></TR>
<TR><TD></TD><TD colspan="8"><A HREF="#009">Item&nbsp;8. Exhibits.</A></TD></TR>
<TR><TD></TD><TD colspan="8"><A HREF="#010">Item&nbsp;9. Undertakings.</A></TD></TR>
<TR><TD colspan="9"><A HREF="#011">SIGNATURES</A></TD></TR>
<TR><TD colspan="9"><A HREF="#012">EXHIBIT INDEX</A></TD></TR>
<TR><TD colspan="9"><A HREF="a84474orexv5w1.txt">EXHIBIT 5.1</A></TD></TR>
<TR><TD colspan="9"><A HREF="a84474orexv23w1.txt">EXHIBIT 23.1</A></TD></TR>
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<!-- link1 "Part I" -->
<DIV align="left"><A NAME="000"></A></DIV>
<P align="center"><FONT size="2"><B>Part I</B></FONT>

<!-- link2 "Item&nbsp;1. Plan Information." -->
<DIV align="left"><A NAME="001"></A></DIV>
<P align="left"><FONT size="2"><B>Item&nbsp;1. Plan Information.</B></FONT>

<P><FONT size="2">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Not required to be filed with this Registration Statement.
</FONT>
<!-- link2 "Item&nbsp;2. Registrant Information and Employee Plan Annual Information." -->
<DIV align="left"><A NAME="002"></A></DIV>
<P align="left"><FONT size="2"><B>Item&nbsp;2. Registrant Information and Employee Plan Annual Information.</B></FONT>

<P><FONT size="2">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Not required to be filed with this Registration Statement.
</FONT>
<!-- link1 "Part II" -->
<DIV align="left"><A NAME="003"></A></DIV>
<P align="center"><FONT size="2"><B>Part II</B></FONT>

<!-- link2 "Item&nbsp;3. Incorporation of Documents by Reference." -->
<DIV align="left"><A NAME="004"></A></DIV>
<P align="left"><FONT size="2"><B>Item&nbsp;3. Incorporation of Documents by Reference.</B></FONT>

<P><FONT size="2">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;The Securities and Exchange Commission (the &#147;Commission&#148;) allows us to
incorporate by reference the information we file with it, which means that we
can disclose important information to you by referring to those documents. The
information incorporated by reference is an important part of this Registration
Statement, and information that we file later with the Commission will
automatically update and supersede this information. We incorporate by
reference the following documents we have filed, or may file, with the
Commission:
</FONT>
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   <TD width="1%" nowrap><FONT size="2">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</FONT></TD>
   <TD width="1%" align="left"><FONT size="2">&#149;</FONT></TD>
   <TD width="1%" nowrap><FONT size="2">&nbsp;&nbsp;</FONT></TD>
   <TD width="97%"><FONT size="2">Our Registration Statement on Form&nbsp;10, as amended (the &#147;Form
10&#148;) (File No.&nbsp;0-49834) filed under the Securities Exchange Act of
1934, as amended (the &#147;Exchange Act&#148;), which contains audited
financial statements for our latest fiscal year;</FONT></TD>
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        <TD><FONT size="2">&nbsp;</FONT></TD>
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   <TD width="1%" nowrap><FONT size="2">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</FONT></TD>
   <TD width="1%" align="left"><FONT size="2">&#149;</FONT></TD>
   <TD width="1%" nowrap><FONT size="2">&nbsp;&nbsp;</FONT></TD>
   <TD width="97%"><FONT size="2">Our Quarterly Report on Form&nbsp;10-Q for the quarter ended June
30, 2002 filed with the Commission on August&nbsp;27, 2002;</FONT></TD>
</TR>
<TR>
        <TD><FONT size="2">&nbsp;</FONT></TD>
</TR>
<TR valign="top">
   <TD width="1%" nowrap><FONT size="2">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</FONT></TD>
   <TD width="1%" align="left"><FONT size="2">&#149;</FONT></TD>
   <TD width="1%" nowrap><FONT size="2">&nbsp;&nbsp;</FONT></TD>
   <TD width="97%"><FONT size="2">Our Current Report on Form&nbsp;8-K filed with the Commission on September&nbsp;11, 2002;</FONT></TD>
</TR>
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        <TD><FONT size="2">&nbsp;</FONT></TD>
</TR>

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   <TD width="1%" nowrap><FONT size="2">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</FONT></TD>
   <TD width="1%" align="left"><FONT size="2">&#149;</FONT></TD>
   <TD width="1%" nowrap><FONT size="2">&nbsp;&nbsp;</FONT></TD>
   <TD width="97%"><FONT size="2">Our Current Report on Form&nbsp;8-K filed with the Commission on September&nbsp;17, 2002;</FONT></TD>
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        <TD><FONT size="2">&nbsp;</FONT></TD>
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<TR valign="top">
   <TD width="1%" nowrap><FONT size="2">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</FONT></TD>
   <TD width="1%" align="left"><FONT size="2">&#149;</FONT></TD>
   <TD width="1%" nowrap><FONT size="2">&nbsp;&nbsp;</FONT></TD>
   <TD width="97%"><FONT size="2">The description of our common stock contained in the Form&nbsp;10; and</FONT></TD>
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<TR>
        <TD><FONT size="2">&nbsp;</FONT></TD>
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   <TD width="1%" nowrap><FONT size="2">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</FONT></TD>
   <TD width="1%" align="left"><FONT size="2">&#149;</FONT></TD>
   <TD width="1%" nowrap><FONT size="2">&nbsp;&nbsp;</FONT></TD>
   <TD width="97%"><FONT size="2">All documents filed by us with the Commission under Sections
13(a), 13(c), 14 or 15(d) of the Exchange Act after the date this
Registration Statement is filed with the Commission and prior to the
filing of a post-effective amendment which indicates that all
securities offered have been sold or which deregisters all
securities then remaining unsold shall be deemed to be incorporated
by reference in this Registration Statement and to be a part of it
from the respective dates of filing of those documents.</FONT></TD>
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<P><FONT size="2">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;A statement contained in a document incorporated by reference herein shall
be deemed to be modified or superseded for purposes of this Registration
Statement to the extent that a statement contained herein or in any other
subsequently filed document which is also incorporated herein modifies or
replaces such statement. Any statements so modified or superceded shall not be
deemed, except as so modified or superceded, to constitute a part of this
Registration Statement.
</FONT>
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<DIV align="left"><A NAME="005"></A></DIV>
<P align="left"><FONT size="2"><B>Item&nbsp;4. Description of Securities</B>.</FONT>

<P><FONT size="2">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Not applicable.
</FONT>
<P align="center"><FONT size="2">1
</FONT>

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<!-- link2 "Item&nbsp;5. Interests of Named Experts and Counsel." -->
<DIV align="left"><A NAME="006"></A></DIV>
<P align="left"><FONT size="2"><B>Item&nbsp;5. Interests of Named Experts and Counsel.</B></FONT>

<P><FONT size="2">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Not applicable.
</FONT>
<!-- link2 "Item&nbsp;6. Indemnification of Directors and Officers." -->
<DIV align="left"><A NAME="007"></A></DIV>
<P align="left"><FONT size="2"><B>Item&nbsp;6. Indemnification of Directors and Officers.</B></FONT>

<P><FONT size="2">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Section&nbsp;145 of the Delaware General Corporation Law provides that a
corporation may indemnify any current or former director, officer or employee
or other individual against expenses, judgments, fines and amounts paid in
settlement in connection with civil, criminal, administrative or investigative
actions or proceedings, other than a derivative action by or in the right of
the corporation, if the director, officer, employee or other individual acted
in good faith and in a manner he or she reasonably believed to be in or not
opposed to the best interests of the corporation, and, with respect to any
criminal action or proceeding, if he or she had no reasonable cause to believe
his or her conduct was unlawful. A similar standard is applicable in the case
of derivative actions, except that indemnification only extends to expenses
incurred in connection with the defense or settlement of such actions, and the
statute requires court approval before there can be any indemnification where
the person seeking indemnification has been found liable to the corporation.
The statute provides that it is not exclusive of other indemnification that may
be granted by a corporation&#146;s bylaws, disinterested director vote, stockholder
vote, agreement or otherwise.
</FONT>
<P><FONT size="2">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Our certificate of incorporation provides that each person who was or is
made or is threatened to be made a party to any action or proceeding by reason
of the fact that such person, or a person of whom such person is the legal
representative, is or was a director or officer of us or is or was serving at
our request as a director or officer of another corporation or of a
partnership, joint venture, trust or other enterprise, including service with
respect to employee benefit plans, will be indemnified and held harmless by us
to the fullest extent authorized by the Delaware General Corporation Law, as
the same exists or may hereafter be amended. Such rights are not exclusive of
any other right which any person may have or thereafter acquire under any
statute, provision of the certificate, bylaw, agreement, vote of stockholders
or disinterested directors or otherwise. Our certificate of incorporation also
specifically authorizes us to maintain insurance and to grant similar
indemnification rights to our employees or agents. We have extended similar
indemnification rights to our employees and agents pursuant to our bylaws.
</FONT>
<P><FONT size="2">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;We also intend to enter into indemnification agreements with each of our
directors and executive officers that provide for mandatory indemnification of
an officer or director made party to a &#147;proceeding&#148; by reason of the fact that
he or she is or was an officer or director of ours, if he or she acted in good
faith and in a manner he or she reasonably believed to be in or not opposed to
our best interests. These agreements also obligate us to advance expenses to an
indemnitee provided that he or she agrees to repay advanced expenses in the
event he or she is not entitled to indemnification. Indemnitees are also
entitled to partial indemnification, and indemnification for expenses incurred
as a result of acting at our request as a director, officer or agent of an
employee benefit plan or other partnership, corporation, joint venture, trust
or other enterprise owned or controlled by us.
</FONT>
<P><FONT size="2">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Insofar as indemnification for liabilities arising under the Securities
Act of 1933, as amended (the &#147;Securities Act&#148;), may be permitted to our
directors, officers and controlling persons pursuant to the above statutory
provisions or otherwise, we have been advised that, in the opinion of the
Commission, indemnification is against public policy as expressed in the
Securities Act and is, therefore, unenforceable.
</FONT>
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<DIV align="left"><A NAME="008"></A></DIV>
<P align="left"><FONT size="2"><B>Item&nbsp;7. Exemption from Registration Claimed.</B></FONT>

<P><FONT size="2">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Not applicable.
</FONT>
<P align="center"><FONT size="2">2
</FONT>

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<!-- link2 "Item&nbsp;8. Exhibits." -->
<DIV align="left"><A NAME="009"></A></DIV>
<P align="left"><FONT size="2"><B>Item&nbsp;8. Exhibits.</B></FONT>

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        <TD width="4%">&nbsp;</TD>
        <TD width="1%">&nbsp;</TD>
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        <TD nowrap align="center" colspan="2"><FONT size="1">Exhibit</FONT></TD>
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        <TD nowrap align="center" colspan="2"><FONT size="1">Number</FONT></TD>
        <TD><FONT size="1">&nbsp;</FONT></TD>
        <TD nowrap align="center"><FONT size="1">Description of Exhibit</FONT></TD>
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        <TD valign="top" align="right"><FONT size="2">4.</FONT></TD>
        <TD align="left" valign="top"><FONT size="2">
1(1)
</FONT></TD>
        <TD><FONT size="2">&nbsp;</FONT></TD>
        <TD align="left" valign="top"><FONT size="2">Specimen common stock certificate</FONT></TD>
</TR>

<TR valign="bottom">
        <TD valign="top" align="right"><FONT size="2">4.</FONT></TD>
        <TD align="left" valign="top" nowrap><FONT size="2">
2(1)
</FONT></TD>
        <TD><FONT size="2">&nbsp;</FONT></TD>
        <TD align="left" valign="top"><FONT size="2">2000 Equity Participation Plan of Gen-Probe Incorporated</FONT></TD>
</TR>

<TR valign="bottom">
        <TD valign="top" align="right"><FONT size="2">5.</FONT></TD>
        <TD align="left" valign="top"><FONT size="2">
1*
</FONT></TD>
        <TD><FONT size="2">&nbsp;</FONT></TD>
        <TD align="left" valign="top"><FONT size="2">Opinion of Latham &#038; Watkins</FONT></TD>
</TR>

<TR valign="bottom">
        <TD valign="top" align="right"><FONT size="2">23.</FONT></TD>
        <TD align="left" valign="top"><FONT size="2">
1*
</FONT></TD>
        <TD><FONT size="2">&nbsp;</FONT></TD>
        <TD align="left" valign="top"><FONT size="2">Consent of Ernst &#038; Young, LLP, independent auditors</FONT></TD>
</TR>

<TR valign="bottom">
        <TD valign="top" align="right"><FONT size="2">23.</FONT></TD>
        <TD align="left" valign="top"><FONT size="2">
2*
</FONT></TD>
        <TD><FONT size="2">&nbsp;</FONT></TD>
        <TD align="left" valign="top"><FONT size="2">Consent of Latham &#038; Watkins (reference is made to Exhibit&nbsp;5.1)</FONT></TD>
</TR>

<TR valign="bottom">
        <TD valign="top" align="right"><FONT size="2">24.</FONT></TD>
        <TD align="left" valign="top"><FONT size="2">
1*
</FONT></TD>
        <TD valign="top"><FONT size="2">&nbsp;</FONT></TD>
        <TD align="left" valign="top"><FONT size="2">Power of Attorney (included in signature page)</FONT></TD>
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<P>
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<TABLE width="100%" border="0" cellpadding="0" cellspacing="0">
<TR valign="top">
      <TD width="1%" align="left" nowrap><FONT size="2">*</FONT></TD>
        <TD width="3%"><FONT size="2">&nbsp;</FONT></TD>
        <TD width="96%"><FONT size="2">Filed herewith.</FONT></TD>
</TR>
<TR><TD><TR><TD><TR><TD><TR><TD>
<TR valign="top">
      <TD width="1%" align="left" nowrap><FONT size="2">(1)</FONT></TD>
        <TD width="3%"><FONT size="2">&nbsp;</FONT></TD>
        <TD width="96%"><FONT size="2">Filed as an exhibit to the Registrant&#146;s Registration Statement on Form
10, as amended (File No.&nbsp;0-49834), and incorporated herein by reference.</FONT></TD>
</TR>
</TABLE>
<!-- link2 "Item&nbsp;9. Undertakings." -->
<DIV align="left"><A NAME="010"></A></DIV>
<P align="left"><FONT size="2"><B>Item&nbsp;9. Undertakings.</B></FONT>

<P><FONT size="2">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(a)&nbsp; The undersigned Registrant hereby undertakes:
</FONT>
<P align="left"><FONT size="2">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(1)&nbsp;To file, during any period in which offers or sales are being made, a
post-effective amendment to this Registration Statement;
</FONT>

<TABLE width="100%" border="0" cellpadding="0" cellspacing="0">
<TR>
        <TD width="1%" nowrap>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</TD>
        <TD width="99%"></TD>
</TR>
<TR valign="top">
        <TD nowrap><FONT size="2">&nbsp;</FONT></TD>
        <TD><FONT size="2">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(i)&nbsp;To include any prospectus required by Section&nbsp;10(a)(3) of
the Securities Act;</FONT></TD>
</TR>
<TR>
        <TD nowrap><FONT size="2">&nbsp;</FONT></TD>
</TR>
<TR valign="top">
        <TD nowrap><FONT size="2">&nbsp;</FONT></TD>
        <TD><FONT size="2">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(ii)&nbsp;To reflect in the prospectus any facts or events arising
after the effective date of this Registration Statement (or the
most recent post-effective amendment thereof) which, individually
or in the aggregate, represent a fundamental change in the
information set forth in this Registration Statement.
Notwithstanding the foregoing, any increase or decrease in volume
of securities offered (if the total dollar value of securities
offered would not exceed that which was registered) and any
deviation from the low or high and of the estimated maximum
offering range may be reflected in the form of prospectus filed
with the Commission pursuant to Rule&nbsp;424(b) if, in the aggregate,
the changes in volume and price represent no more than 20&nbsp;percent
change in the maximum aggregate offering price set forth in the
&#147;Calculation of Registration Fee&#148; table in the effective
Registration Statement;</FONT></TD>
</TR>
<TR>
        <TD nowrap><FONT size="2">&nbsp;</FONT></TD>
</TR>
<TR valign="top">
        <TD nowrap><FONT size="2">&nbsp;</FONT></TD>
        <TD><FONT size="2">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(iii)&nbsp;To include any material information with respect to the
plan of distribution not previously disclosed in this Registration
Statement or any material change to such information in this
Registration Statement;</FONT></TD>
</TR>
</TABLE>
<P><FONT size="2"><I>provided, however</I>, that the undertakings set forth in paragraphs (a)(1)(i) and
(a)(1)(ii) above do not apply if the Registration Statement is on Form&nbsp;S-3,
Form&nbsp;S-8 or Form&nbsp;F-3, and the information required to be included in a
post-effective amendment by those paragraphs is contained in periodic reports
filed with or furnished to the Commission by the Registrant pursuant to Section
13 or 15(d) of the Exchange Act that are incorporated by reference in this
Registration Statement.
</FONT>
<P align="left"><FONT size="2">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(2)&nbsp;That, for the purpose of determining any liability under the
Securities Act, each such post-effective amendment shall be deemed to be a new
registration statement relating to the securities offered therein, and the
offering of such securities at that time shall be deemed to be the initial <I>bona
fide </I>offering thereof.
</FONT>

<P align="center"><FONT size="2">3
</FONT>

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<H5 align="left" style="page-break-before:always"><A HREF="#toc">Table of Contents</A></H5><P>


<P align="left"><FONT size="2">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(3)&nbsp;To remove from registration by means of a post-effective amendment any
of the securities being registered which remain unsold at the termination of
the offering.
</FONT>

<P><FONT size="2">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(b)&nbsp; The undersigned Registrant hereby undertakes that, for purposes of
determining any liability under the Securities Act, each filing of the
Registrant&#146;s annual report pursuant to Section&nbsp;13(a) or
15(d) of the Exchange Act (and, where applicable, each filing of an employee
benefit plan&#146;s annual report pursuant to Section&nbsp;15(d) of the Exchange Act)
that is incorporated by reference in this Registration Statement shall be
deemed to be a new registration statement relating to the securities offered
therein, and the offering of such securities at that time shall be deemed to be
the initial bona fide offering thereof.
</FONT>
<P><FONT size="2">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(c)&nbsp; Insofar as indemnification for liabilities arising under the
Securities Act may be permitted to directors, officers and controlling persons
of the Registrant pursuant to the foregoing provisions, or otherwise, the
Registrant has been advised that in the opinion of the Commission such
indemnification is against public policy as expressed in the Securities Act and
is, therefore, unenforceable. In the event that a claim for indemnification
against such liabilities (other than the payment by the Registrant of expenses
incurred or paid by a director, officer or controlling person of the Registrant
in the successful defense of any action, suit or proceeding) is asserted by
such director, officer or controlling person in connection with the securities
being registered, the Registrant will, unless in the opinion of its counsel the
matter has been settled by controlling precedent, submit to a court of
appropriate jurisdiction the question whether such indemnification by it is
against public policy as expressed in the Securities Act and will be governed
by the final adjudication of such issue.
</FONT>
<P align="center"><FONT size="2">4
</FONT>

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<P><HR noshade><P>
<H5 align="left" style="page-break-before:always"><A HREF="#toc">Table of Contents</A></H5><P>
<!-- link1 "SIGNATURES" -->
<DIV align="left"><A NAME="011"></A></DIV>
<P align="center"><FONT size="2"><B>SIGNATURES</B></FONT>

<P><FONT size="2">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Pursuant to the requirements of the Securities Act, the Registrant
certifies that it has reasonable grounds to believe that it meets all of the
requirements for filing on Form&nbsp;S-8, and has duly caused this Registration
Statement to be signed on its behalf by the undersigned, thereunto duly
authorized, in the City of San Diego, County of San Diego, State of California,
on this 19th day of September, 2002.
</FONT>
<TABLE cellspacing="0" border="0" cellpadding="0" width="100%">
<TR>
        <TD width="50%">&nbsp;</TD>
        <TD width="1%">&nbsp;</TD>
        <TD width="49%">&nbsp;</TD>
</TR>
<TR>
        <TD><FONT size="2">&nbsp;</FONT></TD>
        <TD><FONT size="2">By:&nbsp;</FONT></TD>
        <TD><FONT size="2">/s/ Henry L. Nordhoff</FONT></TD>
</TR>
<TR>
        <TD colspan="2"><FONT size="1">&nbsp;</FONT></TD>
        <TD><HR size="1" noshade color="#000000"></TD>
</TR>
<TR valign="top">
        <TD colspan="2">&nbsp;</TD>
        <TD><FONT size="2">
Henry L. Nordhoff<BR>
<I>President and Chief Executive
Officer</I></FONT></TD>
</TR>
</TABLE>

<P align="center"><FONT size="2"><B>POWER OF ATTORNEY</B></FONT>

<P><FONT size="2">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;KNOW ALL PERSONS BY THESE PRESENTS, that each person whose signature
appears below constitutes and appoints Henry L. Nordhoff and Herm Rosenman and
each of them, as his true and lawful attorneys-in-fact and agents, with full
power of substitution and resubstitution, for him and in his name, place, and
stead, in any and all capacities, to sign any and all amendments (including
post-effective amendments, exhibits thereto and other documents in connection
therewith) to this Registration Statement and any subsequent registration
statement filed by the Registrant pursuant to Rule&nbsp;462(b) of the Securities
Act, which relates to this Registration Statement, and to file the same, with
all exhibits thereto, and other documents in connection therewith, with the
Commission, granting unto said attorneys-in-fact and agents, and each of them,
full power and authority to do and perform each and every act and thing
requisite and necessary to be done in connection therewith, as fully to all
intents and purposes as he might or could do in person, hereby ratifying and
confirming all that said attorney-in-fact and agents, or any of them, or their
or his substitute or substitutes, may lawfully do or cause to be done by virtue
hereof.
</FONT>
<P><FONT size="2">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Pursuant to the requirements of the Securities Act, this Registration
Statement has been signed by the following persons in the capacities and on the
date indicated.
</FONT>
<CENTER>
<TABLE cellspacing="0" border="0" cellpadding="0" width="100%">
<TR valign="bottom">
        <TD width="40%">&nbsp;</TD>
        <TD width="5%">&nbsp;</TD>
        <TD width="33%">&nbsp;</TD>
        <TD width="5%">&nbsp;</TD>
        <TD width="17%">&nbsp;</TD>
</TR>
<TR valign="bottom">
        <TD nowrap align="center"><FONT size="1"><B>Signature</B></FONT></TD>
        <TD><FONT size="1">&nbsp;</FONT></TD>
        <TD nowrap align="center"><FONT size="1"><B>Title</B></FONT></TD>
        <TD><FONT size="1">&nbsp;</FONT></TD>
        <TD nowrap align="center"><FONT size="1"><B>Date</B></FONT></TD>
</TR>
<TR valign="bottom">
        <TD nowrap align="center"><HR size="1" noshade></TD>
        <TD><FONT size="1">&nbsp;</FONT></TD>
        <TD nowrap align="center"><HR size="1" noshade></TD>
        <TD><FONT size="1">&nbsp;</FONT></TD>
        <TD nowrap align="center"><HR size="1" noshade></TD>
</TR>
<TR valign="bottom">
        <TD valign="top" align="center"><FONT size="2">/s/ Henry L. Nordhoff<BR>
</FONT><HR size="1" noshade><FONT size="2">
Henry L. Nordhoff</FONT></TD>
        <TD><FONT size="2">&nbsp;</FONT></TD>
        <TD align="center" valign="top"><FONT size="2">
President, Chief Executive<BR>
Officer and Director<BR>
(Principal Executive Officer)
</FONT></TD>
        <TD><FONT size="2">&nbsp;</FONT></TD>
        <TD align="center" valign="top"><FONT size="2">September 19, 2002</FONT></TD>
</TR>
<TR><TD><FONT size="2">&nbsp;</FONT></TD></TR>
<TR valign="bottom">
        <TD valign="top" align="center"><FONT size="2">/s/ Herm Rosenman<BR>
</FONT><HR size="1" noshade><FONT size="2">
Herm Rosenman</FONT></TD>
        <TD><FONT size="2">&nbsp;</FONT></TD>
        <TD align="center" valign="top"><FONT size="2">
Vice President &#150; Finance<BR>
and Chief Financial Officer<BR>
(Principal Financial Officer<BR>
and Principal Accounting<BR>
Officer)
</FONT></TD>
        <TD><FONT size="2">&nbsp;</FONT></TD>
        <TD align="center" valign="top"><FONT size="2">September 19, 2002</FONT></TD>
</TR>
<TR><TD><FONT size="2">&nbsp;</FONT></TD></TR>
<TR valign="bottom">
        <TD valign="top" align="center"><FONT size="2">/s/ Raymond V. Dittamore<BR>
</FONT><HR size="1" noshade><FONT size="2">
Raymond V. Dittamore</FONT></TD>
        <TD><FONT size="2">&nbsp;</FONT></TD>
        <TD align="center" valign="top"><FONT size="2">
Director
</FONT></TD>
        <TD><FONT size="2">&nbsp;</FONT></TD>
        <TD align="center" valign="top"><FONT size="2">September 19, 2002</FONT></TD>
</TR>
<TR><TD><FONT size="2">&nbsp;</FONT></TD></TR>
<TR valign="bottom">
        <TD valign="top" align="center"><FONT size="2">/s/ Kiyoshi Kurokawa, M.D., MACP<BR>
</FONT><HR size="1" noshade><FONT size="2">
Kiyoshi Kurokawa, M.D., MACP</FONT></TD>
        <TD><FONT size="2">&nbsp;</FONT></TD>
        <TD align="center" valign="top"><FONT size="2">
Director
</FONT></TD>
        <TD><FONT size="2">&nbsp;</FONT></TD>
        <TD align="center" valign="top"><FONT size="2">September 19, 2002</FONT></TD>
</TR>
<TR><TD><FONT size="2">&nbsp;</FONT></TD></TR>
<TR valign="bottom">
        <TD valign="top" align="center"><FONT size="2">/s/ Gerald D. Laubach, Ph.D.<BR>
</FONT><HR size="1" noshade><FONT size="2">
Gerald D. Laubach, Ph.D.</FONT></TD>
        <TD><FONT size="2">&nbsp;</FONT></TD>
        <TD align="center" valign="top"><FONT size="2">
Director
</FONT></TD>
        <TD><FONT size="2">&nbsp;</FONT></TD>
        <TD align="center" valign="top"><FONT size="2">September 20, 2002</FONT></TD>
</TR>
<TR><TD><FONT size="2">&nbsp;</FONT></TD></TR>
<TR valign="bottom">
        <TD valign="top" align="center"><FONT size="2">/s/ Brian A. McNamee, M.B.<BR>
</FONT><HR size="1" noshade><FONT size="2">
Brian A. McNamee, M.B.</FONT></TD>
        <TD><FONT size="2">&nbsp;</FONT></TD>
        <TD align="center" valign="top"><FONT size="2">
Director
</FONT></TD>
        <TD><FONT size="2">&nbsp;</FONT></TD>
        <TD align="center" valign="top"><FONT size="2">September 16, 2002</FONT></TD>
</TR>
</TABLE>
</CENTER>
<P align="center"><FONT size="2">&nbsp;
</FONT>

<!-- PAGEBREAK -->
<P><HR noshade><P>
<H5 align="left" style="page-break-before:always"><A HREF="#toc">Table of Contents</A></H5><P>
<CENTER>
<TABLE cellspacing="0" border="0" cellpadding="0" width="100%">
<TR valign="bottom">
        <TD width="40%">&nbsp;</TD>
        <TD width="5%">&nbsp;</TD>
        <TD width="33%">&nbsp;</TD>
        <TD width="5%">&nbsp;</TD>
        <TD width="17%">&nbsp;</TD>
</TR>
<TR valign="bottom">
        <TD nowrap align="center"><FONT size="1"><B>Signature</B></FONT></TD>
        <TD><FONT size="1">&nbsp;</FONT></TD>
        <TD nowrap align="center"><FONT size="1"><B>Title</B></FONT></TD>
        <TD><FONT size="1">&nbsp;</FONT></TD>
        <TD nowrap align="center"><FONT size="1"><B>Date</B></FONT></TD>
</TR>
<TR valign="bottom">
        <TD nowrap align="center"><HR size="1" noshade></TD>
        <TD><FONT size="1">&nbsp;</FONT></TD>
        <TD nowrap align="center"><HR size="1" noshade></TD>
        <TD><FONT size="1">&nbsp;</FONT></TD>
        <TD nowrap align="center"><HR size="1" noshade></TD>
</TR>
<TR><TD><FONT size="2">&nbsp;</FONT></TD></TR>
<TR valign="bottom">
        <TD valign="top" align="center"><FONT size="2">/s/ Abraham D. Sofaer<BR>
</FONT><HR size="1" noshade><FONT size="2">
Abraham D. Sofaer</FONT></TD>
        <TD><FONT size="2">&nbsp;</FONT></TD>
        <TD align="center" valign="top"><FONT size="2">
Director
</FONT></TD>
        <TD><FONT size="2">&nbsp;</FONT></TD>
        <TD align="center" valign="top"><FONT size="2">September 19, 2002</FONT></TD>
</TR>
</TABLE>
</CENTER>
<P align="center"><FONT size="2">&nbsp;
</FONT>

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<P><HR noshade><P>
<H5 align="left" style="page-break-before:always"><A HREF="#toc">Table of Contents</A></H5><P>
<!-- link1 "EXHIBIT INDEX" -->
<DIV align="left"><A NAME="012"></A></DIV>
<P align="center"><FONT size="2"><B>EXHIBIT INDEX</B></FONT>

<CENTER>
<TABLE cellspacing="0" border="0" cellpadding="0" width="85%">
<TR valign="bottom">
        <TD width="4%">&nbsp;</TD>
        <TD width="1%">&nbsp;</TD>
        <TD width="5%">&nbsp;</TD>
        <TD width="90%">&nbsp;</TD>
</TR>


<TR valign="bottom">
        <TD nowrap align="center" colspan="2"><FONT size="1">Exhibit</FONT></TD>
        <TD><FONT size="1">&nbsp;</FONT></TD>
        <TD><FONT size="1">&nbsp;</FONT></TD>
</TR>
<TR valign="bottom">
        <TD nowrap align="center" colspan="2"><FONT size="1">Number</FONT></TD>
        <TD><FONT size="1">&nbsp;</FONT></TD>
        <TD nowrap align="center"><FONT size="1">Description of Exhibit</FONT></TD>
</TR>
<TR valign="bottom">
        <TD colspan="2"><HR size="1" noshade></TD>
        <TD><FONT size="1">&nbsp;</FONT></TD>
        <TD nowrap align="center"><HR size="1" noshade></TD>
</TR>
<TR valign="bottom">
        <TD valign="top" align="right"><FONT size="2">4.</FONT></TD>
        <TD nowrap align="left" valign="top"><FONT size="2">
1(1)
</FONT></TD>
        <TD><FONT size="2">&nbsp;</FONT></TD>
        <TD align="left" valign="top"><FONT size="2">Specimen common stock certificate</FONT></TD>
</TR>

<TR valign="bottom">
        <TD valign="top" align="right"><FONT size="2">4.</FONT></TD>
        <TD align="left" valign="top"><FONT size="2">
2(1)
</FONT></TD>
        <TD><FONT size="2">&nbsp;</FONT></TD>
        <TD align="left" valign="top"><FONT size="2">2000 Equity Participation Plan of Gen-Probe Incorporated</FONT></TD>
</TR>

<TR valign="bottom">
        <TD valign="top" align="right"><FONT size="2">5.</FONT></TD>
        <TD align="left" valign="top"><FONT size="2">
1*
</FONT></TD>
        <TD><FONT size="2">&nbsp;</FONT></TD>
        <TD align="left" valign="top"><FONT size="2">Opinion of Latham &#038; Watkins</FONT></TD>
</TR>

<TR valign="bottom">
        <TD valign="top" align="right"><FONT size="2">23.</FONT></TD>
        <TD align="left" valign="top"><FONT size="2">
1*
</FONT></TD>
        <TD><FONT size="2">&nbsp;</FONT></TD>
        <TD align="left" valign="top"><FONT size="2">Consent of Ernst &#038; Young, LLP, independent auditors</FONT></TD>
</TR>

<TR valign="bottom">
        <TD valign="top" align="right"><FONT size="2">23.</FONT></TD>
        <TD align="left" valign="top"><FONT size="2">
2*
</FONT></TD>
        <TD><FONT size="2">&nbsp;</FONT></TD>
        <TD align="left" valign="top"><FONT size="2">Consent of Latham &#038; Watkins (reference is made to Exhibit&nbsp;5.1)</FONT></TD>
</TR>

<TR valign="bottom">
        <TD valign="top" align="right"><FONT size="2">24.</FONT></TD>
        <TD align="left" valign="top"><FONT size="2">
1*
</FONT></TD>
        <TD><FONT size="2">&nbsp;</FONT></TD>
        <TD align="left" valign="top"><FONT size="2">Power of Attorney (included in signature page)</FONT></TD>
</TR>
</TABLE>
</CENTER>
<P>
<HR size="1" width="18%" align="left" noshade>
<TABLE width="100%" border="0" cellpadding="0" cellspacing="0">
<TR valign="top">
      <TD width="1%" align="left" nowrap><FONT size="2">*</FONT></TD>
        <TD width="3%"><FONT size="2">&nbsp;</FONT></TD>
        <TD width="96%"><FONT size="2">Filed herewith.</FONT></TD>
</TR>
<TR><TD><TR><TD><TR><TD><TR><TD>
<TR valign="top">
      <TD width="1%" align="left" nowrap><FONT size="2">(1)</FONT></TD>
        <TD width="3%"><FONT size="2">&nbsp;</FONT></TD>
        <TD width="96%"><FONT size="2">Filed as an exhibit to the Registrant&#146;s Registration Statement on Form
10, as amended (File No.&nbsp;0-49834), and incorporated herein by reference.</FONT></TD>
</TR>
</TABLE>

<P align="center"><FONT size="2">&nbsp;</FONT>


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{"company-data": {"conformed-name": "GEN PROBE INC", "cik": "0000820237", "assigned-sic": "8731", "irs-number": "330044608", "state-of-incorporation": "DE", "fiscal-year-end": "1231"}, "filing-values": {"form-type": "S-8", "act": "33", "file-number": "333-99947", "film-number": "02769049"}, "business-address": {"street1": "10210 GENETIC CENTER DR.", "city": "SAN DIEGO", "state": "CA", "zip": "92121", "phone": "8584108000"}, "mail-address": {"street1": "10210 GENETIC CENTER DR", "city": "SAN DIEGO", "state": "CA", "zip": "92121"}}
Gen-Probe Incorporated
Table of Contents
As filed with the Securities and Exchange Commission on September 20, 2002
Registration No. 333-________
SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM S-8
REGISTRATION STATEMENT
UNDER
THE SECURITIES ACT OF 1933
Gen-Probe Incorporated
(Exact name of registrant as specified in its charter)
Delaware
(State or other jurisdiction
of incorporation or organization)
33-0044608
(I.R.S. Employer
Identification No.)
10210 Genetic Center Drive
San Diego, California 92121
(858) 410-8000
(Address of principal executive offices, including zip code, and telephone number)
2000 Equity Participation Plan of Gen-Probe Incorporated
(Full title of the plan)
Henry L. Nordhoff
Chief Executive Officer
Gen-Probe Incorporated
10210 Genetic Center Drive
San Diego, California 92121
(858) 410-8000
(Name, address, including zip code, and telephone number,
including area code, of agent for service)
Copies to:
Scott N. Wolfe, Esq.
Latham & Watkins
12636 High Bluff Drive, Suite 300
San Diego, California 92130
(858) 523-5400
CALCULATION OF REGISTRATION FEE
Amount
Proposed Maximum
Proposed Maximum
Amount of
Title of Securities
to be
Offering Price
Aggregate
Registration
to be Registered
Registered(1)
Per Share
Offering Price
Fee
Common Stock, $.0001 par value
2,413,973
$(2)
$
63,605,787
$5,852
(1)
Pursuant to Rule 416(a), this Registration Statement shall also cover
any additional shares of the Registrant's Common Stock that become
issuable by reason of any stock dividend, stock split, recapitalization or
other similar transaction effected without receipt of consideration that
increases the number of the Registrant's outstanding shares of common
stock.
(2)
This estimate is made pursuant to Rule 457(h) solely for the purpose of
calculating the registration fee, and is determined according to the
following offering price information: of the 2,413,973 shares of Common
Stock reserved for issuance under the 2000 Equity Participation Plan of
Gen-Probe Incorporated (the "2000 Plan") being registered hereunder, (i)
1,960,170 shares of Common Stock are subject to outstanding options with
an exercise price of $27.31 per share, (ii) 353,571 shares of Common Stock
are subject to outstanding options with an exercise price of $24.58 per
share, (iii) 50,000 shares of Common Stock are subject to outstanding options with an exercise price of $13.50 per share and (iv) 50,232 shares of Common Stock are reserved for issuance
upon exercise of options to be granted in the future. Pursuant to Rule
457(h), for all shares of Common Stock being registered hereunder with an
exercise price which cannot be presently determined (50,232 shares), the
Proposed Maximum Offering Price Per Share is $14.09 per share of
Common Stock, which is based on the average of the high and low prices for
the Common Stock as reported on the Nasdaq National Market on September
18, 2002.
TABLE OF CONTENTS
Part I
Item 1. Plan Information.
Item 2. Registrant Information and Employee Plan Annual Information.
Part II
Item 3. Incorporation of Documents by Reference.
Item 4. Description of Securities.
Item 5. Interests of Named Experts and Counsel.
Item 6. Indemnification of Directors and Officers.
Item 7. Exemption from Registration Claimed.
Item 8. Exhibits.
Item 9. Undertakings.
SIGNATURES
EXHIBIT INDEX
EXHIBIT 5.1
EXHIBIT 23.1
Table of Contents
Part I
Item 1. Plan Information.
Not required to be filed with this Registration Statement.
Item 2. Registrant Information and Employee Plan Annual Information.
Not required to be filed with this Registration Statement.
Part II
Item 3. Incorporation of Documents by Reference.
The Securities and Exchange Commission (the "Commission") allows us to
incorporate by reference the information we file with it, which means that we
can disclose important information to you by referring to those documents. The
information incorporated by reference is an important part of this Registration
Statement, and information that we file later with the Commission will
automatically update and supersede this information. We incorporate by
reference the following documents we have filed, or may file, with the
Commission:
•
Our Registration Statement on Form 10, as amended (the "Form
10") (File No. 0-49834) filed under the Securities Exchange Act of
1934, as amended (the "Exchange Act"), which contains audited
financial statements for our latest fiscal year;
•
Our Quarterly Report on Form 10-Q for the quarter ended June
30, 2002 filed with the Commission on August 27, 2002;
•
Our Current Report on Form 8-K filed with the Commission on September 11, 2002;
•
Our Current Report on Form 8-K filed with the Commission on September 17, 2002;
•
The description of our common stock contained in the Form 10; and
•
All documents filed by us with the Commission under Sections
13(a), 13(c), 14 or 15(d) of the Exchange Act after the date this
Registration Statement is filed with the Commission and prior to the
filing of a post-effective amendment which indicates that all
securities offered have been sold or which deregisters all
securities then remaining unsold shall be deemed to be incorporated
by reference in this Registration Statement and to be a part of it
from the respective dates of filing of those documents.
A statement contained in a document incorporated by reference herein shall
be deemed to be modified or superseded for purposes of this Registration
Statement to the extent that a statement contained herein or in any other
subsequently filed document which is also incorporated herein modifies or
replaces such statement. Any statements so modified or superceded shall not be
deemed, except as so modified or superceded, to constitute a part of this
Registration Statement.
Item 4. Description of Securities
.
Not applicable.
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Item 5. Interests of Named Experts and Counsel.
Not applicable.
Item 6. Indemnification of Directors and Officers.
Section 145 of the Delaware General Corporation Law provides that a
corporation may indemnify any current or former director, officer or employee
or other individual against expenses, judgments, fines and amounts paid in
settlement in connection with civil, criminal, administrative or investigative
actions or proceedings, other than a derivative action by or in the right of
the corporation, if the director, officer, employee or other individual acted
in good faith and in a manner he or she reasonably believed to be in or not
opposed to the best interests of the corporation, and, with respect to any
criminal action or proceeding, if he or she had no reasonable cause to believe
his or her conduct was unlawful. A similar standard is applicable in the case
of derivative actions, except that indemnification only extends to expenses
incurred in connection with the defense or settlement of such actions, and the
statute requires court approval before there can be any indemnification where
the person seeking indemnification has been found liable to the corporation.
The statute provides that it is not exclusive of other indemnification that may
be granted by a corporation's bylaws, disinterested director vote, stockholder
vote, agreement or otherwise.
Our certificate of incorporation provides that each person who was or is
made or is threatened to be made a party to any action or proceeding by reason
of the fact that such person, or a person of whom such person is the legal
representative, is or was a director or officer of us or is or was serving at
our request as a director or officer of another corporation or of a
partnership, joint venture, trust or other enterprise, including service with
respect to employee benefit plans, will be indemnified and held harmless by us
to the fullest extent authorized by the Delaware General Corporation Law, as
the same exists or may hereafter be amended. Such rights are not exclusive of
any other right which any person may have or thereafter acquire under any
statute, provision of the certificate, bylaw, agreement, vote of stockholders
or disinterested directors or otherwise. Our certificate of incorporation also
specifically authorizes us to maintain insurance and to grant similar
indemnification rights to our employees or agents. We have extended similar
indemnification rights to our employees and agents pursuant to our bylaws.
We also intend to enter into indemnification agreements with each of our
directors and executive officers that provide for mandatory indemnification of
an officer or director made party to a "proceeding" by reason of the fact that
he or she is or was an officer or director of ours, if he or she acted in good
faith and in a manner he or she reasonably believed to be in or not opposed to
our best interests. These agreements also obligate us to advance expenses to an
indemnitee provided that he or she agrees to repay advanced expenses in the
event he or she is not entitled to indemnification. Indemnitees are also
entitled to partial indemnification, and indemnification for expenses incurred
as a result of acting at our request as a director, officer or agent of an
employee benefit plan or other partnership, corporation, joint venture, trust
or other enterprise owned or controlled by us.
Insofar as indemnification for liabilities arising under the Securities
Act of 1933, as amended (the "Securities Act"), may be permitted to our
directors, officers and controlling persons pursuant to the above statutory
provisions or otherwise, we have been advised that, in the opinion of the
Commission, indemnification is against public policy as expressed in the
Securities Act and is, therefore, unenforceable.
Item 7. Exemption from Registration Claimed.
Not applicable.
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Item 8. Exhibits.
Exhibit
Number
Description of Exhibit
4.
1(1)
Specimen common stock certificate
4.
2(1)
2000 Equity Participation Plan of Gen-Probe Incorporated
5.
1*
Opinion of Latham & Watkins
23.
1*
Consent of Ernst & Young, LLP, independent auditors
23.
2*
Consent of Latham & Watkins (reference is made to Exhibit 5.1)
24.
1*
Power of Attorney (included in signature page)
*
Filed herewith.
(1)
Filed as an exhibit to the Registrant's Registration Statement on Form
10, as amended (File No. 0-49834), and incorporated herein by reference.
Item 9. Undertakings.
(a)  The undersigned Registrant hereby undertakes:
(1) To file, during any period in which offers or sales are being made, a
post-effective amendment to this Registration Statement;
(i) To include any prospectus required by Section 10(a)(3) of
the Securities Act;
(ii) To reflect in the prospectus any facts or events arising
after the effective date of this Registration Statement (or the
most recent post-effective amendment thereof) which, individually
or in the aggregate, represent a fundamental change in the
information set forth in this Registration Statement.
Notwithstanding the foregoing, any increase or decrease in volume
of securities offered (if the total dollar value of securities
offered would not exceed that which was registered) and any
deviation from the low or high and of the estimated maximum
offering range may be reflected in the form of prospectus filed
with the Commission pursuant to Rule 424(b) if, in the aggregate,
the changes in volume and price represent no more than 20 percent
change in the maximum aggregate offering price set forth in the
"Calculation of Registration Fee" table in the effective
Registration Statement;
(iii) To include any material information with respect to the
plan of distribution not previously disclosed in this Registration
Statement or any material change to such information in this
Registration Statement;
provided, however
, that the undertakings set forth in paragraphs (a)(1)(i) and
(a)(1)(ii) above do not apply if the Registration Statement is on Form S-3,
Form S-8 or Form F-3, and the information required to be included in a
post-effective amendment by those paragraphs is contained in periodic reports
filed with or furnished to the Commission by the Registrant pursuant to Section
13 or 15(d) of the Exchange Act that are incorporated by reference in this
Registration Statement.
(2) That, for the purpose of determining any liability under the
Securities Act, each such post-effective amendment shall be deemed to be a new
registration statement relating to the securities offered therein, and the
offering of such securities at that time shall be deemed to be the initial
bona
fide
offering thereof.
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(3) To remove from registration by means of a post-effective amendment any
of the securities being registered which remain unsold at the termination of
the offering.
(b)  The undersigned Registrant hereby undertakes that, for purposes of
determining any liability under the Securities Act, each filing of the
Registrant's annual report pursuant to Section 13(a) or
15(d) of the Exchange Act (and, where applicable, each filing of an employee
benefit plan's annual report pursuant to Section 15(d) of the Exchange Act)
that is incorporated by reference in this Registration Statement shall be
deemed to be a new registration statement relating to the securities offered
therein, and the offering of such securities at that time shall be deemed to be
the initial bona fide offering thereof.
(c)  Insofar as indemnification for liabilities arising under the
Securities Act may be permitted to directors, officers and controlling persons
of the Registrant pursuant to the foregoing provisions, or otherwise, the
Registrant has been advised that in the opinion of the Commission such
indemnification is against public policy as expressed in the Securities Act and
is, therefore, unenforceable. In the event that a claim for indemnification
against such liabilities (other than the payment by the Registrant of expenses
incurred or paid by a director, officer or controlling person of the Registrant
in the successful defense of any action, suit or proceeding) is asserted by
such director, officer or controlling person in connection with the securities
being registered, the Registrant will, unless in the opinion of its counsel the
matter has been settled by controlling precedent, submit to a court of
appropriate jurisdiction the question whether such indemnification by it is
against public policy as expressed in the Securities Act and will be governed
by the final adjudication of such issue.
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SIGNATURES
Pursuant to the requirements of the Securities Act, the Registrant
certifies that it has reasonable grounds to believe that it meets all of the
requirements for filing on Form S-8, and has duly caused this Registration
Statement to be signed on its behalf by the undersigned, thereunto duly
authorized, in the City of San Diego, County of San Diego, State of California,
on this 19th day of September, 2002.
By:
/s/ Henry L. Nordhoff
Henry L. Nordhoff
President and Chief Executive
Officer
POWER OF ATTORNEY
KNOW ALL PERSONS BY THESE PRESENTS, that each person whose signature
appears below constitutes and appoints Henry L. Nordhoff and Herm Rosenman and
each of them, as his true and lawful attorneys-in-fact and agents, with full
power of substitution and resubstitution, for him and in his name, place, and
stead, in any and all capacities, to sign any and all amendments (including
post-effective amendments, exhibits thereto and other documents in connection
therewith) to this Registration Statement and any subsequent registration
statement filed by the Registrant pursuant to Rule 462(b) of the Securities
Act, which relates to this Registration Statement, and to file the same, with
all exhibits thereto, and other documents in connection therewith, with the
Commission, granting unto said attorneys-in-fact and agents, and each of them,
full power and authority to do and perform each and every act and thing
requisite and necessary to be done in connection therewith, as fully to all
intents and purposes as he might or could do in person, hereby ratifying and
confirming all that said attorney-in-fact and agents, or any of them, or their
or his substitute or substitutes, may lawfully do or cause to be done by virtue
hereof.
Pursuant to the requirements of the Securities Act, this Registration
Statement has been signed by the following persons in the capacities and on the
date indicated.
Signature
Title
Date
/s/ Henry L. Nordhoff
Henry L. Nordhoff
President, Chief Executive
Officer and Director
(Principal Executive Officer)
September 19, 2002
/s/ Herm Rosenman
Herm Rosenman
Vice President – Finance
and Chief Financial Officer
(Principal Financial Officer
and Principal Accounting
Officer)
September 19, 2002
/s/ Raymond V. Dittamore
Raymond V. Dittamore
Director
September 19, 2002
/s/ Kiyoshi Kurokawa, M.D., MACP
Kiyoshi Kurokawa, M.D., MACP
Director
September 19, 2002
/s/ Gerald D. Laubach, Ph.D.
Gerald D. Laubach, Ph.D.
Director
September 20, 2002
/s/ Brian A. McNamee, M.B.
Brian A. McNamee, M.B.
Director
September 16, 2002
Table of Contents
Signature
Title
Date
/s/ Abraham D. Sofaer
Abraham D. Sofaer
Director
September 19, 2002
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EXHIBIT INDEX
Exhibit
Number
Description of Exhibit
4.
1(1)
Specimen common stock certificate
4.
2(1)
2000 Equity Participation Plan of Gen-Probe Incorporated
5.
1*
Opinion of Latham & Watkins
23.
1*
Consent of Ernst & Young, LLP, independent auditors
23.
2*
Consent of Latham & Watkins (reference is made to Exhibit 5.1)
24.
1*
Power of Attorney (included in signature page)
*
Filed herewith.
(1)
Filed as an exhibit to the Registrant's Registration Statement on Form
10, as amended (File No. 0-49834), and incorporated herein by reference.