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<H5 align="left" style="page-break-before:always"><A HREF="#toc">Table of Contents</A></H5><P>

<P align="left"><FONT size="2">As filed with the Securities And
Exchange Commission on September&nbsp;25, 2002</FONT>

<P align="right"><FONT size="2">REGISTRATION NO. 333-_______</FONT>

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<P align="center"><FONT size="2">UNITED STATES SECURITIES AND EXCHANGE COMMISSION<BR>
Washington, D.C. 20549</FONT>

<P align="center"><FONT size="2">FORM S-8</FONT>

<P align="center"><FONT size="2">REGISTRATION STATEMENT<BR>
UNDER<BR>
THE SECURITIES ACT OF 1933</FONT>

<P align="center"><FONT size="2">GENETRONICS BIOMEDICAL CORPORATION<BR>
(Exact name of registrant as specified in its charter)</FONT>

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        <TD align="center" valign="top"><FONT size="2">DELAWARE</FONT></TD>
        <TD><FONT size="2">&nbsp;</FONT></TD>
        <TD align="center" valign="top"><FONT size="2">
33-0969592</FONT></TD>
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        <TD><FONT size="2">&nbsp;</FONT></TD>
        <TD align="center" valign="top"><FONT size="2">
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        <TD align="center" valign="top"><FONT size="2">(State or other jurisdiction<BR>
of incorporation or organization)</FONT></TD>
        <TD><FONT size="2">&nbsp;</FONT></TD>
        <TD align="center" valign="top"><FONT size="2">
(I.R.S. Employer Identification Number)</FONT></TD>
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<P align="center"><FONT size="2">11199 SORRENTO VALLEY ROAD<BR>
SAN DIEGO, CALIFORNIA 92121-1334<BR>
(858)&nbsp;597-6006</FONT>

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<DIV align="center"><FONT size="2"><FONT size="2">(Address, Zip Code and Telephone<BR>
Number of Principal Executive Offices)</FONT></FONT></DIV>

<P align="center"><FONT size="2">2000 STOCK OPTION PLAN</FONT>

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<DIV align="center"><FONT size="2"><FONT size="2">(Full title of the plan)</FONT></FONT></DIV>

<P align="center"><FONT size="2">Avtar Dhillon<BR>
President, Chief Executive Officer<BR>
11199 Sorrento Valley Road<BR>
San Diego, California 92121-1334</FONT>

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<DIV align="center"><FONT size="2"><FONT size="2">(Name, address and telephone number of agent for service)</FONT></FONT></DIV>
<P align="center"><FONT size="2">COPY TO:</FONT>

<P align="center"><FONT size="2">Douglas J. Rein, Esq.<BR>
Gray Cary Ware &#038; Freidenrich LLP<BR>
4365 Executive Drive, Suite&nbsp;1100<BR>
San Diego, Ca 92121-2133<BR>
Telephone: (858)&nbsp;677-1400<BR>
Facsimile: (858)&nbsp;677-1477</FONT>

<P><FONT size="2">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;This registration statement shall become effective in accordance with Rule
462 promulgated under the Securities Act of 1933, as amended.
</FONT>

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<DIV align="center"><FONT size="2"><B>CALCULATION OF REGISTRATION FEE</B></FONT></DIV>

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        <TD><FONT size="1">&nbsp;</FONT></TD>
        <TD><FONT size="1">&nbsp;</FONT></TD>
        <TD nowrap align="center" colspan="3"><FONT size="1"><B>Proposed maximum</B></FONT></TD>
        <TD><FONT size="1">&nbsp;</FONT></TD>
        <TD nowrap align="center" colspan="3"><FONT size="1"><B>Proposed maximum</B></FONT></TD>
        <TD><FONT size="1">&nbsp;</FONT></TD>
        <TD nowrap align="center" colspan="3"><FONT size="1"><B>Amount of</B></FONT></TD>
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        <TD nowrap align="center"><FONT size="1"><B>Title of securities</B></FONT></TD>
        <TD><FONT size="1">&nbsp;</FONT></TD>
        <TD nowrap align="center" colspan="3"><FONT size="1"><B>Amount to be</B></FONT></TD>
        <TD><FONT size="1">&nbsp;</FONT></TD>
        <TD nowrap align="center" colspan="3"><FONT size="1"><B>offering price per</B></FONT></TD>
        <TD><FONT size="1">&nbsp;</FONT></TD>
        <TD nowrap align="center" colspan="3"><FONT size="1"><B>aggregate offering</B></FONT></TD>
        <TD><FONT size="1">&nbsp;</FONT></TD>
        <TD nowrap align="center" colspan="3"><FONT size="1"><B>Registration</B></FONT></TD>
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        <TD nowrap align="center"><FONT size="1"><B>to be registered(1)</B></FONT></TD>
        <TD><FONT size="1">&nbsp;</FONT></TD>
        <TD nowrap align="center" colspan="3"><FONT size="1"><B>registered(2)</B></FONT></TD>
        <TD><FONT size="1">&nbsp;</FONT></TD>
        <TD nowrap align="center" colspan="3"><FONT size="1"><B>share(3)</B></FONT></TD>
        <TD><FONT size="1">&nbsp;</FONT></TD>
        <TD nowrap align="center" colspan="3"><FONT size="1"><B>price(3)</B></FONT></TD>
        <TD><FONT size="1">&nbsp;</FONT></TD>
        <TD nowrap align="center" colspan="3"><FONT size="1"><B>Fee</B></FONT></TD>
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        <TD><DIV style="margin-left:10px; text-indent:-10px"><FONT size="2">Common Stock, $0.001 par value</FONT></DIV></TD>
        <TD><FONT size="2">&nbsp;</FONT></TD>
        <TD><FONT size="2">&nbsp;</FONT></TD>
        <TD align="right"><FONT size="2">2,600,000</FONT></TD>
        <TD><FONT size="2">&nbsp;</FONT></TD>
        <TD><FONT size="2">&nbsp;</FONT></TD>
        <TD align="right"><FONT size="2">$</FONT></TD>
        <TD align="right"><FONT size="2">0.15</FONT></TD>
        <TD><FONT size="2">&nbsp;</FONT></TD>
        <TD><FONT size="2">&nbsp;</FONT></TD>
        <TD align="right"><FONT size="2">$</FONT></TD>
        <TD align="right"><FONT size="2">390,000</FONT></TD>
        <TD><FONT size="2">&nbsp;</FONT></TD>
        <TD><FONT size="2">&nbsp;</FONT></TD>
        <TD align="right"><FONT size="2">$</FONT></TD>
        <TD align="right"><FONT size="2">36</FONT></TD>
        <TD><FONT size="2">&nbsp;</FONT></TD>
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      <TD width="1%" align="left" nowrap><FONT size="2">(1)</FONT></TD>
        <TD width="3%"><FONT size="2">&nbsp;</FONT></TD>
        <TD width="96%"><FONT size="2">The securities to be registered include options to acquire Common Stock.</FONT></TD>
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<TR><TD><TR><TD><TR><TD><TR><TD>
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      <TD width="1%" align="left" nowrap><FONT size="2">(2)</FONT></TD>
        <TD width="3%"><FONT size="2">&nbsp;</FONT></TD>
        <TD width="96%"><FONT size="2">Pursuant to Rule&nbsp;416(a) under the Securities Act of 1933, as amended, this
registration statement also covers any additional securities that may be
offered or issued in connection with any stock split, stock dividend or similar
transaction.</FONT></TD>
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<TR><TD><TR><TD><TR><TD><TR><TD>
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      <TD width="1%" align="left" nowrap><FONT size="2">(3)</FONT></TD>
        <TD width="3%"><FONT size="2">&nbsp;</FONT></TD>
        <TD width="96%"><FONT size="2">Estimated solely for the purpose of calculating the amount of the
registration fee pursuant to Rule&nbsp;457( c ) of the Securities Act of 1993, as
amended, based on the average of the high and low prices of the Company&#146;s
Common Stock on September&nbsp;23, 2002.</FONT></TD>
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<P align="center"><FONT size="2">&nbsp;
</FONT>

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<A name="toc"><DIV align="CENTER" style="page-break-before:always"><U><B>TABLE OF CONTENTS</B></U></DIV></A>

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<TR><TD colspan="9"><A HREF="#000">PART II INFORMATION REQUIRED IN THE REGISTRATION STATEMENT</A></TD></TR>
<TR><TD></TD><TD colspan="8"><A HREF="#001">Item&nbsp;3. Incorporation of Documents by Reference</A></TD></TR>
<TR><TD></TD><TD colspan="8"><A HREF="#002">Item&nbsp;4. Description of Securities</A></TD></TR>
<TR><TD></TD><TD colspan="8"><A HREF="#003">Item&nbsp;5. Interests of Named Experts and Counsel</A></TD></TR>
<TR><TD></TD><TD colspan="8"><A HREF="#004">Item&nbsp;6. Indemnification of Directors and Officers</A></TD></TR>
<TR><TD></TD><TD colspan="8"><A HREF="#005">Item&nbsp;7. Exemption From Registration Claimed</A></TD></TR>
<TR><TD></TD><TD colspan="8"><A HREF="#006">Item&nbsp;8. Exhibits</A></TD></TR>
<TR><TD></TD><TD colspan="8"><A HREF="#007">Item&nbsp;9. Undertakings</A></TD></TR>
<TR><TD colspan="9"><A HREF="#008">SIGNATURE</A></TD></TR>
<TR><TD colspan="9"><A HREF="#009">EXHIBIT INDEX</A></TD></TR>
<TR><TD colspan="9"><A HREF="a84399orexv5w1.txt">EXHIBIT 5.1</A></TD></TR>
<TR><TD colspan="9"><A HREF="a84399orexv23w1.txt">EXHIBIT 23.1</A></TD></TR>
<TR><TD colspan="9"><A HREF="a84399orexv23w2.txt">EXHIBIT 23.2</A></TD></TR>
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<!-- link1 "PART II INFORMATION REQUIRED IN THE REGISTRATION STATEMENT" -->
<DIV align="left"><A NAME="000"></A></DIV>
<P align="center"><FONT size="2">PART II</FONT>

<P align="center"><FONT size="2">INFORMATION REQUIRED IN THE REGISTRATION STATEMENT</FONT>

<!-- link2 "Item&nbsp;3. Incorporation of Documents by Reference" -->
<DIV align="left"><A NAME="001"></A></DIV>
<P align="left"><FONT size="2">Item&nbsp;3. Incorporation of Documents by Reference</FONT>

<P><FONT size="2">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;The following documents filed with the Securities and Exchange Commission
(the &#147;Commission&#148;) by Genetronics Biomedical Corporation (the &#147;Company&#148;) are
incorporated by reference in this Registration Statement:
</FONT>
<P><FONT size="2">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;a.&nbsp;our latest annual report on Form&nbsp;10-K for the transition period ended
December&nbsp;31, 2001;
</FONT>
<P><FONT size="2">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;b.&nbsp;our quarterly report on Form&nbsp;10-Q for the quarter ended March&nbsp;31, 2002;
</FONT>
<P><FONT size="2">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;c.&nbsp;our quarterly report on Form&nbsp;10-Q for the quarter ended June&nbsp;30, 2002;
</FONT>
<P><FONT size="2">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;d.&nbsp;our Form&nbsp;8-K filed February&nbsp;22, 2002 (as amended by Amendment No.&nbsp;1 to
Form&nbsp;8-K filed on March&nbsp;12, 2002 and Amendment No.&nbsp;2 to Form&nbsp;8-K filed on March
25, 2002);
</FONT>
<P><FONT size="2">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;e.&nbsp;our Form&nbsp;8-K filed March&nbsp;22, 2002 (as amended by Amendment No.&nbsp;1 to
Form&nbsp;8-K filed March&nbsp;28, 2002);
</FONT>
<P><FONT size="2">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;f.&nbsp;our Form&nbsp;8-K filed May&nbsp;24, 2002;
</FONT>
<P><FONT size="2">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;g.&nbsp;our Form&nbsp;8-K filed June&nbsp;14, 2002;
</FONT>
<P><FONT size="2">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;h.&nbsp;our Form&nbsp;8-K filed August&nbsp;19, 2002; and
</FONT>
<P><FONT size="2">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;i.&nbsp;the description of the Company&#146;s common stock contained in our Form&nbsp;S-4
filed March&nbsp;14, 2001.
</FONT>
<P><FONT size="2">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;All documents filed by the Company with the Commission pursuant to
Sections&nbsp;13(a), 13(c), 14 or 15(d) of the Exchange Act after the date of this
Registration Statement and prior to the filing of a post-effective amendment
which indicates that all shares of Common Stock offered pursuant to this
Registration Statement have been sold or that deregisters all shares of Common
Stock then remaining unsold, shall be deemed to be incorporated by reference in
this Registration Statement and to be a part hereof from the date of filing of
such documents.
</FONT>
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<DIV align="left"><A NAME="002"></A></DIV>
<P align="left"><FONT size="2">Item&nbsp;4. Description of Securities</FONT>

<P><FONT size="2">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;The class of securities to be offered is registered under Section&nbsp;12 of
the Exchange Act.
</FONT>
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<DIV align="left"><A NAME="003"></A></DIV>
<P align="left"><FONT size="2">Item&nbsp;5. Interests of Named Experts and Counsel</FONT>

<P><FONT size="2">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Inapplicable.
</FONT>
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<DIV align="left"><A NAME="004"></A></DIV>
<P align="left"><FONT size="2">Item&nbsp;6. Indemnification of Directors and Officers</FONT>

<P><FONT size="2">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Section&nbsp;102(b) of the Delaware General Corporation Law authorizes a
corporation to provide in its Certificate of Incorporation that a director of
the corporation shall not be personally liable to the corporation or its
stockholders for monetary damages for breach or alleged breach of the
director&#146;s &#147;duty of care.&#148; While this statute does not change the directors&#146;
duty of care, it enables corporations to limit available relief to equitable
remedies such as injunction or rescission. The statute has no effect on a
director&#146;s duty of loyalty or liability for acts or omissions not in good faith
or involving intentional misconduct or knowing violations of law, illegal
payment of dividends or stock redemptions or repurchases, or for any
transaction from which the director derives an improper personal benefit.
</FONT>
<P><FONT size="2">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;As permitted by the statute, we have adopted provisions in our Certificate
of Incorporation which eliminate to the fullest extent permissible under
Delaware law the personal liability of our directors to us and to our
stockholders for monetary damages for breach or alleged breach of the duty of
care.
</FONT>
<P align="center"><FONT size="2">&nbsp;
</FONT>

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<P><FONT size="2">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Section&nbsp;145 of the Delaware General Corporation Law provides generally
that a corporation shall have the power, and in some cases is required, to
indemnify an agent, including an officer or director, who was or is a party or
is threatened to be made a party to any threatened, pending or completed
action, suit or proceeding, whether civil, criminal, administrative or
investigative (other than an action by or in the right of the corporation) by
reason of the fact that he or she is or was a director, officer, employee or
agent of the corporation, against certain expenses, judgments, fines,
settlements, and other amounts under certain circumstances.
</FONT>
<P><FONT size="2">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Our Bylaws provide for indemnification (to the full extent permitted by
the Delaware General Corporation Law) of directors, officers, employees and
other agents of the Company against all expenses, liability and loss (including
attorney&#146;s fees, judgment, fines, ERISA excise taxes or penalties, amounts paid
or to be paid in settlement and amounts expended in seeking indemnification
granted to such person under applicable law, the Bylaws or any agreement with
us) reasonably incurred or suffered by such person in connection therewith,
subject to certain provisions. Our Bylaws also empower us to maintain directors
and officers liability insurance coverage and to enter into indemnification
agreements with our directors, officers, employees or agents.
</FONT>
<P><FONT size="2">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;These indemnification provisions may be sufficiently broad to permit
indemnification of the Company&#146;s officers and directors for liabilities
(including reimbursement of expenses incurred) arising under the Securities
Act.
</FONT>
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<DIV align="left"><A NAME="005"></A></DIV>
<P align="left"><FONT size="2">Item&nbsp;7. Exemption From Registration Claimed</FONT>

<P><FONT size="2">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Inapplicable.
</FONT>
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<DIV align="left"><A NAME="006"></A></DIV>
<P align="left"><FONT size="2">Item&nbsp;8. Exhibits</FONT>

<P><FONT size="2">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;See Exhibit&nbsp;Index.
</FONT>
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<DIV align="left"><A NAME="007"></A></DIV>
<P align="left"><FONT size="2">Item&nbsp;9. Undertakings</FONT>

<P><FONT size="2">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(a)&nbsp; The undersigned registrant hereby undertakes:
</FONT>
<P><FONT size="2">(1)&nbsp; To file, during any period in which offers or sales are being made, a
post-effective amendment to this registration statement:
</FONT>
<P><FONT size="2">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(i)&nbsp; To include any prospectus required by Section&nbsp;10(a)(3) of the
Securities Act of 1933;
</FONT>
<P><FONT size="2">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(ii)&nbsp; To reflect in the prospectus any facts or events arising after the
effective date of the registration statement (or the most recent post-effective
amendment thereof) which, individually or in the aggregate, represent a
fundamental change in the information set forth in the registration statement.
Notwithstanding the foregoing, any increase or decrease in volume of securities
offered (if the total dollar value of securities offered would not exceed that
which was registered) and any deviation from the low or high end of the
estimated maximum offering range may be reflected in the form of prospectus
filed with the Commission pursuant to Rule&nbsp;424(b) if, in the aggregate, the
changes in volume and price represent no more than a 20% change in the maximum
aggregate offering price set forth in the &#147;Calculation of Registration Fee&#148;
table in the effective registration statement;
</FONT>
<P><FONT size="2">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(iii)&nbsp; To include any material information with respect to the plan of
distribution not previously disclosed in the registration statement or any
material change to such information in the registration statement; provided,
however, that paragraphs (a)(1)(i) and (a)(l)(ii) do not apply if the
registration statement is on Form&nbsp;S-3 or Form&nbsp;S-8, and the information required
to be included in a post-effective amendment by those paragraphs is contained
in periodic reports filed by the registrant pursuant to Section&nbsp;13 or Section
15(d) of the Exchange Act that are incorporated by reference in the
registration statement.
</FONT>
<P><FONT size="2">(2)&nbsp; That, for the purpose of determining any liability under the Securities Act
of 1933, each such post-effective amendment shall be deemed to be a new
registration statement relating to the securities offered therein, and the
offering of such securities at that time shall be deemed to be the initial bona
fide offering thereof.
</FONT>
<P align="center"><FONT size="2">&nbsp;
</FONT>

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<P><FONT size="2">(3)&nbsp; To remove from registration by means of a post-effective amendment any of
the securities being registered which remain unsold at the termination of the
offering.
</FONT>
<P><FONT size="2">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(b)&nbsp; The undersigned registrant hereby undertakes that, for purposes of
determining any liability under the Securities Act of 1933, each filing of the
registrant&#146;s annual report pursuant to Section&nbsp;13(a) or Section&nbsp;15(d) of the
Exchange Act (and, where applicable, each filing of an employee benefit plan&#146;s
annual report pursuant to Section&nbsp;15(d) of the Exchange Act) that is
incorporated by reference in the registration statement shall be deemed to be a
new registration statement relating to the securities offered therein, and the
offering of such securities at that time shall be deemed to be the initial bona
fide offering thereof.
</FONT>
<P><FONT size="2">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(c)&nbsp; Insofar as indemnification for liabilities arising under the
Securities Act of 1933 may be permitted to directors, officers and controlling
persons of the registrant pursuant to the foregoing provisions, or otherwise,
the registrant has been advised that in the opinion of the Securities and
Exchange Commission such indemnification is against public policy as expressed
in the Act and is, therefore, unenforceable. In the event that a claim for
indemnification against such liabilities (other than the payment by the
registrant of expenses incurred or paid by a director, officer or controlling
person of the registrant in the successful defense of any action, suit or
proceeding) is asserted by such director, officer or controlling person in
connection with the securities being registered, the registrant will, unless in
the opinion of its counsel the matter has been settled by controlling
precedent, submit to a court of appropriate jurisdiction the question whether
such indemnification by it is against public policy as expressed in the Act and
will be governed by the final adjudication of such issue.
</FONT>
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<DIV align="left"><A NAME="008"></A></DIV>
<P align="center"><FONT size="2">SIGNATURE</FONT>

<P><FONT size="2">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Pursuant to the requirements of the Securities Act of 1933, as amended,
the registrant certifies that it has reasonable grounds to believe that it
meets all of the requirements for filing on Form&nbsp;S-8 and has duly caused this
registration statement to be signed on its behalf by the undersigned, thereunto
duly authorized, in the City of San Diego, State of California, on
September&nbsp;25, 2002.
</FONT>

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        <TD><FONT size="2">&nbsp;</FONT></TD>
        <TD align="left" valign="top" colspan="3"><FONT size="2">Genetronics Biomedical Corporation</FONT></TD>
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<TR><TD>&nbsp;</TD></TR>

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        <TD valign="top"><FONT size="2">&nbsp;</FONT></TD>
        <TD><FONT size="2">&nbsp;</FONT></TD>
        <TD align="left" valign="top"><FONT size="2">By:</FONT></TD>
        <TD><FONT size="2">&nbsp;</FONT></TD>
        <TD align="left" valign="top"><FONT size="2">/s/ Avtar Dhillon</FONT></TD>
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        <TD valign="top"><FONT size="2">&nbsp;</FONT></TD>
        <TD><FONT size="2">&nbsp;</FONT></TD>
        <TD align="left" valign="top"><FONT size="2">&nbsp;</FONT></TD>
        <TD><FONT size="2">&nbsp;</FONT></TD>
        <TD align="left" valign="top"><FONT size="2">Avtar Dhillon<br>
President and Chief Executive Officer</FONT></TD>
</TR>
</TABLE>
</CENTER>
<P align="center"><FONT size="2">&nbsp;
</FONT>

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<P><HR noshade><P>
<H5 align="left" style="page-break-before:always"><A HREF="#toc">Table of Contents</A></H5><P>
<P align="center"><FONT size="2">POWER OF ATTORNEY</FONT>

<P><FONT size="2">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;The officers and directors of Genetronics Biomedical Corporation whose
signatures appear below, hereby constitute and appoint Avtar Dhillon and Peter
Kies, and each of them, their true and lawful attorneys and agents, with full
power of substitution, each with power to act alone, to sign and execute on
behalf of the undersigned any amendment or amendments to this registration
statement on Form&nbsp;S-8, and each of the undersigned does hereby ratify and
confirm all that each of said attorney and agent, or their, her or his
substitutes, shall do or cause to be done by virtue hereof.
</FONT>
<P><FONT size="2">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Pursuant to the requirements of the Securities Act of 1933, as amended,
this registration statement has been signed by the following persons in the
capacities indicated on September&nbsp;25, 2002.
</FONT>
<CENTER>
<TABLE cellspacing="0" border="0" cellpadding="0" width="100%">
<TR valign="bottom">
        <TD width="45%">&nbsp;</TD>
        <TD width="5%">&nbsp;</TD>
        <TD width="50%">&nbsp;</TD>
</TR>
<TR valign="bottom">
        <TD nowrap align="center"><FONT size="1"><B>Signature</B></FONT></TD>
        <TD><FONT size="1">&nbsp;</FONT></TD>
        <TD nowrap align="center"><FONT size="1"><B>Title</B></FONT></TD>
</TR>
<TR valign="bottom">
        <TD nowrap align="center"><HR size="1" noshade></TD>
        <TD><FONT size="1">&nbsp;</FONT></TD>
        <TD nowrap align="center"><HR size="1" noshade></TD>
</TR>
<TR>
        <TD valign="top"><FONT size="2">/s/ Avtar Dhillon
<HR size="1" noshade>
Avtar Dhillon</FONT></TD>
        <TD><FONT size="2">&nbsp;</FONT></TD>
        <TD align="left" valign="top"><FONT size="2">
President, Chief Executive Officer (Principal Executive
Officer) and Director</FONT></TD>
</TR>
<TR><TD>&nbsp;</TD></TR>

<TR>
        <TD valign="top"><FONT size="2">/s/ Peter D. Kies
<HR size="1" noshade>
Peter D. Kies</FONT></TD>
        <TD><FONT size="2">&nbsp;</FONT></TD>
        <TD align="left" valign="top"><FONT size="2">
Chief Financial Officer (Principal Financial and Accounting
Officer)</FONT></TD>
</TR>
<TR><TD>&nbsp;</TD></TR>

<TR>
        <TD valign="top"><FONT size="2">/s/ James L. Heppell
<HR size="1" noshade>
James L. Heppell</FONT></TD>
        <TD><FONT size="2">&nbsp;</FONT></TD>
        <TD align="left" valign="top"><FONT size="2">
Director</FONT></TD>
</TR>

<TR><TD>&nbsp;</TD></TR>

<TR>
        <TD valign="top"><FONT size="2">/s/ Felix Theeuwes
<HR size="1" noshade>
Felix Theeuwes</FONT></TD>
        <TD><FONT size="2">&nbsp;</FONT></TD>
        <TD align="left" valign="top"><FONT size="2">
Director</FONT></TD>
</TR>

<TR><TD>&nbsp;</TD></TR>

<TR>
        <TD valign="top"><FONT size="2">/s/ Tazdin Esmail
<HR size="1" noshade>
Tazdin Esmail</FONT></TD>
        <TD><FONT size="2">&nbsp;</FONT></TD>
        <TD align="left" valign="top"><FONT size="2">
Director</FONT></TD>
</TR>
</TABLE>
</CENTER>
<P align="center"><FONT size="2">&nbsp;
</FONT>

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<H5 align="left" style="page-break-before:always"><A HREF="#toc">Table of Contents</A></H5><P>
<!-- link1 "EXHIBIT INDEX" -->
<DIV align="left"><A NAME="009"></A></DIV>
<P align="center"><FONT size="2">EXHIBIT INDEX</FONT>

<CENTER>
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<TR valign="bottom">
        <TD width="8%">&nbsp;</TD>
        <TD width="5%">&nbsp;</TD>
        <TD width="87%">&nbsp;</TD>
</TR>
<TR valign="bottom">
        <TD nowrap align="center"><FONT size="1"><B>Ex.#</B></FONT></TD>
        <TD><FONT size="1">&nbsp;</FONT></TD>
        <TD nowrap align="center"><FONT size="1"><B>Description</B></FONT></TD>
</TR>
<TR valign="bottom">
        <TD nowrap align="center"><HR size="1" noshade></TD>
        <TD><FONT size="1">&nbsp;</FONT></TD>
        <TD nowrap align="center"><HR size="1" noshade></TD>
</TR>
<TR valign="bottom">
        <TD valign="top"><FONT size="2">4.1*</FONT></TD>
        <TD><FONT size="2">&nbsp;</FONT></TD>
        <TD align="left" valign="top"><FONT size="2">
Certificate of Incorporation</FONT></TD>
</TR>

<TR valign="bottom">
        <TD valign="top"><FONT size="2">4.2**</FONT></TD>
        <TD><FONT size="2">&nbsp;</FONT></TD>
        <TD align="left" valign="top"><FONT size="2">
Bylaws, as amended</FONT></TD>
</TR>

<TR valign="bottom">
        <TD valign="top"><FONT size="2">4.3***</FONT></TD>
        <TD><FONT size="2">&nbsp;</FONT></TD>
        <TD align="left" valign="top"><FONT size="2">
Shareholder Rights Agreement, dated June&nbsp;30, 1997 by and between the Company
and Montreal Trust Company of Canada, as amended on August&nbsp;27, 1997</FONT></TD>
</TR>

<TR valign="bottom">
        <TD valign="top"><FONT size="2">5.1</FONT></TD>
        <TD><FONT size="2">&nbsp;</FONT></TD>
        <TD align="left" valign="top"><FONT size="2">
Opinion and Consent of Gray Cary Ware &#038; Freidenrich LLP</FONT></TD>
</TR>

<TR valign="bottom">
        <TD valign="top"><FONT size="2">23.1</FONT></TD>
        <TD><FONT size="2">&nbsp;</FONT></TD>
        <TD align="left" valign="top"><FONT size="2">
Consent of Ernst &#038; Young LLP (San Diego, United States), Independent Auditors</FONT></TD>
</TR>

<TR valign="bottom">
        <TD valign="top"><FONT size="2">23.2</FONT></TD>
        <TD><FONT size="2">&nbsp;</FONT></TD>
        <TD align="left" valign="top"><FONT size="2">
Consent of Ernst &#038; Young LLP (Vancouver, Canada), Independent Auditors</FONT></TD>
</TR>

<TR valign="bottom">
        <TD valign="top"><FONT size="2">24.1</FONT></TD>
        <TD><FONT size="2">&nbsp;</FONT></TD>
        <TD align="left" valign="top"><FONT size="2">
Power of Attorney (See Signature Page)</FONT></TD>
</TR>
</TABLE>
</CENTER>
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<TR valign="top">
      <TD width="1%" align="left" nowrap><FONT size="2">*</FONT></TD>
        <TD width="3%"><FONT size="2">&nbsp;</FONT></TD>
        <TD width="96%"><FONT size="2">Incorporated by reference from the Form&nbsp;S-4 (333-56978) filed on April&nbsp;5, 2001.</FONT></TD>
</TR>
<TR><TD><TR><TD><TR><TD><TR><TD>
<TR valign="top">
      <TD width="1%" align="left" nowrap><FONT size="2">**</FONT></TD>
        <TD width="3%"><FONT size="2">&nbsp;</FONT></TD>
        <TD width="96%"><FONT size="2">Incorporated by reference from the Form&nbsp;10-Q for the period ended September&nbsp;30, 2001.</FONT></TD>
</TR>
<TR><TD><TR><TD><TR><TD><TR><TD>
<TR valign="top">
      <TD width="1%" align="left" nowrap><FONT size="2">***</FONT></TD>
        <TD width="3%"><FONT size="2">&nbsp;</FONT></TD>
        <TD width="96%"><FONT size="2">Filed as an exhibit to Company&#146;s Form&nbsp;S-1 (333-76738) and incorporated by reference herein.</FONT></TD>
</TR>
</TABLE>

<P align="center"><FONT size="2">&nbsp;</FONT>


</BODY>
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Genetronics Biomedical Corporation
Table of Contents
As filed with the Securities And
Exchange Commission on September 25, 2002
REGISTRATION NO. 333-_______
UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM S-8
REGISTRATION STATEMENT
UNDER
THE SECURITIES ACT OF 1933
GENETRONICS BIOMEDICAL CORPORATION
(Exact name of registrant as specified in its charter)
DELAWARE
33-0969592
(State or other jurisdiction
of incorporation or organization)
(I.R.S. Employer Identification Number)
11199 SORRENTO VALLEY ROAD
SAN DIEGO, CALIFORNIA 92121-1334
(858) 597-6006
(Address, Zip Code and Telephone
Number of Principal Executive Offices)
2000 STOCK OPTION PLAN
(Full title of the plan)
Avtar Dhillon
President, Chief Executive Officer
11199 Sorrento Valley Road
San Diego, California 92121-1334
(Name, address and telephone number of agent for service)
COPY TO:
Douglas J. Rein, Esq.
Gray Cary Ware & Freidenrich LLP
4365 Executive Drive, Suite 1100
San Diego, Ca 92121-2133
Telephone: (858) 677-1400
Facsimile: (858) 677-1477
This registration statement shall become effective in accordance with Rule
462 promulgated under the Securities Act of 1933, as amended.
CALCULATION OF REGISTRATION FEE
Proposed maximum
Proposed maximum
Amount of
Title of securities
Amount to be
offering price per
aggregate offering
Registration
to be registered(1)
registered(2)
share(3)
price(3)
Fee
Common Stock, $0.001 par value
2,600,000
$
0.15
$
390,000
$
36
(1)
The securities to be registered include options to acquire Common Stock.
(2)
Pursuant to Rule 416(a) under the Securities Act of 1933, as amended, this
registration statement also covers any additional securities that may be
offered or issued in connection with any stock split, stock dividend or similar
transaction.
(3)
Estimated solely for the purpose of calculating the amount of the
registration fee pursuant to Rule 457( c ) of the Securities Act of 1993, as
amended, based on the average of the high and low prices of the Company's
Common Stock on September 23, 2002.
TABLE OF CONTENTS
PART II INFORMATION REQUIRED IN THE REGISTRATION STATEMENT
Item 3. Incorporation of Documents by Reference
Item 4. Description of Securities
Item 5. Interests of Named Experts and Counsel
Item 6. Indemnification of Directors and Officers
Item 7. Exemption From Registration Claimed
Item 8. Exhibits
Item 9. Undertakings
SIGNATURE
EXHIBIT INDEX
EXHIBIT 5.1
EXHIBIT 23.1
EXHIBIT 23.2
Table of Contents
PART II
INFORMATION REQUIRED IN THE REGISTRATION STATEMENT
Item 3. Incorporation of Documents by Reference
The following documents filed with the Securities and Exchange Commission
(the "Commission") by Genetronics Biomedical Corporation (the "Company") are
incorporated by reference in this Registration Statement:
a. our latest annual report on Form 10-K for the transition period ended
December 31, 2001;
b. our quarterly report on Form 10-Q for the quarter ended March 31, 2002;
c. our quarterly report on Form 10-Q for the quarter ended June 30, 2002;
d. our Form 8-K filed February 22, 2002 (as amended by Amendment No. 1 to
Form 8-K filed on March 12, 2002 and Amendment No. 2 to Form 8-K filed on March
25, 2002);
e. our Form 8-K filed March 22, 2002 (as amended by Amendment No. 1 to
Form 8-K filed March 28, 2002);
f. our Form 8-K filed May 24, 2002;
g. our Form 8-K filed June 14, 2002;
h. our Form 8-K filed August 19, 2002; and
i. the description of the Company's common stock contained in our Form S-4
filed March 14, 2001.
All documents filed by the Company with the Commission pursuant to
Sections 13(a), 13(c), 14 or 15(d) of the Exchange Act after the date of this
Registration Statement and prior to the filing of a post-effective amendment
which indicates that all shares of Common Stock offered pursuant to this
Registration Statement have been sold or that deregisters all shares of Common
Stock then remaining unsold, shall be deemed to be incorporated by reference in
this Registration Statement and to be a part hereof from the date of filing of
such documents.
Item 4. Description of Securities
The class of securities to be offered is registered under Section 12 of
the Exchange Act.
Item 5. Interests of Named Experts and Counsel
Inapplicable.
Item 6. Indemnification of Directors and Officers
Section 102(b) of the Delaware General Corporation Law authorizes a
corporation to provide in its Certificate of Incorporation that a director of
the corporation shall not be personally liable to the corporation or its
stockholders for monetary damages for breach or alleged breach of the
director's "duty of care." While this statute does not change the directors'
duty of care, it enables corporations to limit available relief to equitable
remedies such as injunction or rescission. The statute has no effect on a
director's duty of loyalty or liability for acts or omissions not in good faith
or involving intentional misconduct or knowing violations of law, illegal
payment of dividends or stock redemptions or repurchases, or for any
transaction from which the director derives an improper personal benefit.
As permitted by the statute, we have adopted provisions in our Certificate
of Incorporation which eliminate to the fullest extent permissible under
Delaware law the personal liability of our directors to us and to our
stockholders for monetary damages for breach or alleged breach of the duty of
care.
Table of Contents
Section 145 of the Delaware General Corporation Law provides generally
that a corporation shall have the power, and in some cases is required, to
indemnify an agent, including an officer or director, who was or is a party or
is threatened to be made a party to any threatened, pending or completed
action, suit or proceeding, whether civil, criminal, administrative or
investigative (other than an action by or in the right of the corporation) by
reason of the fact that he or she is or was a director, officer, employee or
agent of the corporation, against certain expenses, judgments, fines,
settlements, and other amounts under certain circumstances.
Our Bylaws provide for indemnification (to the full extent permitted by
the Delaware General Corporation Law) of directors, officers, employees and
other agents of the Company against all expenses, liability and loss (including
attorney's fees, judgment, fines, ERISA excise taxes or penalties, amounts paid
or to be paid in settlement and amounts expended in seeking indemnification
granted to such person under applicable law, the Bylaws or any agreement with
us) reasonably incurred or suffered by such person in connection therewith,
subject to certain provisions. Our Bylaws also empower us to maintain directors
and officers liability insurance coverage and to enter into indemnification
agreements with our directors, officers, employees or agents.
These indemnification provisions may be sufficiently broad to permit
indemnification of the Company's officers and directors for liabilities
(including reimbursement of expenses incurred) arising under the Securities
Act.
Item 7. Exemption From Registration Claimed
Inapplicable.
Item 8. Exhibits
See Exhibit Index.
Item 9. Undertakings
(a)  The undersigned registrant hereby undertakes:
(1)  To file, during any period in which offers or sales are being made, a
post-effective amendment to this registration statement:
(i)  To include any prospectus required by Section 10(a)(3) of the
Securities Act of 1933;
(ii)  To reflect in the prospectus any facts or events arising after the
effective date of the registration statement (or the most recent post-effective
amendment thereof) which, individually or in the aggregate, represent a
fundamental change in the information set forth in the registration statement.
Notwithstanding the foregoing, any increase or decrease in volume of securities
offered (if the total dollar value of securities offered would not exceed that
which was registered) and any deviation from the low or high end of the
estimated maximum offering range may be reflected in the form of prospectus
filed with the Commission pursuant to Rule 424(b) if, in the aggregate, the
changes in volume and price represent no more than a 20% change in the maximum
aggregate offering price set forth in the "Calculation of Registration Fee"
table in the effective registration statement;
(iii)  To include any material information with respect to the plan of
distribution not previously disclosed in the registration statement or any
material change to such information in the registration statement; provided,
however, that paragraphs (a)(1)(i) and (a)(l)(ii) do not apply if the
registration statement is on Form S-3 or Form S-8, and the information required
to be included in a post-effective amendment by those paragraphs is contained
in periodic reports filed by the registrant pursuant to Section 13 or Section
15(d) of the Exchange Act that are incorporated by reference in the
registration statement.
(2)  That, for the purpose of determining any liability under the Securities Act
of 1933, each such post-effective amendment shall be deemed to be a new
registration statement relating to the securities offered therein, and the
offering of such securities at that time shall be deemed to be the initial bona
fide offering thereof.
Table of Contents
(3)  To remove from registration by means of a post-effective amendment any of
the securities being registered which remain unsold at the termination of the
offering.
(b)  The undersigned registrant hereby undertakes that, for purposes of
determining any liability under the Securities Act of 1933, each filing of the
registrant's annual report pursuant to Section 13(a) or Section 15(d) of the
Exchange Act (and, where applicable, each filing of an employee benefit plan's
annual report pursuant to Section 15(d) of the Exchange Act) that is
incorporated by reference in the registration statement shall be deemed to be a
new registration statement relating to the securities offered therein, and the
offering of such securities at that time shall be deemed to be the initial bona
fide offering thereof.
(c)  Insofar as indemnification for liabilities arising under the
Securities Act of 1933 may be permitted to directors, officers and controlling
persons of the registrant pursuant to the foregoing provisions, or otherwise,
the registrant has been advised that in the opinion of the Securities and
Exchange Commission such indemnification is against public policy as expressed
in the Act and is, therefore, unenforceable. In the event that a claim for
indemnification against such liabilities (other than the payment by the
registrant of expenses incurred or paid by a director, officer or controlling
person of the registrant in the successful defense of any action, suit or
proceeding) is asserted by such director, officer or controlling person in
connection with the securities being registered, the registrant will, unless in
the opinion of its counsel the matter has been settled by controlling
precedent, submit to a court of appropriate jurisdiction the question whether
such indemnification by it is against public policy as expressed in the Act and
will be governed by the final adjudication of such issue.
SIGNATURE
Pursuant to the requirements of the Securities Act of 1933, as amended,
the registrant certifies that it has reasonable grounds to believe that it
meets all of the requirements for filing on Form S-8 and has duly caused this
registration statement to be signed on its behalf by the undersigned, thereunto
duly authorized, in the City of San Diego, State of California, on
September 25, 2002.
Genetronics Biomedical Corporation
By:
/s/ Avtar Dhillon
Avtar Dhillon
President and Chief Executive Officer
Table of Contents
POWER OF ATTORNEY
The officers and directors of Genetronics Biomedical Corporation whose
signatures appear below, hereby constitute and appoint Avtar Dhillon and Peter
Kies, and each of them, their true and lawful attorneys and agents, with full
power of substitution, each with power to act alone, to sign and execute on
behalf of the undersigned any amendment or amendments to this registration
statement on Form S-8, and each of the undersigned does hereby ratify and
confirm all that each of said attorney and agent, or their, her or his
substitutes, shall do or cause to be done by virtue hereof.
Pursuant to the requirements of the Securities Act of 1933, as amended,
this registration statement has been signed by the following persons in the
capacities indicated on September 25, 2002.
Signature
Title
/s/ Avtar Dhillon
Avtar Dhillon
President, Chief Executive Officer (Principal Executive
Officer) and Director
/s/ Peter D. Kies
Peter D. Kies
Chief Financial Officer (Principal Financial and Accounting
Officer)
/s/ James L. Heppell
James L. Heppell
Director
/s/ Felix Theeuwes
Felix Theeuwes
Director
/s/ Tazdin Esmail
Tazdin Esmail
Director
Table of Contents
EXHIBIT INDEX
Ex.#
Description
4.1*
Certificate of Incorporation
4.2**
Bylaws, as amended
4.3***
Shareholder Rights Agreement, dated June 30, 1997 by and between the Company
and Montreal Trust Company of Canada, as amended on August 27, 1997
5.1
Opinion and Consent of Gray Cary Ware & Freidenrich LLP
23.1
Consent of Ernst & Young LLP (San Diego, United States), Independent Auditors
23.2
Consent of Ernst & Young LLP (Vancouver, Canada), Independent Auditors
24.1
Power of Attorney (See Signature Page)
*
Incorporated by reference from the Form S-4 (333-56978) filed on April 5, 2001.
**
Incorporated by reference from the Form 10-Q for the period ended September 30, 2001.
***
Filed as an exhibit to Company's Form S-1 (333-76738) and incorporated by reference herein.