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<TITLE>Discovery Partners International, Inc.</TITLE>
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<P align="center"><FONT size="2">As filed with the Securities and Exchange Commission on July&nbsp;26, 2002</FONT>

<P align="right"><FONT size="2">Registration No.&nbsp;333-____________</FONT>

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<P align="center"><FONT size="2"><B>SECURITIES AND EXCHANGE COMMISSION</B><BR>
Washington, D.C. 20549</FONT>

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<P align="center"><FONT size="2"><B>FORM S-8<BR>
REGISTRATION STATEMENT</B><BR>
<I>Under<BR>
The Securities Act of 1933</I></FONT>

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<P align="center"><FONT size="2"><B>DISCOVERY PARTNERS INTERNATIONAL, INC.</B><BR>
(Exact name of registrant as specified in its charter)</FONT>

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        <TD width="50%">&nbsp;</TD>
        <TD width="5%">&nbsp;</TD>
        <TD width="45%">&nbsp;</TD>
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<TR valign="bottom">
        <TD align="center" valign="top"><FONT size="2"><B>Delaware</B><BR>
(State or other jurisdiction<BR>
of incorporation or organization)</FONT></TD>
        <TD><FONT size="2">&nbsp;</FONT></TD>
        <TD align="center" valign="top"><FONT size="2">
<B>33-0655706</B><BR>
(IRS Employer Identification No.)</FONT></TD>
</TR>
</TABLE>
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<P align="center"><FONT size="2"><B>9640 Towne Centre Drive<BR>
San Diego, California 92121</B><BR>
(Address of principal executive offices) (Zip Code)</FONT>

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<P align="center"><FONT size="2"><B>DISCOVERY PARTNERS INTERNATIONAL, INC.<BR>
2000 Stock Incentive Plan<BR>
Employee Stock Purchase Plan</B><BR>
(Full title of the Plans)</FONT>

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<P align="center"><FONT size="2"><B>Mr.&nbsp;Riccardo Pigliucci<BR>
Chief Executive Officer<BR>
DISCOVERY PARTNERS INTERNATIONAL, INC.<BR>
9640 Towne Centre Drive<BR>
San Diego, California 92121</B><BR>
(Name and address of agent for service)<BR>
<B>(858)&nbsp;455-8600</B><BR>
(Telephone number, including area code, of agent for service)</FONT>

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<P align="center"><FONT size="2"><B>CALCULATION OF REGISTRATION FEE</B></FONT>

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        <TD width="40%">&nbsp;</TD>
        <TD width="3%">&nbsp;</TD>
        <TD width="7%">&nbsp;</TD>
        <TD width="1%">&nbsp;</TD>
        <TD width="7%">&nbsp;</TD>
        <TD width="3%">&nbsp;</TD>
        <TD width="3%">&nbsp;</TD>
        <TD width="1%">&nbsp;</TD>
        <TD width="4%">&nbsp;</TD>
        <TD width="3%">&nbsp;</TD>
        <TD width="9%">&nbsp;</TD>
        <TD width="1%">&nbsp;</TD>
        <TD width="9%">&nbsp;</TD>
        <TD width="3%">&nbsp;</TD>
        <TD width="2%">&nbsp;</TD>
        <TD width="1%">&nbsp;</TD>
        <TD width="3%">&nbsp;</TD>
</TR>
<TR valign="bottom">
        <TD><FONT size="1">&nbsp;</FONT></TD>
        <TD><FONT size="1">&nbsp;</FONT></TD>
        <TD><FONT size="1">&nbsp;</FONT></TD>
        <TD><FONT size="1">&nbsp;</FONT></TD>
        <TD><FONT size="1">&nbsp;</FONT></TD>
        <TD><FONT size="1">&nbsp;</FONT></TD>
        <TD nowrap align="center" colspan="3"><FONT size="1">Proposed</FONT></TD>
        <TD><FONT size="1">&nbsp;</FONT></TD>
        <TD nowrap align="center" colspan="3"><FONT size="1">Proposed</FONT></TD>
        <TD><FONT size="1">&nbsp;</FONT></TD>
        <TD><FONT size="1">&nbsp;</FONT></TD>
        <TD><FONT size="1">&nbsp;</FONT></TD>
        <TD><FONT size="1">&nbsp;</FONT></TD>
</TR>
<TR valign="bottom">
        <TD nowrap align="center"><FONT size="1">Title of</FONT></TD>
        <TD><FONT size="1">&nbsp;</FONT></TD>
        <TD><FONT size="1">&nbsp;</FONT></TD>
        <TD><FONT size="1">&nbsp;</FONT></TD>
        <TD><FONT size="1">&nbsp;</FONT></TD>
        <TD><FONT size="1">&nbsp;</FONT></TD>
        <TD nowrap align="center" colspan="3"><FONT size="1">Maximum</FONT></TD>
        <TD><FONT size="1">&nbsp;</FONT></TD>
        <TD nowrap align="center" colspan="3"><FONT size="1">Maximum</FONT></TD>
        <TD><FONT size="1">&nbsp;</FONT></TD>
        <TD><FONT size="1">&nbsp;</FONT></TD>
        <TD><FONT size="1">&nbsp;</FONT></TD>
        <TD><FONT size="1">&nbsp;</FONT></TD>
</TR>
<TR valign="bottom">
        <TD nowrap align="center"><FONT size="1">Securities</FONT></TD>
        <TD><FONT size="1">&nbsp;</FONT></TD>
        <TD nowrap align="center" colspan="3"><FONT size="1">Amount</FONT></TD>
        <TD><FONT size="1">&nbsp;</FONT></TD>
        <TD nowrap align="center" colspan="3"><FONT size="1">Offering</FONT></TD>
        <TD><FONT size="1">&nbsp;</FONT></TD>
        <TD nowrap align="center" colspan="3"><FONT size="1">Aggregate</FONT></TD>
        <TD><FONT size="1">&nbsp;</FONT></TD>
        <TD nowrap align="center" colspan="3"><FONT size="1">Amount of</FONT></TD>
</TR>
<TR valign="bottom">
        <TD nowrap align="center"><FONT size="1">to be</FONT></TD>
        <TD><FONT size="1">&nbsp;</FONT></TD>
        <TD nowrap align="center" colspan="3"><FONT size="1">to be</FONT></TD>
        <TD><FONT size="1">&nbsp;</FONT></TD>
        <TD nowrap align="center" colspan="3"><FONT size="1">Price</FONT></TD>
        <TD><FONT size="1">&nbsp;</FONT></TD>
        <TD nowrap align="center" colspan="3"><FONT size="1">Offering</FONT></TD>
        <TD><FONT size="1">&nbsp;</FONT></TD>
        <TD nowrap align="center" colspan="3"><FONT size="1">Registration</FONT></TD>
</TR>
<TR valign="bottom">
        <TD nowrap align="center"><FONT size="1">Registered</FONT></TD>
        <TD><FONT size="1">&nbsp;</FONT></TD>
        <TD nowrap align="center" colspan="3"><FONT size="1">Registered(1)</FONT></TD>
        <TD><FONT size="1">&nbsp;</FONT></TD>
        <TD nowrap align="center" colspan="3"><FONT size="1">per Share</FONT></TD>
        <TD><FONT size="1">&nbsp;</FONT></TD>
        <TD nowrap align="center" colspan="3"><FONT size="1">Price(2)</FONT></TD>
        <TD><FONT size="1">&nbsp;</FONT></TD>
        <TD nowrap align="center" colspan="3"><FONT size="1">Fee</FONT></TD>
</TR>
<TR valign="bottom">
        <TD nowrap align="center"><HR size="1" noshade></TD>
        <TD><FONT size="1">&nbsp;</FONT></TD>
        <TD colspan="3"><HR size="1" noshade></TD>
        <TD><FONT size="1">&nbsp;</FONT></TD>
        <TD colspan="3"><HR size="1" noshade></TD>
        <TD><FONT size="1">&nbsp;</FONT></TD>
        <TD colspan="3"><HR size="1" noshade></TD>
        <TD><FONT size="1">&nbsp;</FONT></TD>
        <TD colspan="3"><HR size="1" noshade></TD>
</TR>
<TR valign="bottom">
        <TD><FONT size="2">2000 Stock Incentive Plan<BR>
Common Stock, $0.001 par value</FONT></TD>
        <TD><FONT size="2">&nbsp;</FONT></TD>
        <TD colspan="3" align="center"><FONT size="2">963,867 shares</FONT></TD>
        <TD><FONT size="2">&nbsp;</FONT></TD>
        <TD nowrap align="right"><FONT size="2">$</FONT></TD>
        <TD align="right"><FONT size="2">3.62</FONT></TD>
        <TD nowrap><FONT size="2">(2)</FONT></TD>
        <TD><FONT size="2">&nbsp;</FONT></TD>
        <TD nowrap align="right"><FONT size="2">$</FONT></TD>
        <TD align="right"><FONT size="2">3,489,198.54</FONT></TD>
        <TD nowrap><FONT size="2">(2)</FONT></TD>
        <TD><FONT size="2">&nbsp;</FONT></TD>
        <TD align="right"><FONT size="2">$</FONT></TD>
        <TD align="right"><FONT size="2">321.01</FONT></TD>
        <TD><FONT size="2">&nbsp;</FONT></TD>
</TR>
<TR valign="bottom">
        <TD><FONT size="2">2000 Employee Stock Purchase Plan<BR>
Common Stock, $0.001 par value</FONT></TD>
        <TD><FONT size="2">&nbsp;</FONT></TD>
        <TD colspan="3" align="center"><FONT size="2">722,900 shares</FONT></TD>
        <TD><FONT size="2">&nbsp;</FONT></TD>
        <TD nowrap align="right"><FONT size="2">$</FONT></TD>
        <TD align="right"><FONT size="2">3.62</FONT></TD>
        <TD nowrap><FONT size="2">(2)</FONT></TD>
        <TD><FONT size="2">&nbsp;</FONT></TD>
        <TD nowrap align="right"><FONT size="2">$</FONT></TD>
        <TD align="right"><FONT size="2">2,616,898.00</FONT></TD>
        <TD nowrap><FONT size="2">(2)</FONT></TD>
        <TD><FONT size="2">&nbsp;</FONT></TD>
        <TD align="right"><FONT size="2">$</FONT></TD>
        <TD align="right"><FONT size="2">240.75</FONT></TD>
        <TD><FONT size="2">&nbsp;</FONT></TD>
</TR>

<TR valign="bottom">
        <TD colspan="13" align="right"><FONT size="2">Aggregate Registration Fee</FONT></TD>
        <TD><FONT size="2">&nbsp;</FONT></TD>
        <TD align="right"><FONT size="2">$</FONT></TD>
        <TD align="right"><FONT size="2">561.76</FONT></TD>
        <TD><FONT size="2">&nbsp;</FONT></TD>
</TR>
</TABLE>
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<P>
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<TR valign="top">
      <TD width="1%" align="left" nowrap><FONT size="2">(1)</FONT></TD>
        <TD width="3%"><FONT size="2">&nbsp;</FONT></TD>
        <TD width="96%"><FONT size="2">This Registration Statement shall also cover any additional shares of
Registrant&#146;s Common Stock which become issuable under the Registrant&#146;s.
2000 Stock Incentive Plan and the 2000 Employee Stock Purchase Plan by
reason of any stock dividend, stock split, recapitalization or other
similar transaction effected without the Registrant&#146;s receipt of
consideration which results in an increase in the number of the
outstanding shares of Registrant&#146;s Common Stock.</FONT></TD>
</TR>
<TR><TD><TR><TD><TR><TD><TR><TD>
<TR valign="top">
      <TD width="1%" align="left" nowrap><FONT size="2">(2)</FONT></TD>
        <TD width="3%"><FONT size="2">&nbsp;</FONT></TD>
        <TD width="96%"><FONT size="2">Calculated solely for purposes of this offering under Rule&nbsp;457(h) of the
Securities Act of 1933, as amended, on the basis of the average of the
high and low selling price per share of Registrant&#146;s Common Stock on July
24, 2002, as reported by the Nasdaq National Market.</FONT></TD>
</TR>
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<P align="center"><FONT size="2">&nbsp;
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<A name="toc"><DIV align="CENTER" style="page-break-before:always"><U><B>TABLE OF CONTENTS</B></U></DIV></A>

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<TR><TD colspan="9"><A HREF="#000">PART II Information Required in the Registration Statement</A></TD></TR>
<TR><TD></TD><TD colspan="8"><A HREF="#001">Item&nbsp;3. Incorporation of Documents by Reference</A></TD></TR>
<TR><TD></TD><TD colspan="8"><A HREF="#002">Item&nbsp;4. Description of Securities</A></TD></TR>
<TR><TD></TD><TD colspan="8"><A HREF="#003">Item&nbsp;5. Interests of Named Experts and Counsel</A></TD></TR>
<TR><TD></TD><TD colspan="8"><A HREF="#004">Item&nbsp;6. Indemnification of Directors and Officers</A></TD></TR>
<TR><TD></TD><TD colspan="8"><A HREF="#005">Item&nbsp;7. Exemption from Registration Claimed</A></TD></TR>
<TR><TD></TD><TD colspan="8"><A HREF="#006">Item&nbsp;8. Exhibits</A></TD></TR>
<TR><TD></TD><TD colspan="8"><A HREF="#007">Item&nbsp;9. Undertakings</A></TD></TR>
<TR><TD colspan="9"><A HREF="#008">SIGNATURES</A></TD></TR>
<TR><TD colspan="9"><A HREF="#009">EXHIBIT INDEX</A></TD></TR>
<TR><TD colspan="9"><A HREF="a83147exv5w1.txt">EXHIBIT 5.1</A></TD></TR>
<TR><TD colspan="9"><A HREF="a83147exv23w1.txt">EXHIBIT 23.1</A></TD></TR>
<TR><TD colspan="9"><A HREF="a83147exv99w1.txt">EXHIBIT 99.1</A></TD></TR>
<TR><TD colspan="9"><A HREF="a83147exv99w2.txt">EXHIBIT 99.2</A></TD></TR>
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<DIV align="left"><A NAME="000"></A></DIV>
<P align="center"><FONT size="2"><B>PART II</B></FONT>

<P align="center"><FONT size="2"><B>Information Required in the Registration Statement</B></FONT>

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<DIV align="left"><A NAME="001"></A></DIV>
<P align="left"><FONT size="2">Item&nbsp;3. Incorporation of Documents by Reference</FONT>

<P><FONT size="2">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Discovery Partners International, Inc. (the &#147;Registrant&#148;) hereby
incorporates by reference into this Registration Statement the following
documents previously filed with the Securities and Exchange Commission (the
&#147;Commission&#148;):
</FONT>
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   <TD width="1%" nowrap><FONT size="2">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</FONT></TD>
   <TD width="1%" align="right" nowrap><FONT size="2">(a)</FONT></TD>
   <TD width="1%" nowrap><FONT size="2">&nbsp;&nbsp;</FONT></TD>
   <TD width="97%"><FONT size="2">The Registrant&#146;s Annual Report on Form&nbsp;10-K for the fiscal
year ended December&nbsp;31, 2001 filed with the Commission on March&nbsp;29,
2002;</FONT></TD>
</TR>
<TR>
        <TD><FONT size="2">&nbsp;</FONT></TD>
</TR>
<TR valign="top">
   <TD width="1%" nowrap><FONT size="2">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</FONT></TD>
   <TD width="1%" align="right" nowrap><FONT size="2">(b)</FONT></TD>
   <TD width="1%" nowrap><FONT size="2">&nbsp;&nbsp;</FONT></TD>
   <TD width="97%"><FONT size="2">The Registrant&#146;s Quarterly Report on Form&nbsp;10-Q for the fiscal
quarter ended March&nbsp;31, 2001 filed with the Commission on May&nbsp;13,
2002;</FONT></TD>
</TR>
<TR>
        <TD><FONT size="2">&nbsp;</FONT></TD>
</TR>
<TR valign="top">
   <TD width="1%" nowrap><FONT size="2">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</FONT></TD>
   <TD width="1%" align="right" nowrap><FONT size="2">(c)</FONT></TD>
   <TD width="1%" nowrap><FONT size="2">&nbsp;&nbsp;</FONT></TD>
   <TD width="97%"><FONT size="2">The Registrant&#146;s Registration Statement No.&nbsp;000-31141 on Form
8-A filed with the Commission on July&nbsp;25, 2000 pursuant to Section
12(g) of the Securities Exchange Act of 1934 (the &#147;1934 Act&#148;), in
which there is described the terms, rights, and provisions
applicable to the Registrant&#146;s outstanding Common Stock.</FONT></TD>
</TR>
</TABLE>
<P><FONT size="2">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;All reports and definitive proxy or information statements filed pursuant
to Section&nbsp;13(a), 13(c), 14 or 15(d) of the 1934 Act, after the date of this
Registration Statement and prior to the filing of a post-effective amendment
which indicates that all securities offered hereby have been sold or which
de-registers all securities then remaining unsold shall be deemed to be
incorporated by reference into this Registration Statement and to be a part
hereof from the date of filing of such documents. Any statement contained in a
document incorporated or deemed to be incorporated by reference herein shall be
deemed to be modified or superseded for purposes of this Registration Statement
to the extent that a statement contained herein or in any subsequently filed
document which also is deemed to be incorporated by reference herein modifies
or supersedes such statement. Any such statement so modified or superseded
shall not be deemed, except as so modified or superseded, to constitute a part
of this Registration Statement.
</FONT>
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<DIV align="left"><A NAME="002"></A></DIV>
<P align="left"><FONT size="2">Item&nbsp;4. Description of Securities</FONT>

<P><FONT size="2">Not Applicable.
</FONT>
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<DIV align="left"><A NAME="003"></A></DIV>
<P align="left"><FONT size="2">Item&nbsp;5. Interests of Named Experts and Counsel</FONT>

<P><FONT size="2">Not Applicable.
</FONT>
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<DIV align="left"><A NAME="004"></A></DIV>
<P align="left"><FONT size="2">Item&nbsp;6. Indemnification of Directors and Officers</FONT>

<P><FONT size="2">Section&nbsp;145 of the Delaware Corporation Law provides that a Delaware
corporation may indemnify any person against expenses, judgments, fines
and settlements actually and reasonably incurred by any such person in
connection with a threatened, pending or completed action, suit or
proceeding in which such person is involved by reason of the fact that
such person is or was a director, officer, employee or agent of such
corporation, provided that (i)&nbsp;such person acted in good faith and in a
manner reasonably believed to be in or not opposed to the best interests
of the corporation and (ii)&nbsp;with respect to any criminal action or
proceeding, such person had no reasonable cause to believe such person&#146;s
conduct was unlawful. If the action or suit is by or in the name of the
corporation, the corporation may indemnify any such person against
expenses actually and reasonably incurred by such person in connection
with the defense or settlement of such action or suit if such person
acted in good faith and in a manner such person reasonably believed to be
in or not opposed to the best interests of the corporation, except that
no indemnification may be made in respect to any claim, issue or matter
as to which such person shall have been adjudged to be liable to the
corporation for negligence or misconduct in the performance of such
person&#146;s duty to the
</FONT>
<P align="center"><FONT size="2">II-1
</FONT>

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<P><FONT size="2"> corporation, unless and only to the extent that the Delaware Court of
Chancery or the court in which the action or suit is brought determines
upon application that, despite the adjudication of liability but in view
of all of the circumstances of the case, such person is fairly and
reasonably entitled to indemnity for such expenses as the court deems
proper.
</FONT>
<P><FONT size="2">The Registrant&#146;s certificate of incorporation limits the liability of
directors to the maximum extent permitted by Delaware law.
</FONT>
<P><FONT size="2">The Registrant&#146;s certificate of incorporation and bylaws provide that the
Registrant shall indemnify its directors and executive officers and may
indemnify its other officers and employees and other agents to the
fullest extent permitted by law. The Registrant believes that
indemnification under its bylaws covers at least negligence and gross
negligence on the part of the indemnified parties. The Registrant&#146;s
bylaws also permit it to secure insurance on behalf of any officer,
director, employee or other agent for any liability arising out of his or
her actions in such capacity, regardless of whether the bylaws would
permit indemnification.
</FONT>
<P><FONT size="2">In addition to indemnification provided for in its certificate of
incorporation and bylaws, the Registrant has entered into agreements to
indemnify its directors and executive officers. The agreements, among
other things, provide for indemnification of the Registrant&#146;s directors
and executive officers for expenses specified in the agreements,
including attorneys&#146; fees, judgments, fines and settlement amounts
incurred by the Registrant&#146;s directors or executive officers in any
action or proceeding arising out of that person&#146;s services as a director
or executive officer of the Registrant, any subsidiary of the Registrant
or any other entity to which the person provides services at the
Registrant&#146;s request. In addition, the Registrant maintains directors&#146;
and officers&#146; insurance. The Registrant believes that all of the
foregoing provisions and agreements are necessary to attract and retain
qualified persons as directors and executive officers.
</FONT>
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<DIV align="left"><A NAME="005"></A></DIV>
<P align="left"><FONT size="2">Item&nbsp;7. Exemption from Registration Claimed</FONT>

<P><FONT size="2">Not Applicable.
</FONT>
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<DIV align="left"><A NAME="006"></A></DIV>
<P align="left"><FONT size="2">Item&nbsp;8. Exhibits</FONT>

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        <TD width="8%">&nbsp;</TD>
        <TD width="5%">&nbsp;</TD>
        <TD width="87%">&nbsp;</TD>
</TR>
<TR valign="bottom">
        <TD nowrap align="center"><FONT size="1">Exhibit Number</FONT></TD>
        <TD><FONT size="1">&nbsp;</FONT></TD>
        <TD nowrap align="left"><FONT size="1">Exhibit</FONT></TD>
</TR>
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        <TD nowrap align="center"><HR size="1" noshade></TD>
        <TD><FONT size="1">&nbsp;</FONT></TD>
        <TD nowrap align="center"><HR size="1" noshade></TD>
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<TR valign="bottom">
        <TD valign="top"><FONT size="2">4.1</FONT></TD>
        <TD><FONT size="2">&nbsp;</FONT></TD>
        <TD align="left" valign="top"><FONT size="2">
Instruments Defining the Rights of Stockholders. Reference is made to
Registrant&#146;s Registration Statement No.&nbsp;000-31141 on Form&nbsp;8-A, together
with the exhibits thereto, which are incorporated herein by reference
pursuant to Item&nbsp;3(c) to this Registration Statement.</FONT></TD>
</TR>

<TR valign="bottom">
        <TD valign="top"><FONT size="2">5.1</FONT></TD>
        <TD><FONT size="2">&nbsp;</FONT></TD>
        <TD align="left" valign="top"><FONT size="2">
Opinion and Consent of Brobeck, Phleger &#038; Harrison LLP.</FONT></TD>
</TR>

<TR valign="bottom">
        <TD valign="top"><FONT size="2">23.1</FONT></TD>
        <TD><FONT size="2">&nbsp;</FONT></TD>
        <TD align="left" valign="top"><FONT size="2">
Consent of Ernst &#038; Young, LLP, Independent Auditors.</FONT></TD>
</TR>

<TR valign="bottom">
        <TD valign="top"><FONT size="2">23.2</FONT></TD>
        <TD><FONT size="2">&nbsp;</FONT></TD>
        <TD align="left" valign="top"><FONT size="2">
Consent of Brobeck, Phleger &#038; Harrison LLP is contained in Exhibit&nbsp;5.1</FONT></TD>
</TR>

<TR valign="bottom">
        <TD valign="top"><FONT size="2">24.1</FONT></TD>
        <TD><FONT size="2">&nbsp;</FONT></TD>
        <TD align="left" valign="top"><FONT size="2">
Power of Attorney. Reference is made to page II-4 of this Registration Statement.</FONT></TD>
</TR>

<TR valign="bottom">
        <TD valign="top"><FONT size="2">99.1</FONT></TD>
        <TD><FONT size="2">&nbsp;</FONT></TD>
        <TD align="left" valign="top"><FONT size="2">
2000 Stock Incentive Plan</FONT></TD>
</TR>

<TR valign="bottom">
        <TD valign="top"><FONT size="2">99.2</FONT></TD>
        <TD><FONT size="2">&nbsp;</FONT></TD>
        <TD align="left" valign="top"><FONT size="2">
2000 Employee Stock Purchase Plan.</FONT></TD>
</TR>
</TABLE>
</CENTER>
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<DIV align="left"><A NAME="007"></A></DIV>
<P align="left"><FONT size="2">Item&nbsp;9. Undertakings</FONT>

<P><FONT size="2">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;A.&nbsp;The undersigned Registrant hereby undertakes: (1)&nbsp;to file, during any
period in which offers or sales are being made, a post-effective amendment to
this Registration Statement: (i)&nbsp;to include any prospectus required by Section
10(a)(3) of the 1933 Act; (ii)&nbsp;to reflect in the prospectus any facts or events
arising after the effective date of this Registration Statement (or the most
recent post-effective amendment thereof) which, individually or in the
aggregate, represent a fundamental change in the information set forth in this
Registration Statement; and (iii)&nbsp;to include any material information with
respect to the plan of distribution not previously disclosed in this
Registration Statement or any material change to such information in this
Registration Statement; provided, however, that clauses (1)(i) and (1)(ii)
shall not apply if the information required to be included in a post-effective
amendment by those clauses is contained in periodic reports filed by the
Registrant pursuant to Section&nbsp;13 or Section&nbsp;15(d) of the 1934 Act that are
incorporated by reference into this Registration Statement; (2)&nbsp;that for the
</FONT>
<P align="center"><FONT size="2">II-2
</FONT>

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<H5 align="left" style="page-break-before:always"><A HREF="#toc">Table of Contents</A></H5><P>

<P><FONT size="2">purpose of determining any liability under the 1933 Act each such
post-effective amendment shall be deemed to be a new registration statement
relating to the securities offered therein and the offering of such securities
at that time shall be deemed to be the initial bona fide offering thereof; and
(3)&nbsp;to remove from registration by means of a post-effective amendment any of
the securities being registered which remain unsold at the termination of the
Registrant&#146;s 2000 Stock Incentive Plan or Employee Stock Purchase Plan.
</FONT>
<P><FONT size="2">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;B.&nbsp;The undersigned Registrant hereby undertakes that, for purposes of
determining any liability under the 1933 Act, each filing of the Registrant&#146;s
annual report pursuant to Section&nbsp;13(a) or Section&nbsp;15(d) of the 1934 Act that
is incorporated by reference into this Registration Statement shall be deemed
to be a new registration statement relating to the securities offered therein,
and the offering of such securities at that time shall be deemed to be the
initial bona fide offering thereof.
</FONT>
<P><FONT size="2">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;C.&nbsp;Insofar as indemnification for liabilities arising under the 1933 Act
may be permitted to directors, officers or controlling persons of the
Registrant pursuant to the indemnification provisions summarized in Item&nbsp;6 or
otherwise, the Registrant has been advised that, in the opinion of the
Commission, such indemnification is against public policy as expressed in the
1933 Act and is, therefore, unenforceable. In the event that a claim for
indemnification against such liabilities (other than the payment by the
Registrant of expenses incurred or paid by a director, officer, or controlling
person of the Registrant in the successful defense of any action, suit or
proceeding) is asserted by such director, officer or controlling person in
connection with the securities being registered, the Registrant will, unless in
the opinion of its counsel the matter has been settled by controlling
precedent, submit to a court of appropriate jurisdiction the question whether
such indemnification by it is against public policy as expressed in the 1933
Act and will be governed by the final adjudication of such issue.
</FONT>
<P align="center"><FONT size="2">II-3
</FONT>

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<!-- link1 "SIGNATURES" -->
<DIV align="left"><A NAME="008"></A></DIV>
<P align="center"><FONT size="2"><B>SIGNATURES</B></FONT>

<P><FONT size="2">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Pursuant to the requirements of the Securities Act of 1933, as amended,
the Registrant certifies that it has reasonable grounds to believe that it
meets all of the requirements for filing on Form&nbsp;S-8, and has duly caused this
Registration Statement to be signed on its behalf by the undersigned, thereunto
duly authorized, in the City of San Diego, State of California, on this 26th
day of July, 2002.
</FONT>
<TABLE cellspacing="0" border="0" cellpadding="0" width="100%">
<TR>
        <TD width="50%">&nbsp;</TD>
        <TD width="1%">&nbsp;</TD>
        <TD width="49%">&nbsp;</TD>
</TR>
<TR>
        <TD><FONT size="2">&nbsp;</FONT></TD>
        <TD colspan="2"><FONT size="2"><B>DISCOVERY PARTNERS INTERNATIONAL, INC</B></FONT></TD>
</TR>

<TR><TD>&nbsp;<BR>&nbsp;</TD></TR>
<TR>
        <TD><FONT size="2">&nbsp;</FONT></TD>
        <TD><FONT size="2">By:&nbsp;</FONT></TD>
        <TD><FONT size="2">/s/ Riccardo Pigliucci</FONT></TD>
</TR>
<TR>
        <TD colspan="2"><FONT size="1">&nbsp;</FONT></TD>
        <TD><HR size="1" noshade color="#000000"></TD>
</TR>
<TR valign="top">
        <TD colspan="2">&nbsp;</TD>
        <TD><FONT size="2">
Riccardo Pigliucci<BR>
Chief Executive Officer</FONT></TD>
</TR>
</TABLE>

<P align="center"><FONT size="2"><B>POWER OF ATTORNEY</B></FONT>

<P align="left"><FONT size="2"><B>KNOW ALL PERSONS BY THESE PRESENTS:</B></FONT>

<P><FONT size="2">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;That each person whose signature appears below constitutes and appoints
Riccardo Pigliucci, Chief Executive Officer, and Chairman of the Board, and
Craig S. Kussman, Chief Financial Officer, Vice President Finance and
Administration, and Secretary, and each of them, as such person&#146;s true and
lawful attorneys-in-fact and agents, with full power of substitution and
resubstitution, for such person and in such person&#146;s name, place and stead, in
any and all capacities, to sign any and all amendments (including
post-effective amendments) to this Registration Statement, and to file same,
with all exhibits thereto, and other documents in connection therewith, with
the Securities and Exchange Commission, granting unto said attorneys-in-fact
and agents, and each of them, full power and authority to do and perform each
and every act and thing requisite and necessary to be done in connection
therewith, as fully to all intents and purposes as such person might or could
do in person, hereby ratifying and confirming all that said attorneys-in-fact
and agents, or any of them, or their or his or her substitutes, may lawfully do
or cause to be done by virtue thereof. This Power of Attorney may be signed in
several counterparts.
</FONT>
<P><FONT size="2">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Pursuant to the requirements of the Securities Act of 1933, as amended,
this Registration Statement has been signed below by the following persons on
behalf of the Registrant and in the capacities and on the dates indicated:
</FONT>
<CENTER>
<TABLE cellspacing="0" border="0" cellpadding="0" width="100%">
<TR valign="bottom">
        <TD width="42%">&nbsp;</TD>
        <TD width="5%">&nbsp;</TD>
        <TD width="36%">&nbsp;</TD>
        <TD width="5%">&nbsp;</TD>
        <TD width="12%">&nbsp;</TD>
</TR>
<TR valign="bottom">
        <TD nowrap align="left"><FONT size="1">Signature</FONT></TD>
        <TD><FONT size="1">&nbsp;</FONT></TD>
        <TD nowrap align="left"><FONT size="1">Title</FONT></TD>
        <TD><FONT size="1">&nbsp;</FONT></TD>
        <TD nowrap align="left"><FONT size="1">Date</FONT></TD>
</TR>
<TR valign="bottom">
        <TD nowrap align="center"><HR size="1" noshade></TD>
        <TD><FONT size="1">&nbsp;</FONT></TD>
        <TD nowrap align="center"><HR size="1" noshade></TD>
        <TD><FONT size="1">&nbsp;</FONT></TD>
        <TD nowrap align="center"><HR size="1" noshade></TD>
</TR>
<TR><TD>&nbsp;</TD></TR>
<TR valign="bottom">
        <TD valign="top"><FONT size="2">/s/ Riccardo Pigliucci<BR>
</FONT><HR size="1" noshade><FONT size="2">
Riccardo Pigliucci</FONT></TD>
        <TD><FONT size="2">&nbsp;</FONT></TD>
        <TD align="left" valign="top"><FONT size="2">
Chief Executive Officer and
Chairman of<BR>the Board of
Directors (principal<BR>
executive officer)
</FONT></TD>
        <TD><FONT size="2">&nbsp;</FONT></TD>
        <TD align="left" valign="top"><FONT size="2">July 26, 2002</FONT></TD>
</TR>
<TR><TD><FONT size="2">&nbsp;</FONT></TD></TR>
<TR valign="bottom">
        <TD valign="top"><FONT size="2">/s/ Craig S. Kussman<BR>
</FONT><HR size="1" noshade><FONT size="2">
Craig S. Kussman</FONT></TD>
        <TD><FONT size="2">&nbsp;</FONT></TD>
        <TD align="left" valign="top"><FONT size="2">
Chief Financial Officer, Vice
President<BR>Finance and
Administration and Secretary<BR>
(principal financial and
accounting officer)
</FONT></TD>
        <TD><FONT size="2">&nbsp;</FONT></TD>
        <TD align="left" valign="top"><FONT size="2">July 26, 2002</FONT></TD>
</TR>
<TR><TD><FONT size="2">&nbsp;</FONT></TD></TR>
<TR valign="bottom">
        <TD valign="top"><FONT size="2">/s/ Harry F. Hixson, Jr., Ph.D.<BR>
</FONT><HR size="1" noshade><FONT size="2">
Harry F. Hixson, Jr., Ph.D.</FONT></TD>
        <TD><FONT size="2">&nbsp;</FONT></TD>
        <TD align="left" valign="top"><FONT size="2">
Director
</FONT></TD>
        <TD><FONT size="2">&nbsp;</FONT></TD>
        <TD align="left" valign="top"><FONT size="2">July 26, 2002</FONT></TD>
</TR>
<TR><TD><FONT size="2">&nbsp;</FONT></TD></TR>
<TR valign="bottom">
        <TD valign="top"><FONT size="2">/s/ Dieter Hoehn<BR>
</FONT><HR size="1" noshade><FONT size="2">
Dieter Hoehn</FONT></TD>
        <TD><FONT size="2">&nbsp;</FONT></TD>
        <TD align="left" valign="top"><FONT size="2">
Director
</FONT></TD>
        <TD><FONT size="2">&nbsp;</FONT></TD>
        <TD align="left" valign="top"><FONT size="2">July 26, 2002</FONT></TD>
</TR>
<TR><TD><FONT size="2">&nbsp;</FONT></TD></TR>
<TR valign="bottom">
        <TD valign="top"><FONT size="2">/s/ Sir Colin Dollery<BR>
</FONT><HR size="1" noshade><FONT size="2">
Sir Colin Dollery</FONT></TD>
        <TD><FONT size="2">&nbsp;</FONT></TD>
        <TD align="left" valign="top"><FONT size="2">
Director
</FONT></TD>
        <TD><FONT size="2">&nbsp;</FONT></TD>
        <TD align="left" valign="top"><FONT size="2">July 26, 2002</FONT></TD>
</TR>
</TABLE>
</CENTER>
<P align="center"><FONT size="2">II-4
</FONT>

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<CENTER>
<TABLE cellspacing="0" border="0" cellpadding="0" width="100%">
<TR valign="bottom">
        <TD width="42%">&nbsp;</TD>
        <TD width="5%">&nbsp;</TD>
        <TD width="36%">&nbsp;</TD>
        <TD width="5%">&nbsp;</TD>
        <TD width="12%">&nbsp;</TD>
</TR>
<TR valign="bottom">
        <TD nowrap align="left"><FONT size="1">Signature</FONT></TD>
        <TD><FONT size="1">&nbsp;</FONT></TD>
        <TD nowrap align="left"><FONT size="1">Title</FONT></TD>
        <TD><FONT size="1">&nbsp;</FONT></TD>
        <TD nowrap align="left"><FONT size="1">Date</FONT></TD>
</TR>
<TR valign="bottom">
        <TD nowrap align="center"><HR size="1" noshade></TD>
        <TD><FONT size="1">&nbsp;</FONT></TD>
        <TD nowrap align="center"><HR size="1" noshade></TD>
        <TD><FONT size="1">&nbsp;</FONT></TD>
        <TD nowrap align="center"><HR size="1" noshade></TD>
</TR>
<TR><TD><FONT size="2">&nbsp;</FONT></TD></TR>
<TR valign="bottom">
        <TD valign="top"><FONT size="2">/s/ John P. Walker<BR>
</FONT><HR size="1" noshade><FONT size="2">
John P. Walker</FONT></TD>
        <TD><FONT size="2">&nbsp;</FONT></TD>
        <TD align="left" valign="top"><FONT size="2">
Director
</FONT></TD>
        <TD><FONT size="2">&nbsp;</FONT></TD>
        <TD align="left" valign="top"><FONT size="2">July 26, 2002</FONT></TD>
</TR>
<TR><TD><FONT size="2">&nbsp;</FONT></TD></TR>
<TR valign="bottom">
        <TD valign="top"><FONT size="2">/s/ Alan J. Lewis, Ph.D.<BR>
</FONT><HR size="1" noshade><FONT size="2">
Alan J. Lewis, Ph.D.</FONT></TD>
        <TD><FONT size="2">&nbsp;</FONT></TD>
        <TD align="left" valign="top"><FONT size="2">
Director
</FONT></TD>
        <TD><FONT size="2">&nbsp;</FONT></TD>
        <TD align="left" valign="top"><FONT size="2">July 26, 2002</FONT></TD>
</TR>
</TABLE>
</CENTER>
<P align="center"><FONT size="2">II-5
</FONT>

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<P align="center"><FONT size="2">SECURITIES AND EXCHANGE COMMISSION</FONT>

<P align="center"><FONT size="2">WASHINGTON, D.C. 20549</FONT>

<P align="center"><FONT size="2">EXHIBITS</FONT>

<P align="center"><FONT size="2">TO</FONT>

<P align="center"><FONT size="2">FORM S-8</FONT>

<P align="center"><FONT size="2">UNDER</FONT>

<P align="center"><FONT size="2">SECURITIES ACT OF 1933</FONT>

<P align="center"><FONT size="2">DISCOVERY PARTNERS INTERNATIONAL, INC.</FONT>

<P align="center"><FONT size="2">&nbsp;
</FONT>

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<!-- link1 "EXHIBIT INDEX" -->
<DIV align="left"><A NAME="009"></A></DIV>
<P align="center"><FONT size="2">EXHIBIT INDEX</FONT>

<CENTER>
<TABLE cellspacing="0" border="0" cellpadding="0" width="100%">
<TR valign="bottom">
        <TD width="8%">&nbsp;</TD>
        <TD width="5%">&nbsp;</TD>
        <TD width="87%">&nbsp;</TD>
</TR>
<TR valign="bottom">
        <TD nowrap align="center"><FONT size="1">Exhibit Number</FONT></TD>
        <TD><FONT size="1">&nbsp;</FONT></TD>
        <TD nowrap align="left"><FONT size="1">Exhibit</FONT></TD>
</TR>
<TR valign="bottom">
        <TD nowrap align="center"><HR size="1" noshade></TD>
        <TD><FONT size="1">&nbsp;</FONT></TD>
        <TD nowrap align="center"><HR size="1" noshade></TD>
</TR>
<TR valign="bottom">
        <TD valign="top"><FONT size="2">4.1</FONT></TD>
        <TD><FONT size="2">&nbsp;</FONT></TD>
        <TD align="left" valign="top"><FONT size="2">
Instruments Defining the Rights of Stockholders. Reference is made to
Registrant&#146;s Registration Statement No.&nbsp;000-31141 on Form&nbsp;8-A, together
with the exhibits thereto, which are incorporated herein by reference
pursuant to Item&nbsp;3(c) to this Registration Statement.</FONT></TD>
</TR>

<TR valign="bottom">
        <TD valign="top"><FONT size="2">5.1</FONT></TD>
        <TD><FONT size="2">&nbsp;</FONT></TD>
        <TD align="left" valign="top"><FONT size="2">
Opinion and Consent of Brobeck, Phleger &#038; Harrison LLP.</FONT></TD>
</TR>

<TR valign="bottom">
        <TD valign="top"><FONT size="2">23.1</FONT></TD>
        <TD><FONT size="2">&nbsp;</FONT></TD>
        <TD align="left" valign="top"><FONT size="2">
Consent of Ernst &#038; Young LLP, Independent Auditors.</FONT></TD>
</TR>

<TR valign="bottom">
        <TD valign="top"><FONT size="2">23.2</FONT></TD>
        <TD><FONT size="2">&nbsp;</FONT></TD>
        <TD align="left" valign="top"><FONT size="2">
Consent of Brobeck, Phleger &#038; Harrison LLP is contained in Exhibit&nbsp;5.1.</FONT></TD>
</TR>

<TR valign="bottom">
        <TD valign="top"><FONT size="2">24.1</FONT></TD>
        <TD><FONT size="2">&nbsp;</FONT></TD>
        <TD align="left" valign="top"><FONT size="2">
Power of Attorney. Reference is made to page II-4 of this Registration Statement.</FONT></TD>
</TR>

<TR valign="bottom">
        <TD valign="top"><FONT size="2">99.1</FONT></TD>
        <TD><FONT size="2">&nbsp;</FONT></TD>
        <TD align="left" valign="top"><FONT size="2">
2000 Stock Incentive Plan</FONT></TD>
</TR>

<TR valign="bottom">
        <TD valign="top"><FONT size="2">99.2</FONT></TD>
        <TD><FONT size="2">&nbsp;</FONT></TD>
        <TD align="left" valign="top"><FONT size="2">
2000 Employee Stock Purchase Plan.</FONT></TD>
</TR>
</TABLE>
</CENTER>

<P align="center"><FONT size="2">&nbsp;</FONT>


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Discovery Partners International, Inc.
Table of Contents
As filed with the Securities and Exchange Commission on July 26, 2002
Registration No. 333-____________
SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM S-8
REGISTRATION STATEMENT
Under
The Securities Act of 1933
DISCOVERY PARTNERS INTERNATIONAL, INC.
(Exact name of registrant as specified in its charter)
Delaware
(State or other jurisdiction
of incorporation or organization)
33-0655706
(IRS Employer Identification No.)
9640 Towne Centre Drive
San Diego, California 92121
(Address of principal executive offices) (Zip Code)
DISCOVERY PARTNERS INTERNATIONAL, INC.
2000 Stock Incentive Plan
Employee Stock Purchase Plan
(Full title of the Plans)
Mr. Riccardo Pigliucci
Chief Executive Officer
DISCOVERY PARTNERS INTERNATIONAL, INC.
9640 Towne Centre Drive
San Diego, California 92121
(Name and address of agent for service)
(858) 455-8600
(Telephone number, including area code, of agent for service)
CALCULATION OF REGISTRATION FEE
Proposed
Proposed
Title of
Maximum
Maximum
Securities
Amount
Offering
Aggregate
Amount of
to be
to be
Price
Offering
Registration
Registered
Registered(1)
per Share
Price(2)
Fee
2000 Stock Incentive Plan
Common Stock, $0.001 par value
963,867 shares
$
3.62
(2)
$
3,489,198.54
(2)
$
321.01
2000 Employee Stock Purchase Plan
Common Stock, $0.001 par value
722,900 shares
$
3.62
(2)
$
2,616,898.00
(2)
$
240.75
Aggregate Registration Fee
$
561.76
(1)
This Registration Statement shall also cover any additional shares of
Registrant's Common Stock which become issuable under the Registrant's.
2000 Stock Incentive Plan and the 2000 Employee Stock Purchase Plan by
reason of any stock dividend, stock split, recapitalization or other
similar transaction effected without the Registrant's receipt of
consideration which results in an increase in the number of the
outstanding shares of Registrant's Common Stock.
(2)
Calculated solely for purposes of this offering under Rule 457(h) of the
Securities Act of 1933, as amended, on the basis of the average of the
high and low selling price per share of Registrant's Common Stock on July
24, 2002, as reported by the Nasdaq National Market.
TABLE OF CONTENTS
PART II Information Required in the Registration Statement
Item 3. Incorporation of Documents by Reference
Item 4. Description of Securities
Item 5. Interests of Named Experts and Counsel
Item 6. Indemnification of Directors and Officers
Item 7. Exemption from Registration Claimed
Item 8. Exhibits
Item 9. Undertakings
SIGNATURES
EXHIBIT INDEX
EXHIBIT 5.1
EXHIBIT 23.1
EXHIBIT 99.1
EXHIBIT 99.2
Table of Contents
PART II
Information Required in the Registration Statement
Item 3. Incorporation of Documents by Reference
Discovery Partners International, Inc. (the "Registrant") hereby
incorporates by reference into this Registration Statement the following
documents previously filed with the Securities and Exchange Commission (the
"Commission"):
(a)
The Registrant's Annual Report on Form 10-K for the fiscal
year ended December 31, 2001 filed with the Commission on March 29,
2002;
(b)
The Registrant's Quarterly Report on Form 10-Q for the fiscal
quarter ended March 31, 2001 filed with the Commission on May 13,
2002;
(c)
The Registrant's Registration Statement No. 000-31141 on Form
8-A filed with the Commission on July 25, 2000 pursuant to Section
12(g) of the Securities Exchange Act of 1934 (the "1934 Act"), in
which there is described the terms, rights, and provisions
applicable to the Registrant's outstanding Common Stock.
All reports and definitive proxy or information statements filed pursuant
to Section 13(a), 13(c), 14 or 15(d) of the 1934 Act, after the date of this
Registration Statement and prior to the filing of a post-effective amendment
which indicates that all securities offered hereby have been sold or which
de-registers all securities then remaining unsold shall be deemed to be
incorporated by reference into this Registration Statement and to be a part
hereof from the date of filing of such documents. Any statement contained in a
document incorporated or deemed to be incorporated by reference herein shall be
deemed to be modified or superseded for purposes of this Registration Statement
to the extent that a statement contained herein or in any subsequently filed
document which also is deemed to be incorporated by reference herein modifies
or supersedes such statement. Any such statement so modified or superseded
shall not be deemed, except as so modified or superseded, to constitute a part
of this Registration Statement.
Item 4. Description of Securities
Not Applicable.
Item 5. Interests of Named Experts and Counsel
Not Applicable.
Item 6. Indemnification of Directors and Officers
Section 145 of the Delaware Corporation Law provides that a Delaware
corporation may indemnify any person against expenses, judgments, fines
and settlements actually and reasonably incurred by any such person in
connection with a threatened, pending or completed action, suit or
proceeding in which such person is involved by reason of the fact that
such person is or was a director, officer, employee or agent of such
corporation, provided that (i) such person acted in good faith and in a
manner reasonably believed to be in or not opposed to the best interests
of the corporation and (ii) with respect to any criminal action or
proceeding, such person had no reasonable cause to believe such person's
conduct was unlawful. If the action or suit is by or in the name of the
corporation, the corporation may indemnify any such person against
expenses actually and reasonably incurred by such person in connection
with the defense or settlement of such action or suit if such person
acted in good faith and in a manner such person reasonably believed to be
in or not opposed to the best interests of the corporation, except that
no indemnification may be made in respect to any claim, issue or matter
as to which such person shall have been adjudged to be liable to the
corporation for negligence or misconduct in the performance of such
person's duty to the
II-1
Table of Contents
corporation, unless and only to the extent that the Delaware Court of
Chancery or the court in which the action or suit is brought determines
upon application that, despite the adjudication of liability but in view
of all of the circumstances of the case, such person is fairly and
reasonably entitled to indemnity for such expenses as the court deems
proper.
The Registrant's certificate of incorporation limits the liability of
directors to the maximum extent permitted by Delaware law.
The Registrant's certificate of incorporation and bylaws provide that the
Registrant shall indemnify its directors and executive officers and may
indemnify its other officers and employees and other agents to the
fullest extent permitted by law. The Registrant believes that
indemnification under its bylaws covers at least negligence and gross
negligence on the part of the indemnified parties. The Registrant's
bylaws also permit it to secure insurance on behalf of any officer,
director, employee or other agent for any liability arising out of his or
her actions in such capacity, regardless of whether the bylaws would
permit indemnification.
In addition to indemnification provided for in its certificate of
incorporation and bylaws, the Registrant has entered into agreements to
indemnify its directors and executive officers. The agreements, among
other things, provide for indemnification of the Registrant's directors
and executive officers for expenses specified in the agreements,
including attorneys' fees, judgments, fines and settlement amounts
incurred by the Registrant's directors or executive officers in any
action or proceeding arising out of that person's services as a director
or executive officer of the Registrant, any subsidiary of the Registrant
or any other entity to which the person provides services at the
Registrant's request. In addition, the Registrant maintains directors'
and officers' insurance. The Registrant believes that all of the
foregoing provisions and agreements are necessary to attract and retain
qualified persons as directors and executive officers.
Item 7. Exemption from Registration Claimed
Not Applicable.
Item 8. Exhibits
Exhibit Number
Exhibit
4.1
Instruments Defining the Rights of Stockholders. Reference is made to
Registrant's Registration Statement No. 000-31141 on Form 8-A, together
with the exhibits thereto, which are incorporated herein by reference
pursuant to Item 3(c) to this Registration Statement.
5.1
Opinion and Consent of Brobeck, Phleger & Harrison LLP.
23.1
Consent of Ernst & Young, LLP, Independent Auditors.
23.2
Consent of Brobeck, Phleger & Harrison LLP is contained in Exhibit 5.1
24.1
Power of Attorney. Reference is made to page II-4 of this Registration Statement.
99.1
2000 Stock Incentive Plan
99.2
2000 Employee Stock Purchase Plan.
Item 9. Undertakings
A. The undersigned Registrant hereby undertakes: (1) to file, during any
period in which offers or sales are being made, a post-effective amendment to
this Registration Statement: (i) to include any prospectus required by Section
10(a)(3) of the 1933 Act; (ii) to reflect in the prospectus any facts or events
arising after the effective date of this Registration Statement (or the most
recent post-effective amendment thereof) which, individually or in the
aggregate, represent a fundamental change in the information set forth in this
Registration Statement; and (iii) to include any material information with
respect to the plan of distribution not previously disclosed in this
Registration Statement or any material change to such information in this
Registration Statement; provided, however, that clauses (1)(i) and (1)(ii)
shall not apply if the information required to be included in a post-effective
amendment by those clauses is contained in periodic reports filed by the
Registrant pursuant to Section 13 or Section 15(d) of the 1934 Act that are
incorporated by reference into this Registration Statement; (2) that for the
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purpose of determining any liability under the 1933 Act each such
post-effective amendment shall be deemed to be a new registration statement
relating to the securities offered therein and the offering of such securities
at that time shall be deemed to be the initial bona fide offering thereof; and
(3) to remove from registration by means of a post-effective amendment any of
the securities being registered which remain unsold at the termination of the
Registrant's 2000 Stock Incentive Plan or Employee Stock Purchase Plan.
B. The undersigned Registrant hereby undertakes that, for purposes of
determining any liability under the 1933 Act, each filing of the Registrant's
annual report pursuant to Section 13(a) or Section 15(d) of the 1934 Act that
is incorporated by reference into this Registration Statement shall be deemed
to be a new registration statement relating to the securities offered therein,
and the offering of such securities at that time shall be deemed to be the
initial bona fide offering thereof.
C. Insofar as indemnification for liabilities arising under the 1933 Act
may be permitted to directors, officers or controlling persons of the
Registrant pursuant to the indemnification provisions summarized in Item 6 or
otherwise, the Registrant has been advised that, in the opinion of the
Commission, such indemnification is against public policy as expressed in the
1933 Act and is, therefore, unenforceable. In the event that a claim for
indemnification against such liabilities (other than the payment by the
Registrant of expenses incurred or paid by a director, officer, or controlling
person of the Registrant in the successful defense of any action, suit or
proceeding) is asserted by such director, officer or controlling person in
connection with the securities being registered, the Registrant will, unless in
the opinion of its counsel the matter has been settled by controlling
precedent, submit to a court of appropriate jurisdiction the question whether
such indemnification by it is against public policy as expressed in the 1933
Act and will be governed by the final adjudication of such issue.
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SIGNATURES
Pursuant to the requirements of the Securities Act of 1933, as amended,
the Registrant certifies that it has reasonable grounds to believe that it
meets all of the requirements for filing on Form S-8, and has duly caused this
Registration Statement to be signed on its behalf by the undersigned, thereunto
duly authorized, in the City of San Diego, State of California, on this 26th
day of July, 2002.
DISCOVERY PARTNERS INTERNATIONAL, INC
By:
/s/ Riccardo Pigliucci
Riccardo Pigliucci
Chief Executive Officer
POWER OF ATTORNEY
KNOW ALL PERSONS BY THESE PRESENTS:
That each person whose signature appears below constitutes and appoints
Riccardo Pigliucci, Chief Executive Officer, and Chairman of the Board, and
Craig S. Kussman, Chief Financial Officer, Vice President Finance and
Administration, and Secretary, and each of them, as such person's true and
lawful attorneys-in-fact and agents, with full power of substitution and
resubstitution, for such person and in such person's name, place and stead, in
any and all capacities, to sign any and all amendments (including
post-effective amendments) to this Registration Statement, and to file same,
with all exhibits thereto, and other documents in connection therewith, with
the Securities and Exchange Commission, granting unto said attorneys-in-fact
and agents, and each of them, full power and authority to do and perform each
and every act and thing requisite and necessary to be done in connection
therewith, as fully to all intents and purposes as such person might or could
do in person, hereby ratifying and confirming all that said attorneys-in-fact
and agents, or any of them, or their or his or her substitutes, may lawfully do
or cause to be done by virtue thereof. This Power of Attorney may be signed in
several counterparts.
Pursuant to the requirements of the Securities Act of 1933, as amended,
this Registration Statement has been signed below by the following persons on
behalf of the Registrant and in the capacities and on the dates indicated:
Signature
Title
Date
/s/ Riccardo Pigliucci
Riccardo Pigliucci
Chief Executive Officer and
Chairman of
the Board of
Directors (principal
executive officer)
July 26, 2002
/s/ Craig S. Kussman
Craig S. Kussman
Chief Financial Officer, Vice
President
Finance and
Administration and Secretary
(principal financial and
accounting officer)
July 26, 2002
/s/ Harry F. Hixson, Jr., Ph.D.
Harry F. Hixson, Jr., Ph.D.
Director
July 26, 2002
/s/ Dieter Hoehn
Dieter Hoehn
Director
July 26, 2002
/s/ Sir Colin Dollery
Sir Colin Dollery
Director
July 26, 2002
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Signature
Title
Date
/s/ John P. Walker
John P. Walker
Director
July 26, 2002
/s/ Alan J. Lewis, Ph.D.
Alan J. Lewis, Ph.D.
Director
July 26, 2002
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SECURITIES AND EXCHANGE COMMISSION
WASHINGTON, D.C. 20549
EXHIBITS
TO
FORM S-8
UNDER
SECURITIES ACT OF 1933
DISCOVERY PARTNERS INTERNATIONAL, INC.
Table of Contents
EXHIBIT INDEX
Exhibit Number
Exhibit
4.1
Instruments Defining the Rights of Stockholders. Reference is made to
Registrant's Registration Statement No. 000-31141 on Form 8-A, together
with the exhibits thereto, which are incorporated herein by reference
pursuant to Item 3(c) to this Registration Statement.
5.1
Opinion and Consent of Brobeck, Phleger & Harrison LLP.
23.1
Consent of Ernst & Young LLP, Independent Auditors.
23.2
Consent of Brobeck, Phleger & Harrison LLP is contained in Exhibit 5.1.
24.1
Power of Attorney. Reference is made to page II-4 of this Registration Statement.
99.1
2000 Stock Incentive Plan
99.2
2000 Employee Stock Purchase Plan.