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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-align: center">As filed with the Securities and Exchange
Commission on August 10, 2018</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-align: right">Registration No. 333-</P>

<P STYLE="font: bold 14pt Times New Roman, Times, Serif; margin: 0; text-transform: uppercase; text-align: center">UNITED STATES<BR>
SECURITIES AND EXCHANGE COMMISSION</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-align: center">Washington, D.C. 20549</P>

<HR SIZE="1" NOSHADE ALIGN="CENTER" STYLE="width: 50%; color: black">

<P STYLE="font: bold 16pt Times New Roman, Times, Serif; margin: 0; text-align: center">FORM S-8</P>

<P STYLE="font: bold 14pt Times New Roman, Times, Serif; margin: 0; text-transform: uppercase; text-align: center">REGISTRATION
STATEMENT<BR>
UNDER<BR>
THE SECURITIES ACT OF 1933</P>

<HR SIZE="1" NOSHADE ALIGN="CENTER" STYLE="width: 50%; color: black">

<P STYLE="font: bold 22pt Times New Roman, Times, Serif; margin: 0 0 1pt; text-align: center">ENZO BIOCHEM, INC.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-align: center"><I>(Exact name of Registrant as specified
in its charter)</I></P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="width: 100%; border-collapse: collapse">
<TR STYLE="vertical-align: top">
    <TD COLSPAN="3" STYLE="padding-right: 5.4pt; padding-left: 5.4pt">
        <P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0; text-align: center">New York</P>
        <P STYLE="font: italic 10pt Times New Roman, Times, Serif; margin: 0; text-align: center">(State or Other Jurisdiction<BR>
        of Incorporation or Organization)</P></TD>
    <TD COLSPAN="4" STYLE="font: 10pt Times New Roman, Times, Serif; padding-right: 5.4pt; padding-bottom: 6pt; padding-left: 5.4pt; text-align: center">&nbsp;</TD>
    <TD STYLE="padding-right: 5.4pt; padding-left: 5.4pt">
        <P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0; text-align: center">13-2866202</P>
        <P STYLE="font: italic 10pt Times New Roman, Times, Serif; margin: 0; text-align: center">(I.R.S. Employer Identification Number)</P></TD></TR>
<TR STYLE="vertical-align: top">
    <TD COLSPAN="3" STYLE="font: bold 10pt Times New Roman, Times, Serif; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center">&nbsp;</TD>
    <TD COLSPAN="4" STYLE="font: 10pt Times New Roman, Times, Serif; padding-right: 5.4pt; padding-bottom: 6pt; padding-left: 5.4pt; text-align: center">&nbsp;</TD>
    <TD STYLE="font: bold 10pt Times New Roman, Times, Serif; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD COLSPAN="3" STYLE="padding-right: 5.4pt; padding-left: 5.4pt">
        <P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0; text-align: center">527 Madison Avenue</P>
        <P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0; text-align: center">New York, NY</P>
        <P STYLE="font: italic 10pt Times New Roman, Times, Serif; margin: 0; text-align: center">(Address of Principal Executive Offices)</P></TD>
    <TD COLSPAN="4" STYLE="font: 10pt Times New Roman, Times, Serif; padding-right: 5.4pt; padding-bottom: 6pt; padding-left: 5.4pt; text-align: center">&nbsp;</TD>
    <TD STYLE="padding-right: 5.4pt; padding-left: 5.4pt">
        <P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0; text-align: center">10022</P>
        <P STYLE="font: italic 10pt Times New Roman, Times, Serif; margin: 0; text-align: center">(Zip Code)</P></TD></TR>
<TR STYLE="vertical-align: top">
    <TD COLSPAN="3" STYLE="font: bold 10pt Times New Roman, Times, Serif; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center">&nbsp;</TD>
    <TD COLSPAN="4" STYLE="font: 10pt Times New Roman, Times, Serif; padding-right: 5.4pt; padding-bottom: 6pt; padding-left: 5.4pt; text-align: center">&nbsp;</TD>
    <TD STYLE="font: bold 10pt Times New Roman, Times, Serif; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD COLSPAN="8" STYLE="font: bold 10pt Times New Roman, Times, Serif; padding-right: 5.4pt; padding-left: 0.5in; text-align: center; text-indent: -0.5in">ENZO BIOCHEM, INC. AMENDED AND RESTATED 2011 INCENTIVE PLAN</TD></TR>
<TR STYLE="vertical-align: top">
    <TD COLSPAN="8" STYLE="font: italic 10pt Times New Roman, Times, Serif; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center">(Full title of the plan)</TD></TR>
<TR STYLE="vertical-align: top">
    <TD COLSPAN="8" STYLE="font: italic 10pt Times New Roman, Times, Serif; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD COLSPAN="2" STYLE="font: 10pt Times New Roman, Times, Serif; padding-right: 5.4pt; padding-bottom: 6pt; padding-left: 5.4pt; text-align: center">&nbsp;</TD>
    <TD COLSPAN="3" STYLE="padding-right: 5.4pt; padding-left: 5.4pt">
        <P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0; text-align: center">Barry W. Weiner</P>
        <P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0; text-align: center">President, Chief Financial Officer, Principal
        Accounting Officer, Treasurer and Director Enzo Biochem, Inc.</P>
        <P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0; text-align: center">527 Madison Avenue</P>
        <P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0; text-align: center">New York, NY 10022</P>
        <P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0; text-align: center">(212) 583-0100</P></TD>
    <TD COLSPAN="3" STYLE="font: 10pt Times New Roman, Times, Serif; padding-right: 5.4pt; padding-bottom: 6pt; padding-left: 5.4pt; text-align: center">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD COLSPAN="8" STYLE="font: italic 10pt Times New Roman, Times, Serif; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center">(Name and Address of Agent For Service)</TD></TR>
<TR STYLE="vertical-align: top">
    <TD COLSPAN="2" STYLE="font: 10pt Times New Roman, Times, Serif; padding-right: 5.4pt; padding-bottom: 6pt; padding-left: 5.4pt; text-align: center">&nbsp;</TD>
    <TD COLSPAN="3" STYLE="padding-right: 5.4pt; padding-left: 5.4pt">
        <P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0; text-align: center">&nbsp;</P>
        <P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0; text-align: center">Copy to:</P>
        <P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0; text-align: center">Robert H. Cohen, Esq.</P>
        <P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0; text-align: center">McDermott Will &amp; Emery LLP</P>
        <P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0; text-align: center">340 Madison Avenue</P>
        <P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0; text-align: center">New York, NY 10173</P>
        <P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0; text-align: center">(212) 547-5400</P></TD>
    <TD COLSPAN="3" STYLE="font: 10pt Times New Roman, Times, Serif; padding-right: 5.4pt; padding-bottom: 6pt; padding-left: 5.4pt; text-align: center">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD COLSPAN="2" STYLE="font: 10pt Times New Roman, Times, Serif; padding-right: 5.4pt; padding-bottom: 6pt; padding-left: 5.4pt; text-align: center">&nbsp;</TD>
    <TD COLSPAN="3" STYLE="font: bold 10pt Times New Roman, Times, Serif; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center">&nbsp;</TD>
    <TD COLSPAN="3" STYLE="font: 10pt Times New Roman, Times, Serif; padding-right: 5.4pt; padding-bottom: 6pt; padding-left: 5.4pt; text-align: center">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD COLSPAN="8" STYLE="font: 10pt Times New Roman, Times, Serif; padding-right: 5.4pt; padding-bottom: 6pt; padding-left: 5.4pt; text-align: left">Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, or a smaller reporting company. See the definitions of &ldquo;large accelerated filer,&rdquo; &ldquo;accelerated filer&rdquo; and &ldquo;smaller reporting company&rdquo; in Rule 12b-2 of the Exchange Act. (Check one):</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; padding: 3pt 5.4pt">Large accelerated filer <FONT STYLE="font-family: Wingdings">&#168;</FONT></TD>
    <TD COLSPAN="3" STYLE="font: 10pt Times New Roman, Times, Serif; padding: 3pt 5.4pt">Accelerated filer <FONT STYLE="font-family: Wingdings">&#254;</FONT></TD>
    <TD COLSPAN="2" STYLE="font: 10pt Times New Roman, Times, Serif; padding: 3pt 5.4pt">Non-accelerated filer <FONT STYLE="font-family: Wingdings">&#168;</FONT><BR>
(Do not check if a smaller <BR>
Reporting company)</TD>
    <TD COLSPAN="2" STYLE="font: 10pt Times New Roman, Times, Serif; padding: 3pt 5.4pt">Smaller reporting company&nbsp;&nbsp;&nbsp;<FONT STYLE="font-family: Wingdings">&#168;</FONT></TD></TR>
<TR>
    <TD STYLE="width: 25%">&nbsp;</TD>
    <TD STYLE="width: 8%">&nbsp;</TD>
    <TD STYLE="width: 6%">&nbsp;</TD>
    <TD STYLE="width: 6%">&nbsp;</TD>
    <TD STYLE="width: 20%">&nbsp;</TD>
    <TD STYLE="width: 4%">&nbsp;</TD>
    <TD STYLE="width: 3%">&nbsp;</TD>
    <TD STYLE="width: 28%">&nbsp;</TD></TR>
</TABLE>


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<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 12pt 0; text-align: center">CALCULATION OF REGISTRATION FEE</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="width: 100%">
<TR STYLE="vertical-align: top">
    <TD COLSPAN="2">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD COLSPAN="2" STYLE="font: 10pt Times New Roman, Times, Serif; padding-bottom: 6pt; text-align: center">Title of securities <BR>
to be Registered</TD>
    <TD>&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; padding-bottom: 6pt; text-align: center">Amount to be<BR>
registered(1)(2)</TD>
    <TD>&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; padding-bottom: 6pt; text-align: center">Proposed maximum <BR>
offering price per share(3)</TD>
    <TD>&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; padding-bottom: 6pt; text-align: center">Proposed maximum <BR>
aggregate offering price(3)</TD>
    <TD>&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; padding-bottom: 6pt; text-align: center">Amount of<BR>
registration fee</TD></TR>
<TR STYLE="vertical-align: top">
    <TD COLSPAN="2" STYLE="text-align: center">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD STYLE="text-align: center">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD STYLE="text-align: center">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD STYLE="text-align: center">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD STYLE="text-align: center">&nbsp;</TD></TR>
<TR STYLE="background-color: rgb(229,255,255)">

    <TD COLSPAN="2" STYLE="vertical-align: top; font: 10pt Times New Roman, Times, Serif; padding-top: 3pt; padding-bottom: 3pt">Common Stock, <BR>
par value $0.01 per share</TD>
    <TD STYLE="vertical-align: top">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; font: 10pt Times New Roman, Times, Serif; padding-top: 3pt; padding-bottom: 3pt">2,000,000(4)</TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; font: 10pt Times New Roman, Times, Serif; padding-top: 3pt; padding-bottom: 3pt">$4.41</TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; font: 10pt Times New Roman, Times, Serif; padding-top: 3pt; padding-bottom: 3pt">$8,820,000</TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; font: 10pt Times New Roman, Times, Serif; padding-top: 3pt; padding-bottom: 3pt">$1,098.09</TD></TR>
<TR>
    <TD COLSPAN="2" STYLE="vertical-align: top; font: 10pt Times New Roman, Times, Serif; padding-top: 3pt; padding-bottom: 3pt">&nbsp;</TD>
    <TD STYLE="vertical-align: top; font: 10pt Times New Roman, Times, Serif; padding-top: 3pt; padding-bottom: 3pt">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; font: 10pt Times New Roman, Times, Serif; padding-top: 3pt; padding-bottom: 3pt">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; font: 10pt Times New Roman, Times, Serif; padding-top: 3pt; padding-bottom: 3pt">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; font: 10pt Times New Roman, Times, Serif; padding-top: 3pt; padding-bottom: 3pt">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; font: 10pt Times New Roman, Times, Serif; padding-top: 3pt; padding-bottom: 3pt">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; font: 10pt Times New Roman, Times, Serif; padding-top: 3pt; padding-bottom: 3pt">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; font: 10pt Times New Roman, Times, Serif; padding-top: 3pt; padding-bottom: 3pt">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; font: 10pt Times New Roman, Times, Serif; padding-top: 3pt; padding-bottom: 3pt">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; padding: 3pt 5.4pt">(1)</TD>
    <TD COLSPAN="9" STYLE="font: 10pt Times New Roman, Times, Serif; padding: 3pt 5.4pt">Pursuant to Rule 416(a) of the Securities Act of 1933, as amended (the &ldquo;Securities Act&rdquo;), this Registration Statement also registers any additional shares of Common Stock, par value $0.01 per share (&ldquo;Common Stock&rdquo;) of Enzo Biochem, Inc. (the &ldquo;Company&rdquo;), as may become available or issuable under the Enzo Biochem, Inc. Amended And Restated 2011 Incentive Plan (the &ldquo;Plan&rdquo;), to prevent dilution resulting from stock splits, stock dividends, or similar transactions.</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; padding: 3pt 5.4pt">(2)</TD>
    <TD COLSPAN="9" STYLE="font: 10pt Times New Roman, Times, Serif; padding: 3pt 5.4pt">Pursuant to Rule 416(c) under the Securities Act, this Registration Statement also covers an indeterminate amount of interests to be offered or sold pursuant to the Plan.</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; padding: 3pt 5.4pt">(3)</TD>
    <TD COLSPAN="9" STYLE="font: 10pt Times New Roman, Times, Serif; padding: 3pt 5.4pt">Estimated solely for the purpose of determining the amount of the registration fee pursuant to Rule 457(c) and Rule 457(h) under the Securities Act, based on the average of the high and low prices per share of Common Stock as reported on the New York Stock Exchange on August 2, 2018.</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; padding: 3pt 5.4pt">(4)</TD>
    <TD COLSPAN="9" STYLE="font: 10pt Times New Roman, Times, Serif; padding: 3pt 5.4pt">Represents the additional shares of Common Stock  subject to future grants under the Plan.</TD></TR>
<TR>
    <TD STYLE="width: 5%">&nbsp;</TD>
    <TD STYLE="width: 25%">&nbsp;</TD>
    <TD STYLE="width: 1%">&nbsp;</TD>
    <TD STYLE="width: 15%">&nbsp;</TD>
    <TD STYLE="width: 1%">&nbsp;</TD>
    <TD STYLE="width: 17%">&nbsp;</TD>
    <TD STYLE="width: 1%">&nbsp;</TD>
    <TD STYLE="width: 17%">&nbsp;</TD>
    <TD STYLE="width: 1%">&nbsp;</TD>
    <TD STYLE="width: 17%">&nbsp;</TD></TR>
</TABLE>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-align: center"><U>Explanatory Note</U></P>

<P STYLE="margin: 0">This Registration Statement is filed solely to reflect an increase of 2,000,000 shares of the Registrant&rsquo;s
Common Stock reserved for the Plan. The securities subject to this Registration Statement are of the same class for which the Registrant previously
filed a Registration Statement on Form S-8 under the Securities Act. Accordingly, the contents of the Registrant&rsquo;s Registration
Statement on Form S-8, File No. 333-172127, as filed with the Securities and Exchange Commission (the &ldquo;Commission&rdquo;)
on February 9, 2011, are hereby incorporated by reference pursuant to General Instruction E to Form S-8, except for item 6 which
is being updated by this Registration Statement.</P>



<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-indent: 0.5in"></P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-align: center">PART II<BR>
INFORMATION REQUIRED IN THE REGISTRATION STATEMENT</P>


<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0 0 12pt">ITEM 3. INCORPORATION OF DOCUMENTS BY REFERENCE.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-indent: 0.5in">The following documents filed with the
Commission are hereby incorporated by reference into this Registration Statement on Form S-8:</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 12pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 1.8pt"></TD><TD STYLE="width: 17.1pt">(a)</TD><TD>the Company&rsquo;s Annual Report on Form 10-K for the year ended July 31, 2017, filed with the Commission on September 27,
2017;</TD></TR></TABLE>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 12pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 1.8pt"></TD><TD STYLE="width: 17.1pt">(b)</TD><TD>the Company&rsquo;s Quarterly Reports on Form 10-Q for the quarter ended October 31, 2017 filed with the Commission on December
7, 2017, for the quarter ended January 31, 2018 filed with the Commission on March 12, 2018, and for the quarter ended April 30,
2018 filed with the Commission on June 11, 2018;</TD></TR></TABLE>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 12pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 1.8pt"></TD><TD STYLE="width: 17.1pt">(c)</TD><TD>the Company&rsquo;s Current Reports on Form 8-K filed with the Commission on October 23, 2017, January 22, 2018, April 24,
2018 and July 18, 2018; and</TD></TR></TABLE>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 12pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 1.8pt"></TD><TD STYLE="width: 17.1pt">(d)</TD><TD>the description of the Common Stock set forth in the Company&rsquo;s registration statement on Form 8-A, filed with the Commission
on December 8, 1999.</TD></TR></TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-indent: 0.5in">All documents filed by the Company pursuant
to Section&nbsp;13(a), 13(c), 14 or 15(d) of the Securities Exchange Act of 1934, as amended, subsequent to the date hereof and
prior to the filing of a post-effective</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; text-align: center">2</p>


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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-indent: 0.0in">amendment which indicates that all securities offered have been sold or which deregisters
all securities then remaining unsold shall be deemed to be incorporated by reference herein and to be a part hereof from the date
of filing of such documents. Notwithstanding the foregoing, unless specifically stated to the contrary, none of the information
disclosed by the Company under Items 2.02 or 7.01 of any Current Report on Form 8-K that the Company may from time to time furnish
to the Commission will be incorporated by reference into, or otherwise included in, this Registration Statement. Any statement
contained herein or in a document incorporated or deemed to be incorporated by reference herein shall be deemed to be modified
or superseded for purposes of this Registration Statement to the extent that a statement contained herein or in any subsequently
filed document which also is or is deemed to be incorporated by reference herein modifies or supersedes such statement. Any such
statement so modified or superseded shall not be deemed, except as so modified or superseded, to constitute a part of this Registration
Statement.</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0 0 10pt">ITEM 4. DESCRIPTION OF SECURITIES.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-indent: 0.5in">Not applicable.</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0 0 10pt">ITEM 5. INTERESTS OF NAMED EXPERTS AND COUNSEL.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-indent: 0.5in">Not applicable.</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0 0 12pt">ITEM 6. INDEMNIFICATION OF DIRECTORS AND OFFICERS.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-indent: 0.5in">The Company is a New York corporation.
Sections 721 through 726 of the New York Business Corporation Law (the &ldquo;BCL&rdquo;) provide that, in certain circumstances,
a corporation may indemnify its directors and officers against judgments, fines, amounts paid in settlement and reasonable expenses,
including attorneys&rsquo; fees, actually and necessarily incurred as a result of any actual or threatened action or proceeding
against such directors or officers, or by or in the right of any other enterprise which such directors or officers served in any
capacity at the request of the corporation, by reason of the fact that such person acted in any of the capacities set forth above,
if such director or officer (i) acted, in good faith, for a purpose which he or she reasonably believed to be in or not opposed
to the best interests of the corporation and (ii) in criminal actions or proceedings, had no reasonable cause to believe that his
or her conduct was unlawful; provided, however, that no indemnification may be provided where a final adjudication adverse to the
director or officer establishes that his or her actions were committed in bad faith or were the result of active and deliberate
dishonesty and were material to the cause of action adjudicated, or that he or she personally gained a financial profit or other
advantage to which he or she was not legally entitled. A corporation is required to indemnify against reasonable expenses (including
attorneys&rsquo; fees) incurred by any director or officer who successfully defends any such action. The BCL also provides for
indemnification of officers and directors in actions by or in the right of the corporation, subject to certain exceptions. Indemnification
provided by these provisions of the BCL is not exclusive of any other rights to which a director or officer may be entitled. The
foregoing statements are subject to the detailed provisions of the BCL.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-indent: 0.5in">The Company&rsquo;s Certificate of Incorporation,
as amended, states the following:</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-indent: 0.5in">&ldquo;Article 8. The Corporation shall,
to the fullest extent permitted by the Business Corporation Law of the States of New York, indemnify any and all persons whom it
shall have power to indemnify from and against any and all of the expenses, liabilities or other matters as provided under Articles
of Seven of the Business Corporation Law of the State of New York.&rdquo;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-indent: 0.5in">&ldquo;Article 12. No director of the
Corporation shall be liable to the Corporation or its shareholders for damage for any breach of duty in such capacity, provided
that nothing contained in this Article shall eliminate or limit the liability of a director (i) if a judgment or other final adjudication
adverse to him establishes that his acts or omissions were in bad faith or involved acts or omissions were in bad faith or involved
intentional misconduct or a knowing violation of law or that he personally gained in fact a financial profit or other advantage
to which he was not legally entitled or that his acts violated Section 719 of the New York Business Corporation Law or (ii) for
any act or omission prior to July 8, 1988.&rdquo;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-indent: 0.5in">ARTICLE V of the Company&rsquo;s By-Laws
provides as follows:</P>


<P STYLE="font: 10pt Times New Roman, Times, Serif; text-align: center">3</p>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-indent: 0.5in">&ldquo;The Corporation shall, to the
fullest extent permitted by the laws of the State of incorporation, indemnify any and all persons whom it shall have power to indemnify
against any and all of the costs, expenses, liabilities or other matters incurred by them by reason of having been officers or
directors of the Corporation, any subsidiary of the Corporation or of any other corporation for which he acted as officer or director
at the request of the Corporation.&rdquo;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-indent: 0.5in">The Company has also obtained directors&rsquo;
and officers&rsquo; liability insurance, which insures against liabilities that the Company&rsquo;s directors or officers may incur
in such capabilities.</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0 0 12pt">ITEM 7. EXEMPTION FROM REGISTRATION CLAIMED.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-indent: 0.5in">Not applicable.</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0 0 12pt">ITEM 8. EXHIBITS</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0 0 12pt">See attached Exhibit Index.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 12pt 0"><B>ITEM 9. UNDERTAKINGS.</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-indent: 0.5in">(a) &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;The
Company hereby undertakes:</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0 0 12pt 0.5in; text-indent: 0.5in">(1) To file, during any period
in which offers or sales are being made, a post-effective amendment to this Registration Statement:</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 12pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 1in"></TD><TD STYLE="width: 0.25in">(i)</TD><TD>to include any prospectus required by Section 10(a)(3) of the Securities Act;</TD></TR></TABLE>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 12pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 1in"></TD><TD STYLE="width: 0.25in">(ii)</TD><TD>to reflect in the prospectus any facts or events arising after the effective date of this Registration Statement (or the most
recent post-effective amendment thereof) which, individually or in the aggregate, represent a fundamental change in the information
set forth in this Registration Statement;</TD></TR></TABLE>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 12pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 1in"></TD><TD STYLE="width: 0.25in">(iii)</TD><TD>to include any material information with respect to the plan of distribution not previously disclosed in this Registration
Statement or any material change to such information in this Registration Statement;</TD></TR></TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-indent: 0.5in"><I>Provided, however</I>, that paragraphs
(a)(1)(i) and (a)(1)(ii) do not apply if the registration statement is on Form S-8, and the information required to be included
in a post-effective amendment by those paragraphs is contained in reports filed with or furnished to the Commission by the Company
pursuant to Section 13 or Section 15(d) of the Exchange Act that are incorporated by reference in this Registration Statement.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0 0 12pt 0.5in; text-indent: 0.5in">(2) That, for the purpose of determining
any liability under the Securities Act, each such post-effective amendment shall be deemed to be a new registration statement relating
to the securities offered therein, and the offering of such securities at that time shall be deemed to be the initial <I>bona fide</I>
offering thereof.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0 0 12pt 0.5in; text-indent: 0.5in">(3) To remove from registration
by means of a post-effective amendment any of the securities being registered which remain unsold at the termination of the offering.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-indent: 0.5in">(b) The Company hereby undertakes that,
for purposes of determining any liability under the Securities Act, each filing of the Company&rsquo;s annual report pursuant to
Section 13(a) or Section 15(d) of the Exchange Act (and, where applicable, each filing of an employee benefit plan&rsquo;s annual
report pursuant to Section 15(d) of the Exchange Act) that is incorporated by reference in this Registration Statement will be
deemed to be a new registration statement relating to the securities offered therein, and the offering of such securities at that
time shall be deemed to be the initial <I>bona fide</I> offering thereof.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-indent: 0.5in">(c) Insofar as indemnification for liabilities
arising under the Securities Act of may be permitted to directors, officers and controlling persons of the Company pursuant to
the foregoing provisions, or otherwise, the
</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; text-align: center">4</p>




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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-indent: 0.0in">Company has been advised that in the opinion of the Commission such indemnification
is against public policy as expressed in the Securities Act and is, therefore, unenforceable. In the event that a claim for indemnification
against such liabilities (other than the payment by the Company of expenses incurred or paid by a director, officer or controlling
person of the Company in the successful defense of any action, suit or proceeding) is asserted by such director, officer or controlling
person in connection with the securities being registered, the Company will, unless in the opinion of its counsel the matter has
been settled by controlling precedent, submit to a court of appropriate jurisdiction the question whether such indemnification
by it is against public policy as expressed in the Securities Act and will be governed by the final adjudication of such issue.
</P>


<P STYLE="font: 10pt Times New Roman, Times, Serif; text-align: center">5</p>

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<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-align: center">SIGNATURES</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-indent: 0.5in">Pursuant to the requirements of the Securities
Act of 1933, the Company certifies that it has reasonable grounds to believe that it meets all of the requirements for filing on
Form S-8 and has duly caused this registration statement to be signed on its behalf by the undersigned, thereunto duly authorized,
in the City of New York, State of New York, on August 10, 2018.</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="width: 100%">
<TR STYLE="vertical-align: top">
    <TD ROWSPAN="8" STYLE="width: 51%">&nbsp;</TD>
    <TD STYLE="width: 3%">&nbsp;</TD>
    <TD STYLE="width: 46%">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD COLSPAN="2" STYLE="padding-top: 3pt; padding-bottom: 3pt; font: 10pt Times New Roman, Times, Serif">ENZO BIOCHEM, INC.</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-top: 3pt; padding-bottom: 3pt; font: 10pt Times New Roman, Times, Serif">By:</TD>
    <TD STYLE="padding-top: 3pt; padding-bottom: 3pt; font: 10pt Times New Roman, Times, Serif">/s/ Elazar Rabbani, Ph.D.</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD STYLE="text-align: center; border-bottom: rgb(153,153,153) 1px solid">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD ROWSPAN="3">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">Elazar Rabbani, Ph.D.</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">Chairman of the Board, Chief Executive Officer and Director (Principal
        Executive Officer)</P></TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-top: 3pt; padding-bottom: 3pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</TD>
    <TD STYLE="padding-top: 3pt; padding-bottom: 3pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</TD>
    <TD STYLE="padding-top: 3pt; padding-bottom: 3pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</TD></TR>
</TABLE>
<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-align: center"><A NAME="x1__power"></A>POWER OF ATTORNEY</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-indent: 0.5in">KNOW ALL PERSONS BY THESE PRESENT, that
each person whose signature appears below constitutes and appoints Elazar Rabbani and Barry W. Weiner, and each or either of them,
his true and lawful attorney-in-fact and agent, with full power of substitution and resubstitution, for him and in his name, place
and stead, in any and all capacities, to sign any and all amendments, including post-effective amendments, to this Form S-8 Registration
Statement, and to file the same, with all exhibits thereto, and other documents in connection therewith, with the Securities and
Exchange Commission, granting unto said attorneys-in-fact and agents, and each of them, full power and authority to do and perform
each and every act and thing requisite and necessary to be done in connection therewith, as fully to all intents and purposes as
he might or could do in person, hereby ratifying and confirming all that said attorneys-in-fact and agents, or any of them, or
their or his substitutes or substitute, may lawfully do or cause to be done by virtue hereof.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-indent: 0.5in">Pursuant to the requirements of the Securities
Act of 1933, this Registration Statement has been signed below by the following persons in the capacities and on the dates indicated.</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="width: 100%; border-collapse: collapse">
<TR STYLE="vertical-align: top">
    <TD STYLE="width: 27%; padding-right: 5.4pt; padding-left: 5.4pt">&nbsp;</TD>
    <TD STYLE="width: 5%; padding-right: 5.4pt; padding-left: 5.4pt">&nbsp;</TD>
    <TD STYLE="width: 68%; padding-right: 5.4pt; padding-left: 5.4pt">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; padding-right: 5.4pt; padding-left: 5.4pt">Date: August 10, 2018</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; padding-right: 5.4pt; padding-left: 5.4pt">By:</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; padding-right: 5.4pt; padding-left: 5.4pt">/s/ Elazar Rabbani, Ph.D.</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-right: 5.4pt; padding-left: 5.4pt">&nbsp;</TD>
    <TD STYLE="padding-right: 5.4pt; padding-left: 5.4pt">&nbsp;</TD>
    <TD STYLE="padding-right: 5.4pt; padding-left: 5.4pt; border-bottom: rgb(153,153,153) 1px solid">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-right: 5.4pt; padding-left: 5.4pt">&nbsp;</TD>
    <TD STYLE="padding-right: 5.4pt; padding-left: 5.4pt">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; padding-right: 5.4pt; padding-left: 5.4pt">Elazar Rabbani, Ph.D.</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-right: 5.4pt; padding-left: 5.4pt">&nbsp;</TD>
    <TD STYLE="padding-right: 5.4pt; padding-left: 5.4pt">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; padding-right: 5.4pt; padding-left: 5.4pt">Chairman of the Board, Chief Executive Officer and Director</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-right: 5.4pt; padding-left: 5.4pt">&nbsp;</TD>
    <TD STYLE="padding-right: 5.4pt; padding-left: 5.4pt">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; padding-right: 5.4pt; padding-left: 5.4pt">(Principal Executive Officer)</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; padding-right: 5.4pt; padding-left: 5.4pt">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; padding-right: 5.4pt; padding-left: 5.4pt">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; padding-right: 5.4pt; padding-left: 5.4pt">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; padding-right: 5.4pt; padding-left: 5.4pt">Date: August 10, 2018</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; padding-right: 5.4pt; padding-left: 5.4pt">By:</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; padding-right: 5.4pt; padding-left: 5.4pt">/s/ Barry W. Weiner</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-right: 5.4pt; padding-left: 5.4pt">&nbsp;</TD>
    <TD STYLE="padding-right: 5.4pt; padding-left: 5.4pt">&nbsp;</TD>
    <TD STYLE="padding-right: 5.4pt; padding-left: 5.4pt; border-bottom: rgb(153,153,153) 1px solid">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-right: 5.4pt; padding-left: 5.4pt">&nbsp;</TD>
    <TD STYLE="padding-right: 5.4pt; padding-left: 5.4pt">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; padding-right: 5.4pt; padding-left: 5.4pt">Barry W. Weiner</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-right: 5.4pt; padding-left: 5.4pt">&nbsp;</TD>
    <TD STYLE="padding-right: 5.4pt; padding-left: 5.4pt">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; padding-right: 5.4pt; padding-left: 5.4pt">President, Chief Financial Officer, Principal Accounting Officer, Treasurer and Director</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-right: 5.4pt; padding-left: 5.4pt">&nbsp;</TD>
    <TD STYLE="padding-right: 5.4pt; padding-left: 5.4pt">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; padding-right: 5.4pt; padding-left: 5.4pt">(Principal Financial and Accounting Officer)</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; padding-right: 5.4pt; padding-left: 5.4pt">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; padding-right: 5.4pt; padding-left: 5.4pt">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; padding-right: 5.4pt; padding-left: 5.4pt">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-right: 5.4pt; padding-left: 5.4pt">&nbsp;</TD>
    <TD STYLE="padding-right: 5.4pt; padding-left: 5.4pt">&nbsp;</TD>
    <TD STYLE="padding-right: 5.4pt; padding-left: 5.4pt">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; padding-right: 5.4pt; padding-left: 5.4pt">Date: August 10, 2018</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; padding-right: 5.4pt; padding-left: 5.4pt">By:</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; padding-right: 5.4pt; padding-left: 5.4pt">/s/ Gregory M. Bortz</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-right: 5.4pt; padding-left: 5.4pt">&nbsp;</TD>
    <TD STYLE="padding-right: 5.4pt; padding-left: 5.4pt">&nbsp;</TD>
    <TD STYLE="padding-right: 5.4pt; padding-left: 5.4pt; border-bottom: rgb(153,153,153) 1px solid">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-right: 5.4pt; padding-left: 5.4pt">&nbsp;</TD>
    <TD STYLE="padding-right: 5.4pt; padding-left: 5.4pt">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; padding-right: 5.4pt; padding-left: 5.4pt">Gregory M. Bortz</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-right: 5.4pt; padding-left: 5.4pt">&nbsp;</TD>
    <TD STYLE="padding-right: 5.4pt; padding-left: 5.4pt">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; padding-right: 5.4pt; padding-left: 5.4pt">Director</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; padding-right: 5.4pt; padding-left: 5.4pt">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; padding-right: 5.4pt; padding-left: 5.4pt">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; padding-right: 5.4pt; padding-left: 5.4pt">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-right: 5.4pt; padding-left: 5.4pt">&nbsp;</TD>
    <TD STYLE="padding-right: 5.4pt; padding-left: 5.4pt">&nbsp;</TD>
    <TD STYLE="padding-right: 5.4pt; padding-left: 5.4pt">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; padding-right: 5.4pt; padding-left: 5.4pt">Date: August 10, 2018</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; padding-right: 5.4pt; padding-left: 5.4pt">By:</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; padding-right: 5.4pt; padding-left: 5.4pt">/s/ Dov Perlysky</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-right: 5.4pt; padding-left: 5.4pt">&nbsp;</TD>
    <TD STYLE="padding-right: 5.4pt; padding-left: 5.4pt">&nbsp;</TD>
    <TD STYLE="padding-right: 5.4pt; padding-left: 5.4pt; border-bottom: rgb(153,153,153) 1px solid">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-right: 5.4pt; padding-left: 5.4pt">&nbsp;</TD>
    <TD STYLE="padding-right: 5.4pt; padding-left: 5.4pt">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; padding-right: 5.4pt; padding-left: 5.4pt">Dov Perlysky</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-right: 5.4pt; padding-left: 5.4pt">&nbsp;</TD>
    <TD STYLE="padding-right: 5.4pt; padding-left: 5.4pt">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; padding-right: 5.4pt; padding-left: 5.4pt">Director</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; padding-right: 5.4pt; padding-left: 5.4pt">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; padding-right: 5.4pt; padding-left: 5.4pt">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; padding-right: 5.4pt; padding-left: 5.4pt">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-right: 5.4pt; padding-left: 5.4pt">&nbsp;</TD>
    <TD STYLE="padding-right: 5.4pt; padding-left: 5.4pt">&nbsp;</TD>
    <TD STYLE="padding-right: 5.4pt; padding-left: 5.4pt">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; padding-right: 5.4pt; padding-left: 5.4pt">Date: August 10, 2018</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; padding-right: 5.4pt; padding-left: 5.4pt">By:</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; padding-right: 5.4pt; padding-left: 5.4pt">&nbsp; <FONT STYLE="background-color: white">/s/ Bruce A. Hanna</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-right: 5.4pt; padding-left: 5.4pt">&nbsp;</TD>
    <TD STYLE="padding-right: 5.4pt; padding-left: 5.4pt">&nbsp;</TD>
    <TD STYLE="padding-right: 5.4pt; padding-left: 5.4pt; border-bottom: rgb(153,153,153) 1px solid">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-right: 5.4pt; padding-left: 5.4pt">&nbsp;</TD>
    <TD STYLE="padding-right: 5.4pt; padding-left: 5.4pt">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; padding-right: 5.4pt; padding-left: 5.4pt">Bruce A. Hanna, Ph.D.</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-right: 5.4pt; padding-left: 5.4pt">&nbsp;</TD>
    <TD STYLE="padding-right: 5.4pt; padding-left: 5.4pt">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; padding-right: 5.4pt; padding-left: 5.4pt">Director</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; padding-right: 5.4pt; padding-left: 5.4pt">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; padding-right: 5.4pt; padding-left: 5.4pt">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; padding-right: 5.4pt; padding-left: 5.4pt">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-right: 5.4pt; padding-left: 5.4pt">&nbsp;</TD>
    <TD STYLE="padding-right: 5.4pt; padding-left: 5.4pt">&nbsp;</TD>
    <TD STYLE="padding-right: 5.4pt; padding-left: 5.4pt">&nbsp;</TD></TR>
</TABLE>


<P STYLE="font: 10pt Times New Roman, Times, Serif; text-align: center">6</p>



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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-align: left"><FONT STYLE="font-weight: normal">&nbsp;</FONT></P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-align: center">EXHIBIT INDEX</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="width: 100%; border-collapse: collapse">
<TR>
    <TD STYLE="padding-right: 5.4pt; padding-left: 5.4pt">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 3pt 0; border-bottom: Black 0.5pt solid">No.</P></TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; padding: 3pt 5.4pt">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="padding-right: 5.4pt; padding-left: 5.4pt">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 3pt 0; border-bottom: Black 0.5pt solid">Description</P></TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; padding: 3pt 5.4pt">&nbsp;</TD></TR>
<TR>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; padding: 3pt 5.4pt">4.1</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; padding: 3pt 5.4pt">&nbsp;</TD>
    <TD COLSPAN="3" STYLE="font: 10pt Times New Roman, Times, Serif; padding: 3pt 5.4pt"><A HREF="http://www.sec.gov/Archives/edgar/data/316253/000093041305002352/c36807_ex4-1.txt" STYLE="-sec-extract: exhibit">Certificate of Incorporation.(1)</A></TD></TR>
<TR>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; padding: 3pt 5.4pt">4.2</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; padding: 3pt 5.4pt">&nbsp;</TD>
    <TD COLSPAN="3" STYLE="font: 10pt Times New Roman, Times, Serif; padding: 3pt 5.4pt">Certificate of Amendment of the Certificate of Incorporation, Filed March 17, 1980.(1)</TD></TR>
<TR>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; padding: 3pt 5.4pt">4.3</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; padding: 3pt 5.4pt">&nbsp;</TD>
    <TD COLSPAN="3" STYLE="font: 10pt Times New Roman, Times, Serif; padding: 3pt 5.4pt">Certificate of Amendment of the Certificate of Incorporation, Filed June 16, 1981.(1)</TD></TR>
<TR>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; padding: 3pt 5.4pt">4.4</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; padding: 3pt 5.4pt">&nbsp;</TD>
    <TD COLSPAN="3" STYLE="font: 10pt Times New Roman, Times, Serif; padding: 3pt 5.4pt">Certificate of Amendment to the Certificate of Incorporation, Filed July 22, 1988.(1)</TD></TR>
<TR>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; padding: 3pt 5.4pt">4.5</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; padding: 3pt 5.4pt">&nbsp;</TD>
    <TD COLSPAN="3" STYLE="font: 10pt Times New Roman, Times, Serif; padding: 3pt 5.4pt"><A HREF="http://www.sec.gov/Archives/edgar/data/316253/000093041313000254/c72341_ex3-ii.htm" STYLE="-sec-extract: exhibit">Amended and Restated By-Laws.(2)</A></TD></TR>
<TR>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; padding: 3pt 5.4pt">4.6</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; padding: 3pt 5.4pt">&nbsp;</TD>
    <TD COLSPAN="3" STYLE="font: 10pt Times New Roman, Times, Serif; padding: 3pt 5.4pt"><A HREF="http://www.sec.gov/Archives/edgar/data/316253/000093041305002352/c36807_ex4-6.txt" STYLE="-sec-extract: exhibit">Form of Common Stock Certificate.(1)</A></TD></TR>
<TR>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; padding: 3pt 5.4pt">5.1</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; padding: 3pt 5.4pt">&nbsp;</TD>
    <TD COLSPAN="3" STYLE="font: 10pt Times New Roman, Times, Serif; padding: 3pt 5.4pt"><A HREF="c91793_ex5-1.htm">Legal Opinion of McDermott Will &amp; Emery LLP.</A></TD></TR>
<TR>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; padding: 3pt 5.4pt">23.1</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; padding: 3pt 5.4pt">&nbsp;</TD>
    <TD COLSPAN="3" STYLE="font: 10pt Times New Roman, Times, Serif; padding: 3pt 5.4pt"><A HREF="c91793_ex23-1.htm">Consent of EisnerAmper LLP.</A></TD></TR>
<TR>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; padding: 3pt 5.4pt">23.2</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; padding: 3pt 5.4pt">&nbsp;</TD>
    <TD COLSPAN="3" STYLE="font: 10pt Times New Roman, Times, Serif; padding: 3pt 5.4pt"><A HREF="c91793_ex5-1.htm">Consent of McDermott Will &amp; Emery LLP (included in exhibit 5.1).</A></TD></TR>
<TR>
     <TD STYLE="font: 10pt Times New Roman, Times, Serif; padding: 3pt 5.4pt">24.1</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; padding: 3pt 5.4pt">&nbsp;</TD>
    <TD COLSPAN="3" STYLE="font: 10pt Times New Roman, Times, Serif; padding: 3pt 5.4pt"><A HREF="#x1__power">Powers of Attorney of the directors and certain officers of the Company (included on the signature page to the Registration Statement).</A></TD></TR>
<TR>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; padding: 3pt 5.4pt">99.1</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; padding: 3pt 5.4pt">&nbsp;</TD>
    <TD COLSPAN="3" STYLE="font: 10pt Times New Roman, Times, Serif; padding: 3pt 5.4pt"><A HREF="c91793_ex99-1.htm">Enzo Biochem, Inc. Amended And Restated 2011 Incentive Plan.</A></TD></TR>
<TR>
    <TD STYLE="border-bottom: Black 1.5pt solid; font: 10pt Times New Roman, Times, Serif">&nbsp;</TD>
    <TD STYLE="border-bottom: Black 1.5pt solid; font: 10pt Times New Roman, Times, Serif">&nbsp;</TD>
    <TD STYLE="border-bottom: Black 1.5pt solid; font: 10pt Times New Roman, Times, Serif">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="font: 10pt Times New Roman, Times, Serif">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom">
    <TD COLSPAN="5" STYLE="font: 10pt Times New Roman, Times, Serif">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; padding: 3pt 5.4pt">(1)</TD>
    <TD COLSPAN="4" STYLE="font: 10pt Times New Roman, Times, Serif; padding: 3pt 5.4pt">Incorporated by reference from the Company&rsquo;s Registration Statement on Form S-8 (Registration No. 333-123712) filed with the SEC on March 31, 2005.</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; padding: 3pt 5.4pt">(2)</TD>
    <TD COLSPAN="4" STYLE="font: 10pt Times New Roman, Times, Serif; padding: 3pt 5.4pt">Incorporated by reference from the Company&rsquo;s Current Report on Form 8-K filed with the Commission on January 22, 2013.</TD></TR>
<TR>
    <TD STYLE="width: 8%">&nbsp;</TD>
    <TD STYLE="width: 3%">&nbsp;</TD>
    <TD STYLE="width: 8%">&nbsp;</TD>
    <TD STYLE="width: 6%">&nbsp;</TD>
    <TD STYLE="width: 75%">&nbsp;</TD></TR>
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<P STYLE="font: 10pt Times New Roman, Times, Serif; text-align: center">7</p>


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[{"type": "S-8", "sequence": "1", "filename": "c91793_s8.htm", "secsgml_size_bytes": 55006}]
{"company-data": {"conformed-name": "ENZO BIOCHEM INC", "cik": "0000316253", "assigned-sic": "8071", "irs-number": "132866202", "state-of-incorporation": "NY", "fiscal-year-end": "0731"}, "filing-values": {"form-type": "S-8", "act": "33", "file-number": "333-226799", "film-number": "181009928"}, "business-address": {"street1": "60 EXECUTIVE BLVD", "city": "FARMINGDALE", "state": "NY", "zip": "11735", "phone": "5167555500"}, "mail-address": {"street1": "ENZO BIOCHEM INC", "street2": "60 EXECUTIVE BLVD", "city": "FARMINGDALE", "state": "NY", "zip": "11735"}}
As filed with the Securities and Exchange
Commission on August 10, 2018
Registration No. 333-
UNITED STATES
SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM S-8
REGISTRATION
STATEMENT
UNDER
THE SECURITIES ACT OF 1933
ENZO BIOCHEM, INC.
(Exact name of Registrant as specified
in its charter)
New York
(State or Other Jurisdiction
of Incorporation or Organization)
13-2866202
(I.R.S. Employer Identification Number)
527 Madison Avenue
New York, NY
(Address of Principal Executive Offices)
10022
(Zip Code)
ENZO BIOCHEM, INC. AMENDED AND RESTATED 2011 INCENTIVE PLAN
(Full title of the plan)
Barry W. Weiner
President, Chief Financial Officer, Principal
        Accounting Officer, Treasurer and Director Enzo Biochem, Inc.
527 Madison Avenue
New York, NY 10022
(212) 583-0100
(Name and Address of Agent For Service)
Copy to:
Robert H. Cohen, Esq.
McDermott Will & Emery LLP
340 Madison Avenue
New York, NY 10173
(212) 547-5400
Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, or a smaller reporting company. See the definitions of "large accelerated filer," "accelerated filer" and "smaller reporting company" in Rule 12b-2 of the Exchange Act. (Check one):
Large accelerated filer
¨
Accelerated filer
þ
Non-accelerated filer
¨
(Do not check if a smaller
Reporting company)
Smaller reporting company
¨
CALCULATION OF REGISTRATION FEE
Title of securities
to be Registered
Amount to be
registered(1)(2)
Proposed maximum
offering price per share(3)
Proposed maximum
aggregate offering price(3)
Amount of
registration fee
Common Stock,
par value $0.01 per share
2,000,000(4)
$4.41
$8,820,000
$1,098.09
(1)
Pursuant to Rule 416(a) of the Securities Act of 1933, as amended (the "Securities Act"), this Registration Statement also registers any additional shares of Common Stock, par value $0.01 per share ("Common Stock") of Enzo Biochem, Inc. (the "Company"), as may become available or issuable under the Enzo Biochem, Inc. Amended And Restated 2011 Incentive Plan (the "Plan"), to prevent dilution resulting from stock splits, stock dividends, or similar transactions.
(2)
Pursuant to Rule 416(c) under the Securities Act, this Registration Statement also covers an indeterminate amount of interests to be offered or sold pursuant to the Plan.
(3)
Estimated solely for the purpose of determining the amount of the registration fee pursuant to Rule 457(c) and Rule 457(h) under the Securities Act, based on the average of the high and low prices per share of Common Stock as reported on the New York Stock Exchange on August 2, 2018.
(4)
Represents the additional shares of Common Stock  subject to future grants under the Plan.
Explanatory Note
This Registration Statement is filed solely to reflect an increase of 2,000,000 shares of the Registrant's
Common Stock reserved for the Plan. The securities subject to this Registration Statement are of the same class for which the Registrant previously
filed a Registration Statement on Form S-8 under the Securities Act. Accordingly, the contents of the Registrant's Registration
Statement on Form S-8, File No. 333-172127, as filed with the Securities and Exchange Commission (the "Commission")
on February 9, 2011, are hereby incorporated by reference pursuant to General Instruction E to Form S-8, except for item 6 which
is being updated by this Registration Statement.
PART II
INFORMATION REQUIRED IN THE REGISTRATION STATEMENT
ITEM 3. INCORPORATION OF DOCUMENTS BY REFERENCE.
The following documents filed with the
Commission are hereby incorporated by reference into this Registration Statement on Form S-8:
(a)
the Company's Annual Report on Form 10-K for the year ended July 31, 2017, filed with the Commission on September 27,
2017;
(b)
the Company's Quarterly Reports on Form 10-Q for the quarter ended October 31, 2017 filed with the Commission on December
7, 2017, for the quarter ended January 31, 2018 filed with the Commission on March 12, 2018, and for the quarter ended April 30,
2018 filed with the Commission on June 11, 2018;
(c)
the Company's Current Reports on Form 8-K filed with the Commission on October 23, 2017, January 22, 2018, April 24,
2018 and July 18, 2018; and
(d)
the description of the Common Stock set forth in the Company's registration statement on Form 8-A, filed with the Commission
on December 8, 1999.
All documents filed by the Company pursuant
to Section 13(a), 13(c), 14 or 15(d) of the Securities Exchange Act of 1934, as amended, subsequent to the date hereof and
prior to the filing of a post-effective
2
amendment which indicates that all securities offered have been sold or which deregisters
all securities then remaining unsold shall be deemed to be incorporated by reference herein and to be a part hereof from the date
of filing of such documents. Notwithstanding the foregoing, unless specifically stated to the contrary, none of the information
disclosed by the Company under Items 2.02 or 7.01 of any Current Report on Form 8-K that the Company may from time to time furnish
to the Commission will be incorporated by reference into, or otherwise included in, this Registration Statement. Any statement
contained herein or in a document incorporated or deemed to be incorporated by reference herein shall be deemed to be modified
or superseded for purposes of this Registration Statement to the extent that a statement contained herein or in any subsequently
filed document which also is or is deemed to be incorporated by reference herein modifies or supersedes such statement. Any such
statement so modified or superseded shall not be deemed, except as so modified or superseded, to constitute a part of this Registration
Statement.
ITEM 4. DESCRIPTION OF SECURITIES.
Not applicable.
ITEM 5. INTERESTS OF NAMED EXPERTS AND COUNSEL.
Not applicable.
ITEM 6. INDEMNIFICATION OF DIRECTORS AND OFFICERS.
The Company is a New York corporation.
Sections 721 through 726 of the New York Business Corporation Law (the "BCL") provide that, in certain circumstances,
a corporation may indemnify its directors and officers against judgments, fines, amounts paid in settlement and reasonable expenses,
including attorneys' fees, actually and necessarily incurred as a result of any actual or threatened action or proceeding
against such directors or officers, or by or in the right of any other enterprise which such directors or officers served in any
capacity at the request of the corporation, by reason of the fact that such person acted in any of the capacities set forth above,
if such director or officer (i) acted, in good faith, for a purpose which he or she reasonably believed to be in or not opposed
to the best interests of the corporation and (ii) in criminal actions or proceedings, had no reasonable cause to believe that his
or her conduct was unlawful; provided, however, that no indemnification may be provided where a final adjudication adverse to the
director or officer establishes that his or her actions were committed in bad faith or were the result of active and deliberate
dishonesty and were material to the cause of action adjudicated, or that he or she personally gained a financial profit or other
advantage to which he or she was not legally entitled. A corporation is required to indemnify against reasonable expenses (including
attorneys' fees) incurred by any director or officer who successfully defends any such action. The BCL also provides for
indemnification of officers and directors in actions by or in the right of the corporation, subject to certain exceptions. Indemnification
provided by these provisions of the BCL is not exclusive of any other rights to which a director or officer may be entitled. The
foregoing statements are subject to the detailed provisions of the BCL.
The Company's Certificate of Incorporation,
as amended, states the following:
"Article 8. The Corporation shall,
to the fullest extent permitted by the Business Corporation Law of the States of New York, indemnify any and all persons whom it
shall have power to indemnify from and against any and all of the expenses, liabilities or other matters as provided under Articles
of Seven of the Business Corporation Law of the State of New York."
"Article 12. No director of the
Corporation shall be liable to the Corporation or its shareholders for damage for any breach of duty in such capacity, provided
that nothing contained in this Article shall eliminate or limit the liability of a director (i) if a judgment or other final adjudication
adverse to him establishes that his acts or omissions were in bad faith or involved acts or omissions were in bad faith or involved
intentional misconduct or a knowing violation of law or that he personally gained in fact a financial profit or other advantage
to which he was not legally entitled or that his acts violated Section 719 of the New York Business Corporation Law or (ii) for
any act or omission prior to July 8, 1988."
ARTICLE V of the Company's By-Laws
provides as follows:
3
"The Corporation shall, to the
fullest extent permitted by the laws of the State of incorporation, indemnify any and all persons whom it shall have power to indemnify
against any and all of the costs, expenses, liabilities or other matters incurred by them by reason of having been officers or
directors of the Corporation, any subsidiary of the Corporation or of any other corporation for which he acted as officer or director
at the request of the Corporation."
The Company has also obtained directors'
and officers' liability insurance, which insures against liabilities that the Company's directors or officers may incur
in such capabilities.
ITEM 7. EXEMPTION FROM REGISTRATION CLAIMED.
Not applicable.
ITEM 8. EXHIBITS
See attached Exhibit Index.
ITEM 9. UNDERTAKINGS.
(a)        The
Company hereby undertakes:
(1) To file, during any period
in which offers or sales are being made, a post-effective amendment to this Registration Statement:
(i)
to include any prospectus required by Section 10(a)(3) of the Securities Act;
(ii)
to reflect in the prospectus any facts or events arising after the effective date of this Registration Statement (or the most
recent post-effective amendment thereof) which, individually or in the aggregate, represent a fundamental change in the information
set forth in this Registration Statement;
(iii)
to include any material information with respect to the plan of distribution not previously disclosed in this Registration
Statement or any material change to such information in this Registration Statement;
Provided, however
, that paragraphs
(a)(1)(i) and (a)(1)(ii) do not apply if the registration statement is on Form S-8, and the information required to be included
in a post-effective amendment by those paragraphs is contained in reports filed with or furnished to the Commission by the Company
pursuant to Section 13 or Section 15(d) of the Exchange Act that are incorporated by reference in this Registration Statement.
(2) That, for the purpose of determining
any liability under the Securities Act, each such post-effective amendment shall be deemed to be a new registration statement relating
to the securities offered therein, and the offering of such securities at that time shall be deemed to be the initial
bona fide
offering thereof.
(3) To remove from registration
by means of a post-effective amendment any of the securities being registered which remain unsold at the termination of the offering.
(b) The Company hereby undertakes that,
for purposes of determining any liability under the Securities Act, each filing of the Company's annual report pursuant to
Section 13(a) or Section 15(d) of the Exchange Act (and, where applicable, each filing of an employee benefit plan's annual
report pursuant to Section 15(d) of the Exchange Act) that is incorporated by reference in this Registration Statement will be
deemed to be a new registration statement relating to the securities offered therein, and the offering of such securities at that
time shall be deemed to be the initial
bona fide
offering thereof.
(c) Insofar as indemnification for liabilities
arising under the Securities Act of may be permitted to directors, officers and controlling persons of the Company pursuant to
the foregoing provisions, or otherwise, the
4
Company has been advised that in the opinion of the Commission such indemnification
is against public policy as expressed in the Securities Act and is, therefore, unenforceable. In the event that a claim for indemnification
against such liabilities (other than the payment by the Company of expenses incurred or paid by a director, officer or controlling
person of the Company in the successful defense of any action, suit or proceeding) is asserted by such director, officer or controlling
person in connection with the securities being registered, the Company will, unless in the opinion of its counsel the matter has
been settled by controlling precedent, submit to a court of appropriate jurisdiction the question whether such indemnification
by it is against public policy as expressed in the Securities Act and will be governed by the final adjudication of such issue.
5
SIGNATURES
Pursuant to the requirements of the Securities
Act of 1933, the Company certifies that it has reasonable grounds to believe that it meets all of the requirements for filing on
Form S-8 and has duly caused this registration statement to be signed on its behalf by the undersigned, thereunto duly authorized,
in the City of New York, State of New York, on August 10, 2018.
ENZO BIOCHEM, INC.
By:
/s/ Elazar Rabbani, Ph.D.
Elazar Rabbani, Ph.D.
Chairman of the Board, Chief Executive Officer and Director (Principal
        Executive Officer)
POWER OF ATTORNEY
KNOW ALL PERSONS BY THESE PRESENT, that
each person whose signature appears below constitutes and appoints Elazar Rabbani and Barry W. Weiner, and each or either of them,
his true and lawful attorney-in-fact and agent, with full power of substitution and resubstitution, for him and in his name, place
and stead, in any and all capacities, to sign any and all amendments, including post-effective amendments, to this Form S-8 Registration
Statement, and to file the same, with all exhibits thereto, and other documents in connection therewith, with the Securities and
Exchange Commission, granting unto said attorneys-in-fact and agents, and each of them, full power and authority to do and perform
each and every act and thing requisite and necessary to be done in connection therewith, as fully to all intents and purposes as
he might or could do in person, hereby ratifying and confirming all that said attorneys-in-fact and agents, or any of them, or
their or his substitutes or substitute, may lawfully do or cause to be done by virtue hereof.
Pursuant to the requirements of the Securities
Act of 1933, this Registration Statement has been signed below by the following persons in the capacities and on the dates indicated.
Date: August 10, 2018
By:
/s/ Elazar Rabbani, Ph.D.
Elazar Rabbani, Ph.D.
Chairman of the Board, Chief Executive Officer and Director
(Principal Executive Officer)
Date: August 10, 2018
By:
/s/ Barry W. Weiner
Barry W. Weiner
President, Chief Financial Officer, Principal Accounting Officer, Treasurer and Director
(Principal Financial and Accounting Officer)
Date: August 10, 2018
By:
/s/ Gregory M. Bortz
Gregory M. Bortz
Director
Date: August 10, 2018
By:
/s/ Dov Perlysky
Dov Perlysky
Director
Date: August 10, 2018
By:
/s/ Bruce A. Hanna
Bruce A. Hanna, Ph.D.
Director
6
EXHIBIT INDEX
No.
Description
4.1
Certificate of Incorporation.(1)
4.2
Certificate of Amendment of the Certificate of Incorporation, Filed March 17, 1980.(1)
4.3
Certificate of Amendment of the Certificate of Incorporation, Filed June 16, 1981.(1)
4.4
Certificate of Amendment to the Certificate of Incorporation, Filed July 22, 1988.(1)
4.5
Amended and Restated By-Laws.(2)
4.6
Form of Common Stock Certificate.(1)
5.1
Legal Opinion of McDermott Will & Emery LLP.
23.1
Consent of EisnerAmper LLP.
23.2
Consent of McDermott Will & Emery LLP (included in exhibit 5.1).
24.1
Powers of Attorney of the directors and certain officers of the Company (included on the signature page to the Registration Statement).
99.1
Enzo Biochem, Inc. Amended And Restated 2011 Incentive Plan.
(1)
Incorporated by reference from the Company's Registration Statement on Form S-8 (Registration No. 333-123712) filed with the SEC on March 31, 2005.
(2)
Incorporated by reference from the Company's Current Report on Form 8-K filed with the Commission on January 22, 2013.
7