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<p style="margin: 0pt 0pt 6pt; font-family: &quot;Times New Roman&quot;, Times, serif; font-size: 10pt; text-align: center; text-indent: 0pt;"><b>As filed with the Securities and Exchange Commission on June 5, 2024</b></p>

<p style="margin: 6pt 0pt 0pt; font-family: &quot;Times New Roman&quot;, Times, serif; font-size: 10pt; text-align: right; text-indent: 0pt;"><b>Registration No. 333-</b></p>

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<p style="font-family: &quot;Times New Roman&quot;; font-size: 16pt; font-variant: normal; margin: 0pt; text-align: center;"><b>UNITED STATES</b></p>

<p style="font-family: &quot;Times New Roman&quot;; font-size: 16pt; font-variant: normal; text-align: center; margin: 0pt;"><b>SECURITIES AND EXCHANGE COMMISSION</b></p>

<p style="font-family: &quot;Times New Roman&quot;, Times, serif; font-size: 10pt; font-variant: normal; text-align: center; margin: 0pt 0pt 6pt; text-indent: 0pt;"><b>WASHINGTON, D.C. 20549</b></p>

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<p style="font-family: &quot;Times New Roman&quot;, Times, serif; font-size: 16pt; font-variant: normal; text-align: center; margin: 6pt 0pt 3pt; text-indent: 0pt;"><b>FORM S-8</b></p>

<p style="font-family: &quot;Times New Roman&quot;, Times, serif; font-size: 10pt; font-variant: normal; text-align: center; margin: 0pt; text-indent: 0pt;"><b>REGISTRATION STATEMENT</b></p>

<p style="font-family: &quot;Times New Roman&quot;, Times, serif; font-size: 10pt; font-variant: normal; text-align: center; margin: 0pt; text-indent: 0pt;"><b>UNDER</b></p>

<p style="font-family: &quot;Times New Roman&quot;, Times, serif; font-size: 10pt; font-variant: normal; text-align: center; margin: 0pt 0pt 6pt; text-indent: 0pt;"><b>THE SECURITIES ACT OF 1933</b></p>

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<p style="font-family: &quot;Times New Roman&quot;, Times, serif; font-size: 22pt; font-variant: normal; text-align: center; margin: 6pt 0pt 3pt; text-indent: 0pt;"><b>CLENE INC.</b></p>

<p style="font-family: &quot;Times New Roman&quot;, Times, serif; font-size: 8pt; font-variant: normal; margin: 3pt 0pt 6pt; text-align: center; text-indent: 0pt;">(Exact name of registrant as specified in its charter)</p>

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<p style="font-family: &quot;Times New Roman&quot;; font-size: 6pt; font-variant: normal; margin: 0pt;">&nbsp;</p>

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			<p style="font-family:Times New Roman;font-size:10pt;font-variant:normal;text-align:center;margin:0pt;"><b>Delaware</b></p>
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			<p style="font-family:Times New Roman;font-size:10pt;font-variant:normal;text-align:center;margin:0pt;">&nbsp;</p>
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			<p style="font-family:Times New Roman;font-size:10pt;font-variant:normal;text-align:center;margin:0pt;"><b>85-2828339</b></p>
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			<td style="vertical-align: top; width: 45%;">
			<p style="font-family: &quot;Times New Roman&quot;; font-size: 8pt; font-variant: normal; text-align: center; margin: 0pt;">(State or other jurisdiction</p>
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			<td style="vertical-align: top; width: 10%;">
			<p style="font-family: &quot;Times New Roman&quot;; font-size: 8pt; font-variant: normal; text-align: center; margin: 0pt;">&nbsp;</p>
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			<td style="vertical-align: top; width: 45%;">
			<p style="font-family: &quot;Times New Roman&quot;; font-size: 8pt; font-variant: normal; text-align: center; margin: 0pt;">(I.R.S. Employer</p>
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			<p style="font-family: &quot;Times New Roman&quot;; font-size: 8pt; font-variant: normal; text-align: center; margin: 0pt;">of incorporation or organization)</p>
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			<td style="vertical-align: top; width: 10%; font-size: 8pt;">&nbsp;</td>
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			<p style="font-family: &quot;Times New Roman&quot;; font-size: 8pt; font-variant: normal; text-align: center; margin: 0pt;">Identification No.)</p>
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			<td style="vertical-align: top; width: 45%; font-size: 8pt;">&nbsp;</td>
			<td style="vertical-align: top; width: 10%; font-size: 8pt;">&nbsp;</td>
			<td style="vertical-align: top; width: 45%; font-size: 8pt;">&nbsp;</td>
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			<p style="font-family:Times New Roman;font-size:10pt;font-variant:normal;text-align:center;margin:0pt;"><b>6550 South Millrock Drive, Suite G50</b></p>

			<p style="font-family:Times New Roman;font-size:10pt;font-variant:normal;text-align:center;margin:0pt;"><b>Salt Lake City, Utah</b></p>
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			<td style="vertical-align: top; width: 10%;">&nbsp;</td>
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			<p style="font-family:Times New Roman;font-size:10pt;font-variant:normal;text-align:center;margin:0pt;"><b>84121</b></p>
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			<td style="vertical-align: top; width: 45%;">
			<p style="font-family: &quot;Times New Roman&quot;; font-size: 8pt; font-variant: normal; text-align: center; margin: 0pt;">(Address of Principal Executive Offices)</p>
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			<td style="vertical-align: top; width: 10%; font-size: 8pt;">&nbsp;</td>
			<td style="vertical-align: top; width: 45%;">
			<p style="font-family: &quot;Times New Roman&quot;; font-size: 8pt; font-variant: normal; text-align: center; margin: 0pt;">(Zip Code)</p>
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<p style="font-family: &quot;Times New Roman&quot;, Times, serif; font-size: 10pt; font-variant: normal; margin: 6pt 0pt 3pt; text-align: center; text-indent: 0pt;"><b>Clene Inc. Amended 2020 Stock Plan</b></p>

<p style="font-family: &quot;Times New Roman&quot;, Times, serif; font-size: 8pt; font-variant: normal; margin: 3pt 0pt 6pt; text-align: center; text-indent: 0pt;">(Full title of the plan)</p>

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<p style="font-family: &quot;Times New Roman&quot;, Times, serif; font-size: 10pt; font-variant: normal; margin: 6pt 0pt 0pt; text-align: center; text-indent: 0pt;"><b>Robert Etherington</b></p>

<p style="font-family: &quot;Times New Roman&quot;; font-size: 10pt; font-variant: normal; margin: 0pt; text-align: center;"><b>President and Chief Executive Officer</b></p>

<p style="font-family: &quot;Times New Roman&quot;; font-size: 10pt; font-variant: normal; margin: 0pt; text-align: center;"><b>6550 South Millrock Drive, Suite G50</b></p>

<p style="font-family: &quot;Times New Roman&quot;, Times, serif; font-size: 10pt; font-variant: normal; margin: 0pt 0pt 3pt; text-align: center; text-indent: 0pt;"><b>Salt Lake City, Utah 84121</b></p>

<p style="font-family: &quot;Times New Roman&quot;, Times, serif; font-size: 8pt; font-variant: normal; margin: 3pt 0pt 6pt; text-align: center; text-indent: 0pt;">(Name and address of agent for service)</p>

<p style="font-family: &quot;Times New Roman&quot;, Times, serif; font-size: 10pt; font-variant: normal; margin: 6pt 0pt 3pt; text-align: center; text-indent: 0pt;"><b>(801) 676-9695</b></p>

<p style="font-family: &quot;Times New Roman&quot;, Times, serif; font-size: 8pt; font-variant: normal; margin: 3pt 0pt 6pt; text-align: center; text-indent: 0pt;">(Telephone number, including area code, of agent for service)</p>

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<p style="font-family: &quot;Times New Roman&quot;, Times, serif; font-size: 10pt; font-variant: normal; margin: 6pt 0pt; text-align: center; text-indent: 0pt;"><b>Copies to:</b></p>

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			<p style="font-family:Times New Roman;font-size:10pt;font-variant:normal;text-align:center;margin:0pt;"><b>Jerry Miraglia, Esq.</b></p>
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			<p style="font-family:Times New Roman;font-size:10pt;font-variant:normal;text-align:center;margin:0pt;">&nbsp;</p>
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			<td style="vertical-align: top; width: 45%;">
			<p style="font-family:Times New Roman;font-size:10pt;font-variant:normal;text-align:center;margin:0pt;"><b>Tom McAleavey</b></p>
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			<p style="font-family: &quot;Times New Roman&quot;; font-size: 10pt; font-variant: normal; text-align: center; margin: 0pt;"><b>General Counsel and Corporate Secretary</b></p>
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			<p style="font-family: &quot;Times New Roman&quot;; font-size: 10pt; font-variant: normal; text-align: center; margin: 0pt;">&nbsp;</p>
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			<td style="vertical-align: top; width: 45%;">
			<p style="font-family: &quot;Times New Roman&quot;; font-size: 10pt; font-variant: normal; text-align: center; margin: 0pt;"><b>Holland &amp; Knight LLP</b></p>
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			<td style="vertical-align: top; width: 45%;">
			<p style="font-family: &quot;Times New Roman&quot;; font-size: 10pt; font-variant: normal; text-align: center; margin: 0pt;"><b>6550 South Millrock Drive, Suite G50</b></p>
			</td>
			<td style="vertical-align: top; width: 10%; font-size: 10pt;">&nbsp;</td>
			<td style="vertical-align: top; width: 45%;">
			<p style="font-family: &quot;Times New Roman&quot;; font-size: 10pt; font-variant: normal; text-align: center; margin: 0pt;"><b>200 South Orange Avenue, Suite 2600</b></p>
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			<td style="vertical-align: top; width: 45%; font-size: 10pt; text-align: center;"><b>Salt Lake City, Utah 84121</b></td>
			<td style="vertical-align: top; width: 10%; font-size: 10pt;">&nbsp;</td>
			<td style="vertical-align: top; width: 45%; font-size: 10pt; text-align: center;"><b>Orlando, Florida 32801</b></td>
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			<p style="font-family:Times New Roman;font-size:10pt;font-variant:normal;text-align:center;margin:0pt;"><b>Tel: (801) 676-9695</b></p>
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			<td style="vertical-align: top; width: 10%;">&nbsp;</td>
			<td style="vertical-align: bottom; width: 45%;">
			<p style="font-family:Times New Roman;font-size:10pt;font-variant:normal;text-align:center;margin:0pt;"><b>Tel: (407) 244-5108</b></p>
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<p style="margin: 0pt; font-family: &quot;Times New Roman&quot;; font-size: 6pt;">&nbsp;</p>

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<p style="font-family: &quot;Times New Roman&quot;, Times, serif; font-size: 9pt; font-variant: normal; margin: 6pt 0pt; text-align: left; text-indent: 0pt;">Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, a smaller reporting company or an emerging growth company. See the definitions of&nbsp;&#8220;large accelerated filer,&#8221;&nbsp;&#8220;accelerated filer,&#8221; &#8220;smaller reporting company,&#8221; and&nbsp;&#8220;emerging growth company&#8221; in Rule 12b-2 of the Exchange Act:</p>

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			<td style="width: 25%; font-size: 9pt;">Large accelerated filer</td>
			<td style="width: 25%; font-size: 9pt;">&#9744;</td>
			<td style="width: 25%; font-size: 9pt;">Accelerated filer</td>
			<td style="width: 25%; font-size: 9pt;">&#9744;</td>
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			<td style="font-size: 9pt;">Non-accelerated filer</td>
			<td style="font-size: 9pt;">&#9746;</td>
			<td style="font-size: 9pt;">Smaller reporting company</td>
			<td style="font-size: 9pt;">&#9746;</td>
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			<td style="font-size: 9pt;">&nbsp;</td>
			<td style="font-size: 9pt;">&nbsp;</td>
			<td style="font-size: 9pt;">Emerging growth company</td>
			<td style="font-size: 9pt;">&#9744;</td>
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<p style="font-family: &quot;Times New Roman&quot;, Times, serif; font-size: 9pt; font-variant: normal; margin: 6pt 0pt; text-align: left; text-indent: 0pt;">If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 7(a)(2)(B) of the Securities Act.&nbsp;&#9744;</p>

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<p style="font-family: &quot;Times New Roman&quot;; font-size: 10pt; font-variant: normal; margin: 0pt; text-align: center;"><b><a id="EXPLANTORY_NOTE" name="EXPLANTORY_NOTE" title="EXPLANTORY_NOTE"></a>EXPLANATORY NOTE</b></p>

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<p style="font-family:'Times New Roman';font-size:10pt;font-variant:normal;margin:0pt;">This registration statement on Form S-8 (the&nbsp;&#8220;Registration Statement&#8221;) is filed by Clene Inc. (the&nbsp;&#8220;Company&#8221;), pursuant to General Instruction E to Form S-8&nbsp;under the Securities Act of 1933, as amended, to register 30,000,000 additional shares of the Company&#8217;s common stock, par value $0.0001 per share (the &#8220;Common Stock&#8221;), under the Clene Inc. Amended 2020 Stock Plan (the&nbsp;&#8220;2020 Stock Plan&#8221;). The amendment to increase the number of shares of Common Stock reserved for issuance under the 2020 Stock Plan from 18,400,000 to 48,400,000 was approved by the Board of Directors of the Company on April 3, 2024, and by the stockholders of the Company on May 29, 2024. This Registration Statement hereby incorporates by reference the contents of the Company&#8217;s registration statement&nbsp;on <a href="http://www.sec.gov/Archives/edgar/data/1822791/000121390021018143/ea137949-s8_cleneinc.htm" style="-sec-extract:exhibit;">Form S-8 filed with the Securities and Exchange Commission on March 29, 2021 (Registration No. 333-254810)</a>&nbsp;and registration statement on <a href="http://www.sec.gov/Archives/edgar/data/1822791/000143774923017740/clnn20230519_s8.htm" style="-sec-extract:exhibit;">Form S-8 filed with the Securities and Exchange Commission on June 16, 2023 (Registration No. 333-272744)</a>, to the extent not modified or superseded hereby or by any subsequently filed document, which is incorporated by reference herein or therein.</p>

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<p style="font-family: &quot;Times New Roman&quot;, Times, serif; font-size: 10pt; margin: 0pt; text-align: center;"><b><a id="PART_II" name="PART_II" title="PART_II"></a>PART II</b></p>

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<p style="font-family: &quot;Times New Roman&quot;; font-size: 10pt; font-variant: normal; margin: 0pt; text-align: center;"><b>Information Required in the Registration Statement</b></p>

<p style="font-family: &quot;Times New Roman&quot;; font-size: 10pt; font-variant: normal; margin: 0pt;">&nbsp;</p>

<p style="font-family: &quot;Times New Roman&quot;; font-size: 10pt; font-variant: normal; margin: 0pt;"><b><a id="ITEM_8_EXHIBITS" name="ITEM_8_EXHIBITS" title="ITEM_8_EXHIBITS"></a>Item 8. Exhibits.</b></p>

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			<td style="width: 7%; font-size: 8pt; text-align: center; border-bottom: 1px solid rgb(0, 0, 0);"><b>Exhibit Number</b></td>
			<td style="width: 1%; font-size: 8pt;">&nbsp;</td>
			<td style="width: 92%; font-size: 8pt; text-align: center; border-bottom: 1px solid rgb(0, 0, 0);"><b>Exhibit Description</b></td>
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			<td style="width: 7%; vertical-align: top;">3.1</td>
			<td style="width: 1%; vertical-align: top;">&nbsp;</td>
			<td style="width: 92%; vertical-align: top;"><a href="http://www.sec.gov/Archives/edgar/data/1822791/000143774923013721/ex_517370.htm" style="-sec-extract:exhibit;">Fourth Amended and Restated Certificate of Incorporation of Clene Inc. (incorporated by reference to Exhibit 3.1 to the Current Report on Form 8-K filed by the Registrant on May 11, 2023).</a></td>
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			<td style="width: 7%; vertical-align: top;">3.2</td>
			<td style="width: 1%; vertical-align: top;">&nbsp;</td>
			<td style="width: 92%; vertical-align: top;"><a href="http://www.sec.gov/ix?doc=/Archives/edgar/data/0001822791/000143774924018759/clnn20240528_8k.htm" style="-sec-extract:exhibit;">Certificate of Amendment to the Fourth Amended and Restated Certificate of Incorporation of Clene Inc. (incorporated by reference to Exhibit 3.1 to the Current Report on Form 8-K filed by the Registrant on May 30, 2024).</a></td>
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			<td style="width: 7%; vertical-align: top;">3.3</td>
			<td style="width: 1%; vertical-align: top;">&nbsp;</td>
			<td style="width: 92%; vertical-align: top;"><a href="http://www.sec.gov/ix?doc=/Archives/edgar/data/0001822791/000143774924007542/clnn20231231_10k.htm" style="-sec-extract:exhibit;">Bylaws of Clene Inc. (incorporated by reference to Exhibit 3.2 to the Current Report on Form 8-K filed by the Registrant on January 5, 2021).</a></td>
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			<td style="width: 7%; vertical-align: top;">5.1*</td>
			<td style="width: 1%; vertical-align: top;">&nbsp;</td>
			<td style="width: 92%; vertical-align: top;"><a href="ex_679408.htm" style="-sec-extract:exhibit;">Opinion of Holland &amp; Knight LLP.</a></td>
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			<td style="width: 7%; vertical-align: top;">23.1*</td>
			<td style="width: 1%; vertical-align: top;">&nbsp;</td>
			<td style="width: 92%; vertical-align: top;"><a href="ex_679408.htm" style="-sec-extract:exhibit;">Consent of Holland &amp; Knight LLP (included as part of Exhibit 5.1).</a></td>
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			<td style="width: 7%; vertical-align: top;">23.2*</td>
			<td style="width: 1%; vertical-align: top;">&nbsp;</td>
			<td style="width: 92%; vertical-align: top;"><a href="ex_679409.htm" style="-sec-extract:exhibit;">Consent of Deloitte &amp; Touche LLP.</a></td>
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			<td style="width: 7%; vertical-align: top;">24.1*</td>
			<td style="width: 1%; vertical-align: top;">&nbsp;</td>
			<td style="width: 92%; vertical-align: top;"><a href="#POWER_OF_ATTORNEY" style="-sec-extract:exhibit;">Power of Attorney (included on signature page of the Registration Statement).</a></td>
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			<td style="width: 7%; vertical-align: top;">99.1</td>
			<td style="width: 1%; vertical-align: top;">&nbsp;</td>
			<td style="width: 92%; vertical-align: top;"><a href="http://www.sec.gov/ix?doc=/Archives/edgar/data/0001822791/000143774924018759/clnn20240528_8k.htm" style="-sec-extract:exhibit;">Clene Inc. Amended 2020 Stock Plan&nbsp;(incorporated by reference to Exhibit 10.1 to the Current Report on Form 8-K filed by the Registrant on May 30, 2024).</a></td>
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			<td style="width: 7%; vertical-align: top;">107*</td>
			<td style="width: 1%; vertical-align: top;">&nbsp;</td>
			<td style="width: 92%; vertical-align: top;"><a href="ex_679410.htm" style="-sec-extract:exhibit;">Filing Fee Table.</a></td>
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<p style="margin: 0pt; font-family: &quot;Times New Roman&quot;; font-size: 8pt;">*Filed herewith.</p>

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<p style="font-family: &quot;Times New Roman&quot;, Times, serif; font-size: 10pt; margin: 0pt; text-align: center;"><b><a id="SIGNATURES" name="SIGNATURES" title="SIGNATURES"></a>SIGNATURES</b></p>

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<p style="font-family: &quot;Times New Roman&quot;, Times, serif; font-size: 10pt; margin: 0pt;">Pursuant to the requirements of the Securities Act of 1933, as amended, the registrant certifies that it has reasonable grounds to believe that it meets all of the requirements for filing on Form S-8&nbsp;and has duly caused this Registration Statement to be signed on its behalf by the undersigned, thereunto duly authorized, in Salt Lake City, Utah, on June 5, 2024.</p>

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			<p style="margin: 0px 0pt; font-size: 10pt; font-family: &quot;Times New Roman&quot;, Times, serif;"><font style="font-family: 'Times New Roman', Times, serif; font-size: 10pt">&nbsp;</font></p>
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			<td style="width: 3%;" valign="top" width="38%">
			<p style="margin: 0px 0pt; font-size: 10pt; font-family: &quot;Times New Roman&quot;, Times, serif;"><font style="font-family: 'Times New Roman', Times, serif; font-size: 10pt">&nbsp;</font></p>
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			<td style="width: 35%;" valign="top" width="38%">&nbsp;</td>
			<td style="width: 12%;" valign="top" width="12%">
			<p style="margin: 0px 0pt; font-size: 10pt; font-family: &quot;Times New Roman&quot;, Times, serif;"><font style="font-family: 'Times New Roman', Times, serif; font-size: 10pt">&nbsp;</font></p>
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			<p style="margin: 0px 0pt; font-size: 10pt; font-family: &quot;Times New Roman&quot;, Times, serif;"><font style="font-family: 'Times New Roman', Times, serif; font-size: 10pt">&nbsp;</font></p>
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			<td colspan="2" rowspan="1" style="width: 3%;" valign="top" width="3%">
			<p style="margin: 0px 0pt; font-size: 10pt; font-family: &quot;Times New Roman&quot;, Times, serif;">CLENE INC.</p>
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			<td style="width: 3%;" valign="top" width="3%">
			<p style="margin: 0px 0pt; font-size: 10pt; font-family: &quot;Times New Roman&quot;, Times, serif;"><font style="font-family: 'Times New Roman', Times, serif; font-size: 10pt">&nbsp;</font></p>
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			<p style="margin: 0px 0pt; font-size: 10pt; font-family: &quot;Times New Roman&quot;, Times, serif;"><font style="font-family: 'Times New Roman', Times, serif; font-size: 10pt">&nbsp;</font></p>
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			<p style="margin: 0px 0pt; font-size: 10pt; font-family: &quot;Times New Roman&quot;, Times, serif;"><font style="font-family: 'Times New Roman', Times, serif; font-size: 10pt">&nbsp;</font></p>
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			<p style="margin: 0px 0pt; font-size: 10pt; font-family: &quot;Times New Roman&quot;, Times, serif;"><font style="font-family: 'Times New Roman', Times, serif; font-size: 10pt">&nbsp;</font></p>
			</td>
			<td style="text-align: left; width: 3%;" valign="top" width="3%">
			<p style="margin: 0px 0pt; font-size: 10pt; font-family: &quot;Times New Roman&quot;, Times, serif;"><font style="font-family: 'Times New Roman', Times, serif; font-size: 10pt">By: </font></p>
			</td>
			<td align="left" nowrap="nowrap" style="border-bottom: 1px solid rgb(0, 0, 0); width: 35%;" valign="top" width="35%">
			<p style="margin: 0px 0pt; font-size: 10pt; font-family: &quot;Times New Roman&quot;, Times, serif;"><font style="font-family: 'Times New Roman', Times, serif; font-size: 10pt">/s/ Robert Etherington</font></p>
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			<td style="width: 12%;" valign="top" width="12%">
			<p style="margin: 0px 0pt; font-size: 10pt; font-family: &quot;Times New Roman&quot;, Times, serif;"><font style="font-family: 'Times New Roman', Times, serif; font-size: 10pt">&nbsp;</font></p>
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			<p style="margin: 0px 0pt; font-size: 10pt; font-family: &quot;Times New Roman&quot;, Times, serif;"><font style="font-family: 'Times New Roman', Times, serif; font-size: 10pt">&nbsp;</font></p>
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			<td style="width: 3%;" valign="top" width="3%">
			<p style="margin: 0px 0pt; font-size: 10pt; font-family: &quot;Times New Roman&quot;, Times, serif;"><font style="font-family: 'Times New Roman', Times, serif; font-size: 10pt">&nbsp;</font></p>
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			<td style="width: 35%;" valign="top" width="35%">
			<p style="margin: 0px 0pt; font-size: 10pt; font-family: &quot;Times New Roman&quot;, Times, serif;"><font style="font-family: 'Times New Roman', Times, serif; font-size: 10pt">Robert Etherington</font></p>
			</td>
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			<p style="margin: 0px 0pt; font-size: 10pt; font-family: &quot;Times New Roman&quot;, Times, serif;"><font style="font-family: 'Times New Roman', Times, serif; font-size: 10pt">&nbsp;</font></p>
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			<p style="margin: 0px 0pt; font-size: 10pt; font-family: &quot;Times New Roman&quot;, Times, serif;"><font style="font-family: 'Times New Roman', Times, serif; font-size: 10pt">&nbsp;</font></p>
			</td>
			<td style="width: 3%;" valign="top" width="3%">
			<p style="margin: 0px 0pt; font-size: 10pt; font-family: &quot;Times New Roman&quot;, Times, serif;"><font style="font-family: 'Times New Roman', Times, serif; font-size: 10pt">&nbsp;</font></p>
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			<p style="margin: 0px 0pt; font-size: 10pt; font-family: &quot;Times New Roman&quot;, Times, serif;">President and Chief Executive Officer</p>
			</td>
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			<p style="margin: 0px 0pt; font-size: 10pt; font-family: &quot;Times New Roman&quot;, Times, serif;"><font style="font-family: 'Times New Roman', Times, serif; font-size: 10pt">&nbsp;</font></p>
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<p style="margin: 0pt; font-family: &quot;Times New Roman&quot;; font-size: 10pt; text-align: center;"><b><a id="POWER_OF_ATTORNEY" name="POWER_OF_ATTORNEY" title="POWER_OF_ATTORNEY"></a>POWER OF ATTORNEY</b></p>

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<p style="margin: 0pt; font-family: &quot;Times New Roman&quot;; font-size: 10pt;">Each person whose signature appears below constitutes and appoints Robert Etherington attorney-in-fact, as his or her true and lawful attorney-in-fact and agent, with full power of substitution and resubstitution, for such person and in his or her name, place and stead, in any and all capacities, to sign any or all further amendments (including post-effective amendments) to this Registration Statement (and any additional registration statement related hereto permitted by Rule 462(b) promulgated under the Securities Act, (and all further amendments, including post-effective amendments, thereto)), and to file the same, with all exhibits thereto, and other documents in connection therewith, with the Securities and Exchange Commission, granting unto said attorneys-in-fact and agent&nbsp;full power and authority to do and perform each and every act and thing requisite and necessary to be done in and about the premises, as fully to all intents and purposes as he might or could do in person, hereby ratifying and confirming all that said attorney-in-fact and agent, or his substitute or substitutes, may lawfully do or cause to be done by virtue hereof. Pursuant to the requirements of the Securities Act of 1933, as amended, this Registration Statement has been signed by the following persons in the capacities and on the dates indicated.</p>

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			<td style="width: 32%; text-align: center; border-bottom: 1px solid rgb(0, 0, 0); font-size: 8pt;"><b>Signature</b></td>
			<td style="width: 1%; font-size: 8pt;">&nbsp;</td>
			<td style="width: 42%; font-size: 8pt; text-align: center; border-bottom: 1px solid rgb(0, 0, 0);"><b>Title</b></td>
			<td style="width: 1%; font-size: 8pt;">&nbsp;</td>
			<td style="width: 24%; font-size: 8pt; text-align: center; border-bottom: 1px solid rgb(0, 0, 0);"><b>Date</b></td>
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			<td style="width: 32%;">&nbsp;</td>
			<td style="width: 1%;">&nbsp;</td>
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			<td style="width: 32%; text-align: center; border-bottom: 1px solid rgb(0, 0, 0);">/s/ Robert Etherington</td>
			<td style="width: 1%;">&nbsp;</td>
			<td style="width: 42%; text-align: center;">President, Chief Executive Officer, and Director</td>
			<td style="width: 1%;">&nbsp;</td>
			<td style="width: 24%; text-align: center;">June 5, 2024</td>
		</tr>
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			<td style="width: 32%; text-align: center;">Robert Etherington</td>
			<td style="width: 1%;">&nbsp;</td>
			<td style="width: 42%; text-align: center;">(Principal Executive Officer)</td>
			<td style="width: 1%;">&nbsp;</td>
			<td style="width: 24%;">&nbsp;</td>
		</tr>
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			<td style="width: 32%;">&nbsp;</td>
			<td style="width: 1%;">&nbsp;</td>
			<td style="width: 42%;">&nbsp;</td>
			<td style="width: 1%;">&nbsp;</td>
			<td style="width: 24%;">&nbsp;</td>
		</tr>
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			<td style="width: 32%; text-align: center; border-bottom: 1px solid rgb(0, 0, 0);">/s/ Morgan R. Brown</td>
			<td style="width: 1%;">&nbsp;</td>
			<td style="width: 42%; text-align: center;">Chief Financial Officer</td>
			<td style="width: 1%;">&nbsp;</td>
			<td style="width: 24%; text-align: center;">June 5, 2024</td>
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			<td style="width: 32%; text-align: center;">Morgan R. Brown</td>
			<td style="width: 1%;">&nbsp;</td>
			<td style="width: 42%; text-align: center;">(Principal Financial and Accounting Officer)</td>
			<td style="width: 1%;">&nbsp;</td>
			<td style="width: 24%; text-align: center;">&nbsp;</td>
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			<td style="width: 32%;">&nbsp;</td>
			<td style="width: 1%;">&nbsp;</td>
			<td style="width: 42%;">&nbsp;</td>
			<td style="width: 1%;">&nbsp;</td>
			<td style="width: 24%;">&nbsp;</td>
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			<td style="width: 32%; text-align: center; border-bottom: 1px solid rgb(0, 0, 0);">/s/ David J. Matlin</td>
			<td style="width: 1%;">&nbsp;</td>
			<td style="width: 42%; text-align: center;">Chairman of the Board</td>
			<td style="width: 1%;">&nbsp;</td>
			<td style="width: 24%; text-align: center;">June 5, 2024</td>
		</tr>
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			<td style="width: 32%; text-align: center;">David J. Matlin</td>
			<td style="width: 1%;">&nbsp;</td>
			<td style="width: 42%; text-align: center;">&nbsp;</td>
			<td style="width: 1%;">&nbsp;</td>
			<td style="width: 24%; text-align: center;">&nbsp;</td>
		</tr>
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			<td style="width: 32%;">&nbsp;</td>
			<td style="width: 1%;">&nbsp;</td>
			<td style="width: 42%;">&nbsp;</td>
			<td style="width: 1%;">&nbsp;</td>
			<td style="width: 24%;">&nbsp;</td>
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			<td style="width: 32%; text-align: center; border-bottom: 1px solid rgb(0, 0, 0);">/s/ Arjun Desai</td>
			<td style="width: 1%;">&nbsp;</td>
			<td style="width: 42%; text-align: center;">Director</td>
			<td style="width: 1%;">&nbsp;</td>
			<td style="width: 24%; text-align: center;">June 5, 2024</td>
		</tr>
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			<td style="width: 32%; text-align: center;">Arjun Desai</td>
			<td style="width: 1%;">&nbsp;</td>
			<td style="width: 42%; text-align: center;">&nbsp;</td>
			<td style="width: 1%;">&nbsp;</td>
			<td style="width: 24%; text-align: center;">&nbsp;</td>
		</tr>
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			<td style="width: 32%; text-align: center;">&nbsp;</td>
			<td style="width: 1%;">&nbsp;</td>
			<td style="width: 42%; text-align: center;">&nbsp;</td>
			<td style="width: 1%;">&nbsp;</td>
			<td style="width: 24%; text-align: center;">&nbsp;</td>
		</tr>
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			<td style="width: 32%; text-align: center; border-bottom: 1px solid rgb(0, 0, 0);">/s/ Jonathon T. Gay</td>
			<td style="width: 1%;">&nbsp;</td>
			<td style="width: 42%; text-align: center;">Director</td>
			<td style="width: 1%;">&nbsp;</td>
			<td style="width: 24%; text-align: center;">June 5, 2024</td>
		</tr>
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			<td style="width: 32%; text-align: center;">Jonathon T. Gay</td>
			<td style="width: 1%;">&nbsp;</td>
			<td style="width: 42%; text-align: center;">&nbsp;</td>
			<td style="width: 1%;">&nbsp;</td>
			<td style="width: 24%; text-align: center;">&nbsp;</td>
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			<td style="width: 32%;">&nbsp;</td>
			<td style="width: 1%;">&nbsp;</td>
			<td style="width: 42%;">&nbsp;</td>
			<td style="width: 1%;">&nbsp;</td>
			<td style="width: 24%;">&nbsp;</td>
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			<td style="width: 32%; text-align: center; border-bottom: 1px solid rgb(0, 0, 0);">/s/ Matthew Kiernan</td>
			<td style="width: 1%;">&nbsp;</td>
			<td style="width: 42%; text-align: center;">Director</td>
			<td style="width: 1%;">&nbsp;</td>
			<td style="width: 24%; text-align: center;">June 5, 2024</td>
		</tr>
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			<td style="width: 32%; text-align: center;">Matthew Kiernan</td>
			<td style="width: 1%;">&nbsp;</td>
			<td style="width: 42%; text-align: center;">&nbsp;</td>
			<td style="width: 1%;">&nbsp;</td>
			<td style="width: 24%; text-align: center;">&nbsp;</td>
		</tr>
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			<td style="width: 32%; text-align: center;">&nbsp;</td>
			<td style="width: 1%;">&nbsp;</td>
			<td style="width: 42%; text-align: center;">&nbsp;</td>
			<td style="width: 1%;">&nbsp;</td>
			<td style="width: 24%; text-align: center;">&nbsp;</td>
		</tr>
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			<td style="width: 32%; text-align: center; border-bottom: 1px solid rgb(0, 0, 0);">/s/ Shalom Jacobovitz</td>
			<td style="width: 1%;">&nbsp;</td>
			<td style="width: 42%; text-align: center;">Director</td>
			<td style="width: 1%;">&nbsp;</td>
			<td style="width: 24%; text-align: center;">June 5, 2024</td>
		</tr>
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			<td style="width: 32%; text-align: center;">Shalom Jacobovitz</td>
			<td style="width: 1%;">&nbsp;</td>
			<td style="width: 42%; text-align: center;">&nbsp;</td>
			<td style="width: 1%;">&nbsp;</td>
			<td style="width: 24%; text-align: center;">&nbsp;</td>
		</tr>
		<tr>
			<td style="width: 32%;">&nbsp;</td>
			<td style="width: 1%;">&nbsp;</td>
			<td style="width: 42%;">&nbsp;</td>
			<td style="width: 1%;">&nbsp;</td>
			<td style="width: 24%;">&nbsp;</td>
		</tr>
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			<td style="width: 32%; text-align: center; border-bottom: 1px solid rgb(0, 0, 0);">/s/ Vallerie V. McLaughlin</td>
			<td style="width: 1%;">&nbsp;</td>
			<td style="width: 42%; text-align: center;">Director</td>
			<td style="width: 1%;">&nbsp;</td>
			<td style="width: 24%; text-align: center;">June 5, 2024</td>
		</tr>
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			<td style="width: 32%; text-align: center;">Vallerie V. McLaughlin</td>
			<td style="width: 1%;">&nbsp;</td>
			<td style="width: 42%; text-align: center;">&nbsp;</td>
			<td style="width: 1%;">&nbsp;</td>
			<td style="width: 24%; text-align: center;">&nbsp;</td>
		</tr>
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			<td style="width: 32%;">&nbsp;</td>
			<td style="width: 1%;">&nbsp;</td>
			<td style="width: 42%;">&nbsp;</td>
			<td style="width: 1%;">&nbsp;</td>
			<td style="width: 24%;">&nbsp;</td>
		</tr>
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			<td style="width: 32%; text-align: center; border-bottom: 1px solid rgb(0, 0, 0);">/s/ Alison H. Mosca</td>
			<td style="width: 1%;">&nbsp;</td>
			<td style="width: 42%; text-align: center;">Director</td>
			<td style="width: 1%;">&nbsp;</td>
			<td style="width: 24%; text-align: center;">June 5, 2024</td>
		</tr>
		<tr>
			<td style="width: 32%; text-align: center;">Alison H. Mosca</td>
			<td style="width: 1%;">&nbsp;</td>
			<td style="width: 42%; text-align: center;">&nbsp;</td>
			<td style="width: 1%;">&nbsp;</td>
			<td style="width: 24%; text-align: center;">&nbsp;</td>
		</tr>
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			<td style="width: 32%;">&nbsp;</td>
			<td style="width: 1%;">&nbsp;</td>
			<td style="width: 42%;">&nbsp;</td>
			<td style="width: 1%;">&nbsp;</td>
			<td style="width: 24%;">&nbsp;</td>
		</tr>
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			<td style="width: 32%; text-align: center; border-bottom: 1px solid rgb(0, 0, 0);">/s/ Reed Neil Wilcox</td>
			<td style="width: 1%;">&nbsp;</td>
			<td style="width: 42%; text-align: center;">Director</td>
			<td style="width: 1%;">&nbsp;</td>
			<td style="width: 24%; text-align: center;">June 5, 2024</td>
		</tr>
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			<td style="width: 32%; text-align: center;">Reed Neil Wilcox</td>
			<td style="width: 1%;">&nbsp;</td>
			<td style="width: 42%; text-align: center;">&nbsp;</td>
			<td style="width: 1%;">&nbsp;</td>
			<td style="width: 24%; text-align: center;">&nbsp;</td>
		</tr>

</table>

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{"company-data": {"conformed-name": "Clene Inc.", "cik": "0001822791", "assigned-sic": "2834", "organization-name": "03 Life Sciences", "irs-number": "852828339", "fiscal-year-end": "1231"}, "filing-values": {"form-type": "S-8", "act": "33", "file-number": "333-279987", "film-number": "241024728"}, "business-address": {"street1": "6550 SOUTH MILLROCK DRIVE, SUITE G50", "city": "SALT LAKE CITY", "state": "UT", "zip": "84121", "phone": "801-676-9695"}, "mail-address": {"street1": "6550 SOUTH MILLROCK DRIVE, SUITE G50", "city": "SALT LAKE CITY", "state": "UT", "zip": "84121"}, "former-company": {"former-conformed-name": "Chelsea Worldwide Inc.", "date-changed": "20200827"}}
clnn20240523_s8.htm
As filed with the Securities and Exchange Commission on June 5, 2024
Registration No. 333-
UNITED STATES
SECURITIES AND EXCHANGE COMMISSION
WASHINGTON, D.C. 20549
FORM S-8
REGISTRATION STATEMENT
UNDER
THE SECURITIES ACT OF 1933
CLENE INC.
(Exact name of registrant as specified in its charter)
Delaware
85-2828339
(State or other jurisdiction
(I.R.S. Employer
of incorporation or organization)
Identification No.)
6550 South Millrock Drive, Suite G50
Salt Lake City, Utah
84121
(Address of Principal Executive Offices)
(Zip Code)
Clene Inc. Amended 2020 Stock Plan
(Full title of the plan)
Robert Etherington
President and Chief Executive Officer
6550 South Millrock Drive, Suite G50
Salt Lake City, Utah 84121
(Name and address of agent for service)
(801) 676-9695
(Telephone number, including area code, of agent for service)
Copies to:
Jerry Miraglia, Esq.
Tom McAleavey
General Counsel and Corporate Secretary
Holland & Knight LLP
6550 South Millrock Drive, Suite G50
200 South Orange Avenue, Suite 2600
Salt Lake City, Utah 84121
Orlando, Florida 32801
Tel: (801) 676-9695
Tel: (407) 244-5108
Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, a smaller reporting company or an emerging growth company. See the definitions of "large accelerated filer," "accelerated filer," "smaller reporting company," and "emerging growth company" in Rule 12b-2 of the Exchange Act:
Large accelerated filer
☐
Accelerated filer
☐
Non-accelerated filer
☒
Smaller reporting company
☒
Emerging growth company
☐
If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 7(a)(2)(B) of the Securities Act. ☐
EXPLANATORY NOTE
This registration statement on Form S-8 (the "Registration Statement") is filed by Clene Inc. (the "Company"), pursuant to General Instruction E to Form S-8 under the Securities Act of 1933, as amended, to register 30,000,000 additional shares of the Company's common stock, par value $0.0001 per share (the "Common Stock"), under the Clene Inc. Amended 2020 Stock Plan (the "2020 Stock Plan"). The amendment to increase the number of shares of Common Stock reserved for issuance under the 2020 Stock Plan from 18,400,000 to 48,400,000 was approved by the Board of Directors of the Company on April 3, 2024, and by the stockholders of the Company on May 29, 2024. This Registration Statement hereby incorporates by reference the contents of the Company's registration statement on
Form S-8 filed with the Securities and Exchange Commission on March 29, 2021 (Registration No. 333-254810)
and registration statement on
Form S-8 filed with the Securities and Exchange Commission on June 16, 2023 (Registration No. 333-272744)
, to the extent not modified or superseded hereby or by any subsequently filed document, which is incorporated by reference herein or therein.
PART II
Information Required in the Registration Statement
Item 8. Exhibits.
Exhibit Number
Exhibit Description
3.1
Fourth Amended and Restated Certificate of Incorporation of Clene Inc. (incorporated by reference to Exhibit 3.1 to the Current Report on Form 8-K filed by the Registrant on May 11, 2023).
3.2
Certificate of Amendment to the Fourth Amended and Restated Certificate of Incorporation of Clene Inc. (incorporated by reference to Exhibit 3.1 to the Current Report on Form 8-K filed by the Registrant on May 30, 2024).
3.3
Bylaws of Clene Inc. (incorporated by reference to Exhibit 3.2 to the Current Report on Form 8-K filed by the Registrant on January 5, 2021).
5.1*
Opinion of Holland & Knight LLP.
23.1*
Consent of Holland & Knight LLP (included as part of Exhibit 5.1).
23.2*
Consent of Deloitte & Touche LLP.
24.1*
Power of Attorney (included on signature page of the Registration Statement).
99.1
Clene Inc. Amended 2020 Stock Plan (incorporated by reference to Exhibit 10.1 to the Current Report on Form 8-K filed by the Registrant on May 30, 2024).
107*
Filing Fee Table.
*Filed herewith.
SIGNATURES
Pursuant to the requirements of the Securities Act of 1933, as amended, the registrant certifies that it has reasonable grounds to believe that it meets all of the requirements for filing on Form S-8 and has duly caused this Registration Statement to be signed on its behalf by the undersigned, thereunto duly authorized, in Salt Lake City, Utah, on June 5, 2024.
CLENE INC.
By:
/s/ Robert Etherington
Robert Etherington
President and Chief Executive Officer
POWER OF ATTORNEY
Each person whose signature appears below constitutes and appoints Robert Etherington attorney-in-fact, as his or her true and lawful attorney-in-fact and agent, with full power of substitution and resubstitution, for such person and in his or her name, place and stead, in any and all capacities, to sign any or all further amendments (including post-effective amendments) to this Registration Statement (and any additional registration statement related hereto permitted by Rule 462(b) promulgated under the Securities Act, (and all further amendments, including post-effective amendments, thereto)), and to file the same, with all exhibits thereto, and other documents in connection therewith, with the Securities and Exchange Commission, granting unto said attorneys-in-fact and agent full power and authority to do and perform each and every act and thing requisite and necessary to be done in and about the premises, as fully to all intents and purposes as he might or could do in person, hereby ratifying and confirming all that said attorney-in-fact and agent, or his substitute or substitutes, may lawfully do or cause to be done by virtue hereof. Pursuant to the requirements of the Securities Act of 1933, as amended, this Registration Statement has been signed by the following persons in the capacities and on the dates indicated.
Signature
Title
Date
/s/ Robert Etherington
President, Chief Executive Officer, and Director
June 5, 2024
Robert Etherington
(Principal Executive Officer)
/s/ Morgan R. Brown
Chief Financial Officer
June 5, 2024
Morgan R. Brown
(Principal Financial and Accounting Officer)
/s/ David J. Matlin
Chairman of the Board
June 5, 2024
David J. Matlin
/s/ Arjun Desai
Director
June 5, 2024
Arjun Desai
/s/ Jonathon T. Gay
Director
June 5, 2024
Jonathon T. Gay
/s/ Matthew Kiernan
Director
June 5, 2024
Matthew Kiernan
/s/ Shalom Jacobovitz
Director
June 5, 2024
Shalom Jacobovitz
/s/ Vallerie V. McLaughlin
Director
June 5, 2024
Vallerie V. McLaughlin
/s/ Alison H. Mosca
Director
June 5, 2024
Alison H. Mosca
/s/ Reed Neil Wilcox
Director
June 5, 2024
Reed Neil Wilcox