<html><head>
	<title>pbla20240104_s8.htm</title>

	<!-- Generated by ThunderDome Portal - 1/5/2024 6:39:38 PM --><meta charset="utf-8"><meta name="format-detection" content="telephone=no">
</head>
<body style="font-size: 10pt; font-family: &quot;Times New Roman&quot;; padding: 0in 0.1in; cursor: auto;">
<p style="font-family:'Times New Roman';font-size:10pt;font-variant:normal;margin:0pt;">&nbsp;</p>

<p style="font-family:Times New Roman;font-size:10pt;font-variant:normal;text-align:center;margin:0pt;"><b>As filed with the Securities and Exchange Commission on January 5, 2024.</b></p>

<p style="font-family:Times New Roman;font-size:10pt;font-variant:normal;text-align:right;margin:0pt;"><b>Registration No. </b>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</p>

<p style="font-family:Times New Roman;font-size:12pt;font-variant:normal;text-align:center;margin:0pt;"><b>UNITED STATES</b></p>

<p style="font-family:Times New Roman;font-size:12pt;font-variant:normal;text-align:center;margin:0pt;"><b>SECURITIES AND EXCHANGE COMMISSION</b></p>

<p style="font-family:Times New Roman;font-size:10pt;font-variant:normal;text-align:center;margin:0pt;"><b>Washington, D. C. 20549</b></p>

<p style="font-family:'Times New Roman';font-size:10pt;font-variant:normal;margin:0pt;">&nbsp;</p>

<p style="font-family:Times New Roman;font-size:18pt;font-variant:normal;text-align:center;margin:0pt;"><b>Form</b>&nbsp;<b>S-8</b></p>

<p style="font-family:'Times New Roman';font-size:10pt;font-variant:normal;margin:0pt;">&nbsp;</p>

<p style="font-family:Times New Roman;font-size:10pt;font-variant:normal;text-align:center;margin:0pt;"><b>REGISTRATION STATEMENT UNDER THE</b></p>

<p style="font-family:Times New Roman;font-size:10pt;font-variant:normal;text-align:center;margin:0pt;"><b>SECURITIES ACT OF 1933</b></p>

<p style="font-family:'Times New Roman';font-size:10pt;font-variant:normal;margin:0pt;">&nbsp;</p>

<table border="0" cellpadding="0" cellspacing="0" style="font-family: Times New Roman; font-size: 10pt; width: 100%;">

		<tr>
			<td style="border-bottom:solid 1px #000000;vertical-align:top;width:59.3%;">
			<p style="font-family:Times New Roman;font-size:24pt;font-variant:normal;text-align:center;margin:0pt;"><b>PANBELA THERAPEUTICS, INC.</b>&nbsp;</p>
			</td>
		</tr>
		<tr>
			<td style="vertical-align:top;width:59.3%;">
			<p style="font-family:Times New Roman;font-size:10pt;font-variant:normal;text-align:center;margin:0pt;">(Exact Name of Registrant as Specified in its Charter)</p>
			</td>
		</tr>

</table>

<p style="font-family:'Times New Roman';font-size:10pt;font-variant:normal;margin:0pt;">&nbsp;</p>

<table border="0" cellpadding="0" cellspacing="0" style="font-family:Times New Roman;font-size:10pt;width:100%;margin-left:auto;margin-right:auto;">

		<tr>
			<td style="border-bottom:solid 1px #000000;vertical-align:top;width:20.4%;">
			<p style="font-family:Times New Roman;font-size:10pt;font-variant:normal;text-align:center;margin:0pt;"><b>Delaware</b></p>
			</td>
			<td style="vertical-align:top;width:6%;">&nbsp;</td>
			<td style="border-bottom:solid 1px #000000;vertical-align:top;width:20.4%;">
			<p style="font-family:Times New Roman;font-size:10pt;font-variant:normal;text-align:center;margin:0pt;"><b>88-2805017</b></p>
			</td>
		</tr>
		<tr>
			<td style="vertical-align:top;width:20.4%;">
			<p style="font-family:Times New Roman;font-size:10pt;font-variant:normal;text-align:center;margin:0pt;">(State or other jurisdiction of<br>
			incorporation or organization)</p>
			</td>
			<td style="vertical-align:top;width:6%;">&nbsp;</td>
			<td style="vertical-align:top;width:20.4%;">
			<p style="font-family:Times New Roman;font-size:10pt;font-variant:normal;text-align:center;margin:0pt;">(I.R.S. Employer<br>
			Identification No.)</p>
			</td>
		</tr>
		<tr>
			<td style="vertical-align:bottom;width:20.4%;">&nbsp;</td>
			<td style="vertical-align:top;width:6%;">&nbsp;</td>
			<td style="vertical-align:bottom;width:20.4%;">&nbsp;</td>
		</tr>
		<tr>
			<td style="border-bottom:solid 1px #000000;vertical-align:bottom;width:20.4%;">
			<p style="font-family:Times New Roman;font-size:10pt;font-variant:normal;text-align:center;margin:0pt;"><b>712 Vista Blvd #305 </b><br>
			<b>Waconia, MN</b></p>
			</td>
			<td style="vertical-align:top;width:6%;">&nbsp;</td>
			<td style="border-bottom:solid 1px #000000;vertical-align:bottom;width:20.4%;">
			<p style="font-family:Times New Roman;font-size:10pt;font-variant:normal;text-align:center;margin:0pt;"><b>55387</b></p>
			</td>
		</tr>
		<tr>
			<td style="vertical-align:top;width:20.4%;">
			<p style="font-family:Times New Roman;font-size:10pt;font-variant:normal;text-align:center;margin:0pt;">(Address of Principal Executive Offices)</p>
			</td>
			<td style="vertical-align:top;width:6%;">&nbsp;</td>
			<td style="vertical-align:top;width:20.4%;">
			<p style="font-family:Times New Roman;font-size:10pt;font-variant:normal;text-align:center;margin:0pt;">(Zip Code)</p>
			</td>
		</tr>

</table>

<p style="font-family:'Times New Roman';font-size:10pt;font-variant:normal;margin:0pt;">&nbsp;</p>

<p style="font-family:Times New Roman;font-size:10pt;font-variant:normal;text-align:center;margin:0pt;"><b>2016 Omnibus Incentive Plan</b></p>

<p style="font-family:Times New Roman;font-size:10pt;font-variant:normal;text-align:center;margin:0pt;">(Full Title of the Plan)</p>

<p style="font-family:'Times New Roman';font-size:10pt;font-variant:normal;margin:0pt;">&nbsp;</p>

<table border="0" cellpadding="0" cellspacing="0" style="font-family:Times New Roman;font-size:10pt;width:100%;margin-left:auto;margin-right:auto;">

		<tr>
			<td style="vertical-align:top;width:3.7%;">&nbsp;</td>
			<td style="vertical-align:top;width:9.9%;">
			<p style="font-family:Times New Roman;font-size:10pt;font-variant:normal;text-align:center;margin:0pt;"><b>Susan Horvath</b></p>

			<p style="font-family:Times New Roman;font-size:10pt;font-variant:normal;text-align:center;margin:0pt;">Chief Financial Officer</p>

			<p style="font-family:Times New Roman;font-size:10pt;font-variant:normal;text-align:center;margin:0pt;">Panbela Therapeutics, Inc.</p>

			<p style="font-family:Times New Roman;font-size:10pt;font-variant:normal;text-align:center;margin:0pt;">712 Vista Blvd #305</p>

			<p style="font-family:Times New Roman;font-size:10pt;font-variant:normal;text-align:center;margin:0pt;">Waconia, MN 55387</p>

			<p style="font-family:Times New Roman;font-size:10pt;font-variant:normal;text-align:center;margin:0pt;">(Name and Address of Agent for Service)</p>
			</td>
			<td style="vertical-align:top;width:3.7%;">&nbsp;</td>
		</tr>

</table>

<p style="font-family:'Times New Roman';font-size:10pt;font-variant:normal;margin:0pt;">&nbsp;</p>

<p style="font-family:Times New Roman;font-size:10pt;font-variant:normal;text-align:center;margin:0pt;">Telephone number, including area code, of agent for service:<b> (952) 479-1196</b></p>

<p style="font-family:Times New Roman;font-size:10pt;font-variant:normal;text-align:center;margin:0pt;">&nbsp;</p>

<p style="font-family:'Times New Roman';font-size:10pt;font-variant:normal;margin:0pt;">&nbsp;</p>

<hr style="text-align: center; height: 1px; color: #000000; background-color: #000000; width: 25%; border: none; margin: 3pt auto">
<p style="font-family:'Times New Roman';font-size:10pt;font-variant:normal;margin:0pt;">&nbsp;</p>

<p style="font-family:Times New Roman;font-size:10pt;font-variant:normal;text-align:center;margin:0pt;">Copies to:</p>

<p style="font-family:Times New Roman;font-size:10pt;font-variant:normal;text-align:center;margin:0pt;"><b>W. Morgan Burns</b></p>

<p style="font-family:Times New Roman;font-size:10pt;font-variant:normal;text-align:center;margin:0pt;"><b>Joshua L. Colburn</b></p>

<p style="font-family:Times New Roman;font-size:10pt;font-variant:normal;text-align:center;margin:0pt;">Faegre Drinker Biddle &amp; Reath LLP</p>

<p style="font-family:Times New Roman;font-size:10pt;font-variant:normal;text-align:center;margin:0pt;">2200 Wells Fargo Center</p>

<p style="font-family:Times New Roman;font-size:10pt;font-variant:normal;text-align:center;margin:0pt;">90 South Seventh Street</p>

<p style="font-family:Times New Roman;font-size:10pt;font-variant:normal;text-align:center;margin:0pt;">Minneapolis, Minnesota 55402&#8209;3901</p>

<p style="font-family:'Times New Roman';font-size:10pt;font-variant:normal;margin:0pt;">&nbsp;</p>

<p style="font-family:Times New Roman;font-size:10pt;font-variant:normal;margin:0pt;">Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, a non&#8209;accelerated filer, a smaller reporting company or an emerging growth company. See the definitions of &#8220;large accelerated filer,&#8221; &#8220;accelerated filer,&#8221; &#8220;smaller reporting company,&#8221; and &#8220;emerging growth company&#8221; in Rule 12b-2 of the Exchange Act.</p>

<p style="font-family:'Times New Roman';font-size:10pt;font-variant:normal;margin:0pt;">&nbsp;</p>

<table border="0" cellpadding="0" cellspacing="0" style="font-family:Times New Roman;font-size:10pt;width:100%;margin-left:auto;margin-right:auto;">

		<tr>
			<td style="vertical-align:middle;width:32.4%;">
			<p style="font-family:Times New Roman;font-size:10pt;font-variant:normal;margin:0pt;">Large Accelerated Filer &#9744;</p>
			</td>
			<td style="vertical-align:middle;width:13.9%;">
			<p style="font-family:Times New Roman;font-size:10pt;font-variant:normal;margin:0pt;">Accelerated Filer &#9744;</p>
			</td>
		</tr>
		<tr>
			<td style="vertical-align:middle;width:32.4%;">
			<p style="font-family:Times New Roman;font-size:10pt;font-variant:normal;margin:0pt;">Non&#8209;accelerated Filer &#9745;</p>
			</td>
			<td style="vertical-align:middle;width:13.9%;">
			<p style="font-family:Times New Roman;font-size:10pt;font-variant:normal;margin:0pt;">Smaller Reporting Company &#9745;</p>
			</td>
		</tr>
		<tr>
			<td style="vertical-align:middle;width:32.4%;">&nbsp;</td>
			<td style="vertical-align:middle;width:13.9%;">
			<p style="font-family:Times New Roman;font-size:10pt;font-variant:normal;margin:0pt;">Emerging Growth Company&nbsp;&#9744;</p>
			</td>
		</tr>

</table>

<p style="font-family:Times New Roman;font-size:10pt;font-variant:normal;margin:0pt;">&nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp;</p>

<p style="font-family:Times New Roman;font-size:10pt;font-variant:normal;margin:0pt;">If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 7(a)(2)(B) of the Securities Act. &#9744;</p>

<p style="font-family:'Times New Roman';font-size:10pt;font-variant:normal;margin:0pt;">&nbsp;</p>

<p style="font-family:'Times New Roman';font-size:10pt;font-variant:normal;margin:0pt;">&nbsp;</p>

<div class="PGBK" style="width: 100%; margin-left: 0pt; margin-right: 0pt">
<div class="PGNUM" style="text-align: center; width: 100%">&nbsp;</div>

<hr style="PAGE-BREAK-AFTER: always; border: none; width: 100%; height: 2px; color: #000000; background-color: #000000">
<div class="PGHDR" style="text-align: left; width: 100%">&nbsp;</div>
</div>

<p style="font-family:'Times New Roman';font-size:10pt;font-variant:normal;margin:0pt;">&nbsp;</p>

<p style="font-family:Times New Roman;font-size:10pt;font-variant:normal;text-align:center;margin:0pt;"><b>PANBELA THERAPEUTICS, INC.</b></p>

<p style="font-family:'Times New Roman';font-size:10pt;font-variant:normal;margin:0pt;">&nbsp;</p>

<p style="font-family:Times New Roman;font-size:10pt;font-variant:normal;text-align:center;margin:0pt;"><b>STATEMENT PURSUANT TO GENERAL INSTRUCTION E</b><br>
<b>TO FORM S-8 </b>&#8220;<b>REGISTRATION OF ADDITIONAL SECURITIES</b>&#8221;</p>

<p style="font-family:'Times New Roman';font-size:10pt;font-variant:normal;margin:0pt;">&nbsp;</p>

<p style="font-family:Times New Roman;font-size:10pt;font-variant:normal;text-align:justify;margin:0pt;">The stockholders of Panbela Therapeutics, Inc., (the &#8220;Company&#8221;) initially approved the Company&#8217;s 2016 Omnibus Incentive Plan on May&nbsp;17, 2016. On May 19, 2020, the stockholders of the Company approved an amendment and restatement of the Company&#8217;s 2016 Omnibus Incentive Plan (as amended and restated, the &#8220;2016 Plan&#8221;). The 2016 Plan provides, among other things, that the number of shares of the Company&#8217;s common stock available for issuance under the plan will increase on January 1 of each year beginning in 2021 and ending on January 1, 2025 in an amount equal to the lesser of (i) the number of shares necessary to increase the total option pool to 20% of the total number of fully diluted shares (as defined in the 2016 Plan) as of December 31 of the immediately preceding calendar year and (ii) such lesser number of shares as may be determined by the Company&#8217;s Board of Directors or its Compensation Committee prior to January 1st of any calendar year.</p>

<p style="font-family:'Times New Roman';font-size:10pt;font-variant:normal;margin:0pt;">&nbsp;</p>

<p style="font-family:Times New Roman;font-size:10pt;font-variant:normal;text-align:justify;margin:0pt;">Pursuant to General Instruction E to Form S-8, the contents of the Initial Registration Statement, together with all exhibits filed therewith or incorporated therein by reference, are incorporated herein by reference.</p>

<p style="font-family:'Times New Roman';font-size:10pt;font-variant:normal;margin:0pt;">&nbsp;</p>

<p style="font-family:Times New Roman;font-size:10pt;font-variant:normal;text-align:justify;margin:0pt;">The Company has filed this registration statement on Form S-8 to register the 3,275,155 additional shares of Common Stock, not previously registered under the 2016 Plan, that became available for issuance under the 2016 Plan effective as of January&nbsp;1, 2024.</p>

<p style="font-family:'Times New Roman';font-size:10pt;font-variant:normal;margin:0pt;">&nbsp;</p>

<p style="font-family:Times New Roman;font-size:10pt;font-variant:normal;text-align:center;margin:0pt;"><b>PART II</b></p>

<p style="font-family:'Times New Roman';font-size:10pt;font-variant:normal;margin:0pt;">&nbsp;</p>

<p style="font-family:Times New Roman;font-size:10pt;font-variant:normal;text-align:center;margin:0pt;"><b>INFORMATION REQUIRED IN THE REGISTRATION STATEMENT</b></p>

<p style="font-family:'Times New Roman';font-size:10pt;font-variant:normal;margin:0pt;">&nbsp;</p>

<p style="font-family:Times New Roman;font-size:10pt;font-variant:normal;margin:0pt;"><b>Item 8.</b>&nbsp;&nbsp;&nbsp;&nbsp;<b>Exhibits.</b></p>

<p style="font-family:'Times New Roman';font-size:10pt;font-variant:normal;margin:0pt;">&nbsp;</p>

<table border="0" cellpadding="0" cellspacing="0" style="font-family:Times New Roman;font-size:10pt;width:100%;margin-left:auto;margin-right:auto;">

		<tr>
			<td style="border-bottom:solid 1px #000000;vertical-align:bottom;width:3.2%;">
			<p style="font-family:Times New Roman;font-size:10pt;font-variant:normal;text-align:center;margin:0pt;"><b>Exhibit</b></p>

			<p style="font-family:Times New Roman;font-size:10pt;font-variant:normal;text-align:center;margin:0pt;"><b>Number</b></p>
			</td>
			<td style="vertical-align:bottom;width:0.5%;">&nbsp;</td>
			<td style="border-bottom:solid 1px #000000;vertical-align:bottom;width:42.6%;">
			<p style="font-family:Times New Roman;font-size:10pt;font-variant:normal;text-align:center;margin:0pt;"><b>Description of Exhibit</b></p>
			</td>
		</tr>
		<tr>
			<td style="vertical-align:top;width:3.2%;">
			<p style="font-family:Times New Roman;font-size:10pt;font-variant:normal;text-align:center;margin:0pt;">4.1</p>
			</td>
			<td style="vertical-align:top;width:0.5%;">&nbsp;</td>
			<td style="vertical-align:top;width:42.6%;">
			<p style="font-family:Times New Roman;font-size:10pt;font-variant:normal;margin:0pt;"><a href="http://www.sec.gov/Archives/edgar/data/1029125/000143774923001167/ex_464424.htm" style="-sec-extract:exhibit;"><u>Restated Certificate of Incorporation (incorporated by reference to Exhibit 3.1 to current report on Form 8-K filed January 17, 2023).</u><u>&nbsp;</u></a></p>
			</td>
		</tr>
		<tr>
			<td style="vertical-align:top;width:3.2%;">
			<p style="font-family:Times New Roman;font-size:10pt;font-variant:normal;text-align:center;margin:0pt;">4.2</p>
			</td>
			<td style="vertical-align:top;width:0.5%;">&nbsp;</td>
			<td style="vertical-align:top;width:42.6%;">
			<p style="font-family:Times New Roman;font-size:10pt;font-variant:normal;margin:0pt;"><a href="http://www.sec.gov/Archives/edgar/data/1029125/000143774923016196/ex_527861.htm" style="-sec-extract:exhibit;">Certificate of Amendment to Restated Certificate of Incorporation (incorporated by reference to Exhibit 3.1 to current report on Form 8-K filed May 31, 2023)</a></p>
			</td>
		</tr>
		<tr>
			<td style="vertical-align:top;width:3.2%;">
			<p style="font-family:Times New Roman;font-size:10pt;font-variant:normal;text-align:center;margin:0pt;">4.3</p>
			</td>
			<td style="vertical-align:top;width:0.5%;">&nbsp;</td>
			<td style="vertical-align:top;width:42.6%;">
			<p style="font-family:Times New Roman;font-size:10pt;font-variant:normal;margin:0pt;"><a href="http://www.sec.gov/Archives/edgar/data/1029125/000143774923010553/ex_501510.htm" style="-sec-extract:exhibit;">Amended and Restated Bylaws (incorporated by reference to Exhibit 3.1 to current report on Form 8-K filed April 18, 2023).</a></p>
			</td>
		</tr>
		<tr>
			<td style="vertical-align:top;width:3.2%;">
			<p style="font-family:Times New Roman;font-size:10pt;font-variant:normal;text-align:center;margin:0pt;">5.1+</p>
			</td>
			<td style="vertical-align:top;width:0.5%;">&nbsp;</td>
			<td style="vertical-align:top;width:42.6%;">
			<p style="font-family:Times New Roman;font-size:10pt;font-variant:normal;margin:0pt;"><a href="ex_612632.htm" style="-sec-extract:exhibit;"><u>Opinion of Faegre Drinker Biddle &amp; Reath LLP</u></a></p>
			</td>
		</tr>
		<tr>
			<td style="vertical-align:top;width:3.2%;">
			<p style="font-family:Times New Roman;font-size:10pt;font-variant:normal;text-align:center;margin:0pt;">23.1+</p>
			</td>
			<td style="vertical-align:top;width:0.5%;">&nbsp;</td>
			<td style="vertical-align:top;width:42.6%;">
			<p style="font-family:Times New Roman;font-size:10pt;font-variant:normal;margin:0pt;"><a href="ex_612384.htm" style="-sec-extract:exhibit;"><u>Consent of Independent Registered Public Accounting Firm (Cherry Bekaert LLP)</u></a></p>
			</td>
		</tr>
		<tr>
			<td style="vertical-align:top;width:3.2%;">
			<p style="font-family:Times New Roman;font-size:10pt;font-variant:normal;text-align:center;margin:0pt;">23.2+</p>
			</td>
			<td style="vertical-align:top;width:0.5%;">&nbsp;</td>
			<td style="vertical-align:top;width:42.6%;">
			<p style="font-family:Times New Roman;font-size:10pt;font-variant:normal;margin:0pt;"><a href="ex_612632.htm" style="-sec-extract:exhibit;"><u>Consent of Faegre Drinker Biddle &amp; Reath LLP (included in Exhibit 5.1)</u></a></p>
			</td>
		</tr>
		<tr>
			<td style="vertical-align:top;width:3.2%;">
			<p style="font-family:Times New Roman;font-size:10pt;font-variant:normal;text-align:center;margin:0pt;">24</p>
			</td>
			<td style="vertical-align:top;width:0.5%;">&nbsp;</td>
			<td style="vertical-align:top;width:42.6%;">
			<p style="font-family:Times New Roman;font-size:10pt;font-variant:normal;margin:0pt;"><a href="#pooa" style="-sec-extract:exhibit;"><u>Powers of Attorney (included with signatures)</u></a></p>
			</td>
		</tr>
		<tr>
			<td style="vertical-align:top;width:3.2%;">
			<p style="font-family:Times New Roman;font-size:10pt;font-variant:normal;text-align:center;margin:0pt;">99.1</p>
			</td>
			<td style="vertical-align:top;width:0.5%;">&nbsp;</td>
			<td style="vertical-align:top;width:42.6%;">
			<p style="font-family:Times New Roman;font-size:10pt;font-variant:normal;margin:0pt;"><a href="http://www.sec.gov/Archives/edgar/data/1029125/000143774920011719/ex_187936.htm" style="-sec-extract:exhibit;"><u>2016 Omnibus Incentive Plan (incorporated by reference to Exhibit 99.1 to current report on Form 8-K filed May 26, 2020)</u></a></p>
			</td>
		</tr>
		<tr>
			<td style="vertical-align:top;width:3.2%;">
			<p style="font-family:Times New Roman;font-size:10pt;font-variant:normal;text-align:center;margin:0pt;">107+</p>
			</td>
			<td style="vertical-align:top;width:0.5%;">&nbsp;</td>
			<td style="vertical-align:top;width:42.6%;">
			<p style="font-family:Times New Roman;font-size:10pt;font-variant:normal;margin:0pt;"><a href="ex_612385.htm" style="-sec-extract:exhibit;"><u>Filing Fee Table</u></a></p>
			</td>
		</tr>

</table>

<p style="font-family:'Times New Roman';font-size:10pt;font-variant:normal;margin:0pt;">&nbsp;</p>

<hr style="text-align: left; height: 1px; color: #000000; background-color: #000000; width: 10%; border: none; margin: 3pt auto 3pt 0">
<p style="font-size: 10pt; font-family: &quot;Times New Roman&quot;; margin: 0pt;">+ Filed herewith</p>

<p style="font-family:'Times New Roman';font-size:10pt;font-variant:normal;margin:0pt;">&nbsp;</p>

<p style="font-family:'Times New Roman';font-size:10pt;font-variant:normal;margin:0pt;">&nbsp;</p>

<div class="PGBK" style="width: 100%; margin-left: 0pt; margin-right: 0pt">
<div class="PGNUM" style="text-align: center; width: 100%">&nbsp;</div>

<hr style="PAGE-BREAK-AFTER: always; border: none; width: 100%; height: 2px; color: #000000; background-color: #000000">
<div class="PGHDR" style="text-align: left; width: 100%">&nbsp;</div>
</div>

<p style="font-family:'Times New Roman';font-size:10pt;font-variant:normal;margin:0pt;">&nbsp;</p>

<p style="font-family:'Times New Roman';font-size:10pt;font-variant:normal;margin:0pt;">&nbsp;</p>

<p style="font-family:Times New Roman;font-size:10pt;font-variant:normal;text-align:center;margin:0pt;"><b>SIGNATURES</b></p>

<p style="font-family:'Times New Roman';font-size:10pt;font-variant:normal;margin:0pt;">&nbsp;</p>

<p style="font-family:Times New Roman;font-size:10pt;font-variant:normal;margin:0pt;">Pursuant to the requirements of the Securities Act of 1933, the Registrant certifies that it has reasonable grounds to believe that it meets all of the requirements for filing on Form S&#8209;8 and has duly caused this Registration Statement to be signed on its behalf by the undersigned, thereunto duly authorized, in the City of Minneapolis, State of Minnesota, on January 5, 2024.</p>

<p style="font-family:'Times New Roman';font-size:10pt;font-variant:normal;margin:0pt;">&nbsp;</p>

<table border="0" cellpadding="0" cellspacing="0" style="font-family:Times New Roman;font-size:10pt;width:50%;margin-left:auto;margin-right:0pt;">

		<tr>
			<td style="vertical-align:middle;width:7.6%;">&nbsp;</td>
			<td style="vertical-align:bottom;width:1.1%;">&nbsp;</td>
			<td style="vertical-align:middle;width:90.2%;">&nbsp;</td>
		</tr>
		<tr>
			<td colspan="3" style="vertical-align:top;width:auto;">
			<p style="font-family:Times New Roman;font-size:10pt;font-variant:normal;margin:0pt;"><b>PANBELA THERAPEUTICS, INC.</b></p>
			</td>
		</tr>
		<tr>
			<td style="vertical-align:middle;width:auto;">&nbsp;</td>
			<td colspan="2" style="vertical-align:middle;width:auto;">&nbsp;</td>
		</tr>
		<tr>
			<td style="vertical-align:top;width:auto;">
			<p style="font-family:Times New Roman;font-size:10pt;font-variant:normal;margin:0pt;">By:</p>
			</td>
			<td style="vertical-align:bottom;width:auto;">&nbsp;</td>
			<td style="border-bottom:solid 1px #000000;vertical-align:bottom;width:auto;">
			<p style="font-family:Times New Roman;font-size:10pt;font-variant:normal;margin:0pt;">/s/ Jennifer K. Simpson</p>
			</td>
		</tr>
		<tr>
			<td style="vertical-align:top;width:auto;">&nbsp;</td>
			<td style="vertical-align:bottom;width:auto;">&nbsp;</td>
			<td style="vertical-align:bottom;width:auto;">
			<p style="font-family:Times New Roman;font-size:10pt;font-variant:normal;margin:0pt;">Name: Jennifer K. Simpson</p>
			</td>
		</tr>
		<tr>
			<td style="vertical-align:top;width:auto;">&nbsp;</td>
			<td style="vertical-align:bottom;width:auto;">&nbsp;</td>
			<td style="vertical-align:bottom;width:auto;">
			<p style="font-family:Times New Roman;font-size:10pt;font-variant:normal;margin:0pt;">Title: President and Chief Executive Officer</p>
			</td>
		</tr>

</table>

<p style="font-family:'Times New Roman';font-size:10pt;font-variant:normal;margin:0pt;">&nbsp;</p>

<p style="font-family:Times New Roman;font-size:10pt;font-variant:normal;text-align:center;margin:0pt;"><b><a id="pooa" name="pooa" title="pooa"></a>POWER OF ATTORNEY</b></p>

<p style="font-family:'Times New Roman';font-size:10pt;font-variant:normal;margin:0pt;">&nbsp;</p>

<p style="font-family:Times New Roman;font-size:10pt;font-variant:normal;margin:0pt;">Each person whose signature appears below hereby constitutes and appoints Jennifer K. Simpson and Susan Horvath, and each of them acting individually, as his or her true and lawful attorneys-in-fact and agents, with full power of each to act alone, with full powers of substitution and resubstitution, for him and in his name, place and stead, in any and all capacities, to sign the Registration Statement filed herewith and any and all amendments to said Registration Statement (including post-effective amendments), and file the same, with all exhibits thereto, and other documents in connection therewith, with the Securities and Exchange Commission, granting unto said attorneys-in-fact and agents, with full power of each to act alone, full power and authority to do and perform each and every act and thing requisite and necessary to be done in connection therewith, as fully for all intents and purposes as he might or could do in person, hereby ratifying and confirming all that said attorneys-in-fact and agents, or his or their substitutes, may lawfully do or cause to be done by virtue hereof.</p>

<p style="font-family:'Times New Roman';font-size:10pt;font-variant:normal;margin:0pt;">&nbsp;</p>

<p style="font-family:Times New Roman;font-size:10pt;font-variant:normal;margin:0pt;">Pursuant to the requirements of the Securities Act of 1933, as amended, this Registration Statement has been signed below by the following persons on behalf of the Registrant and in the capacities indicated on January 5, 2024:</p>

<p style="font-family:'Times New Roman';font-size:10pt;font-variant:normal;margin:0pt;">&nbsp;</p>

<table border="0" cellpadding="0" cellspacing="0" style="font-family:Times New Roman;font-size:10pt;width:100%;margin-left:auto;margin-right:auto;">

		<tr>
			<td style="border-bottom:solid 1px #000000;vertical-align:top;width:14.3%;">
			<p style="font-family:Times New Roman;font-size:10pt;font-variant:normal;text-align:center;margin:0pt;"><b>Signature</b></p>
			</td>
			<td style="vertical-align:top;width:1.4%;">&nbsp;</td>
			<td style="border-bottom:solid 1px #000000;vertical-align:top;width:30.5%;">
			<p style="font-family:Times New Roman;font-size:10pt;font-variant:normal;text-align:center;margin:0pt;"><b>Title</b></p>
			</td>
		</tr>
		<tr>
			<td style="vertical-align:top;width:14.3%;">&nbsp;</td>
			<td style="vertical-align:top;width:1.4%;">&nbsp;</td>
			<td style="vertical-align:top;width:30.5%;">&nbsp;</td>
		</tr>
		<tr>
			<td style="border-bottom:solid 1px #000000;vertical-align:bottom;width:14.3%;">
			<p style="font-family:Times New Roman;font-size:10pt;font-variant:normal;margin:0pt;">/s/ Jennifer K. Simpson</p>
			</td>
			<td style="vertical-align:top;width:1.4%;">&nbsp;</td>
			<td style="vertical-align:bottom;width:30.5%;">
			<p style="font-family:Times New Roman;font-size:10pt;font-variant:normal;margin:0pt;">President and Chief Executive Officer</p>
			</td>
		</tr>
		<tr>
			<td style="vertical-align:top;width:14.3%;">
			<p style="font-family:Times New Roman;font-size:10pt;font-variant:normal;margin:0pt;">Jennifer K. Simpson</p>
			</td>
			<td style="vertical-align:top;width:1.4%;">&nbsp;</td>
			<td style="vertical-align:top;width:30.5%;">
			<p style="font-family:Times New Roman;font-size:10pt;font-variant:normal;margin:0pt;">(<i>principal executive officer</i>)</p>
			</td>
		</tr>
		<tr>
			<td style="vertical-align:top;width:14.3%;">&nbsp;</td>
			<td style="vertical-align:top;width:1.4%;">&nbsp;</td>
			<td style="vertical-align:top;width:30.5%;">&nbsp;</td>
		</tr>
		<tr>
			<td style="border-bottom:solid 1px #000000;vertical-align:bottom;width:14.3%;">
			<p style="font-family:Times New Roman;font-size:10pt;font-variant:normal;margin:0pt;">/s/ Susan Horvath</p>
			</td>
			<td style="vertical-align:top;width:1.4%;">&nbsp;</td>
			<td style="vertical-align:bottom;width:30.5%;">
			<p style="font-family:Times New Roman;font-size:10pt;font-variant:normal;margin:0pt;">Vice President of Finance, Chief Financial Officer, Treasurer and Secretary</p>
			</td>
		</tr>
		<tr>
			<td style="vertical-align:top;width:14.3%;">
			<p style="font-family:Times New Roman;font-size:10pt;font-variant:normal;margin:0pt;">Susan Horvath</p>
			</td>
			<td style="vertical-align:top;width:1.4%;">&nbsp;</td>
			<td style="vertical-align:top;width:30.5%;">
			<p style="font-family:Times New Roman;font-size:10pt;font-variant:normal;margin:0pt;">(<i>principal financial and accounting officer</i>)</p>
			</td>
		</tr>
		<tr>
			<td style="vertical-align:bottom;width:14.3%;">&nbsp;</td>
			<td style="vertical-align:top;width:1.4%;">&nbsp;</td>
			<td style="vertical-align:bottom;width:30.5%;">&nbsp;</td>
		</tr>
		<tr>
			<td style="border-bottom:solid 1px #000000;vertical-align:bottom;width:14.3%;">
			<p style="font-family:Times New Roman;font-size:10pt;font-variant:normal;margin:0pt;">/s/ Michael T. Cullen</p>
			</td>
			<td style="vertical-align:top;width:1.4%;">&nbsp;</td>
			<td style="vertical-align:bottom;width:30.5%;">
			<p style="font-family:Times New Roman;font-size:10pt;font-variant:normal;margin:0pt;">Executive Chairman and Director</p>
			</td>
		</tr>
		<tr>
			<td style="vertical-align:top;width:14.3%;">
			<p style="font-family:Times New Roman;font-size:10pt;font-variant:normal;margin:0pt;">Michael T. Cullen</p>
			</td>
			<td style="vertical-align:top;width:1.4%;">&nbsp;</td>
			<td style="vertical-align:top;width:30.5%;">&nbsp;</td>
		</tr>
		<tr>
			<td style="vertical-align:top;width:14.3%;">&nbsp;</td>
			<td style="vertical-align:top;width:1.4%;">&nbsp;</td>
			<td style="vertical-align:top;width:30.5%;">&nbsp;</td>
		</tr>
		<tr>
			<td style="border-bottom:solid 1px #000000;vertical-align:bottom;width:14.3%;">
			<p style="font-family:Times New Roman;font-size:10pt;font-variant:normal;margin:0pt;">/s/ Daniel J. Donovan</p>
			</td>
			<td style="vertical-align:top;width:1.4%;">&nbsp;</td>
			<td style="vertical-align:top;width:30.5%;">
			<p style="font-family:Times New Roman;font-size:10pt;font-variant:normal;margin:0pt;">Director</p>
			</td>
		</tr>
		<tr>
			<td style="vertical-align:top;width:14.3%;">
			<p style="font-family:Times New Roman;font-size:10pt;font-variant:normal;margin:0pt;">Daniel J. Donovan</p>
			</td>
			<td style="vertical-align:top;width:1.4%;">&nbsp;</td>
			<td style="vertical-align:top;width:30.5%;">&nbsp;</td>
		</tr>
		<tr>
			<td style="vertical-align:top;width:14.3%;">&nbsp;</td>
			<td style="vertical-align:top;width:1.4%;">&nbsp;</td>
			<td style="vertical-align:top;width:30.5%;">&nbsp;</td>
		</tr>
		<tr>
			<td style="border-bottom:solid 1px #000000;vertical-align:top;width:14.3%;">
			<p style="font-family:Times New Roman;font-size:10pt;font-variant:normal;margin:0pt;">/s/ Arthur J. Fratamico</p>
			</td>
			<td style="vertical-align:top;width:1.4%;">&nbsp;</td>
			<td style="vertical-align:bottom;width:30.5%;">
			<p style="font-family:Times New Roman;font-size:10pt;font-variant:normal;margin:0pt;">Director</p>
			</td>
		</tr>
		<tr>
			<td style="vertical-align:top;width:14.3%;">
			<p style="font-family:Times New Roman;font-size:10pt;font-variant:normal;margin:0pt;">Arthur J. Fratamico</p>
			</td>
			<td style="vertical-align:top;width:1.4%;">&nbsp;</td>
			<td style="vertical-align:top;width:30.5%;">&nbsp;</td>
		</tr>
		<tr>
			<td style="vertical-align:top;width:14.3%;">&nbsp;</td>
			<td style="vertical-align:top;width:1.4%;">&nbsp;</td>
			<td style="vertical-align:top;width:30.5%;">&nbsp;</td>
		</tr>
		<tr>
			<td style="border-bottom:solid 1px #000000;vertical-align:top;width:14.3%;">
			<p style="font-family:Times New Roman;font-size:10pt;font-variant:normal;margin:0pt;">/s/ Jeffrey E. Jacob</p>
			</td>
			<td style="vertical-align:top;width:1.4%;">&nbsp;</td>
			<td style="vertical-align:top;width:30.5%;">
			<p style="font-family:Times New Roman;font-size:10pt;font-variant:normal;margin:0pt;">Director</p>
			</td>
		</tr>
		<tr>
			<td style="vertical-align:top;width:14.3%;">
			<p style="font-family:Times New Roman;font-size:10pt;font-variant:normal;margin:0pt;">Jeffrey E. Jacob</p>
			</td>
			<td style="vertical-align:top;width:1.4%;">&nbsp;</td>
			<td style="vertical-align:top;width:30.5%;">&nbsp;</td>
		</tr>
		<tr>
			<td style="vertical-align:top;width:14.3%;">&nbsp;</td>
			<td style="vertical-align:top;width:1.4%;">&nbsp;</td>
			<td style="vertical-align:top;width:30.5%;">&nbsp;</td>
		</tr>
		<tr>
			<td style="border-bottom:solid 1px #000000;vertical-align:top;width:14.3%;">
			<p style="font-family:Times New Roman;font-size:10pt;font-variant:normal;margin:0pt;">/s/ Jeffrey S. Mathiesen</p>
			</td>
			<td style="vertical-align:top;width:1.4%;">&nbsp;</td>
			<td style="vertical-align:top;width:30.5%;">
			<p style="font-family:Times New Roman;font-size:10pt;font-variant:normal;margin:0pt;">Director</p>
			</td>
		</tr>
		<tr>
			<td style="vertical-align:top;width:14.3%;">
			<p style="font-family:Times New Roman;font-size:10pt;font-variant:normal;margin:0pt;">Jeffrey S. Mathiesen</p>
			</td>
			<td style="vertical-align:top;width:1.4%;">&nbsp;</td>
			<td style="vertical-align:top;width:30.5%;">&nbsp;</td>
		</tr>
		<tr>
			<td style="vertical-align:top;width:14.3%;">&nbsp;</td>
			<td style="vertical-align:top;width:1.4%;">&nbsp;</td>
			<td style="vertical-align:top;width:30.5%;">&nbsp;</td>
		</tr>
		<tr>
			<td style="border-bottom:solid 1px #000000;vertical-align:top;width:14.3%;">
			<p style="font-family:Times New Roman;font-size:10pt;font-variant:normal;margin:0pt;">/s/ D. Robert Schemel</p>
			</td>
			<td style="vertical-align:top;width:1.4%;">&nbsp;</td>
			<td style="vertical-align:top;width:30.5%;">
			<p style="font-family:Times New Roman;font-size:10pt;font-variant:normal;margin:0pt;">Director</p>
			</td>
		</tr>
		<tr>
			<td style="vertical-align:top;width:14.3%;">
			<p style="font-family:Times New Roman;font-size:10pt;font-variant:normal;margin:0pt;">D. Robert Schemel</p>
			</td>
			<td style="vertical-align:top;width:1.4%;">&nbsp;</td>
			<td style="vertical-align:top;width:30.5%;">&nbsp;</td>
		</tr>

</table>

<p style="font-family:'Times New Roman';font-size:10pt;font-variant:normal;margin:0pt;">&nbsp;</p>

<div class="LAST-PAGE-BREAK">
<div class="PGFTR">
<div class="hf-row">
<div class="hf-cell PGNUM">&nbsp;</div>
</div>
</div>
</div>


</body></html>
[{"type": "S-8", "sequence": "1", "filename": "pbla20240104_s8.htm", "description": "FORM S-8", "secsgml_size_bytes": 35577}]
{"company-data": {"conformed-name": "Panbela Therapeutics, Inc.", "cik": "0001029125", "assigned-sic": "2834", "organization-name": "03 Life Sciences", "irs-number": "870543922", "state-of-incorporation": "DE", "fiscal-year-end": "1231"}, "filing-values": {"form-type": "S-8", "act": "33", "file-number": "333-276405", "film-number": "24516747"}, "business-address": {"street1": "712 VISTA BLVD #305", "city": "WACONIA", "state": "MN", "zip": "55387", "phone": "9524791196"}, "mail-address": {"street1": "712 VISTA BLVD #305", "city": "WACONIA", "state": "MN", "zip": "55387"}, "former-company": [{"former-conformed-name": "Sun BioPharma, Inc.", "date-changed": "20150911"}, {"former-conformed-name": "Cimarron Medical, Inc.", "date-changed": "20150602"}, {"former-conformed-name": "CIMARRON SOFTWARE INC", "date-changed": "19961217"}]}
pbla20240104_s8.htm
As filed with the Securities and Exchange Commission on January 5, 2024.
Registration No.
UNITED STATES
SECURITIES AND EXCHANGE COMMISSION
Washington, D. C. 20549
Form
S-8
REGISTRATION STATEMENT UNDER THE
SECURITIES ACT OF 1933
PANBELA THERAPEUTICS, INC.
(Exact Name of Registrant as Specified in its Charter)
Delaware
88-2805017
(State or other jurisdiction of
incorporation or organization)
(I.R.S. Employer
Identification No.)
712 Vista Blvd #305
Waconia, MN
55387
(Address of Principal Executive Offices)
(Zip Code)
2016 Omnibus Incentive Plan
(Full Title of the Plan)
Susan Horvath
Chief Financial Officer
Panbela Therapeutics, Inc.
712 Vista Blvd #305
Waconia, MN 55387
(Name and Address of Agent for Service)
Telephone number, including area code, of agent for service:
(952) 479-1196
Copies to:
W. Morgan Burns
Joshua L. Colburn
Faegre Drinker Biddle & Reath LLP
2200 Wells Fargo Center
90 South Seventh Street
Minneapolis, Minnesota 55402‑3901
Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, a non‑accelerated filer, a smaller reporting company or an emerging growth company. See the definitions of "large accelerated filer," "accelerated filer," "smaller reporting company," and "emerging growth company" in Rule 12b-2 of the Exchange Act.
Large Accelerated Filer ☐
Accelerated Filer ☐
Non‑accelerated Filer ☑
Smaller Reporting Company ☑
Emerging Growth Company ☐
If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 7(a)(2)(B) of the Securities Act. ☐
PANBELA THERAPEUTICS, INC.
STATEMENT PURSUANT TO GENERAL INSTRUCTION E
TO FORM S-8
"
REGISTRATION OF ADDITIONAL SECURITIES
"
The stockholders of Panbela Therapeutics, Inc., (the "Company") initially approved the Company's 2016 Omnibus Incentive Plan on May 17, 2016. On May 19, 2020, the stockholders of the Company approved an amendment and restatement of the Company's 2016 Omnibus Incentive Plan (as amended and restated, the "2016 Plan"). The 2016 Plan provides, among other things, that the number of shares of the Company's common stock available for issuance under the plan will increase on January 1 of each year beginning in 2021 and ending on January 1, 2025 in an amount equal to the lesser of (i) the number of shares necessary to increase the total option pool to 20% of the total number of fully diluted shares (as defined in the 2016 Plan) as of December 31 of the immediately preceding calendar year and (ii) such lesser number of shares as may be determined by the Company's Board of Directors or its Compensation Committee prior to January 1st of any calendar year.
Pursuant to General Instruction E to Form S-8, the contents of the Initial Registration Statement, together with all exhibits filed therewith or incorporated therein by reference, are incorporated herein by reference.
The Company has filed this registration statement on Form S-8 to register the 3,275,155 additional shares of Common Stock, not previously registered under the 2016 Plan, that became available for issuance under the 2016 Plan effective as of January 1, 2024.
PART II
INFORMATION REQUIRED IN THE REGISTRATION STATEMENT
Item 8.
Exhibits.
Exhibit
Number
Description of Exhibit
4.1
Restated Certificate of Incorporation (incorporated by reference to Exhibit 3.1 to current report on Form 8-K filed January 17, 2023).
4.2
Certificate of Amendment to Restated Certificate of Incorporation (incorporated by reference to Exhibit 3.1 to current report on Form 8-K filed May 31, 2023)
4.3
Amended and Restated Bylaws (incorporated by reference to Exhibit 3.1 to current report on Form 8-K filed April 18, 2023).
5.1+
Opinion of Faegre Drinker Biddle & Reath LLP
23.1+
Consent of Independent Registered Public Accounting Firm (Cherry Bekaert LLP)
23.2+
Consent of Faegre Drinker Biddle & Reath LLP (included in Exhibit 5.1)
24
Powers of Attorney (included with signatures)
99.1
2016 Omnibus Incentive Plan (incorporated by reference to Exhibit 99.1 to current report on Form 8-K filed May 26, 2020)
107+
Filing Fee Table
+ Filed herewith
SIGNATURES
Pursuant to the requirements of the Securities Act of 1933, the Registrant certifies that it has reasonable grounds to believe that it meets all of the requirements for filing on Form S‑8 and has duly caused this Registration Statement to be signed on its behalf by the undersigned, thereunto duly authorized, in the City of Minneapolis, State of Minnesota, on January 5, 2024.
PANBELA THERAPEUTICS, INC.
By:
/s/ Jennifer K. Simpson
Name: Jennifer K. Simpson
Title: President and Chief Executive Officer
POWER OF ATTORNEY
Each person whose signature appears below hereby constitutes and appoints Jennifer K. Simpson and Susan Horvath, and each of them acting individually, as his or her true and lawful attorneys-in-fact and agents, with full power of each to act alone, with full powers of substitution and resubstitution, for him and in his name, place and stead, in any and all capacities, to sign the Registration Statement filed herewith and any and all amendments to said Registration Statement (including post-effective amendments), and file the same, with all exhibits thereto, and other documents in connection therewith, with the Securities and Exchange Commission, granting unto said attorneys-in-fact and agents, with full power of each to act alone, full power and authority to do and perform each and every act and thing requisite and necessary to be done in connection therewith, as fully for all intents and purposes as he might or could do in person, hereby ratifying and confirming all that said attorneys-in-fact and agents, or his or their substitutes, may lawfully do or cause to be done by virtue hereof.
Pursuant to the requirements of the Securities Act of 1933, as amended, this Registration Statement has been signed below by the following persons on behalf of the Registrant and in the capacities indicated on January 5, 2024:
Signature
Title
/s/ Jennifer K. Simpson
President and Chief Executive Officer
Jennifer K. Simpson
(
principal executive officer
)
/s/ Susan Horvath
Vice President of Finance, Chief Financial Officer, Treasurer and Secretary
Susan Horvath
(
principal financial and accounting officer
)
/s/ Michael T. Cullen
Executive Chairman and Director
Michael T. Cullen
/s/ Daniel J. Donovan
Director
Daniel J. Donovan
/s/ Arthur J. Fratamico
Director
Arthur J. Fratamico
/s/ Jeffrey E. Jacob
Director
Jeffrey E. Jacob
/s/ Jeffrey S. Mathiesen
Director
Jeffrey S. Mathiesen
/s/ D. Robert Schemel
Director
D. Robert Schemel