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    <title>Unassociated Document</title>
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    <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt" align="center"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman;"><strong>As
      filed with the Securities and Exchange Commission on April 2,
      2007</strong></font></div>
    <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt" align="right"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman;"><strong>Registration
      No. 333-______</strong></font></div>
    <div>
      <hr style="MARGIN-TOP: -5px; COLOR: #000000" noshade size="4">
      <hr style="MARGIN-TOP: -10px; COLOR: #000000" noshade size="1">
    </div>
    <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt" align="center"><font style="DISPLAY: inline; FONT-SIZE: 12pt; FONT-FAMILY: Times New Roman;"><strong>SECURITIES
      AND EXCHANGE COMMISSION</strong></font></div>
    <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt" align="center"><font style="DISPLAY: inline; FONT-SIZE: 12pt; FONT-FAMILY: Times New Roman;"><strong>WASHINGTON,
      D.C. 20549</strong></font></div>
    <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt" align="center">&#160;</div>
    <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt" align="center">
      <hr style="COLOR: black" align="center" noshade size="2" width="30%">&#160;</div>
    <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt" align="center"><font style="DISPLAY: inline; FONT-SIZE: 12pt; FONT-FAMILY: Times New Roman;"><strong>FORM
      S-8</strong></font></div>
    <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt" align="center"><font style="DISPLAY: inline; FONT-SIZE: 12pt; FONT-FAMILY: Times New Roman;"><strong>REGISTRATION
      STATEMENT</strong></font></div>
    <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt" align="center"><font style="DISPLAY: inline; FONT-SIZE: 12pt; FONT-FAMILY: Times New Roman;"><strong>UNDER
      THE SECURITIES ACT OF 1933</strong></font></div>
    <div><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman;">&#160;</font>
      <div>
        <hr style="COLOR: black" align="center" noshade size="2" width="30%">
      </div>
    </div>
    <div>&#160;</div>
    <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt" align="center"><font style="DISPLAY: inline; FONT-SIZE: 18pt; FONT-FAMILY: Times New Roman;"><strong>MATRITECH,
      INC.</strong></font></div>
    <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt" align="center"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman;"><strong>(Exact
      name of registrant as specified in its charter)</strong></font></div>
    <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt" align="center">&#160;</div>
    <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt" align="center">
      <hr style="COLOR: black" align="center" noshade size="2" width="30%">
    </div>
    <div><br></div>
    <div>
      <div align="left">
        <table border="0" cellpadding="0" cellspacing="0" width="100%">

            <tr>
              <td align="left" valign="top" width="50%" style="BORDER-BOTTOM: black">
                <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt" align="center"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: times new roman;"><strong>Delaware</strong></font></div>
              </td>
              <td align="left" valign="top" width="50%" style="BORDER-BOTTOM: black">
                <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt" align="center"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: times new roman;"><strong>04-2985132</strong></font></div>
              </td>
            </tr>
            <tr>
              <td align="left" valign="top" width="50%" style="BORDER-BOTTOM: black">
                <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt" align="center"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: times new roman;">(State
                  or other jurisdiction of incorporation or organization)</font></div>
              </td>
              <td align="left" valign="top" width="50%" style="BORDER-BOTTOM: black">
                <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt" align="center"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: times new roman;">(I.R.S.
                  Employer Identification No.)</font></div>
              </td>
            </tr>

        </table>
      </div>
    </div>
    <div>&#160;</div>
    <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt" align="center"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman;"><strong>330
      Nevada Street</strong></font></div>
    <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt" align="center"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman;"><strong>Newton,
      Massachusetts 02460</strong></font></div>
    <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt" align="center"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman;"><strong>(617)
      928-0820</strong></font></div>
    <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt" align="center"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman;">(Address,
      Including Zip Code and Telephone Number, Including Area Code, of Registrant&#8217;s
      Principal Executive Offices)</font></div>
    <div><br></div>
    <div>
      <hr style="COLOR: black" align="center" noshade size="2" width="30%">&#160;<br></div>
    <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt" align="center"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman;"><strong>2006
      Equity and Incentive Plan</strong></font></div>
    <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt" align="center"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman;"><strong>as
      amended September 15, 2006</strong></font></div>
    <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt" align="center"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman;">(Full
      title of the plan)</font></div>
    <div><br></div>
    <div>
      <hr style="COLOR: black" align="center" noshade size="2" width="30%">&#160;<br></div>
    <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt" align="center"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman;"><strong>Stephen
      D. Chubb</strong></font></div>
    <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt" align="center"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman;">Chief
      Executive Officer</font></div>
    <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt" align="center"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman;">MATRITECH,
      INC.</font></div>
    <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt" align="center"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman;">330
      Nevada Street</font></div>
    <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt" align="center"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman;">Newton,&#160;&#160;Massachusetts
      02460</font></div>
    <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt" align="center"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman;">(617)
      928-0820</font></div>
    <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt" align="center"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman;">(Name,
      Address, Including Zip Code and Telephone Number, Including Area Code of Agent
      for Service)</font></div>
    <div><br></div>
    <div>
      <hr style="COLOR: black" align="center" noshade size="2" width="30%">&#160;<br></div>
    <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt" align="center"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman;"><strong><em>Copy
      to:</em></strong></font></div>
    <div><br></div>
    <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt" align="center"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman;">Barbara
      F. Johnson, Esq.</font></div>
    <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt" align="center"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman;">CHOATE,
      HALL &amp; STEWART LLP</font></div>
    <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt" align="center"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman;">Two
      International Place</font></div>
    <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt" align="center"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman;">Boston,
      MA&#160;&#160;02110</font></div>
    <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt" align="center"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman;">(617)
      248-5000</font></div>
    <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt" align="center">&#160;</div>
    <div>
      <hr style="COLOR: black" align="center" noshade size="2" width="30%">
    </div>
    <div>&#160;</div>
    <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt" align="center"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman;"><strong>CALCULATION
      OF REGISTRATION FEE</strong></font></div>
    <div><br></div>
    <div>
      <div align="left">
        <div align="left">
          <div align="left">
            <div align="left">
              <div align="left">
                <div align="left">
                  <div align="left">
                    <div align="left">
                      <div align="left">
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                          <div align="left">
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                                        <div align="left">
                                          <table border="0" cellpadding="0" cellspacing="0" width="100%">

                                              <tr>
                                                <td align="left" valign="bottom" width="36%" style="BORDER-BOTTOM: black 2px solid"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: times new roman;">&#160;</font></td>
                                                <td align="left" valign="bottom" width="20%" style="BORDER-BOTTOM: black 2px solid"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: times new roman;">&#160;</font></td>
                                                <td align="left" valign="bottom" width="2%" style="PADDING-BOTTOM: 2px; BORDER-BOTTOM: black 2px solid"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: times new roman;">&#160;</font></td>
                                                <td align="left" colspan="2" valign="bottom" width="11%" style="BORDER-BOTTOM: black 2px solid"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: times new roman;">&#160;</font></td>
                                                <td align="left" nowrap valign="bottom" width="2%" style="PADDING-BOTTOM: 2px; BORDER-BOTTOM: black 2px solid"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: times new roman;">&#160;</font></td>
                                                <td align="left" valign="bottom" width="2%" style="PADDING-BOTTOM: 2px; BORDER-BOTTOM: black 2px solid"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: times new roman;">&#160;</font></td>
                                                <td align="left" colspan="2" valign="bottom" width="11%" style="BORDER-BOTTOM: black 2px solid"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: times new roman;">&#160;</font></td>
                                                <td align="left" nowrap valign="bottom" width="2%" style="PADDING-BOTTOM: 2px; BORDER-BOTTOM: black 2px solid"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: times new roman;">&#160;</font></td>
                                                <td align="left" valign="bottom" width="2%" style="PADDING-BOTTOM: 2px; BORDER-BOTTOM: black 2px solid"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: times new roman;">&#160;</font></td>
                                                <td align="left" colspan="2" valign="bottom" width="11%" style="BORDER-BOTTOM: black 2px solid"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: times new roman;">&#160;</font></td>
                                                <td align="left" nowrap valign="bottom" width="1%" style="PADDING-BOTTOM: 2px; BORDER-BOTTOM: black 2px solid"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: times new roman;">&#160;</font></td>
                                              </tr>
                                              <tr>
                                                <td align="left" valign="bottom" width="36%" style="BORDER-BOTTOM: black 2px solid">
                                                  <div>&#160;</div>
                                                  <div>&#160;</div>
                                                  <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt" align="left"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: times new roman;">Title
                                                    of Securities to be Registered</font></div>
                                                </td>
                                                <td align="left" valign="bottom" width="20%" style="BORDER-BOTTOM: black 2px solid">
                                                  <div>&#160;</div>
                                                  <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt" align="center"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: times new roman;">Amount
                                                    to be </font></div>
                                                  <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt" align="center"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: times new roman;">Registered(1)</font></div>
                                                </td>
                                                <td align="left" valign="bottom" width="2%" style="PADDING-BOTTOM: 2px; BORDER-BOTTOM: black 2px solid"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: times new roman;">&#160;
                                                  </font></td>
                                                <td align="left" colspan="2" valign="bottom" width="11%" style="BORDER-BOTTOM: black 2px solid">
                                                  <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt" align="center"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: times new roman;">Proposed</font></div>
                                                  <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt" align="center"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: times new roman;">Maximum</font></div>
                                                  <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt" align="center"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: times new roman;">Offering&#160;Price</font></div>
                                                  <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt" align="center"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: times new roman;">Per
                                                    Share</font></div>
                                                </td>
                                                <td align="left" nowrap valign="bottom" width="2%" style="PADDING-BOTTOM: 2px; BORDER-BOTTOM: black 2px solid"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: times new roman;">&#160;</font></td>
                                                <td align="left" valign="bottom" width="2%" style="PADDING-BOTTOM: 2px; BORDER-BOTTOM: black 2px solid"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: times new roman;">&#160;</font></td>
                                                <td align="left" colspan="2" valign="bottom" width="11%" style="BORDER-BOTTOM: black 2px solid">
                                                  <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt" align="center"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: times new roman;">Proposed
                                                    </font></div>
                                                  <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt" align="center"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: times new roman;">Maximum
                                                    </font></div>
                                                  <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt" align="center"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: times new roman;">Offering
                                                    </font></div>
                                                  <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt" align="center"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: times new roman;">Price</font></div>
                                                </td>
                                                <td align="left" nowrap valign="bottom" width="2%" style="PADDING-BOTTOM: 2px; BORDER-BOTTOM: black 2px solid"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: times new roman;">&#160;</font></td>
                                                <td align="left" valign="bottom" width="2%" style="PADDING-BOTTOM: 2px; BORDER-BOTTOM: black 2px solid"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: times new roman;">&#160;</font></td>
                                                <td align="left" colspan="2" valign="bottom" width="11%" style="BORDER-BOTTOM: black 2px solid">
                                                  <div>
                                                  </div>
                                                  <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt" align="center"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: times new roman;">Amount
                                                    of </font></div>
                                                  <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt" align="center"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: times new roman;">Registration
                                                    </font></div>
                                                  <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt" align="center"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: times new roman;">Fee(3)</font></div>
                                                </td>
                                                <td align="left" nowrap valign="bottom" width="1%" style="PADDING-BOTTOM: 2px; BORDER-BOTTOM: black 2px solid"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: times new roman;">&#160;</font></td>
                                              </tr>
                                              <tr>
                                                <td align="left" valign="bottom" width="36%" style="BORDER-BOTTOM: black">
                                                  <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt" align="left"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: times new roman;">2006
                                                    Equity and Incentive Plan as
                                                    amended September 15, 2006</font></div>
                                                  <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt" align="left"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: times new roman;">Common
                                                    Stock, $.01 par value</font></div>
                                                </td>
                                                <td align="left" valign="bottom" width="20%" style="BORDER-BOTTOM: black">
                                                  <div style="MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt" align="center"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: times new roman;">4,000,000
                                                    shares</font></div>
                                                </td>
                                                <td align="left" valign="bottom" width="2%" style="BORDER-BOTTOM: black"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: times new roman;">&#160;</font></td>
                                                <td align="left" valign="bottom" width="1%" style="BORDER-BOTTOM: black"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: times new roman;">$</font></td>
                                                <td align="right" valign="bottom" width="10%" style="BORDER-BOTTOM: black"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: times new roman;">0.51</font></td>
                                                <td align="left" nowrap valign="bottom" width="2%" style="BORDER-BOTTOM: black"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: times new roman;">(2)</font></td>
                                                <td align="left" valign="bottom" width="2%" style="BORDER-BOTTOM: black"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: times new roman;">&#160;</font></td>
                                                <td align="left" valign="bottom" width="1%" style="BORDER-BOTTOM: black"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: times new roman;">$</font></td>
                                                <td align="right" valign="bottom" width="10%" style="BORDER-BOTTOM: black">
                                                  <div>
                                                  </div>
                                                  <div style="DISPLAY: block; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt" align="right"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: times new roman;">2,040,000</font></div>
                                                </td>
                                                <td align="left" nowrap valign="bottom" width="2%" style="BORDER-BOTTOM: black"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: times new roman;">&#160;</font></td>
                                                <td align="left" valign="bottom" width="2%" style="BORDER-BOTTOM: black"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: times new roman;">&#160;</font></td>
                                                <td align="left" valign="bottom" width="1%" style="BORDER-BOTTOM: black"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: times new roman;">$</font></td>
                                                <td align="right" valign="bottom" width="10%" style="BORDER-BOTTOM: black">
                                                  <div>
                                                  </div>
                                                  <div style="DISPLAY: block; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt" align="right"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: times new roman;">30.70</font></div>
                                                </td>
                                                <td align="left" nowrap valign="bottom" width="1%" style="BORDER-BOTTOM: black"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: times new roman;">&#160;</font></td>
                                              </tr>
                                              <tr>
                                                <td align="left" valign="bottom" width="36%" style="BORDER-BOTTOM: black 2px solid"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman;">&#160;</font></td>
                                                <td align="left" valign="bottom" width="20%" style="BORDER-BOTTOM: black 2px solid"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman;">&#160;</font></td>
                                                <td align="left" valign="bottom" width="2%" style="BORDER-BOTTOM: black 2px solid"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman;">&#160;</font></td>
                                                <td align="left" valign="bottom" width="1%" style="BORDER-BOTTOM: black 2px solid"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman;">&#160;</font></td>
                                                <td align="right" valign="bottom" width="10%" style="BORDER-BOTTOM: black 2px solid"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman;">&#160;</font></td>
                                                <td align="left" nowrap valign="bottom" width="2%" style="BORDER-BOTTOM: black 2px solid"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman;">&#160;</font></td>
                                                <td align="left" valign="bottom" width="2%" style="BORDER-BOTTOM: black 2px solid"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman;">&#160;</font></td>
                                                <td align="left" valign="bottom" width="1%" style="BORDER-BOTTOM: black 2px solid"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman;">&#160;</font></td>
                                                <td align="right" valign="bottom" width="10%" style="BORDER-BOTTOM: black 2px solid"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman;">&#160;</font></td>
                                                <td align="left" nowrap valign="bottom" width="2%" style="BORDER-BOTTOM: black 2px solid"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman;">&#160;</font></td>
                                                <td align="left" valign="bottom" width="2%" style="BORDER-BOTTOM: black 2px solid"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman;">&#160;</font></td>
                                                <td align="left" valign="bottom" width="1%" style="BORDER-BOTTOM: black 2px solid"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman;">&#160;</font></td>
                                                <td align="right" valign="bottom" width="10%" style="BORDER-BOTTOM: black 2px solid"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman;">&#160;</font></td>
                                                <td align="left" nowrap valign="bottom" width="1%" style="BORDER-BOTTOM: black 2px solid"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman;">&#160;</font></td>
                                              </tr>

                                          </table>
                                        </div>
                                      </div>
                                    </div>
                                  </div>
                                </div>
                              </div>
                            </div>
                          </div>
                        </div>
                      </div>
                    </div>
                  </div>
                </div>
              </div>
            </div>
          </div>
        </div>
      </div>
    </div>
    <div><br></div>
    <div>
      <div>
        <hr style="COLOR: black" align="left" noshade size="3" width="100%">
      </div><br></div>
    <div>
      <table align="center" border="0" cellpadding="0" cellspacing="0" id="hangingindent" width="100%">

          <tr valign="top">
            <td style="WIDTH: 18pt">
              <div><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman;">(1)</font></div>
            </td>
            <td>
              <div align="left"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman;">In
                addition, pursuant to Rule 416(a) under the Securities Act of 1933,
                as
                amended (the &#8220;Securities Act&#8221;), this Registration Statement also covers
                such indeterminate amount of additional shares of Common Stock as
                is
                necessary to eliminate any dilutive effect of any future stock splits,
                stock dividends or similar
                transactions.</font></div>
            </td>
          </tr>

      </table>
    </div>
    <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt" align="justify">&#160;</div>
    <div>
      <table align="center" border="0" cellpadding="0" cellspacing="0" id="hangingindent" width="100%">

          <tr valign="top">
            <td style="WIDTH: 24px">
              <div><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman;">(2)</font></div>
            </td>
            <td width="1217">
              <div align="left"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman;">The
                price of $0.51 per share, which is the average of the high and low
                sales
                prices per share of Common Stock on the American Stock Exchange on
                March
                29, 2007 is set forth solely for the purpose of calculating the
                registration fee in accordance with Rule 457(c) under the Securities
                Act
                and has been used only for those shares without a fixed exercise
                price.</font></div>
            </td>
          </tr>

      </table>
    </div>
    <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt" align="justify">&#160;</div>
    <div>
      <table align="center" border="0" cellpadding="0" cellspacing="0" id="hangingindent" width="100%" style="MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt">

          <tr valign="top">
            <td style="WIDTH: 18pt">
              <div style="MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt" align="left"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman;">(3)</font></div>
            </td>
            <td>
              <div align="left"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman;">Calculated
                pursuant to Section 6(b) of the Securities Act, as
                amended.</font></div>
            </td>
          </tr>

      </table>
    </div>
    <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt" align="justify"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman;">&#160;</font>
      <div>
        <hr style="COLOR: black" align="left" noshade size="3" width="100%">
      </div>
    </div>
    <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt" align="justify">&#160;</div>
    <div id="PGBRK" style="MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt">
      <div id="FTR">
        <div id="GLFTR" style="WIDTH: 100%" align="left">
        </div>
      </div>
      <div id="PN" style="PAGE-BREAK-AFTER: always">
        <div style="WIDTH: 100%; TEXT-ALIGN: center">
        </div>
        <div style="WIDTH: 100%; TEXT-ALIGN: center">
        </div>
      </div>
      <div id="HDR">
        <div id="GLHDR" style="WIDTH: 100%" align="right">
        </div>
      </div>
    </div>
    <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt" align="center"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman;"><strong>PART&#160;I</strong></font></div>
    <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt" align="center"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman;"><strong>INFORMATION
      REQUIRED IN THE SECTION 10(A) PROSPECTUS</strong></font></div>
    <div><br></div>
    <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt" align="left"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman;"><font id="TAB1" style="MARGIN-LEFT: 36pt;"></font>The
      documents containing the
      information specified in Item&#160;1 and Item&#160;2 of Form&#160;S-8 will be
      sent or given to the employees, officers and directors who have been granted
      options, restricted stock, restricted stock units or other awards under the
      2006
      Equity and Incentive Plan as amended September 15,
      2006,<strong>&#160;</strong>as specified by Rule 428(b)(1) of the Securities
      Act.&#160;&#160;In accordance with the rules and regulations of the Securities
      and Exchange Commission (the &#8220;SEC&#8221;) and the instructions to Form&#160;S-8, such
      documents are not being filed with the SEC either as part of this Registration
      Statement or as Prospectuses or Prospectus Supplements pursuant to
      Rule&#160;424.</font></div>
    <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt" align="center">&#160;</div>
    <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt" align="center">&#160;</div>
    <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt" align="center">&#160;</div>
    <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt" align="center">&#160;</div>
    <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt" align="center">&#160;</div>
    <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt" align="center">&#160;</div>
    <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt" align="center">&#160;</div>
    <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt" align="center">&#160;</div>
    <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt" align="center">&#160;</div>
    <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt" align="center">&#160;</div>
    <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt" align="center">&#160;</div>
    <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt" align="center">&#160;</div>
    <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt" align="center">&#160;</div>
    <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt" align="center">&#160;</div>
    <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt" align="center">&#160;</div>
    <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt" align="center">&#160;</div>
    <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt" align="center">&#160;</div>
    <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt" align="center">&#160;</div>
    <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt" align="center">&#160;</div>
    <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt" align="center">&#160;</div>
    <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt" align="center">&#160;</div>
    <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt" align="center">&#160;</div>
    <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt" align="center">&#160;</div>
    <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt" align="center">&#160;</div>
    <div id="PGBRK" style="MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt">
      <div id="FTR">
        <div id="GLFTR" style="WIDTH: 100%" align="left">
        </div>
      </div>
      <div id="PN" style="PAGE-BREAK-AFTER: always">
        <div style="WIDTH: 100%; TEXT-ALIGN: center"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman;">-2-</font></div>
        <div style="WIDTH: 100%; TEXT-ALIGN: center">
          <hr style="COLOR: black" noshade size="2">
        </div>
      </div>
      <div id="HDR">
        <div id="GLHDR" style="WIDTH: 100%" align="right">
        </div>
      </div>
    </div>
    <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt" align="center"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman;"><strong>PART&#160;II</strong></font></div>
    <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt" align="center"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman;"><strong>INFORMATION
      REQUIRED IN THE REGISTRATION STATEMENT</strong></font></div>
    <div><br></div>
    <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt" align="left"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman;"><strong>ITEM&#160;3.&#160;&#160;INCORPORATION
      OF DOCUMENTS BY REFERENCE.</strong></font></div>
    <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt" align="justify">&#160;</div>
    <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt" align="left"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman;">The
      following documents filed by Matritech, Inc. (&#8220;Matritech&#8221; or the &#8220;Company&#8221;) with
      the SEC, File No. 001-12128 are incorporated in this Registration Statement
      by
      reference as of their respective dates:</font></div>
    <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt" align="justify">&#160;</div>
    <div>
      <table align="center" border="0" cellpadding="0" cellspacing="0" id="hangingindent" width="100%">

          <tr valign="top">
            <td style="WIDTH: 36pt">
              <div>&#160;</div>
            </td>
            <td style="WIDTH: 36pt">
              <div style="MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt" align="left"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman;">(a)</font></div>
            </td>
            <td>
              <div align="left"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman;">Matritech&#8217;s
                Annual Report on Form 10-K for the fiscal year ended December 31,
                2006,
                filed under the Securities Exchange Act of 1934 (the &#8220;Exchange Act&#8217;) on
                March 27, 2007;</font></div>
            </td>
          </tr>

      </table>
    </div>
    <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt" align="justify">&#160;</div>
    <div>
      <table align="center" border="0" cellpadding="0" cellspacing="0" id="hangingindent" width="100%">

          <tr valign="top">
            <td style="WIDTH: 36pt">
              <div>&#160;</div>
            </td>
            <td style="WIDTH: 36pt">
              <div style="MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt" align="left"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman;">(b)</font></div>
            </td>
            <td>
              <div align="left"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman;">Matritech&#8217;s
                Current Reports on Form&#160;8-K filed on January 19, 2007, January 24,
                2007, February 6, 2007, March 1, 2007, March 19, 2007 and March 30,
                2007,
                provided that the information deemed &#8220;furnished&#8221; in such reports and not
                deemed &#8220;filed&#8221; is not incorporated herein;
                and</font></div>
            </td>
          </tr>

      </table>
    </div>
    <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt" align="justify">&#160;</div>
    <div>
      <table align="center" border="0" cellpadding="0" cellspacing="0" id="hangingindent" width="100%">

          <tr valign="top">
            <td style="WIDTH: 36pt">
              <div>&#160;</div>
            </td>
            <td style="WIDTH: 36pt">
              <div style="MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt" align="left"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman;">(c)</font></div>
            </td>
            <td>
              <div align="left"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman;">The
                section entitled &#8220;Description of Registrant&#8217;s Securities to be Registered&#8221;
                contained in Matritech&#8217;s Registration Statement on Form&#160;S-1, as
                amended, which was incorporated by reference in Matritech&#8217;s Registration
                Statement on Form 8-A filed pursuant to Section 12(g) of the Exchange
                Act
                filed with the Commission on March 10, 1992, including any amendment
                or
                report filed for the purpose of updating the description of Matritech&#8217;s
                common stock.</font></div>
            </td>
          </tr>

      </table>
    </div>
    <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt" align="justify">&#160;</div>
    <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt" align="left"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman;">All
      documents subsequently filed with the SEC by Matritech pursuant to Sections
      13(a), 13(c), 14 and 15(d) of the Exchange Act, prior to the filing of a
      post-effective amendment that indicates that all securities offered herein
      have
      been sold or that deregisters all securities then remaining unsold, shall be
      deemed to be incorporated by reference in this Registration Statement and to
      be
      a part hereof from the date of filing of such documents.</font></div>
    <div><br></div>
    <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt" align="left"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman;"><strong>ITEM
      4.&#160;&#160;DESCRIPTION OF SECURITIES.</strong></font></div>
    <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt" align="justify">&#160;</div>
    <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt" align="left"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman;">Not
      applicable.</font></div>
    <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt" align="justify">&#160;</div>
    <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt" align="left"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman;"><strong>ITEM
      5.&#160;&#160;INTEREST OF NAMED EXPERTS AND COUNSEL.</strong></font></div>
    <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt" align="justify">&#160;</div>
    <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt" align="left"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman;">Not
      applicable.</font></div>
    <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt" align="justify">&#160;</div>
    <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt" align="left"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman;"><strong>ITEM
      6.&#160;&#160;INDEMNIFICATION OF DIRECTORS AND OFFICERS.</strong></font></div>
    <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt" align="justify">&#160;</div>
    <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt" align="left"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman;">Pursuant
      to the provisions of Section 145 of the Delaware General Corporation Law
      (&#8220;DGCL&#8221;) the Company has the power to indemnify certain persons, including its
      officers and directors, under stated circumstances and subject to certain
      limitations, for liabilities incurred in connection with services performed
      in
      good faith for the Company or for other organizations at the request of the
      Company.</font></div>
    <div><br></div>
    <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt" align="left"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman;">Article
      Seventh of the Company&#8217;s Amended and Restated Certificate of Incorporation, as
      amended, provides that no director of the Company shall be liable for monetary
      damages for breach of fiduciary duty, except to the extent that the DGCL
      prohibits the elimination of liability of directors for breach of fiduciary
      duty.</font></div>
    <div><br></div>
    <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt" align="left"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman;">Article
      Twelfth of the Company&#8217;s Amended and Restated Certificate of Incorporation, as
      amended, provides that a director or officer of the Company (a) shall be
      indemnified by the Company against all expenses (including attorneys&#8217; fees),
      judgments, fines and amounts paid in settlement incurred in connection with
      any
      litigation or other legal proceeding (other than an action by or in the right
      of
      the </font></div>
    <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt" align="left">&#160;</div>
    <div id="PGBRK" style="MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt">
      <div id="FTR">
        <div id="GLFTR" style="WIDTH: 100%" align="left">
        </div>
      </div>
      <div id="PN" style="PAGE-BREAK-AFTER: always">
        <div style="WIDTH: 100%; TEXT-ALIGN: center"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman;">-3-</font></div>
        <div style="WIDTH: 100%; TEXT-ALIGN: center">
          <hr style="COLOR: black" noshade size="2">
        </div>
      </div>
      <div id="HDR">
        <div id="GLHDR" style="WIDTH: 100%" align="right">
        </div>
      </div>
    </div>
    <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt" align="left"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman;">Company)
      brought against him by virtue of his position as a director or officer of the
      Company if he acted in good faith and in a manner he reasonably believed to
      be
      in, or not opposed to, the best interests of the Company, and, with respect
      to
      any criminal action or proceeding, had no reasonable cause to believe his
      conduct was unlawful and (b) shall be indemnified by the Company against all
      expenses (including attorneys&#8217; fees) and amounts paid in settlement incurred in
      connection with any action by or in the right of the Company brought against
      him
      by virtue of his position as a director or officer of the Company if he acted
      in
      good faith and in a manner he reasonably believed to be in, or not opposed
      to,
      the best interests of the Company, except that no indemnification shall be
      made
      with respect to any matter as to which such person shall have been adjudged
      to
      be liable to the Company, unless a court determines that despite such
      adjudication but in view of all of the circumstances, he is entitled to
      indemnification of such expenses.</font></div>
    <div><br></div>
    <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt" align="left"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman;">Notwithstanding
      the foregoing, to the extent that a director or officer has been successful,
      on
      the merits or otherwise, including, without limitation, the dismissal of an
      action without prejudice, he is required to be indemnified by the Company
      against all expenses (including attorneys&#8217; fees) incurred in connection
      therewith. Expenses shall be advanced to a director or officer at his request,
      provided that he undertakes to repay the amount advanced if it is ultimately
      determined that he is not entitled to indemnification for such
      expenses.</font></div>
    <div><br></div>
    <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt" align="left"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman;">Article
      Twelfth of the Company&#8217;s Amended and Restated Certificate of Incorporation, as
      amended, further provides that the indemnification provided therein is not
      exclusive and provides that in the event that the DGCL is amended to expand
      or
      limit the indemnification permitted to directors or officers, the Company must
      indemnify those persons to the fullest extent permitted by such law, as so
      amended.</font></div>
    <div><br></div>
    <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt" align="left"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman;">In
      addition to the indemnification provided by Section 145 of the DGCL, the Company
      has entered into an Indemnity Agreement with each of its directors pursuant
      to
      which the Company agrees to indemnify that director for (1) all expenses,
      liabilities, judgments, fines and amounts paid in settlement actually and
      reasonably incurred in connection with any legal action, suit or proceeding
      against the director by reason of the fact that he was an agent of the Company
      if he acted in good faith and in a manner he reasonably believed to be in or
      not
      opposed to the best interests of the Company, and with respect to any criminal
      proceedings had no reasonable cause to believe his conduct was unlawful, and
      (2)
      all expenses incurred in connection with the investigation, defense, settlement
      or appeal of any legal action or proceeding brought against the director by
      or
      in the right of the Company by reason of any action taken or not taken by him
      in
      his capacity as a director of the Company if he acted in good faith and in
      a
      manner he reasonably believed to be in or not opposed to the best interests
      of
      the Company. The Company is not obligated under the terms of the Indemnity
      Agreements to indemnify its directors (a) for expenses or liabilities paid
      directly to the directors by directors&#8217; and officers&#8217; insurance, (b) on account
      of any claims against the directors for an accounting of profits made from
      the
      purchase or sale by directors of securities of the Company pursuant to Section
      16(b) of the Exchange Act, as amended, (c) if indemnification would not be
      lawful.</font></div>
    <div><br></div>
    <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt" align="left"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman;">The
      Company also maintains directors&#8217; and officers&#8217; liability insurance to insure
      its directors and certain officers against certain liabilities and expenses
      that
      arise out of or in connection with their capacities as directors and
      officers.</font></div>
    <div><br></div>
    <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt" align="left"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman;"><strong>ITEM
      7.&#160;&#160;EXEMPTION FROM REGISTRATION CLAIMED.</strong></font></div>
    <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt" align="justify">&#160;</div>
    <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt" align="left"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman;">Not
      applicable.</font></div>
    <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt" align="justify">&#160;</div>
    <div id="PGBRK" style="MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt">
      <div id="FTR">
        <div id="GLFTR" style="WIDTH: 100%" align="left">
        </div>
      </div>
      <div id="PN" style="PAGE-BREAK-AFTER: always">
        <div style="WIDTH: 100%; TEXT-ALIGN: center"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman;">-4-</font></div>
        <div style="WIDTH: 100%; TEXT-ALIGN: center">
          <hr style="COLOR: black" noshade size="2">
        </div>
      </div>
      <div id="HDR">
        <div id="GLHDR" style="WIDTH: 100%" align="right">
        </div>
      </div>
    </div>
    <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt" align="left"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman;"><strong>ITEM
      8.&#160;&#160;EXHIBITS</strong></font></div>
    <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt" align="justify">&#160;</div>
    <div>
      <table align="center" border="0" cellpadding="0" cellspacing="0" id="hangingindent" width="100%" style="MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt">

          <tr valign="top">
            <td style="WIDTH: 18pt">
            </td>
            <td style="WIDTH: 108pt">
              <div style="MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt" align="left"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman;"><u><strong>Exhibit
                No.</strong></u></font></div>
            </td>
            <td>
              <div align="left"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman;"><strong><u>Description
                of Exhibit</u></strong></font></div>
            </td>
          </tr>

      </table>
    </div>
    <div>&#160;</div>
    <div>
      <table align="center" border="0" cellpadding="0" cellspacing="0" id="hangingindent" width="100%" style="MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt">

          <tr valign="top">
            <td style="WIDTH: 18pt">
            </td>
            <td style="WIDTH: 108pt">
              <div style="MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt" align="left"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman;">Exhibit
                4.1</font></div>
            </td>
            <td>
              <div align="left"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman;">Specimen
                Common Stock Certificate (originally filed as Exhibit&#160;4.2 to
                Matritech&#8217;s Registration Statement No. 33-46158 on Form&#160;S-1 and
                incorporated herein by reference).</font></div>
            </td>
          </tr>

      </table>
    </div>
    <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt" align="justify">&#160;</div>
    <div>
      <table align="center" border="0" cellpadding="0" cellspacing="0" id="hangingindent" width="100%" style="MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt">

          <tr valign="top">
            <td style="WIDTH: 18pt">
            </td>
            <td style="WIDTH: 108pt">
              <div style="MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt" align="left"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman;">Exhibit
                4.2</font></div>
            </td>
            <td>
              <div align="left"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman;">Amended
                and Restated Certificate of Incorporation (originally filed as
                Exhibits&#160;3, 4.1 to Matritech&#8217;s Registration Statement
                No.&#160;33-46158 on Form&#160;S-1 and re-filed in electronic form as
                Exhibit&#160;3.1 to Matritech&#8217;s Annual Report on Form&#160;10-K for the
                fiscal year ended December&#160;31, 2001 and incorporated herein by
                reference).</font></div>
            </td>
          </tr>

      </table>
    </div>
    <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt" align="justify">&#160;</div>
    <div>
      <table align="center" border="0" cellpadding="0" cellspacing="0" id="hangingindent" width="100%" style="MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt">

          <tr valign="top">
            <td style="WIDTH: 18pt">
            </td>
            <td style="WIDTH: 108pt">
              <div style="MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt" align="left"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman;">Exhibit
                4.3</font></div>
            </td>
            <td>
              <div align="left"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman;">Amended
                and Restated By-Laws (originally filed as Exhibits&#160;3.2, 4.1 to
                  Matritech&#8217;s Registration Statement No.&#160;33-46158 on Form&#160;S-1 and
                re-filed in electronic form as Exhibit&#160;3.2 to Matritech&#8217;s Annual
                Report on Form&#160;10-K for the fiscal year ended December&#160;31, 2001
                and incorporated herein by
                reference).</font></div>
            </td>
          </tr>

      </table>
    </div>
    <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt" align="justify">&#160;</div>
    <div>
      <table align="center" border="0" cellpadding="0" cellspacing="0" id="hangingindent" width="100%" style="MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt">

          <tr valign="top">
            <td style="WIDTH: 18pt">
            </td>
            <td style="WIDTH: 108pt">
              <div style="MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt" align="left"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman;">Exhibit
                4.4</font></div>
            </td>
            <td>
              <div align="left"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman;">Certificate
                of Amendment dated June&#160;16, 1994, of Amended and Restated Certificate
                of Incorporation of the Registrant (originally filed as Exhibit&#160;3.2
                of Matritech&#8217;s Quarterly Report on Form&#160;10-Q for the fiscal quarter
                ended June&#160;30, 1995 and re-filed in electronic form as
                Exhibit&#160;3.3 to Matritech&#8217;s Annual Report on Form&#160;10-K for the
                fiscal year ended December&#160;31, 2001 and incorporated herein by
                reference).</font></div>
            </td>
          </tr>

      </table>
    </div>
    <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt" align="justify">&#160;</div>
    <div>
      <table align="center" border="0" cellpadding="0" cellspacing="0" id="hangingindent" width="100%" style="MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt">

          <tr valign="top">
            <td style="WIDTH: 18pt">
            </td>
            <td style="WIDTH: 108pt">
              <div style="MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt" align="left"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman;">Exhibit
                4.5</font></div>
            </td>
            <td>
              <div align="left"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman;">Certificate
                of Amendment dated June&#160;5, 1995, of Amended and Restated Certificate
                of Incorporation of the Registrant (originally filed as Exhibit&#160;3.3
                of Matritech&#8217;s Quarterly Report on Form&#160;10-Q for the fiscal quarter
                ended June&#160;30, 1995 and re-filed in electronic form as
                Exhibit&#160;3.4 to Matritech&#8217;s Annual Report on Form&#160;10-K for the
                fiscal year ended December&#160;31, 2001 and incorporated herein by
                reference).</font></div>
            </td>
          </tr>

      </table>
    </div>
    <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt" align="justify">&#160;</div>
    <div>
      <table align="center" border="0" cellpadding="0" cellspacing="0" id="hangingindent" width="100%" style="MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt">

          <tr valign="top">
            <td style="WIDTH: 18pt">
            </td>
            <td style="WIDTH: 108pt">
              <div style="MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt" align="left"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman;">Exhibit
                4.6</font></div>
            </td>
            <td>
              <div align="left"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman;">Certificate
                of Amendment dated June&#160;26, 2002, of Amended and Restated Certificate
                of Incorporation of the Company (filed as Exhibit&#160;4.6 to Matritech&#8217;s
                Registration Statement No.&#160;333-96701 on Form&#160;S-8, filed on
                July&#160;18, 2002 and incorporated herein by
                reference).</font></div>
            </td>
          </tr>

      </table>
    </div>
    <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt" align="justify">&#160;</div>
    <div>
      <table align="center" border="0" cellpadding="0" cellspacing="0" id="hangingindent" width="100%" style="MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt">

          <tr valign="top">
            <td style="WIDTH: 18pt">
            </td>
            <td style="WIDTH: 108pt">
              <div style="MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt" align="left"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman;">Exhibit
                4.7</font></div>
            </td>
            <td>
              <div align="left"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman;">Certificate
                of Amendment, dated June&#160;11, 2004, of Amended and Restated
                Certificate of Incorporation (filed as Exhibit&#160;3.5 to Matritech&#8217;s
                Quarterly Report on Form&#160;10-Q for the fiscal quarter ended
                June&#160;30, 2004 and incorporated herein by
                reference).</font></div>
            </td>
          </tr>

      </table>
    </div>
    <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt" align="justify">&#160;</div>
    <div>
      <table align="center" border="0" cellpadding="0" cellspacing="0" id="hangingindent" width="100%" style="MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt">

          <tr valign="top">
            <td style="WIDTH: 18pt">
            </td>
            <td style="WIDTH: 108pt">
              <div style="MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt" align="left"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman;">Exhibit
                4.8</font></div>
            </td>
            <td>
              <div align="left"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman;">Certificate
                of Amendment dated June 9, 2006 of Amended and Restated Certificate
                of
                Incorporation of the Company (filed as Exhibit 3.1 to Matritech&#8217;s Current
                Report on Form 8-K filed on June 13, 2006 and incorporated herein
                by
                reference).</font></div>
            </td>
          </tr>

      </table>
    </div>
    <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt" align="justify">&#160;</div>
    <div>
      <table align="center" border="0" cellpadding="0" cellspacing="0" id="hangingindent" width="100%" style="MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt">

          <tr valign="top">
            <td style="WIDTH: 18pt">
            </td>
            <td style="WIDTH: 108pt">
              <div style="MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt" align="left"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman;">Exhibit
                4.9</font></div>
            </td>
            <td>
              <div align="left"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman;">Certificate
                of Designations, Preferences and Rights of Series&#160;A Convertible
                Preferred Stock, dated March&#160;4, 2005 (filed as Exhibit&#160;4.1 to
                Matritech&#8217;s Current Report on Form&#160;8-K filed on March&#160;8, 2005
                and incorporated herein by
                reference).</font></div>
            </td>
          </tr>

      </table>
    </div>
    <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt" align="justify">&#160;</div>
    <div>
      <table align="center" border="0" cellpadding="0" cellspacing="0" id="hangingindent" width="100%" style="MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt">

          <tr valign="top">
            <td style="WIDTH: 18pt">
            </td>
            <td style="WIDTH: 108pt">
              <div style="MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt" align="left"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman;">Exhibit
                4.10</font></div>
            </td>
            <td>
              <div align="left"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman;">Certificate
                of Correction of Certificate of Designations, Preferences and Rights
                of
                Series&#160;A Convertible Preferred Stock (filed as Exhibit&#160;4.1 to
                Matritech&#8217;s Form&#160;8-K/A filed March&#160;25, 2005 and incorporated
                herein by reference)</font></div>
            </td>
          </tr>

      </table>
    </div>
    <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt" align="justify">&#160;</div>
    <div id="PGBRK" style="MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt">
      <div id="FTR">
        <div id="GLFTR" style="WIDTH: 100%" align="left">
        </div>
      </div>
      <div id="PN" style="PAGE-BREAK-AFTER: always">
        <div style="WIDTH: 100%; TEXT-ALIGN: center"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman;">-5-</font></div>
        <div style="WIDTH: 100%; TEXT-ALIGN: center">
          <hr style="COLOR: black" noshade size="2">
        </div>
      </div>
      <div id="HDR">
        <div id="GLHDR" style="WIDTH: 100%" align="right">
        </div>
      </div>
    </div>
    <div>
      <table align="center" border="0" cellpadding="0" cellspacing="0" id="hangingindent" width="100%" style="MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt">

          <tr valign="top">
            <td style="WIDTH: 18pt">
            </td>
            <td style="WIDTH: 108pt">
              <div style="MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt" align="left"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman;">Exhibit
                4.11</font></div>
            </td>
            <td>
              <div align="left"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman;">Amendment
                to Certificate of Designations, Preferences and Rights of Series&#160;A
                Preferred Stock (filed as Exhibit&#160;4.1 to Matritech&#8217;s Current Report
                on Form&#160;8-K filed January&#160;17, 2006 and incorporated herein by
                reference).</font></div>
            </td>
          </tr>

      </table>
    </div>
    <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt" align="justify">&#160;</div>
    <div>
      <table align="center" border="0" cellpadding="0" cellspacing="0" id="hangingindent" width="100%" style="MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt">

          <tr valign="top">
            <td style="WIDTH: 18pt">
            </td>
            <td style="WIDTH: 108pt">
              <div style="MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt" align="left"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman;">Exhibit
                4.12</font></div>
            </td>
            <td>
              <div align="left"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman;">Amendment
                to Certificate of Designations, Preferences and Rights of Series
                A
                Preferred Stock (filed as Exhibit 4.10 to Matritech&#8217;s Form 8-K filed
                January 24, 2007 and incorporated herein by
                reference).</font></div>
            </td>
          </tr>

      </table>
    </div>
    <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt" align="justify">&#160;</div>
    <div>
      <table align="center" border="0" cellpadding="0" cellspacing="0" id="hangingindent" width="100%" style="MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt">

          <tr valign="top">
            <td style="WIDTH: 18pt">
            </td>
            <td style="WIDTH: 108pt">
              <div style="MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt" align="left"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman;">Exhibit
                4.13</font></div>
            </td>
            <td>
              <div align="left"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman;">2006
                Equity and Incentive Plan as amended September 15, 2006 (filed as
                Exhibit
                10.1 to Matritech&#8217;s Form 8-K filed September 19, 2006 and incorporated
                herein by reference).</font></div>
            </td>
          </tr>

      </table>
    </div>
    <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt" align="justify">&#160;</div>
    <div>
      <table align="center" border="0" cellpadding="0" cellspacing="0" id="hangingindent" width="100%" style="MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt">

          <tr valign="top">
            <td style="WIDTH: 18pt">
            </td>
            <td style="WIDTH: 108pt">
              <div style="MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt" align="left"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman;">Exhibit
                5.1</font></div>
            </td>
            <td>
              <div align="left"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman;">Opinion
                of Choate, Hall &amp; Stewart LLP.</font></div>
            </td>
          </tr>

      </table>
    </div>
    <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt" align="justify">&#160;</div>
    <div>
      <table align="center" border="0" cellpadding="0" cellspacing="0" id="hangingindent" width="100%" style="MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt">

          <tr valign="top">
            <td style="WIDTH: 18pt">
            </td>
            <td style="WIDTH: 108pt">
              <div style="MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt" align="left"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman;">Exhibit
                23.1</font></div>
            </td>
            <td>
              <div align="left"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman;">Consent
                of PricewaterhouseCoopers LLP, an independent registered public accounting
                firm.</font></div>
            </td>
          </tr>

      </table>
    </div>
    <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt" align="justify">&#160;</div>
    <div>
      <table align="center" border="0" cellpadding="0" cellspacing="0" id="hangingindent" width="100%" style="MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt">

          <tr valign="top">
            <td style="WIDTH: 18pt">
            </td>
            <td style="WIDTH: 108pt">
              <div style="MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt" align="left"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman;">Exhibit
                23.2</font></div>
            </td>
            <td>
              <div align="left"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman;">Consent
                of Choate, Hall &amp; Stewart LLP (included in
                Exhibit&#160;5.1).</font></div>
            </td>
          </tr>

      </table>
    </div>
    <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt" align="justify">&#160;</div>
    <div>
      <table align="center" border="0" cellpadding="0" cellspacing="0" id="hangingindent" width="100%" style="MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt">

          <tr valign="top">
            <td style="WIDTH: 18pt">
            </td>
            <td style="WIDTH: 108pt">
              <div style="MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt" align="left"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman;">Exhibit
                24.1</font></div>
            </td>
            <td>
              <div align="left"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman;">Power
                of Attorney (included as part of the signature page to this Registration
                Statement).</font></div>
            </td>
          </tr>

      </table>
    </div>
    <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt" align="justify">&#160;</div>
    <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt" align="left"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman;"><strong>ITEM
      9.&#160;&#160;UNDERTAKINGS.</strong></font></div>
    <div><br></div>
    <div>
      <table align="center" border="0" cellpadding="0" cellspacing="0" id="hangingindent" width="100%">

          <tr valign="top">
            <td style="WIDTH: 18pt">
              <div><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman;">(a)</font></div>
            </td>
            <td>
              <div align="left"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman;">Matritech
                hereby undertakes:</font></div>
            </td>
          </tr>

      </table>
    </div>
    <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt" align="justify">&#160;</div>
    <div>
      <table align="center" border="0" cellpadding="0" cellspacing="0" id="hangingindent" width="100%" style="MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt">

          <tr valign="top">
            <td style="WIDTH: 18pt">
            </td>
            <td style="WIDTH: 36pt">
              <div><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman;">(1)</font></div>
            </td>
            <td>
              <div align="left"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman;">To
                file, during any period in which offers or sales are being made,
                a
                post-effective amendment to this Registration
                Statement:</font></div>
            </td>
          </tr>

      </table>
    </div>
    <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt" align="justify">&#160;</div>
    <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt">
      <table align="center" border="0" cellpadding="0" cellspacing="0" id="hangingindent" width="100%" style="MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt">

          <tr valign="top">
            <td style="WIDTH: 54pt">
            </td>
            <td align="left" style="WIDTH: 27pt">
              <div><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman;">(i)</font></div>
            </td>
            <td align="left">
              <div align="left"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman;">To
                include any Prospectus required by Section 10(a)(3) of the Securities
                Act;</font></div>
            </td>
          </tr>

      </table>
    </div>
    <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt" align="justify">&#160;</div>
    <div>
      <table align="center" border="0" cellpadding="0" cellspacing="0" id="hangingindent" width="100%" style="MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt">

          <tr valign="top">
            <td style="WIDTH: 54pt">
            </td>
            <td style="WIDTH: 27pt">
              <div><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman;">(ii)</font></div>
            </td>
            <td>
              <div align="left"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman;">To
                reflect in the Prospectus any facts or events arising after the effective
                date of the Registration Statement (or the most recent post-effective
                amendment thereof) which, individually or in the aggregate, represent
                a
                fundamental change in the information set forth in the Registration
                Statement. Notwithstanding the foregoing, any increase or decrease
                in
                volume of securities offered (if the total dollar value of securities
                offered would not exceed that which was registered) and any deviation
                from
                the low or high and of the estimated maximum offering range may be
                reflected in the form of Prospectus filed with the SEC pursuant to
                Rule
                424(b) if, in the aggregate, the changes in volume and price represent
                no
                more than 20 percent change in the maximum aggregate offering price
                set
                forth in the &#8220;Calculation of Registration Fee&#8221; table in the effective
                Registration Statement.</font></div>
            </td>
          </tr>

      </table>
    </div>
    <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt" align="justify">&#160;</div>
    <div>
      <table align="center" border="0" cellpadding="0" cellspacing="0" id="hangingindent" width="100%" style="MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt">

          <tr valign="top">
            <td style="WIDTH: 54pt">
            </td>
            <td style="WIDTH: 27pt">
              <div><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman;">(iii)</font></div>
            </td>
            <td>
              <div align="left"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman;">To
                include any additional or changed material information with respect
                to the
                plan of distribution not previously disclosed in the Registration
                Statement or any material change to such information in the Registration
                Statement.</font></div>
            </td>
          </tr>

      </table>
    </div>
    <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt" align="justify">&#160;</div>
    <div style="DISPLAY: block; MARGIN-LEFT: 54pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt" align="left"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman;"><em>provided,
      however</em>, that paragraphs (a)(1)(i)&#160;and (a)(1)(ii)&#160;do not apply if
      the information required to be included in a post-effective amendment by those
      paragraphs is contained in reports filed with or furnished to the SEC by
      Matritech pursuant to Section&#160;13 or Section&#160;15(d) of the Exchange Act
      of 1934 that are incorporated by reference in the registration
      statement.</font></div>
    <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt" align="justify">&#160;</div>
    <div>
      <table align="center" border="0" cellpadding="0" cellspacing="0" id="hangingindent" width="100%" style="MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt">

          <tr valign="top">
            <td style="WIDTH: 18pt">
            </td>
            <td style="WIDTH: 36pt">
              <div><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman;">(2)</font></div>
            </td>
            <td>
              <div align="left"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman;">That,
                for the purpose of determining any liability under the Securities
                Act,
                each such post-effective amendment shall be deemed to be a new
                Registration Statement relating to the securities offered therein,
                and the
                offering of such securities at that time shall be deemed to be the
                initial
                bona fide offering thereof.</font></div>
            </td>
          </tr>

      </table>
    </div>
    <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt" align="justify">&#160;</div>
    <div>
      <table align="center" border="0" cellpadding="0" cellspacing="0" id="hangingindent" width="100%" style="MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt">

          <tr valign="top">
            <td style="WIDTH: 18pt">
            </td>
            <td style="WIDTH: 36pt">
              <div><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman;">(3)</font></div>
            </td>
            <td>
              <div align="left"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman;">To
                remove from registration by means of a post-effective amendment any
                of the
                securities being registered which remain unsold at the termination
                of the
                offering.</font></div>
            </td>
          </tr>

      </table>
    </div>
    <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt" align="justify">&#160;</div>
    <div id="PGBRK" style="MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt">
      <div id="FTR">
        <div id="GLFTR" style="WIDTH: 100%" align="left">
        </div>
      </div>
      <div id="PN" style="PAGE-BREAK-AFTER: always">
        <div style="WIDTH: 100%; TEXT-ALIGN: center"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman;">-6-</font></div>
        <div style="WIDTH: 100%; TEXT-ALIGN: center">
          <hr style="COLOR: black" noshade size="2">
        </div>
      </div>
      <div id="HDR">
        <div id="GLHDR" style="WIDTH: 100%" align="right">
        </div>
      </div>
    </div>
    <div>
      <table align="center" border="0" cellpadding="0" cellspacing="0" id="hangingindent" width="100%">

          <tr valign="top">
            <td style="WIDTH: 18pt">
              <div><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman;">(b)</font></div>
            </td>
            <td>
              <div align="left"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman;">Matritech
                hereby undertakes that, for purposes of determining any liability
                under
                the Securities Act, each filing of Matritech&#8217;s annual report pursuant to
                Section&#160;13(a) or Section&#160;15(d) of the Exchange Act (and, where
                applicable, each filing of an employee benefit plan's annual report
                pursuant to Section&#160;15(d) of the Exchange Act) that is incorporated
                by reference in the Registration Statement shall be deemed to be
                a new
                Registration Statement relating to the securities offered therein,
                and the
                offering of such securities at that time shall be deemed to be the
                initial
                bona fide offering thereof.</font></div>
            </td>
          </tr>

      </table>
    </div>
    <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt" align="justify">&#160;</div>
    <div>
      <table align="center" border="0" cellpadding="0" cellspacing="0" id="hangingindent" width="100%">

          <tr valign="top">
            <td style="WIDTH: 18pt">
              <div><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman;">(c)</font></div>
            </td>
            <td>
              <div align="left"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman;">Insofar
                as indemnification for liabilities arising under the Securities Act
                may be
                permitted to directors, officers and controlling persons of Matritech
                pursuant to the provisions described in Item&#160;6, or otherwise,
                Matritech has been advised that in the opinion of the SEC such
                indemnification is against public policy as expressed in the Act
                and is,
                therefore, unenforceable.&#160;&#160;In the event that a claim for
                indemnification against such liabilities (other than the payment
                by
                Matritech of expenses incurred or paid by a director, officer or
                controlling person of Matritech in the successful defense of any
                action,
                suit or proceeding) is asserted by such director, officer or controlling
                person in connection with the securities being registered, Matritech
                will,
                unless in the opinion of its counsel the matter has been settled
                by
                controlling precedent, submit to a court of appropriate jurisdiction
                the
                question whether such indemnification by it is against public policy
                as
                expressed in the Act and will be governed by the final adjudication
                of
                such issue.</font></div>
            </td>
          </tr>

      </table>
    </div>
    <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt" align="justify">&#160;</div>
    <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt" align="justify">&#160;</div>
    <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt" align="justify">&#160;</div>
    <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt" align="justify">&#160;</div>
    <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt" align="justify">&#160;</div>
    <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt" align="justify">&#160;</div>
    <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt" align="justify">&#160;</div>
    <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt" align="justify">&#160;</div>
    <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt" align="justify">&#160;</div>
    <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt" align="justify">&#160;</div>
    <div id="PGBRK" style="MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt">
      <div id="FTR">
        <div id="GLFTR" style="WIDTH: 100%" align="left">
        </div>
      </div>
      <div id="PN" style="PAGE-BREAK-AFTER: always">
        <div style="WIDTH: 100%; TEXT-ALIGN: center"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman;">-7-</font></div>
        <div style="WIDTH: 100%; TEXT-ALIGN: center">
          <hr style="COLOR: black" noshade size="2">
        </div>
      </div>
      <div id="HDR">
        <div id="GLHDR" style="WIDTH: 100%" align="right">
        </div>
      </div>
    </div>
    <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt" align="center"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman;"><strong>SIGNATURES</strong></font></div>
    <div><br></div>
    <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 36pt; MARGIN-RIGHT: 0pt" align="left"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman;">Pursuant
      to the requirements of the Securities Act of 1933, the Company certifies that
      it
      has reasonable grounds to believe that it meets all of the requirements for
      filing a Form S-8 and has duly caused this Registration Statement to be signed
      on its behalf by the undersigned, thereunto duly authorized, in the City of
      Newton, Commonwealth of Massachusetts on April 2, 2007.</font></div>
    <div>&#160;</div>
    <div>
      <table border="0" cellpadding="0" cellspacing="0" width="100%">

          <tr>
            <td valign="top" width="50%"><font style="DISPLAY: inline; FONT-SIZE: 10pt;">&#160;</font></td>
            <td colspan="2" valign="top" width="38%">
              <div align="left"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman;">Matritech,
                Inc.</font></div>
            </td>
            <td valign="top" width="12%"><font style="DISPLAY: inline; FONT-SIZE: 10pt;">&#160;</font></td>
          </tr>
          <tr>
            <td valign="top" width="50%"><font style="DISPLAY: inline; FONT-SIZE: 10pt;">&#160;</font></td>
            <td valign="top" width="3%"><font style="DISPLAY: inline; FONT-SIZE: 10pt;">&#160;</font></td>
            <td valign="top" width="35%"><font style="DISPLAY: inline; FONT-SIZE: 10pt;">&#160;</font></td>
            <td valign="top" width="12%"><font style="DISPLAY: inline; FONT-SIZE: 10pt;">&#160;</font></td>
          </tr>
          <tr>
            <td align="left" valign="top" width="50%" style="BORDER-BOTTOM: #ffffff solid">
              <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt" align="left">&#160;</div>
            </td>
            <td valign="top" width="3%" style="BORDER-BOTTOM: #ffffff solid">
              <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt" align="left"><font style="DISPLAY: inline; FONT-SIZE: 10pt;">By:
                </font></div>
            </td>
            <td align="left" nowrap valign="top" width="35%" style="BORDER-BOTTOM: black 2px solid"><font style="DISPLAY: inline; FONT-SIZE: 10pt;">/s/&#160;<font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman;">Stephen
              D. Chubb</font></font></td>
            <td valign="top" width="12%" style="BORDER-BOTTOM: #ffffff solid"><font style="DISPLAY: inline; FONT-SIZE: 10pt;">&#160;</font></td>
          </tr>
          <tr>
            <td valign="top" width="50%"><font style="DISPLAY: inline; FONT-SIZE: 10pt;">&#160;</font></td>
            <td valign="top" width="3%"><font style="DISPLAY: inline; FONT-SIZE: 10pt;">&#160;</font></td>
            <td align="left" nowrap valign="bottom" width="35%">
              <div align="left"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman;">Stephen
                D. Chubb</font></div>
            </td>
            <td valign="top" width="12%"><font style="DISPLAY: inline; FONT-SIZE: 10pt;">&#160;</font></td>
          </tr>
          <tr>
            <td valign="top" width="50%"><font style="DISPLAY: inline; FONT-SIZE: 10pt;">&#160;</font></td>
            <td valign="top" width="3%"><font style="DISPLAY: inline; FONT-SIZE: 10pt;">&#160;</font></td>
            <td valign="top" width="35%">
              <div align="left"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman;">Director,
                Chairman and Chief Executive Officer</font></div>
            </td>
            <td valign="top" width="12%"><font style="DISPLAY: inline; FONT-SIZE: 10pt;">&#160;</font></td>
          </tr>
          <tr>
            <td valign="top" width="50%"><font style="DISPLAY: inline; FONT-SIZE: 10pt;">&#160;</font></td>
            <td valign="top" width="3%"><font style="DISPLAY: inline; FONT-SIZE: 10pt;">&#160;</font></td>
            <td valign="top" width="35%"><font style="DISPLAY: inline; FONT-SIZE: 10pt;">&#160;</font></td>
            <td valign="top" width="12%"><font style="DISPLAY: inline; FONT-SIZE: 10pt;">&#160;</font></td>
          </tr>

      </table><br></div>
    <div>&#160;</div>
    <div>&#160;</div>
    <div>&#160;</div>
    <div>&#160;</div>
    <div>&#160;</div>
    <div>&#160;</div>
    <div>&#160;</div>
    <div>&#160;</div>
    <div>&#160;</div>
    <div>&#160;</div>
    <div>&#160;</div>
    <div>&#160;</div>
    <div id="PGBRK" style="MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt">
      <div id="FTR">
        <div id="GLFTR" style="WIDTH: 100%" align="left">
        </div>
      </div>
      <div id="PN" style="PAGE-BREAK-AFTER: always">
        <div style="WIDTH: 100%; TEXT-ALIGN: center"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman;">-8-</font></div>
        <div style="WIDTH: 100%; TEXT-ALIGN: center">
          <hr style="COLOR: black" noshade size="2">
        </div>
      </div>
      <div id="HDR">
        <div id="GLHDR" style="WIDTH: 100%" align="right">
        </div>
      </div>
    </div>
    <div style="MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt" align="center"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman;"><strong>POWER
      OF ATTORNEY AND SIGNATURES</strong></font></div>
    <div><br></div>
    <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 27pt; MARGIN-RIGHT: 0pt" align="left"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman;">KNOW
      ALL
      MEN BY THESE PRESENTS, that each person whose signature appears below
      constitutes and appoints Stephen D. Chubb his or her true and lawful
      attorney-in-fact and agent, with full power of substitution, for him or her
      and
      in his or her name, place and stead, in any and all capacities, to sign this
      registration statement and any and all amendments (including post-effective
      amendments) hereto, and to file the same with all exhibits thereto, and other
      documents in connection therewith, with the Securities and Exchange Commission,
      granting unto said attorney-in-fact and agent full power and authority to do
      and
      perform each and every act and thing requisite and ratifying and confirming
      all
      that said attorney-in-fact and agent or his substitute or substitutes may
      lawfully do or cause to be done by virtue hereof.</font></div>
    <div><br></div>
    <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 27pt; MARGIN-RIGHT: 0pt" align="left"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman;">Pursuant
      to the requirements of the Securities Act of 1933, this registration statement
      has been signed by the following persons in the capacities and on the dates
      indicated.</font></div>
    <div><br></div>
    <div>
      <div align="left">
        <div align="left">
          <table border="0" cellpadding="0" cellspacing="0" width="100%">

              <tr>
                <td valign="top" width="38%">
                  <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt" align="center"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: times new roman;"><strong><u>Signature</u></strong></font></div>
                </td>
                <td width="2%"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman;">&#160;</font></td>
                <td valign="top" width="38%">
                  <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt" align="center"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: times new roman;"><strong><u>Title</u></strong></font></div>
                </td>
                <td width="2%"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman;">&#160;</font></td>
                <td valign="top" width="20%">
                  <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt" align="center"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: times new roman;"><strong><u>Date</u></strong></font></div>
                </td>
              </tr>
              <tr>
                <td align="left" valign="top" width="38%"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman;">&#160;</font></td>
                <td width="2%"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman;">&#160;</font></td>
                <td valign="top" width="38%"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman;">&#160;</font></td>
                <td width="2%"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman;">&#160;</font></td>
                <td valign="top" width="20%"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman;">&#160;</font></td>
              </tr>
              <tr>
                <td align="left" valign="top" width="38%" style="BORDER-BOTTOM: black 2px solid">
                  <div>&#160;</div>
                  <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt" align="left"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: times new roman;">/s/
                    Stephen D. Chubb</font></div>
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              </tr>
              <tr>
                <td align="left" valign="top" width="38%" style="BORDER-BOTTOM: black">
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              <tr>
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              <tr>
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              </tr>
              <tr>
                <td align="left" valign="top" width="38%" style="BORDER-BOTTOM: black">
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              <tr>
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              <tr>
                <td align="left" valign="top" width="38%" style="BORDER-BOTTOM: black 2px solid">
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                <td width="2%"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman;">&#160;</font></td>
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                </td>
              </tr>
              <tr>
                <td align="left" valign="top" width="38%" style="BORDER-BOTTOM: black">
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              <tr>
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                <td valign="top" width="38%"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: times new roman;">&#160;</font></td>
                <td width="2%"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman;">&#160;</font></td>
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              <tr>
                <td align="left" valign="top" width="38%" style="BORDER-BOTTOM: black 2px solid">
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                    Bruce Lehman</font></div>
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                <td width="2%"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman;">&#160;</font></td>
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                </td>
              </tr>
              <tr>
                <td align="left" valign="top" width="38%" style="BORDER-BOTTOM: black">
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              <tr>
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                <td width="2%"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman;">&#160;</font></td>
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              <tr>
                <td align="left" valign="top" width="38%" style="BORDER-BOTTOM: black 2px solid">
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                <td width="2%"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman;">&#160;</font></td>
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                </td>
              </tr>
              <tr>
                <td align="left" valign="top" width="38%" style="BORDER-BOTTOM: black">
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                <td width="2%"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman;">&#160;</font></td>
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                <td valign="top" width="20%" style="BORDER-BOTTOM: black"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: times new roman;">&#160;</font></td>
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              <tr>
                <td align="left" valign="top" width="38%" style="BORDER-BOTTOM: black 2px solid">
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                </td>
              </tr>
              <tr>
                <td align="left" valign="top" width="38%" style="BORDER-BOTTOM: black">
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                <td width="2%"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman;">&#160;</font></td>
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              <tr>
                <td align="left" valign="top" width="38%" style="BORDER-BOTTOM: black 2px solid">
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                <td width="2%"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman;">&#160;</font></td>
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                </td>
              </tr>
              <tr>
                <td align="left" valign="top" width="38%" style="BORDER-BOTTOM: black">
                  <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt" align="left"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: times new roman;">Robert
                    J. Rosenthal</font></div>
                  <div>&#160;</div>
                </td>
                <td width="2%"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman;">&#160;</font></td>
                <td valign="top" width="38%" style="BORDER-BOTTOM: black"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: times new roman;">&#160;</font></td>
                <td width="2%"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman;">&#160;</font></td>
                <td valign="top" width="20%" style="BORDER-BOTTOM: black"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: times new roman;">&#160;</font></td>
              </tr>
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                <td align="left" valign="top" width="38%" style="BORDER-BOTTOM: black 2px solid">
                  <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt" align="left"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: times new roman;">/s/
                    T. Stephen Thompson</font></div>
                </td>
                <td width="2%"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman;">&#160;</font></td>
                <td valign="top" width="38%" style="BORDER-BOTTOM: black">
                  <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt" align="center"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: times new roman;">Director</font></div>
                </td>
                <td width="2%"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman;">&#160;</font></td>
                <td valign="top" width="20%" style="BORDER-BOTTOM: black">
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                    2, 2007</font></div>
                </td>
              </tr>
              <tr>
                <td align="left" valign="top" width="38%" style="BORDER-BOTTOM: black">
                  <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt" align="left"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: times new roman;">T.
                    Stephen Thompson</font></div>
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                <td width="2%"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman;">&#160;</font></td>
                <td valign="top" width="38%" style="BORDER-BOTTOM: black"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: times new roman;">&#160;</font></td>
                <td width="2%"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman;">&#160;</font></td>
                <td valign="top" width="20%" style="BORDER-BOTTOM: black"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: times new roman;">&#160;</font></td>
              </tr>
              <tr>
                <td align="left" valign="top" width="38%"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: times new roman;">&#160;</font></td>
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                <td valign="top" width="38%"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: times new roman;">&#160;</font></td>
                <td width="2%"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman;">&#160;</font></td>
                <td valign="top" width="20%"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: times new roman;">&#160;</font></td>
              </tr>
              <tr>
                <td align="left" valign="top" width="38%" style="BORDER-BOTTOM: black 2px solid">
                  <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt" align="left"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: times new roman;">/s/
                    C. William Zadel</font></div>
                </td>
                <td width="2%"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman;">&#160;</font></td>
                <td valign="top" width="38%" style="BORDER-BOTTOM: black">
                  <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt" align="center"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: times new roman;">Director</font></div>
                </td>
                <td width="2%"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman;">&#160;</font></td>
                <td valign="top" width="20%" style="BORDER-BOTTOM: black">
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                    2, 2007</font></div>
                </td>
              </tr>
              <tr>
                <td align="left" valign="top" width="38%" style="BORDER-BOTTOM: black">
                  <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt" align="left"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: times new roman;">C.
                    William Zadel</font></div>
                </td>
                <td width="2%"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman;">&#160;</font></td>
                <td valign="top" width="38%" style="BORDER-BOTTOM: black"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: times new roman;">&#160;</font></td>
                <td width="2%"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman;">&#160;</font></td>
                <td valign="top" width="20%" style="BORDER-BOTTOM: black"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: times new roman;">&#160;</font></td>
              </tr>

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    <div>&#160;</div>
    <div><br>&#160;</div>
    <div id="PGBRK" style="MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt">
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        <div style="WIDTH: 100%; TEXT-ALIGN: center">
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      <div id="HDR">
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    <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt" align="left">&#160;</div>
    <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt">
      <table align="center" border="0" cellpadding="0" cellspacing="0" id="hangingindent" width="100%" style="MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt">

          <tr valign="top">
            <td align="left" style="WIDTH: 108pt">
              <div><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman;"><strong><u>Exhibit
                No.</u></strong></font></div>
            </td>
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              <div align="left"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman;"><strong><u>Description
                of Exhibit</u></strong></font></div>
            </td>
          </tr>

      </table>
    </div>
    <div><br></div>
    <div>
      <table align="center" border="0" cellpadding="0" cellspacing="0" id="hangingindent" width="100%">

          <tr valign="top">
            <td style="WIDTH: 108pt">
              <div style="MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt" align="left"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman;">Exhibit
                4.1</font></div>
            </td>
            <td>
              <div align="left"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman;">Specimen
                Common Stock Certificate (originally filed as Exhibit&#160;4.2 to
                Matritech&#8217;s Registration Statement No. 33-46158 on Form&#160;S-1 and
                incorporated herein by reference).</font></div>
            </td>
          </tr>

      </table>
    </div>
    <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt" align="justify">&#160;</div>
    <div>
      <table align="center" border="0" cellpadding="0" cellspacing="0" id="hangingindent" width="100%">

          <tr valign="top">
            <td style="WIDTH: 108pt">
              <div style="MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt" align="left"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman;">Exhibit
                4.2</font></div>
            </td>
            <td>
              <div align="left"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman;">Amended
                and Restated Certificate of Incorporation (originally filed as
                Exhibits&#160;3, 4.1 to Matritech&#8217;s Registration Statement
                No.&#160;33-46158 on Form&#160;S-1 and re-filed in electronic form as
                Exhibit&#160;3.1 to Matritech&#8217;s Annual Report on Form&#160;10-K for the
                fiscal year ended December&#160;31, 2001 and incorporated herein by
                reference).</font></div>
            </td>
          </tr>

      </table>
    </div>
    <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt" align="justify">&#160;</div>
    <div>
      <table align="center" border="0" cellpadding="0" cellspacing="0" id="hangingindent" width="100%">

          <tr valign="top">
            <td style="WIDTH: 108pt">
              <div style="MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt" align="left"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman;">Exhibit
                4.3</font></div>
            </td>
            <td>
              <div align="left"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman;">Amended
                and Restated By-Laws (originally filed as Exhibits&#160;3.2, 4.1 to
                Matritech&#8217;s Registration Statement No.&#160;33-46158 on Form&#160;S-1 and
                re-filed in electronic form as Exhibit&#160;3.2 to Matritech&#8217;s Annual
                Report on Form&#160;10-K for the fiscal year ended December&#160;31, 2001
                and incorporated herein by
                reference).</font></div>
            </td>
          </tr>

      </table>
    </div>
    <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt" align="justify">&#160;</div>
    <div>
      <table align="center" border="0" cellpadding="0" cellspacing="0" id="hangingindent" width="100%">

          <tr valign="top">
            <td style="WIDTH: 108pt">
              <div style="MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt" align="left"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman;">Exhibit
                4.4</font></div>
            </td>
            <td>
              <div align="left"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman;">Certificate
                of Amendment dated June&#160;16, 1994, of Amended and Restated Certificate
                of Incorporation of the Registrant (originally filed as Exhibit&#160;3.2
                of Matritech&#8217;s Quarterly Report on Form&#160;10-Q for the fiscal quarter
                ended June&#160;30, 1995 and re-filed in electronic form as
                Exhibit&#160;3.3 to Matritech&#8217;s Annual Report on Form&#160;10-K for the
                fiscal year ended December&#160;31, 2001 and incorporated herein by
                reference).</font></div>
            </td>
          </tr>

      </table>
    </div>
    <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt" align="justify">&#160;</div>
    <div>
      <table align="center" border="0" cellpadding="0" cellspacing="0" id="hangingindent" width="100%">

          <tr valign="top">
            <td style="WIDTH: 108pt">
              <div style="MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt" align="left"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman;">Exhibit
                4.5</font></div>
            </td>
            <td>
              <div align="left"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman;">Certificate
                of Amendment dated June&#160;5, 1995, of Amended and Restated Certificate
                of Incorporation of the Registrant (originally filed as Exhibit&#160;3.3
                of Matritech&#8217;s Quarterly Report on Form&#160;10-Q for the fiscal quarter
                ended June&#160;30, 1995 and re-filed in electronic form as
                Exhibit&#160;3.4 to Matritech&#8217;s Annual Report on Form&#160;10-K for the
                fiscal year ended December&#160;31, 2001 and incorporated herein by
                reference).</font></div>
            </td>
          </tr>

      </table>
    </div>
    <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt" align="justify">&#160;</div>
    <div>
      <table align="center" border="0" cellpadding="0" cellspacing="0" id="hangingindent" width="100%">

          <tr valign="top">
            <td style="WIDTH: 108pt">
              <div style="MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt" align="left"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman;">Exhibit
                4.6</font></div>
            </td>
            <td>
              <div align="left"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman;">Certificate
                of Amendment dated June&#160;26, 2002, of Amended and Restated Certificate
                of Incorporation of the Company (filed as Exhibit&#160;4.6 to Matritech&#8217;s
                Registration Statement No.&#160;333-96701 on Form&#160;S-8, filed on
                July&#160;18, 2002 and incorporated herein by
                reference).</font></div>
            </td>
          </tr>

      </table>
    </div>
    <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt" align="justify">&#160;</div>
    <div>
      <table align="center" border="0" cellpadding="0" cellspacing="0" id="hangingindent" width="100%">

          <tr valign="top">
            <td style="WIDTH: 108pt">
              <div style="MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt" align="left"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman;">Exhibit
                4.7</font></div>
            </td>
            <td>
              <div align="left"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman;">Certificate
                of Amendment, dated June&#160;11, 2004, of Amended and Restated
                Certificate of Incorporation (filed as Exhibit&#160;3.5 to Matritech&#8217;s
                Quarterly Report on Form&#160;10-Q for the fiscal quarter ended
                June&#160;30, 2004 and incorporated herein by
                reference).</font></div>
            </td>
          </tr>

      </table>
    </div>
    <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt" align="justify">&#160;</div>
    <div>
      <table align="center" border="0" cellpadding="0" cellspacing="0" id="hangingindent" width="100%">

          <tr valign="top">
            <td style="WIDTH: 108pt">
              <div style="MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt" align="left"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman;">Exhibit
                4.8</font></div>
            </td>
            <td>
              <div align="left"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman;">Certificate
                of Amendment dated June 9, 2006 of Amended and Restated Certificate
                of
                Incorporation of the Company (filed as Exhibit 3.1 to Matritech&#8217;s Current
                Report on Form 8-K filed on June 13, 2006 and incorporated herein
                by
                reference).</font></div>
            </td>
          </tr>

      </table>
    </div>
    <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt" align="justify">&#160;</div>
    <div>
      <table align="center" border="0" cellpadding="0" cellspacing="0" id="hangingindent" width="100%">

          <tr valign="top">
            <td style="WIDTH: 108pt">
              <div style="MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt" align="left"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman;">Exhibit
                4.9</font></div>
            </td>
            <td>
              <div align="left"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman;">Certificate
                of Designations, Preferences and Rights of Series&#160;A Convertible
                Preferred Stock, dated March&#160;4, 2005 (filed as Exhibit&#160;4.1 to
                Matritech&#8217;s Current Report on Form&#160;8-K filed on March&#160;8, 2005
                and incorporated herein by
                reference).</font></div>
            </td>
          </tr>

      </table>
    </div>
    <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt" align="justify">&#160;</div>
    <div>
      <table align="center" border="0" cellpadding="0" cellspacing="0" id="hangingindent" width="100%">

          <tr valign="top">
            <td style="WIDTH: 108pt">
              <div style="MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt" align="left"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman;">Exhibit
                4.10</font></div>
            </td>
            <td>
              <div align="left"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman;">Certificate
                of Correction of Certificate of Designations, Preferences and Rights
                of
                Series&#160;A Convertible Preferred Stock (filed as Exhibit&#160;4.1 to
                Matritech&#8217;s Form&#160;8-K/A filed March&#160;25, 2005 and incorporated
                herein by reference)</font></div>
            </td>
          </tr>

      </table>
    </div>
    <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt" align="justify">&#160;</div>
    <div id="PGBRK" style="MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt">
      <div id="FTR">
        <div id="GLFTR" style="WIDTH: 100%" align="left">
        </div>
      </div>
      <div id="PN" style="PAGE-BREAK-AFTER: always">
        <div style="WIDTH: 100%; TEXT-ALIGN: center"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman;">-10-</font></div>
        <div style="WIDTH: 100%; TEXT-ALIGN: center">
          <hr style="COLOR: black" noshade size="2">
        </div>
      </div>
      <div id="HDR">
        <div id="GLHDR" style="WIDTH: 100%" align="right">
        </div>
      </div>
    </div>
    <div>
      <table align="center" border="0" cellpadding="0" cellspacing="0" id="hangingindent" width="100%">

          <tr valign="top">
            <td style="WIDTH: 108pt">
              <div style="MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt" align="left"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman;">Exhibit
                4.11</font></div>
            </td>
            <td>
              <div align="left"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman;">Amendment
                to Certificate of Designations, Preferences and Rights of Series&#160;A
                Preferred Stock (filed as Exhibit&#160;4.1 to Matritech&#8217;s Current Report
                on Form&#160;8-K filed January&#160;17, 2006 and incorporated herein by
                reference).</font></div>
            </td>
          </tr>

      </table>
    </div>
    <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt" align="justify">&#160;</div>
    <div>
      <table align="center" border="0" cellpadding="0" cellspacing="0" id="hangingindent" width="100%">

          <tr valign="top">
            <td style="WIDTH: 108pt">
              <div style="MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt" align="left"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman;">Exhibit
                4.12</font></div>
            </td>
            <td>
              <div align="left"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman;">Amendment
                to Certificate of Designations, Preferences and Rights of Series
                A
                Preferred Stock (filed as Exhibit 4.10 to Matritech&#8217;s Form 8-K filed
                January 24, 2007 and incorporated herein by
                reference).</font></div>
            </td>
          </tr>

      </table>
    </div>
    <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt" align="justify">&#160;</div>
    <div>
      <table align="center" border="0" cellpadding="0" cellspacing="0" id="hangingindent" width="100%">

          <tr valign="top">
            <td style="WIDTH: 108pt">
              <div style="MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt" align="left"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman;">Exhibit
                4.13</font></div>
            </td>
            <td>
              <div align="left"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman;">2006
                Equity and Incentive Plan as amended September 15, 2006 (filed as
                Exhibit
                10.1 to Matritech&#8217;s Form 8-K filed September 19, 2006 and incorporated
                herein by reference).</font></div>
            </td>
          </tr>

      </table>
    </div>
    <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt" align="justify">&#160;</div>
    <div>
      <table align="center" border="0" cellpadding="0" cellspacing="0" id="hangingindent" width="100%">

          <tr valign="top">
            <td style="WIDTH: 108pt">
              <div style="MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt" align="left"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman;">Exhibit
                5.1</font></div>
            </td>
            <td>
              <div align="left"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman;">Opinion
                of Choate, Hall &amp; Stewart LLP.</font></div>
            </td>
          </tr>

      </table>
    </div>
    <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt" align="justify">&#160;</div>
    <div>
      <table align="center" border="0" cellpadding="0" cellspacing="0" id="hangingindent" width="100%">

          <tr valign="top">
            <td style="WIDTH: 108pt">
              <div style="MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt" align="left"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman;">Exhibit
                23.1</font></div>
            </td>
            <td>
              <div align="left"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman;">Consent
                of PricewaterhouseCoopers LLP, an independent registered public accounting
                firm.</font></div>
            </td>
          </tr>

      </table>
    </div>
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                23.2</font></div>
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                of Choate, Hall &amp; Stewart LLP (included in
                Exhibit&#160;5.1).</font></div>
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            </td>
            <td>
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                of Attorney (included as part of the signature page to this Registration
                Statement).</font></div>
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{"company-data": {"conformed-name": "MATRITECH INC/DE/", "cik": "0000884847", "assigned-sic": "2835", "irs-number": "042985132", "state-of-incorporation": "DE", "fiscal-year-end": "1231"}, "filing-values": {"form-type": "S-8", "act": "33", "file-number": "333-141798", "film-number": "07739416"}, "business-address": {"street1": "330 NEVADA ST", "city": "NEWTON", "state": "MA", "zip": "02460", "phone": "6179280820"}, "mail-address": {"street1": "330 NEVADA STREET", "city": "NEWTON", "state": "MA", "zip": "02460"}}
Unassociated Document
As
      filed with the Securities and Exchange Commission on April 2,
      2007
Registration
      No. 333-______
SECURITIES
      AND EXCHANGE COMMISSION
WASHINGTON,
      D.C. 20549
FORM
      S-8
REGISTRATION
      STATEMENT
UNDER
      THE SECURITIES ACT OF 1933
MATRITECH,
      INC.
(Exact
      name of registrant as specified in its charter)
Delaware
04-2985132
(State
                  or other jurisdiction of incorporation or organization)
(I.R.S.
                  Employer Identification No.)
330
      Nevada Street
Newton,
      Massachusetts 02460
(617)
      928-0820
(Address,
      Including Zip Code and Telephone Number, Including Area Code, of Registrant's
      Principal Executive Offices)
2006
      Equity and Incentive Plan
as
      amended September 15, 2006
(Full
      title of the plan)
Stephen
      D. Chubb
Chief
      Executive Officer
MATRITECH,
      INC.
330
      Nevada Street
Newton,  Massachusetts
      02460
(617)
      928-0820
(Name,
      Address, Including Zip Code and Telephone Number, Including Area Code of Agent
      for Service)
Copy
      to:
Barbara
      F. Johnson, Esq.
CHOATE,
      HALL & STEWART LLP
Two
      International Place
Boston,
      MA  02110
(617)
      248-5000
CALCULATION
      OF REGISTRATION FEE
Title
                                                    of Securities to be Registered
Amount
                                                    to be
Registered(1)
Proposed
Maximum
Offering Price
Per
                                                    Share
Proposed
Maximum
Offering
Price
Amount
                                                    of
Registration
Fee(3)
2006
                                                    Equity and Incentive Plan as
                                                    amended September 15, 2006
Common
                                                    Stock, $.01 par value
4,000,000
                                                    shares
$
0.51
(2)
$
2,040,000
$
30.70
(1)
In
                addition, pursuant to Rule 416(a) under the Securities Act of 1933,
                as
                amended (the "Securities Act"), this Registration Statement also covers
                such indeterminate amount of additional shares of Common Stock as
                is
                necessary to eliminate any dilutive effect of any future stock splits,
                stock dividends or similar
                transactions.
(2)
The
                price of $0.51 per share, which is the average of the high and low
                sales
                prices per share of Common Stock on the American Stock Exchange on
                March
                29, 2007 is set forth solely for the purpose of calculating the
                registration fee in accordance with Rule 457(c) under the Securities
                Act
                and has been used only for those shares without a fixed exercise
                price.
(3)
Calculated
                pursuant to Section 6(b) of the Securities Act, as
                amended.
PART I
INFORMATION
      REQUIRED IN THE SECTION 10(A) PROSPECTUS
The
      documents containing the
      information specified in Item 1 and Item 2 of Form S-8 will be
      sent or given to the employees, officers and directors who have been granted
      options, restricted stock, restricted stock units or other awards under the
      2006
      Equity and Incentive Plan as amended September 15,
      2006,
as specified by Rule 428(b)(1) of the Securities
      Act.  In accordance with the rules and regulations of the Securities
      and Exchange Commission (the "SEC") and the instructions to Form S-8, such
      documents are not being filed with the SEC either as part of this Registration
      Statement or as Prospectuses or Prospectus Supplements pursuant to
      Rule 424.
-2-
PART II
INFORMATION
      REQUIRED IN THE REGISTRATION STATEMENT
ITEM 3.  INCORPORATION
      OF DOCUMENTS BY REFERENCE.
The
      following documents filed by Matritech, Inc. ("Matritech" or the "Company") with
      the SEC, File No. 001-12128 are incorporated in this Registration Statement
      by
      reference as of their respective dates:
(a)
Matritech's
                Annual Report on Form 10-K for the fiscal year ended December 31,
                2006,
                filed under the Securities Exchange Act of 1934 (the "Exchange Act') on
                March 27, 2007;
(b)
Matritech's
                Current Reports on Form 8-K filed on January 19, 2007, January 24,
                2007, February 6, 2007, March 1, 2007, March 19, 2007 and March 30,
                2007,
                provided that the information deemed "furnished" in such reports and not
                deemed "filed" is not incorporated herein;
                and
(c)
The
                section entitled "Description of Registrant's Securities to be Registered"
                contained in Matritech's Registration Statement on Form S-1, as
                amended, which was incorporated by reference in Matritech's Registration
                Statement on Form 8-A filed pursuant to Section 12(g) of the Exchange
                Act
                filed with the Commission on March 10, 1992, including any amendment
                or
                report filed for the purpose of updating the description of Matritech's
                common stock.
All
      documents subsequently filed with the SEC by Matritech pursuant to Sections
      13(a), 13(c), 14 and 15(d) of the Exchange Act, prior to the filing of a
      post-effective amendment that indicates that all securities offered herein
      have
      been sold or that deregisters all securities then remaining unsold, shall be
      deemed to be incorporated by reference in this Registration Statement and to
      be
      a part hereof from the date of filing of such documents.
ITEM
      4.  DESCRIPTION OF SECURITIES.
Not
      applicable.
ITEM
      5.  INTEREST OF NAMED EXPERTS AND COUNSEL.
Not
      applicable.
ITEM
      6.  INDEMNIFICATION OF DIRECTORS AND OFFICERS.
Pursuant
      to the provisions of Section 145 of the Delaware General Corporation Law
      ("DGCL") the Company has the power to indemnify certain persons, including its
      officers and directors, under stated circumstances and subject to certain
      limitations, for liabilities incurred in connection with services performed
      in
      good faith for the Company or for other organizations at the request of the
      Company.
Article
      Seventh of the Company's Amended and Restated Certificate of Incorporation, as
      amended, provides that no director of the Company shall be liable for monetary
      damages for breach of fiduciary duty, except to the extent that the DGCL
      prohibits the elimination of liability of directors for breach of fiduciary
      duty.
Article
      Twelfth of the Company's Amended and Restated Certificate of Incorporation, as
      amended, provides that a director or officer of the Company (a) shall be
      indemnified by the Company against all expenses (including attorneys' fees),
      judgments, fines and amounts paid in settlement incurred in connection with
      any
      litigation or other legal proceeding (other than an action by or in the right
      of
      the
-3-
Company)
      brought against him by virtue of his position as a director or officer of the
      Company if he acted in good faith and in a manner he reasonably believed to
      be
      in, or not opposed to, the best interests of the Company, and, with respect
      to
      any criminal action or proceeding, had no reasonable cause to believe his
      conduct was unlawful and (b) shall be indemnified by the Company against all
      expenses (including attorneys' fees) and amounts paid in settlement incurred in
      connection with any action by or in the right of the Company brought against
      him
      by virtue of his position as a director or officer of the Company if he acted
      in
      good faith and in a manner he reasonably believed to be in, or not opposed
      to,
      the best interests of the Company, except that no indemnification shall be
      made
      with respect to any matter as to which such person shall have been adjudged
      to
      be liable to the Company, unless a court determines that despite such
      adjudication but in view of all of the circumstances, he is entitled to
      indemnification of such expenses.
Notwithstanding
      the foregoing, to the extent that a director or officer has been successful,
      on
      the merits or otherwise, including, without limitation, the dismissal of an
      action without prejudice, he is required to be indemnified by the Company
      against all expenses (including attorneys' fees) incurred in connection
      therewith. Expenses shall be advanced to a director or officer at his request,
      provided that he undertakes to repay the amount advanced if it is ultimately
      determined that he is not entitled to indemnification for such
      expenses.
Article
      Twelfth of the Company's Amended and Restated Certificate of Incorporation, as
      amended, further provides that the indemnification provided therein is not
      exclusive and provides that in the event that the DGCL is amended to expand
      or
      limit the indemnification permitted to directors or officers, the Company must
      indemnify those persons to the fullest extent permitted by such law, as so
      amended.
In
      addition to the indemnification provided by Section 145 of the DGCL, the Company
      has entered into an Indemnity Agreement with each of its directors pursuant
      to
      which the Company agrees to indemnify that director for (1) all expenses,
      liabilities, judgments, fines and amounts paid in settlement actually and
      reasonably incurred in connection with any legal action, suit or proceeding
      against the director by reason of the fact that he was an agent of the Company
      if he acted in good faith and in a manner he reasonably believed to be in or
      not
      opposed to the best interests of the Company, and with respect to any criminal
      proceedings had no reasonable cause to believe his conduct was unlawful, and
      (2)
      all expenses incurred in connection with the investigation, defense, settlement
      or appeal of any legal action or proceeding brought against the director by
      or
      in the right of the Company by reason of any action taken or not taken by him
      in
      his capacity as a director of the Company if he acted in good faith and in
      a
      manner he reasonably believed to be in or not opposed to the best interests
      of
      the Company. The Company is not obligated under the terms of the Indemnity
      Agreements to indemnify its directors (a) for expenses or liabilities paid
      directly to the directors by directors' and officers' insurance, (b) on account
      of any claims against the directors for an accounting of profits made from
      the
      purchase or sale by directors of securities of the Company pursuant to Section
      16(b) of the Exchange Act, as amended, (c) if indemnification would not be
      lawful.
The
      Company also maintains directors' and officers' liability insurance to insure
      its directors and certain officers against certain liabilities and expenses
      that
      arise out of or in connection with their capacities as directors and
      officers.
ITEM
      7.  EXEMPTION FROM REGISTRATION CLAIMED.
Not
      applicable.
-4-
ITEM
      8.  EXHIBITS
Exhibit
                No.
Description
                of Exhibit
Exhibit
                4.1
Specimen
                Common Stock Certificate (originally filed as Exhibit 4.2 to
                Matritech's Registration Statement No. 33-46158 on Form S-1 and
                incorporated herein by reference).
Exhibit
                4.2
Amended
                and Restated Certificate of Incorporation (originally filed as
                Exhibits 3, 4.1 to Matritech's Registration Statement
                No. 33-46158 on Form S-1 and re-filed in electronic form as
                Exhibit 3.1 to Matritech's Annual Report on Form 10-K for the
                fiscal year ended December 31, 2001 and incorporated herein by
                reference).
Exhibit
                4.3
Amended
                and Restated By-Laws (originally filed as Exhibits 3.2, 4.1 to
                  Matritech's Registration Statement No. 33-46158 on Form S-1 and
                re-filed in electronic form as Exhibit 3.2 to Matritech's Annual
                Report on Form 10-K for the fiscal year ended December 31, 2001
                and incorporated herein by
                reference).
Exhibit
                4.4
Certificate
                of Amendment dated June 16, 1994, of Amended and Restated Certificate
                of Incorporation of the Registrant (originally filed as Exhibit 3.2
                of Matritech's Quarterly Report on Form 10-Q for the fiscal quarter
                ended June 30, 1995 and re-filed in electronic form as
                Exhibit 3.3 to Matritech's Annual Report on Form 10-K for the
                fiscal year ended December 31, 2001 and incorporated herein by
                reference).
Exhibit
                4.5
Certificate
                of Amendment dated June 5, 1995, of Amended and Restated Certificate
                of Incorporation of the Registrant (originally filed as Exhibit 3.3
                of Matritech's Quarterly Report on Form 10-Q for the fiscal quarter
                ended June 30, 1995 and re-filed in electronic form as
                Exhibit 3.4 to Matritech's Annual Report on Form 10-K for the
                fiscal year ended December 31, 2001 and incorporated herein by
                reference).
Exhibit
                4.6
Certificate
                of Amendment dated June 26, 2002, of Amended and Restated Certificate
                of Incorporation of the Company (filed as Exhibit 4.6 to Matritech's
                Registration Statement No. 333-96701 on Form S-8, filed on
                July 18, 2002 and incorporated herein by
                reference).
Exhibit
                4.7
Certificate
                of Amendment, dated June 11, 2004, of Amended and Restated
                Certificate of Incorporation (filed as Exhibit 3.5 to Matritech's
                Quarterly Report on Form 10-Q for the fiscal quarter ended
                June 30, 2004 and incorporated herein by
                reference).
Exhibit
                4.8
Certificate
                of Amendment dated June 9, 2006 of Amended and Restated Certificate
                of
                Incorporation of the Company (filed as Exhibit 3.1 to Matritech's Current
                Report on Form 8-K filed on June 13, 2006 and incorporated herein
                by
                reference).
Exhibit
                4.9
Certificate
                of Designations, Preferences and Rights of Series A Convertible
                Preferred Stock, dated March 4, 2005 (filed as Exhibit 4.1 to
                Matritech's Current Report on Form 8-K filed on March 8, 2005
                and incorporated herein by
                reference).
Exhibit
                4.10
Certificate
                of Correction of Certificate of Designations, Preferences and Rights
                of
                Series A Convertible Preferred Stock (filed as Exhibit 4.1 to
                Matritech's Form 8-K/A filed March 25, 2005 and incorporated
                herein by reference)
-5-
Exhibit
                4.11
Amendment
                to Certificate of Designations, Preferences and Rights of Series A
                Preferred Stock (filed as Exhibit 4.1 to Matritech's Current Report
                on Form 8-K filed January 17, 2006 and incorporated herein by
                reference).
Exhibit
                4.12
Amendment
                to Certificate of Designations, Preferences and Rights of Series
                A
                Preferred Stock (filed as Exhibit 4.10 to Matritech's Form 8-K filed
                January 24, 2007 and incorporated herein by
                reference).
Exhibit
                4.13
2006
                Equity and Incentive Plan as amended September 15, 2006 (filed as
                Exhibit
                10.1 to Matritech's Form 8-K filed September 19, 2006 and incorporated
                herein by reference).
Exhibit
                5.1
Opinion
                of Choate, Hall & Stewart LLP.
Exhibit
                23.1
Consent
                of PricewaterhouseCoopers LLP, an independent registered public accounting
                firm.
Exhibit
                23.2
Consent
                of Choate, Hall & Stewart LLP (included in
                Exhibit 5.1).
Exhibit
                24.1
Power
                of Attorney (included as part of the signature page to this Registration
                Statement).
ITEM
      9.  UNDERTAKINGS.
(a)
Matritech
                hereby undertakes:
(1)
To
                file, during any period in which offers or sales are being made,
                a
                post-effective amendment to this Registration
                Statement:
(i)
To
                include any Prospectus required by Section 10(a)(3) of the Securities
                Act;
(ii)
To
                reflect in the Prospectus any facts or events arising after the effective
                date of the Registration Statement (or the most recent post-effective
                amendment thereof) which, individually or in the aggregate, represent
                a
                fundamental change in the information set forth in the Registration
                Statement. Notwithstanding the foregoing, any increase or decrease
                in
                volume of securities offered (if the total dollar value of securities
                offered would not exceed that which was registered) and any deviation
                from
                the low or high and of the estimated maximum offering range may be
                reflected in the form of Prospectus filed with the SEC pursuant to
                Rule
                424(b) if, in the aggregate, the changes in volume and price represent
                no
                more than 20 percent change in the maximum aggregate offering price
                set
                forth in the "Calculation of Registration Fee" table in the effective
                Registration Statement.
(iii)
To
                include any additional or changed material information with respect
                to the
                plan of distribution not previously disclosed in the Registration
                Statement or any material change to such information in the Registration
                Statement.
provided,
      however
, that paragraphs (a)(1)(i) and (a)(1)(ii) do not apply if
      the information required to be included in a post-effective amendment by those
      paragraphs is contained in reports filed with or furnished to the SEC by
      Matritech pursuant to Section 13 or Section 15(d) of the Exchange Act
      of 1934 that are incorporated by reference in the registration
      statement.
(2)
That,
                for the purpose of determining any liability under the Securities
                Act,
                each such post-effective amendment shall be deemed to be a new
                Registration Statement relating to the securities offered therein,
                and the
                offering of such securities at that time shall be deemed to be the
                initial
                bona fide offering thereof.
(3)
To
                remove from registration by means of a post-effective amendment any
                of the
                securities being registered which remain unsold at the termination
                of the
                offering.
-6-
(b)
Matritech
                hereby undertakes that, for purposes of determining any liability
                under
                the Securities Act, each filing of Matritech's annual report pursuant to
                Section 13(a) or Section 15(d) of the Exchange Act (and, where
                applicable, each filing of an employee benefit plan's annual report
                pursuant to Section 15(d) of the Exchange Act) that is incorporated
                by reference in the Registration Statement shall be deemed to be
                a new
                Registration Statement relating to the securities offered therein,
                and the
                offering of such securities at that time shall be deemed to be the
                initial
                bona fide offering thereof.
(c)
Insofar
                as indemnification for liabilities arising under the Securities Act
                may be
                permitted to directors, officers and controlling persons of Matritech
                pursuant to the provisions described in Item 6, or otherwise,
                Matritech has been advised that in the opinion of the SEC such
                indemnification is against public policy as expressed in the Act
                and is,
                therefore, unenforceable.  In the event that a claim for
                indemnification against such liabilities (other than the payment
                by
                Matritech of expenses incurred or paid by a director, officer or
                controlling person of Matritech in the successful defense of any
                action,
                suit or proceeding) is asserted by such director, officer or controlling
                person in connection with the securities being registered, Matritech
                will,
                unless in the opinion of its counsel the matter has been settled
                by
                controlling precedent, submit to a court of appropriate jurisdiction
                the
                question whether such indemnification by it is against public policy
                as
                expressed in the Act and will be governed by the final adjudication
                of
                such issue.
-7-
SIGNATURES
Pursuant
      to the requirements of the Securities Act of 1933, the Company certifies that
      it
      has reasonable grounds to believe that it meets all of the requirements for
      filing a Form S-8 and has duly caused this Registration Statement to be signed
      on its behalf by the undersigned, thereunto duly authorized, in the City of
      Newton, Commonwealth of Massachusetts on April 2, 2007.
Matritech,
                Inc.
By:
/s/
Stephen
              D. Chubb
Stephen
                D. Chubb
Director,
                Chairman and Chief Executive Officer
-8-
POWER
      OF ATTORNEY AND SIGNATURES
KNOW
      ALL
      MEN BY THESE PRESENTS, that each person whose signature appears below
      constitutes and appoints Stephen D. Chubb his or her true and lawful
      attorney-in-fact and agent, with full power of substitution, for him or her
      and
      in his or her name, place and stead, in any and all capacities, to sign this
      registration statement and any and all amendments (including post-effective
      amendments) hereto, and to file the same with all exhibits thereto, and other
      documents in connection therewith, with the Securities and Exchange Commission,
      granting unto said attorney-in-fact and agent full power and authority to do
      and
      perform each and every act and thing requisite and ratifying and confirming
      all
      that said attorney-in-fact and agent or his substitute or substitutes may
      lawfully do or cause to be done by virtue hereof.
Pursuant
      to the requirements of the Securities Act of 1933, this registration statement
      has been signed by the following persons in the capacities and on the dates
      indicated.
Signature
Title
Date
/s/
                    Stephen D. Chubb
Director,
                    Chairman and Chief Executive
Officer
                    (Principal Executive Officer)
April
                    2, 2007
Stephen
                    D. Chubb
/s/
                    David L. Corbet
Director,
                    President and Chief Operating Officer
April
                    2, 2007
David
                    L. Corbet
/s/
                    Richard A. Sandberg
Director
                    and Chief Financial Officer,
(Principal
                    Financial and Accounting Officer)
April
                    2, 2007
Richard
                    A. Sandberg
/s/
                    Walter O. Fredericks
Director
April
                    2, 2007
Walter
                    O. Fredericks
/s/
                    Judith Kurland
Director
April
                    2, 2007
Judith
                    Kurland
/s/
                    Bruce Lehman
Director
April
                    2, 2007
Bruce
                    Lehman
/s/
                    David B. Musket
Director
April
                    2, 2007
David
                    B. Musket
/s/
                    Jonathan M. Niloff
Director
April
                    2, 2007
Jonathan
                    M. Niloff
/s/
                    Robert J. Rosenthal
Director
April
                    2, 2007
Robert
                    J. Rosenthal
/s/
                    T. Stephen Thompson
Director
April
                    2, 2007
T.
                    Stephen Thompson
/s/
                    C. William Zadel
Director
April
                    2, 2007
C.
                    William Zadel
-9-
Exhibit
                No.
Description
                of Exhibit
Exhibit
                4.1
Specimen
                Common Stock Certificate (originally filed as Exhibit 4.2 to
                Matritech's Registration Statement No. 33-46158 on Form S-1 and
                incorporated herein by reference).
Exhibit
                4.2
Amended
                and Restated Certificate of Incorporation (originally filed as
                Exhibits 3, 4.1 to Matritech's Registration Statement
                No. 33-46158 on Form S-1 and re-filed in electronic form as
                Exhibit 3.1 to Matritech's Annual Report on Form 10-K for the
                fiscal year ended December 31, 2001 and incorporated herein by
                reference).
Exhibit
                4.3
Amended
                and Restated By-Laws (originally filed as Exhibits 3.2, 4.1 to
                Matritech's Registration Statement No. 33-46158 on Form S-1 and
                re-filed in electronic form as Exhibit 3.2 to Matritech's Annual
                Report on Form 10-K for the fiscal year ended December 31, 2001
                and incorporated herein by
                reference).
Exhibit
                4.4
Certificate
                of Amendment dated June 16, 1994, of Amended and Restated Certificate
                of Incorporation of the Registrant (originally filed as Exhibit 3.2
                of Matritech's Quarterly Report on Form 10-Q for the fiscal quarter
                ended June 30, 1995 and re-filed in electronic form as
                Exhibit 3.3 to Matritech's Annual Report on Form 10-K for the
                fiscal year ended December 31, 2001 and incorporated herein by
                reference).
Exhibit
                4.5
Certificate
                of Amendment dated June 5, 1995, of Amended and Restated Certificate
                of Incorporation of the Registrant (originally filed as Exhibit 3.3
                of Matritech's Quarterly Report on Form 10-Q for the fiscal quarter
                ended June 30, 1995 and re-filed in electronic form as
                Exhibit 3.4 to Matritech's Annual Report on Form 10-K for the
                fiscal year ended December 31, 2001 and incorporated herein by
                reference).
Exhibit
                4.6
Certificate
                of Amendment dated June 26, 2002, of Amended and Restated Certificate
                of Incorporation of the Company (filed as Exhibit 4.6 to Matritech's
                Registration Statement No. 333-96701 on Form S-8, filed on
                July 18, 2002 and incorporated herein by
                reference).
Exhibit
                4.7
Certificate
                of Amendment, dated June 11, 2004, of Amended and Restated
                Certificate of Incorporation (filed as Exhibit 3.5 to Matritech's
                Quarterly Report on Form 10-Q for the fiscal quarter ended
                June 30, 2004 and incorporated herein by
                reference).
Exhibit
                4.8
Certificate
                of Amendment dated June 9, 2006 of Amended and Restated Certificate
                of
                Incorporation of the Company (filed as Exhibit 3.1 to Matritech's Current
                Report on Form 8-K filed on June 13, 2006 and incorporated herein
                by
                reference).
Exhibit
                4.9
Certificate
                of Designations, Preferences and Rights of Series A Convertible
                Preferred Stock, dated March 4, 2005 (filed as Exhibit 4.1 to
                Matritech's Current Report on Form 8-K filed on March 8, 2005
                and incorporated herein by
                reference).
Exhibit
                4.10
Certificate
                of Correction of Certificate of Designations, Preferences and Rights
                of
                Series A Convertible Preferred Stock (filed as Exhibit 4.1 to
                Matritech's Form 8-K/A filed March 25, 2005 and incorporated
                herein by reference)
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Exhibit
                4.11
Amendment
                to Certificate of Designations, Preferences and Rights of Series A
                Preferred Stock (filed as Exhibit 4.1 to Matritech's Current Report
                on Form 8-K filed January 17, 2006 and incorporated herein by
                reference).
Exhibit
                4.12
Amendment
                to Certificate of Designations, Preferences and Rights of Series
                A
                Preferred Stock (filed as Exhibit 4.10 to Matritech's Form 8-K filed
                January 24, 2007 and incorporated herein by
                reference).
Exhibit
                4.13
2006
                Equity and Incentive Plan as amended September 15, 2006 (filed as
                Exhibit
                10.1 to Matritech's Form 8-K filed September 19, 2006 and incorporated
                herein by reference).
Exhibit
                5.1
Opinion
                of Choate, Hall & Stewart LLP.
Exhibit
                23.1
Consent
                of PricewaterhouseCoopers LLP, an independent registered public accounting
                firm.
Exhibit
                23.2
Consent
                of Choate, Hall & Stewart LLP (included in
                Exhibit 5.1).
Exhibit
                24.1
Power
                of Attorney (included as part of the signature page to this Registration
                Statement).
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