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<p align="center"><strong> As filed with the Securities and Exchange Commission on March 1, 2010</strong> </p>
<p align="right"><strong> Registration Statement No. 333- ______</strong><br>
</p>
<p align="left">_____________________________________________________________________________________________ </p>
<p align="center"><strong>UNITED STATES</strong></p>
<p align="center"><strong> SECURITIES AND EXCHANGE COMMISSION</strong></p>
<p align="center"><strong> Washington</strong><strong> , D.C. 20549</strong><strong></strong></p>
<p align="center"> <strong>FORM S-8 </strong></p>
<p align="center"><strong> REGISTRATION STATEMENT </strong></p>
<p align="center"><strong> Under </strong></p>
<p align="center"><strong> THE SECURITIES ACT OF 1933 </strong></p>
<p align="center"><strong> PFIZER INC. </strong></p>
<p align="center">(Exact name of Registrant as specified in its charter) </p>
<table cellspacing="0" cellpadding="0">
  <tr>
    <td width="356" valign="top"><p align="center"><strong> DELAWARE </strong></p></td>
    <td width="350" valign="top"><p align="center"><strong> 13-5315170 </strong></p></td>
  </tr>
  <tr>
    <td width="356" valign="top"><p align="center"><strong> (State of Incorporation) </strong></p></td>
    <td width="350" valign="top"><p align="center"><strong> (I.R.S. Employer Identification No.) </strong></p></td>
  </tr>
</table>
<p align="center"><strong> </strong><strong> 235 EAST 42ND STREET </strong></p>
<p align="center"><strong> NEW YORK, NEW YORK 10017-5755 </strong></p>
<p align="center"> (Address of Principal Executive Offices)  </p>
<p align="center"><strong> Pfizer Inc. </strong><br>
<strong>2004 Stock Plan, As Amended and Restated </strong></p>
<p align="center"> (Full Title of the Plan) </p>
<p align="center"><strong>Matthew Lepore, Esq. </strong></p>
<p align="center"><strong> Pfizer Inc. </strong></p>
<p align="center"><strong> 235 East 42nd Street </strong></p>
<p align="center"><strong> New York, New York 10017-5755 </strong></p>
<p align="center"> (Name and Address of Agent for Service) </p>
<p align="center"><strong> (212) 733-2323 </strong></p>
<p align="center"> (Telephone Number, including area code, of Agent for Service) </p>
<p align="left">&nbsp;Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, a non&#8209;accelerated filer, or a smaller reporting company. See the definitions of &ldquo;large accelerated filer,&rdquo; &ldquo;accelerated filer&rdquo; and &ldquo;smaller reporting company&rdquo; in Rule 12b&#8209;2 of the Exchange Act. (Check one): </p>
<table cellspacing="0" cellpadding="0">
  <tr>
    <td width="165" valign="top"><p> Large accelerated filer |X|</p></td>
    <td width="109" valign="top"><p> Accelerated filer </p></td>
    <td width="213" valign="top"><p> Non&#8209;accelerated filer <br>
        (Do not check if a smaller reporting company) </p></td>
    <td width="240" valign="top"><p> Smaller reporting company </p></td>
  </tr>
</table>
<p align="left">&nbsp;</p>
<table cellspacing="0" cellpadding="0">
  <tr>
    <td width="720" colspan="5" valign="top"><p align="center"><strong> CALCULATION OF REGISTRATION FEE </strong></p></td>
  </tr>
  <tr>
    <td width="143" valign="top"><p align="center"><strong> Title of Securities to be Registered </strong></p></td>
    <td width="143" valign="top"><p align="center"><strong> Amount to be Registered</strong></p></td>
    <td width="141" valign="top"><p align="center"><strong> Proposed Maximum Offering Price Per Share</strong>(1) </p></td>
    <td width="141" valign="top"><p align="center"><strong> Proposed Maximum Aggregate Offering Price</strong>(1) </p></td>
    <td width="152" valign="top"><p align="center"><strong> Amount of Registration Fee</strong>(1)</p></td>
  </tr>
  <tr>
    <td width="143" height="57" valign="top"><p> Common Stock, $.05 par value </p></td>
    <td width="143" valign="bottom"><p align="center">&nbsp;</p>
        <p align="center">425,000,000 shares</p></td>
    <td width="141" valign="bottom"><p align="center"> $17.81</p></td>
    <td width="141" valign="bottom"><p align="center"> $7,569,250,000</p></td>
    <td width="152" valign="bottom"><p align="center"> $539,687.52</p></td>
  </tr>
</table>
<p>(1)&nbsp;&nbsp;Calculated in accordance  with Rule 457(c) and Rule 457(h)(1) under the Securities Act of 1933, as  amended (the &ldquo;Securities Act&rdquo;), solely for the purpose of calculating the  registration fee. The offering price per share is based on the average of the  high and the low prices per share of Pfizer Inc. Common Stock on February 24,  2010, which was $17.81, as reported on the New York Stock Exchange.&nbsp; In addition, pursuant to Rule 416(a) under  the Securities Act, this Registration Statement covers any additional shares of  such Common Stock that become issuable pursuant to terms of the Pfizer Inc.  2004 Stock Plan, as Amended and Restated, providing for an increase in the  amount of shares of such Common Stock to be issued thereunder as a result of a  stock dividend, stock split, recapitalization or any other similar transaction.</p>
<p>&nbsp;</p>
<p align="center"><strong>INTRODUCTION </strong></p>
<p>This Registration Statement  on Form S-8 is filed with the Securities and Exchange Commission (the  &ldquo;Commission&rdquo;) by Pfizer Inc., a Delaware corporation (the &ldquo;Company&rdquo;), relating  to the registration of 425,000,000 shares (the &ldquo;Shares&rdquo;) of Company&rsquo;s Common  Stock, par value $.05 per share (the &ldquo;Common Stock&rdquo;), to be offered under the  Pfizer Inc. 2004 Stock Plan (the &ldquo;Plan&rdquo;), as amended and restated. The Shares  are being registered in addition to the Common Stock previously registered for  issuance on the Company&rsquo;s Registration Statement on Form S&minus;8 concerning the  Plan filed with the Commission on April 26, 2004 (Reg. No. 333&minus;114852) (the  &ldquo;2004 Registration Statement&rdquo;).&nbsp; Pursuant  to General Instruction E to Form S&minus;8, the contents of the 2004 Registration  Statement are incorporated by reference herein, except to the extent  supplemented, amended or superseded by the information set forth herein.</p>
<p align="center">&nbsp;</p>
<p align="center"> &nbsp;<strong> &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; </strong><strong>PART II. </strong></p>
<p align="center"><strong> INFORMATION REQUIRED IN THE REGISTRATION STATEMENT </strong></p>
<p><strong>ITEM 3. INCORPORATION OF  DOCUMENTS BY REFERENCE</strong><br>
  <br>
The following documents filed with  the Commission are hereby incorporated by reference in this Registration  Statement:</p>
<ul>
  <li>the Company&rsquo;s Annual  Report on Form 10-K for the year ended December 31, 2009;</li>
  <li>all other reports  filed under Sections 13(a) or 15(d) of the Securities Exchange Act of 1934, as  amended (the &ldquo;Exchange Act&rdquo;), since the end of the fiscal year covered by the  financial statements included in the Company&rsquo;s most recent Annual Report on  Form 10-K; and</li>
  <li>the description of the  Common Stock contained in the Company&rsquo;s Registration Statement filed under  Section 12 of the Exchange Act on March 1, 2004, including all amendments and  reports updating such description.</li>
</ul>
<p>All documents filed by the Company under Section  13(a), 13(c), 14, and 15(d) of the Exchange Act after the date of this  Registration Statement and prior to the filing of a post-effective amendment to  this Registration Statement indicating that all securities offered have been  sold or that deregisters the distribution of all securities then remaining  unsold, will be deemed to be incorporated by reference into this Registration  Statement and will be a part of this Registration Statement from the date that  document is filed.&nbsp; Any statement contained in a document incorporated or  deemed to be incorporated by reference herein shall be deemed to be modified or  superseded for the purposes of this Registration Statement to the extent that a  statement contained in this Registration Statement or in any other subsequently  filed document that also is or is deemed to be incorporated by reference herein  modifies or supersedes such statement.&nbsp; Any statement so modified or  superseded shall not be deemed, except as so modified or superseded, to  constitute a part of this Registration Statement.&nbsp; The Company&rsquo;s Exchange  Act file number with the Commission is 001-03619.</p>
<p><strong>ITEM 5. INTERESTS OF NAMED EXPERTS AND COUNSEL </strong></p>
<p><strong> </strong>The validity of the  securities has been passed upon by Matthew Lepore, Esq., Vice President, Chief Counsel  &ndash; Corporate Governance, and Assistant General Counsel of the Company.&nbsp; Mr. Lepore beneficially owns Common Stock and  options to purchase Common Stock granted under the Plan.</p>
<p>&nbsp;</p>
<p align="left"><strong>ITEM 8. EXHIBITS </strong></p>
<table cellspacing="0" cellpadding="0">
  <tr>
    <td width="121"><p><strong> <u>Exhibit Number </u></strong></p></td>
    <td width="596"><p><strong> <u>Exhibit </u></strong></p></td>
  </tr>
  <tr>
    <td width="121"><p> 5.1 </p></td>
    <td width="596"><p> Opinion of Matthew Lepore, Esq., Vice President, Chief Counsel &ndash; Corporate Governance, and Assistant General Counsel of the Company* </p></td>
  </tr>
  <tr>
    <td width="121"><p> 23(i)&nbsp;&nbsp; </p></td>
    <td width="596"><p> Consent of Matthew Lepore, Esq., Vice President, Chief Counsel &ndash; Corporate Governance, and Assistant General Counsel of the Company (included in Exhibit 5.1)* </p></td>
  </tr>
  <tr>
    <td width="121"><p> 23(ii)&nbsp; </p></td>
    <td width="596"><p> Consent of KPMG LLP, Independent Registered Public Accounting Firm of the Company* </p></td>
  </tr>
  <tr>
    <td width="121"><p> 24&nbsp; &nbsp;&nbsp;&nbsp; </p></td>
    <td width="596"><p> Power of Attorney (included on signature page(s) to this Registration Statement)* </p></td>
  </tr>
</table>
<p><strong> &nbsp;</strong>________________ </p>
<p> * Filed herewith </p>
<p>_______________________________________________________________________________________________________<br>
</p>
<p align="center"><strong>SIGNATURES </strong></p>
<p>Pursuant to the requirements of the Securities  Act of 1933, the Registrant certifies that it has reasonable grounds to believe  that it meets all of the requirements for filing on Form S-8 and has duly  caused this Registration Statement to be signed on its behalf by the  undersigned, thereunto duly authorized, in the City of New York, State of New  York, on the 25th day of February, 2010.</p>
<table width="85%" cellpadding="0" cellspacing="0">
  <tr>
    <td width="56%"><p>&nbsp;</p></td>
    <td width="44%"><p>&nbsp;</p></td>
  </tr>
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    <td><p>&nbsp;</p></td>
    <td><p> PFIZER INC. </p>
        <p> By <u>/s/Jeffrey B. Kindler</u><br>
&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Jeffrey B. Kindler <br>
&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Chairman of the Board, Chief<br>
&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Executive Officer and Director<br>
&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(Principal Executive Officer) </p></td>
  </tr>
  <tr>
    <td><p>&nbsp;</p></td>
    <td><p>&nbsp;</p></td>
  </tr>
</table>
<p>Each person whose signature appears below hereby  constitutes and appoints Amy W. Schulman and Matthew Lepore and each of them  his or her true and lawful attorneys-in-fact and agents, with full power of  substitution and resubstitution, for him or her and in his or her name, place  and stead, in any and all capacities, to sign any and all amendments (including  post-effective amendments) and supplements to this Registration Statement, and  to file the same, with all exhibits thereto, and other documents in connection  therewith, with the Securities and Exchange Commission, and hereby grants to  such attorneys-in-fact and agents full power and authority to do and perform  each and every act and thing requisite and necessary to be done, as fully to  all intents and purposes as he or she might or could do in person, hereby  ratifying and confirming all that said attorneys-in-fact and agents, or either  of them, or their or his or her substitute or substitutes, may lawfully do or  cause to be done by virtue hereof.</p>
<p> Pursuant to the requirements of the Securities Act of 1933, this Registration Statement has been signed below by the following persons in the capacities and on the dates indicated. </p>
<table width="93%" cellpadding="0" cellspacing="0">
  <tr>
    <td width="36%" valign="bottom"><p>&nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp;<strong>SIGNATURE</strong></p></td>
    <td width="4%" valign="bottom"><p>&nbsp; </p></td>
    <td width="34%" valign="bottom"><p align="center"><strong>TITLE</strong></p>
      </td>
    <td width="4%" valign="bottom"><p>&nbsp; </p></td>
    <td colspan="5" valign="bottom"><p align="center"><strong>DATE</strong></p></td>
    <td width="7%"></td>
  </tr>
  <tr>
    <td width="36%" valign="bottom"><p>&nbsp; </p></td>
    <td width="4%" valign="bottom"><p>&nbsp; </p></td>
    <td width="34%" valign="bottom"><p>Chairman of the Board, Chief </p></td>
    <td width="4%" valign="bottom"><p>&nbsp; </p></td>
    <td width="6%" valign="bottom"><p>&nbsp; </p></td>
    <td width="1%" valign="bottom"><p>&nbsp; </p></td>
    <td colspan="4" valign="bottom"><p>&nbsp; </p></td>
  </tr>
  <tr>
    <td width="36%" valign="bottom"><p>&nbsp; </p></td>
    <td width="4%" valign="bottom"><p>&nbsp; </p></td>
    <td width="34%" valign="bottom"><p>Executive Officer and Director </p></td>
    <td width="4%" valign="bottom"><p>&nbsp; </p></td>
    <td colspan="5" valign="bottom"><p>February 25, 2010</p></td>
    <td width="7%"></td>
  </tr>
  <tr>
    <td><p> <u>/s/Jeffrey B. Kindler </u></p></td>
    <td><p>&nbsp; </p></td>
    <td><p>(Principal Executive Officer) </p></td>
    <td width="4%"><p>&nbsp; </p></td>
    <td width="6%"><p>&nbsp; </p></td>
    <td width="1%"><p>&nbsp; </p></td>
    <td colspan="3"><p>&nbsp; </p></td>
    <td width="7%"></td>
  </tr>
  <tr>
    <td width="36%" valign="bottom"><p>(Jeffrey B. Kindler) </p></td>
    <td width="4%" valign="bottom"><p>&nbsp; </p></td>
    <td width="34%" valign="bottom"><p>&nbsp;</p></td>
    <td width="4%" valign="bottom"><p>&nbsp; </p></td>
    <td width="6%" valign="bottom"><p>&nbsp; </p></td>
    <td width="1%" valign="bottom"><p>&nbsp; </p></td>
    <td colspan="3" valign="bottom"><p>&nbsp; </p></td>
    <td width="7%"></td>
  </tr>
  <tr>
    <td colspan="9"><p>&nbsp; </p></td>
    <td width="7%"></td>
  </tr>
  <tr>
    <td width="36%" valign="bottom"><p>&nbsp; </p></td>
    <td width="4%" valign="bottom"><p>&nbsp; </p></td>
    <td width="34%" rowspan="4"><p>Senior Vice President and <br>
        Chief Financial Officer <br>
        (Principal Financial Officer) &nbsp;</p></td>
    <td width="4%" valign="bottom"><p>&nbsp; </p></td>
    <td width="6%" valign="bottom"><p>&nbsp; </p></td>
    <td width="1%" valign="bottom"><p>&nbsp; </p></td>
    <td colspan="3" valign="bottom"><p>&nbsp; </p></td>
    <td width="7%"></td>
  </tr>
  <tr>
    <td width="36%" valign="bottom"><p>&nbsp; </p></td>
    <td width="4%" valign="bottom"><p>&nbsp; </p></td>
    <td width="4%" valign="bottom"><p>&nbsp; </p></td>
    <td colspan="5" valign="bottom"><p>February 25, 2010</p></td>
    <td width="7%"></td>
  </tr>
  <tr>
    <td><p> <u>/s/Frank A. D&rsquo;Amelio </u></p></td>
    <td><p>&nbsp; </p></td>
    <td width="4%"><p>&nbsp; </p></td>
    <td width="6%"><p>&nbsp; </p></td>
    <td width="1%"><p>&nbsp; </p></td>
    <td colspan="3"><p>&nbsp; </p></td>
    <td width="7%"></td>
  </tr>
  <tr>
    <td width="36%" valign="bottom"><p>(Frank A. D&rsquo;Amelio) </p></td>
    <td width="4%" valign="bottom"><p>&nbsp; </p></td>
    <td width="4%" valign="bottom"><p>&nbsp; </p></td>
    <td width="6%" valign="bottom"><p>&nbsp; </p></td>
    <td width="1%" valign="bottom"><p>&nbsp; </p></td>
    <td colspan="3" valign="bottom"><p>&nbsp; </p></td>
    <td width="7%"></td>
  </tr>
  <tr>
    <td colspan="9"><p>&nbsp; </p></td>
    <td width="7%"></td>
  </tr>
  <tr>
    <td width="36%" valign="bottom"><p>&nbsp; </p></td>
    <td width="4%" valign="bottom"><p>&nbsp; </p></td>
    <td width="34%" valign="bottom"><p>Senior Vice President &ndash; Controller </p></td>
    <td width="4%" valign="bottom"><p>&nbsp; </p></td>
    <td colspan="5" valign="bottom"><p>February 25, 2010</p></td>
    <td width="7%"></td>
  </tr>
  <tr>
    <td><p> <u>/s/Loretta V. Cangialosi </u></p></td>
    <td><p>&nbsp; </p></td>
    <td><p>(Principal Accounting Officer) </p></td>
    <td width="4%"><p>&nbsp; </p></td>
    <td width="6%"><p>&nbsp; </p></td>
    <td width="1%"><p>&nbsp; </p></td>
    <td colspan="3"><p>&nbsp; </p></td>
    <td width="7%"></td>
  </tr>
  <tr>
    <td width="36%" valign="bottom"><p>(Loretta V. Cangialosi)</p></td>
    <td width="4%" valign="bottom"><p>&nbsp; </p></td>
    <td width="34%" valign="bottom"><p>&nbsp;</p></td>
    <td width="4%" valign="bottom"><p>&nbsp; </p></td>
    <td width="6%" valign="bottom"><p>&nbsp; </p></td>
    <td width="1%" valign="bottom"><p>&nbsp; </p></td>
    <td colspan="3" valign="bottom"><p>&nbsp; </p></td>
    <td width="7%"></td>
  </tr>
  <tr>
    <td width="36%" valign="bottom"></td>
    <td width="4%" valign="bottom"><p>&nbsp; </p></td>
    <td width="34%" valign="bottom"><p>&nbsp; </p></td>
    <td width="4%" valign="bottom"><p>&nbsp; </p></td>
    <td colspan="5" valign="bottom"><p align="right">&nbsp; </p></td>
    <td width="7%"></td>
  </tr>
  <tr>
    <td width="36%" valign="bottom"></td>
    <td width="4%" valign="bottom"><p>&nbsp; </p></td>
    <td width="34%" valign="bottom"><p>Director</p></td>
    <td width="4%" valign="bottom"><p>&nbsp; </p></td>
    <td colspan="5" valign="bottom"><p>February 25, 2010</p></td>
    <td width="7%"></td>
  </tr>
  <tr>
    <td width="36%" valign="bottom"><p> <u>/s/Dennis A. Ausiello </u></p></td>
    <td width="4%" valign="bottom"><p>&nbsp; </p></td>
    <td width="34%" valign="bottom"><p>&nbsp; </p></td>
    <td width="4%" valign="bottom"><p>&nbsp; </p></td>
    <td colspan="5" valign="bottom"><p align="right">&nbsp; </p></td>
    <td width="7%"></td>
  </tr>
  <tr>
    <td><p>(Dennis A. Ausiello)</p></td>
    <td><p>&nbsp; </p></td>
    <td><p>&nbsp; </p></td>
    <td width="4%"><p>&nbsp; </p></td>
    <td width="6%"><p>&nbsp; </p></td>
    <td width="1%"><p>&nbsp; </p></td>
    <td colspan="3"><p>&nbsp; </p></td>
    <td width="7%"></td>
  </tr>
  <tr>
    <td width="36%" valign="bottom"></td>
    <td width="4%" valign="bottom"><p>&nbsp; </p></td>
    <td width="34%" valign="bottom"><p>&nbsp; </p></td>
    <td width="4%" valign="bottom"><p>&nbsp; </p></td>
    <td colspan="5" valign="bottom"><p align="right">&nbsp; </p></td>
    <td width="7%"></td>
  </tr>
  <tr>
    <td width="36%" valign="bottom"><p>&nbsp; </p></td>
    <td width="4%" valign="bottom"><p>&nbsp; </p></td>
    <td width="34%" valign="bottom"><p>&nbsp;Director</p></td>
    <td width="4%" valign="bottom"><p>&nbsp; </p></td>
    <td colspan="6" valign="bottom"><p>February 25, 2010</p></td>
  </tr>
  <tr>
    <td><p> <u>/s/Michael S. Brown </u></p></td>
    <td><p>&nbsp; </p></td>
    <td><p>&nbsp; </p></td>
    <td width="4%"><p>&nbsp; </p></td>
    <td colspan="3"><p>&nbsp; </p></td>
    <td width="6%"><p>&nbsp; </p></td>
    <td colspan="2"><p>&nbsp; </p></td>
  </tr>
  <tr>
    <td width="36%" valign="bottom"><p>(Michael S. Brown) </p></td>
    <td width="4%" valign="bottom"><p>&nbsp; </p></td>
    <td width="34%" valign="bottom"><p>&nbsp; </p></td>
    <td width="4%" valign="bottom"><p>&nbsp; </p></td>
    <td colspan="5" valign="bottom"><p align="right">&nbsp; </p></td>
    <td width="7%"></td>
  </tr>
  <tr>
    <td colspan="9"><p>&nbsp; </p></td>
    <td width="7%"></td>
  </tr>
  <tr>
    <td width="36%" valign="bottom"><p>&nbsp; </p></td>
    <td width="4%" valign="bottom"><p>&nbsp; </p></td>
    <td width="34%" valign="bottom"><p>Director </p></td>
    <td width="4%" valign="bottom"><p>&nbsp; </p></td>
    <td colspan="5" valign="bottom"><p>February 25, 2010</p></td>
    <td width="7%"></td>
  </tr>
  <tr>
    <td><p> <u>/s/M. Anthony Burns </u></p></td>
    <td><p>&nbsp; </p></td>
    <td><p>&nbsp; </p></td>
    <td width="4%"><p>&nbsp; </p></td>
    <td width="6%"><p>&nbsp; </p></td>
    <td width="1%"><p>&nbsp; </p></td>
    <td colspan="3"><p>&nbsp; </p></td>
    <td width="7%"></td>
  </tr>
  <tr>
    <td width="36%" valign="bottom"><p>(M. Anthony Burns) </p></td>
    <td width="4%" valign="bottom"><p>&nbsp; </p></td>
    <td width="34%" valign="bottom"><p>&nbsp; </p></td>
    <td width="4%" valign="bottom"><p>&nbsp; </p></td>
    <td width="6%" valign="bottom"><p>&nbsp; </p></td>
    <td width="1%" valign="bottom"><p>&nbsp; </p></td>
    <td colspan="3" valign="bottom"><p>&nbsp; </p></td>
    <td width="7%"></td>
  </tr>
</table>
<p align="center">&nbsp;</p>
<table width="80%" cellpadding="0" cellspacing="0">
  <tr>
    <td width="38%" valign="bottom"><br>
        <p><a name="page_25"></a>&nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp;<strong>SIGNATURE</strong></p></td>
    <td width="8%" valign="bottom"><p>&nbsp;</p></td>
    <td width="22%" valign="bottom"><p align="center"><strong>TITLE</strong></p></td>
    <td width="10%" valign="bottom"><p>&nbsp;</p></td>
    <td colspan="3" valign="bottom"><p align="center"><strong>DATE</strong></p></td>
  </tr>
  <tr>
    <td width="38%" valign="bottom"><p>&nbsp;</p></td>
    <td width="8%" valign="bottom"><p>&nbsp;</p></td>
    <td width="22%" valign="bottom"><p>&nbsp;</p></td>
    <td width="10%" valign="bottom"><p>&nbsp;</p></td>
    <td width="4%" valign="bottom"><p>&nbsp; </p></td>
    <td width="5%" valign="bottom"><p>&nbsp;</p></td>
    <td width="13%" valign="bottom"><p>&nbsp;</p></td>
  </tr>
  <tr>
    <td width="38%" valign="bottom"><p>&nbsp; </p></td>
    <td width="8%" valign="bottom"><p>&nbsp;</p></td>
    <td width="22%" valign="bottom"><p>Director </p></td>
    <td width="10%" valign="bottom"><p>&nbsp;</p></td>
    <td colspan="3" valign="bottom"><p>February 25, 2010</p></td>
  </tr>
  <tr>
    <td><p> <u>/s/Robert N. Burt </u></p></td>
    <td><p>&nbsp; </p></td>
    <td><p>&nbsp;</p></td>
    <td width="10%"><p>&nbsp; </p></td>
    <td width="4%"><p>&nbsp; </p></td>
    <td width="5%"><p>&nbsp; </p></td>
    <td width="13%"><p>&nbsp; </p></td>
  </tr>
  <tr>
    <td width="38%" valign="bottom"><p>(Robert N. Burt) </p></td>
    <td width="8%" valign="bottom"><p>&nbsp;</p></td>
    <td width="22%" valign="bottom"><p>&nbsp;</p></td>
    <td width="10%" valign="bottom"><p>&nbsp;</p></td>
    <td width="4%" valign="bottom"><p>&nbsp; </p></td>
    <td width="5%" valign="bottom"><p>&nbsp;</p></td>
    <td width="13%" valign="bottom"><p>&nbsp;</p></td>
  </tr>
  <tr>
    <td colspan="7"><p>&nbsp;</p></td>
  </tr>
  <tr>
    <td width="38%" valign="bottom"><p>&nbsp; </p></td>
    <td width="8%" valign="bottom"><p>&nbsp;</p></td>
    <td width="22%" valign="bottom"><p>&nbsp;Director</p></td>
    <td width="10%" valign="bottom"><p>&nbsp;</p></td>
    <td colspan="3" valign="bottom"><p>February 25, 2010</p></td>
  </tr>
  <tr>
    <td><p> <u>/s/ W. Don Cornwell </u></p></td>
    <td><p>&nbsp; </p></td>
    <td><p>&nbsp; </p></td>
    <td width="10%"><p>&nbsp; </p></td>
    <td width="4%"><p>&nbsp; </p></td>
    <td width="5%"><p>&nbsp; </p></td>
    <td width="13%"><p>&nbsp; </p></td>
  </tr>
  <tr>
    <td width="38%" valign="bottom"><p>(W. Don Cornwell) </p></td>
    <td width="8%" valign="bottom"><p>&nbsp;</p></td>
    <td width="22%" valign="bottom"><p>&nbsp;</p></td>
    <td width="10%" valign="bottom"><p>&nbsp;</p></td>
    <td width="4%" valign="bottom"><p>&nbsp; </p></td>
    <td width="5%" valign="bottom"><p>&nbsp;</p></td>
    <td width="13%" valign="bottom"><p>&nbsp;</p></td>
  </tr>
  <tr>
    <td colspan="7"><p>&nbsp;</p></td>
  </tr>
  <tr>
    <td width="38%" valign="bottom"><p>&nbsp; </p></td>
    <td width="8%" valign="bottom"><p>&nbsp;</p></td>
    <td width="22%" valign="bottom"><p>Director </p></td>
    <td width="10%" valign="bottom"><p>&nbsp;</p></td>
    <td colspan="3" valign="bottom"><p>February 25, 2010</p></td>
  </tr>
  <tr>
    <td><p> <u>/s/William H. Gray III </u></p></td>
    <td><p>&nbsp; </p></td>
    <td><p>&nbsp;</p></td>
    <td width="10%"><p>&nbsp; </p></td>
    <td width="4%"><p>&nbsp; </p></td>
    <td width="5%"><p>&nbsp; </p></td>
    <td width="13%"><p>&nbsp; </p></td>
  </tr>
  <tr>
    <td width="38%" valign="bottom"><p>(William H. Gray III) </p></td>
    <td width="8%" valign="bottom"><p>&nbsp;</p></td>
    <td width="22%" valign="bottom"><p>&nbsp;</p></td>
    <td width="10%" valign="bottom"><p>&nbsp;</p></td>
    <td width="4%" valign="bottom"><p>&nbsp; </p></td>
    <td width="5%" valign="bottom"><p>&nbsp;</p></td>
    <td width="13%" valign="bottom"><p>&nbsp;</p></td>
  </tr>
  <tr>
    <td colspan="7"><p>&nbsp;</p></td>
  </tr>
  <tr>
    <td width="38%" valign="bottom"><p>&nbsp; </p></td>
    <td width="8%" valign="bottom"><p>&nbsp;</p></td>
    <td width="22%" valign="bottom"><p>Director </p></td>
    <td width="10%" valign="bottom"><p>&nbsp;</p></td>
    <td colspan="3" valign="top"><p>February 25, 2010</p></td>
  </tr>
  <tr>
    <td><p> <u>/s/Constance J. Horner </u></p></td>
    <td><p>&nbsp; </p></td>
    <td><p>&nbsp; </p></td>
    <td width="10%"><p>&nbsp; </p></td>
    <td width="4%"><p>&nbsp; </p></td>
    <td width="5%"><p>&nbsp; </p></td>
    <td width="13%"><p>&nbsp; </p></td>
  </tr>
  <tr>
    <td width="38%" valign="bottom"><p>(Constance J. Horner) </p></td>
    <td width="8%" valign="bottom"><p>&nbsp;</p></td>
    <td width="22%" valign="bottom"><p>&nbsp;</p></td>
    <td width="10%" valign="bottom"><p>&nbsp;</p></td>
    <td width="4%" valign="bottom"><p align="right">&nbsp; </p></td>
    <td width="5%" valign="bottom"><p>&nbsp;</p></td>
    <td width="13%" valign="bottom"><p>&nbsp;</p></td>
  </tr>
  <tr>
    <td colspan="7"><p>&nbsp;</p></td>
  </tr>
  <tr>
    <td width="38%" valign="bottom"><p>&nbsp; </p></td>
    <td width="8%" valign="bottom"><p>&nbsp;</p></td>
    <td width="22%" valign="bottom"><p>Director </p></td>
    <td width="10%" valign="bottom"><p>&nbsp;</p></td>
    <td colspan="3" valign="bottom"><p>February 25, 2010</p></td>
  </tr>
  <tr>
    <td><p> <u>/s/James M. Kilts </u></p></td>
    <td><p>&nbsp; </p></td>
    <td><p>&nbsp; </p></td>
    <td width="10%"><p>&nbsp; </p></td>
    <td width="4%"><p>&nbsp; </p></td>
    <td width="5%"><p>&nbsp; </p></td>
    <td width="13%"><p>&nbsp; </p></td>
  </tr>
  <tr>
    <td width="38%" valign="bottom"><p>(James M. Kilts) </p></td>
    <td width="8%" valign="bottom"><p>&nbsp;</p></td>
    <td width="22%" valign="bottom"><p>&nbsp;</p></td>
    <td width="10%" valign="bottom"><p>&nbsp;</p></td>
    <td width="4%" valign="bottom"><p>&nbsp; </p></td>
    <td width="5%" valign="bottom"><p>&nbsp;</p></td>
    <td width="13%" valign="bottom"><p>&nbsp;</p></td>
  </tr>
  <tr>
    <td valign="bottom"><p>&nbsp;</p></td>
    <td valign="bottom"><p>&nbsp;</p></td>
    <td valign="bottom"><p>&nbsp;</p></td>
    <td width="10%" valign="bottom"><p>&nbsp;</p></td>
    <td width="4%" valign="bottom"><p>&nbsp; </p></td>
    <td width="5%" valign="bottom"><p>&nbsp;</p></td>
    <td width="13%" valign="bottom"><p>&nbsp;</p></td>
  </tr>
  <tr>
    <td valign="bottom"><p>&nbsp; </p></td>
    <td valign="bottom"><p>&nbsp;</p></td>
    <td valign="bottom"><p>Director </p></td>
    <td width="10%" valign="bottom"><p>&nbsp;</p></td>
    <td colspan="3" valign="bottom"><p>February 25, 2010</p></td>
  </tr>
  <tr>
    <td valign="bottom"><p> <u>/s/George A. Lorch </u></p></td>
    <td valign="bottom"><p>&nbsp;</p></td>
    <td valign="bottom"><p>&nbsp;</p></td>
    <td width="10%" valign="bottom"><p>&nbsp;</p></td>
    <td width="4%" valign="bottom"><p>&nbsp; </p></td>
    <td width="5%" valign="bottom"><p>&nbsp;</p></td>
    <td width="13%" valign="bottom"><p>&nbsp;</p></td>
  </tr>
  <tr>
    <td valign="bottom"><p>(George A. Lorch) </p></td>
    <td valign="bottom"><p>&nbsp;</p></td>
    <td valign="bottom"><p>&nbsp;</p></td>
    <td width="10%" valign="bottom"><p>&nbsp;</p></td>
    <td width="4%" valign="bottom"><p>&nbsp; </p></td>
    <td width="5%" valign="bottom"><p>&nbsp;</p></td>
    <td width="13%" valign="bottom"><p>&nbsp;</p></td>
  </tr>
  <tr>
    <td valign="bottom"><p>&nbsp;</p></td>
    <td valign="bottom"><p>&nbsp;</p></td>
    <td valign="bottom"><p>&nbsp;</p></td>
    <td width="10%" valign="bottom"><p>&nbsp;</p></td>
    <td width="4%" valign="bottom"><p>&nbsp; </p></td>
    <td width="5%" valign="bottom"><p>&nbsp;</p></td>
    <td width="13%" valign="bottom"><p>&nbsp;</p></td>
  </tr>
  <tr>
    <td valign="bottom"><p>&nbsp; </p></td>
    <td valign="bottom"><p>&nbsp;</p></td>
    <td valign="bottom"><p>Director </p></td>
    <td width="10%" valign="bottom"><p>&nbsp;</p></td>
    <td colspan="3" valign="bottom"><p>February 25, 2010</p></td>
  </tr>
  <tr>
    <td valign="bottom"><p> <u>/s/Dana G. Mead </u></p></td>
    <td valign="bottom"><p>&nbsp;</p></td>
    <td valign="bottom"><p>&nbsp;</p></td>
    <td width="10%" valign="bottom"><p>&nbsp;</p></td>
    <td width="4%" valign="bottom"><p>&nbsp; </p></td>
    <td width="5%" valign="bottom"><p>&nbsp;</p></td>
    <td width="13%" valign="bottom"><p>&nbsp;</p></td>
  </tr>
  <tr>
    <td valign="bottom"><p>(Dana G. Mead) </p></td>
    <td valign="bottom"><p>&nbsp;</p></td>
    <td valign="bottom"><p>&nbsp;</p></td>
    <td width="10%" valign="bottom"><p>&nbsp;</p></td>
    <td width="4%" valign="bottom"><p>&nbsp; </p></td>
    <td width="5%" valign="bottom"><p>&nbsp;</p></td>
    <td width="13%" valign="bottom"><p>&nbsp;</p></td>
  </tr>
  <tr>
    <td valign="bottom"><p>&nbsp;</p></td>
    <td valign="bottom"><p>&nbsp;</p></td>
    <td valign="bottom"><p>&nbsp;</p></td>
    <td width="10%" valign="bottom"><p>&nbsp;</p></td>
    <td width="4%" valign="bottom"><p>&nbsp; </p></td>
    <td width="5%" valign="bottom"><p>&nbsp;</p></td>
    <td width="13%" valign="bottom"><p>&nbsp;</p></td>
  </tr>
  <tr>
    <td valign="bottom"><p>&nbsp; </p></td>
    <td valign="bottom"><p>&nbsp;</p></td>
    <td valign="bottom"><p>Director </p></td>
    <td width="10%" valign="bottom"><p>&nbsp;</p></td>
    <td colspan="3" valign="bottom"><p>February 25, 2010</p></td>
  </tr>
  <tr>
    <td valign="bottom"><p> <u>/s/Suzanne Nora Johnson </u></p></td>
    <td valign="bottom"><p>&nbsp;</p></td>
    <td valign="bottom"><p>&nbsp;</p></td>
    <td width="10%" valign="bottom"><p>&nbsp;</p></td>
    <td width="4%" valign="bottom"><p>&nbsp; </p></td>
    <td width="5%" valign="bottom"><p>&nbsp;</p></td>
    <td width="13%" valign="bottom"><p>&nbsp;</p></td>
  </tr>
  <tr>
    <td valign="bottom"><p>(Suzanne Nora Johnson) </p></td>
    <td valign="bottom"><p>&nbsp;</p></td>
    <td valign="bottom"><p>&nbsp;</p></td>
    <td width="10%" valign="bottom"><p>&nbsp;</p></td>
    <td width="4%" valign="bottom"><p>&nbsp; </p></td>
    <td width="5%" valign="bottom"><p>&nbsp;</p></td>
    <td width="13%" valign="bottom"><p>&nbsp;</p></td>
  </tr>
  <tr>
    <td valign="bottom"><p>&nbsp; </p></td>
    <td valign="bottom"><p>&nbsp;</p></td>
    <td valign="bottom"><p>&nbsp; </p></td>
    <td width="10%" valign="bottom"><p>&nbsp;</p></td>
    <td colspan="3" valign="bottom"><p align="right">&nbsp; </p></td>
  </tr>
  <tr>
    <td valign="bottom"><p>&nbsp; </p></td>
    <td valign="bottom"><p>&nbsp;</p></td>
    <td valign="bottom"><p>Director </p></td>
    <td width="10%" valign="bottom"><p>&nbsp;</p></td>
    <td colspan="3" valign="bottom"><p>February 25, 2010</p></td>
  </tr>
  <tr>
    <td valign="bottom"><p> <u>/s/Stephen W. Sanger </u></p></td>
    <td valign="bottom"><p>&nbsp; </p></td>
    <td valign="bottom"><p>&nbsp; </p></td>
    <td width="10%" valign="bottom"><p>&nbsp; </p></td>
    <td width="4%" valign="bottom"><p>&nbsp; </p></td>
    <td width="5%" valign="bottom"><p>&nbsp; </p></td>
    <td width="13%" valign="bottom"><p>&nbsp; </p></td>
  </tr>
  <tr>
    <td valign="bottom"><p>(Stephen W. Sanger)</p></td>
    <td valign="bottom"><p>&nbsp; </p></td>
    <td valign="bottom"><p>&nbsp; </p></td>
    <td width="10%" valign="bottom"><p>&nbsp; </p></td>
    <td width="4%" valign="bottom"><p>&nbsp; </p></td>
    <td width="5%" valign="bottom"><p>&nbsp; </p></td>
    <td width="13%" valign="bottom"><p>&nbsp; </p></td>
  </tr>
  <tr>
    <td valign="bottom"><p>&nbsp; </p></td>
    <td valign="bottom"><p>&nbsp; </p></td>
    <td valign="bottom"><p>&nbsp; </p></td>
    <td width="10%" valign="bottom"><p>&nbsp; </p></td>
    <td colspan="3" valign="bottom"><p align="right">&nbsp; </p></td>
  </tr>
  <tr>
    <td valign="bottom"><p>&nbsp; </p></td>
    <td valign="bottom"><p>&nbsp;</p></td>
    <td valign="bottom"><p>Director </p></td>
    <td width="10%" valign="bottom"><p>&nbsp;</p></td>
    <td colspan="3" valign="bottom"><p>February 25, 2010</p></td>
  </tr>
  <tr>
    <td valign="bottom"><p> <u>/s/William C. Steere, Jr. </u></p></td>
    <td valign="bottom"><p>&nbsp;</p></td>
    <td valign="bottom"><p>&nbsp;</p></td>
    <td width="10%" valign="bottom"><p>&nbsp;</p></td>
    <td width="4%" valign="bottom"><p>&nbsp; </p></td>
    <td width="5%" valign="bottom"><p>&nbsp;</p></td>
    <td width="13%" valign="bottom"><p>&nbsp;</p></td>
  </tr>
  <tr>
    <td valign="bottom"><p>(William C. Steere, Jr.) </p></td>
    <td valign="bottom"><p>&nbsp;</p></td>
    <td valign="bottom"><p>&nbsp;</p></td>
    <td width="10%" valign="bottom"><p>&nbsp;</p></td>
    <td width="4%" valign="bottom"><p>&nbsp; </p></td>
    <td width="5%" valign="bottom"><p>&nbsp;</p></td>
    <td width="13%" valign="bottom"><p>&nbsp;</p></td>
  </tr>
</table>
<p>________________________________________________________________________________</p>
<p><strong>EXHIBIT INDEX </strong><strong>&nbsp;</strong></p>
<table cellspacing="0" cellpadding="0">
  <tr>
    <td width="130"><p><strong> <u>Exhibit Number</u></strong></p></td>
    <td width="587"><p><strong> <u>Exhibit </u></strong></p></td>
  </tr>
  <tr>
    <td width="130"><p> 5.1 </p></td>
    <td width="587"><p> Opinion of Matthew Lepore, Esq., Vice President, Chief Counsel &ndash; Corporate Governance, and Assistant General Counsel of the Company* </p></td>
  </tr>
  <tr>
    <td width="130"><p> 23(i)&nbsp;&nbsp; </p></td>
    <td width="587"><p> Consent of Matthew Lepore, Esq., Vice President, Chief Counsel &ndash; Corporate Governance, and Assistant General Counsel of the Company (included in Exhibit 5.1)* </p></td>
  </tr>
  <tr>
    <td width="130"><p> 23(ii)&nbsp; </p></td>
    <td width="587"><p> Consent of KPMG LLP, Independent Registered Public Accounting Firm of the Company* </p></td>
  </tr>
  <tr>
    <td width="130"><p> 24&nbsp; &nbsp;&nbsp;&nbsp; </p></td>
    <td width="587"><p> Power of Attorney (included on signature page(s) to this Registration Statement)* </p></td>
  </tr>
</table>
<p><strong> &nbsp;</strong>________________ </p>
<p> * Filed herewith <strong>&nbsp;</strong></p>
<p><br>
</p>
<p align="right">&nbsp;</p>
</body>
</html>
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{"company-data": {"conformed-name": "PFIZER INC", "cik": "0000078003", "assigned-sic": "2834", "irs-number": "135315170", "state-of-incorporation": "DE", "fiscal-year-end": "1231"}, "filing-values": {"form-type": "S-8", "act": "33", "file-number": "333-165121", "film-number": "10644328"}, "business-address": {"street1": "235 E 42ND ST", "city": "NEW YORK", "state": "NY", "zip": "10017", "phone": "2125732323"}, "mail-address": {"street1": "235 E 42ND ST", "city": "NEW YORK", "state": "NY", "zip": "10017"}, "former-company": {"former-conformed-name": "PFIZER CHARLES & CO INC", "date-changed": "19710908"}}
As filed with the Securities and Exchange Commission on March 1, 2010
Registration Statement No. 333- ______
_____________________________________________________________________________________________
UNITED STATES
SECURITIES AND EXCHANGE COMMISSION
Washington
, D.C. 20549
FORM S-8
REGISTRATION STATEMENT
Under
THE SECURITIES ACT OF 1933
PFIZER INC.
(Exact name of Registrant as specified in its charter)
DELAWARE
13-5315170
(State of Incorporation)
(I.R.S. Employer Identification No.)
235 EAST 42ND STREET
NEW YORK, NEW YORK 10017-5755
(Address of Principal Executive Offices)
Pfizer Inc.
2004 Stock Plan, As Amended and Restated
(Full Title of the Plan)
Matthew Lepore, Esq.
Pfizer Inc.
235 East 42nd Street
New York, New York 10017-5755
(Name and Address of Agent for Service)
(212) 733-2323
(Telephone Number, including area code, of Agent for Service)
Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, a non‑accelerated filer, or a smaller reporting company. See the definitions of "large accelerated filer," "accelerated filer" and "smaller reporting company" in Rule 12b‑2 of the Exchange Act. (Check one):
Large accelerated filer |X|
Accelerated filer
Non‑accelerated filer
(Do not check if a smaller reporting company)
Smaller reporting company
CALCULATION OF REGISTRATION FEE
Title of Securities to be Registered
Amount to be Registered
Proposed Maximum Offering Price Per Share
(1)
Proposed Maximum Aggregate Offering Price
(1)
Amount of Registration Fee
(1)
Common Stock, $.05 par value
425,000,000 shares
$17.81
$7,569,250,000
$539,687.52
(1)  Calculated in accordance  with Rule 457(c) and Rule 457(h)(1) under the Securities Act of 1933, as  amended (the "Securities Act"), solely for the purpose of calculating the  registration fee. The offering price per share is based on the average of the  high and the low prices per share of Pfizer Inc. Common Stock on February 24,  2010, which was $17.81, as reported on the New York Stock Exchange.  In addition, pursuant to Rule 416(a) under  the Securities Act, this Registration Statement covers any additional shares of  such Common Stock that become issuable pursuant to terms of the Pfizer Inc.  2004 Stock Plan, as Amended and Restated, providing for an increase in the  amount of shares of such Common Stock to be issued thereunder as a result of a  stock dividend, stock split, recapitalization or any other similar transaction.
INTRODUCTION
This Registration Statement  on Form S-8 is filed with the Securities and Exchange Commission (the  "Commission") by Pfizer Inc., a Delaware corporation (the "Company"), relating  to the registration of 425,000,000 shares (the "Shares") of Company's Common  Stock, par value $.05 per share (the "Common Stock"), to be offered under the  Pfizer Inc. 2004 Stock Plan (the "Plan"), as amended and restated. The Shares  are being registered in addition to the Common Stock previously registered for  issuance on the Company's Registration Statement on Form S−8 concerning the  Plan filed with the Commission on April 26, 2004 (Reg. No. 333−114852) (the  "2004 Registration Statement").  Pursuant  to General Instruction E to Form S−8, the contents of the 2004 Registration  Statement are incorporated by reference herein, except to the extent  supplemented, amended or superseded by the information set forth herein.
PART II.
INFORMATION REQUIRED IN THE REGISTRATION STATEMENT
ITEM 3. INCORPORATION OF  DOCUMENTS BY REFERENCE
The following documents filed with  the Commission are hereby incorporated by reference in this Registration  Statement:
the Company's Annual  Report on Form 10-K for the year ended December 31, 2009;
all other reports  filed under Sections 13(a) or 15(d) of the Securities Exchange Act of 1934, as  amended (the "Exchange Act"), since the end of the fiscal year covered by the  financial statements included in the Company's most recent Annual Report on  Form 10-K; and
the description of the  Common Stock contained in the Company's Registration Statement filed under  Section 12 of the Exchange Act on March 1, 2004, including all amendments and  reports updating such description.
All documents filed by the Company under Section  13(a), 13(c), 14, and 15(d) of the Exchange Act after the date of this  Registration Statement and prior to the filing of a post-effective amendment to  this Registration Statement indicating that all securities offered have been  sold or that deregisters the distribution of all securities then remaining  unsold, will be deemed to be incorporated by reference into this Registration  Statement and will be a part of this Registration Statement from the date that  document is filed.  Any statement contained in a document incorporated or  deemed to be incorporated by reference herein shall be deemed to be modified or  superseded for the purposes of this Registration Statement to the extent that a  statement contained in this Registration Statement or in any other subsequently  filed document that also is or is deemed to be incorporated by reference herein  modifies or supersedes such statement.  Any statement so modified or  superseded shall not be deemed, except as so modified or superseded, to  constitute a part of this Registration Statement.  The Company's Exchange  Act file number with the Commission is 001-03619.
ITEM 5. INTERESTS OF NAMED EXPERTS AND COUNSEL
The validity of the  securities has been passed upon by Matthew Lepore, Esq., Vice President, Chief Counsel  – Corporate Governance, and Assistant General Counsel of the Company.  Mr. Lepore beneficially owns Common Stock and  options to purchase Common Stock granted under the Plan.
ITEM 8. EXHIBITS
Exhibit Number
Exhibit
5.1
Opinion of Matthew Lepore, Esq., Vice President, Chief Counsel – Corporate Governance, and Assistant General Counsel of the Company*
23(i)
Consent of Matthew Lepore, Esq., Vice President, Chief Counsel – Corporate Governance, and Assistant General Counsel of the Company (included in Exhibit 5.1)*
23(ii)
Consent of KPMG LLP, Independent Registered Public Accounting Firm of the Company*
24
Power of Attorney (included on signature page(s) to this Registration Statement)*
________________
* Filed herewith
_______________________________________________________________________________________________________
SIGNATURES
Pursuant to the requirements of the Securities  Act of 1933, the Registrant certifies that it has reasonable grounds to believe  that it meets all of the requirements for filing on Form S-8 and has duly  caused this Registration Statement to be signed on its behalf by the  undersigned, thereunto duly authorized, in the City of New York, State of New  York, on the 25th day of February, 2010.
PFIZER INC.
By
/s/Jeffrey B. Kindler
Jeffrey B. Kindler
Chairman of the Board, Chief
Executive Officer and Director
(Principal Executive Officer)
Each person whose signature appears below hereby  constitutes and appoints Amy W. Schulman and Matthew Lepore and each of them  his or her true and lawful attorneys-in-fact and agents, with full power of  substitution and resubstitution, for him or her and in his or her name, place  and stead, in any and all capacities, to sign any and all amendments (including  post-effective amendments) and supplements to this Registration Statement, and  to file the same, with all exhibits thereto, and other documents in connection  therewith, with the Securities and Exchange Commission, and hereby grants to  such attorneys-in-fact and agents full power and authority to do and perform  each and every act and thing requisite and necessary to be done, as fully to  all intents and purposes as he or she might or could do in person, hereby  ratifying and confirming all that said attorneys-in-fact and agents, or either  of them, or their or his or her substitute or substitutes, may lawfully do or  cause to be done by virtue hereof.
Pursuant to the requirements of the Securities Act of 1933, this Registration Statement has been signed below by the following persons in the capacities and on the dates indicated.
SIGNATURE
TITLE
DATE
Chairman of the Board, Chief
Executive Officer and Director
February 25, 2010
/s/Jeffrey B. Kindler
(Principal Executive Officer)
(Jeffrey B. Kindler)
Senior Vice President and
Chief Financial Officer
(Principal Financial Officer)
February 25, 2010
/s/Frank A. D'Amelio
(Frank A. D'Amelio)
Senior Vice President – Controller
February 25, 2010
/s/Loretta V. Cangialosi
(Principal Accounting Officer)
(Loretta V. Cangialosi)
Director
February 25, 2010
/s/Dennis A. Ausiello
(Dennis A. Ausiello)
Director
February 25, 2010
/s/Michael S. Brown
(Michael S. Brown)
Director
February 25, 2010
/s/M. Anthony Burns
(M. Anthony Burns)
SIGNATURE
TITLE
DATE
Director
February 25, 2010
/s/Robert N. Burt
(Robert N. Burt)
Director
February 25, 2010
/s/ W. Don Cornwell
(W. Don Cornwell)
Director
February 25, 2010
/s/William H. Gray III
(William H. Gray III)
Director
February 25, 2010
/s/Constance J. Horner
(Constance J. Horner)
Director
February 25, 2010
/s/James M. Kilts
(James M. Kilts)
Director
February 25, 2010
/s/George A. Lorch
(George A. Lorch)
Director
February 25, 2010
/s/Dana G. Mead
(Dana G. Mead)
Director
February 25, 2010
/s/Suzanne Nora Johnson
(Suzanne Nora Johnson)
Director
February 25, 2010
/s/Stephen W. Sanger
(Stephen W. Sanger)
Director
February 25, 2010
/s/William C. Steere, Jr.
(William C. Steere, Jr.)
________________________________________________________________________________
EXHIBIT INDEX
Exhibit Number
Exhibit
5.1
Opinion of Matthew Lepore, Esq., Vice President, Chief Counsel – Corporate Governance, and Assistant General Counsel of the Company*
23(i)
Consent of Matthew Lepore, Esq., Vice President, Chief Counsel – Corporate Governance, and Assistant General Counsel of the Company (included in Exhibit 5.1)*
23(ii)
Consent of KPMG LLP, Independent Registered Public Accounting Firm of the Company*
24
Power of Attorney (included on signature page(s) to this Registration Statement)*
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* Filed herewith