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WWW.EXFILE.COM, INC. -- 14080 -- CLINICAL DATA, INC. -- FORM 8-K
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      <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 0pt" align="right"><font style="DISPLAY: inline; FONT-SIZE: 9pt; FONT-FAMILY: Times New Roman">Registration
        No. 333-_____________</font><br></div>
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      <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 0pt" align="center"><font style="DISPLAY: inline; FONT-SIZE: 9pt; FONT-FAMILY: Times New Roman"><strong>SECURITIES
        AND EXCHANGE COMMISSION</strong></font></div>
      <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 0pt" align="center"><font style="DISPLAY: inline; FONT-SIZE: 9pt; FONT-FAMILY: Times New Roman"><strong>WASHINGTON,
        D.C. 20549</strong></font></div>
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      <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 0pt" align="center"><br></div>
      <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 0pt" align="center"><font style="DISPLAY: inline; FONT-SIZE: 12pt; FONT-FAMILY: Times New Roman"><strong>FORM
        S-8</strong></font></div>
      <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 0pt" align="center"><font style="DISPLAY: inline; FONT-SIZE: 12pt; FONT-FAMILY: Times New Roman"><strong>REGISTRATION
        STATEMENT </strong></font></div>
      <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 0pt" align="center"><font style="DISPLAY: inline; FONT-SIZE: 12pt; FONT-FAMILY: Times New Roman"><strong>UNDER</strong></font></div>
      <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 0pt" align="center"><font style="DISPLAY: inline; FONT-SIZE: 12pt; FONT-FAMILY: Times New Roman"><strong>THE
        SECURITIES ACT OF 1933</strong></font></div>
      <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 0pt" align="justify">&#160;</div>
      <div>&#160;

        <div>
          <hr style="COLOR: black" align="center" noshade size="2" width="20%">
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      </div>
      <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 0pt" align="justify">&#160;</div>
      <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 0pt" align="center"><font style="DISPLAY: inline; FONT-SIZE: 18pt; FONT-FAMILY: Times New Roman"><strong>CLINICAL
        DATA, INC.</strong></font></div>
      <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 0pt" align="center"><font style="DISPLAY: inline; FONT-SIZE: 9pt; FONT-FAMILY: Times New Roman">(Exact
        name of Registrant as specified in its charter)</font></div>
      <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 0pt" align="left"><br></div>
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              <td valign="top" width="35%" style="border-bottom: black thin solid;">
                <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 0pt" align="center"><font style="DISPLAY: inline; FONT-SIZE: 9pt; FONT-FAMILY: Times New Roman"><strong>Delaware</strong></font></div>
              </td>
              <td valign="top" width="10%">&#160;</td>
              <td valign="top" width="35%" style="border-bottom: black thin solid;">
                <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 0pt" align="center"><font style="DISPLAY: inline; FONT-SIZE: 9pt; FONT-FAMILY: Times New Roman"><strong>04-2573920</strong></font></div>
              </td>
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                <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 0pt" align="center"><font style="DISPLAY: inline; FONT-SIZE: 9pt; FONT-FAMILY: Times New Roman">(State
                  or Other Jurisdiction of Incorporation or Organization)</font></div>
              </td>
              <td valign="top" width="10%">&#160;</td>
              <td valign="top" width="35%">
                <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 0pt" align="center"><font style="DISPLAY: inline; FONT-SIZE: 9pt; FONT-FAMILY: Times New Roman">(I.R.S.
                  Employer Identification Number)</font></div>
              </td>
              <td width="10%">&#160;</td>
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        </table>
      </div>
      <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 0pt" align="left"><br></div>
      <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 0pt" align="center"><font style="DISPLAY: inline; FONT-SIZE: 9pt; FONT-FAMILY: Times New Roman"><strong>One
        Gateway Center, Suite 411</strong></font></div>
      <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 0pt" align="center"><font style="DISPLAY: inline; FONT-SIZE: 9pt; FONT-FAMILY: Times New Roman"><strong>Newton,
        MA 02458</strong></font></div>
      <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 0pt" align="center"><font style="DISPLAY: inline; FONT-SIZE: 9pt; FONT-FAMILY: Times New Roman"><strong>(617)
        527-9933 </strong></font>
        <div>
          <hr style="COLOR: black" align="center" noshade size="2" width="40%">
        </div>
      </div>
      <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 0pt" align="center"><font style="DISPLAY: inline; FONT-SIZE: 9pt; FONT-FAMILY: Times New Roman">(Address
        of Principal Executive Offices, including Zip Code and Telephone
        Number)</font></div>
      <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 0pt" align="left"><br></div>
      <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 0pt" align="center"><font style="DISPLAY: inline; FONT-SIZE: 9pt; FONT-FAMILY: Times New Roman"><strong>Options
        assumed by Clinical Data, Inc. in connection with the merger of a wholly-owned
        </strong></font></div>
      <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 0pt" align="center"><font style="DISPLAY: inline; FONT-SIZE: 9pt; FONT-FAMILY: Times New Roman"><strong>subsidiary
        of Clinical Data with Icoria, Inc., originally granted
        under</strong></font></div>
      <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 0pt" align="center"><font style="DISPLAY: inline; FONT-SIZE: 9pt; FONT-FAMILY: Times New Roman"><strong>Icoria,
        Inc. 2003 Employee, Director and Consultant Stock Plan, as restated,
        and</strong></font></div>
      <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 0pt" align="center"><font style="DISPLAY: inline; FONT-SIZE: 9pt; FONT-FAMILY: Times New Roman"><strong>TissueInformatics.Inc
        2001 Stock Option Plan </strong></font>
        <div>
          <hr style="COLOR: black" align="center" noshade size="2" width="40%">
        </div>
      </div>
      <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 0pt" align="center"><font style="DISPLAY: inline; FONT-SIZE: 9pt; FONT-FAMILY: Times New Roman">(Full
        Title of the Plan)</font></div>
      <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 0pt" align="left"><br></div>
      <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 0pt" align="center"><font style="DISPLAY: inline; FONT-SIZE: 9pt; FONT-FAMILY: Times New Roman"><strong>Israel
        M. Stein, M.D.</strong></font></div>
      <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 0pt" align="center"><font style="DISPLAY: inline; FONT-SIZE: 9pt; FONT-FAMILY: Times New Roman"><strong>President
        and Chief Executive Officer</strong></font></div>
      <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 0pt" align="center"><font style="DISPLAY: inline; FONT-SIZE: 9pt; FONT-FAMILY: Times New Roman"><strong>Clinical
        Data, Inc.</strong></font></div>
      <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 0pt" align="center"><font style="DISPLAY: inline; FONT-SIZE: 9pt; FONT-FAMILY: Times New Roman"><strong>One
        Gateway Center, Suite 411</strong></font></div>
      <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 0pt" align="center"><font style="DISPLAY: inline; FONT-SIZE: 9pt; FONT-FAMILY: Times New Roman"><strong>Newton,
        MA 02458</strong></font></div>
      <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 0pt" align="center"><font style="DISPLAY: inline; FONT-SIZE: 9pt; FONT-FAMILY: Times New Roman"><strong>(617)
        527-9933 </strong></font>
        <div>
          <hr style="COLOR: black" align="center" noshade size="2" width="40%">
        </div>
      </div>
      <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 0pt" align="center"><font style="DISPLAY: inline; FONT-SIZE: 9pt; FONT-FAMILY: Times New Roman">(Name,
        Address, including Zip Code, and Telephone Number, </font></div>
      <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 0pt" align="center"><font style="DISPLAY: inline; FONT-SIZE: 9pt; FONT-FAMILY: Times New Roman">including
        Area Code, </font></div>
      <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 0pt" align="center"><font style="DISPLAY: inline; FONT-SIZE: 9pt; FONT-FAMILY: Times New Roman">of
        Agent
        for Service)</font></div>
      <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 0pt" align="center">&#160;</div>
      <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 0pt" align="center">
        <div>
          <hr style="COLOR: black" align="center" noshade size="2" width="40%">
        </div>
      </div>
      <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 0pt" align="center"><font style="DISPLAY: inline; FONT-SIZE: 9pt; FONT-FAMILY: Times New Roman">(with
        a
        copy to)</font></div>
      <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 0pt" align="center"><font style="DISPLAY: inline; FONT-SIZE: 9pt; FONT-FAMILY: Times New Roman">John
        Hession</font></div>
      <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 0pt" align="center"><font style="DISPLAY: inline; FONT-SIZE: 9pt; FONT-FAMILY: Times New Roman">Marc
        Recht</font></div>
      <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 0pt" align="center"><font style="DISPLAY: inline; FONT-SIZE: 9pt; FONT-FAMILY: Times New Roman">McDermott
        Will &amp; Emery LLP</font></div>
      <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 0pt" align="center"><font style="DISPLAY: inline; FONT-SIZE: 9pt; FONT-FAMILY: Times New Roman">28
        State
        Street</font></div>
      <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 0pt" align="center"><font style="DISPLAY: inline; FONT-SIZE: 9pt; FONT-FAMILY: Times New Roman">Boston,
        MA
        02109</font></div>
      <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 0pt" align="center"><font style="DISPLAY: inline; FONT-SIZE: 9pt; FONT-FAMILY: Times New Roman">(617)
        535-4000</font><br></div>
      <div>&#160;

        <div>
          <hr style="COLOR: black" align="center" noshade size="2" width="20%">
        </div>
      </div>
      <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 0pt" align="center"><br></div>
      <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 0pt" align="center"><font style="DISPLAY: inline; FONT-SIZE: 9pt; FONT-FAMILY: Times New Roman"><strong>CALCULATION
        OF REGISTRATION FEE</strong></font></div>
      <div>
        <table cellpadding="0" cellspacing="0" width="100%">

            <tr>
              <td valign="bottom" width="31%" style="border-bottom: black double;">&#160;</td>
              <td valign="bottom" width="15%" style="border-bottom: black double;">&#160;</td>
              <td valign="bottom" width="15%" style="border-bottom: black double;">&#160;</td>
              <td valign="bottom" width="16%" style="border-bottom: black double;">&#160;</td>
              <td valign="bottom" width="15%" style="border-bottom: black double;">&#160;</td>
            </tr>
            <tr>
              <td valign="bottom" width="31%" style="border-bottom: black double;">
                <div style="DISPLAY: block; MARGIN-LEFT: 9pt; TEXT-INDENT: 0pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 0pt" align="center"><font style="DISPLAY: inline; FONT-SIZE: 9pt; FONT-FAMILY: Times New Roman"><strong>Title
                  of Securities to be Registered</strong></font></div>
              </td>
              <td valign="bottom" width="15%" style="border-bottom: black double;">
                <div style="DISPLAY: block; MARGIN-LEFT: 9pt; TEXT-INDENT: 0pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 0pt" align="center"><font style="DISPLAY: inline; FONT-SIZE: 9pt; FONT-FAMILY: Times New Roman"><strong>Amount
                  to be</strong></font></div>
                <div style="DISPLAY: block; MARGIN-LEFT: 9pt; TEXT-INDENT: 0pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 0pt" align="center"><font style="DISPLAY: inline; FONT-SIZE: 9pt; FONT-FAMILY: Times New Roman"><strong>Registered(1)</strong></font></div>
              </td>
              <td valign="bottom" width="15%" style="border-bottom: black double;">
                <div style="DISPLAY: block; MARGIN-LEFT: 9pt; TEXT-INDENT: 0pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 0pt" align="center"><font style="DISPLAY: inline; FONT-SIZE: 9pt; FONT-FAMILY: Times New Roman"><strong>Proposed
                  Maximum</strong></font></div>
                <div style="DISPLAY: block; MARGIN-LEFT: 9pt; TEXT-INDENT: 0pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 0pt" align="center"><font style="DISPLAY: inline; FONT-SIZE: 9pt; FONT-FAMILY: Times New Roman"><strong>Offering
                  Price</strong></font></div>
                <div style="DISPLAY: block; MARGIN-LEFT: 9pt; TEXT-INDENT: 0pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 0pt" align="center"><font style="DISPLAY: inline; FONT-SIZE: 9pt; FONT-FAMILY: Times New Roman"><strong>Per
                  Share(2)</strong></font></div>
              </td>
              <td valign="bottom" width="16%" style="border-bottom: black double;">
                <div style="DISPLAY: block; MARGIN-LEFT: 9pt; TEXT-INDENT: 0pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 0pt" align="center"><font style="DISPLAY: inline; FONT-SIZE: 9pt; FONT-FAMILY: Times New Roman"><strong>Proposed
                  Maximum</strong></font></div>
                <div style="DISPLAY: block; MARGIN-LEFT: 9pt; TEXT-INDENT: 0pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 0pt" align="center"><font style="DISPLAY: inline; FONT-SIZE: 9pt; FONT-FAMILY: Times New Roman"><strong>Aggregate
                  Offering</strong></font></div>
                <div style="DISPLAY: block; MARGIN-LEFT: 9pt; TEXT-INDENT: 0pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 0pt" align="center"><font style="DISPLAY: inline; FONT-SIZE: 9pt; FONT-FAMILY: Times New Roman"><strong>Price(2)</strong></font></div>
              </td>
              <td valign="bottom" width="15%" style="border-bottom: black double;">
                <div style="DISPLAY: block; MARGIN-LEFT: 9pt; TEXT-INDENT: 0pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 0pt" align="center"><font style="DISPLAY: inline; FONT-SIZE: 9pt; FONT-FAMILY: Times New Roman"><strong>Amount
                  of</strong></font></div>
                <div style="DISPLAY: block; MARGIN-LEFT: 9pt; TEXT-INDENT: 0pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 0pt" align="center"><font style="DISPLAY: inline; FONT-SIZE: 9pt; FONT-FAMILY: Times New Roman"><strong>Registration</strong></font></div>
                <div style="DISPLAY: block; MARGIN-LEFT: 9pt; TEXT-INDENT: 0pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 0pt" align="center"><font style="DISPLAY: inline; FONT-SIZE: 9pt; FONT-FAMILY: Times New Roman"><strong>Fee</strong></font></div>
              </td>
            </tr>
            <tr>
              <td align="left" valign="bottom" width="31%" style="border-bottom: black double;">
                <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 0pt" align="justify"><font style="DISPLAY: inline; FONT-SIZE: 9pt; FONT-FAMILY: Times New Roman">Common
                  Stock, par value $0.01 per share</font></div>
              </td>
              <td valign="bottom" width="15%" style="border-bottom: black double;">
                <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 0pt" align="justify">&#160;</div>
                <div style="DISPLAY: block; MARGIN-LEFT: 9pt; TEXT-INDENT: 0pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 0pt" align="center"><font style="DISPLAY: inline; FONT-SIZE: 9pt; FONT-FAMILY: Times New Roman">40,000
                  shares</font></div>
              </td>
              <td valign="bottom" width="15%" style="border-bottom: black double;">
                <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 0pt" align="justify">&#160;</div>
                <div style="DISPLAY: block; MARGIN-LEFT: 9pt; TEXT-INDENT: 0pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 0pt" align="center"><font style="DISPLAY: inline; FONT-SIZE: 9pt; FONT-FAMILY: Times New Roman">$18.45</font></div>
              </td>
              <td valign="bottom" width="16%" style="border-bottom: black double;">
                <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 0pt" align="justify">&#160;</div>
                <div style="DISPLAY: block; MARGIN-LEFT: 9pt; TEXT-INDENT: 0pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 0pt" align="center"><font style="DISPLAY: inline; FONT-SIZE: 9pt; FONT-FAMILY: Times New Roman">$737,800</font></div>
              </td>
              <td valign="bottom" width="15%" style="border-bottom: black double;">
                <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 0pt" align="justify">&#160;</div>
                <div style="DISPLAY: block; MARGIN-LEFT: 9pt; TEXT-INDENT: 0pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 0pt" align="center"><font style="DISPLAY: inline; FONT-SIZE: 9pt; FONT-FAMILY: Times New Roman">$79</font></div>
              </td>
            </tr>

        </table>
      </div>
      <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 0pt" align="left"><font style="DISPLAY: inline; FONT-SIZE: 9pt; FONT-FAMILY: Times New Roman">________________</font></div>
      <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 0pt" align="left"><br></div>
      <div>
        <table cellpadding="0" cellspacing="0" id="list" width="100%" style="MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt">

            <tr valign="top" style="line-height: 1.25;">
              <td align="right" style="width: 18pt;"><font style="DISPLAY: inline; FONT-SIZE: 9pt; FONT-FAMILY: Times New Roman">(1)&#160;&#160;</font></td>
              <td>
                <div style="MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt" align="justify"><font style="DISPLAY: inline; FONT-SIZE: 9pt; FONT-FAMILY: Times New Roman">Plus,
                  pursuant to Rule 416(a) under the Securities Act, such additional
                  number
                  of shares as may be required in the event of a stock dividend,
                  split-up of
                  shares or other similar change in the Common
                  Stock.</font></div>
              </td>
            </tr>

        </table>
      </div>
      <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 0pt" align="justify">&#160;</div>
      <div>
        <table cellpadding="0" cellspacing="0" id="list" width="100%">

            <tr valign="top" style="line-height: 1.25;">
              <td align="right" style="width: 18pt;"><font style="DISPLAY: inline; FONT-SIZE: 9pt; FONT-FAMILY: Times New Roman">(2)&#160;&#160;</font></td>
              <td>
                <div style="MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt" align="justify"><font style="DISPLAY: inline; FONT-SIZE: 9pt; FONT-FAMILY: Times New Roman">Estimated
                  solely for the purpose of computing the amount of the registration
                  fee
                  under Rules 457(c) and 457(h)(1) based on the average of the high
                  and low
                  price per share of the Registrant&#8217;s Common Stock on the NASDAQ National
                  Market on January 6, 2006. </font></div>
              </td>
            </tr>

        </table>
      </div>
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      <div style="DISPLAY: block; MARGIN-LEFT: 18pt; TEXT-INDENT: -18pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 0pt" align="left"><br></div>
      <div style="MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt" align="center">
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      </div>
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      <div style="MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt" align="center">&#160;</div>
      <div id="PGBRK" style="MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt">
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      <div style="MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt" align="center"><font style="DISPLAY: inline; FONT-SIZE: 9pt; FONT-FAMILY: Times New Roman"><strong>INTRODUCTORY
        STATEMENT</strong></font></div>
      <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 0pt" align="justify">&#160;</div>
      <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 36pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 0pt" align="left"><font style="DISPLAY: inline; FONT-SIZE: 9pt; FONT-FAMILY: Times New Roman">Pursuant
        to an Agreement and Plan of Merger, dated September 19, 2005 (the &#8220;</font><font style="DISPLAY: inline; FONT-SIZE: 9pt; FONT-FAMILY: Times New Roman"><em><u>Merger
        Agreement</u></em></font><font style="DISPLAY: inline; FONT-SIZE: 9pt; FONT-FAMILY: Times New Roman">&#8221;),
        among
        Clinical Data, Inc. (the &#8220;</font><font style="DISPLAY: inline; FONT-SIZE: 9pt; FONT-FAMILY: Times New Roman"><em><u>Registrant</u></em></font><font style="DISPLAY: inline; FONT-SIZE: 9pt; FONT-FAMILY: Times New Roman">&#8221;),
        Irides
        Acquisition Corporation (&#8220;</font><font style="DISPLAY: inline; FONT-SIZE: 9pt; FONT-FAMILY: Times New Roman"><em><u>Irides</u></em></font><font style="DISPLAY: inline; FONT-SIZE: 9pt; FONT-FAMILY: Times New Roman">&#8221;),
        a
        wholly-owned subsidiary of the Registrant and Icoria, Inc. (&#8220;</font><font style="DISPLAY: inline; FONT-SIZE: 9pt; FONT-FAMILY: Times New Roman"><em><u>Icoria</u></em></font><font style="DISPLAY: inline; FONT-SIZE: 9pt; FONT-FAMILY: Times New Roman">&#8221;),
        Irides
        was merged with and into Icoria with Icoria becoming a wholly-owned subsidiary
        of the Registrant (the &#8220;</font><font style="DISPLAY: inline; FONT-SIZE: 9pt; FONT-FAMILY: Times New Roman"><em><u>Merger</u></em></font><font style="DISPLAY: inline; FONT-SIZE: 9pt; FONT-FAMILY: Times New Roman">&#8221;).
        Under
        the terms of the Merger Agreement, each outstanding option previously granted
        by
        Icoria was assumed by the Registrant and became exercisable for that number
        of
        shares of the Registrant&#8217;s common stock equal to the number of shares of Icoria
        common stock that were issuable upon exercise of the option immediately prior
        to
        the Merger multiplied by 0.01552 rounded down to the nearest whole share
        number,
        and the per share exercise price was adjusted to equal the exercise price
        for
        which the option was exercisable immediately prior to the Merger divided
        by
        0.01552, rounded up to the nearest whole cent.</font></div>
      <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 0pt" align="justify">&#160;</div>
      <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 0pt" align="center"><font style="DISPLAY: inline; FONT-SIZE: 9pt; FONT-FAMILY: Times New Roman"><strong>PART
        I</strong></font></div>
      <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 0pt" align="justify">&#160;</div>
      <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 0pt" align="center"><font style="DISPLAY: inline; FONT-SIZE: 9pt; FONT-FAMILY: Times New Roman"><strong>INFORMATION
        REQUIRED IN THE SECTION 10(a) PROSPECTUS</strong></font></div>
      <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 0pt" align="justify">&#160;</div>
      <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 36pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 0pt" align="left"><font style="DISPLAY: inline; FONT-SIZE: 9pt; FONT-FAMILY: Times New Roman">The
        information required by Part I is included in the documents sent or given
        to
        participants in the plans covered by this registration statement pursuant
        to
        Rule 428(b)(1) of the Securities Act of 1933, as amended (the &#8220;</font><font style="DISPLAY: inline; FONT-SIZE: 9pt; FONT-FAMILY: Times New Roman"><em><u>Securities
        Act</u></em></font><font style="DISPLAY: inline; FONT-SIZE: 9pt; FONT-FAMILY: Times New Roman">&#8221;).</font></div>
      <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 0pt" align="justify">&#160;</div>
      <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 0pt" align="center"><font style="DISPLAY: inline; FONT-SIZE: 9pt; FONT-FAMILY: Times New Roman"><strong>PART
        II</strong></font></div>
      <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 0pt" align="justify">&#160;</div>
      <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 0pt" align="center"><font style="DISPLAY: inline; FONT-SIZE: 9pt; FONT-FAMILY: Times New Roman"><strong>INFORMATION
        REQUIRED IN THE REGISTRATION STATEMENT</strong></font></div>
      <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 0pt" align="justify">&#160;</div>
      <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 0pt" align="left"><font style="DISPLAY: inline; FONT-SIZE: 9pt; FONT-FAMILY: Times New Roman"><strong>Item&#160;3.<font id="TAB2" style="LETTER-SPACING: 9pt">&#160;&#160;&#160;</font>&#160;</strong></font><font style="DISPLAY: inline; FONT-SIZE: 9pt; FONT-FAMILY: Times New Roman"><strong>Incorporation
        of Documents By Reference.</strong></font></div>
      <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 0pt" align="justify">&#160;</div>
      <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 36pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 0pt" align="left"><font style="DISPLAY: inline; FONT-SIZE: 9pt; FONT-FAMILY: Times New Roman">The
        following documents filed by the Registrant with the Securities and Exchange
        Commission (the &#8220;</font><font style="DISPLAY: inline; FONT-SIZE: 9pt; FONT-FAMILY: Times New Roman"><em><u>Commission</u></em></font><font style="DISPLAY: inline; FONT-SIZE: 9pt; FONT-FAMILY: Times New Roman">&#8221;),
        pursuant to the Securities Exchange Act of 1934, as amended (the &#8220;</font><font style="DISPLAY: inline; FONT-SIZE: 9pt; FONT-FAMILY: Times New Roman"><em><u>Exchange
        Act</u></em></font><font style="DISPLAY: inline; FONT-SIZE: 9pt; FONT-FAMILY: Times New Roman">&#8221;),
        are
        incorporated by reference herein and shall be deemed as part
        hereof:</font></div>
      <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 0pt" align="justify">&#160;</div>
      <div>
        <table cellpadding="0" cellspacing="0" id="list" width="100%">

            <tr valign="top" style="line-height: 1.25;">
              <td align="right" style="width: 72pt;"><font style="DISPLAY: inline; FONT-SIZE: 9pt; FONT-FAMILY: Times New Roman">(a)&#160;&#160;</font></td>
              <td>
                <div style="MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt" align="justify"><font style="DISPLAY: inline; FONT-SIZE: 9pt; FONT-FAMILY: Times New Roman">the
                  Registrant&#8217;s Annual Report on Form 10-KSB for the fiscal year ended March
                  31, 2005, filed with the SEC on June 27,
                  2005;</font></div>
              </td>
            </tr>

        </table>
      </div>
      <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 0pt" align="justify">&#160;</div>
      <div>
        <table cellpadding="0" cellspacing="0" id="list" width="100%">

            <tr valign="top" style="line-height: 1.25;">
              <td align="right" style="width: 72pt;"><font style="DISPLAY: inline; FONT-SIZE: 9pt; FONT-FAMILY: Times New Roman">(b)&#160;&#160;</font></td>
              <td>
                <div style="MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt" align="justify"><font style="DISPLAY: inline; FONT-SIZE: 9pt; FONT-FAMILY: Times New Roman">the
                  Registrant&#8217;s Quarterly Reports on Form 10-Q for the quarter ended June 30,
                  2005, filed with the SEC on August 15, 2005, and for the quarter
                  ended
                  September 30, 2005, filed with the SEC on November 14,
                  2005;</font></div>
              </td>
            </tr>

        </table>
      </div>
      <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 0pt" align="justify">&#160;</div>
      <div>
        <table cellpadding="0" cellspacing="0" id="list" width="100%" style="MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt">

            <tr valign="top" style="line-height: 1.25;">
              <td align="right" style="width: 72pt;"><font style="DISPLAY: inline; FONT-SIZE: 9pt; FONT-FAMILY: Times New Roman">(c)&#160;&#160;</font></td>
              <td>
                <div style="MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt" align="justify"><font style="DISPLAY: inline; FONT-SIZE: 9pt; FONT-FAMILY: Times New Roman">the
                  Registrant&#8217;s Current Reports on Form 8-K, filed on April 21, 2005, June
                  21, 2005, June 24, 2005, July 11, 2005, August 2, 2005, September
                  20,
                  2005, September 22, 2005, September 28, 2005, October 11, 2005
                  (as amended
                  on November 9, 2005), October 21, 2005, November 1, 2005 (as to
                  Item 8.01
                  only), November 22, 2005 and December 27, 2005;
                  and</font></div>
              </td>
            </tr>

        </table>
      </div>
      <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 0pt" align="justify">&#160;</div>
      <div>
        <table cellpadding="0" cellspacing="0" id="list" width="100%">

            <tr valign="top" style="line-height: 1.25;">
              <td align="right" style="width: 72pt;"><font style="DISPLAY: inline; FONT-SIZE: 9pt; FONT-FAMILY: Times New Roman">(d)&#160;&#160;</font></td>
              <td>
                <div style="MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt" align="justify"><font style="DISPLAY: inline; FONT-SIZE: 9pt; FONT-FAMILY: Times New Roman">the
                  description of the Registrant&#8217;s Common Stock, par value $0.01 per share,
                  contained in the Section entitled &#8220;Description of Clinical Data Capital
                  Stock - Clinical Data Common Stock&#8221;, incorporated by reference from the
                  Registrant&#8217;s Registration Statement on Form S-4, including the prospectus
                  contained therein, filed with the Commission on October 27, 2005,
                  including any amendment or report filed hereafter for the purpose
                  of
                  updating such description.</font></div>
              </td>
            </tr>

        </table>
      </div>
      <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 0pt" align="justify">&#160;</div>
      <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 36pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 0pt" align="left"><font style="DISPLAY: inline; FONT-SIZE: 9pt; FONT-FAMILY: Times New Roman">All
        documents subsequently filed by the Registrant pursuant to Sections 13(a),
        13(c), 14 and 15(d) of the Exchange Act, prior to the filing of a post-effective
        amendment which indicates that all securities offered have been sold or which
        deregisters all securities then remaining unsold, shall be deemed to be
        incorporated by reference herein and to be a part hereof from the date of
        filing
        of such documents.</font></div>
      <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 0pt" align="justify">&#160;</div>
      <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 36pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 0pt" align="left"><font style="DISPLAY: inline; FONT-SIZE: 9pt; FONT-FAMILY: Times New Roman">Any
        statement contained in a document incorporated or deemed to be incorporated
        by
        reference herein shall be deemed to be modified or superseded for purposes
        of
        this Registration Statement to the extent that a statement contained herein
        or
        in any other subsequently filed document which also is or is deemed to be
        incorporated by reference herein modifies or supersedes such statement. Any
        such
        statement so modified or </font></div>
      <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 36pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 0pt" align="left">&#160;</div>
      <div id="PGBRK" style="MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt">
        <div id="FTR">
          <div id="GLFTR" style="WIDTH: 100%" align="left">
          </div>
        </div>
        <div id="PN" style="PAGE-BREAK-AFTER: always">
          <div style="WIDTH: 100%; TEXT-ALIGN: center"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman">-1-</font></div>
          <div style="WIDTH: 100%; TEXT-ALIGN: center">
            <hr style="COLOR: black" noshade size="2">
          </div>
        </div>
        <div id="HDR">
          <div id="GLHDR" style="WIDTH: 100%" align="right">
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        </div>
      </div>
      <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 0pt" align="left"><font style="DISPLAY: inline; FONT-SIZE: 9pt; FONT-FAMILY: Times New Roman">superseded
        shall not be deemed, except as so modified or superseded, to constitute a
        part
        of this Registration Statement.</font></div>
      <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 0pt" align="justify">&#160;</div>
      <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 0pt" align="left"><font style="DISPLAY: inline; FONT-SIZE: 9pt; FONT-FAMILY: Times New Roman"><strong>Item&#160;4.<font id="TAB2" style="LETTER-SPACING: 9pt">&#160;&#160;&#160;</font>&#160;</strong></font><font style="DISPLAY: inline; FONT-SIZE: 9pt; FONT-FAMILY: Times New Roman"><strong>Description
        of Securities.</strong></font></div>
      <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 0pt" align="justify">&#160;</div>
      <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 0pt" align="left"><font id="TAB1" style="MARGIN-LEFT: 36pt"></font><font style="DISPLAY: inline; FONT-SIZE: 9pt; FONT-FAMILY: Times New Roman">Not
        applicable.</font></div>
      <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 0pt" align="justify">&#160;</div>
      <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 0pt" align="left"><font style="DISPLAY: inline; FONT-SIZE: 9pt; FONT-FAMILY: Times New Roman"><strong>Item&#160;5.<font id="TAB2" style="LETTER-SPACING: 9pt">&#160;&#160;&#160;</font>&#160;</strong></font><font style="DISPLAY: inline; FONT-SIZE: 9pt; FONT-FAMILY: Times New Roman"><strong>Interests
        of Named Experts and Counsel.</strong></font></div>
      <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 0pt" align="justify">&#160;</div>
      <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 0pt" align="left"><font id="TAB1" style="MARGIN-LEFT: 36pt"></font><font style="DISPLAY: inline; FONT-SIZE: 9pt; FONT-FAMILY: Times New Roman">Not
        applicable.</font></div>
      <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 0pt" align="justify">&#160;</div>
      <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 0pt" align="left"><font style="DISPLAY: inline; FONT-SIZE: 9pt; FONT-FAMILY: Times New Roman"><strong>Item&#160;6.<font id="TAB2" style="LETTER-SPACING: 9pt">&#160;&#160;&#160;</font>&#160;</strong></font><font style="DISPLAY: inline; FONT-SIZE: 9pt; FONT-FAMILY: Times New Roman"><strong>Indemnification
        of Directors and Officers.</strong></font></div>
      <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 0pt" align="justify">&#160;</div>
      <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 36pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 0pt" align="left"><font style="DISPLAY: inline; FONT-SIZE: 9pt; FONT-FAMILY: Times New Roman">The
        Registrant&#8217;s certificate of incorporation provides that the Registrant shall, to
        the fullest extent permitted by Section 145 of the Delaware General Corporation
        Law, indemnify any and all directors and officers which it shall have the
        power
        to indemnify from and against any and all of the expenses, liabilities or
        other
        matters referred to in or covered by Section 145 of the Delaware General
        Corporation Law. The Registrant&#8217;s certificate of incorporation also provides
        that such indemnification rights shall not be exclusive of any other rights
        to
        which those seeking indemnification may be entitled under any bylaw, agreement,
        vote of its stockholders or disinterested directors or otherwise. The
        Registrant&#8217;s certificate of incorporation additionally provides that, to the
        fullest extent permitted by Delaware law, a director of the Registrant shall
        not
        be liable to the Registrant or its stockholders for monetary damages for
        breach
        of fiduciary duty as a director.</font></div>
      <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 0pt" align="justify">&#160;</div>
      <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 36pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 0pt" align="left"><font style="DISPLAY: inline; FONT-SIZE: 9pt; FONT-FAMILY: Times New Roman">The
        Registrant&#8217;s amended and restated bylaws provide that the Registrant shall, to
        the fullest extent authorized by the General Corporation Law of the state
        of
        Delaware, indemnify any person who was or is a party or is threatened to
        be made
        a party to or is otherwise involved in any threatened, pending or completed
        action, suit or proceeding, whether civil, criminal, administrative,
        investigative or otherwise, and whether by or in the right of the Registrant,
        its stockholders, a third party or otherwise, by reason of the fact that
        such
        person is or was a director or officer of the Registrant, or is or was serving
        at the request of the Registrant as a director, officer, employee or agent
        of
        another corporation, partnership, joint venture, trust or other enterprise,
        including, without limitation, a charity or a non-profit organization or
        person,
        against all expenses (including, but not limited to attorneys&#8217; fees), liability,
        loss, judgments, fines, excise taxes, penalties and amounts paid in settlement
        actually and reasonably incurred by such person in connection with such action,
        suit or proceeding, including expenses incurred in seeking indemnification.
        No
        indemnification is available with respect to: (i) indemnification of any
        improper personal benefit which a director or officer is determined to have
        received and of the expenses of defending against an improper personal benefit
        claim unless the director or officer is successful on the merits in said
        defense, and (ii) indemnification of present or former officers, directors,
        employees or agents of a constituent corporation absorbed in a merger or
        consolidation transaction with the Registrant with respect to their activities
        prior to said transaction, unless specifically authorized by the Registrant&#8217;s
        board of directors or stockholders. The Registrant&#8217;s bylaws also provide that
        such indemnification rights shall not be exclusive of other indemnification
        rights to which those seeking indemnification may be entitled by law or under
        any bylaw, agreement, vote of its stockholders or directors or
        otherwise.</font></div>
      <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 0pt" align="justify">&#160;</div>
      <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 36pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 0pt" align="left"><font style="DISPLAY: inline; FONT-SIZE: 9pt; FONT-FAMILY: Times New Roman">The
        Registrant has entered into indemnification agreements with each of its current
        directors and officers, pursuant to which the Registrant agreed to indemnify
        each director and officer with respect to any expenses, judgments, fines,
        penalties, and amounts paid in settlement in connection with any claim, pending
        or completed action, suit or proceeding, or any inquiry or investigation,
        related to any actions taken by the director or officer related to their
        service
        to the Registrant as a director or officer.</font></div>
      <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 0pt" align="justify">&#160;</div>
      <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 36pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 0pt" align="left"><font style="DISPLAY: inline; FONT-SIZE: 9pt; FONT-FAMILY: Times New Roman">The
        Registrant maintains insurance on behalf of any person who is a director
        or
        officer against any loss arising from any claim asserted against him or her
        and
        incurred by him or her in any such capacity, subject to certain
        exclusions.</font></div>
      <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 0pt" align="justify">&#160;</div>
      <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 0pt" align="left"><font style="DISPLAY: inline; FONT-SIZE: 9pt; FONT-FAMILY: Times New Roman"><strong>Item&#160;7.<font id="TAB2" style="LETTER-SPACING: 9pt">&#160;&#160;&#160;</font>&#160;</strong></font><font style="DISPLAY: inline; FONT-SIZE: 9pt; FONT-FAMILY: Times New Roman"><strong>Exemption
        from Registration Claimed.</strong></font></div>
      <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 0pt" align="justify">&#160;</div>
      <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 0pt" align="left"><font id="TAB1" style="MARGIN-LEFT: 36pt"></font><font style="DISPLAY: inline; FONT-SIZE: 9pt; FONT-FAMILY: Times New Roman">Not
        applicable.</font></div>
      <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 0pt" align="justify">&#160;</div>
      <div id="PGBRK" style="MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt">
        <div id="FTR">
          <div id="GLFTR" style="WIDTH: 100%" align="left">
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        Exhibit Index immediately following the signature pages is incorporated by
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        file,
        during any period in which offers or sales are being made, a post-effective
        amendment to this registration statement:</font></div>
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        in the prospectus any facts or events arising after the effective date of
        this
        registration statement (or the most recent post-effective amendment thereof)
        which, individually or in the aggregate, represent a fundamental change in
        the
        information set forth in the registration statement. Notwithstanding the
        foregoing, any increase or decrease in volume of securities offered (if the
        total dollar value of securities offered would not exceed that which was
        registered) and any deviation from the low or high end of the estimated maximum
        offering range may be reflected in the form of prospectus filed with the
        Commission pursuant to Rule 424(b) if, in the aggregate, the changes in volume
        and price represent no more than a 20 percent change in the maximum aggregate
        offering price set forth in the &#8220;Calculation of Registration Fee&#8221; table in the
        registration statement;</font></div>
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        disclosed in the registration statement or any material change to such
        information in the registration statement.</font></div>
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        that</font></div>
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        (a)(1)(i) and (a)(1)(ii) of this section do not apply if the registration
        statement is on Form S-8, and the information required to be included in
        a
        post-effective amendment by those paragraphs is contained in reports filed
        with
        or furnished to the Commission by the Registrant pursuant to Section 13 or
        15(d)
        of the Securities Exchange Act of 1934 that are incorporated by reference
        in the
        registration statement.</font></div>
      <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 0pt" align="justify">&#160;</div>
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        for
        the purpose of determining any liability under the Securities Act of 1933,
        each
        such post-effective amendment shall be deemed to be a new registration statement
        relating to the securities offered therein, and the offering of such securities
        at that time shall be deemed to be the initial bona fide offering
        thereof.</font></div>
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      <div style="DISPLAY: block; MARGIN-LEFT: 36pt; TEXT-INDENT: 36pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 0pt" align="left"><font style="DISPLAY: inline; FONT-SIZE: 9pt; FONT-FAMILY: Times New Roman">(3)</font><font id="TAB2" style="COLOR: black; LETTER-SPACING: 27pt">&#160;</font><font style="DISPLAY: inline; FONT-SIZE: 9pt; FONT-FAMILY: Times New Roman">To
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        from registration by means of a post-effective amendment any of the securities
        being registered which remain unsold at the termination of the
        offering.</font></div>
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      <div style="DISPLAY: block; MARGIN-LEFT: 36pt; TEXT-INDENT: 36pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 0pt" align="left"><font style="DISPLAY: inline; FONT-SIZE: 9pt; FONT-FAMILY: Times New Roman">(b)</font><font id="TAB2" style="COLOR: black; LETTER-SPACING: 27pt">&#160;</font><font style="DISPLAY: inline; FONT-SIZE: 9pt; FONT-FAMILY: Times New Roman">The
        undersigned Registrant hereby undertakes that, for purposes of determining
        any
        liability under the Securities Act of 1933, each filing of the Registrant&#8217;s
        annual report pursuant to Section 13(a) or Section 15(d) of the Securities
        Exchange Act of 1934 (and, where applicable, each filing of an employee benefit
        plan&#8217;s annual report pursuant to Section 15(d) of the Securities Exchange Act
        of
        1934) that is incorporated by reference in the registration statement shall
        be
        deemed to be a new registration statement relating to the securities offered
        therein, and the offering of such securities at that time shall be deemed
        to be
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      <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 0pt" align="justify">&#160;</div>
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        as
        indemnification for liabilities arising under the Securities Act of 1933
        may be
        permitted to directors, officers and controlling persons of the Registrant
        pursuant to the foregoing provisions, or otherwise, the Registrant has been
        advised that in the opinion of the Securities and Exchange </font></div>
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      <div id="PGBRK" style="MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt">
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        <div id="PN" style="PAGE-BREAK-AFTER: always">
          <div style="WIDTH: 100%; TEXT-ALIGN: center"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman">-3-</font></div>
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      <div style="DISPLAY: block; MARGIN-LEFT: 36pt; TEXT-INDENT: 0pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 0pt" align="left"><font style="DISPLAY: inline; FONT-SIZE: 9pt; FONT-FAMILY: Times New Roman">Commission
        such indemnification is against public policy as expressed in the Securities
        Act
        of 1933 and is, therefore, unenforceable. In the event that a claim for
        indemnification against such liabilities (other than the payment by the
        Registrant of expenses incurred or paid by a director, officer or controlling
        person of the Registrant in the successful defense of any action, suit or
        proceeding) is asserted by such director, officer or controlling person in
        connection with the securities being registered, the Registrant will, unless
        in
        the opinion of its counsel the matter has been settled by controlling precedent,
        submit to a court of appropriate jurisdiction the question whether such
        indemnification by it is against public policy as expressed in the Act and
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      <div style="DISPLAY: block; MARGIN-LEFT: 36pt; TEXT-INDENT: 0pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 0pt" align="left">&#160;</div>
      <div style="DISPLAY: block; MARGIN-LEFT: 36pt; TEXT-INDENT: 0pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 0pt" align="left">&#160;</div>
      <div style="DISPLAY: block; MARGIN-LEFT: 36pt; TEXT-INDENT: 0pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 0pt" align="left">&#160;</div>
      <div style="DISPLAY: block; MARGIN-LEFT: 36pt; TEXT-INDENT: 0pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 0pt" align="left">&#160;</div>
      <div style="DISPLAY: block; MARGIN-LEFT: 36pt; TEXT-INDENT: 0pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 0pt" align="left">&#160;</div>
      <div style="DISPLAY: block; MARGIN-LEFT: 36pt; TEXT-INDENT: 0pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 0pt" align="left">&#160;</div>
      <div style="DISPLAY: block; MARGIN-LEFT: 36pt; TEXT-INDENT: 0pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 0pt" align="left">&#160;</div>
      <div style="DISPLAY: block; MARGIN-LEFT: 36pt; TEXT-INDENT: 0pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 0pt" align="left">&#160;</div>
      <div style="DISPLAY: block; MARGIN-LEFT: 36pt; TEXT-INDENT: 0pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 0pt" align="left">&#160;</div>
      <div style="DISPLAY: block; MARGIN-LEFT: 36pt; TEXT-INDENT: 0pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 0pt" align="left">&#160;</div>
      <div style="DISPLAY: block; MARGIN-LEFT: 36pt; TEXT-INDENT: 0pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 0pt" align="left">&#160;</div>
      <div style="DISPLAY: block; MARGIN-LEFT: 36pt; TEXT-INDENT: 0pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 0pt" align="left">&#160;</div>
      <div style="DISPLAY: block; MARGIN-LEFT: 36pt; TEXT-INDENT: 0pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 0pt" align="left">&#160;</div>
      <div style="DISPLAY: block; MARGIN-LEFT: 36pt; TEXT-INDENT: 0pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 0pt" align="left">&#160;</div>
      <div style="DISPLAY: block; MARGIN-LEFT: 36pt; TEXT-INDENT: 36pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 0pt" align="left">&#160;</div>
      <div id="PGBRK" style="MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt">
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          <div id="GLFTR" style="WIDTH: 100%" align="left">
          </div>
        </div>
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          <div style="WIDTH: 100%; TEXT-ALIGN: center"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman">-4-</font></div>
          <div style="WIDTH: 100%; TEXT-ALIGN: center">
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      <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 0pt" align="center"><font style="DISPLAY: inline; FONT-SIZE: 9pt; FONT-FAMILY: Times New Roman"><strong>SIGNATURES</strong></font></div>
      <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 0pt" align="justify">&#160;</div>
      <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 0pt" align="left"><font style="DISPLAY: inline; FONT-SIZE: 9pt; FONT-FAMILY: Times New Roman">Pursuant
        to the requirements of the Securities Act of 1933, as amended, the Registrant
        certifies that it has reasonable grounds to believe that it meets all of
        the
        requirements for filing on Form S-8 and has duly caused this Registration
        Statement to be signed on its behalf by the undersigned, thereunto duly
        authorized, in the Town of Smithfield, State of Rhode Island, on January
        13,
        2006.</font></div>
      <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 0pt" align="justify">&#160;</div>
      <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 0pt" align="justify">
        <table align="center" bgcolor="#ffffff" border="0" cellpadding="0" cellspacing="0" width="100%">

            <tr valign="top" bgcolor="#ffffff">
              <td width="50%"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: ">&#160;</font></td>
              <td width="1%"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: ">&#160;</font></td>
              <td width="49%"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: ">&#160;</font></td>
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                DATA,
                INC.</font></td>
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              <td><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: ">&#160;<br>&#160;</font></td>
              <td><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: ">&#160;<br>&#160;</font></td>
              <td><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: ">&#160;<br>&#160;</font></td>
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              <td><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: ">/s/&#160;Israel
                M.
                Stein</font></td>
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                  M. Stein, M.D.</font></div>
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                  and Chief Executive Officer</em></font></div>
                <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 0pt" align="left"><font style="DISPLAY: inline; FONT-SIZE: 9pt; FONT-FAMILY: Times New Roman"><em>Principal
                  Executive Officer</em></font>&#160;</div>
              </td>
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      <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 0pt" align="left">
        <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 0pt" align="justify">
          <table align="center" bgcolor="#ffffff" border="0" cellpadding="0" cellspacing="0" width="100%">

              <tr valign="top" bgcolor="#ffffff">
                <td width="50%"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: ">&#160;</font></td>
                <td width="1%"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: ">&#160;</font></td>
                <td width="49%"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: ">&#160;</font></td>
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                <td><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: ">&#160;<br>&#160;</font></td>
                <td><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: ">&#160;<br>&#160;</font></td>
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                <td><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: ">/s/&#160;<font style="DISPLAY: inline; FONT-SIZE: 9pt; FONT-FAMILY: Times New Roman">Mark
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                      Vice President and Chief Financial Officer</em></font></div>
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                      Officer</em></font></div>
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                </td>
              </tr>

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        <div style="DISPLAY: block; MARGIN-LEFT: 216pt; TEXT-INDENT: 0pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 0pt" align="left">&#160;</div>
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        OF ATTORNEY</strong></font></div>
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        person whose signature appears below hereby constitutes and appoints Israel
        M.
        Stein, M.D. and Caesar J. Belbel or either of them, his true and lawful
        attorneys and agent, with full power of substitution, and with power to act
        alone, to sign on behalf of the undersigned any amendment or amendments to
        this
        registration statement on Form S-8 (including pre- and post-effective
        amendments) and to perform any acts necessary to file such amendments, with
        exhibits thereto and other documents in connection therewith, and each of
        the
        undersigned does hereby ratify and confirm his signature as it may be signed
        by
        his said attorneys and agents to any and all such documents and all that
        said
        attorneys and agents, or their substitutes, shall do or cause to be done
        by
        virtue hereof.</font></div>
      <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 0pt" align="justify">&#160;</div>
      <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 0pt" align="left"><font id="TAB1" style="MARGIN-LEFT: 36pt"></font><font style="DISPLAY: inline; FONT-SIZE: 9pt; FONT-FAMILY: Times New Roman">Pursuant
        to the requirements of the Securities Act of 1933, this registration statement
        has been signed by the following persons in the capacities and as of the
        dates
        indicated.</font></div>
      <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 0pt" align="justify">&#160;</div>
      <div align="center">
        <table border="0" cellpadding="0" cellspacing="0" width="100%">

            <tr>
              <td valign="top" width="33%" style="border-bottom: medium none;">
                <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 0pt" align="center"><font style="DISPLAY: inline; FONT-SIZE: 9pt; FONT-FAMILY: Times New Roman"><strong>Signature</strong></font></div>
              </td>
              <td valign="top" width="33%" style="border-bottom: medium none;">
                <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 0pt" align="center"><font style="DISPLAY: inline; FONT-SIZE: 9pt; FONT-FAMILY: Times New Roman"><strong>Title</strong></font></div>
              </td>
              <td valign="top" width="33%" style="border-bottom: medium none;">
                <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 0pt" align="center"><font style="DISPLAY: inline; FONT-SIZE: 9pt; FONT-FAMILY: Times New Roman"><strong>Date</strong></font></div>
              </td>
            </tr>
            <tr>
              <td align="left" valign="top" width="33%" style="border-bottom: medium none;">&#160;</td>
              <td align="left" valign="top" width="33%" style="border-bottom: medium none;">&#160;</td>
              <td align="left" valign="top" width="33%" style="border-bottom: medium none;">&#160;</td>
            </tr>
            <tr>
              <td valign="top" width="33%" style="border-bottom: medium none;">
                <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 9.3pt" align="center">&#160;
/s/
<font style="DISPLAY: inline; FONT-SIZE: 9pt; FONT-FAMILY: Times New Roman">Randal
                  J. Kirk</font>
                  <hr style="COLOR: black" align="center" noshade size="1" width="50%">
                </div>
                <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 0pt" align="center"><font style="DISPLAY: inline; FONT-SIZE: 9pt; FONT-FAMILY: Times New Roman">Randal
                  J. Kirk</font></div>
              </td>
              <td align="left" valign="top" width="33%" style="border-bottom: medium none;">
                <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 0pt" align="left"><font style="DISPLAY: inline; FONT-SIZE: 9pt; FONT-FAMILY: Times New Roman">Chairman
                  of the Board</font></div>
              </td>
              <td align="left" valign="top" width="33%" style="border-bottom: medium none;">
                <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 0pt" align="center"><font style="DISPLAY: inline; FONT-SIZE: 9pt; FONT-FAMILY: Times New Roman"><strong>January
                  13, 2006</strong></font></div>
              </td>
            </tr>
            <tr>
              <td valign="top" width="33%" style="border-bottom: medium none;">&#160;</td>
              <td align="left" valign="top" width="33%" style="border-bottom: medium none;">&#160;</td>
              <td align="left" valign="top" width="33%" style="border-bottom: medium none;">&#160;</td>
            </tr>
            <tr>
              <td valign="top" width="33%" style="border-bottom: medium none;">
                <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 9.3pt" align="center">/s/
<font size="2">Israel
                  M. Stein</font>&#160;&#160;

                  <hr style="COLOR: black" align="center" noshade size="1" width="50%">
                </div>
                <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 0pt" align="center"><font style="DISPLAY: inline; FONT-SIZE: 9pt; FONT-FAMILY: Times New Roman">Israel
                  M. Stein, M.D.</font></div>
              </td>
              <td align="left" valign="top" width="33%" style="border-bottom: medium none;">
                <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 0pt" align="left"><font style="DISPLAY: inline; FONT-SIZE: 9pt; FONT-FAMILY: Times New Roman">President,
                  Chief Executive Officer </font></div>
                <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 0pt" align="left"><font style="DISPLAY: inline; FONT-SIZE: 9pt; FONT-FAMILY: Times New Roman">and
                  Director (Principal Executive </font></div>
                <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 0pt" align="left"><font style="DISPLAY: inline; FONT-SIZE: 9pt; FONT-FAMILY: Times New Roman">Officer)</font></div>
              </td>
              <td align="left" valign="top" width="33%" style="border-bottom: medium none;">
                <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 0pt" align="center"><font style="DISPLAY: inline; FONT-SIZE: 9pt; FONT-FAMILY: Times New Roman"><strong>January
                  13, 2006</strong></font></div>
              </td>
            </tr>
            <tr>
              <td valign="top" width="33%" style="border-bottom: medium none;">&#160;</td>
              <td align="left" valign="top" width="33%" style="border-bottom: medium none;">&#160;</td>
              <td align="left" valign="top" width="33%" style="border-bottom: medium none;">&#160;</td>
            </tr>
            <tr>
              <td valign="top" width="33%" style="border-bottom: medium none;">
                <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 9.3pt" align="center">&#160;
/s/
<font style="DISPLAY: inline; FONT-SIZE: 9pt; FONT-FAMILY: Times New Roman">Larry
                  D. Horner</font>
                  <hr style="COLOR: black" align="center" noshade size="1" width="50%">
                </div>
                <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 0pt" align="center"><font style="DISPLAY: inline; FONT-SIZE: 9pt; FONT-FAMILY: Times New Roman">Larry
                  D. Horner</font></div>
              </td>
              <td align="left" valign="top" width="33%" style="border-bottom: medium none;">
                <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 0pt" align="left"><font style="DISPLAY: inline; FONT-SIZE: 9pt; FONT-FAMILY: Times New Roman">Director</font></div>
              </td>
              <td align="left" valign="top" width="33%" style="border-bottom: medium none;">
                <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 0pt" align="center"><font style="DISPLAY: inline; FONT-SIZE: 9pt; FONT-FAMILY: Times New Roman"><strong>January
                  13, 2006</strong></font></div>
              </td>
            </tr>
            <tr>
              <td valign="top" width="33%" style="border-bottom: medium none;">&#160;</td>
              <td align="left" valign="top" width="33%" style="border-bottom: medium none;">&#160;</td>
              <td align="left" valign="top" width="33%" style="border-bottom: medium none;">&#160;</td>
            </tr>
            <tr>
              <td valign="top" width="33%" style="border-bottom: medium none;">
                <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 9.3pt" align="center">&#160;
/s/
<font style="DISPLAY: inline; FONT-SIZE: 9pt; FONT-FAMILY: Times New Roman">Arthur
                  B. Malman</font>
                  <hr style="COLOR: black" align="center" noshade size="1" width="50%">
                </div>
                <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 0pt" align="center"><font style="DISPLAY: inline; FONT-SIZE: 9pt; FONT-FAMILY: Times New Roman">Arthur
                  B. Malman</font></div>
              </td>
              <td align="left" valign="top" width="33%" style="border-bottom: medium none;">
                <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 0pt" align="left"><font style="DISPLAY: inline; FONT-SIZE: 9pt; FONT-FAMILY: Times New Roman">Director</font></div>
              </td>
              <td align="left" valign="top" width="33%" style="border-bottom: medium none;">
                <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 0pt" align="center"><font style="DISPLAY: inline; FONT-SIZE: 9pt; FONT-FAMILY: Times New Roman"><strong>January
                  13, 2006</strong></font></div>
              </td>
            </tr>
            <tr>
              <td align="left" valign="top" width="33%" style="border-bottom: medium none;">&#160;</td>
              <td align="left" valign="top" width="33%" style="border-bottom: medium none;">&#160;</td>
              <td align="left" valign="top" width="33%" style="border-bottom: medium none;">&#160;</td>
            </tr>
            <tr>
              <td valign="top" width="33%" style="border-bottom: medium none;">
                <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 9.3pt" align="center">&#160;
/s/
<font style="DISPLAY: inline; FONT-SIZE: 9pt; FONT-FAMILY: Times New Roman">Burton
                  Sobel</font>
                  <hr style="COLOR: black" align="center" noshade size="1" width="50%">
                </div>
                <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 0pt" align="center"><font style="DISPLAY: inline; FONT-SIZE: 9pt; FONT-FAMILY: Times New Roman">Burton
                  Sobel</font></div>
              </td>
              <td align="left" valign="top" width="33%" style="border-bottom: medium none;">
                <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 0pt" align="left"><font style="DISPLAY: inline; FONT-SIZE: 9pt; FONT-FAMILY: Times New Roman">Director</font></div>
              </td>
              <td align="left" valign="top" width="33%" style="border-bottom: medium none;">
                <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 0pt" align="center"><font style="DISPLAY: inline; FONT-SIZE: 9pt; FONT-FAMILY: Times New Roman"><strong>January
                  13, 2006</strong></font></div>
              </td>
            </tr>
            <tr>
              <td align="left" valign="top" width="33%" style="border-bottom: medium none;">&#160;</td>
              <td align="left" valign="top" width="33%" style="border-bottom: medium none;">&#160;</td>
              <td align="left" valign="top" width="33%" style="border-bottom: medium none;">&#160;</td>
            </tr>
            <tr>
              <td valign="top" width="33%" style="border-bottom: medium none;">
                <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 9.3pt" align="center">&#160;
/s/
<font style="DISPLAY: inline; FONT-SIZE: 9pt; FONT-FAMILY: Times New Roman">J</font><font style="DISPLAY: inline; FONT-SIZE: 9pt; FONT-FAMILY: Times New Roman">oseph</font><font style="DISPLAY: inline; FONT-SIZE: 9pt; FONT-FAMILY: Times New Roman">
                  K</font><font style="DISPLAY: inline; FONT-SIZE: 9pt; FONT-FAMILY: Times New Roman">lein</font><font style="DISPLAY: inline; FONT-SIZE: 9pt; FONT-FAMILY: Times New Roman">
                  III</font>
                  <hr style="COLOR: black" align="center" noshade size="1" width="50%">
                </div>
                <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 0pt" align="center"><font style="DISPLAY: inline; FONT-SIZE: 9pt; FONT-FAMILY: Times New Roman">J</font><font style="DISPLAY: inline; FONT-SIZE: 9pt; FONT-FAMILY: Times New Roman">oseph</font><font style="DISPLAY: inline; FONT-SIZE: 9pt; FONT-FAMILY: Times New Roman">
                  K</font><font style="DISPLAY: inline; FONT-SIZE: 9pt; FONT-FAMILY: Times New Roman">lein</font><font style="DISPLAY: inline; FONT-SIZE: 9pt; FONT-FAMILY: Times New Roman">
                  III</font></div>
              </td>
              <td align="left" valign="top" width="33%" style="border-bottom: medium none;">
                <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 0pt" align="left"><font style="DISPLAY: inline; FONT-SIZE: 9pt; FONT-FAMILY: Times New Roman">Director</font></div>
              </td>
              <td align="left" valign="top" width="33%" style="border-bottom: medium none;">
                <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 0pt" align="center"><font style="DISPLAY: inline; FONT-SIZE: 9pt; FONT-FAMILY: Times New Roman"><strong>January
                  13, 2006</strong></font></div>
              </td>
            </tr>
            <tr>
              <td align="left" valign="top" width="33%" style="border-bottom: medium none;">&#160;</td>
              <td align="left" valign="top" width="33%" style="border-bottom: medium none;">&#160;</td>
              <td align="left" valign="top" width="33%" style="border-bottom: medium none;">&#160;</td>
            </tr>
            <tr>
              <td valign="top" width="33%" style="border-bottom: medium none;">
                <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 9.3pt" align="center">/s/
<font style="DISPLAY: inline; FONT-SIZE: 9pt; FONT-FAMILY: Times New Roman">K</font><font style="DISPLAY: inline; FONT-SIZE: 9pt; FONT-FAMILY: Times New Roman">evin</font><font style="DISPLAY: inline; FONT-SIZE: 9pt; FONT-FAMILY: Times New Roman">
                  R</font><font style="DISPLAY: inline; FONT-SIZE: 9pt; FONT-FAMILY: Times New Roman">akin</font>&#160;

                  <hr style="COLOR: black" align="center" noshade size="1" width="50%">
                </div>
                <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 0pt" align="center"><font style="DISPLAY: inline; FONT-SIZE: 9pt; FONT-FAMILY: Times New Roman">K</font><font style="DISPLAY: inline; FONT-SIZE: 9pt; FONT-FAMILY: Times New Roman">evin</font><font style="DISPLAY: inline; FONT-SIZE: 9pt; FONT-FAMILY: Times New Roman">
                  R</font><font style="DISPLAY: inline; FONT-SIZE: 9pt; FONT-FAMILY: Times New Roman">akin</font></div>
              </td>
              <td align="left" valign="top" width="33%" style="border-bottom: medium none;">
                <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 0pt" align="left"><font style="DISPLAY: inline; FONT-SIZE: 9pt; FONT-FAMILY: Times New Roman">Director</font></div>
              </td>
              <td align="left" valign="top" width="33%" style="border-bottom: medium none;">
                <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 0pt" align="center"><font style="DISPLAY: inline; FONT-SIZE: 9pt; FONT-FAMILY: Times New Roman"><strong>January
                  13, 2006</strong></font></div>
              </td>
            </tr>
            <tr>
              <td align="left" valign="top" width="33%" style="border-bottom: medium none;">&#160;</td>
              <td align="left" valign="top" width="33%" style="border-bottom: medium none;">&#160;</td>
              <td align="left" valign="top" width="33%" style="border-bottom: medium none;">&#160;</td>
            </tr>
            <tr>
              <td valign="top" width="33%" style="border-bottom: medium none;">
                <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 9.3pt" align="center">&#160;
/s/
<font style="DISPLAY: inline; FONT-SIZE: 9pt; FONT-FAMILY: Times New Roman">G.
                  S</font><font style="DISPLAY: inline; FONT-SIZE: 9pt; FONT-FAMILY: Times New Roman">teven
                  Burrill</font>
                  <hr style="COLOR: black" align="center" noshade size="1" width="50%">
                </div>
                <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 0pt" align="center"><font style="DISPLAY: inline; FONT-SIZE: 9pt; FONT-FAMILY: Times New Roman">G.
                  S</font><font style="DISPLAY: inline; FONT-SIZE: 9pt; FONT-FAMILY: Times New Roman">teven
                  Burrill</font></div>
              </td>
              <td align="left" valign="top" width="33%" style="border-bottom: medium none;">
                <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 0pt" align="left"><font style="DISPLAY: inline; FONT-SIZE: 9pt; FONT-FAMILY: Times New Roman">Director</font></div>
              </td>
              <td align="left" valign="top" width="33%" style="border-bottom: medium none;">
                <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 0pt" align="center"><font style="DISPLAY: inline; FONT-SIZE: 9pt; FONT-FAMILY: Times New Roman"><strong>January
                  13, 2006</strong></font></div>
              </td>
            </tr>

        </table>
      </div>
      <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 0pt" align="left"><br></div>
      <div id="PGBRK" style="MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt">
        <div id="FTR">
          <div id="GLFTR" style="WIDTH: 100%" align="left">
          </div>
        </div>
        <div id="PN" style="PAGE-BREAK-AFTER: always">
          <div style="WIDTH: 100%; TEXT-ALIGN: center"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman">II-1</font></div>
          <div style="WIDTH: 100%; TEXT-ALIGN: center">
            <hr style="COLOR: black" noshade size="2">
          </div>
        </div>
        <div id="HDR">
          <div id="GLHDR" style="WIDTH: 100%" align="right">
          </div>
        </div>
      </div>
      <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 0pt" align="center"><font style="DISPLAY: inline; FONT-SIZE: 9pt; FONT-FAMILY: Times New Roman"><strong>EXHIBIT
        INDEX</strong></font></div>
      <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 0pt" align="justify">&#160;</div>
      <div align="left">
        <table cellpadding="0" cellspacing="0" width="100%">

            <tr>
              <td valign="top" width="25%" style="border-bottom: medium none;">
                <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 0pt" align="center"><font style="DISPLAY: inline; FONT-SIZE: 9pt; FONT-FAMILY: Times New Roman"><strong><u>Exhibit
                  No.</u></strong></font></div>
              </td>
              <td valign="top" width="75%" style="border-bottom: medium none;">
                <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 0pt" align="center"><font style="DISPLAY: inline; FONT-SIZE: 9pt; FONT-FAMILY: Times New Roman"><strong><u>Description</u></strong></font></div>
              </td>
            </tr>
            <tr>
              <td valign="top" width="25%">&#160;</td>
              <td align="left" valign="top" width="75%">&#160;</td>
            </tr>
            <tr>
              <td valign="top" width="25%">
                <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 0pt" align="center"><font style="DISPLAY: inline; FONT-SIZE: 9pt; FONT-FAMILY: Times New Roman">4.1</font></div>
              </td>
              <td align="left" valign="top" width="75%">
                <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 0pt" align="left"><font style="DISPLAY: inline; FONT-SIZE: 9pt; FONT-FAMILY: Times New Roman">Certificate
                  of Incorporation. Filed as Exhibit 3.1 to Clinical Data&#8217;s Registration
                  Statement on Form S-1 (File No. 2-82494) filed on March 17, 1983,
                  and
                  incorporated herein by reference.</font></div>
              </td>
            </tr>
            <tr>
              <td valign="top" width="25%">&#160;</td>
              <td align="left" valign="top" width="75%">&#160;</td>
            </tr>
            <tr>
              <td valign="top" width="25%">
                <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 0pt" align="center"><font style="DISPLAY: inline; FONT-SIZE: 9pt; FONT-FAMILY: Times New Roman">4.2</font></div>
              </td>
              <td align="left" valign="top" width="75%">
                <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 0pt" align="left"><font style="DISPLAY: inline; FONT-SIZE: 9pt; FONT-FAMILY: Times New Roman">Certificate
                  of Amendment of Certificate of Incorporation. Filed as Exhibit
                  3.1 to
                  Clinical Data&#8217;s Quarterly Report on Form 10-QSB (File No. 000-12716) filed
                  on February 17, 2004, and incorporated herein by
                  reference.</font></div>
              </td>
            </tr>
            <tr>
              <td valign="top" width="25%">&#160;</td>
              <td align="left" valign="top" width="75%">&#160;</td>
            </tr>
            <tr>
              <td valign="top" width="25%">
                <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 0pt" align="center"><font style="DISPLAY: inline; FONT-SIZE: 9pt; FONT-FAMILY: Times New Roman">4.3</font></div>
              </td>
              <td align="left" valign="top" width="75%">
                <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 0pt" align="left"><font style="DISPLAY: inline; FONT-SIZE: 9pt; FONT-FAMILY: Times New Roman">Certificate
                  of Amendment to Certificate of Incorporation. Filed as Exhibit
                  3.1 to
                  Clinical Data&#8217;s Current Report on Form 8-K (File No. 000-12716) filed on
                  October 11, 2005, and incorporated herein by reference.</font></div>
              </td>
            </tr>
            <tr>
              <td valign="top" width="25%">&#160;</td>
              <td align="left" valign="top" width="75%">&#160;</td>
            </tr>
            <tr>
              <td valign="top" width="25%">
                <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 0pt" align="center"><font style="DISPLAY: inline; FONT-SIZE: 9pt; FONT-FAMILY: Times New Roman">4.4</font></div>
              </td>
              <td align="left" valign="top" width="75%">
                <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 0pt" align="left"><font style="DISPLAY: inline; FONT-SIZE: 9pt; FONT-FAMILY: Times New Roman">Amended
                  and Restated Bylaws of Clinical Data. Filed as Exhibit 3.1 to Clinical
                  Data&#8217;s Current Report on Form 8-K (File No. 000-12716) filed on June
                  24,
                  2005, and incorporated herein by reference.</font></div>
              </td>
            </tr>
            <tr>
              <td valign="top" width="25%">&#160;</td>
              <td align="left" valign="top" width="75%">&#160;</td>
            </tr>
            <tr>
              <td valign="top" width="25%">
                <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 0pt" align="center"><font style="DISPLAY: inline; FONT-SIZE: 9pt; FONT-FAMILY: Times New Roman">4.5</font></div>
              </td>
              <td align="left" valign="top" width="75%">
                <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 0pt" align="left"><font style="DISPLAY: inline; FONT-SIZE: 9pt; FONT-FAMILY: Times New Roman">Icoria,
                  Inc. 2003 Employee, Director and Consultant Stock Plan, as restated.
                  Filed
                  as Appendix B to the Definitive Proxy Statement on Schedule 14A
                  of
                  Paradigm Genetics, Inc. (File No. 000-30365) filed on March 31,
                  2004, and
                  incorporated herein by reference.</font></div>
              </td>
            </tr>
            <tr>
              <td valign="top" width="25%">&#160;</td>
              <td align="left" valign="top" width="75%">&#160;</td>
            </tr>
            <tr>
              <td valign="top" width="25%">
                <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 0pt" align="center"><font style="DISPLAY: inline; FONT-SIZE: 9pt; FONT-FAMILY: Times New Roman">4.6</font></div>
              </td>
              <td align="left" valign="top" width="75%">
                <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 0pt" align="left"><font style="DISPLAY: inline; FONT-SIZE: 9pt; FONT-FAMILY: Times New Roman">TissueInformatics.Inc
                  2001 Stock Option Plan. Filed as Exhibit 10.1 to the Form 10-Q
                  of Paradigm
                  Genetics, Inc. (File No. 000-30365) filed on May 17, 2004, and
                  incorporated herein by reference.</font></div>
              </td>
            </tr>
            <tr>
              <td valign="top" width="25%">&#160;</td>
              <td align="left" valign="top" width="75%">&#160;</td>
            </tr>
            <tr>
              <td valign="top" width="25%">
                <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 0pt" align="center"><font style="DISPLAY: inline; FONT-SIZE: 9pt; FONT-FAMILY: Times New Roman">5.1</font></div>
              </td>
              <td align="left" valign="top" width="75%">
                <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 0pt" align="left"><font style="DISPLAY: inline; FONT-SIZE: 9pt; FONT-FAMILY: Times New Roman">Opinion
                  of McDermott Will &amp; Emery LLP as to the validity of the common stock
                  of Clinical Data being registered hereby, together with
                  consent.</font></div>
              </td>
            </tr>
            <tr>
              <td valign="top" width="25%">&#160;</td>
              <td align="left" valign="top" width="75%">&#160;</td>
            </tr>
            <tr>
              <td valign="top" width="25%">
                <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 0pt" align="center"><font style="DISPLAY: inline; FONT-SIZE: 9pt; FONT-FAMILY: Times New Roman">23.1</font></div>
              </td>
              <td align="left" valign="top" width="75%">
                <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 0pt" align="left"><font style="DISPLAY: inline; FONT-SIZE: 9pt; FONT-FAMILY: Times New Roman">Consent
                  of Deloitte &amp; Touche LLP, Clinical Data&#8217;s independent registered
                  public accounting firm.</font></div>
              </td>
            </tr>
            <tr>
              <td valign="top" width="25%">&#160;</td>
              <td align="left" valign="top" width="75%">&#160;</td>
            </tr>
            <tr>
              <td valign="top" width="25%">
                <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 0pt" align="center"><font style="DISPLAY: inline; FONT-SIZE: 9pt; FONT-FAMILY: Times New Roman">23.2</font></div>
              </td>
              <td align="left" valign="top" width="75%">
                <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 0pt" align="left"><font style="DISPLAY: inline; FONT-SIZE: 9pt; FONT-FAMILY: Times New Roman">Consent
                  of PricewaterhouseCoopers LLP, Icoria&#8217;s independent registered public
                  accounting firm.</font></div>
              </td>
            </tr>
            <tr>
              <td valign="top" width="25%">&#160;</td>
              <td align="left" valign="top" width="75%">&#160;</td>
            </tr>
            <tr>
              <td valign="top" width="25%">
                <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 0pt" align="center"><font style="DISPLAY: inline; FONT-SIZE: 9pt; FONT-FAMILY: Times New Roman">23.3</font></div>
              </td>
              <td align="left" valign="top" width="75%">
                <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 0pt" align="left"><font style="DISPLAY: inline; FONT-SIZE: 9pt; FONT-FAMILY: Times New Roman">Consent
                  of PricewaterhouseCoopers LLP, Genaissance Pharmaceuticals, Inc.&#8217;s
                  independent registered public accounting firm.</font></div>
              </td>
            </tr>
            <tr>
              <td valign="top" width="25%">&#160;</td>
              <td align="left" valign="top" width="75%">&#160;</td>
            </tr>
            <tr>
              <td valign="top" width="25%">
                <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 0pt" align="center"><font style="DISPLAY: inline; FONT-SIZE: 9pt; FONT-FAMILY: Times New Roman">23.4</font></div>
              </td>
              <td align="justify" valign="top" width="75%">
                <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 0pt" align="justify"><font style="DISPLAY: inline; FONT-SIZE: 9pt; FONT-FAMILY: Times New Roman">Consent
                  of McDermott Will &amp; Emery LLP (included in Exhibit
                  5.1).</font></div>
              </td>
            </tr>
            <tr>
              <td valign="top" width="25%">&#160;</td>
              <td align="justify" valign="top" width="75%">&#160;</td>
            </tr>
            <tr>
              <td valign="top" width="25%">
                <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 0pt" align="center"><font style="DISPLAY: inline; FONT-SIZE: 9pt; FONT-FAMILY: Times New Roman">24.1</font></div>
              </td>
              <td align="left" valign="top" width="75%">
                <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 0pt" align="left"><font style="DISPLAY: inline; FONT-SIZE: 9pt; FONT-FAMILY: Times New Roman">Power
                  of Attorney (included in the signature page of this registration
                  statement).</font></div>
              </td>
            </tr>

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[{"type": "S-8", "sequence": "1", "filename": "form-s8_14080.htm", "description": "CLINICAL DATA, INC. FORM S-8", "secsgml_size_bytes": 107890}]
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WWW.EXFILE.COM, INC. -- 14080 -- CLINICAL DATA, INC. -- FORM 8-K
Registration
        No. 333-_____________
SECURITIES
        AND EXCHANGE COMMISSION
WASHINGTON,
        D.C. 20549
FORM
        S-8
REGISTRATION
        STATEMENT
UNDER
THE
        SECURITIES ACT OF 1933
CLINICAL
        DATA, INC.
(Exact
        name of Registrant as specified in its charter)
Delaware
04-2573920
(State
                  or Other Jurisdiction of Incorporation or Organization)
(I.R.S.
                  Employer Identification Number)
One
        Gateway Center, Suite 411
Newton,
        MA 02458
(617)
        527-9933
(Address
        of Principal Executive Offices, including Zip Code and Telephone
        Number)
Options
        assumed by Clinical Data, Inc. in connection with the merger of a wholly-owned
subsidiary
        of Clinical Data with Icoria, Inc., originally granted
        under
Icoria,
        Inc. 2003 Employee, Director and Consultant Stock Plan, as restated,
        and
TissueInformatics.Inc
        2001 Stock Option Plan
(Full
        Title of the Plan)
Israel
        M. Stein, M.D.
President
        and Chief Executive Officer
Clinical
        Data, Inc.
One
        Gateway Center, Suite 411
Newton,
        MA 02458
(617)
        527-9933
(Name,
        Address, including Zip Code, and Telephone Number,
including
        Area Code,
of
        Agent
        for Service)
(with
        a
        copy to)
John
        Hession
Marc
        Recht
McDermott
        Will & Emery LLP
28
        State
        Street
Boston,
        MA
        02109
(617)
        535-4000
CALCULATION
        OF REGISTRATION FEE
Title
                  of Securities to be Registered
Amount
                  to be
Registered(1)
Proposed
                  Maximum
Offering
                  Price
Per
                  Share(2)
Proposed
                  Maximum
Aggregate
                  Offering
Price(2)
Amount
                  of
Registration
Fee
Common
                  Stock, par value $0.01 per share
40,000
                  shares
$18.45
$737,800
$79
________________
(1)
Plus,
                  pursuant to Rule 416(a) under the Securities Act, such additional
                  number
                  of shares as may be required in the event of a stock dividend,
                  split-up of
                  shares or other similar change in the Common
                  Stock.
(2)
Estimated
                  solely for the purpose of computing the amount of the registration
                  fee
                  under Rules 457(c) and 457(h)(1) based on the average of the high
                  and low
                  price per share of the Registrant's Common Stock on the NASDAQ National
                  Market on January 6, 2006.
INTRODUCTORY
        STATEMENT
Pursuant
        to an Agreement and Plan of Merger, dated September 19, 2005 (the "
Merger
        Agreement
"),
        among
        Clinical Data, Inc. (the "
Registrant
"),
        Irides
        Acquisition Corporation ("
Irides
"),
        a
        wholly-owned subsidiary of the Registrant and Icoria, Inc. ("
Icoria
"),
        Irides
        was merged with and into Icoria with Icoria becoming a wholly-owned subsidiary
        of the Registrant (the "
Merger
").
        Under
        the terms of the Merger Agreement, each outstanding option previously granted
        by
        Icoria was assumed by the Registrant and became exercisable for that number
        of
        shares of the Registrant's common stock equal to the number of shares of Icoria
        common stock that were issuable upon exercise of the option immediately prior
        to
        the Merger multiplied by 0.01552 rounded down to the nearest whole share
        number,
        and the per share exercise price was adjusted to equal the exercise price
        for
        which the option was exercisable immediately prior to the Merger divided
        by
        0.01552, rounded up to the nearest whole cent.
PART
        I
INFORMATION
        REQUIRED IN THE SECTION 10(a) PROSPECTUS
The
        information required by Part I is included in the documents sent or given
        to
        participants in the plans covered by this registration statement pursuant
        to
        Rule 428(b)(1) of the Securities Act of 1933, as amended (the "
Securities
        Act
").
PART
        II
INFORMATION
        REQUIRED IN THE REGISTRATION STATEMENT
Item 3.
Incorporation
        of Documents By Reference.
The
        following documents filed by the Registrant with the Securities and Exchange
        Commission (the "
Commission
"),
        pursuant to the Securities Exchange Act of 1934, as amended (the "
Exchange
        Act
"),
        are
        incorporated by reference herein and shall be deemed as part
        hereof:
(a)
the
                  Registrant's Annual Report on Form 10-KSB for the fiscal year ended March
                  31, 2005, filed with the SEC on June 27,
                  2005;
(b)
the
                  Registrant's Quarterly Reports on Form 10-Q for the quarter ended June 30,
                  2005, filed with the SEC on August 15, 2005, and for the quarter
                  ended
                  September 30, 2005, filed with the SEC on November 14,
                  2005;
(c)
the
                  Registrant's Current Reports on Form 8-K, filed on April 21, 2005, June
                  21, 2005, June 24, 2005, July 11, 2005, August 2, 2005, September
                  20,
                  2005, September 22, 2005, September 28, 2005, October 11, 2005
                  (as amended
                  on November 9, 2005), October 21, 2005, November 1, 2005 (as to
                  Item 8.01
                  only), November 22, 2005 and December 27, 2005;
                  and
(d)
the
                  description of the Registrant's Common Stock, par value $0.01 per share,
                  contained in the Section entitled "Description of Clinical Data Capital
                  Stock - Clinical Data Common Stock", incorporated by reference from the
                  Registrant's Registration Statement on Form S-4, including the prospectus
                  contained therein, filed with the Commission on October 27, 2005,
                  including any amendment or report filed hereafter for the purpose
                  of
                  updating such description.
All
        documents subsequently filed by the Registrant pursuant to Sections 13(a),
        13(c), 14 and 15(d) of the Exchange Act, prior to the filing of a post-effective
        amendment which indicates that all securities offered have been sold or which
        deregisters all securities then remaining unsold, shall be deemed to be
        incorporated by reference herein and to be a part hereof from the date of
        filing
        of such documents.
Any
        statement contained in a document incorporated or deemed to be incorporated
        by
        reference herein shall be deemed to be modified or superseded for purposes
        of
        this Registration Statement to the extent that a statement contained herein
        or
        in any other subsequently filed document which also is or is deemed to be
        incorporated by reference herein modifies or supersedes such statement. Any
        such
        statement so modified or
-1-
superseded
        shall not be deemed, except as so modified or superseded, to constitute a
        part
        of this Registration Statement.
Item 4.
Description
        of Securities.
Not
        applicable.
Item 5.
Interests
        of Named Experts and Counsel.
Not
        applicable.
Item 6.
Indemnification
        of Directors and Officers.
The
        Registrant's certificate of incorporation provides that the Registrant shall, to
        the fullest extent permitted by Section 145 of the Delaware General Corporation
        Law, indemnify any and all directors and officers which it shall have the
        power
        to indemnify from and against any and all of the expenses, liabilities or
        other
        matters referred to in or covered by Section 145 of the Delaware General
        Corporation Law. The Registrant's certificate of incorporation also provides
        that such indemnification rights shall not be exclusive of any other rights
        to
        which those seeking indemnification may be entitled under any bylaw, agreement,
        vote of its stockholders or disinterested directors or otherwise. The
        Registrant's certificate of incorporation additionally provides that, to the
        fullest extent permitted by Delaware law, a director of the Registrant shall
        not
        be liable to the Registrant or its stockholders for monetary damages for
        breach
        of fiduciary duty as a director.
The
        Registrant's amended and restated bylaws provide that the Registrant shall, to
        the fullest extent authorized by the General Corporation Law of the state
        of
        Delaware, indemnify any person who was or is a party or is threatened to
        be made
        a party to or is otherwise involved in any threatened, pending or completed
        action, suit or proceeding, whether civil, criminal, administrative,
        investigative or otherwise, and whether by or in the right of the Registrant,
        its stockholders, a third party or otherwise, by reason of the fact that
        such
        person is or was a director or officer of the Registrant, or is or was serving
        at the request of the Registrant as a director, officer, employee or agent
        of
        another corporation, partnership, joint venture, trust or other enterprise,
        including, without limitation, a charity or a non-profit organization or
        person,
        against all expenses (including, but not limited to attorneys' fees), liability,
        loss, judgments, fines, excise taxes, penalties and amounts paid in settlement
        actually and reasonably incurred by such person in connection with such action,
        suit or proceeding, including expenses incurred in seeking indemnification.
        No
        indemnification is available with respect to: (i) indemnification of any
        improper personal benefit which a director or officer is determined to have
        received and of the expenses of defending against an improper personal benefit
        claim unless the director or officer is successful on the merits in said
        defense, and (ii) indemnification of present or former officers, directors,
        employees or agents of a constituent corporation absorbed in a merger or
        consolidation transaction with the Registrant with respect to their activities
        prior to said transaction, unless specifically authorized by the Registrant's
        board of directors or stockholders. The Registrant's bylaws also provide that
        such indemnification rights shall not be exclusive of other indemnification
        rights to which those seeking indemnification may be entitled by law or under
        any bylaw, agreement, vote of its stockholders or directors or
        otherwise.
The
        Registrant has entered into indemnification agreements with each of its current
        directors and officers, pursuant to which the Registrant agreed to indemnify
        each director and officer with respect to any expenses, judgments, fines,
        penalties, and amounts paid in settlement in connection with any claim, pending
        or completed action, suit or proceeding, or any inquiry or investigation,
        related to any actions taken by the director or officer related to their
        service
        to the Registrant as a director or officer.
The
        Registrant maintains insurance on behalf of any person who is a director
        or
        officer against any loss arising from any claim asserted against him or her
        and
        incurred by him or her in any such capacity, subject to certain
        exclusions.
Item 7.
Exemption
        from Registration Claimed.
Not
        applicable.
-2-
Item 8.
Exhibits.
The
        Exhibit Index immediately following the signature pages is incorporated by
        reference herein.
Item 9.
Undertakings.
(a)
The
        undersigned Registrant hereby undertakes:
(1)
To
        file,
        during any period in which offers or sales are being made, a post-effective
        amendment to this registration statement:
(i)
To
        include
        any prospectus required by Section 10(a)(3) of the Securities Act of
        1933;
(ii)
To
        reflect
        in the prospectus any facts or events arising after the effective date of
        this
        registration statement (or the most recent post-effective amendment thereof)
        which, individually or in the aggregate, represent a fundamental change in
        the
        information set forth in the registration statement. Notwithstanding the
        foregoing, any increase or decrease in volume of securities offered (if the
        total dollar value of securities offered would not exceed that which was
        registered) and any deviation from the low or high end of the estimated maximum
        offering range may be reflected in the form of prospectus filed with the
        Commission pursuant to Rule 424(b) if, in the aggregate, the changes in volume
        and price represent no more than a 20 percent change in the maximum aggregate
        offering price set forth in the "Calculation of Registration Fee" table in the
        registration statement;
(iii)
To
        include
        any material information with respect to the plan of distribution not previously
        disclosed in the registration statement or any material change to such
        information in the registration statement.
Provided
,
however
,
        that
Paragraphs
        (a)(1)(i) and (a)(1)(ii) of this section do not apply if the registration
        statement is on Form S-8, and the information required to be included in
        a
        post-effective amendment by those paragraphs is contained in reports filed
        with
        or furnished to the Commission by the Registrant pursuant to Section 13 or
        15(d)
        of the Securities Exchange Act of 1934 that are incorporated by reference
        in the
        registration statement.
(2)
That,
        for
        the purpose of determining any liability under the Securities Act of 1933,
        each
        such post-effective amendment shall be deemed to be a new registration statement
        relating to the securities offered therein, and the offering of such securities
        at that time shall be deemed to be the initial bona fide offering
        thereof.
(3)
To
        remove
        from registration by means of a post-effective amendment any of the securities
        being registered which remain unsold at the termination of the
        offering.
(b)
The
        undersigned Registrant hereby undertakes that, for purposes of determining
        any
        liability under the Securities Act of 1933, each filing of the Registrant's
        annual report pursuant to Section 13(a) or Section 15(d) of the Securities
        Exchange Act of 1934 (and, where applicable, each filing of an employee benefit
        plan's annual report pursuant to Section 15(d) of the Securities Exchange Act
        of
        1934) that is incorporated by reference in the registration statement shall
        be
        deemed to be a new registration statement relating to the securities offered
        therein, and the offering of such securities at that time shall be deemed
        to be
        the initial bona fide offering thereof.
(h)
Insofar
        as
        indemnification for liabilities arising under the Securities Act of 1933
        may be
        permitted to directors, officers and controlling persons of the Registrant
        pursuant to the foregoing provisions, or otherwise, the Registrant has been
        advised that in the opinion of the Securities and Exchange
-3-
Commission
        such indemnification is against public policy as expressed in the Securities
        Act
        of 1933 and is, therefore, unenforceable. In the event that a claim for
        indemnification against such liabilities (other than the payment by the
        Registrant of expenses incurred or paid by a director, officer or controlling
        person of the Registrant in the successful defense of any action, suit or
        proceeding) is asserted by such director, officer or controlling person in
        connection with the securities being registered, the Registrant will, unless
        in
        the opinion of its counsel the matter has been settled by controlling precedent,
        submit to a court of appropriate jurisdiction the question whether such
        indemnification by it is against public policy as expressed in the Act and
        will
        be governed by the final adjudication of such issue.
-4-
SIGNATURES
Pursuant
        to the requirements of the Securities Act of 1933, as amended, the Registrant
        certifies that it has reasonable grounds to believe that it meets all of
        the
        requirements for filing on Form S-8 and has duly caused this Registration
        Statement to be signed on its behalf by the undersigned, thereunto duly
        authorized, in the Town of Smithfield, State of Rhode Island, on January
        13,
        2006.
CLINICAL
                DATA,
                INC.
By:
/s/ Israel
                M.
                Stein
Israel
                  M. Stein, M.D.
President
                  and Chief Executive Officer
Principal
                  Executive Officer
By:
/s/
Mark
                  D. Shooman
Mark
                    D. Shooman
Senior
                      Vice President and Chief Financial Officer
Principal
                      Financial and Accounting
                      Officer
POWER
        OF ATTORNEY
Each
        person whose signature appears below hereby constitutes and appoints Israel
        M.
        Stein, M.D. and Caesar J. Belbel or either of them, his true and lawful
        attorneys and agent, with full power of substitution, and with power to act
        alone, to sign on behalf of the undersigned any amendment or amendments to
        this
        registration statement on Form S-8 (including pre- and post-effective
        amendments) and to perform any acts necessary to file such amendments, with
        exhibits thereto and other documents in connection therewith, and each of
        the
        undersigned does hereby ratify and confirm his signature as it may be signed
        by
        his said attorneys and agents to any and all such documents and all that
        said
        attorneys and agents, or their substitutes, shall do or cause to be done
        by
        virtue hereof.
Pursuant
        to the requirements of the Securities Act of 1933, this registration statement
        has been signed by the following persons in the capacities and as of the
        dates
        indicated.
Signature
Title
Date
/s/
Randal
                  J. Kirk
Randal
                  J. Kirk
Chairman
                  of the Board
January
                  13, 2006
/s/
Israel
                  M. Stein
Israel
                  M. Stein, M.D.
President,
                  Chief Executive Officer
and
                  Director (Principal Executive
Officer)
January
                  13, 2006
/s/
Larry
                  D. Horner
Larry
                  D. Horner
Director
January
                  13, 2006
/s/
Arthur
                  B. Malman
Arthur
                  B. Malman
Director
January
                  13, 2006
/s/
Burton
                  Sobel
Burton
                  Sobel
Director
January
                  13, 2006
/s/
J
oseph
K
lein
III
J
oseph
K
lein
III
Director
January
                  13, 2006
/s/
K
evin
R
akin
K
evin
R
akin
Director
January
                  13, 2006
/s/
G.
                  S
teven
                  Burrill
G.
                  S
teven
                  Burrill
Director
January
                  13, 2006
II-1
EXHIBIT
        INDEX
Exhibit
                  No.
Description
4.1
Certificate
                  of Incorporation. Filed as Exhibit 3.1 to Clinical Data's Registration
                  Statement on Form S-1 (File No. 2-82494) filed on March 17, 1983,
                  and
                  incorporated herein by reference.
4.2
Certificate
                  of Amendment of Certificate of Incorporation. Filed as Exhibit
                  3.1 to
                  Clinical Data's Quarterly Report on Form 10-QSB (File No. 000-12716) filed
                  on February 17, 2004, and incorporated herein by
                  reference.
4.3
Certificate
                  of Amendment to Certificate of Incorporation. Filed as Exhibit
                  3.1 to
                  Clinical Data's Current Report on Form 8-K (File No. 000-12716) filed on
                  October 11, 2005, and incorporated herein by reference.
4.4
Amended
                  and Restated Bylaws of Clinical Data. Filed as Exhibit 3.1 to Clinical
                  Data's Current Report on Form 8-K (File No. 000-12716) filed on June
                  24,
                  2005, and incorporated herein by reference.
4.5
Icoria,
                  Inc. 2003 Employee, Director and Consultant Stock Plan, as restated.
                  Filed
                  as Appendix B to the Definitive Proxy Statement on Schedule 14A
                  of
                  Paradigm Genetics, Inc. (File No. 000-30365) filed on March 31,
                  2004, and
                  incorporated herein by reference.
4.6
TissueInformatics.Inc
                  2001 Stock Option Plan. Filed as Exhibit 10.1 to the Form 10-Q
                  of Paradigm
                  Genetics, Inc. (File No. 000-30365) filed on May 17, 2004, and
                  incorporated herein by reference.
5.1
Opinion
                  of McDermott Will & Emery LLP as to the validity of the common stock
                  of Clinical Data being registered hereby, together with
                  consent.
23.1
Consent
                  of Deloitte & Touche LLP, Clinical Data's independent registered
                  public accounting firm.
23.2
Consent
                  of PricewaterhouseCoopers LLP, Icoria's independent registered public
                  accounting firm.
23.3
Consent
                  of PricewaterhouseCoopers LLP, Genaissance Pharmaceuticals, Inc.'s
                  independent registered public accounting firm.
23.4
Consent
                  of McDermott Will & Emery LLP (included in Exhibit
                  5.1).
24.1
Power
                  of Attorney (included in the signature page of this registration
                  statement).
II-2