<!--HTML document created with Certent Disclosure Management 22.2.0.1-->
<!--Created on: 6/10/2022 3:20:54 PM-->
<html>
	<head>
		<title>
			Cassava Sciences Form S-8 (2018 Plan Increase)
		</title>
	</head>
	<body><div style="margin-left:36pt;margin-right:36pt;">
		<p style="margin:0pt;line-height:100%;text-align:center;font-family:Calibri;font-size: 10pt">
			<font style="display: inline;font-family:Times New Roman;font-weight:bold;font-size:10pt;">As filed with the Securities and Exchange </font><font style="display: inline;font-family:Times New Roman;font-weight:bold;font-size:10pt;">Commission on </font><font style="display: inline;font-family:Times New Roman;font-weight:bold;font-size:10pt;">June 10, 2022</font>
		</p>
		<p style="margin:0pt;line-height:100%;text-align:center;font-family:Calibri;font-size: 12pt">
			<font style="display: inline;font-family:Times New Roman;font-size:12pt;">&#xFEFF;</font>
		</p>
		<p style="margin:0pt;line-height:100%;text-align:right;font-family:Calibri;font-size: 10pt">
			<font style="display: inline;font-family:Times New Roman;font-weight:bold;font-size:10pt;">Registration No.&nbsp;333</font><font style="display: inline;font-family:Times New Roman;font-weight:bold;font-size:10pt;">-</font><font style="display: inline;font-family:Times New Roman;font-weight:bold;font-size:10pt;"> &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</font>
		</p>
		<p style="margin:0pt;line-height:100%;font-family:Calibri;font-size: 10pt">
			<font style="display: inline;font-family:Times New Roman;font-size:10pt;">&nbsp;&nbsp;</font>
		</p>
		<p style="margin:0pt;line-height:100%;text-align:center;font-family:Calibri;font-size: 18pt">
			<font style="display: inline;font-family:Times New Roman;font-weight:bold;font-size:18pt;">UNITED STATES</font>
		</p>
		<p style="margin:0pt;line-height:100%;text-align:center;font-family:Calibri;font-size: 18pt">
			<font style="display: inline;font-family:Times New Roman;font-weight:bold;font-size:18pt;">SECURITIES AND EXCHANGE COMMISSION</font>
		</p>
		<p style="margin:0pt;line-height:100%;text-align:center;font-family:Calibri;font-size: 10pt">
			<font style="display: inline;font-family:Times New Roman;font-weight:bold;font-size:10pt;">Washington, D.C. 20549</font>
		</p>&nbsp;<hr style="border-bottom-style:solid;width:25%;height:.75pt; ;color:#000000" align="center"></hr>
		<p style="margin:0pt;line-height:100%;text-align:center;font-family:Calibri;font-size: 18pt">
			<font style="display: inline;font-family:Times New Roman;font-weight:bold;font-size:18pt;">FORM&nbsp;S-8</font>
		</p>
		<p style="margin:0pt;line-height:100%;text-align:center;font-family:Calibri;font-size: 10pt">
			<font style="display: inline;">&nbsp;</font>
		</p>
		<p style="margin:0pt;line-height:100%;text-align:center;font-family:Calibri;font-size: 12pt">
			<font style="display: inline;font-family:Times New Roman;font-weight:bold;font-size:12pt;">REGISTRATION STATEMENT UNDER THE SECURITIES ACT OF 1933</font>
		</p>
		<p style="margin:0pt;line-height:100%;text-align:center;font-family:Calibri;font-size: 10pt">
			<font style="display: inline;">&nbsp;</font>
		</p>
		<p style="margin:0pt;line-height:100%;text-align:center;font-family:Calibri;font-size: 18pt">
			<font style="display: inline;font-family:Times New Roman;font-weight:bold;font-size:18pt;">CASSAVA SCIENCES</font><font style="display: inline;font-family:Times New Roman;font-weight:bold;font-size:18pt;">,&nbsp;INC.</font>
		</p>
		<p style="margin:0pt;line-height:100%;text-align:center;font-family:Calibri;font-size: 10pt">
			<font style="display: inline;font-family:Times New Roman;font-size:10pt;">(Exact Name of Registrant as Specified in Its Charter)</font>
		</p>
		<p style="margin:0pt;line-height:100%;text-align:center;font-family:Calibri;font-size: 10pt">
			<font style="display: inline;">&nbsp;</font>
		</p>
		<div style="width:100%"><table cellpadding="0" cellspacing="0" align="center" style="border-collapse:collapse;width: 100.00%;margin-left:0pt;">
			<tr>
				<td valign="top" style="width:49.00%;padding:0pt;">
					<p style="margin:0pt;line-height:100%;text-align:center;font-family:Calibri;font-size: 10pt">
						<font style="display: inline;font-family:Times New Roman;font-weight:bold;font-size:10pt;">Delaware</font></p>
				</td>
				<td valign="bottom" style="width:02.00%;padding:0pt;">
					<p style="margin:0pt;line-height:100%;font-family:Calibri;font-size: 11pt">
						&nbsp;</p>
				</td>
				<td valign="top" style="width:49.00%;padding:0pt;">
					<p style="margin:0pt;line-height:100%;text-align:center;font-family:Calibri;font-size: 10pt">
						<font style="display: inline;font-family:Times New Roman;font-weight:bold;font-size:10pt;">9</font><font style="display: inline;font-family:Times New Roman;font-weight:bold;font-size:10pt;">1</font><font style="display: inline;font-family:Times New Roman;font-weight:bold;font-size:10pt;">-</font><font style="display: inline;font-family:Times New Roman;font-weight:bold;font-size:10pt;">1911336</font></p>
				</td>
			</tr>
			<tr>
				<td valign="top" style="width:49.00%;padding:0pt;">
					<p style="margin:0pt;line-height:100%;text-align:center;font-family:Calibri;font-size: 10pt">
						<font style="display: inline;font-family:Times New Roman;font-size:10pt;">(State or Other Jurisdiction of</font></p>
				</td>
				<td valign="bottom" style="width:02.00%;padding:0pt;">
					<p style="margin:0pt;line-height:100%;font-family:Calibri;font-size: 11pt">
						&nbsp;</p>
				</td>
				<td valign="top" style="width:49.00%;padding:0pt;">
					<p style="margin:0pt;line-height:100%;text-align:center;font-family:Calibri;font-size: 10pt">
						<font style="display: inline;font-family:Times New Roman;font-size:10pt;">(I.R.S. Employer</font></p>
				</td>
			</tr>
			<tr>
				<td valign="top" style="width:49.00%;padding:0pt;">
					<p style="margin:0pt;line-height:100%;text-align:center;font-family:Calibri;font-size: 10pt">
						<font style="display: inline;font-family:Times New Roman;font-size:10pt;">Incorporation or Organization)</font></p>
				</td>
				<td valign="bottom" style="width:02.00%;padding:0pt;">
					<p style="margin:0pt;line-height:100%;font-family:Calibri;font-size: 11pt">
						&nbsp;</p>
				</td>
				<td valign="top" style="width:49.00%;padding:0pt;">
					<p style="margin:0pt;line-height:100%;text-align:center;font-family:Calibri;font-size: 10pt">
						<font style="display: inline;font-family:Times New Roman;font-size:10pt;">Identification </font><font style="display: inline;font-family:Times New Roman;font-size:10pt;">No.</font><font style="display: inline;font-family:Times New Roman;font-size:10pt;">)</font></p>
				</td>
			</tr>
		</table></div>
		<p style="margin:0pt;line-height:100%;font-family:Calibri;font-size: 10pt">
			<font style="display: inline;">&nbsp;</font>
		</p>
		<p style="margin:0pt;line-height:100%;text-align:center;font-family:Calibri;font-size: 10pt">
			<font style="display: inline;font-family:Times New Roman;font-weight:bold;font-size:10pt;">7801 N Capital of Texas Highway, Suite 260</font>
		</p>
		<p style="margin:0pt;line-height:100%;text-align:center;font-family:Calibri;font-size: 10pt">
			<font style="display: inline;font-family:Times New Roman;font-weight:bold;font-size:10pt;">Austin, Texas 78731</font>
		</p>
		<p style="margin:0pt;line-height:100%;text-align:center;font-family:Calibri;font-size: 10pt">
			<font style="display: inline;font-family:Times New Roman;font-size:10pt;">(Address of Principal Executive Offices) (Zip Code)</font>
		</p>
		<p style="margin:0pt;line-height:100%;text-align:center;font-family:Calibri;font-size: 10pt">
			<font style="display: inline;">&nbsp;</font>
		</p>
		<p style="margin:0pt;line-height:100%;text-align:center;font-family:Calibri;font-size: 10pt">
			<font style="display: inline;font-family:Times New Roman;font-weight:bold;font-size:10pt;">2018 Omnibus Incentive Plan</font>
		</p>
		<p style="margin:0pt;line-height:100%;text-align:center;font-family:Calibri;font-size: 10pt">
			<font style="display: inline;font-family:Times New Roman;font-size:10pt;">(Full Title of the Plan)</font>
		</p>
		<p style="margin:0pt;line-height:100%;text-align:center;font-family:Calibri;font-size: 10pt">
			<font style="display: inline;">&nbsp;</font>
		</p>
		<p style="margin:0pt;line-height:100%;text-align:center;font-family:Calibri;font-size: 10pt">
			<font style="display: inline;font-family:Times New Roman;font-weight:bold;font-size:10pt;">Remi Barbier</font>
		</p>
		<p style="margin:0pt;line-height:100%;text-align:center;font-family:Calibri;font-size: 10pt">
			<font style="display: inline;font-family:Times New Roman;font-weight:bold;font-size:10pt;">Chairman of the Board of Directors, </font><font style="display: inline;font-family:Times New Roman;font-weight:bold;font-size:10pt;">President and Chief Executive Officer</font>
		</p>
		<p style="margin:0pt;line-height:100%;text-align:center;font-family:Calibri;font-size: 10pt">
			<font style="display: inline;font-family:Times New Roman;font-weight:bold;font-size:10pt;">Cassava Sciences</font><font style="display: inline;font-family:Times New Roman;font-weight:bold;font-size:10pt;">, Inc.</font>
		</p>
		<p style="margin:0pt;line-height:100%;text-align:center;font-family:Calibri;font-size: 10pt">
			<font style="display: inline;font-family:Times New Roman;font-weight:bold;font-size:10pt;">7801 N Capital of Texas Highway, Suite 260</font>
		</p>
		<p style="margin:0pt;line-height:100%;text-align:center;font-family:Calibri;font-size: 10pt">
			<font style="display: inline;font-family:Times New Roman;font-weight:bold;font-size:10pt;">Austin, Texas 78731</font>
		</p>
		<p style="margin:0pt;line-height:100%;text-align:center;font-family:Calibri;font-size: 10pt">
			<font style="display: inline;font-family:Times New Roman;font-size:10pt;">(Name and Address of Agent for Service)</font>
		</p>
		<p style="margin:0pt;line-height:100%;text-align:center;font-family:Calibri;font-size: 10pt">
			<font style="display: inline;">&nbsp;</font>
		</p>
		<p style="margin:0pt;line-height:100%;text-align:center;font-family:Calibri;font-size: 10pt">
			<font style="display: inline;font-family:Times New Roman;font-weight:bold;font-size:10pt;">(512) 501-2444</font>
		</p>
		<p style="margin:0pt;line-height:100%;text-align:center;font-family:Calibri;font-size: 10pt">
			<font style="display: inline;font-family:Times New Roman;font-size:10pt;">(Telephone Number,&nbsp;Including Area Code, of Agent for Service)</font>
		</p>
		<p style="margin:0pt;line-height:100%;text-align:center;font-family:Calibri;font-size: 10pt">
			<font style="display: inline;">&nbsp;</font>
		</p>
		<p style="margin:0pt;line-height:100%;text-align:center;font-family:Calibri;font-size: 10pt">
			<font style="display: inline;">&nbsp;</font>
		</p>
		<p style="margin:0pt;line-height:100%;font-family:Calibri;font-size: 10pt">
			<font style="display: inline;font-family:Times New Roman;font-size:10pt;">Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer</font><font style="display: inline;font-family:Times New Roman;font-size:10pt;">,</font><font style="display: inline;font-family:Times New Roman;font-size:10pt;"> a smaller reporting company</font><font style="display: inline;font-family:Times New Roman;font-size:10pt;"> or an </font><font style="display: inline;font-family:Times New Roman;font-size:10pt;">emerging growth company</font><font style="display: inline;font-family:Times New Roman;font-size:10pt;">.&nbsp; See the definitions of &#x201C;large accelerated filer&#x201D;, &#x201C;accelerated filer</font><font style="display: inline;font-family:Times New Roman;font-size:10pt;">,</font><font style="display: inline;font-family:Times New Roman;font-size:10pt;">&#x201D; &#x201C;smaller reporting company&#x201D; </font><font style="display: inline;font-family:Times New Roman;font-size:10pt;">and </font><font style="display: inline;font-family:Times New Roman;font-size:10pt;">&#x201C;</font><font style="display: inline;font-family:Times New Roman;font-size:10pt;">emerging growth company</font><font style="display: inline;font-family:Times New Roman;font-size:10pt;">&#x201D;</font><font style="display: inline;font-family:Times New Roman;font-size:10pt;">&nbsp;</font><font style="display: inline;font-family:Times New Roman;font-size:10pt;">in Rule&nbsp;12b-2 of the Exchange Act.</font>
		</p>
		<p style="margin:0pt;line-height:100%;font-family:Calibri;font-size: 10pt">
			<font style="display: inline;">&nbsp;</font>
		</p>
		<div style="width:100%"><table cellpadding="0" cellspacing="0" align="center" style="border-collapse:collapse;width: 100.98%;margin-left:0pt;">
			<tr>
				<td valign="top" style="width:02.86%;height:13.50pt;padding:0pt;">
					<p style="margin:0pt;line-height:100%;font-family:Calibri;font-size: 10pt">
						<font style="display: inline;font-family:Times New Roman;font-size:10pt;">&#xFEFF;</font></p>
				</td>
				<td valign="top" style="width:26.86%;height:13.50pt;padding:0pt;">
					<p style="margin:0pt;line-height:100%;font-family:Calibri;font-size: 10pt">
						<font style="display: inline;font-family:Times New Roman;font-size:10pt;">Large accelerated filer </font></p>
				</td>
				<td valign="top" style="width:33.54%;height:13.50pt;padding:0pt;">
					<p style="margin:0pt;line-height:100%;font-family:Calibri;font-size: 10pt">
						<font style="display: inline;font-size:10pt;">&#x2612;</font></p>
				</td>
				<td valign="bottom" style="width:02.86%;height:13.50pt;padding:0pt;">
					<p style="margin:0pt;line-height:100%;font-family:Calibri;overflow: hidden;font-size:0pt;">
						&nbsp;</p>
				</td>
				<td valign="top" style="width:28.34%;height:13.50pt;padding:0pt;">
					<p style="margin:0pt;line-height:100%;font-family:Calibri;font-size: 10pt">
						<font style="display: inline;font-family:Times New Roman;font-size:10pt;">Accelerated filer </font></p>
				</td>
				<td valign="top" style="width:05.54%;height:13.50pt;padding:0pt;">
					<p style="margin:0pt;line-height:100%;font-family:Calibri;font-size: 10pt">
						<a name="OLE_LINK2"></a><font style="display: inline;font-size:10pt;">&#x2610;</font></p>
				</td>
			</tr>
			<tr>
				<td valign="top" style="width:02.86%;padding:0pt;">
					<p style="margin:0pt;line-height:100%;font-family:Calibri;font-size: 10pt">
						<font style="display: inline;font-family:Times New Roman;font-size:10pt;">&#xFEFF;</font></p>
				</td>
				<td valign="top" style="width:26.86%;padding:0pt;">
					<p style="margin:0pt;line-height:100%;font-family:Calibri;font-size: 10pt">
						<font style="display: inline;font-family:Times New Roman;font-size:10pt;">Non-accelerated filer </font></p>
				</td>
				<td valign="top" style="width:33.54%;padding:0pt;">
					<p style="margin:0pt;line-height:100%;font-family:Calibri;font-size: 10pt">
						<font style="display: inline;font-size:10pt;">&#x2610;</font><font style="display: inline;font-family:Times New Roman;font-size:10pt;">&nbsp;</font></p>
				</td>
				<td valign="bottom" style="width:02.86%;padding:0pt;">
					<p style="margin:0pt;line-height:100%;font-family:Calibri;font-size: 11pt">
						&nbsp;</p>
				</td>
				<td valign="top" style="width:28.34%;padding:0pt;">
					<p style="margin:0pt;line-height:100%;font-family:Calibri;font-size: 10pt">
						<font style="display: inline;font-family:Times New Roman;font-size:10pt;">Smaller reporting company </font></p>
				</td>
				<td valign="top" style="width:05.54%;padding:0pt;">
					<p style="margin:0pt;line-height:100%;font-family:Calibri;font-size: 10pt">
						<font style="display: inline;font-size:10pt;">&#x2610;</font></p>
				</td>
			</tr>
			<tr>
				<td valign="bottom" style="width:02.86%;padding:0pt;">
					<p style="margin:0pt;line-height:100%;font-family:Calibri;font-size: 12pt">
						<font style="display: inline;font-family:Times New Roman;font-size:12pt;">&#xFEFF;</font></p>
				</td>
				<td valign="top" style="width:26.86%;padding:0pt;">
					<p style="margin:0pt;line-height:100%;font-family:Calibri;font-size: 10pt">
						<font style="display: inline;font-family:Times New Roman;font-size:10pt;">Emerging growth </font><font style="display: inline;font-family:Times New Roman;font-size:10pt;">company </font></p>
				</td>
				<td colspan="4" valign="top" style="width:70.28%;padding:0pt;">
					<p style="margin:0pt;line-height:100%;font-family:Calibri;font-size: 10pt">
						<a name="OLE_LINK1"></a><font style="display: inline;font-size:10pt;">&#x2610;</font></p>
				</td>
			</tr>
		</table></div>
		<p style="margin:0pt;line-height:100%;font-family:Calibri;font-size: 10pt">
			<font style="display: inline;font-family:Times New Roman;font-size:10pt;">&#xFEFF;</font>
		</p>
		<p style="margin:0pt;line-height:100%;font-family:Calibri;font-size: 10pt">
			<font style="display: inline;font-family:Times New Roman;font-size:10pt;">If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 7(a)(2)(B) of the Securities Act.</font><font style="display: inline;font-family:Times New Roman;font-size:10pt;">&nbsp;</font><font style="display: inline;font-size:10pt;">&#x2610;</font>
		</p></div><div style="margin-left:72pt;margin-right:72pt;">
		<p style="margin:0pt;line-height:100%;text-align:center;font-family:Calibri;font-size: 10pt">

		</p>
		<p><font size="1"> </font></p><hr size="3" style="color:#999999" width="100%" align="center"></hr><p style="page-break-after:always">&nbsp;</p>
		<p style="margin:0pt;line-height:100%;text-align:center;font-family:Calibri;;font-size: 10pt"><font style="display: inline;font-family:Times New Roman;font-weight:bold;font-size:10pt;">EXPLANATORY NOTE</font>
		</p>
		<p style="margin:0pt;line-height:100%;text-align:center;font-family:Calibri;font-size: 10pt">
			<font style="display: inline;font-family:Times New Roman;font-weight:bold;font-size:10pt;">&#xFEFF;</font>
		</p>
		<p style="margin:0pt;line-height:100%;text-indent:36pt;font-family:Calibri;font-size: 10pt">
			<font style="display: inline;font-family:Times New Roman;font-size:10pt;">A Registration Statement on Form S-8 was filed with the Securities and Exchange Commission (the &#x201C;Commission&#x201D;) on June 19, 2018 (File No. 333-225708) covering the registration of 1,000,000 shares of Common Stock, par value $0.001 per share, of Cassava Sciences, Inc. (the </font><font style="display: inline;font-family:Times New Roman;font-size:10pt;">&#x201C;Registrant</font><font style="display: inline;font-family:Times New Roman;font-size:10pt;">&#x201D;) </font><font style="display: inline;font-family:Times New Roman;font-size:10pt;">authorized for issuance </font><font style="display: inline;font-family:Times New Roman;font-size:10pt;">under the 2018 Omnibus Incentive Plan (the &#x201C;Plan&#x201D;). </font><font style="display: inline;font-family:Times New Roman;font-size:10pt;">T</font><font style="display: inline;font-family:Times New Roman;font-size:10pt;">his Registration Statement on Form S-8 is being filed to register an additional 4,000,000 shares of Common Stock </font><font style="display: inline;font-family:Times New Roman;color:#000000;font-size:10pt;">that were added to the shares authorized for issuance under the Plan pursuant to Amendment No. 1 to the Plan, which was approved by the Registrant&#x2019;s stockholders on May 5, 2022, the date of the Registrant&#x2019;s 2022 Annual Meeting</font><font style="display: inline;font-family:Times New Roman;font-size:10pt;">. &nbsp;</font>
		</p>
		<p style="margin:0pt;line-height:100%;text-align:center;font-family:Calibri;font-size: 10pt">
			<font style="display: inline;font-family:Times New Roman;font-weight:bold;font-size:10pt;">&#xFEFF;</font>
		</p>
		<p style="margin:0pt;line-height:100%;text-align:center;font-family:Calibri;font-size: 10pt">
			<font style="display: inline;font-family:Times New Roman;font-weight:bold;font-size:10pt;">PART I </font>
		</p>
		<p style="margin:9pt 0pt 0pt;line-height:100%;text-align:center;font-family:Calibri;font-size: 10pt">
			<font style="display: inline;font-family:Times New Roman;font-weight:bold;font-size:10pt;">INFORMATION REQUIRED IN THE SECTION 10(A) PROSPECTUS</font>
		</p>
		<p style="margin:9pt 0pt 0pt;line-height:100%;text-indent:36pt;font-family:Calibri;font-size: 10pt">
			<font style="display: inline;font-family:Times New Roman;font-size:10pt;">The documents containing the information specified in this Part I will be delivered to the participants in the </font><font style="display: inline;font-family:Times New Roman;font-size:10pt;">Plan</font><font style="display: inline;font-family:Times New Roman;font-size:10pt;"> as required by Rule 428(b)(1) of the Securities Act. Such documents are not required to be filed with the Commission as part of this Registration Statement. </font>
		</p>
		<p style="margin:0pt;line-height:100%;text-align:center;font-family:Calibri;font-size: 10pt">
			<font style="display: inline;font-family:Times New Roman;font-weight:bold;font-size:10pt;">&#xFEFF;</font>
		</p>
		<p style="margin:0pt;line-height:100%;text-align:center;font-family:Calibri;font-size: 10pt">
			<font style="display: inline;font-family:Times New Roman;font-weight:bold;font-size:10pt;">PART&nbsp;II</font><a name="Partii_034343"></a>
		</p>
		<p style="margin:0pt;line-height:100%;text-align:center;font-family:Calibri;font-size: 10pt">
			<font style="display: inline;">&nbsp;</font>
		</p>
		<p style="margin:0pt;line-height:100%;text-align:center;font-family:Calibri;font-size: 10pt">
			<font style="display: inline;font-family:Times New Roman;font-weight:bold;font-size:10pt;">INFORMATION REQUIRED IN THE REGISTRATION STATEMENT</font>
		</p>
		<p style="margin:0pt;line-height:100%;text-align:center;font-family:Calibri;font-size: 10pt">
			<font style="display: inline;">&nbsp;</font>
		</p>
		<p style="margin:0pt;line-height:100%;font-family:Calibri;font-size: 10pt">
			<font style="display: inline;font-family:Times New Roman;font-weight:bold;font-size:10pt;">Item 3.&nbsp;&nbsp;&nbsp; </font><font style="display: inline;font-family:Times New Roman;font-weight:bold;font-size:10pt;text-decoration:underline;">Incorporation of Documents by Reference</font><font style="display: inline;font-family:Times New Roman;font-weight:bold;font-size:10pt;">.</font><a name="Item3_IncorporationOfDocumentsByR_034347"></a>
		</p>
		<p style="margin:0pt;line-height:100%;font-family:Calibri;font-size: 10pt">
			<font style="display: inline;">&nbsp;</font>
		</p>
		<p style="margin:0pt;line-height:100%;text-indent:36pt;font-family:Calibri;font-size: 10pt">
			<font style="display: inline;font-family:Times New Roman;font-size:10pt;">The following documents, which have been filed by the Registrant with the Commission, are hereby incorporated by reference in this Registration Statement</font><font style="display: inline;font-family:Times New Roman;font-size:10pt;">:</font>
		</p>
		<p style="margin:0pt;line-height:100%;font-family:Calibri;font-size: 10pt">
			<font style="display: inline;">&nbsp;</font>
		</p>
		<p style="margin:0pt 0pt 0pt 36pt;line-height:100%;text-indent: -18pt;font-family:Calibri;font-size: 10pt">
			<font style="display: inline;font-family:Times New Roman;font-size:10pt;">(a)</font><font style="display: inline;font-family:Times New Roman;font-size:10pt;"> &nbsp; &nbsp;</font><font style="display: inline;font-family:Times New Roman;font-size:10pt;">The Registrant&#x2019;s Annual Report on Form&nbsp;10-K </font><font style="display: inline;font-family:Times New Roman;font-size:10pt;">(</font><font style="display: inline;font-family:Times New Roman;font-size:10pt;">the &#x201C;Annual Report&#x201D;</font><font style="display: inline;font-family:Times New Roman;font-size:10pt;">)</font><font style="display: inline;font-family:Times New Roman;font-size:10pt;">&nbsp;</font><font style="display: inline;font-family:Times New Roman;font-size:10pt;">for the fis</font><font style="display: inline;font-family:Times New Roman;font-size:10pt;">cal year ended </font><font style="display: inline;font-family:Times New Roman;font-size:10pt;">December</font><font style="display: inline;font-family:Times New Roman;font-size:10pt;">&nbsp;31, </font><font style="display: inline;font-family:Times New Roman;font-size:10pt;">20</font><font style="display: inline;font-family:Times New Roman;font-size:10pt;">2</font><font style="display: inline;font-family:Times New Roman;font-size:10pt;">1</font><font style="display: inline;font-family:Times New Roman;font-size:10pt;">, filed with the </font><font style="display: inline;font-family:Times New Roman;font-size:10pt;">Commi</font><font style="display: inline;font-family:Times New Roman;font-size:10pt;">s</font><font style="display: inline;font-family:Times New Roman;font-size:10pt;">sion</font><font style="display: inline;font-family:Times New Roman;font-size:10pt;"> on </font><font style="display: inline;font-family:Times New Roman;font-size:10pt;">March </font><font style="display: inline;font-family:Times New Roman;font-size:10pt;">1</font><font style="display: inline;font-family:Times New Roman;font-size:10pt;">, &nbsp;</font><font style="display: inline;font-family:Times New Roman;font-size:10pt;">20</font><font style="display: inline;font-family:Times New Roman;font-size:10pt;">2</font><font style="display: inline;font-family:Times New Roman;font-size:10pt;">2</font><font style="display: inline;font-family:Times New Roman;font-size:10pt;">&nbsp;</font><font style="display: inline;font-family:Times New Roman;font-size:10pt;">;</font><font style="display: inline;font-family:Times New Roman;font-size:10pt;">&nbsp;</font>
		</p>
		<p style="margin:0pt 0pt 0pt 36pt;line-height:100%;text-indent: -18pt;font-family:Calibri;font-size: 10pt">
			<font style="display: inline;">&nbsp;</font>
		</p>
		<p style="margin:0pt 0pt 0pt 36pt;line-height:100%;text-indent: -18pt;font-family:Calibri;font-size: 10pt">
			<font style="display: inline;font-family:Times New Roman;font-size:10pt;">(b)</font><font style="display: inline;font-family:Times New Roman;font-size:10pt;"> &nbsp; &nbsp;</font><font style="display: inline;font-family:Times New Roman;font-size:10pt;">All other reports filed pursuant to Section&nbsp;13(a)&nbsp;or 15(d)&nbsp;of the Securities</font><font style="display: inline;font-family:Times New Roman;font-size:10pt;"> Exchange Act of 1934, as amended (the &#x201C;Exchange Act&#x201D;), since the end of the fiscal year covered by the </font><font style="display: inline;font-family:Times New Roman;font-size:10pt;">Annual Report </font><font style="display: inline;font-family:Times New Roman;font-size:10pt;">referred to in (a)&nbsp;above; and</font>
		</p>
		<p style="margin:0pt 0pt 0pt 36pt;line-height:100%;text-indent: -18pt;font-family:Calibri;font-size: 10pt">
			<font style="display: inline;">&nbsp;</font>
		</p>
		<p style="margin:0pt 0pt 0pt 36pt;line-height:100%;text-indent: -18pt;font-family:Calibri;font-size: 10pt">
			<font style="display: inline;font-family:Times New Roman;font-size:10pt;">(c)</font><font style="display: inline;font-family:Times New Roman;font-size:10pt;"> &nbsp; &nbsp;</font><font style="display: inline;font-family:Times New Roman;font-size:10pt;">The </font><font style="display: inline;font-family:Times New Roman;font-size:10pt;">description of Common Stock contained in</font><font style="display: inline;font-family:Times New Roman;font-size:10pt;">&nbsp;</font><font style="display: inline;font-family:Times New Roman;font-size:10pt;">Exhibit 4.2</font><font style="display: inline;font-family:Times New Roman;font-size:10pt;"> of</font><font style="display: inline;font-family:Times New Roman;font-size:10pt;"> the </font><font style="display: inline;font-family:Times New Roman;font-size:10pt;">Registrant&#x2019;s </font><font style="display: inline;font-family:Times New Roman;font-size:10pt;">Annual Report for the fiscal year ended December 31, 2019</font><font style="display: inline;font-family:Times New Roman;font-size:10pt;">, filed with the </font><font style="display: inline;font-family:Times New Roman;font-size:10pt;">Commission</font><font style="display: inline;font-family:Times New Roman;font-size:10pt;"> on </font><font style="display: inline;font-family:Times New Roman;font-size:10pt;">March</font><font style="display: inline;">&nbsp;</font><font style="display: inline;font-family:Times New Roman;font-size:10pt;">26</font><font style="display: inline;font-family:Times New Roman;font-size:10pt;">, &nbsp;</font><font style="display: inline;font-family:Times New Roman;font-size:10pt;">20</font><font style="display: inline;font-family:Times New Roman;font-size:10pt;">2</font><font style="display: inline;font-family:Times New Roman;font-size:10pt;">0</font><font style="display: inline;font-family:Times New Roman;font-size:10pt;">.&nbsp;</font>
		</p>
		<p style="margin:9pt 0pt 0pt;line-height:100%;text-indent:36pt;font-family:Calibri;font-size: 10pt">
			<font style="display: inline;font-family:Times New Roman;font-size:10pt;">All documents subsequently filed by the Registrant pursuant to Sections 13(a), 13(c), 14 and 15(d) of the Exchange Act, prior to the filing of a post-effective amendment, which indicates that all securities offered hereby have been sold or which deregisters all securities then remaining unsold, shall be deemed to be incorporated by reference herein and to be a part hereof from the date of the filing of such documents, except as to specific sections of such statements as set forth therein.</font>
		</p>
		<p style="margin:9pt 0pt 0pt;line-height:100%;text-indent:36pt;font-family:Calibri;font-size: 10pt">
			<font style="display: inline;font-family:Times New Roman;font-size:10pt;">Unless expressly incorporated into this Registration Statement, a report furnished on Form 8-K prior or subsequent to the date hereof shall not be incorporated by reference into this Registration Statement, except as to specific sections of such statements as set forth therein. Any statement contained in a document incorporated or deemed to be incorporated by reference herein shall be deemed to be modified or superseded for purposes of this Registration Statement to the extent that a statement contained in any subsequently filed document, which also is deemed to be incorporated by reference herein, modifies or supersedes such statement.</font>
		</p>
		<p style="margin:0pt;line-height:100%;font-family:Calibri;font-size: 10pt">
			<font style="display: inline;font-family:Times New Roman;font-weight:bold;font-size:10pt;">&#xFEFF;</font>
		</p>
		<p style="margin:0pt;line-height:100%;font-family:Calibri;font-size: 10pt">
			<font style="display: inline;font-family:Times New Roman;font-weight:bold;font-size:10pt;">Item 4.&nbsp;&nbsp;&nbsp; </font><font style="display: inline;font-family:Times New Roman;font-weight:bold;font-size:10pt;text-decoration:underline;">Description of Securities</font><font style="display: inline;font-family:Times New Roman;font-weight:bold;font-size:10pt;">.</font><a name="Item4_DescriptionOfSecurities__035836"></a>
		</p>
		<p style="margin:0pt;line-height:100%;font-family:Calibri;font-size: 10pt">
			<font style="display: inline;">&nbsp;</font>
		</p>
		<p style="margin:0pt;line-height:100%;text-indent:36pt;font-family:Calibri;font-size: 10pt">
			<font style="display: inline;font-family:Times New Roman;font-size:10pt;">Not applicable.</font>
		</p>
		<p style="margin:0pt;line-height:100%;font-family:Calibri;font-size: 10pt">
			<font style="display: inline;">&nbsp;</font>
		</p>
		<p style="margin:0pt;line-height:100%;font-family:Calibri;font-size: 10pt">
			<font style="display: inline;font-family:Times New Roman;font-weight:bold;font-size:10pt;">Item 5.&nbsp;&nbsp;&nbsp; </font><font style="display: inline;font-family:Times New Roman;font-weight:bold;font-size:10pt;text-decoration:underline;">Interests of Named Experts and Counsel</font><font style="display: inline;font-family:Times New Roman;font-weight:bold;font-size:10pt;">.</font><a name="Item5_InterestsOfNamedExpertsAndC_035842"></a>
		</p>
		<p style="margin:0pt;line-height:100%;font-family:Calibri;font-size: 10pt">
			<font style="display: inline;">&nbsp;</font>
		</p>
		<p style="margin:0pt;line-height:100%;text-indent:36pt;font-family:Calibri;font-size: 10pt">
			<font style="display: inline;font-family:Times New Roman;font-size:10pt;">Not applicable.</font>
		</p>
		<p style="margin:0pt;line-height:100%;font-family:Calibri;font-size: 10pt">
			<font style="display: inline;">&nbsp;</font>
		</p>
		<p style="margin:0pt;line-height:100%;font-family:Calibri;font-size: 10pt">
			<font style="display: inline;font-family:Times New Roman;font-weight:bold;font-size:10pt;">Item 6.&nbsp;&nbsp;&nbsp; </font><font style="display: inline;font-family:Times New Roman;font-weight:bold;font-size:10pt;text-decoration:underline;">Indemnification of Directors and Officers</font><font style="display: inline;font-family:Times New Roman;font-weight:bold;font-size:10pt;">.</font><a name="Item6_IndemnificationOfDirectorsA_035846"></a>
		</p>
		<p style="margin:9pt 0pt 0pt;line-height:100%;text-indent:36pt;font-family:Calibri;font-size: 10pt">
			<font style="display: inline;font-family:Times New Roman;font-size:10pt;">The Delaware General Corporation Law (the &#x201C;DGCL&#x201D;) authorizes corporations to limit or eliminate the personal liability of directors to corporations and their stockholders for monetary damages for breaches of directors&#x2019; fiduciary duties as directors, and our amended and restated certificate of incorporation includes such an exculpation provision. Under the provisions of our amended and restated certificate of incorporation and bylaws, each person </font>
		</p>
		<p><font size="1"> </font></p><hr size="3" style="color:#999999" width="100%" align="center"></hr><p style="page-break-after:always">&nbsp;</p>
		<p style="margin:9pt 0pt 0pt;line-height:100%;font-family:Calibri;font-size: 10pt"><font style="display: inline;font-family:Times New Roman;font-size:10pt;">who is or was one of our directors or officers shall be indemnified by us as of right to the full extent permitted by the DGCL.</font>
		</p>
		<p style="margin:9pt 0pt 0pt;line-height:100%;text-indent:36pt;font-family:Calibri;font-size: 10pt">
			<font style="display: inline;font-family:Times New Roman;font-size:10pt;">Under the DGCL, to the extent that a person is successful on the merits in defense of a suit or proceeding brought against him or her because that person is or was one of our directors or officers, he or she shall be indemnified against expenses (including attorneys&#x2019; fees) actually and reasonably incurred in connection with such action. If unsuccessful in defense of a third-party civil suit or a criminal suit, or if such a suit is settled, that person shall be indemnified against both (i) expenses, including attorneys&#x2019; fees, and (ii) judgments, fines and amounts paid in settlement if he or she acted in good faith and in a manner he or she reasonably believed to be in, or not opposed to, our best interests and, with respect to any criminal action, had no reasonable cause to believe his or her conduct was unlawful. If unsuccessful in defense of a suit brought by or in our right, or if such suit is settled, that person shall be indemnified only against expenses, including attorneys&#x2019; fees, incurred in the defense or settlement of the suit if he or she acted in good faith and in a manner he or she&nbsp;&nbsp;reasonably believed to be in, or not opposed to, our best interests, except that </font><font style="display: inline;font-family:Times New Roman;font-size:10pt;">no indemnification shall be made in respect of any claim, issue or matter as to which such person shall have been adjudged to be liable to the corporation unless and only to the extent that the Court of Chancery or the court in which such action or suit was brought shall determine upon application that, despite the adjudication of liability but in view of all circumstances of the case, such person is fairly and reasonably entitled to indemnity for such expenses which the Court of Chancery or such other court shall deem proper</font><font style="display: inline;font-family:Times New Roman;font-size:10pt;">.</font>
		</p>
		<p style="margin:9pt 0pt 0pt;line-height:100%;text-indent:36pt;font-family:Calibri;font-size: 10pt">
			<font style="display: inline;font-family:Times New Roman;font-size:10pt;">Under our amended and restated certificate of incorporation and bylaws, the right to indemnification includes the right to be paid by us the expenses incurred in defending any action, suit or proceeding in advance of its final disposition, subject to the receipt by us of undertakings as may be legally defined. In any action by an indemnitee to enforce a right to indemnification or by us to recover advances made, the burden of proving that the indemnitee is not entitled to be indemnified is placed on us.</font>
		</p>
		<p style="margin:9pt 0pt 0pt;line-height:100%;text-indent:36pt;font-family:Calibri;font-size: 10pt">
			<font style="display: inline;font-family:Times New Roman;font-size:10pt;">The </font><font style="display: inline;font-family:Times New Roman;font-size:10pt;">Registrant</font><font style="display: inline;font-family:Times New Roman;font-size:10pt;"> has entered into indemnification agreements with its current directors and officers. The indemnification agreements supplement the indemnification provisions applicable under our amended and restated certificate of incorporation and bylaws, and the DGCL.</font>
		</p>
		<p style="margin:9pt 0pt 0pt;line-height:100%;text-indent:36pt;font-family:Calibri;font-size: 10pt">
			<font style="display: inline;font-family:Times New Roman;font-size:10pt;">Among the terms and conditions of the indemnification agreements are provisions providing for director and officer indemnitees to be indemnified in the context of certain third-party proceedings and proceedings by or in the right of the </font><font style="display: inline;font-family:Times New Roman;font-size:10pt;">Registrant</font><font style="display: inline;font-family:Times New Roman;font-size:10pt;">. The agreements also provide for, under certain circumstances, indemnification against certain expenses to the extent an indemnitee is wholly or partly successful in a proceeding, and to the extent an indemnitee is a witness or otherwise asked to participate in a proceeding to which the indemnitee is not a party. Also, under certain conditions, the indemnification agreements provide for the advancement of certain expenses from the </font><font style="display: inline;font-family:Times New Roman;font-size:10pt;">Registrant</font><font style="display: inline;font-family:Times New Roman;font-size:10pt;"> to an indemnitee.</font>
		</p>
		<p style="margin:9pt 0pt 0pt;line-height:100%;text-indent:36pt;font-family:Calibri;font-size: 10pt">
			<font style="display: inline;font-family:Times New Roman;font-size:10pt;">We maintain liability insurance for our directors and officers to provide protection where we cannot legally indemnify a director or officer and where a claim arises under the Employee Retirement Income Security Act of 1974 against a director or officer based on an alleged breach of fiduciary duty or other wrongful act and directors&#x2019; and officers&#x2019; liability insurance for our directors and officers.</font>
		</p>
		<p style="margin:9pt 0pt 0pt;line-height:100%;text-indent:36pt;font-family:Calibri;font-size: 10pt">
			<font style="display: inline;font-family:Times New Roman;font-size:10pt;">The foregoing is only a general summary of certain aspects of Delaware law and our amended and restated certificate of incorporation and bylaws dealing with indemnification of directors and officers and does not purport to be complete. It is qualified in its entirety by reference to the detailed provisions of those sections of the DGCL referenced above and our amended and restated certificate of incorporation and bylaws.</font>
		</p>
		<p style="margin:0pt;line-height:100%;font-family:Calibri;font-size: 10pt">
			<font style="display: inline;">&nbsp;</font>
		</p>
		<p style="margin:0pt;line-height:100%;font-family:Calibri;font-size: 10pt">
			<font style="display: inline;font-family:Times New Roman;font-weight:bold;font-size:10pt;">Item 7.&nbsp;&nbsp;&nbsp; </font><font style="display: inline;font-family:Times New Roman;font-weight:bold;font-size:10pt;text-decoration:underline;">Exemption From Registration Claimed</font><font style="display: inline;font-family:Times New Roman;font-weight:bold;font-size:10pt;">.</font><a name="Item7_ExemptionFromRegistrationCl_035917"></a>
		</p>
		<p style="margin:0pt;line-height:100%;font-family:Calibri;font-size: 10pt">
			<font style="display: inline;">&nbsp;</font>
		</p>
		<p style="margin:0pt;line-height:100%;text-indent:36pt;font-family:Calibri;font-size: 10pt">
			<font style="display: inline;font-family:Times New Roman;font-size:10pt;">Not applicable.</font>
		</p>
		<p style="margin:0pt;line-height:100%;font-family:Calibri;font-size: 10pt">
			<font style="display: inline;">&nbsp;</font>
		</p>
		<p style="margin:0pt;line-height:100%;font-family:Calibri;font-size: 10pt">

		</p>
		<p><font size="1"> </font></p><hr size="3" style="color:#999999" width="100%" align="center"></hr><p style="page-break-after:always">&nbsp;</p>
		<p style="margin:0pt;line-height:100%;font-family:Calibri;;font-size: 10pt"><font style="display: inline;font-family:Times New Roman;font-weight:bold;font-size:10pt;">Item 8.&nbsp;&nbsp;&nbsp; </font><font style="display: inline;font-family:Times New Roman;font-weight:bold;font-size:10pt;text-decoration:underline;">Exhibits</font><font style="display: inline;font-family:Times New Roman;font-weight:bold;font-size:10pt;">.</font><a name="Item8_Exhibits__035921"></a>
		</p>
		<p style="margin:0pt;line-height:100%;font-family:Calibri;font-size: 10pt">
			<font style="display: inline;">&nbsp;</font>
		</p>
		<div style="width:100%"><table cellpadding="0" cellspacing="0" style="border-collapse:collapse;width: 100.00%;margin-left:0pt;">
			<tr>
				<td valign="top" style="width:11.64%;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;border-right:1pt none #D9D9D9 ;height:1.00pt;padding:0pt;">
					<p style="margin:0pt 0pt 10pt;line-height:115%;font-family:Calibri;height:1.00pt;overflow:hidden;font-size: 1pt">
						<font style="display: inline;font-size:1pt;">&#xFEFF;</font></p>
				</td>
				<td valign="top" style="width:02.96%;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;border-right:1pt none #D9D9D9 ;height:1.00pt;padding:0pt;">
					<p style="margin:0pt 0pt 10pt;line-height:115%;font-family:Calibri;height:1.00pt;overflow:hidden;font-size:0pt;">
						&nbsp;</p>
				</td>
				<td valign="top" style="width:02.96%;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;border-right:1pt none #D9D9D9 ;height:1.00pt;padding:0pt;">
					<p style="margin:0pt 0pt 10pt;line-height:115%;font-family:Calibri;height:1.00pt;overflow:hidden;font-size:0pt;">
						&nbsp;</p>
				</td>
				<td valign="top" style="width:82.44%;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;border-right:1pt none #D9D9D9 ;height:1.00pt;padding:0pt;">
					<p style="margin:0pt 0pt 10pt;line-height:115%;font-family:Calibri;height:1.00pt;overflow:hidden;font-size:0pt;">
						&nbsp;</p>
				</td>
			</tr>
			<tr>
				<td colspan="2" valign="top" style="border-right:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;width:14.60%;padding:0pt 0pt 0pt 0pt;">
					<p style="margin:0pt;line-height:100%;text-align:center;font-family:Calibri;font-size: 9pt">
						<font style="display: inline;font-family:Times New Roman;font-weight:bold;font-size:9pt;">Exhibit Number</font></p>
				</td>
				<td valign="top" style="border-right:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;border-top:1pt none #D9D9D9 ;width:02.96%;padding:0pt 0pt 0pt 0pt;">
					<p style="margin:0pt;line-height:100%;text-align:center;font-family:Calibri;font-size: 11pt">
						&nbsp;</p>
				</td>
				<td valign="top" style="border-left:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;border-top:1pt none #D9D9D9 ;border-right:1pt none #D9D9D9 ;width:82.44%;padding:0pt 0pt 0pt 0pt;">
					<p style="margin:0pt;line-height:100%;text-align:center;font-family:Calibri;font-size: 9pt">
						<font style="display: inline;font-family:Times New Roman;font-weight:bold;font-size:9pt;">Description of Exhibit</font></p>
				</td>
			</tr>
			<tr>
				<td valign="top" style="border-right:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;width:11.64%;padding:0pt;">
					<p style="margin:0pt;line-height:100%;text-align:right;font-family:Calibri;font-size: 10pt">
						<font style="display: inline;font-family:Times New Roman;font-size:10pt;">&#xFEFF;</font><a href="sava-20220610xex5_1.htm" style="-sec-extract:exhibit"><font style="display: inline;font-family:Times New Roman;font-size:10pt;">5.1</font></a><font style="display: inline;font-family:Times New Roman;font-size:10pt;">*</font></p>
				</td>
				<td valign="top" style="border-right:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;border-top:1pt none #D9D9D9 ;width:02.96%;padding:0pt;">
					<p style="margin:0pt;line-height:100%;font-family:Calibri;font-size: 11pt">
						&nbsp;</p>
				</td>
				<td valign="top" style="border-right:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;border-top:1pt none #D9D9D9 ;width:02.96%;padding:0pt;">
					<p style="margin:0pt;line-height:100%;font-family:Calibri;font-size: 11pt">
						&nbsp;</p>
				</td>
				<td valign="top" style="border-left:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;border-top:1pt none #D9D9D9 ;border-right:1pt none #D9D9D9 ;width:82.44%;padding:0pt;">
					<p style="margin:0pt;line-height:100%;font-family:Calibri;font-size: 10pt">
						<a href="sava-20220610xex5_1.htm" style="-sec-extract:exhibit"><font style="display: inline;font-family:Times New Roman;font-size:10pt;">Opinion and Consent of Orrick, Herrington &amp; Sutcliffe LLP</font></a></p>
				</td>
			</tr>
			<tr>
				<td valign="top" style="border-right:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;width:11.64%;padding:0pt;">
					<p style="margin:0pt;line-height:100%;text-align:right;font-family:Calibri;font-size: 10pt">
						<font style="display: inline;font-family:Times New Roman;font-size:10pt;">&#xFEFF;</font><a href="sava-20220610xex23_1.htm" style="-sec-extract:exhibit"><font style="display: inline;font-family:Times New Roman;font-size:10pt;">23.1</font></a><font style="display: inline;font-family:Times New Roman;font-size:10pt;">*</font></p>
				</td>
				<td valign="top" style="border-right:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;border-top:1pt none #D9D9D9 ;width:02.96%;padding:0pt;">
					<p style="margin:0pt;line-height:100%;font-family:Calibri;font-size: 11pt">
						&nbsp;</p>
				</td>
				<td valign="top" style="border-right:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;border-top:1pt none #D9D9D9 ;width:02.96%;padding:0pt;">
					<p style="margin:0pt;line-height:100%;font-family:Calibri;font-size: 11pt">
						&nbsp;</p>
				</td>
				<td valign="top" style="border-left:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;border-top:1pt none #D9D9D9 ;border-right:1pt none #D9D9D9 ;width:82.44%;padding:0pt;">
					<p style="margin:0pt;line-height:100%;font-family:Calibri;font-size: 10pt">
						<a href="sava-20220610xex23_1.htm" style="-sec-extract:exhibit"><font style="display: inline;font-family:Times New Roman;font-size:10pt;">Consent of Independent Registered Public Accounting Firm</font></a></p>
				</td>
			</tr>
			<tr>
				<td valign="top" style="border-right:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;width:11.64%;padding:0pt;">
					<p style="margin:0pt;line-height:100%;text-align:right;font-family:Calibri;font-size: 10pt">
						<font style="display: inline;font-family:Times New Roman;font-size:10pt;">&#xFEFF;</font><a href="sava-20220610xex5_1.htm" style="-sec-extract:exhibit"><font style="display: inline;font-family:Times New Roman;font-size:10pt;">23.2</font></a></p>
				</td>
				<td valign="top" style="border-right:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;border-top:1pt none #D9D9D9 ;width:02.96%;padding:0pt;">
					<p style="margin:0pt;line-height:100%;font-family:Calibri;font-size: 11pt">
						&nbsp;</p>
				</td>
				<td valign="top" style="border-right:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;border-top:1pt none #D9D9D9 ;width:02.96%;padding:0pt;">
					<p style="margin:0pt;line-height:100%;font-family:Calibri;font-size: 11pt">
						&nbsp;</p>
				</td>
				<td valign="top" style="border-left:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;border-top:1pt none #D9D9D9 ;border-right:1pt none #D9D9D9 ;width:82.44%;padding:0pt;">
					<p style="margin:0pt;line-height:100%;font-family:Calibri;font-size: 10pt">
						<a href="sava-20220610xex5_1.htm" style="-sec-extract:exhibit"><font style="display: inline;font-family:Times New Roman;font-size:10pt;">Consent of Orrick, Herrington&nbsp;&amp; Sutcliffe LLP (included in Exhibit&nbsp;5.1 to this Registration Statement)</font></a></p>
				</td>
			</tr>
			<tr>
				<td valign="top" style="border-right:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;width:11.64%;padding:0pt;">
					<p style="margin:0pt;line-height:100%;text-align:right;font-family:Calibri;font-size: 10pt">
						<font style="display: inline;font-family:Times New Roman;font-size:10pt;">&#xFEFF;</font><a href="#PowerOfAttorney"><font style="display: inline;font-family:Times New Roman;font-size:10pt;">24.1</font></a></p>
				</td>
				<td valign="top" style="border-right:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;border-top:1pt none #D9D9D9 ;width:02.96%;padding:0pt;">
					<p style="margin:0pt;line-height:100%;font-family:Calibri;font-size: 11pt">
						&nbsp;</p>
				</td>
				<td valign="top" style="border-right:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;border-top:1pt none #D9D9D9 ;width:02.96%;padding:0pt;">
					<p style="margin:0pt;line-height:100%;font-family:Calibri;font-size: 11pt">
						&nbsp;</p>
				</td>
				<td valign="top" style="border-left:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;border-top:1pt none #D9D9D9 ;border-right:1pt none #D9D9D9 ;width:82.44%;padding:0pt;">
					<p style="margin:0pt;line-height:100%;font-family:Calibri;font-size: 10pt">
						<a href="#PowerOfAttorney"><font style="display: inline;font-family:Times New Roman;font-size:10pt;">Power of Attorney (filed as part of signature page).</font></a></p>
				</td>
			</tr>
			<tr>
				<td valign="top" style="border-right:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;width:11.64%;;font-family:Times New Roman;font-size:10pt;text-align:right;" nowrap="nowrap">99.1&nbsp;
				</td>
				<td valign="top" style="border-right:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;border-top:1pt none #D9D9D9 ;width:02.96%;padding:0pt;">
					<p style="margin:0pt;line-height:100%;font-family:Calibri;font-size: 11pt">
						&nbsp;</p>
				</td>
				<td valign="top" style="border-right:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;border-top:1pt none #D9D9D9 ;width:02.96%;padding:0pt;">
					<p style="margin:0pt;line-height:100%;font-family:Calibri;font-size: 11pt">
						&nbsp;</p>
				</td>
				<td valign="top" style="border-left:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;border-top:1pt none #D9D9D9 ;border-right:1pt none #D9D9D9 ;width:82.44%;padding:0pt;">
					<p style="margin:0pt;line-height:100%;font-family:Calibri;font-size: 10pt">
						<font style="display: inline;font-family:Times New Roman;font-size:10pt;">Cassava Sciences, Inc. 2018 Omnibus Incentive Plan, as amended </font><a name="OLE_LINK31"></a><a name="OLE_LINK32"></a><font style="display: inline;font-family:Times New Roman;font-size:10pt;">(incorporated herein by reference to </font><font style="display: inline;font-family:Times New Roman;font-size:10pt;">Appendix A</font><font style="display: inline;font-family:Times New Roman;font-size:10pt;">&nbsp;</font><font style="display: inline;font-family:Times New Roman;font-size:10pt;">and </font><a href="#Incentive_Plan"><font style="display: inline;font-family:Times New Roman;font-size:10pt;">Appendix B</font></a><font style="display: inline;font-family:Times New Roman;font-size:10pt;">&nbsp;</font><font style="display: inline;font-family:Times New Roman;font-size:10pt;">to Registrant&#x2019;s Definitive Proxy Statement on Schedule 14A filed on </font><font style="display: inline;font-family:Times New Roman;font-size:10pt;">March 24, 2022</font><font style="display: inline;font-family:Times New Roman;font-size:10pt;">)</font></p>
				</td>
			</tr>
			<tr>
				<td valign="top" style="border-right:1pt none #D9D9D9 ;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;width:11.64%;padding:0pt;">
					<p style="margin:0pt;line-height:100%;text-align:right;font-family:Calibri;font-size: 10pt">
						<font style="display: inline;font-family:Times New Roman;font-size:10pt;">&#xFEFF;</font><a href="sava-20220610xex10.htm" style="-sec-extract:exhibit"><font style="display: inline;font-family:Times New Roman;font-size:10pt;">107</font></a><font style="display: inline;font-family:Times New Roman;font-size:10pt;">*</font></p>
				</td>
				<td valign="top" style="border-right:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-top:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;width:02.96%;padding:0pt;">
					<p style="margin:0pt;line-height:100%;font-family:Calibri;font-size: 11pt">
						&nbsp;</p>
				</td>
				<td valign="top" style="border-right:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-top:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;width:02.96%;padding:0pt;">
					<p style="margin:0pt;line-height:100%;font-family:Calibri;font-size: 11pt">
						&nbsp;</p>
				</td>
				<td valign="top" style="border-left:1pt none #D9D9D9 ;border-top:1pt none #D9D9D9 ;border-right:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;width:82.44%;padding:0pt;">
					<p style="margin:0pt;line-height:100%;font-family:Calibri;font-size: 10pt">
						<a href="sava-20220610xex10.htm" style="-sec-extract:exhibit"><font style="display: inline;font-family:Times New Roman;font-size:10pt;">Filing Fee Table</font></a></p>
				</td>
			</tr>
		</table></div>
		<div style="width:100%"><table cellpadding="0" cellspacing="0" style="border-collapse:collapse;width: 100.00%;background-color: #FFFFFF;margin-left:0pt;">
			<tr>
				<td valign="top" style="width:02.00%;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;border-right:1pt none #D9D9D9 ;background-color: #FFFFFF;height:1.00pt;padding:0pt;">
					<p style="margin:0pt 0pt 10pt;line-height:115%;font-family:Calibri;height:1.00pt;overflow:hidden;font-size: 1pt">
						<font style="display: inline;font-size:1pt;">&#xFEFF;</font></p>
				</td>
				<td valign="top" style="width:98.00%;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;border-right:1pt none #D9D9D9 ;background-color: #FFFFFF;height:1.00pt;padding:0pt;">
					<p style="margin:0pt 0pt 10pt;line-height:115%;font-family:Calibri;height:1.00pt;overflow:hidden;font-size:0pt;">
						&nbsp;</p>
				</td>
			</tr>
			<tr>
				<td valign="top" style="width:02.00%;background-color: #FFFFFF;padding:0pt;">
					<p style="margin:0pt;line-height:100%;font-family:Calibri;font-size: 10pt">
						<font style="display: inline;font-family:Times New Roman;font-size:10pt;">*</font></p>
				</td>
				<td valign="top" style="width:98.00%;background-color: #FFFFFF;padding:0pt;">
					<p style="margin:0pt;line-height:100%;font-family:Calibri;font-size: 10pt">
						<font style="display: inline;font-family:Times New Roman;font-size:10pt;">Filed herewith.</font></p>
				</td>
			</tr>
		</table></div>
		<p style="margin:0pt;line-height:100%;font-family:Calibri;font-size: 11pt">
			<font style="display: inline;">&#xFEFF;</font>
		</p>
		<p style="margin:0pt;line-height:100%;font-family:Calibri;font-size: 10pt">
			<font style="display: inline;font-family:Times New Roman;font-weight:bold;font-size:10pt;">Item 9.&nbsp;&nbsp;&nbsp; </font><font style="display: inline;font-family:Times New Roman;font-weight:bold;font-size:10pt;text-decoration:underline;">Undertakings</font><font style="display: inline;font-family:Times New Roman;font-weight:bold;font-size:10pt;">.</font><a name="Item9_Undertakings__040249"></a>
		</p>
		<p style="margin:0pt;line-height:100%;font-family:Calibri;font-size: 10pt">
			<font style="display: inline;">&nbsp;</font>
		</p>
		<p style="margin:4.5pt 0pt 0pt;line-height:100%;text-indent:24.5pt;font-family:Calibri;font-size: 10pt">
			<font style="display: inline;font-family:Times New Roman;font-size:10pt;">(a)&nbsp;The undersigned Registrant hereby undertakes: </font>
		</p>
		<p style="margin:4.5pt 0pt 0pt 24.45pt;line-height:100%;text-indent:24.5pt;font-family:Calibri;font-size: 10pt">
			<font style="display: inline;font-family:Times New Roman;font-size:10pt;">(1)&nbsp;To file, during any period in which offers or sales are being made, a post-effective amendment to this Registration Statement: </font>
		</p>
		<p style="margin:4.5pt 0pt 0pt 48.95pt;line-height:100%;text-indent:24.5pt;font-family:Calibri;font-size: 10pt">
			<font style="display: inline;font-family:Times New Roman;font-size:10pt;">(i)&nbsp;To include any prospectus required by Section&nbsp;10(a)(3) of the Securities Act; </font>
		</p>
		<p style="margin:4.5pt 0pt 0pt 48.95pt;line-height:100%;text-indent:24.5pt;font-family:Calibri;font-size: 10pt">
			<font style="display: inline;font-family:Times New Roman;font-size:10pt;">(ii)&nbsp;To reflect in the prospectus any facts or events arising after the effective date of the </font><font style="display: inline;font-family:Times New Roman;font-size:10pt;">R</font><font style="display: inline;font-family:Times New Roman;font-size:10pt;">egistration </font><font style="display: inline;font-family:Times New Roman;font-size:10pt;">S</font><font style="display: inline;font-family:Times New Roman;font-size:10pt;">tatement (or the most recent post-effective amendment thereof) which, individually or in the aggregate, represent a fundamental change in the information set forth in the </font><a name="OLE_LINK15"></a><font style="display: inline;font-family:Times New Roman;font-size:10pt;">R</font><font style="display: inline;font-family:Times New Roman;font-size:10pt;">egistration </font><font style="display: inline;font-family:Times New Roman;font-size:10pt;">S</font><font style="display: inline;font-family:Times New Roman;font-size:10pt;">tatement</font><font style="display: inline;font-family:Times New Roman;font-size:10pt;">; and</font>
		</p>
		<p style="margin:4.5pt 0pt 0pt 48.95pt;line-height:100%;text-indent:24.5pt;font-family:Calibri;font-size: 10pt">
			<font style="display: inline;font-family:Times New Roman;font-size:10pt;">(iii)&nbsp;To include any material information with respect to the plan of distribution not previously disclosed in the </font><font style="display: inline;font-family:Times New Roman;font-size:10pt;">R</font><font style="display: inline;font-family:Times New Roman;font-size:10pt;">egistration </font><font style="display: inline;font-family:Times New Roman;font-size:10pt;">S</font><font style="display: inline;font-family:Times New Roman;font-size:10pt;">tatement or any material change to such information in the </font><font style="display: inline;font-family:Times New Roman;font-size:10pt;">R</font><font style="display: inline;font-family:Times New Roman;font-size:10pt;">egistration </font><font style="display: inline;font-family:Times New Roman;font-size:10pt;">S</font><font style="display: inline;font-family:Times New Roman;font-size:10pt;">tatement; </font>
		</p>
		<p style="margin:4.5pt 0pt 0pt 24.45pt;line-height:100%;font-family:Calibri;font-size: 10pt">
			<font style="display: inline;font-family:Times New Roman;font-style:italic;font-size:10pt;">provided, however</font><font style="display: inline;font-family:Times New Roman;font-size:10pt;">,</font><font style="display: inline;font-family:Times New Roman;font-style:italic;font-size:10pt;">&nbsp;</font><font style="display: inline;font-family:Times New Roman;font-size:10pt;">that paragraphs (a)(1)(i) and (a)(1)(ii) of this section do not apply if the information required to be included in a post-effective amendment by those paragraphs is contained in reports filed with or furnished to the Commission by the Registrant pursuant to Section&nbsp;13 or Section&nbsp;15(d) of the Exchange Act that are incorporated by reference in the </font><font style="display: inline;font-family:Times New Roman;font-size:10pt;">R</font><font style="display: inline;font-family:Times New Roman;font-size:10pt;">egistration </font><font style="display: inline;font-family:Times New Roman;font-size:10pt;">S</font><font style="display: inline;font-family:Times New Roman;font-size:10pt;">tatement. </font>
		</p>
		<p style="margin:4.5pt 0pt 0pt 24.45pt;line-height:100%;text-indent:24.5pt;font-family:Calibri;font-size: 10pt">
			<font style="display: inline;font-family:Times New Roman;font-size:10pt;">(2)&nbsp;That, for the purpose of determining any liability under the Securities Act, each such post-effective amendment shall be deemed to be a new </font><font style="display: inline;font-family:Times New Roman;font-size:10pt;">R</font><font style="display: inline;font-family:Times New Roman;font-size:10pt;">egistration </font><font style="display: inline;font-family:Times New Roman;font-size:10pt;">S</font><font style="display: inline;font-family:Times New Roman;font-size:10pt;">tatement relating to the securities offered therein, and the offering of such securities at that time shall be deemed to be the initial bona fide offering thereof. </font>
		</p>
		<p style="margin:4.5pt 0pt 0pt 24.45pt;line-height:100%;text-indent:24.5pt;font-family:Calibri;font-size: 10pt">
			<font style="display: inline;font-family:Times New Roman;font-size:10pt;">(3)&nbsp;To remove from registration by means of a post-effective amendment any of the securities being registered which remain unsold at the termination of the offering. </font>
		</p>
		<p style="margin:4.5pt 0pt 0pt;line-height:100%;text-indent:24.5pt;font-family:Calibri;font-size: 10pt">
			<font style="display: inline;font-family:Times New Roman;font-size:10pt;">(b)&nbsp;</font><font style="display: inline;font-family:Times New Roman;font-size:10pt;">The Registrant hereby undertakes that, for purposes of determining any liability under the Securities Act, each filing of the Registrant&#x2019;s annual report pursuant to Section 13(a) or Section 15(d) of the Exchange Act that is incorporated by reference in the Registration Statement shall be deemed to be a new Registration Statement relating to the securities offered therein, and the offering of such securities at that time shall be deemed to be the initial bona fide offering thereof.</font>
		</p>
		<p style="margin:0pt;line-height:100%;font-family:Calibri;font-size: 7pt">
			<font style="display: inline;">&nbsp;</font>
		</p>
		<p style="margin:0pt;line-height:100%;text-indent:24.5pt;font-family:Calibri;font-size: 10pt">
			<font style="display: inline;font-family:Times New Roman;font-size:10pt;">(c)&nbsp;</font><font style="display: inline;font-family:Times New Roman;font-size:10pt;">Insofar as indemnification for liabilities arising under the Securities Act may be permitted to directors, officers and controlling persons of the Registrant pursuant to the foregoing provisions, or otherwise, the Registrant has been advised that in the opinion of the Commission such indemnification is against public policy as expressed in the Securities Act and is, therefore, unenforceable. In the event that a claim for indemnification against such liabilities (other than the payment by the Registrant of expenses incurred or paid by a director, officer or controlling person of the Registrant in the successful defense of any action, suit or proceeding) is asserted by such director, officer or controlling person in connection with the securities being registered, the Registrant will, unless in the opinion of its counsel the matter has been settled by controlling precedent, submit to a court of appropriate jurisdiction the question whether such indemnification by it is against public policy as expressed in the Securities Act and will be governed by the final adjudication of such issue.</font>
		</p>
		<p style="margin:0pt;line-height:100%;text-align:center;font-family:Calibri;font-size: 10pt">
			<font style="display: inline;">&nbsp;</font>
		</p>
		<p style="margin:0pt;line-height:100%;text-align:center;font-family:Calibri;font-size: 10pt">
			<font style="display: inline;">&nbsp;</font>
		</p>
		<p style="margin:0pt;line-height:100%;text-align:center;font-family:Calibri;font-size: 10pt">

		</p>
		<p><font size="1"> </font></p><hr size="3" style="color:#999999" width="100%" align="center"></hr><p style="page-break-after:always">&nbsp;</p>
		<p style="margin:0pt;line-height:100%;text-align:center;font-family:Calibri;;font-size: 10pt"><font style="display: inline;font-family:Times New Roman;font-weight:bold;font-size:10pt;"></font><font style="display: inline;font-family:Times New Roman;font-weight:bold;font-size:10pt;">SIGNATURES</font><a name="Signatures_041836"></a>
		</p>
		<p style="margin:0pt;line-height:100%;text-align:center;font-family:Calibri;font-size: 10pt">
			<font style="display: inline;">&nbsp;</font>
		</p>
		<p style="margin:9pt 0pt 0pt;line-height:100%;text-indent:24.5pt;font-family:Calibri;font-size: 10pt">
			<font style="display: inline;font-family:Times New Roman;font-size:10pt;">Pursuant to the requirements of the Securities Act, the Registrant certifies that it has reasonable grounds to believe that it meets all of the requirements for filing on Form&nbsp;S-8 and has duly caused this Registration Statement to be signed on its behalf by the undersigned, thereunto duly authorized, in the City of </font><font style="display: inline;font-family:Times New Roman;font-size:10pt;">Austin</font><font style="display: inline;font-family:Times New Roman;font-size:10pt;">, State of </font><font style="display: inline;font-family:Times New Roman;font-size:10pt;">Texas</font><font style="display: inline;font-family:Times New Roman;font-size:10pt;">, on </font><font style="display: inline;font-family:Times New Roman;font-size:10pt;">June 10, 2022</font><font style="display: inline;font-family:Times New Roman;font-size:10pt;">.</font>
		</p>
		<p style="margin:0pt;line-height:100%;font-family:Calibri;font-size: 10pt">
			<font style="display: inline;">&nbsp;</font>
		</p>
		<div style="width:100%"><table cellpadding="0" cellspacing="0" style="border-collapse:collapse;width: 100.00%;margin-left:0pt;">
			<tr>
				<td valign="top" style="border-right:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-top:1pt none #D9D9D9 ;width:auto;padding:0pt;">
					<p style="margin:0pt;line-height:100%;font-family:Calibri;font-size: 10pt">
						<font style="display: inline;font-family:Times New Roman;font-size:10pt;">&#xFEFF;</font></p>
				</td>
				<td colspan="3" valign="top" style="border-left:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;border-right:1pt none #D9D9D9 ;border-top:1pt none #D9D9D9 ;width:181.00pt;padding:0pt;">
					<p style="margin:0pt;line-height:100%;font-family:Calibri;font-size: 10pt">
						<font style="display: inline;font-family:Times New Roman;font-size:10pt;">Cassava Sciences, Inc</font><font style="display: inline;font-family:Times New Roman;font-size:10pt;">.</font></p>
				</td>
			</tr>
			<tr>
				<td valign="top" style="border-right:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;width:auto;padding:0pt;">
					<p style="margin:0pt;line-height:100%;font-family:Calibri;font-size: 10pt">
						<font style="display: inline;font-family:Times New Roman;font-size:10pt;">&#xFEFF;</font></p>
				</td>
				<td valign="top" style="border-right:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;border-top:1pt none #D9D9D9 ;width:14.45pt;padding:0pt;">
					<p style="margin:0pt;line-height:100%;font-family:Calibri;font-size: 11pt">
						&nbsp;</p>
				</td>
				<td valign="top" style="border-right:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;border-top:1pt none #D9D9D9 ;width:13.50pt;padding:0pt;">
					<p style="margin:0pt;line-height:100%;font-family:Calibri;font-size: 11pt">
						&nbsp;</p>
				</td>
				<td valign="top" style="border-left:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;border-top:1pt none #D9D9D9 ;border-right:1pt none #D9D9D9 ;width:153.05pt;padding:0pt;">
					<p style="margin:0pt;line-height:100%;font-family:Calibri;font-size: 11pt">
						&nbsp;</p>
				</td>
			</tr>
			<tr>
				<td valign="top" style="border-right:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;width:auto;padding:0pt;">
					<p style="margin:0pt;line-height:100%;font-family:Calibri;font-size: 10pt">
						<font style="display: inline;font-family:Times New Roman;font-size:10pt;">&#xFEFF;</font></p>
				</td>
				<td valign="top" style="border-right:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;border-top:1pt none #D9D9D9 ;width:14.45pt;padding:0pt;">
					<p style="margin:0pt;line-height:100%;font-family:Calibri;font-size: 10pt">
						<font style="display: inline;font-family:Times New Roman;font-size:10pt;">By:</font></p>
				</td>
				<td valign="top" style="border-right:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;border-top:1pt none #D9D9D9 ;width:13.50pt;padding:0pt;">
					<p style="margin:0pt;line-height:100%;font-family:Calibri;font-size: 11pt">
						&nbsp;</p>
				</td>
				<td valign="top" style="border-left:1pt none #D9D9D9 ;border-top:1pt none #D9D9D9 ;border-right:1pt none #D9D9D9 ;width:153.05pt;border-bottom:1pt solid #000000 ;padding:0pt;">
					<p style="margin:0pt;line-height:100%;font-family:Calibri;font-size: 10pt">
						<font style="display: inline;font-family:Times New Roman;font-size:10pt;">/s/ Remi Barbier</font></p>
				</td>
			</tr>
			<tr>
				<td valign="top" style="border-right:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;width:auto;padding:0pt;">
					<p style="margin:0pt;line-height:100%;font-family:Calibri;font-size: 10pt">
						<font style="display: inline;font-family:Times New Roman;font-size:10pt;">&#xFEFF;</font></p>
				</td>
				<td valign="top" style="border-right:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;border-top:1pt none #D9D9D9 ;width:14.45pt;padding:0pt;">
					<p style="margin:0pt;line-height:100%;font-family:Calibri;font-size: 11pt">
						&nbsp;</p>
				</td>
				<td colspan="2" valign="top" style="border-left:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;border-top:1pt none #D9D9D9 ;border-right:1pt none #D9D9D9 ;width:166.55pt;padding:0pt;">
					<p style="margin:0pt;line-height:100%;font-family:Calibri;font-size: 10pt">
						<font style="display: inline;font-family:Times New Roman;font-size:10pt;">Remi Barbier</font></p>
				</td>
			</tr>
			<tr>
				<td valign="top" style="border-right:1pt none #D9D9D9 ;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;width:auto;padding:0pt;">
					<p style="margin:0pt;line-height:100%;font-family:Calibri;font-size: 10pt">
						<font style="display: inline;font-family:Times New Roman;font-size:10pt;">&#xFEFF;</font></p>
				</td>
				<td valign="top" style="border-right:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-top:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;width:14.45pt;padding:0pt;">
					<p style="margin:0pt;line-height:100%;font-family:Calibri;font-size: 11pt">
						&nbsp;</p>
				</td>
				<td colspan="2" valign="top" style="border-left:1pt none #D9D9D9 ;border-top:1pt none #D9D9D9 ;border-right:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;width:166.55pt;padding:0pt;">
					<p style="margin:0pt;line-height:100%;font-family:Calibri;font-size: 10pt">
						<font style="display: inline;font-family:Times New Roman;font-size:10pt;">Chairman of the Board of Directors, President and Chief Executive Officer</font></p>
				</td>
			</tr>
		</table></div>
		<p style="margin:18pt 0pt 0pt;line-height:100%;text-align:center;font-family:Calibri;font-size: 10pt">
			<font style="display: inline;font-family:Times New Roman;font-weight:bold;font-size:10pt;">POWER OF ATTORN</font><a name="PowerOfAttorney"></a><font style="display: inline;font-family:Times New Roman;font-weight:bold;font-size:10pt;">EY </font>
		</p>
		<p style="margin:9pt 0pt 0pt;line-height:100%;text-indent:24.5pt;font-family:Calibri;font-size: 10pt">
			<font style="display: inline;font-family:Times New Roman;font-size:10pt;">KNOW ALL PERSONS BY THESE PRESENTS, that each person whose signature appears below hereby constitutes and appoints, jointly and severally, </font><font style="display: inline;font-family:Times New Roman;font-size:10pt;">Remi Barbier</font><font style="display: inline;font-family:Times New Roman;font-size:10pt;"> and Eric J. Schoen</font><font style="display: inline;font-family:Times New Roman;font-size:10pt;"> as his or her true and lawful attorney-in-fact and agent, with full power of substitution and revocation, in his or her name and on his or her behalf, in any and all capacities, to sign any or all amendments (including post-effective amendments) to this Registration Statement, and to file the same, with all exhibits thereto, and other documents in connection therewith, with the Commission, granting unto said attorneys-in-fact and agents full power and authority to do and perform each and every act and thing requisite and necessary to be done in and about the premises, as fully for all intents and purposes as he or she might or could do in person, hereby ratifying and confirming all that said attorneys-in-fact and agents, or their substitutes, may lawfully do or cause to be done by virtue hereof.</font>
		</p>
		<p style="margin:9pt 0pt 24pt;line-height:100%;text-indent:24.5pt;font-family:Calibri;font-size: 10pt">
			<font style="display: inline;font-family:Times New Roman;font-size:10pt;">Pursuant to the requirements of the Securities Act, this Registration Statement has been signed by the following persons in the capacities and on the dates indicated. </font>
		</p>
		<div style="width:100%"><table cellpadding="0" cellspacing="0" style="border-collapse:collapse;width:472.50pt;margin-left:18pt;">
			<tr>
				<td valign="top" style="width:193.50pt;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;border-right:1pt none #D9D9D9 ;background-color: #auto;height:1.00pt;padding:0pt 6.5pt">
					<p style="margin:0pt 0pt 10pt;line-height:115%;font-family:Calibri;height:1.00pt;overflow:hidden;font-size: 10pt">
						<font style="display: inline;font-family:Times New Roman;font-size:10pt;">n</font></p>
				</td>
				<td valign="top" style="width:18.00pt;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;border-right:1pt none #D9D9D9 ;background-color: #auto;height:1.00pt;padding:0pt 6.5pt">
					<p style="margin:0pt 0pt 10pt;line-height:115%;font-family:Calibri;height:1.00pt;overflow:hidden;font-size:0pt;">
						&nbsp;</p>
				</td>
				<td valign="top" style="width:144.00pt;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;border-right:1pt none #D9D9D9 ;background-color: #auto;height:1.00pt;padding:0pt 6.5pt">
					<p style="margin:0pt 0pt 10pt;line-height:115%;font-family:Calibri;height:1.00pt;overflow:hidden;font-size:0pt;">
						&nbsp;</p>
				</td>
				<td valign="top" style="width:18.00pt;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;border-right:1pt none #D9D9D9 ;background-color: #auto;height:1.00pt;padding:0pt 6.5pt">
					<p style="margin:0pt 0pt 10pt;line-height:115%;font-family:Calibri;height:1.00pt;overflow:hidden;font-size:0pt;">
						&nbsp;</p>
				</td>
				<td valign="top" style="width:99.00pt;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;border-right:1pt none #D9D9D9 ;background-color: #auto;height:1.00pt;padding:0pt 6.5pt">
					<p style="margin:0pt 0pt 10pt;line-height:115%;font-family:Calibri;height:1.00pt;overflow:hidden;font-size:0pt;">
						&nbsp;</p>
				</td>
			</tr>
			<tr>
				<td valign="top" style="width:193.50pt;border-bottom:1pt solid #000000 ;background-color: #auto;padding:0pt 6.5pt">
					<p style="margin:0pt;line-height:120%;text-align:center;font-family:Calibri;font-size: 10pt">
						<font style="display: inline;font-family:Times New Roman;font-weight:bold;font-size:10pt;">Name</font></p>
				</td>
				<td valign="top" style="width:18.00pt;background-color: #auto;padding:0pt 6.5pt">
					<p style="margin:0pt;line-height:120%;font-family:Calibri;font-size: 11pt">
						&nbsp;</p>
				</td>
				<td valign="top" style="width:144.00pt;border-bottom:1pt solid #000000 ;background-color: #auto;padding:0pt 6.5pt">
					<p style="margin:0pt;line-height:120%;text-align:center;font-family:Calibri;font-size: 10pt">
						<font style="display: inline;font-family:Times New Roman;font-weight:bold;font-size:10pt;">Title</font></p>
				</td>
				<td valign="top" style="width:18.00pt;background-color: #auto;padding:0pt 6.5pt">
					<p style="margin:0pt;line-height:120%;font-family:Calibri;font-size: 11pt">
						&nbsp;</p>
				</td>
				<td valign="top" style="width:99.00pt;border-bottom:1pt solid #000000 ;background-color: #auto;padding:0pt 6.5pt">
					<p style="margin:0pt;line-height:120%;text-align:center;font-family:Calibri;font-size: 10pt">
						<font style="display: inline;font-family:Times New Roman;font-weight:bold;font-size:10pt;">Date</font></p>
				</td>
			</tr>
			<tr>
				<td valign="top" style="width:193.50pt;border-top:1pt solid #000000 ;background-color: #auto;padding:0pt 6.5pt">
					<p style="margin:0pt;line-height:120%;text-align:center;font-family:Calibri;font-size: 10pt">
						<font style="display: inline;font-family:Times New Roman;font-size:10pt;">&#xFEFF;</font></p>
				</td>
				<td valign="top" style="width:18.00pt;background-color: #auto;padding:0pt 6.5pt">
					<p style="margin:0pt;line-height:120%;font-family:Calibri;font-size: 11pt">
						&nbsp;</p>
				</td>
				<td valign="top" style="width:144.00pt;border-top:1pt solid #000000 ;background-color: #auto;padding:0pt 6.5pt">
					<p style="margin:0pt;line-height:120%;text-align:center;font-family:Calibri;font-size: 11pt">
						&nbsp;</p>
				</td>
				<td valign="top" style="width:18.00pt;background-color: #auto;padding:0pt 6.5pt">
					<p style="margin:0pt;line-height:120%;font-family:Calibri;font-size: 11pt">
						&nbsp;</p>
				</td>
				<td valign="top" style="width:99.00pt;border-top:1pt solid #000000 ;background-color: #auto;padding:0pt 6.5pt">
					<p style="margin:0pt;line-height:120%;text-align:center;font-family:Calibri;font-size: 11pt">
						&nbsp;</p>
				</td>
			</tr>
			<tr>
				<td valign="top" style="width:193.50pt;background-color: #auto;padding:0pt 6.5pt">
					<p style="margin:0pt 3.7pt 0pt 0pt;line-height:120%;text-align:center;border-bottom:1pt solid #000000 ;font-family:Calibri;font-size: 10pt">
						<font style="display: inline;font-family:Times New Roman;font-size:10pt;">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;/s/ </font><font style="display: inline;font-family:Times New Roman;font-size:10pt;">Remi Barbier</font><font style="display: inline;font-family:Times New Roman;font-size:10pt;">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</font><br /><font style="display: inline;font-family:Times New Roman;font-size:10pt;"> &nbsp; </font><font style="display: inline;font-family:Times New Roman;font-size:10pt;">Remi Barbier</font></p>
				</td>
				<td valign="top" style="width:18.00pt;background-color: #auto;padding:0pt 6.5pt">
					<p style="margin:0pt;line-height:120%;font-family:Calibri;font-size: 11pt">
						&nbsp;</p>
				</td>
				<td valign="top" style="width:144.00pt;background-color: #auto;padding:0pt 6.5pt">
					<p style="margin:0pt;line-height:120%;text-align:center;font-family:Calibri;font-size: 10pt">
						<font style="display: inline;font-family:Times New Roman;font-size:10pt;">Chairman of the Board of Directors, </font><font style="display: inline;font-family:Times New Roman;font-size:10pt;">President and Chief Executive</font><br /><font style="display: inline;font-family:Times New Roman;font-size:10pt;">Officer</font><br /><font style="display: inline;font-family:Times New Roman;font-size:10pt;">(Principal Executive Officer)</font></p>
				</td>
				<td valign="top" style="width:18.00pt;background-color: #auto;padding:0pt 6.5pt">
					<p style="margin:0pt;line-height:120%;font-family:Calibri;font-size: 11pt">
						&nbsp;</p>
				</td>
				<td valign="top" style="width:99.00pt;background-color: #auto;padding:0pt 6.5pt">
					<p style="margin:0pt;line-height:120%;text-align:center;font-family:Calibri;font-size: 10pt">
						<font style="display: inline;font-family:Times New Roman;font-size:10pt;">June 10, 2022</font></p>
				</td>
			</tr>
			<tr>
				<td valign="top" style="width:193.50pt;background-color: #auto;padding:0pt 6.5pt">
					<p style="margin:0pt 3.7pt 0pt 0pt;line-height:120%;text-align:center;font-family:Calibri;font-size: 10pt">
						<font style="display: inline;font-family:Times New Roman;font-size:10pt;text-decoration:underline;">&#xFEFF;</font></p>
				</td>
				<td valign="top" style="width:18.00pt;background-color: #auto;padding:0pt 6.5pt">
					<p style="margin:0pt;line-height:120%;font-family:Calibri;font-size: 11pt">
						&nbsp;</p>
				</td>
				<td valign="top" style="width:144.00pt;background-color: #auto;padding:0pt 6.5pt">
					<p style="margin:0pt;line-height:100%;text-align:center;font-family:Calibri;font-size: 11pt">
						&nbsp;</p>
				</td>
				<td valign="top" style="width:18.00pt;background-color: #auto;padding:0pt 6.5pt">
					<p style="margin:0pt;line-height:120%;font-family:Calibri;font-size: 11pt">
						&nbsp;</p>
				</td>
				<td valign="top" style="width:99.00pt;background-color: #auto;padding:0pt 6.5pt">
					<p style="margin:0pt;line-height:120%;text-align:center;font-family:Calibri;font-size: 11pt">
						&nbsp;</p>
				</td>
			</tr>
			<tr>
				<td valign="top" style="width:193.50pt;background-color: #auto;padding:0pt 6.5pt">
					<p style="margin:0pt 3.7pt 0pt 0pt;line-height:120%;text-align:center;border-bottom:1pt solid #000000 ;font-family:Calibri;font-size: 10pt">
						<font style="display: inline;font-family:Times New Roman;font-size:10pt;">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;/s/ </font><font style="display: inline;font-family:Times New Roman;font-size:10pt;">Eric Schoen</font><font style="display: inline;font-family:Times New Roman;font-size:10pt;">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</font><br /><font style="display: inline;font-family:Times New Roman;font-size:10pt;">&nbsp;</font><font style="display: inline;font-family:Times New Roman;font-size:10pt;">Eric Schoen</font></p>
				</td>
				<td valign="top" style="width:18.00pt;background-color: #auto;padding:0pt 6.5pt">
					<p style="margin:0pt;line-height:120%;font-family:Calibri;font-size: 11pt">
						&nbsp;</p>
				</td>
				<td valign="top" style="width:144.00pt;background-color: #auto;padding:0pt 6.5pt">
					<p style="margin:0pt;line-height:120%;text-align:center;font-family:Calibri;font-size: 10pt">
						<font style="display: inline;font-family:Times New Roman;font-size:10pt;">Chief Financial Officer</font><br /><font style="display: inline;font-family:Times New Roman;font-size:10pt;">(Principal Financial Officer)</font></p>
				</td>
				<td valign="top" style="width:18.00pt;background-color: #auto;padding:0pt 6.5pt">
					<p style="margin:0pt;line-height:120%;font-family:Calibri;font-size: 11pt">
						&nbsp;</p>
				</td>
				<td valign="top" style="width:99.00pt;background-color: #auto;padding:0pt 6.5pt">
					<p style="margin:0pt;line-height:120%;text-align:center;font-family:Calibri;font-size: 10pt">
						<font style="display: inline;font-family:Times New Roman;font-size:10pt;">June 10, 2022</font></p>
				</td>
			</tr>
			<tr>
				<td valign="top" style="width:193.50pt;background-color: #auto;padding:0pt 6.5pt">
					<p style="margin:0pt;line-height:120%;text-align:center;font-family:Calibri;font-size: 10pt">
						<font style="display: inline;font-family:Times New Roman;font-size:10pt;">&#xFEFF;</font></p>
				</td>
				<td valign="top" style="width:18.00pt;background-color: #auto;padding:0pt 6.5pt">
					<p style="margin:0pt;line-height:120%;font-family:Calibri;font-size: 11pt">
						&nbsp;</p>
				</td>
				<td valign="top" style="width:144.00pt;background-color: #auto;padding:0pt 6.5pt">
					<p style="margin:0pt;line-height:120%;text-align:center;font-family:Calibri;font-size: 11pt">
						&nbsp;</p>
				</td>
				<td valign="top" style="width:18.00pt;background-color: #auto;padding:0pt 6.5pt">
					<p style="margin:0pt;line-height:120%;font-family:Calibri;font-size: 11pt">
						&nbsp;</p>
				</td>
				<td valign="top" style="width:99.00pt;background-color: #auto;padding:0pt 6.5pt">
					<p style="margin:0pt;line-height:120%;text-align:center;font-family:Calibri;font-size: 11pt">
						&nbsp;</p>
				</td>
			</tr>
			<tr>
				<td valign="top" style="width:193.50pt;background-color: #auto;padding:0pt 6.5pt">
					<p style="margin:0pt;line-height:120%;text-align:center;border-bottom:1pt solid #000000 ;font-family:Calibri;font-size: 10pt">
						<font style="display: inline;font-family:Times New Roman;font-size:10pt;">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;/s/ </font><font style="display: inline;font-family:Times New Roman;font-size:10pt;">Nadav Friedmann, PhD, MD</font><font style="display: inline;font-family:Times New Roman;font-size:10pt;">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</font><br /><font style="display: inline;font-family:Times New Roman;font-size:10pt;"> &nbsp; </font><font style="display: inline;font-family:Times New Roman;font-size:10pt;">Nadav Friedmann, PhD, MD</font></p>
				</td>
				<td valign="top" style="width:18.00pt;background-color: #auto;padding:0pt 6.5pt">
					<p style="margin:0pt;line-height:120%;font-family:Calibri;font-size: 11pt">
						&nbsp;</p>
				</td>
				<td valign="top" style="width:144.00pt;background-color: #auto;padding:0pt 6.5pt">
					<p style="margin:0pt 0pt 0pt 9.6pt;line-height:100%;text-align:center;font-family:Calibri;font-size: 10pt">
						<font style="display: inline;font-family:Times New Roman;font-size:10pt;">Chief Medical Officer and Director</font></p>
				</td>
				<td valign="top" style="width:18.00pt;background-color: #auto;padding:0pt 6.5pt">
					<p style="margin:0pt;line-height:120%;font-family:Calibri;font-size: 11pt">
						&nbsp;</p>
				</td>
				<td valign="top" style="width:99.00pt;background-color: #auto;padding:0pt 6.5pt">
					<p style="margin:0pt;line-height:120%;text-align:center;font-family:Calibri;font-size: 10pt">
						<font style="display: inline;font-family:Times New Roman;font-size:10pt;">June 10, 2022</font></p>
				</td>
			</tr>
			<tr>
				<td valign="top" style="width:193.50pt;background-color: #auto;padding:0pt 6.5pt">
					<p style="margin:0pt;line-height:120%;text-align:center;font-family:Calibri;font-size: 10pt">
						<font style="display: inline;font-family:Times New Roman;font-size:10pt;">&#xFEFF;</font></p>
				</td>
				<td valign="top" style="width:18.00pt;background-color: #auto;padding:0pt 6.5pt">
					<p style="margin:0pt;line-height:120%;font-family:Calibri;font-size: 11pt">
						&nbsp;</p>
				</td>
				<td valign="top" style="width:144.00pt;background-color: #auto;padding:0pt 6.5pt">
					<p style="margin:0pt;line-height:120%;text-align:center;font-family:Calibri;font-size: 11pt">
						&nbsp;</p>
				</td>
				<td valign="top" style="width:18.00pt;background-color: #auto;padding:0pt 6.5pt">
					<p style="margin:0pt;line-height:120%;font-family:Calibri;font-size: 11pt">
						&nbsp;</p>
				</td>
				<td valign="top" style="width:99.00pt;background-color: #auto;padding:0pt 6.5pt">
					<p style="margin:0pt;line-height:120%;text-align:center;font-family:Calibri;font-size: 11pt">
						&nbsp;</p>
				</td>
			</tr>
			<tr>
				<td valign="top" style="width:193.50pt;background-color: #auto;padding:0pt 6.5pt">
					<p style="margin:0pt;line-height:120%;text-align:center;border-bottom:1pt solid #000000 ;font-family:Calibri;font-size: 10pt">
						<font style="display: inline;font-family:Times New Roman;font-size:10pt;">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;/s/ </font><font style="display: inline;font-family:Times New Roman;font-size:10pt;">Sanford R. Robertson</font><font style="display: inline;font-family:Times New Roman;font-size:10pt;">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</font><br /><font style="display: inline;font-family:Times New Roman;font-size:10pt;"> &nbsp;&nbsp; </font><font style="display: inline;font-family:Times New Roman;font-size:10pt;">Sanford R. Robertson</font></p>
				</td>
				<td valign="top" style="width:18.00pt;background-color: #auto;padding:0pt 6.5pt">
					<p style="margin:0pt;line-height:120%;font-family:Calibri;font-size: 11pt">
						&nbsp;</p>
				</td>
				<td valign="top" style="width:144.00pt;background-color: #auto;padding:0pt 6.5pt">
					<p style="margin:0pt;line-height:120%;text-align:center;font-family:Calibri;font-size: 10pt">
						<font style="display: inline;font-family:Times New Roman;font-size:10pt;">Director</font></p>
				</td>
				<td valign="top" style="width:18.00pt;background-color: #auto;padding:0pt 6.5pt">
					<p style="margin:0pt;line-height:120%;font-family:Calibri;font-size: 11pt">
						&nbsp;</p>
				</td>
				<td valign="top" style="width:99.00pt;background-color: #auto;padding:0pt 6.5pt">
					<p style="margin:0pt;line-height:120%;text-align:center;font-family:Calibri;font-size: 10pt">
						<font style="display: inline;font-family:Times New Roman;font-size:10pt;">June 10, 2022</font></p>
				</td>
			</tr>
			<tr>
				<td valign="top" style="width:193.50pt;background-color: #auto;padding:0pt 6.5pt">
					<p style="margin:0pt;line-height:120%;text-align:center;font-family:Calibri;font-size: 10pt">
						<font style="display: inline;font-family:Times New Roman;font-size:10pt;text-decoration:underline;">&#xFEFF;</font></p>
				</td>
				<td valign="top" style="width:18.00pt;background-color: #auto;padding:0pt 6.5pt">
					<p style="margin:0pt;line-height:120%;font-family:Calibri;font-size: 11pt">
						&nbsp;</p>
				</td>
				<td valign="top" style="width:144.00pt;background-color: #auto;padding:0pt 6.5pt">
					<p style="margin:0pt;line-height:120%;text-align:center;font-family:Calibri;font-size: 11pt">
						&nbsp;</p>
				</td>
				<td valign="top" style="width:18.00pt;background-color: #auto;padding:0pt 6.5pt">
					<p style="margin:0pt;line-height:120%;font-family:Calibri;font-size: 11pt">
						&nbsp;</p>
				</td>
				<td valign="top" style="width:99.00pt;background-color: #auto;padding:0pt 6.5pt">
					<p style="margin:0pt;line-height:120%;text-align:center;font-family:Calibri;font-size: 11pt">
						&nbsp;</p>
				</td>
			</tr>
			<tr>
				<td valign="top" style="width:193.50pt;background-color: #auto;padding:0pt 6.5pt">
					<p style="margin:0pt;line-height:120%;text-align:center;border-bottom:1pt solid #000000 ;font-family:Calibri;font-size: 10pt">
						<font style="display: inline;font-family:Times New Roman;font-size:10pt;">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;/s/ </font><font style="display: inline;font-family:Times New Roman;font-size:10pt;">Richard J. Barry</font><font style="display: inline;font-family:Times New Roman;font-size:10pt;">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</font><br /><font style="display: inline;font-family:Times New Roman;font-size:10pt;"> &nbsp; </font><font style="display: inline;font-family:Times New Roman;font-size:10pt;">Richard J. Barry</font></p>
				</td>
				<td valign="top" style="width:18.00pt;background-color: #auto;padding:0pt 6.5pt">
					<p style="margin:0pt;line-height:120%;font-family:Calibri;font-size: 11pt">
						&nbsp;</p>
				</td>
				<td valign="top" style="width:144.00pt;background-color: #auto;padding:0pt 6.5pt">
					<p style="margin:0pt;line-height:120%;text-align:center;font-family:Calibri;font-size: 10pt">
						<font style="display: inline;font-family:Times New Roman;font-size:10pt;">Director</font></p>
				</td>
				<td valign="top" style="width:18.00pt;background-color: #auto;padding:0pt 6.5pt">
					<p style="margin:0pt;line-height:120%;font-family:Calibri;font-size: 11pt">
						&nbsp;</p>
				</td>
				<td valign="top" style="width:99.00pt;background-color: #auto;padding:0pt 6.5pt">
					<p style="margin:0pt;line-height:120%;text-align:center;font-family:Calibri;font-size: 10pt">
						<font style="display: inline;font-family:Times New Roman;font-size:10pt;">June 10, 2022</font></p>
				</td>
			</tr>
			<tr>
				<td valign="top" style="width:193.50pt;background-color: #auto;padding:0pt 6.5pt">
					<p style="margin:0pt;line-height:120%;text-align:center;font-family:Calibri;font-size: 10pt">
						<font style="display: inline;font-family:Times New Roman;font-size:10pt;text-decoration:underline;">&#xFEFF;</font></p>
				</td>
				<td valign="top" style="width:18.00pt;background-color: #auto;padding:0pt 6.5pt">
					<p style="margin:0pt;line-height:120%;font-family:Calibri;font-size: 11pt">
						&nbsp;</p>
				</td>
				<td valign="top" style="width:144.00pt;background-color: #auto;padding:0pt 6.5pt">
					<p style="margin:0pt;line-height:100%;text-align:center;font-family:Calibri;font-size: 11pt">
						&nbsp;</p>
				</td>
				<td valign="top" style="width:18.00pt;background-color: #auto;padding:0pt 6.5pt">
					<p style="margin:0pt;line-height:120%;font-family:Calibri;font-size: 11pt">
						&nbsp;</p>
				</td>
				<td valign="top" style="width:99.00pt;background-color: #auto;padding:0pt 6.5pt">
					<p style="margin:0pt;line-height:120%;text-align:center;font-family:Calibri;font-size: 11pt">
						&nbsp;</p>
				</td>
			</tr>
			<tr>
				<td valign="top" style="width:193.50pt;background-color: #auto;padding:0pt 6.5pt">
					<p style="margin:0pt;line-height:120%;text-align:center;border-bottom:1pt solid #000000 ;font-family:Calibri;font-size: 10pt">
						<font style="display: inline;font-family:Times New Roman;font-size:10pt;">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;/s/ </font><font style="display: inline;font-family:Times New Roman;font-size:10pt;">Robert Z. Gussin, PhD</font><font style="display: inline;font-family:Times New Roman;font-size:10pt;">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</font><br /><font style="display: inline;font-family:Times New Roman;font-size:10pt;"></font><font style="display: inline;font-family:Times New Roman;font-size:10pt;"> &nbsp;&nbsp; </font><font style="display: inline;font-family:Times New Roman;font-size:10pt;">Robert Z. Gussin, PhD</font></p>
				</td>
				<td valign="top" style="width:18.00pt;background-color: #auto;padding:0pt 6.5pt">
					<p style="margin:0pt;line-height:120%;font-family:Calibri;font-size: 11pt">
						&nbsp;</p>
				</td>
				<td valign="top" style="width:144.00pt;background-color: #auto;padding:0pt 6.5pt">
					<p style="margin:0pt;line-height:100%;text-align:center;font-family:Calibri;font-size: 10pt">
						<font style="display: inline;font-family:Times New Roman;font-size:10pt;">Director</font></p>
				</td>
				<td valign="top" style="width:18.00pt;background-color: #auto;padding:0pt 6.5pt">
					<p style="margin:0pt;line-height:120%;font-family:Calibri;font-size: 11pt">
						&nbsp;</p>
				</td>
				<td valign="top" style="width:99.00pt;background-color: #auto;padding:0pt 6.5pt">
					<p style="margin:0pt;line-height:120%;text-align:center;font-family:Calibri;font-size: 10pt">
						<font style="display: inline;font-family:Times New Roman;font-size:10pt;">June 10, 2022</font></p>
				</td>
			</tr>
			<tr>
				<td valign="top" style="width:193.50pt;background-color: #auto;padding:0pt 6.5pt">
					<p style="margin:0pt;line-height:120%;text-align:center;font-family:Calibri;font-size: 10pt">
						<font style="display: inline;font-family:Times New Roman;font-size:10pt;">&#xFEFF;</font></p>
				</td>
				<td valign="top" style="width:18.00pt;background-color: #auto;padding:0pt 6.5pt">
					<p style="margin:0pt;line-height:120%;font-family:Calibri;font-size: 11pt">
						&nbsp;</p>
				</td>
				<td valign="top" style="width:144.00pt;background-color: #auto;padding:0pt 6.5pt">
					<p style="margin:0pt;line-height:120%;text-align:center;font-family:Calibri;font-size: 11pt">
						&nbsp;</p>
				</td>
				<td valign="top" style="width:18.00pt;background-color: #auto;padding:0pt 6.5pt">
					<p style="margin:0pt;line-height:120%;font-family:Calibri;font-size: 11pt">
						&nbsp;</p>
				</td>
				<td valign="top" style="width:99.00pt;background-color: #auto;padding:0pt 6.5pt">
					<p style="margin:0pt;line-height:120%;text-align:center;font-family:Calibri;font-size: 11pt">
						&nbsp;</p>
				</td>
			</tr>
			<tr>
				<td valign="top" style="width:193.50pt;background-color: #auto;padding:0pt 6.5pt">
					<p style="margin:0pt;line-height:120%;text-align:center;border-bottom:1pt solid #000000 ;font-family:Calibri;font-size: 10pt">
						<font style="display: inline;font-family:Times New Roman;font-size:10pt;">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;/s/ </font><font style="display: inline;font-family:Times New Roman;font-size:10pt;">Michael J. O&#x2019;Donnell Esq.</font><font style="display: inline;font-family:Times New Roman;font-size:10pt;">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</font><br /><font style="display: inline;font-family:Times New Roman;font-size:10pt;"> &nbsp;&nbsp; </font><font style="display: inline;font-family:Times New Roman;font-size:10pt;">Michael J. O&#x2019;Donnell Esq.</font></p>
				</td>
				<td valign="top" style="width:18.00pt;background-color: #auto;padding:0pt 6.5pt">
					<p style="margin:0pt;line-height:120%;font-family:Calibri;font-size: 11pt">
						&nbsp;</p>
				</td>
				<td valign="top" style="width:144.00pt;background-color: #auto;padding:0pt 6.5pt">
					<p style="margin:0pt;line-height:120%;text-align:center;font-family:Calibri;font-size: 10pt">
						<font style="display: inline;font-family:Times New Roman;font-size:10pt;">Director</font></p>
				</td>
				<td valign="top" style="width:18.00pt;background-color: #auto;padding:0pt 6.5pt">
					<p style="margin:0pt;line-height:120%;font-family:Calibri;font-size: 11pt">
						&nbsp;</p>
				</td>
				<td valign="top" style="width:99.00pt;background-color: #auto;padding:0pt 6.5pt">
					<p style="margin:0pt;line-height:120%;text-align:center;font-family:Calibri;font-size: 10pt">
						<font style="display: inline;font-family:Times New Roman;font-size:10pt;">June 10, 2022</font></p>
				</td>
			</tr>
		</table></div>
		<p style="margin:0pt 0pt 10pt;line-height:115%;font-family:Calibri;font-size: 11pt">
			<font style="display: inline;">&#xFEFF;</font>
		</p>
		<p><font size="1"> </font></p><hr size="3" style="color:#999999" width="100%" align="center"></hr><p style="page-break-after:always">&nbsp;</p>
		<div style="width:100%"><table cellpadding="0" cellspacing="0" style="border-collapse:collapse;width:472.50pt;margin-left:18pt;">
			<tr>
				<td valign="top" style="width:193.50pt;border-bottom:1pt solid #000000 ;background-color: #auto;padding:0pt 6.5pt">
					<p style="margin:0pt;line-height:120%;text-align:center;font-family:Calibri;font-size: 10pt">
						<font style="display: inline;font-family:Times New Roman;font-weight:bold;font-size:10pt;">Name</font></p>
				</td>
				<td valign="top" style="width:18.00pt;background-color: #auto;padding:0pt 6.5pt">
					<p style="margin:0pt;line-height:120%;font-family:Calibri;font-size: 11pt">
						&nbsp;</p>
				</td>
				<td valign="top" style="width:144.00pt;border-bottom:1pt solid #000000 ;background-color: #auto;padding:0pt 6.5pt">
					<p style="margin:0pt;line-height:120%;text-align:center;font-family:Calibri;font-size: 10pt">
						<font style="display: inline;font-family:Times New Roman;font-weight:bold;font-size:10pt;">Title</font></p>
				</td>
				<td valign="top" style="width:18.00pt;background-color: #auto;padding:0pt 6.5pt">
					<p style="margin:0pt;line-height:120%;font-family:Calibri;font-size: 11pt">
						&nbsp;</p>
				</td>
				<td valign="top" style="width:99.00pt;border-bottom:1pt solid #000000 ;background-color: #auto;padding:0pt 6.5pt">
					<p style="margin:0pt;line-height:120%;text-align:center;font-family:Calibri;font-size: 10pt">
						<font style="display: inline;font-family:Times New Roman;font-weight:bold;font-size:10pt;">Date</font></p>
				</td>
			</tr>
			<tr>
				<td valign="top" style="width:193.50pt;border-top:1pt solid #000000 ;background-color: #auto;padding:0pt 6.5pt">
					<p style="margin:0pt;line-height:120%;text-align:center;border-bottom:1pt solid #000000 ;font-family:Calibri;font-size: 10pt">
						<font style="display: inline;font-family:Times New Roman;font-size:10pt;">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;/s/ </font><font style="display: inline;font-family:Times New Roman;font-size:10pt;">Patrick Scannon MD, PhD</font><font style="display: inline;font-family:Times New Roman;font-size:10pt;">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</font><br /><font style="display: inline;font-family:Times New Roman;font-size:10pt;"> &nbsp; </font><font style="display: inline;font-family:Times New Roman;font-size:10pt;">Patrick Scannon, MD, PhD</font></p>
				</td>
				<td valign="top" style="width:18.00pt;background-color: #auto;padding:0pt 6.5pt">
					<p style="margin:0pt;line-height:120%;font-family:Calibri;font-size: 11pt">
						&nbsp;</p>
				</td>
				<td valign="top" style="width:144.00pt;border-top:1pt solid #000000 ;background-color: #auto;padding:0pt 6.5pt">
					<p style="margin:0pt;line-height:120%;text-align:center;font-family:Calibri;font-size: 10pt">
						<font style="display: inline;font-family:Times New Roman;font-size:10pt;">Director</font></p>
				</td>
				<td valign="top" style="width:18.00pt;background-color: #auto;padding:0pt 6.5pt">
					<p style="margin:0pt;line-height:120%;font-family:Calibri;font-size: 11pt">
						&nbsp;</p>
				</td>
				<td valign="top" style="width:99.00pt;border-top:1pt solid #000000 ;background-color: #auto;padding:0pt 6.5pt">
					<p style="margin:0pt;line-height:120%;text-align:center;font-family:Calibri;font-size: 10pt">
						<font style="display: inline;font-family:Times New Roman;font-size:10pt;">June 10, 2022</font></p>
				</td>
			</tr>
			<tr>
				<td valign="top" style="width:193.50pt;background-color: #auto;padding:0pt 6.5pt">
					<p style="margin:0pt;line-height:120%;text-align:center;font-family:Calibri;font-size: 10pt">
						<font style="display: inline;font-family:Times New Roman;font-size:10pt;">&#xFEFF;</font></p>
				</td>
				<td valign="top" style="width:18.00pt;background-color: #auto;padding:0pt 6.5pt">
					<p style="margin:0pt;line-height:120%;font-family:Calibri;font-size: 11pt">
						&nbsp;</p>
				</td>
				<td valign="top" style="width:144.00pt;background-color: #auto;padding:0pt 6.5pt">
					<p style="margin:0pt;line-height:120%;text-align:center;font-family:Calibri;font-size: 11pt">
						&nbsp;</p>
				</td>
				<td valign="top" style="width:18.00pt;background-color: #auto;padding:0pt 6.5pt">
					<p style="margin:0pt;line-height:120%;font-family:Calibri;font-size: 11pt">
						&nbsp;</p>
				</td>
				<td valign="top" style="width:99.00pt;background-color: #auto;padding:0pt 6.5pt">
					<p style="margin:0pt;line-height:120%;text-align:center;font-family:Calibri;font-size: 11pt">
						&nbsp;</p>
				</td>
			</tr>
			<tr>
				<td valign="top" style="width:193.50pt;background-color: #auto;padding:0pt 6.5pt">
					<p style="margin:0pt;line-height:120%;text-align:center;font-family:Calibri;font-size: 10pt">
						<font style="display: inline;font-family:Times New Roman;font-size:10pt;">&#xFEFF;</font></p>
				</td>
				<td valign="top" style="width:18.00pt;background-color: #auto;padding:0pt 6.5pt">
					<p style="margin:0pt;line-height:120%;font-family:Calibri;font-size: 11pt">
						&nbsp;</p>
				</td>
				<td valign="top" style="width:144.00pt;background-color: #auto;padding:0pt 6.5pt">
					<p style="margin:0pt;line-height:120%;text-align:center;font-family:Calibri;font-size: 11pt">
						&nbsp;</p>
				</td>
				<td valign="top" style="width:18.00pt;background-color: #auto;padding:0pt 6.5pt">
					<p style="margin:0pt;line-height:120%;font-family:Calibri;font-size: 11pt">
						&nbsp;</p>
				</td>
				<td valign="top" style="width:99.00pt;background-color: #auto;padding:0pt 6.5pt">
					<p style="margin:0pt;line-height:120%;text-align:center;font-family:Calibri;font-size: 11pt">
						&nbsp;</p>
				</td>
			</tr>
			<tr>
				<td valign="top" style="width:193.50pt;background-color: #auto;padding:0pt 6.5pt">
					<p style="margin:0pt;line-height:120%;text-align:center;font-family:Calibri;font-size: 10pt">
						<font style="display: inline;font-family:Times New Roman;font-size:10pt;">&#xFEFF;</font><a name="_Hlk79480590"></a></p>
				</td>
				<td valign="top" style="width:18.00pt;background-color: #auto;padding:0pt 6.5pt">
					<p style="margin:0pt;line-height:120%;font-family:Calibri;font-size: 11pt">
						&nbsp;</p>
				</td>
				<td valign="top" style="width:144.00pt;background-color: #auto;padding:0pt 6.5pt">
					<p style="margin:0pt;line-height:120%;text-align:center;font-family:Calibri;font-size: 11pt">
						&nbsp;</p>
				</td>
				<td valign="top" style="width:18.00pt;background-color: #auto;padding:0pt 6.5pt">
					<p style="margin:0pt;line-height:120%;font-family:Calibri;font-size: 11pt">
						&nbsp;</p>
				</td>
				<td valign="top" style="width:99.00pt;background-color: #auto;padding:0pt 6.5pt">
					<p style="margin:0pt;line-height:120%;text-align:center;font-family:Calibri;font-size: 11pt">
						&nbsp;</p>
				</td>
			</tr>
			<tr>
				<td valign="top" style="width:193.50pt;background-color: #auto;padding:0pt 6.5pt">
					<p style="margin:0pt;line-height:120%;text-align:center;font-family:Calibri;font-size: 10pt">
						<font style="display: inline;font-family:Times New Roman;font-size:10pt;text-decoration:underline;">&#xFEFF;</font></p>
				</td>
				<td valign="top" style="width:18.00pt;background-color: #auto;padding:0pt 6.5pt">
					<p style="margin:0pt;line-height:120%;font-family:Calibri;font-size: 11pt">
						&nbsp;</p>
				</td>
				<td valign="top" style="width:144.00pt;background-color: #auto;padding:0pt 6.5pt">
					<p style="margin:0pt;line-height:100%;text-align:center;font-family:Calibri;font-size: 11pt">
						&nbsp;</p>
				</td>
				<td valign="top" style="width:18.00pt;background-color: #auto;padding:0pt 6.5pt">
					<p style="margin:0pt;line-height:120%;font-family:Calibri;font-size: 11pt">
						&nbsp;</p>
				</td>
				<td valign="top" style="width:99.00pt;background-color: #auto;padding:0pt 6.5pt">
					<p style="margin:0pt;line-height:120%;text-align:center;font-family:Calibri;font-size: 11pt">
						&nbsp;</p>
				</td>
			</tr>
			<tr>
				<td valign="top" style="width:193.50pt;background-color: #auto;padding:0pt 6.5pt">
					<p style="margin:0pt;line-height:120%;text-align:center;font-family:Calibri;font-size: 10pt">
						<font style="display: inline;font-family:Times New Roman;font-size:10pt;text-decoration:underline;">&#xFEFF;</font></p>
				</td>
				<td valign="top" style="width:18.00pt;background-color: #auto;padding:0pt 6.5pt">
					<p style="margin:0pt;line-height:120%;font-family:Calibri;font-size: 11pt">
						&nbsp;</p>
				</td>
				<td valign="top" style="width:144.00pt;background-color: #auto;padding:0pt 6.5pt">
					<p style="margin:0pt;line-height:100%;text-align:center;font-family:Calibri;font-size: 11pt">
						&nbsp;</p>
				</td>
				<td valign="top" style="width:18.00pt;background-color: #auto;padding:0pt 6.5pt">
					<p style="margin:0pt;line-height:120%;font-family:Calibri;font-size: 11pt">
						&nbsp;</p>
				</td>
				<td valign="top" style="width:99.00pt;background-color: #auto;padding:0pt 6.5pt">
					<p style="margin:0pt;line-height:120%;text-align:center;font-family:Calibri;font-size: 11pt">
						&nbsp;</p>
				</td>
			</tr>
		</table></div>
		<p style="margin:0pt 0pt 10pt;line-height:115%;font-family:Calibri;font-size: 11pt">
			<font style="display: inline;">&#xFEFF;</font>
		</p>
		<p style="margin:0pt;line-height:normal;font-family:Calibri;font-size: 10pt">
			<font style="display: inline;font-family:Times New Roman;font-size:10pt;">&#xFEFF;</font>
		</p>
		<p style="margin:0pt;line-height:normal;font-family:Calibri;font-size: 10pt">
			<font style="display: inline;font-family:Times New Roman;font-size:10pt;">&#xFEFF;</font>
		</p>
		<p style="margin:0pt;line-height:normal;font-family:Calibri;font-size: 11pt">
			<font style="display: inline;">&#xFEFF;</font>
		</p>
		<p><font size="1"> </font></p><hr size="3" style="color:#999999" width="100%" align="center"></hr>
	</div></body>
</html>
[{"type": "S-8", "sequence": "1", "filename": "sava-20220610xs8.htm", "description": "S-8", "secsgml_size_bytes": 111308}]
{"company-data": {"conformed-name": "CASSAVA SCIENCES INC", "cik": "0001069530", "assigned-sic": "2834", "irs-number": "911911336", "state-of-incorporation": "DE", "fiscal-year-end": "1231"}, "filing-values": {"form-type": "S-8", "act": "33", "file-number": "333-265540", "film-number": "221009937"}, "business-address": {"street1": "7801 N CAPITAL OF TEXAS HIGHWAY", "street2": "SUITE 260", "city": "AUSTIN", "state": "TX", "zip": "78731", "phone": "512-501-2444"}, "mail-address": {"street1": "7801 N CAPITAL OF TEXAS HIGHWAY", "street2": "SUITE 260", "city": "AUSTIN", "state": "TX", "zip": "78731"}, "former-company": {"former-conformed-name": "PAIN THERAPEUTICS INC", "date-changed": "20000309"}}
Cassava Sciences Form S-8 (2018 Plan Increase)
As filed with the Securities and Exchange
Commission on
June 10, 2022
﻿
Registration No. 333
-
UNITED STATES
SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM S-8
REGISTRATION STATEMENT UNDER THE SECURITIES ACT OF 1933
CASSAVA SCIENCES
, INC.
(Exact Name of Registrant as Specified in Its Charter)
Delaware
9
1
-
1911336
(State or Other Jurisdiction of
(I.R.S. Employer
Incorporation or Organization)
Identification
No.
)
7801 N Capital of Texas Highway, Suite 260
Austin, Texas 78731
(Address of Principal Executive Offices) (Zip Code)
2018 Omnibus Incentive Plan
(Full Title of the Plan)
Remi Barbier
Chairman of the Board of Directors,
President and Chief Executive Officer
Cassava Sciences
, Inc.
7801 N Capital of Texas Highway, Suite 260
Austin, Texas 78731
(Name and Address of Agent for Service)
(512) 501-2444
(Telephone Number, Including Area Code, of Agent for Service)
Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer
,
a smaller reporting company
or an
emerging growth company
.  See the definitions of "large accelerated filer", "accelerated filer
,
" "smaller reporting company"
and
"
emerging growth company
"
in Rule 12b-2 of the Exchange Act.
﻿
Large accelerated filer
☒
Accelerated filer
☐
﻿
Non-accelerated filer
☐
Smaller reporting company
☐
﻿
Emerging growth
company
☐
﻿
If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 7(a)(2)(B) of the Securities Act.
☐
EXPLANATORY NOTE
﻿
A Registration Statement on Form S-8 was filed with the Securities and Exchange Commission (the "Commission") on June 19, 2018 (File No. 333-225708) covering the registration of 1,000,000 shares of Common Stock, par value $0.001 per share, of Cassava Sciences, Inc. (the
"Registrant
")
authorized for issuance
under the 2018 Omnibus Incentive Plan (the "Plan").
T
his Registration Statement on Form S-8 is being filed to register an additional 4,000,000 shares of Common Stock
that were added to the shares authorized for issuance under the Plan pursuant to Amendment No. 1 to the Plan, which was approved by the Registrant's stockholders on May 5, 2022, the date of the Registrant's 2022 Annual Meeting
.
﻿
PART I
INFORMATION REQUIRED IN THE SECTION 10(A) PROSPECTUS
The documents containing the information specified in this Part I will be delivered to the participants in the
Plan
as required by Rule 428(b)(1) of the Securities Act. Such documents are not required to be filed with the Commission as part of this Registration Statement.
﻿
PART II
INFORMATION REQUIRED IN THE REGISTRATION STATEMENT
Item 3.
Incorporation of Documents by Reference
.
The following documents, which have been filed by the Registrant with the Commission, are hereby incorporated by reference in this Registration Statement
:
(a)
The Registrant's Annual Report on Form 10-K
(
the "Annual Report"
)
for the fis
cal year ended
December
31,
20
2
1
, filed with the
Commi
s
sion
on
March
1
,
20
2
2
;
(b)
All other reports filed pursuant to Section 13(a) or 15(d) of the Securities
Exchange Act of 1934, as amended (the "Exchange Act"), since the end of the fiscal year covered by the
Annual Report
referred to in (a) above; and
(c)
The
description of Common Stock contained in
Exhibit 4.2
of
the
Registrant's
Annual Report for the fiscal year ended December 31, 2019
, filed with the
Commission
on
March
26
,
20
2
0
.
All documents subsequently filed by the Registrant pursuant to Sections 13(a), 13(c), 14 and 15(d) of the Exchange Act, prior to the filing of a post-effective amendment, which indicates that all securities offered hereby have been sold or which deregisters all securities then remaining unsold, shall be deemed to be incorporated by reference herein and to be a part hereof from the date of the filing of such documents, except as to specific sections of such statements as set forth therein.
Unless expressly incorporated into this Registration Statement, a report furnished on Form 8-K prior or subsequent to the date hereof shall not be incorporated by reference into this Registration Statement, except as to specific sections of such statements as set forth therein. Any statement contained in a document incorporated or deemed to be incorporated by reference herein shall be deemed to be modified or superseded for purposes of this Registration Statement to the extent that a statement contained in any subsequently filed document, which also is deemed to be incorporated by reference herein, modifies or supersedes such statement.
﻿
Item 4.
Description of Securities
.
Not applicable.
Item 5.
Interests of Named Experts and Counsel
.
Not applicable.
Item 6.
Indemnification of Directors and Officers
.
The Delaware General Corporation Law (the "DGCL") authorizes corporations to limit or eliminate the personal liability of directors to corporations and their stockholders for monetary damages for breaches of directors' fiduciary duties as directors, and our amended and restated certificate of incorporation includes such an exculpation provision. Under the provisions of our amended and restated certificate of incorporation and bylaws, each person
who is or was one of our directors or officers shall be indemnified by us as of right to the full extent permitted by the DGCL.
Under the DGCL, to the extent that a person is successful on the merits in defense of a suit or proceeding brought against him or her because that person is or was one of our directors or officers, he or she shall be indemnified against expenses (including attorneys' fees) actually and reasonably incurred in connection with such action. If unsuccessful in defense of a third-party civil suit or a criminal suit, or if such a suit is settled, that person shall be indemnified against both (i) expenses, including attorneys' fees, and (ii) judgments, fines and amounts paid in settlement if he or she acted in good faith and in a manner he or she reasonably believed to be in, or not opposed to, our best interests and, with respect to any criminal action, had no reasonable cause to believe his or her conduct was unlawful. If unsuccessful in defense of a suit brought by or in our right, or if such suit is settled, that person shall be indemnified only against expenses, including attorneys' fees, incurred in the defense or settlement of the suit if he or she acted in good faith and in a manner he or she  reasonably believed to be in, or not opposed to, our best interests, except that
no indemnification shall be made in respect of any claim, issue or matter as to which such person shall have been adjudged to be liable to the corporation unless and only to the extent that the Court of Chancery or the court in which such action or suit was brought shall determine upon application that, despite the adjudication of liability but in view of all circumstances of the case, such person is fairly and reasonably entitled to indemnity for such expenses which the Court of Chancery or such other court shall deem proper
.
Under our amended and restated certificate of incorporation and bylaws, the right to indemnification includes the right to be paid by us the expenses incurred in defending any action, suit or proceeding in advance of its final disposition, subject to the receipt by us of undertakings as may be legally defined. In any action by an indemnitee to enforce a right to indemnification or by us to recover advances made, the burden of proving that the indemnitee is not entitled to be indemnified is placed on us.
The
Registrant
has entered into indemnification agreements with its current directors and officers. The indemnification agreements supplement the indemnification provisions applicable under our amended and restated certificate of incorporation and bylaws, and the DGCL.
Among the terms and conditions of the indemnification agreements are provisions providing for director and officer indemnitees to be indemnified in the context of certain third-party proceedings and proceedings by or in the right of the
Registrant
. The agreements also provide for, under certain circumstances, indemnification against certain expenses to the extent an indemnitee is wholly or partly successful in a proceeding, and to the extent an indemnitee is a witness or otherwise asked to participate in a proceeding to which the indemnitee is not a party. Also, under certain conditions, the indemnification agreements provide for the advancement of certain expenses from the
Registrant
to an indemnitee.
We maintain liability insurance for our directors and officers to provide protection where we cannot legally indemnify a director or officer and where a claim arises under the Employee Retirement Income Security Act of 1974 against a director or officer based on an alleged breach of fiduciary duty or other wrongful act and directors' and officers' liability insurance for our directors and officers.
The foregoing is only a general summary of certain aspects of Delaware law and our amended and restated certificate of incorporation and bylaws dealing with indemnification of directors and officers and does not purport to be complete. It is qualified in its entirety by reference to the detailed provisions of those sections of the DGCL referenced above and our amended and restated certificate of incorporation and bylaws.
Item 7.
Exemption From Registration Claimed
.
Not applicable.
Item 8.
Exhibits
.
﻿
Exhibit Number
Description of Exhibit
﻿
5.1
*
Opinion and Consent of Orrick, Herrington & Sutcliffe LLP
﻿
23.1
*
Consent of Independent Registered Public Accounting Firm
﻿
23.2
Consent of Orrick, Herrington & Sutcliffe LLP (included in Exhibit 5.1 to this Registration Statement)
﻿
24.1
Power of Attorney (filed as part of signature page).
99.1
Cassava Sciences, Inc. 2018 Omnibus Incentive Plan, as amended
(incorporated herein by reference to
Appendix A
and
Appendix B
to Registrant's Definitive Proxy Statement on Schedule 14A filed on
March 24, 2022
)
﻿
107
*
Filing Fee Table
﻿
*
Filed herewith.
﻿
Item 9.
Undertakings
.
(a) The undersigned Registrant hereby undertakes:
(1) To file, during any period in which offers or sales are being made, a post-effective amendment to this Registration Statement:
(i) To include any prospectus required by Section 10(a)(3) of the Securities Act;
(ii) To reflect in the prospectus any facts or events arising after the effective date of the
R
egistration
S
tatement (or the most recent post-effective amendment thereof) which, individually or in the aggregate, represent a fundamental change in the information set forth in the
R
egistration
S
tatement
; and
(iii) To include any material information with respect to the plan of distribution not previously disclosed in the
R
egistration
S
tatement or any material change to such information in the
R
egistration
S
tatement;
provided, however
,
that paragraphs (a)(1)(i) and (a)(1)(ii) of this section do not apply if the information required to be included in a post-effective amendment by those paragraphs is contained in reports filed with or furnished to the Commission by the Registrant pursuant to Section 13 or Section 15(d) of the Exchange Act that are incorporated by reference in the
R
egistration
S
tatement.
(2) That, for the purpose of determining any liability under the Securities Act, each such post-effective amendment shall be deemed to be a new
R
egistration
S
tatement relating to the securities offered therein, and the offering of such securities at that time shall be deemed to be the initial bona fide offering thereof.
(3) To remove from registration by means of a post-effective amendment any of the securities being registered which remain unsold at the termination of the offering.
(b)
The Registrant hereby undertakes that, for purposes of determining any liability under the Securities Act, each filing of the Registrant's annual report pursuant to Section 13(a) or Section 15(d) of the Exchange Act that is incorporated by reference in the Registration Statement shall be deemed to be a new Registration Statement relating to the securities offered therein, and the offering of such securities at that time shall be deemed to be the initial bona fide offering thereof.
(c)
Insofar as indemnification for liabilities arising under the Securities Act may be permitted to directors, officers and controlling persons of the Registrant pursuant to the foregoing provisions, or otherwise, the Registrant has been advised that in the opinion of the Commission such indemnification is against public policy as expressed in the Securities Act and is, therefore, unenforceable. In the event that a claim for indemnification against such liabilities (other than the payment by the Registrant of expenses incurred or paid by a director, officer or controlling person of the Registrant in the successful defense of any action, suit or proceeding) is asserted by such director, officer or controlling person in connection with the securities being registered, the Registrant will, unless in the opinion of its counsel the matter has been settled by controlling precedent, submit to a court of appropriate jurisdiction the question whether such indemnification by it is against public policy as expressed in the Securities Act and will be governed by the final adjudication of such issue.
SIGNATURES
Pursuant to the requirements of the Securities Act, the Registrant certifies that it has reasonable grounds to believe that it meets all of the requirements for filing on Form S-8 and has duly caused this Registration Statement to be signed on its behalf by the undersigned, thereunto duly authorized, in the City of
Austin
, State of
Texas
, on
June 10, 2022
.
﻿
Cassava Sciences, Inc
.
﻿
﻿
By:
/s/ Remi Barbier
﻿
Remi Barbier
﻿
Chairman of the Board of Directors, President and Chief Executive Officer
POWER OF ATTORN
EY
KNOW ALL PERSONS BY THESE PRESENTS, that each person whose signature appears below hereby constitutes and appoints, jointly and severally,
Remi Barbier
and Eric J. Schoen
as his or her true and lawful attorney-in-fact and agent, with full power of substitution and revocation, in his or her name and on his or her behalf, in any and all capacities, to sign any or all amendments (including post-effective amendments) to this Registration Statement, and to file the same, with all exhibits thereto, and other documents in connection therewith, with the Commission, granting unto said attorneys-in-fact and agents full power and authority to do and perform each and every act and thing requisite and necessary to be done in and about the premises, as fully for all intents and purposes as he or she might or could do in person, hereby ratifying and confirming all that said attorneys-in-fact and agents, or their substitutes, may lawfully do or cause to be done by virtue hereof.
Pursuant to the requirements of the Securities Act, this Registration Statement has been signed by the following persons in the capacities and on the dates indicated.
n
Name
Title
Date
﻿
/s/
Remi Barbier
Remi Barbier
Chairman of the Board of Directors,
President and Chief Executive
Officer
(Principal Executive Officer)
June 10, 2022
﻿
/s/
Eric Schoen
Eric Schoen
Chief Financial Officer
(Principal Financial Officer)
June 10, 2022
﻿
/s/
Nadav Friedmann, PhD, MD
Nadav Friedmann, PhD, MD
Chief Medical Officer and Director
June 10, 2022
﻿
/s/
Sanford R. Robertson
Sanford R. Robertson
Director
June 10, 2022
﻿
/s/
Richard J. Barry
Richard J. Barry
Director
June 10, 2022
﻿
/s/
Robert Z. Gussin, PhD
Robert Z. Gussin, PhD
Director
June 10, 2022
﻿
/s/
Michael J. O'Donnell Esq.
Michael J. O'Donnell Esq.
Director
June 10, 2022
﻿
Name
Title
Date
/s/
Patrick Scannon MD, PhD
Patrick Scannon, MD, PhD
Director
June 10, 2022
﻿
﻿
﻿
﻿
﻿
﻿
﻿
﻿
﻿