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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center"><B>As filed with the Securities and Exchange
Commission on August 14, 2020</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0 0 0 4.5in; text-align: right"><B>Registration No. 333-</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>

<P STYLE="font: 12pt Times New Roman, Times, Serif; margin: 0; text-align: center"><B>UNITED STATES</B></P>

<P STYLE="font: 12pt Times New Roman, Times, Serif; margin: 0; text-align: center"><B>SECURITIES AND EXCHANGE COMMISSION</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center"><B>Washington, D.C. 20549</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>

<P STYLE="font: 12pt Times New Roman, Times, Serif; margin: 0; text-align: center"><B>FORM S-8</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>

<P STYLE="font: 12pt Times New Roman, Times, Serif; margin: 0; text-align: center"><B>REGISTRATION STATEMENT</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center"><B>UNDER</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center"><B>THE SECURITIES ACT OF 1933</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>

<P STYLE="font: 18pt Times New Roman, Times, Serif; margin: 0; text-align: center"><B>OPGEN, INC.</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center">(Exact name of registrant as specified in its
charter)</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="width: 100%; border-collapse: collapse">
<TR>
    <TD COLSPAN="2" STYLE="font: 12pt Times New Roman, Times, Serif; text-align: center"><FONT STYLE="font-size: 10pt"><B>Delaware</B></FONT></TD>
    <TD COLSPAN="2" STYLE="font: 12pt Times New Roman, Times, Serif; text-align: center"><FONT STYLE="font-size: 10pt"><B>06-1614015</B></FONT></TD></TR>
<TR>
    <TD COLSPAN="2" STYLE="font: 12pt Times New Roman, Times, Serif; text-align: center"><FONT STYLE="font-size: 10pt">(State or other jurisdiction of&nbsp;incorporation or organization)</FONT></TD>
    <TD COLSPAN="2" STYLE="font: 12pt Times New Roman, Times, Serif; text-align: center"><FONT STYLE="font-size: 10pt">(I.R.S. Employer Identification No.)</FONT></TD></TR>
<TR>
    <TD COLSPAN="2" STYLE="font: 12pt Times New Roman, Times, Serif; text-align: center">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="font: 12pt Times New Roman, Times, Serif; text-align: center">&nbsp;</TD></TR>
<TR>
    <TD STYLE="font: 12pt Times New Roman, Times, Serif">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="font: 12pt Times New Roman, Times, Serif; text-align: center"><FONT STYLE="font-size: 10pt"><B>708 Quince Orchard Road<BR>
Gaithersburg, MD 20878</B></FONT></TD>
    <TD STYLE="font: 12pt Times New Roman, Times, Serif">&nbsp;</TD></TR>
<TR>
    <TD STYLE="font: 12pt Times New Roman, Times, Serif">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="font: 12pt Times New Roman, Times, Serif; text-align: center"><FONT STYLE="font-size: 10pt">(Address of Principal Executive Offices)(Zip Code)</FONT></TD>
    <TD STYLE="font: 12pt Times New Roman, Times, Serif">&nbsp;</TD></TR>
<TR>
    <TD STYLE="width: 30%">&nbsp;</TD>
    <TD STYLE="width: 20%">&nbsp;</TD>
    <TD STYLE="width: 20%">&nbsp;</TD>
    <TD STYLE="width: 30%">&nbsp;</TD></TR>
</TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center"><B>AMENDED AND RESTATED STOCK OPTION PLAN </B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center">(Full title of the plan)</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center"><B>Timothy C. Dec</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center"><B>Chief Financial Officer</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center"><B>708 Quince Orchard Road</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center"><B>Gaithersburg, MD 20878</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center">(Name and address of agent for service)</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center"><B>(240) 813-1260</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center">(Telephone number, including area code, of agent
for service)</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center">with a copy to:</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center"><B>Peter Jaslow, Esquire</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center"><B>Ballard Spahr LLP</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center"><B>1735 Market Street</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center"><B>51st Floor</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center"><B>Philadelphia, PA 19103</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center"><B>215-665-8500</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify">Indicate by check mark whether the registrant
is a large accelerated filer, an accelerated filer, a non-accelerated filer, or a smaller reporting company.&nbsp;&nbsp;See the
definitions of &ldquo;large accelerated filer,&rdquo; &ldquo;accelerated filer,&rdquo; &ldquo;smaller reporting company,&rdquo;
and &ldquo;emerging growth company&rdquo; in Rule 12b-2 of the Exchange Act.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="width: 100%; font: 12pt Times New Roman, Times, Serif; border-collapse: collapse">
<TR STYLE="vertical-align: top">
    <TD STYLE="width: 50%; padding-right: 5.4pt; padding-left: 5.4pt"><FONT STYLE="font-size: 10pt">Large Accelerated Filer </FONT>[_]</TD>
    <TD STYLE="width: 50%; padding-right: 5.4pt; padding-left: 5.4pt"><FONT STYLE="font-size: 10pt">Accelerated Filer </FONT>[_]</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-right: 5.4pt; padding-left: 5.4pt"><FONT STYLE="font-size: 10pt">Non-Accelerated Filer &nbsp;</FONT>[_]</TD>
    <TD STYLE="padding-right: 5.4pt; padding-left: 5.4pt"><FONT STYLE="font-size: 10pt">Smaller Reporting Company </FONT>[X]</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-right: 5.4pt; padding-left: 5.4pt">&nbsp;</TD>
    <TD STYLE="padding-right: 5.4pt; padding-left: 5.4pt"><FONT STYLE="font-size: 10pt">Emerging Growth Company </FONT>[X]</TD></TR>
</TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">If an emerging growth company, indicate by check mark if the registrant
has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided
to Section 7(a)(2)(B) of the Securities Act. [_]</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>


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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center"><B>CALCULATION OF REGISTRATION FEE</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="border-collapse: collapse; width: 100%; font: 10pt Times New Roman, Times, Serif">
<TR STYLE="vertical-align: bottom">
    <TD STYLE="border-bottom: Black 1pt solid">Title of Securities to be Registered</TD><TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
    <TD COLSPAN="3" STYLE="text-align: center; border-bottom: Black 1pt solid">Number of Shares to be Registered(1)</TD><TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
    <TD COLSPAN="3" STYLE="text-align: center; border-bottom: Black 1pt solid">Proposed Maximum Offering Price Per Share</TD><TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
    <TD COLSPAN="4" STYLE="text-align: center; border-bottom: Black 1pt solid">Proposed Maximum Aggregate Offering Price</TD><TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
    <TD COLSPAN="4" STYLE="text-align: center; border-bottom: Black 1pt solid">Amount of Registration Fee</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: rgb(204,238,255)">
    <TD STYLE="vertical-align: bottom; width: 41%; text-align: left">Common Stock, par value $0.01 per share, reserved for issuance pursuant to the Amended and Restated Stock Option Plan, as assumed and adopted as of April 1, 2020</TD><TD STYLE="width: 2%">&nbsp;</TD>
    <TD STYLE="width: 1%; text-align: left">&nbsp;</TD><TD STYLE="width: 11%; text-align: right"><FONT STYLE="font-size: 10pt">134,371 (2)</FONT></TD><TD STYLE="width: 1%; text-align: left">&nbsp;</TD><TD STYLE="width: 1%">&nbsp;</TD>
    <TD STYLE="width: 1%; text-align: left">$</TD><TD STYLE="width: 11%; text-align: right">2.35&nbsp;(3)</TD><TD STYLE="width: 1%; text-align: left">&nbsp;</TD><TD STYLE="width: 1%">&nbsp;</TD>
    <TD STYLE="width: 1%">&nbsp;</TD>
    <TD STYLE="width: 1%; text-align: left">$</TD><TD STYLE="width: 11%; text-align: right">315,771.85</TD><TD STYLE="width: 1%; text-align: left">&nbsp;</TD><TD STYLE="width: 1%">&nbsp;</TD>
    <TD STYLE="width: 1%">&nbsp;</TD>
    <TD STYLE="width: 1%; text-align: left">$</TD><TD STYLE="width: 11%; text-align: right">40.99</TD><TD STYLE="width: 1%; text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: White">
    <TD STYLE="font-size: 12pt">&nbsp;</TD><TD STYLE="font-size: 12pt">&nbsp;</TD>
    <TD STYLE="font-size: 12pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 12pt; text-align: right">&nbsp;</TD><TD STYLE="font-size: 12pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 12pt">&nbsp;</TD>
    <TD STYLE="font-size: 12pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 12pt; text-align: right">&nbsp;</TD><TD STYLE="font-size: 12pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 12pt">&nbsp;</TD>
    <TD STYLE="font-size: 12pt">&nbsp;</TD>
    <TD STYLE="font-size: 12pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 12pt; text-align: right">&nbsp;</TD><TD STYLE="font-size: 12pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 12pt">&nbsp;</TD>
    <TD STYLE="font-size: 12pt">&nbsp;</TD>
    <TD STYLE="font-size: 12pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 12pt; text-align: right">&nbsp;</TD><TD STYLE="font-size: 12pt; text-align: left">&nbsp;</TD></TR>
</TABLE>



<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 0"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0"></TD><TD STYLE="width: 0.5in">(1)</TD><TD>Pursuant to Rule 416(a) promulgated under the Securities Act of 1933, as amended, or the Securities Act, this registration
statement, or this Registration Statement, also covers an indeterminate number of additional shares of common stock issuable under
the Amended and Restated Stock Option Plan, as assumed and adopted as of April 1, 2020 (the &ldquo;Assumed Plan&rdquo;) in the
event the number of outstanding shares of the Registrant is increased by reason of any stock dividend, stock split, recapitalization,
merger, consolidation or reorganization or similar transaction.</TD></TR></TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0 0 0 0.5in; text-indent: -0.5in">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 0"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0"></TD><TD STYLE="width: 0.5in">(2)</TD><TD>Represents 134,371 shares of the Registrant&rsquo;s common stock reserved for issuance under the Assumed Plan.</TD></TR></TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 0"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0"></TD><TD STYLE="width: 0.5in">(3)</TD><TD>Estimated in accordance with Rule 457(h) solely for the purpose of calculating the registration fee on the basis of the average
of the high and low prices reported for the common stock on the NASDAQ Capital Market on August 13, 2020.</TD></TR></TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0 0 0 0.5in; text-indent: -0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>


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<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0; text-align: center">PART I</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0; text-align: center">&nbsp;</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0; text-align: center">INFORMATION REQUIRED IN THE SECTION 10(a)
PROSPECTUS</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-indent: 0.5in">As permitted by the rules of the United States
Securities and Exchange Commission, or the Commission, this Registration Statement omits the information specified in the instructions
to Part I of Form S-8. Documents containing such information will be sent or given to participants in the employee benefit plans,
as defined in Rule 405 under the Securities Act, covered by this Registration Statement as required by Rule 428(b)(1) under the
Securities Act. Those documents are not being filed with the Commission as part of this Registration Statement or as prospectuses
or prospectus supplements pursuant to Rule 424 under the Securities Act. Those documents, and the documents incorporated by reference
in this Registration Statement pursuant to Item 3 of Part II hereof, taken together, constitute a prospectus that meets the requirements
of Section 10(a) of the Securities Act.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center"><B>&nbsp;</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center"><B>PART II</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center"><B>INFORMATION REQUIRED IN THE REGISTRATION
STATEMENT</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0"><B>ITEM 3. INCORPORATION OF DOCUMENTS BY REFERENCE.</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-indent: 0.5in">The following documents, previously filed with
the Commission, are hereby incorporated by reference into this Registration Statement:</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 12pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 12pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.5in"></TD><TD STYLE="width: 0.5in"><FONT STYLE="font-family: Symbol; font-size: 10pt">&#183;</FONT></TD><TD><FONT STYLE="font-size: 10pt">The Registrant&rsquo;s <A HREF="http://www.sec.gov/Archives/edgar/data/1293818/000156459020012253/opgn-10k_20191231.htm" STYLE="-sec-extract: exhibit">Annual Report on Form 10-K</A>, filed with the Commission on March 24, 2020,
for the year ended December 31, 2019, which contains the Registrant&rsquo;s audited financial statements for the latest fiscal
year for which such statements have been filed;</FONT></TD></TR></TABLE>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 12pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 12pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.5in"></TD><TD STYLE="width: 0.5in"><FONT STYLE="font-family: Symbol; font-size: 10pt">&#183;</FONT></TD><TD><FONT STYLE="font-size: 10pt">The Registrant&rsquo;s Quarterly Report on Form 10-Q for the quarters ended<A HREF="http://www.sec.gov/Archives/edgar/data/1293818/000107997320000357/opgen_10q-033120.htm" STYLE="-sec-extract: exhibit"> March 31, 2020</A> and
<A HREF="http://www.sec.gov/Archives/edgar/data/1293818/000107997320000695/opgen_10q-063020.htm" STYLE="-sec-extract: exhibit">June 30, 2020</A>, filed with the Commission on May 8, 2020 and August 14, 2020, respectively;</FONT></TD></TR></TABLE>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 12pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 12pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.5in"></TD><TD STYLE="width: 0.5in"><FONT STYLE="font-family: Symbol; font-size: 10pt">&#183;</FONT></TD><TD><FONT STYLE="font-size: 10pt">The Registrant&rsquo;s Current Reports on Form 8-K, filed with the Commission on <A HREF="http://www.sec.gov/Archives/edgar/data/1293818/000107997320000037/opgn_8k.htm" STYLE="-sec-extract: exhibit">January 23,
2020 (Item 8.01)</A>; <A HREF="http://www.sec.gov/Archives/edgar/data/1293818/000107997320000070/opgen_8k.htm" STYLE="-sec-extract: exhibit">January 30, 2020 (Item 8.01 and 9.01)</A>; <A HREF="http://www.sec.gov/Archives/edgar/data/1293818/000107997320000103/opgen_8k.htm" STYLE="-sec-extract: exhibit">February 12, 2020 (Items 1.01 and 9.01)</A>; <A HREF="http://www.sec.gov/Archives/edgar/data/1293818/000107997320000106/opgen_8k.htm" STYLE="-sec-extract: exhibit">February 12, 2020 (Items 8.01
and 9.01)</A>; <A HREF="http://www.sec.gov/Archives/edgar/data/1293818/000107997320000125/opgen_8k.htm" STYLE="-sec-extract: exhibit">February 20, 2020 (Items 8.01 and 9.01)</A>; <A HREF="http://www.sec.gov/Archives/edgar/data/1293818/000107997320000136/opgen_8k-022820.htm" STYLE="-sec-extract: exhibit">February 28, 2020 (Items 1.01 and 9.01)</A>; <A HREF="http://www.sec.gov/Archives/edgar/data/1293818/000107997320000159/opgn_8k425.htm" STYLE="-sec-extract: exhibit">March 10, 2020 (Items 8.01 and 9.01)</A>;
<A HREF="http://www.sec.gov/Archives/edgar/data/1293818/000107997320000175/opgen_8k.htm" STYLE="-sec-extract: exhibit">March 16, 2020 (Items 8.01 and 9.01)</A>; <A HREF="http://www.sec.gov/Archives/edgar/data/1293818/000107997320000194/opgen_8k-031920.htm" STYLE="-sec-extract: exhibit">March 19, 2020 (Items 8.01 and 9.01)</A>; <A HREF="http://www.sec.gov/Archives/edgar/data/1293818/000107997320000213/ex99x2.htm" STYLE="-sec-extract: exhibit">March 24, 2020 (Items 8.01 and 9.01, but only exhibit
99.2 thereof)</A> <A HREF="http://www.sec.gov/Archives/edgar/data/1293818/000107997320000229/opgen_8k-033020.htm" STYLE="-sec-extract: exhibit">March 30, 2020 (Items 5.07, 8.01 and 9.01)</A>; <A HREF="http://www.sec.gov/Archives/edgar/data/1293818/000107997320000254/opgen_8k.htm" STYLE="-sec-extract: exhibit">April 2, 2020 (Items 2.01, 5.02, 8.01 and 9.01)</A>,<A HREF="http://www.sec.gov/Archives/edgar/data/1293818/000107997320000474/opgn_8k.htm" STYLE="-sec-extract: exhibit"> as amended on June 15,
2020</A>; <A HREF="http://www.sec.gov/Archives/edgar/data/1293818/000107997320000291/opgen_8k.htm" STYLE="-sec-extract: exhibit">April 16, 2020 (Item 8.01)</A>; <A HREF="http://www.sec.gov/Archives/edgar/data/1293818/000107997320000313/opgen_8k.htm" STYLE="-sec-extract: exhibit">April 28, 2020 (Items 1.01, 2.03 and 9.01)</A>; <A HREF="http://www.sec.gov/Archives/edgar/data/1293818/000107997320000352/opgen_8k-050720.htm" STYLE="-sec-extract: exhibit">May 7, 2020 (Item 5.02)</A>; <A HREF="http://www.sec.gov/Archives/edgar/data/1293818/000107997320000374/opgen_8k.htm" STYLE="-sec-extract: exhibit">May 11, 2020 (Items 8.01
and 9.01)</A>; <A HREF="http://www.sec.gov/Archives/edgar/data/1293818/000107997320000474/opgn_8k.htm" STYLE="-sec-extract: exhibit">June 3, 2020 (Items 8.01 and 9.01)</A>; <A HREF="http://www.sec.gov/Archives/edgar/data/1293818/000107997320000586/opgen_8k.htm" STYLE="-sec-extract: exhibit">July 13, 2020 (Items 1.01, 2.03, 8.01 and 9.01)</A>; <A HREF="http://www.sec.gov/Archives/edgar/data/1293818/000107997320000589/opgen_8k.htm" STYLE="-sec-extract: exhibit">July 14, 2020 (Items 8.01 and 9.01)</A>;
<A HREF="http://www.sec.gov/Archives/edgar/data/1293818/000107997320000597/opgen_8k.htm" STYLE="-sec-extract: exhibit">July 15, 2020 (Items 8.01 and 9.01)</A>; <A HREF="http://www.sec.gov/Archives/edgar/data/1293818/000107997320000657/opgen_8k.htm" STYLE="-sec-extract: exhibit">August 10, 2020 (Items 8.01 and 9.01)</A>, <A HREF="http://www.sec.gov/Archives/edgar/data/1293818/000107997320000663/opgen_8ka.htm" STYLE="-sec-extract: exhibit">as amended on August 12, 2020</A>; <A HREF="http://www.sec.gov/Archives/edgar/data/1293818/000107997320000661/opgen_8k.htm" STYLE="-sec-extract: exhibit">August 11, 2020
(Items 5.02, 5.03, 5.08 and 9.01)</A>; and</FONT></TD></TR></TABLE>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 12pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 12pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.5in"></TD><TD STYLE="width: 0.5in"><FONT STYLE="font-family: Symbol; font-size: 10pt">&#183;</FONT></TD><TD><FONT STYLE="font-size: 10pt">The description of the Registrant&rsquo;s common stock contained in the Company&rsquo;s <A HREF="http://www.sec.gov/Archives/edgar/data/1293818/000110465915032076/a15-10333_18a12b.htm" STYLE="-sec-extract: exhibit">Registration
Statement on Form 8-A (File No. 001-37367)</A> filed with the Commission on April 30, 2015, pursuant to Section 12(b) of the Securities
Exchange Act of 1934, as amended (the &#8223;Exchange Act&rdquo;), including any amendment or report filed for the purpose of updating
such description.</FONT></TD></TR></TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-indent: 0.5in">In addition, all reports and other documents
subsequently filed by the Registrant pursuant to Sections 13(a), 13(c), 14 and 15(d) of the Exchange Act prior to the filing of
a post-effective amendment which indicates that all securities offered hereby have been sold or which deregisters all securities
then remaining unsold, shall be deemed to be incorporated by reference herein and to be a part hereof from the date of filing of
such document. Any statement contained in a document incorporated or deemed to be incorporated by reference herein shall be deemed
to be modified or superseded for purposes of this Registration Statement to the extent that a statement contained herein or in
any other subsequently filed document which also is or is deemed to be incorporated by reference herein modifies or supersedes
such statement. The statements required to be so modified or superseded shall not be deemed, except as so modified or superseded,
to constitute a part of this Registration Statement.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>


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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0"><B>ITEM 4. DESCRIPTION OF SECURITIES.</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">Not applicable.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0"><FONT STYLE="text-transform: uppercase"><B>Item 5. Interests of
Named Experts and Counsel.</B></FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0"><FONT STYLE="text-transform: uppercase"><B>&nbsp;</B></FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">&#9;Not applicable.&#9;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0"><B>ITEM 6. INDEMNIFICATION OF DIRECTORS AND OFFICERS.</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-indent: 0.5in">Section 145 of the Delaware General Corporation
Law, or the DGCL, authorizes a corporation to indemnify its directors and officers against liabilities arising out of actions,
suits and proceedings to which they are made or threatened to be made a party by reason of the fact that they have served or are
currently serving as a director or officer to a corporation. The indemnity may cover expenses (including attorneys&rsquo; fees)
judgments, fines and amounts paid in settlement actually and reasonably incurred by the director or officer in connection with
any such action, suit or proceeding. Section 145 permits corporations to pay expenses (including attorneys&rsquo; fees) incurred
by directors and officers in advance of the final disposition of such action, suit or proceeding. In addition, Section 145 provides
that a corporation has the power to purchase and maintain insurance on behalf of its directors and officers against any liability
asserted against them and incurred by them in their capacity as a director or officer, or arising out of their status as such,
whether or not the corporation would have the power to indemnify the director or officer against such liability under Section 145.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-indent: 0.5in">We have adopted provisions in our certificate
of incorporation and bylaws that limit or eliminate the personal liability of our directors to the fullest extent permitted by
the DGCL, as it now exists or may in the future be amended. Consequently, a director will not be personally liable to us or our
stockholders for monetary damages or breach of fiduciary duty as a director, except for liability for:</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-indent: 0.5in">&bull;&#9;any breach of the director&rsquo;s
duty of loyalty to us or our stockholders;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-indent: 0.5in">&bull;&#9;any act or omission not in good faith
or that involves intentional misconduct or a knowing violation of law;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-indent: 0.5in">&bull;&#9;any unlawful payments related to dividends
or unlawful stock purchases, redemptions or other distributions; or</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-indent: 0.5in">&bull;&#9;any transaction from which the director
derived an improper personal benefit.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-indent: 0.5in">These limitations of liability do not alter
director liability under the federal securities laws and do not affect the availability of equitable remedies such as an injunction
or rescission.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-indent: 0.5in">In addition, our bylaws provide that:</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-indent: 0.5in">&bull;&#9;we will indemnify our directors, officers
and, in the discretion of our board of directors, certain employees to the fullest extent permitted by the DGCL, as it now exists
or may in the future be amended; and</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-indent: 0.5in">&bull;&#9;we will advance reasonable expenses,
including attorneys&rsquo; fees, to our directors and, in the discretion of our board of directors, to our officers and certain
employees, in connection with legal proceedings relating to their service for or on behalf of us, subject to limited exceptions.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-indent: 0.5in"></P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-indent: 0.5in">We have entered into indemnification agreements
with each of our directors and executive officers. These agreements provide that we will indemnify each of our directors, such
executive officers and, at times, their affiliates to the fullest extent permitted by Delaware law. We will advance expenses, including
attorneys&rsquo; fees (but excluding judgments, fines and settlement amounts), to each indemnified director, executive officer
or affiliate in connection with any proceeding in which indemnification is available and we will indemnify our directors and officers
for any action or proceeding arising out of that person&rsquo;s services as a director or officer brought on behalf of us and/or
in furtherance of our rights. Additionally, each of our directors may have certain rights to indemnification, advancement of expenses
and/or insurance provided by their affiliates, which indemnification relates to and might apply to the same proceedings arising
out of such director&rsquo;s services as a director referenced herein. Nonetheless, we have agreed in the indemnification agreements
that our obligations to those same directors are primary and any obligation of the affiliates of those directors to advance expenses
or to provide indemnification for the expenses or liabilities incurred by those directors are secondary.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-indent: 0.5in">We also maintain general liability insurance
which covers certain liabilities of our directors and officers arising out of claims based on acts or omissions in their capacities
as directors or officers, including liabilities under the Securities Act.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0"><B>ITEM 7. EXEMPTION FROM REGISTRATION CLAIMED.</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-indent: 0.5in">Not applicable.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0"><B>ITEM 8. EXHIBITS.</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-indent: 0.5in">The Exhibits to this Registration Statement
are listed in the Exhibit Index below, which is incorporated herein by reference.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0"><B>ITEM 9. UNDERTAKINGS.</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">(a) The undersigned Registrant hereby undertakes:</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-indent: 0.25in">(1) To file, during any period in which offers
or sales are being made, a post-effective amendment to this Registration Statement:</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-indent: 0.5in">(i) To include any prospectus required by Section
10(a)(3) of the Securities Act;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-indent: 0.5in">(ii) To reflect in the prospectus any facts
or events arising after the effective date of the registration statement (or the most recent post-effective amendment thereof)
which, individually or in the aggregate, represent a fundamental change in the information set forth in this registration statement.
Notwithstanding the foregoing, any increase or decrease in volume of securities offered (if the total dollar value of securities
offered would not exceed that which was registered) and any deviation from the low or high end of the estimated maximum offering
range may be reflected in the form of prospectus filed with the Commission pursuant to Rule 424(b) if, in the aggregate, the changes
in volume and price represent no more than 20 percent change in the maximum aggregate offering price set forth in the &ldquo;Calculation
of Registration Fee&rdquo; table in the effective registration statement; and</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-indent: 0.5in">(iii) To include any material information with
respect to the plan of distribution not previously disclosed in this registration statement or any material change to such information
in the registration statement;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">provided, however, that the undertakings set forth in paragraphs
(a)(1)(i) and (a)(1)(ii) above do not apply if information required to be included in a post-effective amendment by those paragraphs
is contained in reports filed with or furnished to the Commission by the Registrant pursuant to Section 13 or Section 15(d) of
the Exchange Act that are incorporated by reference in this registration statement;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-indent: 0.25in">(2) That, for the purpose of determining any
liability under the Securities Act, each such post-effective amendment shall be deemed to be a new registration statement relating
to the securities offered therein, and the offering of such securities at that time shall be deemed to be the initial bona fide
offering thereof; and</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-indent: 0.25in">(3) To remove from registration by means of
a post-effective amendment any of the securities being registered which remain unsold at the termination of the offering.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">(b) The undersigned Registrant hereby further undertakes that, for
purposes of determining any liability under the Securities Act, each filing of the Registrant&rsquo;s annual report pursuant to
Section 13(a) or Section 15(d) of the Exchange Act and, where applicable, each filing of the Plan&rsquo;s annual report pursuant
to Section 15(d) under the Exchange Act, that is incorporated by reference in this Registration Statement shall be deemed to be
a new registration statement relating to the securities offered therein, and the offering of such securities at the time shall
be deemed to be the initial bona fide offering thereof.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0"></P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">(c) Insofar as indemnification for liabilities arising under the
Securities Act may be permitted to directors, officers and controlling persons of the Registrant pursuant to the foregoing provisions,
or otherwise, the Registrant has been advised that in the opinion of the Commission such indemnification is against public policy
as expressed in the Securities Act and is, therefore, unenforceable. In the event that a claim for indemnification against such
liabilities (other than the payment by the Registrant of expenses incurred or paid by a director, officer or controlling person
of the Registrant in the successful defense of any action, suit or proceeding) is asserted by such director, officer or controlling
person in connection with the securities being registered, the Registrant will, unless in the opinion of its counsel the matter
has been settled by controlling precedent, submit to a court of appropriate jurisdiction the question whether such indemnification
by it is against public policy as expressed in the Securities Act and will be governed by the final adjudication of such issues.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>


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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center"><B>SIGNATURES</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-indent: 0.5in">Pursuant to the requirements of the Securities
Act of 1933, the Registrant certifies that it has reasonable grounds to believe that it meets all of the requirements for filing
on Form S-8 and has duly caused this Registration Statement to be signed on its behalf by the undersigned, thereunto duly authorized,
in the City of Gaithersburg, State of Maryland on the 14<SUP>th</SUP> day of August, 2020.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-indent: 0.5in">&nbsp;</P>

<TABLE BORDER="0" CELLSPACING="0" CELLPADDING="0" STYLE="width: 100%; font: 10pt Times New Roman, Times, Serif">
<TR>
    <TD STYLE="vertical-align: top">&nbsp;</TD>
    <TD COLSPAN="2"><B>OpGen, Inc.</B></TD>
</TR>
<TR>
    <TD STYLE="vertical-align: top">&nbsp;</TD>
    <TD COLSPAN="2">&nbsp;</TD></TR>
<TR>
    <TD STYLE="vertical-align: top; width: 50%">&nbsp;</TD>
    <TD STYLE="width: 4%">&nbsp;By:</TD>
    <TD STYLE="vertical-align: top; width: 46%">/s/ Oliver Schacht, Ph.D.</TD>
</TR>
<TR>
    <TD STYLE="vertical-align: top">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD STYLE="vertical-align: top; border-top: #000000 1px solid">Oliver Schacht, Ph.D.<BR>Chief Executive Officer</TD>
</TR>
</TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left; text-indent: 0pt; margin-top: 0pt; margin-bottom: 6pt">&nbsp;&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0 0 12pt">KNOW ALL BY THESE PRESENTS, that each undersigned director
of OpGen, Inc. constitutes and appoints Timothy C. Dec and Oliver Schacht, Ph.D., and each of them, as the true and lawful attorney-in-fact
and agent, with full power of substitution and resubstitution, for such person and in such person&rsquo;s name, place and stead,
in any and all capacities, to sign any or all amendments to this Registration Statement, and to file the same, with all exhibits
thereto and other documents in connection therewith, with the U.S. Securities and Exchange Commission, granting unto said attorney-in-fact
and agent full power and authority to do and perform each and every act and thing requisite and necessary to be done in and about
the premises, as fully to all intents and purposes as he or she might or could do in person, hereby ratifying and confirming all
that said attorney-in-fact and agent, or his substitute or substitutes, may lawfully do or cause to be done by virtue hereof.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">Pursuant to the requirements of the Securities Act of 1933, this
Registration Statement has been signed by the following persons in the capacities and on the dates indicated.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 12pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
<TR STYLE="vertical-align: bottom">
    <TD STYLE="width: 43%; border-bottom: Black 1pt solid; text-align: center"><FONT STYLE="font-size: 10pt"><B>Signature</B></FONT></TD>
    <TD STYLE="width: 2%">&nbsp;</TD>
    <TD STYLE="width: 36%; border-bottom: Black 1pt solid; text-align: center"><FONT STYLE="font-size: 10pt"><B>Title(s)</B></FONT></TD>
    <TD STYLE="width: 1%">&nbsp;</TD>
    <TD STYLE="width: 18%; border-bottom: Black 1pt solid; text-align: center"><FONT STYLE="font-size: 10pt"><B>Date</B></FONT></TD></TR>
<TR STYLE="vertical-align: bottom">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD STYLE="text-align: center">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom">
    <TD STYLE="border-bottom: Black 1pt solid"><FONT STYLE="font-size: 10pt">/s/ Oliver Schacht, Ph.D.</FONT></TD>
    <TD>&nbsp;</TD>
    <TD ROWSPAN="3"><FONT STYLE="font-size: 10pt">Chief Executive Officer <BR>
and Director (principal executive <BR>
officer)</FONT></TD>
    <TD>&nbsp;</TD>
    <TD STYLE="text-align: center"><FONT STYLE="font-size: 10pt">August 14, 2020</FONT></TD></TR>
<TR STYLE="vertical-align: bottom">
    <TD><FONT STYLE="font-size: 10pt">Oliver Schacht, Ph.D.</FONT></TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD STYLE="text-align: center">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD STYLE="text-align: center">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD STYLE="text-align: center">&nbsp;</TD></TR>
<TR>
    <TD STYLE="vertical-align: bottom; border-bottom: Black 1pt solid"><FONT STYLE="font-size: 10pt">/s/ Timothy C. Dec</FONT></TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD ROWSPAN="4"><FONT STYLE="font-size: 10pt">Chief Financial Officer (principal financial officer and principal accounting officer)</FONT></TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; text-align: center"><FONT STYLE="font-size: 10pt">August 14, 2020</FONT></TD></TR>
<TR STYLE="vertical-align: bottom">
    <TD><FONT STYLE="font-size: 10pt">Timothy C. Dec</FONT></TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD STYLE="text-align: center">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD STYLE="text-align: center">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD STYLE="text-align: center">&nbsp;</TD></TR>
<TR>
    <TD STYLE="vertical-align: bottom; border-bottom: Black 1pt solid"><FONT STYLE="font-size: 10pt">/s/ Mario Crovetto</FONT></TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD ROWSPAN="2"><FONT STYLE="font-size: 10pt">Director</FONT></TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; text-align: center"><FONT STYLE="font-size: 10pt">August 14, 2020</FONT></TD></TR>
<TR STYLE="vertical-align: bottom">
    <TD><FONT STYLE="font-size: 10pt">Mario Crovetto</FONT></TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD STYLE="text-align: center">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD STYLE="text-align: center">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom">
    <TD STYLE="border-bottom: Black 1pt solid"><FONT STYLE="font-size: 10pt">/s/ R. Donald. Elsey</FONT></TD>
    <TD>&nbsp;</TD>
    <TD><FONT STYLE="font-size: 10pt">Director</FONT></TD>
    <TD>&nbsp;</TD>
    <TD STYLE="text-align: center"><FONT STYLE="font-size: 10pt">August 14, 2020</FONT></TD></TR>
<TR STYLE="vertical-align: bottom">
    <TD><FONT STYLE="font-size: 10pt">R. Donald Elsey</FONT></TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD STYLE="text-align: center">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD STYLE="text-align: center">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom">
    <TD STYLE="border-bottom: Black 1pt solid"><FONT STYLE="font-size: 10pt">/s/ Prabhavathi Fernandes</FONT></TD>
    <TD>&nbsp;</TD>
    <TD><FONT STYLE="font-size: 10pt">Director</FONT></TD>
    <TD>&nbsp;</TD>
    <TD STYLE="text-align: center"><FONT STYLE="font-size: 10pt">August 14, 2020</FONT></TD></TR>
<TR STYLE="vertical-align: bottom">
    <TD><FONT STYLE="font-size: 10pt">Prabhavathi Fernandes</FONT></TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD STYLE="text-align: center">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD STYLE="text-align: center">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom">
    <TD STYLE="border-bottom: Black 1pt solid"><FONT STYLE="font-size: 10pt">/s/ Evan Jones</FONT></TD>
    <TD>&nbsp;</TD>
    <TD><FONT STYLE="font-size: 10pt">Director</FONT></TD>
    <TD>&nbsp;</TD>
    <TD STYLE="text-align: center"><FONT STYLE="font-size: 10pt">August 14, 2020</FONT></TD></TR>
<TR STYLE="vertical-align: bottom">
    <TD><FONT STYLE="font-size: 10pt">Evan Jones</FONT></TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD STYLE="text-align: center">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD STYLE="text-align: center">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom">
    <TD STYLE="border-bottom: Black 1pt solid"><FONT STYLE="font-size: 10pt">/s/ William E. Rhodes</FONT></TD>
    <TD>&nbsp;</TD>
    <TD><FONT STYLE="font-size: 10pt">Director</FONT></TD>
    <TD>&nbsp;</TD>
    <TD STYLE="text-align: center"><FONT STYLE="font-size: 10pt">August 14, 2020</FONT></TD></TR>
<TR STYLE="vertical-align: bottom">
    <TD><FONT STYLE="font-size: 10pt">William E. Rhodes</FONT></TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD STYLE="text-align: center">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD STYLE="text-align: center">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD STYLE="text-align: center">&nbsp;</TD></TR>
</TABLE>
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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center"><B>EXHIBIT INDEX</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0"><B>&nbsp;</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0"></P>
<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 0"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0"></TD><TD STYLE="width: 1in"><P STYLE="margin-top: 0; margin-bottom: 0"><B>Exhibit</B></P>
                                                 <P STYLE="margin-top: 0; margin-bottom: 0"><B>Number</B></P></TD><TD STYLE="text-align: left; vertical-align: bottom"><B>Description</B></TD></TR></TABLE>


<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 0"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0"></TD><TD STYLE="width: 1in">5.1</TD><TD><A HREF="ex5x1.htm">Opinion of Ballard Spahr LLP (filed herewith).</A></TD></TR></TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0 0 0 1in; text-indent: -1in">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 0"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0"></TD><TD STYLE="width: 1in">10.1</TD><TD><A HREF="http://www.sec.gov/Archives/edgar/data/1293818/000107997320000254/ex10x1.htm" STYLE="-sec-extract: exhibit">Amended and Restated Stock Option Plan, as assumed and adopted as of April 1, 2020 (incorporated by reference to Exhibit 10.1
to the Company&rsquo;s Current Report on 8-K, filed with the Commission on April 2, 2020).</A></TD></TR></TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 0"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0"></TD><TD STYLE="width: 1in">23.1</TD><TD><A HREF="ex23x1.htm">Consent of CohnReznick LLP (filed herewith).</A></TD></TR></TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0 0 0 1in; text-indent: -1in">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 0"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0"></TD><TD STYLE="width: 1in">23.2</TD><TD><A HREF="ex5x1.htm">Consent of Ballard Spahr LLP (contained in Exhibit 5.1).</A></TD></TR></TABLE>

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<TD STYLE="width: 0"></TD><TD STYLE="width: 1in">24.1</TD><TD>Power of Attorney (on signature page).</TD></TR></TABLE>

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[{"type": "S-8", "sequence": "1", "filename": "opgen_s-8.htm", "description": "FORM S-8", "secsgml_size_bytes": 57292}]
{"company-data": {"conformed-name": "OPGEN INC", "cik": "0001293818", "assigned-sic": "8071", "irs-number": "061614015", "state-of-incorporation": "DE", "fiscal-year-end": "1231"}, "filing-values": {"form-type": "S-8", "act": "33", "file-number": "333-246354", "film-number": "201106336"}, "business-address": {"street1": "708 QUINCE ORCHARD ROAD", "street2": "SUITE 205", "city": "GAITHERSBURG", "state": "MD", "zip": "20878", "phone": "240-813-1260"}, "mail-address": {"street1": "708 QUINCE ORCHARD ROAD", "street2": "SUITE 205", "city": "GAITHERSBURG", "state": "MD", "zip": "20878"}}
As filed with the Securities and Exchange
Commission on August 14, 2020
Registration No. 333-
UNITED STATES
SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM S-8
REGISTRATION STATEMENT
UNDER
THE SECURITIES ACT OF 1933
OPGEN, INC.
(Exact name of registrant as specified in its
charter)
Delaware
06-1614015
(State or other jurisdiction of incorporation or organization)
(I.R.S. Employer Identification No.)
708 Quince Orchard Road
Gaithersburg, MD 20878
(Address of Principal Executive Offices)(Zip Code)
AMENDED AND RESTATED STOCK OPTION PLAN
(Full title of the plan)
Timothy C. Dec
Chief Financial Officer
708 Quince Orchard Road
Gaithersburg, MD 20878
(Name and address of agent for service)
(240) 813-1260
(Telephone number, including area code, of agent
for service)
with a copy to:
Peter Jaslow, Esquire
Ballard Spahr LLP
1735 Market Street
51st Floor
Philadelphia, PA 19103
215-665-8500
Indicate by check mark whether the registrant
is a large accelerated filer, an accelerated filer, a non-accelerated filer, or a smaller reporting company.  See the
definitions of "large accelerated filer," "accelerated filer," "smaller reporting company,"
and "emerging growth company" in Rule 12b-2 of the Exchange Act.
Large Accelerated Filer
[_]
Accelerated Filer
[_]
Non-Accelerated Filer
[_]
Smaller Reporting Company
[X]
Emerging Growth Company
[X]
If an emerging growth company, indicate by check mark if the registrant
has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided
to Section 7(a)(2)(B) of the Securities Act. [_]
CALCULATION OF REGISTRATION FEE
Title of Securities to be Registered
Number of Shares to be Registered(1)
Proposed Maximum Offering Price Per Share
Proposed Maximum Aggregate Offering Price
Amount of Registration Fee
Common Stock, par value $0.01 per share, reserved for issuance pursuant to the Amended and Restated Stock Option Plan, as assumed and adopted as of April 1, 2020
134,371 (2)
$
2.35 (3)
$
315,771.85
$
40.99
(1)
Pursuant to Rule 416(a) promulgated under the Securities Act of 1933, as amended, or the Securities Act, this registration
statement, or this Registration Statement, also covers an indeterminate number of additional shares of common stock issuable under
the Amended and Restated Stock Option Plan, as assumed and adopted as of April 1, 2020 (the "Assumed Plan") in the
event the number of outstanding shares of the Registrant is increased by reason of any stock dividend, stock split, recapitalization,
merger, consolidation or reorganization or similar transaction.
(2)
Represents 134,371 shares of the Registrant's common stock reserved for issuance under the Assumed Plan.
(3)
Estimated in accordance with Rule 457(h) solely for the purpose of calculating the registration fee on the basis of the average
of the high and low prices reported for the common stock on the NASDAQ Capital Market on August 13, 2020.
PART I
INFORMATION REQUIRED IN THE SECTION 10(a)
PROSPECTUS
As permitted by the rules of the United States
Securities and Exchange Commission, or the Commission, this Registration Statement omits the information specified in the instructions
to Part I of Form S-8. Documents containing such information will be sent or given to participants in the employee benefit plans,
as defined in Rule 405 under the Securities Act, covered by this Registration Statement as required by Rule 428(b)(1) under the
Securities Act. Those documents are not being filed with the Commission as part of this Registration Statement or as prospectuses
or prospectus supplements pursuant to Rule 424 under the Securities Act. Those documents, and the documents incorporated by reference
in this Registration Statement pursuant to Item 3 of Part II hereof, taken together, constitute a prospectus that meets the requirements
of Section 10(a) of the Securities Act.
PART II
INFORMATION REQUIRED IN THE REGISTRATION
STATEMENT
ITEM 3. INCORPORATION OF DOCUMENTS BY REFERENCE.
The following documents, previously filed with
the Commission, are hereby incorporated by reference into this Registration Statement:
·
The Registrant's
Annual Report on Form 10-K
, filed with the Commission on March 24, 2020,
for the year ended December 31, 2019, which contains the Registrant's audited financial statements for the latest fiscal
year for which such statements have been filed;
·
The Registrant's Quarterly Report on Form 10-Q for the quarters ended
March 31, 2020
and
June 30, 2020
, filed with the Commission on May 8, 2020 and August 14, 2020, respectively;
·
The Registrant's Current Reports on Form 8-K, filed with the Commission on
January 23,
2020 (Item 8.01)
;
January 30, 2020 (Item 8.01 and 9.01)
;
February 12, 2020 (Items 1.01 and 9.01)
;
February 12, 2020 (Items 8.01
and 9.01)
;
February 20, 2020 (Items 8.01 and 9.01)
;
February 28, 2020 (Items 1.01 and 9.01)
;
March 10, 2020 (Items 8.01 and 9.01)
;
March 16, 2020 (Items 8.01 and 9.01)
;
March 19, 2020 (Items 8.01 and 9.01)
;
March 24, 2020 (Items 8.01 and 9.01, but only exhibit
99.2 thereof)
March 30, 2020 (Items 5.07, 8.01 and 9.01)
;
April 2, 2020 (Items 2.01, 5.02, 8.01 and 9.01)
,
as amended on June 15,
2020
;
April 16, 2020 (Item 8.01)
;
April 28, 2020 (Items 1.01, 2.03 and 9.01)
;
May 7, 2020 (Item 5.02)
;
May 11, 2020 (Items 8.01
and 9.01)
;
June 3, 2020 (Items 8.01 and 9.01)
;
July 13, 2020 (Items 1.01, 2.03, 8.01 and 9.01)
;
July 14, 2020 (Items 8.01 and 9.01)
;
July 15, 2020 (Items 8.01 and 9.01)
;
August 10, 2020 (Items 8.01 and 9.01)
,
as amended on August 12, 2020
;
August 11, 2020
(Items 5.02, 5.03, 5.08 and 9.01)
; and
·
The description of the Registrant's common stock contained in the Company's
Registration
Statement on Form 8-A (File No. 001-37367)
filed with the Commission on April 30, 2015, pursuant to Section 12(b) of the Securities
Exchange Act of 1934, as amended (the ‟Exchange Act"), including any amendment or report filed for the purpose of updating
such description.
In addition, all reports and other documents
subsequently filed by the Registrant pursuant to Sections 13(a), 13(c), 14 and 15(d) of the Exchange Act prior to the filing of
a post-effective amendment which indicates that all securities offered hereby have been sold or which deregisters all securities
then remaining unsold, shall be deemed to be incorporated by reference herein and to be a part hereof from the date of filing of
such document. Any statement contained in a document incorporated or deemed to be incorporated by reference herein shall be deemed
to be modified or superseded for purposes of this Registration Statement to the extent that a statement contained herein or in
any other subsequently filed document which also is or is deemed to be incorporated by reference herein modifies or supersedes
such statement. The statements required to be so modified or superseded shall not be deemed, except as so modified or superseded,
to constitute a part of this Registration Statement.
ITEM 4. DESCRIPTION OF SECURITIES.
Not applicable.
Item 5. Interests of
Named Experts and Counsel.
Not applicable.
ITEM 6. INDEMNIFICATION OF DIRECTORS AND OFFICERS.
Section 145 of the Delaware General Corporation
Law, or the DGCL, authorizes a corporation to indemnify its directors and officers against liabilities arising out of actions,
suits and proceedings to which they are made or threatened to be made a party by reason of the fact that they have served or are
currently serving as a director or officer to a corporation. The indemnity may cover expenses (including attorneys' fees)
judgments, fines and amounts paid in settlement actually and reasonably incurred by the director or officer in connection with
any such action, suit or proceeding. Section 145 permits corporations to pay expenses (including attorneys' fees) incurred
by directors and officers in advance of the final disposition of such action, suit or proceeding. In addition, Section 145 provides
that a corporation has the power to purchase and maintain insurance on behalf of its directors and officers against any liability
asserted against them and incurred by them in their capacity as a director or officer, or arising out of their status as such,
whether or not the corporation would have the power to indemnify the director or officer against such liability under Section 145.
We have adopted provisions in our certificate
of incorporation and bylaws that limit or eliminate the personal liability of our directors to the fullest extent permitted by
the DGCL, as it now exists or may in the future be amended. Consequently, a director will not be personally liable to us or our
stockholders for monetary damages or breach of fiduciary duty as a director, except for liability for:
•	any breach of the director's
duty of loyalty to us or our stockholders;
•	any act or omission not in good faith
or that involves intentional misconduct or a knowing violation of law;
•	any unlawful payments related to dividends
or unlawful stock purchases, redemptions or other distributions; or
•	any transaction from which the director
derived an improper personal benefit.
These limitations of liability do not alter
director liability under the federal securities laws and do not affect the availability of equitable remedies such as an injunction
or rescission.
In addition, our bylaws provide that:
•	we will indemnify our directors, officers
and, in the discretion of our board of directors, certain employees to the fullest extent permitted by the DGCL, as it now exists
or may in the future be amended; and
•	we will advance reasonable expenses,
including attorneys' fees, to our directors and, in the discretion of our board of directors, to our officers and certain
employees, in connection with legal proceedings relating to their service for or on behalf of us, subject to limited exceptions.
We have entered into indemnification agreements
with each of our directors and executive officers. These agreements provide that we will indemnify each of our directors, such
executive officers and, at times, their affiliates to the fullest extent permitted by Delaware law. We will advance expenses, including
attorneys' fees (but excluding judgments, fines and settlement amounts), to each indemnified director, executive officer
or affiliate in connection with any proceeding in which indemnification is available and we will indemnify our directors and officers
for any action or proceeding arising out of that person's services as a director or officer brought on behalf of us and/or
in furtherance of our rights. Additionally, each of our directors may have certain rights to indemnification, advancement of expenses
and/or insurance provided by their affiliates, which indemnification relates to and might apply to the same proceedings arising
out of such director's services as a director referenced herein. Nonetheless, we have agreed in the indemnification agreements
that our obligations to those same directors are primary and any obligation of the affiliates of those directors to advance expenses
or to provide indemnification for the expenses or liabilities incurred by those directors are secondary.
We also maintain general liability insurance
which covers certain liabilities of our directors and officers arising out of claims based on acts or omissions in their capacities
as directors or officers, including liabilities under the Securities Act.
ITEM 7. EXEMPTION FROM REGISTRATION CLAIMED.
Not applicable.
ITEM 8. EXHIBITS.
The Exhibits to this Registration Statement
are listed in the Exhibit Index below, which is incorporated herein by reference.
ITEM 9. UNDERTAKINGS.
(a) The undersigned Registrant hereby undertakes:
(1) To file, during any period in which offers
or sales are being made, a post-effective amendment to this Registration Statement:
(i) To include any prospectus required by Section
10(a)(3) of the Securities Act;
(ii) To reflect in the prospectus any facts
or events arising after the effective date of the registration statement (or the most recent post-effective amendment thereof)
which, individually or in the aggregate, represent a fundamental change in the information set forth in this registration statement.
Notwithstanding the foregoing, any increase or decrease in volume of securities offered (if the total dollar value of securities
offered would not exceed that which was registered) and any deviation from the low or high end of the estimated maximum offering
range may be reflected in the form of prospectus filed with the Commission pursuant to Rule 424(b) if, in the aggregate, the changes
in volume and price represent no more than 20 percent change in the maximum aggregate offering price set forth in the "Calculation
of Registration Fee" table in the effective registration statement; and
(iii) To include any material information with
respect to the plan of distribution not previously disclosed in this registration statement or any material change to such information
in the registration statement;
provided, however, that the undertakings set forth in paragraphs
(a)(1)(i) and (a)(1)(ii) above do not apply if information required to be included in a post-effective amendment by those paragraphs
is contained in reports filed with or furnished to the Commission by the Registrant pursuant to Section 13 or Section 15(d) of
the Exchange Act that are incorporated by reference in this registration statement;
(2) That, for the purpose of determining any
liability under the Securities Act, each such post-effective amendment shall be deemed to be a new registration statement relating
to the securities offered therein, and the offering of such securities at that time shall be deemed to be the initial bona fide
offering thereof; and
(3) To remove from registration by means of
a post-effective amendment any of the securities being registered which remain unsold at the termination of the offering.
(b) The undersigned Registrant hereby further undertakes that, for
purposes of determining any liability under the Securities Act, each filing of the Registrant's annual report pursuant to
Section 13(a) or Section 15(d) of the Exchange Act and, where applicable, each filing of the Plan's annual report pursuant
to Section 15(d) under the Exchange Act, that is incorporated by reference in this Registration Statement shall be deemed to be
a new registration statement relating to the securities offered therein, and the offering of such securities at the time shall
be deemed to be the initial bona fide offering thereof.
(c) Insofar as indemnification for liabilities arising under the
Securities Act may be permitted to directors, officers and controlling persons of the Registrant pursuant to the foregoing provisions,
or otherwise, the Registrant has been advised that in the opinion of the Commission such indemnification is against public policy
as expressed in the Securities Act and is, therefore, unenforceable. In the event that a claim for indemnification against such
liabilities (other than the payment by the Registrant of expenses incurred or paid by a director, officer or controlling person
of the Registrant in the successful defense of any action, suit or proceeding) is asserted by such director, officer or controlling
person in connection with the securities being registered, the Registrant will, unless in the opinion of its counsel the matter
has been settled by controlling precedent, submit to a court of appropriate jurisdiction the question whether such indemnification
by it is against public policy as expressed in the Securities Act and will be governed by the final adjudication of such issues.
SIGNATURES
Pursuant to the requirements of the Securities
Act of 1933, the Registrant certifies that it has reasonable grounds to believe that it meets all of the requirements for filing
on Form S-8 and has duly caused this Registration Statement to be signed on its behalf by the undersigned, thereunto duly authorized,
in the City of Gaithersburg, State of Maryland on the 14
th
day of August, 2020.
OpGen, Inc.
By:
/s/ Oliver Schacht, Ph.D.
Oliver Schacht, Ph.D.
Chief Executive Officer
KNOW ALL BY THESE PRESENTS, that each undersigned director
of OpGen, Inc. constitutes and appoints Timothy C. Dec and Oliver Schacht, Ph.D., and each of them, as the true and lawful attorney-in-fact
and agent, with full power of substitution and resubstitution, for such person and in such person's name, place and stead,
in any and all capacities, to sign any or all amendments to this Registration Statement, and to file the same, with all exhibits
thereto and other documents in connection therewith, with the U.S. Securities and Exchange Commission, granting unto said attorney-in-fact
and agent full power and authority to do and perform each and every act and thing requisite and necessary to be done in and about
the premises, as fully to all intents and purposes as he or she might or could do in person, hereby ratifying and confirming all
that said attorney-in-fact and agent, or his substitute or substitutes, may lawfully do or cause to be done by virtue hereof.
Pursuant to the requirements of the Securities Act of 1933, this
Registration Statement has been signed by the following persons in the capacities and on the dates indicated.
Signature
Title(s)
Date
/s/ Oliver Schacht, Ph.D.
Chief Executive Officer
and Director (principal executive
officer)
August 14, 2020
Oliver Schacht, Ph.D.
/s/ Timothy C. Dec
Chief Financial Officer (principal financial officer and principal accounting officer)
August 14, 2020
Timothy C. Dec
/s/ Mario Crovetto
Director
August 14, 2020
Mario Crovetto
/s/ R. Donald. Elsey
Director
August 14, 2020
R. Donald Elsey
/s/ Prabhavathi Fernandes
Director
August 14, 2020
Prabhavathi Fernandes
/s/ Evan Jones
Director
August 14, 2020
Evan Jones
/s/ William E. Rhodes
Director
August 14, 2020
William E. Rhodes
EXHIBIT INDEX
Exhibit
Number
Description
5.1
Opinion of Ballard Spahr LLP (filed herewith).
10.1
Amended and Restated Stock Option Plan, as assumed and adopted as of April 1, 2020 (incorporated by reference to Exhibit 10.1
to the Company's Current Report on 8-K, filed with the Commission on April 2, 2020).
23.1
Consent of CohnReznick LLP (filed herewith).
23.2
Consent of Ballard Spahr LLP (contained in Exhibit 5.1).
24.1
Power of Attorney (on signature page).