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<div style="FONT-SIZE: 11pt; FONT-FAMILY: 'Times New Roman', Times, serif; FONT-WEIGHT: bold; TEXT-ALIGN: center; MARGIN-LEFT: 36pt">As filed with the Securities and Exchange Commission on June 28, 2017</div>

<div style="FONT-SIZE: 11pt; FONT-FAMILY: 'Times New Roman', Times, serif; FONT-WEIGHT: bold; TEXT-ALIGN: right">Registration No. 333-</div>

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<font style="FONT-SIZE: 12pt">UNITED STATES SECURITIES AND EXCHANGE COMMISSION</font></div>

<div style="FONT-SIZE: 11pt; FONT-FAMILY: 'Times New Roman', Times, serif; FONT-WEIGHT: bold; TEXT-ALIGN: center">Washington, D.C. 20549</div>

<div style="FONT-SIZE: 11pt; FONT-FAMILY: 'Times New Roman', Times, serif; TEXT-ALIGN: center">________________</div>

<div style="FONT-SIZE: 14pt; FONT-FAMILY: 'Times New Roman', Times, serif; FONT-WEIGHT: bold; TEXT-ALIGN: center; MARGIN-TOP: 6pt"><font style="FONT-SIZE: 14pt">FORM S-8</font><font style="FONT-SIZE: 14pt; FONT-FAMILY: 'Times New Roman', Times, serif"><br>
</font><font style="FONT-SIZE: 14pt">REGISTRATION STATEMENT</font></div>

<div style="FONT-SIZE: 14pt; FONT-FAMILY: 'Times New Roman', Times, serif; FONT-WEIGHT: bold; TEXT-ALIGN: center">UNDER THE SECURITIES ACT OF 1933</div>

<div style="FONT-SIZE: 11pt; FONT-FAMILY: 'Times New Roman', Times, serif; TEXT-ALIGN: center">________________</div>

<div style="FONT-SIZE: 14pt; FONT-FAMILY: 'Times New Roman', Times, serif; FONT-WEIGHT: bold; COLOR: #000000; TEXT-ALIGN: center; MARGIN-TOP: 6pt">AVADEL PHARMACEUTICALS PLC</div>

<div style="FONT-SIZE: 10pt; FONT-FAMILY: 'Times New Roman', Times, serif; TEXT-ALIGN: center">(Exact name of Registrant as specified in its charter)</div>

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<div style="FONT-FAMILY: 'Times New Roman', Times, serif; FONT-WEIGHT: bold; TEXT-ALIGN: center">Ireland</div>
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<td style="FONT-SIZE: 11pt; WIDTH: 45.68%; VERTICAL-ALIGN: top">
<div style="FONT-FAMILY: 'Times New Roman', Times, serif; FONT-WEIGHT: bold; TEXT-ALIGN: center">98-1341933</div>
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<div style="FONT-FAMILY: 'Times New Roman', Times, serif; TEXT-ALIGN: center">(State or other jurisdiction of incorporation or organization)</div>
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<td style="FONT-SIZE: 10pt; WIDTH: 45.68%; VERTICAL-ALIGN: top">
<div style="FONT-FAMILY: 'Times New Roman', Times, serif; TEXT-ALIGN: center">(I.R.S. Employer Identification No.)</div>
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<td style="FONT-SIZE: 11pt; WIDTH: 54.32%; VERTICAL-ALIGN: top">&#160;</td>
<td style="FONT-SIZE: 11pt; WIDTH: 45.68%; VERTICAL-ALIGN: top">&#160;</td>
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<tr>
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<div style="FONT-SIZE: 11pt; FONT-FAMILY: 'Times New Roman', Times, serif; FONT-WEIGHT: bold; TEXT-ALIGN: center; MARGIN-LEFT: 1.5pt">Block 10-1</div>

<div style="FONT-SIZE: 11pt; FONT-FAMILY: 'Times New Roman', Times, serif; FONT-WEIGHT: bold; TEXT-ALIGN: center; MARGIN-LEFT: 1.5pt">Blanchardstown Corporate Park, Ballycoolin</div>

<div style="FONT-SIZE: 11pt; FONT-FAMILY: 'Times New Roman', Times, serif; FONT-WEIGHT: bold; TEXT-ALIGN: center; MARGIN-LEFT: 1.5pt">Dublin 15, Ireland</div>
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<div style="FONT-SIZE: 11pt">&#160;</div>

<div style="FONT-SIZE: 11pt">&#160;</div>

<div style="FONT-SIZE: 11pt; FONT-FAMILY: 'Times New Roman', Times, serif; FONT-WEIGHT: bold; TEXT-ALIGN: center">Not Applicable</div>
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<div style="FONT-FAMILY: 'Times New Roman', Times, serif; TEXT-ALIGN: center">(Address of Principal Executive Offices)</div>
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<div style="FONT-FAMILY: 'Times New Roman', Times, serif; TEXT-ALIGN: center">(Zip Code)</div>
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<div style="FONT-SIZE: 11pt; FONT-FAMILY: 'Times New Roman', Times, serif; TEXT-ALIGN: center">________________</div>

<div style="BACKGROUND-COLOR: #ffffff">
<div style="FONT-SIZE: 11pt; FONT-FAMILY: 'Times New Roman', Times, serif; FONT-WEIGHT: bold; COLOR: #000000; TEXT-ALIGN: center">2017 Omnibus Incentive Compensation Plan</div>

<div style="FONT-SIZE: 11pt; FONT-FAMILY: 'Times New Roman', Times, serif; FONT-WEIGHT: bold; COLOR: #000000; TEXT-ALIGN: center">2017 Employee Share Purchase Plan</div>
</div>

<div style="FONT-SIZE: 10pt; FONT-FAMILY: 'Times New Roman', Times, serif; TEXT-ALIGN: center">(Full title of the plans)</div>

<div style="FONT-SIZE: 10pt; FONT-FAMILY: 'Times New Roman', Times, serif; TEXT-ALIGN: center; MARGIN-TOP: 6pt"><font style="FONT-SIZE: 11pt; FONT-FAMILY: 'Times New Roman', Times, serif; FONT-WEIGHT: bold">Phillandas T. Thompson, Esq.</font><font style="FONT-SIZE: 10pt; FONT-FAMILY: 'Times New Roman', Times, serif"><br>
</font><font style="FONT-SIZE: 11pt; FONT-FAMILY: 'Times New Roman', Times, serif; FONT-WEIGHT: bold">Avadel Pharmaceuticals plc</font><font style="FONT-SIZE: 10pt; FONT-FAMILY: 'Times New Roman', Times, serif"><br>
</font><font style="FONT-SIZE: 11pt; FONT-FAMILY: 'Times New Roman', Times, serif; FONT-WEIGHT: bold">16640 Chesterfield Grove Road</font><font style="FONT-SIZE: 10pt; FONT-FAMILY: 'Times New Roman', Times, serif"><br>
</font><font style="FONT-SIZE: 11pt; FONT-FAMILY: 'Times New Roman', Times, serif; FONT-WEIGHT: bold">Suite 200</font><font style="FONT-SIZE: 10pt; FONT-FAMILY: 'Times New Roman', Times, serif"><br>
</font><font style="FONT-SIZE: 11pt; FONT-FAMILY: 'Times New Roman', Times, serif; FONT-WEIGHT: bold">Chesterfield, MO 63005</font><font style="FONT-SIZE: 10pt; FONT-FAMILY: 'Times New Roman', Times, serif"><br>
</font><font style="FONT-SIZE: 10pt">(Name and address of agent for service)</font></div>

<div style="FONT-SIZE: 11pt; FONT-FAMILY: 'Times New Roman', Times, serif; FONT-WEIGHT: bold; TEXT-ALIGN: center; MARGIN-TOP: 8pt">(636) 449-1840</div>

<div style="FONT-SIZE: 10pt; FONT-FAMILY: 'Times New Roman', Times, serif; TEXT-ALIGN: center">(Telephone number, including area code, of agent for service)</div>

<div style="FONT-SIZE: 11pt; FONT-FAMILY: 'Times New Roman', Times, serif; TEXT-ALIGN: center">________________</div>

<div style="FONT-SIZE: 11pt; FONT-FAMILY: 'Times New Roman', Times, serif; FONT-STYLE: italic; TEXT-ALIGN: center; MARGIN-TOP: 6pt">Copies of all correspondence to:</div>

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<div style="FONT-FAMILY: 'Times New Roman', Times, serif; FONT-WEIGHT: bold; TEXT-ALIGN: center">Timothy I Kahler, Esq.</div>
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<td style="FONT-SIZE: 11pt; WIDTH: 50%; VERTICAL-ALIGN: top">
<div style="FONT-FAMILY: 'Times New Roman', Times, serif; FONT-WEIGHT: bold; TEXT-ALIGN: center">Christopher McLaughlin, Esq.</div>
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<div style="FONT-FAMILY: 'Times New Roman', Times, serif; FONT-WEIGHT: bold; TEXT-ALIGN: center">Joseph Walsh, Esq.</div>
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<td style="FONT-SIZE: 11pt; WIDTH: 50%; VERTICAL-ALIGN: top">
<div style="FONT-FAMILY: 'Times New Roman', Times, serif; FONT-WEIGHT: bold; TEXT-ALIGN: center">Arthur Cox</div>
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<div style="FONT-FAMILY: 'Times New Roman', Times, serif; FONT-WEIGHT: bold; TEXT-ALIGN: center">Troutman Sanders LLP</div>
</td>
<td style="FONT-SIZE: 11pt; WIDTH: 50%; VERTICAL-ALIGN: top">
<div style="FONT-FAMILY: 'Times New Roman', Times, serif; FONT-WEIGHT: bold; TEXT-ALIGN: center">Ten Earlsfort Terrace</div>
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<div style="FONT-FAMILY: 'Times New Roman', Times, serif; FONT-WEIGHT: bold; TEXT-ALIGN: center">875 Third Avenue</div>
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<td style="FONT-SIZE: 11pt; WIDTH: 50%; VERTICAL-ALIGN: top">
<div style="FONT-FAMILY: 'Times New Roman', Times, serif; FONT-WEIGHT: bold; TEXT-ALIGN: center">Dublin 2, Ireland</div>
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<div style="FONT-FAMILY: 'Times New Roman', Times, serif; FONT-WEIGHT: bold; TEXT-ALIGN: center">New York, NY 10022</div>
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<td style="FONT-SIZE: 11pt; WIDTH: 50%; VERTICAL-ALIGN: top">
<div style="FONT-FAMILY: 'Times New Roman', Times, serif; FONT-WEIGHT: bold; TEXT-ALIGN: center">+353 1 618 0000</div>
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<div style="FONT-FAMILY: 'Times New Roman', Times, serif; FONT-WEIGHT: bold; TEXT-ALIGN: center">(212) 704-6000</div>
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<td style="FONT-SIZE: 11pt; WIDTH: 50%; VERTICAL-ALIGN: top">&#160;</td>
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<div><br>
 ________________</div>
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<div style="FONT-SIZE: 10pt; FONT-FAMILY: 'Times New Roman', Times, serif; TEXT-ALIGN: justify; MARGIN-TOP: 6pt">Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, a smaller reporting company or an emerging growth company. See the definitions of "large accelerated filer," "accelerated filer," "smaller reporting company," and "emerging growth company" in Rule 12b-2 of the Exchange Act.</div>

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<div style="FONT-SIZE: 10pt; FONT-FAMILY: 'Times New Roman', Times, serif; TEXT-ALIGN: left; MARGIN-LEFT: 18pt">Large accelerated filer <font style="FONT-SIZE: 10pt; FONT-FAMILY: 'Wingdings 2', serif">&#163;</font></div>
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<div style="FONT-SIZE: 10pt; FONT-FAMILY: 'Times New Roman', Times, serif; TEXT-ALIGN: left">Accelerated filer <font style="FONT-SIZE: 10pt; FONT-FAMILY: 'Wingdings 2', serif">S</font></div>
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<div style="FONT-SIZE: 10pt; FONT-FAMILY: 'Times New Roman', Times, serif; TEXT-ALIGN: left; MARGIN-LEFT: 18pt">Non-accelerated filer&#160; <font style="FONT-SIZE: 10pt; FONT-FAMILY: 'Wingdings 2', serif">&#163;</font> (Do not check if a smaller reporting company)</div>
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<div style="FONT-SIZE: 10pt; FONT-FAMILY: 'Times New Roman', Times, serif; TEXT-ALIGN: left">Smaller reporting company <font style="FONT-SIZE: 10pt; FONT-FAMILY: 'Wingdings 2', serif">&#163;</font></div>
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<tr>
<td style="WIDTH: 60%; VERTICAL-ALIGN: top">&#160;</td>
<td style="WIDTH: 40%; VERTICAL-ALIGN: top">
<div style="FONT-SIZE: 10pt; FONT-FAMILY: 'Times New Roman', Times, serif; TEXT-ALIGN: left">Emerging growth company <font style="FONT-SIZE: 10pt; FONT-FAMILY: 'Wingdings 2', serif">&#163;</font></div>
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<div style="FONT-SIZE: 10pt; TEXT-ALIGN: left; MARGIN-TOP: 6pt; TEXT-INDENT: 18pt">&#160;</div>

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<td style="FONT-SIZE: 10pt; WIDTH: 99.94%; VERTICAL-ALIGN: bottom">
<div style="FONT-FAMILY: 'Times New Roman', Times, serif; TEXT-ALIGN: left; TEXT-INDENT: 18pt">If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 7(a)(2)(B) of the Securities Act.&#160; <font style="FONT-FAMILY: 'Wingdings 2', serif">&#163;</font></div>
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<td style="FONT-SIZE: 10pt; WIDTH: 0.06%; VERTICAL-ALIGN: bottom">&#160;</td>
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<div style="MARGIN-BOTTOM: 6pt; FONT-SIZE: 11pt; FONT-WEIGHT: bold; TEXT-ALIGN: center">CALCULATION OF REGISTRATION FEE</div>

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<div style="FONT-SIZE: 10pt; FONT-FAMILY: 'Times New Roman', Times, serif; TEXT-ALIGN: center"><font style="FONT-SIZE: 11pt">Title of</font><font style="FONT-SIZE: 10pt; FONT-FAMILY: 'Times New Roman', Times, serif"><br>
</font><font style="FONT-SIZE: 11pt">Securities to be Registered <sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">(1)</sup></font></div>
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<div style="FONT-FAMILY: 'Times New Roman', Times, serif; TEXT-ALIGN: center">Amount to be Registered</div>
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<div style="FONT-SIZE: 10pt; FONT-FAMILY: 'Times New Roman', Times, serif; TEXT-ALIGN: center"><font style="FONT-SIZE: 11pt">Proposed</font><font style="FONT-SIZE: 10pt; FONT-FAMILY: 'Times New Roman', Times, serif"><br>
</font><font style="FONT-SIZE: 11pt">Maximum</font><font style="FONT-SIZE: 10pt; FONT-FAMILY: 'Times New Roman', Times, serif"><br>
</font><font style="FONT-SIZE: 11pt">Offering Price</font><font style="FONT-SIZE: 10pt; FONT-FAMILY: 'Times New Roman', Times, serif"><br>
</font><font style="FONT-SIZE: 11pt">Per Share</font></div>
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<td style="BORDER-TOP: #000000 2px solid; BORDER-RIGHT: #000000 2px solid; WIDTH: 16.78%; VERTICAL-ALIGN: bottom; BORDER-BOTTOM: #000000 4px double">
<div style="FONT-SIZE: 10pt; FONT-FAMILY: 'Times New Roman', Times, serif; TEXT-ALIGN: center"><font style="FONT-SIZE: 11pt">Proposed</font><font style="FONT-SIZE: 10pt; FONT-FAMILY: 'Times New Roman', Times, serif"><br>
</font><font style="FONT-SIZE: 11pt">Maximum</font><font style="FONT-SIZE: 10pt; FONT-FAMILY: 'Times New Roman', Times, serif"><br>
</font><font style="FONT-SIZE: 11pt">Aggregate</font><font style="FONT-SIZE: 10pt; FONT-FAMILY: 'Times New Roman', Times, serif"><br>
</font><font style="FONT-SIZE: 11pt">Offering Price</font></div>
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<div style="FONT-FAMILY: 'Times New Roman', Times, serif; TEXT-ALIGN: center">Amount of Registration Fee</div>
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<div style="FONT-FAMILY: 'Times New Roman', Times, serif; TEXT-ALIGN: left; MARGIN-LEFT: 12pt; TEXT-INDENT: -12pt">Ordinary Shares, $0.01 nominal value</div>
</td>
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<div style="FONT-FAMILY: 'Times New Roman', Times, serif; TEXT-ALIGN: center">5,000,000<sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">(2)</sup></div>
</td>
<td style="FONT-SIZE: 11pt; BORDER-RIGHT: #000000 2px solid; WIDTH: 15.02%; VERTICAL-ALIGN: top; BORDER-BOTTOM: #000000 2px solid">
<div style="FONT-FAMILY: 'Times New Roman', Times, serif; TEXT-ALIGN: center">$10.85<sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">(3)</sup></div>
</td>
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<div style="FONT-FAMILY: 'Times New Roman', Times, serif; TEXT-ALIGN: center">$54,250,000<sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">(3)</sup></div>
</td>
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<div style="FONT-FAMILY: 'Times New Roman', Times, serif; TEXT-ALIGN: center">$6,287.58<sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">(3)</sup></div>
</td>
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<div style="TEXT-ALIGN: justify">
<table id="9afa1a6e9f16428a8ac3c2d78d1f63e1" class="DSPFListTable" style="FONT-SIZE: 11pt; FONT-FAMILY: 'Times New Roman', Times, serif; WIDTH: 100%" cellspacing="0" cellpadding="0">
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<td style="FONT-SIZE: 10pt; FONT-FAMILY: 'Times New Roman', Times, serif; WIDTH: 18pt; VERTICAL-ALIGN: top; align: right">(1)</td>
<td style="FONT-SIZE: 10pt; FONT-FAMILY: 'Times New Roman', Times, serif; WIDTH: auto; VERTICAL-ALIGN: top; TEXT-ALIGN: justify">Each Ordinary Share is represented by one American Depositary Share ("ADS").</td>
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<div style="TEXT-ALIGN: left">
<table id="9695374d95954fcb826865ff9967e25f" class="DSPFListTable" style="FONT-SIZE: 11pt; FONT-FAMILY: 'Times New Roman', Times, serif; WIDTH: 100%" cellspacing="0" cellpadding="0">
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<td style="FONT-SIZE: 10pt; FONT-FAMILY: 'Times New Roman', Times, serif; WIDTH: 18pt; VERTICAL-ALIGN: top; align: right">(2)</td>
<td style="FONT-SIZE: 10pt; FONT-FAMILY: 'Times New Roman', Times, serif; WIDTH: auto; VERTICAL-ALIGN: top; TEXT-ALIGN: left">Represents 4,000,000 ordinary shares, $0.01 nominal value each, of Avadel Pharmaceuticals plc (the "Registrant") to be offered pursuant to the Registrant's 2017 Omnibus Incentive Compensation Plan, and 1,000,000 ordinary shares, $0.01 nominal value each, of the Registrant to be offered pursuant to the Registrant's 2017 Employee Share Purchase Plan. Pursuant to Rule 416(a) under the Securities Act of 1933, this Registration Statement also covers an indeterminate number of additional ordinary shares, $0.01 nominal value each, of the Registrant, which may be offered and issued to prevent dilution resulting from adjustments as a result of stock dividends, stock splits, reverse stock splits, recapitalizations, reclassifications, mergers, split-ups, reorganizations, consolidations and other capital adjustments.</td>
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</div>

<div style="TEXT-ALIGN: left">
<table id="82c684ab043647a0beeba98e82b862c8" class="DSPFListTable" style="FONT-SIZE: 11pt; FONT-FAMILY: 'Times New Roman', Times, serif; WIDTH: 100%" cellspacing="0" cellpadding="0">
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<td style="FONT-SIZE: 10pt; FONT-FAMILY: 'Times New Roman', Times, serif; WIDTH: 18pt; VERTICAL-ALIGN: top; align: right">(3)</td>
<td style="FONT-SIZE: 10pt; FONT-FAMILY: 'Times New Roman', Times, serif; WIDTH: auto; VERTICAL-ALIGN: top; TEXT-ALIGN: left">Estimated solely for the purpose of calculating the registration fee and computed in accordance with Rule 457(c) and (h)&#160;under the Securities Act of 1933, using the average of the high and low sale prices of the ADSs of the Registrant as reported on The NASDAQ Global Market on June 26, 2017, which was $10.85 per share.</td>
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<div style="MARGIN-BOTTOM: 6pt; FONT-SIZE: 11pt; FONT-FAMILY: 'Times New Roman', Times, serif; FONT-WEIGHT: bold; TEXT-ALIGN: center">PART I</div>

<div style="MARGIN-BOTTOM: 6pt; FONT-SIZE: 11pt; FONT-FAMILY: 'Times New Roman', Times, serif; FONT-WEIGHT: bold; TEXT-ALIGN: center">INFORMATION REQUIRED IN THE SECTION 10(a) PROSPECTUS</div>

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<div style="FONT-FAMILY: 'Times New Roman', Times, serif; FONT-WEIGHT: bold; TEXT-ALIGN: justify">ITEM 1.</div>
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<div style="FONT-FAMILY: 'Times New Roman', Times, serif; FONT-WEIGHT: bold; TEXT-ALIGN: justify; LINE-HEIGHT: normal"><font style="FONT-SIZE: 11pt; FONT-FAMILY: 'Times New Roman', Times, serif; FONT-VARIANT: normal; FONT-WEIGHT: bold; FONT-STYLE: normal"><u>Plan Information</u></font>.</div>
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<div style="FONT-FAMILY: 'Times New Roman', Times, serif; TEXT-ALIGN: justify">Not required to be filed with this Registration Statement.</div>

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<div style="FONT-FAMILY: 'Times New Roman', Times, serif; FONT-WEIGHT: bold; TEXT-ALIGN: justify">ITEM 2.</div>
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<div style="FONT-FAMILY: 'Times New Roman', Times, serif; FONT-WEIGHT: bold; TEXT-ALIGN: justify"><font style="FONT-SIZE: 11pt; FONT-FAMILY: 'Times New Roman', Times, serif; FONT-VARIANT: normal; FONT-WEIGHT: bold; FONT-STYLE: normal"><u>Registrant Information and Employee Plan Annual Information</u></font>.</div>

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<div style="FONT-FAMILY: 'Times New Roman', Times, serif; TEXT-ALIGN: justify">Not required to be filed with this Registration Statement.</div>
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<div style="MARGIN-BOTTOM: 6pt; FONT-SIZE: 11pt; FONT-FAMILY: 'Times New Roman', Times, serif; FONT-WEIGHT: bold; TEXT-ALIGN: center">PART II</div>

<div style="MARGIN-BOTTOM: 6pt; FONT-SIZE: 11pt; FONT-FAMILY: 'Times New Roman', Times, serif; FONT-WEIGHT: bold; TEXT-ALIGN: center">INFORMATION REQUIRED IN THE REGISTRATION STATEMENT</div>

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<div style="FONT-FAMILY: 'Times New Roman', Times, serif; FONT-WEIGHT: bold; TEXT-ALIGN: justify">ITEM 3.</div>
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<div style="FONT-FAMILY: 'Times New Roman', Times, serif; FONT-WEIGHT: bold; TEXT-ALIGN: justify"><font style="FONT-SIZE: 11pt; FONT-FAMILY: 'Times New Roman', Times, serif; FONT-VARIANT: normal; FONT-WEIGHT: bold; FONT-STYLE: normal"><u>Incorporation of Documents by Reference</u></font>.</div>

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<div style="MARGIN-BOTTOM: 6pt; FONT-SIZE: 11pt; FONT-FAMILY: 'Times New Roman', Times, serif; TEXT-ALIGN: left; TEXT-INDENT: 58pt">The Registrant hereby incorporates by reference into this Registration Statement the following documents previously filed by the Registrant with the Securities and Exchange Commission (the "Commission"):</div>

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<div style="MARGIN-BOTTOM: 6pt; FONT-FAMILY: 'Times New Roman', Times, serif; TEXT-ALIGN: justify">The Registrant's Annual Report on Form 10-K (File No. 001-37977) for the year ended December 31, 2016, <font style="FONT-FAMILY: 'Times New Roman', Times, serif; COLOR: #000000">filed with the Commission on March 28, 2017.</font></div>
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<div style="MARGIN-BOTTOM: 6pt; FONT-FAMILY: 'Times New Roman', Times, serif; TEXT-ALIGN: justify">The Registrant's Quarterly Report on Form 10-Q (File No. 001-37977) for the quarterly period ended March 31, 2017, <font style="FONT-FAMILY: 'Times New Roman', Times, serif; COLOR: #000000">filed with the Commission on May 10, 2017.</font></div>
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<div style="MARGIN-BOTTOM: 6pt; FONT-FAMILY: 'Times New Roman', Times, serif; TEXT-ALIGN: justify">The Registrant's Current Reports on Form 8-K (File No. 001-37977) filed with the Commission on March 31, 2017, April 7, 2017, April 18, 2017, April 25, 2017, May 1, 2017, May 18, 2017, May 26, 2017, and May 30, 2017.</div>
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<div style="MARGIN-BOTTOM: 6pt; FONT-FAMILY: 'Times New Roman', Times, serif; TEXT-ALIGN: justify">The description of the Registrant's ordinary shares, $0.01 nominal value each (the "Ordinary Shares"), set forth under the caption "Description of Share Capital" beginning on page 13 of the Registrant's post-effective amendment No. 2 to Form F-3 on Form S-3 (Registration No. 333-183961) filed with the Commission on January 6, 2017 (the "Registrant's January 2017 Form S-3 Amendment"), including any amendments or reports filed for the purpose of updating such description.</div>
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<div style="MARGIN-BOTTOM: 6pt; FONT-FAMILY: 'Times New Roman', Times, serif; TEXT-ALIGN: justify">The description of the Registrant's American Depositary Shares set forth under the caption "Description of American Depositary Shares" beginning on page 27 of the Registrant's January 2017 Form S-3 Amendment, including any amendments or reports filed for the purpose of updating such description.</div>
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<div style="MARGIN-BOTTOM: 6pt; FONT-SIZE: 11pt; FONT-FAMILY: 'Times New Roman', Times, serif; TEXT-ALIGN: left; TEXT-INDENT: 58pt">All documents that the Registrant subsequently files pursuant to Sections 13(a), 13(c), 14 and 15(d) of the Securities and Exchange Act of 1934, as amended, prior to the filing of a post-effective amendment to this Registration Statement which indicates that all of the Ordinary Shares offered have been sold or which deregisters all of such Ordinary Shares then remaining unsold, shall be deemed to be incorporated by reference in this Registration Statement and to be a part hereof from the date of the filing of such documents.</div>

<div style="MARGIN-BOTTOM: 6pt; FONT-SIZE: 11pt; FONT-FAMILY: 'Times New Roman', Times, serif; TEXT-ALIGN: left; TEXT-INDENT: 58pt">Any statement contained in a document incorporated or deemed to be incorporated by reference herein shall be deemed to be modified or superseded to the extent that a statement contained herein or in any other subsequently filed document which also is or is deemed to be incorporated by reference herein modifies or supersedes such statement. Any such statement so modified or superseded shall not be deemed, except as so modified or superseded, to constitute a part of this Registration Statement.</div>

<div style="MARGIN-BOTTOM: 6pt; FONT-SIZE: 11pt; FONT-FAMILY: 'Times New Roman', Times, serif; TEXT-ALIGN: left; TEXT-INDENT: 58pt">Notwithstanding the above, information that is "furnished to" the Commission shall not be deemed "filed with" the Commission and shall not be deemed incorporated by reference into this Registration Statement.</div>

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<div style="FONT-FAMILY: 'Times New Roman', Times, serif; FONT-WEIGHT: bold; TEXT-ALIGN: left"><font style="FONT-FAMILY: 'Times New Roman', Times, serif"><u>Description of Securities</u></font>.</div>

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<div style="FONT-FAMILY: 'Times New Roman', Times, serif; FONT-WEIGHT: bold; TEXT-ALIGN: left"><font style="FONT-FAMILY: 'Times New Roman', Times, serif"><u>Interests of Named Experts and Counsel</u></font>.</div>

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<div style="FONT-FAMILY: 'Times New Roman', Times, serif; FONT-WEIGHT: bold; TEXT-ALIGN: left"><font style="FONT-FAMILY: 'Times New Roman', Times, serif"><u>Indemnification of Directors and Officers</u></font>.</div>

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<div style="FONT-FAMILY: 'Times New Roman', Times, serif; FONT-WEIGHT: bold; TEXT-ALIGN: left">ITEM 6.</div>
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<div style="FONT-FAMILY: 'Times New Roman', Times, serif; FONT-WEIGHT: bold; TEXT-ALIGN: left"><font style="FONT-FAMILY: 'Times New Roman', Times, serif"><u>Indemnification of Directors and Officers</u></font>.</div>
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<div style="MARGIN-BOTTOM: 6pt; FONT-SIZE: 11pt; FONT-FAMILY: 'Times New Roman', Times, serif; COLOR: #000000; TEXT-ALIGN: left; BACKGROUND-COLOR: #ffffff; TEXT-INDENT: 58pt">If a director or officer of an Irish company is found to have breached his or her fiduciary duties to that company, he or she may be held personally liable to the company in respect of that breach of duty. The Registrant's constitution contains indemnification and expense advancement provisions for persons who are not directors, the secretary or assistant secretaries of the Registrant. The Registrant's constitution also (i) confers a more limited indemnity on its directors, secretary and assistant secretaries for certain costs, and (ii) discharges the liability of a director, the secretary or assistant secretary where judgment is found in favor of such director, secretary or assistant secretary in any civil or criminal action in respect of such costs or liability, or where an Irish court grants relief because the director, secretary or assistant secretary acted honestly and reasonably and ought fairly to be excused. This limitation does not apply to executives who are not directors, the secretary or assistant secretaries of the Registrant. Any provision which seeks to indemnify a director, secretary or assistant secretary of an Irish company over and above this shall be void under Irish law, whether contained in its constitution or any contract between the director and the company.</div>

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<div style="FONT-FAMILY: 'Times New Roman', Times, serif; FONT-WEIGHT: bold; TEXT-ALIGN: justify"><font style="FONT-FAMILY: 'Times New Roman', Times, serif"><u>Exemption from Registration Claimed</u></font>.</div>

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<div style="FONT-FAMILY: 'Times New Roman', Times, serif; FONT-WEIGHT: bold; TEXT-ALIGN: left"><font style="FONT-FAMILY: 'Times New Roman', Times, serif"><u>Exhibits</u></font>.</div>
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<div style="MARGIN-BOTTOM: 6pt; FONT-SIZE: 11pt; FONT-FAMILY: 'Times New Roman', Times, serif; TEXT-ALIGN: left; TEXT-INDENT: 58pt">Reference is made to the Exhibit Index on the page immediately preceding the exhibits for a list of exhibits filed as part of this Registration Statement, which Exhibit Index is incorporated herein by reference.</div>

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<div style="FONT-FAMILY: 'Times New Roman', Times, serif; FONT-WEIGHT: bold; TEXT-ALIGN: justify"><font style="FONT-FAMILY: 'Times New Roman', Times, serif"><u>Undertakings</u></font>.</div>

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<div style="TEXT-ALIGN: justify"><font style="FONT-FAMILY: 'Times New Roman', Times, serif">(a)</font><font id="TRGRRTFtoHTMLTab">&#160;&#160;&#160;&#160;&#160; </font><font style="FONT-FAMILY: 'Times New Roman', Times, serif">The undersigned Registrant hereby undertakes:</font></div>

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<div style="FONT-FAMILY: 'Times New Roman', Times, serif; TEXT-ALIGN: justify; TEXT-INDENT: 30pt">(1)&#160;&#160; To file, during any period in which offers or sales are being made, a post-effective amendment to the Registration Statement:</div>
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<div style="TEXT-ALIGN: justify; MARGIN-RIGHT: 36pt; TEXT-INDENT: 54pt"><font style="FONT-FAMILY: 'Times New Roman', Times, serif">(i)</font><font id="TRGRRTFtoHTMLTab">&#160;&#160;&#160;&#160;&#160;&#160;</font><font style="FONT-FAMILY: 'Times New Roman', Times, serif">to include any prospectus required by Section 10(a)(3) of the Securities Act,</font></div>

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<div style="TEXT-ALIGN: justify; MARGIN-RIGHT: 36pt; TEXT-INDENT: 54pt"><font style="FONT-FAMILY: 'Times New Roman', Times, serif">(ii)</font><font id="TRGRRTFtoHTMLTab">&#160;&#160;&#160;&#160;&#160;&#160;</font><font style="FONT-FAMILY: 'Times New Roman', Times, serif">to reflect in the prospectus any facts or events arising after the effective date of the Registration Statement (or the most recent post-effective amendment thereof) which, individually or in the aggregate, represent a fundamental change in the information set forth in the Registration Statement.&#160; Notwithstanding the foregoing, any increase or decrease in volume of securities offered (if the total dollar value of securities offered would not exceed that which was registered) and any deviation from the low or high end of the estimated maximum offering range may be reflected in the form of prospectus filed with the Commission pursuant to Rule 424(b) if, in the aggregate, the changes in volume and price represent no more than a 20 percent change in the maximum aggregate offering price set forth in the "Calculation of Registration fee" table in the effective Registration Statement; and</font></div>

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<div style="TEXT-ALIGN: justify; MARGIN-RIGHT: 36pt; TEXT-INDENT: 54pt"><font style="FONT-FAMILY: 'Times New Roman', Times, serif">(iii)</font><font id="TRGRRTFtoHTMLTab">&#160;&#160;&#160;&#160;&#160;&#160;</font><font style="FONT-FAMILY: 'Times New Roman', Times, serif">to include any material information with respect to the plan of distribution not previously disclosed in the Registration Statement or any material change to such information in the Registration Statement;</font></div>
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<div style="MARGIN-BOTTOM: 6pt; FONT-SIZE: 11pt; FONT-FAMILY: 'Times New Roman', Times, serif; TEXT-ALIGN: justify; TEXT-INDENT: 62pt">&#160;&#160;&#160;&#160;&#160; (3)&#160; To remove from registration by means of a post-effective amendment any of the securities being registered which remain unsold at the termination of the offering.</div>

<div style="MARGIN-BOTTOM: 6pt; FONT-SIZE: 11pt; TEXT-ALIGN: justify; TEXT-INDENT: 54pt"><font style="FONT-FAMILY: 'Times New Roman', Times, serif">(b)</font><font id="TRGRRTFtoHTMLTab">&#160;&#160;&#160;&#160;</font><font style="FONT-FAMILY: 'Times New Roman', Times, serif">The undersigned Registrant hereby undertakes that, for purposes of determining any liability under the Securities Act, each filing of the Registrant's annual report pursuant to Section 13(a) or Section&#160;15(d) of the Exchange Act (and, where applicable, each filing of an employee benefit plan's annual report pursuant to Section 15(d) of the Exchange Act) that is incorporated by reference into the Registration Statement shall be deemed to be a new Registration Statement relating to the securities offered therein, and the offering of such securities at that time shall be deemed to be the initial bona fide offering thereof.</font></div>

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<div style="FONT-SIZE: 11pt; FONT-FAMILY: 'Times New Roman', Times, serif; FONT-WEIGHT: bold; TEXT-ALIGN: center; MARGIN-TOP: 6pt">SIGNATURES</div>

<div style="FONT-SIZE: 11pt; FONT-FAMILY: 'Times New Roman', Times, serif; TEXT-ALIGN: justify; MARGIN-TOP: 6pt; TEXT-INDENT: 36pt">Pursuant to the requirements of the Securities Act of 1933, the Registrant certifies that it has reasonable grounds to believe that it meets all of the requirements for filing on Form S-8 and has duly caused this Registration Statement to be signed on its behalf by the undersigned, thereunto duly authorized, in the city of <font style="FONT-FAMILY: 'Times New Roman', Times, serif; COLOR: #000000">Chesterfield, Missouri, on June 28, 2017.</font></div>

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<div style="FONT-SIZE: 11pt; FONT-FAMILY: 'Times New Roman', Times, serif; FONT-WEIGHT: bold; TEXT-ALIGN: left">AVADEL PHARMACEUTICALS PLC</div>

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<div style="FONT-FAMILY: 'Times New Roman', Times, serif; TEXT-ALIGN: left">By:</div>
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<div style="FONT-FAMILY: 'Times New Roman', Times, serif; TEXT-ALIGN: left"><font style="FONT-FAMILY: 'Times New Roman', Times, serif">/s/ </font><font style="FONT-FAMILY: 'Times New Roman', Times, serif; COLOR: #000000">Michael S. Anderson</font></div>
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<div style="FONT-FAMILY: 'Times New Roman', Times, serif; COLOR: #000000; TEXT-ALIGN: left">Michael S. Anderson</div>
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<div style="FONT-FAMILY: 'Times New Roman', Times, serif; COLOR: #000000; TEXT-ALIGN: left">Chief Executive Officer</div>
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<div style="FONT-SIZE: 11pt; FONT-FAMILY: 'Times New Roman', Times, serif; FONT-WEIGHT: bold; TEXT-ALIGN: center; MARGIN-TOP: 6pt">POWER OF ATTORNEY</div>

<div style="FONT-SIZE: 11pt; FONT-FAMILY: 'Times New Roman', Times, serif; TEXT-ALIGN: justify; MARGIN-TOP: 6pt; TEXT-INDENT: 36pt">KNOW ALL PERSONS BY THESE PRESENTS, that each of <font style="FONT-FAMILY: 'Times New Roman', Times, serif; COLOR: #000000">Craig R. Stapleton, Francis J.T. Fildes, Benoit Van Assche, Christophe Navarre, and Peter Thornton </font>constitutes and appoints <font style="FONT-FAMILY: 'Times New Roman', Times, serif; COLOR: #000000">Michael S. Anderson and Phillandas T. Thompson</font>, and each of them, as his true and lawful attorney-in-fact and agent, upon the action of such appointee, with full power of substitution and resubstitution, to do any and all acts and things and execute, in the name of the undersigned, any and all instruments which each of said attorneys-in-fact and agents may deem necessary or advisable in order to enable Avadel Pharmaceuticals plc to comply with the Securities Act of 1933 (the "Securities Act") and any requirements of the Securities and Exchange Commission (the "Commission") in respect thereof in connection with the filing with the Commission of this Registration Statement on Form S-8 under the Securities Act, including specifically but without limitation, power and authority to sign the name of the undersigned to such Registration Statement, and any amendments to such Registration Statement (including post-effective amendments), and to file the same with all exhibits thereto and other documents in connection therewith, with the Commission, to sign any and all applications, Registration Statements, notices or other documents necessary or advisable to comply with applicable state securities laws, and to file the same, together with other documents in connection therewith with the appropriate state securities authorities, granting unto each of said attorneys-in-fact and agents full power and authority to do and to perform each and every act and thing requisite or necessary to be done in and about the premises, as fully and to all intents and purposes as the undersigned might or could do in person, hereby ratifying and confirming all that each of said attorneys-in-fact and agents may lawfully do or cause to be done by virtue hereof.</div>

<div style="FONT-SIZE: 11pt; FONT-FAMILY: 'Times New Roman', Times, serif; TEXT-ALIGN: justify; MARGIN-TOP: 6pt; TEXT-INDENT: 36pt">Pursuant to the requirements of the Securities Act, this Registration Statement has been signed by the following persons in the capacities and on the dates indicated.</div>

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<div style="FONT-SIZE: 11pt; FONT-FAMILY: 'Times New Roman', Times, serif; FONT-VARIANT: normal; FONT-WEIGHT: bold; FONT-STYLE: normal; TEXT-ALIGN: center"><u>Signature</u></div>

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<div style="FONT-SIZE: 11pt; FONT-FAMILY: 'Times New Roman', Times, serif; FONT-VARIANT: normal; FONT-WEIGHT: bold; FONT-STYLE: normal; TEXT-ALIGN: center"><u>Date</u></div>

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<div style="FONT-FAMILY: 'Times New Roman', Times, serif; TEXT-ALIGN: left; MARGIN-RIGHT: 13.5pt">/s/ <font style="FONT-FAMILY: 'Times New Roman', Times, serif; COLOR: #000000">Michael S. Anderson</font></div>
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<div style="FONT-FAMILY: 'Times New Roman', Times, serif; TEXT-ALIGN: left; MARGIN-RIGHT: 14.4pt">/s/ <font style="FONT-FAMILY: 'Times New Roman', Times, serif; COLOR: #000000">Michael F. Kanan</font></div>
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<div style="FONT-FAMILY: 'Times New Roman', Times, serif; TEXT-ALIGN: center; MARGIN-RIGHT: 14.4pt">C<font style="FONT-FAMILY: 'Times New Roman', Times, serif; COLOR: #000000">hief Financial Officer (Principal Financial&#160;Officer)</font></div>
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<div style="FONT-FAMILY: 'Times New Roman', Times, serif; COLOR: #000000; TEXT-ALIGN: left; MARGIN-RIGHT: 14.4pt">Michael F. Kanan</div>
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<div style="FONT-FAMILY: 'Times New Roman', Times, serif; TEXT-ALIGN: left; MARGIN-RIGHT: 14.4pt">/s/ <font style="FONT-FAMILY: 'Times New Roman', Times, serif; COLOR: #000000">David P. Gusky</font></div>
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<div style="FONT-FAMILY: 'Times New Roman', Times, serif; COLOR: #000000; TEXT-ALIGN: center; MARGIN-RIGHT: 14.4pt">Corporate Controller (Principal Accounting&#160;Officer)</div>
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<div style="FONT-FAMILY: 'Times New Roman', Times, serif; TEXT-ALIGN: left; MARGIN-RIGHT: 14.4pt">/s/ <font style="FONT-FAMILY: 'Times New Roman', Times, serif; COLOR: #000000">Benoit Van Assche</font></div>
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<div style="FONT-FAMILY: 'Times New Roman', Times, serif; TEXT-ALIGN: center; MARGIN-RIGHT: 14.4pt">June 28, 2017</div>
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<div style="FONT-FAMILY: 'Times New Roman', Times, serif; COLOR: #000000; TEXT-ALIGN: left; MARGIN-RIGHT: 14.4pt">Benoit Van Assche</div>
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<div style="FONT-FAMILY: 'Times New Roman', Times, serif; COLOR: #000000; TEXT-ALIGN: left; MARGIN-RIGHT: 14.4pt">Christophe Navarre</div>
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<div style="FONT-FAMILY: 'Times New Roman', Times, serif; TEXT-ALIGN: left; MARGIN-RIGHT: 14.4pt">/s/ <font style="FONT-FAMILY: 'Times New Roman', Times, serif; COLOR: #000000">Peter Thornton</font></div>
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<div style="FONT-SIZE: 11pt; FONT-FAMILY: 'Times New Roman', Times, serif; FONT-WEIGHT: bold; TEXT-ALIGN: center">INDEX TO EXHIBITS</div>

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</font><font style="FONT-SIZE: 11pt">Number</font></div>
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<div style="FONT-FAMILY: 'Times New Roman', Times, serif; COLOR: #000000; TEXT-ALIGN: justify">Constitution (containing the Memorandum and Articles of Association) of Avadel Pharmaceuticals plc<sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">(1)</sup></div>
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<div style="FONT-FAMILY: 'Times New Roman', Times, serif; TEXT-ALIGN: center"><a href="ex5_1-s806282017.htm">5.1</a></div>
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<div style="FONT-FAMILY: 'Times New Roman', Times, serif; COLOR: #000000; TEXT-ALIGN: justify"><a href="ex5_1-s806282017.htm">Opinion of Arthur Cox, Solicitors</a></div>

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<div style="FONT-FAMILY: 'Times New Roman', Times, serif; COLOR: #000000; TEXT-ALIGN: justify"><a href="ex23_2.htm">Consent of Deloitte &amp; Touche LLP</a></div>

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<div style="FONT-FAMILY: 'Times New Roman', Times, serif; TEXT-ALIGN: justify">Consent of <font style="FONT-FAMILY: 'Times New Roman', Times, serif; COLOR: #000000">Arthur Cox, Solicitors</font><sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">(2)</sup></div>
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<td style="FONT-SIZE: 11pt; WIDTH: 84.93%; VERTICAL-ALIGN: top">
<div style="FONT-FAMILY: 'Times New Roman', Times, serif; TEXT-ALIGN: justify">2017 Omnibus Incentive Compensation Plan<sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">(3)</sup></div>
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<div style="FONT-FAMILY: 'Times New Roman', Times, serif; TEXT-ALIGN: justify">2017 Employee Share Purchase Plan<sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">(4)</sup></div>
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<div style="FONT-SIZE: 11pt; FONT-FAMILY: 'Times New Roman', Times, serif; TEXT-ALIGN: left">_________________________________</div>

<div style="FONT-SIZE: 11pt; FONT-FAMILY: 'Times New Roman', Times, serif; TEXT-ALIGN: left">(1) <font style="FONT-FAMILY: 'Times New Roman', Times, serif; COLOR: #000000">Incorporated by reference to Appendix 15 of Exhibit 2.1 to the Registrant's current report on Form 8-K, filed with the Commission on July 1, 2016.</font></div>

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<div style="FONT-SIZE: 11pt; FONT-FAMILY: 'Times New Roman', Times, serif; COLOR: #000000; TEXT-ALIGN: left">(2) Included in Exhibit 5.1.</div>

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<div style="FONT-SIZE: 11pt; FONT-FAMILY: 'Times New Roman', Times, serif; COLOR: #000000; TEXT-ALIGN: left">(3) Incorporated by reference to Annex A of the definitive Proxy Statement of the Registrant on Schedule 14A filed with the Commission on May 1, 2017.</div>

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<div style="FONT-SIZE: 11pt; FONT-FAMILY: 'Times New Roman', Times, serif; COLOR: #000000; TEXT-ALIGN: left">(4) Incorporated by reference to Annex B of the definitive Proxy Statement of the Registrant on Schedule 14A filed with the Commission on May 1, 2017.</div>

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[{"type": "S-8", "sequence": "1", "filename": "fs8-06282017.htm", "description": "FORM S-8", "secsgml_size_bytes": 78337}]
{"company-data": {"conformed-name": "AVADEL PHARMACEUTICALS PLC", "cik": "0001012477", "assigned-sic": "2834", "irs-number": "000000000", "fiscal-year-end": "1231"}, "filing-values": {"form-type": "S-8", "act": "33", "file-number": "333-219016", "film-number": "17935478"}, "business-address": {"street1": "BLOCK 10-1 BLANCHARDSTOWN CORPORATE PARK", "street2": "BALLYCOOLIN", "city": "DUBLIN", "state": "L2", "zip": "15", "phone": "636-449-1830"}, "mail-address": {"street1": "16640 CHESTERFIELD GROVE ROAD", "street2": "SUITE 200", "city": "CHESTERFIELD", "state": "MO", "zip": "63005"}, "former-company": {"former-conformed-name": "FLAMEL TECHNOLOGIES SA", "date-changed": "19960422"}}
As filed with the Securities and Exchange Commission on June 28, 2017
Registration No. 333-
UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
________________
FORM S-8
REGISTRATION STATEMENT
UNDER THE SECURITIES ACT OF 1933
________________
AVADEL PHARMACEUTICALS PLC
(Exact name of Registrant as specified in its charter)
Ireland
98-1341933
(State or other jurisdiction of incorporation or organization)
(I.R.S. Employer Identification No.)
Block 10-1
Blanchardstown Corporate Park, Ballycoolin
Dublin 15, Ireland
Not Applicable
(Address of Principal Executive Offices)
(Zip Code)
________________
2017 Omnibus Incentive Compensation Plan
2017 Employee Share Purchase Plan
(Full title of the plans)
Phillandas T. Thompson, Esq.
Avadel Pharmaceuticals plc
16640 Chesterfield Grove Road
Suite 200
Chesterfield, MO 63005
(Name and address of agent for service)
(636) 449-1840
(Telephone number, including area code, of agent for service)
________________
Copies of all correspondence to:
Timothy I Kahler, Esq.
Christopher McLaughlin, Esq.
Joseph Walsh, Esq.
Arthur Cox
Troutman Sanders LLP
Ten Earlsfort Terrace
875 Third Avenue
Dublin 2, Ireland
New York, NY 10022
+353 1 618 0000
(212) 704-6000
________________
Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, a smaller reporting company or an emerging growth company. See the definitions of "large accelerated filer," "accelerated filer," "smaller reporting company," and "emerging growth company" in Rule 12b-2 of the Exchange Act.
Large accelerated filer
£
Accelerated filer
S
Non-accelerated filer
£
(Do not check if a smaller reporting company)
Smaller reporting company
£
Emerging growth company
£
If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 7(a)(2)(B) of the Securities Act.
£
CALCULATION OF REGISTRATION FEE
Title of
Securities to be Registered
(1)
Amount to be Registered
Proposed
Maximum
Offering Price
Per Share
Proposed
Maximum
Aggregate
Offering Price
Amount of Registration Fee
Ordinary Shares, $0.01 nominal value
5,000,000
(2)
$10.85
(3)
$54,250,000
(3)
$6,287.58
(3)
(1)
Each Ordinary Share is represented by one American Depositary Share ("ADS").
(2)
Represents 4,000,000 ordinary shares, $0.01 nominal value each, of Avadel Pharmaceuticals plc (the "Registrant") to be offered pursuant to the Registrant's 2017 Omnibus Incentive Compensation Plan, and 1,000,000 ordinary shares, $0.01 nominal value each, of the Registrant to be offered pursuant to the Registrant's 2017 Employee Share Purchase Plan. Pursuant to Rule 416(a) under the Securities Act of 1933, this Registration Statement also covers an indeterminate number of additional ordinary shares, $0.01 nominal value each, of the Registrant, which may be offered and issued to prevent dilution resulting from adjustments as a result of stock dividends, stock splits, reverse stock splits, recapitalizations, reclassifications, mergers, split-ups, reorganizations, consolidations and other capital adjustments.
(3)
Estimated solely for the purpose of calculating the registration fee and computed in accordance with Rule 457(c) and (h) under the Securities Act of 1933, using the average of the high and low sale prices of the ADSs of the Registrant as reported on The NASDAQ Global Market on June 26, 2017, which was $10.85 per share.
PART I
INFORMATION REQUIRED IN THE SECTION 10(a) PROSPECTUS
ITEM 1.
Plan Information
.
Not required to be filed with this Registration Statement.
ITEM 2.
Registrant Information and Employee Plan Annual Information
.
Not required to be filed with this Registration Statement.
PART II
INFORMATION REQUIRED IN THE REGISTRATION STATEMENT
ITEM 3.
Incorporation of Documents by Reference
.
The Registrant hereby incorporates by reference into this Registration Statement the following documents previously filed by the Registrant with the Securities and Exchange Commission (the "Commission"):
·
The Registrant's Annual Report on Form 10-K (File No. 001-37977) for the year ended December 31, 2016,
filed with the Commission on March 28, 2017.
·
The Registrant's Quarterly Report on Form 10-Q (File No. 001-37977) for the quarterly period ended March 31, 2017,
filed with the Commission on May 10, 2017.
·
The Registrant's Current Reports on Form 8-K (File No. 001-37977) filed with the Commission on March 31, 2017, April 7, 2017, April 18, 2017, April 25, 2017, May 1, 2017, May 18, 2017, May 26, 2017, and May 30, 2017.
·
The description of the Registrant's ordinary shares, $0.01 nominal value each (the "Ordinary Shares"), set forth under the caption "Description of Share Capital" beginning on page 13 of the Registrant's post-effective amendment No. 2 to Form F-3 on Form S-3 (Registration No. 333-183961) filed with the Commission on January 6, 2017 (the "Registrant's January 2017 Form S-3 Amendment"), including any amendments or reports filed for the purpose of updating such description.
·
The description of the Registrant's American Depositary Shares set forth under the caption "Description of American Depositary Shares" beginning on page 27 of the Registrant's January 2017 Form S-3 Amendment, including any amendments or reports filed for the purpose of updating such description.
All documents that the Registrant subsequently files pursuant to Sections 13(a), 13(c), 14 and 15(d) of the Securities and Exchange Act of 1934, as amended, prior to the filing of a post-effective amendment to this Registration Statement which indicates that all of the Ordinary Shares offered have been sold or which deregisters all of such Ordinary Shares then remaining unsold, shall be deemed to be incorporated by reference in this Registration Statement and to be a part hereof from the date of the filing of such documents.
Any statement contained in a document incorporated or deemed to be incorporated by reference herein shall be deemed to be modified or superseded to the extent that a statement contained herein or in any other subsequently filed document which also is or is deemed to be incorporated by reference herein modifies or supersedes such statement. Any such statement so modified or superseded shall not be deemed, except as so modified or superseded, to constitute a part of this Registration Statement.
Notwithstanding the above, information that is "furnished to" the Commission shall not be deemed "filed with" the Commission and shall not be deemed incorporated by reference into this Registration Statement.
ITEM 4.
Description of Securities
.
Not applicable.
ITEM 5.
Interests of Named Experts and Counsel
.
Not applicable.
ITEM 6.
Indemnification of Directors and Officers
.
ITEM 6.
Indemnification of Directors and Officers
.
If a director or officer of an Irish company is found to have breached his or her fiduciary duties to that company, he or she may be held personally liable to the company in respect of that breach of duty. The Registrant's constitution contains indemnification and expense advancement provisions for persons who are not directors, the secretary or assistant secretaries of the Registrant. The Registrant's constitution also (i) confers a more limited indemnity on its directors, secretary and assistant secretaries for certain costs, and (ii) discharges the liability of a director, the secretary or assistant secretary where judgment is found in favor of such director, secretary or assistant secretary in any civil or criminal action in respect of such costs or liability, or where an Irish court grants relief because the director, secretary or assistant secretary acted honestly and reasonably and ought fairly to be excused. This limitation does not apply to executives who are not directors, the secretary or assistant secretaries of the Registrant. Any provision which seeks to indemnify a director, secretary or assistant secretary of an Irish company over and above this shall be void under Irish law, whether contained in its constitution or any contract between the director and the company.
Under Irish law, a company may not exempt its directors from liability for negligence or a breach of duty. However, where a breach of duty has been established, directors may be exempted by an Irish court from personal liability for negligence or breach of duty if, among other things, the court determines that they have acted honestly and reasonably, and that they may fairly be excused as a result.
Irish companies may take out directors' and officers' liability insurance, as well as other types of insurance, for their directors and officers. The Registrant has taken out directors' and officers' liability insurance, as well as other types of insurance, for its directors and officers.
ITEM 7.
Exemption from Registration Claimed
.
Not applicable.
ITEM 8
Exhibits
.
Reference is made to the Exhibit Index on the page immediately preceding the exhibits for a list of exhibits filed as part of this Registration Statement, which Exhibit Index is incorporated herein by reference.
ITEM 9.
Undertakings
.
(a)
The undersigned Registrant hereby undertakes:
(1)   To file, during any period in which offers or sales are being made, a post-effective amendment to the Registration Statement:
(i)
to include any prospectus required by Section 10(a)(3) of the Securities Act,
(ii)
to reflect in the prospectus any facts or events arising after the effective date of the Registration Statement (or the most recent post-effective amendment thereof) which, individually or in the aggregate, represent a fundamental change in the information set forth in the Registration Statement.  Notwithstanding the foregoing, any increase or decrease in volume of securities offered (if the total dollar value of securities offered would not exceed that which was registered) and any deviation from the low or high end of the estimated maximum offering range may be reflected in the form of prospectus filed with the Commission pursuant to Rule 424(b) if, in the aggregate, the changes in volume and price represent no more than a 20 percent change in the maximum aggregate offering price set forth in the "Calculation of Registration fee" table in the effective Registration Statement; and
(iii)
to include any material information with respect to the plan of distribution not previously disclosed in the Registration Statement or any material change to such information in the Registration Statement;
provided, however,
that paragraphs (1)(i) and (1)(ii) shall not apply if the information required to be included in a post-effective amendment by those clauses is contained in periodic reports filed with or furnished to the Commission by the Registrant pursuant to Section 13 or Section 15(d) of the Exchange Act that are incorporated by reference into the Registration Statement;
(2)  That, for the purpose of determining any liability under the Securities Act, each such post-effective amendment shall be deemed to be a new Registration Statement relating to the securities offered therein, and the offering of such securities at that time shall be deemed to be the initial bona fide offering thereof; and
(3)  To remove from registration by means of a post-effective amendment any of the securities being registered which remain unsold at the termination of the offering.
(b)
The undersigned Registrant hereby undertakes that, for purposes of determining any liability under the Securities Act, each filing of the Registrant's annual report pursuant to Section 13(a) or Section 15(d) of the Exchange Act (and, where applicable, each filing of an employee benefit plan's annual report pursuant to Section 15(d) of the Exchange Act) that is incorporated by reference into the Registration Statement shall be deemed to be a new Registration Statement relating to the securities offered therein, and the offering of such securities at that time shall be deemed to be the initial bona fide offering thereof.
(c)
Insofar as indemnification for liabilities arising under the Securities Act may be permitted to directors, officers and controlling persons of the Registrant pursuant to the indemnification provisions summarized in Item 6 above, or otherwise, the Registrant has been advised that in the opinion of the Commission such indemnification is against public policy as expressed in the Securities Act and is, therefore, unenforceable.  In the event that a claim for indemnification against such liabilities (other than the payment by the Registrant of expenses incurred or paid by a director, officer or controlling person of the Registrant in the successful defense of any action, suit or proceeding) is asserted by such director, officer or controlling person in connection with the securities being registered, the Registrant will, unless in the opinion of its counsel the matter has been settled by controlling precedent, submit to a court of appropriate jurisdiction the question whether such indemnification by it is against public policy as expressed in the Securities Act and will be governed by the final adjudication of such issue.
SIGNATURES
Pursuant to the requirements of the Securities Act of 1933, the Registrant certifies that it has reasonable grounds to believe that it meets all of the requirements for filing on Form S-8 and has duly caused this Registration Statement to be signed on its behalf by the undersigned, thereunto duly authorized, in the city of
Chesterfield, Missouri, on June 28, 2017.
AVADEL PHARMACEUTICALS PLC
By:
/s/
Michael S. Anderson
Michael S. Anderson
Chief Executive Officer
POWER OF ATTORNEY
KNOW ALL PERSONS BY THESE PRESENTS, that each of
Craig R. Stapleton, Francis J.T. Fildes, Benoit Van Assche, Christophe Navarre, and Peter Thornton
constitutes and appoints
Michael S. Anderson and Phillandas T. Thompson
, and each of them, as his true and lawful attorney-in-fact and agent, upon the action of such appointee, with full power of substitution and resubstitution, to do any and all acts and things and execute, in the name of the undersigned, any and all instruments which each of said attorneys-in-fact and agents may deem necessary or advisable in order to enable Avadel Pharmaceuticals plc to comply with the Securities Act of 1933 (the "Securities Act") and any requirements of the Securities and Exchange Commission (the "Commission") in respect thereof in connection with the filing with the Commission of this Registration Statement on Form S-8 under the Securities Act, including specifically but without limitation, power and authority to sign the name of the undersigned to such Registration Statement, and any amendments to such Registration Statement (including post-effective amendments), and to file the same with all exhibits thereto and other documents in connection therewith, with the Commission, to sign any and all applications, Registration Statements, notices or other documents necessary or advisable to comply with applicable state securities laws, and to file the same, together with other documents in connection therewith with the appropriate state securities authorities, granting unto each of said attorneys-in-fact and agents full power and authority to do and to perform each and every act and thing requisite or necessary to be done in and about the premises, as fully and to all intents and purposes as the undersigned might or could do in person, hereby ratifying and confirming all that each of said attorneys-in-fact and agents may lawfully do or cause to be done by virtue hereof.
Pursuant to the requirements of the Securities Act, this Registration Statement has been signed by the following persons in the capacities and on the dates indicated.
Signature
Title
Date
/s/
Michael S. Anderson
Chief Executive Officer (Principal Executive Officer) and Director
June 28, 2017
Michael S. Anderson
/s/
Michael F. Kanan
C
hief Financial Officer (Principal Financial Officer)
June 28, 2017
Michael F. Kanan
/s/
David P. Gusky
Corporate Controller (Principal Accounting Officer)
June 28, 2017
David P. Gusky
Non-Executive Chairman of the Board and Director
Craig R. Stapleton
/s/
Francis J.T. Fildes
Director
June 28, 2017
Francis J.T. Fildes
/s/
Benoit Van Assche
Director
June 28, 2017
Benoit Van Assche
Director
Christophe Navarre
/s/
Peter Thornton
Director
June 28, 2017
Peter Thornton
INDEX TO EXHIBITS
Exhibit
Number
Description
3.1
Constitution (containing the Memorandum and Articles of Association) of Avadel Pharmaceuticals plc
(1)
5.1
Opinion of Arthur Cox, Solicitors
23.1
Consent of PricewaterhouseCoopers Audit
23.2
Consent of Deloitte & Touche LLP
23.3
Consent of
Arthur Cox, Solicitors
(2)
24.1
Power of Attorney (included on signature page)
99.1
2017 Omnibus Incentive Compensation Plan
(3)
99.2
2017 Employee Share Purchase Plan
(4)
_________________________________
(1)
Incorporated by reference to Appendix 15 of Exhibit 2.1 to the Registrant's current report on Form 8-K, filed with the Commission on July 1, 2016.
(2) Included in Exhibit 5.1.
(3) Incorporated by reference to Annex A of the definitive Proxy Statement of the Registrant on Schedule 14A filed with the Commission on May 1, 2017.
(4) Incorporated by reference to Annex B of the definitive Proxy Statement of the Registrant on Schedule 14A filed with the Commission on May 1, 2017.