As filed with the Securities and Exchange Commission on April 24, 2009
                                                          Registration No. 333-

--------------------------------------------------------------------------------
                       SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549

                                    FORM S-8
                             REGISTRATION STATEMENT
                                      UNDER
                           THE SECURITIES ACT OF 1933

                                 WESBANCO, INC.
             (Exact name of registrant as specified in its charter)

      West Virginia                                     55-0571723
(State or other jurisdiction of                       (IRS Employer
 incorporation or organization)                      Identification No.)
                                 One Bank Plaza
                          Wheeling, West Virginia 26003
                                 (304) 234-9000
       (Address, including zip code, and telephone number, including area
               code, of Registrant's principal executive offices)

                               WESBANCO, INC. KSOP
                            (Full title of the Plan)

                                 Paul M. Limbert
                      President and Chief Executive Officer
                                 WesBanco, Inc.
                                 One Bank Plaza
                          Wheeling, West Virginia 26003
                                 (304) 234-9000
 (Name, address, including zip code, and telephone number, including area code,
                              of agent for service)

                                                 Copies to:
James C. Gardill, Esq.                           Paul C. Cancilla, Esq.
Phillips, Gardill, Kaiser & Altmeyer, PLLC       K&L Gates LLP
61 Fourteenth Street                             Henry W. Oliver Building
Wheeling, WV 26003                               535 Smithfield Street
(304) 232-6810                                   Pittsburgh, PA 15222
                                                 (412) 355-6500


Indicate by check mark whether the registrant is a large  accelerated  filer, an
accelerated filer, a non-accelerated  filer or a smaller reporting company.  See
the definitions of "large accelerated  filer,"  "accelerated filer" and "smaller
reporting company" in Rule 12b-2 of the Exchange Act. (Check one):

<TABLE>
         <S>                          <C>                     <C>                        <C>

Large accelerated filer  / /   Accelerated filer |X|  Non-accelerated filer  / /   Smaller reporting
                                                     (Do not check if a smaller     company / /
                                                         reporting company)
</TABLE>


                         CALCULATION OF REGISTRATION FEE
<TABLE>
             <S>                      <C>          <C>             <C>                   <C>

-------------------------------- ------------- --------------- --------------- --------------------------
                                                 Proposed        Proposed
           Title of                               maximum         maximum       Amount of registration
          securities              Amount to      offering        aggregate                fee
       to be registered               be         price per       offering
                                 registered(1)    share(2)        price(2)
-------------------------------- ------------- --------------- --------------- --------------------------

Common Stock, $2.0833 par          750,000        $22.47         $16,852,500           $940.37
value per share

-------------------------------- ------------- --------------- --------------- --------------------------
</TABLE>


(1) This amount  represents a 750,000 share  increase in the number of shares of
the  Registrant's  common stock,  $2.0833 par value per share  ("Common  Stock")
authorized for issuance under the WesBanco, Inc. KSOP. In addition to the shares
set forth in the table,  pursuant to Rule  416(a)  under the  Securities  Act of
1933, as amended ("Securities Act"), this registration  statement also covers an
indeterminable number of shares of Common Stock that may be issuable as a result
of stock splits, stock dividends and anti-dilution provisions.

(2)  Estimated  solely  for the  purpose of  calculating  the  registration  fee
pursuant to Rule 457(h) and Rule 457(c)  under the  Securities  Act.  The fee is
calculated  on the  basis of the  average  of the high  and low  prices  for the
Registrant's  Common Stock  reported on the NASDAQ Global Select Market on April
21, 2009.


<PAGE>

                                TABLE OF CONTENTS

PART II
     Item 3.  Incorporation of Documents by Reference
     Item 5.  Interests of Named Experts and Counsel
     Item 8.  Exhibits
SIGNATURES
INDEX TO EXHIBITS
EX-5.1:  OPINION OF PHILLIPS, GARDILL, KAISER & ALTMEYER, PLLC
EX-23.1:  CONSENT OF INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRM



                                      II-1
<PAGE>


                                EXPLANATORY NOTE

     This  Registration  Statement on Form S-8 is being filed by WesBanco,  Inc.
("WesBanco")  to register an  additional  750,000  shares of  WesBanco's  common
stock,  par value of $2.0833 per share,  issuable under the WesBanco,  Inc. KSOP
(the  "Plan").   Pursuant  to  General  Instruction  E  to  Form  S-8,  WesBanco
incorporates by reference into this  Registration  Statement the entire contents
of its earlier  Registration  Statements  on Form S-8,  File Nos.  333-06741 and
333-136179.

                                     PART II
               INFORMATION REQUIRED IN THE REGISTRATION STATEMENT

Item 3. Incorporation of Documents by Reference

     The following  documents filed by WesBanco with the Securities and Exchange
Commission (the "Commission") are incorporated herein by reference:

     1.   WesBanco's  Annual Report on Form 10-K for the year ended December 31,
          2008, filed on March 11, 2009;

     2.   WesBanco's  Current  Reports  on Form 8-K filed on January  23,  2009,
          January 26, 2009, March 30, 2009 and April 15, 2009; and

     3.   The  description  of WesBanco's  common stock  contained in WesBanco's
          Registration  Statement on Form 8-A filed pursuant to Section 12(g) of
          the  Securities  Exchange Act of 1934, as amended,  on May 2, 1977, as
          amended on June 10, 1977.

     All other  documents  filed by  WesBanco  with the  Commission  pursuant to
Sections 13(a),  13(c), 14 and 15(d) of the Securities  Exchange Act of 1934, as
amended,  subsequent to the date of this registration statement and prior to the
filing  of a  post-effective  amendment  which  indicates  that  all  securities
registered  hereby  have  been sold or which  deregisters  all  securities  then
remaining  unsold,  shall be  deemed to be  incorporated  by  reference  in this
registration  statement  and to be part  hereof  from the date of filing of such
documents.  Any statement  contained in a document  incorporated or deemed to be
incorporated  by reference  herein shall be deemed to be modified or  superseded
for  purposes  of this  registration  statement  to the extent  that a statement
contained  herein or in any other  subsequently  filed  document  which  also is
incorporated  or deemed to be  incorporated  by  reference  herein  modifies  or
supersedes  such statement.  Any such statement so modified or superseded  shall
not be deemed, except as so modified or superseded, to constitute a part of this
registration  statement.  Pursuant  to General  Instruction  B of Form 8-K,  any
information  submitted  under Item 2.02,  Results of  Operations  and  Financial
Condition, or Item 7.01, Regulation FD Disclosure,  of Form 8-K is not deemed to
be "filed" for the  purpose of Section 18 of the  Exchange  Act,  and we are not
subject to the  liabilities of Section 18 with respect to information  submitted
under Item 2.02 or Item 7.01 of Form 8-K. We are not  incorporating by reference
any  information  submitted  under  Item  2.02 or Item 7.01 of Form 8-K into any
filing under the  Securities  Act or the Exchange Act or into this  Registration
Statement.

Item 5. Interests of Named Experts and Counsel

     James C.  Gardill,  Esq.,  a member in the law firm of  Phillips,  Gardill,
Kaiser &  Altmeyer,  PLLC whose legal  opinion  with  respect to the  securities
registered  hereunder  is filed as Exhibit  5.1 hereto,  is the  Chairman of the
Board of Directors of WesBanco.

Item 8.  Exhibits.

     WesBanco  has  submitted  the Plan to the  Internal  Revenue  Service  (the
"IRS").  WesBanco hereby undertakes to submit any amendments  thereto to the IRS
in a timely manner and has made or will make all changes  required by the IRS in
order to qualify the Plan under Section 401 of the Internal Revenue Code.


                                      II-2
<PAGE>


     The following  exhibits are filed herewith or  incorporated by reference as
part of this Registration Statement:

<TABLE>
   <S>                       <C>
Exhibit No.               Description


  4.1     Restated Articles of Incorporation of WesBanco,  Inc. (incorporated by
          reference to a Registration  Statement on Form S-4 under  Registration
          No. 333-03905 filed by the Registrant with the Securities and Exchange
          Commission on May 16, 1996).

  4.2     Articles of Amendment to the Articles of  Incorporation  of WesBanco,
          Inc.  (incorporated  by reference to Form 10-Q filed by the Registrant
          with the Securities and Exchange Commission on May 15, 1998).

  4.3     Bylaws of WesBanco,  Inc. (as amended on April 26, 2007) (incorporated
          by reference to the Current Report on Form 8-K filed by the Registrant
          with the Securities and Exchange Commission on April 27, 2007).

  4.4     Certificate  of  Designations  for  Fixed  Rate  Cumulative  Perpetual
          Preferred Stock, Series A of WesBanco, Inc. (incorporated by reference
          to the Current  Report on Form 8-K filed by  WesBanco,  Inc.  with the
          Securities and Exchange Commission on December 8, 2008).

  4.5     Amended and Restated WesBanco, Inc. KSOP (incorporated by reference to
          Exhibit 10.16 to the  Registrant's  Form 10-K filed by the  Registrant
          with the Securities and Exchange Commission on March 10, 2006).

  4.6     Amendment No. 1 to WesBanco, Inc. KSOP (filed herewith).

  4.7     Second Amendment to the WesBanco, Inc. KSOP (filed herewith).

  4.8     Third Amendment to the WesBanco, Inc. KSOP (filed herewith).

  5.1     Opinion of Phillips,  Gardill, Kaiser & Altmeyer,  PLLC, regarding the
          legality of the shares being registered hereunder (filed herewith).

 23.1     Consent of Ernst & Young LLP (filed herewith).

 23.2     Consent of Phillips, Gardill, Kaiser & Altmeyer, PLLC (included in the
          Opinion filed as Exhibit 5.1).

 24.1     Power  of  Attorney  (set  forth  on  the   signature   page  of  this
          Registration Statement).
</TABLE>


                                      II-3
<PAGE>


                                   SIGNATURES

     Pursuant to the requirements of the Securities Act of 1933, as amended, the
registrant certifies that it has reasonable grounds to believe that it meets all
of the requirements for filing on Form S-8 and has duly caused this Registration
Statement  to be  signed  on its  behalf  by  the  undersigned,  thereunto  duly
authorized, in the City of Wheeling, State of West Virginia, on this 24th day of
April, 2009.

                                     WESBANCO, INC.

                                     By: /s/ Paul M. Limbert
                                        ----------------------------------------
                                        Paul M. Limbert
                                        President and Chief Executive Officer

     KNOW ALL MEN BY THESE PRESENTS,  that each person whose  signature  appears
below  constitutes and appoints Paul M. Limbert and Robert H. Young, and each of
them, his or her true and lawful attorneys-in-fact and agent, with full power of
substitution  and  resubstitution,  for him or her and in his or her name, place
and stead,  in any and all  capacities,  to sign any and all  amendments to this
Registration  Statement,  and to file the same, with all exhibits  thereto,  and
other  documentation in connection  therewith,  with the Securities and Exchange
Commission,  granting unto said attorneys-in-fact and agents with full power and
authority to do and perform each and every act and thing requisite and necessary
to be done in or about the premises,  as fully to all intents and purposes as he
or she might or could do in person,  hereby  ratifying and  confirming  all that
said  attorneys-in-fact  and agents,  or their  substitute  or  substitutes  may
lawfully do or cause to be done by virtue hereof.

     Pursuant to the  requirements  of the  Securities  Act of 1933, as amended,
this  Registration  Statement  has been signed by the  following  persons in the
capacities and on the dates indicated.

<TABLE>
            <S>                            <C>                            <C>

          Signature                       Title                          Date
------------------------------    ----------------------         ----------------------

                                  President, Chief Executive      April 24, 2009
/s/ Paul M. Limbert               Officer and Director
--------------------              (Principal Executive
Paul M. Limbert                   Officer)

                                   Executive Vice President       April 24, 2009
/s/ Robert H. Young                and Chief Financial Officer
--------------------               (Principal Financial and
Robert H. Young                    Accounting Officer)

                                   Director
----------------------
James E. Altmeyer

                                   Director
----------------
Ray A. Byrd

/s/ R. Peterson Chalfant           Director                       April 24, 2009
-------------------------
R. Peterson Chalfant

                                      II-4
<PAGE>


          Signature                       Title                          Date
------------------------------    ----------------------         ----------------------

/s/ Christopher V. Criss           Director                       April 24, 2009
-------------------------
Christopher V. Criss

                                   Director
-------------------------------
Robert M. D'Alessandri, MD

/s/ Abigail M. Feinknopf           Director                       April 24, 2009
-------------------------
Abigail M. Feinknopf

/s/ John W. Fisher, II             Director                       April 24, 2009
-----------------------
John W. Fisher, II

/s/ Ernest S. Fragale              Director                       April 24, 2009
----------------------
Ernest S. Fragale

/s/ James C. Gardill               Director                       April 24, 2009
---------------------
James C. Gardill

/s/ John D. Kidd                   Director                       April 24, 2009
-----------------
John D. Kidd

/s/ Vaughn L. Kiger                Director                       April 24, 2009
--------------------
Vaughn L. Kiger

/s/ Robert E. Kirkbride            Director                       April 24, 2009
------------------------
Robert E. Kirkbride

/s/ D. Bruce Knox                  Director                       April 24, 2009
------------------
D. Bruce Knox

/s/ Jay T. McCamic                 Director                       April 24, 2009
-------------------
Jay T. McCamic

/s/ F. Eric Nelson, Jr.            Director                       April 24, 2009
------------------------
F. Eric Nelson, Jr.


                                      II-5
<PAGE>

          Signature                       Title                          Date
------------------------------    ----------------------         ----------------------

/s/ Henry L. Schulhoff             Director                       April 24, 2009
-----------------------
Henry L. Schulhoff

/s/ Joan C. Stamp                  Director                       April 24, 2009
------------------
Joan C. Stamp

/s/ Neil S. Strawser               Director                       April 24, 2009
---------------------
Neil S. Strawser

/s/ Reed J. Tanner                 Director                       April 24, 2009
-------------------
Reed J. Tanner

/s/ Donald P. Wood                 Director                       April 24, 2009
-------------------
Donald P. Wood
</TABLE>


                                      II-6
<PAGE>



                                  EXHIBIT INDEX

<TABLE>
   <S>                           <C>
Exhibit No.                 Description

   4.1         Restated   Articles   of   Incorporation   of   WesBanco,    Inc.
               (Incorporated  by reference to a  Registration  Statement on Form
               S-4 under Registration No. 333-03905 filed by the Registrant with
               the Securities and Exchange Commission on May 16, 1996).

   4.2         Articles  of  Amendment  to  the  Articles  of  Incorporation  of
               WesBanco, Inc.  (Incorporated by reference to Form 10-Q filed by
               the Registrant with the Securities and Exchange Commission on May
               15, 1998).

   4.3         Bylaws  of  WesBanco,   Inc.  (as  amended  on  April  26,  2007)
               (incorporated  by  reference  to the  Current  Report on Form 8-K
               filed  by  the  Registrant   with  the  Securities  and  Exchange
               Commission on April 27, 2007).

   4.4         Certificate of Designations  for Fixed Rate Cumulative  Perpetual
               Preferred  Stock,  Series A of WesBanco,  Inc.  (incorporated  by
               reference  to the Current  Report on Form 8-K filed by  WesBanco,
               Inc. with the Securities  and Exchange  Commission on December 8,
               2008).

   4.5         Amended  and  Restated  WesBanco,   Inc.  KSOP  (Incorporated  by
               reference to Exhibit 10.16 to the Registrant's Form 10-K filed by
               the Registrant  with the  Securities  and Exchange  Commission on
               March 10, 2006).

   4.6         Amendment No. 1 to WesBanco, Inc. KSOP (filed herewith).

   4.7         Second Amendment to the WesBanco, Inc. KSOP (filed herewith).

   4.8         Third Amendment to the WesBanco, Inc. KSOP (filed herewith).

   5.1         Opinion of Phillips,  Gardill, Kaiser & Altmeyer, PLLC, regarding
               the  legality of the shares  being  registered  hereunder  (filed
               herewith).

  23.1         Consent of Ernst & Young LLP (filed herewith).

  23.2         Consent of Phillips,  Gardill,  Kaiser & Altmeyer, PLLC (included
               in the Opinion filed as Exhibit 5.1).

  24.1         Power  of  Attorney  (set  forth  on the  signature  page of this
               Registration Statement).
</TABLE>


                                      II-7
[{"type": "S-8", "sequence": "1", "filename": "forms8.txt", "description": "FORM S-8", "secsgml_size_bytes": 19378}]
{"company-data": {"conformed-name": "WESBANCO INC", "cik": "0000203596", "assigned-sic": "6021", "irs-number": "550571723", "state-of-incorporation": "WV", "fiscal-year-end": "1231"}, "filing-values": {"form-type": "S-8", "act": "33", "file-number": "333-158749", "film-number": "09769772"}, "business-address": {"street1": "1 BANK PLAZA", "city": "WHEELING", "state": "WV", "zip": "26003", "phone": "3042349000"}, "mail-address": {"street1": "ONE BANK PLZ", "city": "WHEELING", "state": "WV", "zip": "26003"}}
As filed with the Securities and Exchange Commission on April 24, 2009
                                                          Registration No. 333-

--------------------------------------------------------------------------------
                       SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549

                                    FORM S-8
                             REGISTRATION STATEMENT
                                      UNDER
                           THE SECURITIES ACT OF 1933

                                 WESBANCO, INC.
             (Exact name of registrant as specified in its charter)

      West Virginia                                     55-0571723
(State or other jurisdiction of                       (IRS Employer
 incorporation or organization)                      Identification No.)
                                 One Bank Plaza
                          Wheeling, West Virginia 26003
                                 (304) 234-9000
       (Address, including zip code, and telephone number, including area
               code, of Registrant's principal executive offices)

                               WESBANCO, INC. KSOP
                            (Full title of the Plan)

                                 Paul M. Limbert
                      President and Chief Executive Officer
                                 WesBanco, Inc.
                                 One Bank Plaza
                          Wheeling, West Virginia 26003
                                 (304) 234-9000
 (Name, address, including zip code, and telephone number, including area code,
                              of agent for service)

                                                 Copies to:
James C. Gardill, Esq.                           Paul C. Cancilla, Esq.
Phillips, Gardill, Kaiser & Altmeyer, PLLC       K&L Gates LLP
61 Fourteenth Street                             Henry W. Oliver Building
Wheeling, WV 26003                               535 Smithfield Street
(304) 232-6810                                   Pittsburgh, PA 15222
                                                 (412) 355-6500

Indicate by check mark whether the registrant is a large  accelerated  filer, an
accelerated filer, a non-accelerated  filer or a smaller reporting company.  See
the definitions of "large accelerated  filer,"  "accelerated filer" and "smaller
reporting company" in Rule 12b-2 of the Exchange Act. (Check one):
Large accelerated filer  / /   Accelerated filer |X|  Non-accelerated filer  / /   Smaller reporting
                                                     (Do not check if a smaller     company / /
                                                         reporting company)
CALCULATION OF REGISTRATION FEE
-------------------------------- ------------- --------------- --------------- --------------------------
                                                 Proposed        Proposed
           Title of                               maximum         maximum       Amount of registration
          securities              Amount to      offering        aggregate                fee
       to be registered               be         price per       offering
                                 registered(1)    share(2)        price(2)
-------------------------------- ------------- --------------- --------------- --------------------------

Common Stock, $2.0833 par          750,000        $22.47         $16,852,500           $940.37
value per share

-------------------------------- ------------- --------------- --------------- --------------------------
(1) This amount  represents a 750,000 share  increase in the number of shares of
the  Registrant's  common stock,  $2.0833 par value per share  ("Common  Stock")
authorized for issuance under the WesBanco, Inc. KSOP. In addition to the shares
set forth in the table,  pursuant to Rule  416(a)  under the  Securities  Act of
1933, as amended ("Securities Act"), this registration  statement also covers an
indeterminable number of shares of Common Stock that may be issuable as a result
of stock splits, stock dividends and anti-dilution provisions.

(2)  Estimated  solely  for the  purpose of  calculating  the  registration  fee
pursuant to Rule 457(h) and Rule 457(c)  under the  Securities  Act.  The fee is
calculated  on the  basis of the  average  of the high  and low  prices  for the
Registrant's  Common Stock  reported on the NASDAQ Global Select Market on April
21, 2009.
TABLE OF CONTENTS

PART II
     Item 3.  Incorporation of Documents by Reference
     Item 5.  Interests of Named Experts and Counsel
     Item 8.  Exhibits
SIGNATURES
INDEX TO EXHIBITS
EX-5.1:  OPINION OF PHILLIPS, GARDILL, KAISER & ALTMEYER, PLLC
EX-23.1:  CONSENT OF INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRM

                                      II-1
EXPLANATORY NOTE

     This  Registration  Statement on Form S-8 is being filed by WesBanco,  Inc.
("WesBanco")  to register an  additional  750,000  shares of  WesBanco's  common
stock,  par value of $2.0833 per share,  issuable under the WesBanco,  Inc. KSOP
(the  "Plan").   Pursuant  to  General  Instruction  E  to  Form  S-8,  WesBanco
incorporates by reference into this  Registration  Statement the entire contents
of its earlier  Registration  Statements  on Form S-8,  File Nos.  333-06741 and
333-136179.

                                     PART II
               INFORMATION REQUIRED IN THE REGISTRATION STATEMENT

Item 3. Incorporation of Documents by Reference

     The following  documents filed by WesBanco with the Securities and Exchange
Commission (the "Commission") are incorporated herein by reference:

     1.   WesBanco's  Annual Report on Form 10-K for the year ended December 31,
          2008, filed on March 11, 2009;

     2.   WesBanco's  Current  Reports  on Form 8-K filed on January  23,  2009,
          January 26, 2009, March 30, 2009 and April 15, 2009; and

     3.   The  description  of WesBanco's  common stock  contained in WesBanco's
          Registration  Statement on Form 8-A filed pursuant to Section 12(g) of
          the  Securities  Exchange Act of 1934, as amended,  on May 2, 1977, as
          amended on June 10, 1977.

     All other  documents  filed by  WesBanco  with the  Commission  pursuant to
Sections 13(a),  13(c), 14 and 15(d) of the Securities  Exchange Act of 1934, as
amended,  subsequent to the date of this registration statement and prior to the
filing  of a  post-effective  amendment  which  indicates  that  all  securities
registered  hereby  have  been sold or which  deregisters  all  securities  then
remaining  unsold,  shall be  deemed to be  incorporated  by  reference  in this
registration  statement  and to be part  hereof  from the date of filing of such
documents.  Any statement  contained in a document  incorporated or deemed to be
incorporated  by reference  herein shall be deemed to be modified or  superseded
for  purposes  of this  registration  statement  to the extent  that a statement
contained  herein or in any other  subsequently  filed  document  which  also is
incorporated  or deemed to be  incorporated  by  reference  herein  modifies  or
supersedes  such statement.  Any such statement so modified or superseded  shall
not be deemed, except as so modified or superseded, to constitute a part of this
registration  statement.  Pursuant  to General  Instruction  B of Form 8-K,  any
information  submitted  under Item 2.02,  Results of  Operations  and  Financial
Condition, or Item 7.01, Regulation FD Disclosure,  of Form 8-K is not deemed to
be "filed" for the  purpose of Section 18 of the  Exchange  Act,  and we are not
subject to the  liabilities of Section 18 with respect to information  submitted
under Item 2.02 or Item 7.01 of Form 8-K. We are not  incorporating by reference
any  information  submitted  under  Item  2.02 or Item 7.01 of Form 8-K into any
filing under the  Securities  Act or the Exchange Act or into this  Registration
Statement.

Item 5. Interests of Named Experts and Counsel

     James C.  Gardill,  Esq.,  a member in the law firm of  Phillips,  Gardill,
Kaiser &  Altmeyer,  PLLC whose legal  opinion  with  respect to the  securities
registered  hereunder  is filed as Exhibit  5.1 hereto,  is the  Chairman of the
Board of Directors of WesBanco.

Item 8.  Exhibits.

     WesBanco  has  submitted  the Plan to the  Internal  Revenue  Service  (the
"IRS").  WesBanco hereby undertakes to submit any amendments  thereto to the IRS
in a timely manner and has made or will make all changes  required by the IRS in
order to qualify the Plan under Section 401 of the Internal Revenue Code.

                                      II-2
The following  exhibits are filed herewith or  incorporated by reference as
part of this Registration Statement:
Exhibit No.               Description

  4.1     Restated Articles of Incorporation of WesBanco,  Inc. (incorporated by
          reference to a Registration  Statement on Form S-4 under  Registration
          No. 333-03905 filed by the Registrant with the Securities and Exchange
          Commission on May 16, 1996).

  4.2     Articles of Amendment to the Articles of  Incorporation  of WesBanco,
          Inc.  (incorporated  by reference to Form 10-Q filed by the Registrant
          with the Securities and Exchange Commission on May 15, 1998).

  4.3     Bylaws of WesBanco,  Inc. (as amended on April 26, 2007) (incorporated
          by reference to the Current Report on Form 8-K filed by the Registrant
          with the Securities and Exchange Commission on April 27, 2007).

  4.4     Certificate  of  Designations  for  Fixed  Rate  Cumulative  Perpetual
          Preferred Stock, Series A of WesBanco, Inc. (incorporated by reference
          to the Current  Report on Form 8-K filed by  WesBanco,  Inc.  with the
          Securities and Exchange Commission on December 8, 2008).

  4.5     Amended and Restated WesBanco, Inc. KSOP (incorporated by reference to
          Exhibit 10.16 to the  Registrant's  Form 10-K filed by the  Registrant
          with the Securities and Exchange Commission on March 10, 2006).

  4.6     Amendment No. 1 to WesBanco, Inc. KSOP (filed herewith).

  4.7     Second Amendment to the WesBanco, Inc. KSOP (filed herewith).

  4.8     Third Amendment to the WesBanco, Inc. KSOP (filed herewith).

  5.1     Opinion of Phillips,  Gardill, Kaiser & Altmeyer,  PLLC, regarding the
          legality of the shares being registered hereunder (filed herewith).

 23.1     Consent of Ernst & Young LLP (filed herewith).

 23.2     Consent of Phillips, Gardill, Kaiser & Altmeyer, PLLC (included in the
          Opinion filed as Exhibit 5.1).

 24.1     Power  of  Attorney  (set  forth  on  the   signature   page  of  this
          Registration Statement).
II-3
SIGNATURES

     Pursuant to the requirements of the Securities Act of 1933, as amended, the
registrant certifies that it has reasonable grounds to believe that it meets all
of the requirements for filing on Form S-8 and has duly caused this Registration
Statement  to be  signed  on its  behalf  by  the  undersigned,  thereunto  duly
authorized, in the City of Wheeling, State of West Virginia, on this 24th day of
April, 2009.

                                     WESBANCO, INC.

                                     By: /s/ Paul M. Limbert
                                        ----------------------------------------
                                        Paul M. Limbert
                                        President and Chief Executive Officer

     KNOW ALL MEN BY THESE PRESENTS,  that each person whose  signature  appears
below  constitutes and appoints Paul M. Limbert and Robert H. Young, and each of
them, his or her true and lawful attorneys-in-fact and agent, with full power of
substitution  and  resubstitution,  for him or her and in his or her name, place
and stead,  in any and all  capacities,  to sign any and all  amendments to this
Registration  Statement,  and to file the same, with all exhibits  thereto,  and
other  documentation in connection  therewith,  with the Securities and Exchange
Commission,  granting unto said attorneys-in-fact and agents with full power and
authority to do and perform each and every act and thing requisite and necessary
to be done in or about the premises,  as fully to all intents and purposes as he
or she might or could do in person,  hereby  ratifying and  confirming  all that
said  attorneys-in-fact  and agents,  or their  substitute  or  substitutes  may
lawfully do or cause to be done by virtue hereof.

     Pursuant to the  requirements  of the  Securities  Act of 1933, as amended,
this  Registration  Statement  has been signed by the  following  persons in the
capacities and on the dates indicated.
Signature                       Title                          Date
------------------------------    ----------------------         ----------------------

                                  President, Chief Executive      April 24, 2009
/s/ Paul M. Limbert               Officer and Director
--------------------              (Principal Executive
Paul M. Limbert                   Officer)

                                   Executive Vice President       April 24, 2009
/s/ Robert H. Young                and Chief Financial Officer
--------------------               (Principal Financial and
Robert H. Young                    Accounting Officer)

                                   Director
----------------------
James E. Altmeyer

                                   Director
----------------
Ray A. Byrd

/s/ R. Peterson Chalfant           Director                       April 24, 2009
-------------------------
R. Peterson Chalfant

                                      II-4
Signature                       Title                          Date
------------------------------    ----------------------         ----------------------

/s/ Christopher V. Criss           Director                       April 24, 2009
-------------------------
Christopher V. Criss

                                   Director
-------------------------------
Robert M. D'Alessandri, MD

/s/ Abigail M. Feinknopf           Director                       April 24, 2009
-------------------------
Abigail M. Feinknopf

/s/ John W. Fisher, II             Director                       April 24, 2009
-----------------------
John W. Fisher, II

/s/ Ernest S. Fragale              Director                       April 24, 2009
----------------------
Ernest S. Fragale

/s/ James C. Gardill               Director                       April 24, 2009
---------------------
James C. Gardill

/s/ John D. Kidd                   Director                       April 24, 2009
-----------------
John D. Kidd

/s/ Vaughn L. Kiger                Director                       April 24, 2009
--------------------
Vaughn L. Kiger

/s/ Robert E. Kirkbride            Director                       April 24, 2009
------------------------
Robert E. Kirkbride

/s/ D. Bruce Knox                  Director                       April 24, 2009
------------------
D. Bruce Knox

/s/ Jay T. McCamic                 Director                       April 24, 2009
-------------------
Jay T. McCamic

/s/ F. Eric Nelson, Jr.            Director                       April 24, 2009
------------------------
F. Eric Nelson, Jr.

                                      II-5
Signature                       Title                          Date
------------------------------    ----------------------         ----------------------

/s/ Henry L. Schulhoff             Director                       April 24, 2009
-----------------------
Henry L. Schulhoff

/s/ Joan C. Stamp                  Director                       April 24, 2009
------------------
Joan C. Stamp

/s/ Neil S. Strawser               Director                       April 24, 2009
---------------------
Neil S. Strawser

/s/ Reed J. Tanner                 Director                       April 24, 2009
-------------------
Reed J. Tanner

/s/ Donald P. Wood                 Director                       April 24, 2009
-------------------
Donald P. Wood
II-6
EXHIBIT INDEX
Exhibit No.                 Description

   4.1         Restated   Articles   of   Incorporation   of   WesBanco,    Inc.
               (Incorporated  by reference to a  Registration  Statement on Form
               S-4 under Registration No. 333-03905 filed by the Registrant with
               the Securities and Exchange Commission on May 16, 1996).

   4.2         Articles  of  Amendment  to  the  Articles  of  Incorporation  of
               WesBanco, Inc.  (Incorporated by reference to Form 10-Q filed by
               the Registrant with the Securities and Exchange Commission on May
               15, 1998).

   4.3         Bylaws  of  WesBanco,   Inc.  (as  amended  on  April  26,  2007)
               (incorporated  by  reference  to the  Current  Report on Form 8-K
               filed  by  the  Registrant   with  the  Securities  and  Exchange
               Commission on April 27, 2007).

   4.4         Certificate of Designations  for Fixed Rate Cumulative  Perpetual
               Preferred  Stock,  Series A of WesBanco,  Inc.  (incorporated  by
               reference  to the Current  Report on Form 8-K filed by  WesBanco,
               Inc. with the Securities  and Exchange  Commission on December 8,
               2008).

   4.5         Amended  and  Restated  WesBanco,   Inc.  KSOP  (Incorporated  by
               reference to Exhibit 10.16 to the Registrant's Form 10-K filed by
               the Registrant  with the  Securities  and Exchange  Commission on
               March 10, 2006).

   4.6         Amendment No. 1 to WesBanco, Inc. KSOP (filed herewith).

   4.7         Second Amendment to the WesBanco, Inc. KSOP (filed herewith).

   4.8         Third Amendment to the WesBanco, Inc. KSOP (filed herewith).

   5.1         Opinion of Phillips,  Gardill, Kaiser & Altmeyer, PLLC, regarding
               the  legality of the shares  being  registered  hereunder  (filed
               herewith).

  23.1         Consent of Ernst & Young LLP (filed herewith).

  23.2         Consent of Phillips,  Gardill,  Kaiser & Altmeyer, PLLC (included
               in the Opinion filed as Exhibit 5.1).

  24.1         Power  of  Attorney  (set  forth  on the  signature  page of this
               Registration Statement).
II-7