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<P STYLE="font: bold 10pt Times New Roman,serif; margin: 0; text-align: center">As filed with the United States Securities and
Exchange Commission on February 28, 2013</P>

<P STYLE="font: 10pt Times New Roman,serif; margin: 0; text-align: right"><B>Registration No. 333-________</B></P>

<HR SIZE="1" NOSHADE ALIGN="LEFT" STYLE="width: 100%; color: black">

<P STYLE="font: bold 10pt Times New Roman,serif; margin: 0; text-align: center">UNITED STATES<BR>
SECURITIES AND EXCHANGE COMMISSION<BR>
Washington, D.C. 20549</P>

<P STYLE="font: 12pt Times New Roman,serif; margin: 0; text-align: center">_________________</P>

<P STYLE="font: 12pt Times New Roman,serif; margin: 0; text-align: center">FORM S-8<BR>
REGISTRATION STATEMENT</P>

<P STYLE="font: 12pt Times New Roman,serif; margin: 0; text-align: center">Under<BR>
THE SECURITIES ACT OF 1933</P>

<P STYLE="font: 12pt Times New Roman,serif; margin: 0 0 12pt; text-align: center">___________________</P>

<P STYLE="font: 18pt Times New Roman,serif; margin: 0; text-align: center"><B>MAKO Surgical Corp.</B></P>

<P STYLE="font: 8pt Times New Roman,serif; margin: 0; text-align: center">(Exact name of registrant as specified in its charter)</P>

<P STYLE="font: 8pt Times New Roman,serif; margin: 0; text-align: center">&nbsp;</P>

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    <TD STYLE="width: 50%; font: 10pt Times New Roman,serif; text-align: center"><FONT STYLE="font-size: 10pt">Delaware</FONT></TD>
    <TD STYLE="width: 50%; font: 10pt Times New Roman,serif; text-align: center"><FONT STYLE="font-size: 10pt">20-1901148</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="font: 8pt Times New Roman,serif; text-align: center"><FONT STYLE="font-size: 8pt">(State or Other Jurisdiction of</FONT><BR>
<FONT STYLE="font-size: 8pt">Incorporation or Organization)</FONT></TD>
    <TD STYLE="font: 8pt Times New Roman,serif; text-align: center"><FONT STYLE="font-size: 8pt">(I.R.S. Employer</FONT><BR>
<FONT STYLE="font-size: 8pt">Identification No.)</FONT></TD></TR>
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<P STYLE="font: 10pt Times New Roman,serif; margin: 0; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman,serif; margin: 0; text-align: center">2555 Davie Road<BR>
Fort Lauderdale, Florida 33317</P>

<P STYLE="font: 8pt Times New Roman,serif; margin: 0; text-align: center">(Address, Including Zip Code, of Principal Executive
Offices)</P>

<P STYLE="font: 12pt Times New Roman,serif; margin: 0 0 12pt; text-align: center">___________________</P>

<P STYLE="font: 14pt Times New Roman,serif; margin: 0; text-align: center"><B>MAKO Surgical Corp. 2008 Omnibus Incentive Plan </B></P>

<P STYLE="font: 8pt Times New Roman,serif; margin: 0; text-align: center">(Full Title of the Plan)</P>

<P STYLE="font: 10pt Times New Roman,serif; margin: 0 0 12pt; text-align: center">___________________</P>

<P STYLE="font: 10pt Times New Roman,serif; margin: 0; text-align: center">Maurice R. Ferr&eacute;, M.D.<BR>
President and Chief Executive Officer<BR>
MAKO Surgical Corp.<BR>
2555 Davie Road, Fort Lauderdale, Florida 33317<BR>
(954) 927-2044<BR>
(Name, Address and Telephone Number, Including Area Code, of Agent for Service)</P>

<P STYLE="font: 10pt Times New Roman,serif; margin: 0; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman,serif; margin: 0; text-align: center">COPY TO:<BR>
Jay O. Rothman, Esq.<BR>
Foley &amp; Lardner LLP<BR>
777 East Wisconsin Avenue<BR>
Milwaukee, Wisconsin 53202<BR>
(414) 271-2400</P>

<P STYLE="font: 10pt Times New Roman,serif; margin: 0; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman,serif; margin: 0 0 3pt; text-align: justify; text-indent: 35.1pt"><FONT STYLE="letter-spacing: -0.1pt">Indicate
by check mark whether the registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer or a smaller reporting
company. See the definition of &ldquo;large accelerated filer,&rdquo; &ldquo;accelerated filer&rdquo; and &ldquo;smaller reporting
company&rdquo; in Rule 12b-2 of the Exchange Act. (Check one):</FONT></P>

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    <TD STYLE="width: 25%; padding-bottom: 3pt; font-family: Times New Roman,serif; text-align: center"><FONT STYLE="font-size: 10pt; letter-spacing: -0.1pt">Large accelerated filer&nbsp;&nbsp;<FONT STYLE="font-family: MS Mincho">&#9746;</FONT></FONT></TD>
    <TD STYLE="width: 25%; padding-bottom: 3pt; font-family: Times New Roman,serif; text-align: center"><FONT STYLE="font-size: 10pt; letter-spacing: -0.1pt">Accelerated filer&nbsp;&nbsp;<FONT STYLE="font-family: MS Mincho">&#9744;</FONT></FONT></TD>
    <TD STYLE="width: 25%; padding-bottom: 3pt; font-family: Times New Roman,serif; text-align: center"><FONT STYLE="font-size: 10pt; letter-spacing: -0.1pt">Non-accelerated filer&nbsp;&nbsp;<FONT STYLE="font-family: MS Mincho">&#9744;</FONT></FONT></TD>
    <TD STYLE="width: 25%; padding-bottom: 3pt; font-family: Times New Roman,serif; text-align: center"><FONT STYLE="font-size: 10pt; letter-spacing: -0.1pt">Non Smaller reporting company&nbsp;&nbsp;<FONT STYLE="font-family: MS Mincho">&#9744;</FONT></FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-bottom: 3pt; font-family: Times New Roman,serif; text-align: center">&nbsp;</TD>
    <TD STYLE="padding-bottom: 3pt; font-family: Times New Roman,serif; text-align: center">&nbsp;</TD>
    <TD STYLE="padding-bottom: 3pt; font-family: Times New Roman,serif; text-align: center"><FONT STYLE="font-size: 10pt; letter-spacing: -0.1pt">(Do not check if smaller reporting company)</FONT></TD>
    <TD STYLE="padding-bottom: 3pt; font-family: Times New Roman,serif; text-align: center">&nbsp;</TD></TR>
</TABLE>
<P STYLE="font: 10pt Times New Roman,serif; margin: 0 0 6pt; text-align: center">___________________</P>

<P STYLE="font: 12pt Times New Roman,serif; margin: 0 19.45pt 6pt 0; text-align: center"><B>&nbsp;</B></P>

<P STYLE="font: 12pt Times New Roman,serif; margin: 0 19.45pt 6pt 0; text-align: center"></P>

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<P STYLE="font: 12pt Times New Roman,serif; margin: 0 19.45pt 6pt 0; text-align: center"><B>&nbsp;</B></P>

<P STYLE="font: 12pt Times New Roman,serif; margin: 0 19.45pt 6pt 0; text-align: center"><B>CALCULATION OF REGISTRATION FEE</B></P>

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    <TD STYLE="width: 20%; border-top: windowtext 1pt solid; border-bottom: windowtext 1pt solid; font: bold 8pt Times New Roman,serif; padding-top: 1.5pt; padding-right: 19.45pt; padding-bottom: 1.5pt"><FONT STYLE="font-size: 8pt"><B>Title of Securities</B></FONT><BR>
<FONT STYLE="font-size: 8pt"><B>To Be Registered</B></FONT></TD>
    <TD STYLE="width: 20%; border-top: windowtext 1pt solid; border-bottom: windowtext 1pt solid; font: bold 12pt Times New Roman,serif; padding-top: 1.5pt; padding-right: 19.45pt; padding-bottom: 1.5pt"><FONT STYLE="font-size: 8pt"><B>Amount</B></FONT><BR>
<FONT STYLE="font-size: 8pt"><B>To Be</B></FONT><BR>
<FONT STYLE="font-size: 8pt"><B>Registered</B></FONT><B><FONT STYLE="font-size: 10pt"><SUP>(1)</SUP></FONT></B></TD>
    <TD STYLE="width: 20%; border-top: windowtext 1pt solid; border-bottom: windowtext 1pt solid; font: bold 12pt Times New Roman,serif; padding-top: 1.5pt; padding-right: 19.45pt; padding-bottom: 1.5pt"><FONT STYLE="font-size: 8pt"><B>Proposed</B></FONT><BR>
<FONT STYLE="font-size: 8pt"><B>Maximum</B></FONT><BR>
<FONT STYLE="font-size: 8pt"><B>Offering Price </B></FONT><BR>
<FONT STYLE="font-size: 8pt"><B>Per Unit</B></FONT><B><FONT STYLE="font-size: 10pt"><SUP>(2)</SUP></FONT></B></TD>
    <TD STYLE="width: 20%; border-top: windowtext 1pt solid; border-bottom: windowtext 1pt solid; font: bold 12pt Times New Roman,serif; padding-top: 1.5pt; padding-right: 14.85pt; padding-bottom: 1.5pt"><FONT STYLE="font-size: 8pt"><B>Proposed </B></FONT><BR>
<FONT STYLE="font-size: 8pt"><B>Maximum</B></FONT><BR>
<FONT STYLE="font-size: 8pt"><B>Aggregate Offering</B></FONT><BR>
<FONT STYLE="font-size: 8pt"><B>Price</B></FONT><B><FONT STYLE="font-size: 10pt"><SUP>(2)</SUP></FONT></B></TD>
    <TD STYLE="width: 20%; border-top: windowtext 1pt solid; border-bottom: windowtext 1pt solid; font: bold 8pt Times New Roman,serif; padding-top: 1.5pt; padding-right: 19.45pt; padding-bottom: 1.5pt"><FONT STYLE="font-size: 8pt"><B>Amount of </B></FONT><BR>
<FONT STYLE="font-size: 8pt"><B>Registration Fee</B></FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="border-bottom: windowtext 1pt solid; font: 8pt Times New Roman,serif; padding-top: 1.25pt; padding-right: 5.85pt; padding-bottom: 1.25pt"><FONT STYLE="font-size: 8pt">Common Stock, </FONT><BR>
<FONT STYLE="font-size: 8pt">par value $0.001 per share </FONT></TD>
    <TD STYLE="border-bottom: windowtext 1pt solid; font: 9pt Times New Roman,serif; padding-top: 1.25pt; padding-right: 19.45pt; padding-bottom: 1.25pt"><FONT STYLE="font-size: 9pt">1,880,930</FONT></TD>
    <TD STYLE="border-bottom: windowtext 1pt solid; font: 9pt Times New Roman,serif; padding-top: 1.25pt; padding-right: 19.45pt; padding-bottom: 1.25pt"><FONT STYLE="font-size: 9pt">$11.19</FONT></TD>
    <TD STYLE="border-bottom: windowtext 1pt solid; font: 9pt Times New Roman,serif; padding-top: 1.25pt; padding-right: 19.45pt; padding-bottom: 1.25pt"><FONT STYLE="font-size: 9pt">$21,047,606.70</FONT></TD>
    <TD STYLE="border-bottom: windowtext 1pt solid; font: 9pt Times New Roman,serif; padding-top: 1.25pt; padding-right: 19.45pt; padding-bottom: 1.25pt"><FONT STYLE="font-size: 9pt">$2,870.89</FONT></TD></TR>
</TABLE>
<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 12pt Times New Roman,serif; margin-top: 6pt; margin-bottom: 6pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.5in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-size: 10pt">(1)</FONT></TD><TD STYLE="padding-right: 0.5in"><FONT STYLE="font-size: 10pt">This Registration Statement covers, in addition to the number of
shares of Common Stock stated above, options and other rights to purchase or acquire the shares of Common Stock covered by the
prospectus of the above-named plan, and, pursuant to Rule 416 under the Securities Act of 1933, as amended (the &ldquo;Securities
Act&rdquo;), any additional shares of Common Stock which become issuable under the above-named plan by reason of any stock dividend,
stock split, recapitalization or other similar transaction effected without the receipt of consideration which results in an increase
in the number of outstanding shares of Common Stock. </FONT></TD></TR></TABLE>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 12pt Times New Roman,serif; margin-top: 0; margin-bottom: 6pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.5in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-size: 10pt">(2)</FONT></TD><TD STYLE="padding-right: 0.5in"><FONT STYLE="font-size: 10pt">Pursuant to Rule 457(h) and (c) promulgated under the Securities
Act, the maximum offering price, per share and in the aggregate, and the registration fee were calculated based upon the average
of the high and low prices of the Common Stock on February 26, 2013, as reported on the NASDAQ Global Select Market.</FONT></TD></TR></TABLE>

<P STYLE="font: 10pt Times New Roman,serif; margin: 0">Pursuant to Rule 429 under the Securities Act, the Prospectus referred to
herein also relates to the Registrant&rsquo;s Registration Statements on Form S-8 filed with the Securities and Exchange Commission
on February 28, 2008 (Registration No. 333-149445), March 12, 2009 (Registration No. 333-157889), March 10, 2010 (Registration
No. 333-165386), March 10, 2011 (Registration No. 333-172732), and March 8, 2012 (Registration No. 333-179992).</P>

<P STYLE="font: 8pt Times New Roman,serif; margin: 0 0.5in 6pt 63pt; text-indent: -27pt">&nbsp;</P>

<P STYLE="font: bold 10pt Times New Roman,serif; text-align: center; margin-right: 0; margin-left: 0">&nbsp;</P>

<P STYLE="font: bold 10pt Times New Roman,serif; text-align: center; margin-right: 0; margin-left: 0">&nbsp;</P>

<P STYLE="font: bold 10pt Times New Roman,serif; text-align: center; margin-right: 0; margin-left: 0">&nbsp;</P>

<P STYLE="font: bold 10pt Times New Roman,serif; text-align: center; margin-right: 0; margin-left: 0">&nbsp;</P>

<P STYLE="font: bold 10pt Times New Roman,serif; text-align: center; margin-right: 0; margin-left: 0">&nbsp;</P>

<P STYLE="font: bold 10pt Times New Roman,serif; text-align: center; margin-right: 0; margin-left: 0">&nbsp;</P>

<P STYLE="font: bold 10pt Times New Roman,serif; text-align: center; margin-right: 0; margin-left: 0">&nbsp;</P>

<P STYLE="font: bold 10pt Times New Roman,serif; text-align: center; margin-right: 0; margin-left: 0">&nbsp;</P>


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<P STYLE="font: bold 10pt Times New Roman,serif; text-align: center; margin-right: 0; margin-left: 0">STATEMENT PURSUANT TO GENERAL
INSTRUCTION E TO FORM S-8</P>

<P STYLE="font: 10pt Times New Roman,serif; text-indent: 22.5pt; margin-right: 0; margin-left: 0">The purpose of this Registration
Statement is to register 1,880,930 additional shares of Common Stock, $.001 par value per share (&ldquo;Common Stock&rdquo;), of
MAKO Surgical Corp. (the &ldquo;Company&rdquo;) in connection with the MAKO Surgical Corp. 2008 Omnibus Incentive Plan.</P>

<P STYLE="font: 10pt Times New Roman,serif; text-indent: 22.5pt; margin-right: 0; margin-left: 0">Pursuant to General Instruction
E of Form S-8, the contents of the Company&rsquo;s Registration Statements on Form S-8 filed with the Securities and Exchange Commission
on February 28, 2008 (Registration No. 333-149445), March 12, 2009 (Registration No. 333-157889), March 10, 2010 (Registration
No. 333-165386), March 10, 2011 (Registration No. 333-172732), and March 8, 2012 (Registration No. 333-179992), including the documents
incorporated by reference therein, are incorporated by reference into this Registration Statement, except as set forth below.</P>

<P STYLE="font: bold 10pt Times New Roman,serif; text-align: center; margin-right: 0; margin-left: 0">PART II</P>

<P STYLE="font: bold 10pt Times New Roman,serif; text-align: center; margin-right: 0; margin-left: 0">INFORMATION REQUIRED IN THE
REGISTRATION STATEMENT</P>

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<TR STYLE="vertical-align: top">
    <TD STYLE="width: 10%; font: bold 10pt Times New Roman,serif"><FONT STYLE="font-size: 10pt"><B>Item 8.</B> </FONT></TD>
    <TD STYLE="width: 90%; font: bold 10pt Times New Roman,serif; text-decoration: underline"><FONT STYLE="font-size: 10pt"><B><U>Exhibits</U>.</B> </FONT></TD></TR>
</TABLE>
<P STYLE="font: 10pt Times New Roman,serif; margin-right: 0; margin-left: 0">The exhibits filed herewith or incorporated herein
by reference are set forth in the attached Exhibit Index.</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="width: 100%; border-collapse: collapse">
<TR STYLE="vertical-align: top">
    <TD STYLE="width: 10%; font: bold 10pt Times New Roman,serif"><FONT STYLE="font-size: 10pt"><B>Item 9.</B> </FONT></TD>
    <TD STYLE="width: 90%; font: bold 10pt Times New Roman,serif; text-decoration: underline"><FONT STYLE="font-size: 10pt"><B><U>Undertakings</U>.</B> </FONT></TD></TR>
</TABLE>
<P STYLE="font: 10pt Times New Roman,serif; margin-right: 0; margin-left: 0">(a)&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;The
undersigned Registrant hereby undertakes:</P>

<P STYLE="font: 10pt Times New Roman,serif; margin-right: 0; margin-left: 0">&nbsp;&nbsp;&nbsp;&nbsp;(1)&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;To
file, during any period in which offers or sales are being made, a post-effective amendment to this Registration Statement:</P>

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<TR STYLE="vertical-align: top">
    <TD STYLE="width: 5%; font: 10pt Times New Roman,serif; text-align: right">&nbsp;</TD>
    <TD STYLE="width: 95%; font-size: 10pt"><FONT STYLE="font-size: 10pt">&nbsp;&nbsp;&nbsp;&nbsp;(i)&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; To include any prospectus required by Section 10(a)(3) of the Securities Act of 1933; </FONT></TD></TR>
</TABLE>
<P STYLE="font: 10pt Times New Roman,serif; margin: 0">&nbsp;</P>

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<TR STYLE="vertical-align: top">
    <TD STYLE="width: 5%; font: 10pt Times New Roman,serif; text-align: right">&nbsp;</TD>
    <TD STYLE="width: 95%; font-size: 10pt"><FONT STYLE="font-size: 10pt">&nbsp;&nbsp;&nbsp;&nbsp;(ii)&nbsp;&nbsp;&nbsp;&nbsp; To reflect in the prospectus any facts or events arising after the effective date of the Registration Statement (or the most recent post-effective amendment thereof) which, individually or in the aggregate, represent a fundamental change in the information set forth in the Registration Statement; </FONT></TD></TR>
</TABLE>
<P STYLE="font: 10pt Times New Roman,serif; margin: 0">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="width: 100%; border-collapse: collapse">
<TR STYLE="vertical-align: top">
    <TD STYLE="width: 5%; font: 10pt Times New Roman,serif; text-align: right">&nbsp;</TD>
    <TD STYLE="width: 95%; font-size: 10pt"><FONT STYLE="font-size: 10pt">&nbsp;&nbsp;&nbsp;&nbsp;(iii)&nbsp;&nbsp;&nbsp; To include any material information with respect to the plan of distribution not previously disclosed in the Registration Statement or any material change to such information in the Registration Statement; </FONT></TD></TR>
</TABLE>
<P STYLE="font: 10pt Times New Roman,serif; margin-right: 0; margin-left: 0"><I>provided, however,</I> that paragraphs (a)(1)(i)
and (a)(1)(ii) do not apply if the information required to be included in a post-effective amendment by those paragraphs is contained
in reports filed with or furnished to the Securities and Exchange Commission by the Registrant pursuant to Section&nbsp;13 or Section&nbsp;15(d)
of the Securities Exchange Act of 1934 that are incorporated by reference in the Registration Statement.</P>

<P STYLE="font: 10pt Times New Roman,serif; margin-right: 0; margin-left: 0">&nbsp;&nbsp;&nbsp;&nbsp;(2)&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;That,
for the purpose of determining any liability under the Securities Act of 1933, each such post-effective amendment shall be deemed
to be a new registration statement relating to the securities offered herein, and the offering of such securities at that time
shall be deemed to be the initial bona fide offering thereof.</P>

<P STYLE="font: 10pt Times New Roman,serif; margin-right: 0; margin-left: 0">&nbsp;&nbsp;&nbsp;&nbsp;(3)&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;To
remove from registration by means of a post-effective amendment any of the securities being registered which remain unsold at the
termination of the offering.</P>


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<P STYLE="font: 10pt Times New Roman,serif; margin-right: 0; margin-left: 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman,serif; margin-right: 0; margin-left: 0">&nbsp;&nbsp;&nbsp;&nbsp;(4)&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;That,
for the purpose of determining liability of the registrant under the Securities Act of 1933 to any purchaser in the initial distribution
of the securities, in a primary offering of securities of the Registrant pursuant to this Registration Statement, regardless of
the underwriting method used to sell the securities to the purchaser, if the securities are offered or sold to such purchaser by
means of any of the following communications, the Registrant will be a seller to the purchaser and will be considered to offer
or sell such securities to such purchaser:</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="width: 100%; border-collapse: collapse">
<TR STYLE="vertical-align: top">
    <TD STYLE="width: 5%; font: 10pt Times New Roman,serif; text-align: right">&nbsp;</TD>
    <TD STYLE="width: 95%; font-size: 10pt"><FONT STYLE="font-size: 10pt">&nbsp;&nbsp;&nbsp;&nbsp;(i)&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; Any preliminary prospectus or prospectus of the Registrant relating to the offering required to be filed pursuant to Rule 424 under the Securities Act of 1933; </FONT></TD></TR>
</TABLE>
<P STYLE="font: 10pt Times New Roman,serif; margin: 0">&nbsp;</P>

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<TR STYLE="vertical-align: top">
    <TD STYLE="width: 5%; font: 10pt Times New Roman,serif; text-align: right">&nbsp;</TD>
    <TD STYLE="width: 95%; font-size: 10pt"><FONT STYLE="font-size: 10pt">&nbsp;&nbsp;&nbsp;&nbsp;(ii)&nbsp;&nbsp;&nbsp;&nbsp; Any free writing prospectus relating to the offering prepared by or on behalf of the Registrant or used or referred to by the Registrant; </FONT></TD></TR>
</TABLE>
<P STYLE="font: 10pt Times New Roman,serif; margin: 0">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="width: 100%; border-collapse: collapse">
<TR STYLE="vertical-align: top">
    <TD STYLE="width: 5%; font: 10pt Times New Roman,serif; text-align: right">&nbsp;</TD>
    <TD STYLE="width: 95%; font-size: 10pt"><FONT STYLE="font-size: 10pt">&nbsp;&nbsp;&nbsp;&nbsp;(iii)&nbsp;&nbsp;&nbsp; The portion of any other free writing prospectus relating to the offering containing material information about the Registrant or its securities provided by or on behalf of the Registrant; and </FONT></TD></TR>
</TABLE>
<P STYLE="font: 10pt Times New Roman,serif; margin: 0">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="width: 100%; border-collapse: collapse">
<TR STYLE="vertical-align: top">
    <TD STYLE="width: 5%; font: 10pt Times New Roman,serif; text-align: right">&nbsp;</TD>
    <TD STYLE="width: 95%; font-size: 10pt"><FONT STYLE="font-size: 10pt">&nbsp;&nbsp;&nbsp;&nbsp;(iv)&nbsp;&nbsp;&nbsp; Any other communication that is an offer in the offering made by the Registrant to the purchaser. </FONT></TD></TR>
</TABLE>
<P STYLE="font: 10pt Times New Roman,serif; margin-right: 0; margin-left: 0">(b)&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;The
undersigned Registrant hereby undertakes that, for purposes of determining any liability under the Securities Act of 1933, each
filing of the Registrant&rsquo;s annual report pursuant to Section 13(a) or Section 15(d) of the Securities Exchange Act of 1934
that is incorporated by reference in this Registration Statement shall be deemed to be a new registration statement relating to
the securities offered herein, and the offering of such securities at that time shall be deemed to be the initial bona fide offering
thereof.</P>

<P STYLE="font: 10pt Times New Roman,serif; margin-right: 0; margin-left: 0">(c)&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Insofar
as indemnification for liabilities arising under the Securities Act of 1933 may be permitted to directors, officers and controlling
persons of the Registrant pursuant to the foregoing provisions, or otherwise, the Registrant has been advised that in the opinion
of the Commission such indemnification is against public policy as expressed in the Act and is, therefore, unenforceable. In the
event that a claim for indemnification against such liabilities (other than the payment by the Registrant of expenses incurred
or paid by a director, officer or controlling person of the Registrant in the successful defense of any action, suit or proceeding)
is asserted by such director, officer or controlling person in connection with the securities being registered, the Registrant
will, unless in the opinion of its counsel the matter has been settled by controlling precedent, submit to a court of appropriate
jurisdiction the question whether such indemnification by it is against public policy as expressed in the Act and will be governed
by the final adjudication of such issue.</P>

<P STYLE="font: 10pt Times New Roman,serif; margin-right: 0; margin-left: 0">&nbsp;</P>


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<P STYLE="font: bold 10pt Times New Roman,serif; text-align: center; margin-right: 0; margin-left: 0"><U>SIGNATURES</U></P>

<P STYLE="font: 10pt Times New Roman,serif; margin-right: 0; margin-bottom: 0; margin-left: 0">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Pursuant
to the requirements of the Securities Act of 1933, the Registrant certifies that it has reasonable grounds to believe that it meets
all of the requirements for filing on Form&nbsp;S-8 and has duly caused this Registration Statement to be signed on its behalf
by the undersigned, thereunto duly authorized, in the City of Fort Lauderdale, State of Florida, on this 28th day of February,
2013.</P>

<P STYLE="font: 10pt Times New Roman,serif; margin: 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman,serif; margin: 0">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="width: 100%; border-collapse: collapse; font-size: 10pt">
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD COLSPAN="2" STYLE="font-weight: bold"><FONT STYLE="font-size: 10pt"><B>MAKO Surgical Corp.</B></FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="width: 58%">&nbsp;</TD>
    <TD STYLE="width: 3%">&nbsp;</TD>
    <TD STYLE="width: 39%">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD><FONT STYLE="font-size: 10pt">By:</FONT></TD>
    <TD STYLE="border-bottom: windowtext 1pt solid"><FONT STYLE="font-size: 10pt">/s/ Maurice R. Ferr&eacute;, M.D.</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD><FONT STYLE="font-size: 10pt">Maurice R. Ferr&eacute;, M.D.</FONT><BR>
<FONT STYLE="font-size: 10pt"><I>President and Chief Executive Officer and</I></FONT><BR>
<FONT STYLE="font-size: 10pt"><I>Chairman of the Board</I></FONT></TD></TR>
</TABLE>
<P STYLE="font: 10pt Times New Roman,serif; margin: 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman,serif; margin: 0">Each person whose signature appears below constitutes and appoints Maurice
R. Ferr&eacute; and Fritz L. LaPorte, and each of them individually, his true and lawful attorney-in-fact and agent, with full
powers of substitution and resubstitution, for him and in his name, place and stead, in any and all capacities, to sign any and
all amendments (including post-effective amendments) to this Registration Statement, and to file the same, with all exhibits thereto,
and other documents in connection therewith, with the Securities and Exchange Commission, granting unto said attorneys-in-fact
and agents, and each of them individually, full power and authority to do and perform each and every act and thing requisite and
necessary to be done in and about the premises, as fully to all intents and purposes as he or she might or could do in person,
hereby ratifying and confirming all that said attorneys-in-fact and agents, or any of them individually, or their substitute or
substitutes, may lawfully do or cause to be done by virtue hereof.</P>

<P STYLE="font: 10pt Times New Roman,serif; margin: 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman,serif; margin: 0">Pursuant to the requirements of the Securities Act, this Registration Statement
has been signed below by the following persons in the capacities indicated below on February 28, 2013.</P>

<P STYLE="font: 10pt Times New Roman,serif; margin: 0">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="width: 100%; border-collapse: collapse; font-size: 10pt">
<TR>
    <TD STYLE="vertical-align: bottom; width: 31%; font-family: Times New Roman,serif; font-weight: bold; text-decoration: underline; text-align: center"><FONT STYLE="font-size: 10pt"><B><U>Signature</U></B></FONT></TD>
    <TD STYLE="vertical-align: top; width: 3%; font-family: Times New Roman,serif; font-weight: bold; text-align: center">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; width: 66%; font-family: Times New Roman,serif; font-weight: bold; text-decoration: underline; text-align: center"><FONT STYLE="font-size: 10pt"><B><U>Title</U></B></FONT></TD></TR>
<TR>
    <TD STYLE="vertical-align: bottom; font-family: Times New Roman,serif">&nbsp;</TD>
    <TD STYLE="vertical-align: top; font-family: Times New Roman,serif">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; font-family: Times New Roman,serif">&nbsp;</TD></TR>
<TR>
    <TD STYLE="vertical-align: bottom; border-bottom: windowtext 1pt solid; font-family: Times New Roman,serif"><FONT STYLE="font-size: 10pt">/s/ Maurice R. Ferr&eacute;, M.D.</FONT></TD>
    <TD STYLE="vertical-align: top; font-family: Times New Roman,serif">&nbsp;</TD>
    <TD STYLE="vertical-align: top; font-family: Times New Roman,serif"><FONT STYLE="font-size: 10pt">Chief Executive Officer, President and Chairman of the Board</FONT></TD></TR>
<TR>
    <TD STYLE="vertical-align: bottom; font-family: Times New Roman,serif"><FONT STYLE="font-size: 10pt">Maurice R. Ferr&eacute;, M.D.</FONT></TD>
    <TD STYLE="vertical-align: top; font-family: Times New Roman,serif">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; font-family: Times New Roman,serif"><FONT STYLE="font-size: 10pt">(Principal Executive Officer)</FONT></TD></TR>
<TR>
    <TD STYLE="vertical-align: bottom; font-family: Times New Roman,serif">&nbsp;</TD>
    <TD STYLE="vertical-align: top; font-family: Times New Roman,serif">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; font-family: Times New Roman,serif">&nbsp;</TD></TR>
<TR>
    <TD STYLE="vertical-align: bottom; border-bottom: windowtext 1pt solid; font-family: Times New Roman,serif"><FONT STYLE="font-size: 10pt">/s/ Fritz L. LaPorte</FONT></TD>
    <TD STYLE="vertical-align: top; font-family: Times New Roman,serif">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; font-family: Times New Roman,serif"><FONT STYLE="font-size: 10pt">Senior Vice President of Finance and Administration, Chief </FONT><BR>
<FONT STYLE="font-size: 10pt">Financial Officer and Treasurer (Principal&nbsp;Financial Officer and </FONT></TD></TR>
<TR>
    <TD STYLE="vertical-align: bottom; font-family: Times New Roman,serif"><FONT STYLE="font-size: 10pt">Fritz L. LaPorte</FONT></TD>
    <TD STYLE="vertical-align: top; font-family: Times New Roman,serif">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; font-family: Times New Roman,serif"><FONT STYLE="font-size: 10pt">Principal Accounting Officer)</FONT></TD></TR>
<TR>
    <TD STYLE="vertical-align: bottom; font-family: Times New Roman,serif">&nbsp;</TD>
    <TD STYLE="vertical-align: top; font-family: Times New Roman,serif">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; font-family: Times New Roman,serif">&nbsp;</TD></TR>
<TR>
    <TD STYLE="vertical-align: bottom; border-bottom: windowtext 1pt solid; font-family: Times New Roman,serif"><FONT STYLE="font-size: 10pt">/s/ S. Morry Blumenfeld, Ph.D.</FONT></TD>
    <TD STYLE="vertical-align: top; font-family: Times New Roman,serif">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; font-family: Times New Roman,serif"><FONT STYLE="font-size: 10pt">Director</FONT></TD></TR>
<TR>
    <TD STYLE="vertical-align: bottom; font-family: Times New Roman,serif"><FONT STYLE="font-size: 10pt">S. Morry Blumenfeld, Ph.D.</FONT></TD>
    <TD STYLE="vertical-align: top; font-family: Times New Roman,serif">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; font-family: Times New Roman,serif">&nbsp;</TD></TR>
<TR>
    <TD STYLE="vertical-align: bottom; font-family: Times New Roman,serif">&nbsp;</TD>
    <TD STYLE="vertical-align: top; font-family: Times New Roman,serif">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; font-family: Times New Roman,serif">&nbsp;</TD></TR>
<TR>
    <TD STYLE="vertical-align: bottom; border-bottom: windowtext 1pt solid; font-family: Times New Roman,serif"><FONT STYLE="font-size: 10pt">/s/ Christopher C. Dewey</FONT></TD>
    <TD STYLE="vertical-align: top; font-family: Times New Roman,serif">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; font-family: Times New Roman,serif"><FONT STYLE="font-size: 10pt">Director</FONT></TD></TR>
<TR>
    <TD STYLE="vertical-align: bottom; font-family: Times New Roman,serif"><FONT STYLE="font-size: 10pt">Christopher C. Dewey</FONT></TD>
    <TD STYLE="vertical-align: top; font-family: Times New Roman,serif">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; font-family: Times New Roman,serif">&nbsp;</TD></TR>
<TR>
    <TD STYLE="vertical-align: bottom; font-family: Times New Roman,serif">&nbsp;</TD>
    <TD STYLE="vertical-align: top; font-family: Times New Roman,serif">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; font-family: Times New Roman,serif">&nbsp;</TD></TR>
<TR>
    <TD STYLE="vertical-align: bottom; border-bottom: windowtext 1pt solid; font-family: Times New Roman,serif"><FONT STYLE="font-size: 10pt">/s/ Charles W. Federico</FONT></TD>
    <TD STYLE="vertical-align: top; font-family: Times New Roman,serif">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; font-family: Times New Roman,serif"><FONT STYLE="font-size: 10pt">Director</FONT></TD></TR>
<TR>
    <TD STYLE="vertical-align: bottom; font-family: Times New Roman,serif"><FONT STYLE="font-size: 10pt">Charles W. Federico</FONT></TD>
    <TD STYLE="vertical-align: top; font-family: Times New Roman,serif">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; font-family: Times New Roman,serif">&nbsp;</TD></TR>
<TR>
    <TD STYLE="vertical-align: bottom; font-family: Times New Roman,serif">&nbsp;</TD>
    <TD STYLE="vertical-align: top; font-family: Times New Roman,serif">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; font-family: Times New Roman,serif">&nbsp;</TD></TR>
<TR>
    <TD STYLE="vertical-align: bottom; border-bottom: windowtext 1pt solid; font-family: Times New Roman,serif"><FONT STYLE="font-size: 10pt">/s/ John G. Freund, M.D.</FONT></TD>
    <TD STYLE="vertical-align: top; font-family: Times New Roman,serif">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; font-family: Times New Roman,serif"><FONT STYLE="font-size: 10pt">Director</FONT></TD></TR>
<TR>
    <TD STYLE="vertical-align: bottom; font-family: Times New Roman,serif"><FONT STYLE="font-size: 10pt">John G. Freund, M.D.</FONT></TD>
    <TD STYLE="vertical-align: top; font-family: Times New Roman,serif">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; font-family: Times New Roman,serif">&nbsp;</TD></TR>
<TR>
    <TD STYLE="vertical-align: bottom; font-family: Times New Roman,serif">&nbsp;</TD>
    <TD STYLE="vertical-align: top; font-family: Times New Roman,serif">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; font-family: Times New Roman,serif">&nbsp;</TD></TR>
<TR>
    <TD STYLE="vertical-align: bottom; border-bottom: windowtext 1pt solid; font-family: Times New Roman,serif"><FONT STYLE="font-size: 10pt">/s/ Frederic H. Moll, M.D.</FONT></TD>
    <TD STYLE="vertical-align: top; font-family: Times New Roman,serif">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; font-family: Times New Roman,serif"><FONT STYLE="font-size: 10pt">Director</FONT></TD></TR>
<TR>
    <TD STYLE="vertical-align: bottom; font-family: Times New Roman,serif"><FONT STYLE="font-size: 10pt">Frederic H. Moll, M.D.</FONT></TD>
    <TD STYLE="vertical-align: top; font-family: Times New Roman,serif">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; font-family: Times New Roman,serif">&nbsp;</TD></TR>
<TR>
    <TD STYLE="vertical-align: bottom; font-family: Times New Roman,serif">&nbsp;</TD>
    <TD STYLE="vertical-align: top; font-family: Times New Roman,serif">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; font-family: Times New Roman,serif">&nbsp;</TD></TR>
<TR>
    <TD STYLE="vertical-align: bottom; border-bottom: windowtext 1pt solid; font-family: Times New Roman,serif"><FONT STYLE="font-size: 10pt">/s/ William D. Pruitt</FONT></TD>
    <TD STYLE="vertical-align: top; font-family: Times New Roman,serif">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; font-family: Times New Roman,serif"><FONT STYLE="font-size: 10pt">Director</FONT></TD></TR>
<TR>
    <TD STYLE="vertical-align: bottom; font-family: Times New Roman,serif"><FONT STYLE="font-size: 10pt">William D. Pruitt</FONT></TD>
    <TD STYLE="vertical-align: top; font-family: Times New Roman,serif">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; font-family: Times New Roman,serif">&nbsp;</TD></TR>
<TR>
    <TD STYLE="vertical-align: bottom; font-family: Times New Roman,serif">&nbsp;</TD>
    <TD STYLE="vertical-align: top; font-family: Times New Roman,serif">&nbsp;</TD>
    <TD STYLE="vertical-align: top; font-family: Times New Roman,serif">&nbsp;</TD></TR>
<TR>
    <TD STYLE="vertical-align: bottom; border-bottom: windowtext 1pt solid; font-family: Times New Roman,serif"><FONT STYLE="font-size: 10pt">/s/ Richard R. Pettingill</FONT></TD>
    <TD STYLE="vertical-align: top; font-family: Times New Roman,serif">&nbsp;</TD>
    <TD STYLE="vertical-align: top; font-family: Times New Roman,serif"><FONT STYLE="font-size: 10pt">Director </FONT></TD></TR>
<TR>
    <TD STYLE="vertical-align: bottom; font-family: Times New Roman,serif"><FONT STYLE="font-size: 10pt">Richard R. Pettingill</FONT></TD>
    <TD STYLE="vertical-align: top; font-family: Times New Roman,serif">&nbsp;</TD>
    <TD STYLE="vertical-align: top; font-family: Times New Roman,serif">&nbsp;</TD></TR>
</TABLE>

<P STYLE="font: 10pt Times New Roman,serif; margin: 0 0 12pt; text-align: center">&nbsp;</P>


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<P STYLE="font: 10pt Times New Roman,serif; margin: 0 0 12pt; text-align: center"><B>EXHIBIT INDEX</B></P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="width: 100%; border-collapse: collapse; font-size: 10pt">
<TR STYLE="vertical-align: bottom">
    <TD STYLE="width: 11%; font-family: Times New Roman,serif; text-align: center"><FONT STYLE="font-size: 10pt">Exhibit <U>Number</U></FONT></TD>
    <TD STYLE="width: 89%; font-family: Times New Roman,serif; text-decoration: underline; text-align: center"><FONT STYLE="font-size: 10pt"><U>Document Description</U></FONT></TD></TR>
<TR STYLE="vertical-align: bottom">
    <TD STYLE="font-family: Times New Roman,serif; text-align: center">&nbsp;</TD>
    <TD STYLE="font-family: Times New Roman,serif">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom">
    <TD STYLE="font-family: Times New Roman,serif; text-align: center"><FONT STYLE="font-size: 10pt">4</FONT></TD>
    <TD STYLE="font-family: Times New Roman,serif"><FONT STYLE="font-size: 10pt">MAKO Surgical Corp. 2008 Omnibus Incentive Plan (1)</FONT></TD></TR>
<TR STYLE="vertical-align: bottom">
    <TD STYLE="font-family: Times New Roman,serif; text-align: center">&nbsp;</TD>
    <TD STYLE="font-family: Times New Roman,serif">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom">
    <TD STYLE="font-family: Times New Roman,serif; text-align: center"><FONT STYLE="font-size: 10pt">5</FONT></TD>
    <TD STYLE="font-family: Times New Roman,serif"><FONT STYLE="font-size: 10pt">Opinion of Foley &amp; Lardner LLP (including consent of counsel) (2)</FONT></TD></TR>
<TR STYLE="vertical-align: bottom">
    <TD STYLE="font-family: Times New Roman,serif; text-align: center">&nbsp;</TD>
    <TD STYLE="font-family: Times New Roman,serif">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom">
    <TD STYLE="font-family: Times New Roman,serif; text-align: center"><FONT STYLE="font-size: 10pt">23.1</FONT></TD>
    <TD STYLE="font-family: Times New Roman,serif"><FONT STYLE="font-size: 10pt">Consent of Foley &amp; Lardner LLP (filed as part of Exhibit (5)) (2)</FONT></TD></TR>
<TR STYLE="vertical-align: bottom">
    <TD STYLE="font-family: Times New Roman,serif; text-align: center">&nbsp;</TD>
    <TD STYLE="font-family: Times New Roman,serif">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom">
    <TD STYLE="font-family: Times New Roman,serif; text-align: center"><FONT STYLE="font-size: 10pt">23.2</FONT></TD>
    <TD STYLE="font-family: Times New Roman,serif"><FONT STYLE="font-size: 10pt">Consent of Independent Registered Public Accounting Firm (2)</FONT></TD></TR>
<TR STYLE="vertical-align: bottom">
    <TD STYLE="font-family: Times New Roman,serif; text-align: center">&nbsp;</TD>
    <TD STYLE="font-family: Times New Roman,serif">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom">
    <TD STYLE="font-family: Times New Roman,serif; text-align: center"><FONT STYLE="font-size: 10pt">24</FONT></TD>
    <TD STYLE="font-family: Times New Roman,serif"><FONT STYLE="font-size: 10pt">Powers of Attorney (included on the signature page hereto)</FONT></TD></TR>
</TABLE>
<P STYLE="font: 10pt Times New Roman,serif; margin: 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman,serif; margin: 0">Documents incorporated by reference to filings made by MAKO Surgical Corp.
under the Securities Exchange Act of 1934, as amended, are under Securities and Exchange Commission (&ldquo;SEC&rdquo;) File No.
001-33966.</P>

<P STYLE="font: 10pt Times New Roman,serif; margin: 0 0 12pt">____________________________________</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman,serif; margin-top: 0; margin-bottom: 0"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0"></TD><TD STYLE="width: 12pt">(1)&nbsp;&nbsp;</TD><TD>Incorporated by reference to Appendix A to the Registrant&rsquo;s Definitive Proxy Statement on Schedule 14A filed with the
SEC on April 27, 2012 (File No. 001-33966).</TD></TR></TABLE>

<P STYLE="font: 10pt Times New Roman,serif; margin: 0 0 0 12pt; text-indent: -12pt">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="width: 100%; font: 10pt Times New Roman,serif; margin-top: 0; margin-bottom: 0"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0"></TD><TD STYLE="width: 12pt; text-align: left">(2)&nbsp;&nbsp;</TD><TD>Filed herewith.</TD>
</TR></TABLE>

<P STYLE="font: 10pt Times New Roman,serif; margin: 0 0 0 12pt; text-indent: -12pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman,serif; margin: 0 0 0 12pt; text-indent: -12pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman,serif; margin: 0 0 0 12pt; text-indent: -12pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman,serif; margin: 0 0 0 12pt; text-indent: -12pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman,serif; margin: 0 0 0 12pt; text-indent: -12pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman,serif; margin: 0 0 0 12pt; text-indent: -12pt">&nbsp;</P>

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<P STYLE="font: 10pt Times New Roman,serif; margin: 0 0 0 12pt; text-indent: -12pt">&nbsp;</P>

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{"company-data": {"conformed-name": "MAKO Surgical Corp.", "cik": "0001411861", "assigned-sic": "3842", "irs-number": "201901148", "state-of-incorporation": "DE", "fiscal-year-end": "1231"}, "filing-values": {"form-type": "S-8", "act": "33", "file-number": "333-186968", "film-number": "13653305"}, "business-address": {"street1": "2555 DAVIE ROAD", "city": "FT. LAUDERDALE", "state": "FL", "zip": "33317", "phone": "954-927-2044"}, "mail-address": {"street1": "2555 DAVIE ROAD", "city": "FT. LAUDERDALE", "state": "FL", "zip": "33317"}}
As filed with the United States Securities and
Exchange Commission on February 28, 2013
Registration No. 333-________
UNITED STATES
SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
_________________
FORM S-8
REGISTRATION STATEMENT
Under
THE SECURITIES ACT OF 1933
___________________
MAKO Surgical Corp.
(Exact name of registrant as specified in its charter)
Delaware
20-1901148
(State or Other Jurisdiction of
Incorporation or Organization)
(I.R.S. Employer
Identification No.)
2555 Davie Road
Fort Lauderdale, Florida 33317
(Address, Including Zip Code, of Principal Executive
Offices)
___________________
MAKO Surgical Corp. 2008 Omnibus Incentive Plan
(Full Title of the Plan)
___________________
Maurice R. Ferré, M.D.
President and Chief Executive Officer
MAKO Surgical Corp.
2555 Davie Road, Fort Lauderdale, Florida 33317
(954) 927-2044
(Name, Address and Telephone Number, Including Area Code, of Agent for Service)
COPY TO:
Jay O. Rothman, Esq.
Foley & Lardner LLP
777 East Wisconsin Avenue
Milwaukee, Wisconsin 53202
(414) 271-2400
Indicate
by check mark whether the registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer or a smaller reporting
company. See the definition of "large accelerated filer," "accelerated filer" and "smaller reporting
company" in Rule 12b-2 of the Exchange Act. (Check one):
Large accelerated filer
☒
Accelerated filer
☐
Non-accelerated filer
☐
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CALCULATION OF REGISTRATION FEE
Title of Securities
To Be Registered
Amount
To Be
Registered
(1)
Proposed
Maximum
Offering Price
Per Unit
(2)
Proposed
Maximum
Aggregate Offering
Price
(2)
Amount of
Registration Fee
Common Stock,
par value $0.001 per share
1,880,930
$11.19
$21,047,606.70
$2,870.89
(1)
This Registration Statement covers, in addition to the number of
shares of Common Stock stated above, options and other rights to purchase or acquire the shares of Common Stock covered by the
prospectus of the above-named plan, and, pursuant to Rule 416 under the Securities Act of 1933, as amended (the "Securities
Act"), any additional shares of Common Stock which become issuable under the above-named plan by reason of any stock dividend,
stock split, recapitalization or other similar transaction effected without the receipt of consideration which results in an increase
in the number of outstanding shares of Common Stock.
(2)
Pursuant to Rule 457(h) and (c) promulgated under the Securities
Act, the maximum offering price, per share and in the aggregate, and the registration fee were calculated based upon the average
of the high and low prices of the Common Stock on February 26, 2013, as reported on the NASDAQ Global Select Market.
Pursuant to Rule 429 under the Securities Act, the Prospectus referred to
herein also relates to the Registrant's Registration Statements on Form S-8 filed with the Securities and Exchange Commission
on February 28, 2008 (Registration No. 333-149445), March 12, 2009 (Registration No. 333-157889), March 10, 2010 (Registration
No. 333-165386), March 10, 2011 (Registration No. 333-172732), and March 8, 2012 (Registration No. 333-179992).
STATEMENT PURSUANT TO GENERAL
INSTRUCTION E TO FORM S-8
The purpose of this Registration
Statement is to register 1,880,930 additional shares of Common Stock, $.001 par value per share ("Common Stock"), of
MAKO Surgical Corp. (the "Company") in connection with the MAKO Surgical Corp. 2008 Omnibus Incentive Plan.
Pursuant to General Instruction
E of Form S-8, the contents of the Company's Registration Statements on Form S-8 filed with the Securities and Exchange Commission
on February 28, 2008 (Registration No. 333-149445), March 12, 2009 (Registration No. 333-157889), March 10, 2010 (Registration
No. 333-165386), March 10, 2011 (Registration No. 333-172732), and March 8, 2012 (Registration No. 333-179992), including the documents
incorporated by reference therein, are incorporated by reference into this Registration Statement, except as set forth below.
PART II
INFORMATION REQUIRED IN THE
REGISTRATION STATEMENT
Item 8.
Exhibits
.
The exhibits filed herewith or incorporated herein
by reference are set forth in the attached Exhibit Index.
Item 9.
Undertakings
.
(a)         The
undersigned Registrant hereby undertakes:
(1)     To
file, during any period in which offers or sales are being made, a post-effective amendment to this Registration Statement:
(i)      To include any prospectus required by Section 10(a)(3) of the Securities Act of 1933;
(ii)     To reflect in the prospectus any facts or events arising after the effective date of the Registration Statement (or the most recent post-effective amendment thereof) which, individually or in the aggregate, represent a fundamental change in the information set forth in the Registration Statement;
(iii)    To include any material information with respect to the plan of distribution not previously disclosed in the Registration Statement or any material change to such information in the Registration Statement;
provided, however,
that paragraphs (a)(1)(i)
and (a)(1)(ii) do not apply if the information required to be included in a post-effective amendment by those paragraphs is contained
in reports filed with or furnished to the Securities and Exchange Commission by the Registrant pursuant to Section 13 or Section 15(d)
of the Securities Exchange Act of 1934 that are incorporated by reference in the Registration Statement.
(2)     That,
for the purpose of determining any liability under the Securities Act of 1933, each such post-effective amendment shall be deemed
to be a new registration statement relating to the securities offered herein, and the offering of such securities at that time
shall be deemed to be the initial bona fide offering thereof.
(3)     To
remove from registration by means of a post-effective amendment any of the securities being registered which remain unsold at the
termination of the offering.
1
(4)     That,
for the purpose of determining liability of the registrant under the Securities Act of 1933 to any purchaser in the initial distribution
of the securities, in a primary offering of securities of the Registrant pursuant to this Registration Statement, regardless of
the underwriting method used to sell the securities to the purchaser, if the securities are offered or sold to such purchaser by
means of any of the following communications, the Registrant will be a seller to the purchaser and will be considered to offer
or sell such securities to such purchaser:
(i)      Any preliminary prospectus or prospectus of the Registrant relating to the offering required to be filed pursuant to Rule 424 under the Securities Act of 1933;
(ii)     Any free writing prospectus relating to the offering prepared by or on behalf of the Registrant or used or referred to by the Registrant;
(iii)    The portion of any other free writing prospectus relating to the offering containing material information about the Registrant or its securities provided by or on behalf of the Registrant; and
(iv)    Any other communication that is an offer in the offering made by the Registrant to the purchaser.
(b)         The
undersigned Registrant hereby undertakes that, for purposes of determining any liability under the Securities Act of 1933, each
filing of the Registrant's annual report pursuant to Section 13(a) or Section 15(d) of the Securities Exchange Act of 1934
that is incorporated by reference in this Registration Statement shall be deemed to be a new registration statement relating to
the securities offered herein, and the offering of such securities at that time shall be deemed to be the initial bona fide offering
thereof.
(c)         Insofar
as indemnification for liabilities arising under the Securities Act of 1933 may be permitted to directors, officers and controlling
persons of the Registrant pursuant to the foregoing provisions, or otherwise, the Registrant has been advised that in the opinion
of the Commission such indemnification is against public policy as expressed in the Act and is, therefore, unenforceable. In the
event that a claim for indemnification against such liabilities (other than the payment by the Registrant of expenses incurred
or paid by a director, officer or controlling person of the Registrant in the successful defense of any action, suit or proceeding)
is asserted by such director, officer or controlling person in connection with the securities being registered, the Registrant
will, unless in the opinion of its counsel the matter has been settled by controlling precedent, submit to a court of appropriate
jurisdiction the question whether such indemnification by it is against public policy as expressed in the Act and will be governed
by the final adjudication of such issue.
2
SIGNATURES
Pursuant
to the requirements of the Securities Act of 1933, the Registrant certifies that it has reasonable grounds to believe that it meets
all of the requirements for filing on Form S-8 and has duly caused this Registration Statement to be signed on its behalf
by the undersigned, thereunto duly authorized, in the City of Fort Lauderdale, State of Florida, on this 28th day of February,
2013.
MAKO Surgical Corp.
By:
/s/ Maurice R. Ferré, M.D.
Maurice R. Ferré, M.D.
President and Chief Executive Officer and
Chairman of the Board
Each person whose signature appears below constitutes and appoints Maurice
R. Ferré and Fritz L. LaPorte, and each of them individually, his true and lawful attorney-in-fact and agent, with full
powers of substitution and resubstitution, for him and in his name, place and stead, in any and all capacities, to sign any and
all amendments (including post-effective amendments) to this Registration Statement, and to file the same, with all exhibits thereto,
and other documents in connection therewith, with the Securities and Exchange Commission, granting unto said attorneys-in-fact
and agents, and each of them individually, full power and authority to do and perform each and every act and thing requisite and
necessary to be done in and about the premises, as fully to all intents and purposes as he or she might or could do in person,
hereby ratifying and confirming all that said attorneys-in-fact and agents, or any of them individually, or their substitute or
substitutes, may lawfully do or cause to be done by virtue hereof.
Pursuant to the requirements of the Securities Act, this Registration Statement
has been signed below by the following persons in the capacities indicated below on February 28, 2013.
Signature
Title
/s/ Maurice R. Ferré, M.D.
Chief Executive Officer, President and Chairman of the Board
Maurice R. Ferré, M.D.
(Principal Executive Officer)
/s/ Fritz L. LaPorte
Senior Vice President of Finance and Administration, Chief
Financial Officer and Treasurer (Principal Financial Officer and
Fritz L. LaPorte
Principal Accounting Officer)
/s/ S. Morry Blumenfeld, Ph.D.
Director
S. Morry Blumenfeld, Ph.D.
/s/ Christopher C. Dewey
Director
Christopher C. Dewey
/s/ Charles W. Federico
Director
Charles W. Federico
/s/ John G. Freund, M.D.
Director
John G. Freund, M.D.
/s/ Frederic H. Moll, M.D.
Director
Frederic H. Moll, M.D.
/s/ William D. Pruitt
Director
William D. Pruitt
/s/ Richard R. Pettingill
Director
Richard R. Pettingill
S-
1
EXHIBIT INDEX
Exhibit
Number
Document Description
4
MAKO Surgical Corp. 2008 Omnibus Incentive Plan (1)
5
Opinion of Foley & Lardner LLP (including consent of counsel) (2)
23.1
Consent of Foley & Lardner LLP (filed as part of Exhibit (5)) (2)
23.2
Consent of Independent Registered Public Accounting Firm (2)
24
Powers of Attorney (included on the signature page hereto)
Documents incorporated by reference to filings made by MAKO Surgical Corp.
under the Securities Exchange Act of 1934, as amended, are under Securities and Exchange Commission ("SEC") File No.
001-33966.
____________________________________
(1)
Incorporated by reference to Appendix A to the Registrant's Definitive Proxy Statement on Schedule 14A filed with the
SEC on April 27, 2012 (File No. 001-33966).
(2)
Filed herewith.