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<TITLE>Form S-8, 11/13/01</TITLE>
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<P>As filed with the Securities and Exchange Commission on November 15, 2001</TD>
<TD WIDTH="27%" VALIGN="TOP">
<P ALIGN="CENTER">Registration No. 333-</TD>
</TR>
</TABLE>

<P ALIGN="CENTER">&nbsp;</P><DIR>
<DIR>
<DIR>

<B><FONT SIZE=5><P ALIGN="CENTER">SECURITIES AND EXCHANGE COMMISSION</P>
</B></FONT><P ALIGN="CENTER">Washington, D.C. 20549</P>
<U><P ALIGN="CENTER">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; </P></DIR>
</DIR>
</DIR>

</U><B><FONT SIZE=5><P ALIGN="CENTER">FORM S-8</P>
</B></FONT><P ALIGN="CENTER">REGISTRATION STATEMENT</P>
<P ALIGN="CENTER">UNDER</P>
<P ALIGN="CENTER">THE SECURITIES ACT OF 1933</P>
<U><FONT SIZE=2><P ALIGN="CENTER">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; </P><DIR>
<DIR>
<DIR>

</U></FONT><B><FONT SIZE=5><P ALIGN="CENTER">NaPro BioTherapeutics, Inc.</P>
</B></FONT><FONT SIZE=1><P ALIGN="CENTER">(Exact name of registrant as specified in its charter)</P></DIR>
</DIR>
</DIR>
</FONT>
<TABLE CELLSPACING=0 BORDER=0 CELLPADDING=7 WIDTH=870>
<TR><TD WIDTH="33%" VALIGN="TOP">
<P ALIGN="CENTER">Delaware</TD>
<TD WIDTH="33%" VALIGN="TOP">
<P>&nbsp;</TD>
<TD WIDTH="33%" VALIGN="TOP">
<P ALIGN="CENTER">84-1187753 </TD>
</TR>
<TR><TD WIDTH="33%" VALIGN="TOP">
<FONT SIZE=1><P ALIGN="CENTER">(State of Incorporation)</FONT></TD>
<TD WIDTH="33%" VALIGN="TOP">
<P>&nbsp;</TD>
<TD WIDTH="33%" VALIGN="TOP">
<FONT SIZE=1><P ALIGN="CENTER">(I.R.S. Employer Identification No.)</FONT></TD>
</TR>
</TABLE>

<FONT SIZE=2><P ALIGN="CENTER">6304 Spine Road, Unit A<BR>
Boulder, Colorado 80301<BR>
Telephone: (303) 530-3891<BR>
</FONT><FONT SIZE=1>(Address of principal executive offices)</P>
</FONT><U><FONT SIZE=2><P ALIGN="CENTER">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; </P>
</U><P ALIGN="CENTER">NaPro BioTherapeutics, Inc.<BR>
1994 Long-Term Performance Incentive Plan</P>
<P ALIGN="CENTER">1998 Stock Incentive Plan</P>
<P ALIGN="CENTER">of NaPro BioTherapeutics, Inc.</P>
</FONT><FONT SIZE=1><P ALIGN="CENTER">(Full title of the plans)</P>
</FONT><FONT SIZE=2><P ALIGN="CENTER">Gordon H. Link, Jr.<BR>
Chief Financial Officer<BR>
6304 Spine Road, Unit A<BR>
Boulder, Colorado 80301<BR>
Telephone: (303) 530-3891<BR>
Telecopier: (303) 530-1296<BR>
</FONT><FONT SIZE=1>(Name, address, including zip code, and telephone number, including area code, of agent for service)</P>
</FONT><U><FONT SIZE=2><P ALIGN="CENTER">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</P>
</U><P ALIGN="CENTER">Copies to:</P>
<P ALIGN="CENTER">Francis R. Wheeler, Esq.<BR>
Cooley Godward LLP<BR>
380 Interlocken Crescent, Suite 900<BR>
Broomfield, Colorado 80021-8023<BR>
Telephone: (720) 566-4000<BR>
Telecopier: (720) 566-4099<BR>
<U>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</P>
</U><B><P ALIGN="CENTER">CALCULATION OF REGISTRATION FEE</P></B></FONT>
<TABLE BORDER CELLSPACING=1 CELLPADDING=7 WIDTH=686>
<TR><TD WIDTH="20%" VALIGN="BOTTOM">
<P ALIGN="CENTER"><B><FONT SIZE=1>Title of Securities <BR>
to be Registered</B></FONT></TD>
<TD WIDTH="20%" VALIGN="BOTTOM">
<B><FONT SIZE=1><P ALIGN="CENTER">Amount to be Registered</B></FONT></TD>
<TD WIDTH="20%" VALIGN="BOTTOM">
<B><FONT SIZE=1><P ALIGN="CENTER">Proposed Maximum<BR>
Offering<BR>
Price per Share (1)</B></FONT></TD>
<TD WIDTH="20%" VALIGN="BOTTOM">
<B><FONT SIZE=1><P ALIGN="CENTER">Proposed Maximum<BR>
Aggregate<BR>
Offering Price (1)</B></FONT></TD>
<TD WIDTH="20%" VALIGN="BOTTOM">
<B><FONT SIZE=1><P ALIGN="CENTER">Amount of<BR>
Registration Fee</B></FONT></TD>
</TR>
<TR><TD WIDTH="20%" VALIGN="BOTTOM" HEIGHT=31>
<FONT SIZE=1><P ALIGN="CENTER">Common Stock and Stock Options <BR>
(par value $.0075)</FONT></TD>
<TD WIDTH="20%" VALIGN="BOTTOM" HEIGHT=31>
<FONT SIZE=1><P ALIGN="CENTER">1,825,000 shares</FONT></TD>
<TD WIDTH="20%" VALIGN="BOTTOM" HEIGHT=31>
<FONT SIZE=1><P ALIGN="CENTER">$9.07</FONT></TD>
<TD WIDTH="20%" VALIGN="BOTTOM" HEIGHT=31>
<FONT SIZE=1><P ALIGN="CENTER">$16,560,627.43</FONT></TD>
<TD WIDTH="20%" VALIGN="BOTTOM" HEIGHT=31>
<FONT SIZE=1><P ALIGN="CENTER">$4,140.16</FONT></TD>
</TR>
</TABLE>

<OL>

<FONT SIZE=1><P ALIGN="JUSTIFY"><LI>Estimated solely for the purpose of calculating the amount of the registration fee pursuant to Rules 457(c) and (h)(1) under the Securities Act of 1933, as amended (the "Securities Act"). The price per share and aggregate offering price are based upon (i) the weighted average exercise price of options outstanding and (ii) the average of the high and low prices of the Registrant's Common Stock on November 8, 2001 as reported on Nasdaq National Market. The following chart illustrates our calculation of the registration fee:</LI></P></OL>
</FONT>
<TABLE BORDER CELLSPACING=1 CELLPADDING=7 WIDTH=685>
<TR><TD WIDTH="28%" VALIGN="TOP">
<P ALIGN="CENTER"><B><FONT SIZE=1>Type of Shares</B></FONT></TD>
<TD WIDTH="18%" VALIGN="TOP">
<B><FONT SIZE=1><P ALIGN="CENTER">Number of Shares</B></FONT></TD>
<TD WIDTH="23%" VALIGN="TOP">
<B><FONT SIZE=1><P ALIGN="CENTER">Offering Price Per Share</B></FONT></TD>
<TD WIDTH="30%" VALIGN="TOP">
<B><FONT SIZE=1><P ALIGN="CENTER">Aggregate Offering Price</B></FONT></TD>
</TR>
<TR><TD WIDTH="28%" VALIGN="TOP">
<FONT SIZE=1><P>Shares issuable pursuant to options outstanding under the 1994 Long-Term Performance Incentive Plan </FONT></TD>
<TD WIDTH="18%" VALIGN="TOP">
<FONT SIZE=1><P ALIGN="CENTER">&nbsp;</P>
<P ALIGN="CENTER">785,791</FONT></TD>
<TD WIDTH="23%" VALIGN="TOP">
<STRIKE><FONT SIZE=1><P ALIGN="CENTER">&nbsp;</P>
</STRIKE><P ALIGN="CENTER">$9.49(a)</FONT></TD>
<TD WIDTH="30%" VALIGN="TOP">
<STRIKE><FONT SIZE=1><P ALIGN="CENTER">&nbsp;</P>
</STRIKE><P ALIGN="CENTER">$7,457,156.59</FONT></TD>
</TR>
<TR><TD WIDTH="28%" VALIGN="TOP">
<FONT SIZE=1><P>Shares issuable under the 1994 Long-Term Performance Incentive Plan</FONT></TD>
<TD WIDTH="18%" VALIGN="TOP">
<STRIKE><FONT SIZE=1><P ALIGN="CENTER"><BR>
</STRIKE>539,209</FONT></TD>
<TD WIDTH="23%" VALIGN="TOP">
<STRIKE><FONT SIZE=1><P ALIGN="CENTER"><BR>
</STRIKE>$8.76(b)</FONT></TD>
<TD WIDTH="30%" VALIGN="TOP">
<FONT SIZE=1><P ALIGN="CENTER"><BR>
$4,723,470.84</FONT></TD>
</TR>
<TR><TD WIDTH="28%" VALIGN="TOP">
<FONT SIZE=1><P>Shares issuable under the 1998 Stock Incentive Plan</FONT></TD>
<TD WIDTH="18%" VALIGN="TOP">
<FONT SIZE=1><P ALIGN="CENTER"><BR>
500,000</FONT></TD>
<TD WIDTH="23%" VALIGN="TOP">
<FONT SIZE=1><P ALIGN="CENTER"><BR>
$8.76(b)</FONT></TD>
<TD WIDTH="30%" VALIGN="MIDDLE">
<FONT SIZE=1><P ALIGN="CENTER"><BR>
$4,380,000.00</FONT></TD>
</TR>
</TABLE>

<OL TYPE="a">
<OL TYPE="a">

<FONT SIZE=1><P ALIGN="JUSTIFY"><LI>Based on the weighted average exercise price of options outstanding.</LI></P>
<P ALIGN="JUSTIFY"><LI>Based on the average of the high and low prices of the Registrant's Common Stock on November 8, 2001 as reported on Nasdaq National Market.</LI></P></OL>
</OL>

</FONT><P ALIGN="JUSTIFY">&nbsp;</P>
<P ALIGN="JUSTIFY">&nbsp;</P>
<B><P ALIGN="CENTER">INCORPORATION BY REFERENCE </P>
</B><P ALIGN="JUSTIFY">The following documents filed by NaPro Biotherapeutics, Inc. a Delaware corporation (the "Company" or the "Registrant"), with the Securities and Exchange Commission (the "Commission") are incorporated by reference into this Registration Statement:</P>
<OL TYPE="a">
<OL TYPE="a">

<P ALIGN="JUSTIFY"><LI>The Registration Statement on Form&nbsp;S-8 No.&nbsp;333-52008, filed December 15, 2000;</LI></P>
<P ALIGN="JUSTIFY"><LI>The Company's latest annual report on Form 10-K for the fiscal year ended December 31, 2000;</LI></P>
<P ALIGN="JUSTIFY"><LI>The Company's quarterly report on Form 10-Q for the quarter ended March 31, 2001; </LI></P>
<P ALIGN="JUSTIFY"><LI>The Company's quarterly report on Form 10-Q for the quarter ended June 30, 2001;</LI></P>
<P ALIGN="JUSTIFY"><LI>The Company's quarterly report on Form 10-Q for the quarter ended September 30, 2001;</LI></P>
<P ALIGN="JUSTIFY"><LI>A description of the Company's Common Stock, which is contained in the Form 8-A Registration Statement filed on June 13, 1994, as amended; </LI></P>
<P ALIGN="JUSTIFY"><LI>A description of the Company's preferred stock purchase rights, which is contained in the Form 8-A Registration Statement filed on November 29, 1996, as amended by the Form 8-A12G/A filed on October 23, 2001; and </LI></P>
<P ALIGN="JUSTIFY"><LI>All reports and other documents subsequently filed by the Company pursuant to Sections 13(a), 13(c), 14, and 15(d) of the Securities Exchange Act of 1934, as amended (the "Exchange Act"), prior to the filing of a post effective amendment which indicates that all securities offered have been sold or which deregisters all securities then remaining unsold, shall be deemed to be incorporated by reference herein and to be a part of this registration statement from the date of the filing of such reports and documents.</LI></P></OL>
</OL>

<P>&nbsp;</P>
<B><FONT SIZE=2><P ALIGN="CENTER">EXHIBITS</P></B></FONT>
<TABLE CELLSPACING=0 BORDER=0 CELLPADDING=7 WIDTH=637>
<TR><TD WIDTH="11%" VALIGN="BOTTOM">
<P ALIGN="JUSTIFY"><B><FONT SIZE=2>Exhibit</P>
<P ALIGN="JUSTIFY">Number</B></FONT></TD>
<TD WIDTH="89%" VALIGN="TOP">
<P>&nbsp;</TD>
</TR>
<TR><TD WIDTH="11%" VALIGN="TOP">
<FONT SIZE=2><P ALIGN="JUSTIFY">5</FONT></TD>
<TD WIDTH="89%" VALIGN="TOP"><DIR>

<FONT SIZE=2><P ALIGN="JUSTIFY">Opinion of Cooley Godward LLP </DIR>
</FONT></TD>
</TR>
<TR><TD WIDTH="11%" VALIGN="TOP">
<FONT SIZE=2><P ALIGN="JUSTIFY">23.1</FONT></TD>
<TD WIDTH="89%" VALIGN="TOP"><DIR>

<FONT SIZE=2><P ALIGN="JUSTIFY">Consent of Ernst &amp; Young LLP </DIR>
</FONT></TD>
</TR>
<TR><TD WIDTH="11%" VALIGN="TOP">
<FONT SIZE=2><P ALIGN="JUSTIFY">23.2</FONT></TD>
<TD WIDTH="89%" VALIGN="TOP"><DIR>

<FONT SIZE=2><P ALIGN="JUSTIFY">Consent of Cooley Godward LLP is contained in Exhibit&nbsp;5 to this Registration Statement</DIR>
</FONT></TD>
</TR>
<TR><TD WIDTH="11%" VALIGN="TOP">
<FONT SIZE=2><P ALIGN="JUSTIFY">24</FONT></TD>
<TD WIDTH="89%" VALIGN="TOP"><DIR>

<FONT SIZE=2><P ALIGN="JUSTIFY">Power of Attorney is contained on the signature pages.</DIR>
</FONT></TD>
</TR>
</TABLE>

<P ALIGN="CENTER">&nbsp;</P>
<B><P ALIGN="CENTER">SIGNATURES</P>
</B><FONT SIZE=2><P ALIGN="JUSTIFY">Pursuant to the requirements of the Securities Act of 1933, as amended, the Registrant certifies that it has reasonable grounds to believe that it meets all of the requirements for filing on Form&nbsp;S-8 and has duly caused this Registration Statement to be signed on its behalf by the undersigned, thereunto duly authorized, in the City of Boulder, State of Colorado, on November 13, 2001.</P><DIR>
<DIR>
<DIR>
<DIR>
<DIR>
<DIR>
<DIR>
<DIR>
<DIR>
<DIR>
<DIR>
<DIR>
<DIR>
<DIR>

<B><P ALIGN="JUSTIFY">NaPro BioTherapeutics, Inc.</P>
</B><P ALIGN="JUSTIFY">By: s/ Kai Larson</P>
<P ALIGN="JUSTIFY">Title: Vice President, General Counsel</P></DIR>
</DIR>
</DIR>
</DIR>
</DIR>
</DIR>
</DIR>
</DIR>
</DIR>
</DIR>
</DIR>
</DIR>
</DIR>
</DIR>

<B><P ALIGN="CENTER">POWER OF ATTORNEY</P>
<P ALIGN="JUSTIFY">Know All Persons By These Presents</B>, that each person whose signature appears below constitutes and appoints Gordon H. Link, Jr. and Robert L. Poley, and each or any one of them, his true and lawful attorney-in-fact and agent, with full power of substitution and resubstitution, for him and in his name, place and stead, in any and all capacities, to sign any and all amendments (including post-effective amendments) to this Registration Statement, and to file the same, with all exhibits thereto, and other documents in connection therewith, with the Securities and Exchange Commission, granting unto said attorneys-in-fact and agents, and each of them, full power and authority to do and perform each and every act and thing requisite and necessary to be done in connection therewith, as fully to all intents and purposes as he might or could do in person, hereby ratifying and confirming all that said attorneys-in-fact and agents, or any of them, or their or his substitutes or substitute, may lawfully do or cause to be done by virtue hereof.</P>
<P ALIGN="JUSTIFY">&nbsp;</P>
<P ALIGN="JUSTIFY">Pursuant to the requirements of the Securities Act of 1933, this Registration Statement has been signed by the following persons in the capacities and on the dates indicated. </P></FONT>
<TABLE CELLSPACING=0 BORDER=0 CELLPADDING=24 WIDTH=696>
<TR><TD WIDTH="41%" VALIGN="TOP">
<P ALIGN="CENTER"><B><FONT SIZE=2>Signature</B></FONT></TD>
<TD WIDTH="34%" VALIGN="TOP"><DIR>

<B><FONT SIZE=2><P ALIGN="CENTER">Title</DIR>
</B></FONT></TD>
<TD WIDTH="24%" VALIGN="TOP">
<B><FONT SIZE=2><P ALIGN="CENTER">Date</B></FONT></TD>
</TR>
<TR><TD WIDTH="41%" VALIGN="TOP">
<U><FONT SIZE=2><P ALIGN="CENTER">/s/<BR>
</U>(Leonard P. Shaykin)</FONT></TD>
<TD WIDTH="34%" VALIGN="TOP"><DIR>

<FONT SIZE=2><P ALIGN="CENTER">Chairman of the Board<BR>
Chief Executive Officer </DIR>
</FONT></TD>
<TD WIDTH="24%" VALIGN="TOP">
<FONT SIZE=2><P ALIGN="JUSTIFY">November 12, 2001</FONT></TD>
</TR>
<TR><TD WIDTH="41%" VALIGN="TOP">
<U><FONT SIZE=2><P ALIGN="CENTER">/s/</U> <BR>
(Sterling Ainsworth)</FONT></TD>
<TD WIDTH="34%" VALIGN="TOP"><DIR>

<FONT SIZE=2><P ALIGN="CENTER">Vice Chairman<BR>
President<BR>
Chief Scientific Officer<BR>
Director</DIR>
</FONT></TD>
<TD WIDTH="24%" VALIGN="TOP">
<FONT SIZE=2><P ALIGN="JUSTIFY">November 12, 2001</FONT></TD>
</TR>
<TR><TD WIDTH="41%" VALIGN="TOP">
<U><FONT SIZE=2><P ALIGN="CENTER">/s/<BR>
</U>(Patricia A. Pilia, Ph.D.)</FONT></TD>
<TD WIDTH="34%" VALIGN="TOP"><DIR>

<FONT SIZE=2><P ALIGN="CENTER">Executive Vice President<BR>
Director</DIR>
</FONT></TD>
<TD WIDTH="24%" VALIGN="TOP">
<FONT SIZE=2><P ALIGN="JUSTIFY">November 12, 2001</FONT></TD>
</TR>
<TR><TD WIDTH="41%" VALIGN="TOP">
<U><FONT SIZE=2><P ALIGN="CENTER">/s/<BR>
</U>(Gordon H. Link, Jr.)</FONT></TD>
<TD WIDTH="34%" VALIGN="TOP"><DIR>

<FONT SIZE=2><P ALIGN="CENTER">Vice President<BR>
Chief Financial Officer<BR>
(Principal Financial Officer) </DIR>
</FONT></TD>
<TD WIDTH="24%" VALIGN="TOP">
<FONT SIZE=2><P ALIGN="JUSTIFY">November 12, 2001</FONT></TD>
</TR>
<TR><TD WIDTH="41%" VALIGN="TOP" HEIGHT=47>
<U><FONT SIZE=2><P ALIGN="CENTER">/s/<BR>
</U>(Robert L. Poley)</FONT></TD>
<TD WIDTH="34%" VALIGN="TOP" HEIGHT=47><DIR>

<FONT SIZE=2><P ALIGN="CENTER">Controller<BR>
(Principal Accounting Officer)</DIR>
</FONT></TD>
<TD WIDTH="24%" VALIGN="TOP" HEIGHT=47>
<FONT SIZE=2><P ALIGN="JUSTIFY">November 13, 2001</FONT></TD>
</TR>
<TR><TD WIDTH="41%" VALIGN="TOP">
<U><FONT SIZE=2><P ALIGN="CENTER">/s/<BR>
</U>(Edward L. Erickson)</FONT></TD>
<TD WIDTH="34%" VALIGN="TOP"><DIR>

<FONT SIZE=2><P ALIGN="CENTER"><BR>
Director</DIR>
</FONT></TD>
<TD WIDTH="24%" VALIGN="TOP">
<FONT SIZE=2><P ALIGN="JUSTIFY">November 13, 2001</FONT></TD>
</TR>
<TR><TD WIDTH="41%" VALIGN="TOP">
<U><FONT SIZE=2><P ALIGN="CENTER">/s/<BR>
</U>(Arthur H. Hayes, Jr., M.D.)</FONT></TD>
<TD WIDTH="34%" VALIGN="TOP"><DIR>

<FONT SIZE=2><P ALIGN="CENTER"><BR>
Director</DIR>
</FONT></TD>
<TD WIDTH="24%" VALIGN="TOP">
<FONT SIZE=2><P ALIGN="JUSTIFY">November 13, 2001</FONT></TD>
</TR>
<TR><TD WIDTH="41%" VALIGN="TOP">
<U><FONT SIZE=2><P ALIGN="CENTER">/s/<BR>
</U>(Marc J. Ostro, Ph.D.</FONT></TD>
<TD WIDTH="34%" VALIGN="TOP"><DIR>

<FONT SIZE=2><P ALIGN="CENTER"><BR>
Director</DIR>
</FONT></TD>
<TD WIDTH="24%" VALIGN="TOP">
<FONT SIZE=2><P ALIGN="JUSTIFY">November 12, 2001</FONT></TD>
</TR>
<TR><TD WIDTH="41%" VALIGN="TOP" HEIGHT=45>
<U><FONT SIZE=2><P ALIGN="CENTER">/s/<BR>
</U>(The Honorable Richard N. Perle)</FONT></TD>
<TD WIDTH="34%" VALIGN="TOP" HEIGHT=45><DIR>

<FONT SIZE=2><P ALIGN="CENTER"><BR>
Director</DIR>
</FONT></TD>
<TD WIDTH="24%" VALIGN="TOP" HEIGHT=45>
<FONT SIZE=2><P ALIGN="JUSTIFY">November 9, 2001</FONT></TD>
</TR>
<TR><TD WIDTH="41%" VALIGN="TOP" HEIGHT=45>
<U><FONT SIZE=2><P ALIGN="CENTER">/s/<BR>
</U>(Robert E. Pollack, Ph.D.)</FONT></TD>
<TD WIDTH="34%" VALIGN="TOP" HEIGHT=45><DIR>

<FONT SIZE=2><P ALIGN="CENTER"><BR>
Director</DIR>
</FONT></TD>
<TD WIDTH="24%" VALIGN="TOP" HEIGHT=45>
<FONT SIZE=2><P ALIGN="JUSTIFY">November 12, 2001</FONT></TD>
</TR>
</TABLE>

<FONT SIZE=2><P ALIGN="JUSTIFY">&nbsp;</P>
<P ALIGN="JUSTIFY">&nbsp;</P>
<P ALIGN="CENTER">&nbsp;</P>
<B><P ALIGN="CENTER">EXHIBIT INDEX</P></B></FONT>
<TABLE CELLSPACING=0 BORDER=0 CELLPADDING=7 WIDTH=1039>
<TR><TD WIDTH="6%" VALIGN="BOTTOM">
<P ALIGN="JUSTIFY"><B><FONT SIZE=2>Exhibit</P>
<P ALIGN="JUSTIFY">Number</B></FONT></TD>
<TD WIDTH="39%" VALIGN="TOP">
<P>&nbsp;</TD>
<TD WIDTH="55%" VALIGN="TOP">
<B><FONT SIZE=2><P ALIGN="JUSTIFY">Sequential Page Numbers</B></FONT></TD>
</TR>
<TR><TD WIDTH="6%" VALIGN="TOP">
<FONT SIZE=2><P ALIGN="JUSTIFY">5</FONT></TD>
<TD WIDTH="39%" VALIGN="TOP"><DIR>

<FONT SIZE=2><P ALIGN="JUSTIFY">Opinion of Cooley Godward LLP </DIR>
</FONT></TD>
<TD WIDTH="55%" VALIGN="TOP">
<P>&nbsp;</TD>
</TR>
<TR><TD WIDTH="6%" VALIGN="TOP">
<FONT SIZE=2><P ALIGN="JUSTIFY">23.1</FONT></TD>
<TD WIDTH="39%" VALIGN="TOP"><DIR>

<FONT SIZE=2><P ALIGN="JUSTIFY">Consent of Ernst &amp; Young LLP </DIR>
</FONT></TD>
<TD WIDTH="55%" VALIGN="TOP">
<P>&nbsp;</TD>
</TR>
<TR><TD WIDTH="6%" VALIGN="TOP">
<FONT SIZE=2><P ALIGN="JUSTIFY">23.2</FONT></TD>
<TD WIDTH="39%" VALIGN="TOP"><DIR>

<FONT SIZE=2><P ALIGN="JUSTIFY">Consent of Cooley Godward LLP is contained in Exhibit&nbsp;5 to this Registration Statement</DIR>
</FONT></TD>
<TD WIDTH="55%" VALIGN="TOP">
<P>&nbsp;</TD>
</TR>
<TR><TD WIDTH="6%" VALIGN="TOP">
<FONT SIZE=2><P ALIGN="JUSTIFY">24</FONT></TD>
<TD WIDTH="39%" VALIGN="TOP"><DIR>

<FONT SIZE=2><P ALIGN="JUSTIFY">Power of Attorney is contained on the signature pages.</DIR>
</FONT></TD>
<TD WIDTH="55%" VALIGN="TOP">
<P>&nbsp;</TD>
</TR>
</TABLE>

<P ALIGN="JUSTIFY"></P></BODY>
</HTML>
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{"company-data": {"conformed-name": "NAPRO BIOTHERAPEUTICS INC", "cik": "0000891504", "assigned-sic": "2833", "irs-number": "841187753", "state-of-incorporation": "DE", "fiscal-year-end": "1231"}, "filing-values": {"form-type": "S-8", "act": "33", "file-number": "333-73470", "film-number": "1793447"}, "business-address": {"street1": "6304 SPINE RD", "street2": "UNIT A", "city": "BOULDER", "state": "CO", "zip": "80301", "phone": "3035303891"}, "mail-address": {"street1": "6304 SPINE RD", "street2": "UNIT A", "city": "BOULDER", "state": "CO", "zip": "80301"}}
Form S-8, 11/13/01
As filed with the Securities and Exchange Commission on November 15, 2001
Registration No. 333-
SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM S-8
REGISTRATION STATEMENT
UNDER
THE SECURITIES ACT OF 1933
NaPro BioTherapeutics, Inc.
(Exact name of registrant as specified in its charter)
Delaware
84-1187753
(State of Incorporation)
(I.R.S. Employer Identification No.)
6304 Spine Road, Unit A
Boulder, Colorado 80301
Telephone: (303) 530-3891
(Address of principal executive offices)
NaPro BioTherapeutics, Inc.
1994 Long-Term Performance Incentive Plan
1998 Stock Incentive Plan
of NaPro BioTherapeutics, Inc.
(Full title of the plans)
Gordon H. Link, Jr.
Chief Financial Officer
6304 Spine Road, Unit A
Boulder, Colorado 80301
Telephone: (303) 530-3891
Telecopier: (303) 530-1296
(Name, address, including zip code, and telephone number, including area code, of agent for service)
Copies to:
Francis R. Wheeler, Esq.
Cooley Godward LLP
380 Interlocken Crescent, Suite 900
Broomfield, Colorado 80021-8023
Telephone: (720) 566-4000
Telecopier: (720) 566-4099
CALCULATION OF REGISTRATION FEE
Title of Securities
to be Registered
Amount to be Registered
Proposed Maximum
Offering
Price per Share (1)
Proposed Maximum
Aggregate
Offering Price (1)
Amount of
Registration Fee
Common Stock and Stock Options
(par value $.0075)
1,825,000 shares
$9.07
$16,560,627.43
$4,140.16
Estimated solely for the purpose of calculating the amount of the registration fee pursuant to Rules 457(c) and (h)(1) under the Securities Act of 1933, as amended (the "Securities Act"). The price per share and aggregate offering price are based upon (i) the weighted average exercise price of options outstanding and (ii) the average of the high and low prices of the Registrant's Common Stock on November 8, 2001 as reported on Nasdaq National Market. The following chart illustrates our calculation of the registration fee:
Type of Shares
Number of Shares
Offering Price Per Share
Aggregate Offering Price
Shares issuable pursuant to options outstanding under the 1994 Long-Term Performance Incentive Plan
785,791
$9.49(a)
$7,457,156.59
Shares issuable under the 1994 Long-Term Performance Incentive Plan
539,209
$8.76(b)
$4,723,470.84
Shares issuable under the 1998 Stock Incentive Plan
500,000
$8.76(b)
$4,380,000.00
Based on the weighted average exercise price of options outstanding.
Based on the average of the high and low prices of the Registrant's Common Stock on November 8, 2001 as reported on Nasdaq National Market.
INCORPORATION BY REFERENCE
The following documents filed by NaPro Biotherapeutics, Inc. a Delaware corporation (the "Company" or the "Registrant"), with the Securities and Exchange Commission (the "Commission") are incorporated by reference into this Registration Statement:
The Registration Statement on Form S-8 No. 333-52008, filed December 15, 2000;
The Company's latest annual report on Form 10-K for the fiscal year ended December 31, 2000;
The Company's quarterly report on Form 10-Q for the quarter ended March 31, 2001;
The Company's quarterly report on Form 10-Q for the quarter ended June 30, 2001;
The Company's quarterly report on Form 10-Q for the quarter ended September 30, 2001;
A description of the Company's Common Stock, which is contained in the Form 8-A Registration Statement filed on June 13, 1994, as amended;
A description of the Company's preferred stock purchase rights, which is contained in the Form 8-A Registration Statement filed on November 29, 1996, as amended by the Form 8-A12G/A filed on October 23, 2001; and
All reports and other documents subsequently filed by the Company pursuant to Sections 13(a), 13(c), 14, and 15(d) of the Securities Exchange Act of 1934, as amended (the "Exchange Act"), prior to the filing of a post effective amendment which indicates that all securities offered have been sold or which deregisters all securities then remaining unsold, shall be deemed to be incorporated by reference herein and to be a part of this registration statement from the date of the filing of such reports and documents.
EXHIBITS
Exhibit
Number
5
Opinion of Cooley Godward LLP
23.1
Consent of Ernst & Young LLP
23.2
Consent of Cooley Godward LLP is contained in Exhibit 5 to this Registration Statement
24
Power of Attorney is contained on the signature pages.
SIGNATURES
Pursuant to the requirements of the Securities Act of 1933, as amended, the Registrant certifies that it has reasonable grounds to believe that it meets all of the requirements for filing on Form S-8 and has duly caused this Registration Statement to be signed on its behalf by the undersigned, thereunto duly authorized, in the City of Boulder, State of Colorado, on November 13, 2001.
NaPro BioTherapeutics, Inc.
By: s/ Kai Larson
Title: Vice President, General Counsel
POWER OF ATTORNEY
Know All Persons By These Presents
, that each person whose signature appears below constitutes and appoints Gordon H. Link, Jr. and Robert L. Poley, and each or any one of them, his true and lawful attorney-in-fact and agent, with full power of substitution and resubstitution, for him and in his name, place and stead, in any and all capacities, to sign any and all amendments (including post-effective amendments) to this Registration Statement, and to file the same, with all exhibits thereto, and other documents in connection therewith, with the Securities and Exchange Commission, granting unto said attorneys-in-fact and agents, and each of them, full power and authority to do and perform each and every act and thing requisite and necessary to be done in connection therewith, as fully to all intents and purposes as he might or could do in person, hereby ratifying and confirming all that said attorneys-in-fact and agents, or any of them, or their or his substitutes or substitute, may lawfully do or cause to be done by virtue hereof.
Pursuant to the requirements of the Securities Act of 1933, this Registration Statement has been signed by the following persons in the capacities and on the dates indicated.
Signature
Title
Date
/s/
(Leonard P. Shaykin)
Chairman of the Board
Chief Executive Officer
November 12, 2001
/s/
(Sterling Ainsworth)
Vice Chairman
President
Chief Scientific Officer
Director
November 12, 2001
/s/
(Patricia A. Pilia, Ph.D.)
Executive Vice President
Director
November 12, 2001
/s/
(Gordon H. Link, Jr.)
Vice President
Chief Financial Officer
(Principal Financial Officer)
November 12, 2001
/s/
(Robert L. Poley)
Controller
(Principal Accounting Officer)
November 13, 2001
/s/
(Edward L. Erickson)
Director
November 13, 2001
/s/
(Arthur H. Hayes, Jr., M.D.)
Director
November 13, 2001
/s/
(Marc J. Ostro, Ph.D.
Director
November 12, 2001
/s/
(The Honorable Richard N. Perle)
Director
November 9, 2001
/s/
(Robert E. Pollack, Ph.D.)
Director
November 12, 2001
EXHIBIT INDEX
Exhibit
Number
Sequential Page Numbers
5
Opinion of Cooley Godward LLP
23.1
Consent of Ernst & Young LLP
23.2
Consent of Cooley Godward LLP is contained in Exhibit 5 to this Registration Statement
24
Power of Attorney is contained on the signature pages.