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<p style=' margin-bottom:0pt; margin-top:0pt;text-align:center;'><B><font SIZE=3>UNITED STATES</font></B></p>

<p style=' margin-bottom:0pt; margin-top:0pt;text-align:center;'><B><font SIZE=3>SECURITIES AND EXCHANGE COMMISSION</font></B></p>

<p style=' margin-bottom:0pt; margin-top:0pt;text-align:center;'><B><font SIZE=2>WASHINGTON, D.C. 20549</font></B></p>

<p style=' margin-bottom:0pt; margin-top:0pt;text-align:center;'><font size=3>&nbsp;</font></p>

<p style=' margin-bottom:0pt; margin-top:0pt;text-align:center;'><B><font SIZE=3>FORM S-8</font></B></p>

<p style=' margin-bottom:0pt; margin-top:0pt;text-align:center;'><font size=2>&nbsp;</font></p>

<p style=' margin-bottom:0pt; margin-top:0pt;text-align:center;'><B><font SIZE=2>REGISTRATION STATEMENT</font></B><font size=2> </font><B><font SIZE=2>UNDER THE</font></B></p>

<p style=' margin-bottom:0pt; margin-top:0pt;text-align:center;'><B><font SIZE=2>SECURITIES ACT OF 1933</font></B></p>

<p style=' margin-bottom:0pt; margin-top:0pt;text-align:center;'><font size=3>&nbsp;</font></p>

<p style=' margin-bottom:0pt; margin-top:0pt;text-align:center;'><B><font SIZE=3>ADVANCED MAGNETICS, INC.</font></B></p>

<p style=' margin-bottom:0pt; margin-top:0pt;text-align:center;'><font size=2>(Exact name of registrant as specified in its charter)</font></p>

<p style=' margin-bottom:0pt; margin-top:0pt;text-align:center;'><font size=2>&nbsp;</font></p>


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            <p style='margin-left:0pt;text-indent:0pt;text-align:center;margin-top:0pt;margin-bottom:0pt'><b><font size=2>Delaware</font></b></p>
<p style='margin-left:0pt;text-indent:0pt;text-align:center;margin-top:0pt;margin-bottom:0pt'><font size=2>(State or Other Jurisdiction of </font></p>
<p style='margin-left:0pt;text-indent:0pt;text-align:center;margin-top:0pt;margin-bottom:0pt'><font size=2>Incorporation or Organization)</font></p> </td>
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            <p style='margin-left:0pt;text-indent:0pt;text-align:center;margin-top:0pt;margin-bottom:0pt'><b><font size=2>04-2742593</font></b></p>
<p style='margin-left:0pt;text-indent:0pt;text-align:center;margin-top:0pt;margin-bottom:0pt'><font size=2>(I.R.S. Employer </font></p>
<p style='margin-left:0pt;text-indent:0pt;text-align:center;margin-top:0pt;margin-bottom:0pt'><font size=2>Identification No.)</font></p> </td> </tr></table>

<p style=' margin-bottom:0pt; margin-top:0pt;text-align:center;'><font size=2>&nbsp;</font></p>

<p style=' margin-bottom:0pt; margin-top:0pt;text-align:center;'><b><font size=2>61 Mooney Street Cambridge, Massachusetts 02138</font></b></p>

<p style=' margin-bottom:0pt; margin-top:0pt;text-align:center;'><font size=2>(Address of Principal Executive Offices including zip code)</font></p>

<p style=' margin-bottom:0pt; margin-top:0pt;text-align:justify;'><font size=2>&nbsp;</font></p>

<p style=' margin-bottom:0pt; margin-top:0pt;text-align:center;'><b><font size=2>Advanced Magnetics, Inc. Amended and Restated 2000 Stock Plan</font></b></p>

<p style=' margin-bottom:0pt; margin-top:0pt;text-align:center;'><font size=2>(Full Title of the Plan)</font></p>

<p style=' margin-bottom:0pt; margin-top:0pt;text-align:center;'><font size=2>&nbsp;</font></p>


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            <p style='margin-left:0pt;text-indent:0pt;text-align:center;margin-top:0pt;margin-bottom:0pt'><font size=2>Jerome Goldstein</font></p>
<p style='margin-left:0pt;text-indent:0pt;text-align:center;margin-top:0pt;margin-bottom:0pt'><font size=2>Chief Executive Officer</font></p>
<p style='margin-left:0pt;text-indent:0pt;text-align:center;margin-top:0pt;margin-bottom:0pt'><font size=2>Advanced Magnetics, Inc.</font></p>
<p style='margin-left:0pt;text-indent:0pt;text-align:center;margin-top:0pt;margin-bottom:0pt'><font size=2>61 Mooney Street</font></p>
<p style='margin-left:0pt;text-indent:0pt;text-align:center;margin-top:0pt;margin-bottom:0pt'><font size=2>Cambridge, Massachusetts 02138</font></p>
<p style='margin-left:0pt;text-indent:0pt;text-align:center;margin-top:0pt;margin-bottom:0pt'><font size=2>(617) 497-2070</font></p> </td>
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            <p style='margin-left:0pt;text-indent:0pt;text-align:center;margin-top:0pt;margin-bottom:0pt'><B><font SIZE=2>COPY TO:</font></B></p>
<p style='margin-left:0pt;text-indent:0pt;text-align:center;margin-top:0pt;margin-bottom:0pt'><font size=2>Miguel J. Vega, Esq.</font></p>
<p style='margin-left:0pt;text-indent:0pt;text-align:center;margin-top:0pt;margin-bottom:0pt'><font size=2>Sullivan &amp; Worcester LLP</font></p>
<p style='margin-left:0pt;text-indent:0pt;text-align:center;margin-top:0pt;margin-bottom:0pt'><font size=2>One Post Office Square</font></p>
<p style='margin-left:0pt;text-indent:0pt;text-align:center;margin-top:0pt;margin-bottom:0pt'><font size=2>Boston, Massachusetts 02109</font></p>
<p style='margin-left:0pt;text-indent:0pt;text-align:center;margin-top:0pt;margin-bottom:0pt'><font size=2>(617) 338-2800</font></p>
<p style='margin-left:0pt;text-indent:0pt;text-align:center;margin-top:0pt;margin-bottom:0pt'><font size=1>&nbsp;</font></p> </td> </tr></table>

<p style=' margin-bottom:0pt; margin-top:0pt;text-align:center;'><font size=2>(Name, Address and Telephone Number of Agent For Service)</font></p>

<p style=' margin-bottom:0pt; margin-top:0pt;text-align:center;'><font size=2>&nbsp;</font></p>

<p style=' margin-bottom:0pt; margin-top:0pt; text-indent:7.6%;text-align:justify;'><font size=2>If, as a result of stock splits, stock dividends or similar transactions, the number of securities purported to be registered on this registration statement changes, the provisions of Rule 416 under the Securities Act of 1933, as amended, shall apply to this registration statement. </font></p>

<p style=' margin-bottom:0pt; margin-top:0pt;text-align:justify;'><font size=2>&nbsp;</font></p>

<p style=' margin-bottom:0pt; margin-top:0pt; text-indent:7.6%;text-align:justify;'><font size=2>The prospectus meeting the requirements of Section 10(a) of the Securities Act of 1933, as amended, which is being provided to participants in the Advanced Magnetics, Inc. Amended and Restated 2000 Stock Plan in conjunction with this registration statement also relates to the shares registered under the Registration Statement on Form S-8 dated February 6, 2002 (File No. 333-82292) of Advanced Magnetics, Inc.</font></p>

<p style=' margin-bottom:0pt; margin-top:0pt;text-align:justify;'><font size=2>&nbsp;</font></p>

<p style=' margin-bottom:12pt; margin-top:0pt;text-align:center;'><B><font SIZE=2>CALCULATION OF REGISTRATION FEE</font></B></p>


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            <p style='margin-left:0pt;text-indent:0pt;text-align:center;margin-top:0pt;margin-bottom:0pt'><font size=1>&nbsp;</font></p>
<p style='margin-left:0pt;text-indent:0pt;text-align:center;margin-top:0pt;margin-bottom:0pt'><b><font size=1>Title of Each Class of Securities to be Registered</font></b></p> </td>
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            <p style='margin-left:0pt;text-indent:0pt;text-align:center;margin-top:0pt;margin-bottom:0pt'><font size=1>&nbsp;</font></p>
<p style='margin-left:0pt;text-indent:0pt;text-align:center;margin-top:0pt;margin-bottom:0pt'><b><font size=1>Amount to be Registered(1)</font></b></p> </td>
        <td width="114" valign=top style='padding:0in 5.4pt 0in 5.4pt'>
            <p style='margin-left:0pt;text-indent:0pt;text-align:center;margin-top:0pt;margin-bottom:0pt'><b><font size=1>Proposed Maximum Offering Price Per Unit(2)</font></b></p> </td>
        <td width="119" valign=top style='padding:0in 5.4pt 0in 5.4pt'>
            <p style='margin-left:0pt;text-indent:0pt;text-align:center;margin-top:0pt;margin-bottom:0pt'><b><font size=1>Proposed Maximum Aggregate Offering Price</font></b></p> </td>
        <td width="128" valign=top style='padding:0in 5.4pt 0in 5.4pt'>
            <p style='margin-left:0pt;text-indent:0pt;text-align:center;margin-top:0pt;margin-bottom:0pt'><font size=1>&nbsp;</font></p>
<p style='margin-left:0pt;text-indent:0pt;text-align:center;margin-top:0pt;margin-bottom:0pt'><b><font size=1>Amount of Registration Fee</font></b></p> </td> </tr>
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            <p style='margin-left:0pt;text-indent:0pt;text-align:left;margin-top:0pt;margin-bottom:0pt'>
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            <p style='margin-left:0pt;text-indent:0pt;text-align:left;margin-top:0pt;margin-bottom:0pt'>
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            <p style='margin-left:0pt;text-indent:0pt;text-align:left;margin-top:0pt;margin-bottom:0pt'>
<HR noshade width="100%"  color="gray" size="1"> </td>
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            <p style='margin-left:0pt;text-indent:0pt;text-align:left;margin-top:0pt;margin-bottom:0pt'>
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            <p style='margin-left:0pt;text-indent:0pt;text-align:left;margin-top:0pt;margin-bottom:0pt'><font size=1>Common Stock, $0.01 par value per share</font></p> </td>
        <td width="108" valign=top style='padding:0in 5.4pt 0in 5.4pt'>
            <p style='margin-left:0pt;text-indent:0pt;text-align:center;margin-top:0pt;margin-bottom:0pt'><font size=1>1,000,000</font></p> </td>
        <td width="114" valign=top style='padding:0in 5.4pt 0in 5.4pt'>
            <p style='margin-left:0pt;text-indent:0pt;text-align:center;margin-top:0pt;margin-bottom:0pt'><font size=1>$20.13</font></p> </td>
        <td width="119" valign=top style='padding:0in 5.4pt 0in 5.4pt'>
            <p style='margin-left:0pt;text-indent:0pt;text-align:center;margin-top:0pt;margin-bottom:0pt'><font size=1>$20,130,000</font></p> </td>
        <td width="128" valign=top style='padding:0in 5.4pt 0in 5.4pt'>
            <p style='margin-left:0pt;text-indent:0pt;text-align:center;margin-top:0pt;margin-bottom:0pt'><font size=1>$2,154</font></p> </td> </tr>
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            <p style='margin-left:0pt;text-indent:0pt;text-align:left;margin-top:0pt;margin-bottom:0pt'>
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            <p style='margin-left:0pt;text-indent:0pt;text-align:left;margin-top:0pt;margin-bottom:0pt'>
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            <p style='margin-left:0pt;text-indent:0pt;text-align:left;margin-top:0pt;margin-bottom:0pt'>
<HR noshade width="100%"  color="gray" size="1"> </td> </tr></table>

<p style=' margin-bottom:0pt; margin-top:0pt;text-align:justify;'><font size=1>&nbsp;</font></p>

<p style=' margin-bottom:0pt; margin-top:0pt;text-align:left;'><font size=1>(1) The maximum number of
shares which may be sold upon the exercise of
options granted under the Advanced Magnetics, Inc. Amended and Restated 2000
Stock Plan is subject to adjustment in accordance with certain structural
anti-dilution and other provisions of the Advanced Magnetics, Inc. Amended
and Restated 2000 Stock Plan. Accordingly, pursuant to Rule 416 under the Securities Act of 1933, as amended, this registration statement covers, in addition to the number of shares stated above, an indeterminate </font></p>


<p style=' margin-bottom:0pt; margin-top:0pt;text-align:left;'><font size=2>&nbsp;</font></p>
<br>
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<p style=' margin-bottom:0pt; margin-top:0pt;text-align:left;'>
<font size=1>number of shares which may be subject to grant or otherwise issuable after the operation of any such structural anti-dilution and other provisions.</font></p>

<p style=' margin-bottom:0pt; margin-top:0pt;text-align:justify;'><font size=1>&nbsp;</font></p>

<p style=' margin-bottom:0pt; margin-top:0pt;text-align:justify;'><font size=1>(2) The proposed maximum offering price per share and the proposed maximum aggregate offering price have been estimated solely for the purpose of calculating the amount of the registration fee in accordance with Rules 457(c) and 457(h) under the Securities Act of 1933 on the basis of the average of the high and low prices of the Common Stock on the American Stock Exchange on February 3, 2006.</font></p>

<p style=' margin-bottom:0pt; margin-top:0pt;text-align:justify;'><font size=2>&nbsp;</font></p>

<p style=' margin-bottom:5pt; margin-top:5pt;text-align:center;'><b><font size=2>Registration of Additional Securities &#150; Explanatory Note</font></b></p>

<p style=' margin-bottom:0pt; margin-top:0pt; text-indent:4.53%;text-align:left;'><font size=2>We are filing this registration statement to register an additional 1,000,000 shares of our common stock for issuance under the Advanced Magnetics, Inc. Amended and Restated 2000 Stock Plan (the &#147;Plan&#148;).  The increase in the number of shares authorized for issuance under the Plan was approved by our stockholders at our 2006 annual meeting held on February 7, 2006.  On February 6, 2002 we filed a registration statement on Form S-8 (Reg. No. 333-82292) covering 1,000,000 shares of our common stock authorized for issuance under the original version of the Plan (the &#147;Prior Registration Statement&#148;) with the Securities and Exchange Commission (the &#147;Commission&#148;).&nbsp;&nbsp;Pursuant to General Instruction E to Form S-8, the contents of the Prior Registration Statement are incorporated herein by reference, except for Item 3 and Item 8 of the Prior Registration
Statement, which is being updated by this registration statement. </font><font size=1>&nbsp;</font></p>

<p style=' margin-bottom:0pt; margin-top:0pt;text-align:left;'><font size=2>&nbsp;</font></p>

<p style=' margin-bottom:12pt; margin-top:0pt;text-align:center;'><B><font SIZE=2>PART II - INFORMATION REQUIRED IN THE REGISTRATION STATEMENT</font></B></p>

<p style=' margin-bottom:12pt; margin-top:0pt;text-align:left;'><b><font size=2>Item 3. Incorporation of Documents by Reference.</font></b></p>

<p style=' margin-bottom:12pt; margin-top:0pt; text-indent:6.67%;text-align:justify;'><font size=2>The following additional documents, which have been filed by the Company with the Commission, are incorporated by reference in and made a part of this registration statement, as of their respective dates:</font></p>


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            <p style='margin-left:0pt;text-indent:0pt;text-align:left;margin-top:0pt;margin-bottom:12.0pt'><font size=1>&nbsp;</font></p> </td>
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            <p style='margin-left:0pt;text-indent:0pt;text-align:left;margin-top:0pt;margin-bottom:0pt'><font size=2>(a)</font></p> </td>
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            <p style='margin-left:0pt;text-indent:0pt;text-align:left;margin-top:0pt;margin-bottom:0pt'><font size=2>The Company&#146;s Annual Report on Form 10-K for the fiscal year ended September 30, 2005 filed on December 14, 2005;</font></p> </td> </tr></table>



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            <p style='margin-left:0pt;text-indent:0pt;text-align:left;margin-top:0pt;margin-bottom:12.0pt'><font size=1>&nbsp;</font></p> </td>
        <td width="6%" valign=top style='padding:0in 0in 12.0pt 0in'>
            <p style='margin-left:0pt;text-indent:0pt;text-align:left;margin-top:0pt;margin-bottom:0pt'><font size=2>(b)</font></p> </td>
        <td  valign=top style='padding:0in 0in 12.0pt 0in'>
            <p style='margin-left:0pt;text-indent:0pt;text-align:left;margin-top:0pt;margin-bottom:0pt'><font size=2>The Company&#146;s Current Report on Form 8-K filed January 19, 2006; and</font></p> </td> </tr></table>



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            <p style='margin-left:0pt;text-indent:0pt;text-align:justify;margin-top:0pt;margin-bottom:12pt'><font size=1>&nbsp;</font></p>  </td>
        <td width="6%" valign=top style='padding:0in 0in 12.0pt 0in'>
            <p style='margin-left:0pt;text-indent:0pt;text-align:left;margin-top:0pt;margin-bottom:0pt'><font size=2>(c)</font></p> </td>
        <td  valign=top style='padding:0in 0in 12.0pt 0in'>
            <p style='margin-left:0pt;text-indent:0pt;text-align:justify;margin-top:0pt;margin-bottom:0pt'><font size=2>The description of the Company&#146;s common stock contained in the registration statement on Form 8-A dated September 24, 1991 (File No. 0-14732), including all amendments or reports filed for the purpose of updating such description.</font></p> </td> </tr></table>


<p style=' margin-bottom:12pt; margin-top:0pt; text-indent:6.67%;text-align:justify;'><font size=2>All documents subsequently filed by the Company pursuant to Sections 13(a), 13(c), 14 and 15(d) of the Securities Exchange Act of 1934, as amended, prior to the filing of a post-effective amendment which indicates that all securities offered have been sold or which deregisters all securities then remaining unsold, shall be deemed to be incorporated by reference in this registration statement and to be part hereof from the date of filing of such documents.</font></p>

<p style=' margin-bottom:12pt; margin-top:0pt; text-indent:6.67%;text-align:justify;'><font size=2>Any statement contained in a document incorporated or deemed to be incorporated by reference herein shall be deemed to be modified or superseded for purposes of this registration statement to the extent that a statement herein, or in any subsequently filed document which also is or is deemed to be incorporated by reference, modifies or supersedes such statement.  Any statement so modified or superseded shall not be deemed, except as so modified or superseded, to constitute a part of this registration statement.</font></p>


<p style=' margin-bottom:0pt; margin-top:0pt;text-align:left;'><font size=2>&nbsp;</font></p>
<br>
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<p style=' margin-bottom:12pt; margin-top:0pt;text-align:left;'>
<b><font size=2>Item 8. Exhibits.</font></b></p>

<p style=' margin-bottom:12pt; margin-top:0pt;text-align:center;'><B><font SIZE=2>EXHIBIT INDEX</font></B></p>


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            <p  style='text-indent:0in'><B><font SIZE=2>EXHIBIT NO.</font></B></p> </td>
        <td width="82%" valign=top style='padding:0in 5.4pt 0in 5.4pt'>
            <p  style='text-indent:0in'><B><font SIZE=2>DESCRIPTION</font></B></p> </td> </tr>
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            <p  style='text-indent:0in'><font size=2>5.1</font></p> </td>
        <td width="82%" valign=top style='padding:0in 5.4pt 0in 5.4pt'>
            <p  style='text-indent:0in'><font size=2>Opinion of Sullivan &amp; Worcester LLP.*</font></p> </td> </tr>
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        <td width="17%" valign=top style='padding:0in 5.4pt 0in 5.4pt'>
            <p  style='text-indent:0in'><font size=2>23.1</font></p> </td>
        <td width="82%" valign=top style='padding:0in 5.4pt 0in 5.4pt'>
            <p  style='text-indent:0in'><font size=2>Consent of Sullivan &amp; Worcester LLP (contained in the opinion of Sullivan &amp; Worcester LLP filed herewith as Exhibit 5.1).</font></p> </td> </tr>
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            <p  style='text-indent:0in'><font size=2>23.3</font></p> </td>
        <td width="82%" valign=top style='padding:0in 5.4pt 0in 5.4pt'>
            <p  style='text-indent:0in'><font size=2>Consent of Independent Registered Public Accounting Firm &#150; PricewaterhouseCoopers LLP.*</font></p> </td> </tr>
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        <td width="17%" valign=top style='padding:0in 5.4pt 0in 5.4pt'>
            <p  style='text-indent:0in'><font size=2>24</font></p> </td>
        <td width="82%" valign=top style='padding:0in 5.4pt 0in 5.4pt'>
            <p  style='text-indent:0in'><font size=2>Powers of Attorney (included in the signature page to this registration statement).</font></p> </td> </tr></table>

<p style=' margin-bottom:0pt; margin-top:0pt; margin-left:13.33%; text-indent:-6.67%;text-align:left;'><font size=2>&nbsp;</font></p>

<p style=' margin-bottom:12pt; margin-top:0pt;text-align:left;'><font size=2>___________</font></p>


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        <td width="10%" nowrap valign=top style='padding:0in 0in 12.0pt 0in; '>
            <p style='margin-left:0pt;text-indent:0pt;text-align:left;margin-top:0pt;margin-bottom:0pt'><font size=2>*</font></p> </td>
        <td width="90%" nowrap valign=top style='padding:0in 0in 12.0pt 0in; '>
            <p style='margin-left:0pt;text-indent:0pt;text-align:left;margin-top:0pt;margin-bottom:0pt'><font size=2>filed herewith</font></p> </td> </tr></table>


<p style=' margin-bottom:0pt; margin-top:0pt;text-align:left;'><font size=2>&nbsp;</font></p>
<br>
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<PAGE>


<p style=' margin-bottom:12pt; margin-top:0pt;text-align:center;'>
<B><font SIZE=2>SIGNATURES</font></B></p>

<p style=' margin-bottom:12pt; margin-top:0pt; text-indent:6.67%;text-align:justify;'><font size=2>Pursuant to the requirements of the Securities Act of 1933, the Company certifies that it has reasonable grounds to believe that it meets all of the requirements for filing on Form S-8 and has duly caused this registration statement to be signed on its behalf by the undersigned, thereunto duly authorized, in the City of Cambridge, Commonwealth of Massachusetts, on the 7<sup>th</sup> day of February, 2006.</font></p>


<table width="600" border="0" cellspacing=0 cellpadding=0 style='margin-left:3.2in; border-collapse:collapse'>
    <tr>
        <td width="100%" valign=top style='padding:0in 5.4pt 0in 5.4pt'>
            <p style='margin-left:0pt;text-indent:0pt;text-align:left;margin-top:0pt;margin-bottom:0pt'><B><font SIZE=2>ADVANCED MAGNETICS, INC. </font></B></p> </td> </tr>
    <tr>
        <td width="100%" valign=top style='padding:0in 5.4pt 0in 5.4pt'>
            <p style='margin-left:0pt;text-indent:0pt;text-align:left;margin-top:0pt;margin-bottom:0pt'><font size=1>&nbsp;</font></p> </td> </tr>
    <tr>
        <td width="100%" valign=top style='padding:0in 5.4pt 0in 5.4pt'>
            <p style='margin-left:0pt;text-indent:0pt;text-align:left;margin-top:0pt;margin-bottom:0pt'><font size=1>&nbsp;</font></p> </td> </tr>
    <tr>
        <td width="100%" valign=top style='padding:0in 5.4pt 0in 5.4pt'>
            <p style='margin-left:0pt;text-indent:0pt;text-align:left;margin-top:0pt;margin-bottom:0pt'><font size=2>By:  </font><u><font size=2>/s/ Jerome Goldstein</font></u></p> </td> </tr>
    <tr>
        <td width="100%" valign=top style='padding:0in 5.4pt 0in 5.4pt'>
            <p style='margin-left:0pt;text-indent:0pt;text-align:left;margin-top:0pt;margin-bottom:0pt'><font size=2>Name:&nbsp;Jerome Goldstein</font><br> <font size=2>Title:&nbsp;&nbsp;&nbsp;Chairman of the Board and Chief Executive Officer </font></p> </td> </tr>
    <tr>
        <td width="100%" valign=top style='padding:0in 5.4pt 0in 5.4pt'>
            <p style='margin-left:0pt;text-indent:0pt;text-align:left;margin-top:0pt;margin-bottom:0pt'><font size=1>&nbsp;</font></p> </td> </tr></table>

<p style=' margin-bottom:0pt; margin-top:0pt;text-align:left;'><font size=2>&nbsp;</font></p>

<p style=' margin-bottom:12pt; margin-top:0pt; text-indent:6.67%;text-align:justify;'><font size=2>Pursuant to the requirements of the Securities Act of 1933, this registration statement on Form S-8 has been signed below by the following persons in the capacities and on the dates indicated.  The undersigned officers and directors of the Company hereby severally constitute and appoint Jerome Goldstein and Joseph L. Farmer, and each of them acting singly, our true and lawful attorneys to sign for us and in our names in the capacities indicated below any and all amendments or supplements, whether pre-effective or post-effective, to this registration statement on Form S-8 and to file the same, with exhibits thereto and other documents in connection therewith, with the Commission, granting unto each of said attorneys, acting singly, full power and authority to do and perform each and every act and thing requisite or necessary to be done in and about the premises, as fully to all intents
and purposes as he or she might or could do in person, hereby ratifying and confirming our signatures to said amendments to this registration statement signed by our said attorneys and all else that said attorneys may lawfully do and cause to be done by virtue hereof. </font></p>


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    <tr>
        <td width="213" valign=top style='padding:0in 5.4pt 0in 5.4pt'>
            <p  align=center style='text-align:center;text-indent:0in'><u><b><font size=2>Signature</font></b></u><u></u></p> </td>
        <td width="238" valign=top style='padding:0in 5.4pt 0in 5.4pt'>
            <p  align=center style='text-align:center;text-indent:0in'><u><b><font size=2>Title</font></b></u><u></u></p> </td>
        <td width="187" valign=top style='padding:0in 5.4pt 0in 5.4pt'>
            <p  align=center style='text-align:center;text-indent:0in'><u><b><font size=2>Date</font></b></u><u></u></p> </td> </tr>
    <TR>
      <TD> &nbsp;</TD>
      <TD> </TD>
      <TD> </TD></TR>
<tr>
        <td width="213" valign=top style='padding:0in 5.4pt 0in 5.4pt'>
            <p  style='margin-bottom:0.0pt;text-indent:0in'><u><font size=2>/s/ Jerome Goldstein</font></u><br> <font size=2>Jerome Goldstein</font></p> </td>
        <td width="238" valign=top style='padding:0in 5.4pt 0in 5.4pt'>
            <p  style='text-indent:0in'><font size=2>Chairman of the Board of Directors and Chief Executive Officer </font></p> </td>
        <td width="187" valign=top style='padding:0in 5.4pt 0in 5.4pt'>
            <p  align=center style='text-align:center;text-indent:0in'><font size=2>February  7, 2006</font></p> </td> </tr>
<TR>
      <TD> &nbsp;</TD>
      <TD> </TD>
      <TD> </TD></TR>
    <tr>
        <td width="213" valign=top style='padding:0in 5.4pt 0in 5.4pt'>
            <p  style='margin-bottom:0.0pt;text-indent:0in'><u><font size=2>/s/ Brian J.G. Pereira</font></u><br> <font size=2>Brian J.G. Pereira</font></p> </td>
        <td width="238" valign=top style='padding:0in 5.4pt 0in 5.4pt'>
            <p  style='text-indent:0in'><font size=2>President and Director</font></p> </td>
        <td width="187" valign=top style='padding:0in 5.4pt 0in 5.4pt'>
            <p  align=center style='text-align:center;text-indent:0in'><font size=2>February 7, 2006</font></p> </td> </tr>
<TR>
      <TD> &nbsp;</TD>
      <TD> </TD>
      <TD> </TD></TR>
    <tr>
        <td width="213" valign=top style='padding:0in 5.4pt 0in 5.4pt'>
            <p  style='margin-bottom:0.0pt;text-indent:0in'><u><font size=2>/s/ Michael N. Avallone</font></u><br> <font size=2>Michael N. Avallone</font></p> </td>
        <td width="238" valign=top style='padding:0in 5.4pt 0in 5.4pt'>
            <p  style='text-indent:0in'><font size=2>Chief Financial Officer</font></p> </td>
        <td width="187" valign=top style='padding:0in 5.4pt 0in 5.4pt'>
            <p  align=center style='text-align:center;text-indent:0in'><font size=2>February 7, 2006</font></p> </td> </tr>
<TR>
      <TD> &nbsp;</TD>
      <TD> </TD>
      <TD> </TD></TR>
    <tr>
        <td width="213" valign=top style='padding:0in 5.4pt 0in 5.4pt'>
            <p  style='margin-bottom:0.0pt;text-indent:0in'><u><font size=2>/s/Sheldon Bloch</font></u><br> <font size=2>Sheldon Bloch</font></p> </td>
        <td width="238" valign=top style='padding:0in 5.4pt 0in 5.4pt'>
            <p  style='margin-bottom:0in; text-indent:0in'><font size=2>Director</font></p> </td>
        <td width="187" valign=top style='padding:0in 5.4pt 0in 5.4pt'>
            <p  align=center style='text-align:center;text-indent:0in'><font size=2>February 7, 2006</font></p> </td> </tr>
<TR>
      <TD> &nbsp;</TD>
      <TD> </TD>
      <TD> </TD></TR>
    <tr>
        <td width="213" valign=top style='padding:0in 5.4pt 0in 5.4pt'>
            <p  style='margin-bottom:0.0pt;text-indent:0in'><u><font size=2>/s/ Michael D. Loberg </font></u><br> <font size=2>Dr. Michael D. Loberg </font></p> </td>
        <td width="238" valign=top style='padding:0in 5.4pt 0in 5.4pt'>
            <p  style='text-indent:0in'><font size=2>Director</font></p> </td>
        <td width="187" valign=top style='padding:0in 5.4pt 0in 5.4pt'>
            <p  align=center style='text-align:center;text-indent:0in'><font size=2>February 7, 2006</font></p> </td> </tr>
<TR>
      <TD> &nbsp;</TD>
      <TD> </TD>
      <TD> </TD></TR>
    <tr>
        <td width="213" valign=top style='padding:0in 5.4pt 0in 5.4pt'>
            <p  style='margin-bottom:0.0pt;text-indent:0in'><u><font size=2>/s/ Edward B. Roberts</font></u><br> <font size=2>Dr. Edward B. Roberts</font></p> </td>
        <td width="238" valign=top style='padding:0in 5.4pt 0in 5.4pt'>
            <p  style='text-indent:0in'><font size=2>Director</font></p> </td>
        <td width="187" valign=top style='padding:0in 5.4pt 0in 5.4pt'>
            <p  align=center style='text-align:center;text-indent:0in'><font size=2>February 7, 2006</font></p> </td> </tr>
<TR>
      <TD> &nbsp;</TD>
      <TD> </TD>
      <TD> </TD></TR>
    <tr>
        <td width="213" valign=top style='padding:0in 5.4pt 0in 5.4pt'>
            <p  style='margin-bottom:0.0pt;text-indent:0in'><u><font size=2>/s/ Mark Skaletsky</font></u><br> <font size=2>Mark Skaletsky</font></p> </td>
        <td width="238" valign=top style='padding:0in 5.4pt 0in 5.4pt'>
            <p  style='text-indent:0in'><font size=2>Director</font></p> </td>
        <td width="187" valign=top style='padding:0in 5.4pt 0in 5.4pt'>
            <p  align=center style='text-align:center;text-indent:0in'><font size=2>February 7, 2006</font></p> </td> </tr>
<TR>
      <TD> &nbsp;</TD>
      <TD> </TD>
      <TD> </TD></TR>
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        <td width="213" valign=top style='padding:0in 5.4pt 0in 5.4pt'>
            <p  style='margin-bottom:0.0pt;text-indent:0in'><u><font size=2>/s/ Theodore I. Steinman</font></u><br> <font size=2>Theodore I. Steinman, MD</font></p> </td>
        <td width="238" valign=top style='padding:0in 5.4pt 0in 5.4pt'>
            <p  style='text-indent:0in'><font size=2>Director</font></p> </td>
        <td width="187" valign=top style='padding:0in 5.4pt 0in 5.4pt'>
            <p  align=center style='text-align:center;text-indent:0in'><font size=2>February 7, 2006</font></p> </td> </tr></table>

<p style=' margin-bottom:0pt; margin-top:0pt; margin-left:5.87%;text-align:right;'><font size=2>&nbsp;</font></p>

<p style=' margin-bottom:0pt; margin-top:0pt;text-align:left;'><font size=2>&nbsp;</font></p>

<p style=' margin-bottom:0pt; margin-top:0pt;text-align:left;'><font size=2>&nbsp;</font></p>

<p style=' margin-bottom:0pt; margin-top:0pt;text-align:left;'><font size=2>&nbsp;</font></p>
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{"company-data": {"conformed-name": "ADVANCED MAGNETICS INC", "cik": "0000792977", "assigned-sic": "2835", "irs-number": "042742593", "state-of-incorporation": "DE", "fiscal-year-end": "0930"}, "filing-values": {"form-type": "S-8", "act": "33", "file-number": "333-131656", "film-number": "06587540"}, "business-address": {"street1": "61 MOONEY ST", "city": "CAMBRIDGE", "state": "MA", "zip": "02138", "phone": "6174972070"}, "mail-address": {"street1": "61 MOONEY ST", "city": "CAMBRIDGE", "state": "MA", "zip": "02138"}}
UNITED STATES
SECURITIES AND EXCHANGE COMMISSION
WASHINGTON, D.C. 20549
FORM S-8
REGISTRATION STATEMENT
UNDER THE
SECURITIES ACT OF 1933
ADVANCED MAGNETICS, INC.
(Exact name of registrant as specified in its charter)
Delaware
(State or Other Jurisdiction of
Incorporation or Organization)
04-2742593
(I.R.S. Employer
Identification No.)
61 Mooney Street Cambridge, Massachusetts 02138
(Address of Principal Executive Offices including zip code)
Advanced Magnetics, Inc. Amended and Restated 2000 Stock Plan
(Full Title of the Plan)
Jerome Goldstein
Chief Executive Officer
Advanced Magnetics, Inc.
61 Mooney Street
Cambridge, Massachusetts 02138
(617) 497-2070
COPY TO:
Miguel J. Vega, Esq.
Sullivan & Worcester LLP
One Post Office Square
Boston, Massachusetts 02109
(617) 338-2800
(Name, Address and Telephone Number of Agent For Service)
If, as a result of stock splits, stock dividends or similar transactions, the number of securities purported to be registered on this registration statement changes, the provisions of Rule 416 under the Securities Act of 1933, as amended, shall apply to this registration statement.
The prospectus meeting the requirements of Section 10(a) of the Securities Act of 1933, as amended, which is being provided to participants in the Advanced Magnetics, Inc. Amended and Restated 2000 Stock Plan in conjunction with this registration statement also relates to the shares registered under the Registration Statement on Form S-8 dated February 6, 2002 (File No. 333-82292) of Advanced Magnetics, Inc.
CALCULATION OF REGISTRATION FEE
Title of Each Class of Securities to be Registered
Amount to be Registered(1)
Proposed Maximum Offering Price Per Unit(2)
Proposed Maximum Aggregate Offering Price
Amount of Registration Fee
Common Stock, $0.01 par value per share
1,000,000
$20.13
$20,130,000
$2,154
(1) The maximum number of
shares which may be sold upon the exercise of
options granted under the Advanced Magnetics, Inc. Amended and Restated 2000
Stock Plan is subject to adjustment in accordance with certain structural
anti-dilution and other provisions of the Advanced Magnetics, Inc. Amended
and Restated 2000 Stock Plan. Accordingly, pursuant to Rule 416 under the Securities Act of 1933, as amended, this registration statement covers, in addition to the number of shares stated above, an indeterminate
number of shares which may be subject to grant or otherwise issuable after the operation of any such structural anti-dilution and other provisions.
(2) The proposed maximum offering price per share and the proposed maximum aggregate offering price have been estimated solely for the purpose of calculating the amount of the registration fee in accordance with Rules 457(c) and 457(h) under the Securities Act of 1933 on the basis of the average of the high and low prices of the Common Stock on the American Stock Exchange on February 3, 2006.
Registration of Additional Securities – Explanatory Note
We are filing this registration statement to register an additional 1,000,000 shares of our common stock for issuance under the Advanced Magnetics, Inc. Amended and Restated 2000 Stock Plan (the "Plan").  The increase in the number of shares authorized for issuance under the Plan was approved by our stockholders at our 2006 annual meeting held on February 7, 2006.  On February 6, 2002 we filed a registration statement on Form S-8 (Reg. No. 333-82292) covering 1,000,000 shares of our common stock authorized for issuance under the original version of the Plan (the "Prior Registration Statement") with the Securities and Exchange Commission (the "Commission").  Pursuant to General Instruction E to Form S-8, the contents of the Prior Registration Statement are incorporated herein by reference, except for Item 3 and Item 8 of the Prior Registration
Statement, which is being updated by this registration statement.
PART II - INFORMATION REQUIRED IN THE REGISTRATION STATEMENT
Item 3. Incorporation of Documents by Reference.
The following additional documents, which have been filed by the Company with the Commission, are incorporated by reference in and made a part of this registration statement, as of their respective dates:
(a)
The Company's Annual Report on Form 10-K for the fiscal year ended September 30, 2005 filed on December 14, 2005;
(b)
The Company's Current Report on Form 8-K filed January 19, 2006; and
(c)
The description of the Company's common stock contained in the registration statement on Form 8-A dated September 24, 1991 (File No. 0-14732), including all amendments or reports filed for the purpose of updating such description.
All documents subsequently filed by the Company pursuant to Sections 13(a), 13(c), 14 and 15(d) of the Securities Exchange Act of 1934, as amended, prior to the filing of a post-effective amendment which indicates that all securities offered have been sold or which deregisters all securities then remaining unsold, shall be deemed to be incorporated by reference in this registration statement and to be part hereof from the date of filing of such documents.
Any statement contained in a document incorporated or deemed to be incorporated by reference herein shall be deemed to be modified or superseded for purposes of this registration statement to the extent that a statement herein, or in any subsequently filed document which also is or is deemed to be incorporated by reference, modifies or supersedes such statement.  Any statement so modified or superseded shall not be deemed, except as so modified or superseded, to constitute a part of this registration statement.
Item 8. Exhibits.
EXHIBIT INDEX
EXHIBIT NO.
DESCRIPTION
5.1
Opinion of Sullivan & Worcester LLP.*
23.1
Consent of Sullivan & Worcester LLP (contained in the opinion of Sullivan & Worcester LLP filed herewith as Exhibit 5.1).
23.3
Consent of Independent Registered Public Accounting Firm – PricewaterhouseCoopers LLP.*
24
Powers of Attorney (included in the signature page to this registration statement).
___________
*
filed herewith
SIGNATURES
Pursuant to the requirements of the Securities Act of 1933, the Company certifies that it has reasonable grounds to believe that it meets all of the requirements for filing on Form S-8 and has duly caused this registration statement to be signed on its behalf by the undersigned, thereunto duly authorized, in the City of Cambridge, Commonwealth of Massachusetts, on the 7
th
day of February, 2006.
ADVANCED MAGNETICS, INC.
By:
/s/ Jerome Goldstein
Name: Jerome Goldstein
Title:   Chairman of the Board and Chief Executive Officer
Pursuant to the requirements of the Securities Act of 1933, this registration statement on Form S-8 has been signed below by the following persons in the capacities and on the dates indicated.  The undersigned officers and directors of the Company hereby severally constitute and appoint Jerome Goldstein and Joseph L. Farmer, and each of them acting singly, our true and lawful attorneys to sign for us and in our names in the capacities indicated below any and all amendments or supplements, whether pre-effective or post-effective, to this registration statement on Form S-8 and to file the same, with exhibits thereto and other documents in connection therewith, with the Commission, granting unto each of said attorneys, acting singly, full power and authority to do and perform each and every act and thing requisite or necessary to be done in and about the premises, as fully to all intents
and purposes as he or she might or could do in person, hereby ratifying and confirming our signatures to said amendments to this registration statement signed by our said attorneys and all else that said attorneys may lawfully do and cause to be done by virtue hereof.
Signature
Title
Date
/s/ Jerome Goldstein
Jerome Goldstein
Chairman of the Board of Directors and Chief Executive Officer
February  7, 2006
/s/ Brian J.G. Pereira
Brian J.G. Pereira
President and Director
February 7, 2006
/s/ Michael N. Avallone
Michael N. Avallone
Chief Financial Officer
February 7, 2006
/s/Sheldon Bloch
Sheldon Bloch
Director
February 7, 2006
/s/ Michael D. Loberg
Dr. Michael D. Loberg
Director
February 7, 2006
/s/ Edward B. Roberts
Dr. Edward B. Roberts
Director
February 7, 2006
/s/ Mark Skaletsky
Mark Skaletsky
Director
February 7, 2006
/s/ Theodore I. Steinman
Theodore I. Steinman, MD
Director
February 7, 2006