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    <td>
    <p ALIGN="JUSTIFY"><font SIZE="2">As filed with the Securities and Exchange
    Commission on April 29, 2005 </font></td>
    <td><font SIZE="2">Registration No. 333-________</font></td>
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  <tr>
    <td style="border-bottom: 1px solid #000000">&nbsp;</td>
    <td style="border-bottom: 1px solid #000000">&nbsp;</td>
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<u>
<p ALIGN="JUSTIFY"></p>
</u><b>
<p ALIGN="CENTER"></p>
<p ALIGN="CENTER">SECURITIES AND EXCHANGE COMMISSION</b> <br>
<b>Washington, D.C. 20549<br>
</b>______________________</p>
<b>
<p ALIGN="CENTER">FORM S-8<br>
REGISTRATION STATEMENT<br>
UNDER<br>
THE SECURITIES ACT OF 1933</p>
</b><u>
<p ALIGN="CENTER"></p>
</u></font><font SIZE="4"><b>
<p ALIGN="CENTER"></p>
<p ALIGN="CENTER">Minrad International, Inc.<br>
</b></font><font SIZE="2">(Exact name of registrant as specified in its charter)</p>
<p ALIGN="CENTER"></p>
</font>
<div align="center">
  <center>
  <table CELLSPACING="0" BORDER="0" CELLPADDING="0" WIDTH="638">
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      <td WIDTH="50%" VALIGN="TOP" style="border-bottom: 1px solid #000000" align="center">
      <font SIZE="2">Delaware</font></td>
      <td WIDTH="50%" VALIGN="TOP" style="border-bottom: 1px solid #000000">
      <font SIZE="2">
      <p ALIGN="center">870299034</font></td>
    </tr>
    <tr>
      <td WIDTH="50%" VALIGN="TOP" HEIGHT="30" align="center"><font SIZE="2">
      (State or other jurisdiction of<br>
      incorporation or organization)</font></td>
      <td WIDTH="50%" VALIGN="TOP" HEIGHT="30"><font SIZE="2">
      <p ALIGN="center">(I.R.S.Employer Identification No.)</font></td>
    </tr>
    <tr>
      <td WIDTH="50%" VALIGN="TOP" HEIGHT="30" align="center">&nbsp;</td>
      <td WIDTH="50%" VALIGN="TOP" HEIGHT="30">&nbsp;</td>
    </tr>
    <tr>
      <td WIDTH="100%" VALIGN="bottom" HEIGHT="30" align="center" colspan="2" style="border-bottom: 1px solid #000000">
      <font SIZE="2">
      <p ALIGN="CENTER">847 Main Street, Buffalo, New York 14203</font></td>
    </tr>
    <tr>
      <td WIDTH="100%" VALIGN="TOP" HEIGHT="30" align="center" colspan="2">
      <font SIZE="2">
      <p ALIGN="CENTER">(Address of Principal Executive Offices, Including Zip
      Code)</font></td>
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  </table>
  </center>
</div>
<font SIZE="2">
<p ALIGN="CENTER"></p>
</font><font SIZE="4"><b>
<p ALIGN="CENTER">Minrad International, Inc. 2004 Stock Option Plan<br>
Minrad International, Inc. 2005 Director Compensation Plan<br>
</b></font><font SIZE="2">(Full Title of the Plan)</p>
</font><font SIZE="3">
<p ALIGN="JUSTIFY"></p>
</font>
<table CELLSPACING="0" BORDER="0" CELLPADDING="0" WIDTH="638">
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    <td WIDTH="50%" VALIGN="TOP">&nbsp;</td>
    <td WIDTH="50%" VALIGN="TOP"><font SIZE="3">
    <p ALIGN="JUSTIFY">Copy to:</font></td>
  </tr>
  <tr>
    <td WIDTH="50%" VALIGN="TOP"><font SIZE="3">William H. Burns, Jr. President
    and CEO</font></td>
    <td WIDTH="50%" VALIGN="TOP"><font SIZE="3">Ward B. Hinkle, Esq.</font></td>
  </tr>
  <tr>
    <td WIDTH="50%" VALIGN="TOP"><font SIZE="3">847 Main Street</font></td>
    <td WIDTH="50%" VALIGN="TOP"><font SIZE="3">Hodgson Russ LLP</font></td>
  </tr>
  <tr>
    <td WIDTH="50%" VALIGN="TOP"><font SIZE="3">
    <p ALIGN="JUSTIFY">Buffalo, New York 14203</font></td>
    <td WIDTH="50%" VALIGN="TOP"><font SIZE="3">One M&amp;T Plaza-Suite 2000</font></td>
  </tr>
  <tr>
    <td WIDTH="50%" VALIGN="TOP"><font SIZE="3">(716) 855-1068</font></td>
    <td WIDTH="50%" VALIGN="TOP"><font SIZE="3">
    <p ALIGN="JUSTIFY">Buffalo, New York 14203</font></td>
  </tr>
  <tr>
    <td WIDTH="50%" VALIGN="TOP"><font SIZE="3">(Name, address and telephone<br>
    number of agent for service)</font></td>
    <td WIDTH="50%" VALIGN="TOP"><font SIZE="3">(716) 856-4000</font></td>
  </tr>
</table>
<font SIZE="2"><b>
<p ALIGN="JUSTIFY"></p>
</b></font>
<table BORDER="0" CELLSPACING="0" CELLPADDING="0" WIDTH="638">
  <tr>
    <td WIDTH="100%" VALIGN="BOTTOM" COLSPAN="6">&nbsp;</td>
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    <td WIDTH="100%" VALIGN="BOTTOM" COLSPAN="6"><font SIZE="2"><b><u>
    <p ALIGN="CENTER">Calculation of Registration Fee</u></b></font></td>
  </tr>
  <tr>
    <td WIDTH="29%" VALIGN="BOTTOM" COLSPAN="2">&nbsp;</td>
    <td WIDTH="17%" VALIGN="BOTTOM">&nbsp;</td>
    <td WIDTH="19%" VALIGN="BOTTOM">&nbsp;</td>
    <td WIDTH="19%" VALIGN="BOTTOM">&nbsp;</td>
    <td WIDTH="16%" VALIGN="BOTTOM">&nbsp;</td>
  </tr>
  <tr>
    <td WIDTH="29%" VALIGN="BOTTOM" COLSPAN="2" style="border-bottom: 1px solid #000000">
    <font SIZE="2">
    <p ALIGN="CENTER">Title of Securities<br>
    to be Registered</font></td>
    <td WIDTH="17%" VALIGN="BOTTOM" style="border-bottom: 1px solid #000000">
    <font SIZE="2">
    <p ALIGN="CENTER">Amount to be<u> </u>Registered</font></td>
    <td WIDTH="19%" VALIGN="BOTTOM" style="border-bottom: 1px solid #000000">
    <font SIZE="2">
    <p ALIGN="CENTER">Proposed Maximum Offering Price Per Share</font></td>
    <td WIDTH="19%" VALIGN="BOTTOM" style="border-bottom: 1px solid #000000">
    <font SIZE="2">
    <p ALIGN="CENTER">Proposed Maximum Aggregate Offering<u> </u>Price(1)</font></td>
    <td WIDTH="16%" VALIGN="BOTTOM" style="border-bottom: 1px solid #000000">
    <font SIZE="2">
    <p ALIGN="CENTER">Amount of Registration Fee</font></td>
  </tr>
  <tr>
    <td WIDTH="29%" VALIGN="TOP" COLSPAN="2">&nbsp;</td>
    <td WIDTH="17%" VALIGN="TOP">&nbsp;</td>
    <td WIDTH="19%" VALIGN="TOP">&nbsp;</td>
    <td WIDTH="19%" VALIGN="TOP">&nbsp;</td>
    <td WIDTH="16%" VALIGN="TOP">&nbsp;</td>
  </tr>
  <tr>
    <td WIDTH="29%" VALIGN="TOP" COLSPAN="2"><font SIZE="2">Common Stock, par
    value $.01</font></td>
    <td WIDTH="17%" VALIGN="TOP"><font SIZE="2">
    <p ALIGN="CENTER">7,220,500</font></td>
    <td WIDTH="19%" VALIGN="TOP"><font SIZE="2">
    <p ALIGN="CENTER">$3.925</font></td>
    <td WIDTH="19%" VALIGN="TOP"><font SIZE="2">
    <p ALIGN="CENTER">$28,340,462</font></td>
    <td WIDTH="16%" VALIGN="TOP"><font SIZE="2">
    <p ALIGN="CENTER">$3,335.67</font></td>
  </tr>
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    <td WIDTH="29%" VALIGN="TOP" COLSPAN="2">&nbsp;</td>
    <td WIDTH="17%" VALIGN="TOP">&nbsp;</td>
    <td WIDTH="19%" VALIGN="TOP">&nbsp;</td>
    <td WIDTH="19%" VALIGN="TOP">&nbsp;</td>
    <td WIDTH="16%" VALIGN="TOP">&nbsp;</td>
  </tr>
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    <td WIDTH="7%" VALIGN="TOP"><font SIZE="2">(1)</font></td>
    <td WIDTH="93%" VALIGN="TOP" COLSPAN="5"><font SIZE="2">Estimated solely for
    the purpose of calculating the registration fee in accordance with Rule
    457(c) and based upon the average of the reported bid and asked prices for
    the shares on the NASD OTC Bulletin Board on April 22, 2005.</font></td>
  </tr>
</table>
<font SIZE="2"><u><b>
<p ALIGN="CENTER"></p>
    </b></u>
    <p ALIGN="JUSTIFY"></p>
    <p ALIGN="JUSTIFY"></p>
    </font><font SIZE="3">
    <p ALIGN="right">1</p>
    <P style=PAGE-BREAK-BEFORE:always>
    <b>
    <p ALIGN="CENTER">PART I</p>
    </b>

<p>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; Information required by Part I to
be contained in the Section 10(a) prospectus is omitted from this Registration
Statement in accordance with Rule 428 under the Securities Act of 1933 and the
Note to Part 1 of Form S-8.</p>
</font><font FACE="Garamond" SIZE="2">
<p ALIGN="JUSTIFY"></p>
</font><b><font FACE="Garamond" SIZE="3">
<p>&nbsp;</p>
</font><font SIZE="3">
<p ALIGN="CENTER">PART II</p>
</font></b><font SIZE="3">
<p ALIGN="CENTER"></p>
<p ALIGN="center"><b>Information Required in the Registration Statement</p>
<p ALIGN="JUSTIFY"></p>
<p ALIGN="JUSTIFY">ITEM 3. Incorporation of Documents by Reference.</p>
</b>
<p ALIGN="JUSTIFY"></p>
<p ALIGN="JUSTIFY">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; The following
documents filed with the Securities and Exchange Commission (&quot;SEC&quot;) by the
Registrant are incorporated by reference in this Registration Statement:</p>
<p ALIGN="JUSTIFY"></p>
<p ALIGN="JUSTIFY">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; (a)&nbsp;&nbsp;&nbsp;&nbsp;
The Registrant's Form 10-KSB Report for the Transition Period ended December 31,
2004 filed with the SEC on March 31, 2005;</p>
<p ALIGN="JUSTIFY"></p>
<p ALIGN="JUSTIFY">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; (b)&nbsp;&nbsp;&nbsp;&nbsp;
The Registrant's definitive Proxy Statement filed with the SEC on April 6, 2005;</p>
<p ALIGN="JUSTIFY"></p>
<p ALIGN="JUSTIFY">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; (c)&nbsp;&nbsp;&nbsp;&nbsp;
All reports filed by the Registrant with the SEC pursuant to Section 13(a) or
15(d) of the Securities Exchange Act, as amended (the &quot;Exchange Act&quot;) since
December 31, 2004; and </p>
<p ALIGN="JUSTIFY"></p>
<p>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; (d)&nbsp;&nbsp;&nbsp;&nbsp; The
description of the Registrant's common stock contained in its registration
statement under Section 12 of the Exchange Act, including any amendment or
report filed for the purpose of updating the description.</p>
<p>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; All documents filed by the
Registrant or by the Plan pursuant to Sections 13(a), 13(c), 14 or 15(d) of the
Exchange Act prior to the filing of a post-effective amendment which indicates
that all securities offered have been sold or which deregisters all securities
then remaining unsold are incorporated by reference in this Registration
Statement and are a part hereof from the date of filing such documents.</p>
<p>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; Any statement contained in a
document incorporated by reference or deemed to be incorporated by reference in
this Registration Statement shall be deemed to be modified or superseded for
purposes of this Registration Statement to the extent that a statement contained
in this Registration Statement or in any other subsequently filed document that
is also deemed to be incorporated by reference in this Registration Statement
modifies or supersedes the statement. Any such statement so modified or
superseded shall not be deemed, except as so modified or superseded, to
constitute a part of this Registration Statement. </p>
<p ALIGN="JUSTIFY"></p>
<b>
<p ALIGN="JUSTIFY">ITEM 4 Description of Securities.</p>
</b>
<p ALIGN="JUSTIFY"></p>
<p ALIGN="JUSTIFY">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; Not applicable.</p>
<p ALIGN="JUSTIFY"></p>
<b>
<p ALIGN="JUSTIFY">ITEM 5. Interests of Named Experts and Counsel.</p>
</b>
<p ALIGN="JUSTIFY"></p>
<p ALIGN="JUSTIFY">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; None. </p>
<p ALIGN="JUSTIFY"></p>
<b>
<p ALIGN="JUSTIFY">ITEM 6. Indemnification of Directors and Officers.</p>
</b>
<p ALIGN="right">2</p>
<P style=PAGE-BREAK-BEFORE:always>
<p ALIGN="JUSTIFY"></p>
<p>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; Reference is made to Section
102(b)(7) of the Delaware General Corporation Law (the &quot;DGCL&quot;), which enables a
corporation in its original certificate of incorporation or an amendment thereto
to eliminate or limit the personal liability of a director for violations of the
director's fiduciary duty, except (i) for any breach of the director's duty of
loyalty to the corporation or its stockholders, (ii) for acts or omissions not
in good faith or which involve intentional misconduct or a knowing violation of
law, (iii) pursuant to Section 174 of the DGCL (providing for liability of
directors for unlawful payment of dividends or unlawful stock purchases or
redemptions) or (iv) for any transaction from which a director derived an
improper personal benefit.</p>
<p>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; Paragraph 10 of the Registrant's
Certificate of Incorporation provides that, to the extent permitted by the DGCL
(or any statute succeeding such law), as such law now exists or may hereafter be
amended, no director of the Corporation shall be personally liable to the
Corporation or its stockholders for monetary damages for any breach of fiduciary
duty as a director during the time that Paragraph 10 is in effect.</p>
<p>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; Reference is also made to Section
145 of the DGCL, which provides that a corporation may indemnify any persons,
including officers and directors, who are, or are threatened to be made, parties
to any threatened, pending or completed legal action, suit or proceeding,
whether civil, criminal, administrative or investigative (other than an action
by or in the right of such corporation), by reason of the fact that such person
was an officer, director, employee or agent of such corporation, or is or was
serving at the request of such corporation as a officer, director, employee or
agent of another corporation or enterprise. The indemnity may include expenses
(including attorneys' fees), judgments, fines and amounts paid in settlement
actually and reasonably incurred by such person in connection with such action,
suit or proceeding, provided such officer, director, employee or agent acted in
good faith and in a manner he or she reasonably believed to be in or not opposed
to the corporation's best interests and, for criminal proceedings, had no
reasonable cause to believe that his or her conduct was unlawful. A Delaware
corporation may indemnify officers and directors in an action by or in the right
of the corporation under the same conditions, except that no indemnification is
permitted without judicial approval if the officer or director is a adjudged to
be liable to the corporation. Where an officer or director is successful on the
merits or otherwise in the defense of any action referred to above, the
corporation must indemnify him or her against the expenses which such officer or
director actually and reasonably incurred.</p>
<p>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; The Bylaws of the Registrant
provide for indemnification of officers and directors, including indemnification
for expenses, to the fullest extent permitted by applicable law. </p>
<p>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; The Registrant may enter into
contracts with its officers and directors requiring the Registrant to indemnify
them and to advance litigation expenses to them to the fullest extent permitted
by applicable law. Delaware law presently permits a Delaware corporation (i) to
indemnify any officer or director in any third party or governmental actions
against them for expenses, judgments, fines and amounts paid in settlement and,
in derivative actions, for expenses, if the indemnitee acted in good faith and
in a manner he or she believed to be in or not opposed to the best interests of
such corporation, and (ii) to advance expenses in any action provided that the
officer or director agrees to reimburse the corporation if it is ultimately
determined that he or she was not entitled to indemnification. Such contracts
may require the Registrant to (i) indemnify such officers and directors upon
receipt of an opinion of counsel in certain cases, (ii) pay indemnitee demands
pending a determination of entitlement thereto, and (iii) demonstrate, in any
action brought thereunder, that such officer or director was not entitled to
indemnification under applicable law.</p>
<p align="right">3</p>
<P style=PAGE-BREAK-BEFORE:always>
<p>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; Under the DGCL, the Board of
Directors may authorize, by a vote of the majority of a quorum of the Board of
Directors, the Registrant to purchase and maintain insurance on behalf of any
person who is or was a director, officer, employee or agent of the Registrant,
or is or was serving at the request of the Registrant as a director, officer,
employee or agent of another corporation, partnership, joint venture, trust or
other enterprise, against any liability asserted against him or her and incurred
by him or her in any such capacity, or arising out of his or her status as such,
whether or not the Registrant would have the power to indemnify him or her
against such liability under the Bylaws.</p>
<p ALIGN="JUSTIFY"></p>
<b>
<p ALIGN="JUSTIFY">ITEM 7. Exemption from Registration Claimed.</p>
</b>
<p ALIGN="JUSTIFY"></p>
<p ALIGN="JUSTIFY">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; Not applicable.</p>
<p ALIGN="JUSTIFY"></p>
<b>
<p ALIGN="JUSTIFY">ITEM 8. Exhibits.</p>
</b>
<p ALIGN="JUSTIFY"></p>
<table border="0" width="672" id="AutoNumber2" cellspacing="0" cellpadding="0">
  <tr>
    <td width="43">&nbsp;</td>
    <td width="42" valign="top"><font SIZE="3">4.1 </font></td>
    <td width="577"><font SIZE="3">Minrad International, Inc. 2004 Stock Option
    Plan - incorporated by reference to Appendix C to the Registrant's
    definitive Information Statement, as filed with the SEC on September 16,
    2004.</font></td>
  </tr>
  <tr>
    <td width="43">&nbsp;</td>
    <td width="42" valign="top">&nbsp;</td>
    <td width="577">&nbsp;</td>
  </tr>
  <tr>
    <td width="43">&nbsp;</td>
    <td width="42" valign="top"><font SIZE="3">4.2 </font></td>
    <td width="577">
    <p ALIGN="JUSTIFY"><font SIZE="3">Minrad International, Inc., Director
    Compensation Plan -- incorporated by reference to Appendix B to the
    Registrant's definitive proxy statement filed with the SEC on April 6, 2005.
    </font></td>
  </tr>
  <tr>
    <td width="43">&nbsp;</td>
    <td width="42" valign="top">&nbsp;</td>
    <td width="577">&nbsp;</td>
  </tr>
  <tr>
    <td width="43">&nbsp;</td>
    <td width="42" valign="top"><font SIZE="3">5. </font></td>
    <td width="577">
    <p ALIGN="JUSTIFY"><font SIZE="3">Opinion of Hodgson Russ LLP as to legality
    of securities being registered - filed herewith.</font></td>
  </tr>
  <tr>
    <td width="43">&nbsp;</td>
    <td width="42" valign="top">&nbsp;</td>
    <td width="577">&nbsp;</td>
  </tr>
  <tr>
    <td width="43">&nbsp;</td>
    <td width="42" valign="top"><font SIZE="3">23. </font></td>
    <td width="577">
    <p ALIGN="JUSTIFY"><font SIZE="3">(a) Consent of Hodgson Russ LLP -
    contained in Exhibit 5, filed herewith.</font></td>
  </tr>
  <tr>
    <td width="43">&nbsp;</td>
    <td width="42" valign="top">&nbsp;</td>
    <td width="577">&nbsp;</td>
  </tr>
  <tr>
    <td width="43">&nbsp;</td>
    <td width="42" valign="top">&nbsp;</td>
    <td width="577">
    <p ALIGN="JUSTIFY"><font SIZE="3">(b) Consent of Freed Maxick &amp; Battaglia,
    CPAs, PC - filed herewith.</font></td>
  </tr>
</table>
<p ALIGN="JUSTIFY"></p>
<p ALIGN="JUSTIFY"></p>
<b>
<p ALIGN="JUSTIFY">ITEM 9. Undertakings. </p>
</b>
<p ALIGN="JUSTIFY"></p>
<p>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; (a) The undersigned Registrant
hereby undertakes:</p>
<p ALIGN="JUSTIFY"></p>
<p>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;
(1) To file, during any period in which offers or sales are being made, a
post-effective amendment to this registration statement:</p>
<p ALIGN="JUSTIFY"></p>
<p>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;
(i) to include any prospectus required by section 10(a)(3) of the Securities Act
of 1933; </p>
<p ALIGN="JUSTIFY"></p>
<p>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;
(ii) to reflect in the prospectus any facts or events arising after the
effective date of the registration statement (or the most recent post-effective
amendment thereof) which, individually or in the aggregate, represent a
fundamental change in the information set forth in the registration statement.
Notwithstanding the foregoing, any increase or decrease in volume of securities
offered (if the total dollar value of securities offered would not exceed that
which was registered) and any deviation from the low or high end of the
estimated maximum offering range may be reflected in the form of prospectus
filed with the Commission pursuant to Rule 424(b) (Regulation 230.424(b) of the
Commission) if, in the aggregate, the changes in volume and price represent no
more than a 20% change in the maximum aggregate offering price set forth in the
&quot;Calculation of Registration Fee&quot; table in the effective registration statement;
</p>
<p align="right">4</p>
<P style=PAGE-BREAK-BEFORE:always>
<p ALIGN="JUSTIFY"></p>
<p>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;
(iii) to include any material information with respect to the plan of
distribution not previously disclosed in the registration statement or any
material change to such information in the registration statement; provided,
however, that paragraphs (a)(1)(i) and (a)(1)(ii) do not apply if the
registration statement is on Form S-3 or Form S-8, and the information required
to be included in a post-effective amendment by those paragraphs is contained in
periodic reports filed by the Registrant pursuant to Section 13 or Section 15(d)
of the Securities Exchange Act of 1934 that are incorporated by reference in the
registration statement;</p>
<p ALIGN="JUSTIFY"></p>
<p>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;
(2) That, for the purpose of determining any liability under the Securities Act
of 1933, each post-effective amendment shall be deemed to be a new registration
statement relating to the securities offered therein, and the offering of such
securities at that time shall be deemed to be the initial bona fide offering
thereof; and</p>
<p ALIGN="JUSTIFY"></p>
<p>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;
(3) To remove from registration by means of a post-effective amendment any of
the securities being registered which remain unsold at the termination of the
offering.</p>
<p ALIGN="JUSTIFY"></p>
<p>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; (b) The undersigned Registrant
hereby undertakes that, for purposes of determining any liability under the
Securities Act of 1933, each filing of the Registrant's annual report pursuant
to Section 13(a) or Section 15(d) of the Securities Exchange Act of 1934 that is
incorporated by reference in the registration statement shall be deemed to be a
new registration statement relating to the securities offered therein, and the
offering of such securities at that time shall be deemed to be the initial bona
fide offering thereof. </p>
<p ALIGN="JUSTIFY"></p>
<p>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; (c) The undersigned registrant
hereby undertakes to deliver or cause to be delivered with the prospectus, to
each person to whom the prospectus is sent or given, the latest annual report to
security holders that is incorporated by reference in the prospectus and
furnished pursuant to and meeting the requirements of Rule 14a-3 or Rule 14c-3
under the Securities Exchange Act of 1934; and, where interim financial
information required to be presented by Article 3 of Regulations S-X is not set
forth in the prospectus, to deliver, or cause to be delivered to each person to
whom the prospectus is sent or given, the latest quarterly report that is
specifically incorporated by reference in the prospectus to provide such interim
financial information.</p>
<p ALIGN="JUSTIFY"></p>
<p>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; (d) Insofar as indemnification for
liabilities arising under the Securities Act of 1933 may be permitted to
directors, officers and controlling persons of the Registrant pursuant to the
foregoing provisions, or otherwise, the Registrant has been advised that in the
opinion of the Securities and Exchange Commission such indemnification is
against public policy as expressed in such Act and is, therefore, unenforceable.
In the event that a claim for indemnification against such liabilities (other
than the payment by the Registrant of expenses incurred or paid by a director,
officer or controlling person of the Registrant in the successful defense of any
action, suit or proceeding) is asserted by such director, officer or controlling
person in connection with the securities being registered, the Registrant will,
unless in the opinion of its counsel the matter has been settled by controlling
precedent, submit to a court of appropriate jurisdiction the question whether
such indemnification by it is against public policy as expressed in the Act and
will be governed by the final adjudication of such issue.</p>
<p ALIGN="JUSTIFY"></p>
<p ALIGN="center">[Remainder of Page Intentionally Left Blank]</p>
<p ALIGN="JUSTIFY"></p>
<p ALIGN="right">5</p>
<P style=PAGE-BREAK-BEFORE:always>
<p ALIGN="center"><b>SIGNATURES</p>
<p ALIGN="JUSTIFY"></p>
</b>
<p>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; Pursuant to the requirements of
the Securities Act of 1933, the Registrant certifies that it has reasonable
grounds to believe that it meets all of the requirements for filing on Form S-8
and has duly caused this registration statement to be signed on its behalf by
the undersigned, thereunto duly authorized, in the City of Buffalo, State of New
York, on April 21, 2005. </p>
<p ALIGN="JUSTIFY"></p>
<p ALIGN="JUSTIFY">&nbsp;</p>
</font>
<table BORDER="0" CELLSPACING="0" CELLPADDING="0" WIDTH="638">
  <tr>
    <td WIDTH="42%" VALIGN="TOP">&nbsp;</td>
    <td WIDTH="58%" VALIGN="TOP" COLSPAN="2"><font SIZE="3">
    <p ALIGN="JUSTIFY">MINRAD INTERNATIONAL, INC.</font></td>
  </tr>
  <tr>
    <td WIDTH="42%" VALIGN="TOP">&nbsp;</td>
    <td WIDTH="58%" VALIGN="TOP" COLSPAN="2">&nbsp;</td>
  </tr>
  <tr>
    <td WIDTH="42%" VALIGN="TOP">&nbsp;</td>
    <td WIDTH="6%" VALIGN="TOP"><font SIZE="3">
    <p ALIGN="JUSTIFY">BY:</font></td>
    <td WIDTH="51%" VALIGN="TOP" style="border-bottom: 1px solid #000000">
    <font SIZE="3"><i>
    <p ALIGN="JUSTIFY">/S/ William H. Burns, Jr.</i></font></td>
  </tr>
  <tr>
    <td WIDTH="42%" VALIGN="TOP">&nbsp;</td>
    <td WIDTH="6%" VALIGN="TOP">&nbsp;</td>
    <td WIDTH="51%" VALIGN="TOP"><font SIZE="3">
    <p ALIGN="JUSTIFY">William H. Burns, Jr.</font></td>
  </tr>
  <tr>
    <td WIDTH="42%" VALIGN="TOP">&nbsp;</td>
    <td WIDTH="6%" VALIGN="TOP">&nbsp;</td>
    <td WIDTH="51%" VALIGN="TOP"><font SIZE="3">
    <p ALIGN="JUSTIFY">Chairman, President and Chief Executive Officer</font></td>
  </tr>
</table>
<font SIZE="3">
<p ALIGN="JUSTIFY"></p>
<p ALIGN="JUSTIFY">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; Pursuant to the
requirements of the Securities Act of 1933, this registration statement has been
signed by the following persons in the capacities and on the dates indicated.</p>
<p ALIGN="JUSTIFY"></p>
</font>
<table BORDER="0" CELLSPACING="0" CELLPADDING="0" WIDTH="638">
  <tr>
    <td WIDTH="35%" VALIGN="BOTTOM"><font SIZE="3"><u>
    <p ALIGN="JUSTIFY">Signature</u></font></td>
    <td WIDTH="4%" VALIGN="TOP">&nbsp;</td>
    <td WIDTH="41%" VALIGN="BOTTOM"><font SIZE="3"><u>
    <p ALIGN="CENTER">Title</u></font></td>
    <td WIDTH="20%" VALIGN="BOTTOM"><font SIZE="3"><u>
    <p ALIGN="CENTER">Date</u></font></td>
  </tr>
  <tr>
    <td WIDTH="35%" VALIGN="BOTTOM">&nbsp;</td>
    <td WIDTH="4%" VALIGN="TOP">&nbsp;</td>
    <td WIDTH="41%" VALIGN="BOTTOM">&nbsp;</td>
    <td WIDTH="20%" VALIGN="BOTTOM">&nbsp;</td>
  </tr>
  <tr>
    <td WIDTH="35%" VALIGN="BOTTOM">&nbsp;</td>
    <td WIDTH="4%" VALIGN="TOP">&nbsp;</td>
    <td WIDTH="41%" VALIGN="BOTTOM">&nbsp;</td>
    <td WIDTH="20%" VALIGN="BOTTOM">&nbsp;</td>
  </tr>
  <tr>
    <td WIDTH="35%" VALIGN="BOTTOM"><font SIZE="3">(a) Principal Executive
    Officer</font></td>
    <td WIDTH="4%" VALIGN="TOP">&nbsp;</td>
    <td WIDTH="41%" VALIGN="BOTTOM">&nbsp;</td>
    <td WIDTH="20%" VALIGN="BOTTOM">&nbsp;</td>
  </tr>
  <tr>
    <td WIDTH="35%" VALIGN="BOTTOM">&nbsp;</td>
    <td WIDTH="4%" VALIGN="TOP">&nbsp;</td>
    <td WIDTH="41%" VALIGN="BOTTOM">&nbsp;</td>
    <td WIDTH="20%" VALIGN="BOTTOM">&nbsp;</td>
  </tr>
  <tr>
    <td WIDTH="35%" VALIGN="BOTTOM" HEIGHT="34" style="border-bottom: 1px solid #000000">
    <font SIZE="3"><i>/S/ William H. Burns, Jr.</i></font></td>
    <td WIDTH="4%" VALIGN="TOP" HEIGHT="34"></td>
    <td WIDTH="41%" VALIGN="BOTTOM" HEIGHT="34"><font SIZE="3">Chairman, Chief
    Executive Officer and Director</font></td>
    <td WIDTH="20%" VALIGN="BOTTOM" HEIGHT="34"><font SIZE="3">
    <p ALIGN="CENTER">April 21, 2005</font></td>
  </tr>
  <tr>
    <td WIDTH="35%" VALIGN="BOTTOM"><font SIZE="3">William H. Burns, Jr.</font></td>
    <td WIDTH="4%" VALIGN="TOP">&nbsp;</td>
    <td WIDTH="41%" VALIGN="BOTTOM">&nbsp;</td>
    <td WIDTH="20%" VALIGN="BOTTOM">&nbsp;</td>
  </tr>
  <tr>
    <td WIDTH="35%" VALIGN="BOTTOM">&nbsp;</td>
    <td WIDTH="4%" VALIGN="TOP">&nbsp;</td>
    <td WIDTH="41%" VALIGN="BOTTOM">&nbsp;</td>
    <td WIDTH="20%" VALIGN="BOTTOM">&nbsp;</td>
  </tr>
  <tr>
    <td WIDTH="35%" VALIGN="BOTTOM">&nbsp;</td>
    <td WIDTH="4%" VALIGN="TOP">&nbsp;</td>
    <td WIDTH="41%" VALIGN="BOTTOM">&nbsp;</td>
    <td WIDTH="20%" VALIGN="BOTTOM">&nbsp;</td>
  </tr>
  <tr>
    <td WIDTH="35%" VALIGN="BOTTOM"><font SIZE="3">(b) Principal Financial
    Officer</font></td>
    <td WIDTH="4%" VALIGN="TOP">&nbsp;</td>
    <td WIDTH="41%" VALIGN="BOTTOM">&nbsp;</td>
    <td WIDTH="20%" VALIGN="BOTTOM">&nbsp;</td>
  </tr>
  <tr>
    <td WIDTH="35%" VALIGN="BOTTOM">&nbsp;</td>
    <td WIDTH="4%" VALIGN="TOP">&nbsp;</td>
    <td WIDTH="41%" VALIGN="BOTTOM">&nbsp;</td>
    <td WIDTH="20%" VALIGN="BOTTOM">&nbsp;</td>
  </tr>
  <tr>
    <td WIDTH="35%" VALIGN="BOTTOM" HEIGHT="51" style="border-bottom: 1px solid #000000">
    <font SIZE="3"><i>/S/ Richard Tamulski</i></font></td>
    <td WIDTH="4%" VALIGN="TOP" HEIGHT="51"></td>
    <td WIDTH="41%" VALIGN="BOTTOM" HEIGHT="51"><font SIZE="3">Vice President
    and Chief Financial Officer </font></td>
    <td WIDTH="20%" VALIGN="BOTTOM" HEIGHT="51"><font SIZE="3">
    <p ALIGN="CENTER">April 21, 2005</font></td>
  </tr>
  <tr>
    <td WIDTH="35%" VALIGN="BOTTOM"><font SIZE="3">Richard Tamulski</font></td>
    <td WIDTH="4%" VALIGN="TOP">&nbsp;</td>
    <td WIDTH="41%" VALIGN="BOTTOM">&nbsp;</td>
    <td WIDTH="20%" VALIGN="BOTTOM">&nbsp;</td>
  </tr>
  <tr>
    <td WIDTH="35%" VALIGN="BOTTOM">&nbsp;</td>
    <td WIDTH="4%" VALIGN="TOP">&nbsp;</td>
    <td WIDTH="41%" VALIGN="BOTTOM">&nbsp;</td>
    <td WIDTH="20%" VALIGN="BOTTOM">&nbsp;</td>
  </tr>
  <tr>
    <td WIDTH="35%" VALIGN="BOTTOM">&nbsp;</td>
    <td WIDTH="4%" VALIGN="TOP">&nbsp;</td>
    <td WIDTH="41%" VALIGN="BOTTOM">&nbsp;</td>
    <td WIDTH="20%" VALIGN="BOTTOM">&nbsp;</td>
  </tr>
  <tr>
    <td WIDTH="35%" VALIGN="BOTTOM"><font SIZE="3">(c) Principal Accounting
    Officer</font></td>
    <td WIDTH="4%" VALIGN="TOP">&nbsp;</td>
    <td WIDTH="41%" VALIGN="BOTTOM">&nbsp;</td>
    <td WIDTH="20%" VALIGN="BOTTOM">&nbsp;</td>
  </tr>
  <tr>
    <td WIDTH="35%" VALIGN="BOTTOM" HEIGHT="34" style="border-bottom: 1px solid #000000">
    <font SIZE="3"><i>/S/ William Rolfe</i></font></td>
    <td WIDTH="4%" VALIGN="TOP" HEIGHT="34"></td>
    <td WIDTH="41%" VALIGN="BOTTOM" HEIGHT="34"><font SIZE="3">Controller</font></td>
    <td WIDTH="20%" VALIGN="BOTTOM" HEIGHT="34"><font SIZE="3">
    <p ALIGN="CENTER">April 21, 2005</font></td>
  </tr>
  <tr>
    <td WIDTH="35%" VALIGN="BOTTOM"><font SIZE="3">William Rolfe</font></td>
    <td WIDTH="4%" VALIGN="TOP">&nbsp;</td>
    <td WIDTH="41%" VALIGN="BOTTOM">&nbsp;</td>
    <td WIDTH="20%" VALIGN="BOTTOM">&nbsp;</td>
  </tr>
  <tr>
    <td WIDTH="35%" VALIGN="BOTTOM">&nbsp;</td>
    <td WIDTH="4%" VALIGN="TOP">&nbsp;</td>
    <td WIDTH="41%" VALIGN="BOTTOM">&nbsp;</td>
    <td WIDTH="20%" VALIGN="BOTTOM">&nbsp;</td>
  </tr>
  <tr>
    <td WIDTH="35%" VALIGN="BOTTOM">&nbsp;</td>
    <td WIDTH="4%" VALIGN="TOP">&nbsp;</td>
    <td WIDTH="41%" VALIGN="BOTTOM">&nbsp;</td>
    <td WIDTH="20%" VALIGN="BOTTOM">&nbsp;</td>
  </tr>
  <tr>
    <td WIDTH="35%" VALIGN="BOTTOM"><font SIZE="3">(c) Directors</font></td>
    <td WIDTH="4%" VALIGN="TOP">&nbsp;</td>
    <td WIDTH="41%" VALIGN="BOTTOM">&nbsp;</td>
    <td WIDTH="20%" VALIGN="BOTTOM">&nbsp;</td>
  </tr>
  <tr>
    <td WIDTH="35%" VALIGN="BOTTOM" HEIGHT="34" style="border-bottom: 1px solid #000000">
    <font SIZE="3"><i>/S/ William H. Burns, Jr.</i></font></td>
    <td WIDTH="4%" VALIGN="TOP" HEIGHT="34"></td>
    <td WIDTH="41%" VALIGN="BOTTOM" HEIGHT="34"></td>
    <td WIDTH="20%" VALIGN="BOTTOM" HEIGHT="34"><font SIZE="3">
    <p ALIGN="CENTER">April 21, 2005</font></td>
  </tr>
  <tr>
    <td WIDTH="35%" VALIGN="BOTTOM"><font SIZE="3">William H. Burns, Jr. </font>
    </td>
    <td WIDTH="4%" VALIGN="TOP">&nbsp;</td>
    <td WIDTH="41%" VALIGN="BOTTOM">&nbsp;</td>
    <td WIDTH="20%" VALIGN="BOTTOM">&nbsp;</td>
  </tr>
  <tr>
    <td WIDTH="35%" VALIGN="BOTTOM">&nbsp;</td>
    <td WIDTH="4%" VALIGN="TOP">&nbsp;</td>
    <td WIDTH="41%" VALIGN="BOTTOM">&nbsp;</td>
    <td WIDTH="20%" VALIGN="BOTTOM">&nbsp;</td>
  </tr>
  <tr>
    <td WIDTH="35%" VALIGN="BOTTOM" style="border-bottom: 1px solid #000000">
    <font SIZE="3"><i>/S/ David DiGiacinto</i></font></td>
    <td WIDTH="4%" VALIGN="TOP">&nbsp;</td>
    <td WIDTH="41%" VALIGN="BOTTOM">&nbsp;</td>
    <td WIDTH="20%" VALIGN="BOTTOM">&nbsp;</td>
  </tr>
  <tr>
    <td WIDTH="35%" VALIGN="BOTTOM"><font SIZE="3">David DiGiacinto</font></td>
    <td WIDTH="4%" VALIGN="TOP">&nbsp;</td>
    <td WIDTH="41%" VALIGN="BOTTOM">&nbsp;</td>
    <td WIDTH="20%" VALIGN="BOTTOM"><font SIZE="3">
    <p ALIGN="CENTER">April 21, 2005</font></td>
  </tr>
</table>
<font FACE="Garamond">
<p align="right">6</p>
<P style=PAGE-BREAK-BEFORE:always></font>
<table BORDER="0" CELLSPACING="0" CELLPADDING="0" WIDTH="638">
  <tr>
    <td WIDTH="35%" VALIGN="BOTTOM" style="border-bottom: 1px solid #000000">
    <font SIZE="3"><i>/S/ David Donaldson</i></font></td>
    <td WIDTH="6%" VALIGN="TOP">&nbsp;</td>
    <td WIDTH="39%" VALIGN="BOTTOM">&nbsp;</td>
    <td WIDTH="20%" VALIGN="BOTTOM">&nbsp;</td>
  </tr>
  <tr>
    <td WIDTH="35%" VALIGN="BOTTOM"><font SIZE="3">David Donaldson</font></td>
    <td WIDTH="6%" VALIGN="TOP">&nbsp;</td>
    <td WIDTH="39%" VALIGN="BOTTOM">&nbsp;</td>
    <td WIDTH="20%" VALIGN="BOTTOM"><font SIZE="3">
    <p ALIGN="CENTER">April 21, 2005</font></td>
  </tr>
  <tr>
    <td WIDTH="35%" VALIGN="BOTTOM">&nbsp;</td>
    <td WIDTH="6%" VALIGN="TOP">&nbsp;</td>
    <td WIDTH="39%" VALIGN="BOTTOM">&nbsp;</td>
    <td WIDTH="20%" VALIGN="BOTTOM">&nbsp;</td>
  </tr>
  <tr>
    <td WIDTH="35%" VALIGN="BOTTOM" style="border-bottom: 1px solid #000000">
    <font SIZE="3"><i>/S/ Donald F. Farley</i></font></td>
    <td WIDTH="6%" VALIGN="TOP">&nbsp;</td>
    <td WIDTH="39%" VALIGN="BOTTOM">&nbsp;</td>
    <td WIDTH="20%" VALIGN="BOTTOM">&nbsp;</td>
  </tr>
  <tr>
    <td WIDTH="35%" VALIGN="BOTTOM"><font SIZE="3">Donald F. Farley</font></td>
    <td WIDTH="6%" VALIGN="TOP">&nbsp;</td>
    <td WIDTH="39%" VALIGN="BOTTOM">&nbsp;</td>
    <td WIDTH="20%" VALIGN="BOTTOM"><font SIZE="3">
    <p ALIGN="CENTER">April 21, 2005</font></td>
  </tr>
  <tr>
    <td WIDTH="35%" VALIGN="BOTTOM">&nbsp;</td>
    <td WIDTH="6%" VALIGN="TOP">&nbsp;</td>
    <td WIDTH="39%" VALIGN="BOTTOM">&nbsp;</td>
    <td WIDTH="20%" VALIGN="BOTTOM">&nbsp;</td>
  </tr>
  <tr>
    <td WIDTH="35%" VALIGN="BOTTOM" style="border-bottom: 1px solid #000000">
    <font SIZE="3"><i>/S/ Duane Hopper</i></font></td>
    <td WIDTH="6%" VALIGN="TOP">&nbsp;</td>
    <td WIDTH="39%" VALIGN="BOTTOM">&nbsp;</td>
    <td WIDTH="20%" VALIGN="BOTTOM">&nbsp;</td>
  </tr>
  <tr>
    <td WIDTH="35%" VALIGN="BOTTOM"><font SIZE="3">Duane Hopper</font></td>
    <td WIDTH="6%" VALIGN="TOP">&nbsp;</td>
    <td WIDTH="39%" VALIGN="BOTTOM">&nbsp;</td>
    <td WIDTH="20%" VALIGN="BOTTOM"><font SIZE="3">
    <p ALIGN="CENTER">April 21, 2005</font></td>
  </tr>
  <tr>
    <td WIDTH="35%" VALIGN="BOTTOM">&nbsp;</td>
    <td WIDTH="6%" VALIGN="TOP">&nbsp;</td>
    <td WIDTH="39%" VALIGN="BOTTOM">&nbsp;</td>
    <td WIDTH="20%" VALIGN="BOTTOM">&nbsp;</td>
  </tr>
  <tr>
    <td WIDTH="35%" VALIGN="BOTTOM" style="border-bottom: 1px solid #000000">
    <font SIZE="3"><i>/S/ Robert Lifeso</i></font></td>
    <td WIDTH="6%" VALIGN="TOP">&nbsp;</td>
    <td WIDTH="39%" VALIGN="BOTTOM">&nbsp;</td>
    <td WIDTH="20%" VALIGN="BOTTOM">&nbsp;</td>
  </tr>
  <tr>
    <td WIDTH="35%" VALIGN="BOTTOM"><font SIZE="3">
    <p ALIGN="JUSTIFY">Robert Lifeso</font></td>
    <td WIDTH="6%" VALIGN="TOP">&nbsp;</td>
    <td WIDTH="39%" VALIGN="BOTTOM">&nbsp;</td>
    <td WIDTH="20%" VALIGN="BOTTOM"><font SIZE="3">
    <p ALIGN="CENTER">April 21, 2005</font></td>
  </tr>
  <tr>
    <td WIDTH="35%" VALIGN="BOTTOM">&nbsp;</td>
    <td WIDTH="6%" VALIGN="TOP">&nbsp;</td>
    <td WIDTH="39%" VALIGN="BOTTOM">&nbsp;</td>
    <td WIDTH="20%" VALIGN="BOTTOM">&nbsp;</td>
  </tr>
  <tr>
    <td WIDTH="35%" VALIGN="BOTTOM" style="border-bottom: 1px solid #000000">
    <font SIZE="3"><i>
    <p ALIGN="JUSTIFY">/S/ John Rousseau</i></font></td>
    <td WIDTH="6%" VALIGN="TOP">&nbsp;</td>
    <td WIDTH="39%" VALIGN="BOTTOM">&nbsp;</td>
    <td WIDTH="20%" VALIGN="BOTTOM">&nbsp;</td>
  </tr>
  <tr>
    <td WIDTH="35%" VALIGN="BOTTOM"><font SIZE="3">
    <p ALIGN="JUSTIFY">John Rousseau</font></td>
    <td WIDTH="6%" VALIGN="TOP">&nbsp;</td>
    <td WIDTH="39%" VALIGN="BOTTOM">&nbsp;</td>
    <td WIDTH="20%" VALIGN="BOTTOM"><font SIZE="3">
    <p ALIGN="CENTER">April 21, 2005</font></td>
  </tr>
</table>
<font SIZE="3">
<p ALIGN="right">7</p>
<P style=PAGE-BREAK-BEFORE:always>
<p ALIGN="JUSTIFY">&nbsp;</p>
<p ALIGN="center"><b>EXHIBIT INDEX</p>
<p ALIGN="JUSTIFY"></p>
</b></font>
<table CELLSPACING="0" BORDER="0" CELLPADDING="0" WIDTH="638">
  <tr>
    <td WIDTH="18%" VALIGN="BOTTOM" HEIGHT="34"><font SIZE="3"><u>
    <p ALIGN="JUSTIFY">Exhibit No.</u></font></td>
    <td WIDTH="60%" VALIGN="BOTTOM" HEIGHT="34"><font SIZE="3"><u>
    <p ALIGN="JUSTIFY">Description</u></font></td>
    <td WIDTH="22%" VALIGN="BOTTOM" HEIGHT="34"><font SIZE="3">
    <p ALIGN="JUSTIFY">Page or <u>Reference </u></font></td>
  </tr>
  <tr>
    <td WIDTH="18%" VALIGN="TOP">&nbsp;</td>
    <td WIDTH="60%" VALIGN="TOP">&nbsp;</td>
    <td WIDTH="22%" VALIGN="TOP">&nbsp;</td>
  </tr>
  <tr>
    <td WIDTH="18%" VALIGN="TOP">&nbsp;</td>
    <td WIDTH="60%" VALIGN="TOP">&nbsp;</td>
    <td WIDTH="22%" VALIGN="TOP">&nbsp;</td>
  </tr>
  <tr>
    <td WIDTH="18%" VALIGN="TOP" HEIGHT="34"><font SIZE="3">
    <p ALIGN="JUSTIFY" style="margin-top: 0; margin-bottom: 0">4.1</font></td>
    <td WIDTH="60%" VALIGN="TOP" HEIGHT="34"><font SIZE="3">
    <p ALIGN="JUSTIFY" style="margin-top: 0; margin-bottom: 0">Minrad
    International, Inc. 2004 </p>
    <p ALIGN="JUSTIFY" style="margin-top: 0; margin-bottom: 0">Stock Option Plan</font></td>
    <td WIDTH="22%" VALIGN="TOP" HEIGHT="34"><font SIZE="3">
    <p ALIGN="JUSTIFY">(1)</font></td>
  </tr>
  <tr>
    <td WIDTH="18%" VALIGN="TOP">
    <p style="margin-top: 0; margin-bottom: 0">&nbsp;</td>
    <td WIDTH="60%" VALIGN="TOP">
    <p style="margin-top: 0; margin-bottom: 0">&nbsp;</td>
    <td WIDTH="22%" VALIGN="TOP">&nbsp;</td>
  </tr>
  <tr>
    <td WIDTH="18%" VALIGN="TOP" HEIGHT="34"><font SIZE="3">
    <p ALIGN="JUSTIFY" style="margin-top: 0; margin-bottom: 0">4.2</font></td>
    <td WIDTH="60%" VALIGN="TOP" HEIGHT="34"><font SIZE="3">
    <p ALIGN="JUSTIFY" style="margin-top: 0; margin-bottom: 0">Minrad
    International, Inc. 2005 Director</p>
    <p ALIGN="JUSTIFY" style="margin-top: 0; margin-bottom: 0">Compensation Plan</font></td>
    <td WIDTH="22%" VALIGN="TOP" HEIGHT="34"><font SIZE="3">
    <p ALIGN="JUSTIFY">(2)</font></td>
  </tr>
  <tr>
    <td WIDTH="18%" VALIGN="TOP">
    <p style="margin-top: 0; margin-bottom: 0">&nbsp;</td>
    <td WIDTH="60%" VALIGN="TOP">
    <p style="margin-top: 0; margin-bottom: 0">&nbsp;</td>
    <td WIDTH="22%" VALIGN="TOP">&nbsp;</td>
  </tr>
  <tr>
    <td WIDTH="18%" VALIGN="TOP" HEIGHT="34"><font SIZE="3">
    <p ALIGN="JUSTIFY" style="margin-top: 0; margin-bottom: 0">5</font></td>
    <td WIDTH="60%" VALIGN="TOP" HEIGHT="34"><font SIZE="3">
    <p ALIGN="JUSTIFY" style="margin-top: 0; margin-bottom: 0">Opinion of
    Hodgson Russ LLP as to</p>
    <p ALIGN="JUSTIFY" style="margin-top: 0; margin-bottom: 0">legality of
    securities being registered</font></td>
    <td WIDTH="22%" VALIGN="TOP" HEIGHT="34"><font SIZE="3">
    <p ALIGN="JUSTIFY">Page 9</font></td>
  </tr>
  <tr>
    <td WIDTH="18%" VALIGN="TOP">
    <p style="margin-top: 0; margin-bottom: 0">&nbsp;</td>
    <td WIDTH="60%" VALIGN="TOP">
    <p style="margin-top: 0; margin-bottom: 0">&nbsp;</td>
    <td WIDTH="22%" VALIGN="TOP">&nbsp;</td>
  </tr>
  <tr>
    <td WIDTH="18%" VALIGN="TOP" HEIGHT="34"><font SIZE="3">
    <p ALIGN="JUSTIFY" style="margin-top: 0; margin-bottom: 0">23 (a)</font></td>
    <td WIDTH="60%" VALIGN="TOP" HEIGHT="34"><font SIZE="3">
    <p ALIGN="JUSTIFY" style="margin-top: 0; margin-bottom: 0">Consent of
    Hodgson Russ LLP (included in Exhibit No. 5)</font></td>
    <td WIDTH="22%" VALIGN="TOP" HEIGHT="34"><font SIZE="3">
    <p ALIGN="JUSTIFY">Page 9</font></td>
  </tr>
  <tr>
    <td WIDTH="18%" VALIGN="TOP" HEIGHT="34"><font SIZE="3">
    <p ALIGN="JUSTIFY" style="margin-top: 0; margin-bottom: 0">23 (b)</font></td>
    <td WIDTH="60%" VALIGN="TOP" HEIGHT="34"><font SIZE="3">
    <p ALIGN="JUSTIFY" style="margin-top: 0; margin-bottom: 0">Consent of Freed
    Maxick &amp; Battaglia, CPAs, PC</font></td>
    <td WIDTH="22%" VALIGN="TOP" HEIGHT="34"><font SIZE="3">
    <p ALIGN="JUSTIFY">Page 10</font></td>
  </tr>
  <tr>
    <td WIDTH="18%" VALIGN="TOP" HEIGHT="1">
    <p style="margin-top: 0; margin-bottom: 0"></td>
    <td WIDTH="60%" VALIGN="TOP" HEIGHT="1">
    <p style="margin-top: 0; margin-bottom: 0"></td>
    <td WIDTH="22%" VALIGN="TOP" HEIGHT="1"></td>
  </tr>
  <tr>
    <td WIDTH="18%" VALIGN="TOP"><font SIZE="3">
    <p style="margin-top: 0; margin-bottom: 0">(1)</font></td>
    <td WIDTH="60%" VALIGN="TOP"><font SIZE="3">
    <p style="margin-top: 0; margin-bottom: 0">Filed as Appendix C to the
    Registrant's definitive Information Statement filed with the SEC on
    September 16, 2004 and incorporated herein by reference.</font></td>
    <td WIDTH="22%" VALIGN="TOP">&nbsp;</td>
  </tr>
  <tr>
    <td WIDTH="18%" VALIGN="TOP">
    <p style="margin-top: 0; margin-bottom: 0">&nbsp;</td>
    <td WIDTH="60%" VALIGN="TOP">
    <p style="margin-top: 0; margin-bottom: 0">&nbsp;</td>
    <td WIDTH="22%" VALIGN="TOP">&nbsp;</td>
  </tr>
  <tr>
    <td WIDTH="18%" VALIGN="TOP"><font SIZE="3">
    <p ALIGN="JUSTIFY" style="margin-top: 0; margin-bottom: 0">(2)</font></td>
    <td WIDTH="60%" VALIGN="TOP"><font SIZE="3">
    <p ALIGN="JUSTIFY" style="margin-top: 0; margin-bottom: 0">Filed as Appendix
    B to the Registrant's definitive Proxy Statement filed with the SEC on April
    6, 2005.</font></td>
    <td WIDTH="22%" VALIGN="TOP">&nbsp;</td>
  </tr>
</table>
<font FACE="Garamond" SIZE="3">
<p ALIGN="JUSTIFY"></p>
</font><font FACE="Times New Roman">
<p ALIGN="right">8</p>
</body>

</html>
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{"company-data": {"conformed-name": "MINRAD INTERNATIONAL, INC.", "cik": "0001121225", "assigned-sic": "3841", "irs-number": "872099034", "state-of-incorporation": "NV", "fiscal-year-end": "1231"}, "filing-values": {"form-type": "S-8", "act": "33", "file-number": "333-124470", "film-number": "05785982"}, "business-address": {"street1": "847 MAIN ST.", "city": "BUFFALO", "state": "NY", "zip": "14203", "phone": "716-855-1068"}, "mail-address": {"street1": "847 MAIN ST.", "city": "BUFFALO", "state": "NY", "zip": "14203"}, "former-company": {"former-conformed-name": "TECHNOLOGY ACQUISITION CORP", "date-changed": "20000804"}}
Form S-8
As filed with the Securities and Exchange
    Commission on April 29, 2005
Registration No. 333-________
SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
______________________
FORM S-8
REGISTRATION STATEMENT
UNDER
THE SECURITIES ACT OF 1933
Minrad International, Inc.
(Exact name of registrant as specified in its charter)
Delaware
870299034
(State or other jurisdiction of
incorporation or organization)
(I.R.S.Employer Identification No.)
847 Main Street, Buffalo, New York 14203
(Address of Principal Executive Offices, Including Zip
      Code)
Minrad International, Inc. 2004 Stock Option Plan
Minrad International, Inc. 2005 Director Compensation Plan
(Full Title of the Plan)
Copy to:
William H. Burns, Jr. President
    and CEO
Ward B. Hinkle, Esq.
847 Main Street
Hodgson Russ LLP
Buffalo, New York 14203
One M&T Plaza-Suite 2000
(716) 855-1068
Buffalo, New York 14203
(Name, address and telephone
number of agent for service)
(716) 856-4000
Calculation of Registration Fee
Title of Securities
to be Registered
Amount to be
Registered
Proposed Maximum Offering Price Per Share
Proposed Maximum Aggregate Offering
Price(1)
Amount of Registration Fee
Common Stock, par
    value $.01
7,220,500
$3.925
$28,340,462
$3,335.67
(1)
Estimated solely for
    the purpose of calculating the registration fee in accordance with Rule
    457(c) and based upon the average of the reported bid and asked prices for
    the shares on the NASD OTC Bulletin Board on April 22, 2005.
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PART I
Information required by Part I to
be contained in the Section 10(a) prospectus is omitted from this Registration
Statement in accordance with Rule 428 under the Securities Act of 1933 and the
Note to Part 1 of Form S-8.
PART II
Information Required in the Registration Statement
ITEM 3. Incorporation of Documents by Reference.
The following
documents filed with the Securities and Exchange Commission ("SEC") by the
Registrant are incorporated by reference in this Registration Statement:
(a)    
The Registrant's Form 10-KSB Report for the Transition Period ended December 31,
2004 filed with the SEC on March 31, 2005;
(b)    
The Registrant's definitive Proxy Statement filed with the SEC on April 6, 2005;
(c)    
All reports filed by the Registrant with the SEC pursuant to Section 13(a) or
15(d) of the Securities Exchange Act, as amended (the "Exchange Act") since
December 31, 2004; and
(d)     The
description of the Registrant's common stock contained in its registration
statement under Section 12 of the Exchange Act, including any amendment or
report filed for the purpose of updating the description.
All documents filed by the
Registrant or by the Plan pursuant to Sections 13(a), 13(c), 14 or 15(d) of the
Exchange Act prior to the filing of a post-effective amendment which indicates
that all securities offered have been sold or which deregisters all securities
then remaining unsold are incorporated by reference in this Registration
Statement and are a part hereof from the date of filing such documents.
Any statement contained in a
document incorporated by reference or deemed to be incorporated by reference in
this Registration Statement shall be deemed to be modified or superseded for
purposes of this Registration Statement to the extent that a statement contained
in this Registration Statement or in any other subsequently filed document that
is also deemed to be incorporated by reference in this Registration Statement
modifies or supersedes the statement. Any such statement so modified or
superseded shall not be deemed, except as so modified or superseded, to
constitute a part of this Registration Statement.
ITEM 4 Description of Securities.
Not applicable.
ITEM 5. Interests of Named Experts and Counsel.
None.
ITEM 6. Indemnification of Directors and Officers.
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Reference is made to Section
102(b)(7) of the Delaware General Corporation Law (the "DGCL"), which enables a
corporation in its original certificate of incorporation or an amendment thereto
to eliminate or limit the personal liability of a director for violations of the
director's fiduciary duty, except (i) for any breach of the director's duty of
loyalty to the corporation or its stockholders, (ii) for acts or omissions not
in good faith or which involve intentional misconduct or a knowing violation of
law, (iii) pursuant to Section 174 of the DGCL (providing for liability of
directors for unlawful payment of dividends or unlawful stock purchases or
redemptions) or (iv) for any transaction from which a director derived an
improper personal benefit.
Paragraph 10 of the Registrant's
Certificate of Incorporation provides that, to the extent permitted by the DGCL
(or any statute succeeding such law), as such law now exists or may hereafter be
amended, no director of the Corporation shall be personally liable to the
Corporation or its stockholders for monetary damages for any breach of fiduciary
duty as a director during the time that Paragraph 10 is in effect.
Reference is also made to Section
145 of the DGCL, which provides that a corporation may indemnify any persons,
including officers and directors, who are, or are threatened to be made, parties
to any threatened, pending or completed legal action, suit or proceeding,
whether civil, criminal, administrative or investigative (other than an action
by or in the right of such corporation), by reason of the fact that such person
was an officer, director, employee or agent of such corporation, or is or was
serving at the request of such corporation as a officer, director, employee or
agent of another corporation or enterprise. The indemnity may include expenses
(including attorneys' fees), judgments, fines and amounts paid in settlement
actually and reasonably incurred by such person in connection with such action,
suit or proceeding, provided such officer, director, employee or agent acted in
good faith and in a manner he or she reasonably believed to be in or not opposed
to the corporation's best interests and, for criminal proceedings, had no
reasonable cause to believe that his or her conduct was unlawful. A Delaware
corporation may indemnify officers and directors in an action by or in the right
of the corporation under the same conditions, except that no indemnification is
permitted without judicial approval if the officer or director is a adjudged to
be liable to the corporation. Where an officer or director is successful on the
merits or otherwise in the defense of any action referred to above, the
corporation must indemnify him or her against the expenses which such officer or
director actually and reasonably incurred.
The Bylaws of the Registrant
provide for indemnification of officers and directors, including indemnification
for expenses, to the fullest extent permitted by applicable law.
The Registrant may enter into
contracts with its officers and directors requiring the Registrant to indemnify
them and to advance litigation expenses to them to the fullest extent permitted
by applicable law. Delaware law presently permits a Delaware corporation (i) to
indemnify any officer or director in any third party or governmental actions
against them for expenses, judgments, fines and amounts paid in settlement and,
in derivative actions, for expenses, if the indemnitee acted in good faith and
in a manner he or she believed to be in or not opposed to the best interests of
such corporation, and (ii) to advance expenses in any action provided that the
officer or director agrees to reimburse the corporation if it is ultimately
determined that he or she was not entitled to indemnification. Such contracts
may require the Registrant to (i) indemnify such officers and directors upon
receipt of an opinion of counsel in certain cases, (ii) pay indemnitee demands
pending a determination of entitlement thereto, and (iii) demonstrate, in any
action brought thereunder, that such officer or director was not entitled to
indemnification under applicable law.
3
Under the DGCL, the Board of
Directors may authorize, by a vote of the majority of a quorum of the Board of
Directors, the Registrant to purchase and maintain insurance on behalf of any
person who is or was a director, officer, employee or agent of the Registrant,
or is or was serving at the request of the Registrant as a director, officer,
employee or agent of another corporation, partnership, joint venture, trust or
other enterprise, against any liability asserted against him or her and incurred
by him or her in any such capacity, or arising out of his or her status as such,
whether or not the Registrant would have the power to indemnify him or her
against such liability under the Bylaws.
ITEM 7. Exemption from Registration Claimed.
Not applicable.
ITEM 8. Exhibits.
4.1
Minrad International, Inc. 2004 Stock Option
    Plan - incorporated by reference to Appendix C to the Registrant's
    definitive Information Statement, as filed with the SEC on September 16,
    2004.
4.2
Minrad International, Inc., Director
    Compensation Plan -- incorporated by reference to Appendix B to the
    Registrant's definitive proxy statement filed with the SEC on April 6, 2005.
5.
Opinion of Hodgson Russ LLP as to legality
    of securities being registered - filed herewith.
23.
(a) Consent of Hodgson Russ LLP -
    contained in Exhibit 5, filed herewith.
(b) Consent of Freed Maxick & Battaglia,
    CPAs, PC - filed herewith.
ITEM 9. Undertakings.
(a) The undersigned Registrant
hereby undertakes:
(1) To file, during any period in which offers or sales are being made, a
post-effective amendment to this registration statement:
(i) to include any prospectus required by section 10(a)(3) of the Securities Act
of 1933;
(ii) to reflect in the prospectus any facts or events arising after the
effective date of the registration statement (or the most recent post-effective
amendment thereof) which, individually or in the aggregate, represent a
fundamental change in the information set forth in the registration statement.
Notwithstanding the foregoing, any increase or decrease in volume of securities
offered (if the total dollar value of securities offered would not exceed that
which was registered) and any deviation from the low or high end of the
estimated maximum offering range may be reflected in the form of prospectus
filed with the Commission pursuant to Rule 424(b) (Regulation 230.424(b) of the
Commission) if, in the aggregate, the changes in volume and price represent no
more than a 20% change in the maximum aggregate offering price set forth in the
"Calculation of Registration Fee" table in the effective registration statement;
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(iii) to include any material information with respect to the plan of
distribution not previously disclosed in the registration statement or any
material change to such information in the registration statement; provided,
however, that paragraphs (a)(1)(i) and (a)(1)(ii) do not apply if the
registration statement is on Form S-3 or Form S-8, and the information required
to be included in a post-effective amendment by those paragraphs is contained in
periodic reports filed by the Registrant pursuant to Section 13 or Section 15(d)
of the Securities Exchange Act of 1934 that are incorporated by reference in the
registration statement;
(2) That, for the purpose of determining any liability under the Securities Act
of 1933, each post-effective amendment shall be deemed to be a new registration
statement relating to the securities offered therein, and the offering of such
securities at that time shall be deemed to be the initial bona fide offering
thereof; and
(3) To remove from registration by means of a post-effective amendment any of
the securities being registered which remain unsold at the termination of the
offering.
(b) The undersigned Registrant
hereby undertakes that, for purposes of determining any liability under the
Securities Act of 1933, each filing of the Registrant's annual report pursuant
to Section 13(a) or Section 15(d) of the Securities Exchange Act of 1934 that is
incorporated by reference in the registration statement shall be deemed to be a
new registration statement relating to the securities offered therein, and the
offering of such securities at that time shall be deemed to be the initial bona
fide offering thereof.
(c) The undersigned registrant
hereby undertakes to deliver or cause to be delivered with the prospectus, to
each person to whom the prospectus is sent or given, the latest annual report to
security holders that is incorporated by reference in the prospectus and
furnished pursuant to and meeting the requirements of Rule 14a-3 or Rule 14c-3
under the Securities Exchange Act of 1934; and, where interim financial
information required to be presented by Article 3 of Regulations S-X is not set
forth in the prospectus, to deliver, or cause to be delivered to each person to
whom the prospectus is sent or given, the latest quarterly report that is
specifically incorporated by reference in the prospectus to provide such interim
financial information.
(d) Insofar as indemnification for
liabilities arising under the Securities Act of 1933 may be permitted to
directors, officers and controlling persons of the Registrant pursuant to the
foregoing provisions, or otherwise, the Registrant has been advised that in the
opinion of the Securities and Exchange Commission such indemnification is
against public policy as expressed in such Act and is, therefore, unenforceable.
In the event that a claim for indemnification against such liabilities (other
than the payment by the Registrant of expenses incurred or paid by a director,
officer or controlling person of the Registrant in the successful defense of any
action, suit or proceeding) is asserted by such director, officer or controlling
person in connection with the securities being registered, the Registrant will,
unless in the opinion of its counsel the matter has been settled by controlling
precedent, submit to a court of appropriate jurisdiction the question whether
such indemnification by it is against public policy as expressed in the Act and
will be governed by the final adjudication of such issue.
[Remainder of Page Intentionally Left Blank]
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SIGNATURES
Pursuant to the requirements of
the Securities Act of 1933, the Registrant certifies that it has reasonable
grounds to believe that it meets all of the requirements for filing on Form S-8
and has duly caused this registration statement to be signed on its behalf by
the undersigned, thereunto duly authorized, in the City of Buffalo, State of New
York, on April 21, 2005.
MINRAD INTERNATIONAL, INC.
BY:
/S/ William H. Burns, Jr.
William H. Burns, Jr.
Chairman, President and Chief Executive Officer
Pursuant to the
requirements of the Securities Act of 1933, this registration statement has been
signed by the following persons in the capacities and on the dates indicated.
Signature
Title
Date
(a) Principal Executive
    Officer
/S/ William H. Burns, Jr.
Chairman, Chief
    Executive Officer and Director
April 21, 2005
William H. Burns, Jr.
(b) Principal Financial
    Officer
/S/ Richard Tamulski
Vice President
    and Chief Financial Officer
April 21, 2005
Richard Tamulski
(c) Principal Accounting
    Officer
/S/ William Rolfe
Controller
April 21, 2005
William Rolfe
(c) Directors
/S/ William H. Burns, Jr.
April 21, 2005
William H. Burns, Jr.
/S/ David DiGiacinto
David DiGiacinto
April 21, 2005
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/S/ David Donaldson
David Donaldson
April 21, 2005
/S/ Donald F. Farley
Donald F. Farley
April 21, 2005
/S/ Duane Hopper
Duane Hopper
April 21, 2005
/S/ Robert Lifeso
Robert Lifeso
April 21, 2005
/S/ John Rousseau
John Rousseau
April 21, 2005
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EXHIBIT INDEX
Exhibit No.
Description
Page or
Reference
4.1
Minrad
    International, Inc. 2004
Stock Option Plan
(1)
4.2
Minrad
    International, Inc. 2005 Director
Compensation Plan
(2)
5
Opinion of
    Hodgson Russ LLP as to
legality of
    securities being registered
Page 9
23 (a)
Consent of
    Hodgson Russ LLP (included in Exhibit No. 5)
Page 9
23 (b)
Consent of Freed
    Maxick & Battaglia, CPAs, PC
Page 10
(1)
Filed as Appendix C to the
    Registrant's definitive Information Statement filed with the SEC on
    September 16, 2004 and incorporated herein by reference.
(2)
Filed as Appendix
    B to the Registrant's definitive Proxy Statement filed with the SEC on April
    6, 2005.
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