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<p style="margin-bottom:0pt;margin-top:0pt;text-indent:0%;font-family:Times New Roman;font-size:10pt;">&nbsp;</p>
<p style="text-align:center;margin-bottom:0pt;margin-top:0pt;text-indent:0%;font-weight:bold;font-size:8pt;font-family:Times New Roman;font-style:normal;text-transform:none;font-variant: normal;">AS FILED WITH THE SECURITIES AND EXCHANGE COMMISSION ON MAY 10, 2019</p>
<p style="text-align:center;margin-bottom:0pt;margin-top:0pt;text-indent:0%;font-weight:bold;font-size:8pt;font-family:Times New Roman;font-style:normal;text-transform:none;font-variant: normal;">&nbsp;</p>
<p style="text-align:right;margin-bottom:0pt;margin-top:0pt;text-indent:0%;font-weight:bold;font-size:8pt;font-family:Times New Roman;font-style:normal;text-transform:none;font-variant: normal;">REGISTRATION NO. 333-&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;</p>
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<p style="margin-bottom:0pt;margin-top:0pt;text-indent:0%;font-weight:bold;;font-size:6pt;">&nbsp;</p>
<p style="margin-bottom:6pt;margin-top:0pt;text-align:center;text-indent:0%;font-size:16pt;font-weight:bold;font-style:normal;letter-spacing:-0.1pt;font-family:Times New Roman;text-transform:none;font-variant: normal;"><font style="text-decoration:none;">UNITED STATES<br />SECURITIES AND EXCHANGE COMMISSION<br /></font><font style="font-size:12pt;text-decoration:none;">Washington, D.C. 20549 </font></p>
<p style="margin-bottom:3pt;margin-top:0pt;text-align:center;text-indent:0%;font-weight:bold;font-style:normal;font-size:10pt;letter-spacing:-0.1pt;font-family:Times New Roman;text-transform:none;font-variant: normal;"><font style="text-decoration:none;">____________________</font></p>
<p style="margin-bottom:6pt;margin-top:0pt;text-align:center;text-indent:0%;font-size:16pt;font-weight:bold;font-style:normal;letter-spacing:-0.1pt;font-family:Times New Roman;text-transform:none;font-variant: normal;"><font style="text-decoration:none;">FORM S-8<br />REGISTRATION STATEMENT </font></p>
<p style="margin-bottom:6pt;margin-top:0pt;text-align:center;text-indent:0%;font-size:12pt;font-weight:bold;font-style:normal;letter-spacing:-0.1pt;font-family:Times New Roman;text-transform:none;font-variant: normal;"><font style="text-decoration:none;">UNDER<br />THE SECURITIES ACT OF 1933</font></p>
<p style="margin-bottom:3pt;margin-top:0pt;text-align:center;text-indent:0%;font-weight:bold;font-style:normal;font-size:10pt;letter-spacing:-0.1pt;font-family:Times New Roman;text-transform:none;font-variant: normal;"><font style="text-decoration:none;">____________________</font></p>
<p style="margin-bottom:6pt;margin-top:0pt;text-align:center;text-indent:0%;font-size:22pt;font-weight:bold;font-style:normal;letter-spacing:-0.1pt;font-family:Times New Roman;text-transform:none;font-variant: normal;"><font style="text-decoration:none;">ENANTA PHARMACEUTICALS, INC.<br /></font><font style="font-size:8pt;text-decoration:none;">(Exact name of registrant as specified in its charter)</font><font style="font-weight:normal;font-size:8pt;text-decoration:none;"> </font></p>
<p style="margin-bottom:3pt;margin-top:0pt;text-align:center;text-indent:0%;font-weight:bold;font-style:normal;font-size:10pt;letter-spacing:-0.1pt;font-family:Times New Roman;text-transform:none;font-variant: normal;"><font style="text-decoration:none;">____________________</font></p>
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<p style="text-align:center;margin-bottom:0pt;margin-top:0pt;margin-left:0pt;;text-indent:0pt;;font-weight:bold;font-family:Times New Roman;font-size:10pt;font-style:normal;text-transform:none;font-variant: normal;">Delaware</p></td>
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<p style="text-align:center;margin-bottom:0pt;margin-top:0pt;margin-left:0pt;;text-indent:0pt;;font-weight:bold;font-family:Times New Roman;font-size:10pt;font-style:normal;text-transform:none;font-variant: normal;">04-3205099</p></td>
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<p style="text-align:center;margin-bottom:6pt;margin-top:0pt;margin-left:0pt;;text-indent:0pt;;font-size:8pt;font-family:Times New Roman;font-weight:normal;font-style:normal;text-transform:none;font-variant: normal;">(State or other jurisdiction of incorporation or organization)</p></td>
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<p style="text-align:center;margin-bottom:6pt;margin-top:0pt;margin-left:0pt;;text-indent:0pt;;font-size:8pt;font-family:Times New Roman;font-weight:normal;font-style:normal;text-transform:none;font-variant: normal;">(I.R.S. Employer Identification No.)</p></td>
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<p style="text-align:center;margin-bottom:0pt;margin-top:0pt;margin-left:0pt;;text-indent:0pt;;font-weight:bold;letter-spacing:-0.1pt;font-family:Times New Roman;font-size:10pt;font-style:normal;text-transform:none;font-variant: normal;">500 Arsenal Street, Watertown, MA</p>
<p style="text-align:center;margin-bottom:6pt;margin-top:0pt;margin-left:0pt;;text-indent:0pt;;font-size:8pt;font-family:Times New Roman;font-weight:normal;font-style:normal;text-transform:none;font-variant: normal;">(Address of Principal Executive Offices)</p></td>
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<p style="text-align:center;margin-bottom:0pt;margin-top:0pt;margin-left:0pt;;text-indent:0pt;;font-weight:bold;letter-spacing:-0.1pt;font-family:Times New Roman;font-size:10pt;font-style:normal;text-transform:none;font-variant: normal;">02472</p>
<p style="text-align:center;margin-bottom:6pt;margin-top:0pt;margin-left:0pt;;text-indent:0pt;;font-size:8pt;letter-spacing:-0.1pt;font-family:Times New Roman;font-weight:normal;font-style:normal;text-transform:none;font-variant: normal;">(Zip Code)</p></td>
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<p style="margin-bottom:6pt;margin-top:0pt;text-align:center;text-indent:0%;font-size:10pt;font-family:Times New Roman;font-weight:bold;">&nbsp;</p>
<p style="margin-bottom:6pt;margin-top:0pt;text-align:center;text-indent:0%;font-weight:bold;font-style:normal;font-size:10pt;letter-spacing:-0.1pt;font-family:Times New Roman;text-transform:none;font-variant: normal;"><font style="text-decoration:none;">2012 Equity Incentive Plan<br /></font><font style="font-weight:normal;font-size:8pt;text-decoration:none;">(Full title of the plan)</font></p>
<p style="margin-bottom:3pt;margin-top:0pt;text-align:center;text-indent:0%;font-weight:bold;font-style:normal;font-size:10pt;letter-spacing:-0.1pt;font-family:Times New Roman;text-transform:none;font-variant: normal;"><font style="text-decoration:none;">____________________</font></p>
<p style="margin-bottom:6pt;margin-top:0pt;text-align:center;text-indent:0%;font-weight:bold;font-style:normal;font-size:10pt;letter-spacing:-0.1pt;font-family:Times New Roman;text-transform:none;font-variant: normal;"><font style="text-decoration:none;">Jay R. Luly<br />President and Chief Executive Officer<br />Enanta Pharmaceuticals, Inc.<br />500 Arsenal Street<br />Watertown, Massachusetts 02472<br /></font><font style="font-weight:normal;font-size:8pt;text-decoration:none;"> (Name and address of agent for service) </font></p>
<p style="margin-bottom:6pt;margin-top:0pt;text-align:center;text-indent:0%;font-weight:bold;font-style:normal;font-size:10pt;letter-spacing:-0.1pt;font-family:Times New Roman;text-transform:none;font-variant: normal;"><font style="text-decoration:none;">(617)&#160;607-0800</font><font style="font-weight:normal;text-decoration:none;"><br /></font><font style="font-weight:normal;font-size:8pt;text-decoration:none;">(Telephone number, including area code, of agent for service)</font></p>
<p style="margin-bottom:3pt;margin-top:0pt;text-align:center;text-indent:0%;font-weight:bold;font-style:normal;font-size:10pt;letter-spacing:-0.1pt;font-family:Times New Roman;text-transform:none;font-variant: normal;"><font style="text-decoration:none;">____________________</font></p>
<p style="margin-bottom:6pt;margin-top:0pt;text-align:center;text-indent:0%;font-style:italic;font-weight:bold;font-size:10pt;letter-spacing:-0.1pt;font-family:Times New Roman;text-transform:none;font-variant: normal;"><font style="text-decoration:none;">Copy to: </font></p>
<p style="margin-bottom:0pt;margin-top:0pt;text-align:center;text-indent:0%;font-weight:bold;font-style:normal;font-size:10pt;letter-spacing:-0.1pt;font-family:Times New Roman;text-transform:none;font-variant: normal;"><font style="text-decoration:none;">Stacie S. Aarestad, Esq.<br />Foley Hoag LLP</font></p>
<p style="margin-bottom:0pt;margin-top:0pt;text-align:center;text-indent:0%;font-weight:bold;font-style:normal;font-size:10pt;letter-spacing:-0.1pt;font-family:Times New Roman;text-transform:none;font-variant: normal;"><font style="text-decoration:none;">155 Seaport Boulevard<br />Boston, Massachusetts 02110-2600<br />(617)&#160;832-1000 </font></p>
<p style="margin-bottom:3pt;margin-top:0pt;text-align:center;text-indent:0%;font-weight:bold;font-style:normal;font-size:10pt;letter-spacing:-0.1pt;font-family:Times New Roman;text-transform:none;font-variant: normal;"><font style="text-decoration:none;">____________________</font></p>
<p style="border-top:none 0pt;padding-top:1pt;border-left:none 0pt;padding-left:3pt;margin-bottom:0pt;margin-top:0pt;text-indent:0%;font-size:9pt;font-family:Times New Roman;font-weight:normal;font-style:normal;text-transform:none;font-variant: normal;">Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, a non&#8209;accelerated filer, a smaller reporting company or an emerging growth company. See the definitions of &#8220;large accelerated filer,&#8221; &#8220;accelerated filer,&#8221; &#8220;smaller reporting company&#8221; and &#8220;emerging growth company&#8221; in Rule&#160;12b&#8209;2 of the Exchange Act.</p>
<p style="Background-color:#auto;margin-bottom:0pt;margin-top:0pt;text-indent:0%;font-size:2pt;font-family:Times New Roman;font-weight:normal;font-style:normal;text-transform:none;font-variant: normal;">&#160;</p>
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<td valign="bottom"  style="width:25.18%;">
<p style="Background-color:#auto;margin-bottom:0pt;margin-top:0pt;margin-left:0pt;;text-indent:0pt;;font-size:9pt;font-family:Times New Roman;font-weight:normal;font-style:normal;text-transform:none;font-variant: normal;">Large&#160;accelerated&#160;filer</p></td>
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<p style="Background-color:#auto;margin-bottom:0pt;margin-top:0pt;margin-left:0pt;;text-indent:0pt;;font-size:9pt;font-weight:normal;font-style:normal;text-transform:none;font-variant: normal;font-family:'Times New Roman';"><font style="font-size:9pt;font-family:'Times New Roman'">&#9746;</font></p></td>
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<p style="Background-color:#auto;margin-bottom:0pt;margin-top:0pt;margin-left:0pt;;text-indent:0pt;;font-size:9pt;font-family:Times New Roman;font-weight:normal;font-style:normal;text-transform:none;font-variant: normal;">Accelerated&#160;filer</p></td>
<td valign="bottom"  style="width:1.66%;">
<p style="Background-color:#auto;margin-bottom:0pt;margin-top:0pt;margin-left:0pt;;text-indent:0pt;;font-size:9pt;font-weight:normal;font-style:normal;text-transform:none;font-variant: normal;font-family:'Times New Roman';"><font style="font-size:9pt;font-family:'Times New Roman'">&#9744;</font></p></td>
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<p style="Background-color:#auto;margin-bottom:0pt;margin-top:0pt;margin-left:0pt;;text-indent:0pt;;font-size:9pt;">&nbsp;</p></td>
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<p style="Background-color:#auto;margin-bottom:0pt;margin-top:0pt;margin-left:0pt;;text-indent:0pt;;font-size:9pt;">&nbsp;</p></td>
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<p style="Background-color:#auto;margin-bottom:0pt;margin-top:0pt;margin-left:0pt;;text-indent:0pt;;font-size:9pt;">&nbsp;</p></td>
<td valign="middle"  style="width:1.66%;">
<p style="Background-color:#auto;margin-bottom:0pt;margin-top:0pt;margin-left:0pt;;text-indent:0pt;;font-size:9pt;">&nbsp;</p></td>
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<tr style="height:1pt;">
<td valign="bottom"  style="width:25.18%;">
<p style="Background-color:#auto;margin-bottom:0pt;margin-top:0pt;margin-left:0pt;;text-indent:0pt;;font-size:9pt;font-family:Times New Roman;font-weight:normal;font-style:normal;text-transform:none;font-variant: normal;">Non-accelerated filer</p></td>
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<p style="Background-color:#auto;margin-bottom:0pt;margin-top:0pt;margin-left:0pt;;text-indent:0pt;;font-size:9pt;font-weight:normal;font-style:normal;text-transform:none;font-variant: normal;font-family:'Times New Roman';"><font style="font-size:9pt;font-family:'Times New Roman'">&#9744;</font><font style="font-family:Times New Roman;">&#160;&#160;</font></p></td>
<td valign="bottom"  style="width:20.6%;">
<p style="Background-color:#auto;margin-bottom:0pt;margin-top:0pt;margin-left:0pt;;text-indent:0pt;;font-size:9pt;font-family:Times New Roman;font-weight:normal;font-style:normal;text-transform:none;font-variant: normal;">Smaller&#160;reporting&#160;company</p></td>
<td valign="bottom"  style="width:1.66%;">
<p style="Background-color:#auto;margin-bottom:0pt;margin-top:0pt;margin-left:0pt;;text-indent:0pt;;font-size:9pt;font-weight:normal;font-style:normal;text-transform:none;font-variant: normal;font-family:'Times New Roman';"><font style="font-size:9pt;font-family:'Times New Roman'">&#9744;</font></p></td>
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<tr style="height:1pt;">
<td valign="bottom"  style="width:25.18%;">
<p style="Background-color:#auto;margin-bottom:0pt;margin-top:0pt;margin-left:0pt;;text-indent:0pt;;font-size:9pt;font-family:Times New Roman;font-weight:normal;font-style:normal;text-transform:none;font-variant: normal;">Emerging growth company </p></td>
<td valign="bottom"  style="width:52.58%;">
<p style="Background-color:#auto;margin-bottom:0pt;margin-top:0pt;margin-left:0pt;;text-indent:0pt;;font-size:9pt;font-weight:normal;font-style:normal;text-transform:none;font-variant: normal;font-family:'Times New Roman';"><font style="font-size:9pt;font-family:'Times New Roman'">&#9744;</font></p></td>
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<p style="Background-color:#auto;margin-bottom:0pt;margin-top:0pt;margin-left:0pt;;text-indent:0pt;;font-size:9pt;">&nbsp;</p></td>
<td valign="bottom"  style="width:1.66%;">
<p style="Background-color:#auto;margin-bottom:0pt;margin-top:0pt;margin-left:0pt;;text-indent:0pt;;font-size:9pt;">&nbsp;</p></td>
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<p style="margin-top:12pt;line-height:10pt;margin-bottom:0pt;margin-left:0pt;;text-indent:0pt;;font-family:Times New Roman;font-size:10pt;">&nbsp;</p>
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<p style="margin-bottom:0pt;margin-top:0pt;margin-left:0pt;;text-indent:0pt;;font-family:Times New Roman;font-size:10pt;">&nbsp;</p>
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<table border="0" cellspacing="0" cellpadding="0" align="center" style="border-collapse:collapse; width:98.38%;">
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<td colspan="3" valign="top"  style="width:98.34%;">
<p style="Background-color:#auto;margin-bottom:0pt;margin-top:0pt;margin-left:0pt;;text-indent:0pt;;font-size:9pt;">&nbsp;</p>
<p style="Background-color:#auto;margin-bottom:0pt;margin-top:0pt;margin-left:0pt;;text-indent:0pt;;font-size:9pt;font-family:Times New Roman;font-weight:normal;font-style:normal;text-transform:none;font-variant: normal;"><a name="_AEIOULastRenderedPageBreakAEIOU2"></a><font style="font-size:9pt;font-family:Times New Roman;font-weight:normal;font-style:normal;text-transform:none;font-variant: normal;">If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards </font><font style="font-size:9pt;font-family:Times New Roman;font-weight:normal;font-style:normal;text-transform:none;font-variant: normal;">provided pursuant to Section 7(a)(2)(B) of the Securities Act.</font></p></td>
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<p style="Background-color:#auto;margin-bottom:0pt;margin-top:0pt;margin-left:0pt;;text-indent:0pt;;font-size:9pt;">&nbsp;</p>
<p style="Background-color:#auto;margin-bottom:0pt;margin-top:0pt;margin-left:0pt;;text-indent:0pt;;font-size:9pt;font-weight:normal;font-style:normal;text-transform:none;font-variant: normal;font-family:'Times New Roman';"><a name="_AEIOULastRenderedPageBreakAEIOU3"></a><font style="font-size:9pt;font-family:'Times New Roman'">&#9744;</font></p></td>
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<p style="Background-color:#auto;margin-bottom:0pt;margin-top:0pt;margin-left:0pt;;text-indent:0pt;;font-size:9pt;">&nbsp;</p></td>
<td valign="bottom"  style="width:1.66%;">
<p style="Background-color:#auto;margin-bottom:0pt;margin-top:0pt;margin-left:0pt;;text-indent:0pt;;font-size:9pt;">&nbsp;</p></td>
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<p style="margin-bottom:3pt;margin-top:0pt;text-indent:2.02%;font-size:9pt;font-family:Times New Roman;font-weight:normal;font-style:normal;text-transform:none;font-variant: normal;">&nbsp;</p>
<p style="text-align:center;margin-bottom:6pt;margin-top:0pt;text-indent:0%;font-weight:bold;font-family:Times New Roman;font-size:10pt;font-style:normal;text-transform:none;font-variant: normal;">CALCULATION OF REGISTRATION FEE</p>
<div>
<table border="0" cellspacing="0" cellpadding="0" align="center" style="border-collapse:collapse; width:102.82%;">
<tr style="height:1pt;">
<td valign="bottom"  style="width:22.14%; border-top:solid 0.75pt #000000; border-bottom:solid 0.75pt #000000; border-left:solid 0.75pt #000000; border-right:solid 0.75pt #000000;">
<p style="text-align:center;Background-color:#auto;margin-bottom:0pt;margin-top:0pt;margin-left:0pt;;text-indent:0pt;;font-family:Times New Roman;font-size:10pt;font-weight:normal;font-style:normal;text-transform:none;font-variant: normal;">Title of each class of securities to be registered</p></td>
<td valign="bottom"  style="width:16.72%; border-top:solid 0.75pt #000000; border-bottom:solid 0.75pt #000000; border-left:solid 0.75pt #000000; border-right:solid 0.75pt #000000;">
<p style="text-align:center;Background-color:#auto;margin-bottom:0pt;margin-top:0pt;margin-left:0pt;;text-indent:0pt;;font-family:Times New Roman;font-size:10pt;font-weight:normal;font-style:normal;text-transform:none;font-variant: normal;">Amount to be registered(1)</p></td>
<td valign="bottom"  style="width:19.44%; border-top:solid 0.75pt #000000; border-bottom:solid 0.75pt #000000; border-left:solid 0.75pt #000000; border-right:solid 0.75pt #000000;">
<p style="text-align:center;Background-color:#auto;margin-bottom:0pt;margin-top:0pt;margin-left:0pt;;text-indent:0pt;;font-family:Times New Roman;font-size:10pt;font-weight:normal;font-style:normal;text-transform:none;font-variant: normal;">Proposed maximum offering price</p>
<p style="text-align:center;Background-color:#auto;margin-bottom:0pt;margin-top:0pt;margin-left:0pt;;text-indent:0pt;;font-family:Times New Roman;font-size:10pt;font-weight:normal;font-style:normal;text-transform:none;font-variant: normal;">per share(2)</p></td>
<td valign="bottom"  style="width:19.48%; border-top:solid 0.75pt #000000; border-bottom:solid 0.75pt #000000; border-left:solid 0.75pt #000000; border-right:solid 0.75pt #000000;">
<p style="text-align:center;margin-bottom:2pt;margin-top:0pt;margin-left:0pt;;text-indent:0pt;;font-family:Times New Roman;font-size:10pt;font-weight:normal;font-style:normal;text-transform:none;font-variant: normal;">Proposed maximum aggregate offering</p>
<p style="text-align:center;margin-bottom:2pt;margin-top:0pt;margin-left:0pt;;text-indent:0pt;;font-family:Times New Roman;font-size:10pt;font-weight:normal;font-style:normal;text-transform:none;font-variant: normal;">price(3)</p></td>
<td valign="bottom"  style="width:22.22%; border-top:solid 0.75pt #000000; border-bottom:solid 0.75pt #000000; border-left:solid 0.75pt #000000; border-right:solid 0.75pt #000000;">
<p style="text-align:center;margin-bottom:2pt;margin-top:0pt;margin-left:0pt;;text-indent:0pt;;font-family:Times New Roman;font-size:10pt;font-weight:normal;font-style:normal;text-transform:none;font-variant: normal;">Amount of registration fee</p></td>
</tr>
<tr style="height:1pt;">
<td valign="bottom"  style="width:22.14%; border-top:solid 0.75pt #000000; border-bottom:solid 0.75pt #000000; border-left:solid 0.75pt #000000; border-right:solid 0.75pt #000000;">
<p style="text-align:center;margin-bottom:6pt;margin-top:6pt;margin-left:0pt;;text-indent:0pt;;font-family:Times New Roman;font-size:10pt;font-weight:normal;font-style:normal;text-transform:none;font-variant: normal;">Common Stock, $0.01 par value</p></td>
<td valign="bottom"  style="width:16.72%; border-top:solid 0.75pt #000000; border-bottom:solid 0.75pt #000000; border-left:solid 0.75pt #000000; border-right:solid 0.75pt #000000;">
<p style="text-align:center;margin-bottom:6pt;margin-top:6pt;margin-left:0pt;;text-indent:0pt;;font-family:Times New Roman;font-size:10pt;font-weight:normal;font-style:normal;text-transform:none;font-variant: normal;">241,826 shares </p></td>
<td valign="bottom"  style="width:19.44%; border-top:solid 0.75pt #000000; border-bottom:solid 0.75pt #000000; border-left:solid 0.75pt #000000; border-right:solid 0.75pt #000000;">
<p style="text-align:center;margin-bottom:6pt;margin-top:6pt;margin-left:0pt;;text-indent:0pt;;font-family:Times New Roman;font-size:10pt;font-weight:normal;font-style:normal;text-transform:none;font-variant: normal;">$78.39</p></td>
<td valign="bottom"  style="width:19.48%; border-top:solid 0.75pt #000000; border-bottom:solid 0.75pt #000000; border-left:solid 0.75pt #000000; border-right:solid 0.75pt #000000;">
<p style="text-align:center;margin-bottom:6pt;margin-top:6pt;margin-left:0pt;;text-indent:0pt;;font-family:Times New Roman;font-size:10pt;font-weight:normal;font-style:normal;text-transform:none;font-variant: normal;">$18,956,740.14</p></td>
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<p style="text-align:center;margin-bottom:6pt;margin-top:6pt;margin-left:0pt;;text-indent:0pt;;font-family:Times New Roman;font-size:10pt;font-weight:normal;font-style:normal;text-transform:none;font-variant: normal;">$2,297.56</p></td>
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<p style="margin-bottom:0pt;margin-top:6pt;font-weight:normal;font-style:normal;text-transform:none;font-variant: normal;font-family:Times New Roman;font-size:10pt;">&nbsp;</p></td>
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<p style="margin-bottom:0pt;margin-top:6pt;font-family:Times New Roman;font-size:10pt;font-weight:normal;font-style:normal;text-transform:none;font-variant: normal;"><font style="font-family:Times New Roman;font-size:10pt;font-weight:normal;font-style:normal;text-transform:none;font-variant: normal;">(1)</font></p></td>
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<p style="margin-bottom:0pt;margin-top:6pt;font-weight:normal;font-style:normal;text-transform:none;font-variant: normal;font-family:Times New Roman;font-size:10pt;">This Registration Statement covers an aggregate of 241,826 shares of the Registrant&#8217;s Common Stock, par value $0.01 per share (the &#8220;Common Stock&#8221;), that are issuable with respect to outstanding options previously granted under the Registrant&#8217;s 2012 Equity Incentive Plan (the &#8220;2012 Plan&#8221;). In addition, pursuant to Rule 416(a) under the Securities Act of 1933, as amended (the &#8220;Securities Act&#8221;) this Registration Statement also covers such additional shares of Common Stock as may be issued to prevent dilution from stock splits, stock dividends and similar transactions.</p></td></tr></table></div>
<p style="margin-bottom:0pt;margin-top:0pt;margin-left:7.27%;text-indent:0%;font-family:Times New Roman;font-size:10pt;">&nbsp;</p>
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<p style="margin-bottom:0pt;margin-top:0pt;font-weight:normal;font-style:normal;text-transform:none;font-variant: normal;font-family:Times New Roman;font-size:10pt;">&nbsp;</p></td>
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<p style="margin-bottom:0pt;margin-top:0pt;font-family:Times New Roman;font-size:10pt;font-weight:normal;font-style:normal;text-transform:none;font-variant: normal;"><font style="font-family:Times New Roman;font-size:10pt;font-weight:normal;font-style:normal;text-transform:none;font-variant: normal;">(2)</font></p></td>
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<p style="margin-bottom:0pt;margin-top:0pt;font-weight:normal;font-style:normal;text-transform:none;font-variant: normal;font-family:Times New Roman;font-size:10pt;"><font style="color:#000000;">Estimated solely for the purpose of calculating the registration fee pursuant to paragraphs (c) and (h) of Rule 457 under the Securities Act. For the shares of common stock reserved for issuance upon the exercise of outstanding options previously granted pursuant to the 2012 Plan, the proposed maximum offering price is $78.39 per share, which is the weighted average exercise price (rounded to the nearest cent) of the outstanding awards under the 2012 Plan and the grant date fair value per share of common stock underlying outstanding performance share unit awards made under the 2012 Plan.</font></p></td></tr></table></div>
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<p style="margin-top:0pt;margin-bottom:0pt;font-weight:normal;font-style:normal;text-transform:none;font-variant: normal;font-family:Times New Roman;font-size:10pt;">&nbsp;</p></td>
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<p style="margin-top:0pt;margin-bottom:0pt;font-family:Times New Roman;font-size:10pt;font-weight:normal;font-style:normal;text-transform:none;font-variant: normal;"><font style="font-family:Times New Roman;font-size:10pt;font-weight:normal;font-style:normal;text-transform:none;font-variant: normal;">(3)</font></p></td>
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<p style="margin-top:0pt;margin-bottom:0pt;font-weight:normal;font-style:normal;text-transform:none;font-variant: normal;font-family:Times New Roman;font-size:10pt;"><font style="color:#000000;">Reflects the aggregate offering price based on the weighted average exercise price of the outstanding options and the grant date fair value of shares underlying outstanding performance share unit awards described in Note 2 above.</font></p></td></tr></table></div>
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<p style="margin-bottom:0pt;margin-top:0pt;text-indent:0%;font-family:Times New Roman;font-size:10pt;">&nbsp;</p>
<p style="text-align:center;margin-bottom:12pt;margin-top:0pt;text-indent:0%;font-weight:bold;font-family:Times New Roman Bold;text-transform:uppercase;font-size:10pt;font-style:normal;font-variant: normal;"><a name="_AEIOULastRenderedPageBreakAEIOU4"></a><font style="font-weight:bold;font-family:Times New Roman Bold;text-transform:uppercase;font-size:10pt;font-style:normal;font-variant: normal;">Statement Regarding Incorporation by Reference from Effective Registration Statement </font></p>
<p style="margin-bottom:12pt;margin-top:0pt;text-indent:7.34%;font-family:Times New Roman;font-size:10pt;font-weight:normal;font-style:normal;text-transform:none;font-variant: normal;">Pursuant to Instruction E to Form S-8, the Registrant incorporates by reference into this Registration Statement the entire contents of its Registration Statements on Form S-8 filed with the Securities and Exchange Commission on <a href="http://www.sec.gov/Archives/edgar/data/1177648/000119312513253471/d551465ds8.htm"><font style="text-decoration:underline;">June 10, 2013</font></a> (File No. 333-189217) , <a href="http://www.sec.gov/Archives/edgar/data/1177648/000119312513253471/d551465ds8.htm"><a href="http://www.sec.gov/Archives/edgar/data/1177648/000119312513477884/d646849ds8.htm"><font style="text-decoration:underline;">December 18, 2013</font></a> (File No. 333-192935), <a href="http://www.sec.gov/Archives/edgar/data/1177648/000119312513253471/d551465ds8.htm"><a href="http://www.sec.gov/Archives/edgar/data/1177648/000119312513477884/d646849ds8.htm"><a href="http://www.sec.gov/Archives/edgar/data/1177648/000119312515060129/d879227ds8.htm"><font style="text-decoration:underline;">February 24, 2015</font></a> (File No. 333- 202257), <a href="http://www.sec.gov/Archives/edgar/data/1177648/000119312513253471/d551465ds8.htm"><a href="http://www.sec.gov/Archives/edgar/data/1177648/000119312513477884/d646849ds8.htm"><a href="http://www.sec.gov/Archives/edgar/data/1177648/000119312515060129/d879227ds8.htm"><a href="http://www.sec.gov/Archives/edgar/data/1177648/000119312516465328/d16962ds8.htm"><font style="text-decoration:underline;">February 16, 2016</font></a> (File No. 333-209542), <a href="http://www.sec.gov/Archives/edgar/data/1177648/000119312513253471/d551465ds8.htm"><a href="http://www.sec.gov/Archives/edgar/data/1177648/000119312513477884/d646849ds8.htm"><a href="http://www.sec.gov/Archives/edgar/data/1177648/000119312515060129/d879227ds8.htm"><a href="http://www.sec.gov/Archives/edgar/data/1177648/000119312516465328/d16962ds8.htm"><a href="http://www.sec.gov/Archives/edgar/data/1177648/000119312516789668/d303350ds8.htm"><font style="text-decoration:underline;">December 9, 2016</font></a> (File No. 333-215011) and <a href="http://www.sec.gov/Archives/edgar/data/1177648/000119312513253471/d551465ds8.htm"><a href="http://www.sec.gov/Archives/edgar/data/1177648/000119312513477884/d646849ds8.htm"><a href="http://www.sec.gov/Archives/edgar/data/1177648/000119312515060129/d879227ds8.htm"><a href="http://www.sec.gov/Archives/edgar/data/1177648/000119312516465328/d16962ds8.htm"><a href="http://www.sec.gov/Archives/edgar/data/1177648/000119312516789668/d303350ds8.htm"><a href="http://www.sec.gov/Archives/edgar/data/1177648/000156459017024801/enta-s8.htm"><font style="text-decoration:underline;">December 11, 2017</font></a> (File No. 333-221988).</p>
<p style="margin-bottom:12pt;margin-top:0pt;text-indent:7.34%;font-family:Times New Roman;font-size:10pt;font-weight:normal;font-style:normal;text-transform:none;font-variant: normal;">The number of shares of Common Stock, $0.01 par value per share, of the Company available for issuance under the 2012 Plan was subject to an automatic annual increase on the first day of each fiscal year of the Company equal to the least of (i) 3% of the outstanding shares on such date, (ii) 2,088,167 shares of Common Stock, or (iii) an amount determined by the Board. This Registration Statement registers the 241,826 shares of Common Stock that are subject to outstanding option and performance share unit awards that were made following the automatic annual increase of 582,637 shares of Common Stock on October 1, 2018 and prior to the approval of the Registrant&#8217;s 2019 Equity Incentive Plan (the &#8220;2019 Plan&#8221;) at the Registrant&#8217;s annual stockholder meeting on February 28, 2019.&nbsp;&nbsp;The 340,811 shares of Common Stock that remained available for future issuance under the 2012 Plan immediately prior to stockholder approval of the 2019 Plan on February 28, 2019 became available for issuance under the 2019 Plan in accordance with its terms at such time. Those shares are being registered on a Registration Statement on Form S-8 being filed by the Registrant to register shares issuable under the 2019 Plan contemporaneously with the filing of this Registration Statement on Form S-8.&nbsp;&nbsp;</p>
<p style="text-align:center;margin-bottom:12pt;margin-top:0pt;text-indent:0%;font-weight:bold;font-family:Times New Roman;font-size:10pt;font-style:normal;text-transform:none;font-variant: normal;">Part II</p>
<p style="text-align:center;margin-bottom:12pt;margin-top:0pt;text-indent:-0.21%;font-weight:bold;font-family:Times New Roman;font-size:10pt;font-style:normal;text-transform:none;font-variant: normal;">INFORMATION REQUIRED IN THE REGISTRATION STATEMENT</p>
<p style="margin-bottom:12pt;margin-top:0pt;text-indent:0%;font-weight:bold;font-family:Times New Roman;font-size:10pt;font-style:normal;text-transform:none;font-variant: normal;">Item 8.&nbsp;&nbsp;Exhibits.</p>
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<p style="text-align:center;margin-bottom:12pt;margin-top:0pt;margin-left:0pt;;text-indent:0pt;;font-weight:bold;font-family:Times New Roman;font-size:10pt;font-style:normal;text-transform:none;font-variant: normal;">Exhibit<br /><font style="text-decoration:underline;">Number</font></p></td>
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<p style="margin-bottom:12pt;margin-top:0pt;margin-left:30.6pt;;text-indent:0pt;;font-weight:bold;font-family:Times New Roman;font-size:10pt;font-style:normal;text-transform:none;font-variant: normal;"><font style="text-decoration:underline;">Description</font></p></td>
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<p style="text-align:center;margin-bottom:12pt;margin-top:0pt;margin-left:0pt;;text-indent:0pt;;font-family:Times New Roman;font-size:10pt;font-weight:normal;font-style:normal;text-transform:none;font-variant: normal;">4.1</p></td>
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<p style="margin-bottom:12pt;margin-top:0pt;margin-left:0pt;;text-indent:0pt;;font-family:Times New Roman;font-size:10pt;font-weight:normal;font-style:normal;text-transform:none;font-variant: normal;"><a href="http://www.sec.gov/Archives/edgar/data/1177648/000119312513132679/d511662dex31.htm"><font style="text-decoration:underline;">Restated Certificate of Incorporation of Enanta Pharmaceuticals, Inc.&nbsp;&nbsp;Previously filed as Exhibit 3.1 to the Registrant&#8217;s Current Report on Form 8&#8209;K filed with the SEC on March 28, 2013 (File No.&#160;001-35839) and incorporated herein by reference</font>.</a></p></td>
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<p style="text-align:center;margin-bottom:12pt;margin-top:0pt;margin-left:0pt;;text-indent:0pt;;font-family:Times New Roman;font-size:10pt;font-weight:normal;font-style:normal;text-transform:none;font-variant: normal;">4.2</p></td>
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<p style="margin-bottom:12pt;margin-top:0pt;margin-left:0pt;;text-indent:0pt;;font-family:Times New Roman;font-size:10pt;font-weight:normal;font-style:normal;text-transform:none;font-variant: normal;"><a href="http://www.sec.gov/Archives/edgar/data/1177648/000119312515294582/d95810dex32.htm"><font style="text-decoration:underline;">Amended and Restated Bylaws of Enanta Pharmaceuticals, Inc. (as amended and restated in August 2015).&nbsp;&nbsp;Previously filed as Exhibit 3.2 to the Registrant&#8217;s Current Report on Form 8&#8209;K filed with the SEC on August 18, 2015 (File No.&#160;001-35839) and incorporated herein by reference.</font></a></p></td>
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<p style="text-align:center;margin-bottom:12pt;margin-top:0pt;margin-left:0pt;;text-indent:0pt;;font-family:Times New Roman;font-size:10pt;font-weight:normal;font-style:normal;text-transform:none;font-variant: normal;">4.3</p></td>
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<p style="margin-bottom:12pt;margin-top:0pt;margin-left:0pt;;text-indent:0pt;;font-family:Times New Roman;font-size:10pt;font-weight:normal;font-style:normal;text-transform:none;font-variant: normal;"><a href="http://www.sec.gov/Archives/edgar/data/1177648/000119312513038960/d401292dex41.htm"><font style="text-decoration:underline;">Specimen certificate evidencing shares of common stock of Enanta Pharmaceuticals, Inc.&nbsp;&nbsp;Previously filed as Exhibit 4.1 to the Registrant&#8217;s Registration Statement on Form S-1/A filed with the SEC on February 5, 2013 (File No. 333-184779) and incorporated herein by reference.</font></a></p></td>
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<p style="text-align:center;margin-bottom:12pt;margin-top:0pt;margin-left:0pt;;text-indent:0pt;;font-family:Times New Roman;font-size:10pt;font-weight:normal;font-style:normal;text-transform:none;font-variant: normal;">5.1</p></td>
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<p style="margin-bottom:12pt;margin-top:0pt;margin-left:0pt;;text-indent:0pt;;font-family:Times New Roman;font-size:10pt;font-weight:normal;font-style:normal;text-transform:none;font-variant: normal;"><a href="enta-ex51_7.htm"><font style="text-decoration:underline;">Opinion of Foley Hoag LLP.&nbsp;&nbsp;Filed herewith.</font></a></p></td>
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<p style="text-align:center;margin-bottom:12pt;margin-top:0pt;margin-left:0pt;;text-indent:0pt;;font-family:Times New Roman;font-size:10pt;font-weight:normal;font-style:normal;text-transform:none;font-variant: normal;">23.1</p></td>
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<p style="margin-bottom:12pt;margin-top:0pt;margin-left:0pt;;text-indent:0pt;;font-family:Times New Roman;font-size:10pt;font-weight:normal;font-style:normal;text-transform:none;font-variant: normal;"><a href="enta-ex231_6.htm"><font style="text-decoration:underline;">Consent of PricewaterhouseCoopers LLP.&nbsp;&nbsp;Filed herewith.</font></a></p></td>
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<p style="text-align:center;margin-bottom:12pt;margin-top:0pt;margin-left:0pt;;text-indent:0pt;;font-family:Times New Roman;font-size:10pt;font-weight:normal;font-style:normal;text-transform:none;font-variant: normal;">23.2</p></td>
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<p style="margin-bottom:12pt;margin-top:0pt;margin-left:0pt;;text-indent:0pt;;font-family:Times New Roman;font-size:10pt;font-weight:normal;font-style:normal;text-transform:none;font-variant: normal;"><a href="enta-ex51_7.htm"><font style="text-decoration:underline;">Consent of Foley Hoag LLP.&nbsp;&nbsp;Included in the opinion filed as Exhibit 5.1.</font></a></p></td>
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<p style="text-align:center;margin-bottom:12pt;margin-top:0pt;margin-left:0pt;;text-indent:0pt;;font-family:Times New Roman;font-size:10pt;font-weight:normal;font-style:normal;text-transform:none;font-variant: normal;">24.1</p></td>
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<p style="margin-bottom:12pt;margin-top:0pt;margin-left:0pt;;text-indent:0pt;;font-family:Times New Roman;font-size:10pt;font-weight:normal;font-style:normal;text-transform:none;font-variant: normal;"><a href="#POA"><font style="text-decoration:underline;">Power of Attorney.&nbsp;&nbsp;Included on the signature page hereto.</font></a></p></td>
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<p style="text-align:center;margin-bottom:12pt;margin-top:0pt;margin-left:0pt;;text-indent:0pt;;font-family:Times New Roman;font-size:10pt;font-weight:normal;font-style:normal;text-transform:none;font-variant: normal;">99.1</p></td>
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<p style="margin-bottom:12pt;margin-top:0pt;margin-left:0pt;;text-indent:0pt;;font-family:Times New Roman;font-size:10pt;font-weight:normal;font-style:normal;text-transform:none;font-variant: normal;"><a href="http://www.sec.gov/Archives/edgar/data/1177648/000119312517004530/d325877dex1014.htm"><font style="text-decoration:underline;">2012 Equity Incentive Plan (As adjusted to reflect the application of the 1-for-4.31 reverse stock split of the Company&#8217;s common stock effected on March 1, 2013).&nbsp;&nbsp;Previously filed as Exhibit 10.14 to the Registrant&#8217;s Annual Report on Form 10-K/A (Amendment No. 1) filed with the SEC on January 6, 2017 (File No. 001-35839) and incorporated herein by reference.</font></a></p></td>
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<p style="margin-top:12pt;line-height:10pt;margin-bottom:0pt;text-indent:0%;font-family:Times New Roman;font-size:10pt;">&nbsp;</p>
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<p style="margin-bottom:0pt;margin-top:0pt;text-indent:0%;font-family:Times New Roman;font-size:10pt;">&nbsp;</p>
<p style="text-align:center;margin-bottom:12pt;margin-top:0pt;text-indent:0%;font-weight:bold;font-family:Times New Roman;font-size:10pt;font-style:normal;text-transform:none;font-variant: normal;"><a name="_AEIOULastRenderedPageBreakAEIOU5"></a><font style="font-weight:bold;font-family:Times New Roman;font-size:10pt;font-style:normal;text-transform:none;font-variant: normal;">SIGNATURES</font></p>
<p style="margin-bottom:12pt;margin-top:0pt;text-indent:7.34%;font-family:Times New Roman;font-size:10pt;font-weight:normal;font-style:normal;text-transform:none;font-variant: normal;">Pursuant to the requirements of the Securities Act of 1933, the Registrant certifies that it has reasonable grounds to believe that it meets all of the requirements for filing on Form S-8 and has duly caused this Registration Statement to be signed on its behalf by the undersigned, thereunto duly authorized, in the city of Watertown, Commonwealth of Massachusetts, as of May 10, 2019.</p>
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<p style="margin-bottom:0pt;margin-top:0pt;margin-left:0pt;;text-indent:0pt;;font-weight:bold;font-family:Times New Roman;font-size:10pt;font-style:normal;text-transform:none;font-variant: normal;">ENANTA PHARMACEUTICALS, INC.</p></td>
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<p style="margin-bottom:0pt;margin-top:0pt;margin-left:0pt;;text-indent:0pt;;font-size:1pt;">&nbsp;</p></td>
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<p style="margin-bottom:0pt;margin-top:0pt;margin-left:0pt;;text-indent:0pt;;font-size:1pt;">&nbsp;</p></td>
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<p style="text-align:center;margin-bottom:0pt;margin-top:0pt;margin-left:0pt;;text-indent:0pt;;font-size:10pt;font-family:Times New Roman;font-weight:normal;font-style:normal;text-transform:none;font-variant: normal;">By:</p></td>
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<p style="text-align:center;margin-bottom:0pt;margin-top:0pt;margin-left:0pt;;text-indent:0pt;;font-family:Times New Roman;font-size:10pt;font-weight:normal;font-style:normal;text-transform:none;font-variant: normal;">/s/&#160;&#160;&#160;&#160;Jay R. Luly, Ph.D.&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;</p></td>
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<p style="line-height:2pt;margin-bottom:0pt;margin-top:0pt;margin-left:0pt;;text-indent:0pt;;font-size:10pt;font-family:Times New Roman;font-weight:normal;font-style:normal;text-transform:none;font-variant: normal;">&#160;</p></td>
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<p style="text-align:center;margin-bottom:0pt;margin-top:0pt;margin-left:0pt;;text-indent:0pt;;font-family:Times New Roman;font-size:10pt;font-weight:normal;font-style:normal;text-transform:none;font-variant: normal;">Jay R. Luly, Ph.D.</p></td>
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<p style="line-height:2pt;margin-bottom:0pt;margin-top:0pt;margin-left:0pt;;text-indent:0pt;;font-size:10pt;font-family:Times New Roman;font-weight:normal;font-style:normal;text-transform:none;font-variant: normal;">&#160;</p></td>
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<p style="text-align:center;margin-bottom:0pt;margin-top:0pt;margin-left:0pt;;text-indent:0pt;;font-family:Times New Roman;font-size:10pt;font-weight:normal;font-style:normal;text-transform:none;font-variant: normal;">President and Chief Executive Officer</p></td>
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<p style="margin-bottom:0pt;margin-top:0pt;margin-left:47.71%;text-indent:0%;font-family:Times New Roman;font-size:10pt;">&nbsp;</p>
<p style="text-align:center;margin-bottom:12pt;margin-top:0pt;text-indent:0%;font-weight:bold;font-family:Times New Roman;font-size:10pt;font-style:normal;text-transform:none;font-variant: normal;"><a name="POA"></a>POWER OF ATTORNEY</p>
<p style="margin-bottom:12pt;margin-top:0pt;text-indent:7.34%;font-family:Times New Roman;font-size:10pt;font-weight:normal;font-style:normal;text-transform:none;font-variant: normal;">We, the undersigned officers and directors of Enanta Pharmaceuticals, Inc., hereby severally constitute and appoint each of Jay R. Luly and Paul J. Mellett, our true and lawful attorneys&#8209;in&#8209;fact, with full power to them in any and all capacities, to sign any and all amendments to this Registration Statement on Form S&#8209;8 (including any post&#8209;effective amendments thereto), and to file the same, with exhibits thereto and other documents in connection therewith, with the Securities and Exchange Commission, hereby ratifying and confirming all that each of said attorneys&#8209;in&#8209;fact may do or cause to be done by virtue hereof.</p>
<p style="margin-bottom:12pt;margin-top:0pt;text-indent:7.34%;font-family:Times New Roman;font-size:10pt;font-weight:normal;font-style:normal;text-transform:none;font-variant: normal;">Pursuant to the requirements of the Securities Act of 1933, this Registration Statement has been signed below by the following persons in the capacities and as of the dates indicated.</p>
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<p style="text-align:center;margin-bottom:0pt;margin-top:0pt;margin-left:0pt;;text-indent:0pt;;font-size:10pt;font-family:Times New Roman;font-weight:normal;font-style:normal;text-transform:none;font-variant: normal;">/s/&#160;&#160;&#160;&#160;Jay R. Luly, Ph.D.&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;</p>
<p style="text-align:center;border-top:Solid 1pt;padding-top:1pt;margin-top:1pt;line-height:1pt;margin-bottom:0pt;margin-left:0pt;;text-indent:0pt;;font-size:10pt;font-family:Times New Roman;font-weight:normal;font-style:normal;text-transform:none;font-variant: normal;">&#160;</p>
<p style="text-align:center;margin-bottom:1pt;margin-top:0pt;margin-left:0pt;;text-indent:0pt;;font-size:10pt;font-family:Times New Roman;font-weight:normal;font-style:normal;text-transform:none;font-variant: normal;">Jay R. Luly, Ph.D.</p></td>
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<p style="text-align:center;margin-bottom:1pt;margin-top:0pt;margin-left:0pt;;text-indent:0pt;;color:#000000;font-size:10pt;font-family:Times New Roman;font-weight:normal;font-style:normal;text-transform:none;font-variant: normal;">President and Chief Executive <br />Officer and Director<br />(Principal Executive Officer)</p></td>
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<p style="margin-bottom:1pt;margin-top:0pt;margin-left:0pt;;text-indent:0pt;;font-size:10pt;font-family:Times New Roman;font-weight:normal;font-style:normal;text-transform:none;font-variant: normal;">May 10, 2019</p></td>
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<p style="text-align:center;margin-bottom:0pt;margin-top:0pt;margin-left:0pt;;text-indent:0pt;;font-size:10pt;font-family:Times New Roman;font-weight:normal;font-style:normal;text-transform:none;font-variant: normal;">/s/&#160;&#160;&#160;&#160;Paul J. Mellett&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;</p>
<p style="text-align:center;border-top:Solid 1pt;padding-top:1pt;margin-top:1pt;line-height:1pt;margin-bottom:0pt;margin-left:0pt;;text-indent:0pt;;font-size:10pt;font-family:Times New Roman;font-weight:normal;font-style:normal;text-transform:none;font-variant: normal;">&#160;</p>
<p style="text-align:center;margin-bottom:1pt;margin-top:0pt;margin-left:0pt;;text-indent:0pt;;font-size:10pt;font-family:Times New Roman;font-weight:normal;font-style:normal;text-transform:none;font-variant: normal;">Paul J. Mellett</p></td>
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<p style="text-align:center;margin-bottom:0pt;margin-top:0pt;margin-left:0pt;;text-indent:0pt;;font-size:10pt;font-family:Times New Roman;font-weight:normal;font-style:normal;text-transform:none;font-variant: normal;">Chief Financial Officer</p>
<p style="text-align:center;margin-bottom:0pt;margin-top:0pt;margin-left:0pt;;text-indent:0pt;;font-size:10pt;font-family:Times New Roman;font-weight:normal;font-style:normal;text-transform:none;font-variant: normal;">(Principal Financial and</p>
<p style="text-align:center;margin-bottom:1pt;margin-top:0pt;margin-left:0pt;;text-indent:0pt;;font-size:10pt;font-family:Times New Roman;font-weight:normal;font-style:normal;text-transform:none;font-variant: normal;">Accounting Officer)</p></td>
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<p style="margin-bottom:1pt;margin-top:0pt;margin-left:0pt;;text-indent:0pt;;font-size:10pt;font-family:Times New Roman;font-weight:normal;font-style:normal;text-transform:none;font-variant: normal;">May 10, 2019</p></td>
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<p style="text-align:center;margin-bottom:1pt;margin-top:0pt;margin-left:0pt;;text-indent:0pt;;font-size:10pt;font-family:Times New Roman;font-weight:normal;font-style:normal;text-transform:none;font-variant: normal;">Stephen Buckley, Jr.</p></td>
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<p style="text-align:center;margin-bottom:0pt;margin-top:0pt;margin-left:0pt;;text-indent:0pt;;font-family:Times New Roman;font-size:10pt;font-weight:normal;font-style:normal;text-transform:none;font-variant: normal;">Director</p></td>
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<p style="text-align:center;margin-bottom:0pt;margin-top:0pt;margin-left:0pt;;text-indent:0pt;;font-size:10pt;font-family:Times New Roman;font-weight:normal;font-style:normal;text-transform:none;font-variant: normal;">/s/&#160;&#160;&#160;&#160;Bruce L.A. Carter, Ph.D.&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;</p>
<p style="text-align:center;border-top:Solid 1pt;padding-top:1pt;margin-top:1pt;line-height:1pt;margin-bottom:0pt;margin-left:0pt;;text-indent:0pt;;font-size:10pt;font-family:Times New Roman;font-weight:normal;font-style:normal;text-transform:none;font-variant: normal;">&#160;</p>
<p style="text-align:center;margin-bottom:1pt;margin-top:0pt;margin-left:0pt;;text-indent:0pt;;font-size:10pt;font-family:Times New Roman;font-weight:normal;font-style:normal;text-transform:none;font-variant: normal;">Bruce L.A. Carter, Ph.D.</p></td>
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<p style="text-align:center;margin-bottom:0pt;margin-top:0pt;margin-left:0pt;;text-indent:0pt;;font-family:Times New Roman;font-size:10pt;font-weight:normal;font-style:normal;text-transform:none;font-variant: normal;">Director</p></td>
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<p style="margin-bottom:1pt;margin-top:0pt;margin-left:0pt;;text-indent:0pt;;font-size:10pt;font-family:Times New Roman;font-weight:normal;font-style:normal;text-transform:none;font-variant: normal;">May 10, 2019</p></td>
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<p style="margin-bottom:0pt;margin-top:0pt;margin-left:0pt;;text-indent:0pt;;font-family:Times New Roman;font-size:10pt;">&nbsp;</p></td>
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<p style="text-align:center;margin-bottom:0pt;margin-top:0pt;margin-left:0pt;;text-indent:0pt;;font-size:10pt;font-family:Times New Roman;font-weight:normal;font-style:normal;text-transform:none;font-variant: normal;">/s/&#160;&#160;&#160;&#160;George Golumbeski, Ph.D.&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;</p>
<p style="text-align:center;border-top:Solid 1pt;padding-top:1pt;margin-top:1pt;line-height:1pt;margin-bottom:0pt;margin-left:0pt;;text-indent:0pt;;font-size:10pt;font-family:Times New Roman;font-weight:normal;font-style:normal;text-transform:none;font-variant: normal;">&#160;</p>
<p style="text-align:center;margin-bottom:1pt;margin-top:0pt;margin-left:0pt;;text-indent:0pt;;font-size:10pt;font-family:Times New Roman;font-weight:normal;font-style:normal;text-transform:none;font-variant: normal;">George Golumbeski, Ph.D.</p></td>
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<p style="text-align:center;margin-bottom:0pt;margin-top:0pt;margin-left:0pt;;text-indent:0pt;;font-family:Times New Roman;font-size:10pt;font-weight:normal;font-style:normal;text-transform:none;font-variant: normal;">Director</p></td>
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<p style="text-align:center;margin-bottom:0pt;margin-top:0pt;margin-left:0pt;;text-indent:0pt;;font-size:10pt;font-family:Times New Roman;font-weight:normal;font-style:normal;text-transform:none;font-variant: normal;">/s/&#160;&#160;&#160;&#160;Kristine Peterson&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;</p>
<p style="text-align:center;border-top:Solid 1pt;padding-top:1pt;margin-top:1pt;line-height:1pt;margin-bottom:0pt;margin-left:0pt;;text-indent:0pt;;font-size:10pt;font-family:Times New Roman;font-weight:normal;font-style:normal;text-transform:none;font-variant: normal;">&#160;</p>
<p style="text-align:center;margin-bottom:1pt;margin-top:0pt;margin-left:0pt;;text-indent:0pt;;font-size:10pt;font-family:Times New Roman;font-weight:normal;font-style:normal;text-transform:none;font-variant: normal;">Kristine Peterson&#160;</p></td>
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<p style="text-align:center;margin-bottom:0pt;margin-top:0pt;margin-left:0pt;;text-indent:0pt;;font-family:Times New Roman;font-size:10pt;font-weight:normal;font-style:normal;text-transform:none;font-variant: normal;">Director</p></td>
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<p style="text-align:center;margin-bottom:0pt;margin-top:0pt;margin-left:0pt;;text-indent:0pt;;font-size:10pt;font-family:Times New Roman;font-weight:normal;font-style:normal;text-transform:none;font-variant: normal;">/s<font style="color:#000000;font-size:12pt;"> </font><font style="color:#000000;">Lesley Russell, MBChB, MRCP</font></p>
<p style="text-align:center;border-top:Solid 1pt;padding-top:1pt;margin-top:1pt;line-height:1pt;margin-bottom:0pt;margin-left:0pt;;text-indent:0pt;;font-size:10pt;font-family:Times New Roman;font-weight:normal;font-style:normal;text-transform:none;font-variant: normal;">&#160;</p>
<p style="text-align:center;margin-bottom:1pt;margin-top:0pt;margin-left:0pt;;text-indent:0pt;;color:#000000;font-size:10pt;font-family:Times New Roman;font-weight:normal;font-style:normal;text-transform:none;font-variant: normal;">Lesley Russell, MBChB, MRCP</p></td>
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<p style="text-align:center;margin-bottom:0pt;margin-top:0pt;margin-left:0pt;;text-indent:0pt;;font-family:Times New Roman;font-size:10pt;font-weight:normal;font-style:normal;text-transform:none;font-variant: normal;">Director</p></td>
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<p style="margin-bottom:1pt;margin-top:0pt;margin-left:0pt;;text-indent:0pt;;font-size:10pt;font-family:Times New Roman;font-weight:normal;font-style:normal;text-transform:none;font-variant: normal;">May 10, 2019</p></td>
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<p style="margin-bottom:0pt;margin-top:0pt;margin-left:0pt;;text-indent:0pt;;font-family:Times New Roman;font-size:10pt;">&nbsp;</p></td>
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<p style="text-align:center;margin-bottom:0pt;margin-top:0pt;margin-left:0pt;;text-indent:0pt;;font-size:10pt;font-family:Times New Roman;font-weight:normal;font-style:normal;text-transform:none;font-variant: normal;">/s/&#160;&#160;&#160;&#160;Terry Vance&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;</p>
<p style="text-align:center;border-top:Solid 1pt;padding-top:1pt;margin-top:1pt;line-height:1pt;margin-bottom:0pt;margin-left:0pt;;text-indent:0pt;;font-size:10pt;font-family:Times New Roman;font-weight:normal;font-style:normal;text-transform:none;font-variant: normal;">&#160;</p>
<p style="text-align:center;margin-bottom:1pt;margin-top:0pt;margin-left:0pt;;text-indent:0pt;;font-size:10pt;font-family:Times New Roman;font-weight:normal;font-style:normal;text-transform:none;font-variant: normal;">Terry Vance</p></td>
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<p style="text-align:center;margin-bottom:0pt;margin-top:0pt;margin-left:0pt;;text-indent:0pt;;font-family:Times New Roman;font-size:10pt;font-weight:normal;font-style:normal;text-transform:none;font-variant: normal;">Director</p></td>
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enta-s8.htm
AS FILED WITH THE SECURITIES AND EXCHANGE COMMISSION ON MAY 10, 2019
REGISTRATION NO. 333-
UNITED STATES
SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
____________________
FORM S-8
REGISTRATION STATEMENT
UNDER
THE SECURITIES ACT OF 1933
____________________
ENANTA PHARMACEUTICALS, INC.
(Exact name of registrant as specified in its charter)
____________________
Delaware
04-3205099
(State or other jurisdiction of incorporation or organization)
(I.R.S. Employer Identification No.)
500 Arsenal Street, Watertown, MA
(Address of Principal Executive Offices)
02472
(Zip Code)
2012 Equity Incentive Plan
(Full title of the plan)
____________________
Jay R. Luly
President and Chief Executive Officer
Enanta Pharmaceuticals, Inc.
500 Arsenal Street
Watertown, Massachusetts 02472
(Name and address of agent for service)
(617) 607-0800
(Telephone number, including area code, of agent for service)
____________________
Copy to:
Stacie S. Aarestad, Esq.
Foley Hoag LLP
155 Seaport Boulevard
Boston, Massachusetts 02110-2600
(617) 832-1000
____________________
Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, a non‑accelerated filer, a smaller reporting company or an emerging growth company. See the definitions of "large accelerated filer," "accelerated filer," "smaller reporting company" and "emerging growth company" in Rule 12b‑2 of the Exchange Act.
Large accelerated filer
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Accelerated filer
☐
Non-accelerated filer
☐
Smaller reporting company
☐
Emerging growth company
☐
If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards
provided pursuant to Section 7(a)(2)(B) of the Securities Act.
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CALCULATION OF REGISTRATION FEE
Title of each class of securities to be registered
Amount to be registered(1)
Proposed maximum offering price
per share(2)
Proposed maximum aggregate offering
price(3)
Amount of registration fee
Common Stock, $0.01 par value
241,826 shares
$78.39
$18,956,740.14
$2,297.56
(1)
This Registration Statement covers an aggregate of 241,826 shares of the Registrant's Common Stock, par value $0.01 per share (the "Common Stock"), that are issuable with respect to outstanding options previously granted under the Registrant's 2012 Equity Incentive Plan (the "2012 Plan"). In addition, pursuant to Rule 416(a) under the Securities Act of 1933, as amended (the "Securities Act") this Registration Statement also covers such additional shares of Common Stock as may be issued to prevent dilution from stock splits, stock dividends and similar transactions.
(2)
Estimated solely for the purpose of calculating the registration fee pursuant to paragraphs (c) and (h) of Rule 457 under the Securities Act. For the shares of common stock reserved for issuance upon the exercise of outstanding options previously granted pursuant to the 2012 Plan, the proposed maximum offering price is $78.39 per share, which is the weighted average exercise price (rounded to the nearest cent) of the outstanding awards under the 2012 Plan and the grant date fair value per share of common stock underlying outstanding performance share unit awards made under the 2012 Plan.
(3)
Reflects the aggregate offering price based on the weighted average exercise price of the outstanding options and the grant date fair value of shares underlying outstanding performance share unit awards described in Note 2 above.
Statement Regarding Incorporation by Reference from Effective Registration Statement
Pursuant to Instruction E to Form S-8, the Registrant incorporates by reference into this Registration Statement the entire contents of its Registration Statements on Form S-8 filed with the Securities and Exchange Commission on
June 10, 2013
(File No. 333-189217) ,
December 18, 2013
(File No. 333-192935),
February 24, 2015
(File No. 333- 202257),
February 16, 2016
(File No. 333-209542),
December 9, 2016
(File No. 333-215011) and
December 11, 2017
(File No. 333-221988).
The number of shares of Common Stock, $0.01 par value per share, of the Company available for issuance under the 2012 Plan was subject to an automatic annual increase on the first day of each fiscal year of the Company equal to the least of (i) 3% of the outstanding shares on such date, (ii) 2,088,167 shares of Common Stock, or (iii) an amount determined by the Board. This Registration Statement registers the 241,826 shares of Common Stock that are subject to outstanding option and performance share unit awards that were made following the automatic annual increase of 582,637 shares of Common Stock on October 1, 2018 and prior to the approval of the Registrant's 2019 Equity Incentive Plan (the "2019 Plan") at the Registrant's annual stockholder meeting on February 28, 2019.  The 340,811 shares of Common Stock that remained available for future issuance under the 2012 Plan immediately prior to stockholder approval of the 2019 Plan on February 28, 2019 became available for issuance under the 2019 Plan in accordance with its terms at such time. Those shares are being registered on a Registration Statement on Form S-8 being filed by the Registrant to register shares issuable under the 2019 Plan contemporaneously with the filing of this Registration Statement on Form S-8.
Part II
INFORMATION REQUIRED IN THE REGISTRATION STATEMENT
Item 8.  Exhibits.
Exhibit
Number
Description
4.1
Restated Certificate of Incorporation of Enanta Pharmaceuticals, Inc.  Previously filed as Exhibit 3.1 to the Registrant's Current Report on Form 8‑K filed with the SEC on March 28, 2013 (File No. 001-35839) and incorporated herein by reference
.
4.2
Amended and Restated Bylaws of Enanta Pharmaceuticals, Inc. (as amended and restated in August 2015).  Previously filed as Exhibit 3.2 to the Registrant's Current Report on Form 8‑K filed with the SEC on August 18, 2015 (File No. 001-35839) and incorporated herein by reference.
4.3
Specimen certificate evidencing shares of common stock of Enanta Pharmaceuticals, Inc.  Previously filed as Exhibit 4.1 to the Registrant's Registration Statement on Form S-1/A filed with the SEC on February 5, 2013 (File No. 333-184779) and incorporated herein by reference.
5.1
Opinion of Foley Hoag LLP.  Filed herewith.
23.1
Consent of PricewaterhouseCoopers LLP.  Filed herewith.
23.2
Consent of Foley Hoag LLP.  Included in the opinion filed as Exhibit 5.1.
24.1
Power of Attorney.  Included on the signature page hereto.
99.1
2012 Equity Incentive Plan (As adjusted to reflect the application of the 1-for-4.31 reverse stock split of the Company's common stock effected on March 1, 2013).  Previously filed as Exhibit 10.14 to the Registrant's Annual Report on Form 10-K/A (Amendment No. 1) filed with the SEC on January 6, 2017 (File No. 001-35839) and incorporated herein by reference.
SIGNATURES
Pursuant to the requirements of the Securities Act of 1933, the Registrant certifies that it has reasonable grounds to believe that it meets all of the requirements for filing on Form S-8 and has duly caused this Registration Statement to be signed on its behalf by the undersigned, thereunto duly authorized, in the city of Watertown, Commonwealth of Massachusetts, as of May 10, 2019.
ENANTA PHARMACEUTICALS, INC.
By:
/s/    Jay R. Luly, Ph.D.
Jay R. Luly, Ph.D.
President and Chief Executive Officer
POWER OF ATTORNEY
We, the undersigned officers and directors of Enanta Pharmaceuticals, Inc., hereby severally constitute and appoint each of Jay R. Luly and Paul J. Mellett, our true and lawful attorneys‑in‑fact, with full power to them in any and all capacities, to sign any and all amendments to this Registration Statement on Form S‑8 (including any post‑effective amendments thereto), and to file the same, with exhibits thereto and other documents in connection therewith, with the Securities and Exchange Commission, hereby ratifying and confirming all that each of said attorneys‑in‑fact may do or cause to be done by virtue hereof.
Pursuant to the requirements of the Securities Act of 1933, this Registration Statement has been signed below by the following persons in the capacities and as of the dates indicated.
Signature
Title
Date
/s/    Jay R. Luly, Ph.D.
Jay R. Luly, Ph.D.
President and Chief Executive
Officer and Director
(Principal Executive Officer)
May 10, 2019
/s/    Paul J. Mellett
Paul J. Mellett
Chief Financial Officer
(Principal Financial and
Accounting Officer)
May 10, 2019
Stephen Buckley, Jr.
Director
/s/    Bruce L.A. Carter, Ph.D.
Bruce L.A. Carter, Ph.D.
Director
May 10, 2019
/s/    George Golumbeski, Ph.D.
George Golumbeski, Ph.D.
Director
May 10, 2019
/s/    Kristine Peterson
Kristine Peterson
Director
May 10, 2019
/s
Lesley Russell, MBChB, MRCP
Lesley Russell, MBChB, MRCP
Director
May 10, 2019
/s/    Terry Vance
Terry Vance
Director
May 10, 2019