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<font style="font-family: Times New Roman; font-size: 13px">As
filed with the Securities and Exchange Commission on March 25,
2021</font></div>
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<font style="font-family: Times New Roman; font-size: 13px">&#xA0;&#xA0;&#xA0;&#xA0;&#xA0;Registration
No. 333-</font></div>
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<font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
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<font style="font-weight: bold; font-family: Times New Roman; font-size: 13px">
UNITED STATES</font></div>
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<font style="font-weight: bold; font-family: Times New Roman; font-size: 13px">
SECURITIES AND EXCHANGE COMMISSION</font></div>
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<font style="font-weight: bold; font-family: Times New Roman; font-size: 13px">
Washington, D.C. 20549</font></div>
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&#xA0;&#xA0;&#xA0;&#xA0;&#xA0;&#xA0;&#xA0;&#xA0;&#xA0;&#xA0;</font></div>
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<font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
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<font style="font-weight: bold; font-family: Times New Roman; font-size: 13px">
FORM S-8</font></div>
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<font style="font-weight: bold; font-family: Times New Roman; font-size: 13px">
REGISTRATION STATEMENT UNDER THE SECURITIES ACT OF
1933</font></div>
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<font style="font-weight: bold; font-family: Times New Roman; font-size: 16px">
ENDRA LIFE SCIENCES INC.</font></div>
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<font style="font-family: Times New Roman; font-size: 13px">(Exact
name of registrant as specified in its charter)</font></div>
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<font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
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<font style="font-weight: bold; font-family: Times New Roman; font-size: 13px">
Delaware</font></div>
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<font style="font-weight: bold; font-family: Times New Roman; font-size: 13px">
26-0579295</font></div>
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<font style="font-family: Times New Roman; font-size: 13px">(State
or other jurisdiction of incorporation or
organization)</font></div>
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<font style="font-family: Times New Roman; font-size: 13px">(I.R.S.
Employer Identification No.)</font></div>
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<font style="font-weight: bold; font-family: Times New Roman; font-size: 13px">
3600 Green Court, Suite 350</font></div>
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<font style="font-weight: bold; font-family: Times New Roman; font-size: 13px">
Ann Arbor, MI</font></div>
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<font style="font-weight: bold; font-family: Times New Roman; font-size: 13px">
48105</font></div>
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<font style="font-family: Times New Roman; font-size: 13px">(Address
of principal executive offices)</font></div>
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<font style="font-family: Times New Roman; font-size: 13px">(Zip
Code)</font></div>
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<font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
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<font style="font-weight: bold; font-family: Times New Roman; font-size: 13px">
ENDRA Life Sciences Inc. 2016 Omnibus Incentive Plan</font></div>
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<font style="font-family: Times New Roman; font-size: 13px">&#xA0;(Full
title of the plan)</font></div>
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<font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
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<font style="font-weight: bold; font-family: Times New Roman; font-size: 13px">
Francois Michelon</font></div>
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<font style="font-weight: bold; font-family: Times New Roman; font-size: 13px">
Chief Executive Officer</font></div>
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<font style="font-weight: bold; font-family: Times New Roman; font-size: 13px">
ENDRA Life Sciences Inc.</font></div>
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<font style="font-weight: bold; font-family: Times New Roman; font-size: 13px">
3600 Green Court, Suite 350</font></div>
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<font style="font-weight: bold; font-family: Times New Roman; font-size: 13px">
Ann Arbor, MI 48105</font></div>
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<font style="font-family: Times New Roman; font-size: 13px">(Name
and address of agent for service)</font></div>
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<font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
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<font style="font-weight: bold; font-family: Times New Roman; font-size: 13px">
(734) 335-0468</font></div>
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<font style="font-family: Times New Roman; font-size: 13px">(Telephone
number, including area code,</font></div>
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<font style="font-family: Times New Roman; font-size: 13px">of
agent for service)</font></div>
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<font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
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<font style="font-family: Times New Roman; font-size: 13px">Indicate by check
mark whether the registrant is a large accelerated filer, an
accelerated filer, a non-accelerated filer, a smaller reporting
company or an emerging growth company. See the definitions of
&#x201C;large accelerated filer,&#x201D; &#x201C;accelerated
filer,&#x201D; &#x201C;smaller reporting company&#x201D; and
&#x201C;emerging growth company&#x201D; in Rule 12b-2 of the Exchange
Act.</font></div>
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<font style="font-family: Times New Roman; font-size: 13px;">&#xA0;</font></div>
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<font style="font-family: Times New Roman; font-size: 13px">Large
accelerated filer</font></div>
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<td style="vertical-align: top; width: 5%;">
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<font style="font-family: Times New Roman; font-size: 13px">&#x2610;</font></div>
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<td style="width: 30%;">
<div><font>&#xA0;</font></div>
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<font style="font-family: Times New Roman; font-size: 13px">Accelerated
filer</font></div>
</td>
<td style="vertical-align: top; width: 5%;">
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">&#x2610;</font></div>
</td>
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<font style="font-family: Times New Roman; font-size: 13px">Non-accelerated
filer</font></div>
</td>
<td style="vertical-align: top; width: 5%;">
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<font style="font-size: 13px">&#x2611;</font></div>
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<td style="width: 30%;">
<div><font>&#xA0;</font></div>
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<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">Smaller
reporting company</font></div>
</td>
<td style="vertical-align: top; width: 5%;">
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-size: 13px">&#x2611;</font></div>
</td>
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<td style="vertical-align: top; width: 30%;">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 5%;">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="width: 30%;">
<div><font>&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 30%;">
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">Emerging
growth company</font></div>
</td>
<td style="vertical-align: top; width: 5%;">
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-size: 13px">&#x2611;</font></div>
</td>
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</div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</div>
<div style="text-align: left"><font style="font-family: Times New Roman; font-size: 13px">If an emerging
growth company, indicate by check mark if the registrant has
elected not to use the extended transition period for complying
with any new or revised financial accounting standards pursuant to
Section 7(a)(2)(B) of the Securities Act. &#x25A1;</font></div>
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<font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
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<div style="text-align: center"><font style="font-family: Times New Roman; font-size: 13px;">&#xA0;</font></div>
<div style="text-align: center"><font style="font-family: Times New Roman; font-size: 13px">CALCULATION OF
REGISTRATION FEE</font></div>
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<font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
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<div style="text-align: center; text-indent:0px;margin-right:0px;margin-left:0px;"><font style="font-size: 11px"><font style="font-family: Times New Roman; font-weight: bold;">Title</font></font></div>
<div style="text-align: center; text-indent:0px;margin-right:0px;margin-left:0px;"><font style="font-size: 11px"><font style="font-weight: bold"><font style="font-weight: bold"><font style="font-family: Times New Roman; font-weight: bold;">of Securities to
be</font></font></font></font></div>
<div style="text-align: center; text-indent:0px;margin-right:0px;margin-left:0px;"><font style="font-size: 11px"><font style="font-weight: bold"><font style="font-weight: bold"><font style="font-family: Times New Roman; font-weight: bold;">Registered</font></font></font></font></div>
</td>
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<div><font style="font-weight: bold; font-size: 11px;"><font style="text-align: left; vertical-align: bottom; width: 10%; display: inline-block; font-weight: bold;">&#xA0;</font><font style="text-align: center; vertical-align: bottom; width: 80%; display: inline-block; font-weight: bold;">
<div><font style="font-family: Times New Roman; font-weight: bold;">Amount</font></div>
<div><font style="font-family: Times New Roman; font-weight: bold;">to
be</font></div>
<div><font style="font-family: Times New Roman; font-weight: bold;">Registered
(1)</font></div>
</font><font style="text-align: left; vertical-align: bottom; width: 10%; display: inline-block; font-weight: bold;">&#xA0;</font></font></div>
</td>
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<div><font style="font-weight: bold; font-size: 11px;"><font style="text-align: left; vertical-align: bottom; width: 10%; display: inline-block; font-weight: bold;">&#xA0;</font><font style="text-align: center; vertical-align: bottom; width: 80%; display: inline-block; font-weight: bold;">
<div><font style="font-family: Times New Roman; font-weight: bold;">Proposed
Maximum</font></div>
<div><font style="font-family: Times New Roman; font-weight: bold;">Offering
Price</font></div>
<div><font style="font-family: Times New Roman; font-weight: bold;">Per Share
(2)</font></div>
</font><font style="text-align: left; vertical-align: bottom; width: 10%; display: inline-block; font-weight: bold;">&#xA0;</font></font></div>
</td>
<td rowspan="1" style="vertical-align: bottom; width: 12%; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);">
<div><font style="font-weight: bold; font-size: 11px;"><font style="text-align: left; vertical-align: bottom; width: 10%; display: inline-block; font-weight: bold;">&#xA0;</font><font style="text-align: center; vertical-align: bottom; width: 80%; display: inline-block; font-weight: bold;">
<div><font style="font-family: Times New Roman; font-weight: bold;">Proposed
Maximum</font></div>
<div><font style="font-family: Times New Roman; font-weight: bold;">Aggregate</font></div>
<div><font style="font-family: Times New Roman; font-weight: bold;">Offering
Price</font></div>
</font><font style="text-align: left; vertical-align: bottom; width: 10%; display: inline-block; font-weight: bold;">&#xA0;</font></font></div>
</td>
<td rowspan="1" style="vertical-align: bottom; width: 12%; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0);">
<div><font style="font-weight: bold; font-size: 11px;"><font style="text-align: left; vertical-align: bottom; width: 10%; display: inline-block; font-weight: bold;">&#xA0;</font><font style="text-align: center; vertical-align: bottom; width: 80%; display: inline-block; font-weight: bold;">
<div><font style="font-family: Times New Roman; font-weight: bold;">Amount
of</font></div>
<div><font style="font-family: Times New Roman; font-weight: bold;">Registration</font></div>
<div><font style="font-family: Times New Roman; font-weight: bold;">Fee</font></div>
</font><font style="text-align: left; vertical-align: bottom; width: 10%; display: inline-block; font-weight: bold;">&#xA0;</font></font></div>
</td>
</tr><tr style="background-color:#cceeff;">
<td style="vertical-align: bottom; width: 52%; border-top: 2px solid rgb(0, 0, 0); border-bottom: 4px double rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);">
<div style="text-align: left; text-indent: 0px; margin-right: 0px; margin-left: 0px;"><font style="font-family: Times New Roman; font-size: 13px">Common Stock,
$0.0001 par value per share, to be issued under the
Registrant&#x2019;s 2016 Omnibus Incentive Plan</font></div>
</td>
<td style="vertical-align: bottom; width: 12%; border-top: 2px solid rgb(0, 0, 0); border-bottom: 4px double rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);">
<div><font style="text-align: left; font-family: Times New Roman; vertical-align: bottom; display: inline-block; width: 10%; font-size: 13px;">&#xA0;</font><font style="text-align: left; font-family: Times New Roman; vertical-align: bottom; font-size: 13px; display: inline-block; width: 5%;">&#xA0;</font><font style="text-align: right; font-family: Times New Roman; vertical-align: bottom; font-size: 13px; display: inline-block; width: 75%;">1,599,570</font><font style="text-align: left; font-family: Times New Roman; vertical-align: bottom; display: inline-block; width: 10%; font-size: 13px;">(3)</font></div>
</td>
<td style="vertical-align: bottom; width: 12%; border-top: 2px solid rgb(0, 0, 0); border-bottom: 4px double rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);">
<div><font style="text-align: left; font-family: Times New Roman; vertical-align: bottom; display: inline-block; width: 10%; font-size: 13px;">&#xA0;</font><font style="text-align: left; font-family: Times New Roman; vertical-align: bottom; display: inline-block; width: 5%; font-size: 13px;">$</font><font style="text-align: right; font-family: Times New Roman; vertical-align: bottom; display: inline-block; width: 75%; font-size: 13px;">2.73</font><font style="text-align: left; font-family: Times New Roman; vertical-align: bottom; display: inline-block; width: 10%; font-size: 13px;">&#xA0;</font></div>
</td>
<td style="vertical-align: bottom; width: 12%; border-top: 2px solid rgb(0, 0, 0); border-bottom: 4px double rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);">
<div><font style="text-align: left; font-family: Times New Roman; vertical-align: bottom; display: inline-block; width: 10%; font-size: 13px;">&#xA0;</font><font style="text-align: left; font-family: Times New Roman; vertical-align: bottom; display: inline-block; width: 5%; font-size: 13px;">$</font><font style="text-align: right; font-family: Times New Roman; vertical-align: bottom; display: inline-block; width: 75%; font-size: 13px;">4,366,826.10</font><font style="text-align: left; font-family: Times New Roman; vertical-align: bottom; display: inline-block; width: 10%; font-size: 13px;">&#xA0;</font></div>
</td>
<td style="vertical-align: bottom; width: 12%; border-color: rgb(0, 0, 0); border-style: solid solid double; border-width: 2px 2px 4px;">
<div><font style="text-align: left; font-family: Times New Roman; vertical-align: bottom; display: inline-block; width: 10%; font-size: 13px;">&#xA0;</font><font style="text-align: left; font-family: Times New Roman; vertical-align: bottom; font-size: 13px; display: inline-block; width: 5%;">$</font><font style="text-align: right; font-family: Times New Roman; vertical-align: bottom; font-size: 13px; display: inline-block; width: 75%;">476.42</font><font style="text-align: left; font-family: Times New Roman; vertical-align: bottom; display: inline-block; width: 10%; font-size: 13px;">&#xA0;</font></div>
</td>
</tr></table>
</div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</div>
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">(1) In
addition, pursuant to Rule 416(a), this Registration Statement also
covers such indeterminate number of additional shares of Common
Stock as is necessary to eliminate any dilutive effect of any
future stock split, stock dividend or similar
transaction.</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">(2)
Estimated solely for the purpose of calculating the registration
fee pursuant to Rule 457(c) and 457(h) of the Securities Act of
1933, as amended, and based on the average of the high and low
prices for the Registrant&#x2019;s Common Stock on March 22, 2021,
as reported on The Nasdaq Capital Market.</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">(3)
Represents 1,599,570 additional shares of Common Stock that were
automatically&#xA0;added to the shares authorized for issuance
under the Registrant&#x2019;s 2016 Omnibus Incentive Plan, as
amended (the &#x201C;Plan&#x201D;), on January 1, 2021 pursuant to an
annual &#x201C;evergreen&#x201D; increase provision contained in the
Plan. Pursuant to such provision, the number of shares reserved for
issuance under the Plan <a name="T1">
<!--anchor--></a>automatically&#xA0;increases on each January 1 by
the lesser of (a) the number of shares necessary such that the
aggregate number of shares available under the Plan equals 25% of
the number of fully-diluted outstanding shares on the increase date
(assuming the conversion of all outstanding shares of preferred
stock and other outstanding convertible securities and the exercise
of all outstanding options and warrants to purchase shares), and
(b) a number of shares determined by the Registrant&#x2019;s board
of directors.</font></div>
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px;">&#xA0;</font></div>
<div id="pgbrk" style="width: 100%; margin-left: 0px; text-indent: 0px; margin-right: 0px">
<div id="ftr">
<div style="text-align: left; width: 100%; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</div>
<div id="pb" style="text-align: center; page-break-after: always; margin-left: 0px; margin-right: 0px; margin-bottom: 6px; width: 100%; height: 1px; background-color: #000000">
<!--page break--></div>
<div id="hdr">
<div style="text-align: left; width: 100%; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</div>
</div>
<div><font style="font-family: Times New Roman; font-size: 10">&#xA0;</font></div>
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; font-family: Times New Roman; font-size: 13px">
EXPLANATORY NOTE</font></div>
<div><font style="font-family: Times New Roman; font-size: 10">&#xA0;</font></div>
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 48px">
<font style="font-family: Times New Roman; font-size: 13px">This
Registration Statement on Form S-8 is being filed to register an
additional 1,599,570 shares of Common Stock under the ENDRA Life
Sciences Inc. 2016 Omnibus Incentive Plan, as amended (the
&#x201C;Plan&#x201D;), as a result of an evergreen provision in the
Plan providing that the total number of shares of Common Stock
reserved for issuance under the Plan is automatically increased as
of each January 1.</font></div>
<div><font style="font-family: Times New Roman; font-size: 10">&#xA0;</font></div>
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 48px">
<font style="font-family: Times New Roman; font-size: 13px">These
additional shares of Common Stock are securities of the same class
as other securities for which the Registration Statements on Form
S-8 (File Nos. 333-218894, 333-233178 and 333-237415) (the
&#x201C;Prior Registration Statements&#x201D;) were filed with the
Securities and Exchange Commission (the &#x201C;Commission&#x201D;)
on June 21, 2017, August 9, 2019 and March 26, 2020, respectively.
In accordance with Instruction E of Form S-8, the content of the
Prior Registration Statements are incorporated herein by reference
and made a part of this Registration Statement on Form
S-8.</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; font-family: Times New Roman; font-size: 13px">
PART I</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; font-family: Times New Roman; font-size: 13px">
INFORMATION REQUIRED IN THE SECTION 10(a) PROSPECTUS</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
<div style="text-align: left; margin-left: 0px; text-indent: 0px; margin-right: 0px;"><font style="font-weight: bold; font-family: Times New Roman; font-size: 13px">Item
1. Plan Information.</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 48px">
<font style="font-family: Times New Roman; font-size: 13px">The
information required by this Item 1 is omitted from this
registration statement in accordance with Rule 428(b)(1) of the
Securities Act of 1933, as amended (the &#x201C;Securities
Act&#x201D;), and the Note to Part I of Form S-8.</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
<div style="text-align: left; margin-left: 0px; text-indent: 0px; margin-right: 0px;"><font style="font-weight: bold; font-family: Times New Roman; font-size: 13px">Item
2. Registrant Information and Employee Plan Annual
Information.</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 48px">
<font style="font-family: Times New Roman; font-size: 13px">The
information required by this Item 2 is omitted from this
registration statement in accordance with Rule 428(b)(1) of the
Securities Act and the Note to Part I of Form S-8.</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; font-family: Times New Roman; font-size: 13px">
PART II</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; font-family: Times New Roman; font-size: 13px">
INFORMATION REQUIRED IN THE REGISTRATION STATEMENT</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
<div style="text-align: left; margin-left: 0px; text-indent: 0px; margin-right: 0px;"><font style="font-weight: bold; font-family: Times New Roman; font-size: 13px">Item
3. Incorporation of Documents by Reference.</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 48px">
<font style="font-family: Times New Roman; font-size: 13px">The
following documents have been filed by ENDRA Life Sciences Inc.
(the &#x201C;Registrant&#x201D;) with the Commission and are
incorporated herein by reference:</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
<div style="margin-left: 0px; display: table">
<div style="display: table-row">
<div style="text-align: left; display: table-cell; width: 48px">
<font style="font-size: 13px">&#x25CF;</font></div>
<div style="text-align: justify; display: table-cell"><font style="font-family: Times New Roman; font-size: 13px">Annual Report on
Form 10-K for the fiscal year ended December 31, 2020, filed with
the Commission on March 25, 2021;</font></div>
</div>
</div>
<div><font style="font-family: Times New Roman; font-size: 10">&#xA0;</font></div>
<div style="margin-left: 0px; display: table">
<div style="display: table-row">
<div style="text-align: left; display: table-cell; width: 48px">
<font style="font-size: 13px">&#x25CF;</font></div>
<div style="text-align: justify; display: table-cell"><font style="font-family: Times New Roman; font-size: 13px">Current Reports on
Form 8-K, filed with the Commission on February 3, 2021 and
February 19, 2021; and</font></div>
</div>
</div>
<div><font style="font-family: Times New Roman; font-size: 10">&#xA0;</font></div>
<div id="pgbrk" style="width: 100%; margin-left: 0px; text-indent: 0px; margin-right: 0px">
<div id="ftr">
<div style="text-align: left; width: 100%"><font style="font-family: Times New Roman; font-size: 11px">&#xA0;</font></div>
</div>
<div id="pb" style="text-align: center; margin-left: 0px; margin-right: 0px; margin-bottom: 6px; page-break-after: always; width: 100%; height: 1px; background-color: #000000">
<!--page break line--></div>
<div id="hdr">
<div style="text-align: right; width: 100%"><font style="font-family: Times New Roman; font-size: 11px">&#xA0;</font></div>
</div>
</div>
<div><font style="font-family: Times New Roman; font-size: 13px;">&#xA0;</font></div>
<div style="margin-left: 0px; display: table">
<div style="display: table-row">
<div style="text-align: left; display: table-cell; width: 48px">
<font style="font-size: 13px">&#x25CF;</font></div>
<div style="text-align: justify; display: table-cell"><font style="font-family: Times New Roman; font-size: 13px">The description of
the Registrant&#x2019;s Common Stock contained in the
Registrant&#x2019;s Registration Statement on Form S-1, originally
filed with the Commission on November 21, 2016, as amended (File
No. 333-214724), which description is incorporated by reference
into the Registrant&#x2019;s Registration Statement on Form 8-A,
originally filed with the Commission pursuant to Section 12(g) of
the Exchange Act on December 16, 2016 (File No. 001-37969),
including any further amendment or report filed hereafter for the
purpose of updating such description.</font></div>
</div>
</div>
<div><font style="font-family: Times New Roman; font-size: 10">&#xA0;</font></div>
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 48px">
<font style="font-family: Times New Roman; font-size: 13px">All
reports and other documents filed by the Registrant pursuant to
Sections 13(a), 13(c), 14 or 15(d) of the Exchange Act after the
date hereof, and prior to the filing of a post-effective amendment
which indicates that all securities offered hereby have been sold
or which deregisters all securities then remaining unsold, shall be
deemed to be incorporated by reference herein and to be part hereof
from the date of filing of such reports and documents. The
Registrant is not incorporating by reference any reports or
documents or portions thereof that are not considered to be
&#x201C;filed&#x201D; with the Commission.</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 48px">
<font style="font-family: Times New Roman; font-size: 13px">Any
statement contained herein or in a document incorporated or deemed
to be incorporated herein by reference shall be deemed to be
modified or superseded for purposes of this Registration Statement
to the extent that a statement contained herein or in any other
subsequently filed document which also is or is deemed to be
incorporated herein by reference modifies or supersedes such
earlier statement. Any statement so modified or superseded shall
not be deemed, except as so modified or superseded, to constitute a
part of this Registration Statement.</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
<div style="text-align: left; margin-left: 0px; text-indent: 0px; margin-right: 0px;"><font style="font-weight: bold; font-family: Times New Roman; font-size: 13px">Item
8. Exhibits.</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px;">&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">

<div style="display: table">
<div style="display: table-row">
<div style="display: table-cell; width: 96px"><font style="font-family: Times New Roman; font-size: 13px"><font style="color: #000000">Exhibit<br></font></font></div>
<div style="text-align: left; display: table-cell"><font style="text-decoration: underline; color: #000000; font-family: Times New Roman; font-size: 13px">
<br></font></div>
</div>
</div>
<div style="display: table">
<div style="display: table-row">
<div style="display: table-cell; width: 96px"><font style="font-family: Times New Roman; font-size: 13px"><font style="color: #000000"><font style="text-decoration: underline">Number</font><br></font></font></div>
<div style="text-align: left; display: table-cell"><font style="font-family: Times New Roman; font-size: 13px;"><font style="text-decoration: underline; color: #000000; font-family: Times New Roman; font-size: 13px">
Description</font>&#xA0;<br></font></div>
</div>
</div>
<div style="display: table"><br></div>
</div>
<div style="display: table">
<div style="display: table-row">
<div style="display: table-cell; width: 96px"><font style="font-family: Times New Roman; font-size: 13px"><font style="color: rgb(50, 99, 236);"><a href="http://www.sec.gov/Archives/edgar/data/1681682/000165495417004582/ndra_ex32.htm">
4.1</a></font>&#xA0;</font></div>
<div style="text-align: left; display: table-cell"><font style="color: #000000; font-family: Times New Roman; font-size: 13px">Fourth
Amended and Restated Certificate of Incorporation of ENDRA Life
Sciences Inc. (incorporated by reference to Exhibit 3.2 to the
Registrant&#x2019;s Current Report on Form 8-K filed on May 12,
2017)</font></div>
</div>
</div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
<div style="display: table">
<div style="display: table-row">
<div style="display: table-cell; width: 96px"><font style="color: rgb(50, 99, 236);"><a href="http://www.sec.gov/Archives/edgar/data/1681682/000165495420006789/ndra_ex31.htm">
<font style="font-family: Times New Roman; font-size: 13px">4.2</font></a></font></div>
<div style="text-align: left; display: table-cell"><font style="color: #000000; font-family: Times New Roman; font-size: 13px">Certificate
of Amendment to the Fourth Amended and Restated Certificate of
Incorporation of the Company (incorporated by reference to Exhibit
3.1 to the Registrant&#x2019;s Current Report on Form 8-K filed on
June 18, 2020)</font></div>
</div>
</div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
<div style="display: table">
<div style="display: table-row">
<div style="display: table-cell; width: 96px"><font style="color: rgb(50, 99, 236);"><a href="http://www.sec.gov/Archives/edgar/data/1681682/000165495416004599/end_ex34.htm">
<font style="font-family: Times New Roman; font-size: 13px">4.3</font></a></font></div>
<div style="text-align: left; display: table-cell"><font style="color: #000000; font-family: Times New Roman; font-size: 13px">Amended
and Restated Bylaws of ENDRA Life Sciences Inc. (incorporated by
reference to Exhibit 3.4 to Amendment No. 1 to the
Registrant&#x2019;s Registration Statement on Form S-1 (File No.
333-214724) filed on December 6, 2016)</font></div>
</div>
</div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
<div style="display: table">
<div style="display: table-row">
<div style="display: table-cell; width: 96px"><font style="color: rgb(50, 99, 236);"><a href="http://www.sec.gov/Archives/edgar/data/1681682/000165495416004599/end_ex104.htm">
<font style="font-family: Times New Roman; font-size: 13px">4.4</font></a></font></div>
<div style="text-align: left; display: table-cell"><font style="color: #000000; font-family: Times New Roman; font-size: 13px">ENDRA
Life Sciences Inc. 2016 Omnibus Incentive Plan (incorporated by
reference to Exhibit 10.4 to Amendment No. 1 to the
Registrant&#x2019;s Registration Statement on Form S-1 (File No.
333-214724) filed on December 6, 2016)</font></div>
</div>
</div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
<div style="display: table">
<div style="display: table-row">
<div style="display: table-cell; width: 96px"><font style="color: rgb(50, 99, 236);"><a href="http://www.sec.gov/Archives/edgar/data/1681682/000121390018005842/def14a061218_endralife.htm">
<font style="font-family: Times New Roman; font-size: 13px">4.5</font></a></font></div>
<div style="text-align: left; display: table-cell"><font style="color: #000000; font-family: Times New Roman; font-size: 13px">First
Amendment to ENDRA Life Sciences Inc. 2016 Omnibus Incentive Plan
(incorporated by reference to Appendix A to the Registrant&#x2019;s
Definitive Proxy Statement filed on May 10, 2018)</font></div>
</div>
</div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
<div style="display: table">
<div style="display: table-row">
<div style="display: table-cell; width: 96px"><font style="color: rgb(50, 99, 236);"><a href="http://www.sec.gov/Archives/edgar/data/1681682/000165495416004599/end_ex105.htm">
<font style="font-family: Times New Roman; font-size: 13px">4.6</font></a></font></div>
<div style="text-align: left; display: table-cell"><font style="color: #000000; font-family: Times New Roman; font-size: 13px">Form
of Stock Option Award under ENDRA Life Sciences Inc. 2016 Omnibus
Incentive Plan (incorporated by reference to Exhibit 10.5 to
Amendment No. 1 to the Registrant&#x2019;s Registration Statement on
Form S-1 (File No. 333-214724) filed on December 6,
2016)</font></div>
</div>
</div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
<div style="display: table">
<div style="display: table-row">
<div style="display: table-cell; width: 96px"><font style="color: rgb(50, 99, 236);"><a href="http://www.sec.gov/Archives/edgar/data/1681682/000165495416004599/end_ex106.htm">
<font style="font-family: Times New Roman; font-size: 13px">4.7</font></a></font></div>
<div style="text-align: left; display: table-cell"><font style="color: #000000; font-family: Times New Roman; font-size: 13px">Form
of Restricted Stock Unit Award under ENDRA Life Sciences Inc. 2016
Omnibus Incentive Plan (incorporated by reference to Exhibit 10.6
to Amendment No. 1 to the Registrant&#x2019;s Registration Statement
on Form S-1 (File No. 333-214724) filed on December 6,
2016)</font></div>
</div>
</div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
<div style="display: table">
<div style="display: table-row">
<div style="display: table-cell; width: 96px"><font style="color: rgb(50, 99, 236);"><font style="font-family: Times New Roman; font-size: 13px"><a href="ndra_ex51.htm">5.1</a></font></font></div>
<div style="text-align: left; display: table-cell"><font style="color: #000000; font-family: Times New Roman; font-size: 13px">Opinion
of K&amp;L Gates LLP</font></div>
</div>
</div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
<div style="display: table">
<div style="display: table-row">
<div style="display: table-cell; width: 96px"><font style="font-family: Times New Roman; font-size: 13px"><font style="color: rgb(50, 99, 236);"><a href="ndra_ex231.htm">23.1</a></font><br></font></div>
<div style="text-align: left; display: table-cell"><font style="color: #000000; font-family: Times New Roman; font-size: 13px">Consent
of RBSM LLP, Independent Registered Public Accounting
Firm</font></div>
</div>
</div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
<div style="display: table">
<div style="display: table-row">
<div style="display: table-cell; width: 96px"><font style="font-family: Times New Roman; font-size: 13px"><font style="color: rgb(50, 99, 236);"><a href="ndra_ex51.htm">23.2</a></font>&#xA0;&#xA0;&#xA0;&#xA0;&#xA0;&#xA0;&#xA0;&#xA0;&#xA0;&#xA0;&#xA0;&#xA0;&#xA0;&#xA0;&#xA0;&#xA0;&#xA0;&#xA0;&#xA0;&#xA0;&#xA0;&#xA0;&#xA0;</font></div>
<div style="text-align: left; display: table-cell"><font style="color: #000000; font-family: Times New Roman; font-size: 13px">Consent
of K&amp;L Gates LLP (contained in Exhibit 5.1)</font></div>
</div>
</div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
<div style="display: table">
<div style="display: table-row">
<div style="display: table-cell; width: 96px"><font style="font-family: Times New Roman; font-size: 13px"><font style="color: rgb(50, 99, 236);"><a href="#power">24.1</a></font>&#xA0;</font></div>
<div style="text-align: left; display: table-cell"><font style="font-family: Times New Roman; font-size: 13px">Power of Attorney
(included on the signature page of this Registration
Statement)</font></div>
</div>
</div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
<div id="pgbrk" style="width: 100%; margin-left: 0px; text-indent: 0px; margin-right: 0px">
<div id="ftr"><br></div>
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<div id="hdr">
<div style="text-align: left; width: 100%; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</div>
</div>
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; font-family: Times New Roman; font-size: 13px">
</font></div>
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px;">&#xA0;</font></div>
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; font-family: Times New Roman; font-size: 13px">
SIGNATURES</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 48px">
<font style="font-family: Times New Roman; font-size: 13px">Pursuant to the
requirements of the Securities Act, the Registrant certifies that
it has reasonable grounds to believe that it meets all of the
requirements for filing on Form S-8 and has duly caused this
Registration Statement to be signed on its behalf by the
undersigned, thereunto duly authorized, in the City of Ann Arbor,
State of Michigan, on March 25, 2021.</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">

<div>
<table cellpadding="0" cellspacing="0" style="font-family: inherit; font-size: inherit; margin-right:0px;width:100%;margin-left:0px;">
<tr>
<td rowspan="1" style="width: 50%; vertical-align: top;">
<div style="margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-size: 13px; font-family: Times New Roman">&#xA0;</font></div>
</td>
<td colspan="2" rowspan="1" style="vertical-align: bottom; width: 38%;">
<div><font style="font-family: Times New Roman; font-size: 13px">ENDRA Life Sciences
Inc.</font></div>
</td>
<td rowspan="1" style="width: 12%; vertical-align: top;">
<div style="margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-size: 13px; font-family: Times New Roman">&#xA0;</font></div>
</td>
</tr><tr>
<td style="width: 50%; vertical-align: top;">
<div style="margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-size: 13px; font-family: Times New Roman">&#xA0;</font></div>
</td>
<td style="width: 3%; vertical-align: top;">
<div style="margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-size: 13px; font-family: Times New Roman">&#xA0;</font></div>
</td>
<td style="width: 35%; vertical-align: top;">
<div style="margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-size: 13px; font-family: Times New Roman">&#xA0;</font></div>
</td>
<td style="width: 12%; vertical-align: top;">
<div style="margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-size: 13px; font-family: Times New Roman">&#xA0;</font></div>
</td>
</tr><tr>
<td style="vertical-align: top; width: 50%; border-bottom: medium solid rgb(255, 255, 255);">
<br></td>
<td style="vertical-align: top; width: 3%; border-bottom: medium solid rgb(255, 255, 255);">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px"><font style="font-size: 13px; font-family: Times New Roman">By:&#xA0;&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 35%; border-bottom: 2px solid black; white-space: nowrap;">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px"><font style="font-size: 13px; font-family: Times New Roman">/s/ <font style="font-family: Times New Roman; font-size: 13px">Francois
Michelon</font></font></div>
</td>
<td style="vertical-align: top; width: 12%; border-bottom: medium solid rgb(255, 255, 255);">
<div style="margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-size: 13px; font-family: Times New Roman">&#xA0;</font></div>
</td>
</tr><tr>
<td style="width: 50%; vertical-align: top;">
<div style="margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-size: 13px; font-family: Times New Roman">&#xA0;</font></div>
</td>
<td style="width: 3%; vertical-align: top;">
<div style="margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-size: 13px; font-family: Times New Roman">&#xA0;</font></div>
</td>
<td style="vertical-align: bottom; width: 35%; white-space: nowrap;">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px"><font style="font-size: 13px; font-family: Times New Roman"><font style="font-family: Times New Roman; font-size: 13px">Francois
Michelon</font>&#xA0;</font></div>
</td>
<td style="width: 12%; vertical-align: top;">
<div style="margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-size: 13px; font-family: Times New Roman">&#xA0;</font></div>
</td>
</tr><tr>
<td style="width: 50%; vertical-align: top;">
<div style="margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-size: 13px; font-family: Times New Roman">&#xA0;</font></div>
</td>
<td style="width: 3%; vertical-align: top;">
<div style="margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-size: 13px; font-family: Times New Roman">&#xA0;</font></div>
</td>
<td style="width: 35%; vertical-align: top;">
<div style="margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-size: 13px; font-family: Times New Roman"><font style="font-family: Times New Roman; font-size: 13px">Chief Executive
Officer</font>&#xA0;</font></div>
</td>
<td style="width: 12%; vertical-align: top;">
<div style="margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-size: 13px; font-family: Times New Roman">&#xA0;</font></div>
</td>
</tr></table>
</div>
&#xA0;&#xA0;</div>
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px;">
<font style="font-weight: bold; font-family: Times New Roman; font-size: 13px"><a name="power">P</a>OWER OF ATTORNEY</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 48px">
<font style="font-family: Times New Roman; font-size: 13px">Each
person whose signature appears below constitutes and appoints
Francois Michelon and David R. Wells, and each of them, his true
and lawful attorney-in-fact and agent, each with full power of
substitution and resubstitution, severally, for him and in his
name, place and stead, in any and all capacities, to sign any and
all amendments (including post-effective amendments) to this
Registration Statement on Form S-8, and to file the same, with all
exhibits thereto and other documents in connection therewith, with
the Securities and Exchange Commission, granting unto said
attorneys-in-fact and agents, and each of them, full power and
authority to do and perform each and every act and thing requisite
and necessary to be done in and about the premises, as fully to all
intents and purposes as he might or could do in person, hereby
ratifying and confirming all that said attorneys-in-fact and
agents, or any of them or their or his or her substitute or
substitutes, may lawfully do or cause to be done by virtue hereof.
This power of attorney may be executed in
counterparts.</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 48px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="color: #000000">Pursuant to the requirements of the Securities
Act, this Registration Statement has been signed below by the
following persons in the capacities indicated, in each case on
March</font> 25, 2021<font style="color: #000000">:</font></font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
<div>
<table cellpadding="0" cellspacing="0" style="width: 100%; font-family: Times New Roman; font-size: 13px">
<tr>
<td style="vertical-align: top; width: 37%;">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; font-family: Times New Roman; font-size: 13px">
<font style="text-decoration: underline">Signature</font></font></div>
</td>
<td style="vertical-align: top; width: 14%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 50%;">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; font-family: Times New Roman; font-size: 13px">
<font style="text-decoration: underline">Title</font></font></div>
</td>
</tr><tr>
<td style="vertical-align: bottom; width: 37%; border-bottom: 2px solid #000000">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">/s/
Francois
Michelon&#xA0;&#xA0;&#xA0;&#xA0;&#xA0;&#xA0;&#xA0;&#xA0;&#xA0;&#xA0;&#xA0;&#xA0;&#xA0;&#xA0;&#xA0;&#xA0;&#xA0;&#xA0;&#xA0;&#xA0;&#xA0;&#xA0;&#xA0;&#xA0;&#xA0;&#xA0;&#xA0;&#xA0;&#xA0;&#xA0;&#xA0;&#xA0;&#xA0;&#xA0;&#xA0;&#xA0;&#xA0;&#xA0;&#xA0;&#xA0;&#xA0;&#xA0;&#xA0;&#xA0;&#xA0;&#xA0;&#xA0;&#xA0;&#xA0;&#xA0;&#xA0;&#xA0;&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 14%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 50%">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">Chief
Executive Officer and Director</font></div>
</td>
</tr><tr>
<td style="vertical-align: top; width: 37%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">Francois
Michelon</font></div>
</td>
<td style="vertical-align: top; width: 14%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 50%">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">(Principal
Executive Officer)</font></div>
</td>
</tr><tr>
<td style="vertical-align: top; width: 37%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 14%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 50%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
</tr><tr>
<td style="vertical-align: top; width: 37%; border-bottom: 2px solid #000000">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">/s/
David R. Wells&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 14%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 50%">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">Chief
Financial Officer</font></div>
</td>
</tr><tr>
<td style="vertical-align: top; width: 37%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">David
R. Wells</font></div>
</td>
<td style="vertical-align: top; width: 14%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 50%">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">(Principal
Financial Officer and Principal Accounting Officer)</font></div>
</td>
</tr><tr>
<td style="vertical-align: top; width: 37%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 14%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 50%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
</tr><tr>
<td style="vertical-align: top; width: 37%; border-bottom: 2px solid #000000">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">/s/
Louis J.
Basenese&#xA0;&#xA0;&#xA0;&#xA0;&#xA0;&#xA0;&#xA0;&#xA0;&#xA0;&#xA0;&#xA0;&#xA0;&#xA0;&#xA0;&#xA0;&#xA0;&#xA0;&#xA0;&#xA0;&#xA0;&#xA0;&#xA0;&#xA0;&#xA0;&#xA0;&#xA0;&#xA0;&#xA0;&#xA0;&#xA0;&#xA0;&#xA0;&#xA0;&#xA0;&#xA0;&#xA0;&#xA0;&#xA0;&#xA0;&#xA0;&#xA0;&#xA0;&#xA0;&#xA0;&#xA0;&#xA0;&#xA0;&#xA0;&#xA0;&#xA0;&#xA0;&#xA0;&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 14%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 50%">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">Director</font></div>
</td>
</tr><tr>
<td style="vertical-align: top; width: 37%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">Louis
J. Basenese</font></div>
</td>
<td style="vertical-align: top; width: 14%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 50%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
</tr><tr>
<td style="vertical-align: top; width: 37%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 14%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 50%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
</tr><tr>
<td style="vertical-align: top; width: 37%; border-bottom: 2px solid #000000">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">/s/
Anthony DiGiandomenico&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 14%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 50%">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">Director</font></div>
</td>
</tr><tr>
<td style="vertical-align: top; width: 37%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">Anthony
DiGiandomenico</font></div>
</td>
<td style="vertical-align: top; width: 14%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 50%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
</tr><tr>
<td style="vertical-align: top; width: 37%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 14%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 50%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
</tr><tr>
<td style="vertical-align: top; width: 37%; border-bottom: 2px solid #000000">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">/s/
Michael Harsh&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 14%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 50%">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">Director</font></div>
</td>
</tr><tr>
<td style="vertical-align: top; width: 37%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">Michael
Harsh</font></div>
</td>
<td style="vertical-align: top; width: 14%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 50%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
</tr><tr>
<td style="vertical-align: top; width: 37%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 14%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 50%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
</tr><tr>
<td style="vertical-align: top; width: 37%; border-bottom: 2px solid #000000">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">/s/
Alexander
Tokman&#xA0;&#xA0;&#xA0;&#xA0;&#xA0;&#xA0;&#xA0;&#xA0;&#xA0;&#xA0;&#xA0;&#xA0;&#xA0;&#xA0;&#xA0;&#xA0;&#xA0;&#xA0;&#xA0;&#xA0;&#xA0;&#xA0;&#xA0;&#xA0;&#xA0;&#xA0;&#xA0;&#xA0;&#xA0;&#xA0;&#xA0;&#xA0;&#xA0;&#xA0;&#xA0;&#xA0;&#xA0;&#xA0;&#xA0;&#xA0;&#xA0;&#xA0;&#xA0;&#xA0;&#xA0;&#xA0;&#xA0;&#xA0;&#xA0;&#xA0;&#xA0;&#xA0;&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 14%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 50%">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">Director</font></div>
</td>
</tr><tr>
<td style="vertical-align: top; width: 37%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">Alexander
Tokman</font></div>
</td>
<td style="vertical-align: top; width: 14%">
<div><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
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[{"type": "S-8", "sequence": "1", "filename": "ndra_s8.htm", "description": "FORM S-8", "secsgml_size_bytes": 68716}]
{"company-data": {"conformed-name": "ENDRA Life Sciences Inc.", "cik": "0001681682", "assigned-sic": "3845", "irs-number": "260579295", "state-of-incorporation": "DE", "fiscal-year-end": "1231"}, "filing-values": {"form-type": "S-8", "act": "33", "file-number": "333-254713", "film-number": "21773454"}, "business-address": {"street1": "3600 GREEN COURT", "street2": "SUITE 350", "city": "ANN ARBOR", "state": "MI", "zip": "48105", "phone": "734-335-0468"}, "mail-address": {"street1": "3600 GREEN COURT", "street2": "SUITE 350", "city": "ANN ARBOR", "state": "MI", "zip": "48105"}, "former-company": {"former-conformed-name": "Endra Inc.", "date-changed": "20160805"}}
ndra_s8
As
filed with the Securities and Exchange Commission on March 25,
2021
Registration
No. 333-
UNITED STATES
SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM S-8
REGISTRATION STATEMENT UNDER THE SECURITIES ACT OF
1933
ENDRA LIFE SCIENCES INC.
(Exact
name of registrant as specified in its charter)
Delaware
26-0579295
(State
or other jurisdiction of incorporation or
organization)
(I.R.S.
Employer Identification No.)
3600 Green Court, Suite 350
Ann Arbor, MI
48105
(Address
of principal executive offices)
(Zip
Code)
ENDRA Life Sciences Inc. 2016 Omnibus Incentive Plan
(Full
title of the plan)
Francois Michelon
Chief Executive Officer
ENDRA Life Sciences Inc.
3600 Green Court, Suite 350
Ann Arbor, MI 48105
(Name
and address of agent for service)
(734) 335-0468
(Telephone
number, including area code,
of
agent for service)
Indicate by check
mark whether the registrant is a large accelerated filer, an
accelerated filer, a non-accelerated filer, a smaller reporting
company or an emerging growth company. See the definitions of
"large accelerated filer," "accelerated
filer," "smaller reporting company" and
"emerging growth company" in Rule 12b-2 of the Exchange
Act.
Large
accelerated filer
☐
Accelerated
filer
☐
Non-accelerated
filer
☑
Smaller
reporting company
☑
Emerging
growth company
☑
If an emerging
growth company, indicate by check mark if the registrant has
elected not to use the extended transition period for complying
with any new or revised financial accounting standards pursuant to
Section 7(a)(2)(B) of the Securities Act. □
CALCULATION OF
REGISTRATION FEE
Title
of Securities to
be
Registered
Amount
to
be
Registered
(1)
Proposed
Maximum
Offering
Price
Per Share
(2)
Proposed
Maximum
Aggregate
Offering
Price
Amount
of
Registration
Fee
Common Stock,
$0.0001 par value per share, to be issued under the
Registrant's 2016 Omnibus Incentive Plan
1,599,570
(3)
$
2.73
$
4,366,826.10
$
476.42
(1) In
addition, pursuant to Rule 416(a), this Registration Statement also
covers such indeterminate number of additional shares of Common
Stock as is necessary to eliminate any dilutive effect of any
future stock split, stock dividend or similar
transaction.
(2)
Estimated solely for the purpose of calculating the registration
fee pursuant to Rule 457(c) and 457(h) of the Securities Act of
1933, as amended, and based on the average of the high and low
prices for the Registrant's Common Stock on March 22, 2021,
as reported on The Nasdaq Capital Market.
(3)
Represents 1,599,570 additional shares of Common Stock that were
automatically added to the shares authorized for issuance
under the Registrant's 2016 Omnibus Incentive Plan, as
amended (the "Plan"), on January 1, 2021 pursuant to an
annual "evergreen" increase provision contained in the
Plan. Pursuant to such provision, the number of shares reserved for
issuance under the Plan
automatically increases on each January 1 by
the lesser of (a) the number of shares necessary such that the
aggregate number of shares available under the Plan equals 25% of
the number of fully-diluted outstanding shares on the increase date
(assuming the conversion of all outstanding shares of preferred
stock and other outstanding convertible securities and the exercise
of all outstanding options and warrants to purchase shares), and
(b) a number of shares determined by the Registrant's board
of directors.
EXPLANATORY NOTE
This
Registration Statement on Form S-8 is being filed to register an
additional 1,599,570 shares of Common Stock under the ENDRA Life
Sciences Inc. 2016 Omnibus Incentive Plan, as amended (the
"Plan"), as a result of an evergreen provision in the
Plan providing that the total number of shares of Common Stock
reserved for issuance under the Plan is automatically increased as
of each January 1.
These
additional shares of Common Stock are securities of the same class
as other securities for which the Registration Statements on Form
S-8 (File Nos. 333-218894, 333-233178 and 333-237415) (the
"Prior Registration Statements") were filed with the
Securities and Exchange Commission (the "Commission")
on June 21, 2017, August 9, 2019 and March 26, 2020, respectively.
In accordance with Instruction E of Form S-8, the content of the
Prior Registration Statements are incorporated herein by reference
and made a part of this Registration Statement on Form
S-8.
PART I
INFORMATION REQUIRED IN THE SECTION 10(a) PROSPECTUS
Item
1. Plan Information.
The
information required by this Item 1 is omitted from this
registration statement in accordance with Rule 428(b)(1) of the
Securities Act of 1933, as amended (the "Securities
Act"), and the Note to Part I of Form S-8.
Item
2. Registrant Information and Employee Plan Annual
Information.
The
information required by this Item 2 is omitted from this
registration statement in accordance with Rule 428(b)(1) of the
Securities Act and the Note to Part I of Form S-8.
PART II
INFORMATION REQUIRED IN THE REGISTRATION STATEMENT
Item
3. Incorporation of Documents by Reference.
The
following documents have been filed by ENDRA Life Sciences Inc.
(the "Registrant") with the Commission and are
incorporated herein by reference:
●
Annual Report on
Form 10-K for the fiscal year ended December 31, 2020, filed with
the Commission on March 25, 2021;
●
Current Reports on
Form 8-K, filed with the Commission on February 3, 2021 and
February 19, 2021; and
●
The description of
the Registrant's Common Stock contained in the
Registrant's Registration Statement on Form S-1, originally
filed with the Commission on November 21, 2016, as amended (File
No. 333-214724), which description is incorporated by reference
into the Registrant's Registration Statement on Form 8-A,
originally filed with the Commission pursuant to Section 12(g) of
the Exchange Act on December 16, 2016 (File No. 001-37969),
including any further amendment or report filed hereafter for the
purpose of updating such description.
All
reports and other documents filed by the Registrant pursuant to
Sections 13(a), 13(c), 14 or 15(d) of the Exchange Act after the
date hereof, and prior to the filing of a post-effective amendment
which indicates that all securities offered hereby have been sold
or which deregisters all securities then remaining unsold, shall be
deemed to be incorporated by reference herein and to be part hereof
from the date of filing of such reports and documents. The
Registrant is not incorporating by reference any reports or
documents or portions thereof that are not considered to be
"filed" with the Commission.
Any
statement contained herein or in a document incorporated or deemed
to be incorporated herein by reference shall be deemed to be
modified or superseded for purposes of this Registration Statement
to the extent that a statement contained herein or in any other
subsequently filed document which also is or is deemed to be
incorporated herein by reference modifies or supersedes such
earlier statement. Any statement so modified or superseded shall
not be deemed, except as so modified or superseded, to constitute a
part of this Registration Statement.
Item
8. Exhibits.
Exhibit
Number
Description
4.1
Fourth
Amended and Restated Certificate of Incorporation of ENDRA Life
Sciences Inc. (incorporated by reference to Exhibit 3.2 to the
Registrant's Current Report on Form 8-K filed on May 12,
2017)
4.2
Certificate
of Amendment to the Fourth Amended and Restated Certificate of
Incorporation of the Company (incorporated by reference to Exhibit
3.1 to the Registrant's Current Report on Form 8-K filed on
June 18, 2020)
4.3
Amended
and Restated Bylaws of ENDRA Life Sciences Inc. (incorporated by
reference to Exhibit 3.4 to Amendment No. 1 to the
Registrant's Registration Statement on Form S-1 (File No.
333-214724) filed on December 6, 2016)
4.4
ENDRA
Life Sciences Inc. 2016 Omnibus Incentive Plan (incorporated by
reference to Exhibit 10.4 to Amendment No. 1 to the
Registrant's Registration Statement on Form S-1 (File No.
333-214724) filed on December 6, 2016)
4.5
First
Amendment to ENDRA Life Sciences Inc. 2016 Omnibus Incentive Plan
(incorporated by reference to Appendix A to the Registrant's
Definitive Proxy Statement filed on May 10, 2018)
4.6
Form
of Stock Option Award under ENDRA Life Sciences Inc. 2016 Omnibus
Incentive Plan (incorporated by reference to Exhibit 10.5 to
Amendment No. 1 to the Registrant's Registration Statement on
Form S-1 (File No. 333-214724) filed on December 6,
2016)
4.7
Form
of Restricted Stock Unit Award under ENDRA Life Sciences Inc. 2016
Omnibus Incentive Plan (incorporated by reference to Exhibit 10.6
to Amendment No. 1 to the Registrant's Registration Statement
on Form S-1 (File No. 333-214724) filed on December 6,
2016)
5.1
Opinion
of K&L Gates LLP
23.1
Consent
of RBSM LLP, Independent Registered Public Accounting
Firm
23.2
Consent
of K&L Gates LLP (contained in Exhibit 5.1)
24.1
Power of Attorney
(included on the signature page of this Registration
Statement)
SIGNATURES
Pursuant to the
requirements of the Securities Act, the Registrant certifies that
it has reasonable grounds to believe that it meets all of the
requirements for filing on Form S-8 and has duly caused this
Registration Statement to be signed on its behalf by the
undersigned, thereunto duly authorized, in the City of Ann Arbor,
State of Michigan, on March 25, 2021.
ENDRA Life Sciences
Inc.
By:
/s/
Francois
Michelon
Francois
Michelon
Chief Executive
Officer
P
OWER OF ATTORNEY
Each
person whose signature appears below constitutes and appoints
Francois Michelon and David R. Wells, and each of them, his true
and lawful attorney-in-fact and agent, each with full power of
substitution and resubstitution, severally, for him and in his
name, place and stead, in any and all capacities, to sign any and
all amendments (including post-effective amendments) to this
Registration Statement on Form S-8, and to file the same, with all
exhibits thereto and other documents in connection therewith, with
the Securities and Exchange Commission, granting unto said
attorneys-in-fact and agents, and each of them, full power and
authority to do and perform each and every act and thing requisite
and necessary to be done in and about the premises, as fully to all
intents and purposes as he might or could do in person, hereby
ratifying and confirming all that said attorneys-in-fact and
agents, or any of them or their or his or her substitute or
substitutes, may lawfully do or cause to be done by virtue hereof.
This power of attorney may be executed in
counterparts.
Pursuant to the requirements of the Securities
Act, this Registration Statement has been signed below by the
following persons in the capacities indicated, in each case on
March
25, 2021
:
Signature
Title
/s/
Francois
Michelon
Chief
Executive Officer and Director
Francois
Michelon
(Principal
Executive Officer)
/s/
David R. Wells
Chief
Financial Officer
David
R. Wells
(Principal
Financial Officer and Principal Accounting Officer)
/s/
Louis J.
Basenese
Director
Louis
J. Basenese
/s/
Anthony DiGiandomenico
Director
Anthony
DiGiandomenico
/s/
Michael Harsh
Director
Michael
Harsh
/s/
Alexander
Tokman
Director
Alexander
Tokman