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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">As filed with the Securities and Exchange
Commission on June 3, 2016</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 4.5in; text-align: right">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 4.5in; text-align: right">Registration No.&nbsp;333-</P>

<!-- Field: Rule-Page --><DIV STYLE="text-align: left; margin-top: 0; margin-bottom: 3pt"><DIV STYLE="font-size: 1pt; border-top: Black 2pt solid; border-bottom: Black 1pt solid; width: 100%">&nbsp;</DIV></DIV><!-- Field: /Rule-Page -->

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>UNITED STATES</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>SECURITIES AND EXCHANGE COMMISSION</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">Washington, D.C. 20549</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">_________________</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>&nbsp;</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><FONT STYLE="font-size: 12pt"><B>FORM S-8</B></FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>&nbsp;</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>REGISTRATION STATEMENT</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>UNDER</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>THE SECURITIES ACT OF 1933</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>_________________</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>&nbsp;</B></P>

<P STYLE="font: 18pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><FONT STYLE="font-size: 14pt"><B>INNOCOLL
HOLDINGS PUBLIC LIMITED COMPANY</B></FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><I>&nbsp;</I></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><I>(Exact Name of Registrant as Specified
in its Charter)</I></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>_________________</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

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    <td style="width: 50%; padding-right: 5.4pt; padding-left: 5.4pt">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><b>Ireland</b></P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><i>(State of Incorporation)</i></P></td>
    <td style="width: 50%; padding-right: 5.4pt; padding-left: 5.4pt">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><b>Not Applicable</b></P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><i>(I.R.S. Employer Identification No.)</i></P></td></tr>
</table>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>&nbsp;</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>Innocoll Holdings plc</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>Unit 9, Block D</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>Monksland Business Park</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>Monksland, Athlone, Co. Roscommon</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>Ireland</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><I>(Address of Principal Executive Offices)</I></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>&nbsp;</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>2016 Omnibus Incentive Compensation Plan</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>Amended and Restated 2015 Stock Option
Plan</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>Certain Amended and Restated Option Agreements</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><I>(Full Title of the Plans)</I></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>&nbsp;</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>Anthony P. Zook</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>3803 West Chester Pike</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>Suite 190</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>Newtown Square, PA 19073</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>(610) 405-2347</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><I>(Name, Address and Telephone Number of
Agent for Service)</I></P>

<table cellspacing="0" cellpadding="0" style="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
<tr style="vertical-align: bottom">
    <td colspan="3" style="padding-right: 5.4pt; padding-left: 5.4pt; font-size: 10pt; layout-grid-mode: line; text-align: center"><font style="font-size: 10pt"><i>_________________</i></font></td></tr>
<tr style="vertical-align: bottom">
    <td style="width: 34%; padding-right: 5.4pt; padding-left: 5.4pt; font-size: 10pt; layout-grid-mode: line; text-align: center">&nbsp;</td>
    <td style="width: 33%; padding-right: 5.4pt; padding-left: 5.4pt; font-size: 10pt; layout-grid-mode: line; text-align: center"><font style="font-size: 10pt"><i>Copies to:</i></font></td>
    <td style="width: 33%; padding-right: 5.4pt; padding-left: 5.4pt; font-size: 10pt; layout-grid-mode: line; text-align: center">&nbsp;</td></tr>
<tr style="vertical-align: bottom">
    <td style="padding-right: 5.4pt; padding-left: 5.4pt; font-size: 10pt; layout-grid-mode: line; text-align: center">&nbsp;</td>
    <td style="padding-right: 5.4pt; padding-left: 5.4pt">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">Jeffrey A. Baumel, Esq.</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">Ilan Katz, Esq.</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">Dentons US LLP</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">1221 Avenue of the Americas</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">New York, New York 10020</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">(212) 768-6700</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><i>_________________</i></P></td>
    <td style="padding-right: 5.4pt; padding-left: 5.4pt; font-size: 10pt; layout-grid-mode: line; text-align: center">&nbsp;</td></tr>
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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Indicate by check mark whether the Registrant is a large accelerated
filer, an accelerated filer, a non-accelerated filer, or smaller reporting company. See the definitions of &ldquo;large accelerated
filer,&rdquo; &ldquo;accelerated filer&rdquo; and &ldquo;smaller reporting company&rdquo; in Rule&nbsp;12b-2 of the Exchange Act.:</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"></P>

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<TR STYLE="vertical-align: bottom">
    <TD STYLE="width: 25%; layout-grid-mode: line">&nbsp;</TD>
    <TD STYLE="width: 3%; layout-grid-mode: line">&nbsp;</TD>
    <TD STYLE="width: 22%; layout-grid-mode: line">&nbsp;</TD>
    <TD STYLE="width: 3%; layout-grid-mode: line">&nbsp;</TD>
    <TD STYLE="width: 22%; layout-grid-mode: line">&nbsp;</TD>
    <TD STYLE="width: 3%; layout-grid-mode: line">&nbsp;</TD>
    <TD STYLE="width: 22%; layout-grid-mode: line">&nbsp;</TD></TR>
<TR>
    <TD STYLE="vertical-align: top; layout-grid-mode: line"><FONT STYLE="font-family: Wingdings; font-size: 10pt">&uml;</FONT><FONT STYLE="font-size: 10pt"> Large accelerated filer </FONT></TD>
    <TD STYLE="vertical-align: bottom; layout-grid-mode: line">&nbsp;</TD>
    <TD STYLE="vertical-align: top; layout-grid-mode: line; text-align: center"><FONT STYLE="font-family: Wingdings; font-size: 10pt">&thorn;</FONT><FONT STYLE="font-size: 10pt"> Accelerated filer </FONT></TD>
    <TD STYLE="vertical-align: bottom; layout-grid-mode: line">&nbsp;</TD>
    <TD STYLE="vertical-align: top; layout-grid-mode: line; text-align: center"><FONT STYLE="font-family: Wingdings; font-size: 10pt">&uml;</FONT><FONT STYLE="font-size: 10pt"> Non-accelerated filer </FONT></TD>
    <TD STYLE="vertical-align: bottom; layout-grid-mode: line">&nbsp;</TD>
    <TD NOWRAP STYLE="vertical-align: top; layout-grid-mode: line; text-align: center"><FONT STYLE="font-family: Wingdings; font-size: 10pt">&uml;</FONT><FONT STYLE="font-size: 10pt"> Smaller reporting company</FONT></TD></TR>
</TABLE>


<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">________________</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>&nbsp;</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>CALCULATION OF REGISTRATION FEE</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>&nbsp;</B></P>

<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="border-collapse: collapse; width: 100%; font: 10pt Times New Roman, Times, Serif">
<TR STYLE="vertical-align: bottom">
    <TD NOWRAP STYLE="font-weight: bold; text-align: center; border-bottom: Black 1pt solid"><FONT STYLE="font-size: 8pt"><B>Title&nbsp;of&nbsp;Securities</B><br>
    <B>to&nbsp;be&nbsp;Registered<FONT STYLE="font-family: Times New Roman, Times, Serif"><SUP>(1)</SUP></FONT></B></FONT></TD><TD NOWRAP STYLE="font-weight: bold; padding-bottom: 1pt"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD>
    <TD COLSPAN="2" NOWRAP STYLE="font-weight: bold; text-align: center; border-bottom: Black 1pt solid"><FONT STYLE="font-size: 8pt"><B>Amount&nbsp;to</B><br>
    <B>be</B><br> <B>Registered<SUP>(2)</SUP></B></FONT></TD><TD NOWRAP STYLE="padding-bottom: 1pt; font-weight: bold"><FONT STYLE="font-size: 8pt"><SUP>&nbsp;</SUP></FONT></TD><TD NOWRAP STYLE="font-weight: bold; padding-bottom: 1pt"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD>
    <TD COLSPAN="2" NOWRAP STYLE="font-weight: bold; text-align: center; border-bottom: Black 1pt solid"><FONT STYLE="font-size: 8pt"><B>Proposed</B><br>
    <B>Maximum</B><br> <B>Offering</B><br> <B>Price&nbsp;Per</B><br> <B>Share<SUP>(3)</SUP></B></FONT></TD><TD NOWRAP STYLE="padding-bottom: 1pt; font-weight: bold"><FONT STYLE="font-size: 8pt"><SUP>&nbsp;</SUP></FONT></TD><TD NOWRAP STYLE="font-weight: bold; padding-bottom: 1pt"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD>
    <TD COLSPAN="2" NOWRAP STYLE="font-weight: bold; text-align: center; border-bottom: Black 1pt solid"><FONT STYLE="font-size: 8pt"><B>Proposed</B></FONT><br>
<FONT STYLE="font-size: 8pt"><B>Maximum</B></FONT><br><FONT STYLE="font-size: 8pt"> <B>Aggregate</B></FONT><br><FONT STYLE="font-size: 8pt">
<B>Offering&nbsp;Price<SUP>(3)</SUP></B></FONT></TD><TD NOWRAP STYLE="padding-bottom: 1pt; font-weight: bold"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD><TD NOWRAP STYLE="font-weight: bold; padding-bottom: 1pt"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD>
    <TD COLSPAN="2" NOWRAP STYLE="font-weight: bold; text-align: center; border-bottom: Black 1pt solid"><FONT STYLE="font-size: 8pt">Amount&nbsp;of<BR>
    Registration<BR> Fee</FONT></TD><TD NOWRAP STYLE="padding-bottom: 1pt; font-weight: bold"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD></TR>
<TR STYLE="vertical-align: bottom; background-color: rgb(204,238,255)">
    <TD STYLE="width: 48%; font-weight: bold; text-align: left">2016 Omnibus Incentive Compensation Plan</TD><TD STYLE="width: 1%">&nbsp;</TD>
    <TD STYLE="width: 1%; text-align: left">&nbsp;</TD><TD STYLE="width: 10%; text-align: right">1,480,993</TD><TD STYLE="width: 1%; text-align: left"><SUP>(4)</SUP></TD><TD STYLE="width: 1%">&nbsp;</TD>
    <TD STYLE="width: 1%; text-align: left">$</TD><TD STYLE="width: 10%; text-align: right">10.50</TD><TD STYLE="width: 1%; text-align: left"><SUP>(8)</SUP></TD><TD STYLE="width: 1%">&nbsp;</TD>
    <TD STYLE="width: 1%; text-align: left">$</TD><TD STYLE="width: 10%; text-align: right">15,550,426.50</TD><TD STYLE="width: 1%; text-align: left">&nbsp;</TD><TD STYLE="width: 1%">&nbsp;</TD>
    <TD STYLE="width: 1%; text-align: left">$</TD><TD STYLE="width: 10%; text-align: right">1,565.93</TD><TD STYLE="width: 1%; text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: White">
    <TD STYLE="font-weight: bold; text-align: left">2016 Omnibus Incentive Compensation Plan</TD><TD>&nbsp;</TD>
    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">1,369,007</TD><TD STYLE="text-align: left"><SUP>(5)</SUP></TD><TD>&nbsp;</TD>
    <TD STYLE="text-align: left">$</TD><TD STYLE="text-align: right">8.50</TD><TD STYLE="text-align: left"><SUP>(9)</SUP></TD><TD>&nbsp;</TD>
    <TD STYLE="text-align: left">$</TD><TD STYLE="text-align: right">11,636,559.50</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
    <TD STYLE="text-align: left">$</TD><TD STYLE="text-align: right">1,171.80</TD><TD STYLE="text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: rgb(204,238,255)">
    <TD STYLE="font-weight: bold; text-align: left">Amended and Restated 2015 Stock Option Plan</TD><TD>&nbsp;</TD>
    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">1,194,407</TD><TD STYLE="text-align: left"><SUP>(6)</SUP></TD><TD>&nbsp;</TD>
    <TD STYLE="text-align: left">$</TD><TD STYLE="text-align: right">10.92</TD><TD STYLE="text-align: left"><SUP>(10)</SUP></TD><TD>&nbsp;</TD>
    <TD STYLE="text-align: left">$</TD><TD STYLE="text-align: right">13,042,924.44</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
    <TD STYLE="text-align: left">$</TD><TD STYLE="text-align: right">1,313.42</TD><TD STYLE="text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: White">
    <TD STYLE="font-weight: bold; text-align: left; padding-bottom: 1pt">Certain Amended and Restated Option Agreements</TD><TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
    <TD STYLE="border-bottom: Black 1pt solid; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 1pt solid; text-align: right">328,388</TD><TD STYLE="padding-bottom: 1pt; text-align: left"><SUP>(7)</SUP></TD><TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
    <TD STYLE="border-bottom: Black 1pt solid; text-align: left">$</TD><TD STYLE="border-bottom: Black 1pt solid; text-align: right">9.00</TD><TD STYLE="padding-bottom: 1pt; text-align: left"><SUP>(11)</SUP></TD><TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
    <TD STYLE="border-bottom: Black 1pt solid; text-align: left">$</TD><TD STYLE="border-bottom: Black 1pt solid; text-align: right">2,955,492.00</TD><TD STYLE="padding-bottom: 1pt; text-align: left">&nbsp;</TD><TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
    <TD STYLE="border-bottom: Black 1pt solid; text-align: left">$</TD><TD STYLE="border-bottom: Black 1pt solid; text-align: right">297.62</TD><TD STYLE="padding-bottom: 1pt; text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: rgb(204,238,255)">
    <TD STYLE="font-weight: bold; padding-bottom: 1pt">Total</TD><TD STYLE="font-weight: bold; padding-bottom: 1pt">&nbsp;</TD>
    <TD STYLE="border-bottom: Black 1pt solid; font-weight: bold; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 1pt solid; font-weight: bold; text-align: right">4,372,795</TD><TD STYLE="padding-bottom: 1pt; font-weight: bold; text-align: left"><SUP>&nbsp;</SUP></TD><TD STYLE="font-weight: bold; padding-bottom: 1pt">&nbsp;</TD>
    <TD STYLE="border-bottom: Black 1pt solid; font-weight: bold; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 1pt solid; font-weight: bold; text-align: right"><font style="font-size: 10pt"><b>N/A</b></font></TD><TD STYLE="padding-bottom: 1pt; font-weight: bold; text-align: left"><SUP>&nbsp;</SUP></TD><TD STYLE="font-weight: bold; padding-bottom: 1pt">&nbsp;</TD>
    <TD STYLE="border-bottom: Black 1pt solid; font-weight: bold; text-align: left">$</TD><TD STYLE="border-bottom: Black 1pt solid; font-weight: bold; text-align: right">43,185,402.44</TD><TD STYLE="padding-bottom: 1pt; font-weight: bold; text-align: left">&nbsp;</TD><TD STYLE="font-weight: bold; padding-bottom: 1pt">&nbsp;</TD>
    <TD STYLE="border-bottom: Black 1pt solid; font-weight: bold; text-align: left">$</TD><TD STYLE="border-bottom: Black 1pt solid; font-weight: bold; text-align: right">4,348.77</TD><TD STYLE="padding-bottom: 1pt; font-weight: bold; text-align: left">&nbsp;</TD></TR>
</TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.3in; text-align: justify; text-indent: -0.3in">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0"></TD><TD STYLE="width: 0.3in">(1)</TD><TD STYLE="text-align: justify">Ordinary shares, $0.01 par value per share (&ldquo;Ordinary Shares&rdquo;), of Innocoll Holdings
plc (&ldquo;Innocoll&rdquo;).</TD></TR></TABLE>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0"></TD><TD STYLE="width: 0.3in">(2)</TD><TD STYLE="text-align: justify">Pursuant to Rule 416(a), this Registration Statement also covers any additional securities that
may be offered or issued in connection with any stock split, stock dividend or similar transaction.</TD></TR></TABLE>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0"></TD><TD STYLE="width: 0.3in">(3)</TD><TD STYLE="text-align: justify">Estimated in accordance with Rule 457(h) solely for the purpose of calculating the registration
fee.</TD></TR></TABLE>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0"></TD><TD STYLE="width: 0.3in">(4)</TD><TD STYLE="text-align: justify">Represents Ordinary Shares that may be issued pursuant to the Innocoll 2016 Omnibus Incentive Compensation
Plan.</TD></TR></TABLE>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0"></TD><TD STYLE="width: 0.3in">(5)</TD><TD STYLE="text-align: justify">Represents Ordinary Shares issuable pursuant to outstanding but unexercised options previously
granted under the 2016 Omnibus Incentive Compensation Plan.</TD></TR></TABLE>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0"></TD><TD STYLE="width: 0.3in">(6)</TD><TD STYLE="text-align: justify">Represents Ordinary Shares issuable pursuant to outstanding but unexercised options previously
granted under the Amended and Restated 2015 Stock Option Plan.</TD></TR></TABLE>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0"></TD><TD STYLE="width: 0.3in">(7)</TD><TD STYLE="text-align: justify">Represents Ordinary Shares issuable pursuant to outstanding but unexercised options previously
granted to certain former or current employees of Innocoll.</TD></TR></TABLE>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0"></TD><TD STYLE="width: 0.3in">(8)</TD><TD STYLE="text-align: justify">With respect to the 1,480,993 Ordinary Shares that are authorized under the 2016 Omnibus Incentive
Compensation Plan (excluding shares issuable under outstanding options), estimated solely for the purpose of calculating the registration
fee in accordance with Rule 457(h), based upon the average of the high and low prices of the Ordinary Shares reported on the NASDAQ
Global Market on May 26, 2016 of $10.50.</TD></TR></TABLE>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0"></TD><TD STYLE="width: 0.3in">(9)</TD><TD STYLE="text-align: justify">With respect to the 1,369,007 Ordinary Shares that are issuable upon exercise of currently outstanding
awards under the 2016 Omnibus Incentive Compensation Plan, estimated in accordance with Rule 457(h) solely for the purpose of calculating
the registration fee on the basis of the weighted average option exercise price of $8.50 per share.</TD></TR></TABLE>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0"></TD><TD STYLE="width: 0.3in">(10)</TD><TD STYLE="text-align: justify">With respect to the 1,194,407 Ordinary Shares that are issuable upon exercise of currently outstanding
awards under the Amended and Restated 2015 Stock Option Plan, estimated in accordance with Rule 457(h) solely for the purpose of
calculating the registration fee on the basis of the weighted average option exercise price of $10.92 per share.</TD></TR></TABLE>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0"></TD><TD STYLE="width: 0.3in">(11)</TD><TD STYLE="text-align: justify">With respect to the 328,388 Ordinary Shares that are issuable upon exercise of currently outstanding
awards issued to certain former or current employees of Innocoll, estimated in accordance with Rule 457(h) solely for the purpose
of calculating the registration fee on the basis of the weighted average option exercise price of $9.00 per share.</TD></TR></TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>&nbsp;</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B></B></P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B></B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>&nbsp;</B></P>


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    <DIV STYLE="page-break-before: always; margin-top: 6pt; margin-bottom: 12pt"><P STYLE="margin: 0pt">&nbsp;</P></DIV>
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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>&nbsp;</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>EXPLANATORY NOTE </B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B>&nbsp;</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.5in">Innocoll Holdings plc
(&ldquo;we&rdquo; or the &ldquo;Registrant&rdquo;) has prepared this Registration Statement in accordance with the requirements
of Form S-8 under the Securities Act of 1933, as amended (the &ldquo;Securities Act&rdquo;). This Registration Statement registers
4,372,795 of our ordinary shares, par value $0.01 per share (&ldquo;Ordinary Shares&rdquo;) which may be issued from time to time
to: (i) recipients of future awards under our 2016 Omnibus Incentive Compensation Plan; (ii) holders of outstanding awards issued
under our 2016 Omnibus Incentive Compensation Plan; (iii) holders of outstanding awards issued under our Amended and Restated 2015
Stock Option Plan; and (iv) Gordon Dunn, Paul Oxholm, Michael Myers, Dennis Langer, Denise Carter, David Prior, Alex Dietrich,
James Croke, Turlough O&rsquo; Connor, Pauline Ogle and Aaron Wyse upon the exercise of options granted to such individuals pursuant
to certain Amended and Restated Option Agreements.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>&nbsp;</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>PART I</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>&nbsp;</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>INFORMATION REQUIRED IN THE SECTION 10(a)
PROSPECTUS</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.5in">The documents containing
the information specified in Part I of Form S-8 will be sent or given to participants in the plans or arrangements as specified
by Rule 428(b)(1) under the Securities Act. In accordance with Rule 428 and the requirements of Part I of Form S-8, such documents
are not required to be and are not filed with the Securities and Exchange Commission (the &ldquo;Commission&rdquo;) either as part
of this Registration Statement or as prospectuses or prospectus supplements pursuant to Rule 424 under the Securities Act. These
documents and the documents incorporated by reference in this Registration Statement pursuant to Item 3 of Part II of this Form
S-8, taken together, constitute a prospectus that meets the requirements of Section 10(a) of the Securities Act.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>&nbsp;</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>PART II</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>&nbsp;</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>INFORMATION REQUIRED IN THE REGISTRATION
STATEMENT</B></P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 27pt; text-indent: 0in">&nbsp;</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 27pt; text-indent: 0in">Item 3.&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;INCORPORATION
OF DOCUMENTS BY REFERENCE.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.5in">The following documents,
which we have filed with the Securities and Exchange Commission (the &ldquo;Commission&rdquo;) are hereby incorporated
by reference into this Registration Statement:</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.75in; text-align: justify; text-indent: -0.25in">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.5in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD STYLE="text-align: justify">Our Annual Report on Form 20-F for the year ended December 31, 2015 filed with the Commission on
March 17, 2016;</TD></TR></TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.75in; text-align: justify; text-indent: -0.25in">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.5in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD STYLE="text-align: justify">Our
                                         Current Reports on Form 6-K filed with the Commission on March 3, 2016, April
                                         27, 2016, May 25, 2016 (excluding Exhibit 99.2 thereto) and May 31, 2016; and</TD></TR></TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.75in; text-align: justify; text-indent: -0.25in">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.5in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD STYLE="text-align: justify">The description of our ordinary shares contained in our Current Report on Form 6-K using the EDGAR
format type 8-K12B filed with the Commission on March 16, 2016, which incorporates such description of our ordinary shares by reference
to our Registration Statement Form F-4 (File No. 333-208438), as filed with the Commission on December 10, 2015 and amended on
December 22, 2015 as and declared effective by the Commission on December 22, 2015.</TD></TR></TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.5in">All documents filed
by us pursuant to Sections&nbsp;13(a), 13(c), 14 and 15(d) of the Securities Exchange Act of 1934 (the &ldquo;Exchange Act&rdquo;)
on or after the date of this Registration Statement and prior to the filing of a post-effective amendment to this Registration
Statement which indicates that all securities registered hereby have been sold or which deregisters such securities then remaining
unsold shall be deemed to be incorporated by reference in this Registration Statement and to be a part hereof from the date of
filing of such documents, except for information furnished to the SEC that is not deemed to be &ldquo;filed&rdquo; for purposes
of the Exchange Act (such documents, and the documents listed above, being hereinafter referred to as &ldquo;Incorporated Documents&rdquo;).
Any statement contained herein or in an Incorporated Document shall be deemed to be modified or superseded for purposes of this
Registration Statement to the extent that a statement contained herein or in any other subsequently filed Incorporated</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.5in">&nbsp;</P>


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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0in">Document modifies or
supersedes such statement. Any such statement so modified or superseded shall not be deemed, except as so modified or superseded,
to constitute a part of this Registration Statement.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 27pt; text-indent: 0in">Item 4. &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;DESCRIPTION
OF SECURITIES.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">Not Applicable. Our Ordinary Shares are
registered pursuant to Section 12(b) of the Exchange Act, and, therefore, the description thereof is omitted.</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 27pt; text-indent: 0in">&nbsp;</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 27pt; text-indent: 0in">Item 5. &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;INTERESTS
OF NAMED EXPERTS AND COUNSEL.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">None.</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 27pt; text-indent: 0in">&nbsp;</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 27pt; text-indent: 0in">Item 6. &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;INDEMNIFICATION
OF BOARD MEMBERS AND OFFICERS.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.5in">To the fullest extent
permitted by Irish law, the constitution of the Registrant confers an indemnity on the Registrant&rsquo;s directors and officers
(each an &ldquo;Indemnified Person&rdquo;) who was or is a party or is threatened to be made a party to any action, suit or proceeding
by reason of the fact that he or she is or was an Indemnified Person against expenses (including legal fees), judgments, fines
and amounts paid in settlement, actually and reasonably incurred by such Indemnified Person in connection with such action, suit
or proceeding (subject to them meeting an applicable standard of conduct). However, this indemnity is limited by the Irish Companies
Act 2014 (the &ldquo;Companies Act&rdquo;), which prescribes that an advance commitment to indemnify only permits a company to
pay the costs or discharge the liability of a director or secretary where judgment is given in favor of the director or secretary
in any civil or criminal action in respect of such costs or liability, where he is acquitted or where an Irish court grants relief
because the director or secretary acted honestly and reasonably and ought fairly to be excused. Any provision whereby an Irish
company seeks to commit in advance to indemnify its directors or secretary over and above the limitations imposed by the Companies
Act will be void under Irish law, whether contained in its articles of association or any contract between the company and the
director or secretary. This restriction does not apply to our executives who are not directors or company secretary and our constitution
also contains indemnification provisions for persons who are not directors or our company secretary.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.5in">We are permitted under
our articles of association and the Companies Act to take out directors&rsquo; and officers&rsquo; liability insurance, as well
as other types of insurance, for our directors, officers, employees and agents.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.5in">One or more of the
Registrant&rsquo;s subsidiaries has or will enter into indemnification agreements with each of the Registrant&rsquo;s directors,
secretary and executive officers (as may be determined by the board of directors of the Registrant from time to time), providing
for the indemnification of, and advancement of expenses to, such persons, to the fullest extent permitted by law.</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 27pt; text-indent: 0in">&nbsp;</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 27pt; text-indent: 0in">Item 7. &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;EXEMPTION FROM
REGISTRATION CLAIMED.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">Not Applicable.</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 27pt; text-indent: 0in">&nbsp;</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 27pt; text-indent: 0in">Item 8. &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;EXHIBITS.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
<tr style="vertical-align: bottom">
    <TD STYLE="width: 10%; border-bottom: Black 1pt solid; padding-right: 0; padding-left: 0; text-align: center; layout-grid-mode: line"><FONT STYLE="font-size: 8pt"><B>Exhibit
    </B><br>
    <B>Number</B></FONT></td>
    <TD STYLE="width: 2%; padding-right: 0; padding-left: 0; text-align: center; text-indent: 0in; layout-grid-mode: line"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></td>
    <TD STYLE="width: 88%; border-bottom: Black 1pt solid; padding-left: 0; text-align: center; text-indent: -11.25pt; layout-grid-mode: line; padding-right: 0"><FONT STYLE="font-size: 8pt"><B>Description
    of Exhibit</B></FONT></td></tr>
<TR STYLE="vertical-align: bottom">
    <TD STYLE="padding-right: 0; padding-left: 0; text-align: center; layout-grid-mode: line">&nbsp;</TD>
    <TD STYLE="padding-right: 0; padding-left: 0; text-align: center; text-indent: 0in; layout-grid-mode: line">&nbsp;</TD>
    <TD STYLE="padding-left: 0; text-align: center; text-indent: -11.25pt; layout-grid-mode: line; padding-right: 0">&nbsp;</TD></TR>
<tr style="vertical-align: top">
    <TD STYLE="padding-right: 0; padding-left: 0; text-align: center; layout-grid-mode: line">&nbsp;<font style="font-size: 10pt">&nbsp;3.1</font></td>
    <TD STYLE="padding-right: 0; padding-left: 0; text-indent: 0in; layout-grid-mode: line">&nbsp;</td>
    <TD STYLE="padding-right: 0; padding-left: 0; layout-grid-mode: line"><font style="font-size: 10pt">Innocoll Holdings plc Constitution, adopted on March 16, 2016 (incorporated by reference to Exhibit 3.1 to our Report on Form 6-K filed on March 16, 2016).</font></td></tr>
<tr style="vertical-align: top">
    <TD STYLE="padding-right: 0; padding-left: 0; text-align: center; layout-grid-mode: line">&nbsp;</td>
    <TD STYLE="padding-right: 0; padding-left: 0; text-indent: 0in; layout-grid-mode: line">&nbsp;</td>
    <TD STYLE="padding-right: 0; padding-left: 0; layout-grid-mode: line; text-indent: -11.25pt">&nbsp;</td></tr>
<tr style="vertical-align: top">
    <TD STYLE="padding-right: 0; padding-left: 0; text-align: center; layout-grid-mode: line">&nbsp;&nbsp;<font style="font-size: 10pt">5.1</font></td>
    <TD STYLE="padding-right: 0; padding-left: 0; text-indent: 0in; layout-grid-mode: line">&nbsp;</td>
    <TD STYLE="padding-right: 0; padding-left: 0; layout-grid-mode: line; text-indent: 0"><font style="font-size: 10pt">Opinion of William Fry.</font></td></tr>
<tr style="vertical-align: top">
    <TD STYLE="padding-right: 0; padding-left: 0; text-align: center; layout-grid-mode: line">&nbsp;</td>
    <TD STYLE="padding-right: 0; padding-left: 0; text-indent: 0in; layout-grid-mode: line">&nbsp;</td>
    <TD STYLE="padding-right: 0; padding-left: 0; layout-grid-mode: line; text-indent: -11.25pt">&nbsp;</td></tr>
<tr style="vertical-align: top">
    <TD STYLE="padding-right: 0; padding-left: 0; text-align: center; layout-grid-mode: line"><font style="font-size: 10pt">10.1</font></td>
    <TD STYLE="padding-right: 0; padding-left: 0; text-indent: 0in; layout-grid-mode: line">&nbsp;</td>
    <TD STYLE="padding-right: 0; padding-left: 0; layout-grid-mode: line; text-indent: 0"><font style="font-size: 10pt">2016 Omnibus Incentive Compensation Plan</font></td></tr>
</table>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>


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    <DIV STYLE="page-break-before: always; margin-top: 6pt; margin-bottom: 12pt"><P STYLE="margin: 0pt">&nbsp;</P></DIV>
    <!-- Field: /Page -->

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
<tr style="vertical-align: bottom">
    <TD STYLE="width: 10%; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; border-bottom: Black 1pt solid; layout-grid-mode: line"><FONT STYLE="font-size: 8pt"><B>Exhibit
    </B><br>
    <B>Number</B></FONT></td>
    <TD STYLE="width: 2%; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in; layout-grid-mode: line; padding-bottom: 1pt"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></td>
    <TD STYLE="width: 88%; padding-left: 11.25pt; text-align: center; text-indent: -11.25pt; layout-grid-mode: line; border-bottom: Black 1pt solid"><FONT STYLE="font-size: 8pt"><B>Description
    of Exhibit</B></FONT></td></tr>
<tr style="vertical-align: top">
    <TD STYLE="padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; layout-grid-mode: line"><font style="font-size: 10pt">10.2</font></td>
    <TD STYLE="padding-right: 5.4pt; padding-left: 5.4pt; text-indent: 0in; layout-grid-mode: line">&nbsp;</td>
    <TD STYLE="padding-right: 5.4pt; padding-left: 11.25pt; layout-grid-mode: line; text-indent: -11.25pt"><font style="font-size: 10pt">Amended and Restated 2015 Stock Option Plan</font></td></tr>
<tr style="vertical-align: top">
    <TD STYLE="padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; layout-grid-mode: line">&nbsp;</td>
    <TD STYLE="padding-right: 5.4pt; padding-left: 5.4pt; text-indent: 0in; layout-grid-mode: line">&nbsp;</td>
    <TD STYLE="padding-right: 5.4pt; padding-left: 11.25pt; layout-grid-mode: line; text-indent: -11.25pt">&nbsp;</td></tr>
<tr style="vertical-align: top">
    <TD STYLE="padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; layout-grid-mode: line"><font style="font-size: 10pt">10.3</font></td>
    <TD STYLE="padding-right: 5.4pt; padding-left: 5.4pt; text-indent: 0in; layout-grid-mode: line">&nbsp;</td>
    <TD STYLE="padding-right: 5.4pt; padding-left: 11.25pt; layout-grid-mode: line; text-indent: -11.25pt"><font style="font-size: 10pt">Form of Amended and Restated Form of Stock Option Agreement for Certain Stock Option Grants</font></td></tr>
<tr style="vertical-align: top">
    <TD STYLE="padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; layout-grid-mode: line">&nbsp;</td>
    <TD STYLE="padding-right: 5.4pt; padding-left: 5.4pt; text-indent: 0in; layout-grid-mode: line">&nbsp;</td>
    <TD STYLE="padding-right: 5.4pt; padding-left: 11.25pt; layout-grid-mode: line; text-indent: -11.25pt">&nbsp;</td></tr>
<tr style="vertical-align: top">
    <TD STYLE="padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; layout-grid-mode: line"><font style="font-size: 10pt">23.1</font></td>
    <TD STYLE="padding-right: 5.4pt; padding-left: 5.4pt; text-indent: 0in; layout-grid-mode: line">&nbsp;</td>
    <TD STYLE="padding-right: 5.4pt; padding-left: 11.25pt; layout-grid-mode: line; text-indent: -11.25pt"><font style="font-size: 10pt">Consent of William Fry (included in Exhibit 5.1).</font></td></tr>
<tr style="vertical-align: top">
    <TD STYLE="padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; layout-grid-mode: line">&nbsp;</td>
    <TD STYLE="padding-right: 5.4pt; padding-left: 5.4pt; text-indent: 0in; layout-grid-mode: line">&nbsp;</td>
    <TD STYLE="padding-right: 5.4pt; padding-left: 11.25pt; layout-grid-mode: line; text-indent: -11.25pt">&nbsp;</td></tr>
<tr style="vertical-align: top">
    <TD STYLE="padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; layout-grid-mode: line"><font style="font-size: 10pt">23.2</font></td>
    <TD STYLE="padding-right: 5.4pt; padding-left: 5.4pt; text-indent: 0in; layout-grid-mode: line">&nbsp;</td>
    <TD STYLE="padding-right: 5.4pt; padding-left: 11.25pt; layout-grid-mode: line; text-indent: -11.25pt"><font style="font-size: 10pt">Consent of Grant Thornton, independent registered public accounting firm.</font></td></tr>
<tr style="vertical-align: top">
    <TD STYLE="padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; layout-grid-mode: line">&nbsp;</td>
    <TD STYLE="padding-right: 5.4pt; padding-left: 5.4pt; text-indent: 0in; layout-grid-mode: line">&nbsp;</td>
    <TD STYLE="padding-right: 5.4pt; padding-left: 11.25pt; layout-grid-mode: line; text-indent: -11.25pt">&nbsp;</td></tr>
<tr style="vertical-align: top">
    <TD STYLE="padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; layout-grid-mode: line"><font style="font-size: 10pt">24.1</font></td>
    <TD STYLE="padding-right: 5.4pt; padding-left: 5.4pt; text-indent: 0in; layout-grid-mode: line">&nbsp;</td>
    <TD STYLE="padding-right: 5.4pt; padding-left: 11.25pt; layout-grid-mode: line; text-indent: -11.25pt"><font style="font-size: 10pt">Power of Attorney (included on the signature page of this Registration Statement).</font></td></tr>
</table>
<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 27pt; text-indent: 0in">&nbsp;</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 27pt; text-indent: 0in">Item 9.<FONT STYLE="font-family: Times New Roman, Times, Serif">
&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</FONT>UNDERTAKINGS.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 63pt; text-align: justify; text-indent: -0.5in">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 27pt"></TD><TD STYLE="width: 36pt">(a)</TD><TD STYLE="text-align: justify">We hereby undertake:</TD></TR></TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 84.6pt; text-align: justify; text-indent: -0.3in">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 63pt"></TD><TD STYLE="width: 21.6pt">(1)</TD><TD STYLE="text-align: justify">To file, during any period in which offers or sales are being made of the securities registered
hereby, a post-effective amendment to this Registration Statement:</TD></TR></TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 93.5pt; text-align: justify; text-indent: -21.5pt">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 72pt"></TD><TD STYLE="width: 21.5pt">(i)</TD><TD STYLE="text-align: justify">to include any prospectus required by Section 10(a)(3) of the Securities Act of 1933 (the &ldquo;Securities
Act&rdquo;);</TD></TR></TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 93.5pt; text-align: justify; text-indent: -21.5pt">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 72pt"></TD><TD STYLE="width: 21.5pt">(ii)</TD><TD STYLE="text-align: justify">to reflect in the prospectus any facts or events arising after the effective date of this Registration
Statement (or the most recent post-effective amendment thereof) which, individually or in the aggregate, represent a fundamental
change in the information set forth in this Registration Statement. Notwithstanding the foregoing, any increase or decrease in
the volume of securities offered (if the total dollar value of securities offered would not exceed that which was registered) and
any deviation from the low or high end of the estimated maximum offering range may be reflected in the form of prospectus filed
with the SEC pursuant to Rule 424(b) if, in the aggregate, the changes in volume and price represent no more than a 20% change
in the maximum aggregate offering price set forth in the &ldquo;Calculation of Registration Fee&rdquo; table in the effective Registration
Statement; and</TD></TR></TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 93.5pt; text-align: justify; text-indent: -21.5pt">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 72pt"></TD><TD STYLE="width: 21.5pt">(iii)</TD><TD STYLE="text-align: justify">to include any material information with respect to the plan of distribution not previously disclosed
in this Registration Statement or any material change to such information in this Registration Statement;</TD></TR></TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in; text-align: justify">provided, however, that the undertakings
set forth in paragraphs (i) and (ii) above do not apply if the information required to be included in a post-effective amendment
by those paragraphs is contained in periodic reports filed with or furnished to the SEC by us pursuant to Section&nbsp;13 or Section
15(d) of the Exchange Act that are incorporated by reference in this Registration Statement.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 84.6pt; text-align: justify; text-indent: -0.3in">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 63pt"></TD><TD STYLE="width: 21.6pt">(2)</TD><TD STYLE="text-align: justify">That, for the purpose of determining any liability under the Securities Act, each such post-effective
amendment shall be deemed to be a new registration statement relating to the securities offered therein, and the offering of such
securities at that time shall be deemed to be the initial <I>bona fide</I> offering thereof.</TD></TR></TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 84.6pt; text-align: justify; text-indent: -0.3in">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 63pt"></TD><TD STYLE="width: 21.6pt">(3)</TD><TD STYLE="text-align: justify">To remove from registration by means of a post-effective amendment any of the securities being
registered hereby which remain unsold at the termination of the offering.</TD></TR></TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 63pt; text-align: justify; text-indent: -0.5in">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 27pt"></TD><TD STYLE="width: 36pt">(b)</TD><TD STYLE="text-align: justify">We hereby undertake that, for purposes of determining any liability under the Securities Act, each
filing of our annual report pursuant to Section&nbsp;13(a) or Section&nbsp;15(d) of the Exchange Act (and, where applicable, each
filing of an employee benefit plan&rsquo;s annual report pursuant to Section&nbsp;15(d) of the Exchange Act) that is incorporated
by reference in this Registration Statement shall be</TD></TR></TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 63pt; text-align: justify; text-indent: -0.5in">&nbsp;</P>


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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 63.35pt; text-align: justify; text-indent: 0in">deemed to
be a new registration statement relating to the securities offered herein, and the offering of such securities at that time shall
be deemed to be the initial <I>bona fide</I> offering thereof.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 27pt"></TD><TD STYLE="width: 36pt">(h)</TD><TD STYLE="text-align: justify">Insofar as indemnification for liabilities arising under the Securities Act may be permitted to
our directors, officers and controlling persons pursuant to the foregoing provisions, or otherwise, we have been advised that in
the opinion of the Commission such indemnification is against public policy as expressed in the Securities Act and is, therefore,
unenforceable. In the event that a claim for indemnification against such liabilities (other than the payment by us of expenses
incurred or paid by a director, officer or controlling person of ours in the successful defense of any action, suit or proceeding)
is asserted by such director, officer or controlling person in connection with the securities being registered, we will, unless
in the opinion of our counsel the matter has been settled by controlling precedent, submit to a court of appropriate jurisdiction
the question whether such indemnification by us is against public policy as expressed in the Securities Act and will be governed
by the final adjudication of such issue.</TD></TR></TABLE>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-transform: uppercase; text-align: center">&nbsp;</P>


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<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-transform: uppercase; text-align: center">&nbsp;</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-transform: uppercase; text-align: center"><U>SIGNATURES</U></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0in">Pursuant to the requirements
of the Securities Act of 1933, the registrant certifies that it has reasonable grounds to believe that it meets all of the requirements
for filing on Form S-8 and has duly caused this registration statement to be signed on its behalf by the undersigned, thereunto
duly authorized, in the City of Newtown Square, State of Pennsylvania on June 3, 2016.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 3.5in"><B>&nbsp;</B></P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
<tr style="vertical-align: top">
    <TD STYLE="layout-grid-mode: line">&nbsp;</td>
    <td colspan="2" style="layout-grid-mode: line"><font style="font-size: 10pt"><b>INNOCOLL HOLDINGS PLC</b></font></td>
    <TD STYLE="layout-grid-mode: line">&nbsp;</td></tr>
<tr style="vertical-align: top">
    <TD STYLE="width: 50%; layout-grid-mode: line">&nbsp;</td>
    <TD STYLE="width: 5%; layout-grid-mode: line">&nbsp;</td>
    <TD STYLE="width: 25%; layout-grid-mode: line">&nbsp;</td>
    <TD STYLE="width: 20%; layout-grid-mode: line">&nbsp;</td></tr>
<tr style="vertical-align: top">
    <TD STYLE="layout-grid-mode: line">&nbsp;</td>
    <TD STYLE="layout-grid-mode: line"><font style="font-size: 10pt">By:</font></td>
    <TD STYLE="border-bottom: Black 1pt solid; layout-grid-mode: line"><FONT STYLE="font-size: 10pt">&nbsp;/s/ Anthony P. Zook</FONT></td>
    <TD STYLE="layout-grid-mode: line"><font style="font-size: 10pt">&nbsp;</font></td></tr>
<tr style="vertical-align: top">
    <TD STYLE="layout-grid-mode: line">&nbsp;</td>
    <TD STYLE="layout-grid-mode: line">&nbsp;</td>
    <TD STYLE="padding-left: 9pt; layout-grid-mode: line"><font style="font-size: 10pt">Anthony P. Zook</font></td>
    <TD STYLE="layout-grid-mode: line">&nbsp;</td></tr>
<tr style="vertical-align: top">
    <TD STYLE="layout-grid-mode: line">&nbsp;</td>
    <TD STYLE="layout-grid-mode: line">&nbsp;</td>
    <TD STYLE="padding-left: 9pt; layout-grid-mode: line"><font style="font-size: 10pt">Chief Executive Officer</font></td>
    <TD STYLE="layout-grid-mode: line">&nbsp;</td></tr>
</table>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 3.5in">&nbsp;</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-transform: uppercase; text-align: center"><U>POWER
OF ATTORNEY</U></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0in">KNOW ALL PERSONS BY THESE
PRESENTS, that each person whose signature appears below constitutes and appoints, jointly and severally, Anthony P. Zook and Jose
Carmona, and each one of them, as his or her true and lawful attorneys-in-fact and agents, each with full power of substitution
and resubstitution, for him or her and in his or her name, place and stead, in any and all capacities, to sign any and all amendments
(including post-effective amendments) to this Registration Statement on Form S-8, and to file the same, with all exhibits thereto
and all documents in connection therewith, with the Securities and Exchange Commission, and granting unto each of said attorneys-in-fact
and agents, and substitute or substitutes, full power and authority to do and perform each and every act and thing requisite and
necessary to be done in and about the premises, as fully to all intents and purposes as he or she might or could do in person,
and hereby ratifying and confirming all things that each of said attorneys-in-fact and agents or any of them, or his, her or their
substitute or substitutes, may lawfully do or cause to be done by virtue hereof. This Power of Attorney may be executed in counterparts,
each of which shall be deemed an original, but which taken together shall constitute an instrument.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0in">Pursuant to the requirements
of the Securities Act of 1933, this Registration Statement has been signed by the following persons in the capacities and on the
dates indicated.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<table cellspacing="0" cellpadding="0" style="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
<tr style="vertical-align: top">
    <td style="width: 34%; border-bottom: Black 1pt solid; layout-grid-mode: line; text-align: center"><FONT STYLE="font-size: 8pt"><B>Signature</B></FONT></td>
    <td style="width: 2%; layout-grid-mode: line; text-align: center"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></td>
    <td style="width: 41%; border-bottom: Black 1pt solid; layout-grid-mode: line; text-align: center"><FONT STYLE="font-size: 8pt"><B>Title</B></FONT></td>
    <td style="width: 5%; layout-grid-mode: line; text-align: center"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></td>
    <td style="width: 18%; border-bottom: Black 1pt solid; layout-grid-mode: line; text-align: center"><FONT STYLE="font-size: 8pt"><B>Date</B></FONT></td></tr>
<tr>
    <td style="vertical-align: bottom; layout-grid-mode: line">&nbsp;</td>
    <td style="vertical-align: top; layout-grid-mode: line">&nbsp;</td>
    <td style="vertical-align: bottom; layout-grid-mode: line; text-align: center">&nbsp;</td>
    <td style="vertical-align: top; layout-grid-mode: line">&nbsp;</td>
    <td style="vertical-align: bottom; layout-grid-mode: line; text-align: center">&nbsp;</td></tr>
<tr>
    <td style="vertical-align: bottom; border-bottom: Black 1pt solid; layout-grid-mode: line">/s/ Anthony P. Zook</td>
    <td style="vertical-align: top; layout-grid-mode: line">&nbsp;</td>
    <td style="vertical-align: bottom; layout-grid-mode: line; text-align: center"><font style="font-size: 10pt">Chief Executive Officer and Director</font></td>
    <td style="vertical-align: top; layout-grid-mode: line">&nbsp;</td>
    <td style="vertical-align: bottom; layout-grid-mode: line; text-align: center"><FONT STYLE="font-size: 10pt">June 3,
    2016</FONT></td></tr>
<tr>
    <td style="vertical-align: bottom; layout-grid-mode: line"><font style="font-size: 10pt">Anthony P. Zook</font></td>
    <td style="vertical-align: top; layout-grid-mode: line">&nbsp;</td>
    <td style="vertical-align: bottom; layout-grid-mode: line; text-align: center"><font style="font-size: 10pt">&nbsp;(Principal executive officer)</font></td>
    <td style="vertical-align: top; layout-grid-mode: line">&nbsp;</td>
    <td style="vertical-align: bottom; layout-grid-mode: line; text-align: center">&nbsp;</td></tr>
<tr>
    <td style="vertical-align: bottom; layout-grid-mode: line">&nbsp;</td>
    <td style="vertical-align: top; layout-grid-mode: line">&nbsp;</td>
    <td style="vertical-align: bottom; layout-grid-mode: line; text-align: center">&nbsp;</td>
    <td style="vertical-align: top; layout-grid-mode: line">&nbsp;</td>
    <td style="vertical-align: bottom; layout-grid-mode: line; text-align: center">&nbsp;</td></tr>
<tr>
    <td style="vertical-align: bottom; border-bottom: Black 1pt solid; layout-grid-mode: line">/s/ Jose Carmona</td>
    <td style="vertical-align: top; layout-grid-mode: line">&nbsp;</td>
    <td style="vertical-align: bottom; layout-grid-mode: line; text-align: center"><font style="font-size: 10pt">Chief Financial Officer</font></td>
    <td style="vertical-align: top; layout-grid-mode: line">&nbsp;</td>
    <td style="vertical-align: bottom; layout-grid-mode: line; text-align: center"><font style="font-size: 10pt">June 3, 2016</font></td></tr>
<tr>
    <td style="vertical-align: bottom; layout-grid-mode: line"><font style="font-size: 10pt">Jose Carmona</font></td>
    <td style="vertical-align: top; layout-grid-mode: line">&nbsp;</td>
    <td style="vertical-align: bottom; layout-grid-mode: line; text-align: center"><font style="font-size: 10pt">&nbsp;(Principal Financial Officer)</font></td>
    <td style="vertical-align: top; layout-grid-mode: line">&nbsp;</td>
    <td style="vertical-align: bottom; layout-grid-mode: line; text-align: center">&nbsp;</td></tr>
<tr>
    <td style="vertical-align: bottom; layout-grid-mode: line">&nbsp;</td>
    <td style="vertical-align: top; layout-grid-mode: line">&nbsp;</td>
    <td style="vertical-align: bottom; layout-grid-mode: line; text-align: center">&nbsp;</td>
    <td style="vertical-align: top; layout-grid-mode: line">&nbsp;</td>
    <td style="vertical-align: bottom; layout-grid-mode: line; text-align: center">&nbsp;</td></tr>
<tr>
    <td style="vertical-align: bottom; border-bottom: Black 1pt solid; layout-grid-mode: line">/s/ Jonathan Symonds, CBE</td>
    <td style="vertical-align: top; layout-grid-mode: line">&nbsp;</td>
    <td style="vertical-align: bottom; layout-grid-mode: line; text-align: center"><font style="font-size: 10pt">Chairman</font></td>
    <td style="vertical-align: top; layout-grid-mode: line">&nbsp;</td>
    <td style="vertical-align: bottom; layout-grid-mode: line; text-align: center"><font style="font-size: 10pt">June 3, 2016</font></td></tr>
<tr>
    <td style="vertical-align: bottom; layout-grid-mode: line"><font style="font-size: 10pt">Jonathan Symonds, CBE</font></td>
    <td style="vertical-align: top; layout-grid-mode: line">&nbsp;</td>
    <td style="vertical-align: bottom; layout-grid-mode: line; text-align: center">&nbsp;</td>
    <td style="vertical-align: top; layout-grid-mode: line">&nbsp;</td>
    <td style="vertical-align: bottom; layout-grid-mode: line; text-align: center">&nbsp;</td></tr>
<tr>
    <td style="vertical-align: bottom; layout-grid-mode: line">&nbsp;</td>
    <td style="vertical-align: top; layout-grid-mode: line">&nbsp;</td>
    <td style="vertical-align: bottom; layout-grid-mode: line; text-align: center">&nbsp;</td>
    <td style="vertical-align: top; layout-grid-mode: line">&nbsp;</td>
    <td style="vertical-align: bottom; layout-grid-mode: line; text-align: center">&nbsp;</td></tr>
<tr>
    <td style="vertical-align: bottom; border-bottom: Black 1pt solid; layout-grid-mode: line">/s/ Shumeet Banerji, Ph.D.</td>
    <td style="vertical-align: top; layout-grid-mode: line">&nbsp;</td>
    <td style="vertical-align: bottom; layout-grid-mode: line; text-align: center"><font style="font-size: 10pt">Vice Chairman</font></td>
    <td style="vertical-align: top; layout-grid-mode: line">&nbsp;</td>
    <td style="vertical-align: bottom; layout-grid-mode: line; text-align: center"><font style="font-size: 10pt">June 3, 2016</font></td></tr>
<tr>
    <td style="vertical-align: bottom; layout-grid-mode: line"><font style="font-size: 10pt">Shumeet Banerji, Ph.D.</font></td>
    <td style="vertical-align: top; layout-grid-mode: line">&nbsp;</td>
    <td style="vertical-align: bottom; layout-grid-mode: line; text-align: center">&nbsp;</td>
    <td style="vertical-align: top; layout-grid-mode: line">&nbsp;</td>
    <td style="vertical-align: bottom; layout-grid-mode: line; text-align: center">&nbsp;</td></tr>
<tr>
    <td style="vertical-align: bottom; layout-grid-mode: line">&nbsp;</td>
    <td style="vertical-align: top; layout-grid-mode: line">&nbsp;</td>
    <td style="vertical-align: bottom; layout-grid-mode: line; text-align: center">&nbsp;</td>
    <td style="vertical-align: top; layout-grid-mode: line">&nbsp;</td>
    <td style="vertical-align: bottom; layout-grid-mode: line; text-align: center">&nbsp;</td></tr>
<tr>
    <td style="vertical-align: bottom; border-bottom: Black 1pt solid; layout-grid-mode: line">/s/ A. James Culverwell</td>
    <td style="vertical-align: top; layout-grid-mode: line">&nbsp;</td>
    <td style="vertical-align: bottom; layout-grid-mode: line; text-align: center"><font style="font-size: 10pt">Director</font></td>
    <td style="vertical-align: top; layout-grid-mode: line">&nbsp;</td>
    <td style="vertical-align: bottom; layout-grid-mode: line; text-align: center"><font style="font-size: 10pt">June 3, 2016</font></td></tr>
<tr>
    <td style="vertical-align: bottom; layout-grid-mode: line"><font style="font-size: 10pt">A. James Culverwell</font></td>
    <td style="vertical-align: top; layout-grid-mode: line">&nbsp;</td>
    <td style="vertical-align: bottom; layout-grid-mode: line; text-align: center">&nbsp;</td>
    <td style="vertical-align: top; layout-grid-mode: line">&nbsp;</td>
    <td style="vertical-align: bottom; layout-grid-mode: line; text-align: center">&nbsp;</td></tr>
<tr>
    <td style="vertical-align: bottom; layout-grid-mode: line">&nbsp;</td>
    <td style="vertical-align: top; layout-grid-mode: line">&nbsp;</td>
    <td style="vertical-align: bottom; layout-grid-mode: line; text-align: center">&nbsp;</td>
    <td style="vertical-align: top; layout-grid-mode: line">&nbsp;</td>
    <td style="vertical-align: bottom; layout-grid-mode: line; text-align: center">&nbsp;</td></tr>
<tr>
    <td style="vertical-align: bottom; border-bottom: Black 1pt solid; layout-grid-mode: line">/s/ David R. Brennan</td>
    <td style="vertical-align: top; layout-grid-mode: line">&nbsp;</td>
    <td style="vertical-align: bottom; layout-grid-mode: line; text-align: center"><font style="font-size: 10pt">Director</font></td>
    <td style="vertical-align: top; layout-grid-mode: line">&nbsp;</td>
    <td style="vertical-align: bottom; layout-grid-mode: line; text-align: center"><font style="font-size: 10pt">June 3, 2016</font></td></tr>
<tr>
    <td style="vertical-align: bottom; layout-grid-mode: line"><font style="font-size: 10pt">David R. Brennan</font></td>
    <td style="vertical-align: top; layout-grid-mode: line">&nbsp;</td>
    <td style="vertical-align: bottom; layout-grid-mode: line; text-align: center">&nbsp;</td>
    <td style="vertical-align: top; layout-grid-mode: line">&nbsp;</td>
    <td style="vertical-align: bottom; layout-grid-mode: line; text-align: center">&nbsp;</td></tr>
<tr>
    <td style="vertical-align: bottom; layout-grid-mode: line">&nbsp;</td>
    <td style="vertical-align: top; layout-grid-mode: line">&nbsp;</td>
    <td style="vertical-align: bottom; layout-grid-mode: line; text-align: center">&nbsp;</td>
    <td style="vertical-align: top; layout-grid-mode: line">&nbsp;</td>
    <td style="vertical-align: bottom; layout-grid-mode: line; text-align: center">&nbsp;</td></tr>
<tr>
    <td style="vertical-align: bottom; border-bottom: Black 1pt solid; layout-grid-mode: line">/s/ Rolf D. Schmidt</td>
    <td style="vertical-align: top; layout-grid-mode: line">&nbsp;</td>
    <td style="vertical-align: bottom; layout-grid-mode: line; text-align: center"><font style="font-size: 10pt">Director</font></td>
    <td style="vertical-align: top; layout-grid-mode: line">&nbsp;</td>
    <td style="vertical-align: bottom; layout-grid-mode: line; text-align: center"><font style="font-size: 10pt">June 3, 2016</font></td></tr>
<tr>
    <td style="vertical-align: bottom; layout-grid-mode: line"><font style="font-size: 10pt">Rolf D. Schmidt</font></td>
    <td style="vertical-align: top; layout-grid-mode: line">&nbsp;</td>
    <td style="vertical-align: bottom; layout-grid-mode: line; text-align: center">&nbsp;</td>
    <td style="vertical-align: top; layout-grid-mode: line">&nbsp;</td>
    <td style="vertical-align: bottom; layout-grid-mode: line; text-align: center">&nbsp;</td></tr>
<tr>
    <td style="vertical-align: bottom; layout-grid-mode: line">&nbsp;</td>
    <td style="vertical-align: top; layout-grid-mode: line">&nbsp;</td>
    <td style="vertical-align: bottom; layout-grid-mode: line; text-align: center">&nbsp;</td>
    <td style="vertical-align: top; layout-grid-mode: line">&nbsp;</td>
    <td style="vertical-align: bottom; layout-grid-mode: line; text-align: center">&nbsp;</td></tr>
<tr>
    <td style="vertical-align: bottom; border-bottom: Black 1pt solid; layout-grid-mode: line">/s/ Joseph Wiley M.D.</td>
    <td style="vertical-align: top; layout-grid-mode: line">&nbsp;</td>
    <td style="vertical-align: bottom; layout-grid-mode: line; text-align: center"><font style="font-size: 10pt">Director</font></td>
    <td style="vertical-align: top; layout-grid-mode: line">&nbsp;</td>
    <td style="vertical-align: bottom; layout-grid-mode: line; text-align: center"><font style="font-size: 10pt">June 3, 2016</font></td></tr>
<tr>
    <td style="vertical-align: bottom; layout-grid-mode: line"><font style="font-size: 10pt">Joseph Wiley M.D.</font></td>
    <td style="vertical-align: top; layout-grid-mode: line">&nbsp;</td>
    <td style="vertical-align: bottom; layout-grid-mode: line; text-align: center">&nbsp;</td>
    <td style="vertical-align: top; layout-grid-mode: line">&nbsp;</td>
    <td style="vertical-align: bottom; layout-grid-mode: line; text-align: center">&nbsp;</td></tr>
</table>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><FONT STYLE="text-transform: uppercase"><B>&nbsp;</B></FONT></P>


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<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-transform: uppercase; text-align: center"><U>INDEX
TO EXHIBITS</U></P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-transform: uppercase; text-align: center">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
<tr style="vertical-align: bottom">
    <TD STYLE="width: 10%; border-bottom: Black 1pt solid; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; layout-grid-mode: line"><FONT STYLE="font-size: 8pt"><B>Exhibit
    </B><br>
    <B>Number</B></FONT></td>
    <TD STYLE="width: 2%; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; text-indent: 0in; layout-grid-mode: line"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></td>
    <TD STYLE="width: 88%; border-bottom: Black 1pt solid; padding-left: 11.25pt; text-align: center; text-indent: -11.25pt; layout-grid-mode: line"><FONT STYLE="font-size: 8pt"><B>Description
    of Exhibit</B></FONT></td></tr>
<tr style="vertical-align: top">
    <TD STYLE="padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; layout-grid-mode: line">&nbsp;</td>
    <TD STYLE="padding-right: 5.4pt; padding-left: 5.4pt; text-indent: 0in; layout-grid-mode: line">&nbsp;</td>
    <TD STYLE="padding-right: 5.4pt; padding-left: 5.4pt; layout-grid-mode: line">&nbsp;</td></tr>
<tr style="vertical-align: top">
    <TD STYLE="padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; layout-grid-mode: line"><font style="font-size: 10pt">&nbsp;&nbsp;3.1</font></td>
    <TD STYLE="padding-right: 5.4pt; padding-left: 5.4pt; text-indent: 0in; layout-grid-mode: line">&nbsp;</td>
    <TD STYLE="padding-right: 5.4pt; padding-left: 0; layout-grid-mode: line"><font style="font-size: 10pt">Innocoll Holdings plc Constitution, adopted on March 16, 2016 (incorporated by reference to Exhibit 3.1 to our Report on Form 6-K filed on March 16, 2016).</font></td></tr>
<tr style="vertical-align: top">
    <TD STYLE="padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; layout-grid-mode: line">&nbsp;</td>
    <TD STYLE="padding-right: 5.4pt; padding-left: 5.4pt; text-indent: 0in; layout-grid-mode: line">&nbsp;</td>
    <TD STYLE="padding-right: 5.4pt; padding-left: 11.25pt; layout-grid-mode: line; text-indent: -11.25pt">&nbsp;</td></tr>
<tr style="vertical-align: top">
    <TD STYLE="padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; layout-grid-mode: line"><font style="font-size: 10pt">&nbsp;&nbsp;5.1</font></td>
    <TD STYLE="padding-right: 5.4pt; padding-left: 5.4pt; text-indent: 0in; layout-grid-mode: line">&nbsp;</td>
    <TD STYLE="padding-right: 5.4pt; padding-left: 11.25pt; layout-grid-mode: line; text-indent: -11.25pt"><font style="font-size: 10pt">Opinion of William Fry.</font></td></tr>
<tr style="vertical-align: top">
    <TD STYLE="padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; layout-grid-mode: line">&nbsp;</td>
    <TD STYLE="padding-right: 5.4pt; padding-left: 5.4pt; text-indent: 0in; layout-grid-mode: line">&nbsp;</td>
    <TD STYLE="padding-right: 5.4pt; padding-left: 11.25pt; layout-grid-mode: line; text-indent: -11.25pt">&nbsp;</td></tr>
<tr style="vertical-align: top">
    <TD STYLE="padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; layout-grid-mode: line"><font style="font-size: 10pt">10.1</font></td>
    <TD STYLE="padding-right: 5.4pt; padding-left: 5.4pt; text-indent: 0in; layout-grid-mode: line">&nbsp;</td>
    <TD STYLE="padding-right: 5.4pt; padding-left: 11.25pt; layout-grid-mode: line; text-indent: -11.25pt"><font style="font-size: 10pt">2016 Omnibus Incentive Compensation Plan</font></td></tr>
<tr style="vertical-align: top">
    <TD STYLE="padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; layout-grid-mode: line">&nbsp;</td>
    <TD STYLE="padding-right: 5.4pt; padding-left: 5.4pt; text-indent: 0in; layout-grid-mode: line">&nbsp;</td>
    <TD STYLE="padding-right: 5.4pt; padding-left: 11.25pt; layout-grid-mode: line; text-indent: -11.25pt">&nbsp;</td></tr>
<tr style="vertical-align: top">
    <TD STYLE="padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; layout-grid-mode: line"><font style="font-size: 10pt">10.2</font></td>
    <TD STYLE="padding-right: 5.4pt; padding-left: 5.4pt; text-indent: 0in; layout-grid-mode: line">&nbsp;</td>
    <TD STYLE="padding-right: 5.4pt; padding-left: 11.25pt; layout-grid-mode: line; text-indent: -11.25pt"><font style="font-size: 10pt">Amended and Restated 2015 Stock Option Plan</font></td></tr>
<tr style="vertical-align: top">
    <TD STYLE="padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; layout-grid-mode: line">&nbsp;</td>
    <TD STYLE="padding-right: 5.4pt; padding-left: 5.4pt; text-indent: 0in; layout-grid-mode: line">&nbsp;</td>
    <TD STYLE="padding-right: 5.4pt; padding-left: 11.25pt; layout-grid-mode: line; text-indent: -11.25pt">&nbsp;</td></tr>
<tr style="vertical-align: top">
    <TD STYLE="padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; layout-grid-mode: line"><font style="font-size: 10pt">10.3</font></td>
    <TD STYLE="padding-right: 5.4pt; padding-left: 5.4pt; text-indent: 0in; layout-grid-mode: line">&nbsp;</td>
    <TD STYLE="padding-right: 5.4pt; padding-left: 11.25pt; layout-grid-mode: line; text-indent: -11.25pt"><font style="font-size: 10pt">Form of Amended and Restated Form of Stock Option Agreement for Certain Stock Option Grants</font></td></tr>
<tr style="vertical-align: top">
    <TD STYLE="padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; layout-grid-mode: line">&nbsp;</td>
    <TD STYLE="padding-right: 5.4pt; padding-left: 5.4pt; text-indent: 0in; layout-grid-mode: line">&nbsp;</td>
    <TD STYLE="padding-right: 5.4pt; padding-left: 11.25pt; layout-grid-mode: line; text-indent: -11.25pt">&nbsp;</td></tr>
<tr style="vertical-align: top">
    <TD STYLE="padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; layout-grid-mode: line"><font style="font-size: 10pt">23.1</font></td>
    <TD STYLE="padding-right: 5.4pt; padding-left: 5.4pt; text-indent: 0in; layout-grid-mode: line">&nbsp;</td>
    <TD STYLE="padding-right: 5.4pt; padding-left: 11.25pt; layout-grid-mode: line; text-indent: -11.25pt"><font style="font-size: 10pt">Consent of William Fry (included in Exhibit 5.1).</font></td></tr>
<tr style="vertical-align: top">
    <TD STYLE="padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; layout-grid-mode: line">&nbsp;</td>
    <TD STYLE="padding-right: 5.4pt; padding-left: 5.4pt; text-indent: 0in; layout-grid-mode: line">&nbsp;</td>
    <TD STYLE="padding-right: 5.4pt; padding-left: 11.25pt; layout-grid-mode: line; text-indent: -11.25pt">&nbsp;</td></tr>
<tr style="vertical-align: top">
    <TD STYLE="padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; layout-grid-mode: line"><font style="font-size: 10pt">23.2</font></td>
    <TD STYLE="padding-right: 5.4pt; padding-left: 5.4pt; text-indent: 0in; layout-grid-mode: line">&nbsp;</td>
    <TD STYLE="padding-right: 5.4pt; padding-left: 11.25pt; layout-grid-mode: line; text-indent: -11.25pt"><font style="font-size: 10pt">Consent of Grant Thornton, independent registered public accounting firm.</font></td></tr>
<tr style="vertical-align: top">
    <TD STYLE="padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; layout-grid-mode: line">&nbsp;</td>
    <TD STYLE="padding-right: 5.4pt; padding-left: 5.4pt; text-indent: 0in; layout-grid-mode: line">&nbsp;</td>
    <TD STYLE="padding-right: 5.4pt; padding-left: 11.25pt; layout-grid-mode: line; text-indent: -11.25pt">&nbsp;</td></tr>
<tr style="vertical-align: top">
    <TD STYLE="padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; layout-grid-mode: line"><font style="font-size: 10pt">24.1</font></td>
    <TD STYLE="padding-right: 5.4pt; padding-left: 5.4pt; text-indent: 0in; layout-grid-mode: line">&nbsp;</td>
    <TD STYLE="padding-right: 5.4pt; padding-left: 11.25pt; layout-grid-mode: line; text-indent: -11.25pt"><font style="font-size: 10pt">Power of Attorney (included on the signature page of this Registration Statement).</font></td></tr>
</table>
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[{"type": "S-8", "sequence": "1", "filename": "t1601455_s8.htm", "description": "FORM S-8", "secsgml_size_bytes": 84757}]
{"company-data": {"conformed-name": "Innocoll Holdings plc", "cik": "0001660484", "assigned-sic": "2834", "irs-number": "000000000", "state-of-incorporation": "L2", "fiscal-year-end": "1231"}, "filing-values": {"form-type": "S-8", "act": "33", "file-number": "333-211801", "film-number": "161694542"}, "business-address": {"street1": "UNIT 9, BLOCK D, MONKSLAND BUSINESS PARK", "street2": "MONKSLAND", "city": "ATHLONE", "state": "L2", "zip": "NONE", "phone": "353(0) 90 6486834"}, "mail-address": {"street1": "UNIT 9, BLOCK D, MONKSLAND BUSINESS PARK", "street2": "MONKSLAND", "city": "ATHLONE", "state": "L2", "zip": "NONE"}}
As filed with the Securities and Exchange
Commission on June 3, 2016
Registration No. 333-
UNITED STATES
SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
_________________
FORM S-8
REGISTRATION STATEMENT
UNDER
THE SECURITIES ACT OF 1933
_________________
INNOCOLL
HOLDINGS PUBLIC LIMITED COMPANY
(Exact Name of Registrant as Specified
in its Charter)
_________________
Ireland
(State of Incorporation)
Not Applicable
(I.R.S. Employer Identification No.)
Innocoll Holdings plc
Unit 9, Block D
Monksland Business Park
Monksland, Athlone, Co. Roscommon
Ireland
(Address of Principal Executive Offices)
2016 Omnibus Incentive Compensation Plan
Amended and Restated 2015 Stock Option
Plan
Certain Amended and Restated Option Agreements
(Full Title of the Plans)
Anthony P. Zook
3803 West Chester Pike
Suite 190
Newtown Square, PA 19073
(610) 405-2347
(Name, Address and Telephone Number of
Agent for Service)
_________________
Copies to:
Jeffrey A. Baumel, Esq.
Ilan Katz, Esq.
Dentons US LLP
1221 Avenue of the Americas
New York, New York 10020
(212) 768-6700
_________________
Indicate by check mark whether the Registrant is a large accelerated
filer, an accelerated filer, a non-accelerated filer, or smaller reporting company. See the definitions of "large accelerated
filer," "accelerated filer" and "smaller reporting company" in Rule 12b-2 of the Exchange Act.:
¨
Large accelerated filer
þ
Accelerated filer
¨
Non-accelerated filer
¨
Smaller reporting company
________________
CALCULATION OF REGISTRATION FEE
Title of Securities
to be Registered
(1)
Amount to
be
Registered
(2)
Proposed
Maximum
Offering
Price Per
Share
(3)
Proposed
Maximum
Aggregate
Offering Price
(3)
Amount of
Registration
Fee
2016 Omnibus Incentive Compensation Plan
1,480,993
(4)
$
10.50
(8)
$
15,550,426.50
$
1,565.93
2016 Omnibus Incentive Compensation Plan
1,369,007
(5)
$
8.50
(9)
$
11,636,559.50
$
1,171.80
Amended and Restated 2015 Stock Option Plan
1,194,407
(6)
$
10.92
(10)
$
13,042,924.44
$
1,313.42
Certain Amended and Restated Option Agreements
328,388
(7)
$
9.00
(11)
$
2,955,492.00
$
297.62
Total
4,372,795
N/A
$
43,185,402.44
$
4,348.77
(1)
Ordinary shares, $0.01 par value per share ("Ordinary Shares"), of Innocoll Holdings
plc ("Innocoll").
(2)
Pursuant to Rule 416(a), this Registration Statement also covers any additional securities that
may be offered or issued in connection with any stock split, stock dividend or similar transaction.
(3)
Estimated in accordance with Rule 457(h) solely for the purpose of calculating the registration
fee.
(4)
Represents Ordinary Shares that may be issued pursuant to the Innocoll 2016 Omnibus Incentive Compensation
Plan.
(5)
Represents Ordinary Shares issuable pursuant to outstanding but unexercised options previously
granted under the 2016 Omnibus Incentive Compensation Plan.
(6)
Represents Ordinary Shares issuable pursuant to outstanding but unexercised options previously
granted under the Amended and Restated 2015 Stock Option Plan.
(7)
Represents Ordinary Shares issuable pursuant to outstanding but unexercised options previously
granted to certain former or current employees of Innocoll.
(8)
With respect to the 1,480,993 Ordinary Shares that are authorized under the 2016 Omnibus Incentive
Compensation Plan (excluding shares issuable under outstanding options), estimated solely for the purpose of calculating the registration
fee in accordance with Rule 457(h), based upon the average of the high and low prices of the Ordinary Shares reported on the NASDAQ
Global Market on May 26, 2016 of $10.50.
(9)
With respect to the 1,369,007 Ordinary Shares that are issuable upon exercise of currently outstanding
awards under the 2016 Omnibus Incentive Compensation Plan, estimated in accordance with Rule 457(h) solely for the purpose of calculating
the registration fee on the basis of the weighted average option exercise price of $8.50 per share.
(10)
With respect to the 1,194,407 Ordinary Shares that are issuable upon exercise of currently outstanding
awards under the Amended and Restated 2015 Stock Option Plan, estimated in accordance with Rule 457(h) solely for the purpose of
calculating the registration fee on the basis of the weighted average option exercise price of $10.92 per share.
(11)
With respect to the 328,388 Ordinary Shares that are issuable upon exercise of currently outstanding
awards issued to certain former or current employees of Innocoll, estimated in accordance with Rule 457(h) solely for the purpose
of calculating the registration fee on the basis of the weighted average option exercise price of $9.00 per share.
EXPLANATORY NOTE
Innocoll Holdings plc
("we" or the "Registrant") has prepared this Registration Statement in accordance with the requirements
of Form S-8 under the Securities Act of 1933, as amended (the "Securities Act"). This Registration Statement registers
4,372,795 of our ordinary shares, par value $0.01 per share ("Ordinary Shares") which may be issued from time to time
to: (i) recipients of future awards under our 2016 Omnibus Incentive Compensation Plan; (ii) holders of outstanding awards issued
under our 2016 Omnibus Incentive Compensation Plan; (iii) holders of outstanding awards issued under our Amended and Restated 2015
Stock Option Plan; and (iv) Gordon Dunn, Paul Oxholm, Michael Myers, Dennis Langer, Denise Carter, David Prior, Alex Dietrich,
James Croke, Turlough O' Connor, Pauline Ogle and Aaron Wyse upon the exercise of options granted to such individuals pursuant
to certain Amended and Restated Option Agreements.
PART I
INFORMATION REQUIRED IN THE SECTION 10(a)
PROSPECTUS
The documents containing
the information specified in Part I of Form S-8 will be sent or given to participants in the plans or arrangements as specified
by Rule 428(b)(1) under the Securities Act. In accordance with Rule 428 and the requirements of Part I of Form S-8, such documents
are not required to be and are not filed with the Securities and Exchange Commission (the "Commission") either as part
of this Registration Statement or as prospectuses or prospectus supplements pursuant to Rule 424 under the Securities Act. These
documents and the documents incorporated by reference in this Registration Statement pursuant to Item 3 of Part II of this Form
S-8, taken together, constitute a prospectus that meets the requirements of Section 10(a) of the Securities Act.
PART II
INFORMATION REQUIRED IN THE REGISTRATION
STATEMENT
Item 3.       INCORPORATION
OF DOCUMENTS BY REFERENCE.
The following documents,
which we have filed with the Securities and Exchange Commission (the "Commission") are hereby incorporated
by reference into this Registration Statement:
·
Our Annual Report on Form 20-F for the year ended December 31, 2015 filed with the Commission on
March 17, 2016;
·
Our
                                         Current Reports on Form 6-K filed with the Commission on March 3, 2016, April
                                         27, 2016, May 25, 2016 (excluding Exhibit 99.2 thereto) and May 31, 2016; and
·
The description of our ordinary shares contained in our Current Report on Form 6-K using the EDGAR
format type 8-K12B filed with the Commission on March 16, 2016, which incorporates such description of our ordinary shares by reference
to our Registration Statement Form F-4 (File No. 333-208438), as filed with the Commission on December 10, 2015 and amended on
December 22, 2015 as and declared effective by the Commission on December 22, 2015.
All documents filed
by us pursuant to Sections 13(a), 13(c), 14 and 15(d) of the Securities Exchange Act of 1934 (the "Exchange Act")
on or after the date of this Registration Statement and prior to the filing of a post-effective amendment to this Registration
Statement which indicates that all securities registered hereby have been sold or which deregisters such securities then remaining
unsold shall be deemed to be incorporated by reference in this Registration Statement and to be a part hereof from the date of
filing of such documents, except for information furnished to the SEC that is not deemed to be "filed" for purposes
of the Exchange Act (such documents, and the documents listed above, being hereinafter referred to as "Incorporated Documents").
Any statement contained herein or in an Incorporated Document shall be deemed to be modified or superseded for purposes of this
Registration Statement to the extent that a statement contained herein or in any other subsequently filed Incorporated
2
Document modifies or
supersedes such statement. Any such statement so modified or superseded shall not be deemed, except as so modified or superseded,
to constitute a part of this Registration Statement.
Item 4.        DESCRIPTION
OF SECURITIES.
Not Applicable. Our Ordinary Shares are
registered pursuant to Section 12(b) of the Exchange Act, and, therefore, the description thereof is omitted.
Item 5.        INTERESTS
OF NAMED EXPERTS AND COUNSEL.
None.
Item 6.        INDEMNIFICATION
OF BOARD MEMBERS AND OFFICERS.
To the fullest extent
permitted by Irish law, the constitution of the Registrant confers an indemnity on the Registrant's directors and officers
(each an "Indemnified Person") who was or is a party or is threatened to be made a party to any action, suit or proceeding
by reason of the fact that he or she is or was an Indemnified Person against expenses (including legal fees), judgments, fines
and amounts paid in settlement, actually and reasonably incurred by such Indemnified Person in connection with such action, suit
or proceeding (subject to them meeting an applicable standard of conduct). However, this indemnity is limited by the Irish Companies
Act 2014 (the "Companies Act"), which prescribes that an advance commitment to indemnify only permits a company to
pay the costs or discharge the liability of a director or secretary where judgment is given in favor of the director or secretary
in any civil or criminal action in respect of such costs or liability, where he is acquitted or where an Irish court grants relief
because the director or secretary acted honestly and reasonably and ought fairly to be excused. Any provision whereby an Irish
company seeks to commit in advance to indemnify its directors or secretary over and above the limitations imposed by the Companies
Act will be void under Irish law, whether contained in its articles of association or any contract between the company and the
director or secretary. This restriction does not apply to our executives who are not directors or company secretary and our constitution
also contains indemnification provisions for persons who are not directors or our company secretary.
We are permitted under
our articles of association and the Companies Act to take out directors' and officers' liability insurance, as well
as other types of insurance, for our directors, officers, employees and agents.
One or more of the
Registrant's subsidiaries has or will enter into indemnification agreements with each of the Registrant's directors,
secretary and executive officers (as may be determined by the board of directors of the Registrant from time to time), providing
for the indemnification of, and advancement of expenses to, such persons, to the fullest extent permitted by law.
Item 7.        EXEMPTION FROM
REGISTRATION CLAIMED.
Not Applicable.
Item 8.        EXHIBITS.
Exhibit
Number
Description
    of Exhibit
3.1
Innocoll Holdings plc Constitution, adopted on March 16, 2016 (incorporated by reference to Exhibit 3.1 to our Report on Form 6-K filed on March 16, 2016).
5.1
Opinion of William Fry.
10.1
2016 Omnibus Incentive Compensation Plan
3
Exhibit
Number
Description
    of Exhibit
10.2
Amended and Restated 2015 Stock Option Plan
10.3
Form of Amended and Restated Form of Stock Option Agreement for Certain Stock Option Grants
23.1
Consent of William Fry (included in Exhibit 5.1).
23.2
Consent of Grant Thornton, independent registered public accounting firm.
24.1
Power of Attorney (included on the signature page of this Registration Statement).
Item 9.
UNDERTAKINGS.
(a)
We hereby undertake:
(1)
To file, during any period in which offers or sales are being made of the securities registered
hereby, a post-effective amendment to this Registration Statement:
(i)
to include any prospectus required by Section 10(a)(3) of the Securities Act of 1933 (the "Securities
Act");
(ii)
to reflect in the prospectus any facts or events arising after the effective date of this Registration
Statement (or the most recent post-effective amendment thereof) which, individually or in the aggregate, represent a fundamental
change in the information set forth in this Registration Statement. Notwithstanding the foregoing, any increase or decrease in
the volume of securities offered (if the total dollar value of securities offered would not exceed that which was registered) and
any deviation from the low or high end of the estimated maximum offering range may be reflected in the form of prospectus filed
with the SEC pursuant to Rule 424(b) if, in the aggregate, the changes in volume and price represent no more than a 20% change
in the maximum aggregate offering price set forth in the "Calculation of Registration Fee" table in the effective Registration
Statement; and
(iii)
to include any material information with respect to the plan of distribution not previously disclosed
in this Registration Statement or any material change to such information in this Registration Statement;
provided, however, that the undertakings
set forth in paragraphs (i) and (ii) above do not apply if the information required to be included in a post-effective amendment
by those paragraphs is contained in periodic reports filed with or furnished to the SEC by us pursuant to Section 13 or Section
15(d) of the Exchange Act that are incorporated by reference in this Registration Statement.
(2)
That, for the purpose of determining any liability under the Securities Act, each such post-effective
amendment shall be deemed to be a new registration statement relating to the securities offered therein, and the offering of such
securities at that time shall be deemed to be the initial
bona fide
offering thereof.
(3)
To remove from registration by means of a post-effective amendment any of the securities being
registered hereby which remain unsold at the termination of the offering.
(b)
We hereby undertake that, for purposes of determining any liability under the Securities Act, each
filing of our annual report pursuant to Section 13(a) or Section 15(d) of the Exchange Act (and, where applicable, each
filing of an employee benefit plan's annual report pursuant to Section 15(d) of the Exchange Act) that is incorporated
by reference in this Registration Statement shall be
4
deemed to
be a new registration statement relating to the securities offered herein, and the offering of such securities at that time shall
be deemed to be the initial
bona fide
offering thereof.
(h)
Insofar as indemnification for liabilities arising under the Securities Act may be permitted to
our directors, officers and controlling persons pursuant to the foregoing provisions, or otherwise, we have been advised that in
the opinion of the Commission such indemnification is against public policy as expressed in the Securities Act and is, therefore,
unenforceable. In the event that a claim for indemnification against such liabilities (other than the payment by us of expenses
incurred or paid by a director, officer or controlling person of ours in the successful defense of any action, suit or proceeding)
is asserted by such director, officer or controlling person in connection with the securities being registered, we will, unless
in the opinion of our counsel the matter has been settled by controlling precedent, submit to a court of appropriate jurisdiction
the question whether such indemnification by us is against public policy as expressed in the Securities Act and will be governed
by the final adjudication of such issue.
5
SIGNATURES
Pursuant to the requirements
of the Securities Act of 1933, the registrant certifies that it has reasonable grounds to believe that it meets all of the requirements
for filing on Form S-8 and has duly caused this registration statement to be signed on its behalf by the undersigned, thereunto
duly authorized, in the City of Newtown Square, State of Pennsylvania on June 3, 2016.
INNOCOLL HOLDINGS PLC
By:
/s/ Anthony P. Zook
Anthony P. Zook
Chief Executive Officer
POWER
OF ATTORNEY
KNOW ALL PERSONS BY THESE
PRESENTS, that each person whose signature appears below constitutes and appoints, jointly and severally, Anthony P. Zook and Jose
Carmona, and each one of them, as his or her true and lawful attorneys-in-fact and agents, each with full power of substitution
and resubstitution, for him or her and in his or her name, place and stead, in any and all capacities, to sign any and all amendments
(including post-effective amendments) to this Registration Statement on Form S-8, and to file the same, with all exhibits thereto
and all documents in connection therewith, with the Securities and Exchange Commission, and granting unto each of said attorneys-in-fact
and agents, and substitute or substitutes, full power and authority to do and perform each and every act and thing requisite and
necessary to be done in and about the premises, as fully to all intents and purposes as he or she might or could do in person,
and hereby ratifying and confirming all things that each of said attorneys-in-fact and agents or any of them, or his, her or their
substitute or substitutes, may lawfully do or cause to be done by virtue hereof. This Power of Attorney may be executed in counterparts,
each of which shall be deemed an original, but which taken together shall constitute an instrument.
Pursuant to the requirements
of the Securities Act of 1933, this Registration Statement has been signed by the following persons in the capacities and on the
dates indicated.
Signature
Title
Date
/s/ Anthony P. Zook
Chief Executive Officer and Director
June 3,
    2016
Anthony P. Zook
(Principal executive officer)
/s/ Jose Carmona
Chief Financial Officer
June 3, 2016
Jose Carmona
(Principal Financial Officer)
/s/ Jonathan Symonds, CBE
Chairman
June 3, 2016
Jonathan Symonds, CBE
/s/ Shumeet Banerji, Ph.D.
Vice Chairman
June 3, 2016
Shumeet Banerji, Ph.D.
/s/ A. James Culverwell
Director
June 3, 2016
A. James Culverwell
/s/ David R. Brennan
Director
June 3, 2016
David R. Brennan
/s/ Rolf D. Schmidt
Director
June 3, 2016
Rolf D. Schmidt
/s/ Joseph Wiley M.D.
Director
June 3, 2016
Joseph Wiley M.D.
6
INDEX
TO EXHIBITS
Exhibit
Number
Description
    of Exhibit
3.1
Innocoll Holdings plc Constitution, adopted on March 16, 2016 (incorporated by reference to Exhibit 3.1 to our Report on Form 6-K filed on March 16, 2016).
5.1
Opinion of William Fry.
10.1
2016 Omnibus Incentive Compensation Plan
10.2
Amended and Restated 2015 Stock Option Plan
10.3
Form of Amended and Restated Form of Stock Option Agreement for Certain Stock Option Grants
23.1
Consent of William Fry (included in Exhibit 5.1).
23.2
Consent of Grant Thornton, independent registered public accounting firm.
24.1
Power of Attorney (included on the signature page of this Registration Statement).
7