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<P STYLE="margin: 0">&nbsp;&nbsp;</P>

<P STYLE="font: 8pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; background-color: transparent"><B>As filed
with the Securities and Exchange Commission on August&nbsp;3, 2017</B></P>

<P STYLE="font: bold 8pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: right; background-color: transparent">Registration
No. 333-&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</P>

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<P STYLE="font: bold 8pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: right; background-color: transparent"></P>

<P STYLE="font: bold 16pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; background-color: transparent">UNITED
STATES</P>

<P STYLE="font: bold 16pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; background-color: transparent">SECURITIES
AND EXCHANGE COMMISSION</P>

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<P STYLE="font: bold 16pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; background-color: transparent"></P>

<P STYLE="font: bold 9pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; background-color: transparent">Washington,
D.C. 20549</P>

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<P STYLE="font: bold 9pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; background-color: transparent"></P>

<P STYLE="font: bold 15pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; background-color: transparent">FORM
S-8</P>

<P STYLE="font: bold 13pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; background-color: transparent">REGISTRATION
STATEMENT</P>

<P STYLE="font: bold 9pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; background-color: transparent"><I>UNDER</I></P>

<P STYLE="font: bold 9pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; background-color: transparent"><I>THE
SECURITIES ACT OF 1933</I></P>

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<P STYLE="font: bold 9pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; background-color: transparent"><I></I></P>

<P STYLE="font: bold 24pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; background-color: transparent">FLUIDIGM
CORPORATION</P>

<P STYLE="font: bold 7.5pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; background-color: transparent">(Exact
name of Registrant as specified in its charter)</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in; background-color: white">&nbsp;</P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in; background-color: white"></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in; background-color: white">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="width: 100%; border-collapse: collapse; font-family: Times New Roman, Times, Serif">
<tr style="vertical-align: top; background-color: white">
    <TD STYLE="width: 33%; text-align: center; font-size: 11pt; font-weight: bold">Delaware</td>
    <TD STYLE="width: 34%; text-align: center; font-size: 11pt; font-weight: bold">&nbsp;</td>
    <TD STYLE="width: 33%; text-align: center; font-size: 11pt; font-weight: bold">77-0513190</td></tr>
<tr style="vertical-align: top; background-color: white">
    <TD STYLE="text-align: center; font-size: 8pt; font-weight: bold"><font style="font-size: 7pt">(State or other jurisdiction of</font><br>
<font style="font-size: 7pt">incorporation or organization)</font></td>
    <TD STYLE="text-align: center; font-size: 8pt; font-weight: bold">&nbsp;</td>
    <TD STYLE="text-align: center; font-size: 8pt; font-weight: bold"><font style="font-size: 7pt">(I.R.S. Employer</font><br>
<font style="font-size: 7pt">Identification No.)</font></td></tr>
</table>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in; background-color: white">&nbsp;</P>

<P STYLE="font: 11pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; text-indent: 0in; background-color: transparent"><B>7000
Shoreline Court, Suite 100</B></P>

<P STYLE="font: 11pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; text-indent: 0in; background-color: transparent"><B>South
San Francisco, California 94080</B></P>

<P STYLE="font: 11pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; text-indent: 0in; background-color: transparent"><B>(650)
266-6000</B></P>

<P STYLE="font: bold 7pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; background-color: transparent">(Address
of principal executive offices, including zip code)</P>

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<P STYLE="font: bold 7pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; background-color: transparent"></P>

<P STYLE="font: bold 12pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; background-color: transparent">Fluidigm
Corporation 2017 Employee Stock Purchase Plan</P>

<P STYLE="font: bold 7pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; background-color: transparent">(Full
title of the plan)</P>

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<P STYLE="font: bold 7pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; background-color: transparent"></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; text-indent: 0in; background-color: transparent"><B>Stephen
Christopher Linthwaite</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; text-indent: 0in; background-color: transparent"><B>President
and Chief Executive Officer</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; text-indent: 0in; background-color: transparent"><B>7000
Shoreline Court, Suite 100</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; text-indent: 0in; background-color: transparent"><B>South
San Francisco, California 94080</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; text-indent: 0in; background-color: transparent"><B>(650)
266-6000</B></P>

<P STYLE="font: 7pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; background-color: transparent"><B>(Name,
address and telephone number, including area code, of agent for service)</B></P>

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<P STYLE="font: 7pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; background-color: transparent"><B></B></P>

<P STYLE="font: 9pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; background-color: transparent"><I>Copies
to:</I></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; text-indent: 0in; background-color: transparent"><B>Nicholas
Khadder</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; text-indent: 0in; background-color: transparent"><B>General
Counsel</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; text-indent: 0in; background-color: transparent"><B>7000
Shoreline Court, Suite 100</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; text-indent: 0in; background-color: transparent"><B>South
San Francisco, California 94080</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; text-indent: 0in; background-color: transparent"><B>Telephone:
(650) 266-6000</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; text-indent: 0in; background-color: transparent"><B>&nbsp;</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; text-indent: 0in; background-color: transparent"><B>Robert
F. Kornegay</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; text-indent: 0in; background-color: transparent"><B>Wilson
Sonsini Goodrich &amp; Rosati,</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; text-indent: 0in; background-color: transparent"><B>Professional
Corporation</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; text-indent: 0in; background-color: transparent"><B>650
Page Mill Road</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; text-indent: 0in; background-color: transparent"><B>Palo
Alto, California 94304</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; text-indent: 0in; background-color: transparent"><B>Telephone:
(650) 493-9300</B></P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; text-indent: 0in; background-color: transparent"><B></B></P>

<P STYLE="font: 8pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0in; background-color: transparent"><FONT STYLE="font-size: 10pt">Indicate
by check mark whether the registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, a smaller reporting
company, or an emerging growth company. See the definitions of &ldquo;large accelerated filer,&rdquo; &ldquo;accelerated filer,&rdquo;
&ldquo;smaller reporting company,&rdquo; and &ldquo;emerging growth company&rdquo; in Rule 12b-2 of the Exchange Act.</FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in; background-color: white"><FONT STYLE="font-size: 10pt">&nbsp;</FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in; background-color: white"></P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 11pt Times New Roman, Times, Serif; width: 95%; border-collapse: collapse; margin-left: 0.25in">
<TR STYLE="vertical-align: top; background-color: white">
    <TD STYLE="width: 20%; text-indent: 0in"><FONT STYLE="font-size: 10pt">Large accelerated filer</FONT></TD>
    <TD STYLE="width: 45%; text-indent: 0in"><FONT STYLE="font-family: Wingdings; font-size: 10pt">&uml;</FONT></TD>
    <TD STYLE="width: 25%; text-indent: 0in"><FONT STYLE="font-size: 10pt">Accelerated filer</FONT></TD>
    <TD STYLE="width: 10%; text-indent: 0in"><FONT STYLE="font-family: Wingdings; font-size: 10pt">x</FONT></TD></TR>
<TR STYLE="vertical-align: top; background-color: white">
    <TD STYLE="text-indent: 0in"><FONT STYLE="font-size: 10pt">Non-accelerated filer</FONT></TD>
    <TD STYLE="text-indent: 0in"><FONT STYLE="font-family: Wingdings; font-size: 10pt">&uml;</FONT><FONT STYLE="font-size: 10pt">
    (Do     not check if a smaller reporting company)</FONT></TD>
    <TD STYLE="text-indent: 0in"><FONT STYLE="font-size: 10pt">Smaller reporting company</FONT></TD>
    <TD STYLE="text-indent: 0in"><FONT STYLE="font-family: Wingdings; font-size: 10pt">&uml;</FONT></TD></TR>
<TR STYLE="vertical-align: top; background-color: white">
    <TD STYLE="text-indent: 0in"><FONT STYLE="font-size: 10pt">&nbsp;</FONT></TD>
    <TD STYLE="text-indent: 0in"><FONT STYLE="font-size: 10pt">&nbsp;</FONT></TD>
    <TD STYLE="text-indent: 0in"><FONT STYLE="font-size: 10pt">Emerging growth company</FONT></TD>
    <TD STYLE="text-indent: 0in"><FONT STYLE="font-family: Wingdings; font-size: 10pt">&uml;</FONT></TD></TR>
</TABLE>


<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in; background-color: white"><FONT STYLE="font-size: 10pt">&nbsp;</FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; background-color: transparent"></P>

<P STYLE="font: 8pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0in; background-color: white"><FONT STYLE="font-size: 10pt; background-color: white">If
an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for
complying with any new or revised financial accounting standards provided pursuant to Section 7(a)(2)(B) of the Securities Act.
<FONT STYLE="font-family: Times New Roman, Times, Serif">&#9744;</FONT></FONT></P>



<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; background-color: transparent"><FONT STYLE="font-size: 10pt"><B>&nbsp;</B></FONT></P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; background-color: transparent">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; background-color: transparent"><FONT STYLE="font-size: 10pt"><B></B></FONT></P>

<P STYLE="font: 8pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; background-color: transparent"><FONT STYLE="font-size: 10pt"><B>CALCULATION
OF REGISTRATION FEE</B></FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in; background-color: white"><FONT STYLE="font-size: 10pt">&nbsp;</FONT></P>

<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="border-collapse: collapse; width: 100%; font: 10pt Times New Roman, Times, Serif">
<TR STYLE="vertical-align: bottom">
    <TD NOWRAP STYLE="font-size: 8pt; font-weight: bold; text-align: center; border-bottom: Black 1pt solid">Title of Securities to be Registered</TD><TD NOWRAP STYLE="font-size: 8pt; font-weight: bold; padding-bottom: 1pt">&nbsp;</TD>
    <TD COLSPAN="2" NOWRAP STYLE="font-size: 8pt; font-weight: bold; text-align: center; border-bottom: Black 1pt solid"><FONT STYLE="font-size: 8pt">Amount<br> to be Registered<SUP>(1)</SUP></FONT></TD><TD NOWRAP STYLE="padding-bottom: 1pt; font-size: 8pt; font-weight: bold">&nbsp;</TD><TD NOWRAP STYLE="font-size: 8pt; font-weight: bold; padding-bottom: 1pt">&nbsp;</TD>
    <TD COLSPAN="2" NOWRAP STYLE="font-size: 8pt; font-weight: bold; text-align: center; border-bottom: Black 1pt solid">Proposed<BR> Maximum Offering<BR> Price Per Share</TD><TD NOWRAP STYLE="padding-bottom: 1pt; font-size: 8pt; font-weight: bold"><SUP>&nbsp;</SUP></TD><TD NOWRAP STYLE="font-size: 8pt; font-weight: bold; padding-bottom: 1pt">&nbsp;</TD>
    <TD COLSPAN="2" NOWRAP STYLE="font-size: 8pt; font-weight: bold; text-align: center; border-bottom: Black 1pt solid">Proposed<BR> Maximum Aggregate<BR> Offering Price</TD><TD NOWRAP STYLE="padding-bottom: 1pt; font-size: 8pt; font-weight: bold">&nbsp;</TD><TD NOWRAP STYLE="font-size: 8pt; font-weight: bold; padding-bottom: 1pt">&nbsp;</TD>
    <TD COLSPAN="2" NOWRAP STYLE="font-size: 8pt; font-weight: bold; text-align: center; border-bottom: Black 1pt solid">Amount of<BR> Registration Fee</TD><TD NOWRAP STYLE="padding-bottom: 1pt; font-size: 8pt; font-weight: bold">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: rgb(204,238,255)">
    <TD STYLE="width: 40%; text-align: justify; padding-bottom: 1pt; text-indent: 0in; padding-left: 0in">Common Stock, $0.001 par value per share, reserved for issuance pursuant to the Fluidigm Corporation 2017 Employee Stock Purchase Plan</TD><TD STYLE="width: 1%; padding-bottom: 1pt">&nbsp;</TD>
    <TD STYLE="width: 1%; border-bottom: Black 1pt solid; text-align: left">&nbsp;</TD><TD STYLE="width: 12%; border-bottom: Black 1pt solid; text-align: right">1,000,000</TD><TD STYLE="width: 1%; padding-bottom: 1pt; text-align: left">&nbsp;</TD><TD STYLE="width: 1%; padding-bottom: 1pt">&nbsp;</TD>
    <TD STYLE="width: 1%; border-bottom: Black 1pt solid; text-align: left">$</TD><TD STYLE="width: 12%; border-bottom: Black 1pt solid; text-align: right">3.28</TD><TD STYLE="width: 1%; padding-bottom: 1pt; text-align: left"><SUP>(2)</SUP></TD><TD STYLE="width: 1%; padding-bottom: 1pt">&nbsp;</TD>
    <TD STYLE="width: 1%; border-bottom: Black 1pt solid; text-align: left">$</TD><TD STYLE="width: 12%; border-bottom: Black 1pt solid; text-align: right">3,280,000.00</TD><TD STYLE="width: 1%; padding-bottom: 1pt; text-align: left">&nbsp;</TD><TD STYLE="width: 1%; padding-bottom: 1pt">&nbsp;</TD>
    <TD STYLE="width: 1%; border-bottom: Black 1pt solid; text-align: left">$</TD><TD STYLE="width: 12%; border-bottom: Black 1pt solid; text-align: right">380.15</TD><TD STYLE="width: 1%; padding-bottom: 1pt; text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: White">
    <TD STYLE="text-align: justify; padding-bottom: 1pt; text-indent: 0in; padding-left: 0in">TOTAL:</TD><TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
    <TD STYLE="border-bottom: Black 1pt solid; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 1pt solid; text-align: right">1,000,000</TD><TD STYLE="padding-bottom: 1pt; text-align: left">&nbsp;</TD><TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
    <TD STYLE="border-bottom: Black 1pt solid; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 1pt solid; text-align: right">&nbsp;</TD><TD STYLE="padding-bottom: 1pt; text-align: left"><SUP>&nbsp;</SUP></TD><TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
    <TD STYLE="border-bottom: Black 1pt solid; text-align: left">$</TD><TD STYLE="border-bottom: Black 1pt solid; text-align: right">3,280,000.00</TD><TD STYLE="padding-bottom: 1pt; text-align: left">&nbsp;</TD><TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
    <TD STYLE="border-bottom: Black 1pt solid; text-align: left">$</TD><TD STYLE="border-bottom: Black 1pt solid; text-align: right">380.15</TD><TD STYLE="padding-bottom: 1pt; text-align: left">&nbsp;</TD></TR>
</TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0in; background-color: transparent">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 0pt"><TR STYLE="vertical-align: top; text-align: justify">
<TD STYLE="width: 0"></TD><TD STYLE="width: 0.25in; text-align: left">(1)</TD><TD STYLE="text-align: left">Pursuant to Rule 416(a) of the Securities Act of 1933,
as amended, this Registration Statement shall also cover any additional shares of the Registrant&rsquo;s common stock that become
issuable under the Fluidigm Corporation 2017 Employee Stock Purchase Plan (the &ldquo;2017 ESPP&rdquo;) by reason of any stock
dividend, stock split, recapitalization or other similar transaction effected without receipt of consideration that increases
the number of the Registrant&rsquo;s outstanding shares of common stock.</TD>
</TR></TABLE>

<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 0pt"><TR STYLE="vertical-align: top; text-align: justify">
<TD STYLE="width: 0"></TD><TD STYLE="width: 0.25in; text-align: left">(2)</TD><TD STYLE="text-align: left">Estimated in accordance with Rule 457(h) solely for the
purpose of calculating the total registration fee. Computation based upon 85% (see explanation in following sentence) of $3.85,
the average of the high and low prices of the Registrant&rsquo;s common stock as reported on the Nasdaq Global Select Market on
July 28, 2017. Pursuant to the 2017 ESPP, the purchase price of the shares of common stock reserved for issuance thereunder will
be 85% of the lower of the fair market value of the common stock on (i) the first trading day of the offering period or (ii) the
exercise date.</TD>
</TR></TABLE>



<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; text-indent: 0in; background-color: transparent"><B>&nbsp;</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; text-indent: 0in; background-color: transparent"><B></B></P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; text-indent: 0in; background-color: transparent"><B></B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; text-indent: 0in; background-color: transparent"><B>&nbsp;</B></P>


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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; text-indent: 0in; background-color: transparent"><B>&nbsp;</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; text-indent: 0in; background-color: transparent"><B>FLUIDIGM
CORPORATION </B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; text-indent: 0in; background-color: transparent"><B>&nbsp;</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; text-indent: 0in; background-color: transparent"><B>EXPLANATORY
NOTE</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in; background-color: transparent">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in; background-color: transparent">This Registration
Statement is filed by Fluidigm Corporation (the &ldquo;Registrant&rdquo;) for the purpose of registering 1,000,000 shares of common
stock of the Registrant that are currently reserved for issuance under the Fluidigm Corporation 2017 Employee Stock Purchase Plan.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; text-indent: 0in; background-color: transparent"><B>&nbsp;</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; text-indent: 0in; background-color: transparent"><B>PART
I</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; text-indent: 0in; background-color: transparent"><B>&nbsp;</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; text-indent: 0in; background-color: transparent"><B>INFORMATION
REQUIRED IN THE PROSPECTUS</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: left; text-indent: 0.5in; background-color: transparent"><FONT STYLE="font-weight: normal">&nbsp;</FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: left; text-indent: 0.5in; background-color: transparent"><FONT STYLE="font-weight: normal">The
information specified in Item 1 and Item 2 of Part I of Form S-8 is omitted from this Registration Statement on Form S-8 (the &ldquo;Registration
Statement&rdquo;) in accordance with the provisions of Rule 428 under the Securities Act of 1933, as amended (the &ldquo;Securities
Act&rdquo;), and the introductory note to Part I of Form S-8. The documents containing the information specified in Part I of Form
S-8 will be delivered to the participants in the equity benefit plan covered by this Registration Statement as specified by Rule
428(b)(1) under the Securities Act. </FONT></P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; text-indent: 0.5in; background-color: transparent">&nbsp;</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; background-color: transparent">PART
II</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; background-color: transparent">&nbsp;</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; background-color: transparent">INFORMATION
REQUIRED IN REGISTRATION STATEMENT</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; background-color: transparent">&nbsp;</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; background-color: transparent">Item
3.&nbsp;&nbsp;Incorporation of Documents by Reference.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.5in; background-color: transparent">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24.5pt; background-color: transparent">The
Registrant hereby incorporates by reference into this Registration Statement the following documents previously filed with the
Commission:</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 63.5pt; text-indent: -39pt; background-color: transparent">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; background-color: transparent"><TR STYLE="vertical-align: top">
<TD STYLE="width: 24.5pt"></TD><TD STYLE="width: 39pt">(1)</TD><TD>The Registrant&rsquo;s Annual Report on Form 10-K for the fiscal year ended December 31, 2016, filed with the Commission on
March 3, 2017 and the Registrant&rsquo;s Amendment No. 1 to the Registrant&rsquo;s Form 10-K, filed with the Commission on April
28, 2017;</TD></TR></TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 63.5pt; text-indent: -39pt; background-color: transparent"></P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; background-color: transparent"><TR STYLE="vertical-align: top">
<TD STYLE="width: 24.5pt"></TD><TD STYLE="width: 39pt">(2)</TD><TD>The Registrant&rsquo;s Quarterly Report on Form 10-Q for the three months ended March 31, 2017, filed with the Commission on
May 9, 2017;</TD></TR></TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 63.5pt; text-indent: -39pt; background-color: transparent"></P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; background-color: transparent"><TR STYLE="vertical-align: top">
<TD STYLE="width: 24.5pt"></TD><TD STYLE="width: 39pt">(3)</TD><TD>The Registrant&rsquo;s Current Reports on Form 8-K filed with
                                         the Commission on January 11, 2017, February 10, 2017, March 2, 2017, March 27, 2017,
                                         May 24, 2017, August&nbsp;2, 2017, August 2, 2017, August 3, 2017, and
                                         August 3, 2017 only to the extent that the items therein are specifically stated
                                         to be &ldquo;filed&rdquo; rather than &ldquo;furnished&rdquo; for the purposes of Section
                                         18 of the Securities Exchange Act of 1934, as amended (the &ldquo;Exchange Act&rdquo;);
                                         and</TD></TR></TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 63.5pt; text-indent: -39pt; background-color: transparent"></P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; background-color: transparent"><TR STYLE="vertical-align: top">
<TD STYLE="width: 24.5pt"></TD><TD STYLE="width: 39pt">(4)</TD><TD>The description of the Registrant&rsquo;s common stock contained in the Company&rsquo;s Registration Statements on Form 8-A
(File No. 001-34180) filed with the Commission on February 7, 2011, pursuant to Section 12(b) of the Exchange Act, including any
amendment or report filed for the purpose of updating such description.</TD></TR></TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 63.5pt; text-indent: -39pt; background-color: transparent">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 24.5pt; background-color: transparent">All documents
filed by the Registrant pursuant to Sections&nbsp;13(a), 13(c), 14 and 15(d) of the Exchange Act on or after the date of this Registration
Statement and prior to the filing of a post-effective amendment to this Registration Statement that indicates that all securities
offered have been sold or that deregisters all securities then remaining unsold shall be deemed to be incorporated by reference
in this Registration Statement and to be part hereof from the date of filing of such documents; <I>provided</I>, <I>however</I>,
that documents or information deemed to have been furnished and not filed in accordance with the rules of the Commission shall
not be deemed incorporated by reference into this Registration Statement. Any statement contained in a document incorporated or
deemed to be incorporated by reference herein shall be deemed to be modified or superseded for purposes of this Registration Statement
to the extent that a statement contained herein or in any subsequently filed document which also is deemed to be incorporated by
reference herein modifies or supersedes such statement. Any such statement so modified or superseded shall not be deemed, except
as so modified or superseded, to constitute a part of this Registration Statement.<FONT STYLE="font-family: Times New Roman, Times, Serif">
</FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 24.5pt; background-color: transparent">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 24.5pt; background-color: transparent">Under no
circumstances will any information furnished under current items 2.02 or 7.01 of Form 8-K be deemed incorporated herein by reference
unless such Form 8-K expressly provides to the contrary.</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; background-color: transparent">&nbsp;</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; background-color: transparent">Item
4.&nbsp;&nbsp;Description of Securities.</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; background-color: transparent">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in; text-align: justify; background-color: transparent"><FONT STYLE="font-weight: normal">Not
applicable.</FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0in; background-color: white"><B>&nbsp;</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0in; background-color: white"><B>Item 5.&nbsp;&nbsp;Interests
of Named Experts and Counsel.</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0in; background-color: white">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in; background-color: white">Not applicable.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0in; background-color: white"><B>&nbsp;</B></P>


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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0in; background-color: white"><B>&nbsp;</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0in; background-color: white"><B>Item 6.&nbsp;&nbsp;Indemnification
of Directors and Officers.</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in; background-color: white">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in; background-color: white">Section 145 of
the Delaware General Corporation Law authorizes a corporation&rsquo;s board of directors to grant, and authorizes a court to award,
indemnity to officers, directors, and other corporate agents.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in; background-color: white">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in; background-color: white">As permitted by
Section 102(b)(7) of the Delaware General Corporation Law, the Registrant&rsquo;s certificate of incorporation includes provisions
that eliminate the personal liability of its directors and officers for monetary damages for breach of their fiduciary duty as
directors and officers.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in; background-color: white">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in; background-color: white">In addition, as
permitted by Section 145 of the Delaware General Corporation Law, the bylaws of the Registrant provide that:</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 1in; text-indent: -0.25in; background-color: white">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; background-color: white"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.75in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD>The Registrant shall indemnify its directors and officers for serving the Registrant in those capacities or for serving other
business enterprises at the Registrant&rsquo;s request, to the fullest extent permitted by Delaware law. Delaware law provides
that a corporation may indemnify such person if such person acted in good faith and in a manner such person reasonably believed
to be in or not opposed to the best interests of the Registrant and, with respect to any criminal proceeding, had no reasonable
cause to believe such person&rsquo;s conduct was unlawful.</TD></TR></TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 1in; text-indent: -0.25in; background-color: white">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; background-color: white"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.75in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD>The Registrant may, in its discretion, indemnify employees and agents in those circumstances where indemnification is not required
by law.</TD></TR></TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 1in; text-indent: -0.25in; background-color: white">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; background-color: white"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.75in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD>The Registrant is required to advance expenses, as incurred, to its directors and officers in connection with defending a proceeding,
except that such director or officer shall undertake to repay such advances if it is ultimately determined that such person is
not entitled to indemnification.</TD></TR></TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 1in; text-indent: -0.25in; background-color: white">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; background-color: white"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.75in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD>The Registrant will not be obligated pursuant to the bylaws to indemnify a person with respect to proceedings initiated by
that person, except with respect to proceedings authorized by the Registrant&rsquo;s board of directors or brought to enforce a
right to indemnification.</TD></TR></TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 1in; text-indent: -0.25in; background-color: white">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; background-color: white"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.75in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD>The rights conferred in the bylaws are not exclusive, and the Registrant is authorized to enter into indemnification agreements
with its directors, officers, employees, and agents and to obtain insurance to indemnify such persons.</TD></TR></TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 1in; text-indent: -0.25in; background-color: white">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; background-color: white"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.75in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD>The Registrant may not retroactively amend the bylaw provisions to reduce its indemnification obligations to directors, officers,
employees, and agents.</TD></TR></TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in; background-color: white">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in; background-color: white">The Registrant&rsquo;s
policy is to enter into separate indemnification agreements with each of its directors and officers that provide the maximum indemnity
allowed to directors and executive officers by Section 145 of the Delaware General Corporation Law and also provides for certain
additional procedural protections. The Registrant also maintains directors and officers insurance to insure such persons against
certain liabilities.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in; background-color: white">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in; background-color: white">These indemnification
provisions and the indemnification agreements entered into between the Registrant and its officers and directors may be sufficiently
broad to permit indemnification of the Registrant&rsquo;s officers and directors for liabilities (including reimbursement of expenses
incurred) arising under the Securities Act.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in; background-color: white">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in; background-color: white">See also Registrant&rsquo;s
undertakings in Section 9 of this Registration Statement.</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; background-color: transparent">&nbsp;</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; background-color: transparent">Item
7.&nbsp;&nbsp;Exemption from Registration Claimed.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in; background-color: white">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in; background-color: white">Not applicable.</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; background-color: transparent">&nbsp;</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; background-color: transparent">Item
8.&nbsp;&nbsp;Exhibits.<BR>
<BR>
</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
<tr style="vertical-align: bottom; background-color: white">
    <TD COLSPAN="2" STYLE="border-bottom: Black 1pt solid; padding-right: 5.75pt; padding-left: 5.75pt; text-align: center"><FONT STYLE="font-size: 8pt"><B>Exhibit</B><br>
    <B>Number</B></FONT></td>
    <TD STYLE="text-align: center"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></td>
    <TD STYLE="border-bottom: Black 1pt solid; padding-right: 5.75pt; padding-left: 5.75pt; text-align: center"><FONT STYLE="font-size: 8pt"><B>Description</B></FONT></td>
    <TD STYLE="text-align: center"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></td>
    <TD STYLE="border-bottom: Black 1pt solid; text-align: center"><FONT STYLE="font-size: 8pt"><B>Incorporated</B><br>
    <B>by Reference</B><br>
    <B>From Form</B></FONT></td>
    <TD STYLE="text-align: center"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></td>
    <TD STYLE="border-bottom: Black 1pt solid; text-align: center"><FONT STYLE="font-size: 8pt"><B>Incorporated</B><br>
    <B>by Reference</B><br>
    <B>From Exhibit</B><br>
    <B>Number</B></FONT></td>
    <TD STYLE="text-align: center"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></td>
    <TD STYLE="border-bottom: Black 1pt solid; text-align: center"><FONT STYLE="font-size: 8pt"><B>Date Filed</B></FONT></td></tr>
<tr style="vertical-align: top; background-color: white">
    <TD STYLE="padding-left: 5.75pt; text-align: right; width: 5%">4.1</TD>
    <TD STYLE="padding-right: 5.75pt; padding-left: 5.75pt; text-align: right; width: 4%">&nbsp;</TD>
    <TD STYLE="width: 2%">&nbsp;</td>
    <TD STYLE="width: 45%">Specimen Common Stock Certificate of the Registrant.</td>
    <TD STYLE="width: 2%">&nbsp;</td>
    <TD STYLE="width: 14%; text-align: center">Filed herewith.</td>
    <TD STYLE="width: 2%">&nbsp;</td>
    <TD STYLE="width: 12%">&nbsp;</td>
    <TD STYLE="width: 2%">&nbsp;</td>
    <TD STYLE="width: 12%">&nbsp;</td></tr>
<tr style="vertical-align: top; background-color: white">
    <TD STYLE="padding-left: 10pt; text-align: right">4.2</TD>
    <TD STYLE="text-align: left">+</TD>
    <TD>&nbsp;</td>
    <TD>2017 Employee Stock Purchase Plan. </td>
    <TD>&nbsp;</td>
    <TD STYLE="text-align: center">8-K</td>
    <TD>&nbsp;</td>
    <TD STYLE="text-align: center">10.1</td>
    <TD>&nbsp;</td>
    <TD STYLE="text-align: center">8/2/2017</td></tr>
<tr style="vertical-align: top; background-color: white">
    <TD STYLE="padding-left: 5.75pt; text-align: right">4.5</TD>
    <TD STYLE="padding-right: 5.75pt; padding-left: 5.75pt; text-align: right">&nbsp;</TD>
    <TD>&nbsp;</td>
    <TD>Indenture, dated February 4, 2014, by and between Fluidigm Corporation and U.S. Bank National Association.</td>
    <TD>&nbsp;</td>
    <TD STYLE="text-align: center">8-K</td>
    <TD>&nbsp;</td>
    <TD STYLE="text-align: center">4.1</td>
    <TD>&nbsp;</td>
    <TD STYLE="text-align: center">2/4/2014</td></tr>
</table>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in; background-color: white">&nbsp;</P>


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    <DIV STYLE="page-break-before: always; margin-top: 6pt; margin-bottom: 12pt"><P STYLE="margin: 0pt">&nbsp;</P></DIV>
    <!-- Field: /Page -->

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in; background-color: white">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
<tr style="vertical-align: bottom; background-color: white">
    <TD COLSPAN="2" STYLE="border-bottom: Black 1pt solid; padding-right: 5.75pt; padding-left: 5.75pt; text-align: center"><FONT STYLE="font-size: 8pt"><B>Exhibit</B><br>
    <B>Number</B></FONT></td>
    <TD STYLE="text-align: center"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></td>
    <TD STYLE="border-bottom: Black 1pt solid; text-align: center"><FONT STYLE="font-size: 8pt"><B>Description</B></FONT></td>
    <TD STYLE="text-align: center"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></td>
    <TD STYLE="border-bottom: Black 1pt solid; text-align: center"><FONT STYLE="font-size: 8pt"><B>Incorporated</B><br>
    <B>by Reference</B><br>
    <B>From Form</B></FONT></td>
    <TD STYLE="text-align: center"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></td>
    <TD STYLE="border-bottom: Black 1pt solid; text-align: center"><FONT STYLE="font-size: 8pt"><B>Incorporated</B><br>
    <B>by Reference</B><br>
    <B>From Exhibit</B><br>
    <B>Number</B></FONT></td>
    <TD STYLE="text-align: center"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></td>
    <TD STYLE="border-bottom: Black 1pt solid; text-align: center"><FONT STYLE="font-size: 8pt"><B>Date Filed</B></FONT></td></tr>
<tr style="vertical-align: top; background-color: white">
    <TD STYLE="text-align: right; width: 5%">4.6</TD>
    <TD STYLE="text-align: right; width: 4%">&nbsp;</TD>
    <TD STYLE="width: 2%">&nbsp;</td>
    <TD STYLE="width: 45%">First Supplement Indenture, dated February 4, 2014, by and between Fluidigm Corporation and U.S. Bank National Association.</td>
    <TD STYLE="width: 2%">&nbsp;</td>
    <TD STYLE="width: 14%; text-align: center">8-K</td>
    <TD STYLE="width: 2%">&nbsp;</td>
    <TD STYLE="width: 12%; text-align: center">4.2</td>
    <TD STYLE="width: 2%">&nbsp;</td>
    <TD STYLE="width: 12%; text-align: center">2/4/2014</td></tr>
<tr style="vertical-align: top; background-color: white">
    <TD STYLE="text-align: right">4.7</TD>
    <TD STYLE="text-align: right">&nbsp;</TD>
    <TD>&nbsp;</td>
    <TD>Form of Global Note (included in Exhibit 4.6).</td>
    <TD>&nbsp;</td>
    <TD STYLE="text-align: center">8-K</td>
    <TD>&nbsp;</td>
    <TD STYLE="text-align: center">4.3</td>
    <TD>&nbsp;</td>
    <TD STYLE="text-align: center">2/4/2014</td></tr>
<tr style="vertical-align: top; background-color: white">
    <TD STYLE="text-align: right">5.1</TD>
    <TD STYLE="text-align: right">&nbsp;</TD>
    <TD>&nbsp;</td>
    <TD>Opinion of Wilson Sonsini Goodrich &amp; Rosati, Professional Corporation.</td>
    <TD>&nbsp;</td>
    <TD STYLE="text-align: center">Filed herewith.</td>
    <TD>&nbsp;</td>
    <TD>&nbsp;</td>
    <TD>&nbsp;</td>
    <TD>&nbsp;</td></tr>
<tr style="vertical-align: top; background-color: white">
    <TD STYLE="text-align: right">23.1</TD>
    <TD STYLE="text-align: right">&nbsp;</TD>
    <TD>&nbsp;</td>
    <TD>Consent of PricewaterhouseCoopers LLP, Independent Registered Public Accounting Firm.</td>
    <TD>&nbsp;</td>
    <TD STYLE="text-align: center">Filed herewith.</td>
    <TD>&nbsp;</td>
    <TD>&nbsp;</td>
    <TD>&nbsp;</td>
    <TD>&nbsp;</td></tr>
<tr style="vertical-align: top; background-color: white">
    <TD STYLE="text-align: right">23.2</TD>
    <TD STYLE="text-align: right">&nbsp;</TD>
    <TD>&nbsp;</td>
    <TD>Consent of Ernst &amp; Young LLP, Independent Registered Public Accounting Firm.</td>
    <TD>&nbsp;</td>
    <TD STYLE="text-align: center">Filed herewith.</td>
    <TD>&nbsp;</td>
    <TD>&nbsp;</td>
    <TD>&nbsp;</td>
    <TD>&nbsp;</td></tr>
<tr style="vertical-align: top; background-color: white">
    <TD STYLE="text-align: right">23.3</TD>
    <TD STYLE="text-align: right">&nbsp;</TD>
    <TD>&nbsp;</td>
    <TD>Consent of Wilson Sonsini Goodrich &amp; Rosati, Professional Corporation (contained in Exhibit 5.1 hereto).</td>
    <TD>&nbsp;</td>
    <TD>&nbsp;</td>
    <TD>&nbsp;</td>
    <TD>&nbsp;</td>
    <TD>&nbsp;</td>
    <TD>&nbsp;</td></tr>
<tr style="vertical-align: top; background-color: white">
    <TD STYLE="text-align: right">24.1</TD>
    <TD STYLE="text-align: right">&nbsp;</TD>
    <TD>&nbsp;</td>
    <TD>Power of Attorney (contained on signature page hereto).</td>
    <TD>&nbsp;</td>
    <TD>&nbsp;</td>
    <TD>&nbsp;</td>
    <TD>&nbsp;</td>
    <TD>&nbsp;</td>
    <TD>&nbsp;</td></tr>
</table>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; background-color: transparent"><FONT STYLE="font-weight: normal">&nbsp;</FONT></P>

<!-- Field: Rule-Page --><DIV ALIGN="LEFT"><DIV STYLE="font-size: 1pt; border-top: Black 1pt solid; width: 25%">&nbsp;</DIV></DIV><!-- Field: /Rule-Page -->

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; background-color: transparent"><FONT STYLE="font-weight: normal"></FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; background-color: transparent"><FONT STYLE="font-weight: normal">+
Indicates management contract or compensatory plan, contract or arrangement.</FONT></P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; background-color: transparent">&nbsp;</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; background-color: transparent">Item
9.&nbsp;&nbsp;Undertakings.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0in; background-color: white">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0in; background-color: white">A. The undersigned
Registrant hereby undertakes:</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in; text-indent: 0in; background-color: white">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in; text-indent: 0in; background-color: white">(1) To
file, during any period in which offers or sales are being made, a post-effective amendment to this Registration Statement:</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 1in; text-indent: 0in; background-color: white">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 1in; text-indent: 0in; background-color: white">(i) To include
any prospectus required by Section 10(a)(3) of the Securities Act of 1933;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 1in; text-indent: 0in; background-color: white">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 1in; text-indent: 0in; background-color: white">(ii) To reflect
in the prospectus any facts or events arising after the effective date of the registration statement (or the most recent post-effective
amendment thereof) which, individually or in the aggregate, represent a fundamental change in the information set forth in the
registration statement. Notwithstanding the foregoing, any increase or decrease in volume of securities offered (if the total dollar
value of securities offered would not exceed that which was registered) and any deviation from the low or high end of the estimated
maximum offering range may be reflected in the form of prospectus filed with the Commission pursuant to Rule 424(b) if, in the
aggregate, the changes in volume and price represent no more than 20% change in the maximum aggregate offering price set forth
in the &ldquo;Calculation of Registration Fee&rdquo; table in the effective registration statement;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 1in; text-indent: 0in; background-color: white">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 1in; text-indent: 0in; background-color: white">(iii) To
include any material information with respect to the plan of distribution not previously disclosed in the Registration Statement
or any material change to such information in the Registration Statement.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0in; background-color: white"><I>&nbsp;</I></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0in; background-color: white"><I>Provided, however</I>,
that: (1) Paragraphs (A)(1)(i) and (A)(1)(ii) do not apply if the information required to be included in a post-effective amendment
by those paragraphs is contained in periodic reports filed with or furnished to the Commission by the Registrant pursuant to Section
13 or Section 15(d) of the Securities Exchange Act of 1934 that are incorporated by reference in this Registration Statement.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in; text-indent: 0in; background-color: white">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in; text-indent: 0in; background-color: white">(2) That,
for the purpose of determining any liability under the Securities Act of 1933, each such post-effective amendment shall be deemed
to be a new registration statement relating to the securities offered herein, and the offering of such securities at that time
shall be deemed to be the initial bona fide offering thereof.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in; text-indent: 0in; background-color: white">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in; text-indent: 0in; background-color: white">(3) To
remove from registration by means of a post-effective amendment any of the securities being registered which remain unsold at the
termination of the offering.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0in; background-color: white">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0in; background-color: white">B. The undersigned
Registrant hereby undertakes that, for purposes of determining any liability under the Securities Act of 1933, each</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0in; background-color: white">&nbsp;</P>


<!-- Field: Page; Sequence: 4 -->
    <DIV STYLE="margin-top: 12pt; margin-bottom: 6pt; border-bottom: Black 1pt solid"><P STYLE="margin: 0pt">&nbsp;</P></DIV>
    <DIV STYLE="page-break-before: always; margin-top: 6pt; margin-bottom: 12pt"><P STYLE="margin: 0pt">&nbsp;</P></DIV>
    <!-- Field: /Page -->

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0in; background-color: white">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0in; background-color: white">filing of the Registrant&rsquo;s
annual report pursuant to Section 13(a) or Section 15(d) of the Securities Exchange Act of 1934 (and, where applicable, each filing
of an employee benefit plan&rsquo;s annual report pursuant to Section 15(d) of the Securities Exchange Act of 1934) that is incorporated
by reference in the Registration Statement shall be deemed to be a new registration statement relating to the securities offered
herein, and the offering of such securities at that time shall be deemed to be the initial bona fide offering thereof.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0in; background-color: white">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0in; background-color: white">C. Insofar as indemnification
for liabilities arising under the Securities Act of 1933 may be permitted to directors, officers and controlling persons of the
Registrant pursuant to the foregoing provisions, or otherwise, the Registrant has been advised that in the opinion of the Securities
and Exchange Commission such indemnification is against public policy as expressed in the Act and is, therefore, unenforceable.
In the event that a claim for indemnification against such liabilities (other than the payment by the Registrant of expenses incurred
or paid by a director, officer or controlling person of the Registrant in the successful defense of any action, suit or proceeding)
is asserted by such director, officer or controlling person in connection with the securities being registered, the Registrant
will, unless in the opinion of its counsel the matter has been settled by controlling precedent, submit to a court of appropriate
jurisdiction the question whether such indemnification by it is against public policy as expressed in the Act and will be governed
by the final adjudication of such issue.</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in; text-align: left; text-indent: -0.5in; background-color: transparent">&nbsp;</P>


<!-- Field: Page; Sequence: 5 -->
    <DIV STYLE="margin-top: 12pt; margin-bottom: 6pt; border-bottom: Black 1pt solid"><P STYLE="margin: 0pt">&nbsp;</P></DIV>
    <DIV STYLE="page-break-before: always; margin-top: 6pt; margin-bottom: 12pt"><P STYLE="margin: 0pt">&nbsp;</P></DIV>
    <!-- Field: /Page -->

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in; text-align: center; text-indent: -0.5in; background-color: transparent">&nbsp;</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in; text-align: center; text-indent: -0.5in; background-color: transparent">SIGNATURES</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in; background-color: transparent">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in; background-color: transparent">Pursuant
to the requirements of the Securities Act of 1933, the Registrant certifies that it has reasonable grounds to believe that it meets
all of the requirements for filing on Form S-8 and has duly caused this Registration Statement to be signed on its behalf by the
undersigned, thereunto duly authorized, in the City of South San Francisco, State of California, on August 3,
2017.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 3.5in; background-color: transparent"><B>&nbsp;</B></P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
<tr style="vertical-align: top; background-color: white">
    <TD>&nbsp;</td>
    <td colspan="2"><font style="font-size: 10pt"><b>Fluidigm Corporation</b></font></td></tr>
<tr style="vertical-align: top; background-color: white">
    <TD STYLE="width: 50%">&nbsp;</td>
    <TD STYLE="width: 4%">&nbsp;</td>
    <TD STYLE="width: 46%">&nbsp;</td></tr>
<tr style="vertical-align: top; background-color: white">
    <TD>&nbsp;</td>
    <TD><font style="font-size: 10pt">By:</font></td>
    <TD STYLE="border-bottom: Black 1pt solid"><font style="font-size: 10pt">/s/ Stephen Christopher Linthwaite</font></td></tr>
<tr style="vertical-align: top; background-color: white">
    <TD>&nbsp;</td>
    <TD>&nbsp;</td>
    <TD><font style="font-size: 10pt">Stephen Christopher Linthwaite</font></td></tr>
<tr style="vertical-align: top; background-color: white">
    <TD>&nbsp;</td>
    <TD>&nbsp;</td>
    <TD><font style="font-size: 10pt"><i>President and Chief Executive Officer </i></font></td></tr>
</table>
<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; background-color: transparent">&nbsp;</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; background-color: transparent">POWER
OF ATTORNEY</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.5in; background-color: transparent">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.5in; background-color: transparent">KNOW
ALL PERSONS BY THESE PRESENTS, that each person whose signature appears below hereby constitutes and appoints Stephen Christopher
Linthwaite and Vikram Jog, and each of them severally, as his or her true and lawful attorneys-in-fact and agents, with full power
of substitution and resubstitution, for him or her and in his or her name, place and stead, in any and all capacities, to sign
the Registration Statement on Form S-8 of Fluidigm Corporation, and to sign, date and file any and all amendments thereto (including
post-effective amendments to this Registration Statement, in each case on his or her behalf, in any and all capacities stated below,
as appropriate, in such forms as they or any one of them may approve), and to file the same, with all exhibits thereto, and other
documents in connection therewith, with the Securities and Exchange Commission, granting unto said attorneys-in-fact and agents,
and each of them, full power and authority to do and perform each and every act and thing requisite and necessary to be done to
the end that such Registration Statement or Registration Statements shall comply with the Securities Act of 1933, as amended, and
the applicable Rules and Regulations adopted or issued pursuant thereto, as fully for all intents and purposes as he or she might
or could do in person, hereby and about the premises hereby ratifying and confirming all that said attorneys-in-fact and agent,
proxy and agent, or his, her or their substitute or substitutes, may lawfully do or cause to be done by virtue hereof, and generally
to do all such things on their behalf in their capacities as officers and directors to enable the Registrant to comply with the
provisions of the Securities Act of 1933, and all requirements of the Securities and Exchange Commission..</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.5in; background-color: transparent">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.5in; background-color: transparent">Pursuant
to the requirements of the Securities Act of 1933, this Registration Statement on Form S-8 has been signed by the following persons
in the capacities and on the dates indicated.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0in; background-color: transparent">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
<tr style="background-color: white">
    <TD STYLE="vertical-align: bottom; width: 39%; border-bottom: Black 1pt solid; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center"><FONT STYLE="font-size: 8pt"><B>Signature</B></FONT></td>
    <TD STYLE="vertical-align: top; width: 2%; text-align: center"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></td>
    <TD STYLE="vertical-align: bottom; width: 40%; border-bottom: Black 1pt solid; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center"><FONT STYLE="font-size: 8pt"><B>Title</B></FONT></td>
    <TD STYLE="vertical-align: top; width: 2%; text-align: center"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></td>
    <TD STYLE="vertical-align: bottom; width: 17%; border-bottom: Black 1pt solid; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center"><FONT STYLE="font-size: 8pt"><B>Date</B></FONT></td></tr>
<tr style="background-color: white">
    <TD STYLE="vertical-align: bottom; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center">&nbsp;</td>
    <TD STYLE="vertical-align: top; text-align: center">&nbsp;</td>
    <TD STYLE="padding-right: 5.4pt; padding-left: 5.4pt; text-align: center">&nbsp;</td>
    <TD STYLE="vertical-align: top; text-align: center">&nbsp;</td>
    <TD STYLE="padding-right: 5.4pt; padding-left: 5.4pt; text-align: center">&nbsp;</td></tr>
<tr style="vertical-align: bottom; background-color: white">
    <TD STYLE="border-bottom: Black 1pt solid; padding-right: 5.4pt; padding-left: 20pt; text-align: left">/s/ Stephen Christopher
    Linthwaite</td>
    <TD STYLE="text-align: center">&nbsp;</td>
    <TD STYLE="padding-right: 5.4pt; padding-left: 5.4pt; text-align: center">President, Chief Executive Officer, and Director
    </td>
    <TD STYLE="text-align: center">&nbsp;</td>
    <TD STYLE="padding-right: 5.4pt; padding-left: 5.4pt; text-align: center">August 3,
    2017</td></tr>
<tr style="vertical-align: bottom; background-color: white">
    <TD STYLE="padding-right: 5.4pt; padding-left: 5.4pt; text-align: center">Stephen Christopher Linthwaite</td>
    <TD STYLE="text-align: center">&nbsp;</td>
    <TD STYLE="padding-right: 5.4pt; padding-left: 5.4pt; text-align: center">&nbsp;(Principal Executive Officer)</td>
    <TD STYLE="text-align: center">&nbsp;</td>
    <TD STYLE="padding-right: 5.4pt; padding-left: 5.4pt; text-align: center">&nbsp;</td></tr>
<tr style="vertical-align: bottom; background-color: white">
    <TD STYLE="padding-right: 5.4pt; padding-left: 5.4pt; text-align: center">&nbsp;</td>
    <TD STYLE="text-align: center">&nbsp;</td>
    <TD STYLE="padding-right: 5.4pt; padding-left: 5.4pt; text-align: center">&nbsp;</td>
    <TD STYLE="text-align: center">&nbsp;</td>
    <TD STYLE="padding-right: 5.4pt; padding-left: 5.4pt; text-align: center">&nbsp;</td></tr>
<tr style="vertical-align: bottom; background-color: white">
    <TD STYLE="border-bottom: Black 1pt solid; padding-right: 5.4pt; padding-left: 20pt; text-align: left">/s/ Vikram Jog</td>
    <TD STYLE="text-align: center">&nbsp;</td>
    <TD STYLE="padding-right: 5.4pt; padding-left: 5.4pt; text-align: center">Chief Financial Officer </td>
    <TD STYLE="text-align: center">&nbsp;</td>
    <TD STYLE="padding-right: 5.4pt; padding-left: 5.4pt; text-align: center">August&nbsp;3,
    2017</td></tr>
<tr style="vertical-align: bottom; background-color: white">
    <TD STYLE="padding-right: 5.4pt; padding-left: 5.4pt; text-align: center">Vikram Jog</td>
    <TD STYLE="text-align: center">&nbsp;</td>
    <TD STYLE="padding-right: 5.4pt; padding-left: 5.4pt; text-align: center">&nbsp;(Principal Financial Officer)</td>
    <TD STYLE="text-align: center">&nbsp;</td>
    <TD STYLE="padding-right: 5.4pt; padding-left: 5.4pt; text-align: center">&nbsp;</td></tr>
<tr style="vertical-align: bottom; background-color: white">
    <TD STYLE="padding-right: 5.4pt; padding-left: 5.4pt; text-align: center">&nbsp;</td>
    <TD STYLE="text-align: center">&nbsp;</td>
    <TD STYLE="padding-right: 5.4pt; padding-left: 5.4pt; text-align: center">&nbsp;</td>
    <TD STYLE="text-align: center">&nbsp;</td>
    <TD STYLE="padding-right: 5.4pt; padding-left: 5.4pt; text-align: center">&nbsp;</td></tr>
<tr style="vertical-align: bottom; background-color: white">
    <TD STYLE="border-bottom: Black 1pt solid; padding-right: 5.4pt; padding-left: 20pt; text-align: left">/s/ Jennifer Lee</td>
    <TD STYLE="text-align: center">&nbsp;</td>
    <TD STYLE="padding-right: 5.4pt; padding-left: 5.4pt; text-align: center">Vice President, Controller</td>
    <TD STYLE="text-align: center">&nbsp;</td>
    <TD STYLE="padding-right: 5.4pt; padding-left: 5.4pt; text-align: center">August 3,
    2017</td></tr>
<tr style="vertical-align: bottom; background-color: white">
    <TD STYLE="padding-right: 5.4pt; padding-left: 5.4pt; text-align: center">Jennifer Lee</td>
    <TD STYLE="text-align: center">&nbsp;</td>
    <TD STYLE="padding-right: 5.4pt; padding-left: 5.4pt; text-align: center">&nbsp;(Principal Accounting Officer)</td>
    <TD STYLE="text-align: center">&nbsp;</td>
    <TD STYLE="padding-right: 5.4pt; padding-left: 5.4pt; text-align: center">&nbsp;</td></tr>
<tr style="vertical-align: bottom; background-color: white">
    <TD STYLE="padding-right: 5.4pt; padding-left: 5.4pt; text-align: center">&nbsp;</td>
    <TD STYLE="text-align: center">&nbsp;</td>
    <TD STYLE="padding-right: 5.4pt; padding-left: 5.4pt; text-align: center">&nbsp;</td>
    <TD STYLE="text-align: center">&nbsp;</td>
    <TD STYLE="padding-right: 5.4pt; padding-left: 5.4pt; text-align: center">&nbsp;</td></tr>
<tr style="vertical-align: bottom; background-color: white">
    <TD STYLE="border-bottom: Black 1pt solid; padding-right: 5.4pt; padding-left: 20pt; text-align: left">/s/ Samuel D. Colella</td>
    <TD STYLE="text-align: center">&nbsp;</td>
    <TD STYLE="padding-right: 5.4pt; padding-left: 5.4pt; text-align: center">Chairman of the Board of Directors</td>
    <TD STYLE="text-align: center">&nbsp;</td>
    <TD STYLE="padding-right: 5.4pt; padding-left: 5.4pt; text-align: center">August 3,
    2017</td></tr>
<tr style="vertical-align: bottom; background-color: white">
    <TD STYLE="padding-right: 5.4pt; padding-left: 5.4pt; text-align: center">Samuel D. Colella</td>
    <TD STYLE="text-align: center">&nbsp;</td>
    <TD STYLE="padding-right: 5.4pt; padding-left: 5.4pt; text-align: center">&nbsp;</td>
    <TD STYLE="text-align: center">&nbsp;</td>
    <TD STYLE="padding-right: 5.4pt; padding-left: 5.4pt; text-align: center">&nbsp;</td></tr>
<tr style="vertical-align: bottom; background-color: white">
    <TD STYLE="padding-right: 5.4pt; padding-left: 5.4pt; text-align: center">&nbsp;</td>
    <TD STYLE="text-align: center">&nbsp;</td>
    <TD STYLE="padding-right: 5.4pt; padding-left: 5.4pt; text-align: center">&nbsp;</td>
    <TD STYLE="text-align: center">&nbsp;</td>
    <TD STYLE="padding-right: 5.4pt; padding-left: 5.4pt; text-align: center">&nbsp;</td></tr>
<tr style="vertical-align: bottom; background-color: white">
    <TD STYLE="border-bottom: Black 1pt solid; padding-right: 5.4pt; padding-left: 20pt; text-align: left">/s/ Gerhard F. Burbach</td>
    <TD STYLE="text-align: center">&nbsp;</td>
    <TD STYLE="padding-right: 5.4pt; padding-left: 5.4pt; text-align: center">Director</td>
    <TD STYLE="text-align: center">&nbsp;</td>
    <TD STYLE="padding-right: 5.4pt; padding-left: 5.4pt; text-align: center">August 3,
    2017</td></tr>
<tr style="vertical-align: bottom; background-color: white">
    <TD STYLE="padding-right: 5.4pt; padding-left: 5.4pt; text-align: center">Gerhard F. Burbach</td>
    <TD STYLE="text-align: center">&nbsp;</td>
    <TD STYLE="padding-right: 5.4pt; padding-left: 5.4pt; text-align: center">&nbsp;</td>
    <TD STYLE="text-align: center">&nbsp;</td>
    <TD STYLE="padding-right: 5.4pt; padding-left: 5.4pt; text-align: center">&nbsp;</td></tr>
<tr style="vertical-align: bottom; background-color: white">
    <TD STYLE="padding-right: 5.4pt; padding-left: 5.4pt; text-align: center">&nbsp;</td>
    <TD STYLE="text-align: center">&nbsp;</td>
    <TD STYLE="padding-right: 5.4pt; padding-left: 5.4pt; text-align: center">&nbsp;</td>
    <TD STYLE="text-align: center">&nbsp;</td>
    <TD STYLE="padding-right: 5.4pt; padding-left: 5.4pt; text-align: center">&nbsp;</td></tr>
<tr style="vertical-align: bottom; background-color: white">
    <TD STYLE="border-bottom: Black 1pt solid; padding-right: 5.4pt; padding-left: 20pt; text-align: left">/s/ Carlos Paya</td>
    <TD STYLE="text-align: center">&nbsp;</td>
    <TD STYLE="padding-right: 5.4pt; padding-left: 5.4pt; text-align: center">Director</td>
    <TD STYLE="text-align: center">&nbsp;</td>
    <TD STYLE="padding-right: 5.4pt; padding-left: 5.4pt; text-align: center">August 3,
    2017</td></tr>
<tr style="vertical-align: bottom; background-color: white">
    <TD STYLE="padding-right: 5.4pt; padding-left: 5.4pt; text-align: center">Carlos Paya</td>
    <TD STYLE="text-align: center">&nbsp;</td>
    <TD STYLE="padding-right: 5.4pt; padding-left: 5.4pt; text-align: center">&nbsp;</td>
    <TD STYLE="text-align: center">&nbsp;</td>
    <TD STYLE="padding-right: 5.4pt; padding-left: 5.4pt; text-align: center">&nbsp;</td></tr>
<tr style="vertical-align: bottom; background-color: white">
    <TD STYLE="padding-right: 5.4pt; padding-left: 5.4pt; text-align: center">&nbsp;</td>
    <TD STYLE="text-align: center">&nbsp;</td>
    <TD STYLE="padding-right: 5.4pt; padding-left: 5.4pt; text-align: center">&nbsp;</td>
    <TD STYLE="text-align: center">&nbsp;</td>
    <TD STYLE="padding-right: 5.4pt; padding-left: 5.4pt; text-align: center">&nbsp;</td></tr>
<tr style="vertical-align: bottom; background-color: white">
    <TD STYLE="border-bottom: Black 1pt solid; padding-right: 5.4pt; padding-left: 20pt; text-align: left">/s/ Patrick S. Jones</td>
    <TD STYLE="text-align: center">&nbsp;</td>
    <TD STYLE="padding-right: 5.4pt; padding-left: 5.4pt; text-align: center">Director</td>
    <TD STYLE="text-align: center">&nbsp;</td>
    <TD STYLE="padding-right: 5.4pt; padding-left: 5.4pt; text-align: center">August 3,
    2017</td></tr>
<tr style="vertical-align: bottom; background-color: white">
    <TD STYLE="padding-right: 5.4pt; padding-left: 5.4pt; text-align: center">Patrick S. Jones</td>
    <TD STYLE="text-align: center">&nbsp;</td>
    <TD STYLE="padding-right: 5.4pt; padding-left: 5.4pt; text-align: center">&nbsp;</td>
    <TD STYLE="text-align: center">&nbsp;</td>
    <TD STYLE="padding-right: 5.4pt; padding-left: 5.4pt; text-align: center">&nbsp;</td></tr>
<tr style="vertical-align: bottom; background-color: white">
    <TD STYLE="padding-right: 5.4pt; padding-left: 5.4pt; text-align: center">&nbsp;</td>
    <TD STYLE="text-align: center">&nbsp;</td>
    <TD STYLE="padding-right: 5.4pt; padding-left: 5.4pt; text-align: center">&nbsp;</td>
    <TD STYLE="text-align: center">&nbsp;</td>
    <TD STYLE="padding-right: 5.4pt; padding-left: 5.4pt; text-align: center">&nbsp;</td></tr>
<tr style="vertical-align: bottom; background-color: white">
    <TD STYLE="border-bottom: Black 1pt solid; padding-right: 5.4pt; padding-left: 20pt; text-align: left">/s/ Nicolas Barthelemy</td>
    <TD STYLE="text-align: center">&nbsp;</td>
    <TD STYLE="padding-right: 5.4pt; padding-left: 5.4pt; text-align: center">Director</td>
    <TD STYLE="text-align: center">&nbsp;</td>
    <TD STYLE="padding-right: 5.4pt; padding-left: 5.4pt; text-align: center">August 3,
    2017</td></tr>
<tr style="vertical-align: bottom; background-color: white">
    <TD STYLE="padding-right: 5.4pt; padding-left: 5.4pt; text-align: center">Nicolas Barthelemy</td>
    <TD STYLE="text-align: center">&nbsp;</td>
    <TD STYLE="padding-right: 5.4pt; padding-left: 5.4pt; text-align: center">&nbsp;</td>
    <TD STYLE="text-align: center">&nbsp;</td>
    <TD STYLE="padding-right: 5.4pt; padding-left: 5.4pt; text-align: center">&nbsp;</td></tr>
</table>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0in; background-color: transparent">&nbsp;</P>


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<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; background-color: transparent">EXHIBIT
INDEX</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0in; background-color: transparent">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
<tr style="vertical-align: bottom; background-color: white">
    <TD COLSPAN="2" STYLE="border-bottom: Black 1pt solid; padding-right: 5.75pt; padding-left: 5.75pt; text-align: center"><FONT STYLE="font-size: 8pt"><B>Exhibit</B><br>
    <B>Number</B></FONT></td>
    <TD STYLE="text-align: center; padding-bottom: 1pt"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></td>
    <TD STYLE="border-bottom: Black 1pt solid; padding-right: 5.75pt; padding-left: 5.75pt; text-align: center"><FONT STYLE="font-size: 8pt"><B>Description</B></FONT></td>
    <TD STYLE="text-align: center; padding-bottom: 1pt"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></td>
    <TD STYLE="border-bottom: Black 1pt solid; text-align: center"><FONT STYLE="font-size: 8pt"><B>Incorporated</B><br>
    <B>by Reference</B><br>
    <B>From Form</B></FONT></td>
    <TD STYLE="text-align: center; padding-bottom: 1pt"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></td>
    <TD STYLE="border-bottom: Black 1pt solid; text-align: center"><FONT STYLE="font-size: 8pt"><B>Incorporated</B><br>
    <B>by Reference</B><br>
    <B>From Exhibit</B><br>
    <B>Number</B></FONT></td>
    <TD STYLE="text-align: center; padding-bottom: 1pt"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></td>
    <TD STYLE="border-bottom: Black 1pt solid; text-align: center"><FONT STYLE="font-size: 8pt"><B>Date Filed</B></FONT></td></tr>
<tr style="vertical-align: top; background-color: white">
    <TD STYLE="text-align: right; width: 5%">4.1</TD>
    <TD STYLE="text-align: left; width: 4%">&nbsp;</TD>
    <TD STYLE="width: 2%">&nbsp;</td>
    <TD STYLE="width: 45%">Specimen Common Stock Certificate of the Registrant.</td>
    <TD STYLE="width: 2%">&nbsp;</td>
    <TD STYLE="width: 14%; text-align: center">Filed herewith.</td>
    <TD STYLE="width: 2%">&nbsp;</td>
    <TD STYLE="width: 12%">&nbsp;</td>
    <TD STYLE="width: 2%">&nbsp;</td>
    <TD STYLE="width: 12%">&nbsp;</td></tr>
<tr style="vertical-align: top; background-color: white">
    <TD STYLE="text-align: right">4.2</TD>
    <TD STYLE="text-align: left">+</TD>
    <TD>&nbsp;</td>
    <TD>2017 Employee Stock Purchase Plan.</td>
    <TD>&nbsp;</td>
    <TD STYLE="text-align: center">8-K</td>
    <TD>&nbsp;</td>
    <TD STYLE="text-align: center">10.1</td>
    <TD>&nbsp;</td>
    <TD STYLE="text-align: center">8/2/2017</td></tr>
<tr style="vertical-align: top; background-color: white">
    <TD STYLE="text-align: right">4.5</TD>
    <TD STYLE="text-align: left">&nbsp;</TD>
    <TD>&nbsp;</td>
    <TD>Indenture, dated February 4, 2014, by and between Fluidigm Corporation and U.S. Bank National Association.</td>
    <TD>&nbsp;</td>
    <TD STYLE="text-align: center">8-K</td>
    <TD>&nbsp;</td>
    <TD STYLE="text-align: center">4.1</td>
    <TD>&nbsp;</td>
    <TD STYLE="text-align: center">2/4/2014</td></tr>
<tr style="vertical-align: top; background-color: white">
    <TD STYLE="text-align: right">4.6</TD>
    <TD STYLE="text-align: left">&nbsp;</TD>
    <TD>&nbsp;</td>
    <TD>First Supplement Indenture, dated February 4, 2014, by and between Fluidigm Corporation and U.S. Bank National Association.</td>
    <TD>&nbsp;</td>
    <TD STYLE="text-align: center">8-K</td>
    <TD>&nbsp;</td>
    <TD STYLE="text-align: center">4.2</td>
    <TD>&nbsp;</td>
    <TD STYLE="text-align: center">2/4/2014</td></tr>
<tr style="vertical-align: top; background-color: white">
    <TD STYLE="text-align: right">4.7</TD>
    <TD STYLE="text-align: left">&nbsp;</TD>
    <TD>&nbsp;</td>
    <TD>Form of Global Note (included in Exhibit 4.6).</td>
    <TD>&nbsp;</td>
    <TD STYLE="text-align: center">8-K</td>
    <TD>&nbsp;</td>
    <TD STYLE="text-align: center">4.3</td>
    <TD>&nbsp;</td>
    <TD STYLE="text-align: center">2/4/2014</td></tr>
<tr style="vertical-align: top; background-color: white">
    <TD STYLE="text-align: right">5.1</TD>
    <TD STYLE="text-align: left">&nbsp;</TD>
    <TD>&nbsp;</td>
    <TD>Opinion of Wilson Sonsini Goodrich &amp; Rosati, Professional Corporation.</td>
    <TD>&nbsp;</td>
    <TD STYLE="text-align: center">Filed herewith.</td>
    <TD>&nbsp;</td>
    <TD>&nbsp;</td>
    <TD>&nbsp;</td>
    <TD>&nbsp;</td></tr>
<tr style="vertical-align: top; background-color: white">
    <TD STYLE="text-align: right">23.1</TD>
    <TD STYLE="text-align: left">&nbsp;</TD>
    <TD>&nbsp;</td>
    <TD>Consent of PricewaterhouseCoopers LLP, Independent Registered Public Accounting Firm.</td>
    <TD>&nbsp;</td>
    <TD STYLE="text-align: center">Filed herewith.</td>
    <TD>&nbsp;</td>
    <TD>&nbsp;</td>
    <TD>&nbsp;</td>
    <TD>&nbsp;</td></tr>
<tr style="vertical-align: top; background-color: white">
    <TD STYLE="text-align: right">23.2</TD>
    <TD STYLE="text-align: left">&nbsp;</TD>
    <TD>&nbsp;</td>
    <TD>Consent of Ernst &amp; Young LLP, Independent Registered Public Accounting Firm.</td>
    <TD>&nbsp;</td>
    <TD STYLE="text-align: center">Filed herewith.</td>
    <TD>&nbsp;</td>
    <TD>&nbsp;</td>
    <TD>&nbsp;</td>
    <TD>&nbsp;</td></tr>
<tr style="vertical-align: top; background-color: white">
    <TD STYLE="text-align: right">23.3</TD>
    <TD STYLE="text-align: left">&nbsp;</TD>
    <TD>&nbsp;</td>
    <TD>Consent of Wilson Sonsini Goodrich &amp; Rosati, Professional Corporation (contained in Exhibit 5.1 hereto).</td>
    <TD>&nbsp;</td>
    <TD>&nbsp;</td>
    <TD>&nbsp;</td>
    <TD>&nbsp;</td>
    <TD>&nbsp;</td>
    <TD>&nbsp;</td></tr>
<tr style="vertical-align: top; background-color: white">
    <TD STYLE="text-align: right">24.1</TD>
    <TD STYLE="text-align: left">&nbsp;</TD>
    <TD>&nbsp;</td>
    <TD>Power of Attorney (contained on signature page hereto).</td>
    <TD>&nbsp;</td>
    <TD>&nbsp;</td>
    <TD>&nbsp;</td>
    <TD>&nbsp;</td>
    <TD>&nbsp;</td>
    <TD>&nbsp;</td></tr>
</table>
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Indicates management contract or compensatory plan, contract or arrangement.</FONT></P>

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[{"type": "S-8", "sequence": "1", "filename": "t1702250_s8.htm", "description": "FORM S-8", "secsgml_size_bytes": 84442}]
{"company-data": {"conformed-name": "FLUIDIGM CORP", "cik": "0001162194", "assigned-sic": "3826", "irs-number": "770513190", "state-of-incorporation": "DE", "fiscal-year-end": "1231"}, "filing-values": {"form-type": "S-8", "act": "33", "file-number": "333-219667", "film-number": "171005712"}, "business-address": {"street1": "7000 SHORELINE COURT", "street2": "SUITE 100", "city": "SOUTH SAN FRANCISCO", "state": "CA", "zip": "94080", "phone": "6502666000"}, "mail-address": {"street1": "7000 SHORELINE COURT", "street2": "SUITE 100", "city": "SOUTH SAN FRANCISCO", "state": "CA", "zip": "94080"}}
As filed
with the Securities and Exchange Commission on August 3, 2017
Registration
No. 333-
UNITED
STATES
SECURITIES
AND EXCHANGE COMMISSION
Washington,
D.C. 20549
FORM
S-8
REGISTRATION
STATEMENT
UNDER
THE
SECURITIES ACT OF 1933
FLUIDIGM
CORPORATION
(Exact
name of Registrant as specified in its charter)
Delaware
77-0513190
(State or other jurisdiction of
incorporation or organization)
(I.R.S. Employer
Identification No.)
7000
Shoreline Court, Suite 100
South
San Francisco, California 94080
(650)
266-6000
(Address
of principal executive offices, including zip code)
Fluidigm
Corporation 2017 Employee Stock Purchase Plan
(Full
title of the plan)
Stephen
Christopher Linthwaite
President
and Chief Executive Officer
7000
Shoreline Court, Suite 100
South
San Francisco, California 94080
(650)
266-6000
(Name,
address and telephone number, including area code, of agent for service)
Copies
to:
Nicholas
Khadder
General
Counsel
7000
Shoreline Court, Suite 100
South
San Francisco, California 94080
Telephone:
(650) 266-6000
Robert
F. Kornegay
Wilson
Sonsini Goodrich & Rosati,
Professional
Corporation
650
Page Mill Road
Palo
Alto, California 94304
Telephone:
(650) 493-9300
Indicate
by check mark whether the registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, a smaller reporting
company, or an emerging growth company. See the definitions of "large accelerated filer," "accelerated filer,"
"smaller reporting company," and "emerging growth company" in Rule 12b-2 of the Exchange Act.
Large accelerated filer
¨
Accelerated filer
x
Non-accelerated filer
¨
(Do     not check if a smaller reporting company)
Smaller reporting company
¨
Emerging growth company
¨
If
an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for
complying with any new or revised financial accounting standards provided pursuant to Section 7(a)(2)(B) of the Securities Act.
☐
CALCULATION
OF REGISTRATION FEE
Title of Securities to be Registered
Amount
to be Registered
(1)
Proposed
Maximum Offering
Price Per Share
Proposed
Maximum Aggregate
Offering Price
Amount of
Registration Fee
Common Stock, $0.001 par value per share, reserved for issuance pursuant to the Fluidigm Corporation 2017 Employee Stock Purchase Plan
1,000,000
$
3.28
(2)
$
3,280,000.00
$
380.15
TOTAL:
1,000,000
$
3,280,000.00
$
380.15
(1)
Pursuant to Rule 416(a) of the Securities Act of 1933,
as amended, this Registration Statement shall also cover any additional shares of the Registrant's common stock that become
issuable under the Fluidigm Corporation 2017 Employee Stock Purchase Plan (the "2017 ESPP") by reason of any stock
dividend, stock split, recapitalization or other similar transaction effected without receipt of consideration that increases
the number of the Registrant's outstanding shares of common stock.
(2)
Estimated in accordance with Rule 457(h) solely for the
purpose of calculating the total registration fee. Computation based upon 85% (see explanation in following sentence) of $3.85,
the average of the high and low prices of the Registrant's common stock as reported on the Nasdaq Global Select Market on
July 28, 2017. Pursuant to the 2017 ESPP, the purchase price of the shares of common stock reserved for issuance thereunder will
be 85% of the lower of the fair market value of the common stock on (i) the first trading day of the offering period or (ii) the
exercise date.
FLUIDIGM
CORPORATION
EXPLANATORY
NOTE
This Registration
Statement is filed by Fluidigm Corporation (the "Registrant") for the purpose of registering 1,000,000 shares of common
stock of the Registrant that are currently reserved for issuance under the Fluidigm Corporation 2017 Employee Stock Purchase Plan.
PART
I
INFORMATION
REQUIRED IN THE PROSPECTUS
The
information specified in Item 1 and Item 2 of Part I of Form S-8 is omitted from this Registration Statement on Form S-8 (the "Registration
Statement") in accordance with the provisions of Rule 428 under the Securities Act of 1933, as amended (the "Securities
Act"), and the introductory note to Part I of Form S-8. The documents containing the information specified in Part I of Form
S-8 will be delivered to the participants in the equity benefit plan covered by this Registration Statement as specified by Rule
428(b)(1) under the Securities Act.
PART
II
INFORMATION
REQUIRED IN REGISTRATION STATEMENT
Item
3.  Incorporation of Documents by Reference.
The
Registrant hereby incorporates by reference into this Registration Statement the following documents previously filed with the
Commission:
(1)
The Registrant's Annual Report on Form 10-K for the fiscal year ended December 31, 2016, filed with the Commission on
March 3, 2017 and the Registrant's Amendment No. 1 to the Registrant's Form 10-K, filed with the Commission on April
28, 2017;
(2)
The Registrant's Quarterly Report on Form 10-Q for the three months ended March 31, 2017, filed with the Commission on
May 9, 2017;
(3)
The Registrant's Current Reports on Form 8-K filed with
                                         the Commission on January 11, 2017, February 10, 2017, March 2, 2017, March 27, 2017,
                                         May 24, 2017, August 2, 2017, August 2, 2017, August 3, 2017, and
                                         August 3, 2017 only to the extent that the items therein are specifically stated
                                         to be "filed" rather than "furnished" for the purposes of Section
                                         18 of the Securities Exchange Act of 1934, as amended (the "Exchange Act");
                                         and
(4)
The description of the Registrant's common stock contained in the Company's Registration Statements on Form 8-A
(File No. 001-34180) filed with the Commission on February 7, 2011, pursuant to Section 12(b) of the Exchange Act, including any
amendment or report filed for the purpose of updating such description.
All documents
filed by the Registrant pursuant to Sections 13(a), 13(c), 14 and 15(d) of the Exchange Act on or after the date of this Registration
Statement and prior to the filing of a post-effective amendment to this Registration Statement that indicates that all securities
offered have been sold or that deregisters all securities then remaining unsold shall be deemed to be incorporated by reference
in this Registration Statement and to be part hereof from the date of filing of such documents;
provided
,
however
,
that documents or information deemed to have been furnished and not filed in accordance with the rules of the Commission shall
not be deemed incorporated by reference into this Registration Statement. Any statement contained in a document incorporated or
deemed to be incorporated by reference herein shall be deemed to be modified or superseded for purposes of this Registration Statement
to the extent that a statement contained herein or in any subsequently filed document which also is deemed to be incorporated by
reference herein modifies or supersedes such statement. Any such statement so modified or superseded shall not be deemed, except
as so modified or superseded, to constitute a part of this Registration Statement.
Under no
circumstances will any information furnished under current items 2.02 or 7.01 of Form 8-K be deemed incorporated herein by reference
unless such Form 8-K expressly provides to the contrary.
Item
4.  Description of Securities.
Not
applicable.
Item 5.  Interests
of Named Experts and Counsel.
Not applicable.
Item 6.  Indemnification
of Directors and Officers.
Section 145 of
the Delaware General Corporation Law authorizes a corporation's board of directors to grant, and authorizes a court to award,
indemnity to officers, directors, and other corporate agents.
As permitted by
Section 102(b)(7) of the Delaware General Corporation Law, the Registrant's certificate of incorporation includes provisions
that eliminate the personal liability of its directors and officers for monetary damages for breach of their fiduciary duty as
directors and officers.
In addition, as
permitted by Section 145 of the Delaware General Corporation Law, the bylaws of the Registrant provide that:
·
The Registrant shall indemnify its directors and officers for serving the Registrant in those capacities or for serving other
business enterprises at the Registrant's request, to the fullest extent permitted by Delaware law. Delaware law provides
that a corporation may indemnify such person if such person acted in good faith and in a manner such person reasonably believed
to be in or not opposed to the best interests of the Registrant and, with respect to any criminal proceeding, had no reasonable
cause to believe such person's conduct was unlawful.
·
The Registrant may, in its discretion, indemnify employees and agents in those circumstances where indemnification is not required
by law.
·
The Registrant is required to advance expenses, as incurred, to its directors and officers in connection with defending a proceeding,
except that such director or officer shall undertake to repay such advances if it is ultimately determined that such person is
not entitled to indemnification.
·
The Registrant will not be obligated pursuant to the bylaws to indemnify a person with respect to proceedings initiated by
that person, except with respect to proceedings authorized by the Registrant's board of directors or brought to enforce a
right to indemnification.
·
The rights conferred in the bylaws are not exclusive, and the Registrant is authorized to enter into indemnification agreements
with its directors, officers, employees, and agents and to obtain insurance to indemnify such persons.
·
The Registrant may not retroactively amend the bylaw provisions to reduce its indemnification obligations to directors, officers,
employees, and agents.
The Registrant's
policy is to enter into separate indemnification agreements with each of its directors and officers that provide the maximum indemnity
allowed to directors and executive officers by Section 145 of the Delaware General Corporation Law and also provides for certain
additional procedural protections. The Registrant also maintains directors and officers insurance to insure such persons against
certain liabilities.
These indemnification
provisions and the indemnification agreements entered into between the Registrant and its officers and directors may be sufficiently
broad to permit indemnification of the Registrant's officers and directors for liabilities (including reimbursement of expenses
incurred) arising under the Securities Act.
See also Registrant's
undertakings in Section 9 of this Registration Statement.
Item
7.  Exemption from Registration Claimed.
Not applicable.
Item
8.  Exhibits.
Exhibit
Number
Description
Incorporated
by Reference
From Form
Incorporated
by Reference
From Exhibit
Number
Date Filed
4.1
Specimen Common Stock Certificate of the Registrant.
Filed herewith.
4.2
+
2017 Employee Stock Purchase Plan.
8-K
10.1
8/2/2017
4.5
Indenture, dated February 4, 2014, by and between Fluidigm Corporation and U.S. Bank National Association.
8-K
4.1
2/4/2014
Exhibit
Number
Description
Incorporated
by Reference
From Form
Incorporated
by Reference
From Exhibit
Number
Date Filed
4.6
First Supplement Indenture, dated February 4, 2014, by and between Fluidigm Corporation and U.S. Bank National Association.
8-K
4.2
2/4/2014
4.7
Form of Global Note (included in Exhibit 4.6).
8-K
4.3
2/4/2014
5.1
Opinion of Wilson Sonsini Goodrich & Rosati, Professional Corporation.
Filed herewith.
23.1
Consent of PricewaterhouseCoopers LLP, Independent Registered Public Accounting Firm.
Filed herewith.
23.2
Consent of Ernst & Young LLP, Independent Registered Public Accounting Firm.
Filed herewith.
23.3
Consent of Wilson Sonsini Goodrich & Rosati, Professional Corporation (contained in Exhibit 5.1 hereto).
24.1
Power of Attorney (contained on signature page hereto).
+
Indicates management contract or compensatory plan, contract or arrangement.
Item
9.  Undertakings.
A. The undersigned
Registrant hereby undertakes:
(1) To
file, during any period in which offers or sales are being made, a post-effective amendment to this Registration Statement:
(i) To include
any prospectus required by Section 10(a)(3) of the Securities Act of 1933;
(ii) To reflect
in the prospectus any facts or events arising after the effective date of the registration statement (or the most recent post-effective
amendment thereof) which, individually or in the aggregate, represent a fundamental change in the information set forth in the
registration statement. Notwithstanding the foregoing, any increase or decrease in volume of securities offered (if the total dollar
value of securities offered would not exceed that which was registered) and any deviation from the low or high end of the estimated
maximum offering range may be reflected in the form of prospectus filed with the Commission pursuant to Rule 424(b) if, in the
aggregate, the changes in volume and price represent no more than 20% change in the maximum aggregate offering price set forth
in the "Calculation of Registration Fee" table in the effective registration statement;
(iii) To
include any material information with respect to the plan of distribution not previously disclosed in the Registration Statement
or any material change to such information in the Registration Statement.
Provided, however
,
that: (1) Paragraphs (A)(1)(i) and (A)(1)(ii) do not apply if the information required to be included in a post-effective amendment
by those paragraphs is contained in periodic reports filed with or furnished to the Commission by the Registrant pursuant to Section
13 or Section 15(d) of the Securities Exchange Act of 1934 that are incorporated by reference in this Registration Statement.
(2) That,
for the purpose of determining any liability under the Securities Act of 1933, each such post-effective amendment shall be deemed
to be a new registration statement relating to the securities offered herein, and the offering of such securities at that time
shall be deemed to be the initial bona fide offering thereof.
(3) To
remove from registration by means of a post-effective amendment any of the securities being registered which remain unsold at the
termination of the offering.
B. The undersigned
Registrant hereby undertakes that, for purposes of determining any liability under the Securities Act of 1933, each
filing of the Registrant's
annual report pursuant to Section 13(a) or Section 15(d) of the Securities Exchange Act of 1934 (and, where applicable, each filing
of an employee benefit plan's annual report pursuant to Section 15(d) of the Securities Exchange Act of 1934) that is incorporated
by reference in the Registration Statement shall be deemed to be a new registration statement relating to the securities offered
herein, and the offering of such securities at that time shall be deemed to be the initial bona fide offering thereof.
C. Insofar as indemnification
for liabilities arising under the Securities Act of 1933 may be permitted to directors, officers and controlling persons of the
Registrant pursuant to the foregoing provisions, or otherwise, the Registrant has been advised that in the opinion of the Securities
and Exchange Commission such indemnification is against public policy as expressed in the Act and is, therefore, unenforceable.
In the event that a claim for indemnification against such liabilities (other than the payment by the Registrant of expenses incurred
or paid by a director, officer or controlling person of the Registrant in the successful defense of any action, suit or proceeding)
is asserted by such director, officer or controlling person in connection with the securities being registered, the Registrant
will, unless in the opinion of its counsel the matter has been settled by controlling precedent, submit to a court of appropriate
jurisdiction the question whether such indemnification by it is against public policy as expressed in the Act and will be governed
by the final adjudication of such issue.
SIGNATURES
Pursuant
to the requirements of the Securities Act of 1933, the Registrant certifies that it has reasonable grounds to believe that it meets
all of the requirements for filing on Form S-8 and has duly caused this Registration Statement to be signed on its behalf by the
undersigned, thereunto duly authorized, in the City of South San Francisco, State of California, on August 3,
2017.
Fluidigm Corporation
By:
/s/ Stephen Christopher Linthwaite
Stephen Christopher Linthwaite
President and Chief Executive Officer
POWER
OF ATTORNEY
KNOW
ALL PERSONS BY THESE PRESENTS, that each person whose signature appears below hereby constitutes and appoints Stephen Christopher
Linthwaite and Vikram Jog, and each of them severally, as his or her true and lawful attorneys-in-fact and agents, with full power
of substitution and resubstitution, for him or her and in his or her name, place and stead, in any and all capacities, to sign
the Registration Statement on Form S-8 of Fluidigm Corporation, and to sign, date and file any and all amendments thereto (including
post-effective amendments to this Registration Statement, in each case on his or her behalf, in any and all capacities stated below,
as appropriate, in such forms as they or any one of them may approve), and to file the same, with all exhibits thereto, and other
documents in connection therewith, with the Securities and Exchange Commission, granting unto said attorneys-in-fact and agents,
and each of them, full power and authority to do and perform each and every act and thing requisite and necessary to be done to
the end that such Registration Statement or Registration Statements shall comply with the Securities Act of 1933, as amended, and
the applicable Rules and Regulations adopted or issued pursuant thereto, as fully for all intents and purposes as he or she might
or could do in person, hereby and about the premises hereby ratifying and confirming all that said attorneys-in-fact and agent,
proxy and agent, or his, her or their substitute or substitutes, may lawfully do or cause to be done by virtue hereof, and generally
to do all such things on their behalf in their capacities as officers and directors to enable the Registrant to comply with the
provisions of the Securities Act of 1933, and all requirements of the Securities and Exchange Commission..
Pursuant
to the requirements of the Securities Act of 1933, this Registration Statement on Form S-8 has been signed by the following persons
in the capacities and on the dates indicated.
Signature
Title
Date
/s/ Stephen Christopher
    Linthwaite
President, Chief Executive Officer, and Director
August 3,
    2017
Stephen Christopher Linthwaite
(Principal Executive Officer)
/s/ Vikram Jog
Chief Financial Officer
August 3,
    2017
Vikram Jog
(Principal Financial Officer)
/s/ Jennifer Lee
Vice President, Controller
August 3,
    2017
Jennifer Lee
(Principal Accounting Officer)
/s/ Samuel D. Colella
Chairman of the Board of Directors
August 3,
    2017
Samuel D. Colella
/s/ Gerhard F. Burbach
Director
August 3,
    2017
Gerhard F. Burbach
/s/ Carlos Paya
Director
August 3,
    2017
Carlos Paya
/s/ Patrick S. Jones
Director
August 3,
    2017
Patrick S. Jones
/s/ Nicolas Barthelemy
Director
August 3,
    2017
Nicolas Barthelemy
EXHIBIT
INDEX
Exhibit
Number
Description
Incorporated
by Reference
From Form
Incorporated
by Reference
From Exhibit
Number
Date Filed
4.1
Specimen Common Stock Certificate of the Registrant.
Filed herewith.
4.2
+
2017 Employee Stock Purchase Plan.
8-K
10.1
8/2/2017
4.5
Indenture, dated February 4, 2014, by and between Fluidigm Corporation and U.S. Bank National Association.
8-K
4.1
2/4/2014
4.6
First Supplement Indenture, dated February 4, 2014, by and between Fluidigm Corporation and U.S. Bank National Association.
8-K
4.2
2/4/2014
4.7
Form of Global Note (included in Exhibit 4.6).
8-K
4.3
2/4/2014
5.1
Opinion of Wilson Sonsini Goodrich & Rosati, Professional Corporation.
Filed herewith.
23.1
Consent of PricewaterhouseCoopers LLP, Independent Registered Public Accounting Firm.
Filed herewith.
23.2
Consent of Ernst & Young LLP, Independent Registered Public Accounting Firm.
Filed herewith.
23.3
Consent of Wilson Sonsini Goodrich & Rosati, Professional Corporation (contained in Exhibit 5.1 hereto).
24.1
Power of Attorney (contained on signature page hereto).
+
Indicates management contract or compensatory plan, contract or arrangement.