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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0.75in 0pt 51.1pt; text-align: center">As filed with the Securities
and Exchange Commission on February 15, 2018</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: right">Registration No. 333- &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center"><B>UNITED STATES</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center"><B>SECURITIES AND EXCHANGE
COMMISSION</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center">Washington, D.C. 20549</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center"><U>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;
</U></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center"><B>FORM S-8</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center">REGISTRATION STATEMENT</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center">UNDER</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center">THE SECURITIES ACT OF 1933</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center"><U>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;
</U></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center">&nbsp;</P>

<P STYLE="font: 24pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center"><B>Oncobiologics, Inc.</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center">(Exact name of Registrant
as specified in its charter)</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
<TR STYLE="vertical-align: top">
    <TD STYLE="width: 45%; text-align: center"><FONT STYLE="font-size: 10pt"><B>Delaware</B></FONT></TD>
    <TD STYLE="width: 10%; text-align: center">&nbsp;</TD>
    <TD STYLE="width: 45%; text-align: center"><FONT STYLE="font-size: 10pt"><B>38-3982704</B></FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: center"><FONT STYLE="font-size: 10pt">(State or other jurisdiction of Incorporation or organization)</FONT></TD>
    <TD STYLE="text-align: center">&nbsp;</TD>
    <TD STYLE="text-align: center"><FONT STYLE="font-size: 10pt">(I.R.S. Employer Identification No.)</FONT></TD></TR>
</TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center"><B>&nbsp;</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center"><B>7 Clarke Drive</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center"><B>Cranbury, New Jersey 08512</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center"><U>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;
</U></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center">(Address of principal executive offices)
(Zip code)</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center"><B>&nbsp;</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center"><B>2015 Equity Incentive Plan</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center"><B>2016 Employee Stock Purchase Plan</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center">_____________________________________</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center">(Full title of the plan)</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center"><B>Pankaj Mohan, Ph.D.</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center"><B>Chairman, President and Chief Executive
Officer</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center"><B>Oncobiologics, Inc.</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center"><B>7 Clarke Drive</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center"><B>Cranbury, New Jersey 08512</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center"><B>(609) 619-3990</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center"><U>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</U></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center">(Name and address of agent for service)
(Telephone number, including area code, of agent for service)</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center"><B><I>&nbsp;</I></B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B><I>Copies to:</I></B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B><I>&nbsp;</I></B></P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
<TR>
    <TD STYLE="width: 50%; text-align: center; vertical-align: top">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B>Yvan-Claude Pierre</B></P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B>Marianne C. Sarrazin</B></P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B>Cooley LLP</B></P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B>1114 Avenue of the Americas</B></P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B>New York, New York 10036</B></P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B>(212) 479-6000</B></P></TD>
    <TD STYLE="width: 50%; text-align: center; vertical-align: top">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><B>Lawrence A. Kenyon</B></P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B>Chief Financial Officer</B></P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B>Oncobiologics, Inc.</B></P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B>7 Clarke Drive</B></P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B>Cranbury, New Jersey 08512</B></P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B>(609) 619-3990</B></P></TD></TR>
</TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Indicate by check mark whether the registrant is a large accelerated
filer, an accelerated filer, a non-accelerated filer, a smaller reporting company, or an emerging growth company. See the definitions
of &ldquo;large accelerated filer,&rdquo; &ldquo;accelerated filer,&rdquo; &ldquo;smaller reporting company,&rdquo; and &ldquo;emerging
growth company&rdquo; in Rule 12b-2 of the Exchange Act.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B>&nbsp;</B></P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 95%; border-collapse: collapse; margin-left: 0.5in">
<TR STYLE="vertical-align: top">
    <TD STYLE="width: 69%; font-size: 10pt; text-align: justify"><FONT STYLE="font-size: 10pt">Large accelerated filer&nbsp;&nbsp;&nbsp;<FONT STYLE="font-family: Wingdings">&uml;</FONT></FONT></TD>
    <TD STYLE="width: 31%; font-size: 10pt; text-align: justify"><FONT STYLE="font-size: 10pt">Accelerated filer&nbsp;&nbsp;&nbsp;<FONT STYLE="font-family: Wingdings">&uml;</FONT></FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD NOWRAP STYLE="font-size: 10pt; text-align: justify"><FONT STYLE="font-size: 10pt">Non-accelerated filer&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<FONT STYLE="font-family: Wingdings">&uml;</FONT> (Do not check if a smaller reporting company)</FONT></TD>
    <TD STYLE="font-size: 10pt; text-align: justify"><FONT STYLE="font-size: 10pt">Smaller reporting company&nbsp;&nbsp;<FONT STYLE="font-family: Wingdings">&#120;</FONT></FONT></TD></TR>
</TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; text-align: left; margin-bottom: 0pt; margin-left: 0.5in">Emerging growth company <FONT STYLE="font-family: Wingdings"><FONT STYLE="font-family: Wingdings">&#120;</FONT></FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 27pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>CALCULATION OF REGISTRATION FEE</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="border-collapse: collapse; width: 100%; font: 10pt Times New Roman, Times, Serif">
<TR STYLE="vertical-align: bottom">
    <TD NOWRAP STYLE="font: 10pt Times New Roman, Times, Serif; text-align: center; border-bottom: Black 1pt solid; vertical-align: bottom"><P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>Title of Securities</B></P> <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>to be Registered</B></P></TD><TD NOWRAP STYLE="font-size: 10pt; font-weight: bold; padding-bottom: 1pt; text-align: center; vertical-align: bottom">&nbsp;</TD>
    <TD COLSPAN="2" NOWRAP STYLE="font-size: 10pt; font-weight: bold; text-align: center; border-bottom: Black 1pt solid; vertical-align: bottom">Amount to be<BR>
 Registered(1)</TD><TD NOWRAP STYLE="padding-bottom: 1pt; font-size: 10pt; font-weight: bold; text-align: center; vertical-align: bottom">&nbsp;</TD><TD NOWRAP STYLE="font: 10pt Times New Roman, Times, Serif; padding-bottom: 1pt; text-align: center; vertical-align: bottom">&nbsp;</TD>
    <TD COLSPAN="2" NOWRAP STYLE="font: 10pt Times New Roman, Times, Serif; text-align: center; border-bottom: Black 1pt solid; vertical-align: bottom"><P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>Proposed</B><BR>
<B>Maximum</B><BR>
<B>Offering<BR>
Price per<BR>
 Share(6)</B></P></TD><TD NOWRAP STYLE="padding-bottom: 1pt; font: 10pt Times New Roman, Times, Serif; text-align: center; vertical-align: bottom">&nbsp;</TD><TD NOWRAP STYLE="font: 10pt Times New Roman, Times, Serif; padding-bottom: 1pt; text-align: center; vertical-align: bottom">&nbsp;</TD>
    <TD COLSPAN="2" NOWRAP STYLE="font: 10pt Times New Roman, Times, Serif; text-align: center; border-bottom: Black 1pt solid; vertical-align: bottom"><P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>Proposed</B><BR>
<B>Maximum</B><BR>
<B>Aggregate<BR>
Offering<BR>
 Price(6)</B></P></TD><TD NOWRAP STYLE="padding-bottom: 1pt; font: 10pt Times New Roman, Times, Serif; text-align: center; vertical-align: bottom">&nbsp;</TD><TD NOWRAP STYLE="font: 10pt Times New Roman, Times, Serif; padding-bottom: 1pt; text-align: center; vertical-align: bottom">&nbsp;</TD>
    <TD COLSPAN="2" NOWRAP STYLE="font: 10pt Times New Roman, Times, Serif; text-align: center; border-bottom: Black 1pt solid; vertical-align: bottom"><P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>Amount
of<BR>
Registration<BR>
 Fee</B></P></TD><TD NOWRAP STYLE="padding-bottom: 1pt; font: 10pt Times New Roman, Times, Serif; text-align: center; vertical-align: bottom">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom">
    <TD STYLE="font-size: 10pt">Common Stock, par value $0.01 per share, reserved for issuance pursuant to the 2015 Equity Incentive Plan</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="font-size: 10pt; text-align: right">765,921</TD><TD STYLE="font-size: 10pt">(2)(3)</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">$</TD>
    <TD STYLE="font-size: 10pt; text-align: right">1.20</TD><TD STYLE="font-size: 10pt">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">$</TD>
    <TD STYLE="font-size: 10pt; text-align: right">919,105.20</TD><TD STYLE="font-size: 10pt">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">$</TD>
    <TD STYLE="font-size: 10pt; text-align: right">114.43</TD><TD STYLE="font-size: 10pt">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom">
    <TD STYLE="font-size: 10pt; padding-bottom: 1pt">Common Stock, par value $0.01 per share, reserved for issuance pursuant to the 2016 Employee Stock Purchase Plan</TD><TD STYLE="font-size: 10pt; padding-bottom: 1pt">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="font-size: 10pt; text-align: right; border-bottom: Black 1pt solid">255,307</TD><TD NOWRAP STYLE="padding-bottom: 1pt; font-size: 10pt">(4)(5)</TD><TD STYLE="font-size: 10pt; padding-bottom: 1pt">&nbsp;</TD>
    <TD STYLE="border-bottom: Black 1pt solid; font-size: 10pt; text-align: left">$</TD>
    <TD STYLE="border-bottom: Black 1pt solid; font-size: 10pt; text-align: right">1.20</TD><TD STYLE="padding-bottom: 1pt; font-size: 10pt">&nbsp;</TD><TD STYLE="font-size: 10pt; padding-bottom: 1pt">&nbsp;</TD>
    <TD STYLE="border-bottom: Black 1pt solid; font-size: 10pt; text-align: left">$</TD>
    <TD STYLE="border-bottom: Black 1pt solid; font-size: 10pt; text-align: right">306,368.40</TD><TD STYLE="padding-bottom: 1pt; font-size: 10pt">&nbsp;</TD><TD STYLE="font-size: 10pt; padding-bottom: 1pt">&nbsp;</TD>
    <TD STYLE="border-bottom: Black 1pt solid; font-size: 10pt; text-align: left">$</TD>
    <TD STYLE="border-bottom: Black 1pt solid; font-size: 10pt; text-align: right">38.14</TD><TD STYLE="padding-bottom: 1pt; font-size: 10pt">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom">
    <TD STYLE="width: 39%; font-size: 10pt; padding-bottom: 2.5pt">Total</TD><TD STYLE="width: 1%; font-size: 10pt; padding-bottom: 2.5pt">&nbsp;</TD>
    <TD STYLE="width: 1%; border-bottom: Black 2.5pt double; font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="width: 15%; border-bottom: Black 2.5pt double; font-size: 10pt; text-align: right">1,021,228</TD><TD STYLE="width: 2%; padding-bottom: 2.5pt; font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="width: 1%; font-size: 10pt; padding-bottom: 2.5pt">&nbsp;</TD>
    <TD STYLE="width: 1%; border-bottom: Black 2.5pt double; font-size: 10pt; text-align: left">$</TD><TD STYLE="width: 11%; border-bottom: Black 2.5pt double; font-size: 10pt; text-align: right">1.20</TD><TD STYLE="width: 1%; padding-bottom: 2.5pt; font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="width: 1%; font-size: 10pt; padding-bottom: 2.5pt">&nbsp;</TD>
    <TD STYLE="width: 1%; border-bottom: Black 2.5pt double; font-size: 10pt; text-align: left">$</TD><TD STYLE="width: 11%; border-bottom: Black 2.5pt double; font-size: 10pt; text-align: right">1,225,473.60</TD><TD STYLE="width: 1%; padding-bottom: 2.5pt; font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="width: 1%; font-size: 10pt; padding-bottom: 2.5pt">&nbsp;</TD>
    <TD STYLE="width: 1%; border-bottom: Black 2.5pt double; font-size: 10pt; text-align: left">$</TD><TD STYLE="width: 11%; border-bottom: Black 2.5pt double; font-size: 10pt; text-align: right">152.57</TD><TD STYLE="width: 1%; padding-bottom: 2.5pt; font-size: 10pt; text-align: left">&nbsp;</TD></TR>
</TABLE>


<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="border-collapse: collapse; width: 100%; font: 10pt Times New Roman, Times, Serif">
<TR STYLE="vertical-align: bottom">
    <TD NOWRAP STYLE="width: 5%; font-size: 10pt; text-align: left; vertical-align: top">(1)</TD><TD STYLE="width: 2%; font-size: 10pt; text-align: left; vertical-align: top">&nbsp;</TD>
    <TD STYLE="width: 93%; font-size: 10pt; text-align: left; vertical-align: top">Pursuant to Rule 416(a) promulgated under the Securities Act of 1933, as amended (the &ldquo;<B>Securities Act</B>&rdquo;), this Registration Statement shall also cover any additional shares of Registrant&rsquo;s common stock, par value $0.01 (the &ldquo;<B>Common Stock</B>&rdquo;), that become issuable under the 2015 Equity Incentive Plan (&ldquo;<B>2015 EIP</B>&rdquo;) or the 2016 Employee Stock Purchase Plan (&ldquo;<B>ESPP</B>&rdquo;), set forth herein by reason of any stock dividend, stock split, recapitalization or other similar transaction effected that results in an increase to the number of outstanding shares of Common Stock.</TD></TR>
<TR STYLE="vertical-align: bottom">
    <TD NOWRAP STYLE="font-size: 10pt; text-align: left; vertical-align: top">(2)</TD><TD STYLE="font-size: 10pt; text-align: left; vertical-align: top">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left; vertical-align: top">Represents additional shares of Common Stock reserved for future issuance under the 2015 EIP by reason of the automatic increase provision of the 2015 EIP.</TD></TR>
<TR STYLE="vertical-align: bottom">
    <TD NOWRAP STYLE="font-size: 10pt; text-align: left; vertical-align: top">(3)</TD><TD STYLE="font-size: 10pt; text-align: left; vertical-align: top">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left; vertical-align: top">The number of shares of Common Stock reserved for issuance under the 2015 EIP automatically increases on January 1st each year, starting on January 1, 2017 and continuing through January 1, 2026, by the lesser of (A) 3% of the total number of shares of Common Stock outstanding on December 31st of the immediately preceding calendar year, (B) 1,760,000 and (C) a number determined by the Registrant&rsquo;s board of directors.</TD></TR>
<TR STYLE="vertical-align: bottom">
    <TD NOWRAP STYLE="font-size: 10pt; text-align: left; vertical-align: top">(4)</TD><TD STYLE="font-size: 10pt; text-align: left; vertical-align: top">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left; vertical-align: top">Represents additional shares of Common Stock reserved for future issuance under the ESPP by reason of the automatic increase provision of the ESPP.</TD></TR>
<TR STYLE="vertical-align: bottom">
    <TD NOWRAP STYLE="font-size: 10pt; text-align: left; vertical-align: top">(5)</TD><TD STYLE="font-size: 10pt; text-align: left; vertical-align: top">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left; vertical-align: top">The number of shares of Common Stock reserved for issuance under the ESPP automatically increases on January 1st each year, starting on January 1, 2017 and continuing through January 1, 2026, by the lesser of (A) 1% of the total number of shares of Common Stock outstanding on December 31st of the immediately preceding calendar year and (B) a number determined by the Registrant&rsquo;s board of directors.</TD></TR>
<TR STYLE="vertical-align: bottom">
    <TD NOWRAP STYLE="font-size: 10pt; text-align: left; vertical-align: top">(6)</TD><TD STYLE="font-size: 10pt; text-align: left; vertical-align: top">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left; vertical-align: top">Estimated in accordance with Rule 457(h) under the Securities
    Act solely for the purpose of calculating the registration fee on the basis of $1.20, the average of the high and low
    prices of the Registrant&rsquo;s Common Stock as reported on the Nasdaq Global Market on February 13, 2018.</TD></TR>
</TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in; text-indent: -0.5in">&nbsp;</P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in; text-indent: -0.5in"></P>




<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in; text-align: center; text-indent: -0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in; text-align: center; text-indent: -0.5in"><B>EXPLANATORY
NOTE</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in; text-indent: -0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 24.5pt; background-color: white">Oncobiologics,
Inc. (the &ldquo;<B><I>Registrant</I></B>&rdquo;) is filing this Registration Statement on Form&nbsp;S-8 for the purpose of registering
an additional 765,921 shares of its Common Stock issuable to eligible persons under the 2015 EIP and an additional 255,307 shares
of its Common Stock issuable to eligible persons under the ESPP, in each case which Common Stock is in addition to the shares of
Common Stock registered on the Registrant&rsquo;s Form&nbsp;S-8s filed on May&nbsp;13, 2016 (File No.&nbsp;333-211362) and on February
15, 2017 (File No.&nbsp;333-216,081) (the &ldquo;<B><I>Prior Form S-8s</I></B>&rdquo;).</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>PART II </B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0"></TD><TD STYLE="width: 1in"><B>ITEM 3.</B></TD><TD><B>INCORPORATION OF CERTAIN DOCUMENTS BY REFERENCE</B></TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0in">Pursuant to General Instruction
E to Form S-8, the contents of the Prior Form S-8s filed by the Registrant are incorporated by reference herein. In addition, the
following documents filed by the Registrant with the Securities and Exchange Commission (&ldquo;<B><I>SEC</I></B>&rdquo;) are incorporated
by reference into this Registration Statement:</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.5in"><FONT STYLE="font-family: Times New Roman, Times, Serif"><B>(a)<FONT STYLE="font-size: 10pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;
</FONT></B></FONT>The Registrant&rsquo;s latest annual report on Form 10-K, filed with the SEC on December 29, 2017, as amended
January 29, 2018;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.5in"><B>(b)</B><FONT STYLE="font-size: 10pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;
</FONT>The Registrant&rsquo;s quarterly report on Form&nbsp;10-Q, filed with the SEC on February&nbsp;14, 2018;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.5in"><FONT STYLE="font-family: Times New Roman, Times, Serif"><B>(c)<FONT STYLE="font-size: 10pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;
</FONT></B></FONT>The Registrant&rsquo;s current reports on Form 8-K, filed with the SEC on October&nbsp;6, 2017, October&nbsp;31,
2017, January&nbsp;4, 2018, February&nbsp;7, 2018, February&nbsp;9, 2018, and February&nbsp;14, 2018;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.5in"><FONT STYLE="font-family: Times New Roman, Times, Serif"><B>(d)<FONT STYLE="font-size: 10pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;
</FONT></B></FONT>The description of the Registrant&rsquo;s Common Stock contained in the Registrant&rsquo;s registration statement
on Form 8-A filed with the SEC on April 29, 2016, including any amendments or reports filed for the purpose of updating such description;
and</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.5in"><FONT STYLE="font-family: Times New Roman, Times, Serif"><B>(e)<FONT STYLE="font-size: 10pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;
</FONT></B></FONT>All documents, reports and definitive proxy or information statements filed by the Registrant pursuant to Sections
13(a), 13(c), 14 and 15(d) of the Securities Exchange Act of 1934, as amended, (other than current reports furnished under Item
2.02 or Item 7.01 of Form 8-K and exhibits furnished on such form that relate to such items) on or after the date of this Registration
Statement and prior to the filing of a post-effective amendment to this Registration Statement that indicates that all securities
offered have been sold or that deregisters all securities then remaining unsold shall be deemed to be incorporated by reference
in this Registration Statement and to be part hereof from the date of filing of such documents. Any statement contained in a document
incorporated or deemed to be incorporated by reference herein shall be deemed to be modified or superseded for purposes of this
Registration Statement to the extent that a statement contained herein or in any subsequently filed document that also is deemed
to be incorporated by reference herein modifies or supersedes such statement. Any such statement so modified or superseded shall
not be deemed, except as so modified or superseded, to constitute a part of this Registration Statement.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.5in">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0"></TD><TD STYLE="width: 1in"><B>ITEM 8.</B></TD><TD><B>EXHIBITS</B>&nbsp;</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="border-collapse: collapse; width: 100%; font: 10pt Times New Roman, Times, Serif">
<TR STYLE="vertical-align: bottom">
    <TD NOWRAP STYLE="font: 10pt Times New Roman, Times, Serif; border-bottom: Black 1pt solid; text-align: left; vertical-align: top"><P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B>Exhibit</B></P> <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B>Number</B></P></TD><TD STYLE="font-size: 10pt; font-weight: bold; padding-bottom: 1pt; text-align: left; vertical-align: top">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; font-weight: bold; border-bottom: Black 1pt solid; text-align: left; vertical-align: bottom">Description</TD></TR>
<TR STYLE="vertical-align: bottom">
    <TD STYLE="width: 10%; font: 10pt Times New Roman, Times, Serif; text-align: left; vertical-align: top"><A HREF="http://www.sec.gov/Archives/edgar/data/1649989/000157104916015410/t1601379_ex3-1.htm" STYLE="-sec-extract: exhibit">4.1</A></TD><TD STYLE="width: 2%; font-size: 10pt; text-align: left; vertical-align: top">&nbsp;</TD>
    <TD STYLE="width: 88%; font-size: 10pt; text-align: left; vertical-align: top"><A HREF="http://www.sec.gov/Archives/edgar/data/1649989/000157104916015410/t1601379_ex3-1.htm" STYLE="-sec-extract: exhibit">Amended and Restated Certificate of Incorporation of Oncobiologics, Inc. (incorporated by reference to Exhibit 3.1 to the Registrant&rsquo;s current report on Form 8-K, filed with the SEC on May 19, 2016)</A></TD></TR>
<TR STYLE="vertical-align: bottom">
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left; vertical-align: top"><A HREF="http://www.sec.gov/Archives/edgar/data/1649989/000157104916015410/t1601379_ex3-2.htm" STYLE="-sec-extract: exhibit">4.2</A></TD><TD STYLE="font-size: 10pt; text-align: left; vertical-align: top">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left; vertical-align: top"><A HREF="http://www.sec.gov/Archives/edgar/data/1649989/000157104916015410/t1601379_ex3-2.htm" STYLE="-sec-extract: exhibit">Amended and Restated Bylaws of Oncobiologics, Inc. (incorporated by reference to Exhibit 3.2 to the Registrant&rsquo;s current report on Form 8-K, filed with the SEC on May 19, 2016)</A></TD></TR>
<TR STYLE="vertical-align: bottom">
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left; vertical-align: top"><A HREF="http://www.sec.gov/Archives/edgar/data/1649989/000157104916020211/t1602946_ex3-1.htm" STYLE="-sec-extract: exhibit">4.3</A></TD><TD STYLE="font-size: 10pt; text-align: left; vertical-align: top">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left; vertical-align: top"><A HREF="http://www.sec.gov/Archives/edgar/data/1649989/000157104916020211/t1602946_ex3-1.htm" STYLE="-sec-extract: exhibit">Amendment to the Amended and Restated Bylaws of Oncobiologics, Inc. (incorporated by reference to Exhibit 3.1 to the Registrant&rsquo;s current report on Form 8-K, filed with the SEC on November 29, 2016)</A></TD></TR>
<TR STYLE="vertical-align: bottom">
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left; vertical-align: top"><A HREF="http://www.sec.gov/Archives/edgar/data/1649989/000114420417047463/v474908_ex3-1.htm" STYLE="-sec-extract: exhibit">4.4</A></TD><TD STYLE="font-size: 10pt; text-align: left; vertical-align: top">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left; vertical-align: top"><A HREF="http://www.sec.gov/Archives/edgar/data/1649989/000114420417047463/v474908_ex3-1.htm" STYLE="-sec-extract: exhibit">Certificate of Designation of Series A Convertible Preferred Stock and of Series B Convertible Preferred Stock of Oncobiologics, Inc. (incorporated by reference to Exhibit 3.1 to the Registrant&rsquo;s current report on Form 8-K filed with the SEC on September 11, 2017)</A></TD></TR>
<TR STYLE="vertical-align: bottom">
    <TD STYLE="font-size: 10pt; text-align: left; vertical-align: top"><A HREF="tv484981_ex5-1.htm" STYLE="-sec-extract: exhibit">5.1</A></TD><TD STYLE="font-size: 10pt; text-align: left; vertical-align: top">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left; vertical-align: top"><A HREF="tv484981_ex5-1.htm" STYLE="-sec-extract: exhibit">Opinion of Cooley LLP</A></TD></TR>
<TR STYLE="vertical-align: bottom">
    <TD STYLE="font-size: 10pt; text-align: left; vertical-align: top"><A HREF="tv484981_ex23-1.htm" STYLE="-sec-extract: exhibit">23.1</A></TD><TD STYLE="font-size: 10pt; text-align: left; vertical-align: top">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left; vertical-align: top"><A HREF="tv484981_ex23-1.htm" STYLE="-sec-extract: exhibit">Consent of Independent Registered Public Accounting Firm.</A></TD></TR>
<TR STYLE="vertical-align: bottom">
    <TD STYLE="font-size: 10pt; text-align: left; vertical-align: top"><A HREF="tv484981_ex5-1.htm" STYLE="-sec-extract: exhibit">23.2</A></TD><TD STYLE="font-size: 10pt; text-align: left; vertical-align: top">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left; vertical-align: top"><A HREF="tv484981_ex5-1.htm" STYLE="-sec-extract: exhibit">Consent of Cooley LLP (included in Exhibit 5.1)</A></TD></TR>
<TR STYLE="vertical-align: bottom">
    <TD STYLE="font-size: 10pt; text-align: left; vertical-align: top"><A HREF="#powerofattorney" STYLE="-sec-extract: exhibit">24.1</A></TD><TD STYLE="font-size: 10pt; text-align: left; vertical-align: top">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left; vertical-align: top"><A HREF="#powerofattorney" STYLE="-sec-extract: exhibit">Power of Attorney (see signature page)</A></TD></TR>
<TR STYLE="vertical-align: bottom">
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left; vertical-align: top"><A HREF="http://www.sec.gov/Archives/edgar/data/1649989/000157104916010787/t1600032_ex10-3.htm" STYLE="-sec-extract: exhibit">99.1</A></TD><TD STYLE="font-size: 10pt; text-align: left; vertical-align: top">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left; vertical-align: top"><A HREF="http://www.sec.gov/Archives/edgar/data/1649989/000157104916010787/t1600032_ex10-3.htm" STYLE="-sec-extract: exhibit">2015 Equity Incentive Plan (incorporated by reference to Exhibit 10.3 to the Registrant&rsquo;s registration statement on Form S-1 (File No. 333-209011), filed with the SEC on January 15, 2016)</A></TD></TR>
<TR STYLE="vertical-align: bottom">
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left; vertical-align: top"><A HREF="http://www.sec.gov/Archives/edgar/data/1649989/000157104916010787/t1600032_ex10-4.htm" STYLE="-sec-extract: exhibit">99.2</A></TD><TD STYLE="font-size: 10pt; text-align: left; vertical-align: top">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left; vertical-align: top"><A HREF="http://www.sec.gov/Archives/edgar/data/1649989/000157104916010787/t1600032_ex10-4.htm" STYLE="-sec-extract: exhibit">Forms of agreements and award grant notices under 2015 Equity Incentive Plan (incorporated by reference to Exhibit 10.4 to the Registrant&rsquo;s registration statement on Form S-1 (File No. 333-209011), filed with the SEC on January 15, 2016)</A></TD></TR>
<TR STYLE="vertical-align: bottom">
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left; vertical-align: top"><A HREF="http://www.sec.gov/Archives/edgar/data/1649989/000157104916011706/t1603170_ex10-5.htm" STYLE="-sec-extract: exhibit">99.3</A></TD><TD STYLE="font-size: 10pt; text-align: left; vertical-align: top">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left; vertical-align: top"><A HREF="http://www.sec.gov/Archives/edgar/data/1649989/000157104916011706/t1603170_ex10-5.htm" STYLE="-sec-extract: exhibit">2016 Employee Stock Purchase Plan (incorporated by reference to Exhibit 10.5 to the Registrant&rsquo;s registration statement on Form S-1 (File No. 333-209011), filed with the SEC on February 12, 2016)</A></TD></TR>
</TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"></P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0"></TD><TD STYLE="width: 1in"><B>ITEM 9.</B></TD><TD><B>UNDERTAKINGS</B></TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0"></TD><TD STYLE="width: 0.5in"><FONT STYLE="font-family: Times New Roman, Times, Serif"><B>1.</B></FONT></TD><TD STYLE="text-align: justify">The undersigned registrant hereby undertakes:</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.5in"><FONT STYLE="font-family: Times New Roman, Times, Serif"><B>(a)<FONT STYLE="font-size: 10pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;
</FONT></B></FONT>To file, during any period in which offers or sales are being made, a post-effective amendment to this registration
statement:</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in; text-align: justify; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 1in">(i)<FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;
</FONT>To include any prospectus required by Section 10(a)(3) of the Securities Act;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 1in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 1in">(ii)<FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;
</FONT>To reflect in the prospectus any facts or events arising after the effective date of the registration statement (or the
most recent post-effective amendment thereof) which, individually or in the aggregate, represent a fundamental change in the information
set forth in the registration statement. Notwithstanding the foregoing, any increase or decrease in volume of securities offered
(if the total dollar value of securities offered would not exceed that which was registered) and any deviation from the low or
high end of the estimated maximum offering range may be reflected in the form of prospectus filed with the Commission pursuant
to Rule 424(b) if, in the aggregate, the changes in volume and price represent no more than a 20% change in the maximum aggregate
offering price set forth in the &ldquo;Calculation of Registration Fee&rdquo; table in the effective registration statement.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 1in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 1in">(iii)<FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;
</FONT>To include any material information with respect to the plan of distribution not previously disclosed in the registration
statement or any material change to such information in the registration statement;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 1in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in"><I>provided, however</I>, that paragraphs
(a)(i) and (a)(ii) do not apply if the information required to be included in a post-effective amendment by those paragraphs is
contained in reports filed with or furnished to the Commission by the registrant pursuant to section&nbsp;13 or section&nbsp;15(d)
of the Exchange Act that are incorporated by reference in the registration statement.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.5in"><FONT STYLE="font-family: Times New Roman, Times, Serif"><B>(b)<FONT STYLE="font-size: 10pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;
</FONT></B></FONT>That, for the purpose of determining any liability under the Securities Act, each such post-effective amendment
shall be deemed to be a new registration statement relating to the securities offered herein, and the offering of such securities
at that time shall be deemed to be the initial bona fide offering thereof.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.5in"><FONT STYLE="font-family: Times New Roman, Times, Serif"><B>(c)<FONT STYLE="font-size: 10pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;
</FONT></B></FONT>To remove from registration by means of a post-effective amendment any of the securities being registered which
remain unsold at the termination of the offering.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 1in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 1in"></P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 1in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 1in">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0"></TD><TD STYLE="width: 0.5in"><FONT STYLE="font-family: Times New Roman, Times, Serif"><B>2.</B></FONT></TD><TD STYLE="text-align: justify">The undersigned registrant hereby undertakes that, for purposes of determining any liability under
the Securities Act, each filing of the registrant&rsquo;s annual report pursuant to Section 13(a) or Section 15(d) of the Exchange
Act (and, where applicable, each filing of an employee benefit plan&rsquo;s annual report pursuant to section 15(d) of the Exchange
Act) that is incorporated by reference in the Registration Statement shall be deemed to be a new registration statement relating
to the securities offered herein, and the offering of such securities at that time shall be deemed to be the initial bona fide
offering thereof.</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0in">Insofar as indemnification
for liabilities arising under the Securities Act may be permitted to directors, officers and controlling persons of the registrant
pursuant to the foregoing provisions, or otherwise, the registrant has been advised that in the opinion of the Securities and
Exchange Commission such indemnification is against public policy as expressed in the Securities Act and is, therefore, unenforceable.
In the event that a claim for indemnification against such liabilities (other than the payment by the registrant of expenses incurred
or paid by a director, officer or controlling person of the registrant in the successful defense of any action, suit or proceeding)
is asserted by such director, officer or controlling person in connection with the securities being registered, the registrant
will, unless in the opinion of its counsel the matter has been settled by controlling precedent, submit to a court of appropriate
jurisdiction the question whether such indemnification by it is against public policy as expressed in the Securities Act and will
be governed by the final adjudication of such issue.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0in"></P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0in"></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center"><B>SIGNATURES</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in; text-align: center; text-indent: 0in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">Pursuant to the requirements of the Securities
Act of 1933, as amended, the Registrant certifies that it has reasonable grounds to believe that it meets all of the requirements
for filing on Form&nbsp;S-8 and has duly caused this Registration Statement to be signed on its behalf by the undersigned, thereunto
duly authorized, in Cranbury, New Jersey, on February 15, 2018.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="border-collapse: collapse; width: 100%">
<TR STYLE="vertical-align: bottom">
    <TD STYLE="font: small-caps bold 10pt Times New Roman, Times, Serif"><FONT STYLE="font-size: 10pt">&nbsp;</FONT></TD>
    <TD COLSPAN="3" STYLE="font: small-caps bold 10pt Times New Roman, Times, Serif; text-align: left"><FONT STYLE="font-size: 10pt">Oncobiologics, Inc.</FONT></TD></TR>
<TR STYLE="vertical-align: bottom">
    <TD><FONT STYLE="font-size: 10pt">&nbsp;</FONT></TD>
    <TD STYLE="text-align: left"><FONT STYLE="font-size: 10pt">&nbsp;</FONT></TD><TD><FONT STYLE="font-size: 10pt">&nbsp;</FONT></TD>
    <TD STYLE="text-align: left"><FONT STYLE="font-size: 10pt">&nbsp;</FONT></TD></TR>
<TR STYLE="vertical-align: bottom">
    <TD STYLE="width: 50%; font: 10pt Times New Roman, Times, Serif"><FONT STYLE="font-size: 10pt">&nbsp;</FONT></TD>
    <TD NOWRAP STYLE="width: 3%; font: 10pt Times New Roman, Times, Serif"><FONT STYLE="font-size: 10pt">By:</FONT></TD><TD STYLE="width: 1%; font: 10pt Times New Roman, Times, Serif"><FONT STYLE="font-size: 10pt">&nbsp;</FONT></TD>
    <TD STYLE="width: 46%; font: 10pt Times New Roman, Times, Serif; text-align: left; border-bottom: Black 1pt solid"><FONT STYLE="font-size: 10pt">/s/ Pankaj
    Mohan</FONT></TD></TR>
<TR STYLE="vertical-align: bottom">
    <TD STYLE="font: 10pt Times New Roman, Times, Serif"><FONT STYLE="font-size: 10pt">&nbsp;</FONT></TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif"><FONT STYLE="font-size: 10pt">&nbsp;</FONT></TD><TD STYLE="font: 10pt Times New Roman, Times, Serif"><FONT STYLE="font-size: 10pt">&nbsp;</FONT></TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left"><FONT STYLE="font-size: 10pt">Pankaj Mohan, Ph.D.</FONT></TD></TR>
<TR STYLE="vertical-align: bottom">
    <TD STYLE="font: italic 10pt Times New Roman, Times, Serif"><FONT STYLE="font-size: 10pt">&nbsp;</FONT></TD>
    <TD STYLE="font: italic 10pt Times New Roman, Times, Serif"><FONT STYLE="font-size: 10pt">&nbsp;</FONT></TD><TD STYLE="font: italic 10pt Times New Roman, Times, Serif"><FONT STYLE="font-size: 10pt">&nbsp;</FONT></TD>
    <TD STYLE="font: italic 10pt Times New Roman, Times, Serif; text-align: left"><FONT STYLE="font-size: 10pt">Chairman, President
    and Chief Executive Officer</FONT></TD></TR>
</TABLE>


<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; text-indent: 3.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center"><B><A NAME="powerofattorney"></A>POWER OF ATTORNEY</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.5in">KNOW ALL BY THESE PRESENTS,
that each person whose signature appears below hereby constitutes and appoints Pankaj Mohan, Ph.D. and Lawrence A. Kenyon, and
each of them, his or her true and lawful attorney-in-fact and agent, with full power of substitution and resubstitution, for him
or her and in his or her name, place and stead, in any and all capacities, to sign any and all amendments (including post-effective
amendments) to this Registration Statement, and to file the same, with all exhibits thereto, and other documents in connection
therewith, with the Securities and Exchange Commission, granting unto said attorneys-in-fact and agents, and each of them, full
power and authority to do and perform each and every act and thing requisite and necessary to be done in connection therewith,
as fully to all intents and purposes as he or she might or could do in person, hereby ratifying and confirming all that said attorneys-in-fact
and agents, or each of them, or their or his or her substitutes or substitute, may lawfully do or cause to be done by virtue hereof.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 6pt; margin-left: 36pt; text-indent: 0pt; text-align: justify">Pursuant
to the requirements of the Securities Act of 1933, as amended, this Registration Statement has been signed by the following persons
in the capacities and on the dates indicated.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="border-collapse: collapse; width: 100%; font: 10pt Times New Roman, Times, Serif; text-decoration: none">
<TR STYLE="vertical-align: bottom; text-decoration: none">
    <TD STYLE="width: 32%; font: bold 10pt Times New Roman, Times, Serif; text-align: center; border-bottom: Black 1pt solid; text-decoration: none">Signature</TD><TD STYLE="width: 2%; font: bold 10pt Times New Roman, Times, Serif; text-decoration: none">&nbsp;</TD>
    <TD STYLE="width: 32%; font: bold 10pt Times New Roman, Times, Serif; text-align: center; border-bottom: Black 1pt solid; text-decoration: none">Title</TD><TD STYLE="width: 2%; font: bold 10pt Times New Roman, Times, Serif; text-decoration: none">&nbsp;</TD>
    <TD STYLE="width: 32%; font: bold 10pt Times New Roman, Times, Serif; text-align: center; border-bottom: Black 1pt solid; text-decoration: none">Date</TD></TR>
<TR STYLE="vertical-align: bottom; text-decoration: none">
    <TD STYLE="font: bold 10pt Times New Roman, Times, Serif; text-align: center; text-decoration: none">&nbsp;</TD><TD STYLE="font: bold 10pt Times New Roman, Times, Serif; text-decoration: none">&nbsp;</TD>
    <TD STYLE="font: bold 10pt Times New Roman, Times, Serif; text-align: center; text-decoration: none">&nbsp;</TD><TD STYLE="font: bold 10pt Times New Roman, Times, Serif; text-decoration: none">&nbsp;</TD>
    <TD STYLE="font: bold 10pt Times New Roman, Times, Serif; text-align: center; text-decoration: none">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; text-decoration: none">
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-decoration: none; text-align: center; border-bottom: Black 1pt solid">/s/Pankaj
    Mohan, Ph.D.</TD><TD STYLE="font-size: 10pt; text-decoration: none">&nbsp;</TD>
    <TD NOWRAP STYLE="font-size: 10pt; text-align: center; text-decoration: none">Chairman, President and Chief Executive Officer </TD><TD STYLE="font-size: 10pt; text-decoration: none">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-decoration: none; text-align: center">February 15, 2018</TD></TR>
<TR STYLE="vertical-align: bottom; text-decoration: none">
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-decoration: none; text-align: center">Pankaj Mohan, Ph.D.</TD><TD STYLE="font-size: 10pt; text-decoration: none">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: center; text-decoration: none">(Principal Executive Officer)</TD><TD STYLE="font-size: 10pt; text-decoration: none">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-decoration: none; text-align: center">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; text-decoration: none">
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-decoration: none; text-align: center">&nbsp;</TD><TD STYLE="font-size: 10pt; text-decoration: none">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: center; text-decoration: none">&nbsp;</TD><TD STYLE="font-size: 10pt; text-decoration: none">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-decoration: none; text-align: center">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; text-decoration: none">
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-decoration: none; text-align: center; border-bottom: Black 1pt solid">/s/
    Lawrence A. Kenyon</TD><TD STYLE="font-size: 10pt; text-decoration: none">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: center; text-decoration: none">Chief Financial Officer</TD><TD STYLE="font-size: 10pt; text-decoration: none">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-decoration: none; text-align: center">February 15, 2018</TD></TR>
<TR STYLE="vertical-align: bottom; text-decoration: none">
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-decoration: none; text-align: center">Lawrence A. Kenyon</TD><TD STYLE="font-size: 10pt; text-decoration: none">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: center; text-decoration: none">(Principal Accounting and
    Financial Officer)</TD><TD STYLE="font-size: 10pt; text-decoration: none">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-decoration: none; text-align: center">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; text-decoration: none">
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-decoration: none; text-align: center">&nbsp;</TD><TD STYLE="font-size: 10pt; text-decoration: none">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: center; text-decoration: none">&nbsp;</TD><TD STYLE="font-size: 10pt; text-decoration: none">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-decoration: none; text-align: center">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; text-decoration: none">
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-decoration: none; text-align: center; border-bottom: Black 1pt solid">/s/
    Claudio Albrecht</TD><TD STYLE="font-size: 10pt; text-decoration: none">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: center; text-decoration: none">Director</TD><TD STYLE="font-size: 10pt; text-decoration: none">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-decoration: none; text-align: center">February 15, 2018</TD></TR>
<TR STYLE="vertical-align: bottom; text-decoration: none">
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-decoration: none; text-align: center">Claudio Albrecht</TD><TD STYLE="font-size: 10pt; text-decoration: none">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: center; text-decoration: none">&nbsp;</TD><TD STYLE="font-size: 10pt; text-decoration: none">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-decoration: none; text-align: center">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; text-decoration: none">
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-decoration: none; text-align: center">&nbsp;</TD><TD STYLE="font-size: 10pt; text-decoration: none">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: center; text-decoration: none">&nbsp;</TD><TD STYLE="font-size: 10pt; text-decoration: none">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-decoration: none; text-align: center">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; text-decoration: none">
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-decoration: none; text-align: center; border-bottom: Black 1pt solid">/s/
    Scott Canute</TD><TD STYLE="font-size: 10pt; text-decoration: none">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: center; text-decoration: none">Director</TD><TD STYLE="font-size: 10pt; text-decoration: none">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-decoration: none; text-align: center">February 15, 2018</TD></TR>
<TR STYLE="vertical-align: bottom; text-decoration: none">
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-decoration: none; text-align: center">Scott Canute</TD><TD STYLE="font-size: 10pt; text-decoration: none">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: center; text-decoration: none">&nbsp;</TD><TD STYLE="font-size: 10pt; text-decoration: none">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-decoration: none; text-align: center">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; text-decoration: none">
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-decoration: none; text-align: center">&nbsp;</TD><TD STYLE="font-size: 10pt; text-decoration: none">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: center; text-decoration: none">&nbsp;</TD><TD STYLE="font-size: 10pt; text-decoration: none">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-decoration: none; text-align: center">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; text-decoration: none">
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-decoration: none; text-align: center; border-bottom: Black 1pt solid">/s/
    Yezan Haddadin</TD><TD STYLE="font-size: 10pt; text-decoration: none">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: center; text-decoration: none">Director</TD><TD STYLE="font-size: 10pt; text-decoration: none">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-decoration: none; text-align: center">February 15, 2018</TD></TR>
<TR STYLE="vertical-align: bottom; text-decoration: none">
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-decoration: none; text-align: center">Yezan Haddadin</TD><TD STYLE="font-size: 10pt; text-decoration: none">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: center; text-decoration: none">&nbsp;</TD><TD STYLE="font-size: 10pt; text-decoration: none">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-decoration: none; text-align: center">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; text-decoration: none">
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-decoration: none; text-align: center">&nbsp;</TD><TD STYLE="font-size: 10pt; text-decoration: none">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: center; text-decoration: none">&nbsp;</TD><TD STYLE="font-size: 10pt; text-decoration: none">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-decoration: none; text-align: center">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; text-decoration: none">
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-decoration: none; text-align: center; border-bottom: Black 1pt solid">/s/
    Kurt J. Hilzinger</TD><TD STYLE="font-size: 10pt; text-decoration: none">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: center; text-decoration: none">Director</TD><TD STYLE="font-size: 10pt; text-decoration: none">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-decoration: none; text-align: center">February 15, 2018</TD></TR>
<TR STYLE="vertical-align: bottom; text-decoration: none">
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-decoration: none; text-align: center">Kurt J. Hilzinger</TD><TD STYLE="font-size: 10pt; text-decoration: none">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: center; text-decoration: none">&nbsp;</TD><TD STYLE="font-size: 10pt; text-decoration: none">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-decoration: none; text-align: center">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; text-decoration: none">
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-decoration: none; text-align: center">&nbsp;</TD><TD STYLE="font-size: 10pt; text-decoration: none">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: center; text-decoration: none">&nbsp;</TD><TD STYLE="font-size: 10pt; text-decoration: none">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-decoration: none; text-align: center">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; text-decoration: none">
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-decoration: none; text-align: center; border-bottom: Black 1pt solid">/s/
    Faisal Sukhtian</TD><TD STYLE="font-size: 10pt; text-decoration: none">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: center; text-decoration: none">Director</TD><TD STYLE="font-size: 10pt; text-decoration: none">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-decoration: none; text-align: center">February 15, 2018</TD></TR>
<TR STYLE="vertical-align: bottom; text-decoration: none">
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-decoration: none; text-align: center">Faisal Sukhtian</TD><TD STYLE="font-size: 10pt; text-decoration: none">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: center; text-decoration: none">&nbsp;</TD><TD STYLE="font-size: 10pt; text-decoration: none">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-decoration: none; text-align: center">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; text-decoration: none">
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-decoration: none; text-align: center">&nbsp;</TD><TD STYLE="font-size: 10pt; text-decoration: none">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: center; text-decoration: none">&nbsp;</TD><TD STYLE="font-size: 10pt; text-decoration: none">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-decoration: none; text-align: center">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; text-decoration: none">
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-decoration: none; text-align: center; border-bottom: Black 1pt solid">/s/
    Joe Thomas</TD><TD STYLE="font-size: 10pt; text-decoration: none">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: center; text-decoration: none">Director</TD><TD STYLE="font-size: 10pt; text-decoration: none">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-decoration: none; text-align: center">February 15, 2018</TD></TR>
<TR STYLE="vertical-align: bottom; text-decoration: none">
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-decoration: none; text-align: center">Joe Thomas</TD><TD STYLE="font-size: 10pt; text-decoration: none">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: center; text-decoration: none">&nbsp;</TD><TD STYLE="font-size: 10pt; text-decoration: none">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-decoration: none; text-align: center">&nbsp;</TD></TR>
</TABLE>




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[{"type": "S-8", "sequence": "1", "filename": "tv484981_s8.htm", "description": "FORM S-8", "secsgml_size_bytes": 67271}]
{"company-data": {"conformed-name": "Oncobiologics, Inc.", "cik": "0001649989", "assigned-sic": "2836", "irs-number": "383982704", "state-of-incorporation": "DE", "fiscal-year-end": "0930"}, "filing-values": {"form-type": "S-8", "act": "33", "file-number": "333-223064", "film-number": "18618782"}, "business-address": {"street1": "7 CLARKE DRIVE", "city": "CRANBURY", "state": "NJ", "zip": "08512", "phone": "6096193990"}, "mail-address": {"street1": "7 CLARKE DRIVE", "city": "CRANBURY", "state": "NJ", "zip": "08512"}}
As filed with the Securities
and Exchange Commission on February 15, 2018
Registration No. 333-
UNITED STATES
SECURITIES AND EXCHANGE
COMMISSION
Washington, D.C. 20549
FORM S-8
REGISTRATION STATEMENT
UNDER
THE SECURITIES ACT OF 1933
Oncobiologics, Inc.
(Exact name of Registrant
as specified in its charter)
Delaware
38-3982704
(State or other jurisdiction of Incorporation or organization)
(I.R.S. Employer Identification No.)
7 Clarke Drive
Cranbury, New Jersey 08512
(Address of principal executive offices)
(Zip code)
2015 Equity Incentive Plan
2016 Employee Stock Purchase Plan
_____________________________________
(Full title of the plan)
Pankaj Mohan, Ph.D.
Chairman, President and Chief Executive
Officer
Oncobiologics, Inc.
7 Clarke Drive
Cranbury, New Jersey 08512
(609) 619-3990
(Name and address of agent for service)
(Telephone number, including area code, of agent for service)
Copies to:
Yvan-Claude Pierre
Marianne C. Sarrazin
Cooley LLP
1114 Avenue of the Americas
New York, New York 10036
(212) 479-6000
Lawrence A. Kenyon
Chief Financial Officer
Oncobiologics, Inc.
7 Clarke Drive
Cranbury, New Jersey 08512
(609) 619-3990
Indicate by check mark whether the registrant is a large accelerated
filer, an accelerated filer, a non-accelerated filer, a smaller reporting company, or an emerging growth company. See the definitions
of "large accelerated filer," "accelerated filer," "smaller reporting company," and "emerging
growth company" in Rule 12b-2 of the Exchange Act.
Large accelerated filer
¨
Accelerated filer
¨
Non-accelerated filer
¨
(Do not check if a smaller reporting company)
Smaller reporting company
x
Emerging growth company
x
CALCULATION OF REGISTRATION FEE
Title of Securities
to be Registered
Amount to be
Registered(1)
Proposed
Maximum
Offering
Price per
Share(6)
Proposed
Maximum
Aggregate
Offering
Price(6)
Amount
of
Registration
Fee
Common Stock, par value $0.01 per share, reserved for issuance pursuant to the 2015 Equity Incentive Plan
765,921
(2)(3)
$
1.20
$
919,105.20
$
114.43
Common Stock, par value $0.01 per share, reserved for issuance pursuant to the 2016 Employee Stock Purchase Plan
255,307
(4)(5)
$
1.20
$
306,368.40
$
38.14
Total
1,021,228
$
1.20
$
1,225,473.60
$
152.57
(1)
Pursuant to Rule 416(a) promulgated under the Securities Act of 1933, as amended (the "
Securities Act
"), this Registration Statement shall also cover any additional shares of Registrant's common stock, par value $0.01 (the "
Common Stock
"), that become issuable under the 2015 Equity Incentive Plan ("
2015 EIP
") or the 2016 Employee Stock Purchase Plan ("
ESPP
"), set forth herein by reason of any stock dividend, stock split, recapitalization or other similar transaction effected that results in an increase to the number of outstanding shares of Common Stock.
(2)
Represents additional shares of Common Stock reserved for future issuance under the 2015 EIP by reason of the automatic increase provision of the 2015 EIP.
(3)
The number of shares of Common Stock reserved for issuance under the 2015 EIP automatically increases on January 1st each year, starting on January 1, 2017 and continuing through January 1, 2026, by the lesser of (A) 3% of the total number of shares of Common Stock outstanding on December 31st of the immediately preceding calendar year, (B) 1,760,000 and (C) a number determined by the Registrant's board of directors.
(4)
Represents additional shares of Common Stock reserved for future issuance under the ESPP by reason of the automatic increase provision of the ESPP.
(5)
The number of shares of Common Stock reserved for issuance under the ESPP automatically increases on January 1st each year, starting on January 1, 2017 and continuing through January 1, 2026, by the lesser of (A) 1% of the total number of shares of Common Stock outstanding on December 31st of the immediately preceding calendar year and (B) a number determined by the Registrant's board of directors.
(6)
Estimated in accordance with Rule 457(h) under the Securities
    Act solely for the purpose of calculating the registration fee on the basis of $1.20, the average of the high and low
    prices of the Registrant's Common Stock as reported on the Nasdaq Global Market on February 13, 2018.
EXPLANATORY
NOTE
Oncobiologics,
Inc. (the "
Registrant
") is filing this Registration Statement on Form S-8 for the purpose of registering
an additional 765,921 shares of its Common Stock issuable to eligible persons under the 2015 EIP and an additional 255,307 shares
of its Common Stock issuable to eligible persons under the ESPP, in each case which Common Stock is in addition to the shares of
Common Stock registered on the Registrant's Form S-8s filed on May 13, 2016 (File No. 333-211362) and on February
15, 2017 (File No. 333-216,081) (the "
Prior Form S-8s
").
PART II
ITEM 3.
INCORPORATION OF CERTAIN DOCUMENTS BY REFERENCE
Pursuant to General Instruction
E to Form S-8, the contents of the Prior Form S-8s filed by the Registrant are incorporated by reference herein. In addition, the
following documents filed by the Registrant with the Securities and Exchange Commission ("
SEC
") are incorporated
by reference into this Registration Statement:
(a)
The Registrant's latest annual report on Form 10-K, filed with the SEC on December 29, 2017, as amended
January 29, 2018;
(b)
The Registrant's quarterly report on Form 10-Q, filed with the SEC on February 14, 2018;
(c)
The Registrant's current reports on Form 8-K, filed with the SEC on October 6, 2017, October 31,
2017, January 4, 2018, February 7, 2018, February 9, 2018, and February 14, 2018;
(d)
The description of the Registrant's Common Stock contained in the Registrant's registration statement
on Form 8-A filed with the SEC on April 29, 2016, including any amendments or reports filed for the purpose of updating such description;
and
(e)
All documents, reports and definitive proxy or information statements filed by the Registrant pursuant to Sections
13(a), 13(c), 14 and 15(d) of the Securities Exchange Act of 1934, as amended, (other than current reports furnished under Item
2.02 or Item 7.01 of Form 8-K and exhibits furnished on such form that relate to such items) on or after the date of this Registration
Statement and prior to the filing of a post-effective amendment to this Registration Statement that indicates that all securities
offered have been sold or that deregisters all securities then remaining unsold shall be deemed to be incorporated by reference
in this Registration Statement and to be part hereof from the date of filing of such documents. Any statement contained in a document
incorporated or deemed to be incorporated by reference herein shall be deemed to be modified or superseded for purposes of this
Registration Statement to the extent that a statement contained herein or in any subsequently filed document that also is deemed
to be incorporated by reference herein modifies or supersedes such statement. Any such statement so modified or superseded shall
not be deemed, except as so modified or superseded, to constitute a part of this Registration Statement.
ITEM 8.
EXHIBITS
Exhibit
Number
Description
4.1
Amended and Restated Certificate of Incorporation of Oncobiologics, Inc. (incorporated by reference to Exhibit 3.1 to the Registrant's current report on Form 8-K, filed with the SEC on May 19, 2016)
4.2
Amended and Restated Bylaws of Oncobiologics, Inc. (incorporated by reference to Exhibit 3.2 to the Registrant's current report on Form 8-K, filed with the SEC on May 19, 2016)
4.3
Amendment to the Amended and Restated Bylaws of Oncobiologics, Inc. (incorporated by reference to Exhibit 3.1 to the Registrant's current report on Form 8-K, filed with the SEC on November 29, 2016)
4.4
Certificate of Designation of Series A Convertible Preferred Stock and of Series B Convertible Preferred Stock of Oncobiologics, Inc. (incorporated by reference to Exhibit 3.1 to the Registrant's current report on Form 8-K filed with the SEC on September 11, 2017)
5.1
Opinion of Cooley LLP
23.1
Consent of Independent Registered Public Accounting Firm.
23.2
Consent of Cooley LLP (included in Exhibit 5.1)
24.1
Power of Attorney (see signature page)
99.1
2015 Equity Incentive Plan (incorporated by reference to Exhibit 10.3 to the Registrant's registration statement on Form S-1 (File No. 333-209011), filed with the SEC on January 15, 2016)
99.2
Forms of agreements and award grant notices under 2015 Equity Incentive Plan (incorporated by reference to Exhibit 10.4 to the Registrant's registration statement on Form S-1 (File No. 333-209011), filed with the SEC on January 15, 2016)
99.3
2016 Employee Stock Purchase Plan (incorporated by reference to Exhibit 10.5 to the Registrant's registration statement on Form S-1 (File No. 333-209011), filed with the SEC on February 12, 2016)
ITEM 9.
UNDERTAKINGS
1.
The undersigned registrant hereby undertakes:
(a)
To file, during any period in which offers or sales are being made, a post-effective amendment to this registration
statement:
(i)
To include any prospectus required by Section 10(a)(3) of the Securities Act;
(ii)
To reflect in the prospectus any facts or events arising after the effective date of the registration statement (or the
most recent post-effective amendment thereof) which, individually or in the aggregate, represent a fundamental change in the information
set forth in the registration statement. Notwithstanding the foregoing, any increase or decrease in volume of securities offered
(if the total dollar value of securities offered would not exceed that which was registered) and any deviation from the low or
high end of the estimated maximum offering range may be reflected in the form of prospectus filed with the Commission pursuant
to Rule 424(b) if, in the aggregate, the changes in volume and price represent no more than a 20% change in the maximum aggregate
offering price set forth in the "Calculation of Registration Fee" table in the effective registration statement.
(iii)
To include any material information with respect to the plan of distribution not previously disclosed in the registration
statement or any material change to such information in the registration statement;
provided, however
, that paragraphs
(a)(i) and (a)(ii) do not apply if the information required to be included in a post-effective amendment by those paragraphs is
contained in reports filed with or furnished to the Commission by the registrant pursuant to section 13 or section 15(d)
of the Exchange Act that are incorporated by reference in the registration statement.
(b)
That, for the purpose of determining any liability under the Securities Act, each such post-effective amendment
shall be deemed to be a new registration statement relating to the securities offered herein, and the offering of such securities
at that time shall be deemed to be the initial bona fide offering thereof.
(c)
To remove from registration by means of a post-effective amendment any of the securities being registered which
remain unsold at the termination of the offering.
2.
The undersigned registrant hereby undertakes that, for purposes of determining any liability under
the Securities Act, each filing of the registrant's annual report pursuant to Section 13(a) or Section 15(d) of the Exchange
Act (and, where applicable, each filing of an employee benefit plan's annual report pursuant to section 15(d) of the Exchange
Act) that is incorporated by reference in the Registration Statement shall be deemed to be a new registration statement relating
to the securities offered herein, and the offering of such securities at that time shall be deemed to be the initial bona fide
offering thereof.
Insofar as indemnification
for liabilities arising under the Securities Act may be permitted to directors, officers and controlling persons of the registrant
pursuant to the foregoing provisions, or otherwise, the registrant has been advised that in the opinion of the Securities and
Exchange Commission such indemnification is against public policy as expressed in the Securities Act and is, therefore, unenforceable.
In the event that a claim for indemnification against such liabilities (other than the payment by the registrant of expenses incurred
or paid by a director, officer or controlling person of the registrant in the successful defense of any action, suit or proceeding)
is asserted by such director, officer or controlling person in connection with the securities being registered, the registrant
will, unless in the opinion of its counsel the matter has been settled by controlling precedent, submit to a court of appropriate
jurisdiction the question whether such indemnification by it is against public policy as expressed in the Securities Act and will
be governed by the final adjudication of such issue.
SIGNATURES
Pursuant to the requirements of the Securities
Act of 1933, as amended, the Registrant certifies that it has reasonable grounds to believe that it meets all of the requirements
for filing on Form S-8 and has duly caused this Registration Statement to be signed on its behalf by the undersigned, thereunto
duly authorized, in Cranbury, New Jersey, on February 15, 2018.
Oncobiologics, Inc.
By:
/s/ Pankaj
    Mohan
Pankaj Mohan, Ph.D.
Chairman, President
    and Chief Executive Officer
POWER OF ATTORNEY
KNOW ALL BY THESE PRESENTS,
that each person whose signature appears below hereby constitutes and appoints Pankaj Mohan, Ph.D. and Lawrence A. Kenyon, and
each of them, his or her true and lawful attorney-in-fact and agent, with full power of substitution and resubstitution, for him
or her and in his or her name, place and stead, in any and all capacities, to sign any and all amendments (including post-effective
amendments) to this Registration Statement, and to file the same, with all exhibits thereto, and other documents in connection
therewith, with the Securities and Exchange Commission, granting unto said attorneys-in-fact and agents, and each of them, full
power and authority to do and perform each and every act and thing requisite and necessary to be done in connection therewith,
as fully to all intents and purposes as he or she might or could do in person, hereby ratifying and confirming all that said attorneys-in-fact
and agents, or each of them, or their or his or her substitutes or substitute, may lawfully do or cause to be done by virtue hereof.
Pursuant
to the requirements of the Securities Act of 1933, as amended, this Registration Statement has been signed by the following persons
in the capacities and on the dates indicated.
Signature
Title
Date
/s/Pankaj
    Mohan, Ph.D.
Chairman, President and Chief Executive Officer
February 15, 2018
Pankaj Mohan, Ph.D.
(Principal Executive Officer)
/s/
    Lawrence A. Kenyon
Chief Financial Officer
February 15, 2018
Lawrence A. Kenyon
(Principal Accounting and
    Financial Officer)
/s/
    Claudio Albrecht
Director
February 15, 2018
Claudio Albrecht
/s/
    Scott Canute
Director
February 15, 2018
Scott Canute
/s/
    Yezan Haddadin
Director
February 15, 2018
Yezan Haddadin
/s/
    Kurt J. Hilzinger
Director
February 15, 2018
Kurt J. Hilzinger
/s/
    Faisal Sukhtian
Director
February 15, 2018
Faisal Sukhtian
/s/
    Joe Thomas
Director
February 15, 2018
Joe Thomas