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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>As filed with the Securities and Exchange Commission
on November 15, 2024</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>&nbsp;</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: right"><B>Registration No. 333- </B></P>

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    <TD STYLE="width: 100%; border-bottom: black 2.25pt double; font-size: 10pt">&nbsp;</TD></TR>
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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: 12pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>UNITED STATES</B></P>

<P STYLE="font: 12pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>SECURITIES AND EXCHANGE COMMISSION</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>WASHINGTON, D.C. 20549</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">____________</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: 12pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>FORM S-8</B></P>

<P STYLE="font: 12pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>REGISTRATION STATEMENT</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B><I>UNDER</I></B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B><I>THE SECURITIES ACT OF 1933</I></B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">____________</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: 18pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>Aethlon Medical, Inc.</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">(Exact name of registrant as specified in its charter)</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">____________</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
  <TR STYLE="vertical-align: bottom">
    <TD STYLE="width: 34%; text-align: center"><B>Nevada</B></TD>
    <TD STYLE="width: 33%; text-align: center">&nbsp;</TD>
    <TD STYLE="width: 33%; text-align: center"><B>13-3632859</B></TD></TR>
  <TR STYLE="vertical-align: top">
    <TD STYLE="text-align: center">(State or other jurisdiction of incorporation)</TD>
    <TD STYLE="text-align: center">&nbsp;</TD>
    <TD STYLE="text-align: center">(I.R.S. Employer Identification No.)</TD></TR>
  </TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>&nbsp;</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>11555 Sorrento Valley Road, Suite 203</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>San Diego, California 92121</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">(Address of principal executive offices) (Zip Code)</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">____________</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>Aethlon Medical, Inc. 2020 Equity Incentive
Plan</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">(Full title of the plan)</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">____________</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>James B. Frakes</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>Chief Executive Officer and Chief Financial
Officer</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>Aethlon Medical, Inc.</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>11555 Sorrento Valley Road, Suite 203</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>San Diego, California 92121</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>(619) 941-0360</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">(Name, address, and telephone number, including
area code, of agent for service)</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">____________</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><I>Copies to</I>:</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>Dennis J. Doucette, Esq.</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>Procopio, Cory, Hargreaves &amp; Savitch LLP</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>12544 High Bluff Drive, Suite 400</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>San Diego, CA 92130</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>(858) 720-6300</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>&nbsp;</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">Indicate by check mark whether the registrant
is a large accelerated filer, an accelerated filer, a non-accelerated filer, a smaller reporting company or an emerging growth company.
See the definitions of &ldquo;large accelerated filer,&rdquo; &ldquo;accelerated filer,&rdquo; &ldquo;smaller reporting company,&rdquo;
and &ldquo;emerging growth company&rdquo; in Rule 12b-2 of the Exchange Act.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

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  <TR STYLE="vertical-align: top">
    <TD STYLE="width: 25%">Large accelerated Filer</TD>
    <TD STYLE="width: 25%"><B>&#9744;</B></TD>
    <TD STYLE="width: 25%">Accelerated Filer</TD>
    <TD STYLE="width: 25%"><B>&#9744;</B></TD></TR>
  <TR STYLE="vertical-align: top">
    <TD>Non-accelerated Filer</TD>
    <TD><FONT STYLE="font-size: 10pt">&#9746;</FONT></TD>
    <TD>Smaller reporting company</TD>
    <TD><FONT STYLE="font-size: 10pt">&#9746;</FONT></TD></TR>
  <TR>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: top">Emerging Growth Company</TD>
    <TD STYLE="vertical-align: top"><B>&#9744;</B></TD></TR>
  </TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">If an emerging growth company, indicate by check
mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting
standards provided pursuant to Section 7(a)(2)(B) of the Securities Act <B>&#9744;</B></P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"></P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 1in; text-align: center; text-indent: -1in"><B>REGISTRATION OF ADDITIONAL
SHARES PURSUANT TO GENERAL INSTRUCTION E</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">Pursuant to General Instruction E of Form S-8,
Aethlon Medical, Inc. (the &ldquo;Company&rdquo;) is filing this Registration Statement on Form S-8 (this &ldquo;Registration Statement&rdquo;)
to register an additional 3,000,000 shares of Company common stock, par value $0.001 per share (&ldquo;Common Stock&rdquo;), for issuance
under the Company&rsquo;s 2020 Equity Incentive Plan (the &ldquo;Original Plan&rdquo;), as amended on September 15, 2022 (the &ldquo;First
Amendment&rdquo;) and September 27, 2024 (the &ldquo;Second Amendment,&rdquo; and together with the Original Plan and the First Amendment,
the &ldquo;2020 Plan&rdquo;). Such additional shares of Common Stock were added to the 2020 Plan pursuant to the Second Amendment and
are in addition to the 364,256 shares of Common Stock (as adjusted for the Reverse Stock Split, as defined below) issuable pursuant to
the 2020 Plan registered on the Company&rsquo;s Registration Statements on Form S-8 filed with the Securities and Exchange Commission
(the &ldquo;Commission&rdquo;) on September 15, 2020 (Commission File No. <A HREF="https://www.sec.gov/Archives/edgar/data/882291/000168316820003133/aethlon_s8.htm">333-248820</A>)
and September 19, 2022 (Commission File No. <A HREF="https://www.sec.gov/Archives/edgar/data/882291/000168316822006483/aethlon_s8.htm">333-267504</A>),
the contents of which are hereby incorporated by reference into this Registration Statement, except to the extent supplemented, amended
or superseded by the information set forth in this Registration Statement or by any subsequently filed document.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">On October 4, 2023, the Company effected a one-for-ten
reverse stock split of the Company&rsquo;s issued and outstanding shares of Common Stock (the &ldquo;Reverse Stock Split&rdquo;). As a
result of the Reverse Stock Split, every ten shares of Common Stock issued and outstanding as of 5:00 p.m. Eastern Time on October 4,
2023 were combined into one share of Common Stock. The number of shares issuable pursuant to 2020 Plan were also adjusted proportionally
as a result of the Reverse Stock Split.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"></P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 1in; text-align: center; text-indent: -1in"><B>PART II </B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>INFORMATION REQUIRED IN REGISTRATION STATEMENT</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><B>Item 3. Incorporation of Documents by Reference.
</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">The following documents, which have been filed
by the Company with the Commission pursuant to the Securities Act of 1933, as amended, and the Securities Exchange Act of 1934, as amended
(the &ldquo;Exchange Act&rdquo;), are incorporated herein by reference:</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; width: 100%"><TR STYLE="vertical-align: top">
<TD STYLE="text-align: justify; width: 20pt"></TD><TD STYLE="width: 20pt; text-align: justify"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD STYLE="text-align: justify">The Company&rsquo;s <A HREF="https://www.sec.gov/ix?doc=/Archives/edgar/data/0000882291/000168316824004530/aethlon_i10k-033124.htm">Annual
Report on Form 10-K</A> for the fiscal year ended March 31, 2024, filed with the Commission on June 27, 2024, and <A HREF="https://www.sec.gov/Archives/edgar/data/882291/000168316824005774/aethlon_i10ka1-033124.htm">Amendment
No. 1</A> to the Company&rsquo;s Annual Report on Form 10-K, filed with the Commission on August 15, 2024;</TD>
</TR>
<TR STYLE="vertical-align: top">
<TD STYLE="text-align: justify; width: 20pt"></TD><TD STYLE="width: 20pt; text-align: justify">&nbsp;</TD><TD STYLE="text-align: justify">&nbsp;</TD>
</TR>
<TR STYLE="vertical-align: top">
<TD STYLE="text-align: justify; width: 20pt"></TD><TD STYLE="width: 20pt; text-align: justify"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD STYLE="text-align: justify">The Company&rsquo;s <A HREF="https://www.sec.gov/ix?doc=/Archives/edgar/data/0000882291/000168316824005708/aethlon_i10q-063024.htm">Quarterly
Report on Form 10-Q</A> for the quarter ended June 30, 2024, filed with the Commission on August 14, 2024;</TD>
</TR>
<TR STYLE="vertical-align: top">
<TD STYLE="text-align: justify; width: 20pt"></TD><TD STYLE="width: 20pt; text-align: justify">&nbsp;</TD><TD STYLE="text-align: justify">&nbsp;</TD>
</TR><TR STYLE="vertical-align: top">
<TD STYLE="text-align: justify">&nbsp;</TD><TD STYLE="text-align: justify"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD STYLE="text-align: justify">The Company&rsquo;s <A HREF="http://www.sec.gov/Archives/edgar/data/882291/000168316824007984/aethlon_i10q-093024.htm" STYLE="-sec-extract: exhibit">Quarterly
Report on Form 10-Q</A> for the quarter ended September 30, 2024, filed with the Commission on November 13, 2024;</TD></TR>
     <TR STYLE="vertical-align: top">
<TD STYLE="text-align: justify">&nbsp;</TD><TD STYLE="text-align: justify">&nbsp;</TD><TD STYLE="text-align: justify">&nbsp;</TD></TR>

<TR STYLE="vertical-align: top">
<TD STYLE="text-align: justify; width: 20pt"></TD><TD STYLE="width: 20pt; text-align: justify"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD STYLE="text-align: justify">The Company&rsquo;s Current Reports on Form 8-K, filed with the
Commission on <A HREF="https://www.sec.gov/ix?doc=/Archives/edgar/data/0000882291/000168316824002672/aethlon_8k.htm">April 25, 2024</A>,
<A HREF="https://www.sec.gov/ix?doc=/Archives/edgar/data/0000882291/000168316824003191/aethlon_8k.htm">May 10, 2024</A>, <A HREF="https://www.sec.gov/ix?doc=/Archives/edgar/data/0000882291/000168316824003612/aethlon_8k.htm">May
17, 2024</A>, <A HREF="https://www.sec.gov/ix?doc=/Archives/edgar/data/0000882291/000168316824003812/aethlon_8k.htm">May 24, 2024</A>,
<A HREF="https://www.sec.gov/ix?doc=/Archives/edgar/data/0000882291/000168316824004660/aethlon_8k.htm">July 3, 2024</A>, <A HREF="https://www.sec.gov/ix?doc=/Archives/edgar/data/0000882291/000168316824005445/aethlon_8k.htm">August
12, 2024</A>, <A HREF="https://www.sec.gov/ix?doc=/Archives/edgar/data/0000882291/000168316824006522/aethlon_8k.htm">September 19, 2024</A>,
<A HREF="https://www.sec.gov/ix?doc=/Archives/edgar/data/0000882291/000168316824006850/aethlon_8k.htm">October 2, 2024</A>; <A HREF="https://www.sec.gov/ix?doc=/Archives/edgar/data/0000882291/000168316824006896/aethlon_8k.htm">October
3, 2024</A>, and <A HREF="http://www.sec.gov/Archives/edgar/data/882291/000168316824007858/aethlon_8k.htm" STYLE="-sec-extract: exhibit">November 12, 2024</A>; and</TD>
</TR>
<TR STYLE="vertical-align: top">
<TD STYLE="text-align: justify; width: 20pt"></TD><TD STYLE="width: 20pt; text-align: justify">&nbsp;</TD><TD STYLE="text-align: justify">&nbsp;</TD>
</TR>
<TR STYLE="vertical-align: top">
<TD STYLE="text-align: justify; width: 20pt"></TD><TD STYLE="width: 20pt; text-align: justify"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD STYLE="text-align: justify">The description of the Company&rsquo;s Common Stock contained
in the Company&rsquo;s Registration Statement on <A HREF="https://www.sec.gov/Archives/edgar/data/882291/000101968715002644/aethlon_8a12b.htm">Form
8-A</A>, filed by the Company with the Commission under Section 12(b) of the Exchange Act, on July 8, 2015, including any amendments
or reports filed for the purpose of updating such description, including <A HREF="https://www.sec.gov/Archives/edgar/data/882291/000168316820002070/aethlon_ex4016.htm">Exhibit
4.16</A> to the Company&rsquo;s Annual Report on Form 10-K for the fiscal year ended March 31, 2020, filed with the Commission on June
25, 2020.</TD>
</TR></TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">All reports and other documents filed by the Company
pursuant to Sections 13(a), 13(c), 14 or 15(d) of the Exchange Act, other than Current Reports furnished under Item 2.02 or Item 7.01
of Form 8-K and exhibits furnished on such form that relate to such items, after the date of this Registration Statement and prior to
the filing of a post-effective amendment which indicates that all securities offered hereby have been sold or which deregisters all securities
then remaining unsold, shall be deemed to be incorporated by reference herein and to be a part of this Registration Statement from the
date of filing such reports and documents.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">Any statement contained in a document incorporated
by, or deemed incorporated by reference herein, shall be deemed to be modified or superseded for purposes of this registration statement
to the extent that a statement contained herein or in any other subsequently filed document which also is or is deemed to be incorporated
by reference herein modifies or supersedes such statement. Any statement so modified or superseded shall not be deemed, except as so modified
or superseded, to constitute a part of this registration statement.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0"></TD><TD STYLE="width: 1in"><B>Item 8</B></TD><TD><B>Exhibits</B></TD></TR></TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 27pt; text-indent: -27pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 27pt; text-indent: -27pt">(d)&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Exhibits</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 27pt; text-indent: -27pt">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
  <TR STYLE="vertical-align: bottom">
    <TD STYLE="text-align: center">&nbsp;</TD>
    <TD STYLE="text-align: center">&nbsp;</TD>
    <TD STYLE="border-bottom: Black 1pt solid; text-align: center">&nbsp;</TD>
    <TD STYLE="text-align: center">&nbsp;</TD>
    <TD COLSPAN="7" STYLE="border-bottom: Black 1pt solid; text-align: center"><B>Incorporation by Reference</B></TD></TR>
  <TR STYLE="vertical-align: bottom">
    <TD STYLE="width: 9%; text-align: center"><B>Exhibit Number</B></TD>
    <TD STYLE="width: 2%; text-align: center">&nbsp;</TD>
    <TD STYLE="width: 40%; border-bottom: Black 1pt solid; text-align: center"><B>Exhibit Description</B></TD>
    <TD STYLE="width: 2%; text-align: center">&nbsp;</TD>
    <TD STYLE="width: 7%; border-bottom: Black 1pt solid; text-align: center"><B>Form</B></TD>
    <TD STYLE="width: 2%; text-align: center">&nbsp;</TD>
    <TD STYLE="width: 14%; border-bottom: Black 1pt solid; text-align: center"><B>Filing Date</B></TD>
    <TD STYLE="width: 2%; text-align: center">&nbsp;</TD>
    <TD STYLE="width: 10%; border-bottom: Black 1pt solid; text-align: center"><B>Exhibit</B></TD>
    <TD STYLE="width: 2%; text-align: center">&nbsp;</TD>
    <TD STYLE="width: 10%; border-bottom: Black 1pt solid; text-align: center"><B>Filed Herewith</B></TD></TR>
  <TR STYLE="vertical-align: top">
    <TD STYLE="border-top: Black 1pt solid; text-align: center">4.1</TD>
    <TD STYLE="text-align: justify">&nbsp;</TD>
    <TD><A HREF="https://www.sec.gov/Archives/edgar/data/882291/000168316822006480/aethlon_ex0301.htm">Articles of Incorporation, as amended.</A></TD>
    <TD STYLE="text-align: justify">&nbsp;</TD>
    <TD STYLE="text-align: center">8-K</TD>
    <TD STYLE="text-align: justify">&nbsp;</TD>
    <TD STYLE="text-align: center">September 19, 2022</TD>
    <TD STYLE="text-align: justify">&nbsp;</TD>
    <TD STYLE="text-align: center">3.1</TD>
    <TD STYLE="text-align: justify">&nbsp;</TD>
    <TD STYLE="text-align: justify">&nbsp;</TD></TR>
  <TR STYLE="vertical-align: top">
    <TD STYLE="text-align: center">4.2</TD>
    <TD STYLE="text-align: justify">&nbsp;</TD>
    <TD STYLE="background-color: white"><A HREF="https://www.sec.gov/Archives/edgar/data/882291/000168316819002910/aethlon_8k-ex0301.htm">Amended and Restated Bylaws of the Company.</A></TD>
    <TD STYLE="text-align: justify">&nbsp;</TD>
    <TD STYLE="text-align: center">8-K</TD>
    <TD STYLE="text-align: justify">&nbsp;</TD>
    <TD STYLE="text-align: center">September 12, 2019</TD>
    <TD STYLE="text-align: justify">&nbsp;</TD>
    <TD STYLE="text-align: center">3.1</TD>
    <TD STYLE="text-align: justify">&nbsp;</TD>
    <TD STYLE="text-align: justify">&nbsp;</TD></TR>
  <TR STYLE="vertical-align: top">
    <TD STYLE="text-align: center">5.1</TD>
    <TD STYLE="text-align: justify">&nbsp;</TD>
    <TD><A HREF="aethlon_ex0501.htm">Opinion of Procopio, Cory, Hargreaves &amp; Savitch LLP.</A></TD>
    <TD STYLE="text-align: justify">&nbsp;</TD>
    <TD STYLE="text-align: center">&nbsp;</TD>
    <TD STYLE="text-align: justify">&nbsp;</TD>
    <TD STYLE="text-align: center">&nbsp;</TD>
    <TD STYLE="text-align: justify">&nbsp;</TD>
    <TD STYLE="text-align: center">&nbsp;</TD>
    <TD STYLE="text-align: justify">&nbsp;</TD>
    <TD STYLE="text-align: center">X</TD></TR>
  <TR STYLE="vertical-align: top">
    <TD STYLE="text-align: center">23.1</TD>
    <TD STYLE="text-align: justify">&nbsp;</TD>
    <TD><A HREF="aethlon_ex2301.htm">Consent of Baker Tilly US, LLP, independent registered public accounting firm.</A></TD>
    <TD STYLE="text-align: justify">&nbsp;</TD>
    <TD STYLE="text-align: center">&nbsp;</TD>
    <TD STYLE="text-align: justify">&nbsp;</TD>
    <TD STYLE="text-align: center">&nbsp;</TD>
    <TD STYLE="text-align: justify">&nbsp;</TD>
    <TD STYLE="text-align: center">&nbsp;</TD>
    <TD STYLE="text-align: justify">&nbsp;</TD>
    <TD STYLE="text-align: center">X</TD></TR>
  <TR STYLE="vertical-align: top">
    <TD STYLE="text-align: center">23.2</TD>
    <TD STYLE="text-align: justify">&nbsp;</TD>
    <TD>Consent of Procopio, Cory, Hargreaves &amp; Savitch LLP (incorporated by reference to <A HREF="aethlon_ex0501.htm">Exhibit 5.1</A> to this Registration Statement on Form S-8).</TD>
    <TD STYLE="text-align: justify">&nbsp;</TD>
    <TD STYLE="text-align: center">&nbsp;</TD>
    <TD STYLE="text-align: justify">&nbsp;</TD>
    <TD STYLE="text-align: center">&nbsp;</TD>
    <TD STYLE="text-align: justify">&nbsp;</TD>
    <TD STYLE="text-align: center">&nbsp;</TD>
    <TD STYLE="text-align: justify">&nbsp;</TD>
    <TD STYLE="text-align: center">X</TD></TR>
  <TR STYLE="vertical-align: top">
    <TD STYLE="text-align: center">24.1</TD>
    <TD STYLE="text-align: justify">&nbsp;</TD>
    <TD><A HREF="#poa">Power of Attorney</A> (included on the signature page hereto)</TD>
    <TD STYLE="text-align: justify">&nbsp;</TD>
    <TD STYLE="text-align: center">&nbsp;</TD>
    <TD STYLE="text-align: justify">&nbsp;</TD>
    <TD STYLE="text-align: center">&nbsp;</TD>
    <TD STYLE="text-align: justify">&nbsp;</TD>
    <TD STYLE="text-align: center">&nbsp;</TD>
    <TD STYLE="text-align: justify">&nbsp;</TD>
    <TD STYLE="text-align: center">X</TD></TR>
  <TR STYLE="vertical-align: top">
    <TD STYLE="text-align: center">99.1</TD>
    <TD STYLE="text-align: justify">&nbsp;</TD>
    <TD><A HREF="https://www.sec.gov/Archives/edgar/data/0000882291/000168316824006850/aethlon_ex1001.htm"><FONT STYLE="font-size: 10pt">Aethlon Medical, Inc. 2020 Equity Incentive Plan, as amended to date, Form of Restricted Stock Grant, Form of Option Grant and Agreement.</FONT></A></TD>
    <TD STYLE="text-align: justify">&nbsp;</TD>
    <TD STYLE="text-align: center">8-K</TD>
    <TD STYLE="text-align: justify">&nbsp;</TD>
    <TD STYLE="text-align: center">&nbsp;October 2, 2024</TD>
    <TD STYLE="text-align: justify">&nbsp;</TD>
    <TD STYLE="text-align: center">10.1 </TD>
    <TD STYLE="text-align: justify">&nbsp;</TD>
    <TD STYLE="text-align: center">&nbsp;</TD></TR>
  <TR STYLE="vertical-align: top">
    <TD STYLE="text-align: center">107</TD>
    <TD STYLE="text-align: justify">&nbsp;</TD>
    <TD><A HREF="aethlon_ex107.htm">Filing Fee Table</A></TD>
    <TD STYLE="text-align: justify">&nbsp;</TD>
    <TD STYLE="text-align: center">&nbsp;</TD>
    <TD STYLE="text-align: justify">&nbsp;</TD>
    <TD STYLE="text-align: center">&nbsp;</TD>
    <TD STYLE="text-align: justify">&nbsp;</TD>
    <TD STYLE="text-align: center">&nbsp;</TD>
    <TD STYLE="text-align: justify">&nbsp;</TD>
    <TD STYLE="text-align: center">X</TD></TR>
  </TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"></P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>SIGNATURES</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">Pursuant to the requirements of the Securities
Act of 1933, as amended, the registrant certifies that it has reasonable grounds to believe that it meets all of the requirements for
filing on Form S-8 and has duly caused this Registration Statement to be signed on its behalf by the undersigned, thereunto duly authorized,
in the City of San Diego, State of California, on November 15, 2024.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
  <TR STYLE="vertical-align: bottom">
    <TD STYLE="width: 50%">&nbsp;</TD>
    <TD STYLE="width: 50%"><B>Aethlon Medical, Inc.</B></TD></TR>
  <TR STYLE="vertical-align: bottom">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
  <TR STYLE="vertical-align: bottom">
    <TD>&nbsp;</TD>
    <TD><U>By: /s/ James B. Frakes</U></TD></TR>
  <TR>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: top">James B. Frakes</TD></TR>
  <TR>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: top">Chief Executive Officer and Chief Financial Officer</TD></TR>
  </TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B><A NAME="poa"></A>POWER OF ATTORNEY </B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">KNOW ALL PERSONS BY THESE PRESENTS, that each
person whose signature appears below hereby constitutes and appoints James B. Frakes as the undersigned&rsquo;s true and lawful attorney-in-fact
and agent, with full power of substitution and resubstitution for such person and in such person&rsquo;s name, place and stead, in any
and all capacities, to file and sign any and all amendments to this Registration Statement, including any and all post-effective amendments,
and to file such amendments thereto, with exhibits thereto and other documents in connection therewith, with the Commission, granting
unto said attorney-in-fact and agent, full power and authority to do and perform each and every act and thing requisite and necessary
to be done in connection therewith, as fully for all intents and purposes as he or she might or could do in person, hereby ratifying and
confirming all that said attorney-in-fact and agent, or his or her substitutes, may lawfully do or cause to be done by virtue hereof.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">***</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">Pursuant to the requirements of the Securities
Act of 1933, this registration statement has been signed below by the following persons in the capacities and on the dates indicated.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
  <TR>
    <TD STYLE="vertical-align: top; width: 30%; border-bottom: black 1pt solid; text-align: center"><B>Signature</B></TD>
    <TD STYLE="vertical-align: bottom; width: 2%">&nbsp;</TD>
    <TD STYLE="vertical-align: top; width: 44%; border-bottom: black 1pt solid; text-align: center"><B>Title</B></TD>
    <TD STYLE="vertical-align: bottom; width: 2%">&nbsp;</TD>
    <TD STYLE="vertical-align: top; width: 22%; border-bottom: black 1pt solid; text-align: center"><B>Date</B></TD></TR>
  <TR STYLE="vertical-align: bottom">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
  <TR>
    <TD STYLE="vertical-align: top; border-bottom: black 1pt solid">/s/ James B. Frakes</TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD ROWSPAN="2">
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">Chief Executive Officer, Chief Financial Officer
    and Director</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">(<I>Principal Executive, Financial and Accounting
    Officer</I>)</P></TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom">November 15, 2024</TD></TR>
  <TR STYLE="vertical-align: bottom">
    <TD>James B. Frakes</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
  <TR STYLE="vertical-align: bottom">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD STYLE="text-align: center">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
  <TR>
    <TD STYLE="vertical-align: top; border-bottom: black 1pt solid">/s/ Edward G. Broenniman</TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD ROWSPAN="2" STYLE="text-align: center">Chairman of the Board, Director</TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom">November 15, 2024</TD></TR>
  <TR STYLE="vertical-align: bottom">
    <TD>Edward G. Broenniman</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
  <TR STYLE="vertical-align: bottom">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD STYLE="text-align: center">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
  <TR>
    <TD STYLE="vertical-align: top; border-bottom: black 1pt solid">/s/ Chetan Shah, MD</TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD ROWSPAN="2" STYLE="vertical-align: top">
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">Director</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P></TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom">November 15, 2024</TD></TR>
  <TR>
    <TD STYLE="vertical-align: top">Chetan Shah, MD</TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD></TR>
  <TR>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: top; text-align: center">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD></TR>
  <TR>
    <TD STYLE="vertical-align: top; border-bottom: black 1pt solid">/s/ Angela Rossetti</TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD ROWSPAN="2" STYLE="vertical-align: top; text-align: center">Director</TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom">November 15, 2024</TD></TR>
  <TR>
    <TD STYLE="vertical-align: top">Angela Rossetti</TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD></TR>
  <TR>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: top; text-align: center">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD></TR>
  <TR>
    <TD STYLE="vertical-align: top; border-bottom: black 1pt solid">/s/ Nicolas Gikakis</TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: top; text-align: center">Director</TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom">November 15, 2024</TD></TR>
  <TR>
    <TD STYLE="vertical-align: top">Nicolas Gikakis</TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: top; text-align: center">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD></TR>
  </TABLE>

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[{"type": "S-8", "sequence": "1", "filename": "aethlon_s8.htm", "description": "S-8", "secsgml_size_bytes": 39114}]
{"company-data": {"conformed-name": "AETHLON MEDICAL INC", "cik": "0000882291", "assigned-sic": "3841", "organization-name": "08 Industrial Applications and Services", "irs-number": "133632859", "state-of-incorporation": "NV", "fiscal-year-end": "0331"}, "filing-values": {"form-type": "S-8", "act": "33", "file-number": "333-283271", "film-number": "241468535"}, "business-address": {"street1": "11555 SORRENTO VALLEY ROAD, SUITE 203", "city": "SAN DIEGO", "state": "CA", "zip": "92121", "phone": "619-941-0360"}, "mail-address": {"street1": "11555 SORRENTO VALLEY ROAD, SUITE 203", "city": "SAN DIEGO", "state": "CA", "zip": "92121"}, "former-company": {"former-conformed-name": "BISHOP EQUITIES INC", "date-changed": "19930602"}}
As filed with the Securities and Exchange Commission
on November 15, 2024
Registration No. 333-
UNITED STATES
SECURITIES AND EXCHANGE COMMISSION
WASHINGTON, D.C. 20549
____________
FORM S-8
REGISTRATION STATEMENT
UNDER
THE SECURITIES ACT OF 1933
____________
Aethlon Medical, Inc.
(Exact name of registrant as specified in its charter)
____________
Nevada
13-3632859
(State or other jurisdiction of incorporation)
(I.R.S. Employer Identification No.)
11555 Sorrento Valley Road, Suite 203
San Diego, California 92121
(Address of principal executive offices) (Zip Code)
____________
Aethlon Medical, Inc. 2020 Equity Incentive
Plan
(Full title of the plan)
____________
James B. Frakes
Chief Executive Officer and Chief Financial
Officer
Aethlon Medical, Inc.
11555 Sorrento Valley Road, Suite 203
San Diego, California 92121
(619) 941-0360
(Name, address, and telephone number, including
area code, of agent for service)
____________
Copies to
:
Dennis J. Doucette, Esq.
Procopio, Cory, Hargreaves & Savitch LLP
12544 High Bluff Drive, Suite 400
San Diego, CA 92130
(858) 720-6300
Indicate by check mark whether the registrant
is a large accelerated filer, an accelerated filer, a non-accelerated filer, a smaller reporting company or an emerging growth company.
See the definitions of "large accelerated filer," "accelerated filer," "smaller reporting company,"
and "emerging growth company" in Rule 12b-2 of the Exchange Act.
Large accelerated Filer
☐
Accelerated Filer
☐
Non-accelerated Filer
☒
Smaller reporting company
☒
Emerging Growth Company
☐
If an emerging growth company, indicate by check
mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting
standards provided pursuant to Section 7(a)(2)(B) of the Securities Act
☐
REGISTRATION OF ADDITIONAL
SHARES PURSUANT TO GENERAL INSTRUCTION E
Pursuant to General Instruction E of Form S-8,
Aethlon Medical, Inc. (the "Company") is filing this Registration Statement on Form S-8 (this "Registration Statement")
to register an additional 3,000,000 shares of Company common stock, par value $0.001 per share ("Common Stock"), for issuance
under the Company's 2020 Equity Incentive Plan (the "Original Plan"), as amended on September 15, 2022 (the "First
Amendment") and September 27, 2024 (the "Second Amendment," and together with the Original Plan and the First Amendment,
the "2020 Plan"). Such additional shares of Common Stock were added to the 2020 Plan pursuant to the Second Amendment and
are in addition to the 364,256 shares of Common Stock (as adjusted for the Reverse Stock Split, as defined below) issuable pursuant to
the 2020 Plan registered on the Company's Registration Statements on Form S-8 filed with the Securities and Exchange Commission
(the "Commission") on September 15, 2020 (Commission File No.
333-248820
)
and September 19, 2022 (Commission File No.
333-267504
),
the contents of which are hereby incorporated by reference into this Registration Statement, except to the extent supplemented, amended
or superseded by the information set forth in this Registration Statement or by any subsequently filed document.
On October 4, 2023, the Company effected a one-for-ten
reverse stock split of the Company's issued and outstanding shares of Common Stock (the "Reverse Stock Split"). As a
result of the Reverse Stock Split, every ten shares of Common Stock issued and outstanding as of 5:00 p.m. Eastern Time on October 4,
2023 were combined into one share of Common Stock. The number of shares issuable pursuant to 2020 Plan were also adjusted proportionally
as a result of the Reverse Stock Split.
2
PART II
INFORMATION REQUIRED IN REGISTRATION STATEMENT
Item 3. Incorporation of Documents by Reference.
The following documents, which have been filed
by the Company with the Commission pursuant to the Securities Act of 1933, as amended, and the Securities Exchange Act of 1934, as amended
(the "Exchange Act"), are incorporated herein by reference:
·
The Company's
Annual
Report on Form 10-K
for the fiscal year ended March 31, 2024, filed with the Commission on June 27, 2024, and
Amendment
No. 1
to the Company's Annual Report on Form 10-K, filed with the Commission on August 15, 2024;
·
The Company's
Quarterly
Report on Form 10-Q
for the quarter ended June 30, 2024, filed with the Commission on August 14, 2024;
·
The Company's
Quarterly
Report on Form 10-Q
for the quarter ended September 30, 2024, filed with the Commission on November 13, 2024;
·
The Company's Current Reports on Form 8-K, filed with the
Commission on
April 25, 2024
,
May 10, 2024
,
May
17, 2024
,
May 24, 2024
,
July 3, 2024
,
August
12, 2024
,
September 19, 2024
,
October 2, 2024
;
October
3, 2024
, and
November 12, 2024
; and
·
The description of the Company's Common Stock contained
in the Company's Registration Statement on
Form
8-A
, filed by the Company with the Commission under Section 12(b) of the Exchange Act, on July 8, 2015, including any amendments
or reports filed for the purpose of updating such description, including
Exhibit
4.16
to the Company's Annual Report on Form 10-K for the fiscal year ended March 31, 2020, filed with the Commission on June
25, 2020.
All reports and other documents filed by the Company
pursuant to Sections 13(a), 13(c), 14 or 15(d) of the Exchange Act, other than Current Reports furnished under Item 2.02 or Item 7.01
of Form 8-K and exhibits furnished on such form that relate to such items, after the date of this Registration Statement and prior to
the filing of a post-effective amendment which indicates that all securities offered hereby have been sold or which deregisters all securities
then remaining unsold, shall be deemed to be incorporated by reference herein and to be a part of this Registration Statement from the
date of filing such reports and documents.
Any statement contained in a document incorporated
by, or deemed incorporated by reference herein, shall be deemed to be modified or superseded for purposes of this registration statement
to the extent that a statement contained herein or in any other subsequently filed document which also is or is deemed to be incorporated
by reference herein modifies or supersedes such statement. Any statement so modified or superseded shall not be deemed, except as so modified
or superseded, to constitute a part of this registration statement.
Item 8
Exhibits
(d)       Exhibits
Incorporation by Reference
Exhibit Number
Exhibit Description
Form
Filing Date
Exhibit
Filed Herewith
4.1
Articles of Incorporation, as amended.
8-K
September 19, 2022
3.1
4.2
Amended and Restated Bylaws of the Company.
8-K
September 12, 2019
3.1
5.1
Opinion of Procopio, Cory, Hargreaves & Savitch LLP.
X
23.1
Consent of Baker Tilly US, LLP, independent registered public accounting firm.
X
23.2
Consent of Procopio, Cory, Hargreaves & Savitch LLP (incorporated by reference to
Exhibit 5.1
to this Registration Statement on Form S-8).
X
24.1
Power of Attorney
(included on the signature page hereto)
X
99.1
Aethlon Medical, Inc. 2020 Equity Incentive Plan, as amended to date, Form of Restricted Stock Grant, Form of Option Grant and Agreement.
8-K
October 2, 2024
10.1
107
Filing Fee Table
X
3
SIGNATURES
Pursuant to the requirements of the Securities
Act of 1933, as amended, the registrant certifies that it has reasonable grounds to believe that it meets all of the requirements for
filing on Form S-8 and has duly caused this Registration Statement to be signed on its behalf by the undersigned, thereunto duly authorized,
in the City of San Diego, State of California, on November 15, 2024.
Aethlon Medical, Inc.
By: /s/ James B. Frakes
James B. Frakes
Chief Executive Officer and Chief Financial Officer
POWER OF ATTORNEY
KNOW ALL PERSONS BY THESE PRESENTS, that each
person whose signature appears below hereby constitutes and appoints James B. Frakes as the undersigned's true and lawful attorney-in-fact
and agent, with full power of substitution and resubstitution for such person and in such person's name, place and stead, in any
and all capacities, to file and sign any and all amendments to this Registration Statement, including any and all post-effective amendments,
and to file such amendments thereto, with exhibits thereto and other documents in connection therewith, with the Commission, granting
unto said attorney-in-fact and agent, full power and authority to do and perform each and every act and thing requisite and necessary
to be done in connection therewith, as fully for all intents and purposes as he or she might or could do in person, hereby ratifying and
confirming all that said attorney-in-fact and agent, or his or her substitutes, may lawfully do or cause to be done by virtue hereof.
***
Pursuant to the requirements of the Securities
Act of 1933, this registration statement has been signed below by the following persons in the capacities and on the dates indicated.
Signature
Title
Date
/s/ James B. Frakes
Chief Executive Officer, Chief Financial Officer
    and Director
(
Principal Executive, Financial and Accounting
    Officer
)
November 15, 2024
James B. Frakes
/s/ Edward G. Broenniman
Chairman of the Board, Director
November 15, 2024
Edward G. Broenniman
/s/ Chetan Shah, MD
Director
November 15, 2024
Chetan Shah, MD
/s/ Angela Rossetti
Director
November 15, 2024
Angela Rossetti
/s/ Nicolas Gikakis
Director
November 15, 2024
Nicolas Gikakis
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