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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">As filed with the Securities and Exchange
Commission on October 30, 2015</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: right">Registration No. 333-</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>UNITED STATES</B>&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>SECURITIES AND EXCHANGE COMMISSION</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>Washington, D.C. 20549</B></P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>FORM S-8</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>REGISTRATION STATEMENT</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B><I>UNDER</I></B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><FONT STYLE="font-family: Times New Roman, Times, Serif"><B><I>THE
SECURITIES ACT OF 1933</I></B></FONT></P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>RITTER PHARMACEUTICALS, INC.</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">(Exact name of registrant as specified in
its charter)</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>
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<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%">
<tr>
    <TD STYLE="vertical-align: top; width: 45%; text-align: center"><font style="font: 10pt Times New Roman, Times, Serif"><b>Delaware</b></font></td>
    <TD STYLE="vertical-align: bottom; width: 10%">&nbsp;</td>
    <TD STYLE="vertical-align: top; width: 45%; padding-left: 67.5pt; text-align: center"><font style="font: 10pt Times New Roman, Times, Serif"><b>20-1295171</b></font></td></tr>
<tr>
    <TD STYLE="vertical-align: top; text-align: center"><font style="font-size: 10pt">(State or other jurisdiction of</font></td>
    <TD STYLE="vertical-align: bottom">&nbsp;</td>
    <TD STYLE="vertical-align: top; padding-left: 76.5pt; text-align: center"><font style="font-size: 10pt">(I.R.S. Employer </font></td></tr>
<tr>
    <TD STYLE="vertical-align: top; text-align: center"><font style="font-size: 10pt">incorporation or organization)</font></td>
    <TD STYLE="vertical-align: bottom">&nbsp;</td>
    <TD STYLE="vertical-align: top; padding-left: 76.5pt; text-align: center"><font style="font-size: 10pt">Identification Number)</font></td></tr>
</table>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>&nbsp;</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>Ritter Pharmaceuticals, Inc.</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>1880 Century Park East, Suite 1000</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>Los Angeles, CA 90067</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>(310) 203-1000</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">(Address of Principal Executive Offices)</P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>RITTER PHARMACEUTICALS, INC. 2008 STOCK
PLAN</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>RITTER PHARMACEUTICALS, INC. 2009 STOCK
PLAN</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>RITTER PHARMACEUTICALS, INC. 2015 EQUITY
INCENTIVE PLAN</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">(Full title of the plans)</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>&nbsp;</B></P>
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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>Michael D. Step</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>Chief Executive Officer</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>Ritter Pharmaceuticals, Inc.</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>1880 Century Park East, Suite 1000</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>Los Angeles, CA 90067</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>(310) 203-1000 </B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">(Name, address and telephone number (including
area code) of agent for service)</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>&nbsp;</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><I>Copy to:</I></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><I>&nbsp;</I></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>Michael Sanders, Esq.</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>David Mittelman, Esq.</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>Deborah Gunny, Esq.</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>Reed Smith LLP</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>1901 Avenue of the Stars</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>Suite 700</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>Los Angeles, CA 90067-6708</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>(310) 734-5200</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>(310) 734-5299 Facsimile</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"></P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Indicate by check mark whether the registrant is a large accelerated
filer, an accelerated filer, a non-accelerated filer or a smaller reporting company. See definitions of &ldquo;large accelerated
filer,&rdquo; &ldquo;accelerated filer&rdquo; and &ldquo;smaller reporting company&rdquo; in Rule 12b-2 of the Exchange Act (check
one):</P>

<TABLE CELLSPACING="0" CELLPADDING="0" ALIGN="CENTER" STYLE="font: 10pt Times New Roman, Times, Serif; width: 80%; border-collapse: collapse">
<tr style="vertical-align: top">
    <TD STYLE="width: 55%"><font style="font-size: 10pt">Large accelerated filer&nbsp;<font style="font-family: Wingdings">&#168;</font> </font></td>
    <TD STYLE="width: 45%"><font style="font-size: 10pt">Accelerated filer&nbsp;&nbsp;<font style="font-family: Wingdings">&#168;</font></font></td></tr>
<tr style="vertical-align: top">
    <TD>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Non-accelerated filer <font style="font-family: Wingdings">&#168;</font></P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">(Do not check if a smaller reporting company)</P></td>
    <TD><font style="font-size: 10pt">Smaller reporting company&nbsp;&nbsp;<font style="font-family: Wingdings">x</font></font></td></tr>
</table>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>


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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B>&nbsp;</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>CALCULATION OF REGISTRATION FEE</B></P>

<table cellspacing="0" cellpadding="0" style="border: black 1pt outset; font: 10pt Times New Roman, Times, Serif; width: 100%">
<tr style="vertical-align: bottom">
    <td style="width: 21%; border-top: black 1pt inset; border-right: black 1pt inset; border-left: black 1pt inset; border-bottom: black 1pt solid; text-align: center"><font style="font-size: 10pt">&nbsp;</font><br>
<font style="font-size: 10pt"><b>Title&nbsp;of&nbsp;Securities&nbsp;to&nbsp;be</b></font><br>
<font style="font-size: 10pt"><b>registered</b></font></td>
    <td style="width: 20%; border-top: black 1pt inset; border-right: black 1pt inset; border-left: black 1pt inset; border-bottom: black 1pt solid; text-align: center"><FONT STYLE="font-size: 10pt"><B>Amount&nbsp;to&nbsp;be&nbsp;<BR>
registered&nbsp;<FONT STYLE="font-family: Times New Roman, Times, Serif"><SUP>(1)</SUP></FONT></B></FONT>&nbsp;</td>
    <td style="width: 19%; border-top: black 1pt inset; border-right: black 1pt inset; border-left: black 1pt inset; border-bottom: black 1pt solid; text-align: center"><font style="font-size: 10pt"><b>Proposed&nbsp;maximum</b></font><br>
<font style="font-size: 10pt"><b>offering</b></font><br>
<font style="font-size: 10pt"><b>price&nbsp;per&nbsp;share</b></font></td>
    <td style="width: 20%; border-top: black 1pt inset; border-right: black 1pt inset; border-left: black 1pt inset; border-bottom: black 1pt solid; text-align: center"><font style="font-size: 10pt"><b>Proposed&nbsp;maximum</b></font><br>
<font style="font-size: 10pt"><b>aggregate</b></font><br>
<font style="font-size: 10pt"><b>offering&nbsp;price</b></font></td>
    <td style="width: 20%; border-top: black 1pt inset; border-right: black 1pt inset; border-left: black 1pt inset; border-bottom: black 1pt solid; text-align: center"><FONT STYLE="font-size: 10pt"><B>Amount&nbsp;of&nbsp;registration&nbsp;<BR>
fee</B></FONT></td></tr>
<tr style="background-color: #CCFFCC">
    <td style="border: black 1pt inset; text-align: center"><font style="font-size: 10pt">Common Stock, $0.001 par value per share</font></td>
    <td style="border: black 1pt inset; text-align: center"><font style="font-size: 10pt">1,886,633 shares <font style="font-family: Times New Roman, Times, Serif"><b><sup>(2)</sup></b></font></font></td>
    <td style="border: black 1pt inset; text-align: center"><font style="font-size: 10pt">$7.228 <font style="font-family: Times New Roman, Times, Serif"><b><sup>(3)</sup></b></font></font></td>
    <td style="border: black 1pt inset; text-align: center"><font style="font-size: 10pt">$13,636,583.32</font></td>
    <td style="border: black 1pt inset; text-align: center"><font style="font-size: 10pt">$1,373.20</font></td></tr>
<tr style="background-color: #CCFFCC">
    <td style="border: black 1pt inset; text-align: center"><font style="font-size: 10pt">Common Stock, $0.001 par value per share </font></td>
    <td style="border: black 1pt inset; text-align: center"><font style="font-size: 10pt">18,601 shares <font style="font-family: Times New Roman, Times, Serif"><b><sup>(4)</sup></b></font></font></td>
    <td style="border: black 1pt inset; text-align: center"><FONT STYLE="font-size: 10pt">$0.715 <FONT STYLE="font-family: Times New Roman, Times, Serif"><B><SUP>(5)</SUP></B></FONT></FONT></td>
    <td style="border: black 1pt inset; text-align: center"><FONT STYLE="font-size: 10pt">$13,299.72</FONT></td>
    <td style="border: black 1pt inset; text-align: center"><FONT STYLE="font-size: 10pt">$1.34</FONT></td></tr>
<tr style="background-color: #CCFFCC">
    <td style="border: black 1pt inset; text-align: center"><font style="font-size: 10pt">Common Stock, $0.001 par value per share</font></td>
    <td style="border: black 1pt inset; text-align: center"><FONT STYLE="font-size: 10pt">2,111,682 shares <FONT STYLE="font-family: Times New Roman, Times, Serif"><B><SUP>(6)</SUP></B></FONT></FONT></td>
    <td style="border: black 1pt inset; text-align: center"><font style="font-size: 10pt">$2.23 <font style="font-family: Times New Roman, Times, Serif"><b><sup>(7)</sup></b></font></font></td>
    <td style="border: black 1pt inset; text-align: center"><FONT STYLE="font-size: 10pt">$4,709,050.86</FONT></td>
    <td style="border: black 1pt inset; text-align: center"><font style="font-size: 10pt">$474.20</font></td></tr>
</table>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">(1) Pursuant to Rule 416(a) under the Securities
Act of 1933, as amended (the &ldquo;Securities Act&rdquo;), this Registration Statement also covers an indeterminate number of
additional shares of common stock, par value $0.001 per share (the &ldquo;Common Stock&rdquo;) of Ritter Pharmaceuticals, Inc.
(the &ldquo;Company&rdquo;) that may be offered or sold under the Ritter Pharmaceuticals, Inc. 2008 Stock Plan (the &ldquo;2008
Plan&rdquo;), the Ritter Pharmaceuticals, Inc. 2009 Stock Plan (the &ldquo;2009 Plan&rdquo;), and the Ritter Pharmaceuticals, Inc. 2015
Equity Incentive Plan (the &ldquo;2015 Plan&rdquo;) by reason of any substitutions or adjustments to shares to account for any
change in capitalization, including any stock dividend, stock split, reverse stock split, split up, spin-off, recapitalization,
or other distribution of stock or property of the Company, combination or exchange of shares or common stock, dividend in kind,
or other like change in capital structure.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">(2) Represents shares of Common Stock subject
to stock options presently outstanding under the 2008 Plan. To the extent such awards are forfeited or lapse unexercised or are
settled in cash and are not issued under the 2008 Plan, the Common Stock subject to such awards will be available for future issuance
under the 2015 Plan.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">(3) Estimated in accordance with Rule 457(h)
of the Securities Act solely for the purpose of calculating the registration fee on the basis of the weighted average exercise
price of $7.085 per share for outstanding stock options granted under the 2008 Plan.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">(4) Represents shares of Common Stock subject
to stock options presently outstanding under the 2009 Plan. To the extent such awards are forfeited or lapse unexercised or are
settled in cash and are not issued under the 2009 Plan, the Common Stock subject to such awards will be available for future issuance
under the 2015 Plan.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">(5) Estimated in accordance with Rule 457(h)
of the Securities Act solely for the purpose of calculating the registration fee on the basis of the weighted average exercise
price of $0.72 per share for outstanding stock options granted under the 2009 Plan.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">(6) Represents shares of Common Stock
available for future issuance under the 2015 Plan, which number consists of (a) 206,448 shares of Common Stock presently
available for issuance under the 2015 Plan and (b) up to an additional 1,905,234 shares of Common Stock that may become issuable
under the 2015 Plan pursuant to its terms to the extent presently outstanding awards under the 2008 Plan and 2009 Plan are forfeited
or lapse unexercised or are settled in cash. The additional 1,905,234 shares of Common Stock represent the aggregate of 1,886,633
shares under the 2008 Plan corresponding to footnote (2) and the 18,601 shares under the 2009 Plan corresponding to footnote (4)
of this Calculation of Registration Fee table.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">(7) Estimated in accordance with Rule 457(h)
of the Securities Act solely for the purpose of calculating the registration fee. In accordance with Rule 457(c) of the Securities
Act, the offering price per share are based upon the average of the high and low prices, which were $2.15 and $2.31, for the Common
Stock of the Company as reported on the NASDAQ Stock Market on October 27, 2015.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>&nbsp;</B></P>
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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B>&nbsp;</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>PART I</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>INFORMATION REQUIRED IN THE SECTION 10(a)
PROSPECTUS</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.5in">The information required
by Part I is included in one or more documents to be sent or given to participants in the 2008 Plan, the 2009 Plan, and the 2015
Plan pursuant to Rule 428 under the Securities Act. In accordance with the rules and regulations of the Securities and Exchange
Commission (the &ldquo;Commission&rdquo;), and the instructions to Form S-8, such documents are not being filed with the Commission
either as a part of this Registration Statement or as prospectuses or prospectus supplements pursuant to Rule 424 under the Securities
Act.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>PART II</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>INFORMATION REQUIRED IN THE REGISTRATION
STATEMENT</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B>Item 3. Incorporation of Documents by Reference.</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.5in">The following documents
previously filed with the Commission are hereby incorporated by reference into this Registration Statement:</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in; text-align: justify"><FONT STYLE="font-size: 10pt">(a)</FONT>&nbsp;&nbsp;&nbsp;<FONT STYLE="font-size: 10pt">the
Company&rsquo;s prospectus filed on June 26, 2015 pursuant to Rule 424(b) of the Securities Act relating to the Company&rsquo;s
Registration Statement on Form S-1 (File No. 333-202924) that contains audited financial statements of the Company for the latest
fiscal year for which such statements have been filed; </FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in; text-align: justify">(b)&nbsp;&nbsp;&nbsp;the Company&rsquo;s quarterly
report on Form 10-Q for the fiscal period ended June 30, 2015 filed on August 12, 2015;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in; text-align: justify">(c)&nbsp;&nbsp;&nbsp;the Company&rsquo;s current
reports on Form 8-K filed on July 1, 2015, July 14, 2015, July 27, 2015, September 22, 2015, and October 26, 2015; and</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in; text-align: justify">(d)&nbsp;&nbsp;&nbsp;the description of the
Company&rsquo;s Common Stock contained in the Company&rsquo; Registration Statement on Form 8-A (File No. 1-37428) filed on June
15, 2015, including any amendment or report filed for the purpose of updating such description.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.5in">In addition, all documents
that the Company files pursuant to Sections 13(a), 13(c), 14 and 15(d) of the Exchange Act of 1934, as amended (the &ldquo;Exchange
Act&rdquo;), subsequent to the filing of this Registration Statement and prior to the filing of a post-effective amendment which
indicates that all securities offered hereby have been sold or which deregisters all securities then remaining unsold, shall be
deemed to be incorporated by reference into this Registration Statement and to be a part hereof from the date of filing of such
documents, except as to any document or portion of any document that is deemed furnished and not filed.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.5in">Pursuant to Rule 412
under the Securities Act, any statement contained in the documents incorporated or deemed to be incorporated by reference in this
Registration Statement shall be deemed to be modified, superseded or replaced for purposes of this Registration Statement to the
extent that a statement contained herein or in any other subsequently filed document which also is incorporated or deemed to be
incorporated by reference in this Registration Statement modifies, supersedes or replaces such statement. Any such statement so
modified, superseded or replaced shall not be deemed, except as so modified, superseded or replaced, to constitute a part of this
Registration Statement.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.5in">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 0"><TR STYLE="vertical-align: top; text-align: justify">
<TD STYLE="width: 0"></TD><TD STYLE="width: 0.5in; text-align: left"><B>Item&nbsp;4.</B></TD><TD STYLE="text-align: justify"><B>Description of Securities.</B></TD>
</TR></TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.5in">Not applicable.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"></P>

<!-- Field: Page; Sequence: 3 -->
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    <DIV STYLE="page-break-before: always; margin-top: 6pt; margin-bottom: 12pt"><P STYLE="margin: 0pt">&nbsp;</P></DIV>
    <!-- Field: /Page -->

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 0"><TR STYLE="vertical-align: top; text-align: justify">
<TD STYLE="width: 0"></TD><TD STYLE="width: 0.5in; text-align: left"><B>Item&nbsp;5.</B></TD><TD STYLE="text-align: justify"><B>Interests of Named Experts and Counsel.</B></TD>
</TR></TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.5in">Not applicable.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.5in">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 0"><TR STYLE="vertical-align: top; text-align: justify">
<TD STYLE="width: 0"></TD><TD STYLE="width: 0.5in; text-align: left"><B>Item&nbsp;6.</B></TD><TD STYLE="text-align: justify"><B>Indemnification of Directors and Officers.</B></TD>
</TR></TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.5in">The Company&rsquo;s
restated certificate of incorporation provides that the Company shall indemnify, to the fullest extent authorized by the Delaware
General Corporation Law, each person who is involved in any litigation or other proceeding because such person is or was a director
or officer of the Company or is or was serving as an officer or director of another entity at the Company&rsquo;s request, against
all expense, loss or liability reasonably incurred or suffered in connection therewith. The Company&rsquo;s certificate of incorporation
provides that the right to indemnification includes the right to be paid expenses incurred in defending any proceeding in advance
of its final disposition, provided, however, that such advance payment will only be made upon delivery to us of an undertaking,
by or on behalf of the director or officer, to repay all amounts so advanced if it is ultimately determined that such director
is not entitled to indemnification. If the Company does not pay a proper claim for indemnification in full within 30 days after
receiving a written claim for such indemnification, the Company&rsquo;s certificate of incorporation and bylaws authorize the claimant
to bring an action against the Company and prescribe what constitutes a defense to such action.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.5in">Section 145 of the
Delaware General Corporation Law permits a corporation to indemnify any director or officer of the corporation against expenses
(including attorney&rsquo;s fees), judgments, fines and amounts paid in settlement actually and reasonably incurred in connection
with any action, suit or proceeding brought by reason of the fact that such person is or was a director or officer of the corporation,
if such person acted in good faith and in a manner that he reasonably believed to be in, or not opposed to, the best interests
of the corporation, and, with respect to any criminal action or proceeding, if he or she had no reason to believe his or her conduct
was unlawful. In a derivative action, (i.e., one brought by or on behalf of the corporation), indemnification may be provided only
for expenses actually and reasonably incurred by any director or officer in connection with the defense or settlement of such an
action or suit if such person acted in good faith and in a manner that he or she reasonably believed to be in, or not opposed to,
the best interests of the corporation, except that no indemnification shall be provided if such person shall have been adjudged
to be liable to the corporation, unless and only to the extent that the court in which the action or suit was brought shall determine
that the defendant is fairly and reasonably entitled to indemnity for such expenses despite such adjudication of liability.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.5in">Pursuant to Section
102(b)(7) of the Delaware General Corporation Law, the Company&rsquo;s certificate of incorporation eliminates the liability of
a director to the Company or its stockholders for monetary damages for such a breach of fiduciary duty as a director, except for
liabilities arising:</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.5in">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 0"><TR STYLE="vertical-align: top; text-align: justify">
<TD STYLE="width: 0.5in"></TD><TD STYLE="width: 0.25in; text-align: left">&bull;</TD><TD STYLE="text-align: justify">from any breach of the director&rsquo;s duty of loyalty
to the Company or its stockholders;</TD>
</TR></TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.5in">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.5in"></TD><TD STYLE="width: 0.25in">&bull;</TD><TD STYLE="text-align: justify">from acts or omissions not in good faith or which involve intentional misconduct or a knowing violation
of law;</TD></TR></TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.5in">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 0"><TR STYLE="vertical-align: top; text-align: justify">
<TD STYLE="width: 0.5in"></TD><TD STYLE="width: 0.25in; text-align: left">&bull;</TD><TD STYLE="text-align: justify">under Section 174 of the Delaware General Corporation Law;
or</TD>
</TR></TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.5in">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 0"><TR STYLE="vertical-align: top; text-align: justify">
<TD STYLE="width: 0.5in"></TD><TD STYLE="width: 0.25in; text-align: left">&bull;</TD><TD STYLE="text-align: justify">from any transaction from which the director derived an
improper personal benefit.</TD>
</TR></TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.5in">The Company carries
insurance policies insuring the Company&rsquo;s directors and officers against certain liabilities that they may incur in their
capacity as directors and officers.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.5in">In addition, the Company
has entered into indemnification agreements with each of the Company&rsquo;s current directors and executive officers. These agreements
require the Company to indemnify these individuals to the fullest extent permitted under Delaware law against liabilities that
may arise by reason of their service to the Company and to advance expenses incurred as a result of any proceeding against them
as to which they could be indemnified. The Company also intends to enter into indemnification agreements with future directors
and executive officers of the Company.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.5in">&nbsp;</P>


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    <DIV STYLE="page-break-before: always; margin-top: 6pt; margin-bottom: 12pt"><P STYLE="margin: 0pt">&nbsp;</P></DIV>
    <!-- Field: /Page -->

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 0"><TR STYLE="vertical-align: top; text-align: justify">
<TD STYLE="width: 0"></TD><TD STYLE="width: 0.5in; text-align: left"><B>Item&nbsp;7.</B></TD><TD STYLE="text-align: justify"><B>Exemption from Registration Claimed.</B></TD>
</TR></TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.5in">Not applicable.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B>&nbsp;</B></P>

<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 0"><TR STYLE="vertical-align: top; text-align: justify">
<TD STYLE="width: 0"></TD><TD STYLE="width: 0.5in; text-align: left"><B>Item&nbsp;8.</B></TD><TD STYLE="text-align: justify"><B>Exhibits.</B></TD>
</TR></TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">The Exhibit Index immediately preceding
the exhibits is incorporated in this Item 8 by reference.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 0"><TR STYLE="vertical-align: top; text-align: justify">
<TD STYLE="width: 0"></TD><TD STYLE="width: 0.5in; text-align: left"><B>Item&nbsp;9.</B></TD><TD STYLE="text-align: justify"><B>Undertakings.</B></TD>
</TR></TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 0"><TR STYLE="vertical-align: top; text-align: justify">
<TD STYLE="width: 0"></TD><TD STYLE="width: 0.5in; text-align: left">(a)</TD><TD STYLE="text-align: justify">The undersigned registrant hereby undertakes:</TD>
</TR></TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.5in">(1) To file, during
any period in which offers or sales are being made, a post-effective amendment to this Registration Statement:</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in; text-align: justify; text-indent: 0.5in">(i) To include
any prospectus required by Section 10(a)(3) of the Securities Act;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in; text-align: justify; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in; text-align: justify; text-indent: 0.5in">(ii) To reflect
in the prospectus any facts or events arising after the effective date of the Registration Statement (or the most recent post-effective
amendment thereof) which, individually or in the aggregate, represent a fundamental change in the information set forth in this
Registration Statement; and</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in; text-align: justify; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in; text-align: justify; text-indent: 0.5in">(iii) To
include any material information with respect to the plan of distribution not previously disclosed in this Registration Statement
or any material change to such information in this Registration Statement;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><I>provided, however,</I> that paragraphs
(a)(1)(i) and (a)(1)(ii) do not apply if the information required to be included in a post-effective amendment by those paragraphs
is contained in periodic reports filed with or furnished to the Commission by the registrant pursuant to Section 13 or Section
15(d) of the Exchange Act that are incorporated by reference in this Registration Statement.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.5in">(2) That, for the purpose
of determining any liability under the Securities Act, each such post-effective amendment shall be deemed to be a new registration
statement relating to the securities offered therein, and the offering of such securities at that time shall be deemed to be the
initial <I>bona fide</I> offering thereof.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.5in">(3) To remove from
registration by means of a post-effective amendment any of the securities being registered which remain unsold at the termination
of the offering.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">(b)&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;The undersigned registrant hereby
undertakes that, for purposes of determining any liability under the Securities Act, each filing of the registrant&rsquo;s annual
report pursuant to Section 13(a) or Section 15(d) of the Exchange Act (and, where applicable, each filing of an employee benefit
plan&rsquo;s annual report pursuant to section 15(d) of the Exchange Act) that is incorporated by reference in this Registration
Statement shall be deemed to be a new registration statement relating to the securities offered therein, and the offering of such
securities at that time shall be deemed to be the initial <I>bona fide</I> offering thereof.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">(h)&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Insofar as indemnification for
liabilities arising under the Securities Act may be permitted to directors, officers and controlling persons of the registrant
pursuant to the foregoing provisions, or otherwise, the registrant has been advised that in the opinion of the Securities and Exchange
Commission such indemnification is against public policy as expressed in the Securities Act and is, therefore, unenforceable. In
the event that a claim for indemnification against such liabilities (other than the payment by the registrant of expenses incurred
or paid by a director, officer or controlling person of the registrant in the successful defense of any action, suit or proceeding)
is asserted by such director, officer or controlling person in connection with the securities being registered, the registrant
will, unless in the opinion of its counsel the matter has been settled by controlling precedent, submit to a court of appropriate
jurisdiction the question whether such indemnification by it is against public policy as expressed in the Securities Act and will
be governed by the final adjudication of such issue.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>


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    <DIV STYLE="page-break-before: always; margin-top: 6pt; margin-bottom: 12pt"><P STYLE="margin: 0pt">&nbsp;</P></DIV>
    <!-- Field: /Page -->

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>SIGNATURES</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.5in">Pursuant to the requirements
of the Securities Act of 1933, as amended, the Company certifies that it has reasonable grounds to believe that it meets all of
the requirements for filing on Form S-8 and has duly caused this Registration Statement to be signed on its behalf by the undersigned,
thereunto duly authorized, thereto duly authorized, in the City of Los Angeles, State of California, on October 30, 2015.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 90%; border-collapse: collapse">
<tr style="vertical-align: top">
    <TD>&nbsp;</td>
    <td colspan="2"><font style="font-size: 10pt"><b>RITTER PHARMACEUTICALS, INC.</b></font></td></tr>
<tr style="vertical-align: top">
    <TD>&nbsp;</td>
    <td colspan="2">&nbsp;</td></tr>
<tr style="vertical-align: top">
    <TD STYLE="width: 60%">&nbsp;</td>
    <TD STYLE="width: 5%"><font style="font-size: 10pt">By:</font></td>
    <TD STYLE="width: 35%; border-bottom: Black 1pt solid"><font style="font-size: 10pt">/s/ Michael D. Step</font></td></tr>
<tr style="vertical-align: top">
    <TD>&nbsp;</td>
    <TD>&nbsp;</td>
    <TD><font style="font-size: 10pt">Michael D. Step</font></td></tr>
<tr style="vertical-align: top">
    <TD>&nbsp;</td>
    <TD>&nbsp;</td>
    <TD><font style="font-size: 10pt">Chief Executive Officer</font></td></tr>
</table>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>&nbsp;</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>POWER OF ATTORNEY</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 6pt; text-indent: 16pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.5in">KNOW ALL MEN BY THESE
PRESENTS that each of the undersigned directors and officers of Ritter Pharmaceuticals, Inc. hereby appoints Michael D. Step as
his true and lawful attorney-in-fact and agent, for him and in his name, place and stead, with full power to act alone, to sign
on his behalf and in the capacity set forth below, any and all amendments and post-effective amendments and supplements to this
Registration Statement on Form S-8 and to file each such amendment and post-effective amendment and supplements to this Registration
Statement, with all exhibits thereto, and any and all other documents in connection therewith, with the Securities and Exchange
Commission, hereby granting unto said attorney-in-fact and agent full power and authority to do and perform any and all acts and
things requisite and necessary or appropriate to be done in and about the premises as fully to all intents and purposes as he might
or could do in person, hereby ratifying and confirming all that said attorney-in-fact and agent may lawfully do or cause to be
done by virtue hereof.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 3pt; text-align: justify; text-indent: 16pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.5in">Pursuant to the requirements
of the Securities Act of 1933, as amended, this Registration Statement has been signed by the following persons in the capacities
and on the dates indicated.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
<tr style="vertical-align: top">
    <TD STYLE="width: 30%; text-align: center"><font style="font-size: 10pt">Signature</font></td>
    <TD STYLE="width: 2%; text-align: center">&nbsp;</td>
    <TD STYLE="width: 48%; text-align: center"><font style="font-size: 10pt">Title</font></td>
    <TD STYLE="width: 2%; text-align: center">&nbsp;</td>
    <TD STYLE="width: 18%; text-align: center"><font style="font-size: 10pt">Date</font></td></tr>
<tr style="vertical-align: top">
    <TD STYLE="text-align: center">&nbsp;</td>
    <TD STYLE="text-align: center">&nbsp;</td>
    <TD STYLE="text-align: center">&nbsp;</td>
    <TD STYLE="text-align: center">&nbsp;</td>
    <TD STYLE="text-align: center">&nbsp;</td></tr>
<tr>
    <TD STYLE="vertical-align: bottom; border-bottom: Black 1pt solid; text-align: center"><font style="font-size: 10pt">/s/ Michael D. Step</font></td>
    <TD STYLE="vertical-align: top; text-align: center">&nbsp;</td>
    <TD STYLE="vertical-align: top">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">Chief Executive Officer and Director</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">(<i>Principal Executive Officer</i>)</P></td>
    <TD STYLE="vertical-align: top; text-align: center">&nbsp;</td>
    <TD STYLE="vertical-align: top; text-align: center"><font style="font-size: 10pt">October 30, 2015</font></td></tr>
<tr>
    <TD STYLE="vertical-align: bottom; text-align: center"><font style="font-size: 10pt">Michael D. Step</font></td>
    <TD STYLE="vertical-align: top; text-align: center">&nbsp;</td>
    <TD STYLE="vertical-align: top; text-align: center">&nbsp;</td>
    <TD STYLE="vertical-align: top; text-align: center">&nbsp;</td>
    <TD STYLE="vertical-align: top; text-align: center">&nbsp;</td></tr>
<tr>
    <TD STYLE="vertical-align: bottom; text-align: center">&nbsp;</td>
    <TD STYLE="vertical-align: top; text-align: center">&nbsp;</td>
    <TD STYLE="vertical-align: top; text-align: center">&nbsp;</td>
    <TD STYLE="vertical-align: top; text-align: center">&nbsp;</td>
    <TD STYLE="vertical-align: top; text-align: center">&nbsp;</td></tr>
<tr>
    <TD STYLE="vertical-align: bottom; border-bottom: Black 1pt solid; text-align: center"><font style="font-size: 10pt">/s/ Ellen Mochizuki</font></td>
    <TD STYLE="vertical-align: top; text-align: center">&nbsp;</td>
    <TD STYLE="vertical-align: top">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">Vice President, Finance</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">(<i>Principal Financial and Accounting Officer</i>)</P></td>
    <TD STYLE="vertical-align: top; text-align: center">&nbsp;</td>
    <TD STYLE="vertical-align: top; text-align: center"><font style="font-size: 10pt">October 30, 2015</font></td></tr>
<tr>
    <TD STYLE="vertical-align: bottom; text-align: center"><font style="font-size: 10pt">Ellen Mochizuki</font></td>
    <TD STYLE="vertical-align: top; text-align: center">&nbsp;</td>
    <TD STYLE="vertical-align: top; text-align: center">&nbsp;</td>
    <TD STYLE="vertical-align: top; text-align: center">&nbsp;</td>
    <TD STYLE="vertical-align: top; text-align: center">&nbsp;</td></tr>
<tr>
    <TD STYLE="vertical-align: bottom; text-align: center">&nbsp;</td>
    <TD STYLE="vertical-align: top; text-align: center">&nbsp;</td>
    <TD STYLE="vertical-align: top; text-align: center">&nbsp;</td>
    <TD STYLE="vertical-align: top; text-align: center">&nbsp;</td>
    <TD STYLE="vertical-align: top; text-align: center">&nbsp;</td></tr>
<tr>
    <TD STYLE="vertical-align: bottom; border-bottom: Black 1pt solid; text-align: center"><font style="font-size: 10pt">/s/ Ira E. Ritter</font></td>
    <TD STYLE="vertical-align: top; text-align: center">&nbsp;</td>
    <TD STYLE="vertical-align: top; text-align: center"><font style="font-size: 10pt">Executive Chairman, Chief Strategic Officer and Director</font></td>
    <TD STYLE="vertical-align: top; text-align: center">&nbsp;</td>
    <TD STYLE="vertical-align: top; text-align: center"><font style="font-size: 10pt">October 30, 2015</font></td></tr>
<tr>
    <TD STYLE="vertical-align: bottom; text-align: center"><font style="font-size: 10pt">Ira E. Ritter</font></td>
    <TD STYLE="vertical-align: top; text-align: center">&nbsp;</td>
    <TD STYLE="vertical-align: top; text-align: center">&nbsp;</td>
    <TD STYLE="vertical-align: top; text-align: center">&nbsp;</td>
    <TD STYLE="vertical-align: top; text-align: center">&nbsp;</td></tr>
<tr>
    <TD STYLE="vertical-align: bottom; text-align: center">&nbsp;</td>
    <TD STYLE="vertical-align: top; text-align: center">&nbsp;</td>
    <TD STYLE="vertical-align: top; text-align: center">&nbsp;</td>
    <TD STYLE="vertical-align: top; text-align: center">&nbsp;</td>
    <TD STYLE="vertical-align: top; text-align: center">&nbsp;</td></tr>
<tr>
    <TD STYLE="vertical-align: bottom; border-bottom: Black 1pt solid; text-align: center"><font style="font-size: 10pt">/s/ Andrew J. Ritter</font></td>
    <TD STYLE="vertical-align: top; text-align: center">&nbsp;</td>
    <TD STYLE="vertical-align: top; text-align: center"><font style="font-size: 10pt">President and Director</font></td>
    <TD STYLE="vertical-align: top; text-align: center">&nbsp;</td>
    <TD STYLE="vertical-align: top; text-align: center"><font style="font-size: 10pt">October 30, 2015</font></td></tr>
<tr>
    <TD STYLE="vertical-align: bottom; text-align: center"><font style="font-size: 10pt">Andrew J. Ritter</font></td>
    <TD STYLE="vertical-align: top; text-align: center">&nbsp;</td>
    <TD STYLE="vertical-align: top; text-align: center">&nbsp;</td>
    <TD STYLE="vertical-align: top; text-align: center">&nbsp;</td>
    <TD STYLE="vertical-align: top; text-align: center">&nbsp;</td></tr>
<tr>
    <TD STYLE="vertical-align: bottom; text-align: center">&nbsp;</td>
    <TD STYLE="vertical-align: top; text-align: center">&nbsp;</td>
    <TD STYLE="vertical-align: top; text-align: center">&nbsp;</td>
    <TD STYLE="vertical-align: top; text-align: center">&nbsp;</td>
    <TD STYLE="vertical-align: top; text-align: center">&nbsp;</td></tr>
<tr>
    <TD STYLE="vertical-align: bottom; border-bottom: Black 1pt solid; text-align: center"><font style="font-size: 10pt">/s/ Noah Doyle</font></td>
    <TD STYLE="vertical-align: top; text-align: center">&nbsp;</td>
    <TD STYLE="vertical-align: top; text-align: center"><font style="font-size: 10pt">Director</font></td>
    <TD STYLE="vertical-align: top; text-align: center">&nbsp;</td>
    <TD STYLE="vertical-align: top; text-align: center"><font style="font-size: 10pt">October 30, 2015</font></td></tr>
<tr>
    <TD STYLE="vertical-align: bottom; text-align: center"><font style="font-size: 10pt">Noah Doyle</font></td>
    <TD STYLE="vertical-align: top; text-align: center">&nbsp;</td>
    <TD STYLE="vertical-align: top; text-align: center">&nbsp;</td>
    <TD STYLE="vertical-align: top; text-align: center">&nbsp;</td>
    <TD STYLE="vertical-align: top; text-align: center">&nbsp;</td></tr>
<tr>
    <TD STYLE="vertical-align: bottom; text-align: center">&nbsp;</td>
    <TD STYLE="vertical-align: top; text-align: center">&nbsp;</td>
    <TD STYLE="vertical-align: top; text-align: center">&nbsp;</td>
    <TD STYLE="vertical-align: top; text-align: center">&nbsp;</td>
    <TD STYLE="vertical-align: top; text-align: center">&nbsp;</td></tr>
<tr>
    <TD STYLE="vertical-align: bottom; border-bottom: Black 1pt solid; text-align: center"><font style="font-size: 10pt">/s/ Matthew W. Foehr</font></td>
    <TD STYLE="vertical-align: top; text-align: center">&nbsp;</td>
    <TD STYLE="vertical-align: top; text-align: center"><font style="font-size: 10pt">Director</font></td>
    <TD STYLE="vertical-align: top; text-align: center">&nbsp;</td>
    <TD STYLE="vertical-align: top; text-align: center"><font style="font-size: 10pt">October 30, 2015</font></td></tr>
<tr>
    <TD STYLE="vertical-align: bottom; text-align: center"><font style="font-size: 10pt">Matthew W. Foehr</font></td>
    <TD STYLE="vertical-align: top; text-align: center">&nbsp;</td>
    <TD STYLE="vertical-align: top; text-align: center">&nbsp;</td>
    <TD STYLE="vertical-align: top; text-align: center">&nbsp;</td>
    <TD STYLE="vertical-align: top; text-align: center">&nbsp;</td></tr>
<tr>
    <TD STYLE="vertical-align: bottom; text-align: center">&nbsp;</td>
    <TD STYLE="vertical-align: top; text-align: center">&nbsp;</td>
    <TD STYLE="vertical-align: top; text-align: center">&nbsp;</td>
    <TD STYLE="vertical-align: top; text-align: center">&nbsp;</td>
    <TD STYLE="vertical-align: top; text-align: center">&nbsp;</td></tr>
<tr>
    <TD STYLE="vertical-align: bottom; border-bottom: Black 1pt solid; text-align: center"><font style="font-size: 10pt">/s/ Paul V. Maier</font></td>
    <TD STYLE="vertical-align: top; text-align: center">&nbsp;</td>
    <TD STYLE="vertical-align: top; text-align: center"><font style="font-size: 10pt">Director</font></td>
    <TD STYLE="vertical-align: top; text-align: center">&nbsp;</td>
    <TD STYLE="vertical-align: top; text-align: center"><font style="font-size: 10pt">October 30, 2015</font></td></tr>
<tr>
    <TD STYLE="vertical-align: bottom; text-align: center"><font style="font-size: 10pt">Paul V. Maier</font></td>
    <TD STYLE="vertical-align: top; text-align: center">&nbsp;</td>
    <TD STYLE="vertical-align: top; text-align: center">&nbsp;</td>
    <TD STYLE="vertical-align: top; text-align: center">&nbsp;</td>
    <TD STYLE="vertical-align: top; text-align: center">&nbsp;</td></tr>
<tr>
    <TD STYLE="vertical-align: bottom; text-align: center">&nbsp;</td>
    <TD STYLE="vertical-align: top; text-align: center">&nbsp;</td>
    <TD STYLE="vertical-align: top; text-align: center">&nbsp;</td>
    <TD STYLE="vertical-align: top; text-align: center">&nbsp;</td>
    <TD STYLE="vertical-align: top; text-align: center">&nbsp;</td></tr>
<tr>
    <TD STYLE="vertical-align: bottom; border-bottom: Black 1pt solid; text-align: center"><font style="font-size: 10pt">/s/ Gerald T. Proehl</font></td>
    <TD STYLE="vertical-align: top; text-align: center">&nbsp;</td>
    <TD STYLE="vertical-align: top; text-align: center"><font style="font-size: 10pt">Director</font></td>
    <TD STYLE="vertical-align: top; text-align: center">&nbsp;</td>
    <TD STYLE="vertical-align: top; text-align: center"><font style="font-size: 10pt">October 30, 2015</font></td></tr>
<tr>
    <TD STYLE="vertical-align: bottom; text-align: center"><font style="font-size: 10pt">Gerald T. Proehl</font></td>
    <TD STYLE="vertical-align: top; text-align: center">&nbsp;</td>
    <TD STYLE="vertical-align: top; text-align: center">&nbsp;</td>
    <TD STYLE="vertical-align: top; text-align: center">&nbsp;</td>
    <TD STYLE="vertical-align: top; text-align: center">&nbsp;</td></tr>
</table>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>&nbsp;</B></P>


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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B>&nbsp;</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>INDEX TO EXHIBITS</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%">
<tr>
    <TD STYLE="vertical-align: bottom; width: 10%; border-bottom: Black 1pt solid"><font style="font-size: 10pt"><b>Exhibit&nbsp;No.</b></font></td>
    <TD STYLE="vertical-align: top; width: 2%; padding-bottom: 1pt">&nbsp;</td>
    <TD STYLE="vertical-align: bottom; width: 88%; border-bottom: Black 1pt solid"><font style="font-size: 10pt"><b>Description of Exhibit</b></font></td></tr>
<tr style="vertical-align: top">
    <TD STYLE="text-align: center"><font style="font-size: 10pt">5.1</font></td>
    <TD STYLE="padding-left: 12.25pt; text-indent: -12.25pt">&nbsp;</td>
    <TD STYLE="padding-left: 12.25pt; text-indent: -12.25pt"><font style="font-size: 10pt">Opinion of Reed Smith LLP*</font></td></tr>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: center">&nbsp;</TD>
    <TD STYLE="padding-left: 12.25pt; text-indent: -12.25pt">&nbsp;</TD>
    <TD STYLE="padding-left: 12.25pt; text-indent: -12.25pt">&nbsp;</TD></TR>
<tr style="vertical-align: top">
    <TD STYLE="text-align: center"><font style="font-size: 10pt">23.1</font></td>
    <TD>&nbsp;</td>
    <TD><FONT STYLE="font-size: 10pt">Consent of Mayer Hoffman McCann P.C., independent registered public
    accounting firm*</FONT></td></tr>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: center">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<tr style="vertical-align: top">
    <TD STYLE="text-align: center"><font style="font-size: 10pt">23.2</font></td>
    <TD STYLE="padding-left: 12.25pt; text-indent: -12.25pt">&nbsp;</td>
    <TD STYLE="padding-left: 12.25pt; text-indent: -12.25pt"><font style="font-size: 10pt">Consent of Reed Smith LLP (contained in Exhibit 5.1 to this Registration Statement)*</font></td></tr>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: center">&nbsp;</TD>
    <TD STYLE="padding-left: 12.25pt; text-indent: -12.25pt">&nbsp;</TD>
    <TD STYLE="padding-left: 12.25pt; text-indent: -12.25pt">&nbsp;</TD></TR>
<tr style="vertical-align: top">
    <TD STYLE="text-align: center"><font style="font-size: 10pt">24.1</font></td>
    <TD>&nbsp;</td>
    <TD><font style="font-size: 10pt">Power of Attorney of certain Officers and Directors of the Company (contained on signature page to this Registration Statement)*</font></td></tr>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: center">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<tr style="vertical-align: top">
    <TD STYLE="text-align: center"><font style="font-size: 10pt">99.1</font></td>
    <TD>&nbsp;</td>
    <TD><font style="font-size: 10pt">Ritter Pharmaceuticals, Inc. 2008 Stock Plan*</font></td></tr>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: center">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<tr style="vertical-align: top">
    <TD STYLE="text-align: center"><font style="font-size: 10pt">99.2</font></td>
    <TD>&nbsp;</td>
    <TD><font style="font-size: 10pt">Ritter Pharmaceuticals, Inc. 2009 Stock Plan (incorporated herein by reference to Exhibit 10.6&nbsp;&nbsp;to the Company&rsquo;s Registration Statement on Form S-1 (File No. 333-202924) filed March 23, 2015)</font></td></tr>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: center">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<tr style="vertical-align: top">
    <TD STYLE="text-align: center"><font style="font-size: 10pt">99.3</font></td>
    <TD>&nbsp;</td>
    <TD><font style="font-size: 10pt">Ritter Pharmaceuticals, Inc. 2015 Equity Incentive Plan*</font></td></tr>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: center">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<tr style="vertical-align: top">
    <TD STYLE="text-align: center"><font style="font-size: 10pt">99.4</font></td>
    <TD>&nbsp;</td>
    <TD><font style="font-size: 10pt">Form of Stock Option Agreement under the Ritter Pharmaceuticals, Inc. 2015 Equity Incentive Plan*</font></td></tr>
</table>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 13.5pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">*Filed herewith</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>


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[{"type": "S-8", "sequence": "1", "filename": "t1502497_s8.htm", "description": "FORM S-8", "secsgml_size_bytes": 66931}]
{"company-data": {"conformed-name": "RITTER PHARMACEUTICALS INC", "cik": "0001460702", "assigned-sic": "2834", "irs-number": "263474527", "state-of-incorporation": "DE", "fiscal-year-end": "1231"}, "filing-values": {"form-type": "S-8", "act": "33", "file-number": "333-207709", "film-number": "151188493"}, "business-address": {"street1": "1880 CENTURY PARK EAST, SUITE 1000", "city": "LOS ANGELES", "state": "CA", "zip": "90067", "phone": "310-203-1000"}, "mail-address": {"street1": "1880 CENTURY PARK EAST, SUITE 1000", "city": "LOS ANGELES", "state": "CA", "zip": "90067"}}
As filed with the Securities and Exchange
Commission on October 30, 2015
Registration No. 333-
UNITED STATES
SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM S-8
REGISTRATION STATEMENT
UNDER
THE
SECURITIES ACT OF 1933
RITTER PHARMACEUTICALS, INC.
(Exact name of registrant as specified in
its charter)
Delaware
20-1295171
(State or other jurisdiction of
(I.R.S. Employer
incorporation or organization)
Identification Number)
Ritter Pharmaceuticals, Inc.
1880 Century Park East, Suite 1000
Los Angeles, CA 90067
(310) 203-1000
(Address of Principal Executive Offices)
RITTER PHARMACEUTICALS, INC. 2008 STOCK
PLAN
RITTER PHARMACEUTICALS, INC. 2009 STOCK
PLAN
RITTER PHARMACEUTICALS, INC. 2015 EQUITY
INCENTIVE PLAN
(Full title of the plans)
Michael D. Step
Chief Executive Officer
Ritter Pharmaceuticals, Inc.
1880 Century Park East, Suite 1000
Los Angeles, CA 90067
(310) 203-1000
(Name, address and telephone number (including
area code) of agent for service)
Copy to:
Michael Sanders, Esq.
David Mittelman, Esq.
Deborah Gunny, Esq.
Reed Smith LLP
1901 Avenue of the Stars
Suite 700
Los Angeles, CA 90067-6708
(310) 734-5200
(310) 734-5299 Facsimile
Indicate by check mark whether the registrant is a large accelerated
filer, an accelerated filer, a non-accelerated filer or a smaller reporting company. See definitions of "large accelerated
filer," "accelerated filer" and "smaller reporting company" in Rule 12b-2 of the Exchange Act (check
one):
Large accelerated filer
¨
Accelerated filer
¨
Non-accelerated filer
¨
(Do not check if a smaller reporting company)
Smaller reporting company
x
CALCULATION OF REGISTRATION FEE
Title of Securities to be
registered
Amount to be
registered
(1)
Proposed maximum
offering
price per share
Proposed maximum
aggregate
offering price
Amount of registration
fee
Common Stock, $0.001 par value per share
1,886,633 shares
(2)
$7.228
(3)
$13,636,583.32
$1,373.20
Common Stock, $0.001 par value per share
18,601 shares
(4)
$0.715
(5)
$13,299.72
$1.34
Common Stock, $0.001 par value per share
2,111,682 shares
(6)
$2.23
(7)
$4,709,050.86
$474.20
(1) Pursuant to Rule 416(a) under the Securities
Act of 1933, as amended (the "Securities Act"), this Registration Statement also covers an indeterminate number of
additional shares of common stock, par value $0.001 per share (the "Common Stock") of Ritter Pharmaceuticals, Inc.
(the "Company") that may be offered or sold under the Ritter Pharmaceuticals, Inc. 2008 Stock Plan (the "2008
Plan"), the Ritter Pharmaceuticals, Inc. 2009 Stock Plan (the "2009 Plan"), and the Ritter Pharmaceuticals, Inc. 2015
Equity Incentive Plan (the "2015 Plan") by reason of any substitutions or adjustments to shares to account for any
change in capitalization, including any stock dividend, stock split, reverse stock split, split up, spin-off, recapitalization,
or other distribution of stock or property of the Company, combination or exchange of shares or common stock, dividend in kind,
or other like change in capital structure.
(2) Represents shares of Common Stock subject
to stock options presently outstanding under the 2008 Plan. To the extent such awards are forfeited or lapse unexercised or are
settled in cash and are not issued under the 2008 Plan, the Common Stock subject to such awards will be available for future issuance
under the 2015 Plan.
(3) Estimated in accordance with Rule 457(h)
of the Securities Act solely for the purpose of calculating the registration fee on the basis of the weighted average exercise
price of $7.085 per share for outstanding stock options granted under the 2008 Plan.
(4) Represents shares of Common Stock subject
to stock options presently outstanding under the 2009 Plan. To the extent such awards are forfeited or lapse unexercised or are
settled in cash and are not issued under the 2009 Plan, the Common Stock subject to such awards will be available for future issuance
under the 2015 Plan.
(5) Estimated in accordance with Rule 457(h)
of the Securities Act solely for the purpose of calculating the registration fee on the basis of the weighted average exercise
price of $0.72 per share for outstanding stock options granted under the 2009 Plan.
(6) Represents shares of Common Stock
available for future issuance under the 2015 Plan, which number consists of (a) 206,448 shares of Common Stock presently
available for issuance under the 2015 Plan and (b) up to an additional 1,905,234 shares of Common Stock that may become issuable
under the 2015 Plan pursuant to its terms to the extent presently outstanding awards under the 2008 Plan and 2009 Plan are forfeited
or lapse unexercised or are settled in cash. The additional 1,905,234 shares of Common Stock represent the aggregate of 1,886,633
shares under the 2008 Plan corresponding to footnote (2) and the 18,601 shares under the 2009 Plan corresponding to footnote (4)
of this Calculation of Registration Fee table.
(7) Estimated in accordance with Rule 457(h)
of the Securities Act solely for the purpose of calculating the registration fee. In accordance with Rule 457(c) of the Securities
Act, the offering price per share are based upon the average of the high and low prices, which were $2.15 and $2.31, for the Common
Stock of the Company as reported on the NASDAQ Stock Market on October 27, 2015.
PART I
INFORMATION REQUIRED IN THE SECTION 10(a)
PROSPECTUS
The information required
by Part I is included in one or more documents to be sent or given to participants in the 2008 Plan, the 2009 Plan, and the 2015
Plan pursuant to Rule 428 under the Securities Act. In accordance with the rules and regulations of the Securities and Exchange
Commission (the "Commission"), and the instructions to Form S-8, such documents are not being filed with the Commission
either as a part of this Registration Statement or as prospectuses or prospectus supplements pursuant to Rule 424 under the Securities
Act.
PART II
INFORMATION REQUIRED IN THE REGISTRATION
STATEMENT
Item 3. Incorporation of Documents by Reference.
The following documents
previously filed with the Commission are hereby incorporated by reference into this Registration Statement:
(a)
the
Company's prospectus filed on June 26, 2015 pursuant to Rule 424(b) of the Securities Act relating to the Company's
Registration Statement on Form S-1 (File No. 333-202924) that contains audited financial statements of the Company for the latest
fiscal year for which such statements have been filed;
(b)   the Company's quarterly
report on Form 10-Q for the fiscal period ended June 30, 2015 filed on August 12, 2015;
(c)   the Company's current
reports on Form 8-K filed on July 1, 2015, July 14, 2015, July 27, 2015, September 22, 2015, and October 26, 2015; and
(d)   the description of the
Company's Common Stock contained in the Company' Registration Statement on Form 8-A (File No. 1-37428) filed on June
15, 2015, including any amendment or report filed for the purpose of updating such description.
In addition, all documents
that the Company files pursuant to Sections 13(a), 13(c), 14 and 15(d) of the Exchange Act of 1934, as amended (the "Exchange
Act"), subsequent to the filing of this Registration Statement and prior to the filing of a post-effective amendment which
indicates that all securities offered hereby have been sold or which deregisters all securities then remaining unsold, shall be
deemed to be incorporated by reference into this Registration Statement and to be a part hereof from the date of filing of such
documents, except as to any document or portion of any document that is deemed furnished and not filed.
Pursuant to Rule 412
under the Securities Act, any statement contained in the documents incorporated or deemed to be incorporated by reference in this
Registration Statement shall be deemed to be modified, superseded or replaced for purposes of this Registration Statement to the
extent that a statement contained herein or in any other subsequently filed document which also is incorporated or deemed to be
incorporated by reference in this Registration Statement modifies, supersedes or replaces such statement. Any such statement so
modified, superseded or replaced shall not be deemed, except as so modified, superseded or replaced, to constitute a part of this
Registration Statement.
Item 4.
Description of Securities.
Not applicable.
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Item 5.
Interests of Named Experts and Counsel.
Not applicable.
Item 6.
Indemnification of Directors and Officers.
The Company's
restated certificate of incorporation provides that the Company shall indemnify, to the fullest extent authorized by the Delaware
General Corporation Law, each person who is involved in any litigation or other proceeding because such person is or was a director
or officer of the Company or is or was serving as an officer or director of another entity at the Company's request, against
all expense, loss or liability reasonably incurred or suffered in connection therewith. The Company's certificate of incorporation
provides that the right to indemnification includes the right to be paid expenses incurred in defending any proceeding in advance
of its final disposition, provided, however, that such advance payment will only be made upon delivery to us of an undertaking,
by or on behalf of the director or officer, to repay all amounts so advanced if it is ultimately determined that such director
is not entitled to indemnification. If the Company does not pay a proper claim for indemnification in full within 30 days after
receiving a written claim for such indemnification, the Company's certificate of incorporation and bylaws authorize the claimant
to bring an action against the Company and prescribe what constitutes a defense to such action.
Section 145 of the
Delaware General Corporation Law permits a corporation to indemnify any director or officer of the corporation against expenses
(including attorney's fees), judgments, fines and amounts paid in settlement actually and reasonably incurred in connection
with any action, suit or proceeding brought by reason of the fact that such person is or was a director or officer of the corporation,
if such person acted in good faith and in a manner that he reasonably believed to be in, or not opposed to, the best interests
of the corporation, and, with respect to any criminal action or proceeding, if he or she had no reason to believe his or her conduct
was unlawful. In a derivative action, (i.e., one brought by or on behalf of the corporation), indemnification may be provided only
for expenses actually and reasonably incurred by any director or officer in connection with the defense or settlement of such an
action or suit if such person acted in good faith and in a manner that he or she reasonably believed to be in, or not opposed to,
the best interests of the corporation, except that no indemnification shall be provided if such person shall have been adjudged
to be liable to the corporation, unless and only to the extent that the court in which the action or suit was brought shall determine
that the defendant is fairly and reasonably entitled to indemnity for such expenses despite such adjudication of liability.
Pursuant to Section
102(b)(7) of the Delaware General Corporation Law, the Company's certificate of incorporation eliminates the liability of
a director to the Company or its stockholders for monetary damages for such a breach of fiduciary duty as a director, except for
liabilities arising:
•
from any breach of the director's duty of loyalty
to the Company or its stockholders;
•
from acts or omissions not in good faith or which involve intentional misconduct or a knowing violation
of law;
•
under Section 174 of the Delaware General Corporation Law;
or
•
from any transaction from which the director derived an
improper personal benefit.
The Company carries
insurance policies insuring the Company's directors and officers against certain liabilities that they may incur in their
capacity as directors and officers.
In addition, the Company
has entered into indemnification agreements with each of the Company's current directors and executive officers. These agreements
require the Company to indemnify these individuals to the fullest extent permitted under Delaware law against liabilities that
may arise by reason of their service to the Company and to advance expenses incurred as a result of any proceeding against them
as to which they could be indemnified. The Company also intends to enter into indemnification agreements with future directors
and executive officers of the Company.
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Item 7.
Exemption from Registration Claimed.
Not applicable.
Item 8.
Exhibits.
The Exhibit Index immediately preceding
the exhibits is incorporated in this Item 8 by reference.
Item 9.
Undertakings.
(a)
The undersigned registrant hereby undertakes:
(1) To file, during
any period in which offers or sales are being made, a post-effective amendment to this Registration Statement:
(i) To include
any prospectus required by Section 10(a)(3) of the Securities Act;
(ii) To reflect
in the prospectus any facts or events arising after the effective date of the Registration Statement (or the most recent post-effective
amendment thereof) which, individually or in the aggregate, represent a fundamental change in the information set forth in this
Registration Statement; and
(iii) To
include any material information with respect to the plan of distribution not previously disclosed in this Registration Statement
or any material change to such information in this Registration Statement;
provided, however,
that paragraphs
(a)(1)(i) and (a)(1)(ii) do not apply if the information required to be included in a post-effective amendment by those paragraphs
is contained in periodic reports filed with or furnished to the Commission by the registrant pursuant to Section 13 or Section
15(d) of the Exchange Act that are incorporated by reference in this Registration Statement.
(2) That, for the purpose
of determining any liability under the Securities Act, each such post-effective amendment shall be deemed to be a new registration
statement relating to the securities offered therein, and the offering of such securities at that time shall be deemed to be the
initial
bona fide
offering thereof.
(3) To remove from
registration by means of a post-effective amendment any of the securities being registered which remain unsold at the termination
of the offering.
(b)          The undersigned registrant hereby
undertakes that, for purposes of determining any liability under the Securities Act, each filing of the registrant's annual
report pursuant to Section 13(a) or Section 15(d) of the Exchange Act (and, where applicable, each filing of an employee benefit
plan's annual report pursuant to section 15(d) of the Exchange Act) that is incorporated by reference in this Registration
Statement shall be deemed to be a new registration statement relating to the securities offered therein, and the offering of such
securities at that time shall be deemed to be the initial
bona fide
offering thereof.
(h)          Insofar as indemnification for
liabilities arising under the Securities Act may be permitted to directors, officers and controlling persons of the registrant
pursuant to the foregoing provisions, or otherwise, the registrant has been advised that in the opinion of the Securities and Exchange
Commission such indemnification is against public policy as expressed in the Securities Act and is, therefore, unenforceable. In
the event that a claim for indemnification against such liabilities (other than the payment by the registrant of expenses incurred
or paid by a director, officer or controlling person of the registrant in the successful defense of any action, suit or proceeding)
is asserted by such director, officer or controlling person in connection with the securities being registered, the registrant
will, unless in the opinion of its counsel the matter has been settled by controlling precedent, submit to a court of appropriate
jurisdiction the question whether such indemnification by it is against public policy as expressed in the Securities Act and will
be governed by the final adjudication of such issue.
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SIGNATURES
Pursuant to the requirements
of the Securities Act of 1933, as amended, the Company certifies that it has reasonable grounds to believe that it meets all of
the requirements for filing on Form S-8 and has duly caused this Registration Statement to be signed on its behalf by the undersigned,
thereunto duly authorized, thereto duly authorized, in the City of Los Angeles, State of California, on October 30, 2015.
RITTER PHARMACEUTICALS, INC.
By:
/s/ Michael D. Step
Michael D. Step
Chief Executive Officer
POWER OF ATTORNEY
KNOW ALL MEN BY THESE
PRESENTS that each of the undersigned directors and officers of Ritter Pharmaceuticals, Inc. hereby appoints Michael D. Step as
his true and lawful attorney-in-fact and agent, for him and in his name, place and stead, with full power to act alone, to sign
on his behalf and in the capacity set forth below, any and all amendments and post-effective amendments and supplements to this
Registration Statement on Form S-8 and to file each such amendment and post-effective amendment and supplements to this Registration
Statement, with all exhibits thereto, and any and all other documents in connection therewith, with the Securities and Exchange
Commission, hereby granting unto said attorney-in-fact and agent full power and authority to do and perform any and all acts and
things requisite and necessary or appropriate to be done in and about the premises as fully to all intents and purposes as he might
or could do in person, hereby ratifying and confirming all that said attorney-in-fact and agent may lawfully do or cause to be
done by virtue hereof.
Pursuant to the requirements
of the Securities Act of 1933, as amended, this Registration Statement has been signed by the following persons in the capacities
and on the dates indicated.
Signature
Title
Date
/s/ Michael D. Step
Chief Executive Officer and Director
(
Principal Executive Officer
)
October 30, 2015
Michael D. Step
/s/ Ellen Mochizuki
Vice President, Finance
(
Principal Financial and Accounting Officer
)
October 30, 2015
Ellen Mochizuki
/s/ Ira E. Ritter
Executive Chairman, Chief Strategic Officer and Director
October 30, 2015
Ira E. Ritter
/s/ Andrew J. Ritter
President and Director
October 30, 2015
Andrew J. Ritter
/s/ Noah Doyle
Director
October 30, 2015
Noah Doyle
/s/ Matthew W. Foehr
Director
October 30, 2015
Matthew W. Foehr
/s/ Paul V. Maier
Director
October 30, 2015
Paul V. Maier
/s/ Gerald T. Proehl
Director
October 30, 2015
Gerald T. Proehl
INDEX TO EXHIBITS
Exhibit No.
Description of Exhibit
5.1
Opinion of Reed Smith LLP*
23.1
Consent of Mayer Hoffman McCann P.C., independent registered public
    accounting firm*
23.2
Consent of Reed Smith LLP (contained in Exhibit 5.1 to this Registration Statement)*
24.1
Power of Attorney of certain Officers and Directors of the Company (contained on signature page to this Registration Statement)*
99.1
Ritter Pharmaceuticals, Inc. 2008 Stock Plan*
99.2
Ritter Pharmaceuticals, Inc. 2009 Stock Plan (incorporated herein by reference to Exhibit 10.6  to the Company's Registration Statement on Form S-1 (File No. 333-202924) filed March 23, 2015)
99.3
Ritter Pharmaceuticals, Inc. 2015 Equity Incentive Plan*
99.4
Form of Stock Option Agreement under the Ritter Pharmaceuticals, Inc. 2015 Equity Incentive Plan*
*Filed herewith