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<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px"><font style="font-weight: bold; font-size: 13px; font-family: Times New Roman">As
filed with the Securities and Exchange Commission on November 12,
2020<font style="background-color: #ffff00"><br></font></font></div>
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px"><font style="font-weight: bold; font-size: 13px; font-family: Times New Roman">Registration
No.&#xA0;333-&#xA0;&#xA0;&#xA0;&#xA0;&#xA0;&#xA0;&#xA0;&#xA0;&#xA0;&#xA0;&#xA0;</font></div>
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px"><font style="font-size: 1px; font-family: Times New Roman">&#xA0;</font></div>
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<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px"><font style="font-weight: bold; font-size: 24px; font-family: Times New Roman">UNITED
STATES</font></div>
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px"><font style="font-weight: bold; font-size: 24px; font-family: Times New Roman">SECURITIES
AND EXCHANGE COMMISSION</font></div>
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px"><font style="font-weight: bold; font-size: 13px; font-family: Times New Roman">Washington,
D.C. 20549</font></div>
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px"><font style="font-size: 13px; font-family: Times New Roman">&#xA0;</font></div>
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px"><font style="font-weight: bold; font-size: 24px; font-family: Times New Roman">FORM&#xA0;S-8</font></div>
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px"><font style="font-size: 13px; font-family: Times New Roman">&#xA0;</font></div>
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px"><font style="font-weight: bold; font-size: 13px; font-family: Times New Roman">REGISTRATION
STATEMENT UNDER THE SECURITIES ACT OF 1933</font></div>
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px"><font style="font-size: 13px; font-family: Times New Roman">&#xA0;</font></div>
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px"><font style="font-weight: bold; font-size: 24px; font-family: Times New Roman">Monopar
Therapeutics Inc.</font></div>
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px"><font style="font-size: 13px; font-family: Times New Roman">(Exact name of
registrant as specified in its charter)</font></div>
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px"><font style="font-size: 13px; font-family: Times New Roman">&#xA0;</font></div>
<div style="text-align: left; margin-left: 0px; margin-right: 0px;">
<table cellpadding="0" cellspacing="0" style="text-align: left; font-family: inherit; font-size: inherit;width: 100%;">
<tr>
<td style="vertical-align: top; width: 49%">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px"><font style="font-size: 13px; font-family: Times New Roman"><font style="font-weight: bold">Delaware</font></font></div>
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px"><font style="font-size: 13px; font-family: Times New Roman">(State or other
jurisdiction ofincorporation or organization)</font></div>
</td>
<td style="vertical-align: bottom; width: 2%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px"><font style="font-size: 13px; font-family: Times New Roman">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 49%">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px"><font style="font-size: 13px; font-family: Times New Roman"><font style="font-weight: bold">32-0463781</font></font></div>
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px"><font style="font-size: 13px; font-family: Times New Roman">(I.R.S.
EmployerIdentification No.)</font></div>
</td>
</tr></table>
</div>
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px"><font style="font-size: 13px; font-family: Times New Roman">&#xA0;</font></div>
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px"><font style="font-weight: bold; font-size: 13px; font-family: Times New Roman">1000
Skokie Blvd., Suite 350</font></div>
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px"><font style="font-weight: bold; font-size: 13px; font-family: Times New Roman">Wilmette,
IL 60091</font></div>
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px"><font style="font-size: 13px; font-family: Times New Roman">(Address of
principal executive offices) (Zip Code)</font></div>
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px"><font style="font-size: 13px; font-family: Times New Roman">&#xA0;</font></div>
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px"><font style="font-weight: bold; font-size: 13px; font-family: Times New Roman">Monopar
Therapeutics Inc. 2016 Stock Incentive Plan</font></div>
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px"><font style="font-size: 13px; font-family: Times New Roman">(Full title of the
plans)</font></div>
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px"><font style="font-size: 13px; font-family: Times New Roman">&#xA0;</font></div>
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px"><font style="font-weight: bold; font-size: 13px; font-family: Times New Roman">Chandler
Robinson, MD</font></div>
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px"><font style="font-weight: bold; font-size: 13px; font-family: Times New Roman">Chief
Executive Officer</font></div>
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px"><font style="font-weight: bold; font-size: 13px; font-family: Times New Roman">1000
Skokie Blvd., Suite 350</font></div>
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px"><font style="font-weight: bold; font-size: 13px; font-family: Times New Roman">Wilmette,
IL 60091</font></div>
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px"><font style="font-size: 13px; font-family: Times New Roman">(Name and Address
of agent for service)</font></div>
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px"><font style="font-size: 13px; font-family: Times New Roman">&#xA0;</font></div>
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px"><font style="font-weight: bold; font-size: 13px; font-family: Times New Roman">(847)
388-0349</font></div>
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px"><font style="font-size: 13px; font-family: Times New Roman">&#xA0;(Telephone
number, including area code, of agent for service)</font></div>
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px"><font style="font-size: 13px; font-family: Times New Roman"><br></font></div>
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px"><font style="font-size: 13px; font-family: Times New Roman">&#xA0;</font></div>
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px"><font style="font-weight: bold; font-size: 13px; font-family: Times New Roman">With
a copy to:</font></div>
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px"><font style="font-size: 13px; font-family: Times New Roman">&#xA0;</font></div>
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px"><font style="font-weight: bold; font-size: 13px; font-family: Times New Roman">Robert
Rupp, Esq.</font></div>
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px"><font style="font-size: 13px; font-family: Times New Roman"><font style="font-weight: bold">John J. Harrington</font><br></font></div>
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px"><font style="font-weight: bold; font-size: 13px; font-family: Times New Roman">Baker
&amp; Hostetler LLP</font></div>
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px"><font style="font-weight: bold; font-size: 13px; font-family: Times New Roman">200
Civic Center Drive, Suite 1200</font></div>
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: -12px"><font style="font-weight: bold; font-size: 13px; font-family: Times New Roman">Columbus,
OH 43215</font></div>
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: -12px"><font style="font-weight: bold; font-size: 13px; font-family: Times New Roman">(614)
228-1541</font></div>
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px"><font style="font-size: 13px; font-family: Times New Roman">&#xA0;</font></div>
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px"><font style="font-size: 13px; font-family: Times New Roman">Indicate by check
mark whether the registrant is a large accelerated filer, an
accelerated filer, a non-accelerated filer, or a smaller reporting
company.&#xA0;&#xA0;See definitions of &#x201C;large accelerated
filer,&#x201D; &#x201C;accelerated filer&#x201D; and &#x201C;smaller
reporting company&#x201D; in Rule&#xA0;12b-2 of the Exchange
Act.&#xA0;&#xA0;(Check one):</font></div>
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px"><font style="font-size: 13px; font-family: Times New Roman">&#xA0;</font></div>
<div style="text-align: left; margin-left: 0px; margin-right: 0px;">
<table cellpadding="0" cellspacing="0" style="text-align: left; font-family: inherit; font-size: inherit;width: 100%;">
<tr>
<td style="vertical-align: top; width: 30%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px"><font style="font-size: 13px; font-family: Times New Roman">&#xA0;&#xA0;Large
accelerated filer&#xA0;&#x2610;</font></div>
</td>
<td style="vertical-align: top; width: 29%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px"><font style="font-size: 13px; font-family: Times New Roman">Accelerated
filer&#xA0; &#xA0;&#x2610;</font></div>
</td>
<td style="vertical-align: top; width: 42%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px"><font style="font-size: 13px; font-family: Times New Roman">Non-accelerated
filer&#xA0;&#xA0;&#xA0;&#x2610;</font></div>
</td>
</tr><tr>
<td style="vertical-align: top; width: 30%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px"><font style="font-size: 13px; font-family: Times New Roman">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 29%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px"><font style="font-size: 13px; font-family: Times New Roman">Smaller Reporting
Company&#xA0;&#x2612;</font></div>
</td>
<td style="vertical-align: top; width: 42%">
<div style="text-align: right; margin-left: 0px; margin-right: 0px; text-indent: 0px"><font style="font-size: 13px; font-family: Times New Roman">Emerging growth
company&#xA0;&#x2612;</font></div>
</td>
</tr></table>
</div>
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px"><font style="font-size: 13px; font-family: Times New Roman">&#xA0;</font></div>
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px"><font style="font-size: 13px; font-family: Times New Roman">If an emerging
growth company, indicate by check mark if the registrant has
elected not to use the extended transition period for complying
with any new or revised financial accounting standards provided
pursuant to Section&#xA0;7(a)(2)(B)&#xA0;of the Securities
Act.&#xA0;&#xA0;&#x2612;</font></div>
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px"><font style="font-size: 13px; font-family: Times New Roman">&#xA0;</font></div>
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px"><font style="font-weight: bold; color: #000000; font-size: 13px; font-family: Times New Roman">
CALCULATION OF REGISTRATION FEE</font></div>
<div style="text-align: left; margin-left: 0px; margin-right: 0px;">
<table cellpadding="0" cellspacing="0" style="text-align: left; font-family: inherit; font-size: inherit;text-align: left; padding-top: 0px; padding-bottom: 0px; margin-left: 0px; margin-right: auto; width: 100%;">
<tr style="background-color: #cceeff">
<td colspan="1" rowspan="1" style="vertical-align: bottom; width: 30%">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px"><font style="font-weight: bold; font-size: 13px; font-family: Times New Roman">Title&#xA0;of&#xA0;Securities
to&#xA0;be&#xA0;Registered</font></div>
</td>
<td rowspan="1" style="vertical-align: bottom; width: 15%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px"><font style="text-align: left; width: 10%; vertical-align: bottom; display: inline-block; padding-bottom: 2px">&#xA0;</font><font style="text-align: center; vertical-align: bottom; width: 80%; display: inline-block; border-bottom: 2px solid #000000">
<div><font style="font-weight: bold; font-size: 13px; font-family: Times New Roman">Amount&#xA0;to
be Registered<font style="font-size: 70%; vertical-align: top">(1)</font></font></div>
</font><font style="text-align: left; width: 10%; vertical-align: bottom; display: inline-block; padding-bottom: 2px">&#xA0;</font></div>
</td>
<td colspan="1" rowspan="1" style="vertical-align: bottom; width: 15%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px"><font style="text-align: left; width: 10%; vertical-align: bottom; display: inline-block; padding-bottom: 2px">&#xA0;</font><font style="text-align: center; vertical-align: bottom; width: 80%; display: inline-block; border-bottom: 2px solid #000000">
<div><font style="font-weight: bold; font-size: 13px; font-family: Times New Roman">Proposed
Maximum&#xA0;Offering Price&#xA0;Per&#xA0;Share</font></div>
</font><font style="text-align: left; width: 10%; vertical-align: bottom; display: inline-block; padding-bottom: 2px">&#xA0;</font></div>
</td>
<td colspan="1" rowspan="1" style="vertical-align: bottom; width: 15%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px"><font style="text-align: left; width: 10%; vertical-align: bottom; display: inline-block; padding-bottom: 2px">&#xA0;</font><font style="text-align: center; vertical-align: bottom; width: 80%; display: inline-block; border-bottom: 2px solid #000000">
<div><font style="font-weight: bold; font-size: 13px; font-family: Times New Roman">Proposed
Maximum Aggregate&#xA0;Offering Price</font></div>
</font><font style="text-align: left; width: 10%; vertical-align: bottom; display: inline-block; padding-bottom: 2px">&#xA0;</font></div>
</td>
<td colspan="1" rowspan="1" style="vertical-align: bottom; width: 15%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px"><font style="text-align: left; width: 10%; vertical-align: bottom; display: inline-block; padding-bottom: 2px">&#xA0;</font><font style="text-align: center; vertical-align: bottom; width: 80%; display: inline-block; border-bottom: 2px solid #000000">
<div><font style="font-weight: bold; font-size: 13px; font-family: Times New Roman">Amount&#xA0;of
Registration&#xA0;Fee</font></div>
</font><font style="text-align: left; width: 10%; vertical-align: bottom; display: inline-block; padding-bottom: 2px">&#xA0;</font></div>
</td>
</tr><tr style="background-color: #ffffff">
<td colspan="1" style="vertical-align: bottom; width: 30%">
<div style="text-align: left; margin-left: 24px; margin-right: 0px; text-indent: -24px"><font style="font-size: 13px; font-family: Times New Roman">Common Stock,
$0.001 par value</font></div>
</td>
<td style="vertical-align: bottom; width: 15%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px"><font style="text-align: left; vertical-align: bottom; display: inline-block; width: 10%; padding-bottom: 2px; font-size: 13px; font-family: Times New Roman">&#xA0;</font><font style="text-align: left; vertical-align: bottom; display: inline-block; width: 5%; padding-bottom: 2px; font-size: 13px; font-family: Times New Roman">&#xA0;</font><font style="text-align: right; display: inline-block; width: 75%; padding-bottom: 2px; font-size: 13px; font-family: Times New Roman;">1,500,000<font style="font-size: 70%; vertical-align: top; font-family: Times New Roman">(2)</font></font><font style="text-align: left; vertical-align: bottom; display: inline-block; width: 10%; padding-bottom: 2px; font-size: 13px; font-family: Times New Roman"><font style="vertical-align: top;"></font></font></div>
</td>
<td colspan="1" style="vertical-align: bottom; width: 15%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px"><font style="text-align: left; vertical-align: bottom; display: inline-block; width: 10%; padding-bottom: 2px; font-size: 13px; font-family: Times New Roman">&#xA0;</font><font style="text-align: left; vertical-align: bottom; display: inline-block; width: 5%; padding-bottom: 2px; font-size: 13px; font-family: Times New Roman">$</font><font style="text-align: right; vertical-align: bottom; display: inline-block; width: 75%; padding-bottom: 2px; font-size: 13px; font-family: Times New Roman">4.435</font><font style="text-align: left; vertical-align: bottom; display: inline-block; width: 10%; padding-bottom: 2px; font-size: 13px; font-family: Times New Roman">&#xA0;</font></div>
</td>
<td colspan="1" style="vertical-align: bottom; width: 15%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px"><font style="text-align: left; vertical-align: bottom; display: inline-block; width: 10%; padding-bottom: 2px; font-size: 13px; font-family: Times New Roman">&#xA0;</font><font style="text-align: left; vertical-align: bottom; display: inline-block; width: 5%; padding-bottom: 2px; font-size: 13px; font-family: Times New Roman">$</font><font style="text-align: right; vertical-align: bottom; display: inline-block; width: 75%; padding-bottom: 2px; font-size: 13px; font-family: Times New Roman">6,652,500<font style="font-size: 70%; vertical-align: top; font-family: Times New Roman">(3)</font></font><font style="text-align: left; vertical-align: bottom; display: inline-block; width: 10%; padding-bottom: 2px; font-size: 13px; font-family: Times New Roman"><font style="vertical-align: top;"></font></font></div>
</td>
<td colspan="1" style="vertical-align: bottom; width: 15%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px"><font style="text-align: left; vertical-align: bottom; display: inline-block; width: 10%; font-size: 13px; font-family: Times New Roman">&#xA0;</font><font style="text-align: left; vertical-align: bottom; display: inline-block; width: 5%; font-size: 13px; font-family: Times New Roman">$</font><font style="text-align: right; vertical-align: bottom; display: inline-block; width: 75%; font-size: 13px; font-family: Times New Roman">726</font><font style="text-align: left; vertical-align: bottom; display: inline-block; width: 10%; font-size: 13px; font-family: Times New Roman">&#xA0;</font></div>
</td>
</tr></table>
</div>
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px"><font style="color: #000000; font-size: 13px; font-family: Times New Roman">&#xA0;</font></div>
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px"><font style="font-size: 13px; font-family: Times New Roman">&#xA0;</font><font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
<div style="margin-left: 12px; display: table">
<div style="display: table-row">
<div style="text-align: left; display: table-cell; width: 24px">
<font style="font-family: Times New Roman; font-size: 13px">(1)</font></div>
<div style="text-align: justify; display: table-cell"><font style="font-family: Times New Roman; font-size: 13px">Pursuant to Rule
416(a) under the Securities Act of 1933, as amended, this
Registration Statement shall also cover any additional shares of
common stock (&#x201C;Common Stock&#x201D;) of Monopar Therapeutics
Inc. (the &#x201C;Registrant&#x201D;) that become issuable under the
Registrant&#x2019;s 2016 Stock Incentive Plan (the
&#x201C;Plan&#x201D;), by reason of any stock dividend, stock split,
recapitalization or other similar transaction that increases the
number of the outstanding shares of the Registrant&#x2019;s common
stock.</font></div>
</div>
</div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 10">&#xA0;</font>
<font style="font-family: Times New Roman; font-size: 13px"><br>
</font></div>
<div style="margin-left: 12px; display: table">
<div style="display: table-row">
<div style="text-align: left; display: table-cell; width: 24px">
<font style="font-family: Times New Roman; font-size: 13px">(2)</font></div>
<div style="text-align: justify; display: table-cell"><font style="font-family: Times New Roman; font-size: 13px">Represents shares
of Common Stock reserved for future grant under the
Plan.</font></div>
</div>
</div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 10">&#xA0;</font>
<font style="font-family: Times New Roman; font-size: 13px"><br>
</font></div>
<div style="margin-left: 12px; display: table">
<div style="display: table-row">
<div style="text-align: left; display: table-cell; width: 24px">
<font style="font-family: Times New Roman; font-size: 13px">(3)</font></div>
<div style="text-align: justify; display: table-cell"><font style="font-family: Times New Roman; font-size: 13px">Estimated solely
for purposes of calculating the registration fee in accordance with
Rule 457(h) of the Securities Act of 1933, as amended, by averaging
the high and low sales prices of the Registrant&#x2019;s common
stock reported on the Nasdaq Capital Market as of a date (November
6, 2020) within five business days prior to filing this
Registration Statement.</font></div>
</div>
</div>
<div><font>&#xA0;</font></div>
<div><font style="font-family: Times New Roman; font-size: 13px;">&#xA0;</font><br>
</div>
<font style="font-size: 13px; font-family: Times New Roman">&#xA0;</font>
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px"><font style="font-size: 13px; font-family: Times New Roman">&#xA0;</font></div>
<div id="pgbrk" style="width: 100%; margin-left: 0px; text-indent: 0px; margin-right: 0px">
<div id="ftr" style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px; width: 100%"><font style="font-size: 13px; font-family: Times New Roman">&#xA0;</font></div>
</div>
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<div id="hdr" style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px; width: 100%"><font style="font-size: 13px; font-family: Times New Roman">&#xA0;</font></div>
</div>
</div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px"><font style="font-size: 13px; font-family: Times New Roman">&#xA0;</font></div>
<div><font style="font-family: Times New Roman; font-size: 10">&#xA0;</font></div>
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px;">
<font style="font-weight: bold; font-family: Times New Roman; font-size: 13px">REGISTRATION
OF ADDITIONAL SHARES PURSUANT TO GENERAL INSTRUCTION E</font></div>
<div><font style="font-family: Times New Roman; font-size: 10">&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
<div><font style="font-family: Times New Roman; font-size: 10">&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
<div><font style="font-family: Times New Roman; font-size: 10">&#xA0;</font></div>
<div style="text-align: justify; margin-left: 12px; margin-right: 3px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">This
Registration Statement on Form S-8 (the &#x201C;Registration
Statement&#x201D;) of Monopar Therapeutics Inc. (the
&#x201C;Company&#x201D; or the &#x201C;Registrant&#x201D;) is being
filed pursuant to General Instruction E to Form S-8 under the
Securities Act of 1933, as amended, to register 1,500,000
additional shares of the Company&#x2019;s common stock, $0.001 par
value per share (the &#x201C;Common Stock&#x201D;), under the 2016
Stock Incentive Plan (the &#x201C;Plan&#x201D;). This Registration
Statement on Form S-8 hereby incorporates by reference the contents
of the Registrant&#x2019;s registration statement on Form S-8 filed
with the Securities and Exchange Commission (the
&#x201C;Commission&#x201D;) on January 3, 2020 (Registration No.
333-235790).</font></div>
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px"><font style="font-family: Times New Roman; font-size: 13px;">&#xA0;</font></div>
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px"><font style="font-family: Times New Roman; font-size: 13px;">&#xA0;</font></div>
<div id="pgbrk" style="width: 100%; margin-left: 0px; text-indent: 0px; margin-right: 0px">
<div id="ftr">
<div style="text-align: left; width: 100%"><font style="font-family: Times New Roman; font-size: 11px">&#xA0;</font></div>
</div>
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<div id="hdr">
<div style="text-align: right; width: 100%"><font style="font-family: Times New Roman; font-size: 11px">&#xA0;</font></div>
</div>
</div>
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px"><font style="font-family: Times New Roman; font-size: 13px;">&#xA0;</font></div>
<br>
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px"><font style="font-size: 13px; font-family: Times New Roman">&#xA0;</font></div>
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px"><font style="font-weight: bold; font-size: 13px; font-family: Times New Roman">PART&#xA0;II</font></div>
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px"><font style="font-size: 13px; font-family: Times New Roman">&#xA0;</font></div>
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px"><font style="font-weight: bold; font-size: 13px; font-family: Times New Roman">INFORMATION
REQUIRED IN THE REGISTRATION STATEMENT<br></font></div>
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px"><font style="font-size: 13px; font-family: Times New Roman">&#xA0;</font></div>
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px"><font style="font-weight: bold; font-size: 13px; font-family: Times New Roman">Item
3. Incorporation of Documents by Reference</font></div>
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px"><font style="font-size: 13px; font-family: Times New Roman">&#xA0;</font></div>
<div><font style="font-family: Times New Roman; font-size: 10">&#xA0;</font></div>
<div style="text-align: left; margin-left: 12px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">The
following documents filed by the Registrant with the Commission are
incorporated herein by reference:</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 10">&#xA0;</font>
<font style="font-family: Times New Roman; font-size: 13px"><br>
</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
<div style="display: table;">
<div style="display: table-row;">
<div style="text-align: right; display: table-cell; width: 4px; padding-right: 8px;"><font style="font-family: Times New Roman; font-size: 13px;">&#x25CF;</font></div>
<div style="text-align: justify; display: table-cell; margin-left: 0px; text-indent: 0px; margin-right: 0px;"><font style="font-family: Times New Roman; font-size: 13px">The
Registrant&#x2019;s Quarterly Report on<font style="color: #0000ED">&#xA0;<a href="http://www.sec.gov/Archives/edgar/data/1645469/000165495420012194/0001654954-20-012194-index.htm">Form
10-Q</a>&#xA0;</font>for the quarter ended September 30, 2020,
filed with the SEC on November 12, 2020;</font></div>
</div>
</div>
<div style="text-align: left; margin-left: 0px; text-indent: 0px; margin-right: 0px;"><font style="font-family: Times New Roman; font-size: 10">&#xA0;</font></div>

<div style="display: table;">
<div style="display: table-row;">
<div style="text-align: right; display: table-cell; width: 4px; padding-right: 8px;"><font style="font-family: Times New Roman; font-size: 13px;">&#x25CF;</font></div>
<div style="text-align: justify; display: table-cell; margin-left: 0px; text-indent: 0px; margin-right: 0px;"><font style="font-family: Times New Roman; font-size: 13px">The
Registrant&#x2019;s Quarterly Report on<font style="color: #0000ED">&#xA0;</font><a href="http://www.sec.gov/Archives/edgar/data/1645469/000165495420008590/0001654954-20-008590-index.htm"><font style="color: rgb(0, 0, 255);">Form
10-Q</font></a><font style="color: #0000ED">&#xA0;</font>for the
quarter ended June 30, 2020, filed with the SEC on August 6,
2020;</font></div>
</div>
</div>
<div style="display: table;">
<div style="display: table-row;">
<div style="text-align: justify; display: table-cell; margin-left: 0px; text-indent: 0px; margin-right: 0px;"><font style="font-family: Times New Roman; font-size: 13px;">&#xA0;<br></font></div>
</div>
</div>
<div style="display: table;">
<div style="display: table-row;">
<div style="text-align: right; display: table-cell; width: 4px; padding-right: 8px;"><font style="font-family: Times New Roman; font-size: 13px;">&#x25CF;</font></div>
<div style="text-align: justify; display: table-cell; margin-left: 0px; text-indent: 0px; margin-right: 0px;"><font style="font-family: Times New Roman; font-size: 10">&#xA0;</font><font style="font-family: Times New Roman; font-size: 13px">The
Registrant&#x2019;s Quarterly Report on<font style="color: #0000ED">&#xA0;</font><a href="http://www.sec.gov/Archives/edgar/data/1645469/000165495420005004/0001654954-20-005004-index.htm"><font style="color: rgb(0, 0, 255);">Form
10-Q</font></a> for the quarter ended March 31, 2020, filed with
the SEC on May 7, 2020;</font></div>
</div>
</div>
<div style="text-align: left; margin-left: 0px; text-indent: 0px; margin-right: 0px;"><font style="font-family: Times New Roman; font-size: 10">&#xA0;</font>&#xA0;</div>
<div style="display: table;">
<div style="display: table-row;">
<div style="text-align: right; display: table-cell; width: 4px; padding-right: 8px;"><font style="font-family: Times New Roman; font-size: 13px;">&#x25CF;</font></div>
<div style="text-align: justify; display: table-cell; margin-left: 0px; text-indent: 0px; margin-right: 0px;"><font style="font-family: Times New Roman; font-size: 13px">The
Registrant&#x2019;s Annual Report on<font style="color: #0000ED">&#xA0;</font><a href="http://www.sec.gov/Archives/edgar/data/1645469/000165495420003363/0001654954-20-003363-index.htm"><font style="color: rgb(0, 0, 255);">Form
10-K</font></a><font style="color: #0000ED">&#xA0;</font>for the
year ended December 31, 2019, filed with the SEC on March 27, 2020;
and</font></div>
</div>
</div>
<div style="text-align: left; margin-left: 0px; text-indent: 0px; margin-right: 0px;"><font style="font-family: Times New Roman; font-size: 10">&#xA0;</font></div>

<div style="display: table;">
<div style="display: table-row;">
<div style="text-align: right; display: table-cell; width: 4px; padding-right: 8px;"><font style="font-family: Times New Roman; font-size: 13px;">&#x25CF;</font></div>
<div style="text-align: justify; display: table-cell; margin-left: 0px; text-indent: 0px; margin-right: 0px;"><font style="font-family: Times New Roman; font-size: 13px">The
Registrant&#x2019;s Current Reports on Form 8-K, filed with the SEC
on<font style="color: #0000ED">&#xA0;</font><a href="http://www.sec.gov/Archives/edgar/data/1645469/000165495420000166/0001654954-20-000166-index.htm"><font style="color: rgb(0, 0, 255);">January
7, 2020</font></a><font style="color: #0000ED">,</font> <a href="http://www.sec.gov/Archives/edgar/data/1645469/000165495420000375/0001654954-20-000375-index.htm">
<font style="color: rgb(0, 0, 255);">January 13,
2020</font></a><font style="color: #0000ED">,</font> <a href="http://www.sec.gov/Archives/edgar/data/1645469/000165495420006657/0001654954-20-006657-index.htm">
<font style="color: rgb(0, 0, 255);">June 15,
2020</font></a><font style="color: #0000ED">,</font> <a href="http://www.sec.gov/Archives/edgar/data/1645469/000165495420006669/0001654954-20-006669-index.htm">
<font style="color: rgb(0, 0, 255);">June 16,
2020</font></a><font style="color: #0000ED">,</font> to the extent
the information in such reports is filed and not
furnished.</font></div>
</div>
</div>
<div><font style="font-family: Times New Roman; font-size: 10">&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
<div style="text-align: justify; margin-left: 12px; margin-right: 3px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">All
reports and other documents filed by the Registrant after the date
hereof pursuant to Sections 13(a), 13(c), 14 and 15(d) of the
Securities Exchange Act of 1934, as amended, prior to the filing of
a post-effective amendment which indicates that all securities
offered hereby have been sold or which deregisters all securities
then remaining unsold, shall be deemed to be incorporated by
reference herein and to be part hereof from the date of filing of
such reports and documents. Any statement contained in a document
incorporated or deemed to be incorporated by reference herein shall
be deemed to be modified or superseded for the purposes of this
Registration Statement to the extent that a statement contained
herein or in any other subsequently filed document which also is or
is deemed to be incorporated by reference herein modifies or
supersedes such statement. Any statement so modified or superseded
shall not be deemed, except as so modified or superseded, to
constitute a part of this Registration Statement.</font></div>
<div><font>&#xA0;</font></div>
<div><font style="font-family: Times New Roman; font-size: 13px;">&#xA0;</font></div>
<div><font style="font-family: Times New Roman; font-size: 13px;">&#xA0;</font></div>
<div style="text-align: left; margin-left: 12px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; font-family: Times New Roman; font-size: 13px">Item
8. Exhibits</font></div>
<div><font style="font-family: Times New Roman; font-size: 10">&#xA0;</font></div>
<div><font style="font-family: Times New Roman; font-size: 13px;">&#xA0;</font></div>
<font style="font-size: 13px; font-family: Times New Roman">&#xA0;</font>
<div style="text-align: left; margin-left: 0px; margin-right: 0px;">
<table cellpadding="0" cellspacing="0" style="text-align: left; font-family: inherit; font-size: inherit;padding-top: 0px; padding-bottom: 0px; margin-left: 0px; margin-right: auto; width: 100%;">
<tr>
<td style="width: 10%; border-bottom: 2px solid #000000">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px"><font style="font-size: 13px"><font style="font-weight: bold">&#xA0;Exhibit
Number&#xA0;&#xA0;&#xA0;<br></font></font></div>
</td>
<td style="width: 2%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px"><font style="font-size: 13px"><font style="font-weight: bold">&#xA0;</font></font></div>
</td>
<td style="width: 84%; border-bottom: 2px solid #000000">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px"><font style="font-size: 13px"><font style="font-weight: bold">&#xA0;Description<br></font></font></div>
</td>
<td style="width: 4%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px"><font>&#xA0;</font></div>
</td>
</tr><tr style="background-color: #cceeff">
<td style="width: 10%">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px"><font style="font-size: 13px">&#xA0;5.1</font></div>
</td>
<td style="width: 2%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px"><font style="font-size: 13px">&#xA0;</font></div>
</td>
<td style="width: 84%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px"><font style="font-size: 13px">&#xA0;Opinion of Legal
Counsel<br></font></div>
</td>
<td style="width: 4%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px"><font>&#xA0;</font></div>
</td>
</tr><tr>
<td style="width: 10%">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px"><font style="font-size: 13px">&#xA0;10.1</font></div>
</td>
<td style="width: 2%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px"><font style="font-size: 13px">&#xA0;</font></div>
</td>
<td style="width: 84%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px"><font style="font-size: 13px">&#xA0;<font style="font-family: Times New Roman;">Monopar Therapeutics&#xA0;Inc. 2016
Stock Incentive Plan (incorporated by reference to Appendix A to
the Registrant&#x2019;s DEF14A Proxy Statement (file number
001-39070), filed with the SEC on April 29,
2020)</font></font></div>
</td>
<td style="width: 4%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px"><font>&#xA0;</font></div>
</td>
</tr><tr style="background-color: #cceeff">
<td style="width: 10%">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px"><font style="font-size: 13px">&#xA0;23.1</font></div>
</td>
<td style="width: 2%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px"><font style="font-size: 13px">&#xA0;</font></div>
</td>
<td style="width: 84%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px"><font style="font-size: 13px">&#xA0;<font style="font-family: Times New Roman;">Consent</font> of Independent
Registered Public Accounting Firm</font></div>
</td>
<td style="width: 4%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px"><font>&#xA0;</font></div>
</td>
</tr><tr>
<td style="width: 10%">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px"><font style="font-size: 13px">&#xA0;23.2</font></div>
</td>
<td style="width: 2%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px"><font style="font-size: 13px">&#xA0;</font></div>
</td>
<td style="width: 84%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px"><font style="font-size: 13px">&#xA0;<font style="font-family: Times New Roman;">Consent of Legal Counsel (included
in Exhibit 5.1)</font></font></div>
</td>
<td style="width: 4%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px"><font>&#xA0;</font></div>
</td>
</tr><tr style="background-color: #cceeff">
<td style="width: 10%">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px"><font style="font-size: 13px">&#xA0;24.1</font></div>
</td>
<td style="width: 2%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px"><font style="font-size: 13px">&#xA0;</font></div>
</td>
<td style="width: 84%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px"><font style="font-size: 13px">&#xA0;<font style="font-family: Times New Roman;">Power of Attorney (included on
signature page)</font><br></font></div>
</td>
<td style="width: 4%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px"><font><br></font></div>
</td>
</tr></table>
</div>
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px"><font>&#xA0;</font></div>
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px"><font style="font-size: 13px; font-family: Times New Roman">&#xA0;</font></div>
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px"><font style="font-size: 13px; font-family: Times New Roman">&#xA0;</font></div>
<br>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px"><font style="font-size: 13px; font-family: Times New Roman">&#xA0;</font></div>
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px"><font style="color: #000000; font-size: 13px; font-family: Times New Roman">&#xA0;</font></div>
<div id="pgbrk" style="width: 100%; margin-left: 0px; text-indent: 0px; margin-right: 0px">
<div id="ftr" style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px; width: 100%"><font style="font-size: 13px; font-family: Times New Roman">&#xA0;</font></div>
</div>
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<div id="hdr" style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px; width: 100%"><font style="font-size: 13px; font-family: Times New Roman">&#xA0;</font></div>
</div>
</div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px"><font style="font-size: 13px; font-family: Times New Roman">&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px"><font style="font-size: 13px; font-family: Times New Roman">&#xA0;</font></div>
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px"><font style="font-weight: bold; color: #000000; font-size: 13px; font-family: Times New Roman">
<a name="Signatures">S</a>IGNATURES</font></div>
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px"><font style="color: #000000; font-size: 13px; font-family: Times New Roman">&#xA0;</font></div>
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 24px"><font style="font-size: 13px; font-family: Times New Roman"><font style="color: #000000">Pursuant to the requirements of the Securities Act
of 1933, as amended, the Registrant certifies that it has
reasonable grounds to believe that it meets all of the requirements
for filing on Form&#xA0;S-8 and has duly caused this Registration
Statement to be signed on its behalf by the undersigned, thereunto
duly authorized, in Wilmette, Illinois, on the</font> 12th day
<font style="color: #000000">of November, 2020.</font></font></div>
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px"><font style="color: #000000; font-size: 13px; font-family: Times New Roman">&#xA0;</font></div>
<div style="text-align: left; margin-left: 0px; margin-right: 0px;">
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</td>
<td colspan="2" style="vertical-align: top; width: 40%;">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px"><font style="font-size: 13px; font-family: Times New Roman"><font style="font-weight: bold">MONOPAR THERAPEUTICS INC.</font></font></div>
</td>
</tr><tr>
<td style="vertical-align: top; width: 60%;">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px"><font style="font-size: 13px; font-family: Times New Roman">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 4%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px"><font style="font-size: 13px; font-family: Times New Roman">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 36%;">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px"><font style="font-size: 13px; font-family: Times New Roman">&#xA0;</font></div>
</td>
</tr><tr>
<td style="vertical-align: top; width: 60%;">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px"><font style="font-size: 13px; font-family: Times New Roman">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 4%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px"><font style="font-size: 13px; font-family: Times New Roman">By:</font></div>
</td>
<td style="vertical-align: top; width: 36%; border-bottom: 1px solid rgb(0, 0, 0);">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px"><font style="font-size: 13px; font-family: Times New Roman">/s/ Chandler D.
Robinson</font></div>
</td>
</tr><tr>
<td style="vertical-align: top; width: 60%;">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px"><font style="font-size: 13px; font-family: Times New Roman">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 4%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px"><font style="font-size: 13px; font-family: Times New Roman">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 36%;">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px"><font style="font-size: 13px; font-family: Times New Roman">Chandler D.
Robinson</font></div>
</td>
</tr><tr>
<td style="vertical-align: top; width: 60%;">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px"><font style="font-size: 13px; font-family: Times New Roman">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 4%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px"><font style="font-size: 13px; font-family: Times New Roman">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 36%;">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px"><font style="font-size: 13px; font-family: Times New Roman">Chief Executive
Officer and Director</font></div>
</td>
</tr></table>
</div>
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px"><font style="color: #000000; font-size: 13px; font-family: Times New Roman">&#xA0;</font></div>
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px"><font style="font-size: 13px; font-family: Times New Roman">&#xA0;</font></div>
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px"><font style="font-weight: bold; color: #000000; font-size: 13px; font-family: Times New Roman">
POWER OF ATTORNEY</font></div>
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px"><font style="color: #000000; font-size: 13px; font-family: Times New Roman">&#xA0;</font></div>
<div><font style="font-family: Times New Roman; font-size: 10">&#xA0;</font></div>
<div style="text-align: justify; margin-left: 12px; margin-right: 14px; text-indent: 24px">
<font style="font-family: Times New Roman; font-size: 13px">KNOW
ALL PERSONS BY THESE PRESENTS, that each person whose signature
appears below constitutes and appoints Chandler D. Robinson,
his/her true and lawful attorney-in-fact and agent with full power
of substitution and re-substitution, for him/her and in his/her
name, place and stead, in any and all capacities to sign any or all
amendments (including, without limitation, post-effective
amendments) to this Registration Statement, any related
Registration Statement filed pursuant to Rule 462(b) under the
Securities Act of 1933 and any or all pre- or post-effective
amendments thereto, and to file the same, with all exhibits
thereto, and all other documents in connection therewith, with the
Securities and Exchange Commission, granting unto said
attorney-in-fact and agent, full power and authority to do and
perform each and every act and thing requisite and necessary to be
done in and about the premises, as fully for all intents and
purposes as he/she might or could do in person, hereby ratifying
and confirming that said attorney-in-fact and agent, or any
substitute or substitutes for him, may lawfully do or cause to be
done by virtue hereof.</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
<div style="text-align: left; margin-left: 36px; margin-right: 0px; text-indent: 0px;">
<font style="font-family: Times New Roman; font-size: 13px">Pursuant to the
requirements of the Securities Act of 1933, the following persons
in the capacities and on the dates indicated have signed this
Registration Statement below.</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px"><font style="font-size: 13px; font-family: Times New Roman">&#xA0;</font></div>
<div style="text-align: left; margin-left: 0px; margin-right: 0px;">
<table cellpadding="0" cellspacing="0" style="text-align: left; font-family: inherit; font-size: inherit;margin-left: 0px; margin-right: 0px; width: 100%;">
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<td rowspan="1" style="vertical-align: top; width: 28%; padding-bottom: 2px; border-bottom: 2px solid rgb(0, 0, 0);">
<div style="text-align: center; margin-left: 0px; margin-right: 27px; text-indent: -12px"><font style="font-weight: bold; font-size: 13px; font-family: Times New Roman">Signatures</font></div>
</td>
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</td>
<td rowspan="1" style="vertical-align: top; width: 44%; padding-bottom: 2px; border-bottom: 2px solid rgb(0, 0, 0);">
<div style="text-align: center; margin-left: 0px; margin-right: 89px; text-indent: 0px"><font style="font-weight: bold; font-size: 13px; font-family: Times New Roman">Title</font></div>
</td>
<td rowspan="1" style="vertical-align: top; width: 0%; padding-bottom: 2px">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px"><font style="font-size: 13px; font-family: Times New Roman">&#xA0;</font></div>
</td>
<td rowspan="1" style="vertical-align: top; width: 28%; border-bottom: 2px solid rgb(0, 0, 0);">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px;"><font style="font-weight: bold; font-size: 13px; font-family: Times New Roman">Date</font></div>
</td>
</tr><tr style="background-color: #ffffff">
<td style="vertical-align: top; width: 28%; border-bottom: 2px solid #000000">
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px"><font style="font-size: 13px; font-family: Times New Roman">&#xA0;</font></div>
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px"><font style="font-size: 13px; font-family: Times New Roman">/s/ Chandler D.
Robinson</font></div>
</td>
<td style="vertical-align: top; width: 0%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px"><font style="font-size: 13px; font-family: Times New Roman">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 44%">
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</td>
<td style="vertical-align: top; width: 0%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px"><font style="font-size: 13px; font-family: Times New Roman">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 28%">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px"><font style="font-size: 13px; font-family: Times New Roman">&#xA0;</font></div>
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px"><font style="font-size: 13px; font-family: Times New Roman">November 12,
2020</font></div>
</td>
</tr><tr style="background-color: #cceeff">
<td style="vertical-align: top; width: 28%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px"><font style="font-size: 13px; font-family: Times New Roman">Chandler D.
Robinson</font></div>
</td>
<td style="vertical-align: top; width: 0%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px"><font style="font-size: 13px; font-family: Times New Roman">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 44%">
<div style="text-align: left; margin-left: 0px; margin-right: 53px; text-indent: 0px"><font style="font-size: 13px; font-family: Times New Roman">Chief Executive
Officer and Director (Principal Executive Officer)</font></div>
</td>
<td style="vertical-align: top; width: 0%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px"><font style="font-size: 13px; font-family: Times New Roman">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 28%">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px"><font style="font-size: 13px; font-family: Times New Roman">&#xA0;</font></div>
</td>
</tr><tr style="background-color: #ffffff">
<td style="vertical-align: top; width: 28%; border-bottom: 2px solid #000000">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px"><font style="font-size: 13px; font-family: Times New Roman">/s/ Kim R.
Tsuchimoto</font></div>
</td>
<td style="vertical-align: top; width: 0%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px"><font style="font-size: 13px; font-family: Times New Roman">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 44%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px"><font style="font-size: 13px; font-family: Times New Roman">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 0%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px"><font style="font-size: 13px; font-family: Times New Roman">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 28%">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px"><font style="font-size: 13px; font-family: Times New Roman"><font style="font-size: 13px; font-family: Times New Roman">November 12</font>,
2020</font></div>
</td>
</tr><tr style="background-color: #cceeff">
<td style="vertical-align: top; width: 28%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px"><font style="font-size: 13px; font-family: Times New Roman">Kim R.
Tsuchimoto</font></div>
</td>
<td style="vertical-align: top; width: 0%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px"><font style="font-size: 13px; font-family: Times New Roman">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 44%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px"><font style="font-size: 13px; font-family: Times New Roman">Chief Financial
Officer (Principal Financial and Accounting Officer)</font></div>
</td>
<td style="vertical-align: top; width: 0%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px"><font style="font-size: 13px; font-family: Times New Roman">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 28%">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px"><font style="font-size: 13px; font-family: Times New Roman">&#xA0;</font></div>
</td>
</tr><tr style="background-color: #ffffff">
<td style="vertical-align: top; width: 28%; border-bottom: 2px solid #000000">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px"><font style="font-size: 13px; font-family: Times New Roman">/s/ Andrew P.
Mazar</font></div>
</td>
<td style="vertical-align: top; width: 0%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px"><font style="font-size: 13px; font-family: Times New Roman">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 44%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px"><font style="font-size: 13px; font-family: Times New Roman">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 0%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px"><font style="font-size: 13px; font-family: Times New Roman">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 28%">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px"><font style="font-size: 13px; font-family: Times New Roman"><font style="font-size: 13px; font-family: Times New Roman"><font style="font-size: 13px; font-family: Times New Roman">November
12</font>,</font> 2020</font></div>
</td>
</tr><tr style="background-color: #cceeff">
<td style="vertical-align: top; width: 28%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px"><font style="font-size: 13px; font-family: Times New Roman">Andrew P.
Mazar</font></div>
</td>
<td style="vertical-align: top; width: 0%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px"><font style="font-size: 13px; font-family: Times New Roman">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 44%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px"><font style="font-size: 13px; font-family: Times New Roman">Chief Scientific
Officer and Director</font></div>
</td>
<td style="vertical-align: top; width: 0%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px"><font style="font-size: 13px; font-family: Times New Roman">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 28%">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px"><font style="font-size: 13px; font-family: Times New Roman">&#xA0;</font></div>
</td>
</tr><tr style="background-color: #ffffff">
<td style="vertical-align: top; width: 28%; border-bottom: 2px solid #000000">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px"><font style="font-size: 13px; font-family: Times New Roman">/s/ Christopher M.
Starr</font></div>
</td>
<td style="vertical-align: top; width: 0%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px"><font style="font-size: 13px; font-family: Times New Roman">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 44%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px"><font style="font-size: 13px; font-family: Times New Roman">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 0%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px"><font style="font-size: 13px; font-family: Times New Roman">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 28%">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px"><font style="font-size: 13px; font-family: Times New Roman"><font style="font-size: 13px; font-family: Times New Roman"><font style="font-size: 13px; font-family: Times New Roman">November
12</font>,</font> 2020</font></div>
</td>
</tr><tr style="background-color: #cceeff">
<td style="vertical-align: top; width: 28%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px"><font style="font-size: 13px; font-family: Times New Roman">Christopher M.
Starr</font></div>
</td>
<td style="vertical-align: top; width: 0%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px"><font style="font-size: 13px; font-family: Times New Roman">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 44%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px"><font style="font-size: 13px; font-family: Times New Roman">Executive Chairman
of the Board and Director</font></div>
</td>
<td style="vertical-align: top; width: 0%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px"><font style="font-size: 13px; font-family: Times New Roman">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 28%">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px"><font style="font-size: 13px; font-family: Times New Roman">&#xA0;</font></div>
</td>
</tr><tr style="background-color: #ffffff">
<td style="vertical-align: top; width: 28%; border-bottom: 2px solid #000000">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px"><font style="font-size: 13px; font-family: Times New Roman">/s/ Raymond W.
Anderson</font></div>
</td>
<td style="vertical-align: top; width: 0%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px"><font style="font-size: 13px; font-family: Times New Roman">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 44%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px"><font style="font-size: 13px; font-family: Times New Roman">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 0%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px"><font style="font-size: 13px; font-family: Times New Roman">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 28%">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px"><font style="font-size: 13px; font-family: Times New Roman"><font style="font-size: 13px; font-family: Times New Roman"><font style="font-size: 13px; font-family: Times New Roman">November
12</font>,</font> 2020</font></div>
</td>
</tr><tr style="background-color: #cceeff">
<td style="vertical-align: top; width: 28%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px"><font style="font-size: 13px; font-family: Times New Roman">Raymond W.
Anderson</font></div>
</td>
<td style="vertical-align: top; width: 0%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px"><font style="font-size: 13px; font-family: Times New Roman">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 44%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px"><font style="font-size: 13px; font-family: Times New Roman">Director</font></div>
</td>
<td style="vertical-align: top; width: 0%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px"><font style="font-size: 13px; font-family: Times New Roman">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 28%">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px"><font style="font-size: 13px; font-family: Times New Roman">&#xA0;</font></div>
</td>
</tr><tr style="background-color: #ffffff">
<td style="vertical-align: top; width: 28%; border-bottom: 2px solid #000000">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px"><font style="font-size: 13px; font-family: Times New Roman">/s/ Michael J.
Brown</font></div>
</td>
<td style="vertical-align: top; width: 0%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px"><font style="font-size: 13px; font-family: Times New Roman">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 44%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px"><font style="font-size: 13px; font-family: Times New Roman">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 0%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px"><font style="font-size: 13px; font-family: Times New Roman">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 28%">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px"><font style="font-size: 13px; font-family: Times New Roman"><font style="font-size: 13px; font-family: Times New Roman"><font style="font-size: 13px; font-family: Times New Roman">November
12</font>,</font> 2020</font></div>
</td>
</tr><tr style="background-color: #cceeff">
<td style="vertical-align: top; width: 28%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px"><font style="font-size: 13px; font-family: Times New Roman">Michael J.
Brown</font></div>
</td>
<td style="vertical-align: top; width: 0%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px"><font style="font-size: 13px; font-family: Times New Roman">&#xA0;</font></div>
</td>
<td style="vertical-align: top; width: 44%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px"><font style="font-size: 13px; font-family: Times New Roman">Director</font></div>
</td>
<td style="vertical-align: top; width: 0%">
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Klausner</font></div>
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12</font>,</font> 2020</font></div>
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<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px"><font style="font-size: 13px; font-family: Times New Roman">Arthur J.
Klausner</font></div>
</td>
<td style="vertical-align: top; width: 0%">
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EXHIBIT INDEX</font></font></div>
<div><font style="font-family: Times New Roman; font-size: 10">&#xA0;</font></div>
<div><font style="font-family: Times New Roman; font-size: 13px;">&#xA0;</font></div>
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<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px"><font style="font-size: 13px"><font style="font-weight: bold">&#xA0;Exhibit
Number&#xA0;&#xA0;&#xA0;<br></font></font></div>
</td>
<td style="width: 2%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px"><font style="font-size: 13px"><font style="font-weight: bold">&#xA0;</font></font></div>
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<td style="width: 84%; border-bottom: 2px solid #000000">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px"><font style="font-size: 13px"><font style="font-weight: bold">&#xA0;Description<br></font></font></div>
</td>
<td style="width: 4%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px"><font>&#xA0;</font></div>
</td>
</tr><tr style="background-color: #cceeff">
<td style="width: 10%">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px"><font style="font-size: 13px">&#xA0;5.1</font></div>
</td>
<td style="width: 2%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px"><font style="font-size: 13px">&#xA0;</font></div>
</td>
<td style="width: 84%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px"><font style="font-size: 13px">&#xA0;<a href="exhibit5opinionforms-8.htm">Opinion of Legal
Counsel</a><br></font></div>
</td>
<td style="width: 4%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px"><font>&#xA0;</font></div>
</td>
</tr><tr>
<td style="width: 10%">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px"><font style="font-size: 13px">&#xA0;10.1</font></div>
</td>
<td style="width: 2%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px"><font style="font-size: 13px">&#xA0;</font></div>
</td>
<td style="width: 84%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px"><font style="font-size: 13px">&#xA0;<font style="font-family: Times New Roman;">Monopar Therapeutics&#xA0;Inc. 2016
Stock Incentive Plan (incorporated by reference to Appendix A to
the Registrant&#x2019;s <a href="http://www.sec.gov/Archives/edgar/data/1645469/000165495420004608/0001654954-20-004608-index.htm">
DEF14A</a> Proxy Statement (file number 001-39070), filed with the
SEC on April 29, 2020)</font></font></div>
</td>
<td style="width: 4%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px"><font>&#xA0;</font></div>
</td>
</tr><tr style="background-color: #cceeff">
<td style="width: 10%">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px"><font style="font-size: 13px">&#xA0;23.1</font></div>
</td>
<td style="width: 2%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px"><font style="font-size: 13px">&#xA0;</font></div>
</td>
<td style="width: 84%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px"><font style="font-size: 13px">&#xA0;<a href="exhibit23-1.htm"><font style="font-family: Times New Roman;">Consent</font> of Independent
Registered Public Accounting Firm</a></font></div>
</td>
<td style="width: 4%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px"><font>&#xA0;</font></div>
</td>
</tr><tr>
<td style="width: 10%">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px"><font style="font-size: 13px">&#xA0;23.2</font></div>
</td>
<td style="width: 2%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px"><font style="font-size: 13px">&#xA0;</font></div>
</td>
<td style="width: 84%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px"><font style="font-size: 13px">&#xA0;<a href="exhibit5opinionforms-8.htm"><font style="font-family: Times New Roman;">Consent of Legal Counsel (included
in Exhibit 5.1)</font></a></font></div>
</td>
<td style="width: 4%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px"><font>&#xA0;</font></div>
</td>
</tr><tr style="background-color: #cceeff">
<td style="width: 10%">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px"><font style="font-size: 13px">&#xA0;24.1</font></div>
</td>
<td style="width: 2%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px"><font style="font-size: 13px">&#xA0;</font></div>
</td>
<td style="width: 84%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px"><font style="font-size: 13px">&#xA0;<font style="font-family: Times New Roman;">Power of Attorney (included on
signature page)</font><br></font></div>
</td>
<td style="width: 4%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px"><font><br></font></div>
</td>
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s-8
As
filed with the Securities and Exchange Commission on November 12,
2020
Registration
No. 333-
UNITED
STATES
SECURITIES
AND EXCHANGE COMMISSION
Washington,
D.C. 20549
FORM S-8
REGISTRATION
STATEMENT UNDER THE SECURITIES ACT OF 1933
Monopar
Therapeutics Inc.
(Exact name of
registrant as specified in its charter)
Delaware
(State or other
jurisdiction ofincorporation or organization)
32-0463781
(I.R.S.
EmployerIdentification No.)
1000
Skokie Blvd., Suite 350
Wilmette,
IL 60091
(Address of
principal executive offices) (Zip Code)
Monopar
Therapeutics Inc. 2016 Stock Incentive Plan
(Full title of the
plans)
Chandler
Robinson, MD
Chief
Executive Officer
1000
Skokie Blvd., Suite 350
Wilmette,
IL 60091
(Name and Address
of agent for service)
(847)
388-0349
(Telephone
number, including area code, of agent for service)
With
a copy to:
Robert
Rupp, Esq.
John J. Harrington
Baker
& Hostetler LLP
200
Civic Center Drive, Suite 1200
Columbus,
OH 43215
(614)
228-1541
Indicate by check
mark whether the registrant is a large accelerated filer, an
accelerated filer, a non-accelerated filer, or a smaller reporting
company.  See definitions of "large accelerated
filer," "accelerated filer" and "smaller
reporting company" in Rule 12b-2 of the Exchange
Act.  (Check one):
Large
accelerated filer ☐
Accelerated
filer   ☐
Non-accelerated
filer   ☐
Smaller Reporting
Company ☒
Emerging growth
company ☒
If an emerging
growth company, indicate by check mark if the registrant has
elected not to use the extended transition period for complying
with any new or revised financial accounting standards provided
pursuant to Section 7(a)(2)(B) of the Securities
Act.  ☒
CALCULATION OF REGISTRATION FEE
Title of Securities
to be Registered
Amount to
be Registered
(1)
Proposed
Maximum Offering Price Per Share
Proposed
Maximum Aggregate Offering Price
Amount of
Registration Fee
Common Stock,
$0.001 par value
1,500,000
(2)
$
4.435
$
6,652,500
(3)
$
726
(1)
Pursuant to Rule
416(a) under the Securities Act of 1933, as amended, this
Registration Statement shall also cover any additional shares of
common stock ("Common Stock") of Monopar Therapeutics
Inc. (the "Registrant") that become issuable under the
Registrant's 2016 Stock Incentive Plan (the
"Plan"), by reason of any stock dividend, stock split,
recapitalization or other similar transaction that increases the
number of the outstanding shares of the Registrant's common
stock.
(2)
Represents shares
of Common Stock reserved for future grant under the
Plan.
(3)
Estimated solely
for purposes of calculating the registration fee in accordance with
Rule 457(h) of the Securities Act of 1933, as amended, by averaging
the high and low sales prices of the Registrant's common
stock reported on the Nasdaq Capital Market as of a date (November
6, 2020) within five business days prior to filing this
Registration Statement.
REGISTRATION
OF ADDITIONAL SHARES PURSUANT TO GENERAL INSTRUCTION E
This
Registration Statement on Form S-8 (the "Registration
Statement") of Monopar Therapeutics Inc. (the
"Company" or the "Registrant") is being
filed pursuant to General Instruction E to Form S-8 under the
Securities Act of 1933, as amended, to register 1,500,000
additional shares of the Company's common stock, $0.001 par
value per share (the "Common Stock"), under the 2016
Stock Incentive Plan (the "Plan"). This Registration
Statement on Form S-8 hereby incorporates by reference the contents
of the Registrant's registration statement on Form S-8 filed
with the Securities and Exchange Commission (the
"Commission") on January 3, 2020 (Registration No.
333-235790).
PART II
INFORMATION
REQUIRED IN THE REGISTRATION STATEMENT
Item
3. Incorporation of Documents by Reference
The
following documents filed by the Registrant with the Commission are
incorporated herein by reference:
●
The
Registrant's Quarterly Report on
Form
10-Q
for the quarter ended September 30, 2020,
filed with the SEC on November 12, 2020;
●
The
Registrant's Quarterly Report on
Form
10-Q
for the
quarter ended June 30, 2020, filed with the SEC on August 6,
2020;
●
The
Registrant's Quarterly Report on
Form
10-Q
for the quarter ended March 31, 2020, filed with
the SEC on May 7, 2020;
●
The
Registrant's Annual Report on
Form
10-K
for the
year ended December 31, 2019, filed with the SEC on March 27, 2020;
and
●
The
Registrant's Current Reports on Form 8-K, filed with the SEC
on
January
7, 2020
,
January 13,
2020
,
June 15,
2020
,
June 16,
2020
,
to the extent
the information in such reports is filed and not
furnished.
All
reports and other documents filed by the Registrant after the date
hereof pursuant to Sections 13(a), 13(c), 14 and 15(d) of the
Securities Exchange Act of 1934, as amended, prior to the filing of
a post-effective amendment which indicates that all securities
offered hereby have been sold or which deregisters all securities
then remaining unsold, shall be deemed to be incorporated by
reference herein and to be part hereof from the date of filing of
such reports and documents. Any statement contained in a document
incorporated or deemed to be incorporated by reference herein shall
be deemed to be modified or superseded for the purposes of this
Registration Statement to the extent that a statement contained
herein or in any other subsequently filed document which also is or
is deemed to be incorporated by reference herein modifies or
supersedes such statement. Any statement so modified or superseded
shall not be deemed, except as so modified or superseded, to
constitute a part of this Registration Statement.
Item
8. Exhibits
Exhibit
Number
Description
5.1
Opinion of Legal
Counsel
10.1
Monopar Therapeutics Inc. 2016
Stock Incentive Plan (incorporated by reference to Appendix A to
the Registrant's DEF14A Proxy Statement (file number
001-39070), filed with the SEC on April 29,
2020)
23.1
Consent
of Independent
Registered Public Accounting Firm
23.2
Consent of Legal Counsel (included
in Exhibit 5.1)
24.1
Power of Attorney (included on
signature page)
S
IGNATURES
Pursuant to the requirements of the Securities Act
of 1933, as amended, the Registrant certifies that it has
reasonable grounds to believe that it meets all of the requirements
for filing on Form S-8 and has duly caused this Registration
Statement to be signed on its behalf by the undersigned, thereunto
duly authorized, in Wilmette, Illinois, on the
12th day
of November, 2020.
MONOPAR THERAPEUTICS INC.
By:
/s/ Chandler D.
Robinson
Chandler D.
Robinson
Chief Executive
Officer and Director
POWER OF ATTORNEY
KNOW
ALL PERSONS BY THESE PRESENTS, that each person whose signature
appears below constitutes and appoints Chandler D. Robinson,
his/her true and lawful attorney-in-fact and agent with full power
of substitution and re-substitution, for him/her and in his/her
name, place and stead, in any and all capacities to sign any or all
amendments (including, without limitation, post-effective
amendments) to this Registration Statement, any related
Registration Statement filed pursuant to Rule 462(b) under the
Securities Act of 1933 and any or all pre- or post-effective
amendments thereto, and to file the same, with all exhibits
thereto, and all other documents in connection therewith, with the
Securities and Exchange Commission, granting unto said
attorney-in-fact and agent, full power and authority to do and
perform each and every act and thing requisite and necessary to be
done in and about the premises, as fully for all intents and
purposes as he/she might or could do in person, hereby ratifying
and confirming that said attorney-in-fact and agent, or any
substitute or substitutes for him, may lawfully do or cause to be
done by virtue hereof.
Pursuant to the
requirements of the Securities Act of 1933, the following persons
in the capacities and on the dates indicated have signed this
Registration Statement below.
Signatures
Title
Date
/s/ Chandler D.
Robinson
November 12,
2020
Chandler D.
Robinson
Chief Executive
Officer and Director (Principal Executive Officer)
/s/ Kim R.
Tsuchimoto
November 12
,
2020
Kim R.
Tsuchimoto
Chief Financial
Officer (Principal Financial and Accounting Officer)
/s/ Andrew P.
Mazar
November
12
,
2020
Andrew P.
Mazar
Chief Scientific
Officer and Director
/s/ Christopher M.
Starr
November
12
,
2020
Christopher M.
Starr
Executive Chairman
of the Board and Director
/s/ Raymond W.
Anderson
November
12
,
2020
Raymond W.
Anderson
Director
/s/ Michael J.
Brown
November
12
,
2020
Michael J.
Brown
Director
/s/ Arthur J.
Klausner
November
12
,
2020
Arthur J.
Klausner
Director
EXHIBIT INDEX
Exhibit
Number
Description
5.1
Opinion of Legal
Counsel
10.1
Monopar Therapeutics Inc. 2016
Stock Incentive Plan (incorporated by reference to Appendix A to
the Registrant's
DEF14A
Proxy Statement (file number 001-39070), filed with the
SEC on April 29, 2020)
23.1
Consent
of Independent
Registered Public Accounting Firm
23.2
Consent of Legal Counsel (included
in Exhibit 5.1)
24.1
Power of Attorney (included on
signature page)