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<p style="margin-bottom:0pt;text-align:center;margin-top:0pt;text-indent:0%;font-weight:bold;font-size:11pt;font-family:Times New Roman;font-style:normal;text-transform:none;font-variant: normal;">As filed with the Securities and Exchange Commission on March 16, 2020</p>
<p style="text-align:right;margin-bottom:0pt;margin-top:0pt;text-indent:0%;font-weight:bold;font-size:11pt;font-family:Times New Roman;font-style:normal;text-transform:none;font-variant: normal;">Registration No. 333-</p>
<p style="margin-bottom:6pt;border-bottom:Double 2.25pt;padding-bottom:1pt;margin-top:0pt;text-indent:0%;font-family:Times New Roman;font-size:10pt;">&nbsp;</p>
<p style="margin-bottom:6pt;text-align:center;margin-top:0pt;text-indent:0%;font-size:16pt;font-weight:bold;font-family:Times New Roman;font-style:normal;text-transform:none;font-variant: normal;">UNITED STATES<br />SECURITIES AND EXCHANGE COMMISSION<br />Washington, D.C.&nbsp;&nbsp;20549</p>
<p style="margin-bottom:6pt;text-align:center;margin-top:0pt;text-indent:0%;font-size:16pt;font-weight:bold;font-family:Times New Roman;font-style:normal;text-transform:none;font-variant: normal;">FORM S-8</p>
<p style="margin-bottom:6pt;text-align:center;margin-top:0pt;text-indent:0%;font-size:16pt;font-weight:bold;font-family:Times New Roman;font-style:normal;text-transform:none;font-variant: normal;">REGISTRATION STATEMENT <br /><font style="font-style:italic;font-size:12pt;">UNDER<br />THE SECURITIES ACT OF 1933</font></p>
<p style="margin-bottom:6pt;text-align:center;margin-top:0pt;text-indent:0%;font-size:24pt;font-weight:bold;font-family:Times New Roman;font-style:normal;text-transform:none;font-variant: normal;">Iterum Therapeutics plc<font style="font-weight:normal;font-size:11pt;"><br />(Exact Name of Registrant as Specified in Its Charter)</font></p>
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<p style="text-align:center;margin-bottom:0pt;margin-top:0pt;margin-left:0pt;;text-indent:0pt;;font-weight:bold;font-size:11pt;font-family:Times New Roman;font-style:normal;text-transform:none;font-variant: normal;">98-1283148</p></td>
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<p style="text-align:center;margin-bottom:12pt;margin-top:0pt;margin-left:0pt;;text-indent:0pt;;font-size:11pt;font-family:Times New Roman;font-weight:normal;font-style:normal;text-transform:none;font-variant: normal;">(I.R.S. Employer Identification No.)</p></td>
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<p style="margin-bottom:0pt;text-align:center;margin-top:0pt;text-indent:0%;font-weight:bold;font-size:11pt;font-family:Times New Roman;font-style:normal;text-transform:none;font-variant: normal;"><a name="_cp_text_1_1"></a><br />Block 2 Floor 3, Harcourt Centre,<br />Harcourt Street,<br />Dublin 2,<br />Ireland<br /><font style="font-weight:normal;font-size:10pt;"><a name="_cp_text_1_1"></a>(Address of Principal Executive Offices) </font></p>
<p style="margin-bottom:0pt;text-align:center;margin-top:0pt;text-indent:0%;font-weight:bold;;font-size:10pt;font-weight:bold;">&nbsp;</p>
<p style="margin-bottom:0pt;text-align:center;margin-top:0pt;text-indent:0%;font-weight:normal;font-size:10pt;font-family:Times New Roman;font-style:normal;text-transform:none;font-variant: normal;"><a name="_cp_text_1_2"></a>Not applicable </p>
<p style="text-align:center;margin-bottom:12pt;margin-top:0pt;text-indent:0%;font-weight:normal;font-size:10pt;font-family:Times New Roman;font-style:normal;text-transform:none;font-variant: normal;">(Zip Code)<font style="font-size:11pt;"><br /></font><font style="font-weight:bold;font-size:11pt;"><br />Iterum Therapeutics plc 2018 Equity Incentive Plan<br /></font>(Full Title of the Plan)</p>
<p style="margin-bottom:0pt;text-align:center;margin-top:0pt;text-indent:0%;font-weight:bold;font-size:11pt;font-family:Times New Roman;font-style:normal;text-transform:none;font-variant: normal;"><a name="_cp_text_1_5"></a>Corey Fishman<br />President and Chief Executive Officer<br />200 South Wacker Dr., Suite 650<br />Chicago, IL 60606<br /><font style="font-weight:normal;font-size:10pt;">(Name <a name="_cp_text_1_5"></a>and Address of Agent For Service)</font></p>
<p style="margin-bottom:0pt;text-align:center;margin-top:0pt;text-indent:0%;font-family:Times New Roman;font-size:10pt;font-weight:bold;">&nbsp;</p>
<p style="text-align:center;margin-bottom:12pt;margin-top:0pt;text-indent:0%;font-weight:bold;font-size:11pt;font-family:Times New Roman;font-style:normal;text-transform:none;font-variant: normal;"><a name="_cp_text_4_6"></a><a name="_cp_text_1_7"></a>(312) 778-6070<br /><a name="_cp_text_1_7"></a><font style="font-weight:normal;font-size:10pt;">(Telephone Number, Including Area Code, of Agent For Service)</font></p>
<p style="text-align:center;margin-bottom:12pt;margin-top:0pt;text-indent:0%;font-style:italic;font-weight:bold;font-size:11pt;font-family:Times New Roman;text-transform:none;font-variant: normal;">Copies to:<br /><br /><font style="font-style:normal;">Brian A. Johnson, Esq. <br />Wilmer Cutler Pickering Hale and Dorr LLP<br />7 World Trade Center<br />250 Greenwich Street<br />New York, New York 10007<br />Telephone: (212) 230-8800<br />Fax: (212) 230-8888</font></p>
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<p style="text-align:left;margin-bottom:12pt;margin-top:0pt;text-indent:0%;font-weight:normal;font-size:11pt;font-family:Times New Roman;font-style:normal;text-transform:none;font-variant: normal;"><a name="_AEIOULastRenderedPageBreakAEIOU2"></a><font style="font-weight:normal;font-size:11pt;font-family:Times New Roman;font-style:normal;text-transform:none;font-variant: normal;">Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, a smaller reporting company or an emerging growth company. See the definitions of &#8220;lar</font><font style="font-weight:normal;font-size:11pt;font-family:Times New Roman;font-style:normal;text-transform:none;font-variant: normal;">ge accelerated filer,&#8221; &#8220;accelerated filer,&#8221; &#8220;smaller reporting company,&#8221; and &#8220;emerging growth company&#8221; in Rule 12b-2 of the Exchange Act.</font></p>
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<p style="text-align:left;margin-bottom:12pt;margin-top:0pt;margin-left:0pt;;text-indent:0pt;;font-weight:normal;font-size:11pt;font-family:Times New Roman;font-style:normal;text-transform:none;font-variant: normal;">Large accelerated filer <font style="font-size:12pt;font-family:'Times New Roman';">&#9744;</font><font style="font-size:12pt;"></font></a></p></td>
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<p style="text-align:left;margin-bottom:6pt;margin-top:0pt;margin-left:0pt;;text-indent:0pt;;font-weight:normal;font-size:11pt;font-family:Times New Roman;font-style:normal;text-transform:none;font-variant: normal;">Accelerated filer <font style="font-size:12pt;font-family:'Times New Roman';">&#9744;</font><font style="font-size:12pt;"></font></p></td>
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<p style="text-align:left;margin-bottom:12pt;margin-top:0pt;margin-left:0pt;;text-indent:0pt;;font-weight:normal;font-size:11pt;font-family:Times New Roman;font-style:normal;text-transform:none;font-variant: normal;">Non-accelerated filer <font style="font-size:12pt;font-family:'Times New Roman';">&#9746;</font><font style="font-size:12pt;"></font></p></td>
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<p style="text-align:left;margin-bottom:12pt;margin-top:0pt;margin-left:0pt;;text-indent:0pt;;font-weight:normal;font-size:11pt;font-family:Times New Roman;font-style:normal;text-transform:none;font-variant: normal;"><a name="Check1"></a><a name="Check1"></a>Smaller reporting company <font style="font-size:12pt;font-family:'Times New Roman';">&#9746;</font><font style="font-size:12pt;"></font></p></td>
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<p style="text-align:left;margin-bottom:12pt;margin-top:0pt;margin-left:0pt;;text-indent:0pt;;font-family:Times New Roman;font-size:10pt;font-weight:bold;">&nbsp;</p></td>
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<p style="text-align:left;margin-bottom:12pt;margin-top:0pt;margin-left:0pt;;text-indent:0pt;;font-weight:normal;font-size:11pt;font-family:Times New Roman;font-style:normal;text-transform:none;font-variant: normal;">Emerging growth company <font style="font-size:12pt;font-family:'Times New Roman';">&#9746;</font><font style="font-size:12pt;"><br /></font></p></td>
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<p style="text-align:left;margin-bottom:6pt;margin-top:0pt;text-indent:0%;font-weight:normal;font-size:11pt;font-family:Times New Roman;font-style:normal;text-transform:none;font-variant: normal;">If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 7(a)(2)(B) of the Securities Act.&nbsp;&nbsp;<font style="font-size:12pt;font-family:'Times New Roman';">&#9746;</font><font style="font-size:12pt;"></font></a></p>
<p style="text-align:center;margin-bottom:12pt;margin-top:0pt;text-indent:0%;font-family:Times New Roman;font-size:10pt;font-weight:bold;">&nbsp;</p>
<p style="text-align:center;margin-bottom:12pt;margin-top:0pt;text-indent:0%;font-weight:bold;font-size:11pt;font-family:Times New Roman;font-style:normal;text-transform:none;font-variant: normal;">CALCULATION OF REGISTRATION FEE</p>
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<p style="text-align:center;margin-bottom:0pt;margin-top:0pt;margin-left:0pt;;text-indent:0pt;;font-weight:bold;font-size:10pt;font-family:Times New Roman;font-style:normal;text-transform:none;font-variant: normal;">Title of Securities to be Registered</p></td>
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<p style="text-align:center;margin-bottom:0pt;margin-top:0pt;margin-left:0pt;;text-indent:0pt;;font-weight:bold;font-size:10pt;font-family:Times New Roman;font-style:normal;text-transform:none;font-variant: normal;">Amount to be Registered(1)</p></td>
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<p style="text-align:center;margin-bottom:0pt;margin-top:0pt;margin-left:0pt;;text-indent:0pt;;font-weight:bold;font-size:10pt;font-family:Times New Roman;font-style:normal;text-transform:none;font-variant: normal;">Proposed Maximum Offering Price Per Share</p></td>
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<p style="text-align:center;margin-bottom:0pt;margin-top:0pt;margin-left:0pt;;text-indent:0pt;;font-weight:bold;font-size:10pt;font-family:Times New Roman;font-style:normal;text-transform:none;font-variant: normal;">Proposed Maximum Aggregate Offering Price</p></td>
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<p style="text-align:center;margin-bottom:0pt;margin-top:0pt;margin-left:0pt;;text-indent:0pt;;font-weight:bold;font-size:10pt;font-family:Times New Roman;font-style:normal;text-transform:none;font-variant: normal;">Amount of Registration Fee</p></td>
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<p style="margin-bottom:0pt;margin-top:0pt;margin-left:0pt;;text-indent:0pt;;color:#000000;font-size:11pt;font-family:Times New Roman;font-weight:normal;font-style:normal;text-transform:none;font-variant: normal;"><font style="Background-color:#FFFFFF;">Ordinary Shares, par value $0.01 per share</font><font style="color:#000000;"> </font></p></td>
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<p style="margin-bottom:0pt;margin-top:0pt;margin-left:0pt;;text-indent:0pt;;font-family:Times New Roman;font-size:10pt;">&nbsp;</p>
<p style="text-align:center;margin-bottom:0pt;margin-top:0pt;margin-left:0pt;;text-indent:0pt;;color:#000000;font-size:11pt;font-family:Times New Roman;font-weight:normal;font-style:normal;text-transform:none;font-variant: normal;"><font style="Background-color:#FFFFFF;">594,758 shares(2)</font></p></td>
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<p style="margin-bottom:0pt;margin-top:0pt;margin-left:0pt;;text-indent:0pt;;font-family:Times New Roman;font-size:10pt;">&nbsp;</p>
<p style="text-align:center;margin-bottom:0pt;margin-top:0pt;margin-left:0pt;;text-indent:0pt;;color:#000000;font-size:11pt;font-family:Times New Roman;font-weight:normal;font-style:normal;text-transform:none;font-variant: normal;"><font style="Background-color:#FFFFFF;">$1.87(3)</font></p></td>
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<p style="margin-bottom:0pt;margin-top:0pt;margin-left:0pt;;text-indent:0pt;;font-family:Times New Roman;font-size:10pt;">&nbsp;</p>
<p style="text-align:center;margin-bottom:0pt;margin-top:0pt;margin-left:0pt;;text-indent:0pt;;color:#000000;font-size:11pt;font-family:Times New Roman;font-weight:normal;font-style:normal;text-transform:none;font-variant: normal;"><font style="Background-color:#FFFFFF;">$1,112,198(3)</font></p></td>
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<p style="margin-bottom:0pt;margin-top:0pt;margin-left:0pt;;text-indent:0pt;;font-family:Times New Roman;font-size:10pt;">&nbsp;</p>
<p style="text-align:center;margin-bottom:0pt;margin-top:0pt;margin-left:0pt;;text-indent:0pt;;color:#000000;font-size:11pt;font-family:Times New Roman;font-weight:normal;font-style:normal;text-transform:none;font-variant: normal;"><font style="Background-color:#FFFFFF;">$144.37</font></p></td>
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<p style="margin-bottom:12pt;margin-top:0pt;font-weight:normal;font-style:normal;text-transform:none;font-variant: normal;font-family:Times New Roman;font-size:11pt;">&nbsp;</p></td>
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<p style="margin-bottom:12pt;margin-top:0pt;font-size:11pt;font-family:Times New Roman;font-weight:normal;font-style:normal;text-transform:none;font-variant: normal;"><font style="font-size:11pt;font-family:Times New Roman;font-weight:normal;font-style:normal;text-transform:none;font-variant: normal;">(1)</font></p></td>
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<p style="margin-bottom:12pt;margin-top:0pt;font-weight:normal;font-style:normal;text-transform:none;font-variant: normal;font-family:Times New Roman;font-size:11pt;">Pursuant to Rule 416(a) promulgated under the Securities Act of 1933, as amended (the &#8220;Securities Act&#8221;), this Registration Statement shall also cover any additional ordinary shares of the Registrant (&#8220;Ordinary Shares&#8221;) that become issuable under the Registrant&#8217;s 2018 Equity Incentive Plan by reason of any stock dividend, stock split, recapitalization, or other similar transaction effected that results in an increase to the number of the Registrant&#8217;s outstanding Ordinary Shares.</p></td></tr></table></div>
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<p style="margin-top:6pt;margin-bottom:12pt;font-weight:normal;font-style:normal;text-transform:none;font-variant: normal;font-family:Times New Roman;font-size:11pt;">&nbsp;</p></td>
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<p style="margin-top:6pt;margin-bottom:12pt;font-size:11pt;font-family:Times New Roman;font-weight:normal;font-style:normal;text-transform:none;font-variant: normal;"><font style="font-size:11pt;font-family:Times New Roman;font-weight:normal;font-style:normal;text-transform:none;font-variant: normal;">(2)</font></p></td>
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<p style="margin-top:6pt;margin-bottom:12pt;font-weight:normal;font-style:normal;text-transform:none;font-variant: normal;font-family:Times New Roman;font-size:11pt;">Represents additional Ordinary Shares reserved for future issuance under the Registrant&#8217;s 2018 Equity Incentive Plan as a result of an annual increase.</p></td></tr></table></div>
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<p style="margin-top:6pt;margin-bottom:12pt;font-weight:normal;font-style:normal;text-transform:none;font-variant: normal;font-family:Times New Roman;font-size:11pt;">&nbsp;</p></td>
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<p style="margin-top:6pt;margin-bottom:12pt;font-size:11pt;font-family:Times New Roman;font-weight:normal;font-style:normal;text-transform:none;font-variant: normal;"><font style="font-size:11pt;font-family:Times New Roman;font-weight:normal;font-style:normal;text-transform:none;font-variant: normal;">(3)</font></p></td>
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<p style="margin-top:6pt;margin-bottom:12pt;font-weight:normal;font-style:normal;text-transform:none;font-variant: normal;font-family:Times New Roman;font-size:11pt;"><a name="_cp_text_1_9"></a><a name="_cp_text_28_10"></a>Estimated solely for the purpose of calculating the registration fee pursuant to Rules 457(c) and 457(h) of the Securities Act. The price per share and aggregate offering price are calculated on the basis of $1.87, the average of the high and low sale prices of the Ordinary Shares as reported on the Nasdaq Global Market on March 13<a name="_cp_text_1_9"></a>, 2020<a name="_cp_text_28_10"></a>, in accordance with Rule 457(c) under the Securities Act.</p></td></tr></table></div>
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<p style="margin-bottom:0pt;margin-top:0pt;text-indent:0%;font-family:Times New Roman;font-size:10pt;">&nbsp;</p>
<p style="text-align:center;margin-bottom:12pt;margin-top:0pt;text-indent:0%;font-weight:bold;font-size:11pt;font-family:Times New Roman;font-style:normal;text-transform:none;font-variant: normal;"><a name="_AEIOULastRenderedPageBreakAEIOU3"></a><font style="font-weight:bold;font-size:11pt;font-family:Times New Roman;font-style:normal;text-transform:none;font-variant: normal;">EXPLANATORY NOTE</font></p>
<p style="text-align:left;margin-bottom:12pt;margin-top:0pt;text-indent:0%;font-weight:normal;font-size:11pt;font-family:Times New Roman;font-style:normal;text-transform:none;font-variant: normal;"><a name="_cp_text_1_14"></a><a name="_cp_text_1_16"></a><a name="_cp_text_1_18"></a><a name="_cp_text_1_24"></a><a name="_cp_text_1_26"></a><a name="_cp_text_1_30"></a><a name="_cp_text_1_32"></a>This Registration Statement on Form S-8, relating to the 2018 Equity Incentive Plan of Iterum Therapeutics plc (the &#8220;Registrant&#8221;), is being filed for the purpose of registering additional securities of the same class as other securities for which a Registration Statement on Form S-8 has previously been filed and is effective.&nbsp;&nbsp;Accordi<a name="_cp_text_1_14"></a>ngly, this Registration Statement hereby incorporates by reference the contents of the following <a name="_cp_text_1_16"></a>Registration Statements <a name="_cp_text_1_18"></a>on Form S-8 previously <a name="_cp_text_1_24"></a>filed with the Securities and Exchange Commission (the &#8220;Commission&#8221;) by the Registrant, except in each case for <a name="_cp_text_1_26"></a>Item 8. <a name="_cp_text_1_30"></a>Exhibits, with respect to which the Exhibit Index included in Part II of this Registration Statement <a name="_cp_text_1_32"></a>is incorporated herein by reference:</p>
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<p style="text-align:left;margin-bottom:12pt;margin-top:0pt;font-weight:normal;font-family:'Times New Roman';font-size:11pt;font-style:normal;text-transform:none;font-variant: normal;"><font style="font-weight:normal;font-family:'Times New Roman';font-size:11pt;font-style:normal;text-transform:none;font-variant: normal;">&#x2022;</font></p></td>
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<p style="text-align:left;margin-bottom:12pt;margin-top:0pt;font-weight:normal;font-style:normal;text-transform:none;font-variant: normal;font-family:'Times New Roman';font-size:11pt;"><a name="_cp_blt_1_38"></a><a name="_cp_text_1_33"></a><a name="_cp_text_4_34"></a><a name="_cp_text_1_35"></a><a name="_cp_text_4_36"></a><a name="_cp_text_4_37"></a><a name="_cp_text_1_39"></a><a href="http://www.sec.gov/Archives/edgar/data/1659323/000119312518175451/d528754ds8.htm"><font style="text-decoration:underline;font-family:Times New Roman;">Registration St<a name="_cp_text_4_34"></a>atement on Form S-8<a name="_cp_text_1_35"></a>, File No. 333-225236, <a name="_cp_text_4_36"></a>filed with the Commission on May 25, 2018 by the Registrant, <a name="_cp_text_4_37"></a>relating to the Registrant&#8217;s 2015 Equity Incentive Plan <a name="_cp_text_1_39"></a>and 2018 Equity Incentive Plan.</font></a></p></td></tr></table></div>
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<p style="text-align:left;margin-bottom:12pt;margin-top:0pt;font-weight:normal;font-style:normal;text-transform:none;font-variant: normal;font-family:'Times New Roman';font-size:11pt;">&nbsp;</p></td>
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<p style="text-align:left;margin-bottom:12pt;margin-top:0pt;font-weight:normal;font-family:'Times New Roman';font-size:11pt;font-style:normal;text-transform:none;font-variant: normal;"><font style="font-weight:normal;font-family:'Times New Roman';font-size:11pt;font-style:normal;text-transform:none;font-variant: normal;">&#x2022;</font></p></td>
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<p style="text-align:left;margin-bottom:12pt;margin-top:0pt;font-weight:normal;font-style:normal;text-transform:none;font-variant: normal;font-family:'Times New Roman';font-size:11pt;"><a name="_cp_blt_1_40"></a><a name="_cp_text_1_41"></a><a href="http://www.sec.gov/Archives/edgar/data/1659323/000119312519085409/d709396ds8.htm"><font style="text-decoration:underline;font-family:Times New Roman;">Registration Statement on Form S-8, File No. 333-230496, filed with the Commission on March 25, 2019 by the Registrant, relating to the Registrant&#8217;s 2018 Equity Incentive Plan</font></a><font style="font-weight:normal;font-size:11pt;font-family:Times New Roman;font-style:normal;text-transform:none;font-variant: normal;">.</font></p></td></tr></table></div>
<p style="text-align:center;margin-bottom:0pt;margin-top:0pt;text-indent:0%;font-weight:bold;font-size:11pt;font-family:Times New Roman;font-style:normal;text-transform:none;font-variant: normal;">PART II</p>
<p style="text-align:center;margin-bottom:0pt;margin-top:0pt;text-indent:0%;font-family:Times New Roman;font-size:10pt;">&nbsp;</p>
<p style="text-align:center;margin-bottom:0pt;margin-top:0pt;text-indent:0%;font-weight:bold;font-size:11pt;font-family:Times New Roman;font-style:normal;text-transform:none;font-variant: normal;">INFORMATION REQUIRED IN THE REGISTRATION STATEMENT</p>
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<p style="margin-bottom:0pt;margin-top:0pt;text-indent:0%;font-weight:bold;font-size:11pt;font-family:Times New Roman;font-style:normal;text-transform:none;font-variant: normal;"><a name="_cp_text_28_42"></a>ITEM 8. <font style="margin-left:36pt;"><a name="_cp_text_28_42"></a>EXHIBITS</font><font style="text-decoration:underline;"> <br /></font></p>
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<p style="margin-bottom:0pt;margin-top:0pt;margin-left:0pt;;text-indent:0pt;;font-weight:bold;color:#000000;font-size:11pt;font-family:Times New Roman;font-style:normal;text-transform:none;font-variant: normal;">Exhibit<font style="text-decoration:underline;"><br />Number</font></p></td>
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<p style="margin-bottom:2pt;margin-top:2pt;margin-left:0pt;;text-indent:0pt;;font-weight:bold;color:#000000;font-size:11pt;font-family:Times New Roman;font-style:normal;text-transform:none;font-variant: normal;"><font style="text-decoration:underline;">Description</font></p></td>
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<p style="margin-bottom:0pt;margin-top:0pt;margin-left:0pt;;text-indent:0pt;;font-size:11pt;font-family:Times New Roman;font-weight:normal;font-style:normal;text-transform:none;font-variant: normal;"><a href="http://www.sec.gov/Archives/edgar/data/1659323/000119312518178562/d596711dex31.htm"><font style="text-decoration:underline;">4.1(1)</font></a></p></td>
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<p style="margin-bottom:0pt;margin-top:0pt;margin-left:0pt;;text-indent:0pt;;font-size:11pt;font-family:Times New Roman;font-weight:normal;font-style:normal;text-transform:none;font-variant: normal;"><a href="http://www.sec.gov/Archives/edgar/data/1659323/000119312518178562/d596711dex31.htm"><font style="text-decoration:underline;">Constitution of the Registrant</font></a></p></td>
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<p style="margin-bottom:0pt;margin-top:0pt;margin-left:0pt;;text-indent:0pt;;font-size:11pt;font-family:Times New Roman;font-weight:normal;font-style:normal;text-transform:none;font-variant: normal;"><a href="itrm-ex51_59.htm"><font style="text-decoration:underline;">5.1</font></a></p></td>
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<p style="margin-bottom:0pt;margin-top:0pt;margin-left:0pt;;text-indent:0pt;;font-size:11pt;font-family:Times New Roman;font-weight:normal;font-style:normal;text-transform:none;font-variant: normal;"><a href="itrm-ex51_59.htm"><font style="text-decoration:underline;">Opinion of A&amp;L Goodbody</font></a></p></td>
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<p style="margin-bottom:0pt;margin-top:0pt;margin-left:0pt;;text-indent:0pt;;font-size:11pt;font-family:Times New Roman;font-weight:normal;font-style:normal;text-transform:none;font-variant: normal;"><a href="itrm-ex51_59.htm"><font style="text-decoration:underline;">23.1</font></a></p></td>
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<p style="margin-bottom:0pt;margin-top:0pt;margin-left:0pt;;text-indent:0pt;;font-size:11pt;font-family:Times New Roman;font-weight:normal;font-style:normal;text-transform:none;font-variant: normal;"><a href="itrm-ex51_59.htm"><font style="text-decoration:underline;">Consent of A&amp;L Goodbody (included in Exhibit 5.1)</font></a></p></td>
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<p style="margin-bottom:0pt;margin-top:0pt;margin-left:0pt;;text-indent:0pt;;font-size:11pt;font-family:Times New Roman;font-weight:normal;font-style:normal;text-transform:none;font-variant: normal;"><a href="itrm-ex232_58.htm"><font style="text-decoration:underline;">23.2</font></a></p></td>
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<p style="margin-bottom:0pt;margin-top:0pt;margin-left:0pt;;text-indent:0pt;;font-size:11pt;font-family:Times New Roman;font-weight:normal;font-style:normal;text-transform:none;font-variant: normal;"><a href="itrm-ex232_58.htm"><font style="text-decoration:underline;">Consent of KPMG, Independent Registered Public Accounting Firm</font></a></p></td>
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<p style="margin-bottom:0pt;margin-top:0pt;margin-left:0pt;;text-indent:0pt;;font-size:11pt;font-family:Times New Roman;font-weight:normal;font-style:normal;text-transform:none;font-variant: normal;"><a href="#POA"><font style="text-decoration:underline;">24.1</font></a></p></td>
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<p style="margin-bottom:0pt;margin-top:0pt;margin-left:0pt;;text-indent:0pt;;font-size:11pt;font-family:Times New Roman;font-weight:normal;font-style:normal;text-transform:none;font-variant: normal;"><a href="#POA"><font style="text-decoration:underline;">Power of attorney (included on the signature pages of this registration statement)</font></a></p></td>
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<p style="margin-bottom:0pt;margin-top:0pt;margin-left:0pt;;text-indent:0pt;;font-size:11pt;font-family:Times New Roman;font-weight:normal;font-style:normal;text-transform:none;font-variant: normal;"><a href="http://www.sec.gov/Archives/edgar/data/1659323/000119312518164732/d522368dex106.htm"><font style="text-decoration:underline;">99.1(2)</font></a></p></td>
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<p style="margin-bottom:0pt;margin-top:0pt;margin-left:0pt;;text-indent:0pt;;font-size:11pt;font-family:Times New Roman;font-weight:normal;font-style:normal;text-transform:none;font-variant: normal;"><a href="http://www.sec.gov/Archives/edgar/data/1659323/000119312518164732/d522368dex106.htm"><font style="text-decoration:underline;">2018 Equity Incentive Plan</font></a></p></td>
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<p style="margin-bottom:12pt;margin-top:5pt;text-indent:0%;color:#000000;font-size:11pt;font-family:Times New Roman;font-weight:normal;font-style:normal;text-transform:none;font-variant: normal;"><font style="Background-color:#FFFFFF;">____________</font></p>
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<p style="margin-bottom:12pt;margin-top:0pt;color:#000000;font-size:11pt;font-family:Times New Roman;font-weight:normal;font-style:normal;text-transform:none;font-variant: normal;"><font style="Background-color:#FFFFFF;color:#000000;font-size:11pt;font-family:Times New Roman;font-weight:normal;font-style:normal;text-transform:none;font-variant: normal;">(1)</font></p></td>
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<p style="margin-bottom:12pt;margin-top:0pt;color:#000000;font-weight:normal;font-style:normal;text-transform:none;font-variant: normal;font-family:Times New Roman;font-size:11pt;"><a name="_Hlk34831760"></a><font style="Background-color:#FFFFFF;"><a name="_Hlk34831760"></a><a href="http://www.sec.gov/Archives/edgar/data/1659323/000119312518178562/d596711dex31.htm"></font><a href="http://www.sec.gov/Archives/edgar/data/1659323/000119312518178562/d596711dex31.htm"><font style="Background-color:#FFFFFF;text-decoration:underline;">Previously filed as Exhibit 3.1 to the Registrant&#8217;s Current Report on Form 8-K (File No. 001-38503), filed with the Commission on May 30, 2018, and incorporated by reference herein.</font></a></a><font style="Background-color:#FFFFFF;"></font></p></td></tr></table></div>
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<p style="margin-bottom:12pt;margin-top:0pt;color:#000000;font-size:11pt;font-family:Times New Roman;font-weight:normal;font-style:normal;text-transform:none;font-variant: normal;"><font style="Background-color:#FFFFFF;color:#000000;font-size:11pt;font-family:Times New Roman;font-weight:normal;font-style:normal;text-transform:none;font-variant: normal;">(2)</font></p></td>
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<p style="margin-bottom:12pt;margin-top:0pt;color:#000000;font-weight:normal;font-style:normal;text-transform:none;font-variant: normal;font-family:Times New Roman;font-size:11pt;"><font style="Background-color:#FFFFFF;"></font><a href="http://www.sec.gov/Archives/edgar/data/1659323/000119312518164732/d522368dex106.htm"><font style="Background-color:#FFFFFF;text-decoration:underline;">Previously filed as Exhibit 10.6 to Amendment No. 2 to the Registrant&#8217;s registration statement on Form S-1 (File No. 333-224582), filed with the Commission on May 16, 2018, and incorporated by reference herein.</font></a></p></td></tr></table></div>
<p style="text-align:center;margin-bottom:12pt;margin-top:0pt;text-indent:0%;font-weight:normal;font-size:11pt;font-family:Times New Roman;font-style:normal;text-transform:none;font-variant: normal;"><a name="_AEIOULastRenderedPageBreakAEIOU4"></a><br /></p>
<p style="margin-top:12pt;margin-bottom:0pt;text-indent:0%;font-family:Times New Roman;font-size:10pt;">&nbsp;</p>
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<p style="margin-bottom:0pt;margin-top:0pt;text-indent:0%;font-family:Times New Roman;font-size:10pt;">&nbsp;</p>
<p style="text-align:center;margin-bottom:12pt;margin-top:0pt;font-weight:normal;font-size:11pt;font-family:Times New Roman;font-style:normal;text-transform:none;font-variant: normal;"><font style="font-weight:bold;">SIGNATURES</font></p>
<p style="margin-bottom:12pt;margin-top:0pt;text-indent:7.69%;font-size:11pt;font-family:Times New Roman;font-weight:normal;font-style:normal;text-transform:none;font-variant: normal;"><a name="_cp_text_1_47"></a><a name="_cp_text_1_49"></a>Pursuant to the requirements of the Securities Act of 1933, the registrant certifies that it has reasonable grounds to believe that it meets all of the requirements for filing on Form S-8 and has duly caused this registration statement to be signed on its behalf by the un<a name="_cp_text_1_47"></a>dersigned, thereunto duly authorized, in the City of Chicago, State of Illinois, on this 16<sup style="font-size:85%;line-height:120%;vertical-align:top">th</sup><a name="_cp_text_1_49"></a> day of March, 2020.</p>
<p style="margin-bottom:0pt;margin-top:0pt;margin-left:46.15%;text-indent:0%;font-size:11pt;font-family:Times New Roman;font-weight:normal;font-style:normal;text-transform:none;font-variant: normal;">ITERUM THERAPEUTICS PLC</p>
<p style="margin-bottom:0pt;margin-top:0pt;margin-left:46.15%;text-indent:0%;font-family:Times New Roman;font-size:10pt;">&nbsp;</p>
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<p style="margin-bottom:0pt;margin-top:0pt;font-weight:normal;font-style:normal;text-transform:none;font-variant: normal;font-family:Times New Roman;font-size:11pt;">&nbsp;</p></td>
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<p style="margin-bottom:0pt;margin-top:0pt;font-size:11pt;font-family:Times New Roman;font-weight:normal;font-style:normal;text-transform:none;font-variant: normal;"><font style="font-size:11pt;font-family:Times New Roman;font-weight:normal;font-style:normal;text-transform:none;font-variant: normal;">By:</font></p></td>
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<p style="margin-bottom:0pt;margin-top:0pt;font-weight:normal;font-style:normal;text-transform:none;font-variant: normal;font-family:Times New Roman;font-size:11pt;"><font style="text-decoration:underline;Background-color:#FFFFFF;color:#000000;">/s/Corey N. Fishman&nbsp;&nbsp;</font><font style="Background-color:#FFFFFF;color:#000000;"><br />Corey N. Fishman</font></p></td></tr></table></div>
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<p style="margin-bottom:0pt;margin-top:0pt;color:#000000;font-weight:normal;font-style:normal;text-transform:none;font-variant: normal;font-family:Times New Roman;font-size:11pt;">&nbsp;</p></td>
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<p style="margin-bottom:0pt;margin-top:0pt;color:#000000;font-size:11pt;font-family:Times New Roman;font-weight:normal;font-style:normal;text-transform:none;font-variant: normal;"></p></td>
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<p style="margin-bottom:0pt;margin-top:0pt;color:#000000;font-weight:normal;font-style:normal;text-transform:none;font-variant: normal;font-family:Times New Roman;font-size:11pt;"><font style="Background-color:#FFFFFF;">President and Chief Executive Officer</font><font style="color:#000000;"> </font></p></td></tr></table></div>
<p style="margin-bottom:0pt;margin-top:0pt;margin-left:46.15%;text-indent:0%;font-family:Times New Roman;font-size:10pt;">&nbsp;</p>
<p style="margin-bottom:0pt;margin-top:0pt;margin-left:46.15%;text-indent:0%;font-family:Times New Roman;font-size:10pt;">&nbsp;</p>
<p style="text-align:center;margin-bottom:12pt;margin-top:0pt;text-indent:0%;font-weight:bold;font-size:11pt;font-family:Times New Roman;font-style:normal;text-transform:none;font-variant: normal;"><a name="POA"></a><a name="POA"></a>POWER OF ATTORNEY AND SIGNATURES</p>
<p style="margin-bottom:12pt;margin-top:0pt;text-indent:7.69%;font-size:11pt;font-family:Times New Roman;font-weight:normal;font-style:normal;text-transform:none;font-variant: normal;">We, the undersigned officers and directors of Iterum Therapeutics plc, hereby severally constitute and appoint Corey N. Fishman and Judith M. Matthews, and each of them singly, our true and lawful attorneys with full power to them, and each of them singly, to sign for us and in our names in the capacities indicated below, the registration statement on Form S-8 filed herewith and any and all subsequent amendments to said registration statement, and generally to do all such things in our names and on our behalf in our capacities as officers and directors to enable Iterum Therapeutics plc to comply with the provisions of the Securities Act of 1933,&nbsp;&nbsp;and all requirements of the Securities and Exchange Commission, hereby ratifying and confirming our signatures as they may be signed by our said attorneys, or any of them, to said registration statement and any and all amendments thereto.</p>
<p style="margin-bottom:12pt;margin-top:0pt;text-indent:7.69%;font-size:11pt;font-family:Times New Roman;font-weight:normal;font-style:normal;text-transform:none;font-variant: normal;">Pursuant to the requirements of the Securities Act of 1933, this registration statement has been signed by the following persons in the capacities and on the dates indicated.</p>
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<p style="text-align:center;margin-bottom:0pt;margin-top:0pt;margin-left:0pt;;text-indent:0pt;;font-weight:bold;font-size:11pt;font-family:Times New Roman;font-style:normal;text-transform:none;font-variant: normal;"><font style="text-decoration:underline;">Signature</font></p></td>
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<p style="text-align:center;margin-bottom:0pt;margin-top:0pt;margin-left:0pt;;text-indent:0pt;;font-weight:bold;font-size:11pt;font-family:Times New Roman;font-style:normal;text-transform:none;font-variant: normal;"><font style="text-decoration:underline;">Title</font></p></td>
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<p style="text-align:center;margin-bottom:0pt;margin-top:0pt;margin-left:0pt;;text-indent:0pt;;font-weight:bold;font-size:11pt;font-family:Times New Roman;font-style:normal;text-transform:none;font-variant: normal;"><font style="text-decoration:underline;">Date</font></p></td>
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<p style="margin-top:24pt;margin-bottom:0pt;margin-left:0pt;;text-indent:0pt;;color:#000000;font-size:11pt;font-family:Times New Roman;font-weight:normal;font-style:normal;text-transform:none;font-variant: normal;"><font style="Background-color:#FFFFFF;text-decoration:underline;">/s/Corey N. Fishman&nbsp;&nbsp;</font><font style="Background-color:#FFFFFF;"><br />Corey N. Fishman</font></p></td>
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<p style="margin-top:24pt;margin-bottom:0pt;margin-left:0pt;;text-indent:0pt;;color:#000000;font-size:11pt;font-family:Times New Roman;font-weight:normal;font-style:normal;text-transform:none;font-variant: normal;"><font style="Background-color:#FFFFFF;">President, Chief Executive Officer and Director (Principal Executive Officer)</font></p></td>
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<p style="margin-top:24pt;margin-bottom:0pt;margin-left:19.15pt;;text-indent:0pt;;color:#000000;font-size:11pt;font-family:Times New Roman;font-weight:normal;font-style:normal;text-transform:none;font-variant: normal;"><font style="Background-color:#FFFFFF;">March 16, </font><font style="color:#000000;">2020</font></p></td>
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<p style="margin-top:24pt;margin-bottom:0pt;margin-left:0pt;;text-indent:0pt;;color:#000000;font-size:11pt;font-family:Times New Roman;font-weight:normal;font-style:normal;text-transform:none;font-variant: normal;"><font style="Background-color:#FFFFFF;text-decoration:underline;">/s/Judith M. Matthews</font><font style="Background-color:#FFFFFF;"><br />Judith M. Matthews</font></p></td>
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<p style="margin-top:24pt;margin-bottom:0pt;margin-left:0pt;;text-indent:0pt;;color:#000000;font-size:11pt;font-family:Times New Roman;font-weight:normal;font-style:normal;text-transform:none;font-variant: normal;"><font style="Background-color:#FFFFFF;">Chief Financial Officer</font><font style="color:#000000;"> </font><font style="Background-color:#FFFFFF;">(Principal Financial and Accounting Officer)</font></p></td>
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<p style="margin-top:24pt;margin-bottom:0pt;margin-left:19.15pt;;text-indent:0pt;;color:#000000;font-size:11pt;font-family:Times New Roman;font-weight:normal;font-style:normal;text-transform:none;font-variant: normal;"><font style="Background-color:#FFFFFF;">March 16, </font><font style="color:#000000;">2020</font></p></td>
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<p style="margin-top:24pt;margin-bottom:0pt;margin-left:0pt;;text-indent:0pt;;color:#000000;font-size:11pt;font-family:Times New Roman;font-weight:normal;font-style:normal;text-transform:none;font-variant: normal;"><font style="Background-color:#FFFFFF;text-decoration:underline;">/s/ Brenton K. Ahrens</font><font style="Background-color:#FFFFFF;"><br />Brenton K. Ahrens</font></p></td>
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<p style="margin-top:24pt;margin-bottom:0pt;margin-left:0pt;;text-indent:0pt;;color:#000000;font-size:11pt;font-family:Times New Roman;font-weight:normal;font-style:normal;text-transform:none;font-variant: normal;"><font style="Background-color:#FFFFFF;">Director</font></p></td>
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<p style="margin-top:24pt;margin-bottom:0pt;margin-left:19.15pt;;text-indent:0pt;;color:#000000;font-size:11pt;font-family:Times New Roman;font-weight:normal;font-style:normal;text-transform:none;font-variant: normal;"><font style="Background-color:#FFFFFF;">March 16, </font><font style="color:#000000;">2020</font></p></td>
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<p style="margin-top:24pt;margin-bottom:0pt;margin-left:0pt;;text-indent:0pt;;color:#000000;font-size:11pt;font-family:Times New Roman;font-weight:normal;font-style:normal;text-transform:none;font-variant: normal;"><font style="Background-color:#FFFFFF;">Director</font></p></td>
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<p style="margin-top:24pt;margin-bottom:0pt;margin-left:19.15pt;;text-indent:0pt;;color:#000000;font-size:11pt;font-family:Times New Roman;font-weight:normal;font-style:normal;text-transform:none;font-variant: normal;"><font style="Background-color:#FFFFFF;">March 16, </font><font style="color:#000000;">2020</font></p></td>
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<p style="margin-top:12pt;margin-bottom:0pt;margin-left:0pt;;text-indent:0pt;;font-family:Times New Roman;font-size:10pt;">&nbsp;</p>
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<p style="margin-bottom:0pt;margin-top:0pt;margin-left:0pt;;text-indent:0pt;;font-family:Times New Roman;font-size:10pt;">&nbsp;</p>
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<p style="margin-top:24pt;margin-bottom:0pt;margin-left:0pt;;text-indent:0pt;;color:#000000;font-size:11pt;font-family:Times New Roman;font-weight:normal;font-style:normal;text-transform:none;font-variant: normal;"><font style="Background-color:#FFFFFF;">Director</font></p></td>
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<p style="margin-top:24pt;margin-bottom:0pt;margin-left:19.15pt;;text-indent:0pt;;color:#000000;font-size:11pt;font-family:Times New Roman;font-weight:normal;font-style:normal;text-transform:none;font-variant: normal;"><font style="Background-color:#FFFFFF;">March 16, </font><font style="color:#000000;">2020</font></p></td>
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<p style="margin-top:24pt;margin-bottom:0pt;margin-left:0pt;;text-indent:0pt;;color:#000000;font-size:11pt;font-family:Times New Roman;font-weight:normal;font-style:normal;text-transform:none;font-variant: normal;"><font style="Background-color:#FFFFFF;text-decoration:underline;">/s/ Ronald M. Hunt</font><font style="Background-color:#FFFFFF;"><br />Ronald M. Hunt</font></p></td>
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<p style="margin-top:24pt;margin-bottom:0pt;margin-left:0pt;;text-indent:0pt;;color:#000000;font-size:11pt;font-family:Times New Roman;font-weight:normal;font-style:normal;text-transform:none;font-variant: normal;"><font style="Background-color:#FFFFFF;">Director</font></p></td>
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<p style="margin-top:24pt;margin-bottom:0pt;margin-left:19.15pt;;text-indent:0pt;;color:#000000;font-size:11pt;font-family:Times New Roman;font-weight:normal;font-style:normal;text-transform:none;font-variant: normal;"><font style="Background-color:#FFFFFF;">March 16, </font><font style="color:#000000;">2020</font></p></td>
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<p style="margin-top:24pt;margin-bottom:0pt;margin-left:0pt;;text-indent:0pt;;color:#000000;font-size:11pt;font-family:Times New Roman;font-weight:normal;font-style:normal;text-transform:none;font-variant: normal;"><font style="Background-color:#FFFFFF;text-decoration:underline;">/s/ David G. Kelly</font><font style="Background-color:#FFFFFF;"><br />David G. Kelly</font></p></td>
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<p style="margin-top:24pt;margin-bottom:0pt;margin-left:0pt;;text-indent:0pt;;color:#000000;font-size:11pt;font-family:Times New Roman;font-weight:normal;font-style:normal;text-transform:none;font-variant: normal;"><font style="Background-color:#FFFFFF;">Director</font></p></td>
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<p style="margin-top:24pt;margin-bottom:0pt;margin-left:19.15pt;;text-indent:0pt;;color:#000000;font-size:11pt;font-family:Times New Roman;font-weight:normal;font-style:normal;text-transform:none;font-variant: normal;"><font style="Background-color:#FFFFFF;">March 16, </font><font style="color:#000000;">2020</font></p></td>
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<p style="margin-top:24pt;margin-bottom:0pt;margin-left:0pt;;text-indent:0pt;;color:#000000;font-size:11pt;font-family:Times New Roman;font-weight:normal;font-style:normal;text-transform:none;font-variant: normal;"><font style="Background-color:#FFFFFF;">Director</font></p></td>
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<p style="margin-top:24pt;margin-bottom:0pt;margin-left:19.15pt;;text-indent:0pt;;color:#000000;font-size:11pt;font-family:Times New Roman;font-weight:normal;font-style:normal;text-transform:none;font-variant: normal;"><font style="Background-color:#FFFFFF;">March 16, </font><font style="color:#000000;">2020</font></p></td>
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itrm-s8.htm
As filed with the Securities and Exchange Commission on March 16, 2020
Registration No. 333-
UNITED STATES
SECURITIES AND EXCHANGE COMMISSION
Washington, D.C.  20549
FORM S-8
REGISTRATION STATEMENT
UNDER
THE SECURITIES ACT OF 1933
Iterum Therapeutics plc
(Exact Name of Registrant as Specified in Its Charter)
Ireland
98-1283148
(State or Other Jurisdiction of Incorporation or Organization)
(I.R.S. Employer Identification No.)
Block 2 Floor 3, Harcourt Centre,
Harcourt Street,
Dublin 2,
Ireland
(Address of Principal Executive Offices)
Not applicable
(Zip Code)
Iterum Therapeutics plc 2018 Equity Incentive Plan
(Full Title of the Plan)
Corey Fishman
President and Chief Executive Officer
200 South Wacker Dr., Suite 650
Chicago, IL 60606
(Name
and Address of Agent For Service)
(312) 778-6070
(Telephone Number, Including Area Code, of Agent For Service)
Copies to:
Brian A. Johnson, Esq.
Wilmer Cutler Pickering Hale and Dorr LLP
7 World Trade Center
250 Greenwich Street
New York, New York 10007
Telephone: (212) 230-8800
Fax: (212) 230-8888
Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, a smaller reporting company or an emerging growth company. See the definitions of "lar
ge accelerated filer," "accelerated filer," "smaller reporting company," and "emerging growth company" in Rule 12b-2 of the Exchange Act.
Large accelerated filer
☐
Accelerated filer
☐
Non-accelerated filer
☒
Smaller reporting company
☒
Emerging growth company
☒
If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 7(a)(2)(B) of the Securities Act.
☒
CALCULATION OF REGISTRATION FEE
Title of Securities to be Registered
Amount to be Registered(1)
Proposed Maximum Offering Price Per Share
Proposed Maximum Aggregate Offering Price
Amount of Registration Fee
Ordinary Shares, par value $0.01 per share
594,758 shares(2)
$1.87(3)
$1,112,198(3)
$144.37
(1)
Pursuant to Rule 416(a) promulgated under the Securities Act of 1933, as amended (the "Securities Act"), this Registration Statement shall also cover any additional ordinary shares of the Registrant ("Ordinary Shares") that become issuable under the Registrant's 2018 Equity Incentive Plan by reason of any stock dividend, stock split, recapitalization, or other similar transaction effected that results in an increase to the number of the Registrant's outstanding Ordinary Shares.
(2)
Represents additional Ordinary Shares reserved for future issuance under the Registrant's 2018 Equity Incentive Plan as a result of an annual increase.
(3)
Estimated solely for the purpose of calculating the registration fee pursuant to Rules 457(c) and 457(h) of the Securities Act. The price per share and aggregate offering price are calculated on the basis of $1.87, the average of the high and low sale prices of the Ordinary Shares as reported on the Nasdaq Global Market on March 13
, 2020
, in accordance with Rule 457(c) under the Securities Act.
EXPLANATORY NOTE
This Registration Statement on Form S-8, relating to the 2018 Equity Incentive Plan of Iterum Therapeutics plc (the "Registrant"), is being filed for the purpose of registering additional securities of the same class as other securities for which a Registration Statement on Form S-8 has previously been filed and is effective.  Accordi
ngly, this Registration Statement hereby incorporates by reference the contents of the following
Registration Statements
on Form S-8 previously
filed with the Securities and Exchange Commission (the "Commission") by the Registrant, except in each case for
Item 8.
Exhibits, with respect to which the Exhibit Index included in Part II of this Registration Statement
is incorporated herein by reference:
•
Registration St
atement on Form S-8
, File No. 333-225236,
filed with the Commission on May 25, 2018 by the Registrant,
relating to the Registrant's 2015 Equity Incentive Plan
and 2018 Equity Incentive Plan.
•
Registration Statement on Form S-8, File No. 333-230496, filed with the Commission on March 25, 2019 by the Registrant, relating to the Registrant's 2018 Equity Incentive Plan
.
PART II
INFORMATION REQUIRED IN THE REGISTRATION STATEMENT
ITEM 8.
EXHIBITS
Exhibit
Number
Description
4.1(1)
Constitution of the Registrant
5.1
Opinion of A&L Goodbody
23.1
Consent of A&L Goodbody (included in Exhibit 5.1)
23.2
Consent of KPMG, Independent Registered Public Accounting Firm
24.1
Power of attorney (included on the signature pages of this registration statement)
99.1(2)
2018 Equity Incentive Plan
____________
(1)
Previously filed as Exhibit 3.1 to the Registrant's Current Report on Form 8-K (File No. 001-38503), filed with the Commission on May 30, 2018, and incorporated by reference herein.
(2)
Previously filed as Exhibit 10.6 to Amendment No. 2 to the Registrant's registration statement on Form S-1 (File No. 333-224582), filed with the Commission on May 16, 2018, and incorporated by reference herein.
SIGNATURES
Pursuant to the requirements of the Securities Act of 1933, the registrant certifies that it has reasonable grounds to believe that it meets all of the requirements for filing on Form S-8 and has duly caused this registration statement to be signed on its behalf by the un
dersigned, thereunto duly authorized, in the City of Chicago, State of Illinois, on this 16
th
day of March, 2020.
ITERUM THERAPEUTICS PLC
By:
/s/Corey N. Fishman
Corey N. Fishman
President and Chief Executive Officer
POWER OF ATTORNEY AND SIGNATURES
We, the undersigned officers and directors of Iterum Therapeutics plc, hereby severally constitute and appoint Corey N. Fishman and Judith M. Matthews, and each of them singly, our true and lawful attorneys with full power to them, and each of them singly, to sign for us and in our names in the capacities indicated below, the registration statement on Form S-8 filed herewith and any and all subsequent amendments to said registration statement, and generally to do all such things in our names and on our behalf in our capacities as officers and directors to enable Iterum Therapeutics plc to comply with the provisions of the Securities Act of 1933,  and all requirements of the Securities and Exchange Commission, hereby ratifying and confirming our signatures as they may be signed by our said attorneys, or any of them, to said registration statement and any and all amendments thereto.
Pursuant to the requirements of the Securities Act of 1933, this registration statement has been signed by the following persons in the capacities and on the dates indicated.
Signature
Title
Date
/s/Corey N. Fishman
Corey N. Fishman
President, Chief Executive Officer and Director (Principal Executive Officer)
March 16,
2020
/s/Judith M. Matthews
Judith M. Matthews
Chief Financial Officer
(Principal Financial and Accounting Officer)
March 16,
2020
/s/ Brenton K. Ahrens
Brenton K. Ahrens
Director
March 16,
2020
/s/ Mark Chin
Mark Chin
Director
March 16,
2020
/s/ Patrick J. Heron
Patrick J. Heron
Director
March 16,
2020
/s/ Ronald M. Hunt
Ronald M. Hunt
Director
March 16,
2020
/s/ David G. Kelly
David G. Kelly
Director
March 16,
2020
/s/ Shahzad Malik
Shahzad Malik, M.D.
Director
March 16,
2020