id stringlengths 1 3 | document_id stringlengths 9 13 | passages list | entities list | events list | coreferences list | relations list |
|---|---|---|---|---|---|---|
0 | PMID-10190553 | [
{
"id": "PMID-10190553__text",
"type": "abstract",
"text": [
"Regulation of connexin32 and connexin43 gene expression by DNA methylation in rat liver cells. \nGap junction proteins (connexins) are expressed in a cell-specific manner and expression is often reduced in neoplastic cells. We investiga... | [
{
"id": "PMID-10190553_T1",
"type": "Protein",
"text": [
"connexin32"
],
"offsets": [
[
14,
24
]
],
"normalized": []
},
{
"id": "PMID-10190553_T2",
"type": "Protein",
"text": [
"connexin43"
],
"offsets": [
[
29... | [
{
"id": "PMID-10190553_E1",
"type": "DNA_methylation",
"trigger": {
"text": [
"methylated"
],
"offsets": [
[
662,
672
]
]
},
"arguments": [
{
"role": "Theme",
"ref_id": "PMID-10190553_T15"
},
{
... | [
{
"id": "PMID-10190553_1",
"entity_ids": [
"PMID-10190553_T3",
"PMID-10190553_T4"
]
},
{
"id": "PMID-10190553_2",
"entity_ids": [
"PMID-10190553_T5",
"PMID-10190553_T6"
]
}
] | [] |
1 | PMID-10196193 | [
{
"id": "PMID-10196193__text",
"type": "abstract",
"text": [
"CheY-dependent methylation of the asparagine receptor, McpB, during chemotaxis in Bacillus subtilis. \nFor the Gram-positive organism Bacillus subtilis, chemotaxis to the attractant asparagine is mediated by the chemoreceptor McpB. In t... | [
{
"id": "PMID-10196193_T1",
"type": "Protein",
"text": [
"CheY"
],
"offsets": [
[
0,
4
]
],
"normalized": []
},
{
"id": "PMID-10196193_T2",
"type": "Protein",
"text": [
"McpB"
],
"offsets": [
[
55,
59
... | [
{
"id": "PMID-10196193_E1",
"type": "Methylation",
"trigger": {
"text": [
"methylation"
],
"offsets": [
[
15,
26
]
]
},
"arguments": [
{
"role": "Theme",
"ref_id": "PMID-10196193_T2"
}
]
},
{
... | [] | [] |
2 | PMID-10209866 | [
{
"id": "PMID-10209866__text",
"type": "abstract",
"text": [
"Transglycosylation reactions of Bacillus stearothermophilus maltogenic amylase with acarbose and various acceptors. \nIt was observed that Bacillus stearothermophilus maltogenic amylase cleaved the first glycosidic bond of acarbose to p... | [
{
"id": "PMID-10209866_T1",
"type": "Protein",
"text": [
"maltogenic amylase"
],
"offsets": [
[
60,
78
]
],
"normalized": []
},
{
"id": "PMID-10209866_T2",
"type": "Protein",
"text": [
"maltogenic amylase"
],
"offsets": [
... | [] | [] | [] |
3 | PMID-10219568 | [
{
"id": "PMID-10219568__text",
"type": "abstract",
"text": [
"A Plasmodium chabaudi chabaudi high molecular mass glycoprotein translocated to the host cell membrane by a non-classical secretory pathway. \nWe have purified and characterized a novel high molecular mass glycoprotein of P. chabaudi ch... | [
{
"id": "PMID-10219568_T1",
"type": "Protein",
"text": [
"Pc550gp"
],
"offsets": [
[
243,
250
]
],
"normalized": []
},
{
"id": "PMID-10219568_T2",
"type": "Protein",
"text": [
"Pc550gp"
],
"offsets": [
[
411,
... | [] | [] | [] |
4 | PMID-10360176 | [
{
"id": "PMID-10360176__text",
"type": "abstract",
"text": [
"Novel roles for classical factors at the interface between translation termination and initiation. \nThe pathway of bacterial ribosome recycling following translation termination has remained obscure. Here, we elucidate two essential st... | [
{
"id": "PMID-10360176_T1",
"type": "Protein",
"text": [
"EF-G"
],
"offsets": [
[
302,
306
]
],
"normalized": []
},
{
"id": "PMID-10360176_T2",
"type": "Protein",
"text": [
"RRF"
],
"offsets": [
[
308,
... | [] | [] | [] |
5 | PMID-10428866 | [
{
"id": "PMID-10428866__text",
"type": "abstract",
"text": [
"Effect of alternative glycosylation on insulin receptor processing. \nThe mature insulin receptor is a cell surface heterotetrameric glycoprotein composed of two alpha- and two beta-subunits. In 3T3-L1 adipocytes as in other cell types,... | [
{
"id": "PMID-10428866_T1",
"type": "Protein",
"text": [
"insulin receptor"
],
"offsets": [
[
39,
55
]
],
"normalized": []
},
{
"id": "PMID-10428866_T2",
"type": "Protein",
"text": [
"insulin receptor"
],
"offsets": [
... | [
{
"id": "PMID-10428866_E1",
"type": "Glycosylation",
"trigger": {
"text": [
"glycosylation"
],
"offsets": [
[
22,
35
]
]
},
"arguments": [
{
"role": "Theme",
"ref_id": "PMID-10428866_T1"
}
]
},
... | [] | [] |
6 | PMID-10443949 | [
{
"id": "PMID-10443949__text",
"type": "abstract",
"text": [
"Meat, metabolic genotypes and risk for colorectal cancer. \nPersuasive data exist as to the importance of environmental factors in the pathogenesis of sporadic colorectal cancer. One possibility is that the effect of environmental facto... | [
{
"id": "PMID-10443949_T1",
"type": "Protein",
"text": [
"NAT1"
],
"offsets": [
[
455,
459
]
],
"normalized": []
},
{
"id": "PMID-10443949_T2",
"type": "Protein",
"text": [
"NAT2"
],
"offsets": [
[
461,
... | [] | [
{
"id": "PMID-10443949_1",
"entity_ids": [
"PMID-10443949_T7",
"PMID-10443949_T8"
]
}
] | [] |
7 | PMID-10457259 | [
{
"id": "PMID-10457259__text",
"type": "abstract",
"text": [
"Differential expression of human lysyl hydroxylase genes, lysine hydroxylation, and cross-linking of type I collagen during osteoblastic differentiation in vitro. \nThe pattern of lysyl hydroxylation in the nontriple helical domains of ... | [
{
"id": "PMID-10457259_T1",
"type": "Protein",
"text": [
"Procollagen-lysine,2-oxyglutarate,5-dioxygenase 1"
],
"offsets": [
[
477,
526
]
],
"normalized": []
},
{
"id": "PMID-10457259_T2",
"type": "Protein",
"text": [
"2"
],
... | [] | [
{
"id": "PMID-10457259_1",
"entity_ids": [
"PMID-10457259_T1",
"PMID-10457259_T4"
]
},
{
"id": "PMID-10457259_2",
"entity_ids": [
"PMID-10457259_T2",
"PMID-10457259_T5"
]
},
{
"id": "PMID-10457259_3",
"entity_ids": [
"PMID-10457259_T3",
"PM... | [] |
8 | PMID-10460145 | [
{
"id": "PMID-10460145__text",
"type": "abstract",
"text": [
"Phenylalanine residues in the active site of tyrosine hydroxylase: mutagenesis of Phe300 and Phe309 to alanine and metal ion-catalyzed hydroxylation of Phe300. \nResidues Phe300 and Phe309 of tyrosine hydroxylase are located in the acti... | [
{
"id": "PMID-10460145_T1",
"type": "Protein",
"text": [
"tyrosine hydroxylase"
],
"offsets": [
[
45,
65
]
],
"normalized": []
},
{
"id": "PMID-10460145_T2",
"type": "Protein",
"text": [
"tyrosine hydroxylase"
],
"offsets": ... | [] | [] | [] |
9 | PMID-10463816 | [
{
"id": "PMID-10463816__text",
"type": "abstract",
"text": [
"Development of an enzyme-linked immunosorbent assay, using a monoclonal antibody against alpha2-macroglobulin, for the diagnosis of systemic lupus erythematosus. \nOBJECTIVES: To develop an enzyme-linked immunosorbent assay (ELISA) usin... | [
{
"id": "PMID-10463816_T1",
"type": "Protein",
"text": [
"alpha2-macroglobulin"
],
"offsets": [
[
89,
109
]
],
"normalized": []
},
{
"id": "PMID-10463816_T2",
"type": "Protein",
"text": [
"alpha2-macroglobulin"
],
"offsets":... | [
{
"id": "PMID-10463816_E1",
"type": "Glycosylation",
"trigger": {
"text": [
"glycosylated"
],
"offsets": [
[
293,
305
]
]
},
"arguments": [
{
"role": "Theme",
"ref_id": "PMID-10463816_T2"
}
]
},... | [
{
"id": "PMID-10463816_1",
"entity_ids": [
"PMID-10463816_T2",
"PMID-10463816_T3"
]
}
] | [] |
10 | PMID-10485883 | [
{
"id": "PMID-10485883__text",
"type": "abstract",
"text": [
"Efficient adaptational demethylation of chemoreceptors requires the same enzyme-docking site as efficient methylation. \nThe mechanistic basis of sensory adaptation and gradient sensing in bacterial chemotaxis is reversible covalent mod... | [
{
"id": "PMID-10485883_T1",
"type": "Protein",
"text": [
"CheR"
],
"offsets": [
[
432,
436
]
],
"normalized": []
},
{
"id": "PMID-10485883_T2",
"type": "Protein",
"text": [
"CheB"
],
"offsets": [
[
468,
... | [] | [] | [] |
11 | PMID-10490608 | [
{
"id": "PMID-10490608__text",
"type": "abstract",
"text": [
"Roles of cell division and gene transcription in the methylation of CpG islands. \nDe novo methylation of CpG islands within the promoters of eukaryotic genes is often associated with their transcriptional repression, yet the methylatio... | [
{
"id": "PMID-10490608_T1",
"type": "Protein",
"text": [
"p16"
],
"offsets": [
[
402,
405
]
],
"normalized": []
},
{
"id": "PMID-10490608_T2",
"type": "Protein",
"text": [
"p16"
],
"offsets": [
[
728,
7... | [
{
"id": "PMID-10490608_E1",
"type": "DNA_demethylation",
"trigger": {
"text": [
"demethylation"
],
"offsets": [
[
362,
375
]
]
},
"arguments": [
{
"role": "Theme",
"ref_id": "PMID-10490608_T1"
},
... | [] | [] |
12 | PMID-10495421 | [
{
"id": "PMID-10495421__text",
"type": "abstract",
"text": [
"Distinct methylation pattern and microsatellite instability in sporadic gastric cancer. \nAberrant 5' CpG island methylation is an alternative mechanism of gene inactivation during the development of cancer as demonstrated for several t... | [
{
"id": "PMID-10495421_T1",
"type": "Protein",
"text": [
"MLH1"
],
"offsets": [
[
438,
442
]
],
"normalized": []
},
{
"id": "PMID-10495421_T2",
"type": "Protein",
"text": [
"MLH1"
],
"offsets": [
[
565,
... | [
{
"id": "PMID-10495421_E1",
"type": "DNA_methylation",
"trigger": {
"text": [
"hypermethylation"
],
"offsets": [
[
470,
486
]
]
},
"arguments": [
{
"role": "Theme",
"ref_id": "PMID-10495421_T1"
},
... | [] | [] |
13 | PMID-10532353 | [
{
"id": "PMID-10532353__text",
"type": "abstract",
"text": [
"Effect of HSP47 on prolyl 4-hydroxylation of collagen model peptides. \nProlyl 4-hydroxylation, the most important post-translational modification in collagen biosynthesis, is catalyzed by prolyl 4-hydroxylase, an endoplasmic reticulum-... | [
{
"id": "PMID-10532353_T1",
"type": "Protein",
"text": [
"HSP47"
],
"offsets": [
[
10,
15
]
],
"normalized": []
},
{
"id": "PMID-10532353_T2",
"type": "Protein",
"text": [
"HSP47"
],
"offsets": [
[
252,
... | [] | [] | [] |
14 | PMID-10564083 | [
{
"id": "PMID-10564083__text",
"type": "abstract",
"text": [
"Mouse K-Cl cotransporter KCC1: cloning, mapping, pathological expression, and functional regulation. \nAlthough K-Cl cotransporter (KCC1) mRNA is expressed in many tissues, K-Cl cotransport activity has been measured in few cell types, ... | [
{
"id": "PMID-10564083_T1",
"type": "Protein",
"text": [
"KCC1"
],
"offsets": [
[
25,
29
]
],
"normalized": []
},
{
"id": "PMID-10564083_T2",
"type": "Protein",
"text": [
"KCC1"
],
"offsets": [
[
131,
1... | [] | [] | [] |
15 | PMID-10566667 | [
{
"id": "PMID-10566667__text",
"type": "abstract",
"text": [
"Progesterone metabolism in the human kidney and inhibition of 11beta-hydroxysteroid dehydrogenase type 2 by progesterone and its metabolites. \nProgesterone binds with high affinity to the mineralocorticoid (MC) receptor, but confers on... | [
{
"id": "PMID-10566667_T1",
"type": "Protein",
"text": [
"11beta-hydroxysteroid dehydrogenase type 2"
],
"offsets": [
[
62,
104
]
],
"normalized": []
},
{
"id": "PMID-10566667_T2",
"type": "Protein",
"text": [
"mineralocorticoid (MC... | [] | [] | [] |
16 | PMID-10593387 | [
{
"id": "PMID-10593387__text",
"type": "abstract",
"text": [
"Deglycosylation of a bifunctional lutropin-follitropin agonist reduced its follitropin activity more than its lutropin activity. \nOBJECTIVE: To design a drug that blocks the gonadal actions of lutropins and follitropins. DESIGN: Contro... | [
{
"id": "PMID-10593387_T1",
"type": "Protein",
"text": [
"LH"
],
"offsets": [
[
417,
419
]
],
"normalized": []
},
{
"id": "PMID-10593387_T2",
"type": "Protein",
"text": [
"FSH receptors"
],
"offsets": [
[
424,
... | [] | [] | [] |
17 | PMID-10601977 | [
{
"id": "PMID-10601977__text",
"type": "abstract",
"text": [
"Regulation of thyrotropin receptor protein expression in insect cells. \nExpression of large quantities of conformationally intact thyrotropin receptor (TSHR) is essential to understand the structure-function relationship of the recepto... | [
{
"id": "PMID-10601977_T1",
"type": "Protein",
"text": [
"thyrotropin receptor"
],
"offsets": [
[
14,
34
]
],
"normalized": []
},
{
"id": "PMID-10601977_T2",
"type": "Protein",
"text": [
"thyrotropin receptor"
],
"offsets": ... | [
{
"id": "PMID-10601977_E1",
"type": "Glycosylation",
"trigger": {
"text": [
"glycosylated"
],
"offsets": [
[
1007,
1019
]
]
},
"arguments": [
{
"role": "Theme",
"ref_id": "PMID-10601977_T17"
}
]
... | [
{
"id": "PMID-10601977_1",
"entity_ids": [
"PMID-10601977_T2",
"PMID-10601977_T3"
]
}
] | [] |
18 | PMID-10672186 | [
{
"id": "PMID-10672186__text",
"type": "abstract",
"text": [
"BasT, a membrane-bound transducer protein for amino acid detection in Halobacterium salinarum. \nHalophilic archaea, such as eubacteria, use methyl-accepting chemotaxis proteins (MCPs) to sense their environment. We show here that BasT ... | [
{
"id": "PMID-10672186_T1",
"type": "Protein",
"text": [
"BasT"
],
"offsets": [
[
0,
4
]
],
"normalized": []
},
{
"id": "PMID-10672186_T2",
"type": "Protein",
"text": [
"BasT"
],
"offsets": [
[
230,
234... | [
{
"id": "PMID-10672186_E1",
"type": "Methylation",
"trigger": {
"text": [
"methylatable"
],
"offsets": [
[
962,
974
]
]
},
"arguments": [
{
"role": "Theme",
"ref_id": "PMID-10672186_T5"
}
]
}
] | [] | [] |
19 | PMID-10715549 | [
{
"id": "PMID-10715549__text",
"type": "abstract",
"text": [
"Additional N-glycosylation at Asn(13) rescues the human LHbeta-subunit from disulfide-linked aggregation. \nCG, LH, FSH, and TSH are a family of heterodimeric glycoprotein hormones that contain a common alpha-subunit, but differ in thei... | [
{
"id": "PMID-10715549_T1",
"type": "Protein",
"text": [
"LHbeta"
],
"offsets": [
[
56,
62
]
],
"normalized": []
},
{
"id": "PMID-10715549_T2",
"type": "Protein",
"text": [
"LHbeta"
],
"offsets": [
[
311,
... | [
{
"id": "PMID-10715549_E1",
"type": "Glycosylation",
"trigger": {
"text": [
"N-glycosylation"
],
"offsets": [
[
11,
26
]
]
},
"arguments": [
{
"role": "Theme",
"ref_id": "PMID-10715549_T1"
},
{
... | [] | [] |
20 | PMID-10722741 | [
{
"id": "PMID-10722741__text",
"type": "abstract",
"text": [
"Type XIII collagen forms homotrimers with three triple helical collagenous domains and its association into disulfide-bonded trimers is enhanced by prolyl 4-hydroxylase. \nType XIII collagen is a type II transmembrane protein predicted ... | [
{
"id": "PMID-10722741_T1",
"type": "Protein",
"text": [
"Type XIII collagen"
],
"offsets": [
[
0,
18
]
],
"normalized": []
},
{
"id": "PMID-10722741_T2",
"type": "Protein",
"text": [
"Type XIII collagen"
],
"offsets": [
... | [
{
"id": "PMID-10722741_E1",
"type": "Hydroxylation",
"trigger": {
"text": [
"hydroxylation"
],
"offsets": [
[
843,
856
]
]
},
"arguments": [
{
"role": "Theme",
"ref_id": "PMID-10722741_T4"
},
{
... | [] | [] |
21 | PMID-10729220 | [
{
"id": "PMID-10729220__text",
"type": "abstract",
"text": [
"Symmetric and asymmetric DNA methylation in the human IGF2-H19 imprinted region. \nThe two contiguous IGF2 (human insulin-like growth factor II) and H19 genes are reciprocally imprinted in both human and mouse. In most tissues, IGF2 is ... | [
{
"id": "PMID-10729220_T1",
"type": "Protein",
"text": [
"IGF2"
],
"offsets": [
[
54,
58
]
],
"normalized": []
},
{
"id": "PMID-10729220_T2",
"type": "Protein",
"text": [
"H19"
],
"offsets": [
[
59,
62
... | [
{
"id": "PMID-10729220_E1",
"type": "DNA_methylation",
"trigger": {
"text": [
"DNA methylation"
],
"offsets": [
[
25,
40
]
]
},
"arguments": [
{
"role": "Theme",
"ref_id": "PMID-10729220_T1"
},
... | [
{
"id": "PMID-10729220_1",
"entity_ids": [
"PMID-10729220_T3",
"PMID-10729220_T4"
]
}
] | [] |
22 | PMID-10746157 | [
{
"id": "PMID-10746157__text",
"type": "abstract",
"text": [
"An increase in histone acetylation and IL-2 antagonizing the immunoinhibitory effect are necessary for augmentation by butyrate of in vitro anti-TNP antibody production. \nWe investigated the role of histone acetylation in the promotion... | [
{
"id": "PMID-10746157_T1",
"type": "Protein",
"text": [
"histone"
],
"offsets": [
[
15,
22
]
],
"normalized": []
},
{
"id": "PMID-10746157_T2",
"type": "Protein",
"text": [
"IL-2"
],
"offsets": [
[
39,
... | [
{
"id": "PMID-10746157_E1",
"type": "Acetylation",
"trigger": {
"text": [
"acetylation"
],
"offsets": [
[
23,
34
]
]
},
"arguments": [
{
"role": "Theme",
"ref_id": "PMID-10746157_T1"
}
]
},
{
... | [
{
"id": "PMID-10746157_1",
"entity_ids": [
"PMID-10746157_T4",
"PMID-10746157_T5"
]
}
] | [] |
23 | PMID-10799457 | [
{
"id": "PMID-10799457__text",
"type": "abstract",
"text": [
"New immunofluorescence assays for detection of Human herpesvirus 8-specific antibodies. \nSeveral assays have been developed for detection of immunoglobulin G antibodies to Human herpesvirus 8 (HHV-8), including immunofluorescence assay... | [
{
"id": "PMID-10799457_T1",
"type": "Protein",
"text": [
"ORF73"
],
"offsets": [
[
783,
788
]
],
"normalized": []
},
{
"id": "PMID-10799457_T2",
"type": "Protein",
"text": [
"K8.1"
],
"offsets": [
[
793,
... | [] | [] | [] |
24 | PMID-10880980 | [
{
"id": "PMID-10880980__text",
"type": "abstract",
"text": [
"Evidence that the lizard helospectin peptides are O-glycosylated. \nSix forms of helospectin (a vasoactive intestinal peptide analogue) were purified from the venom of the Heloderma horridum lizard. Their identification was performed by... | [
{
"id": "PMID-10880980_T1",
"type": "Protein",
"text": [
"helospectin"
],
"offsets": [
[
25,
36
]
],
"normalized": []
},
{
"id": "PMID-10880980_T2",
"type": "Protein",
"text": [
"helospectin"
],
"offsets": [
[
... | [
{
"id": "PMID-10880980_E1",
"type": "Glycosylation",
"trigger": {
"text": [
"O-glycosylated"
],
"offsets": [
[
50,
64
]
]
},
"arguments": [
{
"role": "Theme",
"ref_id": "PMID-10880980_T1"
}
]
},... | [] | [] |
25 | PMID-10898761 | [
{
"id": "PMID-10898761__text",
"type": "abstract",
"text": [
"Changes in methionine adenosyltransferase and S-adenosylmethionine homeostasis in alcoholic rat liver. \nLiver-specific and non-liver-specific methionine adenosyltransferase (MAT) are products of two genes, MAT1A and MAT2A, respectively... | [
{
"id": "PMID-10898761_T1",
"type": "Protein",
"text": [
"MAT1A"
],
"offsets": [
[
206,
211
]
],
"normalized": []
},
{
"id": "PMID-10898761_T2",
"type": "Protein",
"text": [
"MAT2A"
],
"offsets": [
[
216,
... | [
{
"id": "PMID-10898761_E1",
"type": "DNA_methylation",
"trigger": {
"text": [
"hypomethylated"
],
"offsets": [
[
920,
934
]
]
},
"arguments": [
{
"role": "Theme",
"ref_id": "PMID-10898761_T5"
}
]
... | [] | [] |
26 | PMID-10903903 | [
{
"id": "PMID-10903903__text",
"type": "abstract",
"text": [
"Hsl7p, the yeast homologue of human JBP1, is a protein methyltransferase. \nThe yeast protein Hsl7p is a homologue of Janus kinase binding protein 1, JBP1, a newly characterized protein methyltransferase. In this report, Hsl7p also is s... | [
{
"id": "PMID-10903903_T1",
"type": "Protein",
"text": [
"Hsl7p"
],
"offsets": [
[
0,
5
]
],
"normalized": []
},
{
"id": "PMID-10903903_T2",
"type": "Protein",
"text": [
"JBP1"
],
"offsets": [
[
36,
40
... | [
{
"id": "PMID-10903903_E1",
"type": "Methylation",
"trigger": {
"text": [
"methylated"
],
"offsets": [
[
433,
443
]
]
},
"arguments": [
{
"role": "Theme",
"ref_id": "PMID-10903903_T7"
}
]
},
{... | [
{
"id": "PMID-10903903_1",
"entity_ids": [
"PMID-10903903_T4",
"PMID-10903903_T5"
]
}
] | [] |
27 | PMID-10938272 | [
{
"id": "PMID-10938272__text",
"type": "abstract",
"text": [
"Rapid induction of histone hyperacetylation and cellular differentiation in human breast tumor cell lines following degradation of histone deacetylase-1. \nQuinidine inhibits proliferation and promotes cellular differentiation in human ... | [
{
"id": "PMID-10938272_T1",
"type": "Protein",
"text": [
"histone"
],
"offsets": [
[
19,
26
]
],
"normalized": []
},
{
"id": "PMID-10938272_T2",
"type": "Protein",
"text": [
"histone deacetylase-1"
],
"offsets": [
[
... | [
{
"id": "PMID-10938272_E1",
"type": "Acetylation",
"trigger": {
"text": [
"hyperacetylation"
],
"offsets": [
[
27,
43
]
]
},
"arguments": [
{
"role": "Theme",
"ref_id": "PMID-10938272_T1"
}
]
},... | [
{
"id": "PMID-10938272_1",
"entity_ids": [
"PMID-10938272_T5",
"PMID-10938272_T6"
]
}
] | [] |
28 | PMID-10960154 | [
{
"id": "PMID-10960154__text",
"type": "abstract",
"text": [
"Glycosylation influences gating and pH sensitivity of I(sK). \nThe KvLQT1 and minK subunits that coassemble to form I(sK) channels, contain potential N-glycosylation sites. To examine the role of glycosylation in channel function, a Chi... | [
{
"id": "PMID-10960154_T1",
"type": "Protein",
"text": [
"KvLQT1"
],
"offsets": [
[
66,
72
]
],
"normalized": []
},
{
"id": "PMID-10960154_T2",
"type": "Protein",
"text": [
"minK"
],
"offsets": [
[
77,
... | [
{
"id": "PMID-10960154_E1",
"type": "Glycosylation",
"trigger": {
"text": [
"attached"
],
"offsets": [
[
1398,
1406
]
]
},
"arguments": [
{
"role": "Theme",
"ref_id": "PMID-10960154_T18"
},
{
... | [] | [] |
29 | PMID-10973948 | [
{
"id": "PMID-10973948__text",
"type": "abstract",
"text": [
"A novel post-translational modification of yeast elongation factor 1A. Methylesterification at the C terminus. \nProtein methylation reactions can play important roles in cell physiology. After labeling intact Saccharomyces cerevisiae ... | [
{
"id": "PMID-10973948_T1",
"type": "Protein",
"text": [
"elongation factor 1A"
],
"offsets": [
[
49,
69
]
],
"normalized": []
},
{
"id": "PMID-10973948_T2",
"type": "Protein",
"text": [
"elongation factor 1A"
],
"offsets": ... | [
{
"id": "PMID-10973948_E1",
"type": "Methylation",
"trigger": {
"text": [
"Methylesterification"
],
"offsets": [
[
72,
92
]
]
},
"arguments": [
{
"role": "Theme",
"ref_id": "PMID-10973948_T1"
},
... | [
{
"id": "PMID-10973948_1",
"entity_ids": [
"PMID-10973948_T2",
"PMID-10973948_T3",
"PMID-10973948_T4"
]
}
] | [] |
30 | PMID-11013212 | [
{
"id": "PMID-11013212__text",
"type": "abstract",
"text": [
"Decreased UDP-GlcNAc levels abrogate proliferation control in EMeg32-deficient cells. \nThe hexosamine pathway provides UDP-N:-acetylhexosamine donor substrates used in cytosolic and Golgi-mediated glycosylation of proteins and for form... | [
{
"id": "PMID-11013212_T1",
"type": "Protein",
"text": [
"EMeg32"
],
"offsets": [
[
62,
68
]
],
"normalized": []
},
{
"id": "PMID-11013212_T2",
"type": "Protein",
"text": [
"glucosamine-6-phosphate (GlcN6P) acetyltransferase"
],... | [] | [
{
"id": "PMID-11013212_1",
"entity_ids": [
"PMID-11013212_T2",
"PMID-11013212_T3"
]
},
{
"id": "PMID-11013212_2",
"entity_ids": [
"PMID-11013212_T9",
"PMID-11013212_T10"
]
}
] | [] |
31 | PMID-11032800 | [
{
"id": "PMID-11032800__text",
"type": "abstract",
"text": [
"Post-translational hydroxylation at the N-terminus of the prion protein reveals presence of PPII structure in vivo. \nThe transmissible spongiform encephalopathies are characterized by conversion of a host protein, PrP(C) (cellular prio... | [
{
"id": "PMID-11032800_T1",
"type": "Protein",
"text": [
"prion protein"
],
"offsets": [
[
58,
71
]
],
"normalized": []
},
{
"id": "PMID-11032800_T2",
"type": "Protein",
"text": [
"PrP(C)"
],
"offsets": [
[
214... | [
{
"id": "PMID-11032800_E1",
"type": "Hydroxylation",
"trigger": {
"text": [
"hydroxylation"
],
"offsets": [
[
19,
32
]
]
},
"arguments": [
{
"role": "Theme",
"ref_id": "PMID-11032800_T1"
},
{
... | [
{
"id": "PMID-11032800_1",
"entity_ids": [
"PMID-11032800_T2",
"PMID-11032800_T3"
]
},
{
"id": "PMID-11032800_2",
"entity_ids": [
"PMID-11032800_T4",
"PMID-11032800_T5"
]
}
] | [] |
32 | PMID-11038366 | [
{
"id": "PMID-11038366__text",
"type": "abstract",
"text": [
"Carboxymethylation of the PP2A catalytic subunit in Saccharomyces cerevisiae is required for efficient interaction with the B-type subunits Cdc55p and Rts1p. \nProtein phosphatase 2A (PP2A) is an essential eukaryotic serine/threonine ph... | [
{
"id": "PMID-11038366_T1",
"type": "Protein",
"text": [
"Cdc55p"
],
"offsets": [
[
140,
146
]
],
"normalized": []
},
{
"id": "PMID-11038366_T2",
"type": "Protein",
"text": [
"Rts1p"
],
"offsets": [
[
151,
... | [
{
"id": "PMID-11038366_E1",
"type": "Methylation",
"trigger": {
"text": [
"methylation"
],
"offsets": [
[
1818,
1829
]
]
},
"arguments": [
{
"role": "Theme",
"ref_id": "PMID-11038366_T19"
}
]
}
... | [] | [] |
33 | PMID-11055323 | [
{
"id": "PMID-11055323__text",
"type": "abstract",
"text": [
"Safety and pharmacokinetic study with escalating doses of 3-acetyl-7-oxo-dehydroepiandrosterone in healthy male volunteers. \nOBJECTIVES: To evaluate the safety and pharmacokinetics of 3-acetyl-7-oxo-DHEA (3beta-acetoxyandrost-5-ene-7,1... | [
{
"id": "PMID-11055323_T1",
"type": "Protein",
"text": [
"insulin"
],
"offsets": [
[
825,
832
]
],
"normalized": []
}
] | [] | [] | [] |
34 | PMID-11073455 | [
{
"id": "PMID-11073455__text",
"type": "abstract",
"text": [
"Aureusidin synthase: a polyphenol oxidase homolog responsible for flower coloration. \nAurones are plant flavonoids that provide yellow color to the flowers of some popular ornamental plants, such as snapdragon and cosmos. In this study... | [
{
"id": "PMID-11073455_T1",
"type": "Protein",
"text": [
"Aureusidin synthase"
],
"offsets": [
[
0,
19
]
],
"normalized": []
},
{
"id": "PMID-11073455_T2",
"type": "Protein",
"text": [
"aureusidin synthase"
],
"offsets": [
... | [] | [] | [] |
35 | PMID-11106238 | [
{
"id": "PMID-11106238__text",
"type": "abstract",
"text": [
"E-cadherin expression is silenced by 5' CpG island methylation in acute leukemia. \nE-Cadherin is a transmembrane glycoprotein that mediates Ca2+-dependent intercellular adhesion in normal epithelium. In tumors of epithelial origin, E-c... | [
{
"id": "PMID-11106238_T1",
"type": "Protein",
"text": [
"E-cadherin"
],
"offsets": [
[
0,
10
]
],
"normalized": []
},
{
"id": "PMID-11106238_T2",
"type": "Protein",
"text": [
"E-Cadherin"
],
"offsets": [
[
83,... | [
{
"id": "PMID-11106238_E1",
"type": "DNA_methylation",
"trigger": {
"text": [
"methylation"
],
"offsets": [
[
51,
62
]
]
},
"arguments": [
{
"role": "Theme",
"ref_id": "PMID-11106238_T1"
},
{
... | [] | [] |
36 | PMID-11159919 | [
{
"id": "PMID-11159919__text",
"type": "abstract",
"text": [
"Defect in N-glycosylation of proteins is tissue-dependent in congenital disorders of glycosylation Ia. \nThe biochemical hallmark of Congenital Disorders of Glycosylation (CDG) including type Ia is a defective N-glycosylation of serum g... | [
{
"id": "PMID-11159919_T1",
"type": "Protein",
"text": [
"alpha1-antitrypsin"
],
"offsets": [
[
275,
293
]
],
"normalized": []
},
{
"id": "PMID-11159919_T2",
"type": "Protein",
"text": [
"alpha1-antitrypsin"
],
"offsets": [
... | [
{
"id": "PMID-11159919_E1",
"type": "Glycosylation",
"trigger": {
"text": [
"Hypoglycosylated"
],
"offsets": [
[
249,
265
]
]
},
"arguments": [
{
"role": "Theme",
"ref_id": "PMID-11159919_T1"
}
]
... | [] | [] |
37 | PMID-11162640 | [
{
"id": "PMID-11162640__text",
"type": "abstract",
"text": [
"Molecular cloning and characterization of CHM1L, a novel membrane molecule similar to chondromodulin-I. \nChondromodulin-I (ChM-I) is a cartilage-specific glycoprotein that stimulates the growth of chondrocytes and inhibits the tube for... | [
{
"id": "PMID-11162640_T1",
"type": "Protein",
"text": [
"CHM1L"
],
"offsets": [
[
42,
47
]
],
"normalized": []
},
{
"id": "PMID-11162640_T2",
"type": "Protein",
"text": [
"chondromodulin-I"
],
"offsets": [
[
8... | [
{
"id": "PMID-11162640_E1",
"type": "Glycosylation",
"trigger": {
"text": [
"N-glycosylated"
],
"offsets": [
[
539,
553
]
]
},
"arguments": [
{
"role": "Theme",
"ref_id": "PMID-11162640_T9"
}
]
... | [
{
"id": "PMID-11162640_1",
"entity_ids": [
"PMID-11162640_T3",
"PMID-11162640_T4"
]
}
] | [] |
38 | PMID-11281648 | [
{
"id": "PMID-11281648__text",
"type": "abstract",
"text": [
"Targeting of calsequestrin to the sarcoplasmic reticulum of skeletal muscle upon deletion of its glycosylation site. \nThe glycoprotein calsequestrin (CS) is segregated to the junctional sarcoplasmic reticulum (jSR) and is responsible f... | [
{
"id": "PMID-11281648_T1",
"type": "Protein",
"text": [
"hemoagglutinin 1"
],
"offsets": [
[
281,
297
]
],
"normalized": []
},
{
"id": "PMID-11281648_T2",
"type": "Protein",
"text": [
"HA1"
],
"offsets": [
[
2... | [] | [
{
"id": "PMID-11281648_1",
"entity_ids": [
"PMID-11281648_T1",
"PMID-11281648_T2"
]
}
] | [] |
39 | PMID-11292861 | [
{
"id": "PMID-11292861__text",
"type": "abstract",
"text": [
"Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation. \nHypoxia-inducible factor (HIF) is a transcriptional complex that plays a central role in the regulation of gene expression by... | [
{
"id": "PMID-11292861_T1",
"type": "Protein",
"text": [
"von Hippel-Lindau"
],
"offsets": [
[
30,
47
]
],
"normalized": []
},
{
"id": "PMID-11292861_T2",
"type": "Protein",
"text": [
"von Hippel-Lindau tumor suppressor"
],
... | [
{
"id": "PMID-11292861_E1",
"type": "Hydroxylation",
"trigger": {
"text": [
"hydroxylation"
],
"offsets": [
[
652,
665
]
]
},
"arguments": [
{
"role": "Theme",
"ref_id": "PMID-11292861_T5"
},
{
... | [
{
"id": "PMID-11292861_1",
"entity_ids": [
"PMID-11292861_T2",
"PMID-11292861_T3"
]
}
] | [] |
40 | PMID-11292862 | [
{
"id": "PMID-11292862__text",
"type": "abstract",
"text": [
"HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensing. \nHIF (hypoxia-inducible factor) is a transcription factor that plays a pivotal role in cellular adaptation to changes in oxygen avail... | [
{
"id": "PMID-11292862_T1",
"type": "Protein",
"text": [
"VHL"
],
"offsets": [
[
22,
25
]
],
"normalized": []
},
{
"id": "PMID-11292862_T2",
"type": "Protein",
"text": [
"ubiquitin"
],
"offsets": [
[
312,
... | [] | [
{
"id": "PMID-11292862_1",
"entity_ids": [
"PMID-11292862_T3",
"PMID-11292862_T4"
]
}
] | [] |
41 | PMID-11306499 | [
{
"id": "PMID-11306499__text",
"type": "abstract",
"text": [
"Genetic and clinical features of human pancreatic ductal adenocarcinomas with widespread microsatellite instability. \nThe incidences of microsatellite instability (MSI) and underlying DNA mismatch repair (MMR) defects in pancreatic car... | [
{
"id": "PMID-11306499_T1",
"type": "Protein",
"text": [
"MLH1"
],
"offsets": [
[
575,
579
]
],
"normalized": []
},
{
"id": "PMID-11306499_T2",
"type": "Protein",
"text": [
"MSH2"
],
"offsets": [
[
582,
... | [
{
"id": "PMID-11306499_E1",
"type": "DNA_methylation",
"trigger": {
"text": [
"methylation"
],
"offsets": [
[
521,
532
]
]
},
"arguments": [
{
"role": "Theme",
"ref_id": "PMID-11306499_T1"
},
{
... | [] | [] |
42 | PMID-11327822 | [
{
"id": "PMID-11327822__text",
"type": "abstract",
"text": [
"The acetylation state of human fetal hemoglobin modulates the strength of its subunit interactions: long-range effects and implications for histone interactions in the nucleosome. \nThe source of the 70-fold increased tetramer strength ... | [
{
"id": "PMID-11327822_T1",
"type": "Protein",
"text": [
"histone"
],
"offsets": [
[
140,
147
]
],
"normalized": []
}
] | [] | [] | [] |
43 | PMID-11352938 | [
{
"id": "PMID-11352938__text",
"type": "abstract",
"text": [
"Synergism of Xist RNA, DNA methylation, and histone hypoacetylation in maintaining X chromosome inactivation. \nXist RNA expression, methylation of CpG islands, and hypoacetylation of histone H4 are distinguishing features of inactive X... | [
{
"id": "PMID-11352938_T1",
"type": "Protein",
"text": [
"Xist"
],
"offsets": [
[
13,
17
]
],
"normalized": []
},
{
"id": "PMID-11352938_T2",
"type": "Protein",
"text": [
"histone"
],
"offsets": [
[
44,
... | [
{
"id": "PMID-11352938_E1",
"type": "Acetylation",
"trigger": {
"text": [
"hypoacetylation"
],
"offsets": [
[
52,
67
]
]
},
"arguments": [
{
"role": "Theme",
"ref_id": "PMID-11352938_T2"
}
]
},
... | [
{
"id": "PMID-11352938_1",
"entity_ids": [
"PMID-11352938_T9",
"PMID-11352938_T10"
]
}
] | [] |
44 | PMID-11357511 | [
{
"id": "PMID-11357511__text",
"type": "abstract",
"text": [
"Expression of Pichia anomala INV1 gene in Saccharomyces cerevisiae results in two different active forms of hypoglycosylated invertase. \nThe Pichia anomala invertase gene (INV1) was introduced at different copy numbers into a sucrose-n... | [
{
"id": "PMID-11357511_T1",
"type": "Protein",
"text": [
"INV1"
],
"offsets": [
[
29,
33
]
],
"normalized": []
},
{
"id": "PMID-11357511_T2",
"type": "Protein",
"text": [
"invertase"
],
"offsets": [
[
125,
... | [
{
"id": "PMID-11357511_E1",
"type": "Glycosylation",
"trigger": {
"text": [
"hypoglycosylated"
],
"offsets": [
[
108,
124
]
]
},
"arguments": [
{
"role": "Theme",
"ref_id": "PMID-11357511_T1"
}
]
... | [
{
"id": "PMID-11357511_1",
"entity_ids": [
"PMID-11357511_T1",
"PMID-11357511_T2"
]
},
{
"id": "PMID-11357511_2",
"entity_ids": [
"PMID-11357511_T3",
"PMID-11357511_T4"
]
}
] | [] |
45 | PMID-11384967 | [
{
"id": "PMID-11384967__text",
"type": "abstract",
"text": [
"The histone acetyltransferase, hGCN5, interacts with and acetylates the HIV transactivator, Tat. \nFactor acetyltransferase activity associated with several histone acetyltransferases plays a key role in the control of transcription. He... | [
{
"id": "PMID-11384967_T1",
"type": "Protein",
"text": [
"histone"
],
"offsets": [
[
4,
11
]
],
"normalized": []
},
{
"id": "PMID-11384967_T2",
"type": "Protein",
"text": [
"GCN5"
],
"offsets": [
[
32,
... | [
{
"id": "PMID-11384967_E1",
"type": "Acetylation",
"trigger": {
"text": [
"acetylates"
],
"offsets": [
[
57,
67
]
]
},
"arguments": [
{
"role": "Theme",
"ref_id": "PMID-11384967_T3"
}
]
},
{
... | [] | [] |
46 | PMID-113854 | [
{
"id": "PMID-113854__text",
"type": "abstract",
"text": [
"Hydroxylating activity of frog epidermis tyrosinase. \nTrypsin activated in a similar way both the tyrosine hydroxylase and the dopa-oxidasa activities of frog epidermis tyrosinase. Several electron donors reduced or eliminated the lag pe... | [
{
"id": "PMID-113854_T1",
"type": "Protein",
"text": [
"tyrosinase"
],
"offsets": [
[
41,
51
]
],
"normalized": []
},
{
"id": "PMID-113854_T2",
"type": "Protein",
"text": [
"tyrosine hydroxylase"
],
"offsets": [
[
... | [] | [] | [] |
47 | PMID-11393792 | [
{
"id": "PMID-11393792__text",
"type": "abstract",
"text": [
"Canine COL1A2 mutation resulting in C-terminal truncation of pro-alpha2(I) and severe osteogenesis imperfecta. \nRNA and type I collagen were analyzed from cultured skin fibroblasts of a Beagle puppy with fractures consistent with type ... | [
{
"id": "PMID-11393792_T1",
"type": "Protein",
"text": [
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],
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[
7,
13
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],
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},
{
"id": "PMID-11393792_T2",
"type": "Protein",
"text": [
"COL1A2"
],
"offsets": [
[
381,
... | [
{
"id": "PMID-11393792_E1",
"type": "Hydroxylation",
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"text": [
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],
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[
1323,
1339
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]
},
"arguments": [
{
"role": "Theme",
"ref_id": "PMID-11393792_T7"
}
... | [] | [] |
48 | PMID-11445559 | [
{
"id": "PMID-11445559__text",
"type": "abstract",
"text": [
"Linking global histone acetylation to the transcription enhancement of X-chromosomal genes in Drosophila males. \nIt has become well established for several genes that targeting of histone acetylation to promoters is required for the ac... | [
{
"id": "PMID-11445559_T1",
"type": "Protein",
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],
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15,
22
]
],
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},
{
"id": "PMID-11445559_T2",
"type": "Protein",
"text": [
"histone"
],
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[
180,
... | [
{
"id": "PMID-11445559_E1",
"type": "Acetylation",
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],
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23,
34
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]
},
"arguments": [
{
"role": "Theme",
"ref_id": "PMID-11445559_T1"
}
]
},
{
... | [] | [] |
49 | PMID-11498546 | [
{
"id": "PMID-11498546__text",
"type": "abstract",
"text": [
"Correlation between histone lysine methylation and developmental changes at the chicken beta-globin locus. \nMethylation of histones at specific residues plays an important role in transcriptional regulation. Chromatin immunoprecipitati... | [
{
"id": "PMID-11498546_T1",
"type": "Protein",
"text": [
"histone"
],
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[
20,
27
]
],
"normalized": []
},
{
"id": "PMID-11498546_T2",
"type": "Protein",
"text": [
"beta-globin"
],
"offsets": [
[
88,
... | [
{
"id": "PMID-11498546_E1",
"type": "Methylation",
"trigger": {
"text": [
"methylation"
],
"offsets": [
[
35,
46
]
]
},
"arguments": [
{
"role": "Theme",
"ref_id": "PMID-11498546_T1"
},
{
... | [] | [] |
50 | PMID-11502179 | [
{
"id": "PMID-11502179__text",
"type": "abstract",
"text": [
"Purification and characterization of a soluble bioactive amino-terminal extracellular domain of the human thyrotropin receptor. \nThe amino-terminal ectodomain of the human TSH receptor has been expressed at the surface of CHO cells as ... | [
{
"id": "PMID-11502179_T1",
"type": "Protein",
"text": [
"thyrotropin receptor"
],
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[
106,
126
]
],
"normalized": []
},
{
"id": "PMID-11502179_T2",
"type": "Protein",
"text": [
"TSH receptor"
],
"offsets": [
... | [
{
"id": "PMID-11502179_E1",
"type": "Glycosylation",
"trigger": {
"text": [
"anchored"
],
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[
266,
274
]
]
},
"arguments": [
{
"role": "Theme",
"ref_id": "PMID-11502179_T2"
},
{
... | [] | [] |
51 | PMID-11504942 | [
{
"id": "PMID-11504942__text",
"type": "abstract",
"text": [
"HIF-1alpha binding to VHL is regulated by stimulus-sensitive proline hydroxylation. \nHypoxia-inducible factor-1alpha (HIF-1alpha) is a global transcriptional regulator of the hypoxic response. Under normoxic conditions, HIF-1alpha is r... | [
{
"id": "PMID-11504942_T1",
"type": "Protein",
"text": [
"HIF-1alpha"
],
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[
0,
10
]
],
"normalized": []
},
{
"id": "PMID-11504942_T2",
"type": "Protein",
"text": [
"VHL"
],
"offsets": [
[
22,
... | [
{
"id": "PMID-11504942_E1",
"type": "Hydroxylation",
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"text": [
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],
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[
69,
82
]
]
},
"arguments": [
{
"role": "Theme",
"ref_id": "PMID-11504942_T1"
},
{
... | [
{
"id": "PMID-11504942_1",
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"PMID-11504942_T3",
"PMID-11504942_T4"
]
},
{
"id": "PMID-11504942_2",
"entity_ids": [
"PMID-11504942_T6",
"PMID-11504942_T7"
]
}
] | [] |
52 | PMID-11513145 | [
{
"id": "PMID-11513145__text",
"type": "abstract",
"text": [
"2B4 (CD244) and CS1: novel members of the CD2 subset of the immunoglobulin superfamily molecules expressed on natural killer cells and other leukocytes. \n2B4 is a member of the CD2 subset of the immunoglobulin superfamily molecules exp... | [
{
"id": "PMID-11513145_T1",
"type": "Protein",
"text": [
"2B4"
],
"offsets": [
[
0,
3
]
],
"normalized": []
},
{
"id": "PMID-11513145_T2",
"type": "Protein",
"text": [
"CD244"
],
"offsets": [
[
5,
10
... | [] | [
{
"id": "PMID-11513145_1",
"entity_ids": [
"PMID-11513145_T1",
"PMID-11513145_T2"
]
}
] | [] |
53 | PMID-11595658 | [
{
"id": "PMID-11595658__text",
"type": "abstract",
"text": [
"N-glycosylation of CRF receptor type 1 is important for its ligand-specific interaction. \nThe corticotropin-releasing factor (CRF) receptor type 1 (CRFR1) contains five potential N-glycosylation sites: N38, N45, N78, N90, and N98. Cell... | [
{
"id": "PMID-11595658_T1",
"type": "Protein",
"text": [
"CRF receptor type 1"
],
"offsets": [
[
19,
38
]
],
"normalized": []
},
{
"id": "PMID-11595658_T2",
"type": "Protein",
"text": [
"corticotropin-releasing factor (CRF) receptor... | [
{
"id": "PMID-11595658_E1",
"type": "Glycosylation",
"trigger": {
"text": [
"N-glycosylation"
],
"offsets": [
[
0,
15
]
]
},
"arguments": [
{
"role": "Theme",
"ref_id": "PMID-11595658_T1"
}
]
}
... | [
{
"id": "PMID-11595658_1",
"entity_ids": [
"PMID-11595658_T2",
"PMID-11595658_T3"
]
},
{
"id": "PMID-11595658_2",
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"PMID-11595658_T7",
"PMID-11595658_T8"
]
},
{
"id": "PMID-11595658_3",
"entity_ids": [
"PMID-11595658_T9",
"PM... | [] |
54 | PMID-11604495 | [
{
"id": "PMID-11604495__text",
"type": "abstract",
"text": [
"Reduced rates of gene loss, gene silencing, and gene mutation in Dnmt1-deficient embryonic stem cells. \nTumor suppressor gene inactivation is a crucial event in oncogenesis. Gene inactivation mechanisms include events resulting in loss... | [
{
"id": "PMID-11604495_T1",
"type": "Protein",
"text": [
"Dnmt1"
],
"offsets": [
[
65,
70
]
],
"normalized": []
},
{
"id": "PMID-11604495_T2",
"type": "Protein",
"text": [
"Dnmt1"
],
"offsets": [
[
788,
... | [] | [] | [] |
55 | PMID-11711599 | [
{
"id": "PMID-11711599__text",
"type": "abstract",
"text": [
"Induction of hepatitis C virus E1 envelope protein-specific immune response can be enhanced by mutation of N-glycosylation sites. \nDeglycosylation of viral glycoproteins has been shown to influence the number of available epitopes and ... | [
{
"id": "PMID-11711599_T1",
"type": "Protein",
"text": [
"E1"
],
"offsets": [
[
31,
33
]
],
"normalized": []
},
{
"id": "PMID-11711599_T2",
"type": "Protein",
"text": [
"E1"
],
"offsets": [
[
373,
375
... | [
{
"id": "PMID-11711599_E1",
"type": "Glycosylation",
"trigger": {
"text": [
"N-linked glycosylation"
],
"offsets": [
[
643,
665
]
]
},
"arguments": [
{
"role": "Theme",
"ref_id": "PMID-11711599_T3"
}
... | [] | [] |
56 | PMID-11773073 | [
{
"id": "PMID-11773073__text",
"type": "abstract",
"text": [
"Absence of post-translational aspartyl beta-hydroxylation of epidermal growth factor domains in mice leads to developmental defects and an increased incidence of intestinal neoplasia. \nThe BAH genomic locus encodes three distinct prote... | [
{
"id": "PMID-11773073_T1",
"type": "Protein",
"text": [
"BAH"
],
"offsets": [
[
189,
192
]
],
"normalized": []
},
{
"id": "PMID-11773073_T2",
"type": "Protein",
"text": [
"junctin"
],
"offsets": [
[
240,
... | [
{
"id": "PMID-11773073_E1",
"type": "Hydroxylation",
"trigger": {
"text": [
"hydroxylation"
],
"offsets": [
[
784,
797
]
]
},
"arguments": [
{
"role": "Theme",
"ref_id": "PMID-11773073_T14"
},
{... | [] | [] |
57 | PMID-11791185 | [
{
"id": "PMID-11791185__text",
"type": "abstract",
"text": [
"Molecular cloning of ESET, a novel histone H3-specific methyltransferase that interacts with ERG transcription factor. \nThe ets-related gene erg encodes a transcription factor that is implicated in the control of cell growth and differ... | [
{
"id": "PMID-11791185_T1",
"type": "Protein",
"text": [
"ESET"
],
"offsets": [
[
21,
25
]
],
"normalized": []
},
{
"id": "PMID-11791185_T2",
"type": "Protein",
"text": [
"histone H3"
],
"offsets": [
[
35,
... | [
{
"id": "PMID-11791185_E1",
"type": "Methylation",
"trigger": {
"text": [
"methylation"
],
"offsets": [
[
1003,
1014
]
]
},
"arguments": [
{
"role": "Theme",
"ref_id": "PMID-11791185_T17"
}
]
},... | [
{
"id": "PMID-11791185_1",
"entity_ids": [
"PMID-11791185_T7",
"PMID-11791185_T8"
]
},
{
"id": "PMID-11791185_2",
"entity_ids": [
"PMID-11791185_T10",
"PMID-11791185_T11"
]
}
] | [] |
58 | PMID-11795592 | [
{
"id": "PMID-11795592__text",
"type": "abstract",
"text": [
"Regulation of HIF by the von Hippel-Lindau tumour suppressor: implications for cellular oxygen sensing. \nHypoxia-inducible factor (HIF) is central in coordinating many of the transcriptional adaptations to hypoxia. Composed of a hetero... | [
{
"id": "PMID-11795592_T1",
"type": "Protein",
"text": [
"von Hippel-Lindau tumour suppressor"
],
"offsets": [
[
25,
60
]
],
"normalized": []
},
{
"id": "PMID-11795592_T2",
"type": "Protein",
"text": [
"ubiquitin"
],
"offset... | [
{
"id": "PMID-11795592_E1",
"type": "Hydroxylation",
"trigger": {
"text": [
"hydroxylation"
],
"offsets": [
[
1159,
1172
]
]
},
"arguments": [
{
"role": "Theme",
"ref_id": "PMID-11795592_T8"
},
... | [
{
"id": "PMID-11795592_1",
"entity_ids": [
"PMID-11795592_T3",
"PMID-11795592_T4"
]
},
{
"id": "PMID-11795592_2",
"entity_ids": [
"PMID-11795592_T10",
"PMID-11795592_T11"
]
}
] | [] |
59 | PMID-11872960 | [
{
"id": "PMID-11872960__text",
"type": "abstract",
"text": [
"Promoter methylation status of the DNA repair genes hMLH1 and MGMT in gastric carcinoma and metaplastic mucosa. \nHypermethylation of CpG islands in the promoter region is associated with the silencing of a variety of tumor suppressor g... | [
{
"id": "PMID-11872960_T1",
"type": "Protein",
"text": [
"MLH1"
],
"offsets": [
[
53,
57
]
],
"normalized": []
},
{
"id": "PMID-11872960_T2",
"type": "Protein",
"text": [
"MGMT"
],
"offsets": [
[
62,
66... | [
{
"id": "PMID-11872960_E1",
"type": "DNA_methylation",
"trigger": {
"text": [
"methylation"
],
"offsets": [
[
9,
20
]
]
},
"arguments": [
{
"role": "Theme",
"ref_id": "PMID-11872960_T1"
},
{
... | [
{
"id": "PMID-11872960_1",
"entity_ids": [
"PMID-11872960_T3",
"PMID-11872960_T4"
]
},
{
"id": "PMID-11872960_2",
"entity_ids": [
"PMID-11872960_T5",
"PMID-11872960_T6"
]
}
] | [] |
60 | PMID-11902574 | [
{
"id": "PMID-11902574__text",
"type": "abstract",
"text": [
"Histone deacetylases and cancer: causes and therapies. \nTogether, histone acetyltransferases and histone deacetylases (HDACs) determine the acetylation status of histones. This acetylation affects the regulation of gene expression, and... | [
{
"id": "PMID-11902574_T1",
"type": "Protein",
"text": [
"Histone"
],
"offsets": [
[
0,
7
]
],
"normalized": []
},
{
"id": "PMID-11902574_T2",
"type": "Protein",
"text": [
"histone"
],
"offsets": [
[
66,
... | [
{
"id": "PMID-11902574_E1",
"type": "Acetylation",
"trigger": {
"text": [
"acetylation"
],
"offsets": [
[
140,
151
]
]
},
"arguments": [
{
"role": "Theme",
"ref_id": "PMID-11902574_T4"
}
]
},
... | [] | [] |
61 | PMID-11914074 | [
{
"id": "PMID-11914074__text",
"type": "abstract",
"text": [
"Co- and posttranslational modification of the alpha(1B)-adrenergic receptor: effects on receptor expression and function. \nWe have characterized the maturation, co- and posttranslational modifications, and functional properties of the ... | [
{
"id": "PMID-11914074_T1",
"type": "Protein",
"text": [
"alpha(1B)-adrenergic receptor"
],
"offsets": [
[
46,
75
]
],
"normalized": []
},
{
"id": "PMID-11914074_T2",
"type": "Protein",
"text": [
"alpha(1B)-adrenergic receptor"
... | [
{
"id": "PMID-11914074_E1",
"type": "Glycosylation",
"trigger": {
"text": [
"N-linked glycosylation"
],
"offsets": [
[
428,
450
]
]
},
"arguments": [
{
"role": "Theme",
"ref_id": "PMID-11914074_T3"
}
... | [] | [] |
62 | PMID-11960489 | [
{
"id": "PMID-11960489__text",
"type": "abstract",
"text": [
"Binding mode analysis of 3-(4-benzoyl-1-methyl-1H-2-pyrrolyl)-N-hydroxy-2-propenamide: a new synthetic histone deacetylase inhibitor inducing histone hyperacetylation, growth inhibition, and terminal cell differentiation. \nThe binding ... | [
{
"id": "PMID-11960489_T1",
"type": "Protein",
"text": [
"histone"
],
"offsets": [
[
103,
110
]
],
"normalized": []
},
{
"id": "PMID-11960489_T2",
"type": "Protein",
"text": [
"histone"
],
"offsets": [
[
142,
... | [
{
"id": "PMID-11960489_E1",
"type": "Acetylation",
"trigger": {
"text": [
"hyperacetylation"
],
"offsets": [
[
150,
166
]
]
},
"arguments": [
{
"role": "Theme",
"ref_id": "PMID-11960489_T2"
}
]
... | [] | [] |
63 | PMID-12042299 | [
{
"id": "PMID-12042299__text",
"type": "abstract",
"text": [
"Hypoxia-inducible factor (HIF) asparagine hydroxylase is identical to factor inhibiting HIF (FIH) and is related to the cupin structural family. \nActivity of the hypoxia-inducible factor (HIF) complex is controlled by oxygen-dependent ... | [
{
"id": "PMID-12042299_T1",
"type": "Protein",
"text": [
"Hypoxia-inducible factor (HIF) asparagine hydroxylase"
],
"offsets": [
[
0,
53
]
],
"normalized": []
},
{
"id": "PMID-12042299_T2",
"type": "Protein",
"text": [
"factor inhib... | [] | [
{
"id": "PMID-12042299_1",
"entity_ids": [
"PMID-12042299_T1",
"PMID-12042299_T2",
"PMID-12042299_T3"
]
},
{
"id": "PMID-12042299_2",
"entity_ids": [
"PMID-12042299_T5",
"PMID-12042299_T6"
]
},
{
"id": "PMID-12042299_3",
"entity_ids": [
"PM... | [] |
64 | PMID-12080085 | [
{
"id": "PMID-12080085__text",
"type": "abstract",
"text": [
"FIH-1 is an asparaginyl hydroxylase enzyme that regulates the transcriptional activity of hypoxia-inducible factor. \nMammalian cells adapt to hypoxic conditions through a transcriptional response pathway mediated by the hypoxia-inducib... | [
{
"id": "PMID-12080085_T1",
"type": "Protein",
"text": [
"FIH-1"
],
"offsets": [
[
0,
5
]
],
"normalized": []
},
{
"id": "PMID-12080085_T2",
"type": "Protein",
"text": [
"FIH-1"
],
"offsets": [
[
478,
4... | [] | [] | [] |
65 | PMID-12080182 | [
{
"id": "PMID-12080182__text",
"type": "abstract",
"text": [
"[alpha]-Secretase ADAM10 as well as [alpha]APPs is reduced in platelets and CSF of Alzheimer disease patients. \nBACKGROUND: Members of membrane-bound disintegrin metalloproteinases (ADAMs) were shown to be capable of cleaving amyloid p... | [
{
"id": "PMID-12080182_T1",
"type": "Protein",
"text": [
"ADAM10"
],
"offsets": [
[
18,
24
]
],
"normalized": []
},
{
"id": "PMID-12080182_T2",
"type": "Protein",
"text": [
"[alpha]APPs"
],
"offsets": [
[
36,
... | [] | [
{
"id": "PMID-12080182_1",
"entity_ids": [
"PMID-12080182_T3",
"PMID-12080182_T4"
]
}
] | [] |
66 | PMID-12115587 | [
{
"id": "PMID-12115587__text",
"type": "abstract",
"text": [
"Reduced expression of the insulin-induced protein 1 and p41 Arp2/3 complex genes in human gastric cancers. \nAberrantly methylated DNA fragments in a human gastric cancer were searched for by a genome-scanning method, methylation-sensit... | [
{
"id": "PMID-12115587_T1",
"type": "Protein",
"text": [
"insulin-induced protein 1"
],
"offsets": [
[
26,
51
]
],
"normalized": []
},
{
"id": "PMID-12115587_T2",
"type": "Protein",
"text": [
"p41"
],
"offsets": [
[
... | [
{
"id": "PMID-12115587_E1",
"type": "DNA_methylation",
"trigger": {
"text": [
"methylated"
],
"offsets": [
[
713,
723
]
]
},
"arguments": [
{
"role": "Theme",
"ref_id": "PMID-12115587_T9"
},
{
... | [
{
"id": "PMID-12115587_1",
"entity_ids": [
"PMID-12115587_T4",
"PMID-12115587_T5",
"PMID-12115587_T6"
]
}
] | [] |
67 | PMID-12126935 | [
{
"id": "PMID-12126935__text",
"type": "abstract",
"text": [
"The kyphoscoliotic type of Ehlers-Danlos syndrome (type VI): differential effects on the hydroxylation of lysine in collagens I and II revealed by analysis of cross-linked telopeptides from urine. \nThe kyphoscoliotic type of Ehlers-Dan... | [
{
"id": "PMID-12126935_T1",
"type": "Protein",
"text": [
"II"
],
"offsets": [
[
132,
134
]
],
"normalized": []
},
{
"id": "PMID-12126935_T2",
"type": "Protein",
"text": [
"lysyl hydroxylase 1"
],
"offsets": [
[
... | [
{
"id": "PMID-12126935_E1",
"type": "Hydroxylation",
"trigger": {
"text": [
"hydroxylation"
],
"offsets": [
[
89,
102
]
]
},
"arguments": [
{
"role": "Theme",
"ref_id": "PMID-12126935_T1"
},
{
... | [
{
"id": "PMID-12126935_1",
"entity_ids": [
"PMID-12126935_T2",
"PMID-12126935_T3"
]
}
] | [] |
68 | PMID-12154089 | [
{
"id": "PMID-12154089__text",
"type": "abstract",
"text": [
"Postsynthetic trimethylation of histone H4 at lysine 20 in mammalian tissues is associated with aging. \nMethylation of the N-terminal region of histones was first described more than 35 years ago, but its biological significance has re... | [
{
"id": "PMID-12154089_T1",
"type": "Protein",
"text": [
"histone H4"
],
"offsets": [
[
32,
42
]
],
"normalized": []
},
{
"id": "PMID-12154089_T2",
"type": "Protein",
"text": [
"histones"
],
"offsets": [
[
144,... | [
{
"id": "PMID-12154089_E1",
"type": "Methylation",
"trigger": {
"text": [
"trimethylation"
],
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[
14,
28
]
]
},
"arguments": [
{
"role": "Theme",
"ref_id": "PMID-12154089_T1"
},
{
... | [] | [] |
69 | PMID-12163655 | [
{
"id": "PMID-12163655__text",
"type": "abstract",
"text": [
"In the cystathionine beta-synthase knockout mouse, elevations in total plasma homocysteine increase tissue S-adenosylhomocysteine, but responses of S-adenosylmethionine and DNA methylation are tissue specific. \nThe cystathionine beta-s... | [
{
"id": "PMID-12163655_T1",
"type": "Protein",
"text": [
"cystathionine beta-synthase"
],
"offsets": [
[
7,
34
]
],
"normalized": []
},
{
"id": "PMID-12163655_T2",
"type": "Protein",
"text": [
"cystathionine beta-synthase"
],
... | [] | [] | [] |
70 | PMID-12171601 | [
{
"id": "PMID-12171601__text",
"type": "abstract",
"text": [
"Glycosylation of human proteinase-activated receptor-2 (hPAR2): role in cell surface expression and signalling. \nWe have analysed the role of N-linked glycosylation in regulating human proteinase-activated receptor-2 (hPAR(2)) expressi... | [
{
"id": "PMID-12171601_T1",
"type": "Protein",
"text": [
"proteinase-activated receptor-2"
],
"offsets": [
[
23,
54
]
],
"normalized": []
},
{
"id": "PMID-12171601_T2",
"type": "Protein",
"text": [
"PAR2"
],
"offsets": [
... | [
{
"id": "PMID-12171601_E1",
"type": "Glycosylation",
"trigger": {
"text": [
"Glycosylation"
],
"offsets": [
[
0,
13
]
]
},
"arguments": [
{
"role": "Theme",
"ref_id": "PMID-12171601_T1"
}
]
},
... | [
{
"id": "PMID-12171601_1",
"entity_ids": [
"PMID-12171601_T1",
"PMID-12171601_T2"
]
},
{
"id": "PMID-12171601_2",
"entity_ids": [
"PMID-12171601_T3",
"PMID-12171601_T4"
]
}
] | [] |
71 | PMID-12186410 | [
{
"id": "PMID-12186410__text",
"type": "abstract",
"text": [
"N-acetyltransferase 2 genotype-related sulfapyridine acetylation and its adverse events. \nSulfapyridine (SP), one of the metabolites of sulfasalazine (SASP), is further metabolized into N-acetylsulfapyridine (AcSP) by polymorphic N-ace... | [
{
"id": "PMID-12186410_T1",
"type": "Protein",
"text": [
"N-acetyltransferase 2"
],
"offsets": [
[
0,
21
]
],
"normalized": []
},
{
"id": "PMID-12186410_T2",
"type": "Protein",
"text": [
"N-acetyltransferase 2"
],
"offsets":... | [] | [
{
"id": "PMID-12186410_1",
"entity_ids": [
"PMID-12186410_T2",
"PMID-12186410_T3"
]
}
] | [] |
72 | PMID-12193658 | [
{
"id": "PMID-12193658__text",
"type": "abstract",
"text": [
"Histone H3 lysine 4 methylation is mediated by Set1 and promotes maintenance of active chromatin states in fission yeast. \nMethylation of histone H3 at lysine 4 (H3 Lys-4) or lysine 9 (H3 Lys-9) is known to define active and silent chr... | [
{
"id": "PMID-12193658_T1",
"type": "Protein",
"text": [
"Histone H3"
],
"offsets": [
[
0,
10
]
],
"normalized": []
},
{
"id": "PMID-12193658_T2",
"type": "Protein",
"text": [
"Set1"
],
"offsets": [
[
47,
... | [
{
"id": "PMID-12193658_E1",
"type": "Methylation",
"trigger": {
"text": [
"methylation"
],
"offsets": [
[
20,
31
]
]
},
"arguments": [
{
"role": "Theme",
"ref_id": "PMID-12193658_T1"
},
{
... | [
{
"id": "PMID-12193658_1",
"entity_ids": [
"PMID-12193658_T3",
"PMID-12193658_T4"
]
},
{
"id": "PMID-12193658_2",
"entity_ids": [
"PMID-12193658_T24",
"PMID-12193658_T25"
]
},
{
"id": "PMID-12193658_3",
"entity_ids": [
"PMID-12193658_T26",
... | [] |
73 | PMID-12215170 | [
{
"id": "PMID-12215170__text",
"type": "abstract",
"text": [
"Hypoxia-inducible factor asparaginyl hydroxylase (FIH-1) catalyses hydroxylation at the beta-carbon of asparagine-803. \nAsparagine-803 in the C-terminal transactivation domain of human hypoxia-inducible factor (HIF)-1 alpha-subunit is ... | [
{
"id": "PMID-12215170_T1",
"type": "Protein",
"text": [
"Hypoxia-inducible factor asparaginyl hydroxylase"
],
"offsets": [
[
0,
48
]
],
"normalized": []
},
{
"id": "PMID-12215170_T2",
"type": "Protein",
"text": [
"FIH-1"
],
... | [
{
"id": "PMID-12215170_E1",
"type": "Hydroxylation",
"trigger": {
"text": [
"hydroxylated"
],
"offsets": [
[
235,
247
]
]
},
"arguments": [
{
"role": "Theme",
"ref_id": "PMID-12215170_T3"
},
{
... | [
{
"id": "PMID-12215170_1",
"entity_ids": [
"PMID-12215170_T1",
"PMID-12215170_T2"
]
},
{
"id": "PMID-12215170_2",
"entity_ids": [
"PMID-12215170_T4",
"PMID-12215170_T5"
]
}
] | [] |
74 | PMID-12237810 | [
{
"id": "PMID-12237810__text",
"type": "abstract",
"text": [
"Effect of the alcohol extract of the seeds of Mucuna pruriens on free radicals and oxidative stress in albino rats. \nIn vitro and in vivo studies were made with an alcohol extract of the seeds of Mucuna pruriens (Fabaceae) to investiga... | [
{
"id": "PMID-12237810_T1",
"type": "Protein",
"text": [
"GOT"
],
"offsets": [
[
1150,
1153
]
],
"normalized": []
},
{
"id": "PMID-12237810_T2",
"type": "Protein",
"text": [
"GPT"
],
"offsets": [
[
1155,
... | [] | [] | [] |
75 | PMID-12351403 | [
{
"id": "PMID-12351403__text",
"type": "abstract",
"text": [
"Induction of apoptosis of human B-CLL and ALL cells by a novel retinoid and its nonretinoidal analog. \nWe have recently described a novel retinoid 6-[3-(1-adamantyl)-4-hydroxyphenyl]-2-naphthalenecarboxylic acid (CD437/AHPN) that induc... | [
{
"id": "PMID-12351403_T1",
"type": "Protein",
"text": [
"caspase-2"
],
"offsets": [
[
749,
758
]
],
"normalized": []
},
{
"id": "PMID-12351403_T2",
"type": "Protein",
"text": [
"caspase-3"
],
"offsets": [
[
76... | [] | [] | [] |
76 | PMID-12351678 | [
{
"id": "PMID-12351678__text",
"type": "abstract",
"text": [
"Biochemical purification and pharmacological inhibition of a mammalian prolyl hydroxylase acting on hypoxia-inducible factor. \nThe product of the von Hippel-Lindau gene, pVHL, targets the alpha subunits of the heterodimeric transcripti... | [
{
"id": "PMID-12351678_T1",
"type": "Protein",
"text": [
"von Hippel-Lindau gene"
],
"offsets": [
[
146,
168
]
],
"normalized": []
},
{
"id": "PMID-12351678_T2",
"type": "Protein",
"text": [
"pVHL"
],
"offsets": [
[
... | [] | [
{
"id": "PMID-12351678_1",
"entity_ids": [
"PMID-12351678_T1",
"PMID-12351678_T2"
]
}
] | [] |
77 | PMID-12374746 | [
{
"id": "PMID-12374746__text",
"type": "abstract",
"text": [
"Control of CBP co-activating activity by arginine methylation. \nThe histone acetyltransferases CREB binding protein (CBP) and the related p300 protein function as key transcriptional co-activators in multiple pathways. In the case of t... | [
{
"id": "PMID-12374746_T1",
"type": "Protein",
"text": [
"CBP"
],
"offsets": [
[
11,
14
]
],
"normalized": []
},
{
"id": "PMID-12374746_T2",
"type": "Protein",
"text": [
"histone"
],
"offsets": [
[
68,
... | [
{
"id": "PMID-12374746_E1",
"type": "Methylation",
"trigger": {
"text": [
"methylation"
],
"offsets": [
[
50,
61
]
]
},
"arguments": [
{
"role": "Theme",
"ref_id": "PMID-12374746_T1"
},
{
... | [
{
"id": "PMID-12374746_1",
"entity_ids": [
"PMID-12374746_T3",
"PMID-12374746_T4"
]
}
] | [] |
78 | PMID-12438637 | [
{
"id": "PMID-12438637__text",
"type": "abstract",
"text": [
"The hepatitis C virus RNA-dependent RNA polymerase membrane insertion sequence is a transmembrane segment. \nThe hepatitis C virus (HCV) RNA-dependent RNA polymerase (RdRp) belongs to a class of membrane proteins termed tail-anchored pr... | [
{
"id": "PMID-12438637_T1",
"type": "Protein",
"text": [
"RNA-dependent RNA polymerase"
],
"offsets": [
[
22,
50
]
],
"normalized": []
},
{
"id": "PMID-12438637_T2",
"type": "Protein",
"text": [
"RNA-dependent RNA polymerase"
],... | [] | [
{
"id": "PMID-12438637_1",
"entity_ids": [
"PMID-12438637_T2",
"PMID-12438637_T3"
]
}
] | [] |
79 | PMID-12461688 | [
{
"id": "PMID-12461688__text",
"type": "abstract",
"text": [
"Molecular and biochemical characterisation of a novel sulphatase gene: Arylsulfatase G (ARSG). \nMolecular analysis has provided important insights into the biochemistry and genetics of the sulphatase family of enzymes. Through bioinfor... | [
{
"id": "PMID-12461688_T1",
"type": "Protein",
"text": [
"Arylsulfatase G"
],
"offsets": [
[
71,
86
]
],
"normalized": []
},
{
"id": "PMID-12461688_T2",
"type": "Protein",
"text": [
"ARSG"
],
"offsets": [
[
88,... | [
{
"id": "PMID-12461688_E1",
"type": "Glycosylation",
"trigger": {
"text": [
"glycosylation"
],
"offsets": [
[
1010,
1023
]
]
},
"arguments": [
{
"role": "Theme",
"ref_id": "PMID-12461688_T7"
}
]
... | [
{
"id": "PMID-12461688_1",
"entity_ids": [
"PMID-12461688_T1",
"PMID-12461688_T2"
]
},
{
"id": "PMID-12461688_2",
"entity_ids": [
"PMID-12461688_T3",
"PMID-12461688_T4"
]
}
] | [] |
80 | PMID-12498693 | [
{
"id": "PMID-12498693__text",
"type": "abstract",
"text": [
"Gene-specific targeting of H3K9 methylation is sufficient for initiating repression in vivo. \nCovalent modifications of chromatin have emerged as key determinants of the genome's transcriptional competence. Histone H3 lysine 9 (H3K9) m... | [
{
"id": "PMID-12498693_T1",
"type": "Protein",
"text": [
"H3"
],
"offsets": [
[
27,
29
]
],
"normalized": []
},
{
"id": "PMID-12498693_T2",
"type": "Protein",
"text": [
"Histone H3"
],
"offsets": [
[
207,
... | [
{
"id": "PMID-12498693_E1",
"type": "Methylation",
"trigger": {
"text": [
"methylation"
],
"offsets": [
[
32,
43
]
]
},
"arguments": [
{
"role": "Theme",
"ref_id": "PMID-12498693_T1"
},
{
... | [
{
"id": "PMID-12498693_1",
"entity_ids": [
"PMID-12498693_T2",
"PMID-12498693_T3"
]
},
{
"id": "PMID-12498693_2",
"entity_ids": [
"PMID-12498693_T12",
"PMID-12498693_T13"
]
}
] | [] |
81 | PMID-12519694 | [
{
"id": "PMID-12519694__text",
"type": "abstract",
"text": [
"Studies on the inhibition of human cytochromes P450 by selenocysteine Se-conjugates. \n1. To investigate whether cytochrome P450 (P450) inhibition can contribute to the chemopreventive activity of selenocysteine Se-conjugates (SeCys co... | [
{
"id": "PMID-12519694_T1",
"type": "Protein",
"text": [
"CYP1A1"
],
"offsets": [
[
435,
441
]
],
"normalized": []
},
{
"id": "PMID-12519694_T2",
"type": "Protein",
"text": [
"CYP2C9"
],
"offsets": [
[
573,
... | [] | [] | [] |
82 | PMID-12522210 | [
{
"id": "PMID-12522210__text",
"type": "abstract",
"text": [
"Identification of a lactoferrin-derived peptide possessing binding activity to hepatitis C virus E2 envelope protein. \nBovine and human lactoferrins (LF) prevent hepatitis C virus (HCV) infection in cultured human hepatocytes; the prev... | [
{
"id": "PMID-12522210_T1",
"type": "Protein",
"text": [
"lactoferrin"
],
"offsets": [
[
20,
31
]
],
"normalized": []
},
{
"id": "PMID-12522210_T2",
"type": "Protein",
"text": [
"E2"
],
"offsets": [
[
97,
... | [] | [
{
"id": "PMID-12522210_1",
"entity_ids": [
"PMID-12522210_T3",
"PMID-12522210_T4"
]
}
] | [] |
83 | PMID-12546654 | [
{
"id": "PMID-12546654__text",
"type": "abstract",
"text": [
"Glucocorticoid suppression of nuclear factor-kappa B: a role for histone modifications. \nCorticosteroids are by far the most effective treatment for chronic inflammatory diseases such as asthma. Inflammation in asthma is characterized ... | [
{
"id": "PMID-12546654_T1",
"type": "Protein",
"text": [
"histone"
],
"offsets": [
[
65,
72
]
],
"normalized": []
},
{
"id": "PMID-12546654_T2",
"type": "Protein",
"text": [
"histones"
],
"offsets": [
[
627,
... | [
{
"id": "PMID-12546654_E1",
"type": "Acetylation",
"trigger": {
"text": [
"acetylate"
],
"offsets": [
[
612,
621
]
]
},
"arguments": [
{
"role": "Theme",
"ref_id": "PMID-12546654_T2"
}
]
},
{
... | [] | [] |
84 | PMID-12558945 | [
{
"id": "PMID-12558945__text",
"type": "abstract",
"text": [
"Probing the conformational and dynamical effects of O-glycosylation within the immunodominant region of a MUC1 peptide tumor antigen. \nMUC1 mucin is a large transmembrane glycoprotein, the extracellular domain of which is formed by a r... | [
{
"id": "PMID-12558945_T1",
"type": "Protein",
"text": [
"MUC1"
],
"offsets": [
[
106,
110
]
],
"normalized": []
},
{
"id": "PMID-12558945_T2",
"type": "Protein",
"text": [
"MUC1"
],
"offsets": [
[
135,
... | [
{
"id": "PMID-12558945_E1",
"type": "Glycosylation",
"trigger": {
"text": [
"O-glycosylation"
],
"offsets": [
[
52,
67
]
]
},
"arguments": [
{
"role": "Theme",
"ref_id": "PMID-12558945_T1"
},
{
... | [
{
"id": "PMID-12558945_1",
"entity_ids": [
"PMID-12558945_T11",
"PMID-12558945_T12"
]
},
{
"id": "PMID-12558945_2",
"entity_ids": [
"PMID-12558945_T13",
"PMID-12558945_T14"
]
},
{
"id": "PMID-12558945_3",
"entity_ids": [
"PMID-12558945_T15",
... | [] |
85 | PMID-12574507 | [
{
"id": "PMID-12574507__text",
"type": "abstract",
"text": [
"Lysine-79 of histone H3 is hypomethylated at silenced loci in yeast and mammalian cells: a potential mechanism for position-effect variegation. \nMethylation of lysine-79 (K79) within the globular domain of histone H3 by Dot1 methylase ... | [
{
"id": "PMID-12574507_T1",
"type": "Protein",
"text": [
"histone H3"
],
"offsets": [
[
13,
23
]
],
"normalized": []
},
{
"id": "PMID-12574507_T2",
"type": "Protein",
"text": [
"histone H3"
],
"offsets": [
[
20... | [
{
"id": "PMID-12574507_E1",
"type": "Methylation",
"trigger": {
"text": [
"hypomethylated"
],
"offsets": [
[
27,
41
]
]
},
"arguments": [
{
"role": "Theme",
"ref_id": "PMID-12574507_T1"
},
{
... | [
{
"id": "PMID-12574507_1",
"entity_ids": [
"PMID-12574507_T19",
"PMID-12574507_T20"
]
}
] | [] |
86 | PMID-12586829 | [
{
"id": "PMID-12586829__text",
"type": "abstract",
"text": [
"Cyclosporin A prevents the hypoxic adaptation by activating hypoxia-inducible factor-1alpha Pro-564 hydroxylation. \nThe mechanism by which hypoxia induces gene transcription involves the inhibition of hypoxia-inducible factor (HIF)-1al... | [
{
"id": "PMID-12586829_T1",
"type": "Protein",
"text": [
"hypoxia-inducible factor-1alpha"
],
"offsets": [
[
60,
91
]
],
"normalized": []
},
{
"id": "PMID-12586829_T2",
"type": "Protein",
"text": [
"hypoxia-inducible factor (HIF)-1a... | [
{
"id": "PMID-12586829_E1",
"type": "Hydroxylation",
"trigger": {
"text": [
"hydroxylation"
],
"offsets": [
[
100,
113
]
]
},
"arguments": [
{
"role": "Theme",
"ref_id": "PMID-12586829_T1"
},
{
... | [
{
"id": "PMID-12586829_1",
"entity_ids": [
"PMID-12586829_T10",
"PMID-12586829_T11"
]
}
] | [] |
87 | PMID-12606569 | [
{
"id": "PMID-12606569__text",
"type": "abstract",
"text": [
"A role for N-glycanase in the cytosolic turnover of glycoproteins. \nSuccessful maturation determines the intracellular fate of secretory and membrane proteins in the endoplasmic reticulum (ER). Failure of proteins to fold or assemble p... | [
{
"id": "PMID-12606569_T1",
"type": "Protein",
"text": [
"PNG1"
],
"offsets": [
[
592,
596
]
],
"normalized": []
},
{
"id": "PMID-12606569_T2",
"type": "Protein",
"text": [
"PNG1"
],
"offsets": [
[
766,
... | [] | [] | [] |
88 | PMID-12620295 | [
{
"id": "PMID-12620295__text",
"type": "abstract",
"text": [
"Preclinical evaluation of antineoplastic activity of inhibitors of DNA methylation (5-aza-2'-deoxycytidine) and histone deacetylation (trichostatin A, depsipeptide) in combination against myeloid leukemic cells. \nDuring the development... | [
{
"id": "PMID-12620295_T1",
"type": "Protein",
"text": [
"histone"
],
"offsets": [
[
112,
119
]
],
"normalized": []
},
{
"id": "PMID-12620295_T2",
"type": "Protein",
"text": [
"histone"
],
"offsets": [
[
398,
... | [
{
"id": "PMID-12620295_E1",
"type": "Deacetylation",
"trigger": {
"text": [
"deacetylation"
],
"offsets": [
[
120,
133
]
]
},
"arguments": [
{
"role": "Theme",
"ref_id": "PMID-12620295_T1"
}
]
}... | [] | [] |
89 | PMID-12634321 | [
{
"id": "PMID-12634321__text",
"type": "abstract",
"text": [
"Complex-type biantennary N-glycans of recombinant human transferrin from Trichoplusia ni insect cells expressing mammalian [beta]-1,4-galactosyltransferase and [beta]-1,2-N-acetylglucosaminyltransferase II. \nA novel recombinant baculov... | [
{
"id": "PMID-12634321_T1",
"type": "Protein",
"text": [
"transferrin"
],
"offsets": [
[
56,
67
]
],
"normalized": []
},
{
"id": "PMID-12634321_T2",
"type": "Protein",
"text": [
"[beta]-1,2-N-acetylglucosaminyltransferase II"
],... | [] | [] | [] |
90 | PMID-12646245 | [
{
"id": "PMID-12646245__text",
"type": "abstract",
"text": [
"Overexpression of the CT GalNAc transferase inhibits muscular dystrophy in a cleavage-resistant dystroglycan mutant mouse. \nTransgenic mice that express dystroglycan containing a serine to alanine point mutation at the normal site of c... | [
{
"id": "PMID-12646245_T1",
"type": "Protein",
"text": [
"CT GalNAc transferase"
],
"offsets": [
[
22,
43
]
],
"normalized": []
},
{
"id": "PMID-12646245_T2",
"type": "Protein",
"text": [
"dystroglycan"
],
"offsets": [
... | [
{
"id": "PMID-12646245_E1",
"type": "Glycosylation",
"trigger": {
"text": [
"glycosylated"
],
"offsets": [
[
1283,
1295
]
]
},
"arguments": [
{
"role": "Theme",
"ref_id": "PMID-12646245_T13"
}
]
... | [] | [] |
91 | PMID-12694398 | [
{
"id": "PMID-12694398__text",
"type": "abstract",
"text": [
"Characterization of two novel proteins, NgRH1 and NgRH2, structurally and biochemically homologous to the Nogo-66 receptor. \nNogo-66 receptor (NgR) has recently been identified as the neuronal receptor of the myelin-associated proteins... | [
{
"id": "PMID-12694398_T1",
"type": "Protein",
"text": [
"NgRH1"
],
"offsets": [
[
40,
45
]
],
"normalized": []
},
{
"id": "PMID-12694398_T2",
"type": "Protein",
"text": [
"NgRH2"
],
"offsets": [
[
50,
... | [
{
"id": "PMID-12694398_E1",
"type": "Glycosylation",
"trigger": {
"text": [
"N-glycosylated"
],
"offsets": [
[
1083,
1097
]
]
},
"arguments": [
{
"role": "Theme",
"ref_id": "PMID-12694398_T17"
}
]... | [
{
"id": "PMID-12694398_1",
"entity_ids": [
"PMID-12694398_T4",
"PMID-12694398_T5"
]
},
{
"id": "PMID-12694398_2",
"entity_ids": [
"PMID-12694398_T7",
"PMID-12694398_T8"
]
},
{
"id": "PMID-12694398_3",
"entity_ids": [
"PMID-12694398_T9",
"PM... | [] |
92 | PMID-12729016 | [
{
"id": "PMID-12729016__text",
"type": "abstract",
"text": [
"Synthesis of hydroxymethylglutathione from glutathione and L-serine catalyzed by carboxypeptidase Y. \nHydroxymethylglutathione (gamma-L-glutamyl-L-cysteinyl-L-serine; hmGSH) occurs in many species belonging to the family Gramineae, but... | [
{
"id": "PMID-12729016_T1",
"type": "Protein",
"text": [
"carboxypeptidase Y"
],
"offsets": [
[
81,
99
]
],
"normalized": []
},
{
"id": "PMID-12729016_T2",
"type": "Protein",
"text": [
"carboxypeptidase Y"
],
"offsets": [
... | [] | [] | [] |
93 | PMID-12764140 | [
{
"id": "PMID-12764140__text",
"type": "abstract",
"text": [
"Transcriptional elongation by RNA polymerase II and histone methylation. \nmRNA synthesis in eukaryotic organisms is a key biological process that is regulated at multiple levels. From the covalent modifications of chromatin by a number... | [
{
"id": "PMID-12764140_T1",
"type": "Protein",
"text": [
"histone"
],
"offsets": [
[
52,
59
]
],
"normalized": []
},
{
"id": "PMID-12764140_T2",
"type": "Protein",
"text": [
"histone"
],
"offsets": [
[
828,
... | [
{
"id": "PMID-12764140_E1",
"type": "Methylation",
"trigger": {
"text": [
"methylation"
],
"offsets": [
[
60,
71
]
]
},
"arguments": [
{
"role": "Theme",
"ref_id": "PMID-12764140_T1"
}
]
},
{
... | [] | [] |
94 | PMID-12771137 | [
{
"id": "PMID-12771137__text",
"type": "abstract",
"text": [
"Prolyl hydroxylation of collagen type I is required for efficient binding to integrin alpha 1 beta 1 and platelet glycoprotein VI but not to alpha 2 beta 1. \nCollagen is a potent adhesive substrate for cells, an event essentially media... | [
{
"id": "PMID-12771137_T1",
"type": "Protein",
"text": [
"integrin alpha 1"
],
"offsets": [
[
77,
93
]
],
"normalized": []
},
{
"id": "PMID-12771137_T2",
"type": "Protein",
"text": [
"beta 1"
],
"offsets": [
[
... | [] | [] | [] |
95 | PMID-12795616 | [
{
"id": "PMID-12795616__text",
"type": "abstract",
"text": [
"Mechanism, mutagenesis, and chemical rescue of a beta-mannosidase from cellulomonas fimi. \nThe chemical mechanism of a retaining beta-mannosidase from Cellulomonas fimi has been characterized through steady-state kinetic analyses with ... | [
{
"id": "PMID-12795616_T1",
"type": "Protein",
"text": [
"beta-mannosidase"
],
"offsets": [
[
49,
65
]
],
"normalized": []
},
{
"id": "PMID-12795616_T2",
"type": "Protein",
"text": [
"beta-mannosidase"
],
"offsets": [
... | [] | [] | [] |
96 | PMID-12871464 | [
{
"id": "PMID-12871464__text",
"type": "abstract",
"text": [
"Occurrence of O-linked Xyl-GlcNAc and Xyl-Glc disaccharides in trocarin, a factor Xa homolog from snake venom. \nTrocarin is a 46515-Da group D prothrombin-activating glycoprotein from the venom of the Australian elapid, Tropidechis car... | [
{
"id": "PMID-12871464_T1",
"type": "Protein",
"text": [
"trocarin"
],
"offsets": [
[
63,
71
]
],
"normalized": []
},
{
"id": "PMID-12871464_T2",
"type": "Protein",
"text": [
"factor Xa"
],
"offsets": [
[
75,
... | [
{
"id": "PMID-12871464_E1",
"type": "Glycosylation",
"trigger": {
"text": [
"O-linked"
],
"offsets": [
[
14,
22
]
]
},
"arguments": [
{
"role": "Theme",
"ref_id": "PMID-12871464_T1"
},
{
... | [] | [] |
97 | PMID-12871934 | [
{
"id": "PMID-12871934__text",
"type": "abstract",
"text": [
"Differential glycosylation regulates processing of lipoprotein receptors by gamma-secretase. \nThe low density lipoprotein (LDL) receptor-related protein 1 (LRP1) belongs to a growing number of cell surface proteins that undergo regulat... | [
{
"id": "PMID-12871934_T1",
"type": "Protein",
"text": [
"low density lipoprotein (LDL) receptor-related protein 1"
],
"offsets": [
[
98,
154
]
],
"normalized": []
},
{
"id": "PMID-12871934_T2",
"type": "Protein",
"text": [
"LRP1"
... | [
{
"id": "PMID-12871934_E1",
"type": "Glycosylation",
"trigger": {
"text": [
"glycosylated"
],
"offsets": [
[
418,
430
]
]
},
"arguments": [
{
"role": "Theme",
"ref_id": "PMID-12871934_T3"
}
]
},... | [
{
"id": "PMID-12871934_1",
"entity_ids": [
"PMID-12871934_T1",
"PMID-12871934_T2"
]
},
{
"id": "PMID-12871934_2",
"entity_ids": [
"PMID-12871934_T4",
"PMID-12871934_T5"
]
}
] | [] |
98 | PMID-12894892 | [
{
"id": "PMID-12894892__text",
"type": "abstract",
"text": [
"Inactivation of p16 gene in leukemia. \nTo determine the frequency of p16 gene inactivation in leukemia cells, and to evaluate their value in the prediction of their clinical outcome. Bone marrow or peripheral blood samples from 48 pati... | [
{
"id": "PMID-12894892_T1",
"type": "Protein",
"text": [
"p16"
],
"offsets": [
[
16,
19
]
],
"normalized": []
},
{
"id": "PMID-12894892_T2",
"type": "Protein",
"text": [
"p16"
],
"offsets": [
[
69,
72
... | [
{
"id": "PMID-12894892_E1",
"type": "DNA_methylation",
"trigger": {
"text": [
"methylation"
],
"offsets": [
[
400,
411
]
]
},
"arguments": [
{
"role": "Theme",
"ref_id": "PMID-12894892_T4"
}
]
}... | [] | [] |
99 | PMID-12897846 | [
{
"id": "PMID-12897846__text",
"type": "abstract",
"text": [
"A haploid affair: core histone transitions during spermatogenesis. \nThe process of meiosis reduces a diploid cell to four haploid gametes and is accompanied by extensive recombination. Thus, the dynamics of chromatin during meiosis are... | [
{
"id": "PMID-12897846_T1",
"type": "Protein",
"text": [
"histone"
],
"offsets": [
[
23,
30
]
],
"normalized": []
},
{
"id": "PMID-12897846_T2",
"type": "Protein",
"text": [
"histone"
],
"offsets": [
[
607,
... | [
{
"id": "PMID-12897846_E1",
"type": "Acetylation",
"trigger": {
"text": [
"acetylation"
],
"offsets": [
[
922,
933
]
]
},
"arguments": [
{
"role": "Theme",
"ref_id": "PMID-12897846_T7"
}
]
},
... | [
{
"id": "PMID-12897846_1",
"entity_ids": [
"PMID-12897846_T7",
"PMID-12897846_T8"
]
},
{
"id": "PMID-12897846_2",
"entity_ids": [
"PMID-12897846_T9",
"PMID-12897846_T11"
]
},
{
"id": "PMID-12897846_3",
"entity_ids": [
"PMID-12897846_T10",
"... | [] |
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