id stringlengths 1 3 | document_id stringlengths 11 13 | passages list | entities list | events list | coreferences list | relations list |
|---|---|---|---|---|---|---|
0 | PMID-15193260 | [
{
"id": "PMID-15193260__text",
"type": "abstract",
"text": [
"Dynein light chain 1, a p21-activated kinase 1-interacting substrate, promotes cancerous phenotypes. \nWe identified dynein light chain 1 (DLC1) as a physiologic substrate of p21-activated kinase 1 (Pak1). Pak1-DLC1 interaction plays an... | [
{
"id": "PMID-15193260_T1",
"type": "Gene_or_gene_product",
"text": [
"Dynein light chain 1"
],
"offsets": [
[
0,
20
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],
"normalized": []
},
{
"id": "PMID-15193260_T2",
"type": "Gene_or_gene_product",
"text": [
"p21-activated kinas... | [
{
"id": "PMID-15193260_E1",
"type": "Binding",
"trigger": {
"text": [
"interacting"
],
"offsets": [
[
47,
58
]
]
},
"arguments": [
{
"role": "Theme",
"ref_id": "PMID-15193260_T2"
},
{
"r... | [
{
"id": "PMID-15193260_1",
"entity_ids": [
"PMID-15193260_T4",
"PMID-15193260_T5"
]
},
{
"id": "PMID-15193260_2",
"entity_ids": [
"PMID-15193260_T6",
"PMID-15193260_T7"
]
}
] | [] |
1 | PMID-10913166 | [
{
"id": "PMID-10913166__text",
"type": "abstract",
"text": [
"TEL, a putative tumor suppressor, modulates cell growth and cell morphology of ras-transformed cells while repressing the transcription of stromelysin-1. \nTEL is a member of the ETS family of transcription factors that interacts with t... | [
{
"id": "PMID-10913166_T1",
"type": "Gene_or_gene_product",
"text": [
"TEL"
],
"offsets": [
[
0,
3
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],
"normalized": []
},
{
"id": "PMID-10913166_T2",
"type": "Cancer",
"text": [
"tumor"
],
"offsets": [
[
16,
... | [
{
"id": "PMID-10913166_E1",
"type": "Regulation",
"trigger": {
"text": [
"modulates"
],
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[
34,
43
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]
},
"arguments": [
{
"role": "Cause",
"ref_id": "PMID-10913166_T1"
},
{
"... | [] | [] |
2 | PMID-12484699 | [
{
"id": "PMID-12484699__text",
"type": "abstract",
"text": [
"Regulation of transforming growth factor-beta signaling and vascular diseases.\nPURPOSE: Members of the transforming growth factor (TGF)-beta superfamily play critical roles in regulation of various cellular functions. Dysregulation of ... | [
{
"id": "PMID-12484699_T1",
"type": "Gene_or_gene_product",
"text": [
"transforming growth factor-beta"
],
"offsets": [
[
14,
45
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],
"normalized": []
},
{
"id": "PMID-12484699_T2",
"type": "Multi-tissue_structure",
"text": [
"vascu... | [
{
"id": "PMID-12484699_E1",
"type": "Regulation",
"trigger": {
"text": [
"Regulation"
],
"offsets": [
[
0,
10
]
]
},
"arguments": [
{
"role": "Theme",
"ref_id": "PMID-12484699_E2"
}
]
},
{
... | [] | [] |
3 | PMID-16268479 | [
{
"id": "PMID-16268479__text",
"type": "abstract",
"text": [
"Domain 5 of cleaved high molecular weight kininogen inhibits endothelial cell migration through Akt.\nDomain 5 (D5) of cleaved high molecular weight kininogen (HKa) inhibits angiogenesis in vivo and endothelial cell migration in vitro, ... | [
{
"id": "PMID-16268479_T1",
"type": "Gene_or_gene_product",
"text": [
"high molecular weight kininogen"
],
"offsets": [
[
20,
51
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],
"normalized": []
},
{
"id": "PMID-16268479_T2",
"type": "Cell",
"text": [
"endothelial cell"
]... | [
{
"id": "PMID-16268479_E1",
"type": "Protein_processing",
"trigger": {
"text": [
"cleaved"
],
"offsets": [
[
12,
19
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]
},
"arguments": [
{
"role": "Theme",
"ref_id": "PMID-16268479_T1"
}
]
},
... | [
{
"id": "PMID-16268479_1",
"entity_ids": [
"PMID-16268479_T4",
"PMID-16268479_T5"
]
},
{
"id": "PMID-16268479_2",
"entity_ids": [
"PMID-16268479_T12",
"PMID-16268479_T13"
]
},
{
"id": "PMID-16268479_3",
"entity_ids": [
"PMID-16268479_T14",
... | [] |
4 | PMID-11121230 | [
{
"id": "PMID-11121230__text",
"type": "abstract",
"text": [
"RNA damage and inhibition of neoplastic endothelial cell growth: effects of human and amphibian ribonucleases.\nAngiogenesis defines the many steps involved in the growth and migration of endothelial cell-derived blood vessels. This pro... | [
{
"id": "PMID-11121230_T1",
"type": "Cell",
"text": [
"neoplastic endothelial cell"
],
"offsets": [
[
29,
56
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],
"normalized": []
},
{
"id": "PMID-11121230_T2",
"type": "Organism",
"text": [
"human"
],
"offsets": [
[
... | [
{
"id": "PMID-11121230_E1",
"type": "Negative_regulation",
"trigger": {
"text": [
"inhibition"
],
"offsets": [
[
15,
25
]
]
},
"arguments": [
{
"role": "Theme",
"ref_id": "PMID-11121230_E2"
}
]
... | [
{
"id": "PMID-11121230_1",
"entity_ids": [
"PMID-11121230_T15",
"PMID-11121230_T16"
]
}
] | [] |
5 | PMID-12610665 | [
{
"id": "PMID-12610665__text",
"type": "abstract",
"text": [
"Arteriogenesis: the development and growth of collateral arteries.\nIn patients with atherosclerotic vascular diseases, collateral vessels bypassing major arterial obstructions have frequently been observed. This may explain why some pa... | [
{
"id": "PMID-12610665_T1",
"type": "Multi-tissue_structure",
"text": [
"collateral arteries"
],
"offsets": [
[
46,
65
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],
"normalized": []
},
{
"id": "PMID-12610665_T2",
"type": "Organism",
"text": [
"patients"
],
"offsets... | [
{
"id": "PMID-12610665_E1",
"type": "Blood_vessel_development",
"trigger": {
"text": [
"Arteriogenesis"
],
"offsets": [
[
0,
14
]
]
},
"arguments": [
{
"role": "Theme",
"ref_id": "PMID-12610665_T1"
}
... | [] | [] |
6 | PMID-20978953 | [
{
"id": "PMID-20978953__text",
"type": "abstract",
"text": [
"Role of stromal myofibroblasts in invasive breast cancer: stromal expression of alpha-smooth muscle actin correlates with worse clinical outcome. \nBACKGROUND: Recently, the desmoplastic reaction has been implicated as having an importa... | [
{
"id": "PMID-20978953_T1",
"type": "Cell",
"text": [
"stromal myofibroblasts"
],
"offsets": [
[
8,
30
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],
"normalized": []
},
{
"id": "PMID-20978953_T2",
"type": "Cancer",
"text": [
"breast cancer"
],
"offsets": [
[
... | [
{
"id": "PMID-20978953_E1",
"type": "Regulation",
"trigger": {
"text": [
"Role"
],
"offsets": [
[
0,
4
]
]
},
"arguments": [
{
"role": "Cause",
"ref_id": "PMID-20978953_T1"
},
{
"role": ... | [] | [] |
7 | PMID-7474113 | [
{
"id": "PMID-7474113__text",
"type": "abstract",
"text": [
"The inhibition of cultured myoblast differentiation by the simian virus 40 large T antigen occurs after myogenin expression and Rb up-regulation and is not exerted by transformation-competent cytoplasmic mutants. \nWe have investigated t... | [
{
"id": "PMID-7474113_T1",
"type": "Cell",
"text": [
"myoblast"
],
"offsets": [
[
27,
35
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],
"normalized": []
},
{
"id": "PMID-7474113_T2",
"type": "Organism",
"text": [
"simian virus 40"
],
"offsets": [
[
59,... | [
{
"id": "PMID-7474113_E1",
"type": "Negative_regulation",
"trigger": {
"text": [
"inhibition"
],
"offsets": [
[
4,
14
]
]
},
"arguments": [
{
"role": "Theme",
"ref_id": "PMID-7474113_E2"
},
{
... | [
{
"id": "PMID-7474113_1",
"entity_ids": [
"PMID-7474113_T8",
"PMID-7474113_T9"
]
}
] | [] |
8 | PMID-17462601 | [
{
"id": "PMID-17462601__text",
"type": "abstract",
"text": [
"An antibody directed against PDGF receptor beta enhances the antitumor and the anti-angiogenic activities of an anti-VEGF receptor 2 antibody.\nPlatelet-derived growth factor (PDGF) and its receptors (PDGFR) play important roles in tumo... | [
{
"id": "PMID-17462601_T1",
"type": "Gene_or_gene_product",
"text": [
"antibody directed against PDGF receptor beta"
],
"offsets": [
[
3,
47
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],
"normalized": []
},
{
"id": "PMID-17462601_T2",
"type": "Cancer",
"text": [
"tumor"
... | [
{
"id": "PMID-17462601_E1",
"type": "Positive_regulation",
"trigger": {
"text": [
"enhances"
],
"offsets": [
[
48,
56
]
]
},
"arguments": [
{
"role": "Cause",
"ref_id": "PMID-17462601_T1"
},
{
... | [
{
"id": "PMID-17462601_1",
"entity_ids": [
"PMID-17462601_T4",
"PMID-17462601_T5"
]
}
] | [] |
9 | PMID-19369582 | [
{
"id": "PMID-19369582__text",
"type": "abstract",
"text": [
"Characterization of the metabolic changes underlying growth factor angiogenic activation: identification of new potential therapeutic targets.\nAngiogenesis is a fundamental process to normal and abnormal tissue growth and repair, which... | [
{
"id": "PMID-19369582_T1",
"type": "Tissue",
"text": [
"tissue"
],
"offsets": [
[
204,
210
]
],
"normalized": []
},
{
"id": "PMID-19369582_T2",
"type": "Cell",
"text": [
"endothelial cells"
],
"offsets": [
[
2... | [
{
"id": "PMID-19369582_E1",
"type": "Blood_vessel_development",
"trigger": {
"text": [
"angiogenic"
],
"offsets": [
[
67,
77
]
]
},
"arguments": []
},
{
"id": "PMID-19369582_E2",
"type": "Positive_regulation",
"t... | [
{
"id": "PMID-19369582_1",
"entity_ids": [
"PMID-19369582_T8",
"PMID-19369582_T9"
]
},
{
"id": "PMID-19369582_2",
"entity_ids": [
"PMID-19369582_T17",
"PMID-19369582_T18"
]
},
{
"id": "PMID-19369582_3",
"entity_ids": [
"PMID-19369582_T19",
... | [] |
10 | PMID-10589785 | [
{
"id": "PMID-10589785__text",
"type": "abstract",
"text": [
"The antiangiogenic agent linomide inhibits the growth rate of von Hippel-Lindau paraganglioma xenografts to mice.\nThe aim of this study was to ascertain the potential usefulness of the antiangiogenic compound linomide for treatment of ... | [
{
"id": "PMID-10589785_T1",
"type": "Simple_chemical",
"text": [
"linomide"
],
"offsets": [
[
25,
33
]
],
"normalized": []
},
{
"id": "PMID-10589785_T2",
"type": "Cancer",
"text": [
"von Hippel-Lindau paraganglioma xenografts"
]... | [
{
"id": "PMID-10589785_E1",
"type": "Blood_vessel_development",
"trigger": {
"text": [
"angiogenic"
],
"offsets": [
[
8,
18
]
]
},
"arguments": []
},
{
"id": "PMID-10589785_E2",
"type": "Negative_regulation",
"tr... | [] | [] |
11 | PMID-12140030 | [
{
"id": "PMID-12140030__text",
"type": "abstract",
"text": [
"Optimizing treatment of choroidal neovascularization feeder vessels associated with age-related macular degeneration.\nPURPOSE: To optimize the method of treating choroidal neovascularization (CNV) associated with age-related macular de... | [
{
"id": "PMID-12140030_T1",
"type": "Multi-tissue_structure",
"text": [
"choroidal"
],
"offsets": [
[
24,
33
]
],
"normalized": []
},
{
"id": "PMID-12140030_T2",
"type": "Multi-tissue_structure",
"text": [
"feeder vessels"
],
... | [
{
"id": "PMID-12140030_E1",
"type": "Planned_process",
"trigger": {
"text": [
"treatment"
],
"offsets": [
[
11,
20
]
]
},
"arguments": [
{
"role": "Theme",
"ref_id": "PMID-12140030_E2"
}
]
},
... | [
{
"id": "PMID-12140030_1",
"entity_ids": [
"PMID-12140030_T8",
"PMID-12140030_T9"
]
},
{
"id": "PMID-12140030_2",
"entity_ids": [
"PMID-12140030_T10",
"PMID-12140030_T11"
]
}
] | [] |
12 | PMID-11238633 | [
{
"id": "PMID-11238633__text",
"type": "abstract",
"text": [
"IL-12 inhibition of endothelial cell functions and angiogenesis depends on lymphocyte-endothelial cell cross-talk.\nIn vivo IL-12-dependent tumor inhibition rests on the ability of IL-12 to activate a CD8-mediated cytotoxicity, inhibit ... | [
{
"id": "PMID-11238633_T1",
"type": "Gene_or_gene_product",
"text": [
"IL-12"
],
"offsets": [
[
0,
5
]
],
"normalized": []
},
{
"id": "PMID-11238633_T2",
"type": "Cell",
"text": [
"endothelial cell"
],
"offsets": [
[
... | [
{
"id": "PMID-11238633_E1",
"type": "Negative_regulation",
"trigger": {
"text": [
"inhibition"
],
"offsets": [
[
6,
16
]
]
},
"arguments": [
{
"role": "Cause",
"ref_id": "PMID-11238633_T1"
},
{
... | [
{
"id": "PMID-11238633_1",
"entity_ids": [
"PMID-11238633_T16",
"PMID-11238633_T15"
]
},
{
"id": "PMID-11238633_2",
"entity_ids": [
"PMID-11238633_T19",
"PMID-11238633_T18"
]
},
{
"id": "PMID-11238633_3",
"entity_ids": [
"PMID-11238633_T20",
... | [] |
13 | PMID-16310808 | [
{
"id": "PMID-16310808__text",
"type": "abstract",
"text": [
"Effect of thalidomide affecting VEGF secretion, cell migration, adhesion and capillary tube formation of human endothelial EA.hy 926 cells.\nAngiogenesis, new blood vessel formation, is a multistep process, precisely regulated by pro-an... | [
{
"id": "PMID-16310808_T1",
"type": "Simple_chemical",
"text": [
"thalidomide"
],
"offsets": [
[
10,
21
]
],
"normalized": []
},
{
"id": "PMID-16310808_T2",
"type": "Gene_or_gene_product",
"text": [
"VEGF"
],
"offsets": [
... | [
{
"id": "PMID-16310808_E1",
"type": "Regulation",
"trigger": {
"text": [
"affecting"
],
"offsets": [
[
22,
31
]
]
},
"arguments": [
{
"role": "Cause",
"ref_id": "PMID-16310808_T1"
},
{
"... | [
{
"id": "PMID-16310808_1",
"entity_ids": [
"PMID-16310808_T13",
"PMID-16310808_T14"
]
}
] | [] |
14 | PMID-16855378 | [
{
"id": "PMID-16855378__text",
"type": "abstract",
"text": [
"Differential mechanisms of radiosensitization by 2-deoxy-D-glucose in the monolayers and multicellular spheroids of a human glioma cell line.\nIn vitro studies using monolayer cultures of human tumor cell lines have shown that 2-DG sele... | [
{
"id": "PMID-16855378_T1",
"type": "Simple_chemical",
"text": [
"2-deoxy-D-glucose"
],
"offsets": [
[
49,
66
]
],
"normalized": []
},
{
"id": "PMID-16855378_T2",
"type": "Cell",
"text": [
"monolayers"
],
"offsets": [
... | [
{
"id": "PMID-16855378_E1",
"type": "Development",
"trigger": {
"text": [
"develop"
],
"offsets": [
[
445,
452
]
]
},
"arguments": [
{
"role": "Theme",
"ref_id": "PMID-16855378_T15"
}
]
},
{
... | [
{
"id": "PMID-16855378_1",
"entity_ids": [
"PMID-16855378_T25",
"PMID-16855378_T26"
]
}
] | [] |
15 | PMID-15725689 | [
{
"id": "PMID-15725689__text",
"type": "abstract",
"text": [
"Role of thrombogenic factors in the development of atherosclerosis.\nHemostatic factors play a crucial role in generating thrombotic plugs at sites of vascular damage (atherothrombosis). However, whether hemostatic factors contribute di... | [
{
"id": "PMID-15725689_T1",
"type": "Gene_or_gene_product",
"text": [
"thrombogenic factors"
],
"offsets": [
[
8,
28
]
],
"normalized": []
},
{
"id": "PMID-15725689_T2",
"type": "Gene_or_gene_product",
"text": [
"Hemostatic factors"... | [
{
"id": "PMID-15725689_E1",
"type": "Positive_regulation",
"trigger": {
"text": [
"play a crucial role"
],
"offsets": [
[
87,
106
]
]
},
"arguments": [
{
"role": "Cause",
"ref_id": "PMID-15725689_T2"
... | [
{
"id": "PMID-15725689_1",
"entity_ids": [
"PMID-15725689_T15",
"PMID-15725689_T16"
]
}
] | [] |
16 | PMID-9206208 | [
{
"id": "PMID-9206208__text",
"type": "abstract",
"text": [
"[Expression of metastasis suppressor gene nm23 in human hepatocellular carcinoma]. \nFor the purpose of investigating the relationship between the metastatic potential of the tumor as well as the expression of nm23-H1 mRNA, and for deter... | [
{
"id": "PMID-9206208_T1",
"type": "Gene_or_gene_product",
"text": [
"nm23"
],
"offsets": [
[
42,
46
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],
"normalized": []
},
{
"id": "PMID-9206208_T2",
"type": "Organism",
"text": [
"human"
],
"offsets": [
[
5... | [
{
"id": "PMID-9206208_E1",
"type": "Gene_expression",
"trigger": {
"text": [
"Expression"
],
"offsets": [
[
1,
11
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]
},
"arguments": [
{
"role": "Theme",
"ref_id": "PMID-9206208_T1"
}
]
},
{
... | [] | [] |
17 | PMID-18662848 | [
{
"id": "PMID-18662848__text",
"type": "abstract",
"text": [
"Reversal of the malignant phenotype of ovarian cancer A2780 cells through transfection with wild-type PTEN gene. \nOBJECTIVE: PTEN (phosphatase and tensin homologue deleted on chromosome 10) is a tumor suppressor gene identified on huma... | [
{
"id": "PMID-18662848_T1",
"type": "Cell",
"text": [
"ovarian cancer A2780 cells"
],
"offsets": [
[
39,
65
]
],
"normalized": []
},
{
"id": "PMID-18662848_T2",
"type": "Gene_or_gene_product",
"text": [
"PTEN"
],
"offsets": ... | [
{
"id": "PMID-18662848_E1",
"type": "Planned_process",
"trigger": {
"text": [
"transfection"
],
"offsets": [
[
74,
86
]
]
},
"arguments": [
{
"role": "Theme",
"ref_id": "PMID-18662848_T1"
},
{
... | [
{
"id": "PMID-18662848_1",
"entity_ids": [
"PMID-18662848_T3",
"PMID-18662848_T4"
]
}
] | [] |
18 | PMID-2541348 | [
{
"id": "PMID-2541348__text",
"type": "abstract",
"text": [
"Energy supply of the mitotic cell cycle and the Na+/H+-antiport in ascites tumors.\nThe activation of Na+ transport is due to the exchange of protons formed via glucose conversion into lactate for Na+, i.e., to the stimulation of the Na+... | [
{
"id": "PMID-2541348_T1",
"type": "Simple_chemical",
"text": [
"Na+"
],
"offsets": [
[
48,
51
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],
"normalized": []
},
{
"id": "PMID-2541348_T2",
"type": "Simple_chemical",
"text": [
"H+"
],
"offsets": [
[
52,... | [
{
"id": "PMID-2541348_E1",
"type": "Localization",
"trigger": {
"text": [
"antiport"
],
"offsets": [
[
55,
63
]
]
},
"arguments": [
{
"role": "Theme",
"ref_id": "PMID-2541348_T1"
},
{
"r... | [] | [] |
19 | PMID-10771470 | [
{
"id": "PMID-10771470__text",
"type": "abstract",
"text": [
"Active hair growth (anagen) is associated with angiogenesis.\nAfter the completion of skin development, angiogenesis, i.e., the growth of new capillaries from pre-existing blood vessels, is held to occur in the skin only under pathologi... | [
{
"id": "PMID-10771470_T1",
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... | [] |
21 | PMID-20676141 | [
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22 | PMID-12823209 | [
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23 | PMID-10487573 | [
{
"id": "PMID-10487573__text",
"type": "abstract",
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"role": "AtLoc",
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... | [] | [] |
24 | PMID-21135106 | [
{
"id": "PMID-21135106__text",
"type": "abstract",
"text": [
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{
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25 | PMID-15327827 | [
{
"id": "PMID-15327827__text",
"type": "abstract",
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... | [] | [] |
26 | PMID-1505125 | [
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27 | PMID-11587364 | [
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... | [
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... | [] |
28 | PMID-10978899 | [
{
"id": "PMID-10978899__text",
"type": "abstract",
"text": [
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"type": "Cell",
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] | [] |
29 | PMID-2314900 | [
{
"id": "PMID-2314900__text",
"type": "abstract",
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{
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... | [
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"arguments": [
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},
... | [] | [] |
30 | PMID-16398404 | [
{
"id": "PMID-16398404__text",
"type": "abstract",
"text": [
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{
"id": "PMID-16398404_T1",
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},
{
"id": "PMID-16398404_T2",
"type": "Gene_or_gene_product",
"text": [
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],
... | [
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]
},
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... | [] |
31 | PMID-19236257 | [
{
"id": "PMID-19236257__text",
"type": "abstract",
"text": [
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"type": "Simple_chemical",
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... | [
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"id": "PMID-19236257_E1",
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}
] | [] |
32 | PMID-9778569 | [
{
"id": "PMID-9778569__text",
"type": "abstract",
"text": [
"Glucose and lactate metabolism in C6 glioma cells: evidence for the preferential utilization of lactate for cell oxidative metabolism.\n13C and 1H nuclear magnetic resonance spectroscopy (NMR) was used to investigate the metabolism of L-... | [
{
"id": "PMID-9778569_T1",
"type": "Simple_chemical",
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],
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0,
7
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},
{
"id": "PMID-9778569_T2",
"type": "Simple_chemical",
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[
... | [
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"id": "PMID-9778569_E1",
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20,
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},
"arguments": [
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"role": "Theme",
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}
]
},
{
... | [] | [] |
33 | PMID-17960624 | [
{
"id": "PMID-17960624__text",
"type": "abstract",
"text": [
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{
"id": "PMID-17960624_T1",
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0,
15
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},
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"id": "PMID-17960624_T2",
"type": "Gene_or_gene_product",
"text": [
"hCAP-18"
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... | [
{
"id": "PMID-17960624_E1",
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"text": [
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16,
27
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]
},
"arguments": [
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"role": "Theme",
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},
... | [
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}
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34 | PMID-17662274 | [
{
"id": "PMID-17662274__text",
"type": "abstract",
"text": [
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{
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"type": "Gene_or_gene_product",
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],
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},
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"type": "Gene_or_gene_product",
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],
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12,
24
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},
"arguments": [
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"role": "Theme",
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},
... | [
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"PMID-17662274_T12"
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}
] | [] |
35 | PMID-9840923 | [
{
"id": "PMID-9840923__text",
"type": "abstract",
"text": [
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{
"id": "PMID-9840923_T1",
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"text": [
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0,
6
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},
{
"id": "PMID-9840923_T2",
"type": "Tissue",
"text": [
"retinal pigment epithelium"
],
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[
... | [
{
"id": "PMID-9840923_E1",
"type": "Metastasis",
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},
"arguments": [
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"role": "Theme",
"ref_id": "PMID-9840923_T1"
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{
"... | [
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"PMID-9840923_T16",
"PMID-9... | [] |
36 | PMID-3492269 | [
{
"id": "PMID-3492269__text",
"type": "abstract",
"text": [
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{
"id": "PMID-3492269_T1",
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"type": "Organism",
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... | [
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{
"id": "PMID-3492269_2",
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"PMID-3492269_T12"
]
}
] | [] |
37 | PMID-10890377 | [
{
"id": "PMID-10890377__text",
"type": "abstract",
"text": [
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{
"id": "PMID-10890377_T1",
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13,
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},
{
"id": "PMID-10890377_T2",
"type": "Gene_or_gene_product",
"text": [
"S-100beta"
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... | [
{
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"arguments": [
{
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"... | [
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"id": "PMID-10890377_1",
"entity_ids": [
"PMID-10890377_T10",
"PMID-10890377_T11"
]
}
] | [] |
38 | PMID-8633524 | [
{
"id": "PMID-8633524__text",
"type": "abstract",
"text": [
"Pancreatic somatostatin-secreting gangliocytic paraganglioma with lymph node metastases. \nGangliocytic paraganglioma (GPG) with local lymph node metastasis was found in the pancreas of a 74-yr-old female who presented with diarrhea, ste... | [
{
"id": "PMID-8633524_T1",
"type": "Organ",
"text": [
"Pancreatic"
],
"offsets": [
[
0,
10
]
],
"normalized": []
},
{
"id": "PMID-8633524_T2",
"type": "Gene_or_gene_product",
"text": [
"somatostatin"
],
"offsets": [
[
... | [
{
"id": "PMID-8633524_E1",
"type": "Localization",
"trigger": {
"text": [
"secreting"
],
"offsets": [
[
24,
33
]
]
},
"arguments": [
{
"role": "Theme",
"ref_id": "PMID-8633524_T2"
}
]
},
{
... | [
{
"id": "PMID-8633524_1",
"entity_ids": [
"PMID-8633524_T5",
"PMID-8633524_T6"
]
}
] | [] |
39 | PMID-3027568 | [
{
"id": "PMID-3027568__text",
"type": "abstract",
"text": [
"Elevated levels of diacylglycerol and decreased phorbol ester sensitivity in ras-transformed fibroblasts. \nDiacylglycerol (DG) plays a central role in phospholipid metabolism and is an endogenous activator of protein kinase C. We have s... | [
{
"id": "PMID-3027568_T1",
"type": "Simple_chemical",
"text": [
"diacylglycerol"
],
"offsets": [
[
19,
33
]
],
"normalized": []
},
{
"id": "PMID-3027568_T2",
"type": "Simple_chemical",
"text": [
"phorbol ester"
],
"offsets":... | [
{
"id": "PMID-3027568_E1",
"type": "Planned_process",
"trigger": {
"text": [
"transformed"
],
"offsets": [
[
81,
92
]
]
},
"arguments": [
{
"role": "Theme",
"ref_id": "PMID-3027568_T4"
},
{
... | [
{
"id": "PMID-3027568_1",
"entity_ids": [
"PMID-3027568_T5",
"PMID-3027568_T6"
]
},
{
"id": "PMID-3027568_2",
"entity_ids": [
"PMID-3027568_T13",
"PMID-3027568_T14"
]
}
] | [] |
40 | PMID-16740157 | [
{
"id": "PMID-16740157__text",
"type": "abstract",
"text": [
"Hyperfibrinogenemia is associated with lymphatic as well as hematogenous metastasis and worse clinical outcome in T2 gastric cancer. \nBACKGROUND: Abnormal hemostasis in cancer patients has previously been described, however the correla... | [
{
"id": "PMID-16740157_T1",
"type": "Multi-tissue_structure",
"text": [
"lymphatic"
],
"offsets": [
[
39,
48
]
],
"normalized": []
},
{
"id": "PMID-16740157_T2",
"type": "Cancer",
"text": [
"T2 gastric cancer"
],
"offsets": ... | [
{
"id": "PMID-16740157_E1",
"type": "Metastasis",
"trigger": {
"text": [
"metastasis"
],
"offsets": [
[
73,
83
]
]
},
"arguments": [
{
"role": "ToLoc",
"ref_id": "PMID-16740157_T1"
},
{
... | [] | [] |
41 | PMID-16893130 | [
{
"id": "PMID-16893130__text",
"type": "abstract",
"text": [
"[Autologous bone marrow stem cell or peripheral blood endothelial progenitor cell therapy in patients with peripheral limb ischaemia]\nNo effective medical therapies have been developed sofar to enhance blood flow in the legs of patient... | [
{
"id": "PMID-16893130_T1",
"type": "Cell",
"text": [
"bone marrow stem cell"
],
"offsets": [
[
12,
33
]
],
"normalized": []
},
{
"id": "PMID-16893130_T2",
"type": "Cell",
"text": [
"peripheral blood endothelial progenitor cell"
... | [
{
"id": "PMID-16893130_E1",
"type": "Planned_process",
"trigger": {
"text": [
"therapy"
],
"offsets": [
[
82,
89
]
]
},
"arguments": [
{
"role": "Theme",
"ref_id": "PMID-16893130_T3"
},
{
... | [] | [] |
42 | PMID-19050907 | [
{
"id": "PMID-19050907__text",
"type": "abstract",
"text": [
"Evaluation of electrical stimulation for ischemic wound therapy: a feasibility study using the lapine wound model.\nChronic wounds are a major secondary complication for many people with impaired mobility. Electrical stimulation (ES) ha... | [
{
"id": "PMID-19050907_T1",
"type": "Pathological_formation",
"text": [
"wound"
],
"offsets": [
[
50,
55
]
],
"normalized": []
},
{
"id": "PMID-19050907_T2",
"type": "Organism",
"text": [
"lapine"
],
"offsets": [
[
... | [
{
"id": "PMID-19050907_E1",
"type": "Gene_expression",
"trigger": {
"text": [
"expression"
],
"offsets": [
[
1292,
1302
]
]
},
"arguments": [
{
"role": "Theme",
"ref_id": "PMID-19050907_T19"
}
]
... | [
{
"id": "PMID-19050907_1",
"entity_ids": [
"PMID-19050907_T13",
"PMID-19050907_T14"
]
},
{
"id": "PMID-19050907_2",
"entity_ids": [
"PMID-19050907_T15",
"PMID-19050907_T16"
]
},
{
"id": "PMID-19050907_3",
"entity_ids": [
"PMID-19050907_T17",
... | [] |
43 | PMID-19422607 | [
{
"id": "PMID-19422607__text",
"type": "abstract",
"text": [
"Met amplification and tumor progression in Cdkn2a-deficient melanocytes. \nWhile many genetic alterations have been identified in melanoma, the relevant molecular events that contribute to disease progression are poorly understood. Most... | [
{
"id": "PMID-19422607_T1",
"type": "Gene_or_gene_product",
"text": [
"Met"
],
"offsets": [
[
0,
3
]
],
"normalized": []
},
{
"id": "PMID-19422607_T2",
"type": "Cancer",
"text": [
"tumor"
],
"offsets": [
[
22,
... | [
{
"id": "PMID-19422607_E1",
"type": "Mutation",
"trigger": {
"text": [
"amplification"
],
"offsets": [
[
4,
17
]
]
},
"arguments": [
{
"role": "Theme",
"ref_id": "PMID-19422607_T1"
}
]
},
{
... | [] | [] |
44 | PMID-7566959 | [
{
"id": "PMID-7566959__text",
"type": "abstract",
"text": [
"Bicistronic retroviral vector reveals capacity of v-erbA to induce erythroleukemia and to co-operate with v-myb. \nPrevious studies have shown that v-erbA and v-myb can induce the proliferation of avian erythroid cells in culture. To stu... | [
{
"id": "PMID-7566959_T1",
"type": "Gene_or_gene_product",
"text": [
"v-erbA"
],
"offsets": [
[
50,
56
]
],
"normalized": []
},
{
"id": "PMID-7566959_T2",
"type": "Cancer",
"text": [
"erythroleukemia"
],
"offsets": [
[... | [
{
"id": "PMID-7566959_E1",
"type": "Positive_regulation",
"trigger": {
"text": [
"induce"
],
"offsets": [
[
60,
66
]
]
},
"arguments": [
{
"role": "Cause",
"ref_id": "PMID-7566959_T1"
},
{
... | [] | [] |
45 | PMID-12724285 | [
{
"id": "PMID-12724285__text",
"type": "abstract",
"text": [
"Possible role of cyclooxygenase II in the acquisition of ovarian luteal function in rodents.\nThe development of the corpus luteum (CL), which involves angiogenesis, is essential for the establishment of early pregnancy. We investigated... | [
{
"id": "PMID-12724285_T1",
"type": "Gene_or_gene_product",
"text": [
"cyclooxygenase II"
],
"offsets": [
[
17,
34
]
],
"normalized": []
},
{
"id": "PMID-12724285_T2",
"type": "Multi-tissue_structure",
"text": [
"ovarian luteal"
... | [
{
"id": "PMID-12724285_E1",
"type": "Development",
"trigger": {
"text": [
"development"
],
"offsets": [
[
97,
108
]
]
},
"arguments": [
{
"role": "Theme",
"ref_id": "PMID-12724285_T3"
}
]
},
{... | [
{
"id": "PMID-12724285_1",
"entity_ids": [
"PMID-12724285_T3",
"PMID-12724285_T4"
]
}
] | [] |
46 | PMID-6312919 | [
{
"id": "PMID-6312919__text",
"type": "abstract",
"text": [
"The genetics of transformation by SV 40. \nExperiments using the tsA 58 allele of the SV 40-A gene have demonstrated that the SV 40 large T-antigen is strictly required both for immortalization and induction anchorage independence of cel... | [
{
"id": "PMID-6312919_T1",
"type": "Organism",
"text": [
"SV 40"
],
"offsets": [
[
34,
39
]
],
"normalized": []
},
{
"id": "PMID-6312919_T2",
"type": "Gene_or_gene_product",
"text": [
"tsA 58"
],
"offsets": [
[
... | [
{
"id": "PMID-6312919_E1",
"type": "Cell_transformation",
"trigger": {
"text": [
"transformation"
],
"offsets": [
[
16,
30
]
]
},
"arguments": []
},
{
"id": "PMID-6312919_E2",
"type": "Positive_regulation",
"trig... | [] | [] |
47 | PMID-19605361 | [
{
"id": "PMID-19605361__text",
"type": "abstract",
"text": [
"MEK5/ERK5 signaling modulates endothelial cell migration and focal contact turnover.\nThe formation of new blood vessels from pre-existing ones requires highly coordinated restructuring of endothelial cells (EC) and the surrounding extr... | [
{
"id": "PMID-19605361_T1",
"type": "Gene_or_gene_product",
"text": [
"MEK5"
],
"offsets": [
[
0,
4
]
],
"normalized": []
},
{
"id": "PMID-19605361_T2",
"type": "Gene_or_gene_product",
"text": [
"ERK5"
],
"offsets": [
... | [
{
"id": "PMID-19605361_E1",
"type": "Pathway",
"trigger": {
"text": [
"signaling"
],
"offsets": [
[
10,
19
]
]
},
"arguments": [
{
"role": "Participant",
"ref_id": "PMID-19605361_T1"
},
{
... | [
{
"id": "PMID-19605361_1",
"entity_ids": [
"PMID-19605361_T6",
"PMID-19605361_T7"
]
}
] | [] |
48 | PMID-12556444 | [
{
"id": "PMID-12556444__text",
"type": "abstract",
"text": [
"Inhibition of glucose metabolism sensitizes tumor cells to death receptor-triggered apoptosis through enhancement of death-inducing signaling complex formation and apical procaspase-8 processing. \nTumors display a high rate of glucose ... | [
{
"id": "PMID-12556444_T1",
"type": "Simple_chemical",
"text": [
"glucose"
],
"offsets": [
[
14,
21
]
],
"normalized": []
},
{
"id": "PMID-12556444_T2",
"type": "Cell",
"text": [
"tumor cells"
],
"offsets": [
[
... | [
{
"id": "PMID-12556444_E1",
"type": "Negative_regulation",
"trigger": {
"text": [
"Inhibition"
],
"offsets": [
[
0,
10
]
]
},
"arguments": [
{
"role": "Theme",
"ref_id": "PMID-12556444_E2"
}
]
}... | [
{
"id": "PMID-12556444_1",
"entity_ids": [
"PMID-12556444_T16",
"PMID-12556444_T15"
]
}
] | [] |
49 | PMID-14652292 | [
{
"id": "PMID-14652292__text",
"type": "abstract",
"text": [
"Effects of dietary folate on ulcerative colitis-associated colorectal carcinogenesis in the interleukin 2- and beta(2)-microglobulin-deficient mice. \nFolate supplementation may reduce the risk of colorectal dysplasia and cancer in subj... | [
{
"id": "PMID-14652292_T1",
"type": "Simple_chemical",
"text": [
"folate"
],
"offsets": [
[
19,
25
]
],
"normalized": []
},
{
"id": "PMID-14652292_T2",
"type": "Pathological_formation",
"text": [
"ulcerative colitis"
],
"off... | [
{
"id": "PMID-14652292_E1",
"type": "Regulation",
"trigger": {
"text": [
"Effects"
],
"offsets": [
[
0,
7
]
]
},
"arguments": [
{
"role": "Cause",
"ref_id": "PMID-14652292_T1"
},
{
"role... | [
{
"id": "PMID-14652292_1",
"entity_ids": [
"PMID-14652292_T10",
"PMID-14652292_T11"
]
},
{
"id": "PMID-14652292_2",
"entity_ids": [
"PMID-14652292_T13",
"PMID-14652292_T14"
]
}
] | [] |
50 | PMID-16489021 | [
{
"id": "PMID-16489021__text",
"type": "abstract",
"text": [
"Runx2 and MYC collaborate in lymphoma development by suppressing apoptotic and growth arrest pathways in vivo. \nMembers of the Runx and MYC families have been implicated as collaborating oncogenes. The mechanism of this potent collabor... | [
{
"id": "PMID-16489021_T1",
"type": "Gene_or_gene_product",
"text": [
"Runx2"
],
"offsets": [
[
0,
5
]
],
"normalized": []
},
{
"id": "PMID-16489021_T2",
"type": "Gene_or_gene_product",
"text": [
"MYC"
],
"offsets": [
... | [
{
"id": "PMID-16489021_E1",
"type": "Regulation",
"trigger": {
"text": [
"collaborate"
],
"offsets": [
[
14,
25
]
]
},
"arguments": [
{
"role": "Theme",
"ref_id": "PMID-16489021_E3"
},
{
... | [] | [] |
51 | PMID-12454816 | [
{
"id": "PMID-12454816__text",
"type": "abstract",
"text": [
"Topoisomerase I protein expression in primary colorectal cancer and lymph node metastases. \nTopoisomerase I (topo I) is an important target for the treatment of malignant disease, especially colorectal cancer. Because there is little i... | [
{
"id": "PMID-12454816_T1",
"type": "Gene_or_gene_product",
"text": [
"Topoisomerase I"
],
"offsets": [
[
0,
15
]
],
"normalized": []
},
{
"id": "PMID-12454816_T2",
"type": "Cancer",
"text": [
"primary colorectal cancer"
],
... | [
{
"id": "PMID-12454816_E1",
"type": "Gene_expression",
"trigger": {
"text": [
"expression"
],
"offsets": [
[
24,
34
]
]
},
"arguments": [
{
"role": "Theme",
"ref_id": "PMID-12454816_T1"
}
]
},
... | [
{
"id": "PMID-12454816_1",
"entity_ids": [
"PMID-12454816_T4",
"PMID-12454816_T5"
]
},
{
"id": "PMID-12454816_2",
"entity_ids": [
"PMID-12454816_T15",
"PMID-12454816_T16"
]
}
] | [] |
52 | PMID-3365266 | [
{
"id": "PMID-3365266__text",
"type": "abstract",
"text": [
"Glutamine and glucose as energy substrates for Ehrlich ascites tumour cells.\nEnergy metabolism of freshly harvested Ehrlich ascites tumour cells in the presence of 5 mM glucose and/or 0.5 mM glutamine was studied. The rate of oxygen uti... | [
{
"id": "PMID-3365266_T1",
"type": "Amino_acid",
"text": [
"Glutamine"
],
"offsets": [
[
0,
9
]
],
"normalized": []
},
{
"id": "PMID-3365266_T2",
"type": "Simple_chemical",
"text": [
"glucose"
],
"offsets": [
[
... | [
{
"id": "PMID-3365266_E1",
"type": "Planned_process",
"trigger": {
"text": [
"harvested"
],
"offsets": [
[
106,
115
]
]
},
"arguments": [
{
"role": "Theme",
"ref_id": "PMID-3365266_T4"
}
]
},
... | [] | [] |
53 | PMID-10403689 | [
{
"id": "PMID-10403689__text",
"type": "abstract",
"text": [
"Immunohistochemical analysis of nm23-H1 gene product in node-positive lung cancer and lymph nodes. \nThe nm23-H1 gene product has been considered as an anti-metastatic protein and the level of its expression has been reported to correla... | [
{
"id": "PMID-10403689_T1",
"type": "Gene_or_gene_product",
"text": [
"nm23-H1"
],
"offsets": [
[
32,
39
]
],
"normalized": []
},
{
"id": "PMID-10403689_T2",
"type": "Multi-tissue_structure",
"text": [
"node"
],
"offsets": [... | [
{
"id": "PMID-10403689_E1",
"type": "Localization",
"trigger": {
"text": [
"positive"
],
"offsets": [
[
61,
69
]
]
},
"arguments": [
{
"role": "AtLoc",
"ref_id": "PMID-10403689_T2"
},
{
... | [] | [] |
54 | PMID-3985123 | [
{
"id": "PMID-3985123__text",
"type": "abstract",
"text": [
"Mast cells and tumors. The specific enhancement of tumor proliferation in vitro.\nMast cells were found to be unique among the peritoneal leukocytes by virtue of their capacity to enhance profoundly the proliferation of a variety of tumo... | [
{
"id": "PMID-3985123_T1",
"type": "Cell",
"text": [
"Mast cells"
],
"offsets": [
[
0,
10
]
],
"normalized": []
},
{
"id": "PMID-3985123_T2",
"type": "Cancer",
"text": [
"tumors"
],
"offsets": [
[
15,
2... | [
{
"id": "PMID-3985123_E1",
"type": "Positive_regulation",
"trigger": {
"text": [
"enhancement"
],
"offsets": [
[
36,
47
]
]
},
"arguments": [
{
"role": "Theme",
"ref_id": "PMID-3985123_E2"
}
]
}... | [] | [] |
55 | PMID-14613080 | [
{
"id": "PMID-14613080__text",
"type": "abstract",
"text": [
"Microvascular density and vascular endothelial growth factor immunoreactivity as predictors of regional lymph node metastasis from betel-associated oral squamous cell carcinoma. \nPURPOSE: Neovascularization has profound effects on tumo... | [
{
"id": "PMID-14613080_T1",
"type": "Tissue",
"text": [
"Microvascular"
],
"offsets": [
[
0,
13
]
],
"normalized": []
},
{
"id": "PMID-14613080_T2",
"type": "Gene_or_gene_product",
"text": [
"vascular endothelial growth factor"
... | [
{
"id": "PMID-14613080_E1",
"type": "Metastasis",
"trigger": {
"text": [
"metastasis"
],
"offsets": [
[
115,
125
]
]
},
"arguments": [
{
"role": "ToLoc",
"ref_id": "PMID-14613080_T3"
},
{
... | [
{
"id": "PMID-14613080_1",
"entity_ids": [
"PMID-14613080_T7",
"PMID-14613080_T8"
]
},
{
"id": "PMID-14613080_2",
"entity_ids": [
"PMID-14613080_T12",
"PMID-14613080_T13"
]
}
] | [] |
56 | PMID-16720995 | [
{
"id": "PMID-16720995__text",
"type": "abstract",
"text": [
"GDP and AGE receptors: mechanisms of peritoneal damage.\nLong-term peritoneal dialysis (PD) is limited by morphological changes of the peritoneal membrane. Structural changes were promoted by toxicity of glucose degradation products (GD... | [
{
"id": "PMID-16720995_T1",
"type": "Simple_chemical",
"text": [
"GDP"
],
"offsets": [
[
0,
3
]
],
"normalized": []
},
{
"id": "PMID-16720995_T2",
"type": "Simple_chemical",
"text": [
"AGE"
],
"offsets": [
[
8,... | [
{
"id": "PMID-16720995_E1",
"type": "Breakdown",
"trigger": {
"text": [
"damage"
],
"offsets": [
[
48,
54
]
]
},
"arguments": [
{
"role": "Theme",
"ref_id": "PMID-16720995_T3"
}
]
},
{
"id... | [
{
"id": "PMID-16720995_1",
"entity_ids": [
"PMID-16720995_T6",
"PMID-16720995_T7"
]
},
{
"id": "PMID-16720995_2",
"entity_ids": [
"PMID-16720995_T10",
"PMID-16720995_T11"
]
},
{
"id": "PMID-16720995_3",
"entity_ids": [
"PMID-16720995_T13",
... | [] |
57 | PMID-17145768 | [
{
"id": "PMID-17145768__text",
"type": "abstract",
"text": [
"p18Ink4c, but not p27Kip1, collaborates with Men1 to suppress neuroendocrine organ tumors. \nMutant mice lacking both cyclin-dependent kinase (CDK) inhibitors p18(Ink4c) and p27(Kip1) develop a tumor spectrum reminiscent of human multip... | [
{
"id": "PMID-17145768_T1",
"type": "Gene_or_gene_product",
"text": [
"p18Ink4c"
],
"offsets": [
[
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58 | PMID-20549676 | [
{
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... | [] | [] |
59 | PMID-17483295 | [
{
"id": "PMID-17483295__text",
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60 | PMID-19622586 | [
{
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... | [] |
61 | PMID-15623598 | [
{
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... | [] | [] |
62 | PMID-11835401 | [
{
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63 | PMID-8398065 | [
{
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... | [] | [] |
64 | PMID-15331370 | [
{
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65 | PMID-16374459 | [
{
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5... | [
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}
] | [] |
66 | PMID-14555793 | [
{
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"type": "abstract",
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{
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80,
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12,
24
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]
},
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},
{
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"type": "Breakdown",
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67 | PMID-16907772 | [
{
"id": "PMID-16907772__text",
"type": "abstract",
"text": [
"Formation of new bone during vertical distraction osteogenesis of the human mandible is related to the presence of blood vessels.\nWe examined the effect of distraction rate on blood vessel growth in intramembraneous ossification after ... | [
{
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70,
7... | [
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{
... | [] | [] |
68 | PMID-21878661 | [
{
"id": "PMID-21878661__text",
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"type": "Cell",
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69 | PMID-16204028 | [
{
"id": "PMID-16204028__text",
"type": "abstract",
"text": [
"The threshold level of adenomatous polyposis coli protein for mouse intestinal tumorigenesis. \nThe adenomatous polyposis coli (APC) gene, whose mutations are responsible for familial adenomatous polyposis, is a major negative controlle... | [
{
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},
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{
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79,
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},
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"role": "AtLoc",
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}
] | [] |
70 | PMID-21196400 | [
{
"id": "PMID-21196400__text",
"type": "abstract",
"text": [
"MTSS1: a multifunctional protein and its role in cancer invasion and metastasis. \nMTSS1 (metastasis suppressor-1) was first identified as a metastasis suppressor missing in metastatic bladder carcinoma cell lines. The down-regulation o... | [
{
"id": "PMID-21196400_T1",
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0,
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},
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"id": "PMID-21196400_T2",
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4... | [
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},
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]
}
] | [] |
71 | PMID-19695243 | [
{
"id": "PMID-19695243__text",
"type": "abstract",
"text": [
"Metronomic 5-fluorouracil, oxaliplatin and irinotecan in colorectal cancer.\nMetronomic chemotherapy (the frequent, long term, low dose administration of chemotherapeutic drugs) is a promising therapy because it enhances the anti-endoth... | [
{
"id": "PMID-19695243_T1",
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11,
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},
{
"id": "PMID-19695243_T2",
"type": "Simple_chemical",
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"oxaliplatin"
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211,
219
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]
},
"arguments": [
{
"role": "Theme",
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... | [
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{
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"... | [] |
72 | PMID-21743150 | [
{
"id": "PMID-21743150__text",
"type": "abstract",
"text": [
"[Expression of Merlin protein in non-small cell lung carcinoma and the clinical significance]. \nOBJECTIVE: To determine the expression and clinical significance of Merlin protein in non-small cell lung cancer (NSCLC). METHODS: The expr... | [
{
"id": "PMID-21743150_T1",
"type": "Gene_or_gene_product",
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15,
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},
{
"id": "PMID-21743150_T2",
"type": "Cancer",
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"non-small cell lung carcinoma"
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"text": [
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1,
11
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},
"arguments": [
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"role": "Theme",
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},
... | [
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}
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73 | PMID-15015551 | [
{
"id": "PMID-15015551__text",
"type": "abstract",
"text": [
"Morphogenesis of embryonic CNS vessels.\nThis chapter focuses on the morphology of blood vessel formation in and around the early central nervous system (CNS, i.e., brain and spinal cord) of avian embryos. We discuss cell lineages, prol... | [
{
"id": "PMID-15015551_T1",
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],
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17,
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},
{
"id": "PMID-15015551_T2",
"type": "Multi-tissue_structure",
"text": [
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{
"id": "PMID-15015551_E1",
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"text": [
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0,
13
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]
},
"arguments": [
{
"role": "Theme",
"ref_id": "PMID-15015551_T1"
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{... | [
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}
] | [] |
74 | PMID-12855648 | [
{
"id": "PMID-12855648__text",
"type": "abstract",
"text": [
"Therapeutic targeting of the survivin pathway in cancer: initiation of mitochondrial apoptosis and suppression of tumor-associated angiogenesis.\nPURPOSE: Molecular antagonists of the inhibitor of apoptosis protein survivin have shown p... | [
{
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29,
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},
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"id": "PMID-12855648_T2",
"type": "Cancer",
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"cancer"
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[
... | [
{
"id": "PMID-12855648_E1",
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12,
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]
},
"arguments": [
{
"role": "Theme",
"ref_id": "PMID-12855648_E2"
}
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},
{
... | [] | [] |
75 | PMID-11957196 | [
{
"id": "PMID-11957196__text",
"type": "abstract",
"text": [
"Risk of myelodysplastic syndrome and acute myeloid leukemia in congenital neutropenias. \nGranulocyte colony-stimulating factor (G-CSF) has had a major impact on the management of \"severe chronic neutropenia\" (SCN), a collective term ... | [
{
"id": "PMID-11957196_T1",
"type": "Cancer",
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37,
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},
{
"id": "PMID-11957196_T2",
"type": "Gene_or_gene_product",
"text": [
"Granulocyte colony-stimulating... | [
{
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313,
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},
"arguments": [
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"role": "Cause",
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{
... | [
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{
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}
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76 | PMID-18565374 | [
{
"id": "PMID-18565374__text",
"type": "abstract",
"text": [
"Contemporary perspectives on vital pulp therapy: views from the endodontists and pediatric dentists.\nThe purpose of this study was to determine the level of agreement between pediatric dentists and endodontists at a pulp therapy sympos... | [
{
"id": "PMID-18565374_T1",
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35,
39
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},
{
"id": "PMID-18565374_T2",
"type": "Tissue",
"text": [
"pulp"
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216,
220... | [
{
"id": "PMID-18565374_E1",
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"text": [
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40,
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},
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"role": "Theme",
"ref_id": "PMID-18565374_T1"
}
]
},
{
... | [] | [] |
77 | PMID-18469146 | [
{
"id": "PMID-18469146__text",
"type": "abstract",
"text": [
"Acute ethanol exposure disrupts VEGF receptor cell signaling in endothelial cells.\nPhysiological angiogenesis is regulated by various factors, including signaling through vascular endothelial growth factor (VEGF) receptors. We previous... | [
{
"id": "PMID-18469146_T1",
"type": "Simple_chemical",
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],
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6,
13
]
],
"normalized": []
},
{
"id": "PMID-18469146_T2",
"type": "Gene_or_gene_product",
"text": [
"VEGF receptor"
],
"offsets": ... | [
{
"id": "PMID-18469146_E1",
"type": "Planned_process",
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"exposure"
],
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[
14,
22
]
]
},
"arguments": [
{
"role": "Instrument",
"ref_id": "PMID-18469146_T1"
}
]
}... | [] | [] |
78 | PMID-8874381 | [
{
"id": "PMID-8874381__text",
"type": "abstract",
"text": [
"Gene transfer of naked DNA encoding for three isoforms of vascular endothelial growth factor stimulates collateral development in vivo.\nVascular endothelial growth factor (VEGF) is a naturally secreted endothelial cell-specific mitogen.... | [
{
"id": "PMID-8874381_T1",
"type": "Cellular_component",
"text": [
"DNA"
],
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23,
26
]
],
"normalized": []
},
{
"id": "PMID-8874381_T2",
"type": "Gene_or_gene_product",
"text": [
"vascular endothelial growth factor"
... | [
{
"id": "PMID-8874381_E1",
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93,
103
]
]
},
"arguments": [
{
"role": "Theme",
"ref_id": "PMID-8874381_E2"
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{
... | [
{
"id": "PMID-8874381_1",
"entity_ids": [
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"PMID-8874381_T5"
]
}
] | [] |
79 | PMID-12727857 | [
{
"id": "PMID-12727857__text",
"type": "abstract",
"text": [
"Tumor angiogenesis modulates leukocyte-vessel wall interactions in vivo by reducing endothelial adhesion molecule expression.\nThe expression of endothelial cell (EC) adhesion molecules involved in leukocyte-vessel wall interactions is ... | [
{
"id": "PMID-12727857_T1",
"type": "Cancer",
"text": [
"Tumor"
],
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[
0,
5
]
],
"normalized": []
},
{
"id": "PMID-12727857_T2",
"type": "Cell",
"text": [
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],
"offsets": [
[
29,
38... | [
{
"id": "PMID-12727857_E1",
"type": "Blood_vessel_development",
"trigger": {
"text": [
"angiogenesis"
],
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[
6,
18
]
]
},
"arguments": [
{
"role": "AtLoc",
"ref_id": "PMID-12727857_T1"
}
... | [] | [] |
80 | PMID-6325250 | [
{
"id": "PMID-6325250__text",
"type": "abstract",
"text": [
"Molecular events leading to enhanced glucose transport in Rous sarcoma virus-transformed cells. \nTransformation by Rous sarcoma virus results in a dramatic increase in the rate at which the transformed cells transport glucose across the... | [
{
"id": "PMID-6325250_T1",
"type": "Simple_chemical",
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"glucose"
],
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37,
44
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],
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},
{
"id": "PMID-6325250_T2",
"type": "Organism",
"text": [
"Rous sarcoma virus"
],
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... | [
{
"id": "PMID-6325250_E1",
"type": "Positive_regulation",
"trigger": {
"text": [
"enhanced"
],
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[
28,
36
]
]
},
"arguments": [
{
"role": "Theme",
"ref_id": "PMID-6325250_E2"
}
]
},
... | [] | [] |
81 | PMID-19806573 | [
{
"id": "PMID-19806573__text",
"type": "abstract",
"text": [
"[Effect of osteopontin silencing by lentivirus-mediated delivery of siRNA on glioma cell invasion and apoptosis]. \nOBJECTIVE: To investigate the effect of osteopontin silencing on the invasion and apoptosis of U251 cells. METHODS: The ... | [
{
"id": "PMID-19806573_T1",
"type": "Gene_or_gene_product",
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],
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11,
22
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],
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},
{
"id": "PMID-19806573_T2",
"type": "Organism",
"text": [
"lentivirus"
],
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... | [
{
"id": "PMID-19806573_E1",
"type": "Regulation",
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"text": [
"Effect"
],
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[
1,
7
]
]
},
"arguments": [
{
"role": "Cause",
"ref_id": "PMID-19806573_E3"
},
{
"role"... | [] | [] |
82 | PMID-22172720 | [
{
"id": "PMID-22172720__text",
"type": "abstract",
"text": [
"beta-catenin signaling controls metastasis in Braf-activated Pten-deficient melanomas. \nMalignant melanoma is characterized by frequent metastasis, however, specific changes that regulate this process have not been clearly delineated. ... | [
{
"id": "PMID-22172720_T1",
"type": "Gene_or_gene_product",
"text": [
"beta-catenin"
],
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[
0,
12
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],
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},
{
"id": "PMID-22172720_T2",
"type": "Gene_or_gene_product",
"text": [
"Braf"
],
"offsets":... | [
{
"id": "PMID-22172720_E1",
"type": "Pathway",
"trigger": {
"text": [
"signaling"
],
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[
13,
22
]
]
},
"arguments": [
{
"role": "Participant",
"ref_id": "PMID-22172720_T1"
}
]
},
{
... | [
{
"id": "PMID-22172720_1",
"entity_ids": [
"PMID-22172720_T21",
"PMID-22172720_T22"
]
}
] | [] |
83 | PMID-21506108 | [
{
"id": "PMID-21506108__text",
"type": "abstract",
"text": [
"Induction of Id-1 by FGF-2 involves activity of EGR-1 and sensitizes neuroblastoma cells to cell death. \nInhibitor of differentiation-1 (Id-1) is a member of helix-loop-helix (HLH) family of proteins that regulate gene transcription th... | [
{
"id": "PMID-21506108_T1",
"type": "Gene_or_gene_product",
"text": [
"Id-1"
],
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[
13,
17
]
],
"normalized": []
},
{
"id": "PMID-21506108_T2",
"type": "Gene_or_gene_product",
"text": [
"FGF-2"
],
"offsets": [
... | [
{
"id": "PMID-21506108_E1",
"type": "Positive_regulation",
"trigger": {
"text": [
"Induction"
],
"offsets": [
[
0,
9
]
]
},
"arguments": [
{
"role": "Cause",
"ref_id": "PMID-21506108_T2"
},
{
... | [
{
"id": "PMID-21506108_1",
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"PMID-21506108_T6",
"PMID-21506108_T7"
]
},
{
"id": "PMID-21506108_2",
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"PMID-21506108_T16"
]
},
{
"id": "PMID-21506108_3",
"entity_ids": [
"PMID-21506108_T17",
... | [] |
84 | PMID-10978248 | [
{
"id": "PMID-10978248__text",
"type": "abstract",
"text": [
"Vasodilator-stimulated phosphoprotein is involved in stress-fiber and membrane ruffle formation in endothelial cells.\nVasodilator-stimulated phosphoprotein (VASP) is highly expressed in vascular endothelial cells, where it has been imp... | [
{
"id": "PMID-10978248_T1",
"type": "Gene_or_gene_product",
"text": [
"Vasodilator-stimulated phosphoprotein"
],
"offsets": [
[
0,
37
]
],
"normalized": []
},
{
"id": "PMID-10978248_T2",
"type": "Cellular_component",
"text": [
"stre... | [
{
"id": "PMID-10978248_E1",
"type": "Regulation",
"trigger": {
"text": [
"involved"
],
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[
41,
49
]
]
},
"arguments": [
{
"role": "Cause",
"ref_id": "PMID-10978248_T1"
},
{
"r... | [
{
"id": "PMID-10978248_1",
"entity_ids": [
"PMID-10978248_T5",
"PMID-10978248_T6"
]
}
] | [] |
85 | PMID-15623651 | [
{
"id": "PMID-15623651__text",
"type": "abstract",
"text": [
"2-methoxyestradiol inhibits hypoxia-inducible factor 1alpha, tumor growth, and angiogenesis and augments paclitaxel efficacy in head and neck squamous cell carcinoma.\nPURPOSE: Head and neck squamous cell carcinomas have been reported t... | [
{
"id": "PMID-15623651_T1",
"type": "Simple_chemical",
"text": [
"2-methoxyestradiol"
],
"offsets": [
[
0,
18
]
],
"normalized": []
},
{
"id": "PMID-15623651_T2",
"type": "Gene_or_gene_product",
"text": [
"hypoxia-inducible factor 1... | [
{
"id": "PMID-15623651_E1",
"type": "Negative_regulation",
"trigger": {
"text": [
"inhibits"
],
"offsets": [
[
19,
27
]
]
},
"arguments": [
{
"role": "Cause",
"ref_id": "PMID-15623651_T1"
},
{
... | [
{
"id": "PMID-15623651_1",
"entity_ids": [
"PMID-15623651_T9",
"PMID-15623651_T10"
]
}
] | [] |
86 | PMID-19292679 | [
{
"id": "PMID-19292679__text",
"type": "abstract",
"text": [
"The effect of perfluorocarbon-based artificial oxygen carriers on tissue-engineered trachea.\nThe biological effect of the perfluorocarbon-based artificial oxygen carrier (Oxygent) was investigated in tissue-engineered trachea (TET) con... | [
{
"id": "PMID-19292679_T1",
"type": "Simple_chemical",
"text": [
"perfluorocarbon"
],
"offsets": [
[
14,
29
]
],
"normalized": []
},
{
"id": "PMID-19292679_T2",
"type": "Simple_chemical",
"text": [
"oxygen"
],
"offsets": [
... | [
{
"id": "PMID-19292679_E1",
"type": "Regulation",
"trigger": {
"text": [
"effect"
],
"offsets": [
[
4,
10
]
]
},
"arguments": [
{
"role": "Theme",
"ref_id": "PMID-19292679_T3"
}
]
},
{
"id... | [
{
"id": "PMID-19292679_1",
"entity_ids": [
"PMID-19292679_T7",
"PMID-19292679_T8"
]
}
] | [] |
87 | PMID-1553573 | [
{
"id": "PMID-1553573__text",
"type": "abstract",
"text": [
"Granulocyte-macrophage colony-stimulating factor and interleukin-3 enhance the incorporation of cytosine arabinoside into the DNA of leukemic blasts and the cytotoxic effect on clonogenic cells from patients with acute myeloid leukemia. ... | [
{
"id": "PMID-1553573_T1",
"type": "Gene_or_gene_product",
"text": [
"Granulocyte-macrophage colony-stimulating factor"
],
"offsets": [
[
0,
48
]
],
"normalized": []
},
{
"id": "PMID-1553573_T2",
"type": "Gene_or_gene_product",
"text": [
... | [
{
"id": "PMID-1553573_E1",
"type": "Positive_regulation",
"trigger": {
"text": [
"enhance"
],
"offsets": [
[
67,
74
]
]
},
"arguments": [
{
"role": "Theme",
"ref_id": "PMID-1553573_E3"
},
{
... | [
{
"id": "PMID-1553573_1",
"entity_ids": [
"PMID-1553573_T9",
"PMID-1553573_T10"
]
},
{
"id": "PMID-1553573_2",
"entity_ids": [
"PMID-1553573_T11",
"PMID-1553573_T12"
]
},
{
"id": "PMID-1553573_3",
"entity_ids": [
"PMID-1553573_T15",
"PMID-1... | [] |
88 | PMID-11425277 | [
{
"id": "PMID-11425277__text",
"type": "abstract",
"text": [
"Current prospects for controlling cancer growth with non-cytotoxic agents--nutrients, phytochemicals, herbal extracts, and available drugs.\nIn animal or cell culture studies, the growth and spread of cancer can be slowed by many nutrie... | [
{
"id": "PMID-11425277_T1",
"type": "Cancer",
"text": [
"cancer"
],
"offsets": [
[
34,
40
]
],
"normalized": []
},
{
"id": "PMID-11425277_T2",
"type": "Cell",
"text": [
"cell"
],
"offsets": [
[
153,
157... | [
{
"id": "PMID-11425277_E1",
"type": "Regulation",
"trigger": {
"text": [
"controlling"
],
"offsets": [
[
22,
33
]
]
},
"arguments": [
{
"role": "Theme",
"ref_id": "PMID-11425277_E2"
}
]
},
{
... | [] | [] |
89 | PMID-11836604 | [
{
"id": "PMID-11836604__text",
"type": "abstract",
"text": [
"Prognostic significance of heat shock protein 27 (HSP27) in patients with oral squamous cell carcinoma. \nHeat shock proteins (HSPs) have been defined as proteins induced by heat shock and other environmental and pathophysiologic stress... | [
{
"id": "PMID-11836604_T1",
"type": "Gene_or_gene_product",
"text": [
"heat shock protein 27"
],
"offsets": [
[
27,
48
]
],
"normalized": []
},
{
"id": "PMID-11836604_T2",
"type": "Gene_or_gene_product",
"text": [
"HSP27"
],
... | [
{
"id": "PMID-11836604_E1",
"type": "Regulation",
"trigger": {
"text": [
"play important roles"
],
"offsets": [
[
487,
507
]
]
},
"arguments": [
{
"role": "Cause",
"ref_id": "PMID-11836604_T10"
},
... | [
{
"id": "PMID-11836604_1",
"entity_ids": [
"PMID-11836604_T1",
"PMID-11836604_T2"
]
},
{
"id": "PMID-11836604_2",
"entity_ids": [
"PMID-11836604_T5",
"PMID-11836604_T6"
]
},
{
"id": "PMID-11836604_3",
"entity_ids": [
"PMID-11836604_T7",
"PM... | [] |
90 | PMID-15355640 | [
{
"id": "PMID-15355640__text",
"type": "abstract",
"text": [
"[Altered expression of PTEN gene and LOH of its epigenetic microsatellite in gastric carcinoma]. \nOBJECTIVE: To investigate the expression of PTEN and loss of heterozygosity (LOH) of its epigenetic microsatellite in gastric carcinoma a... | [
{
"id": "PMID-15355640_T1",
"type": "Gene_or_gene_product",
"text": [
"PTEN"
],
"offsets": [
[
23,
27
]
],
"normalized": []
},
{
"id": "PMID-15355640_T2",
"type": "Cancer",
"text": [
"gastric carcinoma"
],
"offsets": [
... | [
{
"id": "PMID-15355640_E1",
"type": "Regulation",
"trigger": {
"text": [
"Altered"
],
"offsets": [
[
1,
8
]
]
},
"arguments": [
{
"role": "Theme",
"ref_id": "PMID-15355640_E2"
}
]
},
{
"id... | [] | [] |
91 | PMID-10816661 | [
{
"id": "PMID-10816661__text",
"type": "abstract",
"text": [
"Alpha-melanocyte-stimulating hormone modulates activation of NF-kappa B and AP-1 and secretion of interleukin-8 in human dermal fibroblasts.\nAlpha-melanocyte-stimulating hormone (alpha-MSH) has evolved as a mediator of diverse biologic... | [
{
"id": "PMID-10816661_T1",
"type": "Gene_or_gene_product",
"text": [
"Alpha-melanocyte-stimulating hormone"
],
"offsets": [
[
0,
36
]
],
"normalized": []
},
{
"id": "PMID-10816661_T2",
"type": "Gene_or_gene_product",
"text": [
"NF-... | [
{
"id": "PMID-10816661_E1",
"type": "Regulation",
"trigger": {
"text": [
"modulates"
],
"offsets": [
[
37,
46
]
]
},
"arguments": [
{
"role": "Cause",
"ref_id": "PMID-10816661_T1"
},
{
"... | [
{
"id": "PMID-10816661_1",
"entity_ids": [
"PMID-10816661_T8",
"PMID-10816661_T7"
]
},
{
"id": "PMID-10816661_2",
"entity_ids": [
"PMID-10816661_T19",
"PMID-10816661_T20"
]
},
{
"id": "PMID-10816661_3",
"entity_ids": [
"PMID-10816661_T28",
... | [] |
92 | PMID-11381168 | [
{
"id": "PMID-11381168__text",
"type": "abstract",
"text": [
"Effects of morphological patterning on endothelial cell migration.\nThe migration of vascular endothelial cells (ECs) plays an important role in vascular remodeling. Here we studied the effects of cell morphology on the migration of bov... | [
{
"id": "PMID-11381168_T1",
"type": "Cell",
"text": [
"endothelial cell"
],
"offsets": [
[
39,
55
]
],
"normalized": []
},
{
"id": "PMID-11381168_T2",
"type": "Cell",
"text": [
"vascular endothelial cells"
],
"offsets": [
... | [
{
"id": "PMID-11381168_E1",
"type": "Regulation",
"trigger": {
"text": [
"Effects"
],
"offsets": [
[
0,
7
]
]
},
"arguments": [
{
"role": "Theme",
"ref_id": "PMID-11381168_E2"
}
]
},
{
"id... | [
{
"id": "PMID-11381168_1",
"entity_ids": [
"PMID-11381168_T2",
"PMID-11381168_T3"
]
}
] | [] |
93 | PMID-11107120 | [
{
"id": "PMID-11107120__text",
"type": "abstract",
"text": [
"p75 mediated apoptosis in neuroblastoma cells is inhibited by expression of TrkA. \nBACKGROUND: Neurotrophins mediate their effects by binding to members of the Trk family of receptor tyrosine kinases and to the low-affinity nerve growt... | [
{
"id": "PMID-11107120_T1",
"type": "Gene_or_gene_product",
"text": [
"p75"
],
"offsets": [
[
0,
3
]
],
"normalized": []
},
{
"id": "PMID-11107120_T2",
"type": "Cell",
"text": [
"neuroblastoma cells"
],
"offsets": [
[
... | [
{
"id": "PMID-11107120_E1",
"type": "Positive_regulation",
"trigger": {
"text": [
"mediated"
],
"offsets": [
[
4,
12
]
]
},
"arguments": [
{
"role": "Cause",
"ref_id": "PMID-11107120_T1"
},
{
... | [
{
"id": "PMID-11107120_1",
"entity_ids": [
"PMID-11107120_T7",
"PMID-11107120_T8"
]
},
{
"id": "PMID-11107120_2",
"entity_ids": [
"PMID-11107120_T12",
"PMID-11107120_T13"
]
}
] | [] |
94 | PMID-12920663 | [
{
"id": "PMID-12920663__text",
"type": "abstract",
"text": [
"Proliferative diabetic retinopathy is associated with a low level of the natural ocular anti-angiogenic agent pigment epithelium-derived factor (PEDF) in aqueous humor. a pilot study.\nRetinopathy is the most common microvascular diabet... | [
{
"id": "PMID-12920663_T1",
"type": "Organ",
"text": [
"ocular"
],
"offsets": [
[
81,
87
]
],
"normalized": []
},
{
"id": "PMID-12920663_T2",
"type": "Gene_or_gene_product",
"text": [
"pigment epithelium-derived factor"
],
"... | [
{
"id": "PMID-12920663_E1",
"type": "Blood_vessel_development",
"trigger": {
"text": [
"angiogenic"
],
"offsets": [
[
93,
103
]
]
},
"arguments": [
{
"role": "AtLoc",
"ref_id": "PMID-12920663_T1"
}
... | [
{
"id": "PMID-12920663_1",
"entity_ids": [
"PMID-12920663_T2",
"PMID-12920663_T3"
]
},
{
"id": "PMID-12920663_2",
"entity_ids": [
"PMID-12920663_T11",
"PMID-12920663_T12"
]
},
{
"id": "PMID-12920663_3",
"entity_ids": [
"PMID-12920663_T13",
... | [] |
95 | PMID-11255762 | [
{
"id": "PMID-11255762__text",
"type": "abstract",
"text": [
"[Study of fungus polysaccharides compounds (FPC) in inducing the apoptosis of liver cancer cell Bel-7402]. \nTo observe the influence of fungus polysaccharides compounds (FPC) in inducing human liver cancer cell Bel-7402 apoptosis in ce... | [
{
"id": "PMID-11255762_T1",
"type": "Simple_chemical",
"text": [
"fungus polysaccharides compounds"
],
"offsets": [
[
10,
42
]
],
"normalized": []
},
{
"id": "PMID-11255762_T2",
"type": "Simple_chemical",
"text": [
"FPC"
],
... | [
{
"id": "PMID-11255762_E1",
"type": "Positive_regulation",
"trigger": {
"text": [
"inducing"
],
"offsets": [
[
52,
60
]
]
},
"arguments": [
{
"role": "Cause",
"ref_id": "PMID-11255762_T1"
},
{
... | [
{
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},
{
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"PMID-11255762_T5"
]
}
] | [] |
96 | PMID-18319331 | [
{
"id": "PMID-18319331__text",
"type": "abstract",
"text": [
"Mitogen-activated protein kinase kinase signaling promotes growth and vascularization of fibrosarcoma.\nWe hypothesized that signaling through multiple mitogen-activated protein kinase (MAPK) kinase (MKK) pathways is essential for the g... | [
{
"id": "PMID-18319331_T1",
"type": "Gene_or_gene_product",
"text": [
"Mitogen-activated protein kinase kinase"
],
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[
0,
39
]
],
"normalized": []
},
{
"id": "PMID-18319331_T2",
"type": "Cancer",
"text": [
"fibrosarcoma"
... | [
{
"id": "PMID-18319331_E1",
"type": "Pathway",
"trigger": {
"text": [
"signaling"
],
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[
40,
49
]
]
},
"arguments": [
{
"role": "Participant",
"ref_id": "PMID-18319331_T1"
}
]
},
{
... | [
{
"id": "PMID-18319331_1",
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},
{
"id": "PMID-18319331_2",
"entity_ids": [
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"PMID-18319331_T13"
]
}
] | [] |
97 | PMID-19080335 | [
{
"id": "PMID-19080335__text",
"type": "abstract",
"text": [
"Effect of transplanted mesenchymal stem cells from rats of different ages on the improvement of heart function after acute myocardial infarction.\nBACKGROUND: Mesenchymal stem cells (MSCs) transplantation is of therapeutic potential aft... | [
{
"id": "PMID-19080335_T1",
"type": "Cell",
"text": [
"mesenchymal stem cells"
],
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[
23,
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]
],
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},
{
"id": "PMID-19080335_T2",
"type": "Organism",
"text": [
"rats"
],
"offsets": [
[
... | [
{
"id": "PMID-19080335_E1",
"type": "Regulation",
"trigger": {
"text": [
"Effect"
],
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[
0,
6
]
]
},
"arguments": [
{
"role": "Theme",
"ref_id": "PMID-19080335_T1"
}
]
},
{
"id"... | [
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]
},
{
"id": "PMID-19080335_2",
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"PMID-19080335_T25",
"PMID-19080335_T26"
]
}
] | [] |
98 | PMID-15574223 | [
{
"id": "PMID-15574223__text",
"type": "abstract",
"text": [
"Silencing of monocarboxylate transporters via small interfering ribonucleic acid inhibits glycolysis and induces cell death in malignant glioma: an in vitro study. \nOBJECTIVE: Dependence on glycolysis is a hallmark of malignant tumors.... | [
{
"id": "PMID-15574223_T1",
"type": "Gene_or_gene_product",
"text": [
"monocarboxylate transporters"
],
"offsets": [
[
13,
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]
],
"normalized": []
},
{
"id": "PMID-15574223_T2",
"type": "Cell",
"text": [
"cell"
],
"offsets"... | [
{
"id": "PMID-15574223_E1",
"type": "Negative_regulation",
"trigger": {
"text": [
"Silencing"
],
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[
0,
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]
]
},
"arguments": [
{
"role": "Theme",
"ref_id": "PMID-15574223_T1"
}
]
},
... | [
{
"id": "PMID-15574223_1",
"entity_ids": [
"PMID-15574223_T8",
"PMID-15574223_T9"
]
}
] | [] |
99 | PMID-19389366 | [
{
"id": "PMID-19389366__text",
"type": "abstract",
"text": [
"Bmi-1 over-expression in neural stem/progenitor cells increases proliferation and neurogenesis in culture but has little effect on these functions in vivo. \nThe polycomb gene Bmi-1 is required for the self-renewal of stem cells from di... | [
{
"id": "PMID-19389366_T1",
"type": "Gene_or_gene_product",
"text": [
"Bmi-1"
],
"offsets": [
[
0,
5
]
],
"normalized": []
},
{
"id": "PMID-19389366_T2",
"type": "Cell",
"text": [
"neural stem/progenitor cells"
],
"offsets":... | [
{
"id": "PMID-19389366_E1",
"type": "Gene_expression",
"trigger": {
"text": [
"over-expression"
],
"offsets": [
[
6,
21
]
]
},
"arguments": [
{
"role": "Theme",
"ref_id": "PMID-19389366_T1"
}
]
... | [
{
"id": "PMID-19389366_1",
"entity_ids": [
"PMID-19389366_T6",
"PMID-19389366_T7"
]
},
{
"id": "PMID-19389366_2",
"entity_ids": [
"PMID-19389366_T31",
"PMID-19389366_T32"
]
},
{
"id": "PMID-19389366_3",
"entity_ids": [
"PMID-19389366_T33",
... | [] |
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