import pytest
from sanic import Sanic
from sanic_openapi import swagger_blueprint


@pytest.fixture()
def app():
    app = Sanic('test')
    app.blueprint(swagger_blueprint)
    return app

import pytest
from sanic import Sanic

import sanic_openapi


@pytest.fixture()
def app():
    app = Sanic("test")
    app.blueprint(sanic_openapi.swagger_blueprint)
    yield app

    # Clean up
    sanic_openapi.swagger.definitions = {}
    sanic_openapi.swagger._spec = {}

Add clean up in app fixture