old_contents: import os
  from indra.preassembler.hierarchy_manager import HierarchyManager
  
  # Make a TRIPS ontology
  _fname = os.path.join(os.path.dirname(__file__), 'trips_ontology.rdf')
  trips_ontology = HierarchyManager(_fname, uri_as_name=False)
  trips_ontology.relations_prefix = 'http://trips.ihmc.us/relations/'
  trips_ontology.initialize()
  
  def trips_isa(concept1, concept2):
      # Preprocess to make this more general
      concept1 = concept1.lower().replace('ont::', '')
      concept2 = concept2.lower().replace('ont::', '')
      if concept1 == concept2:
          return True
      isa = trips_ontology.isa('http://trips.ihmc.us/concepts/', concept1,
                               'http://trips.ihmc.us/concepts/', concept2)
      return isa
  
new_contents: import os
  from indra.preassembler.hierarchy_manager import HierarchyManager
  
  # Make a TRIPS ontology
  _fname = os.path.join(os.path.dirname(__file__), 'trips_ontology.rdf')
  trips_ontology = HierarchyManager(_fname, uri_as_name=False, build_closure=True)
  trips_ontology.relations_prefix = 'http://trips.ihmc.us/relations/'
  trips_ontology.initialize()
  
  def trips_isa(concept1, concept2):
      # Preprocess to make this more general
      concept1 = concept1.lower().replace('ont::', '')
      concept2 = concept2.lower().replace('ont::', '')
      if concept1 == concept2:
          return True
      isa = trips_ontology.isa('http://trips.ihmc.us/concepts/', concept1,
                               'http://trips.ihmc.us/concepts/', concept2)
      return isa
  
subject: Build closure for TRIPS ontology