The identification of FH as a tumor suppressor was an unexpected finding and following the identification of subunits of succinate dehydrogenase in 2000 and 2001 , was only the second description of the involvement of an enzyme of intermediary metabolism in tumorigenesis .
O O O B-GeneOrGeneProduct O O B-DiseaseOrPhenotypicFeature O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O B-DiseaseOrPhenotypicFeature O