Thus , our study demonstrates for the first time , a novel OPRM1-mediated mechanism for L-asparaginase resistance in ALL , and identifies OPRM1 as a functional biomarker for defining high-risk subpopulations and for the detection of evolving resistant clones .
O O O O O O O O O O O O B-GeneOrGeneProduct O O B-ChemicalEntity O O B-DiseaseOrPhenotypicFeature O O O B-GeneOrGeneProduct O O O O O O O O O O O O O O O O O