RESULTS : A single heterozygous missense mutation , substitution of a cytosine residue with thymidine in exon 2 of MSH5 , was found in two Caucasian women in whom POF developed at 18 and 36 years of age .
O O O O O O O O O O O B-SequenceVariant I-SequenceVariant I-SequenceVariant I-SequenceVariant O O O O B-GeneOrGeneProduct O O O O O O B-OrganismTaxon O O B-DiseaseOrPhenotypicFeature O O O O O O O O O