Overall , eight families with six mutations in ARX were identified ( 1.31 % ) : five duplication mutations in pA2 ( 0.82 % ) with three new clinical reports of families with the dup24bp and two duplications larger than the dup24bp mutation discovered ( dup27bp , dup33bp ) ; and three point mutations ( 0.6 % ) , including one novel mutation in the homeodomain ( c.1074G > T ) .
O O O O O O O O B-GeneOrGeneProduct O O O O O O O O O O O O O O O O O O O O O O O O O B-SequenceVariant O O O O O O B-SequenceVariant O O O B-SequenceVariant O B-SequenceVariant O O O O O O O O O O O O O O O O O O O B-SequenceVariant I-SequenceVariant I-SequenceVariant O O