Notably , Myc-overexpressing B cells maintained elevated BCR signaling despite treatment with ibrutinib , a Bruton 's tyrosine kinase inhibitor .
O O B-GeneOrGeneProduct O O O O B-GeneOrGeneProduct O O O O B-ChemicalEntity O O B-GeneOrGeneProduct I-GeneOrGeneProduct I-GeneOrGeneProduct I-GeneOrGeneProduct O O