Mutations leading to abrogation of matriptase-2 proteolytic activity in humans are associated with an iron-refractory iron deficiency anemia ( IRIDA ) due to elevated hepcidin levels .
O O O O O B-GeneOrGeneProduct O O O B-OrganismTaxon O O O O B-DiseaseOrPhenotypicFeature I-DiseaseOrPhenotypicFeature I-DiseaseOrPhenotypicFeature I-DiseaseOrPhenotypicFeature O B-DiseaseOrPhenotypicFeature O O O O B-GeneOrGeneProduct O O