In addition , from 10 to 50 weeks of age , stage-specific expression profiling of miRNA in KC mice revealed downregulation of miR-216 , miR-217 , miR-100 , miR-345 , miR-141 , miR-483-3p , miR-26b , miR-150 , miR-195 , Let-7b and Let-96 and upregulation of miR-21 , miR-205 , miR-146b , miR-34c , miR-1273 , miR-223 and miR-195 compared to control mice .
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