The doses calculated to cause 50 % reversal of hyperalgesia ( ED50 ) were 7.54 ( 1.81 ) and 4.83 ( 1.54 ) in the carrageenan model and 44.18 ( 1.37 ) and 9.14 ( 1.24 ) in the STZ-induced neuropathy model for CNSB002 and morphine , respectively ( mg/kg ; mean , SEM ) .
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