In TIPE2 over-expression cells , caspase-3 , caspase-9 , and Bax were significantly up-regulated while Bcl-2 was down-regulated .
O B-GeneOrGeneProduct O O O B-GeneOrGeneProduct O B-GeneOrGeneProduct O O B-GeneOrGeneProduct O O O O B-GeneOrGeneProduct O O O