On the 10th day of paroxetine and alprazolam treatment , the patient exhibited marked psychomotor retardation , disorientation , and severe muscle rigidity with tremors .
O O O O O B-ChemicalEntity O B-ChemicalEntity O O O B-OrganismTaxon O O B-DiseaseOrPhenotypicFeature I-DiseaseOrPhenotypicFeature O O O O O B-DiseaseOrPhenotypicFeature I-DiseaseOrPhenotypicFeature O B-DiseaseOrPhenotypicFeature O