We found that the E333D mutation neither significantly affected the affinity of the receptor for T3 nor modified heterodimer formation with retinoid X receptor ( RXR ) when bound to DNA .
O O O O B-SequenceVariant O O O O O O O O O O B-ChemicalEntity O O O O O B-GeneOrGeneProduct I-GeneOrGeneProduct I-GeneOrGeneProduct O B-GeneOrGeneProduct O O O O O O