A total of 10 novel variants was recognized , among them four variants in the adjacent 5'-region of the GJB2 coding exon 2 ( g.3318-6T > A , g.3318-15C > T , g.3318-34C > T , g.3318-35T > G ) , a 6 base-pair deletion ( g.3455_3460del [ p.Asp46_Gln48delinsGlu ] ) , a variant leading to a stop codon ( g.3512C > A [ p.Tyr65X ] ) , synonymous variants ( g.3395C > T [ p.Thr26 ] , g.3503C > T [ p.Asn62 ] , g.3627A > C [ p.Arg104 ] ) , and one non-synonymous variant ( g.3816C > A [ p.Val167Met ] ) .
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