In addition , emodin altered FASN-involved signaling pathways , including phosphatidylinositol 3-kinase/Akt and mitogen-activated protein kinases/extracellular signal-regulated kinases 1/2 .
O O O B-ChemicalEntity O B-GeneOrGeneProduct O O O O B-GeneOrGeneProduct I-GeneOrGeneProduct O B-GeneOrGeneProduct I-GeneOrGeneProduct I-GeneOrGeneProduct I-GeneOrGeneProduct I-GeneOrGeneProduct I-GeneOrGeneProduct O