Seven novel single-nucleotide polymorphisms ( SNPs ) were also found , of which a change of leucine 269 to phenylalanine ( Leu269Phe ) was found in 12 of 18 patients with the Arg555Trp mutation .
O O O O O O O O O O O O O O O O B-SequenceVariant I-SequenceVariant I-SequenceVariant I-SequenceVariant O B-SequenceVariant O O O O O O O B-OrganismTaxon O O B-SequenceVariant O O