We have investigated three other single-nucleotide polymorphisms in the hPER2 gene , one downstream of the transcription start site ( C-1228T ) , one in exon 2 in the 5'-untranslated region ( 5'-UTR ) ( C111G ) , and one missense mutation ( G3853A ) causing a glycine to glutamine substitution in the predicted protein .
O O O O O O O O O B-GeneOrGeneProduct O O O O O O O O O O B-SequenceVariant O O O O O O O O O O O O O O B-SequenceVariant O O O O O O O B-SequenceVariant O O O B-SequenceVariant I-SequenceVariant I-SequenceVariant O O O O O O