Protein instability of L1503R may be responsible for its intracellular retention and perhaps the larger VWF multimers , containing more mutant VWF subunits , are likely to be mal-processed and retained within the cell .
O O O B-SequenceVariant O O O O O O O O O O O B-GeneOrGeneProduct O O O O O B-GeneOrGeneProduct O O O O O O O O O O O O O