Subsequent mutation analysis of PQBP1 , located within the delineated linkage interval in Xp11.23 , revealed a 2-bp deletion , c.461_462delAG , that cosegregated with the disease .
O O O O B-GeneOrGeneProduct O O O O O O O O O O O O O O O B-SequenceVariant O O O O O O O