Its +1858C > T ( R620W ) polymorphism has been shown to associate with a risk for multiple autoimmune diseases , including type 1 diabetes ( T1D ) and juvenile idiopathic arthritis ( JIA ) .
O B-SequenceVariant I-SequenceVariant I-SequenceVariant O B-SequenceVariant O O O O O O O O O O O O B-DiseaseOrPhenotypicFeature I-DiseaseOrPhenotypicFeature O O B-DiseaseOrPhenotypicFeature I-DiseaseOrPhenotypicFeature I-DiseaseOrPhenotypicFeature O B-DiseaseOrPhenotypicFeature O O B-DiseaseOrPhenotypicFeature I-DiseaseOrPhenotypicFeature I-DiseaseOrPhenotypicFeature O B-DiseaseOrPhenotypicFeature O O