We generated IFNAR1 subunit-deficient LEW.1WR1 rats using CRISPR-Cas9 ( clustered regularly interspaced short palindromic repeats-associated protein 9 ) genome editing and confirmed functional disruption of the Ifnar1 gene .
O O B-GeneOrGeneProduct O O B-OrganismTaxon O O O O O O O O O O O O O O O O O O O O B-GeneOrGeneProduct O O