In vitro hydrolysis of ED was done in aqueous buffers ( pH 1.2 , 7.4 , 9 ) and in 80 % ( v/v ) human plasma ( pH 7.4 ) .
O O O O B-ChemicalEntity O O O O O O O O O O O O O O O O O O O O B-OrganismTaxon O O O O O O