The most relevant adverse event was peripheral neuropathy , which occurred in 78 % of the patients ( grade II , 38 % ; grade III , 21 % ) and led to treatment discontinuation in 6 % .
O O O O O O B-DiseaseOrPhenotypicFeature I-DiseaseOrPhenotypicFeature O O O O O O O O B-OrganismTaxon O O O O O O O O O O O O O O O O O O O O O O