We suggest that trazodone ( 5 , 10 and 20 mg/kg ) , by blocking the 5-HT 2C receptors , releases the nigrostriatal DAergic neurons from tonic inhibition caused by 5-HT , and thereby potentiates dexamphetamine stereotypy and antagonizes haloperidol catalepsy .
O O O B-ChemicalEntity O O O O O O O O O O O O B-GeneOrGeneProduct I-GeneOrGeneProduct I-GeneOrGeneProduct O O O O O O O O O O O B-ChemicalEntity O O O O B-ChemicalEntity O O O B-ChemicalEntity B-DiseaseOrPhenotypicFeature O