Mechanistically , decreased Warburg effect as demonstrated by reduced glucose consumption and lactate secretion and reduced expression of MMP-9 , PLAU , and cathepsin B were found after LDHA knockdown or FX11 treatment in PC-3 and DU145 cells .
O O O O O O O O O B-ChemicalEntity O O B-ChemicalEntity O O O O O B-GeneOrGeneProduct O B-GeneOrGeneProduct O O B-GeneOrGeneProduct I-GeneOrGeneProduct O O O B-GeneOrGeneProduct O O B-ChemicalEntity O O B-CellLine O B-CellLine O O