These results support the conclusion that the 1858C/T allele is the major risk variant for type 1 diabetes in the PTPN22 locus , but they suggest that additional infrequent coding variants at PTPN22 may also contribute to type 1 diabetes risk .
O O O O O O O B-SequenceVariant O O O O O O O B-DiseaseOrPhenotypicFeature I-DiseaseOrPhenotypicFeature I-DiseaseOrPhenotypicFeature O O B-GeneOrGeneProduct O O O O O O O O O O O B-GeneOrGeneProduct O O O O B-DiseaseOrPhenotypicFeature I-DiseaseOrPhenotypicFeature I-DiseaseOrPhenotypicFeature O O