Overall , these findings indicate that VPA treatment results in oxidative stress , as measured by levels of 15-F ( 2t ) -IsoP , which precedes the onset of necrosis , steatosis , and elevated levels of serum alpha-GST .
O O O O O O B-ChemicalEntity O O O O O O O O O O O B-ChemicalEntity I-ChemicalEntity I-ChemicalEntity I-ChemicalEntity I-ChemicalEntity O O O O O O B-DiseaseOrPhenotypicFeature O B-DiseaseOrPhenotypicFeature O O O O O O B-GeneOrGeneProduct O