Recent studies have reported germline mutations in GATA4 gene in some types of congenital heart disease ( CHD ) .
O O O O O O O B-GeneOrGeneProduct O O O O O B-DiseaseOrPhenotypicFeature I-DiseaseOrPhenotypicFeature I-DiseaseOrPhenotypicFeature O B-DiseaseOrPhenotypicFeature O O