Furthermore , in vitro and in vivo investigations revealed a unique T cell population , IL-10-producing CD3+CD4+LAG-3+CD49b+CD25-Foxp3- Tr1 cells , that was significantly increased without altering the Foxp3+ regulatory T cell population .
O O O O O O O O O O O O O O O B-GeneOrGeneProduct I-GeneOrGeneProduct O O O O O O O O O O B-GeneOrGeneProduct O O O O O