Sequencing of the GJB2 gene showed that the child was heterozygous for a novel nucleotide change , c.263C > T , in exon 2 , leading to a substitution of alanine for valine at position 88 ( p.Ala88Val ) .
O O O B-GeneOrGeneProduct O O O O O O O O O O O O O B-SequenceVariant I-SequenceVariant I-SequenceVariant O O O O O O O O O O B-SequenceVariant I-SequenceVariant I-SequenceVariant I-SequenceVariant I-SequenceVariant I-SequenceVariant O B-SequenceVariant O O