Our observation of frequent p14 gene abnormalities ( 90 % ) and inactivation ( 40-60 % ) was in striking contrast to the same pathological subtype of systemic lymphoma in which p14 gene abnormalities and inactivation were infrequent , suggesting a difference in carcinogenesis between PCNSL and systemic lymphoma .
O O O O B-GeneOrGeneProduct O O O O O O O O O O O O O O O O O O O O O O B-DiseaseOrPhenotypicFeature I-DiseaseOrPhenotypicFeature O O B-GeneOrGeneProduct O O O O O O O O O O O B-DiseaseOrPhenotypicFeature O B-DiseaseOrPhenotypicFeature O B-DiseaseOrPhenotypicFeature I-DiseaseOrPhenotypicFeature O