To determine whether there was a temporal relationship between VPA-associated oxidative stress and hepatotoxicity , adult male Sprague-Dawley rats were treated ip with VPA ( 500 mg/kg ) or 0.9 % saline ( vehicle ) once daily for 2 , 4 , 7 , 10 , or 14 days .
O O O O O O O O O B-ChemicalEntity O O O B-DiseaseOrPhenotypicFeature O O O O B-OrganismTaxon O O O O B-ChemicalEntity O O O O O O O O O O O O O O O O O O O O O O O O O O