Therefore , our results indicate that precancerous B cells have already acquired enhanced survival and growth capabilities before transformation , and that elevated MYC levels confer resistance to pharmacologic inhibitors of BCR signaling , which has significant implications for B-NHL treatment .
O O O O O O B-DiseaseOrPhenotypicFeature O O O O O O O O O O O O O O O O B-GeneOrGeneProduct O O O O O O O B-GeneOrGeneProduct O O O O O O O B-DiseaseOrPhenotypicFeature O O