Hsp90beta inhibition caused the destabilization of upstream mediators in various pathogenic signalling events , thereby effectively ameliorating this nephropathy owing to renal hypoxia and oxidative stress .
B-GeneOrGeneProduct O O O O O O O O O O O O O O O O O B-DiseaseOrPhenotypicFeature O O B-DiseaseOrPhenotypicFeature I-DiseaseOrPhenotypicFeature O O O O