Testosterone ( 1 mg.kg ( -1 ) .d ( -1 ) , sc ) , the androgen receptor antagonist flutamide ( 10 mg.kg ( -1 ) .d ( -1 ) , ip ) , the estrogen receptor antagonist tamoxifen ( 1 mg.kg ( -1 ) .d ( -1 ) , ip ) or the aromatase inhibitor letrozole ( 4 mg.kg ( -1 ) .d ( -1 ) , ip ) were administered for 6 d after the first injection of STZ .
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