A common missense variant in the gene encoding a component of the sulfonylurea receptor ( ABCC8 p.A1369S ) promotes closure of the target channel of sulfonylurea therapy and is associated with increased insulin secretion , thus mimicking the effects of sulfonylurea therapy .
O O O O O O O O O O O O B-GeneOrGeneProduct I-GeneOrGeneProduct O B-GeneOrGeneProduct B-SequenceVariant O O O O O O O O B-ChemicalEntity O O O O O O B-GeneOrGeneProduct O O O O O O O B-ChemicalEntity O O