b ( + ) IVSI-110 ) and that this genetic combination has been selected within the population of b ( 0 ) -thalassemia patients , due to functional association with high HbF .
O O O O O O O O O O O O O O O O O O B-DiseaseOrPhenotypicFeature I-DiseaseOrPhenotypicFeature I-DiseaseOrPhenotypicFeature I-DiseaseOrPhenotypicFeature I-DiseaseOrPhenotypicFeature B-OrganismTaxon O O O O O O O B-GeneOrGeneProduct O