In this study , we found that mice with a genetic deletion of VIPR2 , encoding the VPAC2 receptor , exhibited exacerbated ( MOG35-55 ) -induced EAE compared to wild type mice , characterized by enhanced clinical and histopathological features , increased proinflammatory cytokines ( TNF-alpha , IL-6 , IFN-gamma ( Th1 ) , and IL-17 ( Th17 ) ) and reduced anti-inflammatory cytokines ( IL-10 , TGFbeta , and IL-4 ( Th2 ) ) in the CNS and lymph nodes .
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