RESULTS : A heterozygous germline T to C transition in exon 10 of the TSHR gene ( c.1358T -- > C ) resulting in the substitution of methionine ( ATG ) by threonine ( ACG ) at codon 453 ( p.M453T ) was identified in the father and his two children .
O O O O O B-SequenceVariant I-SequenceVariant I-SequenceVariant O O O O O O B-GeneOrGeneProduct O O B-SequenceVariant I-SequenceVariant I-SequenceVariant I-SequenceVariant O O O O O O B-SequenceVariant I-SequenceVariant I-SequenceVariant I-SequenceVariant I-SequenceVariant I-SequenceVariant I-SequenceVariant I-SequenceVariant I-SequenceVariant I-SequenceVariant I-SequenceVariant I-SequenceVariant O B-SequenceVariant O O O O O O O O O O O