Our data show that in pre-malignant B cells , Myc overexpression is sufficient to activate BCR and PI3K/Akt signaling pathways and further enhances signaling following BCR ligation .
O O O O O O O O O B-GeneOrGeneProduct O O O O O B-GeneOrGeneProduct O B-GeneOrGeneProduct O O O O O O O B-GeneOrGeneProduct O O