An analysis of the multiple single-nucleotide polymorphisms in SP-A demonstrated that homozygosity for alleles encoding lysine ( in 1A1 ) rather than glutamine ( in 1A5 ) at amino acid 223 in the carbohydrate recognition domain was associated with an increased risk of meningococcal disease ( OR , 6.7 ; 95 % CI , 1.4-31.5 ) .
O O O O O O O O B-GeneOrGeneProduct O O O O O O B-SequenceVariant I-SequenceVariant I-SequenceVariant I-SequenceVariant I-SequenceVariant I-SequenceVariant I-SequenceVariant I-SequenceVariant I-SequenceVariant I-SequenceVariant I-SequenceVariant I-SequenceVariant I-SequenceVariant I-SequenceVariant I-SequenceVariant I-SequenceVariant O O B-ChemicalEntity O O O O O O O O O B-DiseaseOrPhenotypicFeature I-DiseaseOrPhenotypicFeature O O O O O O O O O O O O