Taking into account that the sarcolemmal integrity is stabilized by the dystrophin-glycoprotein complex ( DGC ) that connects actin and laminin in contractile machinery and extracellular matrix and by integrins , this study tests the hypothesis that isoproterenol affects sarcolemmal stability through changes in the DGC and integrins .
O O O O O O O O O O O I-GeneOrGeneProduct O O O O O O B-GeneOrGeneProduct O B-GeneOrGeneProduct O O O O O O O O O O O O O O O O B-ChemicalEntity O O O O O O O O O O O