Sequence analysis of the VWF gene from two unrelated type 2A VWD patients showed an identical , novel , heterozygous T -- > G transversion at nucleotide 4508 , resulting in the substitution of L1503R in the VWF A2 domain .
O O O O B-GeneOrGeneProduct O O O O B-DiseaseOrPhenotypicFeature I-DiseaseOrPhenotypicFeature I-DiseaseOrPhenotypicFeature B-OrganismTaxon O O O O O O O B-SequenceVariant I-SequenceVariant I-SequenceVariant I-SequenceVariant I-SequenceVariant I-SequenceVariant I-SequenceVariant I-SequenceVariant O O O O O O B-SequenceVariant O O B-GeneOrGeneProduct O O O