This heterozygous phenotype illustrates that subtle changes in receptor tyrosine kinase signalling can have significant effects , perhaps providing an explanation for the numerous changes seen in cancer .
O O O O O O O O B-GeneOrGeneProduct I-GeneOrGeneProduct I-GeneOrGeneProduct O O O O O O O O O O O O O O O O B-DiseaseOrPhenotypicFeature O