CONCLUSION : Mutations affecting the intracellular domain of the GHR can result in GH insensitivity and IGF deficiency , despite normal serum concentrations of GHBP .
O O O O O O O O O B-GeneOrGeneProduct O O O B-DiseaseOrPhenotypicFeature I-DiseaseOrPhenotypicFeature O B-DiseaseOrPhenotypicFeature I-DiseaseOrPhenotypicFeature O O O O O O B-GeneOrGeneProduct O