CONCLUSIONS : In this study population , combination therapies with VAL/HCTZ were associated with significantly greater BP reductions compared with either monotherapy , were well tolerated , and were associated with less hypokalemia than HCTZ alone .
O O O O O O O O O O I-ChemicalEntity O O O O O O O O O O O O O O O O O O O O O B-DiseaseOrPhenotypicFeature O B-ChemicalEntity O O