Furthermore , Kras ( G12D ) -induced immortalization can also be abrogated by Sag deletion via senescence induction , which is again rescued by simultaneous deletion of Cdkn2a .
O O B-GeneOrGeneProduct O B-SequenceVariant O O O O O O O O B-GeneOrGeneProduct O O O O O O O O O O O O O B-GeneOrGeneProduct O