More than 100 different heterozygous mutations in copper/zinc superoxide dismutase ( SOD1 ) have been found in patients with amyotrophic lateral sclerosis ( ALS ) , a fatal neurodegenerative disease .
O O O O O O O B-GeneOrGeneProduct I-GeneOrGeneProduct I-GeneOrGeneProduct O B-GeneOrGeneProduct O O O O O B-OrganismTaxon O B-DiseaseOrPhenotypicFeature I-DiseaseOrPhenotypicFeature I-DiseaseOrPhenotypicFeature O B-DiseaseOrPhenotypicFeature O O O O B-DiseaseOrPhenotypicFeature I-DiseaseOrPhenotypicFeature O