Molecular dynamic simulations of structural changes induced by L1503R indicated that the mean value of all-atom root-mean-squared-deviation was shifted from those with wild type or another mutation L1503Q that has been reported to be a group II mutation , which is susceptible to ADAMTS13 proteolysis .
O O O O O O O O B-SequenceVariant O O O O O O O O O O O O O O O O O O B-SequenceVariant O O O O O O O O O O O O O O O B-GeneOrGeneProduct O O