CRELD1 is likely to be an AVSD-susceptibility gene and CRELD1 mutations may increase the risk of developing a heart defect rather than being a direct causative mutation .
B-GeneOrGeneProduct O O O O O B-DiseaseOrPhenotypicFeature O O B-GeneOrGeneProduct O O O O O O O O B-DiseaseOrPhenotypicFeature I-DiseaseOrPhenotypicFeature O O O O O O O O