The same variants in the IRF6 gene that are associated with isolated orofacial clefts are also associated with human tooth agenesis ( rs861019 , P = 0.058 ; rs17015215-V274I , P = 0.0006 ; rs7802 , P = 0.004 ) .
O O O O O B-GeneOrGeneProduct O O O O O O B-DiseaseOrPhenotypicFeature I-DiseaseOrPhenotypicFeature O O O O B-OrganismTaxon B-DiseaseOrPhenotypicFeature I-DiseaseOrPhenotypicFeature O B-SequenceVariant O O O O O B-SequenceVariant O O O O O B-SequenceVariant O O O O O O