In conclusion , the increased or sustained expression of ENaC subunits combined with increased apical targeting in the DCT2 , connecting tubule , and collecting duct are likely to play a role in the sodium retention associated with PAN-induced nephrotic syndrome .
O O O O O O O O O B-GeneOrGeneProduct I-GeneOrGeneProduct O O O O O O O O O O O O O O O O O O O O O O O B-ChemicalEntity O O O B-ChemicalEntity B-DiseaseOrPhenotypicFeature I-DiseaseOrPhenotypicFeature O