There were 53 major hemorrhages , for an annual rate of 10.0 % , including 24 ( 45.3 % ) life-threatening and five ( 9.4 % ) fatal bleeds .
O O O O B-DiseaseOrPhenotypicFeature O O O O O O O O O O O O O O O O O O O O O O O B-DiseaseOrPhenotypicFeature O