A novel point mutation in helix 10 of the human glucocorticoid receptor causes generalized glucocorticoid resistance by disrupting the structure of the ligand-binding domain .
O O O O O O O O O B-OrganismTaxon B-GeneOrGeneProduct I-GeneOrGeneProduct O O B-DiseaseOrPhenotypicFeature I-DiseaseOrPhenotypicFeature O O O O O O O O O