The search for HbF-associated polymorphisms ( such as the XmnI , BCL11A and MYB polymorphisms ) has recently gained great attention , in order to stratify b-thalassemia patients with respect to expectancy of the first transfusion , need for annual intake of blood , response to HbF inducers ( the most studied of which is hydroxyurea ) .
O O O B-GeneOrGeneProduct O O O O O O O B-GeneOrGeneProduct O B-GeneOrGeneProduct O O O O O O O O O O O O B-DiseaseOrPhenotypicFeature B-OrganismTaxon O O O O O O O O O O O O O O O O O O B-GeneOrGeneProduct O O O O O O O O O O O