The most frequent allelic variant , CYP2F1 * 2A ( 25.6 % ) , harbors a combination of 9 mutations , including 2 missense mutations ( Asp218Asn and Gln266His ) and a 1-bp insertion ( c.14_15insC ) that creates a premature stop codon in exon 2 , probably leading to the synthesis of a severely truncated protein with no catalytic activity .
O O O O O O B-GeneOrGeneProduct O O O O O O O O O O O O O O O O O O O B-SequenceVariant O B-SequenceVariant O O O B-SequenceVariant I-SequenceVariant O B-SequenceVariant O O O O O O O O O O O O O O O O O O O O O O O O O O