The study investigates if alpha-lipoic acid is neuroprotective against chemotherapy induced neurotoxicity , if mitochondrial damage plays a critical role in toxic neurodegenerative cascade , and if neuroprotective effects of alpha-lipoic acid depend on mitochondria protection .
O O O O B-ChemicalEntity I-ChemicalEntity O O O O O B-DiseaseOrPhenotypicFeature O O B-DiseaseOrPhenotypicFeature I-DiseaseOrPhenotypicFeature O O O O O B-DiseaseOrPhenotypicFeature I-DiseaseOrPhenotypicFeature I-DiseaseOrPhenotypicFeature O O O O O O B-ChemicalEntity I-ChemicalEntity O O O O O