In the first stage , 23 patients who developed severe myelosuppression and 58 patients who did not develop any toxicity were examined for 170 single nucleotide polymorphisms ( SNPs ) in 14 genes involved in the metabolism and transport of irinotecan .
O O O O O O B-OrganismTaxon O O O B-DiseaseOrPhenotypicFeature O O B-OrganismTaxon O O O O O B-DiseaseOrPhenotypicFeature O O O O O O O O O O O O O O O O O O O O B-ChemicalEntity O