Taken together , our results suggest that cisplatin induces immune-suppressive tolerogenic DCs in TLR agonist-induced inflammatory conditions via abundant IL-10 production , thereby skewing Th cell differentiation towards Th2 and Tr1 cells .
O O O O O O O B-ChemicalEntity O O O O O B-ChemicalEntity I-ChemicalEntity B-DiseaseOrPhenotypicFeature O O O B-GeneOrGeneProduct O O O O O O O O O O O O O