Importantly , 35 % ( 6/17 ) are tandem mutations , including 4 UV signature CC to TT transitions possibly linked to modulated DNA repair caused by the immunosuppressive drug cyclosporin A ( CsA ) .
O O O O O O O O O O O O O O O B-SequenceVariant I-SequenceVariant I-SequenceVariant O O O O O O O O O O O O B-ChemicalEntity I-ChemicalEntity O B-ChemicalEntity O O