Here we investigated the role of Sag/Rbx2 E3 ligase in cellular senescence and immortalization of mouse embryonic fibroblasts ( MEFs ) and report that Sag is required for proper cell proliferation and Kras ( G12D ) -induced immortalization .
O O O O O O I-GeneOrGeneProduct B-GeneOrGeneProduct I-GeneOrGeneProduct O O O O O O B-OrganismTaxon O O O O O O O O B-GeneOrGeneProduct O O O O O O O B-GeneOrGeneProduct O B-SequenceVariant O O O O