Like human TRPV6 , the truncated human TRPV6 ( Delta695-725 ) , which lacks the C-terminal domain required for Ca ( 2+ ) -calmodulin binding , does not form constitutive active channels , whereas the human TRPV6 ( D542A ) , carrying a point mutation in the presumed pore region , does not function as a channel .
O B-OrganismTaxon B-GeneOrGeneProduct O O O B-OrganismTaxon B-GeneOrGeneProduct O B-SequenceVariant O O O O O O O O O B-ChemicalEntity I-ChemicalEntity I-ChemicalEntity I-ChemicalEntity O O O O O O O O O O O O B-OrganismTaxon B-GeneOrGeneProduct O B-SequenceVariant O O O O O O O O O O O O O O O O O O O