A LD ( 10 ) dose ( 8 mg doxorubicin/kg , ip ) administered on day 43 of the HFD feeding regimen led to higher cardiotoxicity , cardiac dysfunction , lipid peroxidation , and 80 % mortality in the obese ( OB ) rats in the absence of any significant renal or hepatic toxicity .
O O O O O O O O O B-ChemicalEntity O O O O O O O O O O O O O O O B-DiseaseOrPhenotypicFeature O B-DiseaseOrPhenotypicFeature I-DiseaseOrPhenotypicFeature O B-ChemicalEntity O O O O O O O O B-DiseaseOrPhenotypicFeature O B-DiseaseOrPhenotypicFeature O B-OrganismTaxon O O O O O O B-DiseaseOrPhenotypicFeature I-DiseaseOrPhenotypicFeature I-DiseaseOrPhenotypicFeature I-DiseaseOrPhenotypicFeature O