RESULTS : The maximum nonsedating doses were : morphine , 3.2 mg/kg ; CNSB002 10.0 mg/kg ; 5.0 mg/kg CNSB002 with morphine 3.2 mg/kg in combination .
O O O O O O O O B-ChemicalEntity O O O O B-ChemicalEntity O O O O O B-ChemicalEntity O B-ChemicalEntity O O O O O