Here , we show that simultaneous overexpression of the mitotic checkpoint protein Mad2 with Kras ( G12D ) or Her2 in mammary glands of adult mice results in mitotic checkpoint overactivation and a delay in tumor onset .
O O O O O O O O O O O O B-GeneOrGeneProduct O B-GeneOrGeneProduct O B-GeneOrGeneProduct O O B-GeneOrGeneProduct O O O O O B-OrganismTaxon O O O O O O O O O B-DiseaseOrPhenotypicFeature O O