In the inpatient setting , the frequency of QT interval prolongation with methadone treatment , its dose dependence , and the importance of cofactors such as drug-drug interactions remain unknown .
O O B-OrganismTaxon O O O O O B-DiseaseOrPhenotypicFeature I-DiseaseOrPhenotypicFeature I-DiseaseOrPhenotypicFeature O B-ChemicalEntity O O O O O O O O O O O O O O O O O O