Inhibition of type I TGFb receptors ALK1/2/3/6 responsible for phosphorylation of Smad1/5/8 reduced the hyperproliferation seen in c.474delA fibroblasts .
O O B-GeneOrGeneProduct I-GeneOrGeneProduct I-GeneOrGeneProduct I-GeneOrGeneProduct B-GeneOrGeneProduct O O O O B-GeneOrGeneProduct O O O O O B-SequenceVariant O O