To elucidate the pathogenic mechanism producing oligodontia phenotype caused by this mutation , we analyzed the binding of wild-type and mutant PAX9 paired domain protein to double-stranded DNA targets .
O O O O O O B-DiseaseOrPhenotypicFeature I-DiseaseOrPhenotypicFeature O O O O O O O O O O O O O B-GeneOrGeneProduct O O O O O O O O