METHODS : Allele frequencies of SP-A1 , SP-A2 , and SP-D were determined by polymerase chain reaction in 303 patients with microbiologically proven meningococcal disease , including 18 patients who died , and 222 healthy control subjects .
O O O O O B-GeneOrGeneProduct O B-GeneOrGeneProduct O O B-GeneOrGeneProduct O O O O O O O O B-OrganismTaxon O O O B-DiseaseOrPhenotypicFeature I-DiseaseOrPhenotypicFeature O O O B-OrganismTaxon O B-DiseaseOrPhenotypicFeature O O O O O O O