Expanding clinical spectrum of non-autoimmune hyperthyroidism due to an activating germline mutation , p.M453T , in the thyrotropin receptor gene .
O O O O B-DiseaseOrPhenotypicFeature I-DiseaseOrPhenotypicFeature O O O O O O O B-SequenceVariant O O O B-GeneOrGeneProduct I-GeneOrGeneProduct O O