The genetic polymorphism rs1052133 , which leads to substitution of the amino acid at codon 326 from Ser to Cys , shows functional differences , namely a decrease in enzyme activity in hOGG1-Cys326 .
O O O B-SequenceVariant O O O O O O O O O O O B-SequenceVariant I-SequenceVariant I-SequenceVariant I-SequenceVariant I-SequenceVariant O O O O O O O O O O O O I-SequenceVariant O