Moreover , CBKOTg mice reduced levels of phosphorylated mitogen-activated protein kinase ( extracellular signal-regulated kinase ) 1/2 and cAMP response element-binding protein at Ser-133 and synaptic molecules such as N-methyl-D-aspartate receptor 1 ( NMDA receptor 1 ) , NMDA receptor 2A , PSD-95 and synaptophysin in the subiculum compared with Tg mice .
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