A valine ( Val ) to alanine ( Ala ) substitution at amino acid 16 , occurring in the mitochondrial targeting sequence of the MnSOD gene , has been associated with an increase in urolithiasis risk .
O B-SequenceVariant I-SequenceVariant I-SequenceVariant I-SequenceVariant I-SequenceVariant I-SequenceVariant I-SequenceVariant I-SequenceVariant I-SequenceVariant I-SequenceVariant I-SequenceVariant I-SequenceVariant I-SequenceVariant I-SequenceVariant O O O O O O O O O B-GeneOrGeneProduct O O O O O O O O O B-DiseaseOrPhenotypicFeature O O