A CASP8 promoter region six-nucleotide deletion/insertion ( -652 6N ins/del ) variant and a coding region D302H polymorphism are reportedly important in cancer development , but no reported study has assessed the associations of these genetic variations with risk of head and neck cancer .
O B-GeneOrGeneProduct O O O O O B-SequenceVariant I-SequenceVariant I-SequenceVariant O O O O O O B-SequenceVariant O O O O O B-DiseaseOrPhenotypicFeature O O O O O O O O O O O O O O O O O B-DiseaseOrPhenotypicFeature I-DiseaseOrPhenotypicFeature I-DiseaseOrPhenotypicFeature I-DiseaseOrPhenotypicFeature O