In 5 mM glucose medium , we observed a stepwise activation of oxidative metabolism during cell differentiation that was characterized by peroxisome proliferator-activated receptor-g coactivator 1a ( PGC-1a ) -dependent stimulation of mitochondrial biogenesis and function , with concomitant reduction of the glycolytic enzyme content .
O O O B-ChemicalEntity O O O O O O O O O O O O O O O O O B-GeneOrGeneProduct I-GeneOrGeneProduct I-GeneOrGeneProduct I-GeneOrGeneProduct I-GeneOrGeneProduct O B-GeneOrGeneProduct O O O O O O O O O O O O O O O O O O