RESULTS : When compared with Crohn 's disease patients without CARD15 mutations , the presence of at least one CARD15 variant in Crohn 's disease patients more frequently led to gASCA positivity ( 66.1 % versus 51.5 % , p < 0.0001 ) and ALCA positivity ( 43.3 % versus 34.9 % , p = 0.018 ) and higher gASCA titers ( 85.7 versus 51.8 ELISA units , p < 0.0001 ) , independent of ileal involvement .
O O O O O B-DiseaseOrPhenotypicFeature I-DiseaseOrPhenotypicFeature I-DiseaseOrPhenotypicFeature B-OrganismTaxon O B-GeneOrGeneProduct O O O O O O O O B-GeneOrGeneProduct O O B-DiseaseOrPhenotypicFeature I-DiseaseOrPhenotypicFeature I-DiseaseOrPhenotypicFeature B-OrganismTaxon O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O