Methadone , an agonist of OPRM1 , enhances the sensitivity of parental leukemic cells , but not OPRM1-depleted cells , to L-asparaginase treatment , indicating that OPRM1 is required for the synergistic action of L-asparaginase and methadone , and that OPRM1 loss promotes leukemic cell survival likely through downregulation of the OPRM1-mediated apoptotic pathway .
B-ChemicalEntity O O O O B-GeneOrGeneProduct O O O O O O B-DiseaseOrPhenotypicFeature O O O O B-GeneOrGeneProduct O O O B-ChemicalEntity O O O O B-GeneOrGeneProduct O O O O O O O B-ChemicalEntity O B-ChemicalEntity O O O B-GeneOrGeneProduct O O B-DiseaseOrPhenotypicFeature O O O O O O O B-GeneOrGeneProduct O O O