The deletion of any of these five genes enhanced the toxicity of alpha-syn as judged by growth defects compared with wild-type cells expressing alpha-syn , which indicates that these genes protect cells from alpha-syn .
O O O O O O O O O O B-DiseaseOrPhenotypicFeature O B-GeneOrGeneProduct O O O O O O O O O O B-GeneOrGeneProduct O O O O O O O O O B-GeneOrGeneProduct O