In contrast , mPGES-1 -/- mice were largely resistant to lithium-induced polyuria and a urine concentrating defect , accompanied by nearly complete blockade of high urine PGE ( 2 ) and cAMP output .
O O O B-GeneOrGeneProduct O B-OrganismTaxon O O O O B-ChemicalEntity B-DiseaseOrPhenotypicFeature O O O O O O O O O O O O O O B-ChemicalEntity I-ChemicalEntity I-ChemicalEntity I-ChemicalEntity O B-ChemicalEntity O O