A two base pair deletion in the PQBP1 gene is associated with microphthalmia , microcephaly , and mental retardation .
O O O O O O O B-GeneOrGeneProduct O O O O B-DiseaseOrPhenotypicFeature O B-DiseaseOrPhenotypicFeature O O B-DiseaseOrPhenotypicFeature I-DiseaseOrPhenotypicFeature O