A derivative of rDEN2Delta30 , designated rDEN2Delta30-4995 , was generated by incorporation of a point mutation previously identified in the NS3 gene of DEN-4 and was found to be more attenuated than rDEN2Delta30 in SCID-HuH-7 mice .
O O O I-SequenceVariant O O I-SequenceVariant O O O O O O O O O O O O O B-GeneOrGeneProduct O O B-OrganismTaxon O O O O O O O O I-SequenceVariant O B-CellLine B-OrganismTaxon O