One of the common functional polymorphisms of GSTP1 is A > G at nucleotide 313 , which results in an amino acid substitution ( Ile105Val ) at the substrate binding site of GSTP1 and reduces catalytic activity of GSTP1 .
O O O O O O O B-GeneOrGeneProduct O B-SequenceVariant I-SequenceVariant I-SequenceVariant I-SequenceVariant I-SequenceVariant I-SequenceVariant O O O O O O O O O B-SequenceVariant O O O O O O O B-GeneOrGeneProduct O O O O O B-GeneOrGeneProduct O