Strikingly , four of the five genes are specific for alpha-syn in that they fail to protect cells from the toxicity of the two inherited mutants A30P or A53T .
O O O O O O O O O O B-GeneOrGeneProduct O O O O O O O O O B-DiseaseOrPhenotypicFeature O O O O O B-SequenceVariant O B-SequenceVariant O