Doxorubicin treatment resulted in heavy proteinuria ( > 100 mg protein/mg crea ) in 15/44 of sgk1 ( +/+ ) and 15/44 of sgk1 ( -/- ) mice leading to severe nephrotic syndrome with ascites , lipidemia , and hypoalbuminemia in both genotypes .
B-ChemicalEntity O O O O B-DiseaseOrPhenotypicFeature O O O O O B-ChemicalEntity O O O O B-GeneOrGeneProduct O O O O O O B-GeneOrGeneProduct O O O B-OrganismTaxon O O O B-DiseaseOrPhenotypicFeature I-DiseaseOrPhenotypicFeature O B-DiseaseOrPhenotypicFeature O B-DiseaseOrPhenotypicFeature O O B-DiseaseOrPhenotypicFeature O O O O