The development of antibodies reflects a loss of tolerance to intestinal bacteria that underlies Crohn 's disease , resulting in an exaggerated adaptive immune response to these bacteria .
O O O O O O O O O O O B-OrganismTaxon O O B-DiseaseOrPhenotypicFeature I-DiseaseOrPhenotypicFeature I-DiseaseOrPhenotypicFeature O O O O O O O O O O B-OrganismTaxon O