The TP53 tumor-suppressor gene was mutated in all OSCs with documented NF1 mutation , suggesting that the pathways regulated by these two tumor-suppressor proteins often cooperate in the development of ovarian carcinomas with serous differentiation .
O B-GeneOrGeneProduct B-DiseaseOrPhenotypicFeature O O O O O B-DiseaseOrPhenotypicFeature O O B-GeneOrGeneProduct O O O O O O O O O O B-DiseaseOrPhenotypicFeature O O O O O O O B-DiseaseOrPhenotypicFeature I-DiseaseOrPhenotypicFeature O O O O