Whereas imatinib and ponatinib bind potently to both the DDR and ABL kinases , the hydrophobic interactions of the ABL P-loop appear poorly satisfied by DDR1-IN-1 suggesting a structural basis for its DDR1 selectivity .
O B-ChemicalEntity O B-ChemicalEntity O O O O O B-GeneOrGeneProduct O B-GeneOrGeneProduct O O O O O O O B-GeneOrGeneProduct O O O O O B-ChemicalEntity O O O O O O B-GeneOrGeneProduct O O