Tak1 ( col2 ) mice displayed severe chondrodysplasia with runting , impaired formation of secondary centres of ossification , and joint abnormalities including elbow dislocation and tarsal fusion .
B-GeneOrGeneProduct O B-GeneOrGeneProduct O B-OrganismTaxon O O B-DiseaseOrPhenotypicFeature O O O O O O O O O O O O B-DiseaseOrPhenotypicFeature I-DiseaseOrPhenotypicFeature O B-DiseaseOrPhenotypicFeature I-DiseaseOrPhenotypicFeature O B-DiseaseOrPhenotypicFeature I-DiseaseOrPhenotypicFeature O