SRD5A2 gene analysis revealed 2 consecutive mutations in exon 4 , each located in a different allele : 1 ) a T nucleotide deletion , which predicts a frameshift mutation from codon 219 , and 2 ) a missense mutation at codon 227 , where the substitution of guanine ( CGA ) by adenine ( CAA ) predicts a glutamine replacement of arginine ( R227Q ) .
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