RESULTS : AA genotype of A 1166C polymorphism was associated with lower minimal systolic blood pressure ( SBP ) and diastolic blood pressure ( DBP ) during HUT compared with other genotypes ( minimal SBP : AA 59.6+/-21,8 , AC 79.9+/-22.7 , CC 65.4+/-22.7 mmHg , P=0.007 ) , ( minimal DBP : AA 36.4+/-22.7 , AC 52.3+/-22.9 , CC 45.4+/-19.5 mmHg , P=0.007 ) .AA genotype was also associated with higher SDNN compared to other genotypes in the early phase of HUT ( SDNN in 5 minutes of tilt : AA 59.7+/-24.6 , AC 50.6+/-20.6 , CC 46.0+/-13.2 , P=0.01 ) and at syncope occurrence ( SDNN : AA 71.0+/-20.9 , AC 58.2+/-17.9 , CC 58+/-10 , P=0.04 ) CONCLUSION : AA genotype of A 1166C polymorphism in the ATR1 gene may be associated with hypotension and decline in sympathetic tone during HUT .
O O O O O B-SequenceVariant I-SequenceVariant O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O B-DiseaseOrPhenotypicFeature O O O O O O O O O O O O O O O O O O O O B-SequenceVariant I-SequenceVariant O O O B-GeneOrGeneProduct O O O O O B-DiseaseOrPhenotypicFeature O O O O O O O O