The interplay between C-C chemokine receptor type 5 ( CCR5 ) host genetic background , disease progression , and intrahost HIV-1 evolutionary dynamics remains unclear because differences in viral evolution between hosts limit the ability to draw conclusions across hosts stratified into clinically relevant populations .
O O O B-GeneOrGeneProduct I-GeneOrGeneProduct I-GeneOrGeneProduct I-GeneOrGeneProduct I-GeneOrGeneProduct O B-GeneOrGeneProduct O O O O O O O O O O B-OrganismTaxon O O O O O O O O O O O O O O O O O O O O O O O O O