CONCLUSIONS : These findings indicate that the promoter polymorphism of IRF5 is a genetic factor conferring predisposition to RA , and that it contributes considerably to disease pathogenesis in patients that were SE negative .
O O O O O O O O O O B-GeneOrGeneProduct O O O O O O O B-DiseaseOrPhenotypicFeature O O O O O O O O O O B-OrganismTaxon O O O O O