The d-myo-inositol 1,4,5-trisphosphate ( IP ( 3 ) ) /Ca ( 2+ ) /protein kinase C ( PKC ) /mitogen-activated protein kinase pathway regulates cholangiocarcinoma growth .
O B-ChemicalEntity I-ChemicalEntity O B-ChemicalEntity I-ChemicalEntity I-ChemicalEntity I-ChemicalEntity O I-ChemicalEntity I-ChemicalEntity I-ChemicalEntity I-ChemicalEntity I-GeneOrGeneProduct I-GeneOrGeneProduct I-GeneOrGeneProduct O B-GeneOrGeneProduct O I-GeneOrGeneProduct I-GeneOrGeneProduct I-GeneOrGeneProduct O O B-DiseaseOrPhenotypicFeature O O