Consistent with this premise , patient leukemic cells with relatively high levels of OPRM1 are more sensitive to L-asparaginase treatment compared to OPRM1-depleted leukemic cells , further indicating that OPRM1 loss has a crucial role in L-asparaginase resistance in leukemic patients .
O O O O O B-OrganismTaxon B-DiseaseOrPhenotypicFeature O O O O O O B-GeneOrGeneProduct O O O O B-ChemicalEntity O O O B-GeneOrGeneProduct B-DiseaseOrPhenotypicFeature O O O O O B-GeneOrGeneProduct O O O O O O B-ChemicalEntity O O B-DiseaseOrPhenotypicFeature B-OrganismTaxon O