Notably , following treatment with Hsp27 siRNA or pcDNA3.1-Hsp27 , it was found that iopamidol enhanced or weakened the upregulation of Bax/caspase-3 and downregulation of Bcl-2 in the HK2 cells , respectively .
O O O O O B-GeneOrGeneProduct O O I-GeneOrGeneProduct O O O O O B-ChemicalEntity O O O O O O I-GeneOrGeneProduct O O O B-GeneOrGeneProduct O O B-CellLine O O O O