OBJECTIVE : The goal of this study was to determine whether mutations of meiotic genes , such as disrupted meiotic cDNA ( DMC1 ) , MutS homolog ( MSH4 ) , MSH5 , and S. cerevisiae homolog ( SPO11 ) , were associated with premature ovarian failure ( POF ) .
O O O O O O O O O O O O O O O O O O O O O O B-GeneOrGeneProduct O O B-GeneOrGeneProduct O O B-GeneOrGeneProduct O O B-GeneOrGeneProduct O O B-OrganismTaxon I-OrganismTaxon O O B-GeneOrGeneProduct O O O O O B-DiseaseOrPhenotypicFeature I-DiseaseOrPhenotypicFeature I-DiseaseOrPhenotypicFeature O B-DiseaseOrPhenotypicFeature O O