METHODS : In this study , we evaluated the performance of dopamine beta-hydroxylase knockout ( Dbh -/- ) mice , which lack norepinephrine ( NE ) , in the elevated plus maze ( EPM ) to examine the contribution of noradrenergic signaling to cocaine-induced anxiety .
O O O O O O O O O O O B-GeneOrGeneProduct I-GeneOrGeneProduct O O B-GeneOrGeneProduct O O B-OrganismTaxon O O O B-ChemicalEntity O B-ChemicalEntity O O O O O O O O O O O O O O O O O O B-ChemicalEntity B-DiseaseOrPhenotypicFeature O