Consistent with impaired growth , PKCalpha knockdown increased levels of the cyclin-dependent kinase ( CDK ) inhibitors p21 ( Cip1/WAF1 ) ( p21 ) and p27 ( Kip1 ) ( p27 ) .
O O O O O B-GeneOrGeneProduct O O O O O B-GeneOrGeneProduct I-GeneOrGeneProduct O B-GeneOrGeneProduct O O B-GeneOrGeneProduct O B-GeneOrGeneProduct O O B-GeneOrGeneProduct O O B-GeneOrGeneProduct O B-GeneOrGeneProduct O O B-GeneOrGeneProduct O O