CONCLUSIONS : Those novel compound heterozygous mutations were thought to contribute to the loss of CHST6 function , which induced the abnormal metabolism of keratan sulfate ( KS ) that deposited in the corneal stroma .
O O O O O O O O O O O O O O O B-GeneOrGeneProduct O O O O O O O O B-ChemicalEntity I-ChemicalEntity O B-ChemicalEntity O O O O O O O O