The sG145R mutation strongly reduced HBsAg levels and was able to fully restore the impaired replication of LAM-resistant HBV mutants to the levels of wild-type HBV , and PC or BCP mutations further enhanced viral replication .
O I-SequenceVariant O O O B-ChemicalEntity O O O O O O O O O O O B-ChemicalEntity B-OrganismTaxon O O O O O O B-OrganismTaxon O O B-GeneOrGeneProduct O O O O O O O O