Notably , administration of a ghrelin receptor antagonist further reduced blood glucose levels into the markedly hypoglycemic range in overnight-fasted , streptozotocin-treated Gcgr ( -/- ) mice .
O O O O O B-GeneOrGeneProduct I-GeneOrGeneProduct O O O B-ChemicalEntity I-ChemicalEntity O O O O O O O O O B-ChemicalEntity B-GeneOrGeneProduct O O O B-OrganismTaxon O