With the advent of next-generation sequencing technologies , the homozygous mutations T71N and A190T in the neuronal calcium sensor ( NCS ) hippocalcin were identified as the genetic cause of primary isolated dystonia ( DYT2 dystonia ) .
O O O O O O O O O O O B-SequenceVariant O B-SequenceVariant O O B-GeneOrGeneProduct I-GeneOrGeneProduct I-GeneOrGeneProduct O B-GeneOrGeneProduct O B-GeneOrGeneProduct O O O O O O O B-DiseaseOrPhenotypicFeature I-DiseaseOrPhenotypicFeature I-DiseaseOrPhenotypicFeature O B-GeneOrGeneProduct B-DiseaseOrPhenotypicFeature O O