CONCLUSIONS : Dexamethasone treatment is effective in controlling the premature pubarche , hypoglycemia , hypertension , and hypokalemia in this child case , wherein arginine 714 plays a key role in the proper formation of the ligand-binding pocket and the AF-2 surface of the GR alpha LBD .
O O B-ChemicalEntity O O O O O O B-DiseaseOrPhenotypicFeature I-DiseaseOrPhenotypicFeature O B-DiseaseOrPhenotypicFeature O B-DiseaseOrPhenotypicFeature O O B-DiseaseOrPhenotypicFeature O O O O O O B-SequenceVariant I-SequenceVariant O O O O O O O O O O O O O O O O O O B-GeneOrGeneProduct I-GeneOrGeneProduct O O