The C139T mutation , predicted to result in the substitution of an arginine by a tryptophan ( R47W ) in the N-terminal subdomain , affected conserved residues in the PAX9 paired domain .
O B-SequenceVariant O O O O O O O O O O B-SequenceVariant I-SequenceVariant I-SequenceVariant I-SequenceVariant O B-SequenceVariant O O O O O O O O O O O B-GeneOrGeneProduct O O O