Although T4 treatment suppressed TSH secretion , it had no effect on skeletal maturation , linear growth , or bone mineralization , thus demonstrating profound tissue resistance to thyroid hormone .
O B-ChemicalEntity O O B-GeneOrGeneProduct O O O O O O O O O O O O O O O O O O O O O B-DiseaseOrPhenotypicFeature I-DiseaseOrPhenotypicFeature I-DiseaseOrPhenotypicFeature I-DiseaseOrPhenotypicFeature O