Whether proteinuria was due to sirolimus or only a consequence of calcineurin inhibitors withdrawal remained unsolved until high range proteinuria has been observed during sirolimus therapy in islet transplantation and in patients who received sirolimus de novo .
O B-DiseaseOrPhenotypicFeature O O O B-ChemicalEntity O O O O O B-ChemicalEntity I-ChemicalEntity O O O O O O B-DiseaseOrPhenotypicFeature O O O O B-ChemicalEntity O O O O O O B-OrganismTaxon O O B-ChemicalEntity O O O