As previously observed for glioblastomas in Europe , there was a positive association between EGFR amplification and p16 deletion ( p=0.009 ) , whereas there was an inverse association between TP53 mutations and p16 deletion ( p=0.049 ) in glioblastomas in Japan .
O O O O B-DiseaseOrPhenotypicFeature O O O O O O O O O B-GeneOrGeneProduct O O B-GeneOrGeneProduct O O O O O O O O O O O O B-GeneOrGeneProduct O O B-GeneOrGeneProduct O O O O O B-DiseaseOrPhenotypicFeature O O O