The first is the frameshift mutation ( P686fs ) caused by the insertion of the four nucleotides CCCC in exon 16 ( 2172_2173insCCCC ) that is predicted to terminate translation before the catalytic serine .
O O O O O O O B-SequenceVariant O O O O B-SequenceVariant I-SequenceVariant I-SequenceVariant I-SequenceVariant I-SequenceVariant I-SequenceVariant O O O O B-SequenceVariant O O O O O O O O O O O O