STUDY DESIGN : Wild-type ( WT ) and superoxide dismutase 1 ( SOD1 ) -overexpressing day 8.75 embryos from nondiabetic WT control with SOD1 transgenic male and diabetic WT female with SOD1 transgenic male were analyzed for ER stress markers : C/EBP-homologous protein ( CHOP ) , calnexin , eukaryotic initiation factor 2a ( eIF2a ) , protein kinase ribonucleic acid ( RNA ) -like ER kinase ( PERK ) , binding immunoglobulin protein , protein disulfide isomerase family A member 3 , kinases inositol-requiring protein-1a ( IRE1a ) , and the X-box binding protein ( XBP1 ) messenger RNA ( mRNA ) splicing .
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