CONCLUSIONS : Using patient demographics , tumor characteristics , and CGP , we show that GIST lacking alterations in canonical genes occur in younger patients , frequently metastasize to lymph nodes , and most contain deleterious genomic alterations , including gene fusions involving FGFR1 and NTRK3 .
O O O B-OrganismTaxon O O B-DiseaseOrPhenotypicFeature O O O O O O O O B-DiseaseOrPhenotypicFeature O O O O O O O O B-OrganismTaxon O O B-DiseaseOrPhenotypicFeature I-DiseaseOrPhenotypicFeature I-DiseaseOrPhenotypicFeature I-DiseaseOrPhenotypicFeature O O O O O O O O O O O O B-GeneOrGeneProduct O B-GeneOrGeneProduct O