Our findings suggest that the G51S PNP polymorphism is associated with a faster rate of cognitive decline in AD patients , highlighting the important role of purine metabolism in the progression of this neurodegenerative disorder .
O O O O O B-SequenceVariant B-GeneOrGeneProduct O O O O O O O O B-DiseaseOrPhenotypicFeature I-DiseaseOrPhenotypicFeature O B-DiseaseOrPhenotypicFeature B-OrganismTaxon O O O O O O O O O O O O O B-DiseaseOrPhenotypicFeature I-DiseaseOrPhenotypicFeature O