Pharmacological inhibition of HIF-1a activity using YC1 and thiamine repletion both reduced expression of pro-apoptotic HIF-1a target genes and apoptotic cell death in TD .
O O O B-GeneOrGeneProduct O O B-GeneOrGeneProduct O B-ChemicalEntity O O O O O O B-GeneOrGeneProduct O O O O O O O B-DiseaseOrPhenotypicFeature O