Recombinant OGT bearing the p.Arg284Pro mutation was prone to unfolding and exhibited reduced glycosylation activity against a complex array of glycosylation substrates and proteolytic processing of the transcription factor host cell factor 1 , which is also encoded by an XLID-associated gene .
O B-GeneOrGeneProduct O O B-SequenceVariant O O O O O O O O O O O O O O O O O O O O O O O O B-GeneOrGeneProduct I-GeneOrGeneProduct I-GeneOrGeneProduct I-GeneOrGeneProduct O O O O O O O B-DiseaseOrPhenotypicFeature O O