The presence of the D401H mutation may predispose subjects to obesity , hypertension , and other manifestations of the metabolic syndrome .
O O O O B-SequenceVariant O O O O O B-DiseaseOrPhenotypicFeature O B-DiseaseOrPhenotypicFeature O O O O O O B-DiseaseOrPhenotypicFeature I-DiseaseOrPhenotypicFeature O