Direct sequencing of the TRbeta gene revealed a heterozygous transition 1284A > C in exon 9 resulting in substitution of glutamic acid 333 by aspartic acid residue ( E333D ) .
O O O O B-GeneOrGeneProduct O O O O O B-SequenceVariant I-SequenceVariant I-SequenceVariant O O O O O O O B-SequenceVariant I-SequenceVariant I-SequenceVariant I-SequenceVariant I-SequenceVariant I-SequenceVariant O O B-SequenceVariant O O