Of them , two patients carrying E359K mutation were from two generations in one family with ventricular septal defect ( VSD ) .
O O O O B-OrganismTaxon O B-SequenceVariant O O O O O O O O O B-DiseaseOrPhenotypicFeature I-DiseaseOrPhenotypicFeature I-DiseaseOrPhenotypicFeature O B-DiseaseOrPhenotypicFeature O O