Several studies have reported that , compared with wild-type individuals , CYP2C19 variant allele carriers exhibit a significantly lower capacity to metabolize clopidogrel into its active metabolite and inhibit platelet activation , and are therefore at significantly higher risk of adverse cardiovascular events .
O O O O O O O O O O O B-GeneOrGeneProduct O O O O O O O O O O B-ChemicalEntity O O O O O O O O O O O O O O O O O O O O O