CONCLUSIONS : These results suggest that bupivacaine stimulates COX-2 gene expression after tissue injury , which is associated with higher PGE2 production and pain after the local anesthetic effect dissipates .
O O O O O O B-ChemicalEntity O B-GeneOrGeneProduct O O O B-DiseaseOrPhenotypicFeature I-DiseaseOrPhenotypicFeature O O O O O O B-GeneOrGeneProduct O O B-DiseaseOrPhenotypicFeature O O O O O O O