Using a combination of homozygosity mapping and candidate gene approach , we have identified a homozygous single base pair deletion ( c.1052delA ) in SP7/Osterix ( OSX ) in an Egyptian child with recessive osteogenesis imperfecta .
O O O O O O O O O O O O O O O O B-SequenceVariant I-SequenceVariant I-SequenceVariant I-SequenceVariant O B-SequenceVariant O O I-GeneOrGeneProduct O B-GeneOrGeneProduct O O O O O O B-DiseaseOrPhenotypicFeature I-DiseaseOrPhenotypicFeature I-DiseaseOrPhenotypicFeature O