We therefore systematically analyzed the functional impact of the most prevalent immune escape variants , the sG145R and sP120T mutants , on the viral replication efficacy and antiviral drug susceptibility of common treatment-associated mutants with resistance to lamivudine ( LAM ) and/or HBeAg negativity .
O O O O O O O O O O O O O O O O I-SequenceVariant O I-SequenceVariant O O O O O O O O O O O O O O O O O O B-ChemicalEntity O B-ChemicalEntity O O B-ChemicalEntity O O