Among the family members , patients with the homozygous SLURP1 ( previously known as ARS component B ) mutation are prone to melanoma and viral infection , which might link to defective T-cell function as well as a derangement of epidermal homeostasis .
O O O O O B-OrganismTaxon O O O B-GeneOrGeneProduct O O O O O O O O O O O O B-DiseaseOrPhenotypicFeature O B-DiseaseOrPhenotypicFeature I-DiseaseOrPhenotypicFeature O O O O O O O O O O O O O O O O O