Our studies establish that TRa1 has an essential role in the developing and adult skeleton and predict that patients with different THRA mutations will display variable responses to T4 treatment , which depend on the severity of the causative mutation .
O O O O B-GeneOrGeneProduct O O O O O O O O O O O O O B-OrganismTaxon O O B-GeneOrGeneProduct O O O O O O B-ChemicalEntity O O O O O O O O O O O O