In conclusion , MT induction halts BCNU-induced hippocampal toxicity as it prevented GR inhibition and GSH depletion and counteracted the increased levels of TNFalpha , MDA and caspase-3 activity with subsequent preservation of cognition .
O O O B-ChemicalEntity O O B-ChemicalEntity O B-DiseaseOrPhenotypicFeature O O O B-GeneOrGeneProduct O O B-ChemicalEntity O O O O O O O B-GeneOrGeneProduct O B-ChemicalEntity O B-GeneOrGeneProduct O O O O O O O