To determine the pathogenic importance of CB depletions in AD models , we crossed 5 familial AD mutations ( 5XFAD ; Tg ) mice with CB knock-out ( CBKO ) mice and generated a novel line CBKO.5XFAD ( CBKOTg ) mice .
O O O O O O B-GeneOrGeneProduct O O B-DiseaseOrPhenotypicFeature O O O O O O B-DiseaseOrPhenotypicFeature O O I-DiseaseOrPhenotypicFeature O O O B-OrganismTaxon O B-GeneOrGeneProduct O O B-GeneOrGeneProduct O B-OrganismTaxon O O O O O B-GeneOrGeneProduct O B-GeneOrGeneProduct O B-OrganismTaxon O