These findings provide the first in vivo evidence in a mammalian system that TAK1 is required for BMP signalling and functions as an upstream activating kinase for Smad1/5/8 in addition to its known role in regulating MAP kinase pathways .
O O O O O O O O O O O O O B-GeneOrGeneProduct O O O B-GeneOrGeneProduct O O O O O O O O O B-GeneOrGeneProduct O O O O O O O O B-GeneOrGeneProduct I-GeneOrGeneProduct O O