A missense mutation in the human PER2 gene has previously been linked to advanced sleep phase syndrome ( ASPS ) .
O O O O O B-OrganismTaxon B-GeneOrGeneProduct O O O O O O B-DiseaseOrPhenotypicFeature I-DiseaseOrPhenotypicFeature I-DiseaseOrPhenotypicFeature I-DiseaseOrPhenotypicFeature O B-DiseaseOrPhenotypicFeature O O