In a prospective study involving 74 MFA patients and 170 control subjects , we identified four patients harboring a heterozygous single nucleotide polymorphism in exon 6 of the PrlR gene , encoding Ile ( 146 ) -- > Leu substitution in its extracellular domain .
O O O O O O B-DiseaseOrPhenotypicFeature B-OrganismTaxon O O O O O O O O B-OrganismTaxon O O O O O O O O O O O B-GeneOrGeneProduct O O O B-SequenceVariant I-SequenceVariant I-SequenceVariant I-SequenceVariant I-SequenceVariant I-SequenceVariant I-SequenceVariant O O O O O O