However , all cases show similar clinical features , highlighting the importance of functional plakophilin 1 in maintaining desmosomal adhesion in skin , as well as the role of this protein in aspects of ectodermal development .
O O O O O O O O O O O O O O B-GeneOrGeneProduct I-GeneOrGeneProduct O O O O O O O O O O O O O O O O O O O O O