In the present study , we investigated whether 50 mg/kg per day , p.o. , Ato could prevent endothelial NO synthase ( eNOS ) downregulation and the increase in O2- in Sprague-Dawley ( SD ) rats , thereby reducing blood pressure .
O O O O O O O O O O O O O O O B-ChemicalEntity O O B-GeneOrGeneProduct I-GeneOrGeneProduct I-GeneOrGeneProduct O B-GeneOrGeneProduct O O O O O O B-ChemicalEntity O O O O O B-OrganismTaxon O O O O O O