Importantly , this is the first experimental evidence that removal of CB from amyloid precursor protein/presenilin transgenic mice aggravates AD pathogenesis , suggesting that CB has a critical role in AD pathogenesis .
O O O O O O O O O O O B-GeneOrGeneProduct O B-GeneOrGeneProduct I-GeneOrGeneProduct I-GeneOrGeneProduct O B-OrganismTaxon O B-DiseaseOrPhenotypicFeature O O O O B-GeneOrGeneProduct O O O O O B-DiseaseOrPhenotypicFeature O O