RESULTS : Nontoxic doses of dexrazoxane reduced myelosuppression and weight loss from daunorubicin and etoposide in mice and antagonized their antiproliferative effects in the colony assay ; however , dexrazoxane neither reduced myelosuppression , weight loss , nor the in vitro cytotoxicity from doxorubicin .
O O O O O B-ChemicalEntity O B-DiseaseOrPhenotypicFeature O B-DiseaseOrPhenotypicFeature I-DiseaseOrPhenotypicFeature O B-ChemicalEntity O B-ChemicalEntity O B-OrganismTaxon O O O O O O O O O O O O B-ChemicalEntity O O B-DiseaseOrPhenotypicFeature O B-DiseaseOrPhenotypicFeature I-DiseaseOrPhenotypicFeature O O O O O B-DiseaseOrPhenotypicFeature O B-ChemicalEntity O