CONCLUSION : Taken together with previous studies of human PPARG mutations , these findings suggest that PPAR-gamma deficiency due either to haploinsufficiency or to substantial activity loss due to dominant negative interference of the normal allele product 's function can each contribute to the FPLD3 phenotype .
O O O O O O O O B-OrganismTaxon B-GeneOrGeneProduct O O O O O O B-GeneOrGeneProduct O O O O O O O O O O O O O O O O O O O O O O O O O O O B-DiseaseOrPhenotypicFeature O O