Consistent with hypoxia/ischemia , TD stabilizes and activates Hypoxia Inducible Factor-1a ( HIF-1a ) under physiological oxygen levels .
O O I-DiseaseOrPhenotypicFeature O B-DiseaseOrPhenotypicFeature O O O B-GeneOrGeneProduct I-GeneOrGeneProduct I-GeneOrGeneProduct O B-GeneOrGeneProduct O O O B-ChemicalEntity O O