In its regulatory subunit , p85alpha , there is a common amino acid substitution ( the Met326Ile polymorphism ) , and this amino acid may be crucial for the function of the p85alpha regulatory subunit and PI3-kinase .
O O O O O B-GeneOrGeneProduct O O O O O O O O O O B-SequenceVariant O O O O O O O O O O O O O O O B-GeneOrGeneProduct O O O B-GeneOrGeneProduct O