In conclusion , HFD-induced obese rats are highly sensitized to doxorubicin-induced cardiotoxicity by substantially downregulating cardiac mitochondrial ATP generation , increasing oxidative stress and downregulating the JAK/STAT3 pathway .
O O O O B-DiseaseOrPhenotypicFeature B-OrganismTaxon O O O O B-ChemicalEntity B-DiseaseOrPhenotypicFeature O O O O O B-ChemicalEntity O O O O O O O O I-GeneOrGeneProduct O O