The MLH1 -93 variant allele was also over-represented in t-AML cases when compared to de novo AML cases ( 36.9 % , n = 420 ) and healthy controls ( 36.3 % , n = 952 ) , and was associated with a significantly increased risk of developing t-AML ( odds ratio 5.31 , 95 % confidence interval 1.40 to 20.15 ) , but only in patients previously treated with a methylating agent .
O B-GeneOrGeneProduct O O O O O O O I-DiseaseOrPhenotypicFeature O O O O O O B-DiseaseOrPhenotypicFeature O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O I-DiseaseOrPhenotypicFeature O O O O O O O O O O O O O O O O O B-OrganismTaxon O O O O O O O