Furthermore , IGF-1R is related with PI3K/Akt/mTOR signaling pathway and enhanced autophagy-associated protein expression , which was verified following treatment with the PI3K inhibitor LY294002 .
O O B-GeneOrGeneProduct O O O B-GeneOrGeneProduct O O O O O O O O O O O O O O O B-GeneOrGeneProduct O B-ChemicalEntity O