Both polymorphisms were in strong linkage disequilibrium ( D ' = 0.71 , P < .001 ) , and the 3R/-6 base pair ( bp ) haplotype showed a significant overall survival benefit compared with the most prevalent haplotype 2R/+6bp ( HR = 0.42 ; 95 % CI , 0.20 to 0.85 ; P = .017 ) .
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