Inhibition of caspases , RIP1 , or RIP3 blocks radiation/TNFa-induced cell death , whereas inhibition of RIP1 blocks TNFa-induced caspase activation , suggesting that caspases and RIP1 act sequentially to mediate the non-compensatory cell death pathways .
O O B-GeneOrGeneProduct O B-GeneOrGeneProduct O O B-GeneOrGeneProduct O I-GeneOrGeneProduct O O O O O O B-GeneOrGeneProduct O B-GeneOrGeneProduct B-GeneOrGeneProduct O O O O B-GeneOrGeneProduct O B-GeneOrGeneProduct O O O O O O O O O O