Data obtained indicate that the rs2073601 ' A ' allele , responsible for nonsynonymous substitution of leucine to methionine , may have some role in DS in this population .
O O O O O B-SequenceVariant O O O O O O O O O O B-SequenceVariant I-SequenceVariant I-SequenceVariant O O O O O O B-DiseaseOrPhenotypicFeature O O O O