Basic and clinical research has demonstrated that dementia of sporadic Alzheimer 's disease ( sAD ) type is associated with dysfunction of the insulin-receptor ( IR ) system followed by decreased glucose transport via glucose transporter GLUT4 and decreased glucose metabolism in brain cells .
O O O O O O O B-DiseaseOrPhenotypicFeature O O B-DiseaseOrPhenotypicFeature I-DiseaseOrPhenotypicFeature I-DiseaseOrPhenotypicFeature O B-DiseaseOrPhenotypicFeature O O O O O O O O B-GeneOrGeneProduct O B-GeneOrGeneProduct O O O O O B-ChemicalEntity O O B-ChemicalEntity O B-GeneOrGeneProduct O O B-ChemicalEntity O O O O O