The hazard of developing CAD ( 95 % CI ) associated with initial treatment increased by 2.4-fold ( 1.3-4.3 , P=0.004 ) with glibenclamide ; 2-fold ( 0.9-4.6 , P=0.099 ) with glipizide ; 2.9-fold ( 1.6-5.1 , P=0.000 ) with either , and was unchanged with metformin .
O O O O B-DiseaseOrPhenotypicFeature O O O O O O O O O O O O O O O O O O B-ChemicalEntity O O O O O O O O B-ChemicalEntity O O O O O O O O O O O O O O B-ChemicalEntity O