This mutation denoted an amino acid substitution of arginine residue for the proline residue at position 158 of apoE .
O O O O O O O O B-SequenceVariant I-SequenceVariant I-SequenceVariant I-SequenceVariant I-SequenceVariant I-SequenceVariant I-SequenceVariant I-SequenceVariant I-SequenceVariant O B-GeneOrGeneProduct O