Although marked reductions of CB expression have been observed in the brains of mice and humans with Alzheimer disease ( AD ) , it is unknown whether these changes contribute to AD-related dysfunction .
O O O O B-GeneOrGeneProduct O O O O O O O O B-OrganismTaxon O B-OrganismTaxon O B-DiseaseOrPhenotypicFeature I-DiseaseOrPhenotypicFeature O B-DiseaseOrPhenotypicFeature O O O O O O O O O O B-DiseaseOrPhenotypicFeature O O