We have shown that MPNSTs express neuregulin-1 ( NRG-1 ) beta isoforms , which promote Schwann cell migration during development , and NRG-1 alpha isoforms , whose effects on Schwann cells are poorly understood .
O O O O B-DiseaseOrPhenotypicFeature O B-GeneOrGeneProduct I-GeneOrGeneProduct I-GeneOrGeneProduct I-GeneOrGeneProduct I-GeneOrGeneProduct O O O O O O O O O O O B-GeneOrGeneProduct I-GeneOrGeneProduct O O O O O O O O O O O