Administration of graded doses of U-II ( 1-10,000 ng/mouse ) provoked : ( 1 ) a dose-dependent reduction in the number of head dips in the hole-board test ; ( 2 ) a dose-dependent reduction in the number of entries in the white chamber in the black-and-white compartment test , and in the number of entries in the central platform and open arms in the plus-maze test ; and ( 3 ) a dose-dependent increase in the duration of immobility in the forced-swimming test and tail suspension test .
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