DISCUSSION : Epigenetic reprogramming that imparts functional changes in gene expression , the development of cancer stem cells , and immunomodulation are plausible underlying mechanisms by which early-life iAs exposure elicits latent carcinogenic effects .
O O O O O O O O O O O O O O O B-DiseaseOrPhenotypicFeature O O O O O O O O O O O O B-ChemicalEntity O O O B-DiseaseOrPhenotypicFeature O O