Linkage was obtained to 1q31.3 with a maximal LOD score of 5.20 and a mutation found in exon 9 of the CRB1 gene , causing a G1103R substitution at a highly conserved site in the protein .
O O O O O O O O O O O O O O O O O O O O O B-GeneOrGeneProduct O O O O B-SequenceVariant O O O O O O O O O O