In the present investigation four SNPs in two transcription factors , Single minded 2 ( SIM2 ) and V-ets erythroblastosis virus E26 oncogene homolog2 ( ETS2 ) , located in the 21 { st } chromosome were genotyped to understand their role in DS .
O O O O O O O O O O O B-GeneOrGeneProduct I-GeneOrGeneProduct I-GeneOrGeneProduct O B-GeneOrGeneProduct O O B-GeneOrGeneProduct I-GeneOrGeneProduct I-GeneOrGeneProduct I-GeneOrGeneProduct I-GeneOrGeneProduct I-GeneOrGeneProduct O B-GeneOrGeneProduct O O O O O O O O O O O O O O O O O B-DiseaseOrPhenotypicFeature O