In this study , DNA sequencing of the 12 exons of the PCSK9 gene has been performed in 51 Norwegian subjects with a clinical diagnosis of familial hypercholesterolemia where mutations in the low-density lipoprotein receptor gene and mutation R3500Q in the apolipoprotein B-100 gene had been excluded .
O O O O O O O O O O O O B-GeneOrGeneProduct O O O O O O O O O O O O O B-DiseaseOrPhenotypicFeature I-DiseaseOrPhenotypicFeature O O O O B-GeneOrGeneProduct I-GeneOrGeneProduct I-GeneOrGeneProduct O O O B-SequenceVariant O O B-GeneOrGeneProduct I-GeneOrGeneProduct O O O O O