The aim of this study was therefore to investigate the influence of mutations in these innate immune receptor genes ( nucleotide oligomerisation domain ( NOD ) 2/caspase recruitment domain ( CARD ) 15 , NOD1/CARD4 , TUCAN/CARDINAL/CARD8 , Toll-like receptor ( TLR ) 4 , TLR2 , TLR1 and TLR6 ) on the development of antimicrobial and antiglycan antibodies in inflammatory bowel disease ( IBD ) .
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