Because the CNS damage caused by METH and MPTP is highly selective for the DA neuronal system in mouse models of neurotoxicity , we hypothesized that the CX3CR1 plays a role in METH-induced neurotoxicity and microglial activation .
O O B-DiseaseOrPhenotypicFeature I-DiseaseOrPhenotypicFeature O O B-ChemicalEntity O B-ChemicalEntity O O O O O B-ChemicalEntity O O O B-OrganismTaxon O O B-DiseaseOrPhenotypicFeature O O O O O B-GeneOrGeneProduct O O O O B-ChemicalEntity B-DiseaseOrPhenotypicFeature O O O O