In the present study , we describe the proinflammatory effects of bupivacaine on local prostaglandin E2 ( PGE2 ) production and cyclooxygenase ( COX ) gene expression that increases postoperative pain in human subjects .
O O O O O O O O O O O B-ChemicalEntity O O B-GeneOrGeneProduct I-GeneOrGeneProduct O B-GeneOrGeneProduct O O O B-GeneOrGeneProduct O B-GeneOrGeneProduct O O O O O B-DiseaseOrPhenotypicFeature I-DiseaseOrPhenotypicFeature O B-OrganismTaxon O O