Taken together , our results demonstrated that Sag is a Kras ( G12D ) -cooperating oncogene required for Kras ( G12D ) -induced immortalization and transformation , and targeting SAG-SCF E3 ligase may , therefore , have therapeutic value for senescence-based cancer treatment .
O O O O O O O B-GeneOrGeneProduct O O B-GeneOrGeneProduct O B-SequenceVariant O O O O O B-GeneOrGeneProduct O B-SequenceVariant O O O O O O O O B-GeneOrGeneProduct B-GeneOrGeneProduct I-GeneOrGeneProduct O O O O O O O O O B-DiseaseOrPhenotypicFeature O O