CONCLUSIONS : These findings suggest that 521T > C , existing commonly in SLCO1B1 * 5 , * 15 and * 15+C1007G , is the key single nucleotide polymorphism ( SNP ) that determines the functional properties of SLCO1B1 * 5 , * 15 and * 15+C1007G allelic proteins and that decreased activities of these variant proteins are mainly caused by a sorting error produced by this SNP .
O O O O O O B-SequenceVariant I-SequenceVariant I-SequenceVariant O O O O B-GeneOrGeneProduct O O O O O O O I-SequenceVariant O O O O O O O O O O O O O O O O B-GeneOrGeneProduct O O O O O O O I-SequenceVariant O O O O O O O O O O O O O O O O O O O O O O