Hence , while alterations in select amino acid transporters are not associated with development of sepsis-induced Leu resistance , the Leu-stimulated binding of raptor with RagC and the recruitment of mTOR/raptor to the endosome-lysosomal compartment may partially explain the inability of Leu to fully activate mTOR and muscle protein synthesis .
O O O O O O B-GeneOrGeneProduct I-GeneOrGeneProduct I-GeneOrGeneProduct O O O O O O B-DiseaseOrPhenotypicFeature B-ChemicalEntity O O O B-ChemicalEntity O O B-GeneOrGeneProduct O B-GeneOrGeneProduct O O O O I-GeneOrGeneProduct O O O O O O O O O O B-ChemicalEntity O O O B-GeneOrGeneProduct O O O O O