The ED50 values for morphine when given in combination with CNSB002 ( 5 mg/kg ) were less than the maximum nonsedating dose : 0.56 ( 1.55 ) in the carrageenan model and 1.37 ( 1.23 ) in the neuropathy model ( mg/kg ; mean , SEM ) .
O O O O B-ChemicalEntity O O O O O B-ChemicalEntity O O O O O O O O O O O O O O O O O O B-ChemicalEntity O O O O O O O O B-DiseaseOrPhenotypicFeature O O O O O O O O O