Fourth group received a single dose of ZnSO ( 4 ) ( 0.1 micromol/10 microl normal saline , i.c.v ) then BCNU ( 20 mg/kg , i.v , once ) after 24 h. The obtained data revealed that BCNU administration resulted in deterioration of learning and short-term memory ( STM ) , as measured by using radial arm water maze , accompanied with decreased hippocampal glutathione reductase ( GR ) activity and reduced glutathione ( GSH ) content .
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