In spontaneously hypertensive , stroke-prone rats , microinjection of methyldopa into the area of the midline B3 serotonin cell group in the ventral medulla caused a potent hypotension of 30-40 mm Hg , which was maximal 2-3 h after administration and was abolished by the serotonin neurotoxin 5,7-dihydroxytryptamine ( 5,7-DHT ) injected intracerebroventricularly .
O O B-DiseaseOrPhenotypicFeature O B-DiseaseOrPhenotypicFeature B-OrganismTaxon O O O B-ChemicalEntity O O O O O O O B-ChemicalEntity O O O O O O O O O B-DiseaseOrPhenotypicFeature O O O O O O O O O O O O O O O O O B-ChemicalEntity O B-ChemicalEntity O B-ChemicalEntity O O O O