A comparison of individual selective and unselective cyclooxygenase inhibitors suggests substance-specific differences , which may depend on differences in pharmacokinetic parameters or inhibitory potency and may be contributed by prostaglandin-independent effects .
O O O O O O O B-ChemicalEntity I-ChemicalEntity O O O O O O O O O O O O O O O O O O O O B-ChemicalEntity O O