Significantly lower frequency of SIM2 C-G haplotype ( rs2073601-rs2073416 ) was noticed in individuals with DS ( P value =0.01669 ) and their fathers ( P value=0.01185 ) .
O O O O B-GeneOrGeneProduct O O O B-SequenceVariant O O O O O O B-DiseaseOrPhenotypicFeature O O O O O O O O O O O O O