These results demonstrate the critical role of the final 20 amino acids of caveolin-1 in modulating fibroblast proliferation by dampening Smad signaling and suggest that augmented Smad signaling and fibroblast hyperproliferation are contributing factors in the pathogenesis of PAH in patients with caveolin-1 c.474delA mutation .
O O O O O O O O O O O O O B-GeneOrGeneProduct O O O O O O B-GeneOrGeneProduct O O O O O B-GeneOrGeneProduct O O O O O O O O O O O B-DiseaseOrPhenotypicFeature O B-OrganismTaxon O B-GeneOrGeneProduct B-SequenceVariant O O