Thus , temsirolimus reduced tumor burden through associated cytostatic and anti-angiogenic effects.This dual effect of temsirolimus on tumor tissue could contribute to its recently reported efficiency in refractory MCL resistant to conventional chemotherapy .
O O B-ChemicalEntity O B-DiseaseOrPhenotypicFeature O O O O O O O O O O B-ChemicalEntity O B-DiseaseOrPhenotypicFeature O O O O O O O O O O B-DiseaseOrPhenotypicFeature O O O O O