In conclusion , administration of isoproterenol to rats results in primary loss of dystrophin , the most sensitive among the structural proteins that form the DGC that connects the extracellular matrix and the cytoskeleton in cardiomyocyte .
O O O O O B-ChemicalEntity O B-OrganismTaxon O O O O O B-GeneOrGeneProduct O O O O O O O O O O O O O O O O O O O O O O O