The two transversions resulted in the substitution of a stop codon for glutamine at codon 298 ( p.Q298X ) and a missense mutation at codon 358 , tyrosine to histidine ( p.Y358H ) .
O O O O O O O O O B-SequenceVariant I-SequenceVariant I-SequenceVariant I-SequenceVariant I-SequenceVariant I-SequenceVariant I-SequenceVariant O B-SequenceVariant O O O O O O B-SequenceVariant I-SequenceVariant I-SequenceVariant I-SequenceVariant I-SequenceVariant I-SequenceVariant O B-SequenceVariant O O