Recent studies indicate that genetic ablation of mouse uroplakin ( UP ) III gene , which encodes a 47 kD urothelial-specific integral membrane protein forming urothelial plaques , causes VUR and hydronephrosis .
O O O O O O O B-OrganismTaxon B-GeneOrGeneProduct I-GeneOrGeneProduct I-GeneOrGeneProduct I-GeneOrGeneProduct I-GeneOrGeneProduct O O O O O O O O O O O O O O O O B-DiseaseOrPhenotypicFeature O B-DiseaseOrPhenotypicFeature O