RESULTS : The patient 's GR gene had a heterozygotic mutation ( G -- > A ) at nucleotide position 2141 ( exon 8 ) , which resulted in substitution of arginine by glutamine at amino acid position 714 in the ligand-binding domain ( LBD ) of the GR alpha .
O O O B-OrganismTaxon O B-GeneOrGeneProduct O O O O O B-SequenceVariant I-SequenceVariant I-SequenceVariant I-SequenceVariant I-SequenceVariant I-SequenceVariant I-SequenceVariant I-SequenceVariant I-SequenceVariant I-SequenceVariant O O O O O O O O O O B-SequenceVariant I-SequenceVariant I-SequenceVariant I-SequenceVariant I-SequenceVariant I-SequenceVariant I-SequenceVariant I-SequenceVariant O O O O O O O O O B-GeneOrGeneProduct I-GeneOrGeneProduct O