Subcutaneous injection of ISPH ( 200 mg/kg body weight in 1 ml saline ) to rats for 2 consecutive days caused myocardial damage in rat heart , which was determined by the increased activity of serum lactate dehydrogenase ( LDH ) and creatine phosphokinase isoenzymes ( CK-MB ) , increased uric acid level and reduced plasma iron binding capacity .
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