While powerful antiparkinsonian effects had been observed as early as 1951 , the potential of treating fluctuating Parkinson 's disease by subcutaneous administration of apomorphine has only recently become the subject of systematic study .
O O O O O O O O O O O O O O O O O B-DiseaseOrPhenotypicFeature I-DiseaseOrPhenotypicFeature I-DiseaseOrPhenotypicFeature O O O O B-ChemicalEntity O O O O O O O O O O