Finally , we found that Sag deletion inactivates Kras ( G12D ) activity and block the MAPK signaling pathway , together with accumulated p16 , to induce senescence .
O O O O O B-GeneOrGeneProduct O O B-GeneOrGeneProduct O B-SequenceVariant O O O O O B-GeneOrGeneProduct O O O O O O B-GeneOrGeneProduct O O O O O