The assay has been tested in 50 healthy controls , 3 known patients with achondroplasia , and 5 amniotic fluids suspected of having achondroplasia and for whom we had previously determined the genotypes for the c.1138G > A mutation by PCR-RFLP .
O O O O O O O O O O O O B-OrganismTaxon O B-DiseaseOrPhenotypicFeature O O O O O O O O B-DiseaseOrPhenotypicFeature O O O O O O O O O O O B-SequenceVariant I-SequenceVariant I-SequenceVariant O O O O