Hypoxia is a regulatory factor of the IGF system , however the role of the IGF-1 receptor ( IGF-1R ) in hypoxia-induced apoptosis remains unclear .
B-DiseaseOrPhenotypicFeature O O O O O O B-GeneOrGeneProduct O O O O O O O B-GeneOrGeneProduct I-GeneOrGeneProduct O B-GeneOrGeneProduct O O B-DiseaseOrPhenotypicFeature O O O O