CONCLUSION : Such a weak association and the lack of families with simple dominant Mendelian inheritance suggest that missense changes of uroplakin genes can not play a dominant role in causing VUR in humans , although they may be weak risk factors contributing to a complex polygenic disease .
O O O O O O O O O O O O O O O O O O O O O B-GeneOrGeneProduct O O O O O O O O O B-DiseaseOrPhenotypicFeature O B-OrganismTaxon O O O O O O O O O O O O O O O