Our data demonstrate that the dystonia-causing mutations strongly affect hippocalcin cellular functions which suggest a central role for perturbed calcium signalling in DYT2 dystonia .
O O O O O B-DiseaseOrPhenotypicFeature O O O B-GeneOrGeneProduct O O O O O O O O O B-ChemicalEntity O O B-GeneOrGeneProduct B-DiseaseOrPhenotypicFeature O