All these processes for skin cancer development involve stimulation of DNA synthesis , DNA damage and proliferation , inflammation , immunosuppression , epidermal hyperplasia , cell cycle dysregulation , depletion of antioxidant defenses , impairment of signal transduction pathways , induction of cyclooxygenase , increase in prostaglandin synthesis , and induction of ornithine decarboxylase .
O O O O B-DiseaseOrPhenotypicFeature I-DiseaseOrPhenotypicFeature O O O O O O O O O O O O B-DiseaseOrPhenotypicFeature O O O B-DiseaseOrPhenotypicFeature I-DiseaseOrPhenotypicFeature O O O O O O O B-ChemicalEntity O O O O O O O O O O B-GeneOrGeneProduct O O O B-ChemicalEntity O O O O O B-GeneOrGeneProduct I-GeneOrGeneProduct O