This mutation consists of two consecutive substitutions ( 735-6 TG > AT ) that cause two nonsense mutations ( Y245X , G246X ) , inherited in an autosomal dominant fashion , on one parental chromosome .
O O O O O O O O B-SequenceVariant I-SequenceVariant I-SequenceVariant I-SequenceVariant O O O O O O O B-SequenceVariant O B-SequenceVariant O O O O O O O O O O O O O O