During the course of nephrotic syndrome , serum urea concentrations increased significantly faster in sgk1 ( -/- ) mice than in sgk1 ( +/+ ) mice leading to uremia and a reduced median survival in sgk1 ( -/- ) mice ( 29 vs. 40 days in sgk1 ( +/+ ) mice ) .
O O O O B-DiseaseOrPhenotypicFeature I-DiseaseOrPhenotypicFeature O O B-ChemicalEntity O O O O O B-GeneOrGeneProduct O O O B-OrganismTaxon O O B-GeneOrGeneProduct O O O B-OrganismTaxon O O B-DiseaseOrPhenotypicFeature O O O O O O B-GeneOrGeneProduct O O O B-OrganismTaxon O O O O O O B-GeneOrGeneProduct O O O B-OrganismTaxon O O