We hypothesized that Thra1 ( PV/+ ) mice could be used to predict the skeletal outcome of human THRA mutations and determine whether prolonged treatment with a supraphysiological dose of T4 ameliorates the skeletal abnormalities .
O O O B-GeneOrGeneProduct O O O B-OrganismTaxon O O O O O O O O O B-OrganismTaxon B-GeneOrGeneProduct O O O O O O O O O O O B-ChemicalEntity O O B-DiseaseOrPhenotypicFeature I-DiseaseOrPhenotypicFeature O