SSCP followed by DNA sequencing of the kinase domain ( exons 18-21 ) of the EGFR gene revealed mutations in 2 ou of 69 ( 3 % ) glioblastomas in Japan and in 4 of 81 ( 5 % ) glioblastomas in Switzerland .
O O O O O O O O O O O O O O O B-GeneOrGeneProduct O O O O O O O O O O O O B-DiseaseOrPhenotypicFeature O O O O O O O O O O O B-DiseaseOrPhenotypicFeature O O O