In a double-blind 6-week trial , 458 patients with acute schizophrenia were randomly assigned to fixed-dose treatment with asenapine at 5 mg twice daily ( BID ) , asenapine at 10 mg BID , placebo , or haloperidol at 4 mg BID ( to verify assay sensitivity ) .
O O O O O O O B-OrganismTaxon O O B-DiseaseOrPhenotypicFeature O O O O O O O B-ChemicalEntity O O O O O O O O O B-ChemicalEntity O O O O O O O O B-ChemicalEntity O O O O O O O O O O O