Rare mutations in gene PCSK1 , encoding this enzyme , cause childhood obesity and abnormal glucose homeostasis with elevated proinsulin concentrations .
O O O O B-GeneOrGeneProduct O O O O O O O B-DiseaseOrPhenotypicFeature O B-DiseaseOrPhenotypicFeature I-DiseaseOrPhenotypicFeature I-DiseaseOrPhenotypicFeature O O B-ChemicalEntity O O