The full-length puratrophin-1 mRNA had an open reading frame of 3,576 nt , predicted to contain important domains , including the spectrin repeat and the guanine-nucleotide exchange factor ( GEF ) for Rho GTPases , followed by the Dbl-homologous domain , which indicates the role of puratrophin-1 in intracellular signaling and actin dynamics at the Golgi apparatus .
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