id stringlengths 16 65 | title stringlengths 19 278 | text stringlengths 894 136k | keyphrases listlengths 1 34 | prmu listlengths 1 34 |
|---|---|---|---|---|
J_Muscle_Res_Cell_Motil-3-1-2045119 | Conduction velocities in amphibian skeletal muscle fibres exposed to hyperosmotic extracellular solutions
| Early quantitative analyses of conduction velocities in unmyelinated nerve studied in a constantly iso-osmotic volume conductor were extended to an analysis of the effects of varying extracellular osmolarities on conduction velocities of surface membrane action potentials in Rana esculenta skeletal muscle fibres. Previ... | [
"conduction velocity",
"skeletal muscle",
"osmolarity"
] | [
"P",
"P",
"P"
] |
Pediatr_Nephrol-3-1-1794138 | Pathophysiology of focal segmental glomerulosclerosis
| Focal segmental glomerulosclerosis (FSGS) is a major cause of idiopathic steroid-resistant nephrotic syndrome (SRNS) and end-stage kidney disease (ESKD). In recent years, animal models and studies of familial forms of nephrotic syndrome helped elucidate some mechanisms of podocyte injury and disease progression in FSGS... | [
"pathophysiology",
"focal segmental glomerulosclerosis (fsgs)",
"nephrotic syndrome",
"animal models",
"podocyte",
"injury",
"nephrin",
"podocin",
"tubulointerstitial",
"transforming growth factor (tgfβ)"
] | [
"P",
"P",
"P",
"P",
"P",
"P",
"P",
"P",
"P",
"R"
] |
Neurosurg_Rev-2-2-1564192 | Clinical and radiological features related to the growth potential of meningioma
| Clinical and radiological features that help predict the growth potential of meningioma would be beneficial. The purpose of this study is to clarify the characteristics related to proliferating potential using the MIB-1 staining index. We analyzed the relationship of MIB-1 staining indices to characteristics of 342 con... | [
"growth",
"meningioma",
"mib-1"
] | [
"P",
"P",
"P"
] |
Mech_Dev-2-1-2428104 | Polydactyly in the mouse mutant Doublefoot involves altered Gli3 processing and is caused by a large deletion in cis to Indian hedgehog
| The mouse mutant Doublefoot (Dbf) shows preaxial polydactyly with 6–9 triphalangeal digits in all four limbs and additional abnormalities including a broadened skull, hydrocephalus, and a thickened, kinked tail. The autopod undergoes a characteristic expansion between late embryonic day (E) 10.5 and E11.5, following th... | [
"ihh",
"shh",
"limb patterning",
"digit formation"
] | [
"P",
"P",
"P",
"R"
] |
Eur_Radiol-3-1-2077918 | Multi-detector row computed tomography angiography of peripheral arterial disease
| With the introduction of multi-detector row computed tomography (MDCT), scan speed and image quality has improved considerably. Since the longitudinal coverage is no longer a limitation, multi-detector row computed tomography angiography (MDCTA) is increasingly used to depict the peripheral arterial runoff. Hence, it i... | [
"tomography",
"sensitivity and specificity",
"human",
"peripheral vascular diseases",
"radiography",
"x-ray computed methods",
"reproducibility of results"
] | [
"P",
"P",
"U",
"R",
"U",
"R",
"R"
] |
Graefes_Arch_Clin_Exp_Ophthalmol-4-1-2206250 | Ophthalmologists, suicide bombings and getting it right in the emergency department
| Background The number and extent of worldwide suicide attacks has risen sharply in recent years. The objectives of this retrospective study are: to determine the prevalence and outcome of the victims who sustained ocular injury, to describe the activities of ophthalmologists in the setting of an emergency department (E... | [
"terror",
"ocular trauma",
"vitrectomy",
"intra ocular foreign body"
] | [
"P",
"P",
"P",
"M"
] |
Int_J_Biochem_Cell_Biol-2-1-2267855 | Site-directed mutagenesis of Arginine282 suggests how protons and peptides are co-transported by rabbit PepT1
| The mammalian proton-coupled peptide transporter PepT1 is the major route of uptake for dietary nitrogen, as well as the oral absorption of a number of drugs, including β-lactam antibiotics and angiotensin-converting enzyme inhibitors. Here we have used site-directed mutagenesis to investigate further the role of conse... | [
"site-directed mutagenesis",
"slc15a1",
"epithelia",
"membrane transport",
"nutrient absorption",
"protein structure–function"
] | [
"P",
"P",
"U",
"R",
"M",
"M"
] |
Exp_Brain_Res-4-1-2373863 | Intramanual and intermanual transfer of the curvature aftereffect
| The existence and transfer of a haptic curvature aftereffect was investigated to obtain a greater insight into neural representation of shape. The haptic curvature aftereffect is the phenomenon whereby a flat surface is judged concave if the preceding touched stimulus was convex and vice versa. Single fingers were used... | [
"transfer",
"curvature",
"aftereffect",
"touch",
"mechanoreceptor",
"somatosensory",
"tactile"
] | [
"P",
"P",
"P",
"P",
"P",
"P",
"P"
] |
Eur_J_Appl_Physiol-3-1-1914221 | Physical fitness, fatigue, and quality of life after liver transplantation
| Fatigue is often experienced after liver transplantation. The aims of this cross-sectional study were to assess physical fitness (cardiorespiratory fitness, neuromuscular fitness, body composition) in liver transplant recipients and to explore whether physical fitness is related to severity of fatigue. In addition, we ... | [
"fatigue",
"liver transplantation",
"body composition",
"peak oxygen uptake",
"isokinetic muscle strength"
] | [
"P",
"P",
"P",
"P",
"P"
] |
Clin_Rev_Allergy_Immunol-4-1-2243253 | Anti-CCP2 Antibodies: An Overview and Perspective of the Diagnostic Abilities of this Serological Marker for Early Rheumatoid Arthritis
| The literature of the last 4 years confirms that the anti-CCP2 test is a very useful marker for the early and specific diagnosis of rheumatoid arthritis (RA). The anti-CCP2 test is very specific for RA (95–99%) and has sensitivity comparable to that of the rheumatoid factor (70–75%). The antibodies can be detected very... | [
"ccp2 test",
"rheumatoid factor",
"autoantibodies",
"anti-cyclic citrullinated peptide"
] | [
"P",
"P",
"P",
"P"
] |
Histochem_Cell_Biol-3-1-2137947 | Nucleolus: the fascinating nuclear body
| Nucleoli are the prominent contrasted structures of the cell nucleus. In the nucleolus, ribosomal RNAs are synthesized, processed and assembled with ribosomal proteins. RNA polymerase I synthesizes the ribosomal RNAs and this activity is cell cycle regulated. The nucleolus reveals the functional organization of the nuc... | [
"nucleolus",
"assembly",
"virus",
"cancer",
"dynamics",
"nucleolar structure",
"pnb",
"cell cycle control"
] | [
"P",
"P",
"P",
"P",
"P",
"P",
"P",
"R"
] |
Calcif_Tissue_Int-3-1-1914229 | Use of β-Blockers and the Risk of Hip/Femur Fracture in the United Kingdom and The Netherlands
| Data from in vivo studies have indicated a role for β-blockers in the prevention of bone loss. Some epidemiological studies have found protective effects of β-blockers on fracture risk. However, there is limited information on the association with cumulative dose and type of β-blockers used. We conducted two case-contr... | [
"β-blocker",
"fracture",
"epidemiology",
"case-control",
"osteoporosis"
] | [
"P",
"P",
"P",
"P",
"P"
] |
Purinergic_Signal-4-2-2377322 | A case of serendipity*
| An account is given of how a sensitive bioassay system for measurement of the neurotransmitter acetylcholine serendipitously led to the identification of adenosine triphosphate (ATP) released in vitro from active skeletal muscle. Subsequent application of the identification procedures to exercising human muscle in vivo... | [
"serendipity",
"hypoxia",
"atp release from cells",
"extracellular atp",
"exercise hyperemia"
] | [
"P",
"P",
"P",
"P",
"R"
] |
Biogerontology-4-1-2174522 | Energy metabolism, altered proteins, sirtuins and ageing: converging mechanisms?
| The predominant molecular symptom of ageing is the accumulation of altered gene products. Nutritional studies show that ageing in animals can be significantly influenced by dietary restriction. Genetics has revealed that ageing may be controlled by changes in intracellular NAD/NADH ratio regulating sirtuin activity. Ph... | [
"altered proteins",
"ageing",
"dietary restriction",
"nad",
"nadh",
"methylglyoxal",
"glycolysis",
"deacetylases"
] | [
"P",
"P",
"P",
"P",
"P",
"P",
"P",
"P"
] |
Behav_Genet-4-1-2257998 | Power Calculations Using Exact Data Simulation: A Useful Tool for Genetic Study Designs
| Statistical power calculations constitute an essential first step in the planning of scientific studies. If sufficient summary statistics are available, power calculations are in principle straightforward and computationally light. In designs, which comprise distinct groups (e.g., MZ & DZ twins), sufficient statistics ... | [
"power",
"simulation"
] | [
"P",
"P"
] |
Photosynth_Res-3-1-1779625 | A re-investigation of the path of carbon in photosynthesis utilizing GC/MS methodology. Unequivocal verification of the participation of octulose phosphates in the pathway
| A GC/EIMS/SIM methodology has been developed to re-examine the path of carbon in photosynthesis. Exposing isolated spinach chloroplasts to 13CO2 on a solid support for a defined period followed by quenching and work-up provided a mixture of labelled sugar phosphates. After enzymatic dephosphorylation and derivatization... | [
"chloroplasts",
"selected ion monitoring",
"mox-tms derivatives",
"octulose phosphate shunt",
"13c-enriched sugar phosphates",
"13co2 incorporation",
"gas chromatography–mass spectrometry",
"modified calvin cycle"
] | [
"P",
"P",
"P",
"P",
"M",
"R",
"M",
"R"
] |
Clin_Oral_Investig-4-1-2238781 | Is diagnosing exposed dentine a suitable tool for grading erosive loss?
| Quantifying tooth wear in general and erosion in particular mostly is made by distinguishing between lesions restricted to enamel and lesions reaching the underlying dentine. Various scores for grading have been used, but in all systems, higher scores are given in cases of exposed dentine, thus, indicating a more sever... | [
"dentine",
"tooth wear",
"tooth erosion"
] | [
"P",
"P",
"P"
] |
J_Abnorm_Child_Psychol-4-1-2268722 | Hot and Cool Forms of Inhibitory Control and Externalizing Behavior in Children of Mothers who Smoked during Pregnancy: An Exploratory Study
| This study examined whether children exposed to prenatal smoking show deficits in “hot” and/or “cool” executive functioning (EF). Hot EF is involved in regulation of affect and motivation, whereas cool EF is involved in handling abstract, decontextualized problems. Forty 7 to 9-year-old children (15 exposed to prenatal... | [
"inhibitory control",
"prenatal smoking",
"conduct problems",
"hyperactivity",
"hot and cool executive functioning"
] | [
"P",
"P",
"P",
"P",
"P"
] |
Eur_J_Health_Econ-_-_-1388085 | The “Health Benefit Basket” in The Netherlands
| This contribution describes the entitlements in Dutch health care and explores how these entitlements are determined and to whom they apply. The focus is on services of curative care. No comprehensive positive or negative list of individual services is included in formal laws. Instead, the legislation states only what ... | [
"the netherlands",
"health benefit plans",
"health services",
"health priorities",
"national health programs"
] | [
"P",
"R",
"R",
"M",
"R"
] |
Pediatr_Nephrol-4-1-2214827 | Hypertension in children with chronic kidney disease: pathophysiology and management
| Arterial hypertension is very common in children with all stages of chronic kidney disease (CKD). While fluid overload and activation of the renin–angiotensin system have long been recognized as crucial pathophysiological pathways, sympathetic hyperactivation, endothelial dysfunction and chronic hyperparathyroidism hav... | [
"hypertension",
"children",
"chronic kidney disease",
"pathophysiology",
"life-style changes",
"antihypertension therapy"
] | [
"P",
"P",
"P",
"P",
"P",
"P"
] |
Immunol_Lett-2-1-2430030 | Murine neutrophils present Class II restricted antigen
| Neutrophils were originally described as short lived, terminally differentiated phagocytes that contribute only to the innate immune response. Recent evidence of neutrophil cytokine production and expression of numerous cell surface proteins has suggested that neutrophils are likely to influence adaptive responses and ... | [
"murine",
"neutrophil",
"antigen presentation"
] | [
"P",
"P",
"P"
] |
Eur_J_Clin_Pharmacol-3-1-2039832 | Evaluation of limited sampling strategies for tacrolimus
| Objective In literature, a great diversity of limited sampling strategies (LSS) have been recommended for tacrolimus monitoring, however proper validation of these strategies to accurately predict the area under the time concentration curve (AUC0–12) is limited. The aim of this study was to determine whether these LSS ... | [
"limited sampling strategy",
"tacrolimus",
"auc0–12",
"trough level"
] | [
"P",
"P",
"P",
"P"
] |
Appl_Microbiol_Biotechnol-3-1-1914294 | Functional analysis of genes involved in the biosynthesis of isoprene in Bacillus subtilis
| In comparison to other bacteria Bacillus subtilis emits the volatile compound isoprene in high concentrations. Isoprene is the smallest representative of the natural product group of terpenoids. A search in the genome of B. subtilis resulted in a set of genes with yet unknown function, but putatively involved in the me... | [
"isoprene",
"bacillus subtilis",
"terpenoid",
"mep pathway",
"methylerythritol phosphate pathway",
"gas chromatography"
] | [
"P",
"P",
"P",
"P",
"R",
"M"
] |
Eur_J_Nucl_Med_Mol_Imaging-3-1-2121116 | Left ventricular dyssynchrony assessed by two three-dimensional imaging modalities: phase analysis of gated myocardial perfusion SPECT and tri-plane tissue Doppler imaging
| Purpose To compare left ventricular (LV) dyssynchrony assessment by phase analysis from gated myocardial perfusion SPECT (GMPS) with LV dyssynchrony assessment by tri-plane tissue Doppler imaging (TDI). Baseline LV dyssynchrony assessed with standard deviation (SD) of time-to-peak systolic velocity of 12 LV segments (T... | [
"lv dyssynchrony",
"tdi",
"heart failure",
"nuclear imaging",
"gated spect"
] | [
"P",
"P",
"P",
"P",
"R"
] |
Neuropsychol_Rev-3-1-2039835 | Motor-Skill Learning in Alzheimer’s Disease: A Review with an Eye to the Clinical Practice
| Since elderly people suffering from dementia want to go on living independently for as long as possible, they need to be able to maintain familiar and learn new practical skills. Although explicit or declarative learning methods are mostly used to train new skills, it is hypothesized that implicit or procedural techniq... | [
"motor-skill learning",
"alzheimer’s disease",
"rehabilitation",
"non-pharmacological interventions",
"procedural learning",
"implicit learning"
] | [
"P",
"P",
"P",
"P",
"P",
"P"
] |
Mol_Immunol-1-5-2080686 | C1q deficiency promotes the production of transgenic-derived IgM and IgG3 autoantibodies in anti-DNA knock-in transgenic mice
| C1q-deficient mice have been shown to develop a lupus-like disease and to display an impaired clearance of apoptotic cells that are enriched in lupus autoantigens. However, the role of C1q in the regulation of autoreactive B cells remains debatable. To explore this we crossed MRL/Mp C1q-deficient mice with knock-in tra... | [
"transgenic",
"b cells",
"complement",
"autoimmunity",
"ab, antibody",
"aeu, arbitrary elisa units",
"fo, follicular",
"hel, hen egg lysozyme",
"mz, marginal zone",
"tg, transgenic",
"sle, systematic lupus erythematosus",
"rodent"
] | [
"P",
"P",
"P",
"P",
"R",
"R",
"R",
"R",
"R",
"R",
"R",
"U"
] |
Ulster_Med_J-76-3-2075581 | The use of mechanical bowel preparation in elective colorectal surgery
| Background Mechanical bowel preparation (MBP) prior to elective colorectal surgery has been in use for many years. It is considered important in preventing post-operative infectious complications after colorectal surgery. The evidence to support these claims is lacking within the medical literature and yet this still r... | [
"mechanical bowel preparation",
"colorectal surgery"
] | [
"P",
"P"
] |
Qual_Life_Res-3-1-2039860 | Demographic characteristics and quality of life of patients with unexplained complaints: a descriptive study in general practice
| Objective About 13% of GPs’ consultations involve unexplained complaints (UCs). These complaints can progress to chronic conditions like medically unexplained symptoms, chronic functional symptoms or somatoform disorders. Little is known about the demographic characteristics and quality of life of patients with early s... | [
"quality of life",
"unexplained complaints",
"descriptive study",
"fatigue",
"family practice"
] | [
"P",
"P",
"P",
"P",
"M"
] |
Sleep_Breath-4-1-2276561 | Low intense physical exercise in normobaric hypoxia leads to more weight loss in obese people than low intense physical exercise in normobaric sham hypoxia
| Training in mild to moderate hypoxia (14–17% O2 in breathing air) and extended resting in moderate hypoxia (9–13% O2) have been shown to have effects in animals and humans on lipid and glucose metabolism, appetite loss, and, in part, on body weight. The causality for these effects is not yet known in detail, and the av... | [
"physical exercise",
"normobaric hypoxia",
"weight loss"
] | [
"P",
"P",
"P"
] |
Biotechnol_Lett-3-1-2151841 | Engineering eukaryotic protein factories
| The biopharmaceuticals market is currently outperforming the pharmaceuticals market and is now valued at US$ 48 billion with an average annual growth of 19%. Behind this success is a 100-fold increase in productivities of eukaryotic expression systems. However, the productivity per cell has remained unchanged for more ... | [
"protein folding",
"molecular chaperone",
"unfolded protein response",
"endoplasmic reticulum associated protein degradation",
"heterologous protein production"
] | [
"P",
"P",
"P",
"R",
"R"
] |
Pharm_World_Sci-4-1-2253652 | Minimising treatment-associated risks in systemic cancer therapy
| Aim of the review To review the consequences of drug-related problems (DRP) in systemic cancer therapy and identify specific contributions of the pharmacist to minimise treatment-associated risks. Method Searches in PubMed, Embase and the Cochrane Library were conducted. Bibliographies of retrieved articles were examin... | [
"cancer",
"drug-related problems",
"medication errors",
"oncology",
"pharmaceutical care",
"chemotherapy"
] | [
"P",
"P",
"P",
"P",
"P",
"P"
] |
Arch_Dermatol_Res-3-1-1910890 | German evidence-based guidelines for the treatment of Psoriasis vulgaris (short version)
| Psoriasis vulgaris is a common and chronic inflammatory skin disease which has the potential to significantly reduce the quality of life in severely affected patients. The incidence of psoriasis in Western industrialized countries ranges from 1.5 to 2%. Despite the large variety of treatment options available, patient ... | [
"evidence-based guidelines",
"treatment",
"psoriasis vulgaris"
] | [
"P",
"P",
"P"
] |
Support_Care_Cancer-3-1-2092408 | Testicular cancer: a longitudinal pilot study on stress response symptoms and quality of life in couples before and after chemotherapy
| Goals of work The current study was designed to longitudinally examine stress response symptoms (SRS) and quality of life (QoL) in couples confronted with disseminated testicular cancer. The objectives were to examine couples’ patterns of adjustment over time and possible differences in adjustment between the patient a... | [
"testicular cancer",
"stress response symptoms",
"quality of life",
"chemotherapy",
"partners"
] | [
"P",
"P",
"P",
"P",
"P"
] |
Knee_Surg_Sports_Traumatol_Arthrosc-4-1-2413121 | Effects of biophysical stimulation in patients undergoing arthroscopic reconstruction of anterior cruciate ligament: prospective, randomized and double blind study
| Pre-clinical studies have shown that treatment by pulsed electromagnetic fields (PEMFs) can limit the catabolic effects of pro-inflammatory cytokines on articular cartilage and favour the anabolic activity of the chondrocytes. Anterior cruciate ligament (ACL) reconstruction is usually performed by arthroscopic procedur... | [
"anterior cruciate ligament",
"pulsed electromagnetic fields",
"joint preservation",
"chondroprotection",
"biophysical stimuli"
] | [
"P",
"P",
"P",
"P",
"M"
] |
Int_J_Hematol-4-1-2330061 | Identification of genes potentially involved in supporting hematopoietic stem cell activity of stromal cell line MC3T3-G2/PA6
| Although coculture of hematopoietic stem cells (HSCs) with stromal cells is a useful system to study hematopoiesis in the niche, little is known regarding the precise cellular and molecular mechanisms of maintaining HSCs through cell–cell interactions. The murine preadipose stromal cell line MC3T3-G2/PA6 (PA6) has been... | [
"hematopoietic stem cells",
"stromal cells",
"mc3t3-g2/pa6",
"coculture",
"microarray"
] | [
"P",
"P",
"P",
"P",
"P"
] |
Breast_Cancer_Res_Treat-3-1-2137942 | Stromal mast cells in invasive breast cancer are a marker of favourable prognosis: a study of 4,444 cases
| Purpose We have previously demonstrated in a pilot study of 348 invasive breast cancers that mast cell (MC) infiltrates within primary breast cancers are associated with a good prognosis. Our aim was to verify this finding in a larger cohort of invasive breast cancer patients and examine the relationship between the pr... | [
"stroma",
"mast cells",
"breast cancer",
"inflammatory infiltrate"
] | [
"P",
"P",
"P",
"R"
] |
Immunogenetics-3-1-1914236 | The SPINK gene family and celiac disease susceptibility
| The gene family of serine protease inhibitors of the Kazal type (SPINK) are functional and positional candidate genes for celiac disease (CD). Our aim was to assess the gut mucosal gene expression and genetic association of SPINK1, -2, -4, and -5 in the Dutch CD population. Gene expression was determined for all four S... | [
"spink genes",
"celiac disease",
"genetic association",
"quantitative reverse-transcription polymerase chain reaction"
] | [
"P",
"P",
"P",
"P"
] |
Appl_Psychophysiol_Biofeedback-4-1-2259255 | EEG Biofeedback as a Treatment for Substance Use Disorders: Review, Rating of Efficacy, and Recommendations for Further Research
| Electroencephalographic (EEG) biofeedback has been employed in substance use disorder (SUD) over the last three decades. The SUD is a complex series of disorders with frequent comorbidities and EEG abnormalities of several types. EEG biofeedback has been employed in conjunction with other therapies and may be useful in... | [
"eeg biofeedback",
"substance use disorder",
"neurofeedback",
"alcoholism",
"neurotherapy",
"erp",
"quantitative eeg",
"cognitive-behavioral treatment"
] | [
"P",
"P",
"P",
"P",
"P",
"P",
"P",
"R"
] |
Psychopharmacologia-4-1-2362139 | Expression of amphetamine sensitization is associated with recruitment of a reactive neuronal population in the nucleus accumbens core
| Rationale Repeated exposure to psychostimulant drugs causes a long-lasting increase in the psychomotor and reinforcing effects of these drugs and an array of neuroadaptations. One such alteration is a hypersensitivity of striatal activity such that a low dose of amphetamine in sensitized animals produces dorsal striata... | [
"stereotypy",
"behavioral sensitization",
"striatum",
"prefrontal cortex",
"locomotion",
"immediate-early gene"
] | [
"P",
"P",
"P",
"P",
"P",
"P"
] |
Eur_J_Epidemiol-4-1-2226058 | Apolipoprotein E gene is related to mortality only in normal weight individuals: The Rotterdam study
| Objective To investigate the relationship between the apolipoprotein E (APOE) gene and the risk of mortality in normal weight, overweight and obese individuals. Methods and Results In a population-based study of 7,983 individuals aged 55 years and older, we compared the risks of all-cause and coronary heart disease (CH... | [
"apoe",
"mortality",
"bmi",
"cholesterol",
"chd mortality"
] | [
"P",
"P",
"P",
"P",
"P"
] |
Dev_Genes_Evol-3-1-1784541 | Free-living flatworms under the knife: past and present
| Traditionally, regeneration research has been closely tied to flatworm research, as flatworms (Plathelminthes) were among the first animals where the phenomenon of regeneration was discovered. Since then, the main focus of flatworm regeneration research was on triclads, for which various phenomena were observed and a n... | [
"rhabditophora",
"planarian",
"catenulida",
"acoela",
"platyhelminthes"
] | [
"P",
"P",
"P",
"P",
"U"
] |
Eur_J_Nucl_Med_Mol_Imaging-3-1-1998890 | Treatment of patients with gastro-entero-pancreatic (GEP) tumours with the novel radiolabelled somatostatin analogue [177Lu-DOTA0,Tyr3]octreotate
| Medical treatment and chemotherapy are seldom successful in achieving objective tumour reduction in patients with metastatic neuroendocrine tumours. Treatment with the radiolabelled somatostatin analogue [90Y-DOTA0,Tyr3]octreotide may result in partial remissions in 10–25% of patients. The newer analogue [DOTA0,Tyr3]oc... | [
"octreotate",
"somatostatin receptor",
"gep tumours",
"radionuclide therapy",
"lutetium-177"
] | [
"P",
"P",
"P",
"R",
"U"
] |
Glycoconj_J-4-1-2234449 | Characterization of anticoagulant heparinoids by immunoprofiling
| Heparinoids are used in the clinic as anticoagulants. A specific pentasaccharide in heparinoids activates antithrombin III, resulting in inactivation of factor Xa and–when additional saccharides are present–inactivation of factor IIa. Structural and functional analysis of the heterogeneous heparinoids generally require... | [
"anticoagulation",
"heparinoid",
"immunoprofiling",
"antibody",
"heparin-induced thrombocytopenia"
] | [
"P",
"P",
"P",
"P",
"P"
] |
Ann_Hematol-4-1-2413090 | Cytogenetic features in myelodysplastic syndromes
| Myelodysplastic syndromes (MDS) comprise a group of bone marrow diseases characterized by profound heterogeneity in morphologic presentation, clinical course, and cytogenetic features. Roughly 50% of patients display clonal chromosome abnormalities. In several multicentric studies, the karyotype turned out to be one of... | [
"cytogenetics",
"mds",
"karyotype",
"prognosis",
"monosomy 7",
"complex abnormalities",
"5q−"
] | [
"P",
"P",
"P",
"P",
"P",
"P",
"P"
] |
Ann_Surg_Oncol-4-1-2234441 | A Novel Function of the Receptor for Advanced Glycation End-Products (RAGE) in Association with Tumorigenesis and Tumor Differentiation of HCC
| Background The expression of the receptor for advanced glycation end products (RAGE) has an impact on the mechanisms giving rise to characteristic features of various cancer cells. The purpose of this study was to elucidate the clinicopathological relevance of the level of RAGE expression in patients with hepatocellula... | [
"receptor for advanced glycation end-products ( rage )",
"hepatocellular carcinoma ( hcc )",
"immunohistochemistry",
"hypoxia-reverse-transcription polymerase chain reaction ( rt-pcr )"
] | [
"P",
"P",
"P",
"M"
] |
Qual_Life_Res-3-1-2039846 | Choosing between measures: comparison of EQ-5D, HUI2 and HUI3 in persons with hearing complaints
| Objectives To generate insight into the differences between utility measures EuroQol 5D (EQ-5D), Health Utilities Index Mark II (HUI2) and Mark III (HUI3) and their impact on the incremental cost-effectiveness ratio (ICER) for hearing aid fitting
Introduction
Hearing loss affects the ability to exchange information and... | [
"hearing loss",
"questionnaires",
"costs and cost analysis",
"quality-adjusted life years",
"outcome assessment (health care)"
] | [
"P",
"P",
"R",
"M",
"M"
] |
Eur_J_Health_Econ-_-_-1388079 | The “Health Benefit Basket” in Denmark
| Until 2007, when the new legislation on health care becomes effective, the right to receive free health care services in Denmark, or “health benefits,” are described in a comprehensive set of legislation, including laws, executive orders and legal guidelines. This contribution provides an overview of the current main l... | [
"denmark",
"health services",
"health benefit plans",
"health priorities",
"national health programs"
] | [
"P",
"P",
"R",
"R",
"R"
] |
J_Comput_Aided_Mol_Des-4-1-2270916 | How to do an evaluation: pitfalls and traps
| The recent literature is replete with papers evaluating computational tools (often those operating on 3D structures) for their performance in a certain set of tasks. Most commonly these papers compare a number of docking tools for their performance in cognate re-docking (pose prediction) and/or virtual screening. Relat... | [
"pose prediction",
"virtual screening",
"coordinate error",
"property bias",
"software evaluation"
] | [
"P",
"P",
"P",
"P",
"R"
] |
Childs_Nerv_Syst-4-1-2413122 | Secondary meningioma in a long-term survivor of atypical teratoid/rhabdoid tumour with a germline INI1 mutation
| Objective We report on a patient who developed a meningioma more than two decades after removal at a young age of an atypical teratoid/rhabdoid tumour (AT/RT), which was due to a germline INI1 mutation, and radio- and chemotherapy.
Introduction
We previously reported on a family in which four cousins developed an atypi... | [
"meningioma",
"atypical teratoid/rhabdoid tumour",
"ini1",
"radiation therapy",
"genetic predisposition"
] | [
"P",
"P",
"P",
"P",
"M"
] |
Diabetologia-4-1-2362134 | Increased osteoclastic activity in acute Charcot’s osteoarthopathy: the role of receptor activator of nuclear factor-kappaB ligand
| Aims/hypothesis Our aims were to compare osteoclastic activity between patients with acute Charcot’s osteoarthropathy and diabetic and healthy controls, and to determine the effect of the receptor activator of nuclear factor-kappaB ligand (RANKL) and its decoy receptor osteoprotegerin (OPG).
Introduction
Although Charc... | [
"osteoclasts",
"charcot’s osteoarthropathy",
"rankl",
"opg",
"resorption",
"osteolysis"
] | [
"P",
"P",
"P",
"P",
"P",
"P"
] |
J_Chem_Ecol-3-1-1915630 | Jasmonic Acid-Induced Changes in Brassica oleracea Affect Oviposition Preference of Two Specialist Herbivores
| Jasmonic acid (JA) is a key hormone involved in plant defense responses. The effect of JA treatment of cabbage plants on their acceptability for oviposition by two species of cabbage white butterflies, Pieris rapae and P. brassicae, was investigated. Both butterfly species laid fewer eggs on leaves of JA-treated plants... | [
"cabbage",
"pieris rapae",
"glucosinolates",
"pieris brassicae",
"performance",
"octadecanoid pathway",
"host plant selection"
] | [
"P",
"P",
"P",
"P",
"P",
"P",
"P"
] |
Pediatr_Nephrol-4-1-2335295 | Improved renal survival in Japanese children with IgA nephropathy
| Since the beginning of the 1990s, Japanese medical practitioners have extensively prescribed angiotensin-converting enzyme (ACE) inhibitors for children with mild IgA nephropathy (IgA-N) and steriods for those with severe IgA-N. We have performed a retrospective cohort study to clarify whether the long-term outcome has... | [
"corticosteroid",
"mesangial proliferation",
"proteinuria",
"ace inhibitors",
"immunosuppressive drug"
] | [
"P",
"P",
"P",
"R",
"M"
] |
Bioinformation-2-2-2174421 | DoD2007: 1082 molecular biology databases
| Molecular biology databases are an integral part of biological research. To date, many databases were established with varied options to access associated biological data. Depending on the data being annotated, some are architecturally similar while others are specialized. In order to provide a partial solution to data... | [
"molecular biology",
"database",
"data integration",
"javascript"
] | [
"P",
"P",
"P",
"P"
] |
Eur_J_Epidemiol-3-1-2071967 | The Rotterdam Study: objectives and design update
| The Rotterdam Study is a prospective cohort study ongoing since 1990 in the city of Rotterdam in the Netherlands. The study targets cardiovascular, neurological, ophthalmological and endocrine diseases. As of 2008 about 15,000 subjects aged 45 years or over comprise the Rotterdam Study cohort. The findings of the Rotte... | [
"cohort study",
"heart failure",
"stroke",
"parkinson disease",
"alzheimer disease",
"dementia",
"macular degeneration",
"glaucoma",
"diabetes",
"osteoporosis",
"pharmaco-epidemiology",
"myocardial infarction",
"genome wide analysis"
] | [
"P",
"P",
"P",
"P",
"P",
"P",
"P",
"P",
"P",
"P",
"P",
"P",
"P"
] |
Intensive_Care_Med-2-2-1315315 | SAPS 3—From evaluation of the patient to evaluation of the intensive care unit. Part 2: Development of a prognostic model for hospital mortality at ICU admission
| Objective To develop a model to assess severity of illness and predict vital status at hospital discharge based on ICU admission data.
Introduction
One of the crucial steps in the evaluation of risk-adjusted outcomes is the choice of the reference database for estimating adequate reference lines for the analyzed variab... | [
"intensive care unit",
"hospital mortality",
"severity of illness",
"icu mortality",
"risk adjustment"
] | [
"P",
"P",
"P",
"R",
"M"
] |
Matern_Child_Health_J-2-2-1592155 | Preconception Care in International Settings
| Objectives: This literature review briefly describes international programs, policies, and activities related to preconception care and resulting pregnancy outcomes. Methods: Electronic databases were searched and findings supplemented with secondary references cited in the original articles as well as textbook chapter... | [
"preconception care",
"international health",
"reproductive health"
] | [
"P",
"P",
"P"
] |
Clin_Exp_Metastasis-4-1-2413104 | Serum proteome analysis for profiling protein markers associated with carcinogenesis and lymph node metastasis in nasopharyngeal carcinoma
| Nasopharyngeal carcinoma (NPC), one of the most common cancers in population with Chinese or Asian progeny, poses a serious health problem for southern China. It is unfortunate that most NPC victims have had lymph node metastasis (LNM) when first diagnosed. We believe that the 2D based serum proteome analysis can be us... | [
"serum proteome",
"carcinogenesis",
"lymph node metastasis",
"nasopharyngeal carcinoma"
] | [
"P",
"P",
"P",
"P"
] |
Arch_Orthop_Trauma_Surg-3-1-2111040 | Trochanteric fractures in the elderly: the influence of primary hip arthroplasty on 1-year mortality
| Introduction The aim of the study was to compare the mortality risk and complication rate after operative treatment of pertrochanteric fractures with primary arthroplasty, dynamic hip screw (DHS) or proximal femoral nail (PFN).
Introduction
While relative consensus exists about the treatment of femoral neck fractures f... | [
"mortality risk",
"trochanteric femoral fractures",
"total hip replacement"
] | [
"P",
"P",
"P"
] |
Breast_Cancer_Res_Treat-3-1-2045691 | Differential effects of tamoxifen and anastrozole on optic cup size in breast cancer survivors
| Introduction The main purpose of this study was to determine whether the optic cups of tamoxifen users and anastrozole users differ in size, with the cups of the tamoxifen users being smaller.
Introduction
Selective estrogen receptor modulators (SERMS) and aromatase inhibitors are the two major classes of medications u... | [
"tamoxifen",
"anastrozole",
"optic cup",
"breast cancer",
"adjuvant endocrine therapy",
"eye",
"optic nerve head"
] | [
"P",
"P",
"P",
"P",
"P",
"P",
"P"
] |
J_Gastrointest_Surg-3-1-1915638 | Long-term Results of a Primary End-to-end Anastomosis in Peroperative Detected Bile Duct Injury
| The management of a bile duct injury detected during laparoscopic cholecystectomy is still under discussion. An end-to-end anastomosis (with or without T-tube drainage) in peroperative detected bile duct injury has been reported to be associated with stricture formation of the anastomosis area and recurrent jaundice. B... | [
"end-to-end anastomosis",
"bile duct injury",
"cholecystectomy"
] | [
"P",
"P",
"P"
] |
Osteoporos_Int-4-1-2267483 | Loss of treatment benefit due to low compliance with bisphosphonate therapy
| Summary Among 8,822 new female bisphosphonate users, non-compliant bisphosphonate use was associated with a 45% increased risk of osteoporotic fracture compared to compliant use (MPR ≥80%). Classifying compliance into five categories, fracture risk gradually increased with poorer compliance. These results emphasize the... | [
"benefit",
"bisphosphonates",
"non-compliance",
"fracture",
"osteoporosis"
] | [
"P",
"P",
"P",
"P",
"P"
] |
Skeletal_Radiol-3-1-2042033 | Whole-body imaging of the musculoskeletal system: the value of MR imaging
| In clinical practice various modalities are used for whole-body imaging of the musculoskeletal system, including radiography, bone scintigraphy, computed tomography, magnetic resonance imaging (MRI), and positron emission tomography-computed tomography (PET-CT). Multislice CT is far more sensitive than radiographs in t... | [
"whole-body",
"imaging",
"musculoskeletal",
"magnetic resonance imaging"
] | [
"P",
"P",
"P",
"P"
] |
Cell_Tissue_Res-3-1-2039796 | Effect of thrombin peptide 508 (TP508) on bone healing during distraction osteogenesis in rabbit tibia
| Thrombin-related peptide 508 (TP508) accelerates bone regeneration during distraction osteogenesis (DO). We have examined the effect of TP508 on bone regeneration during DO by immunolocalization of Runx2 protein, a marker of osteoblast differentiation, and of osteopontin (OPN) and bone sialoprotein (BSP), two late mark... | [
"thrombin peptide",
"distraction osteogenesis",
"bone regeneration",
"runx2",
"osteopontin",
"bone sialoprotein",
"immunohistochemistry",
"rabbit (new zealand white, adult, male)"
] | [
"P",
"P",
"P",
"P",
"P",
"P",
"P",
"R"
] |
J_Med_Internet_Res-7-2-1550646 | A Case Study of a Retracted Systematic Review on Interactive Health Communication Applications: Impact on Media, Scientists, and Patients
| Background In October 2004, a flawed systematic review entitled “Interactive Health Communication Applications for People with Chronic Disease” was published in the Cochrane Library, accompanied by several press releases in which authors warned the public of the negative health consequences of interactive health commun... | [
"patients",
"mass media",
"retraction of publication",
"online systems",
"medical errors",
"editorial policies"
] | [
"P",
"P",
"R",
"R",
"R",
"M"
] |
Virchows_Arch-4-1-2329729 | The significance of lobular neoplasia on needle core biopsy of the breast
| The management of a core biopsy diagnosis of lobular neoplasia is controversial. Detailed radiological–pathological review of 47 patients with cores showing classical lobular neoplasia was performed (patients with pleomorphic lobular carcinoma in situ (LCIS) or associated risk lesions were considered separately). Immed... | [
"lobular neoplasia",
"breast",
"pleomorphic lobular carcinoma in situ",
"lobular carcinoma in situ",
"atypical lobular neoplasia",
"needle biopsy"
] | [
"P",
"P",
"P",
"P",
"R",
"R"
] |
Anal_Bioanal_Chem-3-1-1592252 | Identification of sulfation sites of metabolites and prediction of the compounds’ biological effects
| Characterizing the biological effects of metabolic transformations (or biotransformation) is one of the key steps in developing safe and effective pharmaceuticals. Sulfate conjugation, one of the major phase II biotransformations, is the focus of this study. While this biotransformation typically facilitates excretion ... | [
"sulfation",
"metabolites",
"pharmaceuticals",
"mass spectrometry",
"icp-ms",
"bioanalytical methods",
"biological samples"
] | [
"P",
"P",
"P",
"P",
"U",
"M",
"R"
] |
Anal_Bioanal_Chem-4-1-2270354 | Neutron activation analysis and X-ray Rayleigh and Raman scattering of hair and nail clippings as noninvasive bioindicators for Cu liver status in Labrador Retrievers
| The heritability of chronic hepatitis in the Labrador Retriever is studied with the aim of identifying the related gene mutation. Identification of cases and controls is largely based on instrumental neutron activation analysis (INAA) Cu determination in liver biopsies. The burden for these companion animals may be red... | [
"neutron activation analysis",
"trace elements",
"chemometrics",
"x-ray spectroscopy",
"biological samples"
] | [
"P",
"P",
"P",
"M",
"R"
] |
J_Gastrointest_Surg-3-1-1852374 | Risk of Fecal Diversion in Complicated Perianal Crohn’s Disease
| The purpose of the study was to determine the overall risk of a permanent stoma in patients with complicated perianal Crohn’s disease, and to identify risk factors predicting stoma carriage. A total of 102 consecutive patients presented with the first manifestation of complicated perianal Crohn’s disease in our outpati... | [
"fecal diversion",
"crohn’s disease",
"perianal abscesses",
"fistulas"
] | [
"P",
"P",
"P",
"P"
] |
Plant_Mol_Biol-3-1-1805040 | Genome-wide transcriptional analysis of salinity stressed japonica and indica rice genotypes during panicle initiation stage
| Rice yield is most sensitive to salinity stress imposed during the panicle initiation (PI) stage. In this study, we have focused on physiological and transcriptional responses of four rice genotypes exposed to salinity stress during PI. The genotypes selected included a pair of indicas (IR63731 and IR29) and a pair of ... | [
"rice",
"panicle initiation",
"salt stress",
"microarray"
] | [
"P",
"P",
"P",
"P"
] |
Skeletal_Radiol-4-1-2335296 | Plantar fasciitis and calcaneal spur formation are associated with abductor digiti minimi atrophy on MRI of the foot
| Objective To determine the association of atrophy of the abductor digiti minimi muscle (ADMA), an MRI manifestation of chronic compression of the inferior calcaneal nerve suggesting the clinical diagnosis of Baxter’s neuropathy, with MRI markers of potential etiologies, including calcaneal spur formation, plantar fasci... | [
"plantar fasciitis",
"mri",
"foot",
"muscle atrophy",
"muscle denervation"
] | [
"P",
"P",
"P",
"P",
"R"
] |
Eur_Radiol-2-2-1705470 | New coil concept for endoluminal MR imaging
| Our aim was to conduct a prospective study to evaluate staging accuracy of a new coil concept for endoluminal magnetic resonance imaging (MRI) on ex vivo gastric carcinomas. Twenty-eight consecutive patients referred to surgery with a clinically proven primary gastric malignancy were included. Surgical specimens were e... | [
"coils",
"magnetic resonance imaging",
"stomach neoplasms",
"neoplasm staging",
"experimental study"
] | [
"P",
"P",
"M",
"M",
"M"
] |
Clin_Oral_Investig-4-1-2238791 | How valid are current diagnostic criteria for dental erosion?
| In principle, there is agreement about the clinical diagnostic criteria for dental erosion, basically defined as cupping and grooving of the occlusal/incisal surfaces, shallow defects on smooth surfaces located coronal from the enamel–cementum junction with an intact cervical enamel rim and restorations rising above th... | [
"validity",
"criteria",
"erosion",
"epidemiology",
"diagnosis"
] | [
"P",
"P",
"P",
"P",
"P"
] |
J_Comput_Aided_Mol_Des-4-1-2270923 | What do we know and when do we know it?
| Two essential aspects of virtual screening are considered: experimental design and performance metrics. In the design of any retrospective virtual screen, choices have to be made as to the purpose of the exercise. Is the goal to compare methods? Is the interest in a particular type of target or all targets? Are we simu... | [
"virtual screening",
"metrics",
"statistics",
"auc",
"roc curves"
] | [
"P",
"P",
"P",
"P",
"P"
] |
Ann_Hematol-2-2-1705486 | Lenalidomide in the context of complex karyotype or interrupted treatment: case reviews of del(5q)MDS patients with unexpected responses
| Lenalidomide has particular activity in patients with transfusion-dependent del(5q) myelodysplastic syndromes (MDS), but mechanistic information is limited regarding the relationship between erythroid and cytogenetic responses. We reviewed medical records from three distinct subgroups of del(5q) MDS patients who had un... | [
"lenalidomide",
"transfusion-dependent",
"myelodysplastic syndromes",
"del(5q) mds",
"case studies"
] | [
"P",
"P",
"P",
"P",
"R"
] |
Psychopharmacologia-3-1-2080347 | Lack of evidence for reduced prefrontal cortical serotonin and dopamine efflux after acute tryptophan depletion
| Rationale Acute tryptophan depletion (ATD) is a widely used method to study the role of serotonin (5-HT) in affect and cognition. ATD results in a strong but transient decrease in plasma tryptophan and central 5-HT synthesis and availability. Although its use is widespread, the evidence that the numerous functional eff... | [
"tryptophan",
"serotonin (5-ht)",
"dopamine (da)",
"microdialysis",
"medial prefrontal cortex"
] | [
"P",
"P",
"P",
"P",
"R"
] |
Ann_Biomed_Eng-2-2-1705491 | Bioactive Hydrogel Substrates: Probing Leukocyte Receptor–Ligand Interactions in Parallel Plate Flow Chamber Studies
| The binding of activated integrins on the surface of leukocytes facilitates the adhesion of leukocytes to vascular endothelium during inflammation. Interactions between selectins and their ligands mediate rolling, and are believed to play an important role in leukocyte adhesion, though the minimal recognition motif req... | [
"hydrogel",
"flow chamber",
"leukocyte adhesion",
"poly(ethylene glycol)"
] | [
"P",
"P",
"P",
"P"
] |
Pflugers_Arch-3-1-2137943 | A refined radio-telemetry technique to monitor right ventricle or pulmonary artery pressures in rats: a useful tool in pulmonary hypertension research
| Implantable radio-telemetry methodology, allowing for continuous recording of pulmonary haemodynamics, has previously been used to assess effects of therapy on development and treatment of pulmonary hypertension. In the original procedure, rats were subjected to invasive thoracic surgery, which imposes significant stre... | [
"pulmonary artery",
"diaphragm",
"heart",
"respiration",
"circulation",
"blood pressure",
"cardiac output",
"power output",
"hypertensive rats",
"vascular remodelling"
] | [
"P",
"P",
"P",
"P",
"P",
"P",
"P",
"P",
"R",
"R"
] |
J_Comp_Physiol_A_Neuroethol_Sens_Neural_Behav_Physiol-4-1-2248214 | Far field scattering pattern of differently structured butterfly scales
| The angular and spectral reflectance of single scales of five different butterfly species was measured and related to the scale anatomy. The scales of the pierids Pieris rapae and Delias nigrina scatter white light randomly, in close agreement with Lambert’s cosine law, which can be well understood from the randomly or... | [
"scattering",
"angular reflectance",
"lambertian reflector",
"single butterfly scale",
"structural colour"
] | [
"P",
"P",
"P",
"P",
"R"
] |
BMC_Bioinformatics-4-_-521197 | EasyGene – a prokaryotic gene finder that ranks ORFs by statistical significance
| Background Contrary to other areas of sequence analysis, a measure of statistical significance of a putative gene has not been devised to help in discriminating real genes from the masses of random Open Reading Frames (ORFs) in prokaryotic genomes. Therefore, many genomes have too many short ORFs annotated as genes.
Ba... | [
"statistical significance",
"computational gene finding",
"hidden markov model",
"short open reading frames",
"automated genome annotation"
] | [
"P",
"P",
"P",
"R",
"R"
] |
Hernia-4-1-2231409 | Impact of the mesh fixation technique on operation time in laparoscopic repair of ventral hernias
| Background Fixation of the prosthesis is one of the critical components of laparoscopic repair of ventral and incisional hernia (LRVIH). The impact of the fixation technique used on operative time has never been analyzed. We compared the duration of the operation according to the fixation technique used in a series of ... | [
"hernia",
"umbilical",
"laparoscopy",
"study, time",
"surgical mesh",
"surgical fixation devices"
] | [
"P",
"P",
"U",
"R",
"M",
"M"
] |
Ann_Surg_Oncol-4-1-2266786 | Liver Transplantation for Hepatocellular Carcinoma
| Background Orthotopic liver transplantation (OLT) is the best available option for early hepatocellular carcinoma (HCC), although its application is limited by stringent selection criteria, costs, and deceased donor graft shortage, particularly in Asia, where living donor liver transplant (LDLT) has been developed.
Hep... | [
"transplantation",
"hepatocellular",
"hepatoma"
] | [
"P",
"P",
"U"
] |
Pediatr_Radiol-4-1-2292499 | Sonographic findings in bacterial meningitis in neonates and young infants
| Cranial sonography plays an important role in the initial evaluation of infants with suspected bacterial meningitis and in monitoring for complications of the disease. Echogenic widening of the brain sulci, meningeal thickening and hyperemia suggest the diagnosis in an at-risk population. Sonography can identify the pr... | [
"meningitis",
"doppler",
"children",
"ultrasonography",
"bacterial infections",
"central nervous system infections"
] | [
"P",
"P",
"P",
"U",
"R",
"R"
] |
Vision_Res-2-1-2386851 | Contrast discrimination: Second responses reveal the relationship between the mean and variance of visual signals
| To explain the relationship between first- and second-response accuracies in a detection experiment, Swets, Tanner, and Birdsall [Swets, J., Tanner, W. P., Jr., & Birdsall, T. G. (1961). Decision processes in perception. Psychological Review, 68, 301–340] proposed that the variance of visual signals increased with thei... | [
"contrast",
"discrimination",
"detection",
"threshold",
"uncertainty",
"psychophysics",
"noise"
] | [
"P",
"P",
"P",
"P",
"P",
"P",
"P"
] |
Histochem_Cell_Biol-4-1-2228381 | Protein quality control: the who’s who, the where’s and therapeutic escapes
| In cells the quality of newly synthesized proteins is monitored in regard to proper folding and correct assembly in the early secretory pathway, the cytosol and the nucleoplasm. Proteins recognized as non-native in the ER will be removed and degraded by a process termed ERAD. ERAD of aberrant proteins is accompanied by... | [
"erad",
"protein folding disease",
"glucosidase ii",
"glucosyltransferase",
"edem1",
"endomannosidase",
"chemical chaperones"
] | [
"P",
"P",
"P",
"P",
"P",
"P",
"P"
] |
Pflugers_Arch-3-1-1950587 | Transmural variations in gene expression of stretch-modulated proteins in the rat left ventricle
| The properties of left ventricular cardiac myocytes vary transmurally. This may be related to the gradients of stress and strain experienced in vivo across the ventricular wall. We tested the hypothesis that within the rat left ventricle there are transmural differences in the expression of genes for proteins that are ... | [
"gene expression",
"stretch",
"cardiac myocytes",
"trp channels",
"stretch-activated channel"
] | [
"P",
"P",
"P",
"M",
"M"
] |
Histochem_Cell_Biol-4-1-2413110 | The desmosome and pemphigus
| Desmosomes are patch-like intercellular adhering junctions (“maculae adherentes”), which, in concert with the related adherens junctions, provide the mechanical strength to intercellular adhesion. Therefore, it is not surprising that desmosomes are abundant in tissues subjected to significant mechanical stress such as ... | [
"desmosomes",
"pemphigus",
"autoantibodies",
"desmogleins",
"steric hindrance",
"desmoglein compensation"
] | [
"P",
"P",
"P",
"P",
"P",
"P"
] |
Mol_Immunol-1-5-2075531 | The different effector function capabilities of the seven equine IgG subclasses have implications for vaccine strategies
| Recombinant versions of the seven equine IgG subclasses were expressed in CHO cells. All assembled into intact immunoglobulins stabilised by disulphide bridges, although, reminiscent of human IgG4, a small proportion of equine IgG4 and IgG7 were held together by non-covalent bonds alone. All seven IgGs were N-glycosyla... | [
"igg",
"protein a",
"respiratory burst",
"complement",
"horse",
"reqigg, recombinant equine igg",
"ehv-1, equine herpes virus-1",
"nip, 3-nitro-4-hydroxy-5-iodophenylacetate",
"pbs-t, pbs-tween",
"fcγr, receptor specific for the fc region of igg",
"pbl, peripheral blood leukocyte",
"recombinan... | [
"P",
"P",
"P",
"P",
"P",
"R",
"M",
"M",
"M",
"R",
"R",
"R"
] |
Cogn_Process-4-1-2254470 | Coherence and recurrency: maintenance, control and integration in working memory
| Working memory (WM), including a ‘central executive’, is used to guide behavior by internal goals or intentions. We suggest that WM is best described as a set of three interdependent functions which are implemented in the prefrontal cortex (PFC). These functions are maintenance, control of attention and integration. A ... | [
"maintenance",
"integration",
"working memory",
"prefrontal cortex",
"control of attention",
"synchronization",
"recurrent networks"
] | [
"P",
"P",
"P",
"P",
"P",
"P",
"R"
] |
Eur_Spine_J-2-2-1602195 | Preadolescent presentation of a lumbar chordoma: results of vertebrectomy and fibula strut graft reconstruction at 8 years
| Chordoma is a tumour of notochordal origin which usually involves the sacrum or skull base presenting in adulthood. Chordoma in a mobile spinal segment is infrequent and the authors report an extremely rare presentation of L3 chordoma in a child aged 7 years. Although a benign tumour, mobile segment chordoma is more lo... | [
"chordoma",
"vertebrectomy",
"mobile spinal segment",
"benign tumour",
"fibular strut graft reconstruction"
] | [
"P",
"P",
"P",
"P",
"P"
] |
Eur_J_Clin_Pharmacol-4-1-2254473 | Prior outpatient antibiotic use as predictor for microbial aetiology of community-acquired pneumonia: hospital-based study
| Objective The causative micro-organism in community-acquired pneumonia (CAP) is often difficult to predict. Different studies have examined chronic morbidity and clinical symptoms as predictors for microbial aetiology of pneumonia. The aim of our study was to assess whether prior outpatient antimicrobial treatment is p... | [
"antibiotics",
"aetiology",
"pneumonia",
"diagnosis",
"outcome assessment"
] | [
"P",
"P",
"P",
"P",
"R"
] |
Histochem_Cell_Biol-4-1-2248610 | Retrograde traffic in the biosynthetic-secretory route
| In the biosynthetic-secretory route from the rough endoplasmic reticulum, across the pre-Golgi intermediate compartments, the Golgi apparatus stacks, trans Golgi network, and post-Golgi organelles, anterograde transport is accompanied and counterbalanced by retrograde traffic of both membranes and contents. In the phys... | [
"retrograde traffic",
"er",
"golgi apparatus",
"endocytosis",
"biosynthetic secretory route"
] | [
"P",
"P",
"P",
"P",
"R"
] |
J_Mol_Evol-3-1-1894752 | The Mechanisms of Codon Reassignments in Mitochondrial Genetic Codes
| Many cases of nonstandard genetic codes are known in mitochondrial genomes. We carry out analysis of phylogeny and codon usage of organisms for which the complete mitochondrial genome is available, and we determine the most likely mechanism for codon reassignment in each case. Reassignment events can be classified acco... | [
"codon reassignment",
"mitochondrial genetic codes",
"unassigned codon mechanism",
"ambiguous intermediate mechanism",
"codon disappearance mechanism"
] | [
"P",
"P",
"P",
"P",
"R"
] |
Transgenic_Res-3-1-1829418 | Effects of FVB/NJ and C57Bl/6J strain backgrounds on mammary tumor phenotype in inducible nitric oxide synthase deficient mice
| The ability to genetically manipulate mice has led to rapid progress in our understanding of the roles of different gene products in human disease. Transgenic mice have often been created in the FVB/NJ (FVB) strain due to its high fecundity, while gene-targeted mice have been developed in the 129/SvJ-C57Bl/6J strains d... | [
"fvb/nj",
"c57bl/6j",
"strain",
"mouse",
"breast",
"cancer",
"inos",
"polyomavirus middle t antigen"
] | [
"P",
"P",
"P",
"P",
"P",
"P",
"P",
"M"
] |
Eur_J_Pediatr-4-1-2234440 | Moebius-Poland syndrome and hypogonadotropic hypogonadism
| Case report
A male infant was born at 39 weeks of gestation, with birth weight (3.1 kg) and body length (49 cm) (both 50th percentile). The occipitofrontal circumference was 33 cm (25th percentile). The newborn’s face was inexpressive due to complete facial diplegia, bilateral ophthalmoplegia with impairment of the ver... | [
"hypogonadotropic",
"hypogonadism",
"moebius syndrome",
"poland syndrome"
] | [
"P",
"P",
"P",
"R"
] |
Breast_Cancer_Res_Treat-4-1-2190785 | Impact of a programme of mass mammography screening for breast cancer on socio-economic variation in survival: a population-based study
| Background After a systematic mass mammography breast cancer screening programme was implemented between 1991 and 1996 (attendance 80%), we evaluated its impact on survival according to socioeconomic status (SES).
Introduction
Mammography screening aims at early detection of breast cancer so that adequate treatment wil... | [
"breast cancer",
"survival",
"mass screening",
"socio-economic status"
] | [
"P",
"P",
"P",
"P"
] |
Eur_J_Clin_Pharmacol-3-1-1914266 | Coumarin anticoagulants and co-trimoxazole: avoid the combination rather than manage the interaction
| Objective The objective of our study was to examine the management of the interaction between acenocoumarol or phenprocoumon and several antibiotics by anticoagulation clinics and to compare the consequences of this interaction on users of co-trimoxazole with those for users of other antibiotics.
Introduction
Coumarin-... | [
"coumarins",
"co-trimoxazole",
"acenocoumarol",
"phenprocoumon",
"antibiotics",
"anticoagulation clinic",
"drug interaction"
] | [
"P",
"P",
"P",
"P",
"P",
"P",
"P"
] |
Appl_Microbiol_Biotechnol-3-1-2039825 | Properties, production, and applications of camelid single-domain antibody fragments
| Camelids produce functional antibodies devoid of light chains of which the single N-terminal domain is fully capable of antigen binding. These single-domain antibody fragments (VHHs or Nanobodies®) have several advantages for biotechnological applications. They are well expressed in microorganisms and have a high stabi... | [
"single-domain",
"yeast",
"microbial production",
"glycosylation"
] | [
"P",
"P",
"P",
"P"
] |
J_Headache_Pain-4-1-2245992 | Performances in cerebellar and neuromuscular transmission tests are correlated in migraine with aura
| In previous studies, we described subclinical abnormalities of neuromuscular transmission and cerebellar functions in migraineurs. The aim of this study was to search if these two functions are correlated in the same patient. Thirteen migraineurs [five without aura (MO) and eight with aura (MA)] underwent both stimulat... | [
"migraine",
"genetics",
"neuromuscular junction",
"cerebellum"
] | [
"P",
"P",
"P",
"P"
] |
J_Chem_Ecol-4-1-2266969 | Prey and Non-prey Arthropods Sharing a Host Plant: Effects on Induced Volatile Emission and Predator Attraction
| It is well established that plants infested with a single herbivore species can attract specific natural enemies through the emission of herbivore-induced volatiles. However, it is less clear what happens when plants are simultaneously attacked by more than one species. We analyzed volatile emissions of lima bean and c... | [
"food webs",
"signal transduction",
"gc-ms",
"methyl salicylate",
"indirect defense",
"terpenes",
"tritrophic interactions"
] | [
"P",
"P",
"P",
"P",
"M",
"U",
"M"
] |
Exp_Brain_Res-4-1-2248215 | Attenuation of N2 amplitude of laser-evoked potentials by theta burst stimulation of primary somatosensory cortex
| Theta burst stimulation (TBS) is a special repetitive transcranial magnetic stimulation (rTMS) paradigm, where bursts of low-intensity stimuli are applied in the theta frequency. The aim of this study was to investigate the effect of neuronavigated TBS over primary somatosensory cortex (SI) on laser-evoked potentials (... | [
"laser-evoked potentials",
"primary somatosensory cortex",
"neuronavigation",
"pain",
"theta burst transcranial magnetic stimulation"
] | [
"P",
"P",
"P",
"P",
"R"
] |
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