Datasets:

ClarusC64
/

clinical-interventional-ripple-cross-system-propagation-mapping-v0.1

id stringclasses 10 values	intervention_name stringclasses 9 values	perturbation_profile stringclasses 9 values	primary_system_engaged stringclasses 7 values	baseline_state_snapshot stringclasses 10 values	observed_changes_autonomic stringclasses 9 values	observed_changes_immune stringclasses 7 values	observed_changes_metabolic stringclasses 9 values	observed_changes_neuro_network stringclasses 10 values	observed_changes_gut_microbiome stringclasses 5 values	observed_changes_sleep stringclasses 9 values	observed_changes_subjective stringclasses 10 values	ripple_sequence_top6 stringclasses 10 values	lag_structure stringclasses 8 values	propagation_signature stringclasses 6 values	ripple_evidence stringclasses 10 values	constraints stringclasses 1 value	gold_checklist stringclasses 5 values
IRCS-001	Vagus nerve stimulation	target=parasympathetic; lever=vagal afferent; onset=minutes; pattern=repeated pulses	autonomic_vagal	POTS; high HR stand; CRP mild; poor sleep	HRV up day1; HR stand spike reduced	CRP down week2	glucose variability down week2	DMN connectivity stabilizes week2	minor shift	sleep latency improves week1	calmer; less PEM	autonomic->sleep->subjective->immune->metabolic->neuro_network	immediate_0_6h,short_6_72h,medium_3_14d	damped_convergence	Autonomic changes appear first then cascade into immune/metabolic over weeks	Under 240 words.	1 sequence
IRCS-002	Psilocybin assisted therapy	target=network reset; lever=5HT2A+context; onset=30-60m; pattern=single high dose	neuroplasticity_network	depression; inflammation mild; insomnia	HRV variable 48h	CRP down week4	appetite normalizes week2	network modularity decreases day1 then re-stabilizes	no data	sleep improves week1	mood improves day2; insight peak day1	neuro_network->subjective->sleep->autonomic->metabolic->immune	immediate_0_6h,short_6_72h,medium_3_14d,long_2_12w	delayed_phase_shift	Early network and subjective shift precede delayed immune marker change	Under 240 words.	1 sequence
IRCS-003	Prolonged fasting 72h	target=metabolic switch; lever=glycogen depletion; onset=hours; pattern=continuous deprivation	metabolic_energy	fatigue; insulin resistance; inflammation mild	resting HR down day2	CRP down week2	ketones up day2; glucose down day1	attention steadier day3	microbiome diversity shifts week2	sleep light day1 then deeper day3	clarity day3; hunger waves	metabolic->autonomic->subjective->sleep->immune->gut_microbiome	short_6_72h,medium_3_14d	amplified_cascade	Metabolic switch triggers multi-system cascade with delayed microbiome effects	Under 240 words.	1 sequence
IRCS-004	Cold exposure protocol	target=stress pulse; lever=cold shock; onset=seconds; pattern=brief repeated pulses	endocrine_stress	low mood; poor sleep; inflammation mild	HRV down after session then up baseline week2	no change	brown fat proxy up week2	arousal network up immediate	no data	sleep initially worse then improves	energy spikes then crash day1	autonomic->subjective->sleep->metabolic	immediate_0_6h,medium_3_14d	oscillatory_rebound	Initial destabilization followed by rebound adaptation over weeks	Under 240 words.	1 sequence
IRCS-005	FMT capsule course	target=microbiome reseed; lever=donor transfer; onset=days; pattern=short burst	gut_microbiome	IBS; low diversity; fatigue	HRV up week3	CRP down week6	glucose stable	brain fog improves week4	diversity up week2; butyrate up week4	sleep improves week4	less bloating week2	gut_microbiome->subjective->sleep->neuro_network->autonomic->immune	medium_3_14d,long_2_12w	delayed_phase_shift	Microbiome changes lead with delayed immune and autonomic shifts	Under 240 words.	1 sequence
IRCS-006	SSRI initiation	target=serotonin tone; lever=reuptake inhibition; onset=weeks; pattern=continuous dosing	neuroplasticity_network	anxiety; insomnia; mild inflammation	HRV improves week4	CRP unchanged	weight up week8	network connectivity stabilizes week6	no data	sleep worse week1 then improves week4	anxiety down week3	subjective->sleep->neuro_network->autonomic->metabolic	short_6_72h,medium_3_14d,long_2_12w	damped_convergence	Early subjective shift precedes slower network and autonomic stabilization	Under 240 words.	1 sequence
IRCS-007	Steroid burst	target=immune suppression; lever=glucocorticoid; onset=hours; pattern=short course	immune_inflammatory	flare; high ESR	HRV improves day2	ESR down day3	glucose up day2	brain fog down day2	no data	sleep worse day1	pain down day2	immune->subjective->autonomic->neuro_network->metabolic->sleep	immediate_0_6h,short_6_72h	paradoxical_worsening	Immune markers improve while metabolic and sleep worsen	Under 240 words.	1 paradox
IRCS-008	CBT insomnia	target=sleep regulation; lever=behavioral schedule; onset=weeks; pattern=coaching loops	sleep_circadian	insomnia; autonomic arousal	HRV up week3	CRP down week6	appetite steadier	attention improves week4	no data	sleep efficiency up week2	mood improves week3	sleep->autonomic->subjective->neuro_network->immune->metabolic	medium_3_14d,long_2_12w	damped_convergence	Sleep changes lead and propagate into autonomic and immune improvements	Under 240 words.	1 sleep
IRCS-009	Breathwork CO2 tolerance	target=autonomic tone; lever=CO2 setpoint; onset=minutes; pattern=repeated practice	autonomic_vagal	panic; low HRV	HRV up immediate; baseline up week2	CRP unchanged	glucose stable	threat network down week3	no data	sleep improves week2	panic down week2	autonomic->subjective->sleep->neuro_network	immediate_0_6h,medium_3_14d	local_only	Ripple mostly confined to autonomic and neurocognitive domains	Under 240 words.	1 local
IRCS-010	Psilocybin assisted therapy	target=network reset; lever=5HT2A+context; onset=30-60m; pattern=single high dose	neuroplasticity_network	trauma; IBS; inflammation mild	HRV variable week1	CRP down week8	appetite changes week2	network reorg day1	microbiome shifts week8	sleep improves week2	flashbacks down week3	neuro_network->subjective->sleep->autonomic->metabolic->immune->gut_microbiome	immediate_0_6h,short_6_72h,long_2_12w	amplified_cascade	Broad coupling yields multi-domain ripple with long-lag gut/immune changes	Under 240 words.	1 cascade

What this dataset tests

Whether a model can map cross-system ripple propagation
from a single intervention perturbation.

Required outputs

ripple_sequence_top6
lag_structure
propagation_signature

Systems tracked

autonomic
immune
metabolic
neuro_network
gut_microbiome
sleep
subjective_experience

Lag structure labels

immediate_0_6h
short_6_72h
medium_3_14d
long_2_12w

Propagation signature labels

damped_convergence
amplified_cascade
oscillatory_rebound
delayed_phase_shift
local_only
paradoxical_worsening

Typical failures

listing changes without ordering them
missing lag structure
confusing local-only with damped convergence

Suggested prompt wrapper

System

You map ripple propagation across systems.

User

Perturbation profile
{perturbation_profile}

Baseline
{baseline_state_snapshot}

Observed changes
Autonomic: {observed_changes_autonomic}
Immune: {observed_changes_immune}
Metabolic: {observed_changes_metabolic}
Neuro: {observed_changes_neuro_network}
Gut: {observed_changes_gut_microbiome}
Sleep: {observed_changes_sleep}
Subjective: {observed_changes_subjective}

Return

top 6 ripple sequence as A->B->C
lag structure labels
propagation signature
one sentence evidence

Citation

ClarusC64 dataset family

Downloads last month: 11

Number of rows:

Total file size:

13.4 kB