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36,800,818 | Evaluating the effect of nurses supportive and educational care on GATA2 gene expression and quality of life in patients with endometriosis. | Endometriosis is one of the womens aggressive but benign diseases, formed by the presence of endometrial glands and stroma outside the uterine cavity. Various genes, including the GATA2 gene, are involved in the pathogenesis of endometriosis. Since this disease affects patients quality of life, this study was conducted... |
36,800,748 | 18F-FDG PET-CT in Cutaneous Metastases in Breast Carcinoma An unusual presentation. | Cutaneous and subcutaneous metastases are an exceedingly rare presentation in various malignancies. These represent poor prognosis and disease progression. Early detection of such findings helps in changing the management plan. 18F-FDG PET-CT has played a key role in deciding treatment plan for patients with breast can... |
36,800,716 | Efficacy of pre - operative axillary ultrasonography in excluding nodal disease Can it replace sentinel lymph node biopsy in early stage breast cancer | To determine false negative rate, negative predictive value and the factors predicting false negativity of pre-treatment axillary ultrasound. The retrospective study was conducted at Shaukat Khanum Memorial Cancer Hospital, Lahore, Pakistan, and comprised data from January 2019 to December 2020 of patients with normal ... |
36,800,710 | Is complete pathological response truly a complete response in breast cancer | To check if complete pathological response in breast cancer is a good prognostic factor. The retrospective study was conducted at the Shaukat Khanum Memorial Cancer Hospital and Research Centre, Lahore, Pakistan, and comprised data from January 2012 to December 2015 of all patients who received neo-adjuvant chemotherap... |
36,800,640 | Experiences of a Multiethnic Cohort of Patients Enrolled in a Financial Reimbursement Program for Cancer Clinical Trials. | Financial reimbursement programs (FRPs) offset out-of-pocket (OOP) expenses from therapeutic clinical trial (TCT) participation. The study explores patients experience in TCTs after enrollment in a FRP at two academic medical centers, including barriers and opportunities to improve trial participation. From May 2019 to... |
36,800,620 | Breast cancer knowledge in Lebanese females with positive family history. | Breast cancer is the most commonly diagnosed cancer in women and the second leading cause of cancer-related death worldwide. Positive family history increases the likelihood of developing this disease. As late-stage presentation and poor survival rates are associated with a lack of knowledge about breast cancer and its... |
36,800,575 | Screening and identification of hub-gene associated with brain metastasis in breast cancer. | The presence of breast cancer in the brain, also known as brain metastasis (BMS), is the primary reason for a bad prognosis in cases of breast cancer. Breast cancer is the most prevalent malignant tumor seen in women in developing nations. At present, there is no effective method to inhibit brain metastasis of breast c... |
36,800,561 | RacialEthnic Disparity in the Relationship of Mental and Physical Health With Colorectal Cancer Screening Utilization Among Breast and Prostate Cancer Survivors. | We examined colorectal cancer (CRC) screening utilization among non-Hispanic White, non-Hispanic Black (NHB), non-Hispanic other (NHO)Hispanic cancer survivors. We also determined whether experiencing poor physical andor mental health affects CRC screening utilization in breast and prostate cancers across different rac... |
36,800,556 | Perceptions of Transgender and Nonbinary Persons Toward Breast and Cervical Cancer Development, Screening, and Potential Impact on Gender-Affirming Hormone Therapy. | Approximately 1.6% of adult Americans identify as transgender (TG) or nonbinary (NB) and many take gender-affirming hormone therapy (GAHT). Little data exist to inform breast and cervical cancer risks, gender-specific screening guidelines, and inclusive cancer treatment algorithms that consider GAHT. We aimed to assess... |
36,800,552 | Incremental Health Care Costs of Anxiety and Depression Among Medicare Beneficiaries With Cancer. | Mental health comorbidities are commonplace among patients with cancer and have been associated with adverse health outcomes and elevated health care costs. Given the rapidly evolving cancer care landscape, an updated understanding of the prevalence and costs of mental health conditions among patients with cancer is ne... |
36,800,539 | Applications of Artificial Intelligence in Breast Pathology. | Increasing implementation of whole slide imaging together with digital workflow and advances in computing capacity enable the use of artificial intelligence (AI) in pathology, including breast pathology. Breast pathologists often face a significant workload, with diagnosis complexity, tedious repetitive tasks, and semi... |
36,800,443 | SGN-CD228A is an investigational CD228-directed antibody-drug conjugate with potent antitumor activity across a wide spectrum of preclinical solid tumor models. | SGN-CD228A is an investigational antibody-drug conjugate (ADC) directed to melanotransferrin (CD228, MELTF, MFI2, p97), a cell-surface protein first identified in melanoma. SGN-CD228A consists of a humanized antibody, hL49, with high specificity and affinity for CD228 that is stably conjugated to 8 molecules of the cli... |
36,800,412 | Immunosuppressive reprogramming of neutrophils by lung mesenchymal cells promotes breast cancer metastasis. | Neutrophils, the most abundant innate immune cells, function as crucial regulators of the adaptive immune system in diverse pathological conditions, including metastatic cancer. However, it remains largely unknown whether their immunomodulatory functions are intrinsic or acquired within the pathological tissue environm... |
36,800,370 | Rapid generation of homogenous tumor spheroid microtissues in a scaffold-free platform for high-throughput screening of a novel combination nanomedicine. | Combination nanomedicine is a potent strategy for cancer treatment. Exploiting different mechanisms of action, a novel triple drug delivery system of 5-fluorouracil, curcumin, and piperine co-loaded human serum albumin nanoparticles (5FU-CUR-PIP-HSA-NPs) was developed via the self-assembly method for suppressing breast... |
36,800,273 | Breast Cancer and Physiologic Avidity From Breast Feeding on FDG PETCT. | A 35-year-old woman presented with breast cancer diagnosed during pregnancy. Eleven days after delivery, the patient underwent FDG PETCT for systemic staging. Avidity was seen diffusely in both breasts, with a more avid focus at the site of a biopsy clip in the right breast. There were no lymph nodes or distant metasta... |
36,800,243 | Increased 18F-Fluoroestradiol Uptake of Radiation Pneumonitis in a Patient With Metastatic Breast Cancer. | A 42-year-old woman diagnosed with de-novo stage IV breast cancer underwent 18F-fluoroestradiol (FES) PETCT to evaluate the estrogen receptor status of metastatic lesions. The largest pulmonary nodule showed obvious FES uptake, consistent with pulmonary metastases from breast cancer. Interestingly, the images revealed ... |
36,800,175 | A Transcriptomic and Reverse-Engineering Strategy Reveals Molecular Signatures of Arachidonic Acid Metabolism in 12 Cancers. | Cancer and arachidonic acid (AA) have important linkages. For example, AA metabolites regulate several critical biological functions associated with carcinogenesis angiogenesis, apoptosis, and cancer invasion. However, little is known about the comparative changes in metabolite expression of the arachidonic acid pathwa... |
36,800,118 | Changes in mammographic density and risk of breast cancer among a diverse cohort of women undergoing mammography screening. | Mammographic density (MD) is a strong breast cancer risk factor. MD may change over time, with potential implications for breast cancer risk. Few studies have assessed associations between MD change and breast cancer in racially diverse populations. We investigated the relationships between MD and MD change over time a... |
36,800,117 | Screening behaviours, demographics, and stage at diagnosis in the publicly funded Ontario Breast Screening Program. | The Ontario Breast Screening Program (OBSP) offers free screening mammograms every 2 years, to women aged 50-74. Study objectives were to determine demographic characteristics associated with the adherence to OBSP and if women screened in the OBSP have a lower stage at diagnosis than non-screened eligible women. We use... |
36,800,111 | Justifying Ribociclib Dose in Patients with Advanced Breast Cancer with Renal Impairment Based on PK, Safety, and Efficacy Data An Innovative Approach Integrating Data from a Dedicated Renal Impairment Study and Oncology Clinical Trials. | Renal impairment is common in patients with cancer and can alter the PK and thus the safety and efficacy of drugs. We assessed the impact of renal impairment during treatment with ribociclib, a cyclin-dependent kinase 46 inhibitor, and determined dose recommendations for patients with advanced breast cancer with renal ... |
36,800,077 | Breast Cancer Screening Should Embrace Precision Medicine Evidence by Reviewing Economic Evaluations in China. | The cost-effectiveness of conventional population-based breast cancer screening strategies (e.g. mammography) has been found controversial, while evidence shows that genetic testing for early detection of pathogenic variants is cost-effective. We aimed to review the economic evaluations of breast cancer screening in Ch... |
36,800,056 | Protein kinase D1 overexpression potentiates epidermal growth factor signaling pathway in MCF-7 cells. | Protein kinase D1, PKD1, is a serine-threonine kinase implicated in cell proliferation, migration, invasion, andor apoptosis and its activation by several growth factors sets this enzyme as a key regulator of tumorigenesis and tumor progression. Despite many studies, its role in the regulation of intracellular signalin... |
36,799,863 | Dysregulation of mitochondrial translation caused by CBFB deficiency cooperates with mutant PIK3CA and is a vulnerability in breast cancer. | Understanding functional interactions between cancer mutations is an attractive strategy for discovering unappreciated cancer pathways and developing new combination therapies to improve personalized treatment. However, distinguishing driver gene pairs from passenger pairs remains challenging. Here, we designed an inte... |
36,799,717 | High Dynamic Range Dual-Modal White Light Imaging Improves the Accuracy of Tumor Bed Sampling After Neoadjuvant Therapy for Breast Cancer. | Accurate evaluation of residual cancer burden remains challenging because of the lack of appropriate techniques for tumor bed sampling. This study evaluated the application of a white light imaging system to help pathologists differentiate the components and location of tumor bed in specimens. The high dynamic range du... |
36,799,690 | Overview of Adductomics in Toxicology. | Adductomics is epidemiology at the molecular level. Untargeted adductomics compares levels of chemical adducts on albumin, hemoglobin, and DNA between healthy and exposed individuals. The goal is to determine a cause-and-effect relationship between chemical exposure and illness. Chemical exposures are not necessarily d... |
36,799,539 | Novel synthetic derivatives of cinnamic and | null |
36,799,501 | Changes in Stage at Presentation among Lung and Breast Cancer Patients During the COVID-19 Pandemic. | The COVID-19 pandemic altered access to healthcare by decreasing number of patients able to receive preventative care and cancer screening. We hypothesized that given these changes in access to care, radiologic screening for breast and lung cancer would be decreased, and patients with these cancers would consequently p... |
36,799,369 | Enhanced characterization of breast cancer phenotypes using Raman micro-spectroscopy on stainless steel substrate. | Biochemical insights into varying breast cancer (BC) phenotypes can provide a fundamental understanding of BC pathogenesis, while identifying novel therapeutic targets. Raman spectroscopy (RS) can gauge these biochemical differences with high specificity. For routine RS, cells are traditionally seeded onto calcium fluo... |
36,799,362 | Broad reactivity and enhanced potency of recombinant anti-EGFR × anti-CD3 bispecific antibody-armed activated T cells against solid tumours. | null |
36,799,204 | Dairy animals and breast cancer reflections on a long-term study from the 1970s that was never done. | In this short commentary I recall a long-term experiment that was sketched out to determine if the low incidence of mammary cancer in dairy animals reflects a low incidence in these species generally or is the result of a protective effect of early pregnancy and long lactations. Although that experiment was never done,... |
36,799,191 | Effect of DPP4CD26 expression on SARS‑CoV‑2 susceptibility, immune response, adenosine (derivatives m | The worldwide COVID‑19 pandemic was brought on by a new coronavirus (SARS Cov‑2). A markerreceptor called Dipeptidyl peptidase 4CD26(DPP4CD26) may be crucial in determining susceptibility to tumors and coronaviruses. However, the regulation of DPP4 in COVID‑invaded cancer patients and its role on small molecule compoun... |
36,799,186 | LAPTM5 regulated by FOXP3 promotes the malignant phenotypes of breast cancer through activating the Wntβ‑catenin pathway. | Breast cancer remains the most common malignancy and the leading cause of cancer‑associated mortality in women worldwide. Lysosomal protein transmembrane 5 (LAPTM5), a lysosomal membrane protein, plays an important role in several human malignancies. However, the biological functions and mechanism of LAPTM5 in breast c... |
36,799,150 | Lactate secreted via MCT4 from bone‑colonizing breast cancer excites sensory neurons via GPR81. | Breast cancer (BC) bone metastasis causes bone pain (BP), which detrimentally damages the quality of life and outcome of patients with BC. However, the mechanism of BC‑BP is poorly understood, and effective treatments are limited. The present study demonstrated a novel mechanism of BC‑BP using a mouse model of bone pai... |
36,799,119 | THE EFFECT OF ADJUVANT RADIOTHERAPY ON SKIN BIOPHYSICAL PROPERTIES IN PATIENTS WITH BREAST CANCER AT RISK FOR BREAST LYMPHEDEMA A PROSPECTIVE STUDY. | Breast cancer (BC) is the most common type of cancer among women. Radiotherapy (RT) is one of the main and primary treatment options for BC, especially in breast-conserving surgery (BCS). BC patients who underwent RT experience a wide range of symptoms, in which breast edema and irritation of the skin take the lions sh... |
36,798,947 | A dose planning study for cardiac and lung dose sparing techniques in left breast cancer radiotherapy Can free breathing helical tomotherapy be considered as an alternative for deep inspiration breath hold | To investigate the possibility to be able to offer left sided breast cancer patients, not suitable for DIBH, an organ at risk saving treatment. Twenty patients receiving radiotherapy for left breast cancer in DIBH were enrolled in the study. Planning CT scans were acquired in the same supine treatment position in FB an... |
36,798,812 | The optimal regional irradiation volume for breast cancer patients A comprehensive systematic review and network meta-analysis of published studies. | Currently, the optimal adjuvant regional nodal irradiation (RNI) volume for breast cancer (BC) remained controversial. We aimed to define the optimal RNI treatment volume for BC by using a comprehensive network meta-analysis (NMA) of published studies. PubMed, Embase, Medline, and Cochrane Central Register of Controlle... |
36,798,807 | Dual Sensitization Anti-Resistant Nanoparticles for Treating Refractory Breast Cancers via Apoptosis-Inducing. | Current chemotherapy fails to offer a desirable efficacy in clinical treatment against breast cancer due to the extensive multi-drug resistance. In this study, we developed dual sensitization anti-resistant nanoparticles to treat refractory breast cancer, aiming to benefit from photodynamic therapy and chemotherapy. Hy... |
36,798,787 | Prognostic Significance of the CXCLs and Its Impact on the Immune Microenvironment in Ovarian Cancer. | The chemokine (C-X-C motif) ligand (CXCL) family in tumor tissue is closely related to tumor growth, metastasis, and survival. However, the differential expression profile and prognostic value of the CXCLs in ovarian cancer (OC) have not been elucidated. Therefore, we studied the expression levels and mutations of CXCL... |
36,798,786 | Myocardial Infarction-Induced INSL6 Decrease Contributes to Breast Cancer Progression. | Myocardial infarction (MI) induces early-stage breast cancer progression and increases breast cancer patients mortality and morbidity. Insulin-like peptide 6 (INSL6) overexpression can impede cardiotoxin-induced injury through myofiber regeneration, playing a significant role in MI progression. To investigate the diver... |
36,798,745 | Flexible human serum albumin nanocapsules to enhance drug delivery and cellular uptake for photodynamicchemo cancer therapy. | As a non-invasive cancer treatment, photodynamic therapy (PDT) has great applications in superficial tumors because of its high selectivity and low cumulative toxicity. However, the poor tumor-targeting ability and short blood circulation time of conventional photosensitizers (PSs) limit the efficacy of PDT to some ext... |
36,798,690 | End-of-neoadjuvant treatment circulating microRNAs and HER2-positive breast cancer patient prognosis An exploratory analysis from NeoALTTO. | The absence of breast cancer cells in surgical specimens, Patients treated within the trastuzumab arm ( Starting from 23 circulating miRNAs associated with EFS in the training set, we generated a 3-circulating miRNA prognostic signature consisting of miR-185-5p, miR-146a-5p, miR-22-3p, which was confirmed in the testin... |
36,798,680 | Intermammary breast cancer A rare case of cancer with origin of breast cells in an unusual location. | The most common type of cancer among the female population is breast cancer. The most common site for the occurrence of breast cancer is the upper outer quadrant the upper inner quadrant is the second site, and both the lower outer and the lower inner quadrants are in the third place. This problem is rarely seen in the... |
36,798,671 | Corrigendum Systemic treatment of breast cancer. 1st Central-Eastern European professional Consensus Statement on breast cancer. | This corrects the article DOI 10.3389pore.2022.1610383.. |
36,798,607 | National Patterns of Early Adoption of Magnetic Resonance Imaging-Guided Linear Accelerators in 2018 to 2019. | Adaptive magnetic resonance imaging-guided linear accelerators (aMRI-LINACs) are an emerging technology with the potential to improve radiation treatment for cancer through improved visualization and adaptive treatment. Given the competing forces of the increased cost, knowledge, and staff required for aMRI-LINAC thera... |
36,798,606 | Estimating Carbon Dioxide Emissions and Direct Power Consumption of Linear Accelerator-Based External Beam Radiation Therapy. | Climate change is one of the direst health threats that humanity faces. We aim to estimate the carbon dioxide (CO We identified patients with the 4 most common cancer types treated with curative-intent EBRT. Beam-on time for each fraction was extracted from the treatment planning system and averaged over each site and ... |
36,798,532 | Smart Chondroitin Sulfate Micelles for Effective Targeted Delivery of Doxorubicin Against Breast Cancer Metastasis. | Metastasis is a major challenge in breast cancer therapy. The successful chemotherapy of breast cancer largely depends on the ability to block the metastatic process. Herein, we designed a dual-targeting and stimuli-responsive drug delivery system for targeted drug delivery against breast cancer metastasis. AS1411 apta... |
36,798,467 | Role of miR‑200 family in brain metastases A systematic review. | Brain metastasis (BM) represents the single most severe neurological complication of systemic cancer. The prognosis of patients with BM is poor, irrespective of the implemented treatment. The present study performed a systematic review of the literature using three online databases (PubMed, Scopus and Web of Science). ... |
36,798,429 | Translation and linguistic validation of the Pittsburgh Fatigability Scale for Korean breast cancer survivors A cognitive interviewing study. | Fatigability-the perception of fatigue contextualized to activities of fixed intensity and duration-has received growing attention in oncology research. This study aimed to translate and linguistically validate a Korean-language version of the Pittsburgh Fatigability Scale. Following the Linguistic Validation Manual fo... |
36,798,383 | Environmentally Induced Sperm RNAs Transmit Cancer Susceptibility to Offspring in a Mouse Model. | DNA sequence accounts for the majority of disease heritability, including cancer. Yet, not all familial cancer cases can be explained by genetic factors. It is becoming clear that environmentally induced epigenetic inheritance occurs and that the progenys traits can be shaped by parental environmental experiences. In h... |
36,798,342 | Chemoproteomic Profiling Reveals that Anti-Cancer Natural Product Dankastatin B Covalently Targets Mitochondrial VDAC3. | Chlorinated gymnastatin and dankastatin alkaloids derived from the fungal strain |
36,798,328 | Paracrine enhancement of tumor cell proliferation provides indirect stroma-mediated chemoresistance via acceleration of tumor recovery between chemotherapy cycles. | The ability of tumors to survive therapy is mediated not only by cell-intrinsic but also cell-extrinsic, microenvironmental mechanisms. Across many cancers, including triple-negative breast cancer (TNBC), a high stromatumor ratio correlates with poor survival. In many contexts, this correlation can be explained by the ... |
36,798,316 | LINKIN-associated proteins necessary for tissue integrity during collective cell migration. | Cell adhesion plays essential roles in almost every aspect of metazoan biology. Previously, using the developmental migration of the nematode male gonad as a platform, LINKIN (Human ITFG1, |
36,798,307 | Breast adipose tissue-derived extracellular vesicles from women with obesity stimulate mitochondrial-induced dysregulated tumor cell metabolism. | Breast adipose tissue is an important contributor to the obesity-breast cancer link. Dysregulated cell metabolism is now an accepted hallmark of cancer. Extracellular vesicles (EVs) are nanosized particles containing selective cargo, such as miRNAs, that act locally or circulate to distant sites to modulate target cell... |
36,798,292 | Evaluating ChatGPT as an Adjunct for Radiologic Decision-Making. | ChatGPT, a popular new large language model (LLM) built by OpenAI, has shown impressive performance in a number of specialized applications. Despite the rising popularity and performance of AI, studies evaluating the use of LLMs for clinical decision support are lacking. To evaluate ChatGPTs capacity for clinical decis... |
36,798,154 | Diffsig Associating Risk Factors With Mutational Signatures. | Somatic mutational signatures elucidate molecular vulnerabilities to therapy and therefore detecting signatures and classifying tumors with respect to signatures has clinical value. However, identifying the etiology of the mutational signatures remains a statistical challenge, with both small sample sizes and high vari... |
36,798,137 | LRRC3B and its promoter hypomethylation status predicts response to anti-PD-1 based immunotherapy. | The leucine rich repeat containing 3B (LRRC3B) gene is a tumor suppressor gene involved in the anti-tumor immune microenvironment. Expression of LRRC3B and DNA methylation at the LRRC3B promoter region may serve as a useful marker to predict response to anti-PD-1 therapy. However, no studies have yet systematically exp... |
36,798,090 | Translating an Economic Analysis into a Tool for Public Health Resource Allocation in Cancer Survivorship. | Model complexity and unclear purpose are 2 barriers that prevent lay users from integrating decision science tools into their workflow.Modelers could integrate the user-centered design framework when developing a model for lay users to reduce complexity and ensure the model meets the needs of the users. |
36,798,062 | Small-cell lung cancer metastasis to a meningioma Case report and review of the literature. | Tumor-to-tumor metastasis is a rare event with meningioma as the recipient tumor accounting for 20% of the reported cases. The most common primary cancers showing this phenomenon are lung and breast cancer. Most lung cancers metastasizing to a meningioma are due to lung adenocarcinoma with the literature containing onl... |
36,797,833 | Positive Nipple Margins and Oncologic Outcomes of Nipple-Sparing Mastectomy in a Large Community-Based Hospital System. | The American Society of Breast Surgeons recommends sending separate nipple margins (NMs) when performing nipple-sparing mastectomies (NSMs). However, the definition of a positive NM is vague. We evaluated NM management and outcomes in breast cancer patients undergoing NSM from 2010 to 2021 at our community-based hospit... |
36,797,821 | Factors associated with anxiety and depression in cancer patients Demographic factors and the role of demoralization and satisfaction with care. | Anxiety and depression are common in cancer patients and seem to affect quality of life, treatment compliance and even survival. Defining factors related to anxiety and depression and exploring the role of demoralization and satisfaction with care, could contribute to the improvement of patients quality of life and qua... |
36,797,769 | Targeting tumor exosomal circular RNA cSERPINE2 suppresses breast cancer progression by modulating MALT1-NF-𝜅B-IL-6 axis of tumor-associated macrophages. | Circular RNAs (circRNAs) have important regulatory functions in cancer, but the role of circRNAs in the tumor microenvironment (TME) remains unclear. Moreover, we also explore the effects of si-circRNAs loaded in nanoparticles as therapeutic agent for anti-tumor in vivo. We conducted bioinformatics analysis, qRT-PCR, E... |
36,797,737 | Participation in screening for breast and cervical cancer among women with current or previous drug use a survey study. | Women with current or previous drug use (WCPDU) have an increased risk of poor breast and cervical cancer outcomes. Screening is known to decrease the mortality of these common cancer forms, but screening participation has been sparsely investigated among women with drug dependency. The aim of this study was to assess ... |
36,797,736 | Recent advances of small extracellular vesicle biomarkers in breast cancer diagnosis and prognosis. | Current clinical tools for breast cancer (BC) diagnosis are insufficient but liquid biopsy of different bodily fluids has recently emerged as a minimally invasive strategy that provides a real-time snapshot of tumour biomarkers for early diagnosis, active surveillance of progression, and post-treatment recurrence. Extr... |
36,797,689 | Expression of substance P, neurokinin 1 receptor, Ki-67 and pyruvate kinase M2 in hormone receptor negative breast cancer and evaluation of impact on overall survival. | Chronic inflammation is a hallmark of cancer, and it can be stimulated by many factors. Substance P (SP), through binding to neurokinin 1 receptor (NK1R), and pyruvate kinase M2 (PKM2) play critical roles in cancer development and progression via modulating the tumor microenvironment. This study aimed to investigate th... |
36,797,664 | Cost-effectiveness of ribociclib versus palbociclib in combination with an aromatase inhibitor as first-line treatment of postmenopausal women with HRHER2- advanced breast cancer analysis based on final OS results of MONALEESA-2 and PALOMA-2. | Background and AimsCombination of a cyclin-dependent kinase 4 and 6 (CDK46) inhibitor and an aromatase inhibitor is the standard of care first-line (1L) treatment of hormone receptor-positive (HR), human epidermal growth factor receptor 2-negative (HER2-) advanced breast cancer (ABC). Updated clinical data have become ... |
36,797,654 | Using Machine Learning Methods to Assess Lymphovascular Invasion and Survival in Breast Cancer Performance of Combining Preoperative Clinical and MRI Characteristics. | Preoperative assessment of lymphovascular invasion (LVI) in invasive breast cancer (IBC) is of high clinical relevance for treatment decision-making and prognosis. To investigate the associations of preoperative clinical and magnetic resonance imaging (MRI) characteristics with LVI and disease-free survival (DFS) by us... |
36,797,619 | Peritumoural Oedema as a Predictor of Overall Survival for Patients with Posterior Fossa Metastases. | To analyse the relationship between peritumoural oedema volume and tumour volume in relation to the impact of metastatic posterior fossa tumour survival rates. An observational study. Umraniye Training and Research Hospital, İstanbul, Turkey, from 2011-2021. Fifty-six cancer patients who had been operated upon for cere... |
36,797,615 | Effect of hybrid compounds of stilbene and pentadienone on inhibition of tubulin polymerization. | Tubulin polymerization inhibitors induce cancer cell death therefore, they can be developed as chemotherapeutic agents. We hypothesized that hybrid compounds, including the trans-stilbene moiety contained in resveratrol and penta-1,4-dien-3-one contained in curcumin, could inhibit tubulin polymerization. Twenty-six hyb... |
36,797,602 | The role of theragnostics in breast cancer a systematic review of the last 12 years. | Breast cancer is the most common malignancy in women, with high morbidity and mortality. Molecular alterations in breast cancer involve the expression or upregulation of various molecular targets that can be used for diagnostic nuclear medicine imaging and radiopharmaceutical treatment. Theragnostics is based on the bi... |
36,797,502 | Reciprocal interactions between innate immune cells and astrocytes facilitate neuroinflammation and brain metastasis via lipocalin-2. | Brain metastasis still encompass very grim prognosis and therefore understanding the underlying mechanisms is an urgent need toward developing better therapeutic strategies. We uncover the intricate interactions between recruited innate immune cells and resident astrocytes in the brain metastatic niche that facilitate ... |
36,797,466 | Defining the heterogeneity of unbalanced structural variation underlying breast cancer susceptibility by nanopore genome sequencing. | Germline structural variants (SVs) are challenging to resolve by conventional genetic testing assays. Long-read sequencing has improved the global characterization of SVs, but its sensitivity at cancer susceptibility loci has not been reported. Nanopore long-read genome sequencing was performed for nineteen individuals... |
36,797,433 | Overexpression of POU3F2 promotes radioresistance in triple-negative breast cancer via Akt pathway activation. | POU3F2 is associated with malignant behaviors and poor prognosis in cancer. However, the function and mechanism of POU3F2 in breast cancer remain to be elucidated. Our study aimed to explore the role of POU3F2 in triple-negative breast cancer and radiotherapy. POU3F2 expression was examined by RT-PCR and Western blot. ... |
36,797,360 | Translating transcriptomic findings from cancer model systems to humans through joint dimension reduction. | Model systems are an essential resource in cancer research. They simulate effects that we can infer into humans, but come at a risk of inaccurately representing human biology. This inaccuracy can lead to inconclusive experiments or misleading results, urging the need for an improved process for translating model system... |
36,797,357 | Clinical outcome and prognostic factors for Asian patients in Phase I clinical trials. | Patient selection is key in Phase I studies, and prognosis can be difficult to estimate in heavily pre-treated patients. Previous prognostic models like the Royal Marsden Hospital (RMH) score or using the neutrophil-lymphocyte ratio (NLR) have not been validated in current novel therapies nor in the Asian Phase I popul... |
36,797,347 | AKTmTOR signaling modulates resistance to endocrine therapy and CDK46 inhibition in metastatic breast cancers. | Endocrine therapy (ET) in combination with CDK46 inhibition is routinely used as first-line treatment for HRHER2- metastatic breast cancer (MBC) patients. However, 30-40% of patients quickly develop disease progression. In this open-label multicenter clinical trial, we utilized a hypothesis-driven proteinphosphoprotein... |
36,797,245 | Regulation of the tumor immune microenvironment by cancer-derived circular RNAs. | Circular RNA (circRNAs) is a covalently closed circular non-coding RNA formed by reverse back-splicing from precursor messenger RNA. It is found widely in eukaryotic cells and can be released to the surrounding environment and captured by other cell types. This, circRNAs serve as connections between different cell type... |
36,797,240 | Polo-like kinase 4 (Plk4) potentiates anoikis-resistance of p53KO mammary epithelial cells by inducing a hybrid EMT phenotype. | Polo-like kinase 4 (Plk4), the major regulator of centriole biogenesis, has emerged as a putative therapeutic target in cancer due to its abnormal expression in human carcinomas, leading to centrosome number deregulation, mitotic defects and chromosomal instability. Moreover, Plk4 deregulation promotes tumor growth and... |
36,797,222 | Iodine-125 seed versus hook-wire guided breast conserving surgery do post operative complication rates differ | Radio-guided occult lesion localisation using iodine 125 seeds (ROLLIS) is used to localize impalpable breast cancers for breast conserving surgery (BCS). Previous studies have suggested improved efficiency and patient outcomes with ROLLIS compared with hook-wire localisation (HWL). The aim of this report is to compare... |
36,797,105 | Psychosocial needs of older patients with metastatic breast cancer treated at community centers. | Psychosocial status contributes to overall quality of life (QOL) for patients with cancer as psychosocial distress is commonly seen in this population. We sought to describe the psychosocial needs of older adults with metastatic breast cancer (MBC) treated in the community. We evaluated the correlation between the pati... |
36,796,936 | Lessons from other fields of medicine, Part 1 Breast cancer. | Through the understanding of multiple etiologies, pathologies, and disease progression trajectories, breast cancer shifted historically from a singular malignancy of the breast to a complex of molecularbiological entities, translating into individualized disease-modifying treatments. As a result, this led to various de... |
36,796,822 | Renaissance of prepectoral implant-based breast reconstruction theoretical basis and research status. | To overview the theoretical basis and research status of prepectoral implant-based breast reconstruction. The domestic and foreign researches on the application of prepectoral implant-based breast reconstruction in breast reconstruction were retrospectively analyzed. The theoretical basis, clinical advantages, and limi... |
36,796,704 | Propranolol reduces IFN-γ driven PD-L1 immunosuppression and improves anti-tumour immunity in ovarian cancer. | The immune system plays an important role in controlling epithelial ovarian cancer (EOC). EOC is considered to be a cold tumour, a tumour that has not triggered a strong response by the immune system. However, tumour infiltrating lymphocytes (TILs) and the expression of programmed cell death ligand (PD-L1) are used as ... |
36,796,670 | PLA2G2A | Our previous research defined a novel metabolic cancer associated fibroblasts subset (meCAFs) enriched in loose-type pancreatic ductal adenocarcinoma (PDAC) and related toCD8 |
36,796,556 | Putative interactions between transthyretin and endosulfan II and its relevance in breast cancer. | The unregulated use of organochlorine pesticides has been linked to spread of breast cancer (BC), but the underlying biomolecular interactions are unknown. Using a case-control study, we compared OCP blood levels and protein signatures among BC patients. Five pesticides were found in significantly higher concentrations... |
36,796,499 | A local strategy towards concurrent chemoradiotherapy based on fibrin gel for post-surgical cancer treatment. | Postoperative cancer recurrence and metastasis have always been a huge challenge in cancer therapy. Concurrent cisplatin (CDDP)-based chemoradiotherapy regimen is a standard therapeutic strategy in some cancer treatment after surgical resection. However, severe side-effects and unsatisfactory local tumor concentrations... |
36,796,498 | Phase II Study of Preoperative Stereotactic Ablative Body Radiotherapy for Early-Stage Breast Cancer Introduction of a Novel Form of Accelerated Partial Breast Radiotherapy. | Pre-operative delivery of partial breast irradiation (PBI) facilitates smaller target volumes and reduced dose to normal tissues. We hypothesized that pre-operative stereotactic ablative radiotherapy (SABR) delivered to intact breast tumor would achieve pathological complete response (pCR) in 25% of patients while pres... |
36,796,341 | Clinical impact of fine needle aspiration cytology on sentinel node biopsy after preoperative chemotherapy for core needle biopsy-proven metastatic lymph nodes. | Sentinel node biopsy (SNB) has been increasingly performed for patients with lymph node (LN)-positive (cN1) breast cancer that converted to LN-negative (ycN0) status after neoadjuvant chemotherapy (NAC). This study aimed to clarify the SNB avoidance rates using fine needle aspiration cytology (FNAC) for mLNs after NAC.... |
36,796,115 | The Negative Impact of the New Coronavirus Pandemic on the Trend of Breast Biopsies and Their Direct Costs Interrupted Time Series Analysis. | The overload of health services because of the COVID-19 pandemic has reduced the populations access to treatment and prevention of other diseases. This study aimed to identify whether there was a change in the trend of breast biopsies and their direct costs during the COVID-19 pandemic in a developing countrys public a... |
36,796,040 | Reverse Abdominoplasty for Mastectomy Defect Closure in Advanced Breast Cancer. | Breast cancer patients with locally advanced breast cancer who require radical mastectomy are left with large chest wall defects. This poses a significant reconstructive challenge as many high-risk patients require timely postmastectomy adjuvant therapy. While the reverse abdominoplasty technique is commonly used for a... |
36,795,990 | Access to Radiation Therapy and Related Clinical Outcomes in Patients With Cervical and Breast Cancer Across Sub-Saharan Africa A Systematic Review. | To better understand the barriers to accessing standard-of-care radiation therapy (RT) for breast and cervical cancer in sub-Saharan Africa and their impact on outcomes. A comprehensive literature search was completed with a medical librarian. Articles were screened by title, abstract, and full text. Included publicati... |
36,795,989 | Cancer-Related Stigma in Malawi Narratives of Cancer Survivors. | Stigma is an impediment across the cancer care continuum, leading to delayed presentation to care, elevated morbidity and mortality, and reduced quality of life. The goal of this study was to qualitatively examine the drivers, manifestations, and impacts of cancer-related stigma among individuals who received cancer tr... |
36,795,958 | Duplex Phenotype Detection and Targeting of Breast Cancer Cells Using Nanotube Nanoprobes and Raman Imaging. | We designed, synthesized, and characterized a Raman nanoprobe made of dye-sensitized single-walled carbon nanotubes (SWCNTs) that can selectively target biomarkers of breast cancer cells. The nanoprobe is composed of Raman-active dyes encapsulated inside a SWCNT, whose surface is covalently grafted with poly(ethylene g... |
36,795,771 | Perceived Participation in Decision-Making on Primary Surgery and Associated Factors Among Early Breast Cancer Patients A Cross-sectional Study. | Breast cancer patients wish to participate in the treatment decision-making, but the perceived participation was inconsistent with the willingness, leading to poor patient outcomes. The aims of this study were to explore the perceived participation in the primary surgery decision-making among Chinese patients with earl... |
36,795,754 | lncRNA | Notch has been implicated in human cancers and is a putative therapeutic target. However, the regulation of Notch activation in the nucleus remains largely uncharacterized. Therefore, characterizing the detailed mechanisms governing Notch degradation will identify attractive strategies for treating Notch-activated canc... |
36,795,733 | Drivers of disparities in stage at diagnosis among women with breast cancer South African breast cancers and HIV outcomes cohort. | In low- and middle-income countries (LMICs), advanced-stage diagnosis of breast cancer (BC) is common, and this contributes to poor survival. Understanding the determinants of the stage at diagnosis will aid in designing interventions to downstage disease and improve survival from BC in LMICs. Within the South African ... |
36,795,663 | Cancer detection for small-size and ambiguous tumors based on semantic FPN and transformer. | Early detection of tumors has great significance for formative detection and determination of treatment plans. However, cancer detection remains a challenging task due to the interference of diseased tissue, the diversity of mass scales, and the ambiguity of tumor boundaries. It is difficult to extract the features of ... |
36,795,596 | Breast Cancer Tumor Board A Radiologists Guide to Postmastectomy Radiation Therapy. | Radiation therapy represents a pillar in the current management of breast cancer. Historically, postmastectomy radiation therapy (PMRT) has been administered only in patients with locally advanced disease and a poor prognosis. These included patients with large primary tumors at diagnosis andor more than three metastat... |
36,795,481 | Coordinated activation of c-Src and FOXM1 drives tumor cell proliferation and breast cancer progression. | Activation of the tyrosine kinase c-Src promotes breast cancer progression and poor outcomes, yet the underlying mechanisms are incompletely understood. Here, we show that deleting c-Src abrogates the activity of Forkhead Box M1 (FOXM1), a master transcriptional regulator of the cell cycle, in a genetically engineered ... |
36,795,415 | Regulatory Approval, Reimbursement, and Clinical Use of Cyclin-Dependent Kinase 46 Inhibitors in Metastatic Breast Cancer in the Netherlands. | The number of new cancer medicines that are being approved by regulatory agents is increasing exponentially. Yet little is known about the pace at which these medicines reach eligible patients in daily clinical practice during different phases of the postapproval access pathway. To describe the entire postapproval acce... |
36,795,405 | Association of Social Determinants and Tumor Biology With Racial Disparity in Survival From Early-Stage, Hormone-Dependent Breast Cancer. | Black women with hormone receptor-positive breast cancer experience the greatest racial disparity in survival of all breast cancer subtypes. The relative contributions of social determinants of health and tumor biology to this disparity are uncertain. To determine the proportion of the Black-White disparity in breast c... |
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