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Scientific Reports | 27578529 | PMC5006166 | 10.1038/srep32404 | Large-Scale Discovery of Disease-Disease and Disease-Gene Associations | Data-driven phenotype analyses on Electronic Health Record (EHR) data have recently drawn benefits across many areas of clinical practice, uncovering new links in the medical sciences that can potentially affect the well-being of millions of patients. In this paper, EHR data is used to discover novel relationships betw... | Background and related workIn the treatment of ailments, the focus of medical practitioners can be roughly divided between two complementary approaches: 1) treating the symptoms of already sick patients (reactive medicine); and 2) understanding disease etiology in order to prevent manifestation and further spread of th... | [
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"title": "Using electronic health records to drive discovery in disease genomics.",
"abstract": "If genomic studies are to be a clinically relevant and timely reflection of the relationship between genetics and health status--whether for common or rare variants--cost-effective ways... |
Frontiers in Psychology | 27721800 | PMC5033969 | 10.3389/fpsyg.2016.01429 | Referential Choice: Predictability and Its Limits | We report a study of referential choice in discourse production, understood as the choice between various types of referential devices, such as pronouns and full noun phrases. Our goal is to predict referential choice, and to explore to what extent such prediction is possible. Our approach to referential choice include... | Related WorkAs was discussed in Section “Discussion: Referential Choice Is Not Always Categorical”, referential variation and non-categoricity is clearly gaining attention in the modern linguistic, computational, and psycholinguistic literature. Referential variation may be due to the interlocutors’ perspective taking ... | [
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"title": "The effect of additional characters on choice of referring expression: Everyone counts.",
"abstract": "Two story-telling experiments examine the process of choosing between pronouns and proper names in speaking. Such choices are traditionally attributed to speakers strivi... |
Journal of Cheminformatics | 28316646 | PMC5034616 | 10.1186/s13321-016-0164-0 | An ensemble model of QSAR tools for regulatory risk assessment | Quantitative structure activity relationships (QSARs) are theoretical models that relate a quantitative measure of chemical structure to a physical property or a biological effect. QSAR predictions can be used for chemical risk assessment for protection of human and environmental health, which makes them interesting to... | Related workThere are studies that investigate methods for combining predictions from multiple QSAR tools to gain better predictive performance for various toxic endpoints: (1) Several QSAR models were developed and compared using different clustering algorithms (multiple linear regression, radial basis function neural... | [
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"title": "The application of discovery toxicology and pathology towards the design of safer pharmaceutical lead candidates.",
"abstract": "Toxicity is a leading cause of attrition at all stages of the drug development process. The majority of safety-related attrition occurs preclin... |
JMIR Medical Education | 27731840 | PMC5041364 | 10.2196/mededu.4789 | A Conceptual Analytics Model for an Outcome-Driven Quality Management Framework as Part of Professional Healthcare Education | BackgroundPreparing the future health care professional workforce in a changing world is a significant undertaking. Educators and other decision makers look to evidence-based knowledge to improve quality of education. Analytics, the use of data to generate insights and support decisions, have been applied successfully ... | Related WorkEducational Informatics is a multidisciplinary research area that uses Information and Communication Technology (ICT) in education. It has many sub-disciplines, a number of which focus on learning or teaching (eg, simulation), and others that focus on administration of educational programs (eg, curriculum m... | [
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"title": "Recommendations of the International Medical Informatics Association (IMIA) on Education in Biomedical and Health Informatics. First Revision.",
"abstract": "Objective: The International Medical Informatics Association (IMIA) agreed on revising the existing international ... |
Scientific Reports | 27686748 | PMC5043229 | 10.1038/srep34181 | Accuracy Improvement for Predicting Parkinson’s Disease Progression | Parkinson’s disease (PD) is a member of a larger group of neuromotor diseases marked by the progressive death of dopamineproducing cells in the brain. Providing computational tools for Parkinson disease using a set of data that contains medical information is very desirable for alleviating the symptoms that can help th... | Related WorkFor effective diagnosis of Parkinson’s Disease (PD), different types of classification methods were examined by Das30. The computation of the performance score of the classifiers was based on various evaluation methods. According to the results of application scores, they found that Neural Networks (NNs) cl... | [
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"title": "Predicting Parkinson's disease - why, when, and how?",
"abstract": "Parkinson's disease (PD) is a progressive disorder with a presymptomatic interval; that is, there is a period during which the pathologic process has begun, but motor signs required for the clinical diagn... |
Scientific Reports | 27694950 | PMC5046183 | 10.1038/srep33985 | Multi-Pass Adaptive Voting for Nuclei Detection in Histopathological Images | Nuclei detection is often a critical initial step in the development of computer aided diagnosis and prognosis schemes in the context of digital pathology images. While over the last few years, a number of nuclei detection methods have been proposed, most of these approaches make idealistic assumptions about the staini... | Previous Related Work and Novel ContributionsTable 1 enumerates some recent techniques for nuclei detection. Most approaches typically tend to use image derived cues, such as color/intensity2528293031, edges192124323334, texture35, self learned features1336, and symmetry22242737.The color and texture-based methods requ... | [
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"pmid": "26186772",
"title": "Feature Importance in Nonlinear Embeddings (FINE): Applications in Digital Pathology.",
"abstract": "Quantitative histomorphometry (QH) refers to the process of computationally modeling disease appearance on digital pathology images by extracting hundreds of image feature... |
Scientific Reports | 27703256 | PMC5050509 | 10.1038/srep34759 | Feature Subset Selection for Cancer Classification Using Weight Local Modularity | "Microarray is recently becoming an important tool for profiling the global gene expression patterns(...TRUNCATED) | "Related WorkOwing to the importance of gene selection in the analysis of the microarray dataset and(...TRUNCATED) | ["23124059","17720704","16790051","11435405","15327980","11435405","22149632","15680584","16119262",(...TRUNCATED) | [{"pmid":"23124059","title":"Selection of interdependent genes via dynamic relevance analysis for ca(...TRUNCATED) |
Frontiers in Neuroscience | 27774048 | PMC5054006 | 10.3389/fnins.2016.00454 | Design and Evaluation of Fusion Approach for Combining Brain and Gaze Inputs for Target Selection | "Gaze-based interfaces and Brain-Computer Interfaces (BCIs) allow for hands-free human–computer in(...TRUNCATED) | "2. Related workThis section presents the most relevant studies related to the scope of this paper. (...TRUNCATED) | [
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JMIR Medical Informatics | 27658571 | PMC5054236 | 10.2196/medinform.5353 | Characterizing the (Perceived) Newsworthiness of Health Science Articles: A Data-Driven Approach | "BackgroundHealth science findings are primarily disseminated through manuscript publications. Infor(...TRUNCATED) | "Motivation and Related WorkThe news media are powerful conduits by which to disseminate important i(...TRUNCATED) | [
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BioData Mining | 27777627 | PMC5057496 | 10.1186/s13040-016-0110-8 | "FEDRR: fast, exhaustive detection of redundant hierarchical relations for quality improvement of la(...TRUNCATED) | "BackgroundRedundant hierarchical relations refer to such patterns as two paths from one concept to (...TRUNCATED) | "Related workThere has been related work on exploring redundant relations in biomedical ontologies o(...TRUNCATED) | [
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