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PMC10788335 | 38221532 | Introduction
Degenerative lumbar spine disease (DLSD) is one of the most common musculoskeletal conditions that affect the lower back and is characterized by the progressive deterioration of intervertebral discs, facet joints, and other structures in the lumbar region 1 , 2 . This degenerative process can cause a varie... | Methods
Data source
The data for this study were derived from the National Health Insurance Database (NHID), which records personal information, demographics, and medical treatment data for all Korean citizens. In the ROK, all citizens have been beneficiaries of the NHIS for more than 20 years, and the NHIS covers both... | Results
Baseline characteristics of the cohort
The characteristics of patients are described in Table 1 . The most common disease was LDH (47.85%) followed by LSS without SPL (36.12%), LSS with SPL (13.63%), and SP (2.4%). Open discectomy was the most common surgical technique in all diseases. The initial surgical met... | Discussion
Frequency and causes of secondary surgery in patients with degenerative lumbar spine disease
For LDH, the secondary surgery rate is reported to be 10% at 2 years, 15% at 5 years, and 20% at 10 years 11 , 32 . The most common cause of secondary surgery is known to be the recurrence of disc protrusion 16 . Fac... | Conclusion
Among patients who underwent surgery for DLSD, those who underwent secondary surgery tend to have higher interim costs than those who did not undergo secondary surgery. Furthermore, secondary surgeries generally involve higher medical expenses than the initial surgery. Therefore, tracking the trend of medica... | This study aims to identify healthcare costs indicators predicting secondary surgery for degenerative lumbar spine disease (DLSD), which significantly impacts healthcare budgets. Analyzing data from the National Health Insurance Service-National Sample Cohort (NHIS-NSC) database of Republic of Korea (ROK), the study in... | Acknowledgements
The authors appreciate the Medical Research Collaborating Center for statistical analysis and consultation.
Author contributions
C.H.K. contributed to the study's conception and design. Material preparation was performed by J.H.L., Y.H.C., S.B.P., and K.T.K. Data collection and analysis were performed ... | CC BY | no | 2024-01-16 23:41:59 | Sci Rep. 2024 Jan 14; 14:1295 | oa_package/da/f3/PMC10788335.tar.gz | |
PMC10788336 | 38221536 | Introduction
Metabolomics enables the simultaneous study of multiple metabolic processes, including pathways, transport, and reactions. Metabolomics assays are diverse and complex in terms of their analytical conditions, but they can generate quantitative and semi-quantitative data for hundreds of endogenous metabolite... | Material and methods
IDSL.GOA knowledgebase
We assembled and integrated information from a diverse set of data sources, including genes, enzymes, compounds, gene ontology terms and the relationships among them. Table 1 provides the web addresses for the publicly available data sources and their respective locations. ... | Results
Creating the IDSL.GOA metabolic knowledgebase: To perform IDSL.GOA over-representation analysis, we first needed to create a database of relationships among metabolic entities. This database was designed to capture the heterogenous relationships among genes, enzymes, compounds, and gene ontology terms. The sou... | Discussion
IDSL.GOA is the first bioinformatics tool that used GO terms for over-representation analysis of metabolomic datasets. By mapping the metabolites to their associated GO terms, IDSL.GOA can improve the mechanistic interpretation of metabolomics data by providing a functional annotation of the metabolites base... | Conclusions
In summary, the IDSL.GOA tool can enable a comprehensive and accurate biological interpretation of metabolomics data. A much-needed transition from pathway maps to GO terms for interpreting metabolomic datasets can be supported by the IDSL.GOA tool. It is more sensitive in identifying significantly enriched... | Biological interpretation of metabolomic datasets often ends at a pathway analysis step to find the over-represented metabolic pathways in the list of statistically significant metabolites. However, definitions of biochemical pathways and metabolite coverage vary among different curated databases, leading to missed int... | Supplementary Information
| Supplementary Information
The online version contains supplementary material available at 10.1038/s41598-024-51992-x.
Author contributions
P.M. and D.K.B. developed the database and online interface, prepared the figures and wrote the main manuscript text. O.F. provided the test data. All authors reviewed the manuscrip... | CC BY | no | 2024-01-16 23:41:59 | Sci Rep. 2024 Jan 14; 14:1299 | oa_package/f4/40/PMC10788336.tar.gz |
PMC10788337 | 38221530 | Introduction
Cholangiocarcinoma, a malignant cancer which initiates from the epithelial cells lining the bile ducts, is the second most common primary hepatic malignancy 1 – 3 . It is classified as being either intrahepatic or extrahepatic 4 , 5 . In Southeast Asia, especially in Thailand, cholangiocarcinoma is common ... | Materials and methods
Cholangiocarcinoma cell line
Two human cholangiocarcinoma cell lines, HuCCT1 and TFK-1, were used HuCCT1 (TKG0389) and TFK-1 (TKG0367) were purchased from Ricken Cell Bank. Both cell lines were grown in RPMI 1640 medium (Hyclone, USA) supplemented with 10% FBS (Department of Transfusion Medicine, ... | Results
Immunophenotyping of Vγ9Vδ2 T cell cultures
PBMC from healthy donors were cultured simultaneously with one of three different conditions: complete medium containing 5μM zoledronate and 200 IU IL-2/ml alone, or with 30 ng IL-15/ml, or with 30 ng IL-18/ml or with neither. All subsequent flow cytometry measurement... | Discussion
Human Vγ9Vδ2 T cells, a major subset of γδ T cells in peripheral blood, have received increased interest regarding this immune response to cancer over the past decade. Clinical trials utilizing Vγ9Vδ2 T cell-based cancer immunotherapy have been launched and their efficiency to lyse a broad range of tumor cel... | Conclusions
Taken together, data from our study support the addition of the immunostimulatory cytokines IL-15 and IL-18 to in vitro γδ T cell cultures as a feasible and efficacious approach to activation and expansion of Vγ9Vδ2 T cells. This may offer the good approach to achieve higher yields of expanded γδ T cells wi... | Human Vγ9Vδ2 T lymphocytes are regarded as promising effector cells for cancer immunotherapy since they have the ability to eliminate several tumor cells through non-peptide antigen recognition. However, the cytotoxic function and the mechanism of Vγ9Vδ2 T cells leading to specific killing of cholangiocarcinoma cells a... | Acknowledgements
This work was supported by the Thailand Research Fund under Royal Golden Jubilee Ph.D. Program Grant (No. PHD 0156/2556 to PS and KJ), Mahidol University and the Office of National Higher Education Science Research and Innovation Policy Council (NXPO), Thailand, through Program Management Unit for Comp... | CC BY | no | 2024-01-16 23:41:59 | Sci Rep. 2024 Jan 14; 14:1291 | oa_package/c2/5b/PMC10788337.tar.gz | |
PMC10788338 | 38221527 | Introduction
Traumatic brain injury (TBI) is a leading cause of death and disability worldwide 1 with incidence of 0.2–0.5% per year 2 . It is a complex, heterogeneous condition affecting a broad population, with a wide range of clinical presentations and outcomes. Despite advances toward understanding the pathophysio... | Methods
MIMIC III database
Patient information on clinical characteristics and outcomes were extracted from MIMIC-III, a large, single-centre database including 38,597 adult (≥ 16 years old) patients admitted to critical care units at, Beth Israel Deaconess Medical Center, a large tertiary care hospital in Boston, MA 2... | Results
Comorbidity characterization
We included 2,629 patients in our analysis. The mean age was 59.0, 61.9% were male, average GCS was 10.4, the mean number of comorbidities was 2.0, and the rate of survival to discharge was 36.7%. The demographics of our study cohort are summarized in Table 1 .
The relationship bet... | Discussion
Endotypes in TBI and other conditions
Our initial analyses are consistent with previous literature and clinical experience—that comorbidities are associated with clinical outcomes and that comorbidities tend to occur in patterns 44 , 45 .
In characterizing the relationship between comorbidities and clinical ... | Conclusion
TBI, like many other conditions, is complex with varied clinical and biological presentations that contribute to their heterogeneity. In this study, we demonstrate the discovery of TBI comorbidity endotypes with distinct clinical outcomes. Our results suggest that viewing clinical variables, such as the pres... | Traumatic brain injury (TBI) is a complex condition where heterogeneity impedes the advancement of care. Understanding the diverse presentations of TBI is crucial for personalized medicine. Our study aimed to identify clinically relevant patient endotypes in TBI using latent class analysis based on comorbidity data. We... | Supplementary Information
| Supplementary Information
The online version contains supplementary material available at 10.1038/s41598-024-51474-0.
Acknowledgements
We would like to thank Dr. Frank Rudzicz (University of Toronto) for his feedback and comments on the manuscript.
Author contributions
Study conception and design: H. Q., Z. Z.; data co... | CC BY | no | 2024-01-16 23:41:59 | Sci Rep. 2024 Jan 14; 14:1294 | oa_package/c8/6c/PMC10788338.tar.gz |
PMC10788339 | 38221546 | Introduction
Glioblastoma (GBM), the most lethal type of intracranial tumor, is characterized by highly infiltrative and aggressive growth, along with abundant neovascularization 1 . The current standard treatment for GBM involves surgical resection, chemotherapy and radiotherapy, a widely adopted approach for an exten... | Methods and materials
Data acquisition
Transcriptomic and clinical data of GBM patients from the Cancer Genomic Atlas (TCGA) and the Chinese Glioma Genomic Atlas (CGGA) were downloaded from the UCSC dataset ( https://xenabrowser.net/datapages/ ) and CGGA website ( http://www.cgga.org.cn/ ), respectively. A total of 516... | Results
Examining RNA modification regulators linked to angiogenesis
The role of RNA modification in the angiogenesis of GBM microenvironment remains unclear, to address this, we employed the GSEA method to identify angiogenesis-related RNA modification (RM) regulators. A total of 53 RM regulators spanning eight types ... | Discussion
RNA modification has become a focal point in cancer research, and while the role of ALKBH5 has been established in regulating endothelial cell angiogenesis via a SPHK1 dependent manner under ischemic stress, but the crosstalk between RNA modification and angiogenesis of GBM has been less explored. This compr... | Despite numerous reports indicating the significant impact of RNA modification on malignant glioblastoma (GBM) cell behaviors such as proliferation, invasion and therapy efficacy, its specific involvement in glioblastoma (GBM) angiogenesis is remains unclear and is currently under investigation. In this study, we aimed... | Supplementary Information
| Abbreviations
Glioblastoma
Gene set enrichment analysis
N6-methyladenosine
Gene ontology
Kyoto encyclopedia of genes and genomes
Human umbilical vein endothelial cell
Overall survival
Vascular endothelial growth factor
N7-methylguanosine
N1-methyladenosine
5-Methylcytidine
5-Methoxycarbonylmethyluridine
Adenosine to in... | CC BY | no | 2024-01-16 23:41:59 | Sci Rep. 2024 Jan 14; 14:1303 | oa_package/9c/0f/PMC10788339.tar.gz | |
PMC10788340 | 38221531 | Introduction
Pyroptosis is a lytic type of programmed cell death, which is initiated by inflammatory caspases and characterized by gasdermin (GSDM)-mediated membrane pore-formation and the release of cellular contents 1 , 2 Pyroptosis could be activated by extracellular or intracellular stimulation, including pathogen... | Materials and methods
Animals and orthodontic force treatment
6–8-week-old Male Sprague Dawley rats (body weight of 200–250 g) and C57BL/6N mice were obtained from Weitong Lihua Experimental Animal Center (China), and Caspase-1 −/− mice were generated by Viewsolid Biotech (Beijing, China). They were housed in control... | Results
Force induces PDL progenitor cell pyroptosis during OTM and alveolar bone remodeling in vivo
To investigate whether mechanical force-induced pyroptosis regulates alveolar bone remodeling in vivo, a classic force-induced OTM and alveolar bone remodeling model was established. Micro-CT images showed that the OTM ... | Discussion
Pyroptosis plays a vital role in activating inflammatory responses under mechanical stimuli. However, whether and how force induces PDL progenitor cell pyroptosis, thereby influencing OTM and alveolar bone remodeling is unclear. In this study, we revealed a novel mechanism that mechanical force induced pyrop... | Pyroptosis, an inflammatory caspase-dependent programmed cell death, plays a vital role in maintaining tissue homeostasis and activating inflammatory responses. Orthodontic tooth movement (OTM) is an aseptic force-induced inflammatory bone remodeling process mediated by the activation of periodontal ligament (PDL) prog... | Supplementary information
| Supplementary information
The online version contains supplementary material available at 10.1038/s41368-023-00268-7.
Acknowledgements
We thank Dr. S.C. for providing Caspase-1 −/− mice. This work was supported by the National Natural Science Foundations of China No. 82230030, No. 81871492 (Y.L.) and No. 82170996 (D.... | CC BY | no | 2024-01-16 23:41:59 | Int J Oral Sci. 2024 Jan 15; 16:3 | oa_package/91/05/PMC10788340.tar.gz | |
PMC10788341 | 38221519 | GJA1 is the causative gene for oculodentodigital dysplasia (ODDD). A novel de novo GJA1 variant, NM 000165:c263C > T [p.P88L], was identified in a mosaic state in a patient with short stature, seizures, delayed myelination, mild hearing loss, and tooth enamel hypoplasia. Although the patient exhibited severe neurode... | Oculodentodigital dysplasia (ODDD [MIM: 164200]) is characterized by multiple congenital anomalies 1 . The major clinical features include (1) distinctive facial findings, including a thin nose with hypoplastic ala nasi, small anteverted nares, prominent columella, and microcephaly; (2) eye findings, such as microphtha... | Supplementary information
The online version contains supplementary material available at 10.1038/s41439-023-00262-9.
Author contributions
T.Y. designed this study. R.S. was involved in organizing this study and drafting the manuscript. T.Y., K.I., M.S., T.S., K.I., and S.N. contributed to the acquisition of clinical d... | CC BY | no | 2024-01-16 23:41:59 | Hum Genome Var. 2024 Jan 15; 11:2 | oa_package/b5/2b/PMC10788341.tar.gz | |||||
PMC10788342 | 38221517 | Introduction
Medicinal plants are high in phytochemicals and antibacterial compounds. Various medicinal plant components are harvested for their diverse therapeutic properties 1 . Medicinal plants have been utilized in folk medicine in Saudi Arabia and the rest of the Arabian Peninsula throughout the dawn of time to cu... | Materials and methods
Plant collection
Fresh leaves of R. stricta were obtained from the desert surrounding Riyadh, Saudi Arabia (latitude: 24°56′52" N, longitude: 45°42′37" E). The plant was identified at the Botany and Microbiology Department of the College of Science at King Saud University in Riyadh, Saudi Arabia... | Results
AgNPs were successfully biosynthesized
The extraction of R. stricta leaves yielded a semi-solid dark green aqueous extract and its alkaline fraction (Dark brown) with yields of 40 g and 30.1g, respectively. Both preparations were light yellow when dissolved in distilled water for AgNPs synthesis. The biosynth... | Discussion and conclusion
Nanotechnology is defined as the creation, display, manipulation, and use of nanoparticles 22 . Nanoparticles have a single dimension ranging from 1 to 100 nm. They have unique properties that set them apart from bulk materials, which might be affected their shape and size 23 . Solar cells, ph... | Discussion and conclusion
Nanotechnology is defined as the creation, display, manipulation, and use of nanoparticles 22 . Nanoparticles have a single dimension ranging from 1 to 100 nm. They have unique properties that set them apart from bulk materials, which might be affected their shape and size 23 . Solar cells, ph... | One of the most promising, non-toxic, and biocompatible developments for many biological activities is the green synthesis of nanoparticles from plants. In this work, we investigated the antifungal activity of silver nanoparticles (AgNPs) biosynthesized from Rhazya stricta aqueous extract against several plant pathog... | Acknowledgements
The authors extend their appreciation to the Deputyship for Research & Innovation “Ministry of Education” in Saudi Arabia for funding this research work through project no. (IFKSUOR3-132-4).
Author contributions
Conceptualization, F.A. and N.M.A.; methodology, S.A.A., R.I.A, and M.A.; software, R.I.A.;... | CC BY | no | 2024-01-16 23:41:59 | Sci Rep. 2024 Jan 14; 14:1297 | oa_package/a9/1a/PMC10788342.tar.gz | |
PMC10788343 | 38221535 | Introduction
The heart is more susceptible to ischemic injury compared to other solid organs because of its innately high metabolic demands. Mitochondria, the organelle vital to cardiomyocytes 1 , continuously supply oxidative energy to maintain heart function. During myocardial injury, mitochondrial impairment is an e... | Materials and methods
Animals
All animal studies were conducted in compliance with the Guide for the Care and Use of Laboratory Animals ( NIH Pub. No. 85-23, revised 1996). The animal protocol was reviewed and approved by the Institutional Animal Care and Use Committee of Indiana University. Male C57BL/6J mice (9–12 w... | Results
Stress-induced mitochondrial dysfunction is associated with reduced Per2 levels in the heart mitochondria and primary cardiomyocytes
Mitochondrial damage is evident following myocardial ischemia. In this study, we first confirmed that the activity of mitochondrial complex-I was severely impaired following ische... | Discussion
Mitochondria are central to heart bioenergetics, as mitochondrial dysregulation is an underlying mechanism of cardiac dysfunction. In this present study, our data clearly demonstrated that: (1) acute stress reduced Per2 levels and concurrently impaired mitochondrial function in the heart mitochondria and adu... | During myocardial injury, inflammatory mediators and oxidative stress significantly increase to impair cardiac mitochondria. Emerging evidence has highlighted interplays between circadian protein—period 2 (Per2) and mitochondrial metabolism. However, besides circadian rhythm regulation, the direct role of Per2 in mitoc... | Supplementary Information
| Supplementary Information
The online version contains supplementary material available at 10.1038/s41598-024-51799-w.
Acknowledgements
We thank the Indiana University Medical Student Program for Research and Scholarship (IMPRS) for supporting medical student research and thank the Hypoxia Core at the Indiana University... | CC BY | no | 2024-01-16 23:41:59 | Sci Rep. 2024 Jan 14; 14:1290 | oa_package/6b/7e/PMC10788343.tar.gz | |
PMC10788344 | 38221550 | Introduction
The development of new and effective substances against pathological bacteria is receiving a great deal of attention since there is a number of concerns about bacterial resistance to various current antibiotics or disinfectants 1 . Although antimicrobial agent resistance has been known for more than 50 yea... | Materials and methodology
Chemicals and materials
CuCl 2 and ZnSO 4 were procured from Sigma Aldrich (UK), NaOH pellets were purchased from Sisco Research Laboratories (Pvt) Ltd, India, PEG was purchased from HiMedia Leading Biosciences Company, Muller Hinton Agar was purchased from HiMedia Laboratories (Germany), Lu... | Results
FT-IR analysis
FT-IR spectra were collected to confirm the coating of PEG to the nanomaterials (supplementary Fig. 1 ). The C-O bond stretching frequency of aliphatic ether of PEG appeared at 1157 cm −1 and the C-H bending of the same appeared at 1458 cm −1 indicating the coating of PEG to the nanomaterials.... | Discussion
Antibacterial activity by agar well diffusion method
The agar well diffusion method was performed to evaluate the antibacterial activity of the synthesized nanocomposites. Based on prior research findings and the preliminary trials conducted, it was found that the inhibition zone is greater in the well-diffu... | Conclusion
PEG functionalized ZnO, Zn:Cu 2:1, Zn:Cu 1:1 and Zn:Cu 1:2 nanomaterials were fabricated by the co-precipitation method and used as antibacterial agents to inhibit the bacterial growth and/or kill the bacteria. The synthesized nanomaterial had inhibitory effects on Gram negative Escherichia coli , Pseudomo... | Polyethyleneglycol-coated biocompatible CuO–ZnO nanocomposites were fabricated hydrothermally varying Zn:Cu ratios as 1:1, 2:1, and 1:2, and their antibacterial activity was determined through the well diffusion method against the Gram-negative Escherichia coli , Pseudomonas aeruginosa , Klebsiella pneumoniae, and ... | Characterization
The XRD patterns were obtained using the D8 Advance Bruker machine, which employs Cu K α (λ = 0.154 nm) radiation, shifting the 2θ from 5° to 80° at a scan speed of 2°/min. The morphology of the produced nanocomposites was evaluated using transmission electron microscopy (TEM). The microscope was run a... | Supplementary Information
The online version contains supplementary material available at 10.1038/s41598-024-52014-6.
Acknowledgements
The authors acknowledge the Sri Lanka Institute of Nanotechnology and the University of Moratuwa for providing the instrument facilities.
Author contributions
Conceptualization, M.J., a... | CC BY | no | 2024-01-16 23:41:59 | Sci Rep. 2024 Jan 14; 14:1293 | oa_package/9f/96/PMC10788344.tar.gz |
PMC10788345 | 38221534 | Introduction
Metagenomics has provided important information on the composition and functional potentials of the gut microbiota and associations between gut bacteria and complex phenotypic traits 1 , 2 . However, in part due to limited availability of cultivated bacterial strains and regulatory issues, causal relations... | Methods
Genome sequencing, assembling, and quality assessment
Whole-genome sequencing was performed using BGISEQ-500 and HiSeq 2000 as described previously 19 . SOAPdenovo (v2.04) 29 was used for de novo assembly of sequencing reads. CheckM (v1.0.13) 30 was used to evaluate the completeness and contamination of genom... | Results
Strains collection and taxonomic information
In this study, we included 76 bacterial strains, comprising 64 unique species from the project of the Culturable Genome Reference version two (CGR2) 4 , 21 deposited in China National GeneBank (CNGB) with accession numbers CNP0000126 and CNP0001833. These strains we... | Discussion
The cPAS-based BGI DNBSEQ sequencer has been commonly used and shown to perform well in eukaryotic genome sequencing 8 and metagenomic sequencing 19 . Considering the increasing demand for cultivated bacterial genome sequencing, the DNBSEQ platform seems as an excellent candidate for bacterial genome resear... | The Illumina HiSeq platform has been a commonly used option for bacterial genome sequencing. Now the BGI DNA nanoball (DNB) nanoarrays platform may provide an alternative platform for sequencing of bacterial genomes. To explore the impact of sequencing platforms on bacterial genome assembly, quality assessment, sequenc... | Supplementary Information
| Supplementary Information
The online version contains supplementary material available at 10.1038/s41598-024-51725-0.
Acknowledgements
This work was supported by grants from National Natural Science Foundation of China (No. 32100009) and the Shenzhen Municipal Government of China (No. XMHT20220104017). We also thank th... | CC BY | no | 2024-01-16 23:41:59 | Sci Rep. 2024 Jan 14; 14:1292 | oa_package/7e/a2/PMC10788345.tar.gz | |
PMC10788346 | 38221518 | Introduction
In recent years, there has been a growing trend towards the use of renewable energy sources and energy efficiency measures in the metallurgical sector to reduce greenhouse gas emissions and mitigate climate change. The metallurgical sector, which includes the production of iron, steel, aluminum, copper, an... | Methodology and measurement results
Under the context of the global energy crisis, the price increase in electricity and imports caused some Albanian metallurgical companies to temporarily interrupt parts of their activities. The energy consumption profile for these three metallurgical companies are shown in the Fig. ... | Methodology and measurement results
Under the context of the global energy crisis, the price increase in electricity and imports caused some Albanian metallurgical companies to temporarily interrupt parts of their activities. The energy consumption profile for these three metallurgical companies are shown in the Fig. ... | Conclusions
This research work demonstrated the importance of implementing renewable energy in the metallurgical sector in Albania. It presented the possibility of implementing wind energy in the metallurgical companies that operate in Albanian for production of steel, aluminum and chromium. The Wind Balkan Atlas (WBA)... | The metallurgical industry, in the context of the global energy crisis and the new European green deal, needs urgent investments on energy and resource efficiency. The metallurgical sector, which includes the production of different metals is an energy-intensive industry that requires large amounts of energy for variou... | Abbreviations
Annual energy produced
Benefit–cost ratio
Balkan Wind Atlas
Capital expenditures
European Wind Energy Association
Geographic Information System
International Energy Agency
International Renewable Energy Agency
Internal rate of return
Levelized cost of electricity
Modern-Era Retrospective Analysis for Rese... | CC BY | no | 2024-01-16 23:41:59 | Sci Rep. 2024 Jan 14; 14:1302 | oa_package/e1/5a/PMC10788346.tar.gz | ||
PMC10788347 | 38221522 | Introduction
Oral and maxillofacial bone defects resulting from many causes, including trauma, tumor removal, periodontitis or peri-implantitis, remain a challenge for clinical orthopedic surgery and oral medicine. When injured, bone tissue undergoes three continuing and overlapping regenerative phases: inflammation, r... | Materials and methods
Materials and reagents
Ammonium hydroxide aqueous solution (NH 3 ·H 2 O, 28%), ethanol, tetraethyl orthosilicate (TEOS), magnesium chloride hexahydrate (MgCl 2 ·6H 2 O) and ammonia chloride (NH 4 Cl) were all purchased from Aladdin Biochemical Technology Co., Ltd. (China), and polyethyleneimine (P... | Results
Fabrication of the MSN+miR-146a complex
The main results of this study are summarized in Fig. 1 . MSNs were obtained after modifying classical monodispersed silica colloidal nanospheres (Fig. 1a ). As shown in Fig. 2a, b , scanning electron microscopy (SEM) and transmission electron microscopy (TEM) images s... | Discussion
In this study, we comprehensively investigated the application potential of the MSN+miR-146a complex in treating irregular bone defects with an inflammatory microenvironment. The biocompatibility and endocytosis ability of pure MSNs have been confirmed in our previous studies. 16 – 18 Here, PEI, a polymer w... | Conclusion
By loading the multifunctional nucleic acid drug miR-146a, the pro-osteogenic nanomaterial MSNs successfully accelerated the osteogenic differentiation of hDPSCs and new bone formation in stimulated infected mouse mandibular bone defects with satisfying immunoregulatory capacity in macrophage polarization. T... | Reconstruction of irregular oral-maxillofacial bone defects with an inflammatory microenvironment remains a challenge, as chronic local inflammation can largely impair bone healing. Here, we used magnesium silicate nanospheres (MSNs) to load microRNA-146a-5p (miR-146a) to fabricate a nanobiomaterial, MSN+miR-146a, whic... | Supplementary information
| Supplementary information
The online version contains supplementary material available at 10.1038/s41413-023-00299-0.
Acknowledgements
This work is supported by the National Key R&D Program of China (No. 2022YFC2402900), the National Natural Science Foundation of China (No. 81991502), the Key Research and Development P... | CC BY | no | 2024-01-16 23:41:59 | Bone Res. 2024 Jan 15; 12:2 | oa_package/c0/85/PMC10788347.tar.gz |
PMC10788348 | 38221551 | Introduction
Systemic lupus erythematosus (SLE) is a multisystem autoimmune disorder with the breakdown in self-tolerance and the generation of autoantibodies. 1 – 3 Double-negative (CD3 + CD4 - CD8 - , DN) T cells, a unique subset of T cells lacking CD4 and CD8 co-receptors, play a significant role in the pathogenesi... | Materials and methods
Mice
We purchased MRL/ lpr and the control MRL/Mpj mice (female, 6 weeks) from SLRC laboratory Animal centre. From 12 weeks to 20 weeks, MLN4924 (15 mg/kg) (MCE) or DMSO were intraperitoneally injected into these mice every 3rd day. The mice status and the deaths were observed and recorded daily.... | Results
Inhibition of neddylation attenuated lupus progression in MRL /lpr mice
To investigate the function of neddylation during lupus, female MRL/ lpr mice with the Fas gene mutation were used. From about 12 weeks of age, MRL/ lpr mice exhibit the expansion of lymphocytes and spontaneously develop SLE-like sympt... | Discussion
SLE is an autoimmune disorder and the underlying causes remains mostly unknown. The abnormal accumulation of DN T cells, which led to the peripheral tolerance defects and systemic damage, is a key pathogenesis of SLE. 4 , 27 Thus, it is necessary to elucidate the mechanisms controlling the homeostasis of DN... | Systemic lupus erythematosus (SLE), a severe autoimmune disorder, is characterized by systemic inflammatory response, autoantibody accumulation and damage to organs. The dysregulation of double-negative (DN) T cells is considered as a crucial commander during SLE. Neddylation, a significant type of protein post-transla... | Supplementary information
| Supplementary information
The online version contains supplementary material available at 10.1038/s41392-023-01709-9.
Acknowledgements
The authors thank Professor Jun Yan from University of Louisville for providing C57BL/6 MRL.Fas lpr mice. We express our gratitude for the exceptional technical support provided by the... | CC BY | no | 2024-01-16 23:41:59 | Signal Transduct Target Ther. 2024 Jan 15; 9:18 | oa_package/f4/d1/PMC10788348.tar.gz | |
PMC10788349 | 38221520 | Introduction
Cancer, a significant class of diseases, ranks among the leading causes of human mortality. This malignant disease now stands as the primary cause of death, second only to cardiovascular and cerebrovascular diseases [ 1 ]. In addition to traditional treatment methods such as surgery, chemotherapy, and radi... | Immunotherapy has rapidly evolved in the past decades in the battle against cancer. Chimeric antigen receptor (CAR)-engineered T cells have demonstrated significant success in certain hematologic malignancies, although they still face certain limitations, including high costs and toxic effects. Natural killer cells (NK... | Facts
As a crucial immune cell type, natural killer (NK) cells function as the “first responders” in the context of cancer development. With the rapid advancement of immunotherapy, particularly in cell therapy, research on NK cells has intensified due to their pivotal role in disease treatment. An increasing number o... | Author contributions
BZ, NY and TR conceived and contributed to the writing of the manuscript. MY, WZ, NL, DW, LJ, NX contributed to the writing of the manuscript. BZ, NY and TR revised and wrote the manuscript. All authors reviewed the manuscript. The authors read and approved the final manuscript.
Funding
This resear... | CC BY | no | 2024-01-16 23:41:59 | Cell Death Dis. 2024 Jan 15; 15(1):50 | oa_package/b6/ed/PMC10788349.tar.gz | ||||
PMC10788350 | 38221543 | Introduction
Engagement with ballistic targets and its challenges
As a result of the development of ballistic missiles as high-speed vehicles, combating these missiles has been the main challenge for air defense systems. The priority of countermeasures against these targets is interception during the boost phase, follo... | IGC background and common methods
Generally, another obstacle is the limited time available during the final phase of engagement. The benefits of IGC include (a) eliminating the inevitable lag between traditional guidance and control loops, resulting in high-speed performance (b) considering interceptor dynamics (like ... | Simulation results
Numerous numerical simulations were performed, and the results are reported in this section to evaluate the performance of the proposed IGC law in conjunction with the thruster and to demonstrate its ability to intercept high-speed and accelerated targets. This section examines various aspects of thi... | The present paper proposes a novel integrated guidance and control (IGC) method for engaging with high-speed targets such as ballistic projectiles. considering an extreme short period of terminal engagement due to high relative velocity between target and interceptor, it is particularly important for IGC law to show de... | Problem formulation
In this section, the mathematical model of the engagement kinematics is derived. Then the nonlinear dynamic model of the interceptor with thruster is used to develop the integrated guidance and control equations in the pitch plane. As mentioned in the previous section, the IGC system is considered i... | Author contributions
A.C. (First Author): Problem formulation, simulation and writing first draft. A.N. (Second Author): Supervision and editing. F.F.S. (Corresponding author): editing and submitting.
Data availability
All data for reproduction of the manuscript results is available in the ’simulation’ section in text.... | CC BY | no | 2024-01-16 23:41:59 | Sci Rep. 2024 Jan 14; 14:1298 | oa_package/27/cb/PMC10788350.tar.gz | ||
PMC10788351 | 38221547 | Introduction
Fe 3 O 4 superparamagnetic nanoparticles (SPMNP) have significant potential applications in various science branches including drug delivery 1 rheological enhancement of fluids 2 , heat generation in magnetic field 3 , 4 and contrast enhancement in magnetic resonance imaging 5 . Magnetic nanoparticles (... | Material and method
Material
Ferric chloride hexahydrate (FeCl 3 .6H 2 O, Titrachem, Iran), ferrous chloride tetrahydrate, (FeCl 2 .4H 2 O, Titrachem, Iran), Ethanol (C 2 H 5 OH, Titrachem, Iran), Ammonia (NH 4 OH Titrachem, Iran), TEOS (Si(OC 2 H 5 ) 4 , Titrachem, Iran) L-Ascorbic acid (C 6 H 8 O 6 , Loba chemie, Ind... | Results and discussion
Nanoparticles’ characterization
The FTIR test results are shown in Fig. 3 , and the peaks were characterized in Table 1 . The common peaks in all spectrums (570 cm –1 and 3300 cm –1 ) belongs to Fe–O (Fe 3 O 4 ) and O–H (H 2 O). H 2 O not only absorbs to the surface of the Fe 3 O 4 molecule, ... | Results and discussion
Nanoparticles’ characterization
The FTIR test results are shown in Fig. 3 , and the peaks were characterized in Table 1 . The common peaks in all spectrums (570 cm –1 and 3300 cm –1 ) belongs to Fe–O (Fe 3 O 4 ) and O–H (H 2 O). H 2 O not only absorbs to the surface of the Fe 3 O 4 molecule, ... | Conclusion
The Neel mechanism on the heating of the nanofluids was investigated successfully and the experimental trends was as the theoretical trend especially in low concentrations (10,000 ppm). Surface modification right after the synthesis of the nanoparticles resulted in agglomeration prevention of the nanoparticl... | The effect of surface modification on enhancing the magnetic heating behavior of magnetic nano fluids were investigated, for this purpose Fe 3 O 4 nanoparticles were synthesized using co-precipitation method and surface modification was done using citric acid, ascorbic acid, tetraethyl orthosilicate (TEOS), polyvinyl ... | Supplementary Information
| Supplementary Information
The online version contains supplementary material available at 10.1038/s41598-024-51801-5.
Acknowledgements
The authors wish to acknowledge the Iran National Science Foundation (INSF), IRAN Nanotechnology Innovation Council and Iranian Central Oil Fields Company for financial support of the r... | CC BY | no | 2024-01-16 23:41:59 | Sci Rep. 2024 Jan 14; 14:1296 | oa_package/bb/9d/PMC10788351.tar.gz |
PMC10788352 | 38221571 | Introduction
The oral cavity is the initial segment of the digestive system, second source of respiration, and a crucial organ for pronunciation, mastication, and facial esthetics. Poor oral health may have an impact on a person’s overall health, causing pain, discomfort, and disfigurement. 1 Oral diseases, such as de... | Early diagnostic methods utilizing exosomes in oral diseases
According to the above, it is convincing that exosomes play a crucial role in the progression of oral diseases. Our particular emphasis lies in exosomal application for early diagnosis due to the potential exacerbation of patients’ suffering caused by delayed... | Conclusions and prospects
Exosomes have emerged as a novel research frontier, with a significant application potential across diverse fields. In the realm of oral medicine, exosomes hold promise as non-invasive biomarkers for early disease diagnosis by distinguishing between pathological and healthy states, with period... | Oral diseases, such as periodontitis, salivary gland diseases, and oral cancers, significantly challenge health conditions due to their detrimental effects on patient’s digestive functions, pronunciation, and esthetic demands. Delayed diagnosis and non-targeted treatment profoundly influence patients’ prognosis and qua... | Exosomes in the progression of oral diseases
As researchers have demonstrated the intricate roles of exosomes in biological events, their distinct alterations are significant components in the pathological processes of oral diseases. At the initial stage, analyzing the exosomal information helps to improve our early aw... | Acknowledgements
This work was supported by the National Natural Science Foundation of China Grants (82370945, 82171001, 82222015 and 82370915). Research Funding from West China School/Hospital of Stomatology Sichuan University (RCDWJS2023-1). Figures were created with BioRender.com.
Author contributions
J.W. and Y.F. ... | CC BY | no | 2024-01-16 23:41:59 | Int J Oral Sci. 2024 Jan 15; 16:4 | oa_package/d5/9a/PMC10788352.tar.gz | ||
PMC10788353 | 37852616 | Introduction
Hypoxia is a state of oxygen deficiency commonly observed in most cancers. Tumor hypoxia causes the formation of blood vessels, enhancing the potential for metastasis. Previous studies revealed that hypoxia strongly induces vascular endothelial growth factor (VEGF) expression [ 1 ]. Angiogenesis is the pro... | Methods
Data collection
Pan-cancer data were downloaded (September 2022) from the UCSC Xena website ( http://xena.ucsc.edu/ ). RNA-sequencing gene expression data (HTSeq-FPKM), micro-RNA (miRNA) expression data, survival data, clinical data, and immune subtypes were obtained from the Cancer Genome Atlas (TCGA) database... | Results
Expression patterns of VEGF family genes
To understand the role of VEGF family genes in human cancers, we examined their expression patterns across 33 cancers. VEGFB has the highest gene expression level, and VEGFD has the lowest gene expression level ( Fig. 1A ). All expression pairs of VEGF family genes s... | Discussion
In this study, we aimed to explore the potential oncogenic roles of VEGF family genes across pan-cancer through sophisticated bioinformatic analyses. We observed heterogeneity in the expression patterns of VEGF family genes across different cancers. Except for CHOL and LIHC, VEGFD was down-regulated in 16 ... | Tumor hypoxia, oxygen deprivation state, occurs in most cancers and promotes angiogenesis, enhancing the potential for metastasis. The vascular endothelial growth factor (VEGF) family genes play crucial roles in tumorigenesis by promoting angiogenesis. To investigate the malignant processes triggered by hypoxia-induced... | This work was supported by the National Research Foundation of Korea (NRF) grant funded by the Korea government (MSIT) (No. 2020R1C1C1012288).
Supplementary Materials
Supplementary data can be found with this article online at http://www.genominfo.org . | CC BY | no | 2024-01-16 23:41:59 | Genomics Inform. 2023 Sep 27; 21(4):e44 | oa_package/0b/4c/PMC10788353.tar.gz | ||
PMC10788354 | 38224715 | Introduction
Liver cancer, a type of carcinoma, has the highest mortality rate in the world each year [ 1 ]. In 2018, there were 841,000 new cases of liver cancer, and the death toll reached 782,000 [ 2 ]. The average incidence of liver cancer and the associated mortality rate can be two to three times higher in men, p... | Methods
In this study, we adopted the method used by Ma’ruf et al. [ 9 ] and Puspitaningrum et al. [ 10 ], as depicted in Fig. 1 . Liver cancer-associated SNPs were obtained from the GWAS Catalog database ( http://www.ebi.ac.uk/gwas ; accessed on 15-02-2023). Subsequently, we performed further analysis using HaploReg ... | Results and Discussion
Identification of genomic variants of liver cancer
This study identified SNPs associated with liver cancer from the GWAS catalog. Of these SNPs, 29 were further confirmed through SNP genotyping, as shown in Table 1 . Subsequently, HaploReg version 4.1 was utilized, applying a p-value threshold o... | Results and Discussion
Identification of genomic variants of liver cancer
This study identified SNPs associated with liver cancer from the GWAS catalog. Of these SNPs, 29 were further confirmed through SNP genotyping, as shown in Table 1 . Subsequently, HaploReg version 4.1 was utilized, applying a p-value threshold o... | Liver cancer is the fourth leading cause of death worldwide. Well-known risk factors include hepatitis B virus and hepatitis C virus, along with exposure to aflatoxins, excessive alcohol consumption, obesity, and type 2 diabetes. Genomic variants play a crucial role in mediating the associations between these risk fact... | CC BY | no | 2024-01-16 23:41:59 | Genomics Inform. 2023 Dec 29; 21(4):e48 | oa_package/8b/36/PMC10788354.tar.gz | |||
PMC10788355 | 38224714 | Introduction
With increasing world population, there is a need to improve food security, which calls for targeted actions to achieve zero hunger under the Sustainable Development Goals adopted by the United Nations in 2015. Currently, fish is the primary source of animal protein for one billion people. Global fish prod... | Methods
Specimen selection and DNA extraction
A full-sib family of silver barb was artificially fertilized and cultured at the Pathum Thani Aquatic Animal Genetics Research and Development Center, Aquatic Animal Genetics Research and Development Division, Department of Fisheries, Ministry of Agriculture and Cooperative... | Results
Determination of the sex system and identification of sex-candidate loci in the silver barb
A total of 20,129 SNP and 17,025 PA loci were examined in 32 individuals, including 16 males and 16 females. The PIC values for SNP loci ranged from 0.03 to 0.50, with an average of 0.22, while those for PA loci ranged f... | Discussion
Latest technologies in aquaculture have been developed from extensive to semi-intensive culture systems on a commercial scale; however, further research is required to enhance production and stock quality while improving fish health management [ 2 ]. One major research area is the chromosome-level manipulati... | Visarut Chailertrit and Thitipong Panthum contributed equally to this work.
Silver barb ( Barbonymus gonionotus ) is among the most economically important freshwater fish species in Thailand. It ranks fourth in economic value and third in production weight for fisheries and culture in Thailand. An XX/XY sex-determinati... | This research was financially supported in part by a Ph.D. Scholarship for Chalermprakiat 70 years of reign under the Agricultural Research Development Agency (Public Organization) (ARDA) and the Royal Golden Jubilee PhD program under the Thailand Research Fund (TRF) and Agricultural Research Development Agency (Public... | CC BY | no | 2024-01-16 23:41:59 | Genomics Inform. 2023 Dec 29; 21(4):e47 | oa_package/2d/a9/PMC10788355.tar.gz | ||
PMC10788356 | 38224712 | Introduction
Nonalcoholic fatty liver disease (NAFLD) is a prevalent form of chronic liver disease that contributes to metabolic disorders and associated health conditions. In recent years, the incidence of NAFLD has risen, surpassing viral hepatitis as the leading chronic liver disease worldwide. NAFLD severity varies... | Methods
Data collection and processing
The mRNA expression data utilized in our study, specifically from datasets GSE49541, GSE48452, and GSE167523, were retrieved from the Gene Expression Omnibus database at NCBI [ 13 ]. The GSE49541 dataset comprises expression data obtained through array profiling, focusing on NAFLD... | Results
DEGs between advanced NAFLD and mild NAFLD
A total of 1,359 DEGs, comprising 600 downregulated and 759 upregulated DEGs in GSE49541, were identified by comparing the transcriptomes of liver tissues from patients with advanced and mild NAFLD ( Fig. 1A ). These DEGs were subsequently utilized for WGCNA and the co... | Discussion
NAFLD is the most common chronic liver disease worldwide, encompassing a spectrum of pathological processes from benign hepatic steatosis to NASH, cirrhosis, and potentially hepatocellular carcinoma [ 21 ]. The progression from simple hepatic steatosis to NASH represents a critical juncture in the evolution ... | Nonalcoholic fatty liver disease (NAFLD) is a common type of chronic liver disease, with severity levels ranging from nonalcoholic fatty liver to nonalcoholic steatohepatitis (NASH). The extent of liver fibrosis indicates the severity of NASH and the risk of liver cancer. However, the mechanism underlying NASH developm... | Supplementary Materials
Supplementary data can be found with this article online at http://www.genominfo.org . | CC BY | no | 2024-01-16 23:41:59 | Genomics Inform. 2023 Dec 29; 21(4):e45 | oa_package/9d/38/PMC10788356.tar.gz | ||
PMC10788357 | 38224716 | Introduction
Technological advancements and improvements in next-generation sequencing have allowed for the exploration of complex and previously unknown marine microbial communities, which constitute the largest and most stable ecosystem on earth. Studies such as the Tara Oceans project [ 1 ] have enabled the discov... | Methods
Metagenomic DNA extraction
The study collected marine sediment samples from 12 locations off the Norwegian coast and metagenomic DNA was extracted using the FastDNA Spin Kit for Soil (MP Biomedicals, California, USA). The DNA samples were sequenced using both HiSeq3000 (Norwegian Sequencing Centre, Oslo, Norway... | Results
Normalization and preprocessing of sequence data
Illumina HiSeq3000 generated a higher number of bases, on average (~36 billion bases and fewer reads ~241 M) than BGISEQ-500 (~32 billion bases or ~322 M reads) at most sample points ( Fig. 2 ). Normalization enabled us to retain ~ 23-38 billion high-quality base... | Discussion
Our study compared the metagenomic DNA sequences generated by two sequencing platforms, HiSeq3000 and BGISEQ-500, from 12 samples collected along the Norwegian coast. To evaluate the quality of the generated datasets, we utilized two different reference databases, taxonomic classifiers and assemblers.
Both p... | Recent advances in sequencing technologies and platforms have enabled to generate metagenomics sequences using different sequencing platforms. In this study, we analyzed and compared shotgun metagenomic sequences generated by HiSeq3000 and BGISEQ-500 platforms from 12 sediment samples collected across the Norwegian coa... | Illumina HiSeq3000 sequencing was performed by the Norwegian Sequencing Centre ( www.sequencing.uio.no ), a national technology platform hosted by the University of Oslo and Oslo University Hospital and supported by the "Functional Genomics" and "Infrastructure" programs of the Research Council of Norway and the Southe... | CC BY | no | 2024-01-16 23:41:59 | Genomics Inform. 2023 Dec 29; 21(4):e49 | oa_package/53/fd/PMC10788357.tar.gz | ||
PMC10788358 | 38224713 | Introduction
Colorectal cancer (CRC) is among the leading causes of cancer-related death, in which colon adenocarcinoma (COAD) is the major type of CRC [ 1 ]. It ranks as the second most common cancer in women and the third most prevalent in men. Men have approximately 25% higher incidence and mortality rates for CRC c... | Methods
Analysis of differential expression of ANO7 gene in COAD and normal tissues
The ANO7 gene expression level in COAD tissue was investigated in comparison to normal tissue using the TCGA-COAD dataset through both the GEPIA2 ( http://gepia2.cancer-pku.cn/ ) [ 12 ] and UALCAN databases ( http://ualcan.path.uab.... | Results
Differential expression of ANO7 gene in COAD and normal tissues
The expression level of ANO7 gene in COAD and normal tissues was explored in the GEPIA2 and UALCAN databases. The data consistently demonstrated a significant decrease in ANO7 mRNA expression in the COAD samples compared to the normal tissues a... | Discussion
ANO7 is recognized as a prostate-specific protein. It has been proposed as both a diagnostic and therapeutic target for prostate cancer [ 8 - 10 , 23 ]. Furthermore, a growing body of evidence has recently demonstrated the pathogenic role of ANO7 in several other cancers, including breast cancer, thyroid can... | Chen Chen and Siripat Aluksanasuwn contributed equally to this work.
Colon adenocarcinoma (COAD) is the predominant type of colorectal cancer. Early diagnosis and treatment can significantly improve the prognosis of COAD patients. Anoctamin 7 (ANO7), an anion channel protein, has been implicated in prostate cancer and ... | This project is funded by National Research Council of Thailand (NRCT) (Grant No. N42A660849) and Mae Fah Luang University.
Supplementary Materials
Supplementary data can be found with this article online at http://www.genominfo.org . | CC BY | no | 2024-01-16 23:41:59 | Genomics Inform. 2023 Dec 29; 21(4):e46 | oa_package/02/6d/PMC10788358.tar.gz | ||
PMC10788359 | 38224717 | Introduction
The coronavirus disease 2019 (COVID-19) pandemic, caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has had a devastating impact on human health and economic activities around the globe [ 1 ]. The virus, which first emerged in late 2019, quickly spread around the world to become a... | Methods
Response variables
The COVID-19 data consists of daily series of confirmed cases, death cases, intensive care unit (ICU) patients, VRs according to the number of inoculations (per hundred people), and the SI of South Korea. All variables were downloaded from Our World in Data (OWID) [ 31 ]. The daily confirme... | Results
EI rate improves COVID-19 prediction accuracy
For the five models (ARIMA, GAM, TSGLM, LightGBM, and Bi-LSTM) the prediction results for the daily confirmed cases for the vaccination lasting period T = 90, using raw data are summarized ( Table 3 ). The covariate combination numbers of Table 3 are in the same... | Discussion
The COVID-19 pandemic represents the biggest global shock in decades that affected all major aspects of life [ 54 , 55 ]. Due to a lack of specific therapeutic agents or effective treatment against COVID-19, the outbreak elicited immense global interest in the development and distribution of safe COVID-19 va... | Vaccine development is one of the key efforts to control the spread of coronavirus disease 2019 (COVID-19). However, it has become apparent that the immunity acquired through vaccination is not permanent, known as the waning effect. Therefore, monitoring the proportion of the population with immunity is essential to im... | This research was supported by research grants from the Ministry of Science and ICT, South Korea (No.2021M3E5E3081425). | CC BY | no | 2024-01-16 23:41:59 | Genomics Inform. 2023 Dec 29; 21(4):e50 | oa_package/39/dc/PMC10788359.tar.gz | ||
PMC10788360 | 38224718 | Introduction
Neoarius is a genus of catfish belonging to the family Ariidae within the order Siluriformes. Currently, it comprises 11 described species distributed in Australia and New Guinea, with conservation status ranging from "least concern" to "vulnerable" according to the International Union for Conservation of... | Methods
For the completion of this study, DNA samples from Neoarius species were collected from muscular tissue and sequenced by Iridian Genomics In platform HiSeq x Ten of Illumina. The resulting sequence data were provided by Dr. Ricardo Betancur through Sequence Read Archive (SRA) files hosted on NCBI ( Table 1 ).... | Results and Discussion
We observed that the mitochondrial genomes have similar characteristics among them. All mitogenomes presented 22 tRNA genes, 13 PCGs, 2 rRNA genes, and a control region called the D-loop, which is consistent with other groups within the same family and even what is typically expected in vertebrat... | Results and Discussion
We observed that the mitochondrial genomes have similar characteristics among them. All mitogenomes presented 22 tRNA genes, 13 PCGs, 2 rRNA genes, and a control region called the D-loop, which is consistent with other groups within the same family and even what is typically expected in vertebrat... | Conclusion
The mitochondrial genomes of the studied species showed many similarities in terms of size, composition, and nucleotide percentage. Despite their stable organization, the mitogenomes proved to be valuable in understanding the molecular evolution of these eight species belonging to the Neoarius genus. New s... | The genus Neoarius , known as marine catfish, is a group of the family Ariidae, composed of 10 species found in Oceania. None of the species in this genus have their mitochondrial genome described, which is highly valuable in phylogenetic and molecular evolution studies. For the present work, eight species from the N... | Supplementary Materials
Supplementary data can be found with this article online at http://www.genominfo.org . | CC BY | no | 2024-01-16 23:41:59 | Genomics Inform. 2023 Dec 29; 21(4):e51 | oa_package/e0/9c/PMC10788360.tar.gz | |
PMC10788361 | 38224719 | Introduction
The development of the digital polymerase chain reaction (PCR) method, third-generation PCR equipment, has recently changed the research trend of the existing microbial molecular diagnosis field. Especially, a new digital PCR equipment ‘LOAA (Lab On An Array) digital real-time PCR analyzer (Optolane, Seong... | Methods and Results
Particular bacterial species-specific primer and probe sets design method
In this study, we tried to verify the detection and quantification efficiency of digital PCR equipment for specific bacterial species within the unstable template mDNA sample. Therefore, for this verification, we selected S. ... | Methods and Results
Particular bacterial species-specific primer and probe sets design method
In this study, we tried to verify the detection and quantification efficiency of digital PCR equipment for specific bacterial species within the unstable template mDNA sample. Therefore, for this verification, we selected S. ... | Discussion
The digital PCR platform is spotlighted as third-generation PCR equipment that can absolutely quantify the copy number of a particular gene to be identified within the sample without calculating a separate standard curve [ 15 ]. However, due to the high-cost burden of consumables of digital PCR, consumers’ c... | Dongwan Kim, Junhyeon Jeon, and Minseo Kim contributed equally to this work.
Accurate and efficient microbial diagnosis is crucial for effective molecular diagnostics, especially in the field of human healthcare. The gold standard equipment widely employed for detecting specific microorganisms in molecular diagnosis is... | This research was supported by Basic Science Research Capacity Enhancement Project through Korea Basic Science Institute (National Research Facilities and Equipment Center) grant funded by the Ministry of Education (Grant No. 2019R1A6C1010033). This study has been done with the participation of undergraduate students w... | CC BY | no | 2024-01-16 23:41:59 | Genomics Inform. 2023 Dec 29; 21(4):e52 | oa_package/4c/4d/PMC10788361.tar.gz | ||
PMC10788362 | 0 | The launch of a new section of Computational and Structural Biotechnology Journal covering the breath of Nanoscience and Advanced Materials (NAM) provides a unique platform for reporting experimental and computational studies on the exciting science that occurs at the interface between engineered and manufactured mater... | CC BY | no | 2024-01-16 23:41:59 | Comput Struct Biotechnol J. 2023 Dec 14; 25:1-2 | oa_package/43/b3/PMC10788362.tar.gz | |||||||
PMC10788384 | 38226359 | INTRODUCTION
The global population's growth and aging contribute to a heightened incidence of wounds, including those that become infected. 1 Infections within wounds pose a substantial hindrance to the healing process, significantly impeding the transition from the inflammatory phase to the proliferative phase. T... | MATERIAL AND METHODS
Study group
The study group included twenty 18–85 years old patients with pressure ulcers, diabetic ulcers, trauma wounds, or postoperation wounds with wound areas of 2–30 cm 2 . Out of the 20 patients that were recruited, 15 patients completed the study protocol and their data were analyzed. Three... | RESULTS
Two patients suffered from two wounds each, and thus 17 wounds were analyzed. All wounds were noninfected as determined by clinical examination. Table 3 describes the wound parameters at the start of the study. Nine of the wounds were post‐op wounds following amputation below the knee, two of which were follo... | DISCUSSION
While silver and copper have wide spectrum antimicrobial properties, as opposed to silver, copper is a trace mineral essential for the normal function of all human tissues. 23 In wounds, copper is involved in many of the wound healing processes, such as angiogenesis, stimulation of secretion of fibrinog... | CONCLUSION
The results of this study confirm other clinical case reports showing enhanced wound healing of hard‐to‐heal wounds with copper dressings, both of infected and noninfected wounds. Further studies should be conducted to further support the clinical benefit of using copper dressings instead of silver dressings... | Abstract
Background and Aims
Dressings containing silver ions are an accepted and common option for wound treatment. However, some wounds fail to heal at the desired rate despite optimal management. The aim of the study was to examine the effect of copper dressings in noninfected wounds.
Methods
The study included 20 p... | AUTHOR CONTRIBUTIONS
Oxana Gorel : Conceptualization; data curation; formal analysis; investigation; project administration; supervision; writing—review & editing. Irit Kucyn‐Gabovich : Conceptualization; methodology; project administration; data curation; writing. Monza Hamuda and Ilana Feldman were involved in the... | ACKNOWLEDGMENTS
The authors would like to thank MedCu Technologies for donating the copper wound dressings.
DATA AVAILABILITY STATEMENT
The data that support the findings of this study are available from the corresponding author upon reasonable request. O.G. had full access to all of the data in this study and takes co... | CC BY | no | 2024-01-16 23:42:00 | Health Sci Rep. 2024 Jan 14; 7(1):e1816 | oa_package/77/ba/PMC10788384.tar.gz |
PMC10788385 | 38204385 | This time of the year brings a sense of excitement, as various dictionaries announce the ‘Word of the Year’ that marks our preoccupations, curiosity, and reflects our ethos. Although several dictionaries announced words related to the proliferation of artificial intelligence (AI), e.g., hallucination [ 1 ], two major... | CC BY | no | 2024-01-16 23:42:00 | Korean J Women Health Nurs. 2023 Dec 31; 29(4):253-256 | oa_package/16/87/PMC10788385.tar.gz | |||||||
PMC10788386 | 38204394 | Introduction
In 2021, the number of deaths in South Korea (hereafter, Korea) reached 317,680, a 4.2% increase from the previous year, reaching its highest level in the past decade [ 1 ]. The suicide rate was 26.0 (the number of deaths per 100,000 population), up 1.2% from the previous year [ 1 ]. Moreover, Korea record... | Methods
Data sources
This study used cause-of-death statistics from Statistics Korea to analyze trends in suicide deaths among Korean women. The cause-of-death statistics were compiled based on death certificates collected by Statistics Korea. In this study, microdata on cause of death statistics from 2011 to 2021 were... | Results
In 2021, the number of suicide deaths in Korean men and women reached 13,352, an increase of 157 (1.2%) compared with the previous year, with a suicide rate of 26.0 per 100,000 population ( Table 1 ). The suicide rate peaked at 31.7 per 100,000 population in 2011 and then showed a declining trend for 6 years. H... | Discussion
The gender ratio of suicide rates has decreased, indicating a relatively higher increase of suicide deaths in Korean women compared with men [ 1 ]. Furthermore, in 2021, the women’s suicide death rate reached 16.2 per 100,000 population, a significant increase of 1.4% from the previous year [ 1 ].
The foreig... | Purpose
This study aims to analyze the number of suicide deaths in women, trends in suicide mortality, characteristics of suicide by age, and outcomes of suicide means over the past decade (2011–2021) in South Korea.
Methods
Using cause of death data from Statistics Korea, an in-depth analysis of Korean women’s suicide... | CC BY | no | 2024-01-16 23:42:00 | Korean J Women Health Nurs. 2023 Dec 31; 29(4):348-356 | oa_package/fb/9b/PMC10788386.tar.gz | |||
PMC10788387 | 38204393 | Introduction
Endocrine-disrupting chemicals (EDCs) are compounds that interfere with normal hormone function. They are primarily synthesized for industrial solvents, electronics, personal care products, plastics, and pesticides, and they include polychlorinated biphenyls, bisphenol A, phthalates, dioxins, DDT (dichloro... | Methods
Design
This study used an exploratory qualitative design to explore the perception of mothers with young children about EDCs for their concerns, the issues they faced, and the way they dealt with them. This study adhered to the COREQ (Consolidated Criteria for Reporting Qualitative Research) guidelines ( https:... | Results
The general characteristics of the 12 mothers are presented in Table 1 .
The average age was 34.3 years (range: 23–41 years), and the average number of children was 1.6 (range: 1–3). In terms of financial status, 11 mothers (91.7%) considered themselves middle-class, and six mothers (41.7%) were employed. Two ... | Discussion
The study explored the perceptions about EDCs from the perspectives of mothers with young children using qualitative content analysis. Exposure to EDCs is known to occur through food, water, dermal contact, and inhalation [ 17 ], and the mothers in this study accurately recognized the transmission routes of ... | Purpose
Despite the health impacts of endocrine-disrupting chemicals (EDCs) beginning in the early stages of life, there is little research on the perception of EDCs among Korean mothers, who are primarily responsible for protecting children. This study aimed to explore how mothers with young children perceived EDCs fo... | CC BY | no | 2024-01-16 23:42:00 | Korean J Women Health Nurs. 2023 Dec 31; 29(4):337-347 | oa_package/78/71/PMC10788387.tar.gz | |||
PMC10788388 | 38204392 | Introduction
Sarcopenia is one of the diseases that degrade the health-related quality of life (HRQoL) of older adult women and the decrease in muscle mass due to aging is one of the representative changes [ 1 ]. Sarcopenia causes musculoskeletal diseases (e.g. falls and fractures), depression, or cognitive decline. In... | Methods
Research design
This study is a descriptive correlational study conducted to identify factors influencing HRQoL in older adult women with sarcopenia in Korea, analyzing the 8th Korea National Health and Nutrition Examination Survey (KNHANES) 2019 data. This study was described in accordance with the STROBE guid... | Results
Participants’ general characteristics
The mean age of the 142 participants was 72.77 years (SE, 0.57), and 51.3% were over 75 years of age. Overall, 72.3% of participants were unemployed and 54.2% were in the lower household income group. Regarding biological function, the most prevalent disease was osteoporosi... | Discussion
Regarding functional status, difficulty working had the greatest impact on the HRQoL of older adult women with sarcopenia. Working not only improves economic status but also self-esteem and QoL for older adult women with sarcopenia [ 18 ]. This may be because self-esteem increases through social ties and rol... | This article is based on the master’s thesis of the first author (Sol Hyun Lee) from Jeonbuk National University.
Purpose
This study aimed to identify factors influencing the health-related quality of life (HRQoL) of older adult women with sarcopenia.
Methods
The study was secondary data analysis using data from the 20... | CC BY | no | 2024-01-16 23:42:00 | Korean J Women Health Nurs. 2023 Dec 31; 29(4):328-336 | oa_package/dd/b9/PMC10788388.tar.gz | |||
PMC10788389 | 38204390 | Introduction
In South Korea (hereafter, Korea), there is a trend towards delayed marriages, resulting in an average age of 33.4 years for first-time mothers in 2021. Furthermore, the percentage of mothers of advanced maternal age, defined as 35 years or older, is 33.8% [ 1 ]. A report from the World Health Organization... | Methods
Study design
This study used structural equation modeling to construct a hypothetical model explaining QoL in high-risk pregnant women based on Roy’s adaptation model [ 17 ] and previous research. The study is described according to the STROBE (Strengthening the Reporting of Observational Studies in Epidemiolog... | Results
Differences in quality of life according to participants’ characteristics
The mean age of the study participants was 35.29 (±3.72) years, ranging from 26 to 45 years, and the majority (51.1%) were under 35 years old (n=170). Most participants had a college degree (n=299, 89.8%), 58.6% (n=195) reported not havin... | Discussion
This study constructed a hypothetical model based on Roy’s adaptation theory [ 17 ] and informed by concepts from literature reviews, to elucidate the QoL in high-risk pregnant women. We then tested the model’s adequacy and the significance of its pathways using a sample of 333 high-risk pregnant women. Fact... | This article is based on the doctoral dissertation of the first author (Mihyeon Park) from Chungnam National University.
Purpose
This study aimed to develop and validate a structural model for the quality of life (QoL) among high-risk pregnant women, based on Roy’s adaptation model.
Methods
This cross-sectional study c... | Supplementary materials
Further details on supplementary materials are presented online (available at https://doi.org/10.4069/kjwhn.2023.11.13.1 ). | CC BY | no | 2024-01-16 23:42:00 | Korean J Women Health Nurs. 2023 Dec 31; 29(4):302-316 | oa_package/82/2c/PMC10788389.tar.gz | ||
PMC10788390 | 38204386 | Background
Approximately 36% of all cancer patients in Korea receive radiotherapy, a key modality of cancer treatment alongside surgery and chemotherapy. Diverse therapeutic techniques have resulted from advances in radiological technology and treatment devices, contributing to the improvement of the quality of treatme... | Conclusions
As radiotherapy techniques for gynecologic cancer become increasingly sophisticated and varied, the role of radiotherapy in cancer treatment is expanding. While the primary focus used to be on treatment outcomes, there is now a growing interest in the various issues experienced during the cancer survival pe... | Latest trends in radiotherapy
Radiotherapy aims to maximize treatment effectiveness and minimize side effects by primarily irradiating tumor tissues and limiting radiation exposure to the surrounding normal tissues. Radiotherapy technology has advanced dramatically over the last 20 years, and the effectiveness of conco... | CC BY | no | 2024-01-16 23:42:00 | Korean J Women Health Nurs. 2023 Dec 31; 29(4):257-262 | oa_package/b2/54/PMC10788390.tar.gz | |||||
PMC10788391 | 38204391 | Introduction
The human papillomavirus (HPV), which is primarily transmitted through sexual contact, has been recognized as a significant cause of cervical cancer [ 1 ]. To date, more than 200 types of HPV have been identified [ 2 ], with high-risk strains such as HPV-16 and HPV-18 being strongly linked to genital cance... | Methods
Research design
The purpose of this descriptive correlational study was to identify factors influencing the intention to engage in cervical cancer preventive behavior among women infected with HPV. This study adhered to the STROBE reporting guidelines ( https://www.strobe-statement.org/ ).
Participants
This stu... | Results
Differences in cervical cancer preventive behavior intentions based on general and human papillomavirus-related characteristics
The average age of the participants was 37.96±9.31 years. Among them, 84 individuals (65.1%) were married, with the most common level of education being a bachelor’s degree or higher, ... | Discussion
This study aimed to assess the levels of cervical cancer and HPV-related knowledge, self-efficacy, and uncertainty among women infected with HPV, as well as the factors influencing their intention to engage in cervical cancer preventive behavior, with the goal of developing programs to increase such intentio... | Purpose
This study investigated the influence of cervical cancer knowledge, human papillomavirus (HPV) knowledge, self-efficacy, and uncertainty on the intention to engage in cervical cancer preventive behavior in HPV-infected women.
Methods
This descriptive correlational study was conducted among 129 adult women aged ... | CC BY | no | 2024-01-16 23:42:00 | Korean J Women Health Nurs. 2023 Dec 31; 29(4):317-327 | oa_package/b4/43/PMC10788391.tar.gz | |||
PMC10788392 | 38204389 | Introduction
According to guidelines from the Centers for Disease Control and Prevention (CDC), all women with the potential to bear children should consume 400 μg of folic acid daily, starting at least 1 month before pregnancy and continuing until 3 months into pregnancy. This is to prevent fetal neural tube defects, ... | Methods
Study design
This cross-sectional survey study sought to examine the intake of folic acid and knowledge about folic acid among pregnant women in China and explore the influence of folic acid knowledge on effective folic acid intake.
Participants
This study included women who were at least 12 weeks pregnant and ... | Results
Characteristics of participants
The mean age of the 140 participants was 31.56±3.88 years (range, 21–41 years). In terms of education, 67.9% of the participants held university degrees, and 89.3% were employed. Among the participants’ spouses, 67.1% held university degrees, and 97.9% were employed.
Sixty percen... | Discussion
This study is the first, to our knowledge, to examine the status of effective folic acid intake and investigate its relationship with folic acid knowledge, in line with the four criteria set by the CDC’s folic acid intake guidelines. Our findings indicate that the rate of effective folic acid intake, based o... | Purpose
This study aimed to investigate the current status of effective folic acid intake and the level of folic acid knowledge of Chinese pregnant women and to analyze the relationship between effective folic acid intake and folic acid knowledge.
Methods
From November 2021 to May 2022, 140 pregnant women at Yantai Yuh... | CC BY | no | 2024-01-16 23:42:00 | Korean J Women Health Nurs. 2023 Dec 31; 29(4):291-301 | oa_package/5a/26/PMC10788392.tar.gz | |||
PMC10788393 | 38204388 | Introduction
During pregnancy, women undergo unique physiological, psychological, and social changes. They are exposed to a considerable amount of visible and potential stress, which can make them more susceptible to depression and anxiety [ 1 ]. Before the outbreak of the coronavirus disease 2019 (COVID-19) prenatal s... | Methods
Research design
This cross-sectional, correlational study aimed to investigate the impact of prenatal education characteristics, pandemic-related pregnancy stress, and pregnancy healthcare practice behaviors on prenatal depression during the COVID-19 pandemic. This study adhered to the STROBE (Strengthening the... | Results
General, obstetric, and prenatal education characteristics of participants
Table 1 presents the general, obstetric, and prenatal education characteristics of the 180 participants. The average age of the participants was 32.22±2.86 years. A significant majority, 156 participants (86.7%), reported no job loss, w... | Discussion
The present study found that 49.4% of pregnant women experienced prenatal depression, as determined by a score of 10 or higher on the K-EPDS. This rate aligns with a previous study [ 26 ] conducted during the COVID-19 pandemic, which reported a high prevalence of 56.3% using the same tool and criteria. This ... | Purpose
This study investigated the effects of prenatal education characteristics, pandemic-related pregnancy stress, and health behaviors during pregnancy on prenatal depression in pregnant women during the coronavirus disease 2019 (COVID-19) pandemic.
Methods
The participants were 180 pregnant Korean women, recruited... | CC BY | no | 2024-01-16 23:42:00 | Korean J Women Health Nurs. 2023 Dec 31; 29(4):274-290 | oa_package/68/9e/PMC10788393.tar.gz | |||
PMC10788394 | 38204387 | Introduction
Since South Korea’s total fertility rate dropped below the replacement level of two children per woman in 1985, it has fluctuated between one and just under two. In 2008, the rate was 1.19, but it reached a historic low of 0.92 in 2019, followed by 0.78 in 2022. The number of births in 2022 was particularl... | Methods
Study design
This study employed a descriptive correlational research design to assess the perception and performance of midwives’ roles among midwives and nurses. The structure and content of this study are described following research reporting guidelines, adhering to the order of the STROBE checklist ( https... | Results
General characteristics of participants
Among the 243 participants, there were 79 midwives (11.7% of 677 registered midwives) and 164 nurses (non-midwives). The average age of the midwives was 46.0 years, compared to 38.2 years for the nurses. The largest age group for both the midwives and nurses was those in ... | Discussion
In terms of the importance of the seven areas of midwives’ roles, midwives prioritized antenatal care as the most crucial role, followed by intrapartum care and postpartum care. In contrast, nurses perceived neonatal care as the most important role of midwives, followed by psychological support for changes a... | Purpose
This study aimed to identify the perceptions, importance, and performance of midwives’ roles among midwives and nurses in Korea.
Methods
A descriptive correlational design was employed. Data were collected from 164 nurses and 79 midwives from April 1 to June 25, 2021. Midwives enrolled in the Korean Midwifery A... | CC BY | no | 2024-01-16 23:42:00 | Korean J Women Health Nurs. 2023 Dec 31; 29(4):263-273 | oa_package/8f/b6/PMC10788394.tar.gz | |||
PMC10788397 | 38225938 | Discussion
Although fluorescein angiography still represents the gold standard to make diagnosis of PDR, the introduction of new wide – field OCTA devices has provided a great support in daily clinical practice, performing even more detailed exams, with no dye injection. 1 Until a few years ago, only low resolution im... | Conclusion
In our view, in the near future, PDR diagnosis would be easily performed with more advanced wide – field OCT – Angiography devices, which would permit to highlight even the smallest microvascular changes. | Keywords | Case report
A 58-year-old male patient, suffering from type 2 diabetes mellitus, referred our center because of vitreous hemorrhage in the right eye (RE) due to florid proliferative diabetic retinopathy (PDR). The patient underwent a complete ophthalmological examination of the left eye (LE), comprehensive of best corr... | Acknowledgment
The authors want to thank Marta Migliorati for performing the image acquisition. The authors want to thank ERA-NET NEURON (NEURON-066 Rethealthsi) for research support. | CC BY | no | 2024-01-16 23:42:00 | Am J Ophthalmol Case Rep. 2023 Dec 18; 33:101976 | oa_package/83/b5/PMC10788397.tar.gz | |||
PMC10788399 | 38226033 | Background
This database was created as part of a study whose purpose is to determine the photovoltaic potential, which in turn will allow estimating the agrivoltaic potential of the region [1] , [2] , [3] . This analysis was done considering the traditional periods of crops in the region and the photovoltaic potent... | Experimental Design, Materials and Methods
The database presented in this research was obtained from a public database belonging to the Yaqui River irrigation district ( http://www.dryaqui.org.mx/drrymet/dashboard ), which is continuously monitored through 21 weather stations. The database originally contains 11 variab... | The adequate records of climatological variables, especially temperature and radiation, constitute the basis to be able to determine the photovoltaic and agrivoltaic potential of a region, for this purpose, the data collected must be extremely precise, so it is required that they be focused, current and reliable, to ha... | Specifications Table
Value of the Data
• This dataset provides climate records over three years for the region that can be used by other researchers to carry out all kinds of statistical analysis. • Data corresponding to solar radiation, temperature and humidity is required to be accurate, due to the large size of th... | Data Availability
Replication data for Photovoltaic energy estimation for the Yaqui Valley, Sonora, México (Original data) (Dataverse).
Acknowledgment
None.
Declaration of Competing Interest
The authors declare that they have no known competing financial interests or personal relationships that could have appeare... | CC BY | no | 2024-01-16 23:42:00 | Data Brief. 2023 Dec 16; 52:109983 | oa_package/3e/e9/PMC10788399.tar.gz | |||
PMC10788401 | 38226254 | Introduction
The coil embolization imposes a comparatively reduced physical burden on the patient when compared with surgical clipping; however, the notable concerns encompass recanalization and the necessity for subsequent aneurysm retreatment [ 1 , 2 ]. Previous studies have observed recanalization in approximately 1... | Method
Patients
Definitions of recanalized/stable aneurysms and the inclusion criteria of patients could be found in our previous works [ 1 , 2 , 8 , 9 ]. The final analysis included a cohort of 66 intracranial aneurysms derived from 65 patients who underwent endovascular treatment for aneurysms within the timeframe of... | Results
Statistical analysis for patient population
The patient characteristics for each group are detailed in Table 2 . No statistically significant differences were observed in age, aneurysm locations, gender distribution or rupture status between the two groups.
Statistical analysis for hemodynamic and morphologica... | Discussion
This study compared the performance of predictive models based on UP and LR using 91 spatiotemporal features derived from seven hemodynamic parameters. The results of UP showed a wide range of AUROC values (ranging from 0.224 to 0.747) for different spatiotemporal hemodynamic features. Notably, 22 pairs of f... | Conclusion
The study demonstrated that the model performance in predicting aneurysm recanalization was significantly influenced by the spatiotemporal characteristics of hemodynamic parameters. PD ave,q1 was the strongest UP. The performance of LR model was enhanced by incorporating multiple features to describe tempor... | Purpose
Hemodynamics play a key role in the management of cerebral aneurysm recanalization after coil embolization; however, the most reliable hemodynamic parameter remains unknown. Previous studies have explored the use of both spatiotemporally averaged and maximal definitions for hemodynamic parameters, based on comp... | Limitations
First, this study involved a cohort of 65 patients. Future steps will encompass an expanded analysis with a larger patient cohort for further evaluation. Second, given its retrospective nature, subsequent research should focus on a prospective study involving a comprehensive cohort covering all types of ane... | Supplementary data
The following is the Supplementary data to this article. | CC BY | no | 2024-01-16 23:42:00 | Heliyon. 2023 Dec 20; 10(1):e22801 | oa_package/5a/5d/PMC10788401.tar.gz |
PMC10788402 | 38226036 | Background
Giant clams (Tridacninae) are iconic reef dwellers that fulfil critical ecological roles in tropical coral reef communities [2] . They also serve as ultra-high-resolution bioarchives to reconstruct past oceanographic conditions in tropical regions, where instrumental records are lacking [3] . Increased und... | Experimental Design, Materials and Methods
Sample preparation
Two modern giant clam shells, T. squamos a (fluted giant clam) and H. hippopus (bear paw clam) were collected from Darvel Bay (4° 51′ 57.2328′′ N, 118° 11′ 34.8864′′ E; 4° 58′ 57.684′′ N, 118° 21′ 42.5268′′ E respectively) within the Coral Triangle region... | This article provides novel data on the microstructure and crystallographic texture of modern giant clam shells ( Tridacna squamosa and Hippopus hippopus ) from the Coral Triangle region of northeast Borneo. Giant clams have two aragonitic shell layers—the inner and outer shell layer. This dataset focuses on the inne... | Specifications Table
Value of the Data
• This dataset provides characterization of the microstructure and crystallographic texture of the shells of two species of giant clam (Tridacna squamosa; Hippopus hippopus). These data are necessary for understanding shell growth and biomineralization mechanisms in the fields o... | Data Availability
Microstructure and crystallographic texture data from modern giant clam shells (Tridacna squamosa and Hippopus hippopus) (Original data) (Mendeley Data).
Acknowledgments
Thanks to the Borneo Marine Research Institute (University Malaysia Sabah) for hosting our research and Dominic Monteroso (Darv... | CC BY | no | 2024-01-16 23:42:00 | Data Brief. 2023 Dec 14; 52:109947 | oa_package/d8/2b/PMC10788402.tar.gz | |||
PMC10788405 | 38225980 | Introduction
Minocycline is a broad-spectrum antibiotic agent with an antiinflammatory activity frequently used in dermatology. 1 , 2 , 3 , 4 The notable efficacy and favorable safety profile of minocycline have made it a preferred choice primarily for treating acne and various other dermatological conditions, ofte... | Discussion
Drug-induced hyperpigmentation has been representing 10% to 20% of reported cases of acquired hyperpigmentation. 5 Among the various medications associated with the development of drug-induced hyperpigmentation, minocycline is frequently reported as an agent. However, it is important to note that only up to... | Conclusion
Our case series presents the first documented instance of successful treatment of minocycline-induced hyperpigmentation utilizing a 730 nm wavelength Ti:sapphire picosecond-domain laser. This remarkable finding highlights the potential significance of picosecond-domain lasers as a valuable addition to the th... | Key words
Abbreviations used
minocycline-induced pigmentation
neodymium:yttrium-aluminum-garnet | Patient 1
A 71-year-old woman with Fitzpatrick skin type I and a history of acne scaring presented to our clinic with gradual onset of diffuse, brown, symmetric hyperpigmentation predominantly in the sun-exposed areas her face, developing over the course of 2 to 3 years. She had been taking minocycline to treat acne vu... | CC BY | no | 2024-01-16 23:42:00 | JAAD Case Rep. 2023 Nov 30; 43:62-68 | oa_package/9a/57/PMC10788405.tar.gz | |||
PMC10788406 | 38043604 | Introduction
Cognitive decline ranges from the minimal decline that is associated with normal aging to dementia. In between these 2 extremities, Mild Cognitive Impairment corresponds to an intermediate stage [ 1 ]. With an overall prevalence of Mild Cognitive Impairment worldwide assessed at 15.6 % in 2022 and an estim... | Methods
The protocol was registered with the International PROSPERO with the registration number CRD42020192395 and adhered to the PRISMA [ 20 ].
Literature search
We conducted a comprehensive literature search in cooperation with an experienced medical information specialist in Embase.com (Elsevier), Medline (Ovid),... | Results
The systematic search identified 3663 records ( Figure 1 ), and 1 additional article was retrieved through reference list scanning. After removing duplicates, we screened 2299 records, of which 2253 were excluded based on title and abstract screening. We retrieved 46 full-text articles for evaluation. We exclud... | Discussion
This systematic review and meta-analysis identified 15 prospective observational studies involving >300,000 participants. Results suggest that dairy might be associated with a lower risk of cognitive decline or dementia but that there may be differences by sex, age, region of origin, level of intake, and typ... | FV and TF shared the first authorship.
Dairy intake may influence cognition through several molecular pathways. However, epidemiologic studies yield inconsistent results, and no dose-response meta-analysis has been conducted yet.
Therefore, we performed a systematic review with a dose-response meta-analysis about the a... |
Author contributions
The authors’ responsibilities were as follows – POC-B: designed the study with feedback from NR, MV, and CDG; DK-H: prepared the literature search; FV and TF: conducted the systematic review and selected of the articles, with feedback from POC-B; FV and NO: performed the risk of bias assessment... | Supplementary data
The following is the Supplementary data to this article: | CC BY | no | 2024-01-16 23:42:00 | Adv Nutr. 2023 Dec 1; 15(1):100160 | oa_package/b3/4d/PMC10788406.tar.gz | |
PMC10788408 | 38142636 | Introduction
Migraine is the second cause of disability worldwide. 1 A small, yet undefined proportion of individuals with migraine experiences disabling attacks that acute and preventive strategies fail to control. These individuals have resistant or refractory migraine depending on the number of unsuccessful prevent... | Conclusions
Treatment-related and individual factors might lead an individual with migraine to a resistant form, still treatable with specific drugs, or a refractory form, that cannot be managed satisfactorily with any treatment. Individuals with resistant or refractory migraine should be referred to expert headache ca... | Summary
Migraine is a leading cause of disability worldwide. A minority of individuals with migraine develop resistant or refractory conditions characterised by ≥ 8 monthly days of debilitating headaches and inadequate response, intolerance, or contraindication to ≥3 or all preventive drug classes, respectively. Resist... | Epidemiology
Given the recency of definitions of resistant and refractory migraine, the epidemiology of those conditions has not been systematically explored. Resistant and refractory migraine are expected to be rare in the general population, but frequent in headache centres. An international survey showed that indivi... | Acknowledgements
We thank Dr Alexis George for the contribution to the “Behavioural therapies” section of this work. We used BioRender to create the figures: BioRender.com. The Authors received no funding for the present manuscript. | CC BY | no | 2024-01-16 23:42:00 | eBioMedicine. 2023 Dec 23; 99:104943 | oa_package/76/12/PMC10788408.tar.gz | |||
PMC10788422 | 38225977 | Introduction
With approximately 18% of effective playing time spent in high-intensity skating activities, performance in ice hockey is a combination of short bouts of explosive and powerful movements cumulating in high energetic demands ( 1 ). The ability to skate and accelerate at higher speeds distinguishes the best ... | Methods
Participants
Every spring, the Quebec Ice Hockey Federation invites the most promising players (men and women) to development camps. Invitations are based on the performance of players during the regular season. Among these invited players, the best will be part of the team competing at the national level. In t... | Results
Associations between F – V mechanical capabilities and anaerobic capacities
Partial Pearson's correlation coefficients suggest that F 0 had a small association with the relative peak power ( r = 0.26, p = 0.049) of the WAnT and was moderately associated with total time ( r = −0.32, p = 0.012) and best... | Discussion
The relevance of F – V athlete profiling has emerged over the last decade. However, little is known about its associations with physical attributes that require high-intensity efforts, such as anaerobic capacities. Considering the importance of such qualities to excel in ice hockey, a deeper understanding ... | Conclusion
This research provides a deeper understanding of underlying associations between the sprinting F – V and anaerobic capacities of highly trained adolescent male and female ice hockey players. Pooled data demonstrated that the ability to apply force at low and high velocities are determinant for anaerobic pe... | Edited by: Jeppe Foged Vigh-Larsen, University of Southern Denmark, Denmark
Reviewed by: Jean Romain Riviere, Université Savoie Mont Blanc, France
Christopher Kirk, Sheffield Hallam University, United Kingdom
Introduction
Sprinting ability and anaerobic capacities are the determinant variables of the performance of ... | Acknowledgments
The authors wish to thank the players who participated in this study and the staff of Hockey Quebec for their collaboration during the planning and execution of testing.
Data availability statement
The raw data supporting the conclusions of this article will be made available by the authors, without und... | CC BY | no | 2024-01-16 23:42:01 | Front Sports Act Living. 2023 Dec 12; 5:1258497 | oa_package/77/34/PMC10788422.tar.gz | |
PMC10788423 | 0 | Introduction
Creating and maintaining talented labor is a priority for any organization, and forensic laboratories are no exception. One of the four goals in the National Institute of Justice's (NIJ) Strategic Research Plan is to “cultivate a diverse and highly skilled workforce” [ 1 ]. This plan acknowledges the impor... | Methods
The NYSP CLS developed the Forensic Investigative Curriculum (FIC) School educational outreach initiative to provide students with more information about forensic science careers. The program is designed to have scientists, students, and professors meet several times per college semester, with each meeting focu... | Results and discussion
The Forensic Outreach concept has the potential to leverage the NYSP CLS scientific expertise and infrastructure with educational institutions and, eventually, with private industry to create a unique partnership to develop new analytical methods and technologies while enhancing educational oppor... | Results and discussion
The Forensic Outreach concept has the potential to leverage the NYSP CLS scientific expertise and infrastructure with educational institutions and, eventually, with private industry to create a unique partnership to develop new analytical methods and technologies while enhancing educational oppor... | Conclusions
The novel Educational Outreach Initiative and FIC School program created several avenues of outreach and growth to NYSP CLS staff and aspiring forensic scientists. The FIC School supported outreach and recruitment efforts of appropriately qualified candidates. Accreditation requirements are very specific re... | Skills and knowledge gaps frequently exist between forensic educational programs and practical forensic laboratory needs. An educational outreach project involving three post-secondary academic institutions and a large multidisciplinary forensic laboratory was created to provide lectures to students, enable mentorship ... | Educational outreach and incubator concept proposal
Goals
The partnership between the NYSP CLS and the academic institutions aims to increase the quality and quantity of applicants for laboratory employment. Various methods have been explored to attempt to bridge the gap between the forensic laboratory and post-seconda... | Acknowledgements
The authors wish to gratefully acknowledge the support of the New York State Police, the College of St. Rose, Hudson Valley Community College, SUNY Albany, our Forensic Investigation Center mentor colleagues and the participating students who have made the inaugural year of this program a success. | CC BY | no | 2024-01-16 23:42:01 | Forensic Sci Int Synerg. 2023 Dec 17; 8:100448 | oa_package/6b/d5/PMC10788423.tar.gz |
PMC10788424 | 38226024 | Introduction
Over 700 different species of bacteria, fungi, viruses and protozoa have been discovered in the oral cavity [ 1 ]. These species interact with each other in various communities, collectively known as the oral microbiota. In a healthy environment, the oral microbiome is in balance with its host. However, dy... | Materials and methods
Strains and growth conditions
For this research, two different strains of P. gingivalis and C. albicans were used, a high virulent and a low virulent strain for each microorganism. P. gingivalis W83 is more virulent than ATCC 33277. W83 has a K1 type polysaccharide capsule and 33277 has no c... | Results
P. gingivalis survives in aerobic conditions in the presence of viable C. albicans
To evaluate the influence of C. albicans on the growth of P. gingivalis , co-cultures were grown and viability of P. gingivalis was determined by CFU counting. For both P. gingivalis strains W83 and ATCC 33277, the prese... | Discussion
The oral microbiome is a complex, diverse and dynamic biological system [ 1 ]. The microorganisms are constantly interacting with each other and with the host, which might influence the pathogenicity of certain species. The aim of this study was to characterize how the interaction between P. gingivalis and... | In the oral cavity Candida albicans interacts with many oral bacteria, including Porphyromonas gingivalis , both physically and metabolically. The aim of this in vitro study was to characterize these interactions and study their effects on the survival of P. gingivalis . First, metabolic interactions were evaluat... | Funding details
This project is funded by the faculty of Dentistry, Academic Centre for Dentistry in Amsterdam, University of Amsterdam and Free University of Amsterdam.
Disclosure statement
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be con... | Supplementary data
The following are the Supplementary data to this article:
Data availability
Data will be made available on request.
Acknowledgements
The authors thank prof P. van Dijck for kindly providing C. albicans mutants and Wendy Kaman for providing the protocol and materials for the gingipain activity assay... | CC BY | no | 2024-01-16 23:42:01 | Biofilm. 2023 Dec 17; 7:100172 | oa_package/29/7e/PMC10788424.tar.gz | |
PMC10788429 | 38226216 | Introduction
Loneliness: a public health problem
Loneliness is a serious public health problem. It leads to a higher risk of premature death and the onset and progression of a range of physical and mental health problems, such as cardiovascular diseases, infectious diseases, and depression [ [1] , [2] , [3] , [4] ].... | Methods
Ethical statement
This study was approved by the Medical Ethical Committee of the University of Maastricht (METC 2018–0698, 2019–1035, and 2020–2266). Participants gave electronic informed consent.
Study design and population
This cross-sectional study used data from the Dutch SaNAE cohort ( www.sanae-study.nl ... | Results
Study population
Of all participants, 55 % were men, and 43 % of the participants had a theoretical educational level. The mean age was 65 years ( Table 1 ).
Moderate/severe social and emotional loneliness
Of the men, 20 % (367/1874) were socially lonely and 25 % (476/1874) were emotionally lonely. Of the women... | Discussion
This detailed evaluation of loneliness in Dutch adults aged 40 years and older, uniquely evaluated the structure and function of social networks and did so in relation to social loneliness as well as emotional loneliness. Of men, 20 % and 25 % were (moderately/severely) socially and emotionally lonely, respe... | Conclusion
Our current study assessed structural and functional social network aspects associated with (moderately/severely) social and emotional loneliness for men and women separately and established that diverse and dense social networks and emotional and informational social support are key factors associated with ... | Background
Loneliness is a serious public health problem. This became even more visible during the COVID-19 pandemic. Yet, the key social network aspects contributing to loneliness remain unknown. Here, we evaluated social network structure and function and associations with (moderate/severe) social and emotional lonel... | Data availability statement
The dataset supporting the conclusions of this article is available upon request. Data contains potentially identifying and sensitive information of respondents. Due to the General Data Protection Regulation, it is not allowed to distribute or share any personal data that can be traced back ... | Supplementary data
The following is the Supplementary data to this article. | CC BY | no | 2024-01-16 23:42:01 | Heliyon. 2023 Dec 16; 10(1):e23734 | oa_package/2a/b8/PMC10788429.tar.gz |
PMC10788430 | 38226362 | Background
It is estimated that cerebrovascular disease (CVD) is a contributing factor in about 70 % of dementia cases, while it is the major or only etiological factor in 15–25 % cases [1] . Vascular contributions to cognitive impairment and dementia (VCID), which covers the spectrum of cognitive impairment attributa... | Method
Collaborations included were identified by literature search (Pubmed, published 2015–2023), direct approach to principal investigators/key contacts, and chain-referrals from these contributors. Initiatives were included if they met the criteria of 1) focused on VCID, 2) collaborative either national or internati... | Future recommendations and conclusion
This paper presents an overview of recent significant collaborative initiatives in VCID. Although our understanding and appreciation of VCID has grown immensely from these and other efforts, there is clearly a need for increased research effort in this field. One area we have ident... | Highlights
• This paper summarises 24 large-scale collaborations into vascular contributions to cognitive impairment and dementia (VCID). • Current research focuses on the mechanisms of action, means of prevention, and treatment of VCID. • There have been previous and are ongoing consensus efforts focused on harmonisin... | Collaborations to understand disease mechanisms and develop biomarkers for VCID
National collaborations
Biomarkers for Vascular Contributions to Cognitive Impairment and Dementia (MarkVCID)
MarkVCID is a USA-based consortium that identifies and validates biomarkers involved in the pathophysiology underlying cerebral sm... | Supplementary materials
Acknowledgments
The following individuals kindly provided information on the initiatives they lead or are a part of: Sarah Bauermeister, Adam Bentvelzen, Geert Jan Biessels, Amy Brodtmann, Rory Chen, Mat J Daemen, Charles DeCarli, Marco Duering, Israel Fernandez Cadenas, Myriam Fornage, John... | CC BY | no | 2024-01-16 23:42:01 | Cereb Circ Cogn Behav. 2023 Dec 14; 6:100195 | oa_package/fd/73/PMC10788430.tar.gz | ||
PMC10788433 | 38226267 | Introduction
770 million infections and 6.96 million deaths worldwide were caused by the SARS-CoV-2 pandemic between December 2019 and the end of September 2023 [ 1 ]. Comprehensive measures were established in most parts of the world to contain the contagions, with often far-reaching restrictions on social life, as we... | Material and methods
Study population
The information was obtained by administering a confidential online questionnaire to participants at the Mannheim Medical Faculty of the University of Heidelberg and the Wuerzburg Medical Faculty during the period of December 01, 2021, to March 31, 2022. Medical studies in Germany ... | Results
Sample description
Complete data from 668 students and physicians were included in the analysis. The sample primarily consisted of females (n = 484, 72.5%) with ages ranging from 18 to 42 years.
Table 1 presents a summary of sociodemographic data and COVID-19 specific inquiries for the whole study population a... | Discussion
The evolution of the HADS over the course of the pandemic shows different dynamics according to sex. It is known, that there was a pre-existing “sex gap” in depression and anxiety symptoms already prior to the outbreak of the pandemic, though this is surely not the only explanation for the sex differences as... | Shared first authorship.
Background
Healthcare workers and medical students faced new challenges during the COVID-19 pandemic. Processes within many hospitals were completely disrupted. In addition, the face to face teaching of medical students was drastically reduced. Those at risk of developing mental health problems... | Data availability statement
The raw data supporting the conclusions of this article will be made available by the authors on request.
CRediT authorship contribution statement
Marie Halfmann: Writing – original draft, Visualization, Investigation, Formal analysis, Data curation. Noah Castioni: Writing – original draf... | Supplementary data
The following are the Supplementary data to this article: | CC BY | no | 2024-01-16 23:42:01 | Heliyon. 2023 Dec 19; 10(1):e23727 | oa_package/fa/97/PMC10788433.tar.gz | |
PMC10788434 | 38226289 | Introduction
Corona Virus Disease (Covid-19) has spread throughout the world rapidly starting from the end of December 2019. It has infected millions of people around the world and can cause death. Therefore, this problem is designated as a global pandemic by World Health Organization [ [1] , [2] , [3] , [4] , [5] ... | Methods
This study used a descriptive qualitative research method to describe the object of research in the form of written or spoken words from people and observed behavior [ 32 ]. The focus of this study was the construction built by the community as a conscious effort to respond to disasters in the midst of a pandem... | Results and discussion
Community disaster response awareness in the midst of the implementation of LSSR to CARE could be analyzed through construction built on knowledge and reality about disaster response and the spread of Covid-19. Based on the formation of the construction, it allowed the public to raise awareness i... | Results and discussion
Community disaster response awareness in the midst of the implementation of LSSR to CARE could be analyzed through construction built on knowledge and reality about disaster response and the spread of Covid-19. Based on the formation of the construction, it allowed the public to raise awareness i... | Conclusion
As a conclusion, first, socially, the community has not taken the dangers of Covid-19 seriously, which is proven by violations of the rules when implementing LSSR and CARE. For instance, people have not implemented 5 M properly. Second, there is an inconsistency between knowledge and social reality related t... | This study aimed to analyze the community's disaster response awareness during the Covid-19 pandemic during the implementation of The Large-Scale Social Restrictions (LSSR) in Gresik. Self-awareness was observed using Peter L. Berger and Thomas Luck man's Social Construction Theory through a dialectical process of inte... | Society and health protocol
The implementation of health protocols in the community rose various problems. On the one hand, they must implement health protocols starting from wearing masks, washing hands with soap, maintaining distance, staying away from crowds, and limiting mobility and interaction. However, this situ... | CC BY | no | 2024-01-16 23:42:01 | Heliyon. 2023 Dec 20; 10(1):e23880 | oa_package/cd/78/PMC10788434.tar.gz | |
PMC10788437 | 38142637 | Introduction
Refractory respiratory failure is the leading cause of death in patients critically ill with COVID-19 1 and immune-mediated acute lung injury rather than direct cytotoxic effects of SARS-CoV-2 infection appears central to disease severity. 2 Characterisation of the host immune response at the lung tissu... | Methods
Tissue bank assembly and cohort description
Lung tissue was obtained via autopsy by the Letulle method from three United Kingdom Tissue Biobanks from individuals with clinical and microbiological evidence that COVID-19 disease was the primary precipitant of death with a period of recruitment from of 1 year from... | Results
Demographics and clinical features
Lung tissue was analysed from 40 individuals who died with severe COVID-19 (8F/32M). Median age at death was 72 years (IQR = 61.5–79.75 years), with 28/40 (70%) dying in hospital and 12/40 (30%) dying in the community. Median duration of illness was 12 days (IQR = 8.75–22.25 d... | Discussion
In this study, we present a comprehensive assessment of the immune cell signature and structural cell composition in lung tissue from fatal COVID-19. Our data places particular emphasis on spatial and temporal differences in the heterogeneous patterns of tissue injury. We show that the pathological evolution... | Denotes equal contribution by authors.
Summary
Background
Lung damage in severe COVID-19 is highly heterogeneous however studies with dedicated spatial distinction of discrete temporal phases of diffuse alveolar damage (DAD) and alternate lung injury patterns are lacking. Existing studies have also not accounted for pr... |
Contributors
Luke Milross MD : conceptualization, formal analysis, investigation, data curation, writing—original draft, visualisation; Bethany Hunter : methodology, validation, formal analysis, investigation, data curation, writing—original draft, visualisation; David McDonald PhD : formal ani.ealysis, investiga... | Supplementary data
Acknowledgements
This work was partly funded by UKRI/ 10.13039/501100000265 Medical Research Council through the 10.13039/501100023449 UK Coronavirus Immunology Consortium (UK-CIC) as well as the Barbour Foundation. The authors would like to acknowledge the tissue donors and their families f... | CC BY | no | 2024-01-16 23:42:01 | eBioMedicine. 2023 Dec 23; 99:104945 | oa_package/40/38/PMC10788437.tar.gz | |
PMC10788446 | 38226281 | Introduction
Metal-orgnaic frameworks (MOFs) are constructed by combining metal ions and organic linkers to form porous extended networks of different topologies [ 1 , 2 ]. The wide range of metal nodes and organic linkers, as well as the possibility of post-modifications, have resulted in the development of hundreds o... | Methodology
Materials
Zirconium chloride (ZrCl 4 , 98 %) and acetic acid (C 2 H 4 O 2 , 99 %) were purchased from Acros Organics. 2-Aminoterephthalic acid (C 8 H 7 NO 4 , 99 %) was purchased from Sigma Aldrich. The organic solvents at highly pure grade (99 %) were purchased from Fisher Scientific.
General synthesis pro... | Results and discussion
Structural characterization of UiO-66(NH 2 ) catalyst
The PXRD pattern of the synthesized UiO-66(NH 2 ) nanocrystals was recorded and compared to the simulated pattern ( Fig. 1 ). It showed narrow and sharp peaks that are in good agreement with the calculated one, which demonstrates the high crys... | Results and discussion
Structural characterization of UiO-66(NH 2 ) catalyst
The PXRD pattern of the synthesized UiO-66(NH 2 ) nanocrystals was recorded and compared to the simulated pattern ( Fig. 1 ). It showed narrow and sharp peaks that are in good agreement with the calculated one, which demonstrates the high crys... | Conclusions
The specific free energy, enthalpy and entropy of adsorption of polar organic solvents adsorbed on UiO-66(NH 2 ) surface were evaluated by using ten different IGC methods and models included Hamieh model that took into account the thermal effect. The seven molecular models were used to determine the dispers... | Amino-functionalized metal organic frameworks (MOFs) have attracted much attention for various applications such as carbon dioxide capture, water remediation and catalysis. The focus of this study is to determine the surface and Lewis's acid-base properties of UiO-66(NH 2 ) crystals by the inverse gas chromatography (I... | Ethical approval
This article does not contain any studies with human participants performed by any of the authors.
Data availability statement
Data are included in the article and in supplementary material.
CRediT authorship contribution statement
Ali Ali-Ahmad: Writing – review & editing, Writing – original draft, V... | Supplementary data
The following is the Supplementary data to this article: | CC BY | no | 2024-01-16 23:42:01 | Heliyon. 2023 Dec 17; 10(1):e23839 | oa_package/08/d9/PMC10788446.tar.gz |
PMC10788447 | 38226274 | Introduction
In an ever-evolving market driven by technological advancements and increasing consumer purchasing power, the pursuit of novel products and services remains constant. However, the path to success in New Product Development (NPD) projects is often fraught with challenges, leading to failure either during th... | Materials and methods
Research design
In addition to conducting literature research, this study incorporates a one-to-one interview with the CEO of a Malaysia-based company who plays a pivotal role in the success of the firm's product and service development. The one-to-one interview method is widely utilized for data ... | Results
Applying the thematic analysis initially resulted in the identification of 13 potential themes. However, after thoroughly examining the interview content and correlating the context with the proposed themes, the number was refined down to five key themes as below. For better illustration, please see Fig. 1 .
I... | Conclusions
The complexities of NPD are multifaceted and cannot be underscored enough. Through our investigation, it has become evident that a successful NPD strategy isn't solely contingent on a firm's internal strategies, processes, or cross-functional collaborations. Instead, it is intricately interwoven with a mult... | New product development (NPD) frequently encounters failures, whether during the development phase or in the subsequent commercialization stage. These failures can often be attributed to root causes originating in the early stages of NPD, known as the front end. This study aims to investigate the factors that contribut... | Success factors for NPD
Top management commitment
Top managers or decision-makers are the ones who give a green or red light when a proposal is presented. This is the very first stage of product development that involves getting approval from the top management. If top management is closely involved in the early stages... | Acknowledgment
The authors express their deep appreciation to Mr. Leo Wein, Director of Protenga Sdn. Bhd. (Company Registration Number: 201801004055, 1266069-U), for his valuable support in this project. | CC BY | no | 2024-01-16 23:42:01 | Heliyon. 2023 Dec 17; 10(1):e23763 | oa_package/88/f9/PMC10788447.tar.gz | |
PMC10788449 | 38226249 | introduction
The study of the effects of tip leakage flow in turbo-machines has undoubtfully been one of the major topics that have concerned the minds of great scientists of the aforementioned field.
In turbo-machines, tip leakage flow, caused by the pressure difference of suction and pressure surface of the blade, is... | Methodology
Using Artificial Neural Network (ANN) as a powerful tool is a common method to use for optimization problems. The most important advantage of this optimization coupling is the reduction of the computational costs in the optimization algorithm cycle. The coupling of ANNs with the genetic algorithm has been w... | result and discussion
In the optimization process, a database of 27 arrays was used and then GA coupled with ANNs was solved. In this process, two categories of squealer tips were studied. The first category is suction-side squealer, and the second one is double-sided squealer. The results for the squealer-tip blades c... | result and discussion
In the optimization process, a database of 27 arrays was used and then GA coupled with ANNs was solved. In this process, two categories of squealer tips were studied. The first category is suction-side squealer, and the second one is double-sided squealer. The results for the squealer-tip blades c... | conclusion
The study explores the use of squealer tip to improve the performance of axial compressor blades in various operating conditions in a specified tip clearance similar to baseline geometry. Splines with control points are utilized to modify the geometry of the squealer tip, both on the suction and pressure sur... | This research represents an innovative method for geometry generation of the squealer-tip in axial compressor rotors and its exploit in a numerical optimization process to obtain a better stage performance. For this purpose, the NASA Rotor-67 transonic compressor rotor blade is used as a test case to study the aerodyna... | Nomenclature
Coefficients of squealer depth spline for pressure side
Coefficients of squealer depth spline for suction side
Coefficients of squealer height
The minimum, maximum and middle of Coefficient
Artificial neural network
Correction factor
Coefficient of squealer-tip
Pressure coefficient
Design of experiments
Th... | Acknowledgments
Not applicable. | CC BY | no | 2024-01-16 23:42:01 | Heliyon. 2023 Dec 21; 10(1):e23665 | oa_package/d7/bc/PMC10788449.tar.gz |
PMC10788466 | 38071459 | INTRODUCTION
In the plant immune system, the first line of defence against pathogenic microorganisms, pattern‐triggered immunity (PTI) is mediated by membrane‐localized pattern recognition receptors (PRRs) that recognize microbial‐ or pathogen‐associated molecular patterns (MAMPs or PAMPs). Subsequently, effector‐trigg... | RESULTS
MdVQ12 positively regulates apple resistance to V. mali
The analysis of MdVQ12's conserved domain identified a VQ domain (Figure S1a ). Protein feature visualization showed that this protein is located inside the cytomembrane, indicating that it is an intracellular localization protein (Figure S1b ). Su... | DISCUSSION
Apple Valsa canker, attributed to V. mali , inflicts significant economic losses. The poor efficiency and effectiveness of traditional control methods have limited apple production. Identifying disease resistance genes remains the most cost‐effective disease control approach. VQ proteins regulate many aspec... | Abstract
Valine‐glutamine (VQ) motif‐containing proteins play a crucial role in plant biotic stress responses. Apple Valsa canker, caused by the ascomycete Valsa mali , stands as one of the most severe diseases affecting apple trees. Nonetheless, the underlying resistance mechanism of VQ proteins against this disease ... | EXPERIMENTAL PROCEDURES
Plant and microbe materials
The apple tissue culture seedlings are of the GL‐3 genotype (Dai et al., 2013 ). The GL‐3 plantlets and apple cv. Orin calli were cultured on Murashige and Skoog (MS) medium at 25°C.
N. benthamiana seedlings were grown in a growth chamber and the V. mali WT stra... | ACKNOWLEDGEMENTS
We thank Dr Qiong Zhang of Northwest A&F University for her technical support. We also thank Zhiyuan Yin and Xiang Meng of Northwest A&F University for their help with the experiment. This work was supported by the National Natural Science Foundation of China (31871917) and the National Natural Science... | CC BY | no | 2024-01-16 23:42:01 | Mol Plant Pathol. 2023 Dec 10; 25(1):e13411 | oa_package/3f/3e/PMC10788466.tar.gz | ||
PMC10788467 | 38010059 | INTRODUCTION
Small cell lung cancer (SCLC) is an aggressive form of lung cancer characterized by high malignancy and an extremely dismal prognosis. 1 Extensive‐stage SCLC (ES‐SCLC) accounts for 70% of all SCLCs, defined as tumors with distant metastasis or exceeding the area that can be treated within a radiation ... | METHODS
Patients
We reviewed the electronic medical records of all patients diagnosed with ES‐SCLC who started anti‐PD‐1/PD‐L1‐based therapies from July 2019 to December 2020 at Shandong Cancer Hospital and Institute, China. Figure 1 summarizes the patient selection process. Finally, 214 patients were evaluable for r... | RESULTS
Patient characteristics
A total of 214 patients were included in this study. We first dichotomized the patients according to ATB exposure: 41 (19.2%) received ATB within 2 months before or after the first initiation of ICI therapy (ATB group), and the remaining 173 patients did not receive ATB (non‐ATB group). ... | DISCUSSION
To our knowledge, this is the first study to demonstrate the potential harmful effects of ATB exposure in Chinese ES‐SCLC patients receiving anti‐PD1/PD‐L1‐based immunotherapy. Our results confirm that ATB exposure within 2 months before or after the first infusion of ICIs is significantly associated with wo... | Abstract
Background
Immune checkpoint inhibitors (ICIs) have dramatically shifted the therapeutic paradigm of extensive‐stage small cell lung cancer (ES‐SCLC). Antibiotic (ATB) exposure before or during ICI therapy can harm the integrity of the gut microbiome and lead to intestinal dysbiosis, which has a profoundly neg... | AUTHOR CONTRIBUTIONS
Jiaqi Zhong: conceptualization, data curation, methodology, software, formal analysis, writing ‐ original draft; Dali Xiong: data curation, writing ‐ original draft; Yu Liu: supervision; Shuanghu Yuan: Writing ‐ review and editing.
FUNDING INFORMATION
This study was supported in part by the Nationa... | ACKNOWLEDGMENTS
We would like to thank all the reviewers who participated in the review. Finally, we wish to thank American Journal Experts ( china.aje.com ) for their inguistic assistance during the preparation of this manuscript.
DATA AVAILABILITY STATEMENT
The datasets used and/or analyzed during the current study a... | CC BY | no | 2024-01-16 23:42:01 | Thorac Cancer. 2023 Nov 27; 15(2):152-162 | oa_package/c6/95/PMC10788467.tar.gz | |
PMC10788471 | 38057283 | INTRODUCTION
Surgical resection remains the primary treatment for non‐small cell lung cancer (NSCLC), but some patients still experience distant metastasis and recurrence postoperatively. This poor outcome may be attributed to the presence of residual micrometastases or subclinical lesions. 1 , 2 In many pati... | METHODS
Patients and samples
We retrospectively enrolled 106 patients with NSCLC pathologically diagnosed at Shandong Cancer Hospital between January 2020 and August 2022. Inclusion criteria were patients with predominantly resectable stage IB (≥4 cm) to IIIB with no prior antitumor therapy. All patients underwent radi... | RESULTS
Patient characteristics
This study included 106 patients with NSCLC undergoing neoadjuvant immunochemotherapy followed by radical surgery, of whom 94 (88.7%) were male. The median age at diagnosis was 63 years (range 44–102 years). A total of 78 (73.6%) patients had squamous cell carcinoma and 28 (26.4%) had ad... | DISCUSSION
In this study, we investigated the relationship between pretreatment inflammatory biomarkers and postoperative tumor TLS status in 106 patients with NSCLC undergoing neoadjuvant immunochemotherapy. The results showed that the SII was negatively correlated with TLS abundance and maturity, and multivariate ana... | Abstract
Background
Neoadjuvant immunochemotherapy can effectively downstage tumors and reduce the risk of postoperative recurrence and distant metastasis in patients with non‐small cell lung cancer (NSCLC). In this study, we investigated the correlation between inflammatory biomarkers and tertiary lymphoid structure (... | AUTHOR CONTRIBUTIONS
Study design: Shuanghu Yuan, Fuhao Xu; Data acquisition and analysis: He Zhu, Dali Xiong, Fuhao Xu; Interpretation of the data: Fuhao Xu, Kang Wang, Yinjun Dong, Li Li; Drafting of the manuscript: Fuhao Xu; Revision of the manuscript: Shuanghu Yuan. All authors contributed to the article and approv... | ACKNOWLEDGMENTS
We thank all the participants who contributed to the article. We would like to thank Editage ( www.editage.cn ) for English language editing.
DATA AVAILABILITY STATEMENT
The datasets generated during and/or analyzed during the current study are available from the corresponding author on reasonable reque... | CC BY | no | 2024-01-16 23:42:02 | Thorac Cancer. 2023 Dec 6; 15(2):172-181 | oa_package/d0/4d/PMC10788471.tar.gz | |
PMC10788472 | 38018652 | INTRODUCTION
Despite significant improvements in the realm of anticancer strategies, whatever chemotherapy is administered as a monotherapy or in combination with other treatment paradigms encompassing surgery, radiotherapy, immune checkpoint inhibitors (ICIs), antiangiogenesis agents, targeted therapies, and beyond, i... | METHODS
This prospective, randomized, placebo‐controlled, multicenter clinical study was conducted at three major cancer centers in Sichuan province, China: Thoracic Oncology Ward, West China Hospital, Sichuan University; Cancer Center, No.7 People's Hospital of Chengdu; Cancer Center, People's Hospital of Sichuan Prov... | RESULTS
Patient characteristics
From March 2021 to January 2022, 110 patients were enrolled, of whom one patient withdrew their informed consent and 18 patients were excluded due to protocol violation. A total of 91 patients were included in the final statistics. No significant differences were observed between the two... | DISCUSSION
Our study demonstrated that compound probiotic supplements can improve the quality of life and relieve platinum‐based doublet chemotherapy‐induced gastrointestinal adverse reactions for lung cancer patients undergoing chemotherapy. Previous clinical studies have also indicated that probiotics may ameliorate ... | Abstract
Background
Chemotherapy is an important approach for lung cancer patients. The study was designed to evaluate the feasibility of the compound probiotic supplements in improving the quality of life for lung cancer patients undergoing chemotherapy.
Methods
This randomized, double‐blind, placebo‐controlled trial ... | AUTHOR CONTRIBUTIONS
All authors had full access to the data in the study and take responsibility for the integrity of the data and the accuracy of the data analysis. Conceptualization , Yu Sun and Jiang Zhu; Data curation , Jialong Han, Ping Chen, and Ke Xie; Formal analysis , Hao Wei, Zhiying Yue, and Jialong Han;... | ACKNOWLEDGMENTS
We would like to thank all those who participated in this study. The Cancer Psychology and Health Management Committee of the Sichuan Cancer Society supported this trial. | CC BY | no | 2024-01-16 23:42:02 | Thorac Cancer. 2023 Nov 29; 15(2):182-191 | oa_package/96/a0/PMC10788472.tar.gz | |
PMC10788474 | 38013668 | INTRODUCTION
Advanced non‐small cell lung cancer (NSCLC) is an aggressive and difficult to eradicate disease. Recently, outcomes have improved significantly owing to the use of immune checkpoint inhibitors (ICIs), such as antiprogrammed death‐1 (PD‐1) and antiprogrammed death ligand‐1 (PD‐L1) antibodies. 1 Chemoim... | METHODS
Patients and study design
The REACTIVE study design has been reported previously. 6 The REACTIVE study was a multicenter retrospective investigation involving 62 Japanese institutions.
It included 288 patients (222 men and 66 women; median age, 67 years; age range, 20–82 years) with advanced NSCLC who rece... | RESULTS
Patient demographics and front‐line therapy
Patient information including maintenance therapy, duration of ICI treatment, and ORR of front‐line chemoimmunotherapy are shown in Table 1 . As described in our previous report, 6 KEYNOTE 189, 2 KEYNOTE 407, 3 IMpower 150, 4 IMpower 130, 17 ... | DISCUSSION
Our exploratory analysis identified the transition to maintenance therapy and ICI treatment for >180 days in front‐line chemoimmunotherapy as independent predictors of better outcomes after RD administration in patients with advanced NSCLC. Although all patients receiving ICIs for >180 days also received mai... | Abstract
Background
The factors that predict the clinical response to ramucirumab plus docetaxel (RD) after first‐line chemoimmunotherapy are unresolved. We explored whether the therapeutic efficacy of prior chemoimmunotherapy could predict the outcome of RD as sequential therapy in patients with advanced non‐small cel... | AUTHOR CONTRIBUTIONS
Ou Yamaguchi: Conceptualization; Data curation; Formal analysis; Funding acquisition; Investigation; Methodology; Project administration; Writing original draft; Draft review and editing. Keita Mori: Conceptualization; Formal analysis; Methodology; Writing original draft; Writing original draft; Dr... | ACKNOWLEDGMENTS
The authors thank Yuka Matsui (M‐Techno Planning), Tomohiro Marui 14 (M‐Techno Planning), and Hisao Imai (M.D., PhD, Saitama Medial University International 15 Medical Center) for their assistance with the manuscript. The authors also thank Editage 16 ( www.editage.jp ) for English language editing.
DAT... | CC BY | no | 2024-01-16 23:42:02 | Thorac Cancer. 2023 Nov 27; 15(2):163-171 | oa_package/96/fe/PMC10788474.tar.gz | |
PMC10788475 | 38011005 | INTRODUCTION
Thymic epithelial tumors (TETs) are rare tumors that occur in the anterior mediastinum, accounting for less than 1% of adult malignancies. 1 , 2 , 3 TETs include thymoma and thymic carcinoma and can be further classified into A, AB, B1, B2, B3, and C (i.e., thymic carcinoma) subtypes based o... | METHODS
Study design and data collection
A total of 1242 patients with pathologically documented TETs at Zhejiang Cancer Hospital from October 2016 to October 2022 were screened, among which 52 patients treated with small molecule multitarget antiangiogenic inhibitors were enrolled. The major inclusion criteria were: E... | RESULTS
Characteristics of patients
A total of 52 patients with TETs who had been treated with small molecule multitarget antiangiogenic inhibitors were enrolled in this retrospective study (Figure 1 ). The baseline characteristics of all the patients are shown in Table 1 . These patients had a median age of 55 (rang... | DISCUSSION
As TET is a relatively rare and indolent tumor, the patients can survive a considerable length of time after disease progression or relapse, making it extremely difficult to conduct large‐scale prospective randomized studies. 19 To the best of our knowledge, this real‐world retrospective study of small ... | Abstract
Background
Thymic epithelial tumors (TETs) are rare malignant tumors with limited treatment options. No established second‐line treatment regimen is available following the preferred first‐line chemotherapy, resulting in unsatisfactory efficacy and poor prognosis for patients with advanced TETs. This study aim... | AUTHOR CONTRIBUTIONS
Y.F. conceived the idea and designed the framework of the manuscript. W.S. conducted data analysis and interpretation, performed literature searches, and wrote the manuscript. Y.J. revised the entire manuscript and ensured its integrity. Y.Y. and N.C. contributed to data acquisition. All authors ha... | CC BY | no | 2024-01-16 23:42:02 | Thorac Cancer. 2023 Nov 27; 15(2):122-130 | oa_package/9c/f1/PMC10788475.tar.gz | ||
PMC10788477 | 38226083 | Introduction
This article was previously presented as an e-poster at the 15th IHPBA World Congress in New York City in March 2022 and was published online as an abstract in October 2022 in the HPB journal.
Periampullary cancer includes neoplasms arising from four different anatomical sites with proximity to the major d... | Materials and methods
We retrospectively analyzed records of patients who underwent pancreaticoduodenectomy (PD) at Tribhuvan University Teaching Hospital, Kathmandu, Nepal, from April 2004 to May 2014. The data was updated until April 2021. The staging of the disease was done according to the 8th edition of the Americ... | Results
There were 115 patients who underwent PD from April 2004 to May 2014. Among them, 54 patients were excluded from the study for various reasons, as shown in Figure 1 . Thus, the study included 61 patients.
The median duration of follow-up was 12 months (3 to 180 months). Demography and clinic-pathological feat... | Discussion
Pancreaticoduodenectomy is the standard treatment for periampullary cancers. Postoperative complications and mortality have decreased with the advent of better surgical techniques and perioperative care. However, the long-term survival outcome is still low, and the five-year survival rate reported varied wid... | Conclusions
The presence of perineural invasion is associated with poor survival outcomes in periampullary cancer patients following pancreaticoduodenectomy. Also, pancreatic cancer has poor survival as compared to other periampullary cancers. | Background
Periampullary cancers arise from four different anatomical sites and are in close proximity. But they have different survival outcomes. There are various clinicopathological factors associated with survival after pancreaticoduodenectomy done for periampullary cancers. So, we aimed to identify the predictive ... | CC BY | no | 2024-01-16 23:42:02 | Cureus.; 15(12):e50607 | oa_package/96/59/PMC10788477.tar.gz | ||
PMC10788479 | 38041547 | INTRODUCTION
Lung cancer is the primary cause of cancer‐related deaths worldwide. In general, non‐small cell lung cancer (NSCLC) make up approximately 85% of lung cancers, while small cell lung cancer (SCLC) comprises 15% of lung cancer cases. 1 From a histological point of view, lung adenocarcinoma (LUAD) and lun... | METHODS
Patients and clinical data collection
The enrollment for this study of patients who were diagnosed with NSCLC took place at West China Hospital of Sichuan University in China from 2020 to 2021. All patients included in the study underwent surgical treatment without receiving neoadjuvant therapy before surgery. ... | RESULTS
The overall profiles of lung microbiome
To characterize and visualize human NSCLC microbiota based on lung tissues, we performed metagenomic sequencing on 61 tumor tissues (tumor, n = 61) and their paired normal tissues (normal, n = 61), comprising 43 LUAD and 18 LUSC (Figure 1a , Tables S1 and S2). Beyo... | DISCUSSION
In this study, we integrated metagenomic sequencing to characterize the microbiome based on NSCLC tissues and provide a comprehensive method by which nearly all microbiota can be accurately identified, without the need for sequence‐specific amplification. 40 Previous studies on the microbiota in the air... | Abstract
Background
The lung has a sophisticated microbiome, and respiratory illnesses are greatly influenced by the lung microbiota. Despite the fact that numerous studies have shown that lung cancer patients have a dysbiosis as compared to healthy people, more research is needed to explore the association between the... | AUTHOR CONTRIBUTIONS
Z. Wang, G. Rao, L. Yuan, and J. Gao performed metagenomic sequencing and processed the data. L. Yuan, J. Gao Y, and C. Cheng performed bioinformatic analyses. J. Tang obtained patient consent and collected the samples. Y. Li assisted in participant selection, consent, clinical information, and pro... | ACKNOWLEDGMENTS
We are grateful to all the patients for their voluntary participation in the study. This study was supported by the National Natural Science Foundation of China (92159302 and 32170592), and the Sichuan Science and Technology Program (2023NSFSC0041, 2022NSFSC0785, 2020YFS0572, and 2020YFS0573). | CC BY | no | 2024-01-16 23:42:02 | Thorac Cancer. 2023 Dec 2; 15(2):111-121 | oa_package/18/a5/PMC10788479.tar.gz | |
PMC10788481 | 37516011 | Introduction
Functional neurological disorder (FND) is a condition involving the experience of neurological (seizures, sensory and/or motor) symptoms which are clinically distinguishable from those caused by identifiable neuropathology ( APA, 2013 ; Drane et al., 2021 ). The mechanisms and aetiology underlying FND rem... | Methods
Participants
Seventeen patients with FMS/FS and 17 healthy controls were included. The sample size was deemed appropriate given the goals of the broader pilot project in which this study was conducted. Patients with FMS/FS were recruited online via mailing lists, social media, and advertisements circulated by c... | Results
Participant characteristics
The characteristics of the sample are detailed in Table 1 . The groups were comparable in age, gender, BMI, and intellectual functioning. The FMS/FS group reported additional functional symptoms including dizziness, cognitive difficulties, sensory, and speech/swallowing difficulties... | Discussion
This study aimed to elucidate the possible role of interoceptive processing in FMS/FS, testing the hypotheses that interoceptive accuracy and insight would be reduced, and interoceptive sensibility would be significantly altered in FMS/FS compared to HCs. A further aim was to explore how interoception may be... | Conclusions
Individuals with FMS/FS may not exhibit consistently reduced interoceptive accuracy, but may experience reduced interoceptive insight alongside altered interoceptive sensibility (“Not-Distracting”, Trusting”). These results provide further evidence that there may be a separation between trait and state inte... | Altered interoception may be a pathophysiological mechanism in functional neurological disorder (FND). However, findings have been inconsistent across interoceptive dimensions in FND including functional motor symptoms (FMS) and seizures (FS). Here, individuals with FMS/FS (n = 17) and healthy controls (HC, n = 17) com... | Source of funding
The study was supported by a Medical Research Council Career Development Award to SP [MR/V032771/1]. This paper also represents independent research part-funded by the National Institute for Health and Care Research (NIHR) Biomedical Research Centre at South London and Maudsley NHS Foundation Tru... | Supplementary data
The following is the Supplementary data to this article:
Data availability
Data will be made available on request.
Acknowledgements
Thank you to our FND Patient and Carer Advisory Panel, all participants, FND Hope UK and FND Action for supporting the project. Thanks also to Emily Ward and Yiqing Sun ... | CC BY | no | 2024-01-16 23:42:02 | Behav Res Ther. 2023 Sep; 168:104379 | oa_package/44/5d/PMC10788481.tar.gz |
PMC10788482 | 38101148 | Introduction
Over three years since the first COVID-19 vaccine was approved, many countries still have sub-optimal vaccination rates despite holding large amounts of vaccines. Some are even destroying expired vaccine stocks because of low demand [1] . They have sought to increase vaccine uptake using a range of measur... | Methods
Data
We use data on daily vaccines administered per municipality for the 80 municipalities of North Macedonia during the period from 1st March to 17th April. We include any vaccination administered in the municipality, either at the caravan or in any healthcare facility, given our need to capture any lagged eff... | Results
Descriptive statistics
Since the intervention was not randomly implemented, there are some differences between treated and control municipalities (Table A3 in Appendix A). Treated municipalities have a larger and younger population and a higher share of the population are foreign-born. In contrast, they have si... | Discussion
We describe the effectiveness of the North Macedonia COVID-19 caravan, a community-based intervention that involved sending mobile vaccination units to different locations to increase vaccination rates. Results from our difference-in-difference analysis show that the mobile vaccination caravan had a persisti... | Conclusions
Taken together, our results show that mobile vaccination units can be an effective tool to increase COVID-19 vaccination rates, even in the context of persistent suboptimal vaccine uptake. It demonstrates cost-effectiveness in comparison to alternative approaches, such as lotteries. This may provide useful ... | Highlights
• We examine the effectiveness of a COVID-19 vaccination caravan in North Macedonia. • The caravan increased vaccinations by 35 % during 3 weeks after the visit. • We estimate a cost-effectiveness of 25.4 US dollars per additional vaccination induced. • Mobile vaccination caravans can be cost-effective inter... | COVID-19 vaccination in North Macedonia and the caravan
North Macedonia is one of the countries with the lowest COVID-19 vaccination rates in Europe. By the beginning of the intervention, in March 2022, around 45 % of the population was fully vaccinated (i.e.: had received two doses of the vaccine). This is similar to ... | Supplementary materials
Acknowledgements & Funding
We are very grateful to Sara Kajevikj, Goran Kochinsksi, Thanas Goga, Ben Duncan and Brett Craig from WHO Europe and the North Macedonia Country Office who provided the data, comments and support during the research project. We thank members of the Competence Centr... | CC BY | no | 2024-01-16 23:42:02 | Health Policy. 2024 Jan; 139:104966 | oa_package/45/c0/PMC10788482.tar.gz |
PMC10788493 | 38226180 | Introduction
The SARS-CoV-2 virus responsible for the COVID-19 pandemic first appeared in December 2019 in Wuhan, China [ 1 ]. It caught the world's attention in total surprise, unlike any past epidemic/pandemic, e.g., the Great Influenza pandemic during World War I [ 2 ]. Beginning in 2020, news of the outbreak of COV... | Methods
Settings
Bangladesh Health Watch (( https://bangladeshhealthwatch.org ) is a civil society initiative for advocacy and monitoring to improve Bangladesh's health system by critically reviewing policies and programmes and facilitating appropriate actions for change. BHW has taken the initiative to archive all pee... | Results
A total of 11 articles on COVID-19 ‘governance’ were selected for review ( Table 3 ). Of these, two were cross-sectional surveys; two were qualitative studies; two were reviews; two were perspective pieces, and one each of case study, report and a mixed-method study. The review findings are described below unde... | Discussion
This study presents critical reflections on Bangladesh Government's COVID-19 governance response through a review of selected papers on the topic (n = 11), followed by expert deliberations on the review findings. Findings reveal a lack of governance capability to mount a quick, effective and efficient respon... | Conclusions
Bangladesh's COVID-19 response in the early months was characterised by slow, delayed and ambiguous measures which reflected poorly on its governance [ 48 ]. Governance gaps in areas such as instituting screening and lockdown measures, prioritising safety and security of the frontline workers to preserve th... | Background
On January 30, 2020, WHO declared COVID-19 as a Global Public Health Emergency. The first three COVID-19 cases in Bangladesh were confirmed on March 8, 2020. Thus, Bangladesh got substantial time to prepare the people and the health systems to respond to the outbreak However, neither the health ministry nor ... | Ethics approval and consent to participate
Not applicable.
Patient consent for publication
Not applicable.
Availability of data and materials
All data generated and analysed during this study are included in this published aeticle.
Funding
This research did not receive any specific grant from funding agencies in the pu... | Supplementary data
The following is the Supplementary data to this article:
Acknowledgements
The researchers appreciate the support they received from Bangladesh Health Watch Secretariat while conducting the research. | CC BY | no | 2024-01-16 23:42:02 | Public Health Pract (Oxf). 2023 Dec 16; 7:100457 | oa_package/6a/2b/PMC10788493.tar.gz |
PMC10788500 | 38226206 | Introduction
Hunger breeds discontentment, safety is the supremacy for food, according to an old Chinese saying. Food safety is related to people's health and the future of the Chinese nation (Xi, 2014). The report of the 20th National Congress of the Communist Party of China emphasizes the necessity to strengthen food... | Methods
Design
This paper utilizes the Ordered Probit model to investigate the impact of food safety perception on farmers’ happiness, using the data collected from the China Social Survey (CSS). To address sample selection bias, the paper employ propensity score matching (PSM) method, the recursive bivariate ordered p... | Results and discussion
Benchmark regression
In Table 3 , columns (1)–(3) list the OLS model estimates, whereas columns (4)–(6) list the Oprobit model estimates. Overall, the model runs well, with the F value and the Wald test values both passing the significance test at the statistical level of 1 %. Additionally, ther... | Results and discussion
Benchmark regression
In Table 3 , columns (1)–(3) list the OLS model estimates, whereas columns (4)–(6) list the Oprobit model estimates. Overall, the model runs well, with the F value and the Wald test values both passing the significance test at the statistical level of 1 %. Additionally, ther... | Conclusions and insights
This paper systematically examines the impact of food safety perception on farmers' happiness, using the data collected from the China Social Survey in 2013. The empirical results show that farmers' perception of food safety is significantly positively related to their level of happiness, and t... | Zhongkun Zhu and Chenxin Leng are co-first authors of this paper.
Although the determinants of individuals' happiness have been widely examined in the literature, little is known regarding whether and how food safety perception affects farmers' happiness. To fill this research gap, this paper examines the impact of foo... | Literature review
Theory as the ground of this study
Happiness is the ultimate goal of human beings, which is an overall evaluation of personal quality of life and subjective feedback on their inner state [ 5 , 6 ]. Happiness is also a permanent topic among scholars. More than 2000 years ago, Aristotle proposed that ha... | CC BY | no | 2024-01-16 23:42:02 | Heliyon. 2023 Dec 19; 10(1):e23868 | oa_package/18/e8/PMC10788500.tar.gz | |
PMC10788501 | 38226243 | Introduction
Cyclosporine A (CsA) is the immunosuppressor most frequently used in transplant surgery and in the treatment of autoimmune diseases because of its specific inhibiting effect on the signal transduction pathways of cell T receptor. CsA-induced kidney and liver damage is the main clinical problem associated w... | Materials and methods
Materials
Star anise ( Illicium verum ) was procured from a specialized aromatic plant market in Cairo – Egypt. Vitamins (A, E, D, B complex, Folic acid and C) and element (Zn) were procured from local pharmacy in Cairo – Egypt. Soy lecithin granules were obtained from Solgar, Inc. (Leonia, NJ 076... | Results and discussion
The total phenolic content and antioxidant activity of star anise oil
Results shown that the amount of total phenolic content was 265.01 ± 1.50 μg GAE gallic acid equivalent/ml. Anise oil showed good reducing power (0.188 ± 0.01 mg Vit C equivalent/ml). The reducing power of essential oil might b... | Results and discussion
The total phenolic content and antioxidant activity of star anise oil
Results shown that the amount of total phenolic content was 265.01 ± 1.50 μg GAE gallic acid equivalent/ml. Anise oil showed good reducing power (0.188 ± 0.01 mg Vit C equivalent/ml). The reducing power of essential oil might b... | Conclusion
The results revealed no statistically significant differences between samples containing vitamins-loaded flavoured nanophytosomes and control ones. It can be concluded that vitamins-loaded flavoured nanophytosomes may be offered as an efficient natural food preservative. Flavoured nanophytosomes containing v... | This study investigated the effect of flavoured nanophytosomes loaded with vitamins A, E, D, B complex, folic acid, and C, as well as zinc on the immunosuppressive cyclosporin A (CsA)-induced liver and kidney injury in male rats. The vitamins flavoured nanophytosomes (VFnPs) were characterized in terms of particle size... | Data availability statement
The data that support the findings of this study are available within the article.
CRediT authorship contribution statement
Manal M. Ramadan: , Supervision, Project administration, Investigation, Conceptualization. Rasha S. Mohamed: , Visualization, Validation, Methodology, Investigation,... | Acknowledgement
Authors would like to thank the 10.13039/100007787 National Research Centre , Egypt for ongoing co-operation to support research and that provided facilities necessary to achieve the desired goals of research. This study founded in partial fulfilment of the requirement of internal project submitted for... | CC BY | no | 2024-01-16 23:43:42 | Heliyon. 2023 Dec 19; 10(1):e23894 | oa_package/b0/ed/PMC10788501.tar.gz |
PMC10788502 | 38226241 | Introduction
Spirocyclic compounds are an attractive target in drug discovery due to their enriched bio-profile [ [1] , [2] , [3] ]. These molecules are widely distributed in natural and non-natural products and show impressive biological properties [ [4] , [5] , [6] ]. Other applications of spirocyclic molecules i... | Materials and methods
All chemicals were purchased from Merck, Sigma Aldrich, Riedel-de Haën and used without purification. Reactions were monitored through pre-coated TLC plates of silica gel (Merck 60 F254, 0.2 mm thick) and spots were examined under UV light (CAMAG Scientific Inc) at 254/365 nm. Column chromatograp... | Results and discussion
Chemistry of spiropyrazoline-indolinones
New spiropyrazoline-indolinones (4a–4t) were synthesized using DES as a catalyst in addition to its role as reaction media. The multicomponent reaction proceeded with 5-Cl or 5-Br isatin ( 1a/1b ), acetophenone or 2-acetyl thiophene ( 2a / 2b ) and diffe... | Results and discussion
Chemistry of spiropyrazoline-indolinones
New spiropyrazoline-indolinones (4a–4t) were synthesized using DES as a catalyst in addition to its role as reaction media. The multicomponent reaction proceeded with 5-Cl or 5-Br isatin ( 1a/1b ), acetophenone or 2-acetyl thiophene ( 2a / 2b ) and diffe... | Conclusion
In summary, highly functionalized new spiropyrazoline-indolinones have been developed through a facile, one-pot two-step, multicomponent green methodology. This protocol features catalyst-free conditions, green solvents, mild reaction conditions, easy work-up with high yield, and short reaction time. The tri... | Novel spiropyrazoline-indolinones ( 4a–t ) have been synthesized successfully in neutral deep eutectic solvents by reacting 5-Cl/Br-isatin ( 1a–b ) with aromatic ketones ( 2a–b ) and a variety of substituted hydrazines ( 3a–e ) in good to excellent yields. This eco-friendly straightforward synthetic protocol discloses ... | Research funding
This research was funded by Princess Nourah bint Abdulrahman University Researchers Supporting Project number (PNURSP2024R158), 10.13039/501100004242 Princess Nourah bint Abdulrahman University, Riyadh, Saudi Arabia . The authors extend their appreciation to the Deanship of Scientific Research at 10.... | Supplementary data
The following is the Supplementary data to this article:
Acknowledgements
The authors extend their appreciation to the Deanship of Scientific Research at 10.13039/501100007446 King Khalid University for funding this work through large group Research Project under grant number RGP.2/575/44. The auth... | CC BY | no | 2024-01-16 23:43:42 | Heliyon. 2023 Dec 20; 10(1):e23814 | oa_package/98/45/PMC10788502.tar.gz |
PMC10788504 | 38226174 | Introduction
Brain-computer interfaces (BCIs) constitute a promising tool for establishing direct communication and control from the brain over external effectors for clinical applications. 1 , 2 However, the ideal features to design a BCI are unknown, since the underlying microscopic brain processes and their reflect... | STAR★Methods
Key resources table
Resource availability
Lead contact
Marie-Constance Corsi ( marieconstance.corsi@icm-institute.org ).
Materials availability
Given the personal nature of the data, it is not possible to make it public now. However, the data is available upon request to the corresponding authors for t... | Results
We used the spatiotemporal spreading of large aperiodic bursts of activations as a proxy for communications between pairs of regions. Within this framework, large-scale, higher-order perturbations are considered to mediate the interactions between brain regions. We tested for differences between the two experim... | Discussion
In this work, we set out to test if neuronal avalanches can track subject-specific changes induced by the execution of a task (i.e., hand motor imagery) in the large-scale brain dynamics. The working hypothesis was that meaningful communication among regions on the large-scale is intermittent, and it is best... | These authors contributed equally
These authors contributed equally
Lead contact
Summary
Large-scale interactions among multiple brain regions manifest as bursts of activations called neuronal avalanches, which reconfigure according to the task at hand and, hence, might constitute natural candidates to design brain-com... | Supplemental information
Acknowledgments
The authors acknowledge support from 10.13039/501100000781 European Research Council ( 10.13039/100017325 ERC ) under the European Union’s 10.13039/501100007601 Horizon 2020 research and innovation program (grant agreement No. 864729); the program “Investissements d’aven... | CC BY | no | 2024-01-16 23:43:43 | iScience. 2023 Dec 14; 27(1):108734 | oa_package/4d/a9/PMC10788504.tar.gz | ||
PMC10788512 | 38226284 | Introduction
Over the last hundred years, globalization has created a geographically concentrated production system in which certain areas of the planet now operate as engines of the entire world's gross domestic production (GDP). This agglomeration of production activity has led to new trends in economic geography in ... | Discussion of the results
Previous literature reported a persistent and growing gap between rich and poor countries across the world during the second half of the twentieth century. In addition, in developing countries the gap in personal income distribution, specifically between the rich and the poor, also increased. ... | Discussion of the results
Previous literature reported a persistent and growing gap between rich and poor countries across the world during the second half of the twentieth century. In addition, in developing countries the gap in personal income distribution, specifically between the rich and the poor, also increased. ... | Conclusions
Economic globalization has concentrated production in a limited number of countries and regions around the world. Indeed, adapting production processes to a globally organized setting has led to substantial changes in economic geography so that nowadays just a few regions are driving the world's entire GDP.... | Economic globalization has led to production increasingly becoming concentrated in certain regions and countries of the world. This article develops an accounting framework to provide the trends for the contribution of countries to global gross domestic production (GDP). In particular, the method transforms the multire... | Modeling framework
Global GDP in the two-country case
The starting point for analyzing the contribution of countries to world production is the multiregional input-output framework, which explicitly captures the economic connections between countries throughout the sectoral inputs and outputs circulating worldwide. Com... | Acknowledgements
Useful and constructive comments by three anonymous referees and by the editor of the journal have substantially improved an earlier version of this article. Funding by the 10.13039/501100007512 Universitat Rovira i Virgili (PFR2022) is also acknowledged. | CC BY | no | 2024-01-16 23:43:44 | Heliyon. 2023 Dec 19; 10(1):e23909 | oa_package/e9/bc/PMC10788512.tar.gz | |
PMC10788513 | 38226288 | Introduction
In recent decades, renal cell carcinoma (RCC) has emerged as a global health concern due to its increasing incidence and resulting status as the primary cause of death among urological malignancies [ 1 ]. Clear cell renal cell carcinoma (ccRCC), representing the most common RCC subtype, is particularly cha... | Materials and methods
Data collection and prognosis analysis
We sourced expression profiles and clinical data of KIRC, KIRP, and KICH from The Cancer Genome Atlas (TCGA) database. Additionally, we obtained expression data of an immunotherapy cohort undergoing anti-PD-1 therapy (nivolumab) in RCC from the Gene Expressio... | Results
STX4 is positively correlated with poor prognosis in ccRCC
From the TCGA database, we observed a significant increase in STX4 expression in ccRCC ( Fig. 1 A). Patients demonstrating high STX4 expression had notably reduced OS, PFS, and DSS compared to those with low STX4 expression ( Fig. 1 B). We further inves... | Discussion
Currently, continuous progress in understanding renal cell tumor biology has resulted in the development of molecular therapies aimed at the VEGF and mTOR pathways [ 35 , 36 ]. Concurrently, the emergence of immune checkpoint inhibitors has added another therapeutic option for patients with advanced ccRCC [ ... | Conclusions
In conclusion, we validated the disparity in the expression of STX4 and its prognostic value in ccRCC. In vitro tests were conducted to examine the cancer-promoting role of STX4 in ccRCC. Additionally, we evaluated the correlations between patient response to immunotherapy, targeted therapies, and STX4 expr... | These authors contributed to this work equally and shared first authorship.
Clear cell renal cell carcinoma (ccRCC) represents a frequent subtype of kidney cancer, with the prognosis remaining poor for individuals with metastatic disease. Given its resistance to both radiation and chemotherapy, targeted therapies and i... | Data availability statement
Data will be made available on request, and all the data can be obtained by contacting the corresponding author.
CRediT authorship contribution statement
Kai Zeng: Writing – review & editing, Investigation. Qinyu Li: Writing – review & editing, Investigation. Xi Wang: Writing – review &... | Supplementary data
The following is/are the supplementary data to this article.
Acknowledgements
The funding for this research was provided by several grants. This included grants from the 10.13039/501100001809 National Natural Science Foundation of China (grant numbers 81902619 and 82360606), the Wuhan Shuguang Proj... | CC BY | no | 2024-01-16 23:43:44 | Heliyon. 2023 Dec 21; 10(1):e23918 | oa_package/18/7b/PMC10788513.tar.gz |
PMC10788514 | 38226246 | Introduction
Soil erosion is generally viewed to be the result of a confluence of natural factors and human activities [ 1 ]. With global warming, extreme rainfall and severe weather are becoming more and more frequent. Extreme rainfall events lead to soil nutrient depletion and destruction and loss of land productivit... | Materials and methods
Study area
Considering the ancient Yellow River flood distribution, and reference to relevant literature [ 36 , 37 ], 20 prefecture-level cities of Henan and Shandong provinces were selected as AALYR. Among them, Laiwu was assigned to Jinan in 2019. In this paper, it is attributed to Jinan for ana... | Results
Spatiotemporal characteristics of soil erosion in AALYR
Spatial pattern of soil erosion factors
RUSLE for assessing soil erosion is composed of R , K , LS , C , and P factors. R is mainly caused by heavy rainfall, reflecting the influence of rainfall. Factor K reflects soil erodibility and soil erosio... | Discussion
The soil erosion in AALYR from 2000 to 2020 is estimated by RUSLE, and the results show that the erosion grade is mainly very slight, and the severe and above erosion grades are mainly distributed in Zibo, Jinan, Anyang, Zhengzhou and Tai 'an. The common feature of these cities with serious erosion is that t... | Conclusions
With the increasing impact of global warming and human disturbance, soil erosion has become a serious and lasting environmental challenge affecting ecological construction and social economic development [ 71 ]. The high-quality development of AALYR has very important strategic significance for the developm... | With the accelerated development of urbanization, the exploration and usage of land resources is becoming more and more frequent, which leads to the decline of soil quality, resulting in a series of soil ecological issues, such as soil nutrient loss, soil quality degradation and destruction. At present, the contradicti... | Data availability statement
Data will be made available on request.
CRediT authorship contribution statement
Ying Zhang: Writing – original draft, Methodology. Pengyan Zhang: Writing – review & editing, Project administration, Funding acquisition. Zhenyue Liu: Software. Guangrui Xing: Software. Zhuo Chen: Writ... | Supplementary data
The following is the Supplementary data to this article:
Acknowledgements
This research was funded by the 10.13039/501100001809 National Natural Science Foundation of China , grant number 41601175, 41801362, 2022 Program for Youth Talent of Zhongyuan , 2023 Funding for the Construction of Key Labo... | CC BY | no | 2024-01-16 23:43:44 | Heliyon. 2023 Dec 20; 10(1):e23819 | oa_package/14/b9/PMC10788514.tar.gz |
PMC10788515 | 38226237 | Introduction
Water is essential to life and water pollution and the introduction of toxic substances to water bodies such as lakes, rivers, oceans, and so on, getting dissolved in them, lying suspended in the water, or depositing on the bed [ 1 ], represents one of the most serious ecological threats. The main aim of t... | Materials and methods
System dynamics models provide an invaluable means of comprehending complex systems [ 54 ]. These mathematical representations of interactions and feedback loops within a system enable researchers to simulate and predict its behavior over time [ 55 ]. When applied to tourism-induced water pollutio... | Results
The growing interest in SD modelling in tourism is significant. The majority (91F) of studies were published within the last decade (2012–2023), and over half of them (54 %) between 2018 and 2023. Notably, 2007, 2009, 2012, and 2021 stand out with zero publications, hinting at potential gaps or reduced research... | Discussion and summary
Research released the general situation regarding SD modelling of tourism-induced pollution and degradation of water resources and aquatic ecosystems, which is illustrated by a general scheme ( Fig. 3 ). The need to balance tourism development with environmental protection was identified as the m... | Conclusions
A review of SD in tourism has already been presented by Ref. [ 66 ] that demonstrated the effectiveness of system dynamics models for planning and making decisions in the tourism industry, identifying externalities driven by tourism, and forecasting both its positive and negative effects. Based on their stu... | This study delves into the intricate dynamics of tourism-induced water pollution through a systematic literature review, aiming to unravel complexities using a system dynamics (SD) modeling approach coupled with the PRISMA analysis methodology. Employing a comprehensive PRISMA analysis of 68 pertinent articles, the stu... | Funding
The financial support of the Specific Research Project Information and Knowledge Management and Cognitive Science in Tourism of FIM UHK is gratefully acknowledged.
Data availability statement
The data supporting the findings of this study are available upon request. Requests for access to the data can be direct... | Appendix
Acknowledgments
The authors wish to express their thanks to Zuzana Kroulíková, FIM UHK student, who assisted with the graphical elements. | CC BY | no | 2024-01-16 23:43:44 | Heliyon. 2023 Dec 20; 10(1):e23824 | oa_package/e4/bb/PMC10788515.tar.gz |
PMC10788522 | 38142520 | Introduction
Autonomic nervous system function is regulated by widely ramified networks of the central nervous system involving the brain and the spinal cord. Key areas encompass preganglionic sympathetic neurons from T1 to L2 thoracolumbar segments, the nucleus of the solitary tract, the rostral ventrolateral medulla ... | Materials and methods
Subjects and study design
Stroke patients
Patients with acute first-ever ischemic stroke at any cortical localization (n = 42; 16 women; mean age 65.7 ± 13.1 y; 2–7 days post-stroke) were recruited from the Department of Neurology, University Medical Center Mainz (Mainz, Germany) as part of a sing... | Results
Clinical characteristics of stroke patients
Patient demographic characteristics, stroke location and size, and medical history are displayed in Table 1 . Mean lesion volume was 11.23 ml, range 0.14–97.5 ml. The National Institutes of Health Stroke Scale (NIHSS) mean score after acute medical/surgical intervent... | Discussion
Acute brain lesions might cause significant disturbances of cardiac autonomic function that eventually lead to increased mortality and poor functional outcome ( Lees et al., 2018 ). Given the robustness of the autonomic control of heart rate, which is necessary for survival, and the multitude of brain areas ... | Conclusion
In conclusion, our results indicate that an interaction of brain lesions with existing resting state brain networks predicts the impairment of HRV after stroke, rather than the brain lesion itself. | These authors contributed equally to this work.
Highlights
• Acute cerebral stroke leads to abnormal reductions in low frequency bands of HRV. • Associated lesions location in the right temporo-parieto-occipital cortex, basal ganglia, thalamus, and interconnections. • Acute brain lesions related to abnormal HRV impact ... | Limitations
We acknowledge that our study has limitations: 1) The right hemispheric dominance of the lesions in our sample could be affected by sampling bias. Acute left-sided strokes often suffer from aphasia precluding participation in scientific studies. 2) We do not have an explanation for reduced VC in our patient... | Supplementary data
The following are the Supplementary data to this article:
Data availability
Data will be made available on request.
Acknowledgment
The authors thank Dr. Cheryl Ernest for proofreading and editing the manuscript. | CC BY | no | 2024-01-16 23:43:44 | Neuroimage Clin. 2023 Dec 19; 41:103558 | oa_package/bd/69/PMC10788522.tar.gz |
PMC10788524 | 38226210 | Introduction
background
Gastrointestinal (GI) cancer is one of foremost cancer-related public health problem worldwide with greatly characterized by poor prognosis. . GI cancers account for approximately 5 million new cases of cancers and 3 million deaths worldwide in 2020. The highest liver, esophageal, and gastric ca... | Conclusion
Hippo signaling pathway is well-known as one of the most imperative pathways that contribute into the regulation of various cellular processes, including cell differentiation, migration and proliferation. Dysregulation of Hippo pathway resulted from aberrant expression of the corresponding molecular effector... | Co-author.
Long non-coding RNAs (lncRNAs) play a significant biological role in the regulation of various cellular processes such as cell proliferation, differentiation, apoptosis and migration. In various malignancies, lncRNAs interplay with some main cancer-associated signaling pathways, including the Hippo signaling... | cross-talk between lncRNAs and the Hippo signaling pathway in gastrointestinal cancers
Functional and mechanistic studies have been confirmed that several lncRNAs maigh regulate Hippo signaling pathway through targeting some molecular effectors. Hippo pathway cascades also reciprocally might regulate the lncRNAs synthe... | Abbreviations
CTGF connective tissue growth factor CYR61 cysteine-rich 61 GI gastrointestinal HNSCCs head and neck squamous cell carcinomas MST1/MST2 mammalian STE20-like protein kinase 1/2 LATS1/2 large tumor suppressor 1/2 (and LATS2) YAP Yes-associated protein TAZ transcriptional co-activator with PDZ-binding moti... | CC BY | no | 2024-01-16 23:43:44 | Heliyon. 2023 Dec 22; 10(1):e23826 | oa_package/a9/1a/PMC10788524.tar.gz | |||
PMC10788526 | 38226256 | Background
Monkeypox virus (mpox) is an Orthopoxvirus genus, including variola virus, mainly prevalent in tropical forests of Central and Western Africa, responsible for a new outbreak in non-endemic regions with 86956 cases worldwide on the 17 th of April 2023 [ 1 ]. So far, around 957 cases have been reported in Ita... | Discussion
This case report discusses a rare but severe cardiac complication of mpox infection in an individual living with HIV. Although the incidence is unknown, mpox life-threatening complications such as severe pneumonia, encephalitis, and myocarditis encephalitis seem rare. Myopericarditis is an inflammatory condi... | Conclusions
Cardiac complications are possible severe complications of mpox infection with very few described cases in the literature. The report emphasizes the importance of considering multiple factors and potential co-infections in complex clinical cases like this. Tecovirimat, an antiviral developed for the treatme... | Both authors have contributed equally.
Cardiac involvement, such as myocarditis and pericarditis, can be a severe complication of monkeypox virus (mpox) infection and could be related to other co-infections with cardiac involvement. Tecovirimat is an antiviral specifically designed to inhibit smallpox infection diffusi... | Case presentation
Background
In this case study, we describe the complex clinical presentation of a 42-year-old Caucasian man who has sex with men living with HIV-1 for almost 12 years, regularly on follow-up at the HIV clinic, Careggi University Hospital. He had been successfully managed with antiretroviral therapy an... | CC BY | no | 2024-01-16 23:43:45 | Heliyon. 2023 Dec 21; 10(1):e23965 | oa_package/4e/f3/PMC10788526.tar.gz | |||
PMC10788527 | 38226398 | Introduction
Acinetobacter baumannii is the is the fourth most commonly occurring micro-organism in bloodstream infections (BSIs) associated with central venous catheter (CVC) in Brazil [ 1 ]. Infections caused by multi-resistant A. baumannii that produce oxacillinase-type carbapenemases (OXA) are currently consider... | Methods
An in-vitro experimental study tested three disinfection procedures on two different NCs artificially contaminated with a strain of A. baumannii bla OXA-23 LA216 [ 13 ].
The NCs used in this study were the two-way intermediate extender's hub (Polifix®, B. Braun), and the needle-free valve (Safeflow®, B. Braun... | Results
Of the 90 experiments conducted, 82 were considered for the findings as eight technical outliers were excluded. All the negative controls displayed the sterilization of the materials used in the research. Thirty-seven experiments were performed using two-way intermediate extender's hub, while the needle-free va... | Discussion
In this in-vitro study, all the tested disinfection procedures were efficacious in reducing the A. baumannii bla OXA-23 load in NCs in a controlled environment. This is important because A . baumannii bla OXA-23 is an opportunistic pathogen, that can survive for extended periods in hospital settings, es... | Summary
Aim
This study aimed to verify the efficacy of disinfection procedures to reduce Acinetobacter baumannii bla OXA-23 bacterial load in needleless connectors that had been experimentally contaminated.
Methods
Two-way intermediate extender's hub and needle-free valve were contaminated with Acinetobacter baumann... | CRediT author statement
Camila Biazus Dalcin: Conceptualization, Methodology, Investigation, Formal analysis, Writing - Original Draft, Review & Editing.
Thaís Cristine Marques Sincero: Methodology, Formal analysis, Writing - Review & Editing.
Caetana Paes Zamparette: Methodology, Formal analysis, Writing - Review ... | Supplementary data
The following is the Supplementary data to this article:
Acknowledgements
The team would like to acknowledge Dr Thaís Cristine Marques Sincero, Laboratory of Applied Molecular Microbiology (MIMA) at the Federal University of Santa Catarina (UFSC), Brazil, for the donation of the ATCC strain and some... | CC BY | no | 2024-01-16 23:43:45 | Infect Prev Pract. 2023 Dec 1; 6(1):100328 | oa_package/70/39/PMC10788527.tar.gz | |
PMC10788531 | 38000659 | Results
Creation of dCas9-CtBP chimeras to regulate gene expression
To investigate the function of the CtBP C-terminal IDR and differences in gene regulation by the CtBP(L) and CtBP(S) isoforms in Drosophila , we employed CRISPRi ( 17 ). These two isoforms are created through alternative splicing, with CtBP(L) having ... | Discussion
Here, we created novel dCas9-chimeras to CtBP corepressor proteins to compare their impact on gene expression in an in vivo system. Our study of Drosophila CtBP(L) and CtBP(S) isoforms using this CRISPRi approach has revealed that the two isoforms of this corepressor do exhibit different functional poten... | The C-terminal binding protein (CtBP) is a transcriptional corepressor that plays critical roles in development, tumorigenesis, and cell fate. CtBP proteins are structurally similar to alpha hydroxyacid dehydrogenases and feature a prominent intrinsically disordered region in the C terminus. In the mammalian system, Ct... | Eukaryotic transcription factors and cofactors are rich in unstructured domains; these proteins have a higher percentage of predicted intrinsically disordered regions (IDRs) than the average protein ( 1 ). Some of these IDRs have been shown to participate in specific transcriptional processes, sometimes through promoti... | Supporting information
Acknowledgments
We would like to thank members of the Arnosti lab for their thoughtful suggestions and the Michigan State University RTSF and plasmidsaurus for sequencing plasmids.
Author contributions
A.-M. R. and D. N. A. conceptualization; A.-M. R., M. S. methodology; A.-M. R. data analysi... | CC BY | no | 2024-01-16 23:43:45 | J Biol Chem. 2023 Nov 23; 300(1):105490 | oa_package/01/c5/PMC10788531.tar.gz | |||
PMC10788534 | 38043798 | Results
Identification of NOTCH1 proximal interacting proteins using BioID in HEK293 cells
Strong gain-of-function mutations in NOTCH1 leading to ligand-independent accumulation of NICD in the nucleus is a common event in human cancers, and expression of a truncated NICD in many different cell types in mice can drive s... | Discussion
We have applied an innovative and alternative approach to define the biochemical composition of the nuclear Notch complexes in live cells. Our BioID study has complemented previous characterization of NICD partners and PPIs using conventional low or high throughput methods such as reconstituted complex, yeas... | Notch signaling plays a critical role in cell fate decisions in all cell types. Furthermore, gain-of-function mutations in NOTCH1 have been uncovered in many human cancers. Disruption of Notch signaling has recently emerged as an attractive disease treatment strategy. However, the nuclear interaction landscape of the o... | Notch signaling is an evolutionarily conserved intercellular communication mechanism across invertebrates and vertebrates that regulate cell fate determination, proliferation, differentiation, and death programs ( 1 ). In normal mammalian cells, there are four Notch receptors (named Notch1-Notch4), which are single pas... | Supporting information
Acknowledgments
We thank members of the Tao Lab for critical reading of the manuscript and Bethany Mordhorst for scientific and software technical discussions. We thank L-J Pilaz and KC Pratiksha for sharing reagents. We also thank Alexandre Campos and the Sanford Burnham Prebys Pro... | CC BY | no | 2024-01-16 23:43:45 | J Biol Chem. 2023 Dec 1; 300(1):105522 | oa_package/84/f1/PMC10788534.tar.gz | |||
PMC10788540 | 37992807 | Results
tACE is required for normal ATP production in sperm
To assess the effect of tACE on mouse sperm metabolism, we first determined the levels of intermediate metabolites in CKO and WT sperm by mass spectrometry ( 20 ). We found that 64 metabolites were significantly different between CKO and WT sperm ( p < 0.01).... | Discussion
Sperm motility and function are governed by cellular ATP levels, and mitochondrial dysfunction suppresses sperm motility ( 33 ). There are two major metabolic pathways, glycolysis and oxidative phosphorylation, to generate ATP in sperm. Oxidative phosphorylation occurs in the midpiece, while glycolysis occur... | Testis angiotensin-converting enzyme (tACE) plays a critical role in male fertility, but the mechanism is unknown. By using ACE C-domain KO (CKO) mice which lack tACE activity, we found that ATP in CKO sperm was 9.4-fold lower than WT sperm. Similarly, an ACE inhibitor (ACEi) reduced ATP production in mouse sperm by 72... | Angiotensin-converting enzyme (ACE) is a zinc-dependent dipeptidyl carboxypeptidase. There are two isoforms of ACE: somatic ACE (sACE) and testicular ACE (tACE). These isoforms are transcribed from the same gene through the action of alternative promoters. sACE is composed of two homologous catalytic domains (N domain ... | Supporting information
Acknowledgments
We thank Proteomic and Metabolomics Core team at Cedars-Sinai for performing metabolites and MitoPlex array.
Author contributions
T. S., S. A. B., D. Y. C., S. S., E. N., J. F. G., and Z. K. investigation; T. S. and Z. K. methodology; T. S., K. E. B, and Z. K. formal a... | CC BY | no | 2024-01-16 23:43:45 | J Biol Chem. 2023 Nov 20; 300(1):105486 | oa_package/65/03/PMC10788540.tar.gz | |||
PMC10788541 | 38016514 | For many decades, our understanding of G protein-coupled receptor (GPCR) activity and cyclic AMP (cAMP) signaling was limited exclusively to the plasma membrane. However, a growing body of evidence has challenged this view by introducing the concept of endocytosis-dependent GPCR signaling. This emerging paradigm emphas... | The beginning
Adenylyl cyclase (AC) and its product, adenosine 3',5′-cyclic monophosphate (cAMP), were initially identified by Earl W. Sutherland's group during investigations into the mechanism of action of the hyperglycemic hormones, epinephrine and glucagon ( 1 , 2 ). They discovered that hormone-stimulated AC acti... | Acknowledgments
The references incorporated into this review were chosen with a focus on their pertinence to the subjects discussed in this article. Emphasis was placed on seminal research, recent progress, and works that elucidated fundamental principles within the parameters of this review. Nonetheless, it is importa... | CC BY | no | 2024-01-16 23:43:45 | J Biol Chem. 2023 Nov 26; 300(1):105497 | oa_package/4b/06/PMC10788541.tar.gz | |||||
PMC10788543 | 38072063 | Statistical methods
GraphPad Prism 9.0 (GraphPad Software, Inc) was used to generate graphs and perform statistical analysis in this study. We used the unpaired two-tailed t test for comparisons between two groups and one-way ANOVA for multigroup comparisons. p < 0.05 was considered statistically significant. | Results
Ent and the iron-responsive exometabolome in UPEC
To define the iron-responsive exometabolome of UPEC and its relationship to the ent- encoded biosynthetic pathway, we compared small molecule profiles in conditioned media from the model UPEC strain UTI89 and its isogenic biosynthesis-deficient mutant, UTI89Δ e... | Discussion
Multiple bacterial siderophore systems release exometabolites in addition to their canonical biosynthetic end products. Here, we find that UPEC have the potential to hydrolyze Ent trimers to recover raw materials for new biosynthesis, yet limit this process to instead generate and secrete incompletely hydrol... | Uropathogenic Escherichia coli (UPEC) secrete multiple siderophore types to scavenge extracellular iron(III) ions during clinical urinary tract infections, despite the metabolic costs of biosynthesis. Here, we find the siderophore enterobactin (Ent) and its related products to be prominent components of the iron-resp... | Urinary tract infections (UTIs) are among the most common outpatient and inpatient infections encountered by physicians ( 1 , 2 , 3 , 4 ). Escherichia coli is the bacterial species most commonly associated with UTI, accounting for about 70 to 95% of clinical cases ( 5 , 6 ). Clinical E. coli isolates associated... | Supporting information
Author contributions
Z. Z. and J. P. H. conceptualization; Z. Z., J. I. R., and L. K. S. methodology; Z. Z. investigation; Z. Z. writing–original draft; J. P. H. writing–review & editing; Z. Z. visualization; J. P. H. supervision; J. P. H. funding acquisition.
Funding and additional informati... | CC BY | no | 2024-01-16 23:43:45 | J Biol Chem. 2023 Dec 10; 300(1):105554 | oa_package/91/40/PMC10788543.tar.gz | ||
PMC10788561 | 38043801 | Results
Characteristics of putative S. constricta opsins and Gα proteins
Initially, a total of 28 opsin-like sequences (named Sc_opsin1 - 28 ) were screened from the S. constricta genome. Following the removal of sequences with a similarity of over 98% and those lacking 7 TM helixes, a final set of 23 opsin homo... | Discussion
Marine bivalves represent a highly diverse and evolutionarily successful group of organisms in the marine ecosystem. Confronted with the challenging light environment, these organisms have evolved a wide range of photoreceptor organs ( 39 ), making them a valuable source for studying the evolutionary adaptat... | Phototransduction is based on opsins that drive distinct types of Gα cascades. Although nonvisual photosensitivity has long been known in marine bivalves, the underlying molecular basis and phototransduction mechanism are poorly understood. Here, we introduced the eyeless razor clam Sinonovacula constricta as a model... | Light is a crucial environmental factor that impacts both terrestrial and aquatic ecosystems on Earth. Consequently, light perception plays a critical role in the development and survival of the entire animal kingdom. For example, visual photosensitivity enables animals to identify mates, predators, and preys, while no... | Supporting information
Author contributions
F. K. conceptualization; F. K. investigation; F. K. writing-original draft; Z. S. R. and J. L. X. supervision; Z. S. R. and J. L. X. resources; Z. S. R. and J. L. X. funding acquisition; Z. S. R., M. Q. Z., and K. L. formal analysis; Z. S. R., M. Q. Z., and K. L. validati... | CC BY | no | 2024-01-16 23:43:45 | J Biol Chem. 2023 Dec 1; 300(1):105527 | oa_package/75/51/PMC10788561.tar.gz | |||
PMC10788580 | 38221782 | INTRODUCTION
Skin photoaging is characterized by roughness, dryness, uneven color, and wrinkles caused by long‐term ultraviolet radiation on the skin. 1 Photoaging is also a potential risk factor for various skin inflammatory, immune, and neoplastic diseases. 2 A convenient, rapid, and accurate diagnostic met... | MATERIALS AND METHODS
Donors
From January to June 2021, 40 patients underwent surgery in the Department of Dermatology, Burns, Orthopedics, and Plastic Surgery of the Second Affiliated Hospital of Kunming Medical University. Their skin samples were collected from the face, elbow extension, outer calf, armpit, abdomen, ... | RESULTS
Clinical and pathological donor data
The 40 donors included 25 males and 15 females. The general information, Fitzpatrick classification, clinical grading of photoaging (Figure 1A–C ), pathology, and immunohistochemistry (Figure 1G–L ) of the donors are displayed in Tables 1 and 2 . For the convenience of ... | DISCUSSION
Skin aging can be caused by external factors such as ultraviolet radiation, smoking, and exposure to harmful chemicals. Ultraviolet radiation has the most potent effect on the exogenous factors leading to skin aging, and aging caused by ultraviolet radiation is called photoaging. 16 Compared with endoge... | Abstract
Background
There are no standards for evaluating skin photoaging. Dermoscopy is a non‐invasive detection method that might be useful for evaluating photoaging.
Objective
To assess the correlation between the dermoscopic evaluation of photoaging and clinical and pathological evaluations.
Methods
The age, clinic... | METHODS
Clinical and dermoscopic evaluation of photoaged skin
Before surgery, clinical and dermoscopic photographs (DermLite DL4 portable dermoscopy) were taken from the surgical sites, and the Fitzpatrick classifications of the donors were recorded. 10 Clinical evaluation of photoaging was conducted using the Glo... | ACKNOWLEDGMENTS
This study was supported by the National Natural Science Foundation of China (No. 81960568), Ten Thousand Talent Plans for Young Top‐notch Talents of Yunnan Province (No. YNWR‐QNBJ‐2020‐264), Medical Reserve Talents of Yunnan Health Commission (No. H‐2019033) and Yunnan Technology Talent and Platform Pl... | CC BY | no | 2024-01-16 23:43:47 | Skin Res Technol. 2024 Jan 14; 30(1):e13578 | oa_package/6b/97/PMC10788580.tar.gz | |
PMC10788587 | 37715348 | INTRODUCTION
Many people with wounds initially seek care from their community‐based healthcare providers (CHPs) who are often not specialised in wound care. 1 , 2 , 3 , 4 Wounds are also initially treated by individuals themselves and their circles of care. 2 , 5 Despite the rapidly growin... | METHODS
An advisory panel of QWCP experts met to discuss and develop simplified recommendations for managing HTHWs. The sponsor of this panel, 3M Health Care, invited panel members based on their clinical experience in wound care. Panel members were selected from Europe, North America, Australia and Africa. The advisor... | RESULTS
Following is a description of HTHWs along with practical, evidence‐based SOC wound care recommendations developed by panel members for any CHP who provides wound care. Instituting these recommendations into practice could make giant strides towards HTHW prevention and positive treatment outcomes.
Healing versus... | DISCUSSION
Increases in age‐ and lifestyle‐associated conditions including diabetes, obesity and vascular disease as well as healthcare system resource limitations have contributed to a global rise in the prevalence of hard‐to‐heal wounds. Curbing the humanistic and financial burden of HTHWs increasingly involves CHPs ... | Abstract
It is common for community‐based healthcare providers (CHPs)—many of whom have not received specialised training in wound care—to deliver initial and ongoing management for various wound types and diverse populations. Wounds in any setting can rapidly transition to a stalled, hard‐to‐heal wound (HTHW) that is ... | CONFLICT OF INTEREST STATEMENT
Dimitri Beeckman, Emily Greenstein, Patricia Idensohn, Robert Klein, Norbert Kolbig, Kimberly LeBlanc, Catherine Milne, Terry Treadwell, Dot Weir and Wendy White are all paid consultants for 3M. Matthew Cooper is an employee of 3M. | ACKNOWLEDGEMENTS
The authors thank Karen Beach (3M) for assistance with manuscript preparation.
DATA AVAILABILITY STATEMENT
Data sharing not applicable to this article as no datasets were generated or analysed during the current study. | CC BY | no | 2024-01-16 23:43:47 | Int Wound J. 2023 Sep 15; 21(1):e14402 | oa_package/ba/1b/PMC10788587.tar.gz | |
PMC10788588 | 38226397 | INTRODUCTION
In endoscopy training, trainees typically learn through didactic lectures and apprenticeships. However, this method of procedural training is often unstandardized; it results in variable technical skills depending on the expertise of the supervising physician. 1 Opportunities for training are also hig... | METHODS
Participants
We conducted an upper endoscopy training program for novice trainees (1st year GI fellows). The trainees were recruited from seven academic medical centers in San Francisco, US; Singapore, Singapore; Manila, Philippines; Jakarta, Indonesia; and Bangkok, Thailand (Figure 1 ). The course was conduct... | RESULTS
We enrolled 21 novice trainees in our training program (Table 1 ). Most trainees had no prior experience performing EGD or colonoscopy in patients. All trainees ( n = 21, 100%) completed the training program and met the MPS for endoscope handling, standard EGD examination, photo‐documentation, and biopsy. For... | DISCUSSION
In the 1980s, a renowned educational psychologist, Benjamin Bloom, described a breakthrough learning method that combined mastery learning and intensive one‐on‐one mentoring. 17 The students performed 98% better (on average) than those who learned using the traditional method. This increase in learning ... | Abstract
Introduction
Our simulation‐based mastery learning (SBML) curriculum, delivered in person, has been shown to successfully train novices in structured esophagogastroduodenoscopy (EGD). SBML with virtual coaching (VC) has the potential to improve the effectiveness and efficiency of endoscopy training and expand ... | CONFLICT OF INTEREST STATEMENT
Tonya R. Kaltenbach: Consultant for Verily Life Sciences and Research Support from Olympus. Roy M. Soetikno: Consultant for Olympus and Fujifilm. Amandeep Shergill: Consultant for Boston Scientific. The remaining authors declare no conflict of interest. | CC BY | no | 2024-01-16 23:43:47 | DEN Open. 2024 Jan 14; 4(1):e317 | oa_package/3c/78/PMC10788588.tar.gz | ||
PMC10788594 | 37933591 | INTRODUCTION
Cassava ( Manihot esculenta ) is an important tropical crop with annual production of about 315 million tonnes in over 30 million hectares. Africa accounts for 65% of the total global cassava production, with Nigeria being one of the major producers, contributing up to 20% the global total (FAOSTAT, 2022 ... | CONCLUSIONS
Cassava, which is a major food security crop for millions of people in Africa and other tropical regions, faces a challenge posed by viral diseases, which have remained the primary cause of the crop's low productivity. Observed breakdown in resistance for some traits, such as CMD resistance, requires a regu... | Abstract
Cassava ( Manihot esculenta ) is one of the most important sources of dietary calories in the tropics, playing a central role in food and economic security for smallholder farmers. Cassava production is highly constrained by several pests and diseases, mostly cassava mosaic disease (CMD) and cassava brown stre... | CASSAVA DISEASES AND PESTS
Cassava production is mainly constrained by two viral diseases, CMD and CBSD (Figure 2 ). These viruses are transmitted by insect vectors, mainly whitefly ( Bemisia tabaci ), and stem cuttings as planting materials (Legg et al., 2002 ). CMD is caused by viruses of the family Geminiviridae ... | ACKNOWLEDGEMENTS
The authors wish to thank the CGIAR Roots, Tubers and Banana Program.
DATA AVAILABILITY STATEMENT
Data sharing is not applicable to this article as no new data were created or analysed. | CC BY | no | 2024-01-16 23:43:47 | Mol Plant Pathol. 2023 Nov 7; 25(1):e13402 | oa_package/f4/37/PMC10788594.tar.gz | |||
PMC10788595 | 38226125 | Introduction
Human immunodeficiency virus (HIV) infection first appeared in 1981 in the United States through manifestations of opportunistic infections or neoplasms in young men who had sex with men or who used intravenous drugs [ 1 ]. Epidemiologically, HIV infection has so far been responsible for more than half a m... | Discussion
Vasculitic manifestations of shingles are rare and often associated with a severe prognosis. They generally affect the cerebral vessels and can cause damage to large and small vessels [ 6 ]. Shingles can affect both the central nervous system, causing encephalitis, and the peripheral nervous system, leading ... | Conclusions
In our case, shingles was a harbinger of HIV infection. The patient was diagnosed with secondary leukocytoclastic vasculitis, which manifested as a vasculitic-like rash and hemorrhagic vesicles. In the absence of the patient's SARS-CoV-2 immunization, which could have exacerbated the lymphopenia and acceler... | Herein, we report the case of a 69-year-old patient who presented to our dermatology clinic for a skin eruption characterized by grouped hemorrhagic vesicles and erosions covered by hemorrhagic crusts on an erythematous background located on the lower right limb. The lesions were small, clustered, and variable in size ... | Case presentation
The initial nonspecific clinical picture with an influenza-like syndrome, the long period of the viral set point that can last for years, as well as the subsequent polymorphic manifestations, make the diagnosis of HIV infection challenging. Skin manifestations are one of the most common complications ... | The authors acknowledge Dr. Leventer Medical Center and Dr. Tiberiu Tebeica for their help in obtaining and interpreting the histopathological images. | CC BY | no | 2024-01-16 23:43:47 | Cureus.; 15(12):e50609 | oa_package/1f/d4/PMC10788595.tar.gz | ||
PMC10788596 | 38226079 | Introduction
Benign prostatic hyperplasia (BPH) is the non-malignant enlargement of the prostate gland. It refers to stromal and glandular epithelial hyperplasia that occurs in the periurethral transition zone of the prostate. It clinically manifests with irritative (frequency, urgency, nocturia) and obstructive sympto... | Materials and methods
This was an analytical cross-sectional study comprising a secondary analysis of the Longitudinal Ageing Study in India (LASI) first-wave data from 35 Indian states and union territories (UTs), except Sikkim, approved by the Indian Council of Medical Research [ 11 ]. As a secondary data analysis of... | Results
A total of 27,541 study participants were included in the analysis. Their mean ± SD age (years) was calculated to be 60.06 ± 10.55 (45-59 years age group = 51.39 ± 4.27, ≥60 years age group = 68.89 ± 7.21).
Among the study population, BPH was self-reported by 410 males (1.49%), of which 144 (1.04%) were between... | Discussion
The projected increase in the population of older and elderly adults over the next few decades will be accompanied by an increase in the prevalence of chronic non-communicable diseases as well as benign prostatic hyperplasia [ 12 ]. The commonality of the risk factors behind several of these chronic diseases... | Conclusions
Self-reported BPH was found to be strongly associated with multi-morbidity, with the odds of having BPH increasing from twice as likely in individuals with at least two co-morbidities to almost six times as likely in individuals with at least four co-morbidities. The association was found to be stronger in ... | Introduction
Population ageing is expected to be accompanied by an increase in multi-morbidity, i.e. the co-occurrence of multiple chronic conditions simultaneously. Benign prostatic hyperplasia (BPH) is a non-malignant disease prevalent in ageing men. Both BPH and multi-morbidity are known to have a significant impact... | This is a secondary data analysis of the Longitudinal Ageing Study in India (LASI) wave 1, 2017–18 (https://www.iipsindia.ac.in/lasi). | CC BY | no | 2024-01-16 23:43:47 | Cureus.; 15(12):e50608 | oa_package/ff/d0/PMC10788596.tar.gz | |
PMC10788597 | 37991155 | INTRODUCTION
Grapevine ( Vitis vinifera ) has established a deep connection with human culture in its long history spanning over 5000 years (Nascimento et al., 2019 ). Nowadays, grapevine is one of the most widely distributed fruit crops all around the world and comprises many varieties for wine production, table grap... | CONCLUSION
P. viticola has become a serious threat to the viticulture globally. A comprehensive insight into the infection strategies and conditions (such as temperature and humidity), pathogenicity mechanism and plant defence response contributes to establish efficient disease management strategies against downy mi... | Abstract
Plasmopara viticola is geographically widespread in grapevine‐growing regions. Grapevine downy mildew disease, caused by this biotrophic pathogen, leads to considerable yield losses in viticulture annually. Because of the great significance of grapevine production and wine quality, research on this disease ... | INFECTION CYCLE
The life cycle of P. viticola comprises an asexual multiplication phase that occurs during the plant vegetative period and a sexual phase that ensures the survival of the pathogen over winter (Díez‐Navajas et al., 2007 ). The primary sources of inoculum in spring derive from overwintering sexual oos... | ACKNOWLEDGEMENTS
This study was supported by the Outstanding Scientist Project of Beijing Academy of Agriculture and Forestry Sciences grant JKZX202204, the Beijing Talent Program for J.Y. and the National Technology System for Grape Industry CARS‐29.
DATA AVAILABILITY STATEMENT
Data sharing is not applicable to this a... | CC BY | no | 2024-01-16 23:43:47 | Mol Plant Pathol. 2023 Nov 22; 25(1):e13401 | oa_package/4f/8b/PMC10788597.tar.gz | |||
PMC10788615 | 37721067 | Introduction
Exposure to ionising radiation can lead to adverse health effects in human beings. Therefore, accurately measuring the level of ionising radiation to which one is exposed is important. The amount of radiation received by specific individuals can be assessed through the use of biodosimetry (BD) ( 1 ) . This... | Materials and methods
The setup at HC used to irradiate blood samples consists of three major components that must be modelled: the cabinet X-ray machine, the ionisation chamber and the two water-equivalent phantoms. The source of radiation used to irradiate blood samples is an X-ray photon source, produced by the XRAD... | Results and discussion
Radiation dose output ratios between the ion chamber in the multi-slot and the single-slot phantoms were measured in the lab and simulated in EGSnrc for all three filters and represented in Figure 3 . The lab results were compared to the output of each of the simulations by taking the difference... | Results and discussion
Radiation dose output ratios between the ion chamber in the multi-slot and the single-slot phantoms were measured in the lab and simulated in EGSnrc for all three filters and represented in Figure 3 . The lab results were compared to the output of each of the simulations by taking the difference... | Conclusions
From both the lab measurements and simulations, it was found that the choice of phantom configuration does influence dose, but in all cases this effect is relatively small, especially when considering a highly attenuating filter. Using the multi-slot phantom increases the amount of dose absorbed when compar... | Abstract
When using biodosimetry techniques to assess absorbed dose from an ionising radiation exposure, a calibration curve is required. At Health Canada (HC), these curves are generated for a variety of radiation qualities and assays to translate biological damage into absorbed dose. They are produced by irradiating ... | Acknowledgements
The authors would like to knowledge all of the individuals in the Carleton Laboratory for Radiotherapy Physics (CLRP) for their assistance on the project through helpful discourse. In addition, the authors would like to thank Dr. Ernesto Mainegra-Hing for his explanations of several EGSnrc applications... | CC BY | no | 2024-01-16 23:43:48 | Radiat Prot Dosimetry. 2023 Sep 18; 199(14):1551-1556 | oa_package/38/25/PMC10788615.tar.gz | |
PMC10788616 | 38142529 | Introduction
According to 2020 global cancer statistics, prostate cancer is the second most common malignancy after lung cancer in men worldwide, over 90 % of which are prostatic adenocarcinoma [1] . Besides the urothelium of the urinary tract, urothelial carcinoma can also originate from prostatic stroma, prostatic d... | Material and methods
Study cohort
We retrospectively selected patients who were pathologically diagnosed with PUCP between January 2011 and April 2022 in the Affiliated Hospital of Qingdao University, Beijing Hospital, and Shandong Provincial Hospital Affiliated to Shandong First Medical University. Patients with a his... | Results
Clinical characteristics
The study cohort comprised 18 patients with pathological diagnoses of PUCP from January 2011 to April 2022, including seven in the Affiliated Hospital of Qingdao University, seven in Beijing Hospital, and four in Shandong Provincial Hospital Affiliated to Shandong First Medical Universi... | Discussion
Although the incidence of involvement of the prostate by urothelial carcinoma is reportedly between 12 % and 48 %, PUCP is rare [11] , [12] , [13] . Because of the low sensitivity and specificity, both underdiagnosis and misdiagnosis of PUCP is common. In our study, over half of patients had T4 tumors or ... | Conclusions
PUCP, a rare but highly aggressive type of prostate cancer, should be considered in men with abnormalities on MRI and normal serum PSA concentrations. Typical immunohistochemistry findings are positivity for GATA-3 and P63, and negativity for PSA. Radical cystectomy, chemotherapy with gemcitabine and cispla... | Objectives
To explore the features, treatment, and outcomes of primary urothelial carcinoma of the prostate (PUCP) in a multicenter study.
Methods
The clinical and imaging features, pathological findings, treatment, and outcomes of patients diagnosed with PUCP from January 2011 to April 2022 at three institutions were ... | Funding
This study was partly funded by the 10.13039/501100007129 Natural Science Foundation of Shandong Province (ZR2021MH354), Medical and health research program of Qingdao (2021-WJZD170). The funders had no roles in study design, data collection and analysis, decision to publish, or preparation of the manuscript.... | Acknowledgments
We thank Dr Trish Reynolds, MBBS, FRACP, from Liwen Bianji (Edanz) ( http://www.liwenbianji.cn/ ), for editing the English text of a draft of this manuscript. | CC BY | no | 2024-01-16 23:43:48 | Neoplasia. 2023 Dec 23; 47:100961 | oa_package/a1/71/PMC10788616.tar.gz |
PMC10788620 | 38226014 | Introduction
The tumour microenvironment (TME) provides essential cues to direct and control tumour progression and provide the basis of key hallmarks of cancer [ 1 ]. The complexity of the TME derives from both cellular and noncellular components. Cellular components are namely stromal cells including fibroblasts, imm... | Methods
Cell culture
Cell culture conditions were 37 °C, 5 % CO 2 , and 21 % O 2 . The immortalised plexiform ameloblastoma cell line, AM-1 was provided by Professor Harada [ 17 ]. Keratinocyte serum free medium 1 X (KSFM) supplemented with KSFM supplements (bovine pituitary extract (BPE) and epidermal growth factor (... | Results
The ameloblastoma transcriptome is altered in the presence of stromal cells
Tumour-stroma models were engineered using AM-1 cells as a central tumour mass. The central tumour mass was surrounded by specific stromal compartments of dense collagen I with either no cells, gingival fibroblasts (HGF) or osteoblasts ... | Discussion
Developing 3D models that recapitulate tumour-stroma interactions are essential for modelling the biomimetic tumour microenvironment in vitro . 3D tumouroid models allow compartmentalisation where different cell types can be added to distinct compartments to increase model complexity. In these complex tumou... | Stromal cells are key components of the tumour microenvironment (TME) and their incorporation into 3D engineered tumour-stroma models is essential for tumour mimicry. By engineering tumouroids with distinct tumour and stromal compartments, it has been possible to identify how gene expression of tumour cells is altered ... | Limitations
The main limitation is that the GeoMx DSP does not have the same specificity as the single cell sequencing since the platform has 1–10 cells in each spatial spot for analysis. Future steps, will include comparing the transcriptome of ameloblastoma in different locations within the tumouroids, for instance d... | Abbreviations
AM Ameloblastoma AOI Area of Illumination (AOI) APP Amyloid Precursor Protein BPE Bovine pituitary extract BMP2 Bone Morphogenic Protein 2 CK Cytokeratin COL3A1 collagen type 3 Alpha 1 Chain DMEM Dulbecco's modified Eagle medium DSP Digital Spatial Profiling DUSP6 Dual specificity phosphatase 6 (DUSP6)... | CC BY | no | 2024-01-16 23:43:48 | Mater Today Bio. 2023 Dec 21; 24:100923 | oa_package/e0/2f/PMC10788620.tar.gz | |
PMC10788621 | 38226015 | Introduction
The human body is a highly complex system composed of heterogenous tissues and organs. When the body encounters its limits in regeneration capabilities, donor tissues and organs are needed. One of the most essential senses for humans is vision. Clear vision is provided by the human cornea which is the oute... | Materials and methods
Synthesis of the crosslinking components
HA-Aldehyde (HA-ALD) was synthesized according to the previously reported protocol [ 26 ]. The synthesis of HA with dopamine and carbohydrazide modification (HA-DA-CDH) was conducted as reported previously [ 27 ]. The synthesized and lyophilized components ... | Results
Both bioinks demonstrate excellent printability and shape fidelity
The printability was assessed from grid structures. The grids were clear, and the filaments were uniform with both bioinks ( Fig. 2 (a)). The used printing pressure of the stiff bioink was 4-times higher than the pressure of the soft bioink. Aft... | Discussion
Multi-material 3D bioprinting revolutionizes medical additive manufacturing by shifting the paradigm of bioprinting from simple uni-material structures to complex, native-like tissue constructs. The heterogenous composition and organization of the corneal stroma is fundamental for the normal structure and fu... | Conclusions
Multi-material 3D bioprinting will revolutionize the field of translational additive manufacturing since uni-material bioprinting approaches cannot mimic the heterogenous nature of native human tissues. This study advances the research in additive manufacturing of human tissue constructs with heterogenous d... | Shared last authorship.
Three-dimensional (3D) bioprinting offers an automated, customizable solution to manufacture highly detailed 3D tissue constructs and holds great promise for regenerative medicine to solve the severe global shortage of donor tissues and organs. However, uni-material 3D bioprinting is not suffici... | Funding
This work was supported by grants from the 10.13039/501100004012 Jane and Aatos Erkko Foundation (HS and 10.13039/100011405 AM , 2020); 10.13039/501100002341 Academy of Finland (324082 10.13039/100011405 AM , 336666 SM, 326588 SM, 312413 SM, 337607 SM); 10.13039/501100003125 Finnish Cultural Foundation ... | Supplementary data
The following is the Supplementary data to this article.
Data availability
Data will be made available on request.
Acknowledgements
Tampere University Imaging and Histology Facilities are thanked for providing equipment and assistance for this study. In addition, the authors acknowledge the Tampere C... | CC BY | no | 2024-01-16 23:43:48 | Mater Today Bio. 2023 Dec 22; 24:100924 | oa_package/3c/30/PMC10788621.tar.gz |
PMC10788624 | 38142584 | Introduction
Urban expansion and densification and increasing needs for transportation have led to a general rise in exposure to environmental noise from vehicles, trains, and aircraft. A recent assessment of the exposure to transportation noise in the European Union, as part of the Environmental Noise Directive (END),... | Quality assessment of applied methods for detection of reactive oxygen and nitrogen species and associated oxidative damage
Redox biomarkers reported for noise exposure
The postulated key role of ROS formation for noise-induced pathophysiology is supported by a broad range of oxidative stress markers and read-outs dete... | Conclusions, redox outlook, and future perspectives
The evidence on health effects of road traffic noise has increased substantially since the evaluation conducted by a WHO appointed expert group in 2018. In contrast, although a few new studies have been published, less research progress has been observed in the railwa... | These authors contributed equally and are joint senior authors.
Transportation noise is a ubiquitous urban exposure. In 2018, the World Health Organization concluded that chronic exposure to road traffic noise is a risk factor for ischemic heart disease. In contrast, they concluded that the quality of evidence for a li... | Abbreviations
2-hydroxyethidium
4-hydroxynonenal
8-iso-prostaglandin F 2α
8-hydroxy-2’-deoxyguanosine (also 8-OH-(d)G)
adrenocorticotropic hormone
AMP-activated protein kinase
angiotensin II
tetrahydrobiopterin
brain and muscle Arnt-like protein 1
burden of disease
cardiovascular disease
confidence interval
circadian l... | Data availability
Data will be made available on request. | CC BY | no | 2024-01-16 23:43:48 | Redox Biol. 2023 Dec 18; 69:102995 | oa_package/97/04/PMC10788624.tar.gz | ||
PMC10788637 | 38221793 | Dear Editor,
Physiological lip melanosis is a disorder with a multifactorial aetiology. It varies with ethnicity and is typical of people with darker skin tones. Benign conditions (ephelides, lentigines, labial melanotic macule), malignant instances (pigmented squamous cell carcinoma, malignant melanoma), drug‐indu... | DATA AVAILABILITY STATEMENT
The data that support the findings of this study are available on request from the corresponding author. The data are not publicly available due to privacy or ethical restrictions. | CC BY | no | 2024-01-16 23:43:48 | Skin Res Technol. 2024 Jan 14; 30(1):e13581 | oa_package/c0/7f/PMC10788637.tar.gz | ||||||
PMC10788638 | 0 | INTRODUCTION
Chronic kidney disease (CKD), defined as abnormalities of kidney structure or a glomerular filtration rate (GFR) lower than 60 mL/min/1.73 m 2 for more than 3 months, poses a significant public health burden with a global prevalence of around 13.4%. 1 , 2 Despite the drastic increase in healthca... | METHODS
Study design
The research is based on the “Development of New Biosignatures for Atherosclerosis Cardiovascular Diseases” study, a multicentre cohort registry that prospectively enrolled a series of patients with the chronic coronary syndrome. This study protocol has been published previously. 22 The patien... | RESULTS
Baseline characteristics according to the FABP‐3 level
A total of 1606 patients with chronic coronary syndrome were included in this cohort study. The patients were categorized into three groups according to the baseline serum FABP‐3 levels. The patients with the highest FABP‐3 levels were the oldest ( p < .00... | DISCUSSION
Early detection of renal injury in high‐risked populations such as patients with CVD is crucial to prevent CKD or ESRD; however, reliable predictors or biomarkers are lacking. In this prospective cohort study, we investigated the relationship between FABP‐3 and the deterioration of renal function in patients... | CONCLUSIONS
We revealed a clear relationship between elevated FABP‐3 levels, inflammatory markers released after myocardial injury, and future decay of renal function in patients with chronic coronary syndrome. The results not only demonstrate that the FABP‐3 might serve as a predictor for the clinician to prevent the ... | Abstract
Background
Renal dysfunction is common in patients with coronary artery disease. Due to the shared vascular pathogenesis between the two conditions, novel biomarkers such as the fatty acid‐binding protein‐3 (FABP‐3) have been proposed for diagnosis and prognosis prediction. This multicentre prospective cohort ... | AUTHOR CONTRIBUTIONS
Jiunn‐Tyng Yeh and Chin‐Chou Huang conceived the research idea and established the study design. Chin‐Chou Huang, Hsin‐Bang Leu, Wei‐Hsian Yin, Wei‐Kung Tseng, Yen‐Wen Wu, Tsung‐Hsien Lin, Hung‐I Yeh, Kuan‐Cheng Chang, Ji‐Hung Wang, Chau‐Chung Wu, and Jaw‐Wen Chen were responsible for data acquisit... | ACKNOWLEDGMENTS
This work was supported by research grants BM10501010039 from Academia Sinica, Taiwan; V112C‐062, V111D63‐002‐MY2‐2, VGHUST112‐G7‐1‐2, V113C‐032, and V113EA‐012 from Taipei Veterans General Hospital, Taipei, Taiwan; and NSTC111‐2314‐B‐A49A‐509‐MY3 from the National Science and Technology Council, Taiwan... | CC BY | no | 2024-01-16 23:43:48 | Clin Cardiol. 2024 Jan 15; 47(1):e24210 | oa_package/17/2c/PMC10788638.tar.gz |
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