title stringlengths 3 689 | abstract stringlengths 1 512 | pmid stringlengths 5 8 | abstract embedding list | title embedding list |
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Differences in domain structure between pericellular matrix and plasma fibronectins as revealed by domain-specific antibodies combined with limited proteolysis and S-cyanylation: a preliminary note. | Differences in domain structure between human fibronectins obtained from pericellular matrix and plasma have been revealed by limited proteolysis and S-cyanylation; followed by identification of each domain with domain-specific antibodies. Although the overall domain structure is similar between pericellular and plasma... | 6360169 | [
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Differences in domain structure between pericellular matrix and plasma fibronectins as revealed by domain-specific antibodies combined with limited proteolysis and S-cyanylation: a preliminary note. | protease susceptibility; suggesting that the structure near the COOH-terminal region is significantly different between these two proteins. | 6360169 | [
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Insulin-stimulated phosphorylation of the insulin receptor precursor. | The alpha and beta subunits of the insulin receptor; Mr = 135K and 95K; appear to be synthesized via a single polypeptide precursor of Mr = 190K. We have investigated whether insulin stimulates the phosphorylation of this proreceptor; as is the case with mature receptor. Rat liver endoplasmic reticulum membranes were s... | 6360168 | [
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Insulin-stimulated phosphorylation of the insulin receptor precursor. | d an insulin-stimulated phosphoprotein of Mr = 192K; which was recognized by antireceptor antibody; compatible with the receptor precursor. This suggests that further processing of the Mr = 190K insulin receptor precursor is not necessary for insulin binding; kinase activation; and receptor phosphorylation. | 6360168 | [
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Sequence homology between prokaryotic and eukaryotic forms of serine hydroxymethyltransferase. | The sequence of tryptic and chymotryptic peptides from cytosolic and mitochondrial rabbit liver serine hydroxymethyltransferase are compared to the proposed sequence of a protein coded for by the glyA gene of Escherichia coli. The E. coli glyA gene is believed to code for serine hydroxymethyltransferase. Extensive sequ... | 6360170 | [
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Sequence homology between prokaryotic and eukaryotic forms of serine hydroxymethyltransferase. | 1. This sequence is known to contain the lysyl residue which forms a Schiff's base with pyridoxal-P in the two rabbit liver enzymes. These results support the interpretation that the proposed sequence of E. coli serine hydroxymethyltransferase is correct. The data also show that cytosolic and mitochondrial serine hydro... | 6360170 | [
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The possible involvement of prostaglandin F2 alpha in the stimulation of muscle protein synthesis by insulin. | The addition of insulin (8 ng/ml) in vitro to muscles from fasted rabbits increased protein synthesis (+80%) to a value similar to that found in muscles from fed donors. The addition of either indomethacin or meclofenamate completely blocked this effect of insulin. Muscles from fasted rabbits released less prostaglandi... | 6360171 | [
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The possible involvement of prostaglandin F2 alpha in the stimulation of muscle protein synthesis by insulin. | rease protein synthesis in muscle also stimulate PGF2 alpha release. As both arachidonic acid and PGF2 alpha in themselves increase protein synthesis we suggest that accelerated phospholipolysis and PG synthesis have a general role in the control of muscle protein turnover. | 6360171 | [
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Identification of bacteriophage T4D gene 29 product, a baseplate hub component, as a folylpolyglutamate synthetase. | An assay for folylpolyglutamate synthetase activity in extracts of uninfected and bacteriophage T4D-infected Escherichia coli B has been developed. T4D infection induced the formation of a new synthetase raising the total synthetase activity three-fold. Extracts obtained after infection with T4 gene 51; 27 or 28 amber ... | 6360172 | [
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Identification of bacteriophage T4D gene 29 product, a baseplate hub component, as a folylpolyglutamate synthetase. | ynthetase was found to copurify with the gene 29 product and a 100-fold purified synthetase of molecular size of 74;000 daltons has been obtained. The purified synthetase has a folate substrate specificity different from the host synthetase since it added glutamate residues to dihydrofolate as well as to the usual tetr... | 6360172 | [
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Yeast pheromone alpha-factor is synthesized as a high molecular weight precursor. | The sex pheromone alpha-factor of Saccharomyces cerevisiae; a tridecapeptide of approx. 1;700 molecular weight; was found to be synthesized in vivo as a high molecular weight precursor of Mr = 28;000. Inhibition of N-linked glycosylation by tunicamycin leads to three precursor species of lower molecular weight indicati... | 6360173 | [
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Essentiality of insulin and prolactin for accumulation of rat casein mRNAs. | Fetal calf serum (20%) does not substitute for insulin in terms of enhanced accumulation of rat casein mRNAs; but it can sustain the mammary tissue in culture. This property of fetal calf serum was utilized to show that in the presence of cortisol and 1) insulin or 2) prolactin; the delayed addition of prolactin or ins... | 6360174 | [
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Essentiality of insulin and prolactin for accumulation of rat casein mRNAs. | mulation is independent of the sequence of addition of these hormones; and that the response cannot be ascribed entirely to the hormone added last. | 6360174 | [
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Sites of action of Ca2+ channel inhibitors. | Ca2+ channel inhibitors are viewed as a subgroup of Ca2+ antagonists. Most of the currently used Ca2+ channel inhibitors are thought to act by reducing Ca2+ entry into the cell through Ca2+ channels. There is substantial electrophysiological evidence that the major site of action of verapamil; nifedipine and diltiazem ... | 6360175 | [
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Sites of action of Ca2+ channel inhibitors. | studies also tend to support the view that the sarcolemma is the site of action of Ca2+ channel inhibitors in smooth muscle. High affinity binding sites for 1;4-dihydropyridines without any established function are found in fast skeletal muscle and some neuronal membranes. The binding of [3H]nitrendipine to membranes ... | 6360175 | [
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Sites of action of Ca2+ channel inhibitors. | of [3H]nitrendipine binding and blockade of K+ responses in guinea pig ileum by 1;4-dihydropyridines are well correlated; supporting the view that the observed binding is to Ca2+ channel. In contrast; blockade of Ca2+ channels in cardiac and skeletal muscle and in brain synaptosomes occurs only at higher concentrations... | 6360175 | [
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Sites of action of Ca2+ channel inhibitors. | d many other disease entities is based on selective inhibition of Ca2+ entry into smooth muscle cells. The specificity of some of these drugs for Ca2+ channels in different cell types; organs; or vascular beds is probably determined by receptor modulation and the effect of reflex mechanisms; which in turn determine the... | 6360175 | [
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In vivo hydroxylation of 3H-acetanilide--evaluation of a new radiospirometric method in the rat. | The proposed in vivo methodology for the investigation of hydroxylation rates consists of of the i.v. administration of tritiated substrates and the collection of tritiated water (HTO) from exhaled air as a measure of HTO accumulation in body water. Specifically; HTO was assessed in exhaled water after i.v. administrat... | 6360176 | [
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In vivo hydroxylation of 3H-acetanilide--evaluation of a new radiospirometric method in the rat. | ated by an inverse isotope dilution method (r = 0.96; N = 18). Average T50 amounted to 29 min in controls; was reduced to 20 min after enzyme induction by phenobarbital or 3-methylcholanthrene; and prolonged to 45; 46 and 66 min after bile duct ligation; portacaval shunt and a single dose of ethanol; respectively. It i... | 6360176 | [
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In vivo hydroxylation of 3H-acetanilide--evaluation of a new radiospirometric method in the rat. | n and to liver pathology. | 6360176 | [
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Drug protein conjugates--VI. Role of glutathione in the metabolism of captopril and captopril plasma protein conjugates. | Previous metabolic studies of captopril suggest that the rapid dissociation of captopril-plasma protein conjugates in vivo is dependent upon endogenous thiols such as glutathione and cysteine. Consistent with this hypothesis; we have found that cysteine (0.06-3 mM) and glutathione (0.02-1 mM) cleave 14C-captopril-plasm... | 6360177 | [
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Drug protein conjugates--VI. Role of glutathione in the metabolism of captopril and captopril plasma protein conjugates. | ontaneous thiol-disulphide interchange. Administration of high doses (50-300 mg/kg) of CP produced a time-dependent and dose-dependent decrease in hepatic glutathione concentrations in the mouse and the rat. The depletion of glutathione observed was similar to that produced by equimolar doses of D-penicillamine and par... | 6360177 | [
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Drug protein conjugates--VI. Role of glutathione in the metabolism of captopril and captopril plasma protein conjugates. | evation of serum glutamic-pyruvic transaminase was only observed at doses of 200 and 300 mg/kg. Thus; although thiol-disulphide interactions between captopril and plasma proteins may contribute to the perturbation of hepatic glutathione concentrations; it is unlikely that this process will be of toxicological significa... | 6360177 | [
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Effect of lymphoplasmapheresis on clinical indices and T cell subsets in rheumatoid arthritis. A double-blind controlled study. | The effects of lymphoplasmapheresis on immunologic indices; including T cell subsets; and on clinical parameters of rheumatoid arthritis were evaluated in a controlled double-blind trial. Twenty patients were randomized to receive either 6 lymphoplasmapheresis sessions or a seemingly identical control procedure over a ... | 6360178 | [
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Effect of lymphoplasmapheresis on clinical indices and T cell subsets in rheumatoid arthritis. A double-blind controlled study. | eturned to baseline 5 weeks after lymphoplasmapheresis. No change in the imbalance of T cell subsets (increased helper/suppressor ratio) was observed. No changes in the serologic measures; except IgA; were observed in the control group. An improvement in some of the clinical parameters was observed in both the lymphopl... | 6360178 | [
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Interaction of polymorphonuclear leukocytes with immune complexes trapped in rheumatoid articular cartilage. | When rheumatoid articular cartilage samples were incubated with normal polymorphonuclear leukocytes (PMN) in vitro; large numbers of PMN were seen attached to the articular surface. As observed by electron microscopy; significant numbers of these cells invaded the cartilage tissue and phagocytosed amorphous material wh... | 6360179 | [
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Interaction of polymorphonuclear leukocytes with immune complexes trapped in rheumatoid articular cartilage. | PMN. These results demonstrate that immune complexes trapped in the superficial region of the rheumatoid articular cartilage may play an important role in the destruction of cartilage by the release of lysosomal enzymes from PMN. | 6360179 | [
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Sulfonyliminoimidazolidines, a new class of oral hypoglycemic agents. 3. Hypoglycemic activity and mode of action of 1-[p-[2-(crotonylamino)-ethyl]-phenylsulfonyl]-3-cyclohexyl-2-imino- imidazolidine (CGP 11 112). | 1-[p-[2-(Crotonylamino)-ethyl]-phenylsulfonyl]-3-cyclohexyl-2-imino- imidazolidine (CGP 11 112) is a representative of a new class of oral hypoglycemic agents. It lowers blood glucose in normal animals and in streptozocin (streptozotocin)-diabetic rats. In normal mice; rats and dogs the hypoglycemic effect is more pote... | 6360181 | [
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Sulfonyliminoimidazolidines, a new class of oral hypoglycemic agents. 3. Hypoglycemic activity and mode of action of 1-[p-[2-(crotonylamino)-ethyl]-phenylsulfonyl]-3-cyclohexyl-2-imino- imidazolidine (CGP 11 112). | perifused rat islets in vitro (sulfonylurea-like effect). In streptozocin-diabetic rats CGP 11 112 decreases blood glucose with a potency comparable to that of phenformin. In contrast to phenformin; CGP 11 112 does not increase blood lactate in diabetic rats or inhibit intestinal absorption of glucose. An effect of CGP... | 6360181 | [
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Sulfonyliminoimidazolidines, a new class of oral hypoglycemic agents. 3. Hypoglycemic activity and mode of action of 1-[p-[2-(crotonylamino)-ethyl]-phenylsulfonyl]-3-cyclohexyl-2-imino- imidazolidine (CGP 11 112). | x from the circulation. In vitro; CGP 11 112 inhibits glucose oxidation and lipolysis in isolated rat fat cells. | 6360181 | [
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The pathogenesis of group A streptococcal cell wall-induced polyarthritis in the rat. Comparative studies in arthritis resistant and susceptible inbred rat strains. | This report addresses the host mechanisms which regulate susceptibility and resistance to group A streptococcal cell wall-induced polyarthritis in the rat. We have compared cell wall tissue distribution and persistence following a single intraperitoneal injection of an aqueous suspension of the cell walls into arthriti... | 6360180 | [
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The pathogenesis of group A streptococcal cell wall-induced polyarthritis in the rat. Comparative studies in arthritis resistant and susceptible inbred rat strains. | ritis in this model is dependent; in variable degrees; upon 1) deposition and persistence of the cell walls in synovial tissues; and 2) a relative inability of arthritis susceptible rats to neutralize the proinflammatory properties of the cell walls. | 6360180 | [
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Ethical Practice Board statement of practices and procedures (effective September 1982). | nan | 6360183 | [
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William W. Green. | nan | 6360182 | [
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A consultation model for speech and language intervention. | nan | 6360184 | [
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Renal rehabilitation: a state of the art review. | nan | 6360185 | [
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Occupational therapy in the rehabilitation of nephrology patients. | nan | 6360187 | [
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The use of rehabilitation services by patients with chronic renal failure: results from the National Kidney Dialysis and Kidney Transplantation Study. | nan | 6360186 | [
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[Biomedical research at the Hospital Infantil de México]. | nan | 6360188 | [
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Influence of external and covert food stimuli on insulin secretion in obese and normal persons. | Exposure to food produces an increase in insulin secretion that is more pronounced in obese than in normal persons. We sought to replicate this finding as well as to determine whether insulin secretion could be influenced by thoughts about food and eating. Normal and obese subjects were presented in counterbalanced ord... | 6360189 | [
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Influence of external and covert food stimuli on insulin secretion in obese and normal persons. | us presentation. All subjects displayed higher insulin levels following stimulus presentation; with the values for the obese higher than for normals. Although the insulin secretion of the obese was greater in response to the covert as opposed to the external stimulus; the difference was not significant. Salivary output... | 6360189 | [
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Influence of external and covert food stimuli on insulin secretion in obese and normal persons. | chanism. | 6360189 | [
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The teeth and infective endocarditis. | During 1981 and 1982 544 cases of infective endocarditis were investigated retrospectively by means of a questionnaire. Only 13.7% had undergone any dental procedure within three months of the onset of the illness; and in 42.5% there was no known cardiac abnormality before the onset of the disease. Furthermore; the num... | 6360190 | [
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The teeth and infective endocarditis. | m; Streptococcus viridans; and it is suggested that it is not dental extractions themselves which are of importance but good dental hygiene. In most patients with infective endocarditis the portal of entry of the organism whatever its nature cannot be identified. If this is so antibiotics are being given to only a smal... | 6360190 | [
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The teeth and infective endocarditis. | th no known previous cardiac abnormality adds to the difficulty of providing effective prophylaxis. The evidence suggests that antibiotic prophylaxis should still be given before dental procedures; and a schedule is appended. Much more importance should be given; however; to encouraging people to seek better routine de... | 6360190 | [
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The teeth and infective endocarditis. | s a revised approach to the problem. | 6360190 | [
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Electrophysiological abnormalities in the transplanted human heart. | Fourteen relatively long term survivors of cardiac transplantation underwent systematic electrophysiological evaluation and ambulatory electrocardiographic monitoring. Six patients had prolonged conduction intervals during sinus rhythm. Sinus node function could be assessed in all donor atria and in 10 recipient atria.... | 6360191 | [
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Electrophysiological abnormalities in the transplanted human heart. | ormalities of sinoatrial conduction. Four patients showed functional duality of atrioventricular nodal conduction during programmed extrastimulation; but no patient developed re-entrant arrhythmia. During ambulatory electrocardiographic monitoring no pronounced tachyarrhythmias were recorded. Three patients showed abno... | 6360191 | [
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Electrophysiological abnormalities in the transplanted human heart. | e a high incidence of electrophysiological abnormalities. Abnormalities of donor sinus node function are probably of clinical significance. The clinical significance of abnormalities detected within the atrioventricular conduction system of the denervated heart remains to be elucidated. | 6360191 | [
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Routine immunofluorescent and histochemical analysis of bone marrow involvement of lymphoma/leukaemia: the use of cryostat sections. | Enzyme histochemical and immunohistological (immuno-fluorescence and -peroxidase) techniques have been routinely used for investigating over 70 normal and pathological bone marrow samples. This recently standardized diagnostic procedure is very quick and can be performed in a few hours. In 6 cases the clinical diagnosi... | 6360192 | [
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Routine immunofluorescent and histochemical analysis of bone marrow involvement of lymphoma/leukaemia: the use of cryostat sections. | r in the frozen biopsies to the paraffin embedded preparations. Amongst many other features the monoclonality of B CLL/lymphomas; the special features of B CLL infiltrates (RFA-1+; Leu-1+; HLA-DR+; SmIg+); follicular lymphoma deposits (containing follicular dendritic cells) and non-T; non-B acute lymphoblastic leukaemi... | 6360192 | [
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Sister chromatid exchange in lymphocytes from renal transplant recipients with and without cancer. | The frequency of sister chromatid exchange (SCE) was measured in peripheral blood lymphocytes from control; healthy subjects and immunosuppressed recipients of cadaveric donor kidneys with and without skin cancer. The mean SCE frequency in 43 control subjects was 9.2 per cell (range 5.4-12.3). In 30 transplant recipien... | 6360193 | [
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Sister chromatid exchange in lymphocytes from renal transplant recipients with and without cancer. | recipients with skin cancer; the mean SCE frequency was 14.3 per cell (range 9.1-19.9). This was significantly (P less than 0.01) higher than the mean value of control subjects. The mean SCE frequencies in 3 of these 7 patients fell within the control range and in 4 of these patients was above the control range. These ... | 6360193 | [
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Potential biological explanation of stimulation of colony growth in semi-solid agar by cytotoxic agents. | nan | 6360194 | [
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0.005535... |
Distribution of major histocompatibility antigens in normal skin. | The distribution of major histocompatibility antigens HLA-A;B;C (HLA); beta 2-microglobulin (beta 2m); and Ia-like antigens (HLA-DR; Ia) in normal skin was studied in frozen tissue sections by a four-step immunoperoxidase method and an avidin-biotin method employing monoclonal antibodies. HLA and beta 2m were present o... | 6360195 | [
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Distribution of major histocompatibility antigens in normal skin. | e dendritic cells were found in the epidermis and hair follicles; but they were more frequent in the infundibulum and isthmus of the hair follicle than in its inferior portion or in the epidermis. In the straight eccrine duct; HLA and beta 2m-positivity was most striking in its lower portion. In the superficial duct; t... | 6360195 | [
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0.007218... |
Distribution of major histocompatibility antigens in normal skin. | dly Ia-positive with decreasing intensity of staining as the duct penetrated the dermis. No HLA or Ia antigens were identified in eccrine glands and apocrine glands. Eccrine glands were slightly beta 2m-positive. HLA and beta 2m were uniformly present in non-dilated and dilated intradermal apocrine ducts. | 6360195 | [
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-0.0... |
Professor Emeritus George Hector Percival. | nan | 6360196 | [
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0.006385553,
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0.009551273,
0.02006308... |
Positive immunofluorescence in bullous lesions in drug-induced coma. | nan | 6360197 | [
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0.018726457,
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-0.0027536948,
-0.015090... |
The risks of antenatal subcutaneous heparin prophylaxis: a controlled trial. | The risks of long-term antenatal subcutaneous heparin therapy were assessed in a small controlled trial of prophylaxis of thromboembolism. Forty patients with a documented history of previous thromboembolism were randomly allocated either to receive heparin (10000 i.u. subcutaneously twice daily) throughout pregnancy a... | 6360198 | [
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0.0050787553,
-0.027593238,
-0.06968959,
0.035138056,
0.032... |
The risks of antenatal subcutaneous heparin prophylaxis: a controlled trial. | be no increased risk of antenatal or postnatal bleeding associated with subcutaneous heparin; but one patient in the control group developed a deep vein thrombosis and one in the treatment group developed severe debilitating osteopenia. The withholding of epidural analgesia may have contributed to both maternal and fet... | 6360198 | [
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0.0842... | [
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0.032109972,
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0.03393868,
0.084... |
The risks of antenatal subcutaneous heparin prophylaxis: a controlled trial. | Although the numbers are too small for statistical analysis; the findings indicate that the use of long-term low-dose subcutaneous heparin is not without complications and there is need for a larger; multicentre trial to allow precise quantification of fetal and maternal risks against the risk of recurrent thromboembol... | 6360198 | [
-0.053731836,
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0.0254... | [
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0.01710977,
0.02553119... |
Reliability of cytological follow-up after conization of the cervix; a comparison of three surgical techniques. | A retrospective analysis was made of 154 consecutive conizations between 1974 and 1982. Three surgical methods were compared: (A) Sturmdorf sutures; (B) interrupted vertical sutures; and (C) an 'open' method using only cauterization and no additional stitches. The mean blood loss during conization was not reduced by li... | 6360199 | [
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0.0174201... | [
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0.031451922,
0.0173... |
Reliability of cytological follow-up after conization of the cervix; a comparison of three surgical techniques. | ous epithelium or too little material to allow diagnosis were considered inadequate. Unreliable follow-up was defined as inadequacy of more than 25% of a patient's smears. Thirty per cent of all follow-up smears were inadequate (group A 33%; B 41%; C 16%). In 46% of the patients; cytological follow-up was unreliable (g... | 6360199 | [
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0.03344428,
0.012264... |
Reliability of cytological follow-up after conization of the cervix; a comparison of three surgical techniques. | ups were statistically significant (P less than 0.01; chi 2 test). | 6360199 | [
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0.03042841,
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0.034... |
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