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0 | PMID-10085159 | [
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1 | PMID-10224130 | [
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2 | PMID-10329026 | [
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3 | PMID-10346818 | [
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4 | PMID-10364168 | [
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5 | PMID-10369669 | [
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6 | PMID-10373560 | [
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7 | PMID-10383454 | [
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8 | PMID-10385526 | [
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... | [] |
9 | PMID-10389141 | [
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10 | PMID-10391247 | [
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11 | PMID-10421629 | [
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12 | PMID-10455013 | [
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13 | PMID-10487762 | [
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14 | PMID-10508167 | [
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15 | PMID-10508788 | [
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16 | PMID-10517323 | [
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17 | PMID-10523842 | [
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]
},
"arguments": [
{
"role": "Theme",
"ref_id": "PMID-10523842_T1"
}
]
},
... | [] | [] |
18 | PMID-10542212 | [
{
"id": "PMID-10542212__text",
"type": "abstract",
"text": [
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{
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0,
14
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],
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},
{
"id": "PMID-10542212_T2",
"type": "Complex",
"text": [
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],
... | [
{
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"type": "Pathway",
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"text": [
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],
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15,
24
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]
},
"arguments": [
{
"role": "Participant",
"ref_id": "PMID-10542212_T1"
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{
... | [
{
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},
{
"id": "PMID-10542212_3",
"entity_ids": [
"PMID-10542212_T13",
... | [] |
19 | PMID-10556521 | [
{
"id": "PMID-10556521__text",
"type": "abstract",
"text": [
"Cloning and functional characterization of the human sodium-dependent vitamin C transporters hSVCT1 and hSVCT2. \nTwo sodium-dependent vitamin C transporters, hSVCT1 and hSVCT2, were cloned from a human kidney cDNA library. hSVCT1 had a... | [
{
"id": "PMID-10556521_T1",
"type": "Simple_chemical",
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],
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53,
59
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{
"id": "PMID-10556521_T2",
"type": "Simple_chemical",
"text": [
"vitamin C"
],
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[... | [
{
"id": "PMID-10556521_E1",
"type": "Positive_regulation",
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"text": [
"dependent"
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60,
69
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]
},
"arguments": [
{
"role": "Cause",
"ref_id": "PMID-10556521_T1"
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{
... | [
{
"id": "PMID-10556521_1",
"entity_ids": [
"PMID-10556521_T17",
"PMID-10556521_T18"
]
}
] | [] |
20 | PMID-10567559 | [
{
"id": "PMID-10567559__text",
"type": "abstract",
"text": [
"PDK1 homologs activate the Pkc1-mitogen-activated protein kinase pathway in yeast. \nPDK1 (phosphoinositide-dependent kinase 1) is a mammalian growth factor-regulated serine/threonine kinase. Using a genetic selection based on a mutant ... | [
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"id": "PMID-10567559_T1",
"type": "Gene_or_gene_product",
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0,
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},
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"id": "PMID-10567559_T2",
"type": "Gene_or_gene_product",
"text": [
"Pkc1"
],
"offsets": [
... | [
{
"id": "PMID-10567559_E1",
"type": "Positive_regulation",
"trigger": {
"text": [
"activate"
],
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14,
22
]
]
},
"arguments": [
{
"role": "Cause",
"ref_id": "PMID-10567559_T1"
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{
... | [
{
"id": "PMID-10567559_1",
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"PMID-10567559_T5"
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},
{
"id": "PMID-10567559_2",
"entity_ids": [
"PMID-10567559_T20",
"PMID-10567559_T21"
]
}
] | [] |
21 | PMID-10574991 | [
{
"id": "PMID-10574991__text",
"type": "abstract",
"text": [
"Pig-n, a mammalian homologue of yeast Mcd4p, is involved in transferring phosphoethanolamine to the first mannose of the glycosylphosphatidylinositol. \nMany cell surface proteins are anchored to the membrane via a glycosylphosphatidyli... | [
{
"id": "PMID-10574991_T1",
"type": "Gene_or_gene_product",
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0,
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],
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"id": "PMID-10574991_T2",
"type": "Gene_or_gene_product",
"text": [
"Mcd4p"
],
"offsets": [
... | [
{
"id": "PMID-10574991_E1",
"type": "Regulation",
"trigger": {
"text": [
"involved"
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48,
56
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]
},
"arguments": [
{
"role": "Cause",
"ref_id": "PMID-10574991_T1"
},
{
"r... | [
{
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{
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]
},
{
"id": "PMID-10574991_3",
"entity_ids": [
"PMID-10574991_T27",
... | [] |
22 | PMID-10608887 | [
{
"id": "PMID-10608887__text",
"type": "abstract",
"text": [
"Heparan sulfate D-glucosaminyl 3-O-sulfotransferase-3A sulfates N-unsubstituted glucosamine residues. \n3-O-Sulfation of glucosamine by heparan sulfate D-glucosaminyl 3-O-sulfotransferase (3-OST-1) is the key modification in anticoagula... | [
{
"id": "PMID-10608887_T1",
"type": "Gene_or_gene_product",
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},
{
"id": "PMID-10608887_T2",
"type": "Simple_chemical",
"text":... | [
{
"id": "PMID-10608887_E1",
"type": "Conversion",
"trigger": {
"text": [
"sulfates"
],
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55,
63
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]
},
"arguments": [
{
"role": "Theme",
"ref_id": "PMID-10608887_T2"
}
]
},
{
... | [
{
"id": "PMID-10608887_1",
"entity_ids": [
"PMID-10608887_T4",
"PMID-10608887_T5"
]
}
] | [] |
23 | PMID-10639137 | [
{
"id": "PMID-10639137__text",
"type": "abstract",
"text": [
"The putative tumor suppressors EXT1 and EXT2 form a stable complex that accumulates in the Golgi apparatus and catalyzes the synthesis of heparan sulfate. \nHereditary multiple exostoses, a dominantly inherited genetic disorder characte... | [
{
"id": "PMID-10639137_T1",
"type": "Gene_or_gene_product",
"text": [
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31,
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],
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},
{
"id": "PMID-10639137_T2",
"type": "Gene_or_gene_product",
"text": [
"EXT2"
],
"offsets": [
... | [
{
"id": "PMID-10639137_E1",
"type": "Binding",
"trigger": {
"text": [
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],
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[
45,
66
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]
},
"arguments": [
{
"role": "Theme",
"ref_id": "PMID-10639137_T1"
},
{
... | [] | [] |
24 | PMID-10642555 | [
{
"id": "PMID-10642555__text",
"type": "abstract",
"text": [
"Rad6-dependent ubiquitination of histone H2B in yeast. \nAlthough ubiquitinated histones are present in substantial levels in vertebrate cells, the roles they play in specific biological processes and the cellular factors that regulate ... | [
{
"id": "PMID-10642555_T1",
"type": "Gene_or_gene_product",
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[
0,
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],
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},
{
"id": "PMID-10642555_T2",
"type": "Gene_or_gene_product",
"text": [
"histone H2B"
],
"offsets": [... | [
{
"id": "PMID-10642555_E1",
"type": "Positive_regulation",
"trigger": {
"text": [
"dependent"
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[
5,
14
]
]
},
"arguments": [
{
"role": "Theme",
"ref_id": "PMID-10642555_E2"
},
{
... | [
{
"id": "PMID-10642555_1",
"entity_ids": [
"PMID-10642555_T4",
"PMID-10642555_T5"
]
}
] | [] |
25 | PMID-10655592 | [
{
"id": "PMID-10655592__text",
"type": "abstract",
"text": [
"Nuclear sequestration of the exchange factor Cdc24 by Far1 regulates cell polarity during yeast mating. \nCytoskeletal rearrangements during the cell cycle and in response to signals are regulated by small Rho-type GTPases, but it is no... | [
{
"id": "PMID-10655592_T1",
"type": "Cellular_component",
"text": [
"Nuclear"
],
"offsets": [
[
0,
7
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],
"normalized": []
},
{
"id": "PMID-10655592_T2",
"type": "Gene_or_gene_product",
"text": [
"Cdc24"
],
"offsets": [
... | [
{
"id": "PMID-10655592_E1",
"type": "Transport",
"trigger": {
"text": [
"sequestration"
],
"offsets": [
[
8,
21
]
]
},
"arguments": [
{
"role": "ToLoc",
"ref_id": "PMID-10655592_T1"
},
{
... | [] | [] |
26 | PMID-10748143 | [
{
"id": "PMID-10748143__text",
"type": "abstract",
"text": [
"Molecular cloning of globotriaosylceramide/CD77 synthase, a glycosyltransferase that initiates the synthesis of globo series glycosphingolipids. \nThe expression cloning of a cDNA for globotriaosylceramide (Gb3)/CD77 synthase (alpha1,4-... | [
{
"id": "PMID-10748143_T1",
"type": "Gene_or_gene_product",
"text": [
"globotriaosylceramide/CD77 synthase"
],
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[
21,
56
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],
"normalized": []
},
{
"id": "PMID-10748143_T2",
"type": "Simple_chemical",
"text": [
"glycosph... | [
{
"id": "PMID-10748143_E1",
"type": "Positive_regulation",
"trigger": {
"text": [
"initiates"
],
"offsets": [
[
85,
94
]
]
},
"arguments": [
{
"role": "Cause",
"ref_id": "PMID-10748143_T1"
},
{
... | [
{
"id": "PMID-10748143_1",
"entity_ids": [
"PMID-10748143_T3",
"PMID-10748143_T4"
]
},
{
"id": "PMID-10748143_2",
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"PMID-10748143_T11"
]
},
{
"id": "PMID-10748143_3",
"entity_ids": [
"PMID-10748143_T15",
... | [] |
27 | PMID-10753885 | [
{
"id": "PMID-10753885__text",
"type": "abstract",
"text": [
"E2F family members are differentially regulated by reversible acetylation. \nThe six members of the E2F family of transcription factors play a key role in the control of cell cycle progression by regulating the expression of genes invol... | [
{
"id": "PMID-10753885_T1",
"type": "Gene_or_gene_product",
"text": [
"E2F"
],
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[
0,
3
]
],
"normalized": []
},
{
"id": "PMID-10753885_T2",
"type": "Gene_or_gene_product",
"text": [
"E2F"
],
"offsets": [
[
... | [
{
"id": "PMID-10753885_E1",
"type": "Regulation",
"trigger": {
"text": [
"regulated"
],
"offsets": [
[
38,
47
]
]
},
"arguments": [
{
"role": "Theme",
"ref_id": "PMID-10753885_T1"
}
]
},
{
... | [] | [] |
28 | PMID-10777476 | [
{
"id": "PMID-10777476__text",
"type": "abstract",
"text": [
"Mechanism of reaction of myeloperoxidase with nitrite. \nMyeloperoxidase (MPO) is a major neutrophil protein and may be involved in the nitration of tyrosine residues observed in a wide range of inflammatory diseases that involve neutro... | [
{
"id": "PMID-10777476_T1",
"type": "Gene_or_gene_product",
"text": [
"myeloperoxidase"
],
"offsets": [
[
25,
40
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],
"normalized": []
},
{
"id": "PMID-10777476_T2",
"type": "Simple_chemical",
"text": [
"nitrite"
],
"offsets... | [
{
"id": "PMID-10777476_E1",
"type": "Binding",
"trigger": {
"text": [
"formation"
],
"offsets": [
[
607,
616
]
]
},
"arguments": [
{
"role": "Theme",
"ref_id": "PMID-10777476_T11"
},
{
"... | [
{
"id": "PMID-10777476_1",
"entity_ids": [
"PMID-10777476_T3",
"PMID-10777476_T4"
]
}
] | [] |
29 | PMID-10811867 | [
{
"id": "PMID-10811867__text",
"type": "abstract",
"text": [
"Bruton's tyrosine kinase is required for activation of IkappaB kinase and nuclear factor kappaB in response to B cell receptor engagement. \nMutations in the gene encoding Bruton's tyrosine kinase (btk) cause the B cell deficiency disea... | [
{
"id": "PMID-10811867_T1",
"type": "Gene_or_gene_product",
"text": [
"Bruton's tyrosine kinase"
],
"offsets": [
[
0,
24
]
],
"normalized": []
},
{
"id": "PMID-10811867_T2",
"type": "Complex",
"text": [
"IkappaB kinase"
],
"... | [
{
"id": "PMID-10811867_E1",
"type": "Positive_regulation",
"trigger": {
"text": [
"required"
],
"offsets": [
[
28,
36
]
]
},
"arguments": [
{
"role": "Cause",
"ref_id": "PMID-10811867_T1"
},
{
... | [
{
"id": "PMID-10811867_1",
"entity_ids": [
"PMID-10811867_T4",
"PMID-10811867_T5"
]
},
{
"id": "PMID-10811867_2",
"entity_ids": [
"PMID-10811867_T7",
"PMID-10811867_T8"
]
},
{
"id": "PMID-10811867_3",
"entity_ids": [
"PMID-10811867_T16",
"P... | [] |
30 | PMID-10837071 | [
{
"id": "PMID-10837071__text",
"type": "abstract",
"text": [
"Phosphorylation meets ubiquitination: the control of NF-[kappa]B activity. \nNF-kappaB (nuclear factor-kappaB) is a collective name for inducible dimeric transcription factors composed of members of the Rel family of DNA-binding protein... | [
{
"id": "PMID-10837071_T1",
"type": "Complex",
"text": [
"NF-[kappa]B"
],
"offsets": [
[
53,
64
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],
"normalized": []
},
{
"id": "PMID-10837071_T2",
"type": "Complex",
"text": [
"NF-kappaB"
],
"offsets": [
[
76... | [
{
"id": "PMID-10837071_E1",
"type": "Localization",
"trigger": {
"text": [
"sequestered"
],
"offsets": [
[
542,
553
]
]
},
"arguments": [
{
"role": "Theme",
"ref_id": "PMID-10837071_T6"
},
{
... | [
{
"id": "PMID-10837071_1",
"entity_ids": [
"PMID-10837071_T2",
"PMID-10837071_T3"
]
},
{
"id": "PMID-10837071_2",
"entity_ids": [
"PMID-10837071_T22",
"PMID-10837071_T23"
]
}
] | [] |
31 | PMID-10873608 | [
{
"id": "PMID-10873608__text",
"type": "abstract",
"text": [
"p63 and p73 transactivate differentiation gene promoters in human keratinocytes. \np53 and its two homologues, p73 and p63, share considerable structural similarities, an ability to interact between themselves and to transactivate the s... | [
{
"id": "PMID-10873608_T1",
"type": "Gene_or_gene_product",
"text": [
"p63"
],
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[
0,
3
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],
"normalized": []
},
{
"id": "PMID-10873608_T2",
"type": "Gene_or_gene_product",
"text": [
"p73"
],
"offsets": [
[
... | [
{
"id": "PMID-10873608_E1",
"type": "Binding",
"trigger": {
"text": [
"interact"
],
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[
181,
189
]
]
},
"arguments": [
{
"role": "Theme",
"ref_id": "PMID-10873608_T3"
},
{
"ro... | [] | [] |
32 | PMID-10899305 | [
{
"id": "PMID-10899305__text",
"type": "abstract",
"text": [
"Translocation of Akt/PKB to the nucleus of osteoblast-like MC3T3-E1 cells exposed to proliferative growth factors. \nAn active phosphatidylinositol 3-kinase (PI3K) has been shown in nuclei of different cell types. The products of this e... | [
{
"id": "PMID-10899305_T1",
"type": "Gene_or_gene_product",
"text": [
"Akt"
],
"offsets": [
[
17,
20
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],
"normalized": []
},
{
"id": "PMID-10899305_T2",
"type": "Gene_or_gene_product",
"text": [
"PKB"
],
"offsets": [
... | [
{
"id": "PMID-10899305_E1",
"type": "Transport",
"trigger": {
"text": [
"Translocation"
],
"offsets": [
[
0,
13
]
]
},
"arguments": [
{
"role": "Theme",
"ref_id": "PMID-10899305_T1"
},
{
... | [
{
"id": "PMID-10899305_1",
"entity_ids": [
"PMID-10899305_T1",
"PMID-10899305_T2"
]
},
{
"id": "PMID-10899305_2",
"entity_ids": [
"PMID-10899305_T4",
"PMID-10899305_T5"
]
},
{
"id": "PMID-10899305_3",
"entity_ids": [
"PMID-10899305_T13",
"P... | [] |
33 | PMID-10915796 | [
{
"id": "PMID-10915796__text",
"type": "abstract",
"text": [
"Characterization of a cDNA encoding a novel human Golgi alpha 1, 2-mannosidase (IC) involved in N-glycan biosynthesis. \nA human cDNA encoding a 70.9-kDa type II membrane protein with sequence similarity to class I alpha1,2-mannosidases... | [
{
"id": "PMID-10915796_T1",
"type": "Cellular_component",
"text": [
"Golgi"
],
"offsets": [
[
50,
55
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],
"normalized": []
},
{
"id": "PMID-10915796_T2",
"type": "Gene_or_gene_product",
"text": [
"alpha 1, 2-mannosidase"
],
... | [
{
"id": "PMID-10915796_E1",
"type": "Positive_regulation",
"trigger": {
"text": [
"involved"
],
"offsets": [
[
84,
92
]
]
},
"arguments": [
{
"role": "Theme",
"ref_id": "PMID-10915796_E2"
},
{
... | [] | [] |
34 | PMID-10918611 | [
{
"id": "PMID-10918611__text",
"type": "abstract",
"text": [
"SCF(beta-TRCP) and phosphorylation dependent ubiquitinationof I kappa B alpha catalyzed by Ubc3 and Ubc4. \nNF kappa B is an important transcriptional regulator of multiple pro-inflammatory genes. In non-stimulated cells NF kappa B is a... | [
{
"id": "PMID-10918611_T1",
"type": "Complex",
"text": [
"SCF(beta-TRCP)"
],
"offsets": [
[
0,
14
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],
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},
{
"id": "PMID-10918611_T2",
"type": "Gene_or_gene_product",
"text": [
"I kappa B alpha"
],
"offsets":... | [
{
"id": "PMID-10918611_E1",
"type": "Phosphorylation",
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"text": [
"phosphorylation"
],
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19,
34
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]
},
"arguments": [
{
"role": "Theme",
"ref_id": "PMID-10918611_T2"
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]
... | [
{
"id": "PMID-10918611_1",
"entity_ids": [
"PMID-10918611_T12",
"PMID-10918611_T13"
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}
] | [] |
35 | PMID-10975521 | [
{
"id": "PMID-10975521__text",
"type": "abstract",
"text": [
"Regulation of transcription by ubiquitination without proteolysis: Cdc34/SCF(Met30)-mediated inactivation of the transcription factor Met4. \nPolyubiquitination of proteins by Cdc34/SCF complexes targets them for degradation by the 26S ... | [
{
"id": "PMID-10975521_T1",
"type": "Complex",
"text": [
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],
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67,
83
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},
{
"id": "PMID-10975521_T2",
"type": "Gene_or_gene_product",
"text": [
"Met4"
],
"offsets": [
... | [
{
"id": "PMID-10975521_E1",
"type": "Positive_regulation",
"trigger": {
"text": [
"mediated"
],
"offsets": [
[
84,
92
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]
},
"arguments": [
{
"role": "Cause",
"ref_id": "PMID-10975521_T1"
},
{
... | [] | [] |
36 | PMID-11101520 | [
{
"id": "PMID-11101520__text",
"type": "abstract",
"text": [
"Nud1p links astral microtubule organization and the control of exit from mitosis. \nThe budding yeast spindle pole body (SPB) not only organizes the astral and nuclear microtubules but is also associated with a number of cell-cycle regu... | [
{
"id": "PMID-11101520_T1",
"type": "Gene_or_gene_product",
"text": [
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],
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[
0,
5
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],
"normalized": []
},
{
"id": "PMID-11101520_T2",
"type": "Cellular_component",
"text": [
"astral microtubule"
],
"offse... | [
{
"id": "PMID-11101520_E1",
"type": "Pathway",
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"text": [
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],
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220,
230
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]
},
"arguments": []
},
{
"id": "PMID-11101520_E2",
"type": "Positive_regulation",
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... | [
{
"id": "PMID-11101520_1",
"entity_ids": [
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"PMID-11101520_T4"
]
}
] | [] |
37 | PMID-11101877 | [
{
"id": "PMID-11101877__text",
"type": "abstract",
"text": [
"Toll-like receptor 2-mediated NF-kappa B activation requires a Rac1-dependent pathway. \nMammalian Toll-like receptors (TLRs) are expressed on innate immune cells and respond to the membrane components of Gram-positive or Gram-negative ... | [
{
"id": "PMID-11101877_T1",
"type": "Gene_or_gene_product",
"text": [
"Toll-like receptor 2"
],
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[
0,
20
]
],
"normalized": []
},
{
"id": "PMID-11101877_T2",
"type": "Complex",
"text": [
"NF-kappa B"
],
"offsets"... | [
{
"id": "PMID-11101877_E1",
"type": "Positive_regulation",
"trigger": {
"text": [
"mediated"
],
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[
21,
29
]
]
},
"arguments": [
{
"role": "Cause",
"ref_id": "PMID-11101877_T1"
},
{
... | [
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},
{
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"PMID-11101877_T17"
]
},
{
"id": "PMID-11101877_3",
"entity_ids": [
"PMID-11101877_T19",
... | [] |
38 | PMID-11139340 | [
{
"id": "PMID-11139340__text",
"type": "abstract",
"text": [
"p53-independent upregulation of KILLER/DR5 TRAIL receptor expression by glucocorticoids and interferon-gamma. \nKILLER/DR5 is a death-domain-containing proapoptotic receptor that binds to the cytotoxic ligand TRAIL. It was originally re... | [
{
"id": "PMID-11139340_T1",
"type": "Gene_or_gene_product",
"text": [
"p53"
],
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[
0,
3
]
],
"normalized": []
},
{
"id": "PMID-11139340_T2",
"type": "Gene_or_gene_product",
"text": [
"KILLER"
],
"offsets": [
... | [
{
"id": "PMID-11139340_E1",
"type": "Regulation",
"trigger": {
"text": [
"independent"
],
"offsets": [
[
4,
15
]
]
},
"arguments": [
{
"role": "Cause",
"ref_id": "PMID-11139340_T1"
},
{
... | [
{
"id": "PMID-11139340_1",
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"PMID-11139340_T2",
"PMID-11139340_T3"
]
},
{
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"PMID-11139340_T8"
]
},
{
"id": "PMID-11139340_3",
"entity_ids": [
"PMID-11139340_T11",
"P... | [] |
39 | PMID-11171059 | [
{
"id": "PMID-11171059__text",
"type": "abstract",
"text": [
"Phosphorylation of elongation factor-2 kinase on serine 499 by cAMP-dependent protein kinase induces Ca2+/calmodulin-independent activity. \nElongation factor-2 kinase (eEF-2K) negatively regulates mRNA translation via the phosphorylati... | [
{
"id": "PMID-11171059_T1",
"type": "Gene_or_gene_product",
"text": [
"elongation factor-2 kinase"
],
"offsets": [
[
19,
45
]
],
"normalized": []
},
{
"id": "PMID-11171059_T2",
"type": "Simple_chemical",
"text": [
"serine 499"
]... | [
{
"id": "PMID-11171059_E1",
"type": "Phosphorylation",
"trigger": {
"text": [
"Phosphorylation"
],
"offsets": [
[
0,
15
]
]
},
"arguments": [
{
"role": "Site",
"ref_id": "PMID-11171059_T2"
},
{
... | [
{
"id": "PMID-11171059_1",
"entity_ids": [
"PMID-11171059_T6",
"PMID-11171059_T7"
]
},
{
"id": "PMID-11171059_2",
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]
},
{
"id": "PMID-11171059_3",
"entity_ids": [
"PMID-11171059_T11",
"P... | [] |
40 | PMID-11278681 | [
{
"id": "PMID-11278681__text",
"type": "abstract",
"text": [
"Yeast Mps1p phosphorylates the spindle pole component Spc110p in the N-terminal domain. \nThe yeast spindle pole body (SPB) component Spc110p (Nuf1p) undergoes specific serine/threonine phosphorylation as the mitotic spindle apparatus f... | [
{
"id": "PMID-11278681_T1",
"type": "Gene_or_gene_product",
"text": [
"Mps1p"
],
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[
6,
11
]
],
"normalized": []
},
{
"id": "PMID-11278681_T2",
"type": "Cellular_component",
"text": [
"spindle pole"
],
"offsets": ... | [
{
"id": "PMID-11278681_E1",
"type": "Phosphorylation",
"trigger": {
"text": [
"phosphorylates"
],
"offsets": [
[
12,
26
]
]
},
"arguments": [
{
"role": "Cause",
"ref_id": "PMID-11278681_T1"
},
{... | [
{
"id": "PMID-11278681_1",
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"PMID-11278681_T4",
"PMID-11278681_T5"
]
},
{
"id": "PMID-11278681_2",
"entity_ids": [
"PMID-11278681_T6",
"PMID-11278681_T7"
]
}
] | [] |
41 | PMID-11313932 | [
{
"id": "PMID-11313932__text",
"type": "abstract",
"text": [
"Localization of human Cdc25C is regulated both by nuclear export and 14-3-3 protein binding. \nEntry into mitosis requires activation of the Cdc2 protein kinase by the Cdc25C protein phosphatase. The interactions between Cdc2 and Cdc25C... | [
{
"id": "PMID-11313932_T1",
"type": "Gene_or_gene_product",
"text": [
"Cdc25C"
],
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[
22,
28
]
],
"normalized": []
},
{
"id": "PMID-11313932_T2",
"type": "Cellular_component",
"text": [
"nuclear"
],
"offsets": [
... | [
{
"id": "PMID-11313932_E1",
"type": "Localization",
"trigger": {
"text": [
"Localization"
],
"offsets": [
[
0,
12
]
]
},
"arguments": [
{
"role": "Theme",
"ref_id": "PMID-11313932_T1"
}
]
},
{... | [
{
"id": "PMID-11313932_1",
"entity_ids": [
"PMID-11313932_T16",
"PMID-11313932_T17"
]
}
] | [] |
42 | PMID-11313986 | [
{
"id": "PMID-11313986__text",
"type": "abstract",
"text": [
"Regulation of the Cdc25A gene by the human papillomavirus Type 16 E7 oncogene. \nCdc25A is a tyrosine phosphatase that is involved in the regulation of the G1/S phase transition by activating cyclin E/Cdk2 and cyclin A/Cdk2 complexes th... | [
{
"id": "PMID-11313986_T1",
"type": "Gene_or_gene_product",
"text": [
"Cdc25A"
],
"offsets": [
[
18,
24
]
],
"normalized": []
},
{
"id": "PMID-11313986_T2",
"type": "Gene_or_gene_product",
"text": [
"E7"
],
"offsets": [
... | [
{
"id": "PMID-11313986_E1",
"type": "Regulation",
"trigger": {
"text": [
"Regulation"
],
"offsets": [
[
0,
10
]
]
},
"arguments": [
{
"role": "Theme",
"ref_id": "PMID-11313986_T1"
},
{
"... | [] | [] |
43 | PMID-11355576 | [
{
"id": "PMID-11355576__text",
"type": "abstract",
"text": [
"[Molecular mechanisms controlling the cell cycle: fundamental aspects and implications for oncology]. \nINTRODUCTION: Comprehension of cell cycle regulation mechanisms has progressed very quickly these past few years and regulators of t... | [
{
"id": "PMID-11355576_T1",
"type": "Simple_chemical",
"text": [
"serine"
],
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[
817,
823
]
],
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},
{
"id": "PMID-11355576_T2",
"type": "Simple_chemical",
"text": [
"threonine"
],
"offsets": [
... | [
{
"id": "PMID-11355576_E1",
"type": "Regulation",
"trigger": {
"text": [
"controlling"
],
"offsets": [
[
22,
33
]
]
},
"arguments": [
{
"role": "Theme",
"ref_id": "PMID-11355576_E2"
}
]
},
{
... | [
{
"id": "PMID-11355576_1",
"entity_ids": [
"PMID-11355576_T3",
"PMID-11355576_T4"
]
},
{
"id": "PMID-11355576_2",
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"PMID-11355576_T12",
"PMID-11355576_T13"
]
},
{
"id": "PMID-11355576_3",
"entity_ids": [
"PMID-11355576_T33",
... | [] |
44 | PMID-11420729 | [
{
"id": "PMID-11420729__text",
"type": "abstract",
"text": [
"The Rb/chromatin connection and epigenetic control: opinion. \nThe balance between cell differentiation and proliferation is regulated at the transcriptional level. In the cell cycle, the transition from G1 to S phase (G1/S transition) ... | [
{
"id": "PMID-11420729_T1",
"type": "Gene_or_gene_product",
"text": [
"Rb"
],
"offsets": [
[
4,
6
]
],
"normalized": []
},
{
"id": "PMID-11420729_T2",
"type": "Cellular_component",
"text": [
"chromatin"
],
"offsets": [
... | [
{
"id": "PMID-11420729_E1",
"type": "Pathway",
"trigger": {
"text": [
"cell cycle"
],
"offsets": [
[
171,
181
]
]
},
"arguments": []
},
{
"id": "PMID-11420729_E2",
"type": "Negative_regulation",
"trigger": {
... | [] | [] |
45 | PMID-11438700 | [
{
"id": "PMID-11438700__text",
"type": "abstract",
"text": [
"Activation of NF-kappa B by nontypeable Hemophilus influenzae is mediated by toll-like receptor 2-TAK1-dependent NIK-IKK alpha /beta-I kappa B alpha and MKK3/6-p38 MAP kinase signaling pathways in epithelial cells. \nNontypeable Hemophi... | [
{
"id": "PMID-11438700_T1",
"type": "Complex",
"text": [
"NF-kappa B"
],
"offsets": [
[
14,
24
]
],
"normalized": []
},
{
"id": "PMID-11438700_T2",
"type": "Gene_or_gene_product",
"text": [
"toll-like receptor 2"
],
"offsets... | [
{
"id": "PMID-11438700_E1",
"type": "Activation",
"trigger": {
"text": [
"Activation"
],
"offsets": [
[
0,
10
]
]
},
"arguments": [
{
"role": "Theme",
"ref_id": "PMID-11438700_T1"
}
]
},
{
... | [
{
"id": "PMID-11438700_1",
"entity_ids": [
"PMID-11438700_T21",
"PMID-11438700_T22"
]
},
{
"id": "PMID-11438700_2",
"entity_ids": [
"PMID-11438700_T23",
"PMID-11438700_T24"
]
}
] | [] |
46 | PMID-11441107 | [
{
"id": "PMID-11441107__text",
"type": "abstract",
"text": [
"Cooperation of Toll-like receptor 2 and 6 for cellular activation by soluble tuberculosis factor and Borrelia burgdorferi outer surface protein A lipoprotein: role of Toll-interacting protein and IL-1 receptor signaling molecules in Tol... | [
{
"id": "PMID-11441107_T1",
"type": "Gene_or_gene_product",
"text": [
"Toll-like receptor 2"
],
"offsets": [
[
15,
35
]
],
"normalized": []
},
{
"id": "PMID-11441107_T2",
"type": "Gene_or_gene_product",
"text": [
"6"
],
"off... | [
{
"id": "PMID-11441107_E1",
"type": "Binding",
"trigger": {
"text": [
"Cooperation"
],
"offsets": [
[
0,
11
]
]
},
"arguments": [
{
"role": "Theme",
"ref_id": "PMID-11441107_T1"
},
{
"ro... | [
{
"id": "PMID-11441107_1",
"entity_ids": [
"PMID-11441107_T8",
"PMID-11441107_T9"
]
},
{
"id": "PMID-11441107_2",
"entity_ids": [
"PMID-11441107_T17",
"PMID-11441107_T16"
]
},
{
"id": "PMID-11441107_3",
"entity_ids": [
"PMID-11441107_T19",
... | [] |
47 | PMID-11454693 | [
{
"id": "PMID-11454693__text",
"type": "abstract",
"text": [
"Inhibition of promyelocytic leukemia (PML)/retinoic acid receptor-alpha and PML expression in acute promyelocytic leukemia cells by anti-PML peptide nucleic acid. \nThe fusion protein promyelocytic leukemia (PML)/retinoic acid receptor ... | [
{
"id": "PMID-11454693_T1",
"type": "Gene_or_gene_product",
"text": [
"promyelocytic leukemia"
],
"offsets": [
[
14,
36
]
],
"normalized": []
},
{
"id": "PMID-11454693_T2",
"type": "Gene_or_gene_product",
"text": [
"PML"
],
... | [
{
"id": "PMID-11454693_E1",
"type": "Negative_regulation",
"trigger": {
"text": [
"Inhibition"
],
"offsets": [
[
0,
10
]
]
},
"arguments": [
{
"role": "Cause",
"ref_id": "PMID-11454693_T6"
},
{
... | [
{
"id": "PMID-11454693_1",
"entity_ids": [
"PMID-11454693_T1",
"PMID-11454693_T2"
]
},
{
"id": "PMID-11454693_2",
"entity_ids": [
"PMID-11454693_T7",
"PMID-11454693_T8"
]
},
{
"id": "PMID-11454693_3",
"entity_ids": [
"PMID-11454693_T12",
"P... | [] |
48 | PMID-11470804 | [
{
"id": "PMID-11470804__text",
"type": "abstract",
"text": [
"Molecular identification and characterization of two medium-chain acyl-CoA synthetases, MACS1 and the Sa gene product. \nIn this study, we identified and characterized two murine cDNAs encoding medium-chain acyl-CoA synthetase (MACS). O... | [
{
"id": "PMID-11470804_T1",
"type": "Gene_or_gene_product",
"text": [
"medium-chain acyl-CoA synthetases"
],
"offsets": [
[
53,
86
]
],
"normalized": []
},
{
"id": "PMID-11470804_T2",
"type": "Gene_or_gene_product",
"text": [
"MACS1... | [
{
"id": "PMID-11470804_E1",
"type": "Gene_expression",
"trigger": {
"text": [
"expressed"
],
"offsets": [
[
355,
364
]
]
},
"arguments": [
{
"role": "Theme",
"ref_id": "PMID-11470804_T7"
}
]
},
... | [
{
"id": "PMID-11470804_1",
"entity_ids": [
"PMID-11470804_T4",
"PMID-11470804_T5"
]
},
{
"id": "PMID-11470804_2",
"entity_ids": [
"PMID-11470804_T7",
"PMID-11470804_T8"
]
}
] | [] |
49 | PMID-11483512 | [
{
"id": "PMID-11483512__text",
"type": "abstract",
"text": [
"PIG-S and PIG-T, essential for GPI anchor attachment to proteins, form a complex with GAA1 and GPI8. \nMany eukaryotic cell surface proteins are anchored to the plasma membrane via glycosylphosphatidylinositol (GPI). The GPI transamidas... | [
{
"id": "PMID-11483512_T1",
"type": "Gene_or_gene_product",
"text": [
"PIG-S"
],
"offsets": [
[
0,
5
]
],
"normalized": []
},
{
"id": "PMID-11483512_T2",
"type": "Gene_or_gene_product",
"text": [
"PIG-T"
],
"offsets": [
... | [
{
"id": "PMID-11483512_E1",
"type": "Positive_regulation",
"trigger": {
"text": [
"essential"
],
"offsets": [
[
17,
26
]
]
},
"arguments": [
{
"role": "Theme",
"ref_id": "PMID-11483512_E3"
},
{
... | [
{
"id": "PMID-11483512_1",
"entity_ids": [
"PMID-11483512_T35",
"PMID-11483512_T36"
]
},
{
"id": "PMID-11483512_2",
"entity_ids": [
"PMID-11483512_T37",
"PMID-11483512_T38"
]
}
] | [] |
50 | PMID-11485410 | [
{
"id": "PMID-11485410__text",
"type": "abstract",
"text": [
"Disruption of NF-kappa B signaling and chemokine gene activation by retroviral mediated expression of IKK gamma/NEMO mutants. \nPhosphorylation of I kappa Bs--the cytoplasmic inhibitors of the NF-kappa B transcription factors--is the ke... | [
{
"id": "PMID-11485410_T1",
"type": "Complex",
"text": [
"NF-kappa B"
],
"offsets": [
[
14,
24
]
],
"normalized": []
},
{
"id": "PMID-11485410_T2",
"type": "Gene_or_gene_product",
"text": [
"IKK gamma"
],
"offsets": [
... | [
{
"id": "PMID-11485410_E1",
"type": "Negative_regulation",
"trigger": {
"text": [
"Disruption"
],
"offsets": [
[
0,
10
]
]
},
"arguments": [
{
"role": "Theme",
"ref_id": "PMID-11485410_E2"
}
]
}... | [
{
"id": "PMID-11485410_1",
"entity_ids": [
"PMID-11485410_T2",
"PMID-11485410_T3"
]
},
{
"id": "PMID-11485410_2",
"entity_ids": [
"PMID-11485410_T9",
"PMID-11485410_T10"
]
},
{
"id": "PMID-11485410_3",
"entity_ids": [
"PMID-11485410_T11",
"... | [] |
51 | PMID-11486005 | [
{
"id": "PMID-11486005__text",
"type": "abstract",
"text": [
"Regulation of Snf1 kinase. Activation requires phosphorylation of threonine 210 by an upstream kinase as well as a distinct step mediated by the Snf4 subunit. \nThe yeast Snf1 kinase and its metazoan orthologues, the AMP-activated prote... | [
{
"id": "PMID-11486005_T1",
"type": "Complex",
"text": [
"Snf1"
],
"offsets": [
[
14,
18
]
],
"normalized": []
},
{
"id": "PMID-11486005_T2",
"type": "Simple_chemical",
"text": [
"threonine 210"
],
"offsets": [
[
... | [
{
"id": "PMID-11486005_E1",
"type": "Regulation",
"trigger": {
"text": [
"Regulation"
],
"offsets": [
[
0,
10
]
]
},
"arguments": [
{
"role": "Theme",
"ref_id": "PMID-11486005_T1"
}
]
},
{
... | [] | [] |
52 | PMID-11562353 | [
{
"id": "PMID-11562353__text",
"type": "abstract",
"text": [
"Mechanisms controlling differential promoter-occupancy by the yeast forkhead proteins Fkh1p and Fkh2p: implications for regulating the cell cycle and differentiation. \nThe roles of DNA and Mcm1p interactions in determining the overlapp... | [
{
"id": "PMID-11562353_T1",
"type": "Gene_or_gene_product",
"text": [
"forkhead"
],
"offsets": [
[
68,
76
]
],
"normalized": []
},
{
"id": "PMID-11562353_T2",
"type": "Gene_or_gene_product",
"text": [
"Fkh1p"
],
"offsets": [... | [
{
"id": "PMID-11562353_E1",
"type": "Regulation",
"trigger": {
"text": [
"regulating"
],
"offsets": [
[
120,
130
]
]
},
"arguments": [
{
"role": "Theme",
"ref_id": "PMID-11562353_E2"
}
]
},
{
... | [] | [] |
53 | PMID-11593391 | [
{
"id": "PMID-11593391__text",
"type": "abstract",
"text": [
"Defects in transcription coupled repair interfere with expression of p90(MDM2) in response to ultraviolet light. \nUltraviolet (UV) irradiation transiently stabilizes p53 through a mechanism that may require a decrease in the activity o... | [
{
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54 | PMID-11606759 | [
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55 | PMID-11677243 | [
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56 | PMID-11691836 | [
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57 | PMID-11723111 | [
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58 | PMID-11726501 | [
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59 | PMID-11729323 | [
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60 | PMID-11751856 | [
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61 | PMID-11801686 | [
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62 | PMID-11802770 | [
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63 | PMID-11832211 | [
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64 | PMID-11836257 | [
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"type": "abstract",
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65 | PMID-11839797 | [
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66 | PMID-11847219 | [
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67 | PMID-11877380 | [
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68 | PMID-11909531 | [
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70 | PMID-11959842 | [
{
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71 | PMID-11959850 | [
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"type": "abstract",
"text": [
"Kinetic mechanism of activation of the Cdk2/cyclin A complex. Key role of the C-lobe of the Cdk. \nEukaryotic cell cycle progression is controlled by the ordered action of cyclin-dependent kinases, activation of which occurs through the... | [
{
"id": "PMID-11959850_T1",
"type": "Complex",
"text": [
"Cdk2/cyclin A"
],
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[
39,
52
]
],
"normalized": []
},
{
"id": "PMID-11959850_T2",
"type": "Gene_or_gene_product",
"text": [
"Cdk"
],
"offsets": [
[
... | [
{
"id": "PMID-11959850_E1",
"type": "Activation",
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"text": [
"activation"
],
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[
21,
31
]
]
},
"arguments": [
{
"role": "Theme",
"ref_id": "PMID-11959850_T1"
}
]
},
{
... | [
{
"id": "PMID-11959850_1",
"entity_ids": [
"PMID-11959850_T8",
"PMID-11959850_T9"
]
}
] | [] |
72 | PMID-11971008 | [
{
"id": "PMID-11971008__text",
"type": "abstract",
"text": [
"Divergence of apoptosis-inducing and preventing signals in bacteria-faced macrophages through myeloid differentiation factor 88 and IL-1 receptor-associated kinase members. \nThe induction of apoptosis in host cells is a common strategy... | [
{
"id": "PMID-11971008_T1",
"type": "Gene_or_gene_product",
"text": [
"myeloid differentiation factor 88"
],
"offsets": [
[
94,
127
]
],
"normalized": []
},
{
"id": "PMID-11971008_T2",
"type": "Gene_or_gene_product",
"text": [
"IL-1... | [
{
"id": "PMID-11971008_E1",
"type": "Pathway",
"trigger": {
"text": [
"apoptosis"
],
"offsets": [
[
14,
23
]
]
},
"arguments": []
},
{
"id": "PMID-11971008_E2",
"type": "Positive_regulation",
"trigger": {
"... | [
{
"id": "PMID-11971008_1",
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"PMID-11971008_T4",
"PMID-11971008_T3"
]
},
{
"id": "PMID-11971008_2",
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"PMID-11971008_T13",
"PMID-11971008_T12"
]
},
{
"id": "PMID-11971008_3",
"entity_ids": [
"PMID-11971008_T20",
... | [] |
73 | PMID-11994509 | [
{
"id": "PMID-11994509__text",
"type": "abstract",
"text": [
"Glycosylphosphatidylinositol-anchored mucin-like glycoproteins isolated from Trypanosoma cruzi trypomastigotes induce in vivo leukocyte recruitment dependent on MCP-1 production by IFN-gamma-primed-macrophages. \nGlycosylphosphatidylino... | [
{
"id": "PMID-11994509_T1",
"type": "Gene_or_gene_product",
"text": [
"Glycosylphosphatidylinositol-anchored mucin-like glycoproteins"
],
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[
0,
62
]
],
"normalized": []
},
{
"id": "PMID-11994509_T2",
"type": "Gene_or_gene_product"... | [
{
"id": "PMID-11994509_E1",
"type": "Gene_expression",
"trigger": {
"text": [
"production"
],
"offsets": [
[
167,
177
]
]
},
"arguments": [
{
"role": "Theme",
"ref_id": "PMID-11994509_T2"
}
]
},... | [
{
"id": "PMID-11994509_1",
"entity_ids": [
"PMID-11994509_T5",
"PMID-11994509_T4"
]
}
] | [] |
74 | PMID-12015078 | [
{
"id": "PMID-12015078__text",
"type": "abstract",
"text": [
"[Study of the effects of quercetin on PML gene and protein expression and localization in leukemia cells]. \nOBJECTIVE: To investigate PML gene and protein expression and localization in leukemia cell lines. METHODS: Cell morphology was... | [
{
"id": "PMID-12015078_T1",
"type": "Simple_chemical",
"text": [
"quercetin"
],
"offsets": [
[
25,
34
]
],
"normalized": []
},
{
"id": "PMID-12015078_T2",
"type": "Gene_or_gene_product",
"text": [
"PML"
],
"offsets": [
... | [
{
"id": "PMID-12015078_E1",
"type": "Regulation",
"trigger": {
"text": [
"effects"
],
"offsets": [
[
14,
21
]
]
},
"arguments": [
{
"role": "Cause",
"ref_id": "PMID-12015078_T1"
},
{
"ro... | [] | [] |
75 | PMID-12015319 | [
{
"id": "PMID-12015319__text",
"type": "abstract",
"text": [
"A 63-base pair DNA segment containing an Sp1 site but not a canonical E2F site can confer growth-dependent and E2F-mediated transcriptional stimulation of the human ASK gene encoding the regulatory subunit for human Cdc7-related kinase.... | [
{
"id": "PMID-12015319_T1",
"type": "Gene_or_gene_product",
"text": [
"Sp1"
],
"offsets": [
[
41,
44
]
],
"normalized": []
},
{
"id": "PMID-12015319_T2",
"type": "Gene_or_gene_product",
"text": [
"E2F"
],
"offsets": [
... | [
{
"id": "PMID-12015319_E1",
"type": "Positive_regulation",
"trigger": {
"text": [
"confer"
],
"offsets": [
[
83,
89
]
]
},
"arguments": [
{
"role": "Theme",
"ref_id": "PMID-12015319_E3"
}
]
},
... | [] | [] |
76 | PMID-12080070 | [
{
"id": "PMID-12080070__text",
"type": "abstract",
"text": [
"The turn motif is a phosphorylation switch that regulates the binding of Hsp70 to protein kinase C. \nHeat shock proteins play central roles in ensuring the correct folding and maturation of cellular proteins. Here we show that the heat... | [
{
"id": "PMID-12080070_T1",
"type": "Gene_or_gene_product",
"text": [
"Hsp70"
],
"offsets": [
[
73,
78
]
],
"normalized": []
},
{
"id": "PMID-12080070_T2",
"type": "Gene_or_gene_product",
"text": [
"protein kinase C"
],
"off... | [
{
"id": "PMID-12080070_E1",
"type": "Regulation",
"trigger": {
"text": [
"regulates"
],
"offsets": [
[
48,
57
]
]
},
"arguments": [
{
"role": "Theme",
"ref_id": "PMID-12080070_E2"
}
]
},
{
... | [
{
"id": "PMID-12080070_1",
"entity_ids": [
"PMID-12080070_T23",
"PMID-12080070_T24"
]
}
] | [] |
77 | PMID-12084455 | [
{
"id": "PMID-12084455__text",
"type": "abstract",
"text": [
"Homeostatic control of uridine and the role of uridine phosphorylase: a biological and clinical update. \nUridine, a pyrimidine nucleoside essential for the synthesis of RNA and bio-membranes, is a crucial element in the regulation of n... | [
{
"id": "PMID-12084455_T1",
"type": "Simple_chemical",
"text": [
"uridine"
],
"offsets": [
[
23,
30
]
],
"normalized": []
},
{
"id": "PMID-12084455_T2",
"type": "Gene_or_gene_product",
"text": [
"uridine phosphorylase"
],
"o... | [
{
"id": "PMID-12084455_E1",
"type": "Regulation",
"trigger": {
"text": [
"control"
],
"offsets": [
[
12,
19
]
]
},
"arguments": [
{
"role": "Theme",
"ref_id": "PMID-12084455_T1"
}
]
},
{
"... | [
{
"id": "PMID-12084455_1",
"entity_ids": [
"PMID-12084455_T10",
"PMID-12084455_T11"
]
}
] | [] |
78 | PMID-12119352 | [
{
"id": "PMID-12119352__text",
"type": "abstract",
"text": [
"Potential role of phosphatidylinositol 3 kinase, rather than DNA-dependent protein kinase, in CpG DNA-induced immune activation. \nUnmethylated CpG motifs present in bacterial DNA stimulate a strong innate immune response. There is evid... | [
{
"id": "PMID-12119352_T1",
"type": "Gene_or_gene_product",
"text": [
"phosphatidylinositol 3 kinase"
],
"offsets": [
[
18,
47
]
],
"normalized": []
},
{
"id": "PMID-12119352_T2",
"type": "Complex",
"text": [
"DNA-dependent protein ... | [
{
"id": "PMID-12119352_E1",
"type": "Negative_regulation",
"trigger": {
"text": [
"inhibitor"
],
"offsets": [
[
336,
345
]
]
},
"arguments": [
{
"role": "Cause",
"ref_id": "PMID-12119352_T5"
},
... | [
{
"id": "PMID-12119352_1",
"entity_ids": [
"PMID-12119352_T3",
"PMID-12119352_T4"
]
}
] | [] |
79 | PMID-12138177 | [
{
"id": "PMID-12138177__text",
"type": "abstract",
"text": [
"Transcriptional regulation of the mdm2 oncogene by p53 requires TRRAP acetyltransferase complexes. \nThe p53 tumor suppressor regulates the cellular response to genetic damage through its function as a sequence-specific transcription fa... | [
{
"id": "PMID-12138177_T1",
"type": "Gene_or_gene_product",
"text": [
"mdm2"
],
"offsets": [
[
34,
38
]
],
"normalized": []
},
{
"id": "PMID-12138177_T2",
"type": "Gene_or_gene_product",
"text": [
"p53"
],
"offsets": [
... | [
{
"id": "PMID-12138177_E1",
"type": "Regulation",
"trigger": {
"text": [
"regulation"
],
"offsets": [
[
16,
26
]
]
},
"arguments": [
{
"role": "Theme",
"ref_id": "PMID-12138177_T1"
},
{
... | [] | [] |
80 | PMID-12231510 | [
{
"id": "PMID-12231510__text",
"type": "abstract",
"text": [
"The FKBP12-rapamycin-associated protein (FRAP) is a CLIP-170 kinase. \nCLIP-170/Restin belongs to a family of conserved microtubule (MT)-associated proteins, which are important for MT organization and functions. CLIP-170 is a phosphopr... | [
{
"id": "PMID-12231510_T1",
"type": "Gene_or_gene_product",
"text": [
"FKBP12-rapamycin-associated protein"
],
"offsets": [
[
4,
39
]
],
"normalized": []
},
{
"id": "PMID-12231510_T2",
"type": "Gene_or_gene_product",
"text": [
"FRAP... | [
{
"id": "PMID-12231510_E1",
"type": "Phosphorylation",
"trigger": {
"text": [
"kinase"
],
"offsets": [
[
61,
67
]
]
},
"arguments": [
{
"role": "Theme",
"ref_id": "PMID-12231510_T3"
},
{
... | [
{
"id": "PMID-12231510_1",
"entity_ids": [
"PMID-12231510_T1",
"PMID-12231510_T2"
]
},
{
"id": "PMID-12231510_2",
"entity_ids": [
"PMID-12231510_T4",
"PMID-12231510_T5"
]
},
{
"id": "PMID-12231510_3",
"entity_ids": [
"PMID-12231510_T6",
"PM... | [] |
81 | PMID-12368233 | [
{
"id": "PMID-12368233__text",
"type": "abstract",
"text": [
"Opposing regulatory roles of E2F in human telomerase reverse transcriptase (hTERT) gene expression in human tumor and normal somatic cells. \nTelomerase activity is closely correlated with cellular proliferative activity in human tissue... | [
{
"id": "PMID-12368233_T1",
"type": "Gene_or_gene_product",
"text": [
"E2F"
],
"offsets": [
[
29,
32
]
],
"normalized": []
},
{
"id": "PMID-12368233_T2",
"type": "Gene_or_gene_product",
"text": [
"human telomerase reverse transcript... | [
{
"id": "PMID-12368233_E1",
"type": "Negative_regulation",
"trigger": {
"text": [
"Opposing"
],
"offsets": [
[
0,
8
]
]
},
"arguments": [
{
"role": "Theme",
"ref_id": "PMID-12368233_E2"
}
]
},
... | [
{
"id": "PMID-12368233_1",
"entity_ids": [
"PMID-12368233_T2",
"PMID-12368233_T3"
]
},
{
"id": "PMID-12368233_2",
"entity_ids": [
"PMID-12368233_T7",
"PMID-12368233_T8"
]
}
] | [] |
82 | PMID-12402045 | [
{
"id": "PMID-12402045__text",
"type": "abstract",
"text": [
"The Doc1 subunit is a processivity factor for the anaphase-promoting complex. \nUbiquitin-mediated proteolysis of securin and mitotic cyclins is essential for exit from mitosis. The final step in ubiquitination of these and other protei... | [
{
"id": "PMID-12402045_T1",
"type": "Gene_or_gene_product",
"text": [
"Doc1"
],
"offsets": [
[
4,
8
]
],
"normalized": []
},
{
"id": "PMID-12402045_T2",
"type": "Complex",
"text": [
"anaphase-promoting complex"
],
"offsets":... | [
{
"id": "PMID-12402045_E1",
"type": "Positive_regulation",
"trigger": {
"text": [
"mediated"
],
"offsets": [
[
89,
97
]
]
},
"arguments": [
{
"role": "Cause",
"ref_id": "PMID-12402045_T3"
},
{
... | [
{
"id": "PMID-12402045_1",
"entity_ids": [
"PMID-12402045_T6",
"PMID-12402045_T7"
]
},
{
"id": "PMID-12402045_2",
"entity_ids": [
"PMID-12402045_T14",
"PMID-12402045_T15"
]
}
] | [] |
83 | PMID-12410835 | [
{
"id": "PMID-12410835__text",
"type": "abstract",
"text": [
"Regulation of the yeast Rlm1 transcription factor by the Mpk1 cell wall integrity MAP kinase. \nThe Mpk1 MAP kinase of the Saccharomyces cerevisiae cell wall integrity signalling pathway phosphorylates and activates the Rlm1 transcripti... | [
{
"id": "PMID-12410835_T1",
"type": "Gene_or_gene_product",
"text": [
"Rlm1"
],
"offsets": [
[
24,
28
]
],
"normalized": []
},
{
"id": "PMID-12410835_T2",
"type": "Gene_or_gene_product",
"text": [
"Mpk1"
],
"offsets": [
... | [
{
"id": "PMID-12410835_E1",
"type": "Regulation",
"trigger": {
"text": [
"Regulation"
],
"offsets": [
[
0,
10
]
]
},
"arguments": [
{
"role": "Theme",
"ref_id": "PMID-12410835_T1"
},
{
"... | [] | [] |
84 | PMID-12455995 | [
{
"id": "PMID-12455995__text",
"type": "abstract",
"text": [
"GTPase-activating proteins for Cdc42. \nThe Rho-type GTPase, Cdc42, has been implicated in a variety of functions in the yeast life cycle, including septin organization for cytokinesis, pheromone response, and haploid invasive growth. A... | [
{
"id": "PMID-12455995_T1",
"type": "Gene_or_gene_product",
"text": [
"GTPase-activating proteins"
],
"offsets": [
[
0,
26
]
],
"normalized": []
},
{
"id": "PMID-12455995_T2",
"type": "Gene_or_gene_product",
"text": [
"Cdc42"
],... | [
{
"id": "PMID-12455995_E1",
"type": "Positive_regulation",
"trigger": {
"text": [
"implicated"
],
"offsets": [
[
76,
86
]
]
},
"arguments": [
{
"role": "Theme",
"ref_id": "PMID-12455995_T5"
},
{... | [
{
"id": "PMID-12455995_1",
"entity_ids": [
"PMID-12455995_T6",
"PMID-12455995_T7"
]
},
{
"id": "PMID-12455995_2",
"entity_ids": [
"PMID-12455995_T18",
"PMID-12455995_T19"
]
}
] | [] |
85 | PMID-12459251 | [
{
"id": "PMID-12459251__text",
"type": "abstract",
"text": [
"Linking cyclins to transcriptional control. \nCell cycle activation is coordinated by D-type cyclins which are rate limiting and essential for the progression through the G1 phase of the cell cycle. D-type cyclins bind to and activate t... | [
{
"id": "PMID-12459251_T1",
"type": "Gene_or_gene_product",
"text": [
"cyclins"
],
"offsets": [
[
8,
15
]
],
"normalized": []
},
{
"id": "PMID-12459251_T2",
"type": "Gene_or_gene_product",
"text": [
"D-type cyclins"
],
"offs... | [
{
"id": "PMID-12459251_E1",
"type": "Pathway",
"trigger": {
"text": [
"Cell cycle"
],
"offsets": [
[
45,
55
]
]
},
"arguments": []
},
{
"id": "PMID-12459251_E2",
"type": "Positive_regulation",
"trigger": {
... | [
{
"id": "PMID-12459251_1",
"entity_ids": [
"PMID-12459251_T7",
"PMID-12459251_T8"
]
},
{
"id": "PMID-12459251_2",
"entity_ids": [
"PMID-12459251_T26",
"PMID-12459251_T27"
]
}
] | [] |
86 | PMID-12482958 | [
{
"id": "PMID-12482958__text",
"type": "abstract",
"text": [
"The transformation suppressor Pdcd4 is a novel eukaryotic translation initiation factor 4A binding protein that inhibits translation. \nPdcd4 is a novel transformation suppressor that inhibits tumor promoter-induced neoplastic transform... | [
{
"id": "PMID-12482958_T1",
"type": "Gene_or_gene_product",
"text": [
"Pdcd4"
],
"offsets": [
[
30,
35
]
],
"normalized": []
},
{
"id": "PMID-12482958_T2",
"type": "Gene_or_gene_product",
"text": [
"eukaryotic translation initiation... | [
{
"id": "PMID-12482958_E1",
"type": "Binding",
"trigger": {
"text": [
"binding"
],
"offsets": [
[
91,
98
]
]
},
"arguments": [
{
"role": "Theme",
"ref_id": "PMID-12482958_T2"
},
{
"role"... | [] | [] |
87 | PMID-12511557 | [
{
"id": "PMID-12511557__text",
"type": "abstract",
"text": [
"The tuberin-hamartin complex negatively regulates beta-catenin signaling activity. \nTuberous sclerosis complex (TSC) is characterized by the formation of hamartomas in multiple organs resulting from mutations in the TSC1 or TSC2 gene. ... | [
{
"id": "PMID-12511557_T1",
"type": "Complex",
"text": [
"tuberin-hamartin"
],
"offsets": [
[
4,
20
]
],
"normalized": []
},
{
"id": "PMID-12511557_T2",
"type": "Gene_or_gene_product",
"text": [
"beta-catenin"
],
"offsets": ... | [
{
"id": "PMID-12511557_E1",
"type": "Negative_regulation",
"trigger": {
"text": [
"negatively regulates"
],
"offsets": [
[
29,
49
]
]
},
"arguments": [
{
"role": "Cause",
"ref_id": "PMID-12511557_T1"
... | [] | [] |
88 | PMID-12551923 | [
{
"id": "PMID-12551923__text",
"type": "abstract",
"text": [
"Phosphorylation of Raf-1 by p21-activated kinase 1 and Src regulates Raf-1 autoinhibition. \nExposure of cells to mitogens or growth factors stimulates Raf-1 activity through a complex mechanism that involves binding to active Ras, phos... | [
{
"id": "PMID-12551923_T1",
"type": "Gene_or_gene_product",
"text": [
"Raf-1"
],
"offsets": [
[
19,
24
]
],
"normalized": []
},
{
"id": "PMID-12551923_T2",
"type": "Gene_or_gene_product",
"text": [
"p21-activated kinase 1"
],
... | [
{
"id": "PMID-12551923_E1",
"type": "Phosphorylation",
"trigger": {
"text": [
"Phosphorylation"
],
"offsets": [
[
0,
15
]
]
},
"arguments": [
{
"role": "Theme",
"ref_id": "PMID-12551923_T1"
},
{... | [] | [] |
89 | PMID-12586352 | [
{
"id": "PMID-12586352__text",
"type": "abstract",
"text": [
"Structure-function analysis of the A20-binding inhibitor of NF-kappa B activation, ABIN-1. \nNuclear factor kappa B (NF-kappa B)-dependent gene expression plays an important role in numerous cellular processes including stress responses... | [
{
"id": "PMID-12586352_T1",
"type": "Gene_or_gene_product",
"text": [
"A20-binding inhibitor of NF-kappa B activation"
],
"offsets": [
[
35,
81
]
],
"normalized": []
},
{
"id": "PMID-12586352_T2",
"type": "Gene_or_gene_product",
"text": [... | [
{
"id": "PMID-12586352_E1",
"type": "Positive_regulation",
"trigger": {
"text": [
"dependent"
],
"offsets": [
[
387,
396
]
]
},
"arguments": [
{
"role": "Cause",
"ref_id": "PMID-12586352_T5"
},
... | [
{
"id": "PMID-12586352_1",
"entity_ids": [
"PMID-12586352_T3",
"PMID-12586352_T4"
]
},
{
"id": "PMID-12586352_2",
"entity_ids": [
"PMID-12586352_T9",
"PMID-12586352_T10"
]
},
{
"id": "PMID-12586352_3",
"entity_ids": [
"PMID-12586352_T12",
"... | [] |
90 | PMID-12588975 | [
{
"id": "PMID-12588975__text",
"type": "abstract",
"text": [
"The C terminus of initiation factor 4E-binding protein 1 contains multiple regulatory features that influence its function and phosphorylation. \nEukaryotic initiation factor 4E (eIF4E) binds the mRNA cap structure and forms eIF4F compl... | [
{
"id": "PMID-12588975_T1",
"type": "Gene_or_gene_product",
"text": [
"initiation factor 4E-binding protein 1"
],
"offsets": [
[
18,
56
]
],
"normalized": []
},
{
"id": "PMID-12588975_T2",
"type": "Gene_or_gene_product",
"text": [
"... | [
{
"id": "PMID-12588975_E1",
"type": "Regulation",
"trigger": {
"text": [
"influence"
],
"offsets": [
[
100,
109
]
]
},
"arguments": [
{
"role": "Theme",
"ref_id": "PMID-12588975_E2"
}
]
},
{
... | [
{
"id": "PMID-12588975_1",
"entity_ids": [
"PMID-12588975_T2",
"PMID-12588975_T3"
]
}
] | [] |
91 | PMID-12611887 | [
{
"id": "PMID-12611887__text",
"type": "abstract",
"text": [
"Regulation of the cyclin D3 promoter by E2F1. \nWe have previously demonstrated that ectopic expression of E2F1 is sufficient to drive quiescent cells into S phase and that E2F1 expression can contribute to oncogenic transformation. Key... | [
{
"id": "PMID-12611887_T1",
"type": "Gene_or_gene_product",
"text": [
"cyclin D3"
],
"offsets": [
[
18,
27
]
],
"normalized": []
},
{
"id": "PMID-12611887_T2",
"type": "Gene_or_gene_product",
"text": [
"E2F1"
],
"offsets": [... | [
{
"id": "PMID-12611887_E1",
"type": "Regulation",
"trigger": {
"text": [
"Regulation"
],
"offsets": [
[
0,
10
]
]
},
"arguments": [
{
"role": "Theme",
"ref_id": "PMID-12611887_T1"
},
{
"... | [
{
"id": "PMID-12611887_1",
"entity_ids": [
"PMID-12611887_T10",
"PMID-12611887_T11"
]
}
] | [] |
92 | PMID-12616480 | [
{
"id": "PMID-12616480__text",
"type": "abstract",
"text": [
"Phosphatidylinositol 3-kinase is involved in Toll-like receptor 4-mediated cytokine expression in mouse macrophages. \nRecent evidence suggests a role for phosphatidylinositol (PI) 3-kinase in various inflammatory responses. In this stu... | [
{
"id": "PMID-12616480_T1",
"type": "Gene_or_gene_product",
"text": [
"Phosphatidylinositol 3-kinase"
],
"offsets": [
[
0,
29
]
],
"normalized": []
},
{
"id": "PMID-12616480_T2",
"type": "Gene_or_gene_product",
"text": [
"Toll-like ... | [
{
"id": "PMID-12616480_E1",
"type": "Positive_regulation",
"trigger": {
"text": [
"stimulation"
],
"offsets": [
[
431,
442
]
]
},
"arguments": [
{
"role": "Cause",
"ref_id": "PMID-12616480_T7"
},
... | [
{
"id": "PMID-12616480_1",
"entity_ids": [
"PMID-12616480_T9",
"PMID-12616480_T10"
]
},
{
"id": "PMID-12616480_2",
"entity_ids": [
"PMID-12616480_T12",
"PMID-12616480_T13"
]
},
{
"id": "PMID-12616480_3",
"entity_ids": [
"PMID-12616480_T21",
... | [] |
93 | PMID-12618428 | [
{
"id": "PMID-12618428__text",
"type": "abstract",
"text": [
"14-3-3beta is a p90 ribosomal S6 kinase (RSK) isoform 1-binding protein that negatively regulates RSK kinase activity. \np90 ribosomal S6 kinase 1 (RSK1) is a serine/threonine kinase that is activated by extracellular signal-related kin... | [
{
"id": "PMID-12618428_T1",
"type": "Gene_or_gene_product",
"text": [
"14-3-3beta"
],
"offsets": [
[
0,
10
]
],
"normalized": []
},
{
"id": "PMID-12618428_T2",
"type": "Gene_or_gene_product",
"text": [
"p90 ribosomal S6 kinase (RSK)... | [
{
"id": "PMID-12618428_E1",
"type": "Binding",
"trigger": {
"text": [
"binding"
],
"offsets": [
[
56,
63
]
]
},
"arguments": [
{
"role": "Theme",
"ref_id": "PMID-12618428_T2"
},
{
"role"... | [
{
"id": "PMID-12618428_1",
"entity_ids": [
"PMID-12618428_T4",
"PMID-12618428_T5"
]
}
] | [] |
94 | PMID-12625370 | [
{
"id": "PMID-12625370__text",
"type": "abstract",
"text": [
"E2F1 activates the human p53 promoter and overcomes the repressive effect of hepatitis B viral X protein (Hbx) on the p53 promoter. \nThe functional effect of the interaction of E2F1 and hepatitis B virus X protein (HBx) on the promoter... | [
{
"id": "PMID-12625370_T1",
"type": "Gene_or_gene_product",
"text": [
"E2F1"
],
"offsets": [
[
0,
4
]
],
"normalized": []
},
{
"id": "PMID-12625370_T2",
"type": "Gene_or_gene_product",
"text": [
"p53"
],
"offsets": [
[... | [
{
"id": "PMID-12625370_E1",
"type": "Activation",
"trigger": {
"text": [
"activates"
],
"offsets": [
[
5,
14
]
]
},
"arguments": [
{
"role": "Theme",
"ref_id": "PMID-12625370_T2"
},
{
"r... | [
{
"id": "PMID-12625370_1",
"entity_ids": [
"PMID-12625370_T3",
"PMID-12625370_T4"
]
},
{
"id": "PMID-12625370_2",
"entity_ids": [
"PMID-12625370_T7",
"PMID-12625370_T8"
]
},
{
"id": "PMID-12625370_3",
"entity_ids": [
"PMID-12625370_T10",
"P... | [] |
95 | PMID-12636916 | [
{
"id": "PMID-12636916__text",
"type": "abstract",
"text": [
"Phosphorylation-dependent regulation of septin dynamics during the cell cycle. \nSeptins are GTPases involved in cytokinesis. In yeast, they form a ring at the cleavage site. Using FRAP, we show that septins are mobile within the ring a... | [
{
"id": "PMID-12636916_T1",
"type": "Gene_or_gene_product",
"text": [
"septin"
],
"offsets": [
[
40,
46
]
],
"normalized": []
},
{
"id": "PMID-12636916_T2",
"type": "Gene_or_gene_product",
"text": [
"Septins"
],
"offsets": [... | [
{
"id": "PMID-12636916_E1",
"type": "Positive_regulation",
"trigger": {
"text": [
"dependent"
],
"offsets": [
[
16,
25
]
]
},
"arguments": [
{
"role": "Theme",
"ref_id": "PMID-12636916_E2"
}
]
}... | [
{
"id": "PMID-12636916_1",
"entity_ids": [
"PMID-12636916_T11",
"PMID-12636916_T12"
]
}
] | [] |
96 | PMID-12642668 | [
{
"id": "PMID-12642668__text",
"type": "abstract",
"text": [
"The role of disulfide bonds in the assembly and function of MD-2. \nMD-2 is a secreted glycoprotein that binds to the extracellular domain of Toll-like receptor 4 (TLR4) and is required for the activation of TLR4 by lipopolysaccharide (... | [
{
"id": "PMID-12642668_T1",
"type": "Gene_or_gene_product",
"text": [
"MD-2"
],
"offsets": [
[
60,
64
]
],
"normalized": []
},
{
"id": "PMID-12642668_T2",
"type": "Gene_or_gene_product",
"text": [
"MD-2"
],
"offsets": [
... | [
{
"id": "PMID-12642668_E1",
"type": "Regulation",
"trigger": {
"text": [
"role"
],
"offsets": [
[
4,
8
]
]
},
"arguments": [
{
"role": "Theme",
"ref_id": "PMID-12642668_T1"
}
]
},
{
"id": ... | [
{
"id": "PMID-12642668_1",
"entity_ids": [
"PMID-12642668_T4",
"PMID-12642668_T5"
]
},
{
"id": "PMID-12642668_2",
"entity_ids": [
"PMID-12642668_T7",
"PMID-12642668_T8"
]
}
] | [] |
97 | PMID-12663670 | [
{
"id": "PMID-12663670__text",
"type": "abstract",
"text": [
"The activation of c-Jun NH2-terminal kinase (JNK) by DNA-damaging agents serves to promote drug resistance via activating transcription factor 2 (ATF2)-dependent enhanced DNA repair. \nThe activating transcription factor 2 (ATF2) is a m... | [
{
"id": "PMID-12663670_T1",
"type": "Gene_or_gene_product",
"text": [
"c-Jun NH2-terminal kinase"
],
"offsets": [
[
18,
43
]
],
"normalized": []
},
{
"id": "PMID-12663670_T2",
"type": "Gene_or_gene_product",
"text": [
"JNK"
],
... | [
{
"id": "PMID-12663670_E1",
"type": "Activation",
"trigger": {
"text": [
"activation"
],
"offsets": [
[
4,
14
]
]
},
"arguments": [
{
"role": "Theme",
"ref_id": "PMID-12663670_T1"
}
]
},
{
... | [
{
"id": "PMID-12663670_1",
"entity_ids": [
"PMID-12663670_T1",
"PMID-12663670_T2"
]
},
{
"id": "PMID-12663670_2",
"entity_ids": [
"PMID-12663670_T3",
"PMID-12663670_T4"
]
},
{
"id": "PMID-12663670_3",
"entity_ids": [
"PMID-12663670_T5",
"PM... | [] |
98 | PMID-12665581 | [
{
"id": "PMID-12665581__text",
"type": "abstract",
"text": [
"NPAT expression is regulated by E2F and is essential for cell cycle progression. \nNPAT is an in vivo substrate of cyclin E-Cdk2 kinase and is thought to play a critical role in coordinated transcriptional activation of histone genes du... | [
{
"id": "PMID-12665581_T1",
"type": "Gene_or_gene_product",
"text": [
"NPAT"
],
"offsets": [
[
0,
4
]
],
"normalized": []
},
{
"id": "PMID-12665581_T2",
"type": "Gene_or_gene_product",
"text": [
"E2F"
],
"offsets": [
[... | [
{
"id": "PMID-12665581_E1",
"type": "Gene_expression",
"trigger": {
"text": [
"expression"
],
"offsets": [
[
5,
15
]
]
},
"arguments": [
{
"role": "Theme",
"ref_id": "PMID-12665581_T1"
}
]
},
... | [] | [] |
99 | PMID-12667410 | [
{
"id": "PMID-12667410__text",
"type": "abstract",
"text": [
"Effects of red orpiment on cell morphology and expression of PML mRNA and protein in NB4 and HL-60 cells. \nOBJECTIVE: To investigate the effects of red orpiment on cell morphology, expression of promyelocytic leukemia (PML) mRNA and it... | [
{
"id": "PMID-12667410_T1",
"type": "Gene_or_gene_product",
"text": [
"PML"
],
"offsets": [
[
61,
64
]
],
"normalized": []
},
{
"id": "PMID-12667410_T2",
"type": "Gene_or_gene_product",
"text": [
"promyelocytic leukemia"
],
... | [
{
"id": "PMID-12667410_E1",
"type": "Regulation",
"trigger": {
"text": [
"Effects"
],
"offsets": [
[
0,
7
]
]
},
"arguments": [
{
"role": "Theme",
"ref_id": "PMID-12667410_E2"
}
]
},
{
"id... | [
{
"id": "PMID-12667410_1",
"entity_ids": [
"PMID-12667410_T2",
"PMID-12667410_T3"
]
},
{
"id": "PMID-12667410_2",
"entity_ids": [
"PMID-12667410_T8",
"PMID-12667410_T9"
]
}
] | [] |
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