id int64 1 50 | type stringclasses 2
values | age int64 33 91 | molecular_phenotype stringclasses 8
values | treatment_status stringlengths 15 60 ⌀ | special_considerations stringlengths 22 166 | description stringlengths 110 557 | ground_truth stringlengths 21 250 | system_prompt stringclasses 1
value | question_all stringlengths 1.12k 1.57k | question_neoadjuvant stringlengths 223 670 | question_surgery stringlengths 221 668 | question_adjuvant stringlengths 232 679 | question_genetic stringlengths 220 667 | question_support stringlengths 195 642 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | naive | 65 | ER+/PR+/HER2- | Newly diagnosed | Very small tumor (T1), no nodes involved | 65 year old woman. Post-menopausal. Grade 1, invasive ductal carcinoma (IDC). Strongly ER positive (8/8), PR positive (5/8) and HER2 negative (IHC of 0). Found to have a 8 mm tumor. No nodes involved. ECOG performance status of 0. Ki-67 of 18%. | Lumpectomy, radiation, endocrine therapy. No need for chemo. | You are a helpful medical assistant, and I am a breast cancer specialist using this tool to help me evaluate a breast cancer case. Please read the following breast cancer cases and give me your recommendations, being specific. Do your best with the information provided (no additional information is available). | Your reply should be structured in the following format:
Case summary: Summarize the salient features of the case
Neoadjuvant therapy: Is neoadjuvant therapy indicated? If yes, what neoadjuvant therapy should be used.
Surgery: Is surgery indicated here? Considering this case in particular, describe if the surgical p... | For this case, is neoadjuvant therapy indicated? If yes, what specific neoadjuvant therapy should be used? Case: 65 year old woman. Post-menopausal. Grade 1, invasive ductal carcinoma (IDC). Strongly ER positive (8/8), PR positive (5/8) and HER2 negative (IHC of 0). Found to have a 8 mm tumor. No nodes involved. ECOG p... | For this case, what surgical approach is indicated? What specific pathology findings should I watch for? Case: 65 year old woman. Post-menopausal. Grade 1, invasive ductal carcinoma (IDC). Strongly ER positive (8/8), PR positive (5/8) and HER2 negative (IHC of 0). Found to have a 8 mm tumor. No nodes involved. ECOG per... | After surgery, what adjuvant therapy should be initiated for this case? Be specific about medications and sequence. Case: 65 year old woman. Post-menopausal. Grade 1, invasive ductal carcinoma (IDC). Strongly ER positive (8/8), PR positive (5/8) and HER2 negative (IHC of 0). Found to have a 8 mm tumor. No nodes involve... | Based on NCCN guidelines, does this patient meet criteria for genetic testing? What about their family? Case: 65 year old woman. Post-menopausal. Grade 1, invasive ductal carcinoma (IDC). Strongly ER positive (8/8), PR positive (5/8) and HER2 negative (IHC of 0). Found to have a 8 mm tumor. No nodes involved. ECOG perf... | What psychosocial support and counseling would you recommend for this patient? Case: 65 year old woman. Post-menopausal. Grade 1, invasive ductal carcinoma (IDC). Strongly ER positive (8/8), PR positive (5/8) and HER2 negative (IHC of 0). Found to have a 8 mm tumor. No nodes involved. ECOG performance status of 0. Ki-6... |
2 | naive | 41 | ER+/PR+/HER2- | Newly diagnosed | Very small tumor (T1), no nodes involved | 41 year old woman. Premenopausal. Grade 1 invasive ductal carcinoma (IDC). ER strongly positive (8/8), PR strongly positive (8/8), HER2 negative (IHC 0). 8 mm tumor. OncotypeDX returns with a score of 12. No nodes involved. ECOG performance status of 0. Ki-67 of 25%. | Lumpectomy, radiation, endocrine therapy with tamoxifen | You are a helpful medical assistant, and I am a breast cancer specialist using this tool to help me evaluate a breast cancer case. Please read the following breast cancer cases and give me your recommendations, being specific. Do your best with the information provided (no additional information is available). | Your reply should be structured in the following format:
Case summary: Summarize the salient features of the case
Neoadjuvant therapy: Is neoadjuvant therapy indicated? If yes, what neoadjuvant therapy should be used.
Surgery: Is surgery indicated here? Considering this case in particular, describe if the surgical p... | For this case, is neoadjuvant therapy indicated? If yes, what specific neoadjuvant therapy should be used? Case: 41 year old woman. Premenopausal. Grade 1 invasive ductal carcinoma (IDC). ER strongly positive (8/8), PR strongly positive (8/8), HER2 negative (IHC 0). 8 mm tumor. OncotypeDX returns with a score of 12. No... | For this case, what surgical approach is indicated? What specific pathology findings should I watch for? Case: 41 year old woman. Premenopausal. Grade 1 invasive ductal carcinoma (IDC). ER strongly positive (8/8), PR strongly positive (8/8), HER2 negative (IHC 0). 8 mm tumor. OncotypeDX returns with a score of 12. No n... | After surgery, what adjuvant therapy should be initiated for this case? Be specific about medications and sequence. Case: 41 year old woman. Premenopausal. Grade 1 invasive ductal carcinoma (IDC). ER strongly positive (8/8), PR strongly positive (8/8), HER2 negative (IHC 0). 8 mm tumor. OncotypeDX returns with a score ... | Based on NCCN guidelines, does this patient meet criteria for genetic testing? What about their family? Case: 41 year old woman. Premenopausal. Grade 1 invasive ductal carcinoma (IDC). ER strongly positive (8/8), PR strongly positive (8/8), HER2 negative (IHC 0). 8 mm tumor. OncotypeDX returns with a score of 12. No no... | What psychosocial support and counseling would you recommend for this patient? Case: 41 year old woman. Premenopausal. Grade 1 invasive ductal carcinoma (IDC). ER strongly positive (8/8), PR strongly positive (8/8), HER2 negative (IHC 0). 8 mm tumor. OncotypeDX returns with a score of 12. No nodes involved. ECOG perfor... |
3 | naive | 41 | ER+/PR+/HER2- | Newly diagnosed | Large tumor (T3), no nodes involved | 41 year old woman. Premenopausal. Grade 3 invasive ductal carcinoma (IDC). ER strongly positive (7/8), PR positive (5/8), HER2 negative (IHC 0). 8.2 cm tumor. No nodes involved. OncotypeDX is run, score of 36. ECOG performance status of 0. Ki-67 of 34%. | Surgery followed by adjuvant chemotherapy (Taxotere and cyclophosphamide), radiation and then endocrine therapy. | You are a helpful medical assistant, and I am a breast cancer specialist using this tool to help me evaluate a breast cancer case. Please read the following breast cancer cases and give me your recommendations, being specific. Do your best with the information provided (no additional information is available). | Your reply should be structured in the following format:
Case summary: Summarize the salient features of the case
Neoadjuvant therapy: Is neoadjuvant therapy indicated? If yes, what neoadjuvant therapy should be used.
Surgery: Is surgery indicated here? Considering this case in particular, describe if the surgical p... | For this case, is neoadjuvant therapy indicated? If yes, what specific neoadjuvant therapy should be used? Case: 41 year old woman. Premenopausal. Grade 3 invasive ductal carcinoma (IDC). ER strongly positive (7/8), PR positive (5/8), HER2 negative (IHC 0). 8.2 cm tumor. No nodes involved. OncotypeDX is run, score of 3... | For this case, what surgical approach is indicated? What specific pathology findings should I watch for? Case: 41 year old woman. Premenopausal. Grade 3 invasive ductal carcinoma (IDC). ER strongly positive (7/8), PR positive (5/8), HER2 negative (IHC 0). 8.2 cm tumor. No nodes involved. OncotypeDX is run, score of 36.... | After surgery, what adjuvant therapy should be initiated for this case? Be specific about medications and sequence. Case: 41 year old woman. Premenopausal. Grade 3 invasive ductal carcinoma (IDC). ER strongly positive (7/8), PR positive (5/8), HER2 negative (IHC 0). 8.2 cm tumor. No nodes involved. OncotypeDX is run, s... | Based on NCCN guidelines, does this patient meet criteria for genetic testing? What about their family? Case: 41 year old woman. Premenopausal. Grade 3 invasive ductal carcinoma (IDC). ER strongly positive (7/8), PR positive (5/8), HER2 negative (IHC 0). 8.2 cm tumor. No nodes involved. OncotypeDX is run, score of 36. ... | What psychosocial support and counseling would you recommend for this patient? Case: 41 year old woman. Premenopausal. Grade 3 invasive ductal carcinoma (IDC). ER strongly positive (7/8), PR positive (5/8), HER2 negative (IHC 0). 8.2 cm tumor. No nodes involved. OncotypeDX is run, score of 36. ECOG performance status o... |
4 | naive | 41 | ER+/PR+/HER2- | Newly diagnosed | Large tumor (T3), no nodes involved | 41 year old woman. Premenopausal. Grade 3 invasive ductal carcinoma (IDC). ER strongly positive (7/8), PR positive (5/8), and HER2 negative (IHC 0). 8.2 cm tumor. No nodes involved. OncotypeDX is run, score of 11. ECOG performance status of 0. Ki-67 of 30%. | Surgery followed by radiation and endocrine therapy. No role of chemotherapy here. | You are a helpful medical assistant, and I am a breast cancer specialist using this tool to help me evaluate a breast cancer case. Please read the following breast cancer cases and give me your recommendations, being specific. Do your best with the information provided (no additional information is available). | Your reply should be structured in the following format:
Case summary: Summarize the salient features of the case
Neoadjuvant therapy: Is neoadjuvant therapy indicated? If yes, what neoadjuvant therapy should be used.
Surgery: Is surgery indicated here? Considering this case in particular, describe if the surgical p... | For this case, is neoadjuvant therapy indicated? If yes, what specific neoadjuvant therapy should be used? Case: 41 year old woman. Premenopausal. Grade 3 invasive ductal carcinoma (IDC). ER strongly positive (7/8), PR positive (5/8), and HER2 negative (IHC 0). 8.2 cm tumor. No nodes involved. OncotypeDX is run, score ... | For this case, what surgical approach is indicated? What specific pathology findings should I watch for? Case: 41 year old woman. Premenopausal. Grade 3 invasive ductal carcinoma (IDC). ER strongly positive (7/8), PR positive (5/8), and HER2 negative (IHC 0). 8.2 cm tumor. No nodes involved. OncotypeDX is run, score of... | After surgery, what adjuvant therapy should be initiated for this case? Be specific about medications and sequence. Case: 41 year old woman. Premenopausal. Grade 3 invasive ductal carcinoma (IDC). ER strongly positive (7/8), PR positive (5/8), and HER2 negative (IHC 0). 8.2 cm tumor. No nodes involved. OncotypeDX is ru... | Based on NCCN guidelines, does this patient meet criteria for genetic testing? What about their family? Case: 41 year old woman. Premenopausal. Grade 3 invasive ductal carcinoma (IDC). ER strongly positive (7/8), PR positive (5/8), and HER2 negative (IHC 0). 8.2 cm tumor. No nodes involved. OncotypeDX is run, score of ... | What psychosocial support and counseling would you recommend for this patient? Case: 41 year old woman. Premenopausal. Grade 3 invasive ductal carcinoma (IDC). ER strongly positive (7/8), PR positive (5/8), and HER2 negative (IHC 0). 8.2 cm tumor. No nodes involved. OncotypeDX is run, score of 11. ECOG performance stat... |
5 | naive | 41 | ER+/PR+/HER2- | Newly diagnosed | Small tumor (T1), nodal involvement | 41 year old woman, premenopausal. Grade 2 invasive ductal carcinoma (IDC), ER positive (8/8), PR positive (8/8) and HER2 negative (IHC of 0). 2.0 cm tumor. 1 lymph node positive out of 3 (3 total removed). OncotypeDX score of 24. | Surgery followed by radiation and adjuvant chemotherapy therapy. Then endocrine therapy. | You are a helpful medical assistant, and I am a breast cancer specialist using this tool to help me evaluate a breast cancer case. Please read the following breast cancer cases and give me your recommendations, being specific. Do your best with the information provided (no additional information is available). | Your reply should be structured in the following format:
Case summary: Summarize the salient features of the case
Neoadjuvant therapy: Is neoadjuvant therapy indicated? If yes, what neoadjuvant therapy should be used.
Surgery: Is surgery indicated here? Considering this case in particular, describe if the surgical p... | For this case, is neoadjuvant therapy indicated? If yes, what specific neoadjuvant therapy should be used? Case: 41 year old woman, premenopausal. Grade 2 invasive ductal carcinoma (IDC), ER positive (8/8), PR positive (8/8) and HER2 negative (IHC of 0). 2.0 cm tumor. 1 lymph node positive out of 3 (3 total removed). O... | For this case, what surgical approach is indicated? What specific pathology findings should I watch for? Case: 41 year old woman, premenopausal. Grade 2 invasive ductal carcinoma (IDC), ER positive (8/8), PR positive (8/8) and HER2 negative (IHC of 0). 2.0 cm tumor. 1 lymph node positive out of 3 (3 total removed). Onc... | After surgery, what adjuvant therapy should be initiated for this case? Be specific about medications and sequence. Case: 41 year old woman, premenopausal. Grade 2 invasive ductal carcinoma (IDC), ER positive (8/8), PR positive (8/8) and HER2 negative (IHC of 0). 2.0 cm tumor. 1 lymph node positive out of 3 (3 total re... | Based on NCCN guidelines, does this patient meet criteria for genetic testing? What about their family? Case: 41 year old woman, premenopausal. Grade 2 invasive ductal carcinoma (IDC), ER positive (8/8), PR positive (8/8) and HER2 negative (IHC of 0). 2.0 cm tumor. 1 lymph node positive out of 3 (3 total removed). Onco... | What psychosocial support and counseling would you recommend for this patient? Case: 41 year old woman, premenopausal. Grade 2 invasive ductal carcinoma (IDC), ER positive (8/8), PR positive (8/8) and HER2 negative (IHC of 0). 2.0 cm tumor. 1 lymph node positive out of 3 (3 total removed). OncotypeDX score of 24. |
6 | naive | 56 | ER+/PR-/HER2- | Newly diagnosed | Small tumor (T1), nodal involvement | 56 year old woman, post-menopausal. Grade 2 invasive ductal carcinoma (IDC). ER positive (8/8), PR negative, HER2 negative (IHC of 0). Tumor size is 1.7 cm, two positive lymph nodes out of 4. OncotypeDX score of 34. | Surgery and chemotherapy, radiation, then endocrine therapy. | You are a helpful medical assistant, and I am a breast cancer specialist using this tool to help me evaluate a breast cancer case. Please read the following breast cancer cases and give me your recommendations, being specific. Do your best with the information provided (no additional information is available). | Your reply should be structured in the following format:
Case summary: Summarize the salient features of the case
Neoadjuvant therapy: Is neoadjuvant therapy indicated? If yes, what neoadjuvant therapy should be used.
Surgery: Is surgery indicated here? Considering this case in particular, describe if the surgical p... | For this case, is neoadjuvant therapy indicated? If yes, what specific neoadjuvant therapy should be used? Case: 56 year old woman, post-menopausal. Grade 2 invasive ductal carcinoma (IDC). ER positive (8/8), PR negative, HER2 negative (IHC of 0). Tumor size is 1.7 cm, two positive lymph nodes out of 4. OncotypeDX scor... | For this case, what surgical approach is indicated? What specific pathology findings should I watch for? Case: 56 year old woman, post-menopausal. Grade 2 invasive ductal carcinoma (IDC). ER positive (8/8), PR negative, HER2 negative (IHC of 0). Tumor size is 1.7 cm, two positive lymph nodes out of 4. OncotypeDX score ... | After surgery, what adjuvant therapy should be initiated for this case? Be specific about medications and sequence. Case: 56 year old woman, post-menopausal. Grade 2 invasive ductal carcinoma (IDC). ER positive (8/8), PR negative, HER2 negative (IHC of 0). Tumor size is 1.7 cm, two positive lymph nodes out of 4. Oncoty... | Based on NCCN guidelines, does this patient meet criteria for genetic testing? What about their family? Case: 56 year old woman, post-menopausal. Grade 2 invasive ductal carcinoma (IDC). ER positive (8/8), PR negative, HER2 negative (IHC of 0). Tumor size is 1.7 cm, two positive lymph nodes out of 4. OncotypeDX score o... | What psychosocial support and counseling would you recommend for this patient? Case: 56 year old woman, post-menopausal. Grade 2 invasive ductal carcinoma (IDC). ER positive (8/8), PR negative, HER2 negative (IHC of 0). Tumor size is 1.7 cm, two positive lymph nodes out of 4. OncotypeDX score of 34. |
7 | naive | 56 | ER+/PR-/HER2- | Newly diagnosed | Small tumor (T1), nodal involvement | 56 year old woman, post-menopausal. Grade 2 invasive ductal carcinoma (IDC). ER positive (8/8), PR negative, HER2 negative (IHC of 0). Tumor size 1.7 cm, two positive lymph nodes out of 4. Oncotype 13. | Surgery, and endocrine therapy. No chemotherapy. | You are a helpful medical assistant, and I am a breast cancer specialist using this tool to help me evaluate a breast cancer case. Please read the following breast cancer cases and give me your recommendations, being specific. Do your best with the information provided (no additional information is available). | Your reply should be structured in the following format:
Case summary: Summarize the salient features of the case
Neoadjuvant therapy: Is neoadjuvant therapy indicated? If yes, what neoadjuvant therapy should be used.
Surgery: Is surgery indicated here? Considering this case in particular, describe if the surgical p... | For this case, is neoadjuvant therapy indicated? If yes, what specific neoadjuvant therapy should be used? Case: 56 year old woman, post-menopausal. Grade 2 invasive ductal carcinoma (IDC). ER positive (8/8), PR negative, HER2 negative (IHC of 0). Tumor size 1.7 cm, two positive lymph nodes out of 4. Oncotype 13. | For this case, what surgical approach is indicated? What specific pathology findings should I watch for? Case: 56 year old woman, post-menopausal. Grade 2 invasive ductal carcinoma (IDC). ER positive (8/8), PR negative, HER2 negative (IHC of 0). Tumor size 1.7 cm, two positive lymph nodes out of 4. Oncotype 13. | After surgery, what adjuvant therapy should be initiated for this case? Be specific about medications and sequence. Case: 56 year old woman, post-menopausal. Grade 2 invasive ductal carcinoma (IDC). ER positive (8/8), PR negative, HER2 negative (IHC of 0). Tumor size 1.7 cm, two positive lymph nodes out of 4. Oncotype ... | Based on NCCN guidelines, does this patient meet criteria for genetic testing? What about their family? Case: 56 year old woman, post-menopausal. Grade 2 invasive ductal carcinoma (IDC). ER positive (8/8), PR negative, HER2 negative (IHC of 0). Tumor size 1.7 cm, two positive lymph nodes out of 4. Oncotype 13. | What psychosocial support and counseling would you recommend for this patient? Case: 56 year old woman, post-menopausal. Grade 2 invasive ductal carcinoma (IDC). ER positive (8/8), PR negative, HER2 negative (IHC of 0). Tumor size 1.7 cm, two positive lymph nodes out of 4. Oncotype 13. |
8 | naive | 56 | ER-/PR-/HER2+ | Newly diagnosed | Small tumor (T2), nodal involvement, no distant metastasis | 56 year old woman, postmenopausal. Grade 3 invasive ductal carcinoma (IDC). ER negative, PR negative and HER2 positive. Tumor size is 3 cm. Biopsy proven positive lymph nodes. No distant metastatic disease. | Neoadjuvant chemotherapy. TCHP 6 cycles. Surgery, radiation, targeted therapy with HP if she had PR, or TDM1 if had residual disease at time of surgery. | You are a helpful medical assistant, and I am a breast cancer specialist using this tool to help me evaluate a breast cancer case. Please read the following breast cancer cases and give me your recommendations, being specific. Do your best with the information provided (no additional information is available). | Your reply should be structured in the following format:
Case summary: Summarize the salient features of the case
Neoadjuvant therapy: Is neoadjuvant therapy indicated? If yes, what neoadjuvant therapy should be used.
Surgery: Is surgery indicated here? Considering this case in particular, describe if the surgical p... | For this case, is neoadjuvant therapy indicated? If yes, what specific neoadjuvant therapy should be used? Case: 56 year old woman, postmenopausal. Grade 3 invasive ductal carcinoma (IDC). ER negative, PR negative and HER2 positive. Tumor size is 3 cm. Biopsy proven positive lymph nodes. No distant metastatic disease. | For this case, what surgical approach is indicated? What specific pathology findings should I watch for? Case: 56 year old woman, postmenopausal. Grade 3 invasive ductal carcinoma (IDC). ER negative, PR negative and HER2 positive. Tumor size is 3 cm. Biopsy proven positive lymph nodes. No distant metastatic disease. | After surgery, what adjuvant therapy should be initiated for this case? Be specific about medications and sequence. Case: 56 year old woman, postmenopausal. Grade 3 invasive ductal carcinoma (IDC). ER negative, PR negative and HER2 positive. Tumor size is 3 cm. Biopsy proven positive lymph nodes. No distant metastatic ... | Based on NCCN guidelines, does this patient meet criteria for genetic testing? What about their family? Case: 56 year old woman, postmenopausal. Grade 3 invasive ductal carcinoma (IDC). ER negative, PR negative and HER2 positive. Tumor size is 3 cm. Biopsy proven positive lymph nodes. No distant metastatic disease. | What psychosocial support and counseling would you recommend for this patient? Case: 56 year old woman, postmenopausal. Grade 3 invasive ductal carcinoma (IDC). ER negative, PR negative and HER2 positive. Tumor size is 3 cm. Biopsy proven positive lymph nodes. No distant metastatic disease. |
9 | naive | 57 | ER+/PR+/HER2+ | Newly diagnosed | Very small tumor (T1), no nodes involved, no distant metastasis | 57 year old woman, postmenopausal. Grade 2 invasive ductal carcinoma (IDC). ER positive, PR positive and HER2 positive. Tumor size is 8 mm, node negative. No distant metastatic disease. | Surgery first. Confirm disease. Neoadjuvant is only done for 2cm or greater tumors. Adjuvant taxol + Herceptin for 12 weeks, and Herceptin to continue for 9 more months per APT trial. Endocrine therapy as well. | You are a helpful medical assistant, and I am a breast cancer specialist using this tool to help me evaluate a breast cancer case. Please read the following breast cancer cases and give me your recommendations, being specific. Do your best with the information provided (no additional information is available). | Your reply should be structured in the following format:
Case summary: Summarize the salient features of the case
Neoadjuvant therapy: Is neoadjuvant therapy indicated? If yes, what neoadjuvant therapy should be used.
Surgery: Is surgery indicated here? Considering this case in particular, describe if the surgical p... | For this case, is neoadjuvant therapy indicated? If yes, what specific neoadjuvant therapy should be used? Case: 57 year old woman, postmenopausal. Grade 2 invasive ductal carcinoma (IDC). ER positive, PR positive and HER2 positive. Tumor size is 8 mm, node negative. No distant metastatic disease. | For this case, what surgical approach is indicated? What specific pathology findings should I watch for? Case: 57 year old woman, postmenopausal. Grade 2 invasive ductal carcinoma (IDC). ER positive, PR positive and HER2 positive. Tumor size is 8 mm, node negative. No distant metastatic disease. | After surgery, what adjuvant therapy should be initiated for this case? Be specific about medications and sequence. Case: 57 year old woman, postmenopausal. Grade 2 invasive ductal carcinoma (IDC). ER positive, PR positive and HER2 positive. Tumor size is 8 mm, node negative. No distant metastatic disease. | Based on NCCN guidelines, does this patient meet criteria for genetic testing? What about their family? Case: 57 year old woman, postmenopausal. Grade 2 invasive ductal carcinoma (IDC). ER positive, PR positive and HER2 positive. Tumor size is 8 mm, node negative. No distant metastatic disease. | What psychosocial support and counseling would you recommend for this patient? Case: 57 year old woman, postmenopausal. Grade 2 invasive ductal carcinoma (IDC). ER positive, PR positive and HER2 positive. Tumor size is 8 mm, node negative. No distant metastatic disease. |
10 | naive | 42 | ER-/PR-/HER2+ | Newly diagnosed | Inflammatory breast cancer, T4 disease affecting the chest wall, large tumor, N3 disease, bulky nodes, not metastatic | 42 year old woman. Premenopausal. Inflammatory breast cancer. Grade 3 invasive ductal carcinoma (IDC). ER negative, PR negative, HER2 positive. She has T4 disease (Affecting the chest wall and skin). Measures at 10 cm. N3 disease (supraclavicular disease) with bulky fixed lymph nodes. Not metastatic. | Chemotherapy – TCHP for 6 cycles. If responds well, modified radical mastectomy with axillary lymph node dissection and removal of all the skin. Go for radiation and then adjuvant therapy which can either be HP or T-DM1 depending on residual disease. | You are a helpful medical assistant, and I am a breast cancer specialist using this tool to help me evaluate a breast cancer case. Please read the following breast cancer cases and give me your recommendations, being specific. Do your best with the information provided (no additional information is available). | Your reply should be structured in the following format:
Case summary: Summarize the salient features of the case
Neoadjuvant therapy: Is neoadjuvant therapy indicated? If yes, what neoadjuvant therapy should be used.
Surgery: Is surgery indicated here? Considering this case in particular, describe if the surgical p... | For this case, is neoadjuvant therapy indicated? If yes, what specific neoadjuvant therapy should be used? Case: 42 year old woman. Premenopausal. Inflammatory breast cancer. Grade 3 invasive ductal carcinoma (IDC). ER negative, PR negative, HER2 positive. She has T4 disease (Affecting the chest wall and skin). Measure... | For this case, what surgical approach is indicated? What specific pathology findings should I watch for? Case: 42 year old woman. Premenopausal. Inflammatory breast cancer. Grade 3 invasive ductal carcinoma (IDC). ER negative, PR negative, HER2 positive. She has T4 disease (Affecting the chest wall and skin). Measures ... | After surgery, what adjuvant therapy should be initiated for this case? Be specific about medications and sequence. Case: 42 year old woman. Premenopausal. Inflammatory breast cancer. Grade 3 invasive ductal carcinoma (IDC). ER negative, PR negative, HER2 positive. She has T4 disease (Affecting the chest wall and skin)... | Based on NCCN guidelines, does this patient meet criteria for genetic testing? What about their family? Case: 42 year old woman. Premenopausal. Inflammatory breast cancer. Grade 3 invasive ductal carcinoma (IDC). ER negative, PR negative, HER2 positive. She has T4 disease (Affecting the chest wall and skin). Measures a... | What psychosocial support and counseling would you recommend for this patient? Case: 42 year old woman. Premenopausal. Inflammatory breast cancer. Grade 3 invasive ductal carcinoma (IDC). ER negative, PR negative, HER2 positive. She has T4 disease (Affecting the chest wall and skin). Measures at 10 cm. N3 disease (supr... |
11 | naive | 35 | ER+/PR+/HER2+ | Newly diagnosed | Small tumor (T2), no metastatic disease | 35 year old woman, grade 2 invasive ductal carcinoma (IDC). ER positive, PR positive, HER2 positive. Tumor size is 3 cm, node negative, no distant metastatic disease. | TCH for 6 cycles. No pertuzumab because no lymph node disease or T3 tumor. Surgery. Adjuvant targeted therapy would be TDM1 or Herceptin. Then, she will get endocrine therapy. | You are a helpful medical assistant, and I am a breast cancer specialist using this tool to help me evaluate a breast cancer case. Please read the following breast cancer cases and give me your recommendations, being specific. Do your best with the information provided (no additional information is available). | Your reply should be structured in the following format:
Case summary: Summarize the salient features of the case
Neoadjuvant therapy: Is neoadjuvant therapy indicated? If yes, what neoadjuvant therapy should be used.
Surgery: Is surgery indicated here? Considering this case in particular, describe if the surgical p... | For this case, is neoadjuvant therapy indicated? If yes, what specific neoadjuvant therapy should be used? Case: 35 year old woman, grade 2 invasive ductal carcinoma (IDC). ER positive, PR positive, HER2 positive. Tumor size is 3 cm, node negative, no distant metastatic disease. | For this case, what surgical approach is indicated? What specific pathology findings should I watch for? Case: 35 year old woman, grade 2 invasive ductal carcinoma (IDC). ER positive, PR positive, HER2 positive. Tumor size is 3 cm, node negative, no distant metastatic disease. | After surgery, what adjuvant therapy should be initiated for this case? Be specific about medications and sequence. Case: 35 year old woman, grade 2 invasive ductal carcinoma (IDC). ER positive, PR positive, HER2 positive. Tumor size is 3 cm, node negative, no distant metastatic disease. | Based on NCCN guidelines, does this patient meet criteria for genetic testing? What about their family? Case: 35 year old woman, grade 2 invasive ductal carcinoma (IDC). ER positive, PR positive, HER2 positive. Tumor size is 3 cm, node negative, no distant metastatic disease. | What psychosocial support and counseling would you recommend for this patient? Case: 35 year old woman, grade 2 invasive ductal carcinoma (IDC). ER positive, PR positive, HER2 positive. Tumor size is 3 cm, node negative, no distant metastatic disease. |
12 | naive | 45 | ER+/PR+/HER2+ | Newly diagnosed | Small tumor (T1), nodal involvement | 45 year old woman, premenopausal. ER positive, PR positive, HER2 positive. Tumor size is 2 cm. Positive nodes. | Treat neoadjuvant chemo with TCHP. Surgical resection, followed by radiation. Then, hormonal therapy and HP in the adjuvant setting if pathological CR achieved. | You are a helpful medical assistant, and I am a breast cancer specialist using this tool to help me evaluate a breast cancer case. Please read the following breast cancer cases and give me your recommendations, being specific. Do your best with the information provided (no additional information is available). | Your reply should be structured in the following format:
Case summary: Summarize the salient features of the case
Neoadjuvant therapy: Is neoadjuvant therapy indicated? If yes, what neoadjuvant therapy should be used.
Surgery: Is surgery indicated here? Considering this case in particular, describe if the surgical p... | For this case, is neoadjuvant therapy indicated? If yes, what specific neoadjuvant therapy should be used? Case: 45 year old woman, premenopausal. ER positive, PR positive, HER2 positive. Tumor size is 2 cm. Positive nodes. | For this case, what surgical approach is indicated? What specific pathology findings should I watch for? Case: 45 year old woman, premenopausal. ER positive, PR positive, HER2 positive. Tumor size is 2 cm. Positive nodes. | After surgery, what adjuvant therapy should be initiated for this case? Be specific about medications and sequence. Case: 45 year old woman, premenopausal. ER positive, PR positive, HER2 positive. Tumor size is 2 cm. Positive nodes. | Based on NCCN guidelines, does this patient meet criteria for genetic testing? What about their family? Case: 45 year old woman, premenopausal. ER positive, PR positive, HER2 positive. Tumor size is 2 cm. Positive nodes. | What psychosocial support and counseling would you recommend for this patient? Case: 45 year old woman, premenopausal. ER positive, PR positive, HER2 positive. Tumor size is 2 cm. Positive nodes. |
13 | naive | 50 | ER-/PR-/HER2- | Newly diagnosed | Small tumor (T2), very high Ki-67, node negative, no metastasis | 50 year old woman. Pre-menopausal. Grade 3 invasive ductal carcinoma (IDC). Triple negative breast cancer (ER negative, PR negative and HER2 negative). Ki-67 75%. Tumor size is 2.5 cm, node negative, no distant metastatic disease. | KEYNOTE 522 protocol: Neoadjuvant therapy with Pembro + AC, followed by pembro + taxol + carbo. Followed by surgery. If pathological response, just gets adjuvant pembro. Otherwise, Xeloda and pembro together. | You are a helpful medical assistant, and I am a breast cancer specialist using this tool to help me evaluate a breast cancer case. Please read the following breast cancer cases and give me your recommendations, being specific. Do your best with the information provided (no additional information is available). | Your reply should be structured in the following format:
Case summary: Summarize the salient features of the case
Neoadjuvant therapy: Is neoadjuvant therapy indicated? If yes, what neoadjuvant therapy should be used.
Surgery: Is surgery indicated here? Considering this case in particular, describe if the surgical p... | For this case, is neoadjuvant therapy indicated? If yes, what specific neoadjuvant therapy should be used? Case: 50 year old woman. Pre-menopausal. Grade 3 invasive ductal carcinoma (IDC). Triple negative breast cancer (ER negative, PR negative and HER2 negative). Ki-67 75%. Tumor size is 2.5 cm, node negative, no dist... | For this case, what surgical approach is indicated? What specific pathology findings should I watch for? Case: 50 year old woman. Pre-menopausal. Grade 3 invasive ductal carcinoma (IDC). Triple negative breast cancer (ER negative, PR negative and HER2 negative). Ki-67 75%. Tumor size is 2.5 cm, node negative, no distan... | After surgery, what adjuvant therapy should be initiated for this case? Be specific about medications and sequence. Case: 50 year old woman. Pre-menopausal. Grade 3 invasive ductal carcinoma (IDC). Triple negative breast cancer (ER negative, PR negative and HER2 negative). Ki-67 75%. Tumor size is 2.5 cm, node negative... | Based on NCCN guidelines, does this patient meet criteria for genetic testing? What about their family? Case: 50 year old woman. Pre-menopausal. Grade 3 invasive ductal carcinoma (IDC). Triple negative breast cancer (ER negative, PR negative and HER2 negative). Ki-67 75%. Tumor size is 2.5 cm, node negative, no distant... | What psychosocial support and counseling would you recommend for this patient? Case: 50 year old woman. Pre-menopausal. Grade 3 invasive ductal carcinoma (IDC). Triple negative breast cancer (ER negative, PR negative and HER2 negative). Ki-67 75%. Tumor size is 2.5 cm, node negative, no distant metastatic disease. |
14 | naive | 50 | ER-/PR-/HER2- | Newly diagnosed | Very small tumor (T1), very high Ki-67, node negative, no metastasis | 50 year old woman, pre-menopausal. Grade 3 invasive ductal carcinoma (IDC). Triple negative breast cancer (ER negative, PR negative and HER2 negative). Ki-67 85%. Tumor size is 7mm. Node negative. No metastatic disease | Surgery first. No role for neoadjuvant if < 2 cm. If truly has 7 mm on surgery, give TC chemo for 4 cycles. (Clinical trial data would support adjuvant AC -> T, per the ABC trial.) | You are a helpful medical assistant, and I am a breast cancer specialist using this tool to help me evaluate a breast cancer case. Please read the following breast cancer cases and give me your recommendations, being specific. Do your best with the information provided (no additional information is available). | Your reply should be structured in the following format:
Case summary: Summarize the salient features of the case
Neoadjuvant therapy: Is neoadjuvant therapy indicated? If yes, what neoadjuvant therapy should be used.
Surgery: Is surgery indicated here? Considering this case in particular, describe if the surgical p... | For this case, is neoadjuvant therapy indicated? If yes, what specific neoadjuvant therapy should be used? Case: 50 year old woman, pre-menopausal. Grade 3 invasive ductal carcinoma (IDC). Triple negative breast cancer (ER negative, PR negative and HER2 negative). Ki-67 85%. Tumor size is 7mm. Node negative. No metasta... | For this case, what surgical approach is indicated? What specific pathology findings should I watch for? Case: 50 year old woman, pre-menopausal. Grade 3 invasive ductal carcinoma (IDC). Triple negative breast cancer (ER negative, PR negative and HER2 negative). Ki-67 85%. Tumor size is 7mm. Node negative. No metastati... | After surgery, what adjuvant therapy should be initiated for this case? Be specific about medications and sequence. Case: 50 year old woman, pre-menopausal. Grade 3 invasive ductal carcinoma (IDC). Triple negative breast cancer (ER negative, PR negative and HER2 negative). Ki-67 85%. Tumor size is 7mm. Node negative. N... | Based on NCCN guidelines, does this patient meet criteria for genetic testing? What about their family? Case: 50 year old woman, pre-menopausal. Grade 3 invasive ductal carcinoma (IDC). Triple negative breast cancer (ER negative, PR negative and HER2 negative). Ki-67 85%. Tumor size is 7mm. Node negative. No metastatic... | What psychosocial support and counseling would you recommend for this patient? Case: 50 year old woman, pre-menopausal. Grade 3 invasive ductal carcinoma (IDC). Triple negative breast cancer (ER negative, PR negative and HER2 negative). Ki-67 85%. Tumor size is 7mm. Node negative. No metastatic disease |
15 | naive | 59 | ER-/PR-/HER2- | Newly diagnosed | Small tumor (T2), nodal involvement, no metastasis | 59 year old woman, post-menopausal, grade 2 triple negative breast cancer (ER negative, PR negative and HER2 negative). Ki-67 45%. 3-cm tumor size. Biopsy proven lymph nodes, no metastatic disease. | KEYNOTE 522 protocol: Neoadjuvant therapy with Pembro + AC, followed by pembro + taxol + carbo. Followed by surgery. If pathological response, just gets adjuvant pembro. Otherwise, Xeloda and pembro together. | You are a helpful medical assistant, and I am a breast cancer specialist using this tool to help me evaluate a breast cancer case. Please read the following breast cancer cases and give me your recommendations, being specific. Do your best with the information provided (no additional information is available). | Your reply should be structured in the following format:
Case summary: Summarize the salient features of the case
Neoadjuvant therapy: Is neoadjuvant therapy indicated? If yes, what neoadjuvant therapy should be used.
Surgery: Is surgery indicated here? Considering this case in particular, describe if the surgical p... | For this case, is neoadjuvant therapy indicated? If yes, what specific neoadjuvant therapy should be used? Case: 59 year old woman, post-menopausal, grade 2 triple negative breast cancer (ER negative, PR negative and HER2 negative). Ki-67 45%. 3-cm tumor size. Biopsy proven lymph nodes, no metastatic disease. | For this case, what surgical approach is indicated? What specific pathology findings should I watch for? Case: 59 year old woman, post-menopausal, grade 2 triple negative breast cancer (ER negative, PR negative and HER2 negative). Ki-67 45%. 3-cm tumor size. Biopsy proven lymph nodes, no metastatic disease. | After surgery, what adjuvant therapy should be initiated for this case? Be specific about medications and sequence. Case: 59 year old woman, post-menopausal, grade 2 triple negative breast cancer (ER negative, PR negative and HER2 negative). Ki-67 45%. 3-cm tumor size. Biopsy proven lymph nodes, no metastatic disease. | Based on NCCN guidelines, does this patient meet criteria for genetic testing? What about their family? Case: 59 year old woman, post-menopausal, grade 2 triple negative breast cancer (ER negative, PR negative and HER2 negative). Ki-67 45%. 3-cm tumor size. Biopsy proven lymph nodes, no metastatic disease. | What psychosocial support and counseling would you recommend for this patient? Case: 59 year old woman, post-menopausal, grade 2 triple negative breast cancer (ER negative, PR negative and HER2 negative). Ki-67 45%. 3-cm tumor size. Biopsy proven lymph nodes, no metastatic disease. |
16 | naive | 43 | ER-/PR-/HER2- | Newly diagnosed | Small tumor (T1), post-surgery, no nodes involved | 43 year old woman, premenopausal. Already had surgery, 1.2 cm tumor, no nodes involved. Triple negative (ER negative, PR negative and HER2 negative) disease. | Does not qualify for immunotherapy. Radiation after surgery. -Adjuvant chemo with ddAC 4 cycles, followed by weekly taxol or every 3-week Taxotere. | You are a helpful medical assistant, and I am a breast cancer specialist using this tool to help me evaluate a breast cancer case. Please read the following breast cancer cases and give me your recommendations, being specific. Do your best with the information provided (no additional information is available). | Your reply should be structured in the following format:
Case summary: Summarize the salient features of the case
Neoadjuvant therapy: Is neoadjuvant therapy indicated? If yes, what neoadjuvant therapy should be used.
Surgery: Is surgery indicated here? Considering this case in particular, describe if the surgical p... | For this case, is neoadjuvant therapy indicated? If yes, what specific neoadjuvant therapy should be used? Case: 43 year old woman, premenopausal. Already had surgery, 1.2 cm tumor, no nodes involved. Triple negative (ER negative, PR negative and HER2 negative) disease. | For this case, what surgical approach is indicated? What specific pathology findings should I watch for? Case: 43 year old woman, premenopausal. Already had surgery, 1.2 cm tumor, no nodes involved. Triple negative (ER negative, PR negative and HER2 negative) disease. | After surgery, what adjuvant therapy should be initiated for this case? Be specific about medications and sequence. Case: 43 year old woman, premenopausal. Already had surgery, 1.2 cm tumor, no nodes involved. Triple negative (ER negative, PR negative and HER2 negative) disease. | Based on NCCN guidelines, does this patient meet criteria for genetic testing? What about their family? Case: 43 year old woman, premenopausal. Already had surgery, 1.2 cm tumor, no nodes involved. Triple negative (ER negative, PR negative and HER2 negative) disease. | What psychosocial support and counseling would you recommend for this patient? Case: 43 year old woman, premenopausal. Already had surgery, 1.2 cm tumor, no nodes involved. Triple negative (ER negative, PR negative and HER2 negative) disease. |
17 | naive | 45 | ER+/PR+/HER2+ | Newly diagnosed | Small tumor (T1), nodal involvement | 45 year old woman, premenopausal, ER positive, PR positive, HER2 positive. 2 cm in size of tumor. She has positive lymph nodes. | Neoadjuvant chemo (TCHP x6), radiation after. Hormonal therapy and HP in adjuvant setting. | You are a helpful medical assistant, and I am a breast cancer specialist using this tool to help me evaluate a breast cancer case. Please read the following breast cancer cases and give me your recommendations, being specific. Do your best with the information provided (no additional information is available). | Your reply should be structured in the following format:
Case summary: Summarize the salient features of the case
Neoadjuvant therapy: Is neoadjuvant therapy indicated? If yes, what neoadjuvant therapy should be used.
Surgery: Is surgery indicated here? Considering this case in particular, describe if the surgical p... | For this case, is neoadjuvant therapy indicated? If yes, what specific neoadjuvant therapy should be used? Case: 45 year old woman, premenopausal, ER positive, PR positive, HER2 positive. 2 cm in size of tumor. She has positive lymph nodes. | For this case, what surgical approach is indicated? What specific pathology findings should I watch for? Case: 45 year old woman, premenopausal, ER positive, PR positive, HER2 positive. 2 cm in size of tumor. She has positive lymph nodes. | After surgery, what adjuvant therapy should be initiated for this case? Be specific about medications and sequence. Case: 45 year old woman, premenopausal, ER positive, PR positive, HER2 positive. 2 cm in size of tumor. She has positive lymph nodes. | Based on NCCN guidelines, does this patient meet criteria for genetic testing? What about their family? Case: 45 year old woman, premenopausal, ER positive, PR positive, HER2 positive. 2 cm in size of tumor. She has positive lymph nodes. | What psychosocial support and counseling would you recommend for this patient? Case: 45 year old woman, premenopausal, ER positive, PR positive, HER2 positive. 2 cm in size of tumor. She has positive lymph nodes. |
18 | naive | 59 | ER-/PR-/HER2+ | Newly diagnosed | Very small tumor (T1), elected for mastectomy, no nodes involved | 59-year old woman goes to surgery first. 2-mm grade 2 invasive ductal carcinoma (IDC), ER negative, PR negative, HER2 positive. No nodes positive. She had elected for mastectomy. | No treatment necessary. | You are a helpful medical assistant, and I am a breast cancer specialist using this tool to help me evaluate a breast cancer case. Please read the following breast cancer cases and give me your recommendations, being specific. Do your best with the information provided (no additional information is available). | Your reply should be structured in the following format:
Case summary: Summarize the salient features of the case
Neoadjuvant therapy: Is neoadjuvant therapy indicated? If yes, what neoadjuvant therapy should be used.
Surgery: Is surgery indicated here? Considering this case in particular, describe if the surgical p... | For this case, is neoadjuvant therapy indicated? If yes, what specific neoadjuvant therapy should be used? Case: 59-year old woman goes to surgery first. 2-mm grade 2 invasive ductal carcinoma (IDC), ER negative, PR negative, HER2 positive. No nodes positive. She had elected for mastectomy. | For this case, what surgical approach is indicated? What specific pathology findings should I watch for? Case: 59-year old woman goes to surgery first. 2-mm grade 2 invasive ductal carcinoma (IDC), ER negative, PR negative, HER2 positive. No nodes positive. She had elected for mastectomy. | After surgery, what adjuvant therapy should be initiated for this case? Be specific about medications and sequence. Case: 59-year old woman goes to surgery first. 2-mm grade 2 invasive ductal carcinoma (IDC), ER negative, PR negative, HER2 positive. No nodes positive. She had elected for mastectomy. | Based on NCCN guidelines, does this patient meet criteria for genetic testing? What about their family? Case: 59-year old woman goes to surgery first. 2-mm grade 2 invasive ductal carcinoma (IDC), ER negative, PR negative, HER2 positive. No nodes positive. She had elected for mastectomy. | What psychosocial support and counseling would you recommend for this patient? Case: 59-year old woman goes to surgery first. 2-mm grade 2 invasive ductal carcinoma (IDC), ER negative, PR negative, HER2 positive. No nodes positive. She had elected for mastectomy. |
19 | naive | 59 | ER-/PR-/HER2- | Newly diagnosed | Very small tumor (T1), no nodes involved, post-mastectomy | 59-year old woman goes to surgery. 2-mm grade 2 invasive ductal carcinoma (IDC), ER negative, PR negative, HER2 negative. No nodes positive. Had mastectomy. | No treatment necessary | You are a helpful medical assistant, and I am a breast cancer specialist using this tool to help me evaluate a breast cancer case. Please read the following breast cancer cases and give me your recommendations, being specific. Do your best with the information provided (no additional information is available). | Your reply should be structured in the following format:
Case summary: Summarize the salient features of the case
Neoadjuvant therapy: Is neoadjuvant therapy indicated? If yes, what neoadjuvant therapy should be used.
Surgery: Is surgery indicated here? Considering this case in particular, describe if the surgical p... | For this case, is neoadjuvant therapy indicated? If yes, what specific neoadjuvant therapy should be used? Case: 59-year old woman goes to surgery. 2-mm grade 2 invasive ductal carcinoma (IDC), ER negative, PR negative, HER2 negative. No nodes positive. Had mastectomy. | For this case, what surgical approach is indicated? What specific pathology findings should I watch for? Case: 59-year old woman goes to surgery. 2-mm grade 2 invasive ductal carcinoma (IDC), ER negative, PR negative, HER2 negative. No nodes positive. Had mastectomy. | After surgery, what adjuvant therapy should be initiated for this case? Be specific about medications and sequence. Case: 59-year old woman goes to surgery. 2-mm grade 2 invasive ductal carcinoma (IDC), ER negative, PR negative, HER2 negative. No nodes positive. Had mastectomy. | Based on NCCN guidelines, does this patient meet criteria for genetic testing? What about their family? Case: 59-year old woman goes to surgery. 2-mm grade 2 invasive ductal carcinoma (IDC), ER negative, PR negative, HER2 negative. No nodes positive. Had mastectomy. | What psychosocial support and counseling would you recommend for this patient? Case: 59-year old woman goes to surgery. 2-mm grade 2 invasive ductal carcinoma (IDC), ER negative, PR negative, HER2 negative. No nodes positive. Had mastectomy. |
20 | naive | 42 | ER-/PR-/HER2- | Newly diagnosed | Small tumor (T1), no nodes involved | 42 year old woman, premenopausal, grade 3 invasive ductal carcinoma (IDC). Tumor size is 1.5 cm and Triple negative (ER negative, PR negative and HER2 negative) breast cancer. Nodes negative. | Surgery first, then adjuvant chemo (AC -> T) | You are a helpful medical assistant, and I am a breast cancer specialist using this tool to help me evaluate a breast cancer case. Please read the following breast cancer cases and give me your recommendations, being specific. Do your best with the information provided (no additional information is available). | Your reply should be structured in the following format:
Case summary: Summarize the salient features of the case
Neoadjuvant therapy: Is neoadjuvant therapy indicated? If yes, what neoadjuvant therapy should be used.
Surgery: Is surgery indicated here? Considering this case in particular, describe if the surgical p... | For this case, is neoadjuvant therapy indicated? If yes, what specific neoadjuvant therapy should be used? Case: 42 year old woman, premenopausal, grade 3 invasive ductal carcinoma (IDC). Tumor size is 1.5 cm and Triple negative (ER negative, PR negative and HER2 negative) breast cancer. Nodes negative. | For this case, what surgical approach is indicated? What specific pathology findings should I watch for? Case: 42 year old woman, premenopausal, grade 3 invasive ductal carcinoma (IDC). Tumor size is 1.5 cm and Triple negative (ER negative, PR negative and HER2 negative) breast cancer. Nodes negative. | After surgery, what adjuvant therapy should be initiated for this case? Be specific about medications and sequence. Case: 42 year old woman, premenopausal, grade 3 invasive ductal carcinoma (IDC). Tumor size is 1.5 cm and Triple negative (ER negative, PR negative and HER2 negative) breast cancer. Nodes negative. | Based on NCCN guidelines, does this patient meet criteria for genetic testing? What about their family? Case: 42 year old woman, premenopausal, grade 3 invasive ductal carcinoma (IDC). Tumor size is 1.5 cm and Triple negative (ER negative, PR negative and HER2 negative) breast cancer. Nodes negative. | What psychosocial support and counseling would you recommend for this patient? Case: 42 year old woman, premenopausal, grade 3 invasive ductal carcinoma (IDC). Tumor size is 1.5 cm and Triple negative (ER negative, PR negative and HER2 negative) breast cancer. Nodes negative. |
21 | naive | 65 | ER+/PR+/HER2- | Newly diagnosed | Small tumor (T1), no nodal involvement, invasive lobular | 65 year old woman, postmenopausal. 1.2 cm invasive lobular cancer. ER positive, PR positive, HER2 negative. 0/3 nodes are positive. | Lumpectomy. Radiation. Started on aromatase inhibitors. | You are a helpful medical assistant, and I am a breast cancer specialist using this tool to help me evaluate a breast cancer case. Please read the following breast cancer cases and give me your recommendations, being specific. Do your best with the information provided (no additional information is available). | Your reply should be structured in the following format:
Case summary: Summarize the salient features of the case
Neoadjuvant therapy: Is neoadjuvant therapy indicated? If yes, what neoadjuvant therapy should be used.
Surgery: Is surgery indicated here? Considering this case in particular, describe if the surgical p... | For this case, is neoadjuvant therapy indicated? If yes, what specific neoadjuvant therapy should be used? Case: 65 year old woman, postmenopausal. 1.2 cm invasive lobular cancer. ER positive, PR positive, HER2 negative. 0/3 nodes are positive. | For this case, what surgical approach is indicated? What specific pathology findings should I watch for? Case: 65 year old woman, postmenopausal. 1.2 cm invasive lobular cancer. ER positive, PR positive, HER2 negative. 0/3 nodes are positive. | After surgery, what adjuvant therapy should be initiated for this case? Be specific about medications and sequence. Case: 65 year old woman, postmenopausal. 1.2 cm invasive lobular cancer. ER positive, PR positive, HER2 negative. 0/3 nodes are positive. | Based on NCCN guidelines, does this patient meet criteria for genetic testing? What about their family? Case: 65 year old woman, postmenopausal. 1.2 cm invasive lobular cancer. ER positive, PR positive, HER2 negative. 0/3 nodes are positive. | What psychosocial support and counseling would you recommend for this patient? Case: 65 year old woman, postmenopausal. 1.2 cm invasive lobular cancer. ER positive, PR positive, HER2 negative. 0/3 nodes are positive. |
22 | naive | 48 | ER+/PR+/HER2- | Newly diagnosed | Small tumor (T1), nodal involvement with extra nodal extension | 48 years old woman. 1.7 cm grade 1 invasive ductal carcinoma (IDC). Premenopausal. ER positive (> 90%), PR positive (> 90%), HER2 negative. Ki-67 of 7%, had 2/7 nodes positive, with extra nodal extension. MammaPrint came back as low risk. | Taxotere + cyclophosphamide chemotherapy, followed by radiation and endocrine therapy. | You are a helpful medical assistant, and I am a breast cancer specialist using this tool to help me evaluate a breast cancer case. Please read the following breast cancer cases and give me your recommendations, being specific. Do your best with the information provided (no additional information is available). | Your reply should be structured in the following format:
Case summary: Summarize the salient features of the case
Neoadjuvant therapy: Is neoadjuvant therapy indicated? If yes, what neoadjuvant therapy should be used.
Surgery: Is surgery indicated here? Considering this case in particular, describe if the surgical p... | For this case, is neoadjuvant therapy indicated? If yes, what specific neoadjuvant therapy should be used? Case: 48 years old woman. 1.7 cm grade 1 invasive ductal carcinoma (IDC). Premenopausal. ER positive (> 90%), PR positive (> 90%), HER2 negative. Ki-67 of 7%, had 2/7 nodes positive, with extra nodal extension. Ma... | For this case, what surgical approach is indicated? What specific pathology findings should I watch for? Case: 48 years old woman. 1.7 cm grade 1 invasive ductal carcinoma (IDC). Premenopausal. ER positive (> 90%), PR positive (> 90%), HER2 negative. Ki-67 of 7%, had 2/7 nodes positive, with extra nodal extension. Mamm... | After surgery, what adjuvant therapy should be initiated for this case? Be specific about medications and sequence. Case: 48 years old woman. 1.7 cm grade 1 invasive ductal carcinoma (IDC). Premenopausal. ER positive (> 90%), PR positive (> 90%), HER2 negative. Ki-67 of 7%, had 2/7 nodes positive, with extra nodal exte... | Based on NCCN guidelines, does this patient meet criteria for genetic testing? What about their family? Case: 48 years old woman. 1.7 cm grade 1 invasive ductal carcinoma (IDC). Premenopausal. ER positive (> 90%), PR positive (> 90%), HER2 negative. Ki-67 of 7%, had 2/7 nodes positive, with extra nodal extension. Mamma... | What psychosocial support and counseling would you recommend for this patient? Case: 48 years old woman. 1.7 cm grade 1 invasive ductal carcinoma (IDC). Premenopausal. ER positive (> 90%), PR positive (> 90%), HER2 negative. Ki-67 of 7%, had 2/7 nodes positive, with extra nodal extension. MammaPrint came back as low ri... |
23 | naive | 42 | null | null | High risk surveillance | 42 year old woman. No personal history of breast cancer. Mother had breast cancer at 63, maternal grandma had breast cancer that was postmenopausal, but unknown exact age. Maternal aunt had esophageal cancer 60. Maternal uncle had prostate cancer. Maternal cousin with testicular cancer in his 20s. Genetic testing was n... | Surveillance every 6 months, alternating ultrasound + mammogram with breast MRI | You are a helpful medical assistant, and I am a breast cancer specialist using this tool to help me evaluate a breast cancer case. Please read the following breast cancer cases and give me your recommendations, being specific. Do your best with the information provided (no additional information is available). | Your reply should be structured in the following format:
Case summary: Summarize the salient features of the case
Neoadjuvant therapy: Is neoadjuvant therapy indicated? If yes, what neoadjuvant therapy should be used.
Surgery: Is surgery indicated here? Considering this case in particular, describe if the surgical p... | For this case, is neoadjuvant therapy indicated? If yes, what specific neoadjuvant therapy should be used? Case: 42 year old woman. No personal history of breast cancer. Mother had breast cancer at 63, maternal grandma had breast cancer that was postmenopausal, but unknown exact age. Maternal aunt had esophageal cancer... | For this case, what surgical approach is indicated? What specific pathology findings should I watch for? Case: 42 year old woman. No personal history of breast cancer. Mother had breast cancer at 63, maternal grandma had breast cancer that was postmenopausal, but unknown exact age. Maternal aunt had esophageal cancer 6... | After surgery, what adjuvant therapy should be initiated for this case? Be specific about medications and sequence. Case: 42 year old woman. No personal history of breast cancer. Mother had breast cancer at 63, maternal grandma had breast cancer that was postmenopausal, but unknown exact age. Maternal aunt had esophage... | Based on NCCN guidelines, does this patient meet criteria for genetic testing? What about their family? Case: 42 year old woman. No personal history of breast cancer. Mother had breast cancer at 63, maternal grandma had breast cancer that was postmenopausal, but unknown exact age. Maternal aunt had esophageal cancer 60... | What psychosocial support and counseling would you recommend for this patient? Case: 42 year old woman. No personal history of breast cancer. Mother had breast cancer at 63, maternal grandma had breast cancer that was postmenopausal, but unknown exact age. Maternal aunt had esophageal cancer 60. Maternal uncle had pros... |
24 | naive | 91 | ER+/PR-/HER2- | Newly diagnosed | Small tumor (T1), Geriatric oncology, no nodal involvement, post lumpectomy | 91-year old woman. Had a lumpectomy for a 2.5 cm, grade 3 invasive ductal carcinoma (IDC). ER positive (90%), PR 1%, HER2 neg. Ki-67 of 72%. No lymph nodes positive. | Complete radiation therapy. Then, exemestane. | You are a helpful medical assistant, and I am a breast cancer specialist using this tool to help me evaluate a breast cancer case. Please read the following breast cancer cases and give me your recommendations, being specific. Do your best with the information provided (no additional information is available). | Your reply should be structured in the following format:
Case summary: Summarize the salient features of the case
Neoadjuvant therapy: Is neoadjuvant therapy indicated? If yes, what neoadjuvant therapy should be used.
Surgery: Is surgery indicated here? Considering this case in particular, describe if the surgical p... | For this case, is neoadjuvant therapy indicated? If yes, what specific neoadjuvant therapy should be used? Case: 91-year old woman. Had a lumpectomy for a 2.5 cm, grade 3 invasive ductal carcinoma (IDC). ER positive (90%), PR 1%, HER2 neg. Ki-67 of 72%. No lymph nodes positive. | For this case, what surgical approach is indicated? What specific pathology findings should I watch for? Case: 91-year old woman. Had a lumpectomy for a 2.5 cm, grade 3 invasive ductal carcinoma (IDC). ER positive (90%), PR 1%, HER2 neg. Ki-67 of 72%. No lymph nodes positive. | After surgery, what adjuvant therapy should be initiated for this case? Be specific about medications and sequence. Case: 91-year old woman. Had a lumpectomy for a 2.5 cm, grade 3 invasive ductal carcinoma (IDC). ER positive (90%), PR 1%, HER2 neg. Ki-67 of 72%. No lymph nodes positive. | Based on NCCN guidelines, does this patient meet criteria for genetic testing? What about their family? Case: 91-year old woman. Had a lumpectomy for a 2.5 cm, grade 3 invasive ductal carcinoma (IDC). ER positive (90%), PR 1%, HER2 neg. Ki-67 of 72%. No lymph nodes positive. | What psychosocial support and counseling would you recommend for this patient? Case: 91-year old woman. Had a lumpectomy for a 2.5 cm, grade 3 invasive ductal carcinoma (IDC). ER positive (90%), PR 1%, HER2 neg. Ki-67 of 72%. No lymph nodes positive. |
25 | naive | 55 | ER+/PR-/HER2+ | Newly diagnosed | Large tumor (T2), nodal involvement on left side | 55 year old woman had 4.4 cm left breast mass and a left axillary LN on diagnosis. Had a biopsy of the breast mass and the LN were positive for grade 3 invasive ductal carcinoma (IDC). ER positive (8/8), PR negative (0/8) and HER2 positive. | Neoadjuvant tx, HP + chemo, and then she had surgery, attained a pathological complete response. Adjuvant HP, radiation and tamoxifen. | You are a helpful medical assistant, and I am a breast cancer specialist using this tool to help me evaluate a breast cancer case. Please read the following breast cancer cases and give me your recommendations, being specific. Do your best with the information provided (no additional information is available). | Your reply should be structured in the following format:
Case summary: Summarize the salient features of the case
Neoadjuvant therapy: Is neoadjuvant therapy indicated? If yes, what neoadjuvant therapy should be used.
Surgery: Is surgery indicated here? Considering this case in particular, describe if the surgical p... | For this case, is neoadjuvant therapy indicated? If yes, what specific neoadjuvant therapy should be used? Case: 55 year old woman had 4.4 cm left breast mass and a left axillary LN on diagnosis. Had a biopsy of the breast mass and the LN were positive for grade 3 invasive ductal carcinoma (IDC). ER positive (8/8), PR ... | For this case, what surgical approach is indicated? What specific pathology findings should I watch for? Case: 55 year old woman had 4.4 cm left breast mass and a left axillary LN on diagnosis. Had a biopsy of the breast mass and the LN were positive for grade 3 invasive ductal carcinoma (IDC). ER positive (8/8), PR ne... | After surgery, what adjuvant therapy should be initiated for this case? Be specific about medications and sequence. Case: 55 year old woman had 4.4 cm left breast mass and a left axillary LN on diagnosis. Had a biopsy of the breast mass and the LN were positive for grade 3 invasive ductal carcinoma (IDC). ER positive (... | Based on NCCN guidelines, does this patient meet criteria for genetic testing? What about their family? Case: 55 year old woman had 4.4 cm left breast mass and a left axillary LN on diagnosis. Had a biopsy of the breast mass and the LN were positive for grade 3 invasive ductal carcinoma (IDC). ER positive (8/8), PR neg... | What psychosocial support and counseling would you recommend for this patient? Case: 55 year old woman had 4.4 cm left breast mass and a left axillary LN on diagnosis. Had a biopsy of the breast mass and the LN were positive for grade 3 invasive ductal carcinoma (IDC). ER positive (8/8), PR negative (0/8) and HER2 posi... |
26 | naive | 65 | null | Newly diagnosed | Satellite lesions, sentinel lymph nodes with isolated tumor cells | 65 year old woman, went for lumpectomy. Four foci of grade 1 invasive ductal carcinoma (IDC): 1.3 cm, 1.1 cm, 5 mm, 4 mm. 1 out of 2 sentinel lymph node biopsy (SLN) with isolated tumor cells. OncotypeDx score of 12, low-risk. | Radiation followed by endocrine therapy. | You are a helpful medical assistant, and I am a breast cancer specialist using this tool to help me evaluate a breast cancer case. Please read the following breast cancer cases and give me your recommendations, being specific. Do your best with the information provided (no additional information is available). | Your reply should be structured in the following format:
Case summary: Summarize the salient features of the case
Neoadjuvant therapy: Is neoadjuvant therapy indicated? If yes, what neoadjuvant therapy should be used.
Surgery: Is surgery indicated here? Considering this case in particular, describe if the surgical p... | For this case, is neoadjuvant therapy indicated? If yes, what specific neoadjuvant therapy should be used? Case: 65 year old woman, went for lumpectomy. Four foci of grade 1 invasive ductal carcinoma (IDC): 1.3 cm, 1.1 cm, 5 mm, 4 mm. 1 out of 2 sentinel lymph node biopsy (SLN) with isolated tumor cells. OncotypeDx sco... | For this case, what surgical approach is indicated? What specific pathology findings should I watch for? Case: 65 year old woman, went for lumpectomy. Four foci of grade 1 invasive ductal carcinoma (IDC): 1.3 cm, 1.1 cm, 5 mm, 4 mm. 1 out of 2 sentinel lymph node biopsy (SLN) with isolated tumor cells. OncotypeDx score... | After surgery, what adjuvant therapy should be initiated for this case? Be specific about medications and sequence. Case: 65 year old woman, went for lumpectomy. Four foci of grade 1 invasive ductal carcinoma (IDC): 1.3 cm, 1.1 cm, 5 mm, 4 mm. 1 out of 2 sentinel lymph node biopsy (SLN) with isolated tumor cells. Oncot... | Based on NCCN guidelines, does this patient meet criteria for genetic testing? What about their family? Case: 65 year old woman, went for lumpectomy. Four foci of grade 1 invasive ductal carcinoma (IDC): 1.3 cm, 1.1 cm, 5 mm, 4 mm. 1 out of 2 sentinel lymph node biopsy (SLN) with isolated tumor cells. OncotypeDx score ... | What psychosocial support and counseling would you recommend for this patient? Case: 65 year old woman, went for lumpectomy. Four foci of grade 1 invasive ductal carcinoma (IDC): 1.3 cm, 1.1 cm, 5 mm, 4 mm. 1 out of 2 sentinel lymph node biopsy (SLN) with isolated tumor cells. OncotypeDx score of 12, low-risk. |
27 | naive | 65 | ER-/PR-/HER2- | Newly diagnosed | Very small tumor (T1), low Ki-67 | 65 year old woman. 8-mm right breast cancer. Grade 2 invasive ductal carcinoma (IDC). Triple negative (ER negative, PR negative and HER2 negative) breast cancer. Ki67 of 20%. | Upfront surgery. Depending on the pathology report, we will decide on chemotherapy or not. | You are a helpful medical assistant, and I am a breast cancer specialist using this tool to help me evaluate a breast cancer case. Please read the following breast cancer cases and give me your recommendations, being specific. Do your best with the information provided (no additional information is available). | Your reply should be structured in the following format:
Case summary: Summarize the salient features of the case
Neoadjuvant therapy: Is neoadjuvant therapy indicated? If yes, what neoadjuvant therapy should be used.
Surgery: Is surgery indicated here? Considering this case in particular, describe if the surgical p... | For this case, is neoadjuvant therapy indicated? If yes, what specific neoadjuvant therapy should be used? Case: 65 year old woman. 8-mm right breast cancer. Grade 2 invasive ductal carcinoma (IDC). Triple negative (ER negative, PR negative and HER2 negative) breast cancer. Ki67 of 20%. | For this case, what surgical approach is indicated? What specific pathology findings should I watch for? Case: 65 year old woman. 8-mm right breast cancer. Grade 2 invasive ductal carcinoma (IDC). Triple negative (ER negative, PR negative and HER2 negative) breast cancer. Ki67 of 20%. | After surgery, what adjuvant therapy should be initiated for this case? Be specific about medications and sequence. Case: 65 year old woman. 8-mm right breast cancer. Grade 2 invasive ductal carcinoma (IDC). Triple negative (ER negative, PR negative and HER2 negative) breast cancer. Ki67 of 20%. | Based on NCCN guidelines, does this patient meet criteria for genetic testing? What about their family? Case: 65 year old woman. 8-mm right breast cancer. Grade 2 invasive ductal carcinoma (IDC). Triple negative (ER negative, PR negative and HER2 negative) breast cancer. Ki67 of 20%. | What psychosocial support and counseling would you recommend for this patient? Case: 65 year old woman. 8-mm right breast cancer. Grade 2 invasive ductal carcinoma (IDC). Triple negative (ER negative, PR negative and HER2 negative) breast cancer. Ki67 of 20%. |
28 | naive | 33 | null | null | High risk surveillance and chemoprevention | 33 year old woman, she has a family history of paternal grandfather with prostate cancer and kidney cancer. She has had multiple biopsies on the left: One was benign, showed ductal hyperplasia and pseudoangiomatous stromal hyperplasia. Next biopsy showed Lobular carcinoma in situ (LCIS) and sclerosing papilloma and aty... | Started on tamoxifen as chemo-prevention. | You are a helpful medical assistant, and I am a breast cancer specialist using this tool to help me evaluate a breast cancer case. Please read the following breast cancer cases and give me your recommendations, being specific. Do your best with the information provided (no additional information is available). | Your reply should be structured in the following format:
Case summary: Summarize the salient features of the case
Neoadjuvant therapy: Is neoadjuvant therapy indicated? If yes, what neoadjuvant therapy should be used.
Surgery: Is surgery indicated here? Considering this case in particular, describe if the surgical p... | For this case, is neoadjuvant therapy indicated? If yes, what specific neoadjuvant therapy should be used? Case: 33 year old woman, she has a family history of paternal grandfather with prostate cancer and kidney cancer. She has had multiple biopsies on the left: One was benign, showed ductal hyperplasia and pseudoangi... | For this case, what surgical approach is indicated? What specific pathology findings should I watch for? Case: 33 year old woman, she has a family history of paternal grandfather with prostate cancer and kidney cancer. She has had multiple biopsies on the left: One was benign, showed ductal hyperplasia and pseudoangiom... | After surgery, what adjuvant therapy should be initiated for this case? Be specific about medications and sequence. Case: 33 year old woman, she has a family history of paternal grandfather with prostate cancer and kidney cancer. She has had multiple biopsies on the left: One was benign, showed ductal hyperplasia and p... | Based on NCCN guidelines, does this patient meet criteria for genetic testing? What about their family? Case: 33 year old woman, she has a family history of paternal grandfather with prostate cancer and kidney cancer. She has had multiple biopsies on the left: One was benign, showed ductal hyperplasia and pseudoangioma... | What psychosocial support and counseling would you recommend for this patient? Case: 33 year old woman, she has a family history of paternal grandfather with prostate cancer and kidney cancer. She has had multiple biopsies on the left: One was benign, showed ductal hyperplasia and pseudoangiomatous stromal hyperplasia.... |
29 | naive | 55 | null | Newly diagnosed | Small tumor (T1), post lumpectomy, no nodal involvement | 55 year old woman, went for a right lumpectomy for a 2.7 cm grade 1 invasive ductal carcinoma (IDC). No lymph nodes. OncotypeDX score of 29. | Adjuvant chemotherapy with TC x4. | You are a helpful medical assistant, and I am a breast cancer specialist using this tool to help me evaluate a breast cancer case. Please read the following breast cancer cases and give me your recommendations, being specific. Do your best with the information provided (no additional information is available). | Your reply should be structured in the following format:
Case summary: Summarize the salient features of the case
Neoadjuvant therapy: Is neoadjuvant therapy indicated? If yes, what neoadjuvant therapy should be used.
Surgery: Is surgery indicated here? Considering this case in particular, describe if the surgical p... | For this case, is neoadjuvant therapy indicated? If yes, what specific neoadjuvant therapy should be used? Case: 55 year old woman, went for a right lumpectomy for a 2.7 cm grade 1 invasive ductal carcinoma (IDC). No lymph nodes. OncotypeDX score of 29. | For this case, what surgical approach is indicated? What specific pathology findings should I watch for? Case: 55 year old woman, went for a right lumpectomy for a 2.7 cm grade 1 invasive ductal carcinoma (IDC). No lymph nodes. OncotypeDX score of 29. | After surgery, what adjuvant therapy should be initiated for this case? Be specific about medications and sequence. Case: 55 year old woman, went for a right lumpectomy for a 2.7 cm grade 1 invasive ductal carcinoma (IDC). No lymph nodes. OncotypeDX score of 29. | Based on NCCN guidelines, does this patient meet criteria for genetic testing? What about their family? Case: 55 year old woman, went for a right lumpectomy for a 2.7 cm grade 1 invasive ductal carcinoma (IDC). No lymph nodes. OncotypeDX score of 29. | What psychosocial support and counseling would you recommend for this patient? Case: 55 year old woman, went for a right lumpectomy for a 2.7 cm grade 1 invasive ductal carcinoma (IDC). No lymph nodes. OncotypeDX score of 29. |
30 | naive | 39 | ER+/PR-/HER2- | Newly diagnosed | Very large tumor (T3) Satellite lesions, R-axillary LAD, residual disease, neoadjuvant therapy, lymph node micrometastasis and extra-nodal extension | 39 year old woman, premenopausal. Had a right breast mass. At least 4 masses, the total span was 15 cm. Had right axillary lymphadenopathy. Biopsy of the masses and lymph node showed grade 2 invasive ductal carcinoma (IDC). ER positive (95%) PR 7%, HER2 negative. Received neoadjuvant AC for 4 cycles, weekly taxol for 1... | We would do radiation, followed by ovarian suppression plus aromatase inhibitor, plus verzinio and zometa. | You are a helpful medical assistant, and I am a breast cancer specialist using this tool to help me evaluate a breast cancer case. Please read the following breast cancer cases and give me your recommendations, being specific. Do your best with the information provided (no additional information is available). | Your reply should be structured in the following format:
Case summary: Summarize the salient features of the case
Neoadjuvant therapy: Is neoadjuvant therapy indicated? If yes, what neoadjuvant therapy should be used.
Surgery: Is surgery indicated here? Considering this case in particular, describe if the surgical p... | For this case, is neoadjuvant therapy indicated? If yes, what specific neoadjuvant therapy should be used? Case: 39 year old woman, premenopausal. Had a right breast mass. At least 4 masses, the total span was 15 cm. Had right axillary lymphadenopathy. Biopsy of the masses and lymph node showed grade 2 invasive ductal ... | For this case, what surgical approach is indicated? What specific pathology findings should I watch for? Case: 39 year old woman, premenopausal. Had a right breast mass. At least 4 masses, the total span was 15 cm. Had right axillary lymphadenopathy. Biopsy of the masses and lymph node showed grade 2 invasive ductal ca... | After surgery, what adjuvant therapy should be initiated for this case? Be specific about medications and sequence. Case: 39 year old woman, premenopausal. Had a right breast mass. At least 4 masses, the total span was 15 cm. Had right axillary lymphadenopathy. Biopsy of the masses and lymph node showed grade 2 invasiv... | Based on NCCN guidelines, does this patient meet criteria for genetic testing? What about their family? Case: 39 year old woman, premenopausal. Had a right breast mass. At least 4 masses, the total span was 15 cm. Had right axillary lymphadenopathy. Biopsy of the masses and lymph node showed grade 2 invasive ductal car... | What psychosocial support and counseling would you recommend for this patient? Case: 39 year old woman, premenopausal. Had a right breast mass. At least 4 masses, the total span was 15 cm. Had right axillary lymphadenopathy. Biopsy of the masses and lymph node showed grade 2 invasive ductal carcinoma (IDC). ER positive... |
31 | refractory | 61 | ER-/PR-/HER2- | Recurrent disease, refractory to multiple lines of treatment | KEYNOTE-522 trial, residual disease, metastasis to the bone, multiple lines of treatment, declining performance status, further disease progression (End of life care) | 61 year old woman, post-menopausal. Triple negative breast cancer (ER negative, PR negative, HER-2 negative). Treated with neoadjuvant KEYNOTE-522, mastectomy, Xeloda for residual disease, unfortunately developed metastatic disease to bone. Went on to receive 5 additional lines of chemotherapy. Progression of disease n... | Compassionate care, hospice. | You are a helpful medical assistant, and I am a breast cancer specialist using this tool to help me evaluate a breast cancer case. Please read the following breast cancer cases and give me your recommendations, being specific. Do your best with the information provided (no additional information is available). | Your reply should be structured in the following format:
Case summary: Summarize the salient features of the case
Neoadjuvant therapy: Is neoadjuvant therapy indicated? If yes, what neoadjuvant therapy should be used.
Surgery: Is surgery indicated here? Considering this case in particular, describe if the surgical p... | For this case, is neoadjuvant therapy indicated? If yes, what specific neoadjuvant therapy should be used? Case: 61 year old woman, post-menopausal. Triple negative breast cancer (ER negative, PR negative, HER-2 negative). Treated with neoadjuvant KEYNOTE-522, mastectomy, Xeloda for residual disease, unfortunately deve... | For this case, what surgical approach is indicated? What specific pathology findings should I watch for? Case: 61 year old woman, post-menopausal. Triple negative breast cancer (ER negative, PR negative, HER-2 negative). Treated with neoadjuvant KEYNOTE-522, mastectomy, Xeloda for residual disease, unfortunately develo... | After surgery, what adjuvant therapy should be initiated for this case? Be specific about medications and sequence. Case: 61 year old woman, post-menopausal. Triple negative breast cancer (ER negative, PR negative, HER-2 negative). Treated with neoadjuvant KEYNOTE-522, mastectomy, Xeloda for residual disease, unfortuna... | Based on NCCN guidelines, does this patient meet criteria for genetic testing? What about their family? Case: 61 year old woman, post-menopausal. Triple negative breast cancer (ER negative, PR negative, HER-2 negative). Treated with neoadjuvant KEYNOTE-522, mastectomy, Xeloda for residual disease, unfortunately develop... | What psychosocial support and counseling would you recommend for this patient? Case: 61 year old woman, post-menopausal. Triple negative breast cancer (ER negative, PR negative, HER-2 negative). Treated with neoadjuvant KEYNOTE-522, mastectomy, Xeloda for residual disease, unfortunately developed metastatic disease to ... |
32 | refractory | 75 | ER-/PR-/HER2+ | Recurrent disease, refractory to multiple lines of treatment | Full course of treatment, multi-organ metastasis, brain radiation, progression in brain after radiation (End of life care) | 75 year old woman, post-menopausal. Stage III HER-2 positive breast cancer. Treated with neoadjuvant + surgery + rads. Adjuvant anti-HER2 therapy for 1 year. Developed metastasis to liver, bones, lung and brain. Radiation to the first brain metastasis, systemic therapy with TDM1, and had control of disease for 1 year. ... | Compassionate care, hospice. Alternatively, she can get some benefit from CNS-active therapies such as fam-trastuzumab deruxtecan, or capecitabine/trastuzumab/tucatinib. | You are a helpful medical assistant, and I am a breast cancer specialist using this tool to help me evaluate a breast cancer case. Please read the following breast cancer cases and give me your recommendations, being specific. Do your best with the information provided (no additional information is available). | Your reply should be structured in the following format:
Case summary: Summarize the salient features of the case
Neoadjuvant therapy: Is neoadjuvant therapy indicated? If yes, what neoadjuvant therapy should be used.
Surgery: Is surgery indicated here? Considering this case in particular, describe if the surgical p... | For this case, is neoadjuvant therapy indicated? If yes, what specific neoadjuvant therapy should be used? Case: 75 year old woman, post-menopausal. Stage III HER-2 positive breast cancer. Treated with neoadjuvant + surgery + rads. Adjuvant anti-HER2 therapy for 1 year. Developed metastasis to liver, bones, lung and br... | For this case, what surgical approach is indicated? What specific pathology findings should I watch for? Case: 75 year old woman, post-menopausal. Stage III HER-2 positive breast cancer. Treated with neoadjuvant + surgery + rads. Adjuvant anti-HER2 therapy for 1 year. Developed metastasis to liver, bones, lung and brai... | After surgery, what adjuvant therapy should be initiated for this case? Be specific about medications and sequence. Case: 75 year old woman, post-menopausal. Stage III HER-2 positive breast cancer. Treated with neoadjuvant + surgery + rads. Adjuvant anti-HER2 therapy for 1 year. Developed metastasis to liver, bones, lu... | Based on NCCN guidelines, does this patient meet criteria for genetic testing? What about their family? Case: 75 year old woman, post-menopausal. Stage III HER-2 positive breast cancer. Treated with neoadjuvant + surgery + rads. Adjuvant anti-HER2 therapy for 1 year. Developed metastasis to liver, bones, lung and brain... | What psychosocial support and counseling would you recommend for this patient? Case: 75 year old woman, post-menopausal. Stage III HER-2 positive breast cancer. Treated with neoadjuvant + surgery + rads. Adjuvant anti-HER2 therapy for 1 year. Developed metastasis to liver, bones, lung and brain. Radiation to the first ... |
33 | refractory | 50 | ER+/PR+/HER2- | Upfront metastatic disease | Axillary lymph node involvement, metastasis to bone and liver | 50 year old woman, pre-menopausal. Noted to have right palpable breast mass and lymph node in axilla. Core biopsy: Grade III invasive ductal carcinoma (IDC), ER positive, HER2 positive, Ki67 of 50%. Staging CT and bone scan show metastatic disease in bone and liver. | Chemo (Docetaxel-HP per the CLEOPATRA trial) + dual anti-HER2 frontline. | You are a helpful medical assistant, and I am a breast cancer specialist using this tool to help me evaluate a breast cancer case. Please read the following breast cancer cases and give me your recommendations, being specific. Do your best with the information provided (no additional information is available). | Your reply should be structured in the following format:
Case summary: Summarize the salient features of the case
Neoadjuvant therapy: Is neoadjuvant therapy indicated? If yes, what neoadjuvant therapy should be used.
Surgery: Is surgery indicated here? Considering this case in particular, describe if the surgical p... | For this case, is neoadjuvant therapy indicated? If yes, what specific neoadjuvant therapy should be used? Case: 50 year old woman, pre-menopausal. Noted to have right palpable breast mass and lymph node in axilla. Core biopsy: Grade III invasive ductal carcinoma (IDC), ER positive, HER2 positive, Ki67 of 50%. Staging ... | For this case, what surgical approach is indicated? What specific pathology findings should I watch for? Case: 50 year old woman, pre-menopausal. Noted to have right palpable breast mass and lymph node in axilla. Core biopsy: Grade III invasive ductal carcinoma (IDC), ER positive, HER2 positive, Ki67 of 50%. Staging CT... | After surgery, what adjuvant therapy should be initiated for this case? Be specific about medications and sequence. Case: 50 year old woman, pre-menopausal. Noted to have right palpable breast mass and lymph node in axilla. Core biopsy: Grade III invasive ductal carcinoma (IDC), ER positive, HER2 positive, Ki67 of 50%.... | Based on NCCN guidelines, does this patient meet criteria for genetic testing? What about their family? Case: 50 year old woman, pre-menopausal. Noted to have right palpable breast mass and lymph node in axilla. Core biopsy: Grade III invasive ductal carcinoma (IDC), ER positive, HER2 positive, Ki67 of 50%. Staging CT ... | What psychosocial support and counseling would you recommend for this patient? Case: 50 year old woman, pre-menopausal. Noted to have right palpable breast mass and lymph node in axilla. Core biopsy: Grade III invasive ductal carcinoma (IDC), ER positive, HER2 positive, Ki67 of 50%. Staging CT and bone scan show metast... |
34 | refractory | 40 | ER-/PR-/HER2- | Upfront metastatic disease | L-axillary lymph node involvement, metastatic disease to liver, PDL1-positive | 40 year old woman, pre-menopausal. Left palpable breast mass. Left axillary lymphadenopathy. Imaging and core biopsy came back with grade III invasive ductal carcinoma (IDC). ER negative, PR negative and HER2 negative. High Ki-67, 60%. Staging scans metastatic disease to liver. PDL1 positive. CPS of 12%, next line of t... | Chemo + immunotherapy. | You are a helpful medical assistant, and I am a breast cancer specialist using this tool to help me evaluate a breast cancer case. Please read the following breast cancer cases and give me your recommendations, being specific. Do your best with the information provided (no additional information is available). | Your reply should be structured in the following format:
Case summary: Summarize the salient features of the case
Neoadjuvant therapy: Is neoadjuvant therapy indicated? If yes, what neoadjuvant therapy should be used.
Surgery: Is surgery indicated here? Considering this case in particular, describe if the surgical p... | For this case, is neoadjuvant therapy indicated? If yes, what specific neoadjuvant therapy should be used? Case: 40 year old woman, pre-menopausal. Left palpable breast mass. Left axillary lymphadenopathy. Imaging and core biopsy came back with grade III invasive ductal carcinoma (IDC). ER negative, PR negative and HER... | For this case, what surgical approach is indicated? What specific pathology findings should I watch for? Case: 40 year old woman, pre-menopausal. Left palpable breast mass. Left axillary lymphadenopathy. Imaging and core biopsy came back with grade III invasive ductal carcinoma (IDC). ER negative, PR negative and HER2 ... | After surgery, what adjuvant therapy should be initiated for this case? Be specific about medications and sequence. Case: 40 year old woman, pre-menopausal. Left palpable breast mass. Left axillary lymphadenopathy. Imaging and core biopsy came back with grade III invasive ductal carcinoma (IDC). ER negative, PR negativ... | Based on NCCN guidelines, does this patient meet criteria for genetic testing? What about their family? Case: 40 year old woman, pre-menopausal. Left palpable breast mass. Left axillary lymphadenopathy. Imaging and core biopsy came back with grade III invasive ductal carcinoma (IDC). ER negative, PR negative and HER2 n... | What psychosocial support and counseling would you recommend for this patient? Case: 40 year old woman, pre-menopausal. Left palpable breast mass. Left axillary lymphadenopathy. Imaging and core biopsy came back with grade III invasive ductal carcinoma (IDC). ER negative, PR negative and HER2 negative. High Ki-67, 60%.... |
35 | refractory | 40 | ER+/HER2+ | Upfront metastatic disease | R-axillary lymph node involvement, high Ki-67, metastatic liver disease | 40 year old woman, pre-menopausal. Noted to have right palpable breast mass and lymphadenopathy in axilla. Core biopsy: Grade III invasive ductal carcinoma (IDC), ER positive, HER2 positive, Ki-67 of 60%. Staging CT and bone scan show metastatic disease in liver | Chemo + dual anti-HER2 frontline | You are a helpful medical assistant, and I am a breast cancer specialist using this tool to help me evaluate a breast cancer case. Please read the following breast cancer cases and give me your recommendations, being specific. Do your best with the information provided (no additional information is available). | Your reply should be structured in the following format:
Case summary: Summarize the salient features of the case
Neoadjuvant therapy: Is neoadjuvant therapy indicated? If yes, what neoadjuvant therapy should be used.
Surgery: Is surgery indicated here? Considering this case in particular, describe if the surgical p... | For this case, is neoadjuvant therapy indicated? If yes, what specific neoadjuvant therapy should be used? Case: 40 year old woman, pre-menopausal. Noted to have right palpable breast mass and lymphadenopathy in axilla. Core biopsy: Grade III invasive ductal carcinoma (IDC), ER positive, HER2 positive, Ki-67 of 60%. St... | For this case, what surgical approach is indicated? What specific pathology findings should I watch for? Case: 40 year old woman, pre-menopausal. Noted to have right palpable breast mass and lymphadenopathy in axilla. Core biopsy: Grade III invasive ductal carcinoma (IDC), ER positive, HER2 positive, Ki-67 of 60%. Stag... | After surgery, what adjuvant therapy should be initiated for this case? Be specific about medications and sequence. Case: 40 year old woman, pre-menopausal. Noted to have right palpable breast mass and lymphadenopathy in axilla. Core biopsy: Grade III invasive ductal carcinoma (IDC), ER positive, HER2 positive, Ki-67 o... | Based on NCCN guidelines, does this patient meet criteria for genetic testing? What about their family? Case: 40 year old woman, pre-menopausal. Noted to have right palpable breast mass and lymphadenopathy in axilla. Core biopsy: Grade III invasive ductal carcinoma (IDC), ER positive, HER2 positive, Ki-67 of 60%. Stagi... | What psychosocial support and counseling would you recommend for this patient? Case: 40 year old woman, pre-menopausal. Noted to have right palpable breast mass and lymphadenopathy in axilla. Core biopsy: Grade III invasive ductal carcinoma (IDC), ER positive, HER2 positive, Ki-67 of 60%. Staging CT and bone scan show ... |
36 | refractory | 40 | ER+/HER2- | Upfront metastatic disease | R-axillary lymph node involvement, metastatic liver disease | 40 year old woman, pre-menopausal. Noted to have right palpable breast mass and lymphadenopathy in axilla. Core biopsy: Grade III invasive ductal carcinoma (IDC), ER positive, HER2 negative Ki-67 of 40%. Staging CT and bone scan show metastatic disease in liver | CDK4/6 + aromatase inhibitor and ovarian suppression. | You are a helpful medical assistant, and I am a breast cancer specialist using this tool to help me evaluate a breast cancer case. Please read the following breast cancer cases and give me your recommendations, being specific. Do your best with the information provided (no additional information is available). | Your reply should be structured in the following format:
Case summary: Summarize the salient features of the case
Neoadjuvant therapy: Is neoadjuvant therapy indicated? If yes, what neoadjuvant therapy should be used.
Surgery: Is surgery indicated here? Considering this case in particular, describe if the surgical p... | For this case, is neoadjuvant therapy indicated? If yes, what specific neoadjuvant therapy should be used? Case: 40 year old woman, pre-menopausal. Noted to have right palpable breast mass and lymphadenopathy in axilla. Core biopsy: Grade III invasive ductal carcinoma (IDC), ER positive, HER2 negative Ki-67 of 40%. Sta... | For this case, what surgical approach is indicated? What specific pathology findings should I watch for? Case: 40 year old woman, pre-menopausal. Noted to have right palpable breast mass and lymphadenopathy in axilla. Core biopsy: Grade III invasive ductal carcinoma (IDC), ER positive, HER2 negative Ki-67 of 40%. Stagi... | After surgery, what adjuvant therapy should be initiated for this case? Be specific about medications and sequence. Case: 40 year old woman, pre-menopausal. Noted to have right palpable breast mass and lymphadenopathy in axilla. Core biopsy: Grade III invasive ductal carcinoma (IDC), ER positive, HER2 negative Ki-67 of... | Based on NCCN guidelines, does this patient meet criteria for genetic testing? What about their family? Case: 40 year old woman, pre-menopausal. Noted to have right palpable breast mass and lymphadenopathy in axilla. Core biopsy: Grade III invasive ductal carcinoma (IDC), ER positive, HER2 negative Ki-67 of 40%. Stagin... | What psychosocial support and counseling would you recommend for this patient? Case: 40 year old woman, pre-menopausal. Noted to have right palpable breast mass and lymphadenopathy in axilla. Core biopsy: Grade III invasive ductal carcinoma (IDC), ER positive, HER2 negative Ki-67 of 40%. Staging CT and bone scan show m... |
37 | refractory | 85 | ER-/PR-/HER2- | Upfront metastatic disease | Cardiac comorbidities, geriatric oncology, left axillary involvement, metastatic lung and liver disease, PDL1 positive | 85 year old woman, post-menopausal, DM, A-fib, HF. Left palpable breast mass. LN left axillary. Imaging and core biopsy came back with grade III invasive ductal carcinoma (IDC). Triple negative breast cancer (ER negative, PR negative, HER-2 negative). High Ki-67, 50%. Staging scans metastatic disease to liver and lungs... | Single-agent gemcitabine, add Keytruda | You are a helpful medical assistant, and I am a breast cancer specialist using this tool to help me evaluate a breast cancer case. Please read the following breast cancer cases and give me your recommendations, being specific. Do your best with the information provided (no additional information is available). | Your reply should be structured in the following format:
Case summary: Summarize the salient features of the case
Neoadjuvant therapy: Is neoadjuvant therapy indicated? If yes, what neoadjuvant therapy should be used.
Surgery: Is surgery indicated here? Considering this case in particular, describe if the surgical p... | For this case, is neoadjuvant therapy indicated? If yes, what specific neoadjuvant therapy should be used? Case: 85 year old woman, post-menopausal, DM, A-fib, HF. Left palpable breast mass. LN left axillary. Imaging and core biopsy came back with grade III invasive ductal carcinoma (IDC). Triple negative breast cancer... | For this case, what surgical approach is indicated? What specific pathology findings should I watch for? Case: 85 year old woman, post-menopausal, DM, A-fib, HF. Left palpable breast mass. LN left axillary. Imaging and core biopsy came back with grade III invasive ductal carcinoma (IDC). Triple negative breast cancer (... | After surgery, what adjuvant therapy should be initiated for this case? Be specific about medications and sequence. Case: 85 year old woman, post-menopausal, DM, A-fib, HF. Left palpable breast mass. LN left axillary. Imaging and core biopsy came back with grade III invasive ductal carcinoma (IDC). Triple negative brea... | Based on NCCN guidelines, does this patient meet criteria for genetic testing? What about their family? Case: 85 year old woman, post-menopausal, DM, A-fib, HF. Left palpable breast mass. LN left axillary. Imaging and core biopsy came back with grade III invasive ductal carcinoma (IDC). Triple negative breast cancer (E... | What psychosocial support and counseling would you recommend for this patient? Case: 85 year old woman, post-menopausal, DM, A-fib, HF. Left palpable breast mass. LN left axillary. Imaging and core biopsy came back with grade III invasive ductal carcinoma (IDC). Triple negative breast cancer (ER negative, PR negative, ... |
38 | refractory | 85 | ER-/PR-/HER2- | Upfront metastatic disease | Cardiac comorbidities, geriatric oncology, left axillary involvement, metastatic lung and liver disease, PDL1 negative | 85 year old woman, post-menopausal, DM, A-fib, HF. Left palpable breast mass. Left axillary lymphadenopathy. Imaging and core biopsy came back with grade III invasive ductal carcinoma (IDC). Triple negative breast cancer (ER negative, PR negative, HER-2 negative). High Ki-67, 50%. Staging scans metastatic disease to li... | Single-agent gemcitabine | You are a helpful medical assistant, and I am a breast cancer specialist using this tool to help me evaluate a breast cancer case. Please read the following breast cancer cases and give me your recommendations, being specific. Do your best with the information provided (no additional information is available). | Your reply should be structured in the following format:
Case summary: Summarize the salient features of the case
Neoadjuvant therapy: Is neoadjuvant therapy indicated? If yes, what neoadjuvant therapy should be used.
Surgery: Is surgery indicated here? Considering this case in particular, describe if the surgical p... | For this case, is neoadjuvant therapy indicated? If yes, what specific neoadjuvant therapy should be used? Case: 85 year old woman, post-menopausal, DM, A-fib, HF. Left palpable breast mass. Left axillary lymphadenopathy. Imaging and core biopsy came back with grade III invasive ductal carcinoma (IDC). Triple negative ... | For this case, what surgical approach is indicated? What specific pathology findings should I watch for? Case: 85 year old woman, post-menopausal, DM, A-fib, HF. Left palpable breast mass. Left axillary lymphadenopathy. Imaging and core biopsy came back with grade III invasive ductal carcinoma (IDC). Triple negative br... | After surgery, what adjuvant therapy should be initiated for this case? Be specific about medications and sequence. Case: 85 year old woman, post-menopausal, DM, A-fib, HF. Left palpable breast mass. Left axillary lymphadenopathy. Imaging and core biopsy came back with grade III invasive ductal carcinoma (IDC). Triple ... | Based on NCCN guidelines, does this patient meet criteria for genetic testing? What about their family? Case: 85 year old woman, post-menopausal, DM, A-fib, HF. Left palpable breast mass. Left axillary lymphadenopathy. Imaging and core biopsy came back with grade III invasive ductal carcinoma (IDC). Triple negative bre... | What psychosocial support and counseling would you recommend for this patient? Case: 85 year old woman, post-menopausal, DM, A-fib, HF. Left palpable breast mass. Left axillary lymphadenopathy. Imaging and core biopsy came back with grade III invasive ductal carcinoma (IDC). Triple negative breast cancer (ER negative, ... |
39 | refractory | 38 | ER+/PR+/HER2- | Recurrent disease after mastectomy | Male breast cancer, post treatment recurrence in mastectomy bed, radiation treatment and recurrence again to the bone | 38 year old male, obese. Presented with R-sided breast mass. Underwent imaging, biopsy shows grade II invasive ductal carcinoma (IDC). ER and PR positive, HER2 negative. Ki-67 20%. Received neoadjuvant chemo. Mastectomy, had sentinel lymph node (SLN) biopsy. Residual carcinoma. Had radiation post-mastectomy. Had recurr... | Endocrine therapy + CDK 4/6 inhibitor. | You are a helpful medical assistant, and I am a breast cancer specialist using this tool to help me evaluate a breast cancer case. Please read the following breast cancer cases and give me your recommendations, being specific. Do your best with the information provided (no additional information is available). | Your reply should be structured in the following format:
Case summary: Summarize the salient features of the case
Neoadjuvant therapy: Is neoadjuvant therapy indicated? If yes, what neoadjuvant therapy should be used.
Surgery: Is surgery indicated here? Considering this case in particular, describe if the surgical p... | For this case, is neoadjuvant therapy indicated? If yes, what specific neoadjuvant therapy should be used? Case: 38 year old male, obese. Presented with R-sided breast mass. Underwent imaging, biopsy shows grade II invasive ductal carcinoma (IDC). ER and PR positive, HER2 negative. Ki-67 20%. Received neoadjuvant chemo... | For this case, what surgical approach is indicated? What specific pathology findings should I watch for? Case: 38 year old male, obese. Presented with R-sided breast mass. Underwent imaging, biopsy shows grade II invasive ductal carcinoma (IDC). ER and PR positive, HER2 negative. Ki-67 20%. Received neoadjuvant chemo. ... | After surgery, what adjuvant therapy should be initiated for this case? Be specific about medications and sequence. Case: 38 year old male, obese. Presented with R-sided breast mass. Underwent imaging, biopsy shows grade II invasive ductal carcinoma (IDC). ER and PR positive, HER2 negative. Ki-67 20%. Received neoadjuv... | Based on NCCN guidelines, does this patient meet criteria for genetic testing? What about their family? Case: 38 year old male, obese. Presented with R-sided breast mass. Underwent imaging, biopsy shows grade II invasive ductal carcinoma (IDC). ER and PR positive, HER2 negative. Ki-67 20%. Received neoadjuvant chemo. M... | What psychosocial support and counseling would you recommend for this patient? Case: 38 year old male, obese. Presented with R-sided breast mass. Underwent imaging, biopsy shows grade II invasive ductal carcinoma (IDC). ER and PR positive, HER2 negative. Ki-67 20%. Received neoadjuvant chemo. Mastectomy, had sentinel l... |
40 | refractory | 58 | ER+/PR+/HER2- | Post-mastectomy | Male breast cancer, obese patient, Small tumor (T2), nodal involvement, post-mastectomy | 58 year old male, obese. Presented with R-sided breast mass. Underwent imaging, biopsy shows grade II invasive ductal carcinoma (IDC), ER and PR positive, HER2 negative. Ki-67 20%. 3 cm tumor. 3 nodes positive. Neoadjuvant chemo. Mastectomy, SLN biopsy positive. No residual cancer. | Endocrine therapy (Tamoxifen) and radiation. Can also consider adjuvant abemaciclib. | You are a helpful medical assistant, and I am a breast cancer specialist using this tool to help me evaluate a breast cancer case. Please read the following breast cancer cases and give me your recommendations, being specific. Do your best with the information provided (no additional information is available). | Your reply should be structured in the following format:
Case summary: Summarize the salient features of the case
Neoadjuvant therapy: Is neoadjuvant therapy indicated? If yes, what neoadjuvant therapy should be used.
Surgery: Is surgery indicated here? Considering this case in particular, describe if the surgical p... | For this case, is neoadjuvant therapy indicated? If yes, what specific neoadjuvant therapy should be used? Case: 58 year old male, obese. Presented with R-sided breast mass. Underwent imaging, biopsy shows grade II invasive ductal carcinoma (IDC), ER and PR positive, HER2 negative. Ki-67 20%. 3 cm tumor. 3 nodes positi... | For this case, what surgical approach is indicated? What specific pathology findings should I watch for? Case: 58 year old male, obese. Presented with R-sided breast mass. Underwent imaging, biopsy shows grade II invasive ductal carcinoma (IDC), ER and PR positive, HER2 negative. Ki-67 20%. 3 cm tumor. 3 nodes positive... | After surgery, what adjuvant therapy should be initiated for this case? Be specific about medications and sequence. Case: 58 year old male, obese. Presented with R-sided breast mass. Underwent imaging, biopsy shows grade II invasive ductal carcinoma (IDC), ER and PR positive, HER2 negative. Ki-67 20%. 3 cm tumor. 3 nod... | Based on NCCN guidelines, does this patient meet criteria for genetic testing? What about their family? Case: 58 year old male, obese. Presented with R-sided breast mass. Underwent imaging, biopsy shows grade II invasive ductal carcinoma (IDC), ER and PR positive, HER2 negative. Ki-67 20%. 3 cm tumor. 3 nodes positive.... | What psychosocial support and counseling would you recommend for this patient? Case: 58 year old male, obese. Presented with R-sided breast mass. Underwent imaging, biopsy shows grade II invasive ductal carcinoma (IDC), ER and PR positive, HER2 negative. Ki-67 20%. 3 cm tumor. 3 nodes positive. Neoadjuvant chemo. Maste... |
41 | refractory | 61 | ER+/PR+/HER2+ | Recurrent disease | Previously treated with lumpectomy + radiation, on hormone therapy, spinal and liver metastasis | 61 year old, post-menopausal female with prior history of ER positive, PR positive, HER-2 negative, node negative, involving right breast s/p lumpectomy. Got radiation four years ago, and taking anastrazole. Presenting to the ER with mid back pain, CT chest/abdomen/pelvis and MRI spine show metastatic disease with thre... | Switch to fulvestrant | You are a helpful medical assistant, and I am a breast cancer specialist using this tool to help me evaluate a breast cancer case. Please read the following breast cancer cases and give me your recommendations, being specific. Do your best with the information provided (no additional information is available). | Your reply should be structured in the following format:
Case summary: Summarize the salient features of the case
Neoadjuvant therapy: Is neoadjuvant therapy indicated? If yes, what neoadjuvant therapy should be used.
Surgery: Is surgery indicated here? Considering this case in particular, describe if the surgical p... | For this case, is neoadjuvant therapy indicated? If yes, what specific neoadjuvant therapy should be used? Case: 61 year old, post-menopausal female with prior history of ER positive, PR positive, HER-2 negative, node negative, involving right breast s/p lumpectomy. Got radiation four years ago, and taking anastrazole.... | For this case, what surgical approach is indicated? What specific pathology findings should I watch for? Case: 61 year old, post-menopausal female with prior history of ER positive, PR positive, HER-2 negative, node negative, involving right breast s/p lumpectomy. Got radiation four years ago, and taking anastrazole. P... | After surgery, what adjuvant therapy should be initiated for this case? Be specific about medications and sequence. Case: 61 year old, post-menopausal female with prior history of ER positive, PR positive, HER-2 negative, node negative, involving right breast s/p lumpectomy. Got radiation four years ago, and taking ana... | Based on NCCN guidelines, does this patient meet criteria for genetic testing? What about their family? Case: 61 year old, post-menopausal female with prior history of ER positive, PR positive, HER-2 negative, node negative, involving right breast s/p lumpectomy. Got radiation four years ago, and taking anastrazole. Pr... | What psychosocial support and counseling would you recommend for this patient? Case: 61 year old, post-menopausal female with prior history of ER positive, PR positive, HER-2 negative, node negative, involving right breast s/p lumpectomy. Got radiation four years ago, and taking anastrazole. Presenting to the ER with m... |
42 | refractory | 65 | ER+/PR+/HER2- | Progression of disease on therapy | On treatment, new lesions noted in liver, ESR-1 mutation | 65 year old, post-menopausal female with history of metastatic hormone positive (ER positive, PR positive, HER2 negative) breast cancer with bone involvement, is currently receiving anastrazole and verzinio. Repeat staging scans show new liver metastasis. NGS shows ESR-1 mutation. | Change to faslodex and verzinio. Alternatively, test for PIK3CA mutation. Use alpelisib if positive. | You are a helpful medical assistant, and I am a breast cancer specialist using this tool to help me evaluate a breast cancer case. Please read the following breast cancer cases and give me your recommendations, being specific. Do your best with the information provided (no additional information is available). | Your reply should be structured in the following format:
Case summary: Summarize the salient features of the case
Neoadjuvant therapy: Is neoadjuvant therapy indicated? If yes, what neoadjuvant therapy should be used.
Surgery: Is surgery indicated here? Considering this case in particular, describe if the surgical p... | For this case, is neoadjuvant therapy indicated? If yes, what specific neoadjuvant therapy should be used? Case: 65 year old, post-menopausal female with history of metastatic hormone positive (ER positive, PR positive, HER2 negative) breast cancer with bone involvement, is currently receiving anastrazole and verzinio.... | For this case, what surgical approach is indicated? What specific pathology findings should I watch for? Case: 65 year old, post-menopausal female with history of metastatic hormone positive (ER positive, PR positive, HER2 negative) breast cancer with bone involvement, is currently receiving anastrazole and verzinio. R... | After surgery, what adjuvant therapy should be initiated for this case? Be specific about medications and sequence. Case: 65 year old, post-menopausal female with history of metastatic hormone positive (ER positive, PR positive, HER2 negative) breast cancer with bone involvement, is currently receiving anastrazole and ... | Based on NCCN guidelines, does this patient meet criteria for genetic testing? What about their family? Case: 65 year old, post-menopausal female with history of metastatic hormone positive (ER positive, PR positive, HER2 negative) breast cancer with bone involvement, is currently receiving anastrazole and verzinio. Re... | What psychosocial support and counseling would you recommend for this patient? Case: 65 year old, post-menopausal female with history of metastatic hormone positive (ER positive, PR positive, HER2 negative) breast cancer with bone involvement, is currently receiving anastrazole and verzinio. Repeat staging scans show n... |
43 | refractory | 59 | ER+/PR+/HER2- | Progression of disease on therapy | On ribociclib, ESR-1 mutation, metastasis to bone and liver, changed therapy and now metastasis to lung | 59 year old, post-menopausal female with history of metastatic hormone positive (ER positive, PR positive, HER2 negative) breast cancer with bone and liver involvement. Had POD on anastrazole and ribociclib. Next generation sequencing (NGS) shows ESR-1 mutation. She was changed to fulvestrant and ribociclib. Now presen... | Continue faslodex + Everolimus or Enhertu | You are a helpful medical assistant, and I am a breast cancer specialist using this tool to help me evaluate a breast cancer case. Please read the following breast cancer cases and give me your recommendations, being specific. Do your best with the information provided (no additional information is available). | Your reply should be structured in the following format:
Case summary: Summarize the salient features of the case
Neoadjuvant therapy: Is neoadjuvant therapy indicated? If yes, what neoadjuvant therapy should be used.
Surgery: Is surgery indicated here? Considering this case in particular, describe if the surgical p... | For this case, is neoadjuvant therapy indicated? If yes, what specific neoadjuvant therapy should be used? Case: 59 year old, post-menopausal female with history of metastatic hormone positive (ER positive, PR positive, HER2 negative) breast cancer with bone and liver involvement. Had POD on anastrazole and ribociclib.... | For this case, what surgical approach is indicated? What specific pathology findings should I watch for? Case: 59 year old, post-menopausal female with history of metastatic hormone positive (ER positive, PR positive, HER2 negative) breast cancer with bone and liver involvement. Had POD on anastrazole and ribociclib. N... | After surgery, what adjuvant therapy should be initiated for this case? Be specific about medications and sequence. Case: 59 year old, post-menopausal female with history of metastatic hormone positive (ER positive, PR positive, HER2 negative) breast cancer with bone and liver involvement. Had POD on anastrazole and ri... | Based on NCCN guidelines, does this patient meet criteria for genetic testing? What about their family? Case: 59 year old, post-menopausal female with history of metastatic hormone positive (ER positive, PR positive, HER2 negative) breast cancer with bone and liver involvement. Had POD on anastrazole and ribociclib. Ne... | What psychosocial support and counseling would you recommend for this patient? Case: 59 year old, post-menopausal female with history of metastatic hormone positive (ER positive, PR positive, HER2 negative) breast cancer with bone and liver involvement. Had POD on anastrazole and ribociclib. Next generation sequencing ... |
44 | refractory | 63 | ER+/PR+/HER2- | Progression of disease on therapy | On treatment, progression to liver and biliary involvement, changed therapy and still had new metastasis to lung | 63 year old, post-menopausal female with history of metastatic hormone positive (ER positive, PR positive, HER2 negative) breast cancer with bone involvement. Had progression of disease (POD) on first line anastrazole and ribociclib. Next generation sequencing (NGS) shows ESR-1 mutation. She was changed to fulvestrant ... | Change to elacestrant. Continue xgeva for bone disease. | You are a helpful medical assistant, and I am a breast cancer specialist using this tool to help me evaluate a breast cancer case. Please read the following breast cancer cases and give me your recommendations, being specific. Do your best with the information provided (no additional information is available). | Your reply should be structured in the following format:
Case summary: Summarize the salient features of the case
Neoadjuvant therapy: Is neoadjuvant therapy indicated? If yes, what neoadjuvant therapy should be used.
Surgery: Is surgery indicated here? Considering this case in particular, describe if the surgical p... | For this case, is neoadjuvant therapy indicated? If yes, what specific neoadjuvant therapy should be used? Case: 63 year old, post-menopausal female with history of metastatic hormone positive (ER positive, PR positive, HER2 negative) breast cancer with bone involvement. Had progression of disease (POD) on first line a... | For this case, what surgical approach is indicated? What specific pathology findings should I watch for? Case: 63 year old, post-menopausal female with history of metastatic hormone positive (ER positive, PR positive, HER2 negative) breast cancer with bone involvement. Had progression of disease (POD) on first line ana... | After surgery, what adjuvant therapy should be initiated for this case? Be specific about medications and sequence. Case: 63 year old, post-menopausal female with history of metastatic hormone positive (ER positive, PR positive, HER2 negative) breast cancer with bone involvement. Had progression of disease (POD) on fir... | Based on NCCN guidelines, does this patient meet criteria for genetic testing? What about their family? Case: 63 year old, post-menopausal female with history of metastatic hormone positive (ER positive, PR positive, HER2 negative) breast cancer with bone involvement. Had progression of disease (POD) on first line anas... | What psychosocial support and counseling would you recommend for this patient? Case: 63 year old, post-menopausal female with history of metastatic hormone positive (ER positive, PR positive, HER2 negative) breast cancer with bone involvement. Had progression of disease (POD) on first line anastrazole and ribociclib. N... |
45 | refractory | 55 | ER+/PR+/HER2- | Progression after mastectomy and radiation | Initial presentation with node involvement, received mastectomy, on treatment, recurrent disease in bone and liver with same molecular features | 55 year old woman, post menopausal, with history of prior hormone positive (ER positive, PR positive), HER2 negative right breast cancer. Stage II on presentation with 3-4 nodes positive. Received right mastectomy and radiation. OncotypeDX score 29 and received adjuvant chemotherapy. Received verzinio and anastrazole f... | Change to enhertu and xgeva, continue anastrazole | You are a helpful medical assistant, and I am a breast cancer specialist using this tool to help me evaluate a breast cancer case. Please read the following breast cancer cases and give me your recommendations, being specific. Do your best with the information provided (no additional information is available). | Your reply should be structured in the following format:
Case summary: Summarize the salient features of the case
Neoadjuvant therapy: Is neoadjuvant therapy indicated? If yes, what neoadjuvant therapy should be used.
Surgery: Is surgery indicated here? Considering this case in particular, describe if the surgical p... | For this case, is neoadjuvant therapy indicated? If yes, what specific neoadjuvant therapy should be used? Case: 55 year old woman, post menopausal, with history of prior hormone positive (ER positive, PR positive), HER2 negative right breast cancer. Stage II on presentation with 3-4 nodes positive. Received right mast... | For this case, what surgical approach is indicated? What specific pathology findings should I watch for? Case: 55 year old woman, post menopausal, with history of prior hormone positive (ER positive, PR positive), HER2 negative right breast cancer. Stage II on presentation with 3-4 nodes positive. Received right mastec... | After surgery, what adjuvant therapy should be initiated for this case? Be specific about medications and sequence. Case: 55 year old woman, post menopausal, with history of prior hormone positive (ER positive, PR positive), HER2 negative right breast cancer. Stage II on presentation with 3-4 nodes positive. Received r... | Based on NCCN guidelines, does this patient meet criteria for genetic testing? What about their family? Case: 55 year old woman, post menopausal, with history of prior hormone positive (ER positive, PR positive), HER2 negative right breast cancer. Stage II on presentation with 3-4 nodes positive. Received right mastect... | What psychosocial support and counseling would you recommend for this patient? Case: 55 year old woman, post menopausal, with history of prior hormone positive (ER positive, PR positive), HER2 negative right breast cancer. Stage II on presentation with 3-4 nodes positive. Received right mastectomy and radiation. Oncoty... |
46 | refractory | 63 | ER+/PR+/HER2- | Progression of disease on therapy | Upfront metastasis with bone involvement, progressed on therapy, now with PIK3CA mutation | 63 year old, post-menopausal female with history of metastatic hormone positive breast cancer with bone involvement. Had progression of disease on first line anastrazole and ribociclib. NGS shows PIK3CA mutation. | Change to Alpelisib and Fulvestrant. Continue Xgeva for bone disease | You are a helpful medical assistant, and I am a breast cancer specialist using this tool to help me evaluate a breast cancer case. Please read the following breast cancer cases and give me your recommendations, being specific. Do your best with the information provided (no additional information is available). | Your reply should be structured in the following format:
Case summary: Summarize the salient features of the case
Neoadjuvant therapy: Is neoadjuvant therapy indicated? If yes, what neoadjuvant therapy should be used.
Surgery: Is surgery indicated here? Considering this case in particular, describe if the surgical p... | For this case, is neoadjuvant therapy indicated? If yes, what specific neoadjuvant therapy should be used? Case: 63 year old, post-menopausal female with history of metastatic hormone positive breast cancer with bone involvement. Had progression of disease on first line anastrazole and ribociclib. NGS shows PIK3CA muta... | For this case, what surgical approach is indicated? What specific pathology findings should I watch for? Case: 63 year old, post-menopausal female with history of metastatic hormone positive breast cancer with bone involvement. Had progression of disease on first line anastrazole and ribociclib. NGS shows PIK3CA mutati... | After surgery, what adjuvant therapy should be initiated for this case? Be specific about medications and sequence. Case: 63 year old, post-menopausal female with history of metastatic hormone positive breast cancer with bone involvement. Had progression of disease on first line anastrazole and ribociclib. NGS shows PI... | Based on NCCN guidelines, does this patient meet criteria for genetic testing? What about their family? Case: 63 year old, post-menopausal female with history of metastatic hormone positive breast cancer with bone involvement. Had progression of disease on first line anastrazole and ribociclib. NGS shows PIK3CA mutatio... | What psychosocial support and counseling would you recommend for this patient? Case: 63 year old, post-menopausal female with history of metastatic hormone positive breast cancer with bone involvement. Had progression of disease on first line anastrazole and ribociclib. NGS shows PIK3CA mutation. |
End of preview. Expand in Data Studio
YAML Metadata Warning:The task_ids "text-classification" is not in the official list: acceptability-classification, entity-linking-classification, fact-checking, intent-classification, language-identification, multi-class-classification, multi-label-classification, multi-input-text-classification, natural-language-inference, semantic-similarity-classification, sentiment-classification, topic-classification, semantic-similarity-scoring, sentiment-scoring, sentiment-analysis, hate-speech-detection, text-scoring, named-entity-recognition, part-of-speech, parsing, lemmatization, word-sense-disambiguation, coreference-resolution, extractive-qa, open-domain-qa, closed-domain-qa, news-articles-summarization, news-articles-headline-generation, dialogue-modeling, dialogue-generation, conversational, language-modeling, text-simplification, explanation-generation, abstractive-qa, open-domain-abstractive-qa, closed-domain-qa, open-book-qa, closed-book-qa, text2text-generation, slot-filling, masked-language-modeling, keyword-spotting, speaker-identification, audio-intent-classification, audio-emotion-recognition, audio-language-identification, multi-label-image-classification, multi-class-image-classification, face-detection, vehicle-detection, instance-segmentation, semantic-segmentation, panoptic-segmentation, image-captioning, image-inpainting, image-colorization, super-resolution, grasping, task-planning, tabular-multi-class-classification, tabular-multi-label-classification, tabular-single-column-regression, rdf-to-text, multiple-choice-qa, multiple-choice-coreference-resolution, document-retrieval, utterance-retrieval, entity-linking-retrieval, fact-checking-retrieval, univariate-time-series-forecasting, multivariate-time-series-forecasting, visual-question-answering, document-question-answering, pose-estimation
YAML Metadata Warning:The task_ids "medical-diagnosis" is not in the official list: acceptability-classification, entity-linking-classification, fact-checking, intent-classification, language-identification, multi-class-classification, multi-label-classification, multi-input-text-classification, natural-language-inference, semantic-similarity-classification, sentiment-classification, topic-classification, semantic-similarity-scoring, sentiment-scoring, sentiment-analysis, hate-speech-detection, text-scoring, named-entity-recognition, part-of-speech, parsing, lemmatization, word-sense-disambiguation, coreference-resolution, extractive-qa, open-domain-qa, closed-domain-qa, news-articles-summarization, news-articles-headline-generation, dialogue-modeling, dialogue-generation, conversational, language-modeling, text-simplification, explanation-generation, abstractive-qa, open-domain-abstractive-qa, closed-domain-qa, open-book-qa, closed-book-qa, text2text-generation, slot-filling, masked-language-modeling, keyword-spotting, speaker-identification, audio-intent-classification, audio-emotion-recognition, audio-language-identification, multi-label-image-classification, multi-class-image-classification, face-detection, vehicle-detection, instance-segmentation, semantic-segmentation, panoptic-segmentation, image-captioning, image-inpainting, image-colorization, super-resolution, grasping, task-planning, tabular-multi-class-classification, tabular-multi-label-classification, tabular-single-column-regression, rdf-to-text, multiple-choice-qa, multiple-choice-coreference-resolution, document-retrieval, utterance-retrieval, entity-linking-retrieval, fact-checking-retrieval, univariate-time-series-forecasting, multivariate-time-series-forecasting, visual-question-answering, document-question-answering, pose-estimation
Oncology AMIE Dataset
Dataset Description
This dataset contains detailed clinical cases of breast cancer patients, including their age, molecular phenotype (ER/PR/HER2 status), treatment status, special considerations, and ground truth treatment recommendations. The cases are divided into treatment-naive and treatment-refractory categories.
Dataset Summary
A clinical dataset containing breast cancer cases with their descriptions, molecular phenotypes, and treatment recommendations. The dataset includes both treatment-naive and treatment-refractory cases, along with structured questions and system prompts for AI assistance.
Features
The dataset includes the following columns:
- id: Unique identifier for each case
- type: Whether the case is treatment-naive or treatment-refractory
- age: Patient age
- molecular_phenotype: ER/PR/HER2 status
- treatment_status: Current treatment status
- special_considerations: Additional clinical considerations
- description: Detailed case description
- ground_truth: Expert-provided treatment recommendation
- system_prompt: General instruction for AI assistance
- question_all: Complete case evaluation question with structured format
- question_neoadjuvant: Specific question about neoadjuvant therapy
- question_surgery: Specific question about surgical approach
- question_adjuvant: Specific question about adjuvant therapy
- question_genetic: Specific question about genetic testing
- question_support: Specific question about psychosocial support
Usage
This dataset can be used for:
- Training medical AI systems
- Clinical decision support development
- Medical education and training
- Research in oncology treatment protocols
Citation
If you use this dataset, please cite:
@misc{onc_amie_dataset,
title={Oncology AMIE Dataset},
author={Gallifant, Jack},
year={2024},
publisher={Hugging Face}
}
- Downloads last month
- 3