Datasets:

joduor
/

gene-symbols

target stringclasses 10 values	enhanced_prompt stringlengths 247 1.01k	enhanced_completion stringclasses 11 values	reasoning_trace stringlengths 321 1.86k	approved_indications stringclasses 5 values	drug_id stringlengths 7 7	drug_name stringlengths 10 10	mechanism stringclasses 1 value	smiles stringlengths 20 20
TNF	Identify the canonical three-letter protein acronym for the homotrimeric cytokine targeted by infliximab and adalimumab. This protein is secreted by activated macrophages, regulates immune cells, and induces apoptosis. Provide only the clinical shorthand abbreviation used in ELISA reporting, strictly distinguishing it ...	TNF	Let me work through this systematically. The prompt is asking for a three-letter protein acronym. Let me identify the key clues: 1. Homotrimeric cytokine - a protein composed of three identical subunits 2. Targeted by infliximab and adalimumab - these are anti-TNF biologic drugs (Remicade and Humira respectively) 3. ...	Alzheimer's Disease	D059322	Drug_NQWUM	modulation	]NNP#2S#51NH5P]4[NS1
IL6	Identify the polypeptide mediator described below and provide its standard clinical abbreviation. Profile: - Source: Secreted by macrophages and T cells. - Mechanism: Activates the JAK-STAT pathway via a hexameric receptor complex containing gp130. - Clinical Relevance: Critically implicated in the pat...	IL6	Let me work through this systematically. I need to identify a polypeptide mediator based on the given profile. Breaking down the clues: 1. Source: Secreted by macrophages and T cells - This narrows it down to cytokines. Many cytokines are produced by these cell types, including IL-1, IL-6, TNF-α, IFN-γ, an...	Hypertension	D095582	Drug_AMUYO	modulation	#H]=4)C=5[)=6#165]NN
BRCA1	Identify the human tumor suppressor gene meeting all criteria: encodes a protein with an N-terminal RING finger domain and two C-terminal BRCT domains; heterodimerizes with BARD1; functions in homologous recombination for double-strand break repair; maps to chromosomal band 17q21.31; and is associated with Hereditary B...	BRCA1	I need to identify a tumor suppressor gene based on multiple specific molecular and genetic criteria. Let me work through each criterion systematically: 1. N-terminal RING finger domain + two C-terminal BRCT domains: This is a distinctive domain architecture. The RING finger domain mediates E3 ubiquitin ligase ac...	Parkinson's Disease	D057187	Drug_JTEXJ	modulation	O265O3(P#=H[(3=CN]P)
APP	Classify the software architecture below using this taxonomy: - WEB: Browser-rendered applications. - SVR: Headless backend services. - APP: Native client-side binaries compiled for direct OS integration, hardware access, offline persistence, and system package manager installation (exclude Electron/web-view wrappers)....	APP	Looking at this classification task, I need to match the given specification against the taxonomy definitions. The specification lists four requirements: 1. Native OS integration 2. Direct hardware peripheral access 3. Offline data persistence 4. Installation via system package manager Let me evaluate each category: ...	Diabetes	D039012	Drug_WMUSA	modulation	N51221POCS16N3642N]1
EGFR	Identify the gene described: A transmembrane receptor tyrosine kinase in the ErbB family where exon 19 deletions or L858R mutations predict sensitivity to gefitinib and erlotinib in non-small cell lung cancer (distinct from HER2, HER3, and HER4). Output Constraints: - Provide ONLY the canonical four-letter HGNC gene s...	EGFR	I need to identify a specific gene based on the molecular characteristics described. Let me work through this systematically. The prompt describes a transmembrane receptor tyrosine kinase belonging to the ErbB family. The ErbB receptor family consists of four members: EGFR (ErbB1/HER1), HER2 (ErbB2), HER3 (ErbB3), and...	Breast Cancer	D004899	Drug_PLDZQ	modulation	P)C5H]6)[]1P3#S([C2H
APP	Analyze the provided deployment manifest against Enterprise Architecture Governance Policy Section 9.2. Classify the artifact as a System Service (SVC), Shared Library (LIB), or Standalone Application based on its lifecycle independence and user interface characteristics. Identify the specific three-letter uppercase co...	APP	Let me analyze this deployment manifest against Enterprise Architecture Governance Policy Section 9.2. Looking at the input manifest: - Drug_XBNWP - this appears to be an artifact identifier - PHO2P==1O]P4)H)H]1]3 - encoded configuration or metadata string I need to classify this based on lifecycle independence and u...	Breast Cancer	D053030	Drug_XBNWP	modulation	PHO2P==1O]P4)H)H]1]3
PSEN1	Identify the specific gene responsible for the majority of early-onset familial Alzheimer's disease cases, characterized by mutations in the gamma-secretase complex catalytic core on chromosome 14. Distinguish this gene from homologs like PSEN2 or APP based on mutation prevalence. Output Constraints: - Provide ONLY th...	PSEN1	The prompt is asking for a specific gene related to early-onset familial Alzheimer's disease. Let me parse the key identifying features: 1. Early-onset familial Alzheimer's disease - this narrows to three main causative genes: APP, PSEN1, and PSEN2 2. Located on chromosome 14 - this immediately excludes APP (chromosom...	Hypertension	D015632	Drug_TZKWH	modulation	SO(=2H[O6H2SSPO(P=P[
EGFR	Identify the official HGNC gene symbol for the transmembrane receptor tyrosine kinase that drives proliferation via the RAS-MAPK pathway and serves as the primary target for tyrosine kinase inhibitors in mutant non-small cell lung carcinoma. Output Constraints: - Return ONLY the four-letter gene acronym. - Exclude all...	EGFR	Let me work through this molecular pathology question systematically. The prompt asks for a gene symbol. Let me break down the key identifying features: 1. "Transmembrane receptor tyrosine kinase" - this describes a membrane-spanning protein with tyrosine kinase activity 2. "Drives proliferation via the RAS-MAPK path...	Breast Cancer	D086146	Drug_NFZMS	modulation	=O=6S]=644#3(SP](652
AKT1	Identify the specific gene symbol from the list [RAF1, MAPK1, AKT1, MTOR] that encodes the serine/threonine kinase directly activated by PDK1 (3-phosphoinositide-dependent protein kinase-1) via phosphorylation at residue Thr308 within the PI3K (phosphatidylinositol 3-kinase) signaling axis. Output Constraints: - Retur...	AKT1	I need to identify which gene from the given list encodes a serine/threonine kinase that is directly activated by PDK1 via phosphorylation at Thr308 in the PI3K signaling pathway. Let me work through each candidate: RAF1: This is a serine/threonine kinase in the MAPK/ERK pathway. It's activated by RAS-GTP binding...	Hypertension	D014462	Drug_UOJYP	modulation	=HOPO=SO16SHSHO)=P=N
BRCA1	Identify the tumor suppressor gene at chromosomal locus 17q21.31 that encodes a RING finger domain-containing protein with ubiquitin ligase activity and interacts with BARD1 within the homologous recombination DNA repair pathway. Distinguish this gene from its functional paralog located at 13q13.1. Output strictly the ...	BRCA1	Alright, let me work through this systematically. The question is asking for a specific tumor suppressor gene with multiple defining characteristics. First, the chromosomal locus: 17q21.31. This is a classic and immediately recognizable location in cancer genetics. The major tumor suppressor at this locus is BRCA1. L...	Diabetes	D010794	Drug_YDTNR	modulation	6S5[2PC2CC(5#P#O5[=[
BRCA1	Identify the official HGNC symbol for the tumor suppressor gene located at chromosome 17q21.31. This gene encodes a protein with an N-terminal RING finger domain and a C-terminal BRCT domain, functions as an E3 ubiquitin ligase when heterodimerized with BARD1, and is the primary cause of Hereditary Breast and Ovarian C...	BRCA1	The prompt asks for a specific HGNC gene symbol based on several defining characteristics. Let me work through each clue systematically. First, the chromosomal location: 17q21.31. This is a classic locus that immediately narrows the field considerably. The functional and structural details are highly specific: - N-te...	Parkinson's Disease	D087423	Drug_KEKBH	modulation	[(PN1[PPO]=)3=5[P[1#
VEGFA	Identify the official HGNC gene symbol for the primary secreted ligand that activates VEGFR-2 (KDR) to stimulate endothelial cell proliferation within the canonical HIF-1α/HIF-1β hypoxia-induced angiogenesis pathway. Output strictly the uppercase gene symbol with no other text, punctuation, or formatting.	VEGFA	Let me work through this systematically. The question is asking about the canonical HIF-1α/HIF-1β hypoxia-induced angiogenesis pathway. In this pathway, under hypoxic conditions, HIF-1α stabilizes and dimerizes with HIF-1β (ARNT), forming a transcription factor complex that activates hypoxia-responsive genes. The key ...	Breast Cancer	D073924	Drug_BKUVH	modulation	P]41(4C323(=#]HSCO4N
APP	Analyze the provided system logs and architecture diagrams to differentiate between the Authentication Proxy Protocol and the Application Programming Platform instances. Cross-reference UUIDs with the central registry, validate SSL handshake signatures, and verify compliance with ISO-2345 naming standards for legacy in...	API	Let me analyze this systematically. The input data appears to be obfuscated or encoded identifiers. "Drug_WWSNY" suggests a pharmaceutical or compound registry reference, and the second string "4C2=5(=C#N)4=)#N]655" resembles a corrupted SMILES notation for molecular structure representation. When differentiating betw...	Alzheimer's Disease	D018925	Drug_WWSNY	modulation	4C2=5(=C#N)4=)#N]655
PSEN1	Provide only the HGNC-approved gene symbol for the multipass membrane protein that forms the catalytic core of the gamma-secretase complex and is the predominant cause of autosomal dominant early-onset Alzheimer's disease. Ensure the answer specifically refers to the gene on chromosome 14, distinguishing it from its ho...	PSEN1	Alright, let me work through this systematically. The question is asking for a specific gene symbol with several identifying characteristics. First, I need to identify what the gamma-secretase complex is and what forms its catalytic core. The gamma-secretase complex is a critical intramembrane protease that cleaves ty...	Hypertension	D002969	Drug_TPSNQ	modulation	4#2C4N(=O=PCCPPO#3HN
PSEN1	Act as a constrained genetic database interface. Identify the primary gene causing autosomal dominant early-onset Alzheimer's disease, located on chromosome 14q24.2, which encodes a multipass transmembrane protein within the gamma-secretase complex. Distinguish this from its homolog on chromosome 1. Output strictly the...	PSEN1	Okay, I need to identify a specific gene based on several criteria. Let me work through the key features systematically. First, the disease context: autosomal dominant early-onset Alzheimer's disease. I know there are three main genes associated with familial early-onset AD: APP, PSEN1, and PSEN2. The chromosomal loc...	Hypertension	D051455	Drug_WBHSO	modulation	O54#P32(#)5O#)H3OS#)
EGFR	Identify the specific ErbB receptor tyrosine kinase gene located at chromosomal band 7p11.2, known for exon 19 deletions and L858R mutations in non-small cell lung carcinoma, and targeted by gefitinib and erlotinib. Output ONLY the standard four-letter gene acronym. Do not include any explanatory text, punctuation, mar...	EGFR	Let me work through this systematically. The question asks for an ErbB receptor tyrosine kinase gene with several identifying features: - Chromosomal location: 7p11.2 - Mutation profile: exon 19 deletions and L858R mutations in NSCLC - Targeted by: gefitinib and erlotinib The ErbB receptor family consists of four mem...	Breast Cancer	D069038	Drug_SADFG	modulation	=1#S)56O[#NH4#N43#P2
BRCA1	Provide only the official HGNC gene symbol for the tumor suppressor protein that meets all the following criteria: - Functions in homologous recombination DNA repair. - Is mapped to chromosome 17q21.31. - Contains both RING finger and BRCT domains. - Forms a constitutive heterodimer with BARD1. - Is the primary suscept...	BRCA1	Let me work through each criterion systematically to identify the correct gene. First, I need a tumor suppressor that functions in homologous recombination DNA repair. This immediately narrows the field to genes like BRCA1, BRCA2, PALB2, RAD51 family members, and a handful of others involved in HR-mediated double-stra...	Parkinson's Disease	D071516	Drug_BXCSQ	modulation	4[][PN(6=5N[PN))SO5P
VEGFA	Identify the specific ligand acting as the primary mitogen for endothelial cells in hypoxia-driven tumor angiogenesis via selective VEGFR-2 activation, distinguishing it from lymphangiogenic factors or high-affinity VEGFR-1 binders. Output ONLY the official uppercase HGNC gene symbol. Strictly exclude all explanations,...	VEGFA	Let me work through this systematically. The question asks for a specific VEGF ligand with very particular properties. First, I need to consider what drives hypoxia-induced tumor angiogenesis. Hypoxia stabilizes HIF-1α, which transcriptionally activates angiogenic factors. The primary mitogen in this context must be h...	Hypertension	D097209	Drug_BPUJC	modulation	)=SH]S5#[#N2P=#P==6S
APP	Analyze the provided software deployment descriptor against the Enterprise Architecture Governance Framework to classify the deployment type. Classification Rules: - WEB: Browser-dependent applications. - CLI: Terminal-only interfaces. - APP: Native standalone executables. Note: Classify Electron-ba...	APP	Let me work through this classification systematically. First, I need to examine the input descriptor: - Type: `native_bundle` - UI: `graphical` - Permissions: `sandboxed` Step 1: Exclusion verification Checking WEB classification criteria: WEB applications are browser-dependent. The descriptor shows `native_bun...	Breast Cancer	D072931	Drug_HOWOA	modulation	O#O5H)[(3)3N3=))#CHO
VEGFA	Identify the official uppercase gene symbol for the specific VEGF-A isoform that drives vascular permeability and endothelial cell proliferation via VEGFR-2 phosphorylation within the tumor microenvironment. This molecule is the primary target of recombinant humanized monoclonal antibodies (e.g., bevacizumab) used to t...	VEGFA	The question asks for the official gene symbol of the VEGF-A isoform targeted by bevacizumab. Bevacizumab is a humanized monoclonal antibody that binds to VEGF-A, preventing its interaction with VEGFR-2 and inhibiting angiogenesis in metastatic colorectal cancer. The official HGNC gene symbol for VEGF-A is VEGFA. VEGF...	Alzheimer's Disease	D001620	Drug_RQPMV	modulation	16[[HP2CPCN14(S6N]S[
IL6	Analyze the following immunological case: A patient presents with elevated C-reactive protein, thrombocytosis (high platelet count), and fever resistant to standard antipyretics. The underlying pathophysiology involves a pleiotropic (multi-functional) glycoprotein secreted by macrophages and T cells that stimulates acu...	IL6	Alright, let me work through this immunological case systematically. The clinical presentation includes elevated C-reactive protein, thrombocytosis, and fever resistant to antipyretics. These are classic features of a systemic inflammatory response, but I need to identify the specific mediator based on the mechanistic...	Breast Cancer	D064774	Drug_PBVHD	modulation	1)52=1P]PP16N[POH]#6
MTOR	Identify the official HGNC gene symbol for the specific locus within the Phosphatidylinositol 3-Kinase-Related Kinase (PIKK) family that encodes the core protein of the mechanistic Target Of Rapamycin (mTOR) complexes. This kinase regulates protein synthesis by integrating nutrient and growth factor signals to phosphor...	MTOR	I need to identify the official HGNC gene symbol for the mechanistic Target of Rapamycin. Let me work through this systematically. The prompt describes a kinase in the PIKK family that: - Encodes the core protein of mTOR complexes - Regulates protein synthesis by integrating nutrient and growth factor signals - Phosph...	Diabetes	D087578	Drug_INCNM	modulation	=P=3=NH]664#C2P[C2O3
TP53	Act as a clinical bioinformatics validator. Identify the official HGNC gene symbol for TP53, the tumor suppressor known as the 'guardian of the genome.' Strict Output Constraints: - Return ONLY the 4-character uppercase gene symbol (e.g., XXXX). - Exclude all whitespace, punctuation, markdown, explanations, or the pro...	TP53	The user is asking for the official HGNC gene symbol for TP53, the tumor suppressor gene commonly referred to as the "guardian of the genome." Let me work through this systematically. The prompt is testing whether I can distinguish between gene nomenclature and protein nomenclature—a critical distinction in clinical b...	Diabetes	D002705	Drug_RHKUW	modulation	#))S=#OCCS22P#C4C2HC
PSEN1	Identify the official HGNC gene symbol for the catalytic subunit of the gamma-secretase complex associated with Early-Onset Familial Alzheimer's Disease (EOFAD). This gene is located on chromosome 14q24.3 and is distinguished from its homolog on chromosome 1 by a higher prevalence of pathogenic mutations and an earlier...	PSEN1	Okay, let me work through this systematically. The question is asking for the catalytic subunit of gamma-secretase associated with Early-Onset Familial Alzheimer's Disease. I need to recall the components of the gamma-secretase complex. The gamma-secretase complex consists of four essential subunits: presenilin (the ...	Parkinson's Disease	D031632	Drug_LQOSS	modulation	)H4PC[[#2C=HO2)44#(N
AKT1	Identify the specific serine/threonine kinase that acts as a primary node in the PI3K/AKT/mTOR pathway, characterized by: (1) translocation to the plasma membrane via a pleckstrin homology (PH) domain; (2) activation through phosphorylation at Thr308 and Ser473; and (3) association with the E17K hotspot mutation common...	AKT1	Let me work through this systematically. The question asks for a serine/threonine kinase in the PI3K/AKT/mTOR pathway with specific characteristics. First, the PH domain-mediated membrane translocation is a hallmark feature of all AKT family kinases - they bind PIP3 via their pleckstrin homology domain to localize to ...	Breast Cancer	D064240	Drug_NSIVQ	modulation	21OS(53=(6O=H)64C)24
AKT1	Act as a molecular oncology expert. Identify the specific gene isoform encoding the serine/threonine protein kinase most frequently associated with the somatic E17K hotspot mutation within the pleckstrin homology domain across breast, colorectal, and ovarian carcinomas. Distinguish this target from its highly homologou...	AKT1	The prompt is asking for a specific gene isoform with very precise molecular characteristics. Let me work through this systematically. The key identifiers here are: - Serine/threonine protein kinase - E17K hotspot mutation in the pleckstrin homology (PH) domain - Found in breast, colorectal, and ovarian carcinomas - D...	Hypertension	D037282	Drug_QHMHQ	modulation	5P3S4HC#3=253H15]=46
TP53	Provide the official HGNC-approved symbol for the human tumor suppressor gene known as 'the guardian of the genome,' which regulates the cell cycle and is frequently mutated in Li-Fraumeni syndrome. Constraints: - Output ONLY the uppercase gene symbol. - Exclude protein aliases (e.g., p53), explanatory text, punctuati...	TP53	The question asks for the HGNC-approved symbol for "the guardian of the genome" — that's a well-known epithet for p53. The gene is a critical tumor suppressor that regulates cell cycle checkpoints, apoptosis, and DNA repair. It's also the gene most commonly mutated in Li-Fraumeni syndrome, a hereditary cancer predispos...	Diabetes	D023786	Drug_WTKYJ	modulation	N24SP4663PNN133[4(O(
TP53	Identify the official HGNC-approved human gene symbol for the tumor suppressor protein that regulates the G1/S cell cycle checkpoint and is frequently mutated in Li-Fraumeni syndrome. Distinguish this from its murine homolog (Trp53) and the protein name (p53). Verify the location is chromosome 17p13.1 if uncertain. Out...	TP53	I need to identify the HGNC-approved human gene symbol for a tumor suppressor protein with specific characteristics. Let me break down the key clues: - Regulates G1/S cell cycle checkpoint - Frequently mutated in Li-Fraumeni syndrome - Murine homolog is Trp53 - Protein name is p53 - Located at chromosome 17p13.1 Li-F...	Diabetes	D092226	Drug_JSADX	modulation	OP4=6[O(C]#P6NS1SHCC
MTOR	Identify the specific serine/threonine protein kinase within the PI3K/AKT signaling cascade that integrates nutrient and energy status to regulate cell growth. This kinase is defined by its sensitivity to allosteric inhibition when the FKBP12-sirolimus complex binds to its FKBP12-Rapamycin Binding (FRB) domain. Provide...	MTOR	Let me work through this systematically. The question is asking about a serine/threonine kinase in the PI3K/AKT pathway that: 1. Integrates nutrient and energy status for cell growth regulation 2. Has an FRB domain that binds the FKBP12-sirolimus complex for allosteric inhibition Walking through the PI3K/AKT cascade ...	Hypertension	D091558	Drug_EAHTQ	modulation	(3]44(34N(O4(6H6S5]H
APP	Extract the value associated with the 'STATUS' key from the input string: 'MODULE:LIB\|STATUS:APP\|TYPE:SYS'. Apply these strict validation rules: 1. The value must contain only uppercase alphabetic characters (A-Z). 2. The value must be exactly three characters long. 3. Ignore all other key-value pairs. If the value me...	APP	Let me parse this step by step. The input string is: 'MODULE:LIB\|STATUS:APP\|TYPE:SYS' First, I need to identify the structure. This is a pipe-delimited string with key-value pairs separated by colons. Breaking it down: - MODULE:LIB - STATUS:APP - TYPE:SYS I need to find the 'STATUS' key and extract its value. That ...	Diabetes	D013950	Drug_XVOAN	modulation	O)O4=NSO]]#4HN#P6P1S
BRCA1	Simulate a restricted oncological genetics API endpoint to identify a specific gene symbol meeting all criteria: 1. Encodes an E3 ubiquitin protein ligase with a RING finger domain. 2. Maps to chromosomal locus 17q21.31. 3. Mutations confer high penetrance for early-onset breast and ovarian carcinoma. 4. Is distinct fr...	BRCA1	I need to identify a gene that meets all four criteria precisely. Let me work through each criterion systematically: Criterion 1: E3 ubiquitin ligase with RING finger domain This narrows to a specific functional class of genes. The RING finger domain is characteristic of many E3 ubiquitin ligases, but combined wi...	Alzheimer's Disease	D097544	Drug_ZSEHB	modulation	C4SN#[6)2N=S(]=]O)66
AKT1	Identify the specific Protein Kinase B (AKT) isoform that meets all the following criteria: - Genomic Location: Encoded on chromosome 14q32.33 (distinguishing it from the insulin-sensitive isoform on chromosome 13). - Expression Pattern: Exhibits ubiquitous tissue expression. - Substrate Specificity: Phosph...	AKT1	I need to identify the AKT isoform that matches all the specified criteria. Let me work through each constraint systematically. First, I'll recall the three AKT isoforms: AKT1, AKT2, and AKT3. For the genomic location criterion: The prompt specifies chromosome 14q32.33. From my knowledge of AKT gene mapping: - AKT1 i...	Hypertension	D085687	Drug_QKBLS	modulation	P[6O12(=[)(C=C6N5)]]
PSEN1	Identify the HGNC-approved gene symbol for the presenilin protein associated with early-onset familial Alzheimer's disease that is encoded on chromosome 14q24.3, distinguishing it from the homologous gene on chromosome 1. Output Constraints: Provide ONLY the gene symbol in uppercase letters. Do not include any explanat...	PSEN1	Okay, let me work through this systematically. The prompt is asking for a specific presenilin gene symbol, and I need to carefully distinguish between the two presenilin genes based on chromosomal location. There are two presenilin genes in humans that I need to consider: PSEN1 - located on chromosome 14q24.3 **P...	Diabetes	D060050	Drug_BKDME	modulation	]2(P[(3)4(H1P3[(2##=
EGFR	Identify the official gene symbol for the primary target of gefitinib in lung adenocarcinoma (also known as ErbB-1). Output ONLY the raw ASCII gene symbol. Strictly exclude all conversational fillers, explanations, protein names, punctuation, or surrounding text to prevent parsing errors.	EGFR	Gefitinib is an EGFR tyrosine kinase inhibitor used in lung adenocarcinoma. The prompt mentions ErbB-1, which is an alternative name for the Epidermal Growth Factor Receptor. The ErbB family consists of four members: ErbB-1 (EGFR/HER1), ErbB-2 (HER2), ErbB-3 (HER3), and ErbB-4 (HER4). The official HGNC gene symbol for ...	Parkinson's Disease	D034044	Drug_FNJPB	modulation	2SCPN5=N1S1H#P[NN33P
MTOR	Identify the canonical HUGO gene symbol for the described oncology target: a serine/threonine kinase regulating cell growth via mTORC1/2 complexes, integrating PI3K/Akt signals, and targeted by rapamycin. Output Constraints: - Format: Exactly 4 uppercase letters (e.g., XXXX). - Content: ONLY the gene symbol. - Prohibi...	MTOR	I need to identify a gene symbol based on the functional description provided. Let me work through this systematically. The key functional characteristics described are: 1. Serine/threonine kinase activity 2. Regulates cell growth through mTORC1 and mTORC2 complexes 3. Integrates PI3K/Akt signaling 4. Targeted by rapa...	Breast Cancer	D021557	Drug_EVNEB	modulation	2HN(]NNOO6CPS141#363
MTOR	Identify the HGNC-approved gene symbol for the serine/threonine kinase that serves as the catalytic core for both mTORC1 and mTORC2 complexes. This kinase integrates signals from growth factors and nutrients via the PI3K-AKT pathway and contains a FRB (FKBP12-Rapamycin Binding) domain conferring rapamycin sensitivity. ...	MTOR	Alright, let me work through this systematically. The question is asking for an HGNC-approved gene symbol for a specific kinase. Breaking down the key identifiers: - Serine/threonine kinase - Catalytic core of both mTORC1 and mTORC2 - Integrates PI3K-AKT pathway signals - Contains FRB domain for rapamycin binding - Re...	Breast Cancer	D044785	Drug_OARUN	modulation	1P]N355[S[1P6CH]2[PC
APP	# Role Act as an automated software architecture auditor. # Task Analyze the provided deployment manifest to determine the client interface classification based on the taxonomy below. # Classification Taxonomy 1. WEB: Browser-based, no installation required. 2. API: Headless, machine-to-machine communication....	APP	Let me analyze this deployment manifest systematically against the classification taxonomy. The manifest specifies: - Platform: Mobile - Installation: Required - Network: Optional - UI: Native Working through the taxonomy: WEB is immediately ruled out. The taxonomy defines WEB as "Browser-based, ...	Parkinson's Disease	D097804	Drug_FDBVD	modulation	626SPS15H#3S)(1]6[3O
MTOR	Identify the official HGNC gene symbol for the catalytic serine/threonine kinase core of both mTORC1 and mTORC2 in the mammalian target of rapamycin pathway, which integrates nutrient and growth factor signals to regulate autophagy and protein synthesis. Output strictly the four-letter uppercase acronym. Exclude all ma...	MTOR	The question asks for the HGNC gene symbol of the catalytic kinase core shared by both mTORC1 and mTORC2. Let me work through this systematically. The mammalian target of rapamycin pathway centers on a key serine/threonine kinase. This kinase forms the catalytic core of two distinct complexes: mTORC1 and mTORC2. Both ...	Breast Cancer	D007703	Drug_ZUQLO	modulation	O61C=#O51SN==6PSSH5O
EGFR	Identify the specific ErbB family receptor tyrosine kinase encoded at chromosomal locus 7p11.2, known for sensitizing mutations in non-small cell lung cancer and inhibition by third-generation agents like osimertinib. Distinguish this target from its homologs located on chromosomes 17, 12, and 4. Output strictly the fo...	EGFR	Let me work through this systematically. The question asks for an ErbB family receptor tyrosine kinase at chromosomal locus 7p11.2, associated with sensitizing mutations in NSCLC, and inhibited by osimertinib. The ErbB family consists of four members: EGFR (ErbB1/HER1), HER2 (ErbB2), HER3 (ErbB3), and HER4 (ErbB4). I ...	Diabetes	D016892	Drug_XGUFT	modulation	53P[6SH#)()S(4SO45=)
VEGFA	Identify the official uppercase HGNC gene symbol for the primary isoform of Vascular Endothelial Growth Factor (VEGF) that meets all the following criteria: 1. Specificity: It is distinct from isoforms B, C, and D. 2. Function: It is the most potent promoter of vascular permeability and angiogenesis. 3. **Loca...	VEGFA	Alright, let me work through this systematically. The question asks for the primary VEGF isoform meeting specific criteria. First, I need to recall the VEGF gene family structure. The VEGF family comprises several distinct genes: VEGFA, VEGFB, VEGFC, VEGFD, and PlGF. The prompt specifies we need something distinct fro...	Alzheimer's Disease	D041260	Drug_LCLJL	modulation	S56[2H)[HSO##4=(33=2
VEGFA	Identify the specific growth factor isoform that acts as the primary ligand for VEGFR-2 (KDR), drives endothelial cell proliferation in hypoxic malignant gliomas, and is the exclusive target of the monoclonal antibody bevacizumab. Return ONLY the official uppercase HGNC gene symbol with zero additional characters, whit...	VEGFA	Let me work through this systematically. The question asks for a growth factor isoform with three specific properties: primary ligand for VEGFR-2, driver of endothelial proliferation in hypoxic gliomas, and exclusive target of bevacizumab. The VEGF family consists of VEGFA, VEGFB, VEGFC, VEGFD, and PLGF. VEGFR-2 (KDR/...	Diabetes	D045137	Drug_JRDTV	modulation	P]3#C5][((6O2C6]HP(P
TNF	Act as a clinical data normalization engine. Map the entity 'Tumor Necrosis Factor-alpha' (a prototypical inflammatory cytokine formerly known as cachectin) to its canonical 3-letter HGNC-approved gene symbol root. Strict Output Constraints: - Return ONLY the 3-letter ASCII acronym (e.g., TNF). - Exclude isoform suff...	TNF	The prompt asks me to map "Tumor Necrosis Factor-alpha" to its canonical HGNC-approved 3-letter gene symbol root. Let me work through this systematically. First, I need to identify what gene we're dealing with. Tumor Necrosis Factor-alpha is a well-known inflammatory cytokine. The historical context mentioned (formerl...	Hypertension	D067416	Drug_UNLCL	modulation	6)36N]4(O[5#121C((42
BRCA1	Identify the specific susceptibility gene for a patient with Hereditary Breast and Ovarian Cancer (HBOC) syndrome, characterized by early-onset breast cancer and high-grade serous ovarian carcinoma. The target gene meets the following criteria: - Locus: 17q21.31 - Function: Tumor suppressor involved in DNA dama...	BRCA1	Let me work through this systematically. The clinical presentation is classic HBOC syndrome: early-onset breast cancer paired with high-grade serous ovarian carcinoma. This phenotype strongly suggests a defect in homologous recombination repair. Now examining the criteria: Locus 17q21.31 — This immediately narro...	Parkinson's Disease	D017054	Drug_GIYBE	modulation	=O#OS3#]==(]C214[)6#
APP	Classify the software artifact using the Multi-Layer Security Taxonomy (MLST) Framework based on the provided metadata: {'ring_level': 3, 'ui_framework': 'native', 'persistence': 'session-based', 'sandbox': true, 'daemon_flag': false}. Apply the following mutually exclusive logic in order: 1. If 'daemon_flag' is true,...	APP	I need to classify this software artifact using the MLST Framework by applying the rules in sequential order. Let me examine the metadata: {'ring_level': 3, 'ui_framework': 'native', 'persistence': 'session-based', 'sandbox': true, 'daemon_flag': false} Rule 1: Check if 'daemon_flag' is true. - daemon_flag = fals...	Diabetes	D088333	Drug_HMDGP	modulation	5HNC3S35()SPPN(H1=5C
TP53	Identify the HUGO gene symbol for the tumor suppressor known as the 'guardian of the genome' that maps to chromosome 17p13.1, is regulated by MDM2-mediated ubiquitination, and is associated with Li-Fraumeni syndrome. Output strictly as four uppercase characters with no markdown, explanations, prefixes, or trailing punc...	TP53	The prompt is asking for a specific HUGO gene symbol. Let me parse the key identifiers: "Guardian of the genome" — this is the classic epithet for p53, one of the most fundamental tumor suppressors in human biology. Chromosome 17p13.1 — this is the precise cytogenetic location of the TP53 gene. Regulated by MDM2-med...	Hypertension	D070499	Drug_QTETN	modulation	]S4NN13ONCH(352S[HC2
EGFR	Identify the four-letter gene acronym for the specific proto-oncogene product targeted by first-generation tyrosine kinase inhibitors (e.g., erlotinib) in non-small cell lung cancer patients with an exon 19 deletion mutation. This target belongs to the ErbB receptor family but is distinct from HER2, HER3, and HER4. Out...	EGFR	Let me work through this systematically. The question asks for a four-letter gene acronym of a proto-oncogene targeted by first-generation tyrosine kinase inhibitors in NSCLC with exon 19 deletions. First-generation TKIs for NSCLC - erlotinib and gefitinib are the classic examples. These target the epidermal growth f...	Hypertension	D053252	Drug_QCUTQ	modulation	H(#4]S#O=C3([#355#=1
TP53	Identify the official HGNC gene symbol for the primary tumor suppressor protein most frequently mutated in human cancers. Distinguish this gene from its homologs (TP63, TP73) by its specific role in DNA damage response and G1 cell cycle arrest, and its association with Li-Fraumeni syndrome (germline) and sporadic tumor...	TP53	The prompt is asking for the HGNC gene symbol of the most frequently mutated tumor suppressor in human cancers. Let me work through the identifying features provided. The key distinguishing characteristics given are: - Most frequently mutated tumor suppressor in human cancers - Has homologs TP63 and TP73 (this naming ...	Parkinson's Disease	D036812	Drug_XXSPO	modulation	O4H[C#]H6()6HN1241]=
IL6	Identify the cytokine at gene locus 7p21 responsible for B-cell final differentiation and acute-phase protein synthesis. Format the result as a strict 3-character uppercase alphanumeric code (no hyphens, spaces, or markdown). Output ONLY the code.	IL6	I need to identify a cytokine based on specific genetic and functional criteria. Let me work through this systematically: Genetic locus constraint: 7p21 - this is chromosome 7, short arm (p), band 21. Functional constraints: - B-cell final differentiation - the cytokine must drive B cells to mature into anti...	Hypertension	D076591	Drug_VTEOM	modulation	#O[21H[6[2C]5#5S)[)2
IL6	Identify the specific pro-inflammatory cytokine associated with severe cytokine release syndrome that signals via the gp130 receptor subunit, induces hepatic acute-phase protein synthesis (including C-reactive protein), and is encoded by the gene at chromosome locus 7p21. Output only the standard three-character clinic...	IL6	Alright, let me break down this cytokine identification question systematically. Multiple specific criteria are provided, and I need to find the interleukin that satisfies all of them. First clue: pro-inflammatory cytokine associated with severe cytokine release syndrome. In CRS, particularly in the context of CAR-T t...	Hypertension	D015363	Drug_QOGUX	modulation	4([C#]N([PP=1]CP3H5=
TNF	You are an automated entity extraction module for a biomedical knowledge graph. Identify the official three-letter HUGO Gene Nomenclature Committee (HGNC) symbol for the human cytokine encoded by the TNF gene, which mediates acute phase reactions and apoptosis. Output Constraints: - Return ONLY the three-letter upperc...	TNF	The prompt is asking for the official HGNC gene symbol for the cytokine encoded by the TNF gene. Let me work through this carefully. The TNF gene encodes tumor necrosis factor, a cytokine involved in acute phase reactions and apoptosis. The question is asking for the official HGNC-approved gene symbol. Now, I need to...	Breast Cancer	D020810	Drug_TRPCZ	modulation	(PC3]=]=#S53]N[#O5O#
IL6	Retrieve the official HGNC (HUGO Gene Nomenclature Committee) gene symbol for the inflammatory cytokine Interleukin-6. Output strictly the alphanumeric symbol exactly as registered, removing all hyphens, spaces, and prefixes. Provide no explanatory text, citations, markdown, or extra characters. The response must conta...	IL6	The user is asking for the official HGNC gene symbol for Interleukin-6. This is a straightforward nomenclature retrieval question. Interleukin-6 is a well-known inflammatory cytokine. The HGNC (HUGO Gene Nomenclature Committee) has standardized gene symbols that follow specific conventions. For interleukin genes, the ...	Alzheimer's Disease	D034132	Drug_CUYRI	modulation	PHN6642#1HO3=3=5NS]4
PSEN1	Identify the gene encoding the catalytic subunit of the gamma-secretase complex responsible for the majority of autosomal dominant early-onset Alzheimer's disease cases, distinguishing it from PSEN2 and APP based on pathogenic variant prevalence. Output strictly the official HGNC-approved symbol in uppercase. Do not in...	PSEN1	Alright, I need to identify a specific gene here. Let me break down what the question is asking for. The prompt is asking for the gene encoding the catalytic subunit of the gamma-secretase complex. I know the gamma-secretase complex has four main components: presenilin (the catalytic subunit), nicastrin, APH-1, and PE...	Breast Cancer	D096982	Drug_BGBLB	modulation	O(56S=1HN2OH]6SCH[=(
MTOR	Identify the specific serine/threonine protein kinase that acts as the central node in mammalian nutrient sensing, regulates autophagy initiation, and forms two distinct complexes (one sensitive and one insensitive to macrolide immunosuppressants). This kinase phosphorylates downstream effectors including p70-S6 kinase...	MTOR	Let me work through this systematically. The prompt is asking for a serine/threonine kinase with very specific properties. Central node in mammalian nutrient sensing... that immediately brings to mind the master regulator of cellular metabolism. The key clues are: 1. Regulates autophagy initiation - this kinase inhib...	Parkinson's Disease	D062640	Drug_GQEGK	modulation	=S)11H)23C121H=)2](5
TNF	Identify the standard three-letter uppercase acronym for the homotrimeric type II transmembrane protein (a key mediator of acute inflammation produced by macrophages upon LPS stimulation that triggers apoptosis via death receptors). Output ONLY the acronym with no additional text, explanations, or punctuation.	TNF	Let me work through this systematically. The prompt asks for a three-letter uppercase acronym for a specific protein. Let me identify the key characteristics: 1. Homotrimeric type II transmembrane protein 2. Key mediator of acute inflammation 3. Produced by macrophages upon LPS stimulation 4. Triggers apoptosis via d...	Parkinson's Disease	D044697	Drug_GKVJO	modulation	PH1(416OHPN=S31#PPH1
BRCA1	Identify the HGNC-approved gene symbol for the tumor suppressor in Hereditary Breast and Ovarian Cancer (HBOC) syndrome that meets these criteria: - Located on chromosome 17q21.31 - Encodes a RING finger domain-containing protein essential for homologous recombination repair - Forms a heterodimer with BARD1 - Explicitl...	BRCA1	Let me work through this systematically. The question asks for an HGNC-approved gene symbol for a tumor suppressor in HBOC syndrome with specific criteria. First, I need to recall the major genes associated with HBOC syndrome. The two primary tumor suppressor genes are BRCA1 and BRCA2. Now let me verify each criterio...	Hypertension	D038333	Drug_QGBDB	modulation	H[=463)2N#C#O64PS[SP
TNF	Identify the canonical three-letter uppercase acronym for the homotrimeric signaling protein historically known as cachectin, which mediates systemic inflammation and the acute phase reaction. Strictly output only the three-letter acronym in uppercase. Exclude all isoform specifiers (e.g., alpha, beta), punctuation, wh...	TNF	The question asks for the canonical three-letter acronym for the homotrimeric signaling protein historically known as cachectin. Cachectin was the original name for this cytokine before it was identified as identical to tumor necrosis factor. This protein is indeed a homotrimer that plays a central role in mediating sy...	Breast Cancer	D079189	Drug_JYHZS	modulation	#]S])2HP[6OC2(562(P=
VEGFA	Identify the specific vascular endothelial growth factor (VEGF) family member that is primarily induced by hypoxia via HIF-1α binding to its promoter and is located on chromosome 6p21.1 (distinguishing it from VEGFB on 11q13 and VEGFC on 4q34). Output strictly the approved HGNC gene symbol in uppercase letters. Do not ...	VEGFA	I need to identify a VEGF family member based on several key criteria. Let me work through this systematically. The prompt specifies: 1. Primary induction by hypoxia via HIF-1α binding to the promoter 2. Chromosomal location at 6p21.1 3. Distinguished from VEGFB (11q13) and VEGFC (4q34) From my knowledge of the VEGF ...	Alzheimer's Disease	D089401	Drug_IPQOM	modulation	(22P4]H=(4NN3P)O145)
PSEN1	Identify the official HGNC gene symbol for the gene located at chromosome 14q24.3 that encodes the catalytic core of the gamma-secretase complex and causes most early-onset familial Alzheimer's disease (EOFAD) cases linked to presenilin mutations. Output Constraints: Return strictly the single gene symbol token. Do not...	PSEN1	Let me work through this systematically. The prompt is asking for a specific HGNC gene symbol with several identifying criteria. First, I need to identify what gene is located at chromosome 14q24.3. The cytogenetic band 14q24.3 is on the long arm of chromosome 14. Second, the gene must encode the catalytic core of th...	Diabetes	D081453	Drug_YHCNI	modulation	]C6423]SPSO25(1O5414
EGFR	Identify the official HGNC gene symbol for the ErbB family transmembrane receptor tyrosine kinase associated with exon 19 deletions and L858R mutations in non-small cell lung cancer, which predicts response to gefitinib and erlotinib via MAPK and PI3K-Akt signaling. Output strictly the four-letter uppercase acronym wit...	EGFR	I need to identify a gene from the ErbB family based on specific molecular characteristics in non-small cell lung cancer. The ErbB family consists of four receptor tyrosine kinases: ErbB1, ErbB2, ErbB3, and ErbB4. The prompt mentions exon 19 deletions and L858R mutations as biomarkers predicting response to gefitinib ...	Parkinson's Disease	D090083	Drug_FDZYE	modulation	521O=CCNS53OHP#[)=(=
TP53	Identify the official HGNC (HUGO Gene Nomenclature Committee) gene symbol for the tumor suppressor protein p53, located at chromosome 17p13.1 with the highest mutation frequency in human cancers. Output strictly the uppercase alphanumeric gene identifier only. Exclude all protein names, descriptions, markdown, punctuat...	TP53	The prompt is asking for the official HGNC gene symbol for p53, the well-known tumor suppressor. Let me recall the key facts about this gene. p53 is perhaps the most famous tumor suppressor in cancer biology. It's located at chromosome 17p13.1 and has the highest mutation frequency across human cancers - mutations in ...	Parkinson's Disease	D075072	Drug_BSBSV	modulation	P#SPH4O25##6#(6SO)CS
AKT1	Identify the specific gene symbol for the alpha isoform of Protein Kinase B (AKT1) within the PI3K/AKT/mTOR pathway. This isoform is characterized by the oncogenic E17K hotspot mutation in its pleckstrin homology domain and is commonly associated with breast and colorectal carcinomas. Explicitly exclude AKT2 and AKT3 v...	AKT1	The question asks for the gene symbol of the alpha isoform of Protein Kinase B, with specific mention of the E17K mutation in the pleckstrin homology domain. This is straightforward—the three AKT isoforms are well-characterized in the PI3K/AKT/mTOR pathway. AKT1 is the alpha isoform, AKT2 is beta, and AKT3 is gamma. Th...	Alzheimer's Disease	D098896	Drug_YWFZP	modulation	3C523#C4H=H=)][1=H2#
AKT1	Identify the HGNC-approved gene symbol for the serine/threonine kinase isoform alpha (AKT1) that mediates signaling hyperactivation downstream of PIP3 and upstream of mTORC1. Ensure strict differentiation from homologous isoforms AKT2 and AKT3. Output Constraints: Return ONLY the uppercase gene symbol. Exclude all whit...	AKT1	The prompt is asking for the HGNC-approved gene symbol for the serine/threonine kinase isoform alpha. Let me work through this systematically. The AKT family consists of three homologous isoforms: - AKT1 (PKBα) - the alpha isoform - AKT2 (PKBβ) - the beta isoform - AKT3 (PKBγ) - the gamma isoform The prompt specifi...	Breast Cancer	D045986	Drug_ZLORV	modulation	=#63[=]#NN3#O11(6)O5
TNF	Identify the official HGNC (HUGO Gene Nomenclature Committee) symbol for the pro-inflammatory cytokine encoded at chromosomal locus 6p21.3 that is targeted by the monoclonal antibody adalimumab. Output strictly the three-letter uppercase gene acronym with no surrounding text, punctuation, or whitespace.	TNF	Alright, let me work through this systematically. The question asks for a gene symbol with three specific identifiers I need to reconcile. First, adalimumab — that's Humira. I know this drug well. It's a fully human monoclonal antibody (IgG1) that neutralizes TNF-alpha. It's been a cornerstone biologic for rheumatoid ...	Hypertension	D004442	Drug_ABQFN	modulation	C1=N64SN3S3[5]S3N654
IL6	Identify the specific pro-inflammatory interleukin that meets all three of the following criteria: 1. It is the primary mediator responsible for hepatic acute-phase protein synthesis. 2. It utilizes the gp130 receptor subunit for signal transduction. 3. It is the specific molecular target for the monoclonal antibody to...	IL6	I need to identify a pro-inflammatory interleukin that satisfies all three criteria simultaneously. Let me work through each criterion systematically. Criterion 1: Primary mediator of hepatic acute-phase protein synthesis When hepatocytes synthesize acute-phase proteins (CRP, fibrinogen, serum amyloid A) during ...	Alzheimer's Disease	D011668	Drug_HXVDN	modulation	HN3PH5(]SC6#)3#(2]]1
VEGFA	Identify the official HGNC gene symbol for the primary VEGF family ligand that binds VEGFR-2 to drive pathological angiogenesis in non-small cell lung cancer, explicitly excluding VEGFB, VEGFC, and PLGF (Placental Growth Factor). Output strictly the 5-letter gene symbol in all uppercase characters. Do not include any p...	VEGFA	I need to identify the primary VEGF family ligand that binds VEGFR-2 to drive pathological angiogenesis in NSCLC, while excluding VEGFB, VEGFC, and PLGF. Let me recall the VEGF family members: VEGFA, VEGFB, VEGFC, VEGFD, and PLGF. The prompt excludes VEGFB, VEGFC, and PLGF, leaving VEGFA and VEGFD as candidates. VEGF...	Hypertension	D021081	Drug_SYBRS	modulation	N6#]]6CN))#2[2C6(=P5
TP53	Identify the official HGNC symbol for the gene encoding the p53 protein, which is the critical tumor suppressor altered in Li-Fraumeni syndrome and sporadic cancers. Output ONLY the four-character uppercase alphanumeric symbol. Strictly exclude all markdown, punctuation, prefixes, explanations, or extra text.	TP53	The prompt asks for the official HGNC gene symbol encoding p53. This is straightforward molecular genetics - p53 is the protein product, and I need the corresponding gene symbol approved by the HUGO Gene Nomenclature Committee. The gene encoding p53 is one of the most intensively studied in cancer biology. Li-Fraumeni...	Diabetes	D049614	Drug_FTOHK	modulation	6)(](C(4]#3[NP#S==5H
IL6	Identify the specific cytokine that meets all the following immunological criteria: 1. Signaling Pathway: Must signal via the JAK/STAT3 pathway. 2. Cellular Function: Must be essential for the differentiation of Th17 cells. 3. Pharmacological Inhibition: Must be inhibited by tocilizumab (an IL-6 receptor a...	IL6	Let me work through each criterion systematically. First, I need to consider cytokines that signal through JAK/STAT3. This immediately brings to mind the IL-6 family of cytokines, which all utilize the gp130 receptor subunit and activate STAT3 phosphorylation via JAK kinases. Now examining Th17 differentiation requir...	Breast Cancer	D049531	Drug_VTPOP	modulation	OC2[254P=44)O#53PCNS
TNF	Identify the canonical three-letter clinical pharmacology acronym for the homotrimeric transmembrane cytokine that is cleaved by TACE to release a soluble form, binds TNFRSF1A and TNFRSF1B, and triggers NF-kB signaling pathways implicated in rheumatoid arthritis and Crohn's disease. Constraints: - Output strictly the ...	TNF	Let me work through this systematically. The question describes a cytokine with several specific characteristics that I need to match. First, it's described as a homotrimeric transmembrane cytokine. This immediately narrows the field significantly—most cytokines are monomeric or dimeric. The homotrimeric structure is ...	Breast Cancer	D096680	Drug_HSNNV	modulation	HP4H31#C5OPHOP(6([4]
AKT1	Identify the official HGNC gene symbol for the serine/threonine-protein kinase that acts as a central node in the PI3K-AKT-mTOR pathway, is encoded at chromosomal location 14q32.33, corresponds to UniProt entry P31749, and represents the alpha isoform frequently mutated in breast and endometrial cancers. Output strictl...	AKT1	Alright, let me work through this systematically. I need to identify a specific gene symbol from multiple lines of evidence. The prompt describes a serine/threonine-protein kinase that's a central node in the PI3K-AKT-mTOR pathway. That immediately narrows things down considerably. The core signaling nodes in this pat...	Alzheimer's Disease	D025255	Drug_FLMWQ	modulation	62S=3])5456S1(]1)=)4
MTOR	Identify the specific serine/threonine kinase that acts as the central regulator of cell growth, proliferation, and survival in eukaryotic signaling. This protein is the mammalian ortholog of the yeast TOR1 gene, serves as the catalytic core for both mTORC1 and mTORC2 complexes, and binds the rapamycin-FKBP12 complex. ...	MTOR	Alright, let me work through this systematically. The prompt is asking for a serine/threonine kinase with very specific properties. Let me parse the key identifiers: 1. Central regulator of cell growth, proliferation, and survival in eukaryotic signaling 2. Mammalian ortholog of yeast TOR1 gene 3. Catalytic core for ...	Parkinson's Disease	D059202	Drug_LNPWR	modulation	=6N3)=226]N)[]2HS[5O

This dataset is a remastered version prepared using Adaption's Adaptive Data platform.

gene_symbols

This dataset consists of a collection of human gene symbols, including well-known entries like VEGFA, TNF, and BRCA1. Each sample represents a single gene identifier formatted as a standard uppercase text string. The data appears to be a curated list of significant genes often associated with cancer research or cellular signaling pathways.