Datasets:

linjc16
/

TrialAlign

text stringlengths 0 214k	source stringclasses 15 values
Hormone Therapy and Ipilimumab in Treating Patients With Advanced Prostate Cancer Study Overview ================= Brief Summary ----------------- RATIONALE: Androgens can cause the growth of prostate cancer cells. Antihormone therapy, such as leuprolide acetate, goserelin, flutamide, or bicalutamide may lessen the am...	ctgov
Cancer, Physical Activity and Quality of Life- a Longterm Follow up Study Overview ================= Brief Summary ----------------- This project is a 6-8-years follow-up of a randomized controlled trial testing a stepped care stress management program. The main goal is to examining differences in long-term effects on...	ctgov
Weight-Adjusted Dosing of 3-OHB in Patients With Chronic Heart Failure Study Overview ================= Brief Summary ----------------- We aim to investigate the hemodynamic effects of weight-adjusted dosing of ketone monoester en patients with chronic heart failure. Official Title ----------------- Weight-Adjusted D...	ctgov
Safety and Efficacy of Using HDH Device and Method - a Novel Sutureless Vascular Anastomosis Study Overview ================= Brief Summary ----------------- The HDH device is intended for creating sutureless vascular anastomosis in various blood vessels. The HDH device consists of four parts: an elastic tube (graft),...	ctgov
Reducing Adverse Drug Events in the Nursing Home Study Overview ================= Brief Summary ----------------- Medications are the single most common form of treatment in the long-term care setting, and often represent the most efficacious (and cost-effective) therapeutic modality used in this clinical setting. How...	ctgov
Tea and Forearm Blood Flow Study Overview ================= Brief Summary ----------------- The study will explore the benefit of tea for microcirculation. Subjects will consume tea ar a placebo matched for taste and appearance in a blinded cross over design. Detailed Description ----------------- Epidemiological stu...	ctgov
Clinical Features of Smoker Patients With Chronic Obstructive Pulmonary Disease Study Overview ================= Brief Summary ----------------- Smoking is the most important factor in the etiology of COPD. Some of the patients with COPD continue to smoke despite knowing this situation or they cannot quit even if they...	ctgov
A Phase 3 Clinical Trial to Evaluate the Safety and Efficacy of Ensifentrine in Patients With COPD Study Overview ================= Brief Summary ----------------- The purpose of this study is to evaluate the efficacy and safety of ensifentrine in patients with moderate to severe Chronic Obstructive Pulmonary Disease ...	ctgov
A Clinical Trial of Oral Suberoylanilide Hydroxamic Acid (SAHA) in Patients With Relapsed or Refractory Breast, Colorectal and Non-Small Cell Lung Cancer (0683-011)(TERMINATED) Study Overview ================= Brief Summary ----------------- This is an investigational study to determine the response rate of relapsed/r...	ctgov
Acute Exposure of Simulated Hypoxia on Pulmonary Artery Pressure and Right Heart Function (Echo) Study Overview ================= Brief Summary ----------------- Randomized crossover trial in patients with Pulmonary Hypertension (PAH, CTEPH) to assess the acute response to simulated altitude (FiO2:15.1, equivalent to ...	ctgov
EDWARDS INTUITY Valve System CADENCE Study Study Overview ================= Brief Summary ----------------- The study purpose is to compare the EDWARDS INTUITY valve system with commercially available stented aortic bioprostheses, in patients requiring aortic valve replacement surgery with coronary artery bypass. Det...	ctgov
Study to Investigate an Immunomodulatory Therapy in Adult Patients With Perennial Allergic Rhinoconjunctivitis Study Overview ================= Brief Summary ----------------- The purpose of the study is to test the efficacy of a vaccine against house dust mite and/or cat allergy compared to placebo in adult patients....	ctgov
A Phase IV Study to Assess the Safety of EupentaTM Inj Study Overview ================= Brief Summary ----------------- A prospective, open-label, interventional phase IV study to assess the safety of EupentaTM Inj.{fully liquid pentavalent vaccine, Adsorbed Diphtheria-Tetanus-whole-cell Pertussis-Hepatitis B (rDNA [r...	ctgov
Eastern Caribbean Health Outcomes Research Network (ECHORN) Study Overview ================= Brief Summary ----------------- The Eastern Caribbean Health Outcomes Research Network (ECHORN) is a collaborative research study that examines the lifestyles, eating habits, and health behaviors associated with cancer, diabet...	ctgov
Investigating the Gut Microbiota Modulation Effects of Allicin for Cardiovascular Disease Protection and Establishing Microbiota Directed Personalized Nutrition Guidance With Novel Humanized Gnotobiotic Mice Model, Microbial Culturomics and Metabolomic Technique Study Overview ================= Brief Summary ---------...	ctgov
Platelet-Rich Plasma in the Treatment of Patients With Idiopathic Carpal Tunnel Syndrome Study Overview ================= Brief Summary ----------------- This is a randomized controlled trial in a cohort of Egyptian patients suffered from mild to moderate idiopathic carpal tunnel. They were randomly divided into two g...	ctgov
Efficacy and Safety of Sofosbuvir/Velpatasvir ± Ribavirin for 12 Weeks in Adults With Chronic HCV Infection and Decompensated Cirrhosis Study Overview ================= Brief Summary ----------------- The primary objectives of this study are to evaluate the antiviral efficacy, safety, and tolerability of sofosbuvir/ve...	ctgov
Strategies to Continue Gynae-oncology Services in the Era of COVID-19 Outbreak: Concerns and Challenges in a Referral Centre in Malaysia Study Overview ================= Brief Summary ----------------- A short survey involving 100 participants was conducted online to explore the understanding of Covid 19 pandemic impa...	ctgov
Study of ME-401 in Subjects With Relapsed or Refractory Indolent B-cell Non-Hodgkin's Lymphoma Study Overview ================= Brief Summary ----------------- The purpose of this study is to evaluate the safety, tolerability, and pharmacokinetics of ME-401 in the treatment of Japanese participants with Relapsed or Re...	ctgov
Evaluation of the Interaction Between Low Dose Sulfamethoxazole-Trimethoprim and Zidovudine Study Overview ================= Brief Summary ----------------- To determine if the pharmacokinetics of low doses of zidovudine (AZT) (that is, how fast AZT reaches the blood, what concentration of AZT is attained in the blood...	ctgov
Muscle Relaxation for Short Procedures Study Overview ================= Brief Summary ----------------- Succinylcholine is commonly used for neuromuscular relaxation for short procedures such as rigid bronchoscopy. A more modern alternative is the application of low-dose rocuronium, reversed by low-dose sugammadex. Th...	ctgov
Balneotherapy and Anxiety During SARS-CoV-2 Pandemic Study Overview ================= Brief Summary ----------------- Investigators will measure the level of anxiety and fear of Covid during the balneological treatment in patients. They are interested in the effect of general trust and resilience on the level of anxie...	ctgov
Accessory Pathway Antegrade Effective Refractory Period Among WPW Patients: the Risk in Relation to the Location Study Overview ================= Brief Summary ----------------- To correlate the antegrade effective refractory period of the accessory pathway with its anatomical location in the heart. To investigate whe...	ctgov
Assessing the Analgesic Efficacy of Naproxen Sodium in Postsurgical Dental Pain. Study Overview ================= Brief Summary ----------------- To evaluate the analgesic efficacy of a single, oral dose of a naproxen sodium extended-release tablet, compared to placebo in postsurgical dental pain. Official Title ----...	ctgov
The Effect of Telerehabilitation on Symptoms in Fibromyalgia Patients Study Overview ================= Brief Summary ----------------- The aim of this study is to evaluate the effect of telerehabilitation-based high-intensity interval upper extremity exercise training on biochemistry parameters and disease symptoms in...	ctgov
The Risk of Exacerbation of Chronic Hepatitis B After Percutaneous Radiofrequency Ablation of Hepatocellular Carcinoma Study Overview ================= Brief Summary ----------------- This study aim to find out the risk of exacerbation of chronic hepatitis B after percutaneous radiofrequency ablation (RFA) or hepatect...	ctgov
A Study in Healthy Men to Test How BI 456906 is Processed in the Body Study Overview ================= Brief Summary ----------------- This trial is intended to examine the basic pharmacokinetics of BI 456906 and total [14C]-radioactivity, including mass balance, excretion pathways and metabolism following a single su...	ctgov
Determining Optimal Dose and Duration of Diuretic Treatment in People With Acute Heart Failure (The DOSE-AHF Study) Study Overview ================= Brief Summary ----------------- Heart failure is a disorder in which the heart does not pump blood adequately. This can lead to several serious problems, including reduce...	ctgov
Surgical Therapy and Survival in HCC/ C.F. Zhang et al. Study Overview ================= Brief Summary ----------------- This study utilizes a new method to explore compare the overall survival (OS) and cancer-specific survival (CSS) in patients aged 18-45 years with stage I-II HCC who underwent different types of sur...	ctgov
Montelukast in Perennial Allergic Rhinitis - 2001-2002 Study (0476-246) Study Overview ================= Brief Summary ----------------- This study will assess the ability of montelukast to improve the signs and symptoms of perennial allergic rhinitis compared to placebo. Cetirizine is included in the study as an acti...	ctgov
Behavioral Pharmacology Associated With Cigar Smoking Study Overview ================= Brief Summary ----------------- Lovelace Scientific Resources is conducting clinical research study for cigar smokers. This study will be evaluating the behaviors of cigar smokers and the short term effects of cigar smoking. A cigar...	ctgov
[Trial of device that is not approved or cleared by the U.S. FDA] Study Overview ================= Official Title ----------------- [Trial of device that is not approved or cleared by the U.S. FDA] Participation Criteria ================= Ages Eligible for Study ----------------- Minimum Age: Maximum Age: Study...	ctgov

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TrialAlign

🤗 [Panacea Model] • 💻 [Github Repo] • 📃 [Panacea Paper]

TrialAlign datasets are the continual pretraining corpus for "Panacea: A foundation model for clinical trial search, summarization, design, and recruitment". TrialAlign contains 793,279 clinical trial design documents worldwide and 1,113,207 clinical study papers.

Load the dataset

pip install -U datasets fsspec

from datasets import load_dataset
ds = load_dataset('linjc16/ctgov', split='train')

Statistics of TrialAlign

Source	Counts
ClinicalTrials.gov	432,676
ChiCTR (China)	65,181
EUCTR (EU)	43,315
JRCT (Japan)	60,645
ANZCTR (Australia/New Zealand)	23,374
ISRCTN.org	22,966
ReBEC (Brazil)	5,889
CRIS (Korea)	8,428
DRKS (Germany)	13,789
IRCT (Iran)	34,097
TCTR (Thailand)	7,443
LTR (Netherlands)	9,768
PACTR (Africa)	3,848
SLCTR (Sri Lanka)	421
Trial Papers (Embase + PubMed)	1,113,207

Citation

If you find our work useful, please consider citing Panacea:

@article{lin2024panacea,
  title={Panacea: A foundation model for clinical trial search, summarization, design, and recruitment},
  author={Lin, Jiacheng and Xu, Hanwen and Wang, Zifeng and Wang, Sheng and Sun, Jimeng},
  journal={arXiv preprint arXiv:2407.11007},
  year={2024}
}

Downloads last month: 27

Number of rows:

939,130

Estimated number of rows:

1,718,124

Total file size:

9.15 GB

Paper for linjc16/TrialAlign

Panacea: A foundation model for clinical trial search, summarization, design, and recruitment

Paper • 2407.11007 • Published Jun 25, 2024