Datasets:
prompt dict | question stringlengths 40 2.45k | answer stringclasses 9
values | type stringclasses 4
values | domain stringclasses 4
values | details dict | answerKey stringclasses 5
values | choices dict | sample_id stringlengths 24 24 | dataset_index int64 4.02k 28.1k | selection_seed int64 20.3M 20.3M | selection_name stringclasses 1
value | selection_group stringclasses 12
values | selection_domain stringclasses 4
values | selection_level stringclasses 3
values | selection_type stringclasses 4
values | target stringclasses 12
values |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
{
"default": "Please read the text carefully and choose the correct answer from the multiple-choice options based on your understanding of the details or data described. Your answer should be \"A\", \"B\", \"C\" or \"D\". Please directly give the answer without any explanation."
} | Photosynthesis is a process where light energy is trapped and stored as chemical energy, while the reverse process occurs when we consume food. The substances in food are converted into carbon dioxide, water, and energy. This energy is partly used to maintain our body temperature at an average level and to drive chemic... | mcq-4-choices | Biology | {
"level": "L2",
"source": "one.libretexts",
"subtask": "detailed_understanding",
"task": "L2_General"
} | D | {
"label": [
"A",
"B",
"C",
"D"
],
"text": [
"To increase body temperature to above normal levels",
"To reduce the body temperature during physical activities",
"To produce carbon dioxide and water",
"To help maintain body temperature within a normal range"
]
} | sciknow_6084e659010bbc93 | 5,070 | 20,260,428 | sciknoweval_v2_hard_autogradable_512_2026_04_28 | Biology_L2 | Biology | L2 | mcq-4-choices | D | |
{
"default": "Please read the text carefully and choose the correct answer from the multiple-choice options based on your understanding of the details or data described. Your answer should be \"A\", \"B\", \"C\" or \"D\". Please directly give the answer without any explanation."
} | Eukaryotic cells have developed an intricate endomembrane system that includes membrane-bound organelles which are essential for various cellular functions. These organelles encompass the endoplasmic reticulum (ER), Golgi apparatus, and vesicles. The ER is divided into two types: the smooth ER, which is involved in lip... | mcq-4-choices | Biology | {
"level": "L2",
"source": "one.libretexts",
"subtask": "detailed_understanding",
"task": "L2_General"
} | A | {
"label": [
"A",
"B",
"C",
"D"
],
"text": [
"Synthesis of proteins destined for the cell membrane",
"Degrading various substances ingested by the cell",
"Processing proteins and lipids by adding sugar molecules",
"Detoxification of toxic compounds"
]
} | sciknow_37c7c6fd0423fbe3 | 5,109 | 20,260,428 | sciknoweval_v2_hard_autogradable_512_2026_04_28 | Biology_L2 | Biology | L2 | mcq-4-choices | A | |
{
"default": "Please read the text carefully and choose the correct answer from the multiple-choice options based on your understanding of the details or data described. Your answer should be \"A\", \"B\", \"C\" or \"D\". Please directly give the answer without any explanation."
} | The human low molecular weight protein tyrosine phosphatase (1xww) has an active site where sulfate is bound, mimicking the phosphate on the p-Tyr protein target. This sulfate is deeply buried within the active site, which features a pocket surrounded by the side chains of Tyrosine 131 and 132, and Tryptophan 49. These... | mcq-4-choices | Biology | {
"level": "L2",
"source": "one.libretexts",
"subtask": "detailed_understanding",
"task": "L2_General"
} | B | {
"label": [
"A",
"B",
"C",
"D"
],
"text": [
"Aspartate 129",
"Lysine 50",
"Tyrosine 131",
"Tryptophan 49"
]
} | sciknow_8bd115e091e5fd5e | 5,192 | 20,260,428 | sciknoweval_v2_hard_autogradable_512_2026_04_28 | Biology_L2 | Biology | L2 | mcq-4-choices | B | |
{
"default": "Please read the text carefully and choose the correct answer from the multiple-choice options based on your understanding of the details or data described. Your answer should be \"A\", \"B\", \"C\" or \"D\". Please directly give the answer without any explanation."
} | Fungal cellulases, crucial for the degradation of cellulose, are categorized into glycoside hydrolase (GH) families 5, 6, 7, 12, and 45. These enzymes include various types such as endoglucanases, exoglucanases, and β-glucosidases (BG). A particular focus is on cellobiohydrolases (CBHs), which are well-studied enzymes ... | mcq-4-choices | Biology | {
"level": "L2",
"source": "one.libretexts",
"subtask": "detailed_understanding",
"task": "L2_General"
} | C | {
"label": [
"A",
"B",
"C",
"D"
],
"text": [
"GH family 5",
"GH family 45",
"GH family 10",
"GH family 12"
]
} | sciknow_1157caa2a0be3372 | 5,216 | 20,260,428 | sciknoweval_v2_hard_autogradable_512_2026_04_28 | Biology_L2 | Biology | L2 | mcq-4-choices | C | |
{
"default": "Please read the text carefully and choose the correct answer from the multiple-choice options based on your understanding of the details or data described. Your answer should be \"A\", \"B\", \"C\" or \"D\". Please directly give the answer without any explanation."
} | The text contains information regarding the modeling of oxygen binding to hemoglobin (Hb) using different mathematical models. Specifically, when L is set to 9000 and c equals 0.014, the Y vs. α curve effectively matches experimental data on oxygen binding. The text compares experimental data with theoretical models: t... | mcq-4-choices | Biology | {
"level": "L2",
"source": "one.libretexts",
"subtask": "detailed_understanding",
"task": "L2_General"
} | A | {
"label": [
"A",
"B",
"C",
"D"
],
"text": [
"L",
"Kr",
"n",
"c"
]
} | sciknow_3cd4bd0012dbc2a1 | 5,227 | 20,260,428 | sciknoweval_v2_hard_autogradable_512_2026_04_28 | Biology_L2 | Biology | L2 | mcq-4-choices | A | |
{
"default": "Please read the text carefully and choose the correct answer from the multiple-choice options based on your understanding of the details or data described. Your answer should be \"A\", \"B\", \"C\" or \"D\". Please directly give the answer without any explanation."
} | Highly transcriptionally active genes often have multiple RNA polymerases (RNAP) simultaneously transcribing them, with each RNAP following closely behind another. This is possible because an RNAP only needs to transcribe about 15 nucleotides before there is enough space on the DNA for another RNAP to bind to the promo... | mcq-4-choices | Biology | {
"level": "L2",
"source": "one.libretexts",
"subtask": "detailed_understanding",
"task": "L2_General"
} | B | {
"label": [
"A",
"B",
"C",
"D"
],
"text": [
"10 nucleotides",
"15 nucleotides",
"5 nucleotides",
"20 nucleotides"
]
} | sciknow_9f9f8cac4faf0307 | 5,261 | 20,260,428 | sciknoweval_v2_hard_autogradable_512_2026_04_28 | Biology_L2 | Biology | L2 | mcq-4-choices | B | |
{
"default": "Please read the text carefully and choose the correct answer from the multiple-choice options based on your understanding of the details or data described. Your answer should be \"A\", \"B\", \"C\" or \"D\". Please directly give the answer without any explanation."
} | The trp operon contains five genes essential for the synthesis of the amino acid tryptophan. These genes are trpE and trpD, which together code for the subunits of anthranilate synthetase; trpC, which codes for N-(5’-phosphoribosyl)-anthranilate isomerase; and trpB and trpA, each coding for subunits of tryptophan synth... | mcq-4-choices | Biology | {
"level": "L2",
"source": "one.libretexts",
"subtask": "detailed_understanding",
"task": "L2_General"
} | C | {
"label": [
"A",
"B",
"C",
"D"
],
"text": [
"trpA",
"trpB",
"trpE",
"trpC"
]
} | sciknow_41fb2f118fc57747 | 5,311 | 20,260,428 | sciknoweval_v2_hard_autogradable_512_2026_04_28 | Biology_L2 | Biology | L2 | mcq-4-choices | C | |
{
"default": "Please read the text carefully and choose the correct answer from the multiple-choice options based on your understanding of the details or data described. Your answer should be \"A\", \"B\", \"C\" or \"D\". Please directly give the answer without any explanation."
} | The innate immune response is triggered within 96 hours of exposure to an infectious agent through the interaction of pathogen-associated molecular patterns (PAMPs) and danger-associated molecular patterns (DAMPs) with pattern-recognition receptors (PRRs) on body cells. PAMPs are essential molecules shared by groups of... | mcq-4-choices | Biology | {
"level": "L2",
"source": "one.libretexts",
"subtask": "detailed_understanding",
"task": "L2_General"
} | C | {
"label": [
"A",
"B",
"C",
"D"
],
"text": [
"They suppress the immune system.",
"They directly destroy pathogens.",
"They facilitate the recruitment of defense cells.",
"They produce antibodies."
]
} | sciknow_2cbda7fb2db77f5a | 5,314 | 20,260,428 | sciknoweval_v2_hard_autogradable_512_2026_04_28 | Biology_L2 | Biology | L2 | mcq-4-choices | C | |
{
"default": "Please read the text carefully and choose the correct answer from the multiple-choice options based on your understanding of the details or data described. Your answer should be \"A\", \"B\", \"C\" or \"D\". Please directly give the answer without any explanation."
} | In DNA extraction, nonpolar substances like lipids and cellular debris partition into the nonpolar chloroform/phenol phase or remain suspended at the interface. Chloroform, containing a dense chlorine atom, and phenol, slightly soluble in water but highly soluble in chloroform, are used in the process. The interaction ... | mcq-4-choices | Biology | {
"level": "L2",
"source": "one.libretexts",
"subtask": "detailed_understanding",
"task": "L2_General"
} | A | {
"label": [
"A",
"B",
"C",
"D"
],
"text": [
"The potential damage to DNA by phenol",
"The cost of chloroform and phenol",
"The solubility issues of DNA in chloroform and phenol",
"The difficulty in handling chloroform and phenol"
]
} | sciknow_36660e1adf058e79 | 5,324 | 20,260,428 | sciknoweval_v2_hard_autogradable_512_2026_04_28 | Biology_L2 | Biology | L2 | mcq-4-choices | A | |
{
"default": "Please read the text carefully and choose the correct answer from the multiple-choice options based on your understanding of the details or data described. Your answer should be \"A\", \"B\", \"C\" or \"D\". Please directly give the answer without any explanation."
} | Lateral flow tests, similar to ELISA techniques, utilize antibody sandwiches which provide sensitivity and specificity. These tests are advantageous because they are fast, inexpensive, and do not require special equipment, making them accessible for use by anyone anywhere. The procedure involves antibody-antigen comple... | mcq-4-choices | Biology | {
"level": "L2",
"source": "one.libretexts",
"subtask": "detailed_understanding",
"task": "L2_General"
} | D | {
"label": [
"A",
"B",
"C",
"D"
],
"text": [
"Red or blue color at the control line",
"Color development only at the control line",
"No color change at any line",
"Red or blue color at the test line"
]
} | sciknow_76a98b2ed5abce0f | 5,337 | 20,260,428 | sciknoweval_v2_hard_autogradable_512_2026_04_28 | Biology_L2 | Biology | L2 | mcq-4-choices | D | |
{
"default": "Please read the text carefully and choose the correct answer from the multiple-choice options based on your understanding of the details or data described. Your answer should be \"A\", \"B\", \"C\" or \"D\". Please directly give the answer without any explanation."
} | Histidine is a strong base at physiological pH levels and can exist in two tautomeric forms. NMR studies indicate that in model peptides, the proton predominantly resides on the ε-N or tele-N in the imidazole ring of histidine, which has a pKa that is 0.6 units higher than the δ-N or pro-N. This suggests that the struc... | mcq-4-choices | Biology | {
"level": "L2",
"source": "one.libretexts",
"subtask": "detailed_understanding",
"task": "L2_General"
} | A | {
"label": [
"A",
"B",
"C",
"D"
],
"text": [
"On the ε-N or tele-N",
"On the δ-N or pro-N",
"Outside of the imidazole ring",
"On both the δ-N and ε-N equally"
]
} | sciknow_6d27d72ce750b92e | 5,356 | 20,260,428 | sciknoweval_v2_hard_autogradable_512_2026_04_28 | Biology_L2 | Biology | L2 | mcq-4-choices | A | |
{
"default": "Please read the text carefully and choose the correct answer from the multiple-choice options based on your understanding of the details or data described. Your answer should be \"A\", \"B\", \"C\" or \"D\". Please directly give the answer without any explanation."
} | Magnetoencephalography (MEG) offers direct spatial and temporal measurements of brain activity, which is especially advantageous when compared to functional MRI (fMRI). While fMRI measures brain activity indirectly by assessing oxygen levels from blood flow in active brain regions during cognitive tasks involving traum... | mcq-4-choices | Biology | {
"level": "L2",
"source": "one.libretexts",
"subtask": "detailed_understanding",
"task": "L2_General"
} | C | {
"label": [
"A",
"B",
"C",
"D"
],
"text": [
"MEG requires cognitive tasks to measure brain activity.",
"MEG requires less expensive equipment than fMRI.",
"MEG provides direct measurements of brain activity.",
"MEG uses more accessible technology than fMRI."
]
} | sciknow_6ac3108417ff2185 | 5,417 | 20,260,428 | sciknoweval_v2_hard_autogradable_512_2026_04_28 | Biology_L2 | Biology | L2 | mcq-4-choices | C | |
{
"default": "Please read the text carefully and choose the correct answer from the multiple-choice options based on your understanding of the details or data described. Your answer should be \"A\", \"B\", \"C\" or \"D\". Please directly give the answer without any explanation."
} | The text describes two types of microscopes used for observing living, unstained cells: the dark-field microscope and the phase-contrast microscope. The dark-field microscope illuminates the sample with a hollow cone of light against a dark background, enabling the observation of features like motility or eukaryotic or... | mcq-4-choices | Biology | {
"level": "L2",
"source": "one.libretexts",
"subtask": "detailed_understanding",
"task": "L2_General"
} | A | {
"label": [
"A",
"B",
"C",
"D"
],
"text": [
"The dark-field microscope creates a bright image against a dark background, whereas the phase-contrast microscope produces a dark image against a bright background.",
"The dark-field microscope uses a solid cone of light, while the phase-contra... | sciknow_8d7acfebcc857caa | 5,423 | 20,260,428 | sciknoweval_v2_hard_autogradable_512_2026_04_28 | Biology_L2 | Biology | L2 | mcq-4-choices | A | |
{
"default": "Please read the text carefully and choose the correct answer from the multiple-choice options based on your understanding of the details or data described. Your answer should be \"A\", \"B\", \"C\" or \"D\". Please directly give the answer without any explanation."
} | In the hypothalamus, AMPK serves as a crucial monitor of cellular energy status, often described as a 'fuel gauge.' Its activity can be influenced by various factors: leptin and insulin inhibit AMPK, promoting an anorexigenic effect which suppresses appetite. Conversely, fructose has been found to activate AMPK, leadin... | mcq-4-choices | Biology | {
"level": "L2",
"source": "one.libretexts",
"subtask": "detailed_understanding",
"task": "L2_General"
} | C | {
"label": [
"A",
"B",
"C",
"D"
],
"text": [
"Leptin",
"Fructose",
"Glucose",
"Ghrelin"
]
} | sciknow_988c4cb8e0f9cbd8 | 5,425 | 20,260,428 | sciknoweval_v2_hard_autogradable_512_2026_04_28 | Biology_L2 | Biology | L2 | mcq-4-choices | C | |
{
"default": "Please read the text carefully and choose the correct answer from the multiple-choice options based on your understanding of the details or data described. Your answer should be \"A\", \"B\", \"C\" or \"D\". Please directly give the answer without any explanation."
} | In sexually reproducing organisms, each individual possesses two alleles for each gene, which are inherited from each parent. These alleles make up the individual's genotype, which in turn determines the phenotype, or physical appearance, of that organism. During the formation of gametes, a process governed by Mendel's... | mcq-4-choices | Biology | {
"level": "L2",
"source": "one.libretexts",
"subtask": "detailed_understanding",
"task": "L2_General"
} | C | {
"label": [
"A",
"B",
"C",
"D"
],
"text": [
"Each gamete receives two alleles from each gene pair.",
"Alleles for a single gene are sorted based on their dominant or recessive nature.",
"Each gamete receives one allele from each gene pair.",
"Alleles for different genes are inheri... | sciknow_65ce49c4fb1b9b3f | 5,426 | 20,260,428 | sciknoweval_v2_hard_autogradable_512_2026_04_28 | Biology_L2 | Biology | L2 | mcq-4-choices | C | |
{
"default": "The following is a text on biomedicine and a true or false question for this text. Your task is to analyze the provided text and give me the answer of the question. Your answer should be \"Yes\" or \"No\". Please directly give the answer, DO NOT output any other characters."
} | BACKGROUND: For the first time, models using multilevel analysis of Indian data and related simulation results are reported. They take hierarchical structure into account and incorporate variables from all levels to get correct analysis and proper interpretation of data on current contraceptive use (including steriliza... | Yes | true_or_false | Biology | {
"level": "L2",
"source": "one.libretexts",
"subtask": "biomedical_judgment_and_interpretation",
"task": "L2_Biology"
} | {
"label": [],
"text": []
} | sciknow_5da1932f901d1de9 | 4,022 | 20,260,428 | sciknoweval_v2_hard_autogradable_512_2026_04_28 | Biology_L2 | Biology | L2 | true_or_false | Yes | |
{
"default": "The following is a text on biomedicine and a true or false question for this text. Your task is to analyze the provided text and give me the answer of the question. Your answer should be \"Yes\" or \"No\". Please directly give the answer, DO NOT output any other characters."
} | METHODS: Randomized controlled animal study.
OBJECTIVE: Test the effectiveness of a single-strip demineralized bone matrix with hyaluronan and gelatin.
BACKGROUND: Demineralized bone matrix is widely used to augment spinal fusion, however, the effect of changing the physical characteristic and carrier is not known.
MET... | Yes | true_or_false | Biology | {
"level": "L2",
"source": "one.libretexts",
"subtask": "biomedical_judgment_and_interpretation",
"task": "L2_Biology"
} | {
"label": [],
"text": []
} | sciknow_ec21f2c53371f65f | 4,169 | 20,260,428 | sciknoweval_v2_hard_autogradable_512_2026_04_28 | Biology_L2 | Biology | L2 | true_or_false | Yes | |
{
"default": "The following is a text on biomedicine and a true or false question for this text. Your task is to analyze the provided text and give me the answer of the question. Your answer should be \"Yes\" or \"No\". Please directly give the answer, DO NOT output any other characters."
} | BACKGROUND: The purpose of present study was to examine the expression of cancer stem cell marker Bmi-1 in breast cancer tissue and to evaluate the clinical implication of Bmi-1 expression for these patients.
METHODS: A total of 171 breast cancer patients who received surgical treatment in our hospital were enrolled in... | Yes | true_or_false | Biology | {
"level": "L2",
"source": "one.libretexts",
"subtask": "biomedical_judgment_and_interpretation",
"task": "L2_Biology"
} | {
"label": [],
"text": []
} | sciknow_b0976ceca80cd472 | 4,193 | 20,260,428 | sciknoweval_v2_hard_autogradable_512_2026_04_28 | Biology_L2 | Biology | L2 | true_or_false | Yes | |
{
"default": "The following is a text on biomedicine and a true or false question for this text. Your task is to analyze the provided text and give me the answer of the question. Your answer should be \"Yes\" or \"No\". Please directly give the answer, DO NOT output any other characters."
} | BACKGROUND: Allergy to fresh fruits and vegetables is mostly observed in subjects with pollinosis, especially from birch, because of cross-reacting allergens in vegetable foods and pollens. However, allergic reactions to fruits, specifically Rosaceae fruits, have been reported in subjects without pollinosis.
OBJECTIVE:... | Yes | true_or_false | Biology | {
"level": "L2",
"source": "one.libretexts",
"subtask": "biomedical_judgment_and_interpretation",
"task": "L2_Biology"
} | {
"label": [],
"text": []
} | sciknow_f28ee17f08013e6a | 4,212 | 20,260,428 | sciknoweval_v2_hard_autogradable_512_2026_04_28 | Biology_L2 | Biology | L2 | true_or_false | Yes | |
{
"default": "The following is a text on biomedicine and a true or false question for this text. Your task is to analyze the provided text and give me the answer of the question. Your answer should be \"Yes\" or \"No\". Please directly give the answer, DO NOT output any other characters."
} | OBJECTIVE: Sex hormone status has been demonstrated to play a role in the regulation of ion channel activity. We previously demonstrated increased L-type Ca channel current (ICa) in coronary smooth muscle cells (SMCs) of male swine compared with female swine. In male swine, endogenous testosterone increases ICa in SMCs... | Yes | true_or_false | Biology | {
"level": "L2",
"source": "one.libretexts",
"subtask": "biomedical_judgment_and_interpretation",
"task": "L2_Biology"
} | {
"label": [],
"text": []
} | sciknow_db7706b4cdda4245 | 4,224 | 20,260,428 | sciknoweval_v2_hard_autogradable_512_2026_04_28 | Biology_L2 | Biology | L2 | true_or_false | Yes | |
{
"default": "The following is a text on biomedicine and a true or false question for this text. Your task is to analyze the provided text and give me the answer of the question. Your answer should be \"Yes\" or \"No\". Please directly give the answer, DO NOT output any other characters."
} | BACKGROUND: Which factors predict recurrence in patients with Crohn's disease in the era of immunosuppressive medications is still under debate.
OBJECTIVE: The current study was conducted to assess long-term outcome after ileocolic resection for Crohn's disease and to define predictive factors for surgical relapse.
MET... | Yes | true_or_false | Biology | {
"level": "L2",
"source": "one.libretexts",
"subtask": "biomedical_judgment_and_interpretation",
"task": "L2_Biology"
} | {
"label": [],
"text": []
} | sciknow_4ad36d6c7429a521 | 4,250 | 20,260,428 | sciknoweval_v2_hard_autogradable_512_2026_04_28 | Biology_L2 | Biology | L2 | true_or_false | Yes | |
{
"default": "The following is a text on biomedicine and a true or false question for this text. Your task is to analyze the provided text and give me the answer of the question. Your answer should be \"Yes\" or \"No\". Please directly give the answer, DO NOT output any other characters."
} | OBJECTIVE: The aim of this study was to evaluate the efficiency of cetuximab-based anti-EGFR treatment and Aurora kinase A / B knockdown as a function of Aurora kinase polymorphism in HNSCC cell lines.
METHODS: First, protein expression of Aurora kinase A / B and EGFR and Aurora kinase A polymorphism were studied in tu... | Yes | true_or_false | Biology | {
"level": "L2",
"source": "one.libretexts",
"subtask": "biomedical_judgment_and_interpretation",
"task": "L2_Biology"
} | {
"label": [],
"text": []
} | sciknow_e8ca1b5b04ca7992 | 4,291 | 20,260,428 | sciknoweval_v2_hard_autogradable_512_2026_04_28 | Biology_L2 | Biology | L2 | true_or_false | Yes | |
{
"default": "The following is a text on biomedicine and a true or false question for this text. Your task is to analyze the provided text and give me the answer of the question. Your answer should be \"Yes\" or \"No\". Please directly give the answer, DO NOT output any other characters."
} | OBJECTIVE: Severe acute radiation dermatitis is observed in approximately 5% to 10% of patients who receive whole-breast radiotherapy. Several factors, including treatment-related and patient-oriented factors, are involved in susceptibility to severe dermatitis. Genetic factors are also thought to be related to a patie... | Yes | true_or_false | Biology | {
"level": "L2",
"source": "one.libretexts",
"subtask": "biomedical_judgment_and_interpretation",
"task": "L2_Biology"
} | {
"label": [],
"text": []
} | sciknow_7230e5bfbf93d32e | 4,301 | 20,260,428 | sciknoweval_v2_hard_autogradable_512_2026_04_28 | Biology_L2 | Biology | L2 | true_or_false | Yes | |
{
"default": "The following is a text on biomedicine and a true or false question for this text. Your task is to analyze the provided text and give me the answer of the question. Your answer should be \"Yes\" or \"No\". Please directly give the answer, DO NOT output any other characters."
} | OBJECTIVE: Considering a causal role of androgens in thymic involution, age-related remodeling of peripheral T-cell compartments in the absence of testicular hormones was evaluated.
METHODS: Rats were orchidectomized (ORX) at the age of 1 month, and T-peripheral blood lymphocytes (PBLs) and splenocytes from young (75-d... | Yes | true_or_false | Biology | {
"level": "L2",
"source": "one.libretexts",
"subtask": "biomedical_judgment_and_interpretation",
"task": "L2_Biology"
} | {
"label": [],
"text": []
} | sciknow_2618ca36fb19b936 | 4,313 | 20,260,428 | sciknoweval_v2_hard_autogradable_512_2026_04_28 | Biology_L2 | Biology | L2 | true_or_false | Yes | |
{
"default": "The following is a text on biomedicine and a true or false question for this text. Your task is to analyze the provided text and give me the answer of the question. Your answer should be \"Yes\" or \"No\". Please directly give the answer, DO NOT output any other characters."
} | BACKGROUND: The direct examination of large, unbiased samples of young gene duplicates in their early stages of evolution is crucial to understanding the origin, divergence and preservation of new genes. Furthermore, comparative analysis of multiple genomes is necessary to determine whether patterns of gene duplication... | Yes | true_or_false | Biology | {
"level": "L2",
"source": "one.libretexts",
"subtask": "biomedical_judgment_and_interpretation",
"task": "L2_Biology"
} | {
"label": [],
"text": []
} | sciknow_24eb70772e2f09a2 | 4,404 | 20,260,428 | sciknoweval_v2_hard_autogradable_512_2026_04_28 | Biology_L2 | Biology | L2 | true_or_false | Yes | |
{
"default": "The following is a text on biomedicine and a true or false question for this text. Your task is to analyze the provided text and give me the answer of the question. Your answer should be \"Yes\" or \"No\". Please directly give the answer, DO NOT output any other characters."
} | BACKGROUND: Papillary thyroid cancer is the most common endocrine malignancy. The most sensitive and specific diagnostic tool for thyroid nodule diagnosis is fine-needle aspiration (FNA) biopsy with cytological evaluation. Nevertheless, FNA biopsy is not always decisive leading to "indeterminate" or "suspicious" diagno... | Yes | true_or_false | Biology | {
"level": "L2",
"source": "one.libretexts",
"subtask": "biomedical_judgment_and_interpretation",
"task": "L2_Biology"
} | {
"label": [],
"text": []
} | sciknow_9a4977552d6984b2 | 4,451 | 20,260,428 | sciknoweval_v2_hard_autogradable_512_2026_04_28 | Biology_L2 | Biology | L2 | true_or_false | Yes | |
{
"default": "You will be presented with a hypothesis or conjecture. Based on the information provided in a text excerpt or your general knowledge, determine if the hypothesis is true (yes) or false (no). Your answer should be \"Yes\" or \"No\". Please directly give the answer, DO NOT output any other characters."
} | During DNA replication in eukaryotic cells, the issue of potentially losing genetic information from the ends of chromosomes due to the inability to replicate the final segment of the lagging strand is addressed by the enzyme telomerase. This enzyme extends one of the two DNA strands by adding a sequence of DNA nucleot... | No | true_or_false | Biology | {
"level": "L2",
"source": "one.libretexts",
"subtask": "hypothesis_verification",
"task": "L2_General"
} | {
"label": [],
"text": []
} | sciknow_67fc03ab3534bbea | 5,466 | 20,260,428 | sciknoweval_v2_hard_autogradable_512_2026_04_28 | Biology_L2 | Biology | L2 | true_or_false | No | |
{
"default": "You will be presented with a hypothesis or conjecture. Based on the information provided in a text excerpt or your general knowledge, determine if the hypothesis is true (yes) or false (no). Your answer should be \"Yes\" or \"No\". Please directly give the answer, DO NOT output any other characters."
} | Transcription is the process where RNA is synthesized from a DNA template. In this process, the DNA strand partially unwinds to form a "bubble", and RNA polymerase, guided by regulatory protein complexes, attaches to the transcription start site (TSS). It reads the DNA from the 3’ to 5’ direction and lays down compleme... | No | true_or_false | Biology | {
"level": "L2",
"source": "one.libretexts",
"subtask": "hypothesis_verification",
"task": "L2_General"
} | {
"label": [],
"text": []
} | sciknow_7f2f273e0093e6d5 | 5,552 | 20,260,428 | sciknoweval_v2_hard_autogradable_512_2026_04_28 | Biology_L2 | Biology | L2 | true_or_false | No | |
{
"default": "You will be presented with a hypothesis or conjecture. Based on the information provided in a text excerpt or your general knowledge, determine if the hypothesis is true (yes) or false (no). Your answer should be \"Yes\" or \"No\". Please directly give the answer, DO NOT output any other characters."
} | Some expression vectors used in recombinant DNA technology incorporate proteins or peptide sequences that facilitate the purification of the expressed protein. Examples of these tags include polyhistidine-tag, glutathione-S-transferase, and maltose-binding protein, which not only aid in purification but may also enhanc... | No | true_or_false | Biology | {
"level": "L2",
"source": "one.libretexts",
"subtask": "hypothesis_verification",
"task": "L2_General"
} | {
"label": [],
"text": []
} | sciknow_886e5e263520db29 | 5,599 | 20,260,428 | sciknoweval_v2_hard_autogradable_512_2026_04_28 | Biology_L2 | Biology | L2 | true_or_false | No | |
{
"default": "You will be presented with a hypothesis or conjecture. Based on the information provided in a text excerpt or your general knowledge, determine if the hypothesis is true (yes) or false (no). Your answer should be \"Yes\" or \"No\". Please directly give the answer, DO NOT output any other characters."
} | Electron transfer to ferredoxin is induced by light, which then binds to ferredoxin NADP reductase, leading to the formation of NADPH. This process is crucial in photosynthesis. Additionally, increased levels of reduced ferredoxin contribute to the formation of reduced thioredoxin, a small redox protein that plays a ro... | No | true_or_false | Biology | {
"level": "L2",
"source": "one.libretexts",
"subtask": "hypothesis_verification",
"task": "L2_General"
} | {
"label": [],
"text": []
} | sciknow_5826cbc8f257b5c3 | 5,676 | 20,260,428 | sciknoweval_v2_hard_autogradable_512_2026_04_28 | Biology_L2 | Biology | L2 | true_or_false | No | |
{
"default": "You will be presented with a hypothesis or conjecture. Based on the information provided in a text excerpt or your general knowledge, determine if the hypothesis is true (yes) or false (no). Your answer should be \"Yes\" or \"No\". Please directly give the answer, DO NOT output any other characters."
} | In Southern blotting, probes, which are pieces of DNA designed to be complementary to a target sequence, are added to a membrane as labeled probes. If the target DNA sequence is present on the blot, the probe can hybridize with it through base-pairing. After hybridization, the blot is washed to remove any unbound probe... | Yes | true_or_false | Biology | {
"level": "L2",
"source": "one.libretexts",
"subtask": "hypothesis_verification",
"task": "L2_General"
} | {
"label": [],
"text": []
} | sciknow_182eb09d324cecaa | 5,688 | 20,260,428 | sciknoweval_v2_hard_autogradable_512_2026_04_28 | Biology_L2 | Biology | L2 | true_or_false | Yes | |
{
"default": "You will be presented with a hypothesis or conjecture. Based on the information provided in a text excerpt or your general knowledge, determine if the hypothesis is true (yes) or false (no). Your answer should be \"Yes\" or \"No\". Please directly give the answer, DO NOT output any other characters."
} | The text discusses the characteristics and mechanisms of eukaryotic origins of replication, contrasting them with those found in bacteria. Unlike in some yeasts where specific DNA sequences dictate the location of replication origins, in most eukaryotes, these locations are determined by factors such as the local DNA t... | No | true_or_false | Biology | {
"level": "L2",
"source": "one.libretexts",
"subtask": "hypothesis_verification",
"task": "L2_General"
} | {
"label": [],
"text": []
} | sciknow_fd58377eba969789 | 5,727 | 20,260,428 | sciknoweval_v2_hard_autogradable_512_2026_04_28 | Biology_L2 | Biology | L2 | true_or_false | No | |
{
"default": "Given a question and two options, please select the right answer. Your answer should be \"A\" or \"B\". Please directly give the answer without any explanation."
} | Given a protein from Aequorea victoria (avGFP), we measure the native function (fluorescence) of tens of thousands of derivative genotypes of avGFP. Please determine which of the following protein mutants has a higher fluorescence level? | mcq-2-choices | Biology | {
"level": "L3",
"source": "fluo",
"subtask": "fluorescence_prediction",
"task": "protein_function_prediction"
} | B | {
"label": [
"A",
"B"
],
"text": [
"SKGEELFTGVVPILVELDGVVNGHKFSVSGEGEGDATYGKLTLKFICTTGKLPVPWPTLVTTLSYGVQCFSRYPDHMKQHDFFKSAMPEGYVQERTIFFKDDGNYKTRAEAKFEGDTLVNRIELKGIDFKEDGNILGHKLEYNYNSHNVYIMADKQKNGIKVNFKIRHNIEDGSVQLADHYQQNTPIGDGPVLLPDNLYLSTQTALSKDPNEKRDHMVLLEFVTAAGITHGMDELK",
"SKGEELFTGVVPILVELDGDVN... | sciknow_d3cda2538558a64d | 5,870 | 20,260,428 | sciknoweval_v2_hard_autogradable_512_2026_04_28 | Biology_L3 | Biology | L3 | mcq-2-choices | B | |
{
"default": "Given a question and two options, please select the right answer. Your answer should be \"A\" or \"B\". Please directly give the answer without any explanation."
} | Given the extensive assay of avGFP derivative genotypes and their fluorescence, which of the following mutants demonstrates higher fluorescence, considering the impact of missense mutations on chromophore interaction? | mcq-2-choices | Biology | {
"level": "L3",
"source": "fluo",
"subtask": "fluorescence_prediction",
"task": "protein_function_prediction"
} | A | {
"label": [
"A",
"B"
],
"text": [
"SKGEELFTGVVPILVELDGDVNGHKFSVSGEGEGDATYGKLTLKFICTTGKLPVPWPTLVTTLSYGVQCFSRYPDHMKQHDFFKSAMPEGYVQERTIFFKDDGNNETRAEVKFEGDTLVNRIELKGVNFKEDGNILGHKLEYNYNSHNVYIMADKQKNGIKVSSKIRHNIEDGSVQLADHYQQNTPIGDGPVLLPDNHYLSTQSALSRDPNEKRDHMVLLEFVTAAGITHGMDELYK",
"SKGEELFTGVVPILVELDGDV... | sciknow_8c240c888d5558ed | 5,872 | 20,260,428 | sciknoweval_v2_hard_autogradable_512_2026_04_28 | Biology_L3 | Biology | L3 | mcq-2-choices | A | |
{
"default": "Given a question and two options, please select the right answer. Your answer should be \"A\" or \"B\". Please directly give the answer without any explanation."
} | Given a protein from Aequorea victoria (avGFP), we measure the native function (fluorescence) of tens of thousands of derivative genotypes of avGFP. which of the following mutant protein demonstrates greater fluorescence? | mcq-2-choices | Biology | {
"level": "L3",
"source": "fluo",
"subtask": "fluorescence_prediction",
"task": "protein_function_prediction"
} | A | {
"label": [
"A",
"B"
],
"text": [
"SKGEELFTGVVPILVELDGDVNGHKFSVSGEGEGDATYGKLTLKFICTTGKLPVPWPTLVTTLSYGVQCFSRYPDHMKQHDLFESAMPEGYAQERTFFFKDDGNYKTRAEVKFEGDTLVNRIELKGIDFKEDGNILGHMLEYNYNSHNVIMADEQKNGIKVNFKIRHNIEDGSVQLADHYQQNTPIGDGPVLLPDNHYLSTQSALSKDPNEKRDHMVLLEFVTAAGITHGMDELYK",
"SKGEELFTGVVPILVELDGDVN... | sciknow_fb78ab18bca123b9 | 5,873 | 20,260,428 | sciknoweval_v2_hard_autogradable_512_2026_04_28 | Biology_L3 | Biology | L3 | mcq-2-choices | A | |
{
"default": "Given a question and two options, please select the right answer. Your answer should be \"A\" or \"B\". Please directly give the answer without any explanation."
} | Given a protein from Aequorea victoria (avGFP), we measure the native function (fluorescence) of tens of thousands of derivative genotypes of avGFP. Please determine which of the following protein mutants has a higher fluorescence level? | mcq-2-choices | Biology | {
"level": "L3",
"source": "fluo",
"subtask": "fluorescence_prediction",
"task": "protein_function_prediction"
} | B | {
"label": [
"A",
"B"
],
"text": [
"SKGEELFTGVVPILVELDGDVNGHKFSVSGEGEGDATYGKLSLKFICTTGKLPVPWPTLVTTLSYGVQCFSRYPDHMKQHDFLKSATPEGYVQERTIFFKDDGNYKTRAEEKFEGDTLVNRIELKGIDFKEDGNILGHKLEYNYNSHNVYIMADKQRNGIKVNFKIRHNIEDGSVQLADHYQQNTPIGDGPVLLPDNHYLSTQSALSKDPNEKRDHMVLLEFVTAAGITHGMDELYK",
"SKGEELFTGVVPILVELDGDV... | sciknow_d3cda2538558a64d | 5,887 | 20,260,428 | sciknoweval_v2_hard_autogradable_512_2026_04_28 | Biology_L3 | Biology | L3 | mcq-2-choices | B | |
{
"default": "Given a question and two options, please select the right answer. Your answer should be \"A\" or \"B\". Please directly give the answer without any explanation."
} | Given a protein from Aequorea victoria (avGFP), we measure the native function (fluorescence) of tens of thousands of derivative genotypes of avGFP. Which of the following mutant is observed to have higher fluorescence levels? | mcq-2-choices | Biology | {
"level": "L3",
"source": "fluo",
"subtask": "fluorescence_prediction",
"task": "protein_function_prediction"
} | B | {
"label": [
"A",
"B"
],
"text": [
"SKGEELFTGVAPFLVELDGDVNGHKFSVSGEGEGDATYGKPTLKFICTTGKLPVPWPTLVTTLSYGVQCFSRYPDHMKQHDFFKSAMPEGYVQERTIFFKDDGNYKTRAEVEFEGDTLVNRIELKGIDFKEDGNILGHKLEYNYNSHNVYIMADKQKNGIKVNFKIRHNIEDGSVQLADHYQQNTPIGDGPVLLPDNHYLSTQSALSKDPNEKRDHMVLLEFVTAAGITHGMDELYK",
"SKGEELFTGVVPILVELDGDV... | sciknow_abb34a5c9c14840c | 5,895 | 20,260,428 | sciknoweval_v2_hard_autogradable_512_2026_04_28 | Biology_L3 | Biology | L3 | mcq-2-choices | B | |
{
"default": "Given a question and two options, please select the right answer. Your answer should be \"A\" or \"B\". Please directly give the answer without any explanation."
} | Given a protein from Aequorea victoria (avGFP), we measure the native function (fluorescence) of tens of thousands of derivative genotypes of avGFP. Which of the following mutant is observed to have higher fluorescence levels? | mcq-2-choices | Biology | {
"level": "L3",
"source": "fluo",
"subtask": "fluorescence_prediction",
"task": "protein_function_prediction"
} | B | {
"label": [
"A",
"B"
],
"text": [
"SKGEELFTGVVPILVELDGDVNGHKFSVSGEGEGDATYGKLTLKFICTTGKLPVPWPTLVTTLSYGVQRFSRYPDHMKQHDFFKSAMPEGYVQERTIFFKDDGNYKTRAEVKFEGDTLVNRIELKGIDFKEDGNFLGHKLEYDYNSHNVYIMADKQRNGIKVNFKIRHNIEDGSVQLADHYQQNTPIGDGPVLLPDNHYLSTQSALSKDPNEKRDHMVLLELVTAAGITHGMDELYK",
"SKGEELFTGVVPILVELDGDV... | sciknow_abb34a5c9c14840c | 5,908 | 20,260,428 | sciknoweval_v2_hard_autogradable_512_2026_04_28 | Biology_L3 | Biology | L3 | mcq-2-choices | B | |
{
"default": "Given a question and two options, please select the right answer. Your answer should be \"A\" or \"B\". Please directly give the answer without any explanation."
} | Given a protein from Aequorea victoria (avGFP), we measure the native function (fluorescence) of tens of thousands of derivative genotypes of avGFP. Please determine which of the following protein mutants shows enhanced fluorescence? | mcq-2-choices | Biology | {
"level": "L3",
"source": "fluo",
"subtask": "fluorescence_prediction",
"task": "protein_function_prediction"
} | B | {
"label": [
"A",
"B"
],
"text": [
"SKGEELFTGVVPILVELDGDVNGHKFSVSGEGEGDATYGKLTLKFICATGKLPVPRPTLVTTLSYGVQCFSRYPDHMKQHDSFKSAMPEGYVQERTIFFKDDGNYKTRAEVKFEGDTLVNRIELKGIDFKEDGNILGHKLEYNHNSHSVYIMADKQKNGIKVNFKIRHNIEDGSVQLADHYQQNTPIGDGRVLLPDNHYLSTQSALSKDPNEKRDHMVLLEFVTAAGITHGMDELYK",
"SKGEELFTGVVPILVELDGDV... | sciknow_320d5be76fd698f6 | 5,916 | 20,260,428 | sciknoweval_v2_hard_autogradable_512_2026_04_28 | Biology_L3 | Biology | L3 | mcq-2-choices | B | |
{
"default": "Given a question and two options, please select the right answer. Your answer should be \"A\" or \"B\". Please directly give the answer without any explanation."
} | Given a protein from Aequorea victoria (avGFP), we measure the native function (fluorescence) of tens of thousands of derivative genotypes of avGFP. Which of the following mutant is observed to have higher fluorescence levels? | mcq-2-choices | Biology | {
"level": "L3",
"source": "fluo",
"subtask": "fluorescence_prediction",
"task": "protein_function_prediction"
} | A | {
"label": [
"A",
"B"
],
"text": [
"SKGEELFTGVVPILVELDGDVNGHKFSVSGEGEGDATYGKLTLKFICTTGKLPVPWPTLVTTLSYGVQCFSHYPDHMKQHDFFKSAMPEGYVQERTIFFKDDGNYKTRAVVKFEGDTLVNRIELKGIDFKEDGNILGHKLEYNYNSHNVYIMADKQKNGIKVNFKIRHNIEDGSARLADHYQQNTPIGDGPVLLPDNPYLSTQSALSKDPNEKRDHMVLLEFVTAAGIIHGMDELYK",
"SKGEELFTGVVPILVELDGDV... | sciknow_0d306ed5035029e7 | 5,921 | 20,260,428 | sciknoweval_v2_hard_autogradable_512_2026_04_28 | Biology_L3 | Biology | L3 | mcq-2-choices | A | |
{
"default": "Given a question and two options, please select the right answer. Your answer should be \"A\" or \"B\". Please directly give the answer without any explanation."
} | Given a protein from Aequorea victoria (avGFP), we measure the native function (fluorescence) of tens of thousands of derivative genotypes of avGFP. Please determine which of the following protein mutants shows enhanced fluorescence? | mcq-2-choices | Biology | {
"level": "L3",
"source": "fluo",
"subtask": "fluorescence_prediction",
"task": "protein_function_prediction"
} | A | {
"label": [
"A",
"B"
],
"text": [
"SKGEELFTGVVPILVELDGDVNGHKFGVSGEGEGDATYGKLTLKFICTTGKLPVPWPTLVTTLSYGVQCFSRYPDHMKQHDFFKSAMPEGYVQERTIFFKDDGNYKTRAEVKFEGDTLVNRIELKGIDFKEDGNILGHKLEYNYNSHNVYIMADRQKNGIKVNFKIRHNIEDGSVQLAGRYQQNTPIGDGPVLLPDNHYLSTQSALSKDPNEKRDHMVLPEFVTAAGITHGMDELYK",
"SKGEELFTGVVPILVELDGDV... | sciknow_385b27744f41cbd1 | 5,932 | 20,260,428 | sciknoweval_v2_hard_autogradable_512_2026_04_28 | Biology_L3 | Biology | L3 | mcq-2-choices | A | |
{
"default": "Given a question and two options, please select the right answer. Your answer should be \"A\" or \"B\". Please directly give the answer without any explanation."
} | Given a protein from Aequorea victoria (avGFP), we measure the native function (fluorescence) of tens of thousands of derivative genotypes of avGFP. Please determine which of the following protein mutants shows enhanced fluorescence? | mcq-2-choices | Biology | {
"level": "L3",
"source": "fluo",
"subtask": "fluorescence_prediction",
"task": "protein_function_prediction"
} | B | {
"label": [
"A",
"B"
],
"text": [
"SKGEELFTGVVPILVELDGDVNGHKFSVSGEGEGDATYGKLTLKFICTTGKLPVPWPTLVTTLSYGVQCFSRYPDHMKQHDFFGSAMPEGYVQERTIFFKDDGNFKTRAEVKFEGDTLVNRIELKGIDFKEDGNFLGHKLEYNYNSHNVYIMADKQKNGIKVNFKNRHNIEDGSVQLADHYQQNTPNGDGPVLLPDNHYLSTQSALSKDPNEKRDHMVLLEFVTAAGITHGVDELYK",
"SKGEELFTGVVPILVELDGDV... | sciknow_320d5be76fd698f6 | 5,960 | 20,260,428 | sciknoweval_v2_hard_autogradable_512_2026_04_28 | Biology_L3 | Biology | L3 | mcq-2-choices | B | |
{
"default": "Given a question and two options, please select the right answer. Your answer should be \"A\" or \"B\". Please directly give the answer without any explanation."
} | TEM-1 beta-lactamase is the most widespread enzyme that endows gram-negative bacteria with beta-lactam antibiotic resistance. beta-lactamase activity prediction studies the activity among first-order mutants of the TEM-1 betalactamase protein. Please determine which of the following protein mutants has higher beta-lact... | mcq-2-choices | Biology | {
"level": "L3",
"source": "beta_lactamase",
"subtask": "beta_lactamase_activity_prediction",
"task": "protein_function_prediction"
} | A | {
"label": [
"A",
"B"
],
"text": [
"MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQA... | sciknow_299300ba3d86088f | 6,067 | 20,260,428 | sciknoweval_v2_hard_autogradable_512_2026_04_28 | Biology_L3 | Biology | L3 | mcq-2-choices | A | |
{
"default": "Given a question and two options, please select the right answer. Your answer should be \"A\" or \"B\". Please directly give the answer without any explanation."
} | TEM-1 beta-lactamase is the most widespread enzyme that endows gram-negative bacteria with beta-lactam antibiotic resistance. beta-lactamase activity prediction studies the activity among first-order mutants of the TEM-1 betalactamase protein. Please determine which of the following protein mutants has higher beta-lact... | mcq-2-choices | Biology | {
"level": "L3",
"source": "beta_lactamase",
"subtask": "beta_lactamase_activity_prediction",
"task": "protein_function_prediction"
} | B | {
"label": [
"A",
"B"
],
"text": [
"MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQDGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQA... | sciknow_411aa55311ae340f | 6,076 | 20,260,428 | sciknoweval_v2_hard_autogradable_512_2026_04_28 | Biology_L3 | Biology | L3 | mcq-2-choices | B | |
{
"default": "Given a question and two options, please select the right answer. Your answer should be \"A\" or \"B\". Please directly give the answer without any explanation."
} | TEM-1 beta-lactamase is the most widespread enzyme that endows gram-negative bacteria with beta-lactam antibiotic resistance. beta-lactamase activity prediction studies the activity among first-order mutants of the TEM-1 betalactamase protein. Please determine which of the following protein mutants has higher beta-lact... | mcq-2-choices | Biology | {
"level": "L3",
"source": "beta_lactamase",
"subtask": "beta_lactamase_activity_prediction",
"task": "protein_function_prediction"
} | B | {
"label": [
"A",
"B"
],
"text": [
"MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAELSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQA... | sciknow_411aa55311ae340f | 6,123 | 20,260,428 | sciknoweval_v2_hard_autogradable_512_2026_04_28 | Biology_L3 | Biology | L3 | mcq-2-choices | B | |
{
"default": "Given a question and two options, please select the right answer. Your answer should be \"A\" or \"B\". Please directly give the answer without any explanation."
} | TEM-1 beta-lactamase is the most widespread enzyme that endows gram-negative bacteria with beta-lactam antibiotic resistance. beta-lactamase activity prediction studies the activity among first-order mutants of the TEM-1 betalactamase protein. Please determine which of the following protein mutants has higher beta-lact... | mcq-2-choices | Biology | {
"level": "L3",
"source": "beta_lactamase",
"subtask": "beta_lactamase_activity_prediction",
"task": "protein_function_prediction"
} | B | {
"label": [
"A",
"B"
],
"text": [
"MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILVSFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQA... | sciknow_411aa55311ae340f | 6,131 | 20,260,428 | sciknoweval_v2_hard_autogradable_512_2026_04_28 | Biology_L3 | Biology | L3 | mcq-2-choices | B | |
{
"default": "Given a question and two options, please select the right answer. Your answer should be \"A\" or \"B\". Please directly give the answer without any explanation."
} | TEM-1 beta-lactamase is the most widespread enzyme that endows gram-negative bacteria with beta-lactam antibiotic resistance. beta-lactamase activity prediction studies the activity among first-order mutants of the TEM-1 betalactamase protein. Please determine which of the following protein mutants has higher beta-lact... | mcq-2-choices | Biology | {
"level": "L3",
"source": "beta_lactamase",
"subtask": "beta_lactamase_activity_prediction",
"task": "protein_function_prediction"
} | B | {
"label": [
"A",
"B"
],
"text": [
"MSIQHFRVALIPFFAAFCLPVFRHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQA... | sciknow_411aa55311ae340f | 6,138 | 20,260,428 | sciknoweval_v2_hard_autogradable_512_2026_04_28 | Biology_L3 | Biology | L3 | mcq-2-choices | B | |
{
"default": "Given a question and two options, please select the right answer. Your answer should be \"A\" or \"B\". Please directly give the answer without any explanation."
} | TEM-1 beta-lactamase is the most widespread enzyme that endows gram-negative bacteria with beta-lactam antibiotic resistance. beta-lactamase activity prediction studies the activity among first-order mutants of the TEM-1 betalactamase protein. Please determine which of the following protein mutants has higher beta-lact... | mcq-2-choices | Biology | {
"level": "L3",
"source": "beta_lactamase",
"subtask": "beta_lactamase_activity_prediction",
"task": "protein_function_prediction"
} | A | {
"label": [
"A",
"B"
],
"text": [
"MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEKDKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQA... | sciknow_299300ba3d86088f | 6,145 | 20,260,428 | sciknoweval_v2_hard_autogradable_512_2026_04_28 | Biology_L3 | Biology | L3 | mcq-2-choices | A | |
{
"default": "Given a question and two options, please select the right answer. Your answer should be \"A\" or \"B\". Please directly give the answer without any explanation."
} | TEM-1 beta-lactamase is the most widespread enzyme that endows gram-negative bacteria with beta-lactam antibiotic resistance. beta-lactamase activity prediction studies the activity among first-order mutants of the TEM-1 betalactamase protein. Please determine which of the following protein mutants has higher beta-lact... | mcq-2-choices | Biology | {
"level": "L3",
"source": "beta_lactamase",
"subtask": "beta_lactamase_activity_prediction",
"task": "protein_function_prediction"
} | A | {
"label": [
"A",
"B"
],
"text": [
"MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPRLNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQA... | sciknow_299300ba3d86088f | 6,158 | 20,260,428 | sciknoweval_v2_hard_autogradable_512_2026_04_28 | Biology_L3 | Biology | L3 | mcq-2-choices | A | |
{
"default": "Given a question and four options, please select the right answer. Your answer should be \"A\", \"B\", \"C\" or \"D\". Please directly give the answer without any explanation."
} | Starting with the wide-type protein sequence 'MQYKLILNGKTLKGETTTEAVDAATAEKVFKQYANDNGVDGEWTYDDATKTFTVTE', which exhibits a fitness of 1.0, we have created a mutant 'MQYKLILNGKTLKGETTTEAVDAATAEKVFKQYANDNGHQTEWTYDDATKTFTLTE' via a four-sites random mutation. Could you tell me the new fitness score of this mutant? Here the... | mcq-4-choices | Biology | {
"level": "L3",
"source": "GB1",
"subtask": "GB1_ftness_prediction",
"task": "protein_function_prediction"
} | D | {
"label": [
"A",
"B",
"C",
"D"
],
"text": [
"0.0",
"0.993",
"0.01",
"0.005"
]
} | sciknow_e513eb6574fa6d43 | 5,771 | 20,260,428 | sciknoweval_v2_hard_autogradable_512_2026_04_28 | Biology_L3 | Biology | L3 | mcq-4-choices | D | |
{
"default": "Given a question and four options, please select the right answer. Your answer should be \"A\", \"B\", \"C\" or \"D\". Please directly give the answer without any explanation."
} | We start with a wide-type protein sequence 'MQYKLILNGKTLKGETTTEAVDAATAEKVFKQYANDNGVDGEWTYDDATKTFTVTE' having a fitness of 1.0, here the fitness is determined by both stability (i.e. the fraction of folded proteins) and function (i.e. binding affinity to IgG-Fc receptors). After implementing a four-sites random mutation... | mcq-4-choices | Biology | {
"level": "L3",
"source": "GB1",
"subtask": "GB1_ftness_prediction",
"task": "protein_function_prediction"
} | A | {
"label": [
"A",
"B",
"C",
"D"
],
"text": [
"0.003",
"0.0",
"0.013",
"1.349"
]
} | sciknow_1d6c15a7bb40401f | 5,788 | 20,260,428 | sciknoweval_v2_hard_autogradable_512_2026_04_28 | Biology_L3 | Biology | L3 | mcq-4-choices | A | |
{
"default": "Given a question and four options, please select the right answer. Your answer should be \"A\", \"B\", \"C\" or \"D\". Please directly give the answer without any explanation."
} | Given the wide-type protein sequence 'MQYKLILNGKTLKGETTTEAVDAATAEKVFKQYANDNGVDGEWTYDDATKTFTVTE' with an initial fitness of 1.0, we have performed a four-sites random mutation resulting in the mutant 'MQYKLILNGKTLKGETTTEAVDAATAEKVFKQYANDNGCHFEWTYDDATKTFTATE'. Here the fitness is determined by both stability (i.e. the fr... | mcq-4-choices | Biology | {
"level": "L3",
"source": "GB1",
"subtask": "GB1_ftness_prediction",
"task": "protein_function_prediction"
} | D | {
"label": [
"A",
"B",
"C",
"D"
],
"text": [
"0.001",
"0.0",
"0.285",
"1.347"
]
} | sciknow_87f6c71b13754338 | 5,810 | 20,260,428 | sciknoweval_v2_hard_autogradable_512_2026_04_28 | Biology_L3 | Biology | L3 | mcq-4-choices | D | |
{
"default": "Given a question and four options, please select the right answer. Your answer should be \"A\", \"B\", \"C\" or \"D\". Please directly give the answer without any explanation."
} | Starting with the wide-type protein sequence 'MQYKLILNGKTLKGETTTEAVDAATAEKVFKQYANDNGVDGEWTYDDATKTFTVTE', which exhibits a fitness of 1.0, we have created a mutant 'MQYKLILNGKTLKGETTTEAVDAATAEKVFKQYANDNGDRMEWTYDDATKTFTFTE' via a four-sites random mutation. Could you tell me the new fitness score of this mutant? Here the... | mcq-4-choices | Biology | {
"level": "L3",
"source": "GB1",
"subtask": "GB1_ftness_prediction",
"task": "protein_function_prediction"
} | C | {
"label": [
"A",
"B",
"C",
"D"
],
"text": [
"0.0",
"0.118",
"0.007",
"0.015"
]
} | sciknow_a9d00fa0bdc51d98 | 5,821 | 20,260,428 | sciknoweval_v2_hard_autogradable_512_2026_04_28 | Biology_L3 | Biology | L3 | mcq-4-choices | C | |
{
"default": "Given a question and four options, please select the right answer. Your answer should be \"A\", \"B\", \"C\" or \"D\". Please directly give the answer without any explanation."
} | Starting with the wide-type protein sequence 'MQYKLILNGKTLKGETTTEAVDAATAEKVFKQYANDNGVDGEWTYDDATKTFTVTE', which exhibits a fitness of 1.0, we have created a mutant 'MQYKLILNGKTLKGETTTEAVDAATAEKVFKQYANDNGVFREWTYDDATKTFTVTE' via a four-sites random mutation. Could you tell me the new fitness score of this mutant? Here the... | mcq-4-choices | Biology | {
"level": "L3",
"source": "GB1",
"subtask": "GB1_ftness_prediction",
"task": "protein_function_prediction"
} | A | {
"label": [
"A",
"B",
"C",
"D"
],
"text": [
"0.004",
"1.319",
"0.012",
"0.0"
]
} | sciknow_2d3a0cea8b122b41 | 5,822 | 20,260,428 | sciknoweval_v2_hard_autogradable_512_2026_04_28 | Biology_L3 | Biology | L3 | mcq-4-choices | A | |
{
"default": "Given a question and four options, please select the right answer. Your answer should be \"A\", \"B\", \"C\" or \"D\". Please directly give the answer without any explanation."
} | The fitness of the wide-type protein sequence 'MQYKLILNGKTLKGETTTEAVDAATAEKVFKQYANDNGVDGEWTYDDATKTFTVTE' is 1.0, here the fitness is determined by both stability (i.e. the fraction of folded proteins) and function (i.e. binding affinity to IgG-Fc receptors). After a four-sites random mutation, the sequence evolves into... | mcq-4-choices | Biology | {
"level": "L3",
"source": "GB1",
"subtask": "GB1_ftness_prediction",
"task": "protein_function_prediction"
} | A | {
"label": [
"A",
"B",
"C",
"D"
],
"text": [
"0.004",
"0.0",
"0.68",
"0.058"
]
} | sciknow_38afeb8b0206918a | 5,839 | 20,260,428 | sciknoweval_v2_hard_autogradable_512_2026_04_28 | Biology_L3 | Biology | L3 | mcq-4-choices | A | |
{
"default": "Given a question and four options, please select the right answer. Your answer should be \"A\", \"B\", \"C\" or \"D\". Please directly give the answer without any explanation."
} | Considering the wide-type protein sequence 'MQYKLILNGKTLKGETTTEAVDAATAEKVFKQYANDNGVDGEWTYDDATKTFTVTE' with a fitness rating of 1.0, here the fitness is determined by both stability (i.e. the fraction of folded proteins) and function (i.e. binding affinity to IgG-Fc receptors). We introduced a four-sites random mutation... | mcq-4-choices | Biology | {
"level": "L3",
"source": "GB1",
"subtask": "GB1_ftness_prediction",
"task": "protein_function_prediction"
} | A | {
"label": [
"A",
"B",
"C",
"D"
],
"text": [
"0.005",
"0.0",
"0.012",
"0.205"
]
} | sciknow_1a48b690d8162a67 | 5,842 | 20,260,428 | sciknoweval_v2_hard_autogradable_512_2026_04_28 | Biology_L3 | Biology | L3 | mcq-4-choices | A | |
{
"default": "Given a question and four options, please select the right answer. Your answer should be \"A\", \"B\", \"C\" or \"D\". Please directly give the answer without any explanation."
} | The original wide-type protein sequence 'MQYKLILNGKTLKGETTTEAVDAATAEKVFKQYANDNGVDGEWTYDDATKTFTVTE' has a fitness of 1.0, here the fitness is determined by both stability (i.e. the fraction of folded proteins) and function (i.e. binding affinity to IgG-Fc receptors). Following a four-sites random mutation that results i... | mcq-4-choices | Biology | {
"level": "L3",
"source": "GB1",
"subtask": "GB1_ftness_prediction",
"task": "protein_function_prediction"
} | C | {
"label": [
"A",
"B",
"C",
"D"
],
"text": [
"0.025",
"0.208",
"0.001",
"0.0"
]
} | sciknow_71853e574bfd1e76 | 5,859 | 20,260,428 | sciknoweval_v2_hard_autogradable_512_2026_04_28 | Biology_L3 | Biology | L3 | mcq-4-choices | C | |
{
"default": "Given a question and four options, please select the right answer. Your answer should be \"A\", \"B\", \"C\" or \"D\". Please directly give the answer without any explanation."
} | Starting with the wide-type protein sequence 'MQYKLILNGKTLKGETTTEAVDAATAEKVFKQYANDNGVDGEWTYDDATKTFTVTE', which exhibits a fitness of 1.0, we have created a mutant 'MQYKLILNGKTLKGETTTEAVDAATAEKVFKQYANDNGCELEWTYDDATKTFTDTE' via a four-sites random mutation. Could you tell me the new fitness score of this mutant? Here the... | mcq-4-choices | Biology | {
"level": "L3",
"source": "GB1",
"subtask": "GB1_ftness_prediction",
"task": "protein_function_prediction"
} | A | {
"label": [
"A",
"B",
"C",
"D"
],
"text": [
"0.025",
"2.053",
"0.0",
"0.008"
]
} | sciknow_9bf6866d6c991ed8 | 5,862 | 20,260,428 | sciknoweval_v2_hard_autogradable_512_2026_04_28 | Biology_L3 | Biology | L3 | mcq-4-choices | A | |
{
"default": "Given a question and four options, please select the right answer. Your answer should be \"A\", \"B\", \"C\" or \"D\". Please directly give the answer without any explanation."
} | Considering the wide-type protein sequence 'MQYKLILNGKTLKGETTTEAVDAATAEKVFKQYANDNGVDGEWTYDDATKTFTVTE' with a fitness rating of 1.0, here the fitness is determined by both stability (i.e. the fraction of folded proteins) and function (i.e. binding affinity to IgG-Fc receptors). We introduced a four-sites random mutation... | mcq-4-choices | Biology | {
"level": "L3",
"source": "GB1",
"subtask": "GB1_ftness_prediction",
"task": "protein_function_prediction"
} | B | {
"label": [
"A",
"B",
"C",
"D"
],
"text": [
"0.212",
"0.011",
"0.002",
"0.0"
]
} | sciknow_544bdb1ac00f6a11 | 5,863 | 20,260,428 | sciknoweval_v2_hard_autogradable_512_2026_04_28 | Biology_L3 | Biology | L3 | mcq-4-choices | B | |
{
"default": "Given a question and four options, please select the right answer. Your answer should be \"A\", \"B\", \"C\" or \"D\". Please directly give the answer without any explanation."
} | What is the relationship between protein ENSP00000223324 and protein ENSP00000285298? | mcq-4-choices | Biology | {
"level": "L3",
"source": "STRING",
"subtask": "Protein_Protein_Interaction",
"task": "protein_function_prediction"
} | B | {
"label": [
"A",
"B",
"C",
"D"
],
"text": [
"The relation is ptmod.",
"The relation is reaction.",
"The relation is expression.",
"The relation is activation."
]
} | sciknow_10503b28c44bcdb1 | 6,193 | 20,260,428 | sciknoweval_v2_hard_autogradable_512_2026_04_28 | Biology_L3 | Biology | L3 | mcq-4-choices | B | |
{
"default": "Given a question and four options, please select the right answer. Your answer should be \"A\", \"B\", \"C\" or \"D\". Please directly give the answer without any explanation."
} | What is the relationship between protein ENSP00000278319 and protein ENSP00000354588? | mcq-4-choices | Biology | {
"level": "L3",
"source": "STRING",
"subtask": "Protein_Protein_Interaction",
"task": "protein_function_prediction"
} | D | {
"label": [
"A",
"B",
"C",
"D"
],
"text": [
"The relation is inhibition.",
"The relation is expression.",
"The relation is reaction.",
"The relation is binding."
]
} | sciknow_d2553b63c7eb6714 | 6,199 | 20,260,428 | sciknoweval_v2_hard_autogradable_512_2026_04_28 | Biology_L3 | Biology | L3 | mcq-4-choices | D | |
{
"default": "Given a question and four options, please select the right answer. Your answer should be \"A\", \"B\", \"C\" or \"D\". Please directly give the answer without any explanation."
} | What is the relationship between protein ENSP00000166244 and protein ENSP00000215659? | mcq-4-choices | Biology | {
"level": "L3",
"source": "SHS27K",
"subtask": "Protein_Protein_Interaction",
"task": "protein_function_prediction"
} | A | {
"label": [
"A",
"B",
"C",
"D"
],
"text": [
"The relation is reaction.",
"The relation is activation.",
"The relation is catalysis.",
"The relation is binding."
]
} | sciknow_c08b985c6f1ddb81 | 6,205 | 20,260,428 | sciknoweval_v2_hard_autogradable_512_2026_04_28 | Biology_L3 | Biology | L3 | mcq-4-choices | A | |
{
"default": "Given a question and four options, please select the right answer. Your answer should be \"A\", \"B\", \"C\" or \"D\". Please directly give the answer without any explanation."
} | What is the relationship between protein ENSP00000456213 and protein ENSP00000276072? | mcq-4-choices | Biology | {
"level": "L3",
"source": "STRING",
"subtask": "Protein_Protein_Interaction",
"task": "protein_function_prediction"
} | A | {
"label": [
"A",
"B",
"C",
"D"
],
"text": [
"The relation is binding.",
"The relation is reaction.",
"The relation is activation.",
"The relation is inhibition."
]
} | sciknow_7372bb721c6f7bb2 | 6,210 | 20,260,428 | sciknoweval_v2_hard_autogradable_512_2026_04_28 | Biology_L3 | Biology | L3 | mcq-4-choices | A | |
{
"default": "Given a question and four options, please select the right answer. Your answer should be \"A\", \"B\", \"C\" or \"D\". Please directly give the answer without any explanation."
} | What is the relationship between protein ENSP00000293275 and protein ENSP00000232564? | mcq-4-choices | Biology | {
"level": "L3",
"source": "STRING",
"subtask": "Protein_Protein_Interaction",
"task": "protein_function_prediction"
} | B | {
"label": [
"A",
"B",
"C",
"D"
],
"text": [
"The relation is post-translational.",
"The relation is reaction.",
"The relation is inhibition.",
"The relation is binding."
]
} | sciknow_02ffe6874a08c686 | 6,224 | 20,260,428 | sciknoweval_v2_hard_autogradable_512_2026_04_28 | Biology_L3 | Biology | L3 | mcq-4-choices | B | |
{
"default": "Given a question and four options, please select the right answer. Your answer should be \"A\", \"B\", \"C\" or \"D\". Please directly give the answer without any explanation."
} | What is the relationship between protein ENSP00000292303 and protein ENSP00000216629? | mcq-4-choices | Biology | {
"level": "L3",
"source": "SHS148K",
"subtask": "Protein_Protein_Interaction",
"task": "protein_function_prediction"
} | C | {
"label": [
"A",
"B",
"C",
"D"
],
"text": [
"The relation is inhibition.",
"The relation is post-translational.",
"The relation is reaction.",
"The relation is expression."
]
} | sciknow_5f4088dffdd49a7e | 6,261 | 20,260,428 | sciknoweval_v2_hard_autogradable_512_2026_04_28 | Biology_L3 | Biology | L3 | mcq-4-choices | C | |
{
"default": "Given a question and four options, please select the right answer. Your answer should be \"A\", \"B\", \"C\" or \"D\". Please directly give the answer without any explanation."
} | Select the correct folding stability score that matches with the protein sequence 'TTIKVNGQEYTVPLSPEQAAKAAKKRWPDYEVQIHGNTVKVTS'. | mcq-4-choices | Biology | {
"level": "L3",
"source": "stability",
"subtask": "stability_prediction",
"task": "protein_function_prediction"
} | D | {
"label": [
"A",
"B",
"C",
"D"
],
"text": [
"0.49",
"1.0",
"-0.04",
"0.8"
]
} | sciknow_2bb0cdd5ffa7eb02 | 6,267 | 20,260,428 | sciknoweval_v2_hard_autogradable_512_2026_04_28 | Biology_L3 | Biology | L3 | mcq-4-choices | D | |
{
"default": "Given a question and four options, please select the right answer. Your answer should be \"A\", \"B\", \"C\" or \"D\". Please directly give the answer without any explanation."
} | Select the correct folding stability score that matches with the protein sequence 'GTLHLNGVTVKVPSLEAAIKAAKKFAKKYNLEVQVHGNTVHVH'. | mcq-4-choices | Biology | {
"level": "L3",
"source": "stability",
"subtask": "stability_prediction",
"task": "protein_function_prediction"
} | B | {
"label": [
"A",
"B",
"C",
"D"
],
"text": [
"-0.1",
"1.13",
"0.32",
"1.57"
]
} | sciknow_edb38fb5273cc521 | 6,268 | 20,260,428 | sciknoweval_v2_hard_autogradable_512_2026_04_28 | Biology_L3 | Biology | L3 | mcq-4-choices | B | |
{
"default": "Given a question and four options, please select the right answer. Your answer should be \"A\", \"B\", \"C\" or \"D\". Please directly give the answer without any explanation."
} | Given the protein sequence 'TWQGLVKIAEKALEKGEPITINGITVTTKEQAKQAIEYLKKAY', can you determine its folding stability score? | mcq-4-choices | Biology | {
"level": "L3",
"source": "stability",
"subtask": "stability_prediction",
"task": "protein_function_prediction"
} | A | {
"label": [
"A",
"B",
"C",
"D"
],
"text": [
"0.64",
"-0.04",
"0.23",
"2.04"
]
} | sciknow_cf895e323b660e05 | 6,281 | 20,260,428 | sciknoweval_v2_hard_autogradable_512_2026_04_28 | Biology_L3 | Biology | L3 | mcq-4-choices | A | |
{
"default": "Given a question and four options, please select the right answer. Your answer should be \"A\", \"B\", \"C\" or \"D\". Please directly give the answer without any explanation."
} | For the protein sequence 'TLDEARELVERAKKEGTGVDVNGQRFEYWREAERWVREQEKNK', what is the appropriate folding stability score? | mcq-4-choices | Biology | {
"level": "L3",
"source": "stability",
"subtask": "stability_prediction",
"task": "protein_function_prediction"
} | D | {
"label": [
"A",
"B",
"C",
"D"
],
"text": [
"-0.03",
"2.2",
"1.69",
"0.27"
]
} | sciknow_ba91572c92d1e8f5 | 6,308 | 20,260,428 | sciknoweval_v2_hard_autogradable_512_2026_04_28 | Biology_L3 | Biology | L3 | mcq-4-choices | D | |
{
"default": "Given a question and four options, please select the right answer. Your answer should be \"A\", \"B\", \"C\" or \"D\". Please directly give the answer without any explanation."
} | Select the correct folding stability score that matches with the protein sequence 'TELKKKLEEALKKVEEVRVKFNGIEIRITSEDAARKAVELLEK'. | mcq-4-choices | Biology | {
"level": "L3",
"source": "stability",
"subtask": "stability_prediction",
"task": "protein_function_prediction"
} | C | {
"label": [
"A",
"B",
"C",
"D"
],
"text": [
"1.74",
"-0.13",
"0.82",
"0.15"
]
} | sciknow_e6407d92adbdeae1 | 6,329 | 20,260,428 | sciknoweval_v2_hard_autogradable_512_2026_04_28 | Biology_L3 | Biology | L3 | mcq-4-choices | C | |
{
"default": "Given a question and four options, please select the right answer. Your answer should be \"A\", \"B\", \"C\" or \"D\". Please directly give the answer without any explanation."
} | Find the correct folding correct stability score for the protein sequence 'ERRKIEEIAKKLYQSFNPEAARRFLRKAGISEEEIERILQKAG'. | mcq-4-choices | Biology | {
"level": "L3",
"source": "stability",
"subtask": "stability_prediction",
"task": "protein_function_prediction"
} | B | {
"label": [
"A",
"B",
"C",
"D"
],
"text": [
"-0.07",
"1.59",
"1.11",
"0.89"
]
} | sciknow_2d1e1fea2a2712fd | 6,342 | 20,260,428 | sciknoweval_v2_hard_autogradable_512_2026_04_28 | Biology_L3 | Biology | L3 | mcq-4-choices | B | |
{
"default": "Given a question and four options, please select the right answer. Your answer should be \"A\", \"B\", \"C\" or \"D\". Please directly give the answer without any explanation."
} | Select the correct folding stability score that matches with the protein sequence 'TTIKVNGQEYTVPLSPEQAAKAAKKRWPDYEVQIHQNTVKVTR'. | mcq-4-choices | Biology | {
"level": "L3",
"source": "stability",
"subtask": "stability_prediction",
"task": "protein_function_prediction"
} | A | {
"label": [
"A",
"B",
"C",
"D"
],
"text": [
"0.65",
"1.33",
"0.25",
"1.72"
]
} | sciknow_d9007b557f2db5b7 | 6,355 | 20,260,428 | sciknoweval_v2_hard_autogradable_512_2026_04_28 | Biology_L3 | Biology | L3 | mcq-4-choices | A | |
{
"default": "Given a true or false question, your task is to answer whether the question is true or not. Your answer should be \"Yes\" or \"No\". Please directly give the answer, DO NOT output any other characters."
} | Is water solubility expected for the protein 'MKIFNTIQSVLFAAFFLKQGNCLASNGSTALMGEVDMQTPFPEWLTEFTNLTQWPGIDPPYIPLDYINLTEVPELDRYYPGQCPKISREQCSFDCYNCIDVDDVTSCFKLSQTFDDGPAPATEALLKKLRQRTTFFVLGINTVNYPDIYEHILERGHLIGTHTWSHEFLPSLSNEEIVAQIEWSIWAMNATGKHFPKYFRPPYGAIDNRVRAIVKQFGLTVVLWDLDTFDWKLITNDDFRTEEEILMDINTWKGKRKGLILEHDGARRTVEVAI... | No | true_or_false | Biology | {
"level": "L3",
"source": "solubility",
"subtask": "solubility_prediction",
"task": "protein_function_prediction"
} | {
"label": [],
"text": []
} | sciknow_4190a8ae631247ba | 5,964 | 20,260,428 | sciknoweval_v2_hard_autogradable_512_2026_04_28 | Biology_L3 | Biology | L3 | true_or_false | No | |
{
"default": "Given a true or false question, your task is to answer whether the question is true or not. Your answer should be \"Yes\" or \"No\". Please directly give the answer, DO NOT output any other characters."
} | Is it possible for the sequence 'MWLSKFQFPSRSIFKGVFLGHKLPLLVRLTSTTTNSKSNGSIPTQYTELSPLLVKQAEKYEAELKDLDKDLSCGIHFDVNKQKHYAKLSALTDTFIEYKEKLNELKSLQEMIVSDPSLRAEAEQEYAELVPQYETTSSRLVNKLLPPHPFADKPSLLELRPGVGGIEAMIFTQNLLDMYIGYANYRKWKYRIISKNENESGSGIIDAILSIEEAGSYDRLRFEAGVHRVQRIPSTETKGRTHTSTAAVVVLPQIGDESAKSIDAYERTFKPGEIRVDIMRASGKGGQ... | No | true_or_false | Biology | {
"level": "L3",
"source": "solubility",
"subtask": "solubility_prediction",
"task": "protein_function_prediction"
} | {
"label": [],
"text": []
} | sciknow_dff43fcb644ce7c9 | 5,984 | 20,260,428 | sciknoweval_v2_hard_autogradable_512_2026_04_28 | Biology_L3 | Biology | L3 | true_or_false | No | |
{
"default": "Given a true or false question, your task is to answer whether the question is true or not. Your answer should be \"Yes\" or \"No\". Please directly give the answer, DO NOT output any other characters."
} | Does the protein 'MNNPIPSNLKSEAKKAAKILREFTEITSRNGPDKIIPAHVIAKAKGLAILSVIKAGFLVTARGGSGIVVARLPDGKWSAPSAIGIAGLGGGFEIGIEVSDLVIILNYDRAVEAFAKGGNLTLGGNLTVAVGPLGRNLEGNVALRSSAAVFTYCKSRGLFAGVSLEGSCLIERKETNRKFYCQDIRAYDILFGDTPRPAQAEDLYEILDSFTEKYENEGQRINARKAAREQRKSSAKELPPKPLSRPQQSSAPVQLNSGSQSNRNEYKLYPGLSSYHERVGNLNQPIEVTALYSFEGQQPGDL... | Yes | true_or_false | Biology | {
"level": "L3",
"source": "solubility",
"subtask": "solubility_prediction",
"task": "protein_function_prediction"
} | {
"label": [],
"text": []
} | sciknow_61f03a0cea0a1a9a | 5,986 | 20,260,428 | sciknoweval_v2_hard_autogradable_512_2026_04_28 | Biology_L3 | Biology | L3 | true_or_false | Yes | |
{
"default": "Given a true or false question, your task is to answer whether the question is true or not. Your answer should be \"Yes\" or \"No\". Please directly give the answer, DO NOT output any other characters."
} | Does 'TPQYRTDEVELCCSPVELFHALGGRGALLEFEGTAIIAIPSGQVAHHIEELEVSGISVAPEAWAPPGWYGYIGYEANDATFGTAVHAPKPAEFPTTAMMYCTEVIAIRGDRAQITAPSSRWGRLRDAVVAA' have characteristics of a soluble protein? | No | true_or_false | Biology | {
"level": "L3",
"source": "solubility",
"subtask": "solubility_prediction",
"task": "protein_function_prediction"
} | {
"label": [],
"text": []
} | sciknow_be5fe4e176446077 | 5,995 | 20,260,428 | sciknoweval_v2_hard_autogradable_512_2026_04_28 | Biology_L3 | Biology | L3 | true_or_false | No | |
{
"default": "Given a true or false question, your task is to answer whether the question is true or not. Your answer should be \"Yes\" or \"No\". Please directly give the answer, DO NOT output any other characters."
} | Is this protein sequence 'MAEQMQISRRTILAGAALAGALAPVLATTSAWGQGAVRKATAAEIAALPRQKVELVDPPFVHAHSQVAEGGPKVVEFTMVIEEKKIVIDDAGTEVHAMAFNGTVPGPLMVVHQDDYLELTLINPETNTLMHNIDFHAATGALGGGGLTEINPGEKTILRFKATKPGVFVYHCAPPGMVPWHVVSGMNGAIMVLPREGLHDGKGKALTYDKIYYVGEQDFYVPRDENGKYKKYEAPGDAYEDTVKVMRTLTPTHVVFNGAVGALTGDKAMTAAVGEKVLIVHSQANRDTRPHLIG... | No | true_or_false | Biology | {
"level": "L3",
"source": "solubility",
"subtask": "solubility_prediction",
"task": "protein_function_prediction"
} | {
"label": [],
"text": []
} | sciknow_7f20ddc70ce8f452 | 5,996 | 20,260,428 | sciknoweval_v2_hard_autogradable_512_2026_04_28 | Biology_L3 | Biology | L3 | true_or_false | No | |
{
"default": "Given a true or false question, your task is to answer whether the question is true or not. Your answer should be \"Yes\" or \"No\". Please directly give the answer, DO NOT output any other characters."
} | Is water solubility expected for the protein 'MIQEAEEEDKKEKLDDILFSAATPGSWISSTSTCNEPLPVAPKEIPGENYIETLAALYKNSVERRRMFYCNGSLREMLGGTGLKMRPTRFDERYYKEKMRFELVLYVEMMNSMSVFRQMDLDTKETLVKGCAVSLAMLEKYYISVKYDGLRTQKLIAPDGSYTDLSDHGAQFDDEFTQITESVMDKETCLKLLYDPLRSCLNELGSALEHSRMTDTEFCALFAILLFNTAADNLSDASRNAVVMARNRVMKDWFEFYAKQGIDPHEAGLLVGNT... | No | true_or_false | Biology | {
"level": "L3",
"source": "solubility",
"subtask": "solubility_prediction",
"task": "protein_function_prediction"
} | {
"label": [],
"text": []
} | sciknow_961b26b1e054c95e | 6,006 | 20,260,428 | sciknoweval_v2_hard_autogradable_512_2026_04_28 | Biology_L3 | Biology | L3 | true_or_false | No | |
{
"default": "Given a true or false question, your task is to answer whether the question is true or not. Your answer should be \"Yes\" or \"No\". Please directly give the answer, DO NOT output any other characters."
} | Can this sequence 'MPSEAKYTWDQELNEINIQFPVTGDADSSAIKIRIVGKKICVKNQGEIVIDGELLHEVDVSSLWWVINGDVVDVNVTKKR' dissolve? | No | true_or_false | Biology | {
"level": "L3",
"source": "solubility",
"subtask": "solubility_prediction",
"task": "protein_function_prediction"
} | {
"label": [],
"text": []
} | sciknow_9735b822205818b1 | 6,032 | 20,260,428 | sciknoweval_v2_hard_autogradable_512_2026_04_28 | Biology_L3 | Biology | L3 | true_or_false | No | |
{
"default": "Given a true or false question, your task is to answer whether the question is true or not. Your answer should be \"Yes\" or \"No\". Please directly give the answer, DO NOT output any other characters."
} | Is this protein sequence 'MTLKTDLLPKINNEDYQRLILKHSAEFSGGEIRLLNEILEKFNFDVVQAQALAQAVMQQIRFDPNAYHIDSDDEDTTGICPHCINPPMPPLRDYLVWRETRG' soluble? | No | true_or_false | Biology | {
"level": "L3",
"source": "solubility",
"subtask": "solubility_prediction",
"task": "protein_function_prediction"
} | {
"label": [],
"text": []
} | sciknow_0701120359e4428f | 6,037 | 20,260,428 | sciknoweval_v2_hard_autogradable_512_2026_04_28 | Biology_L3 | Biology | L3 | true_or_false | No | |
{
"default": "Given a question and four options, please select the right answer. Your answer should be \"A\", \"B\", \"C\" or \"D\". Please directly give the answer without any explanation."
} | Question: When opening an ampoule containing lyophilized substances, the reduction in pressure may cause some material to eject. Where should this operation be conducted? | mcq-4-choices | Biology | {
"level": "L4",
"source": "real university test",
"subtask": "laboratory_safety_test_mcq",
"task": "laboratory_safety_test"
} | C | {
"label": [
"A",
"B",
"C",
"D"
],
"text": [
"In a sterile room",
"Inside a laminar flow hood",
"Inside a biological safety cabinet",
"On the laboratory bench"
]
} | sciknow_2e272fbca7f662b6 | 6,580 | 20,260,428 | sciknoweval_v2_hard_autogradable_512_2026_04_28 | Biology_L4 | Biology | L4 | mcq-4-choices | C | |
{
"default": "Given a question and four options, please select the right answer. Your answer should be \"A\", \"B\", \"C\" or \"D\". Please directly give the answer without any explanation."
} | Question: Which of the following statements about the precautions for using an autoclave is incorrect? | mcq-4-choices | Biology | {
"level": "L4",
"source": "real university test",
"subtask": "laboratory_safety_test_mcq",
"task": "laboratory_safety_test"
} | C | {
"label": [
"A",
"B",
"C",
"D"
],
"text": [
"Take protective measures to prevent burns and wait for the temperature to drop before opening the lid.",
"Regularly inspect the drainage bucket and drainage pipe.",
"Fill the autoclave with items as much as possible in one cycle.",
"Do ... | sciknow_dd66e59e995d4821 | 6,582 | 20,260,428 | sciknoweval_v2_hard_autogradable_512_2026_04_28 | Biology_L4 | Biology | L4 | mcq-4-choices | C | |
{
"default": "Given a question and four options, please select the right answer. Your answer should be \"A\", \"B\", \"C\" or \"D\". Please directly give the answer without any explanation."
} | Which department in a school is responsible for supplying qualified experimental animals or providing qualified animal experiment facilities? | mcq-4-choices | Biology | {
"level": "L4",
"source": "real university test",
"subtask": "laboratory_safety_test_mcq",
"task": "laboratory_safety_test"
} | B | {
"label": [
"A",
"B",
"C",
"D"
],
"text": [
"Equipment Supply Department",
"Laboratory Animal Center",
"Logistics Department",
"Material Supply Center"
]
} | sciknow_3379b442a35ad248 | 6,607 | 20,260,428 | sciknoweval_v2_hard_autogradable_512_2026_04_28 | Biology_L4 | Biology | L4 | mcq-4-choices | B | |
{
"default": "Given a question and four options, please select the right answer. Your answer should be \"A\", \"B\", \"C\" or \"D\". Please directly give the answer without any explanation."
} | Please determine whether the following proteins are toxic and select one that is toxic. | mcq-4-choices | Biology | {
"level": "L4",
"source": "UniProtKB",
"subtask": "proteotoxicity_prediction_mcq",
"task": "proteotoxicity_prediction"
} | D | {
"label": [
"A",
"B",
"C",
"D"
],
"text": [
"entry: Q45VN2 protein_name: Alpha-defensin 20 (Cryptdin-4) (Defensin-related cryptdin-20) sequence: MKTLVLLSALVLLAFQVQADPIQNTDEETNTEEQPGEEDQAVSVSFGDPEGSALHEKSSRDLICYCRKGGCNRGEQVYGTCSGRLLFCCRRRHRH",
"entry: Q2G0B4 protein_name: Undecaprenyl-diph... | sciknow_eb9cafc36495588f | 6,627 | 20,260,428 | sciknoweval_v2_hard_autogradable_512_2026_04_28 | Biology_L4 | Biology | L4 | mcq-4-choices | D | |
{
"default": "Given a question and four options, please select the right answer. Your answer should be \"A\", \"B\", \"C\" or \"D\". Please directly give the answer without any explanation."
} | Please determine whether the following proteins are toxic and select one that is toxic. | mcq-4-choices | Biology | {
"level": "L4",
"source": "UniProtKB",
"subtask": "proteotoxicity_prediction_mcq",
"task": "proteotoxicity_prediction"
} | A | {
"label": [
"A",
"B",
"C",
"D"
],
"text": [
"entry: P59898 protein_name: Beta-toxin Cll2 (Cll 2) (Cll2) sequence: KEGYLVNHSTGCKYECFKLGDNDYCLRECKQQYGKGAGGYCYAFGCWCNHLYEQAVVWPLPKKTCN",
"entry: P06866 protein_name: Haptoglobin (Liver regeneration-related protein LRRG173) [Cleaved into: Hapto... | sciknow_f172a160ce6c3c56 | 6,628 | 20,260,428 | sciknoweval_v2_hard_autogradable_512_2026_04_28 | Biology_L4 | Biology | L4 | mcq-4-choices | A | |
{
"default": "Given a question and four options, please select the right answer. Your answer should be \"A\", \"B\", \"C\" or \"D\". Please directly give the answer without any explanation."
} | Please determine whether the following proteins are toxic and select one that is non-toxic. | mcq-4-choices | Biology | {
"level": "L4",
"source": "UniProtKB",
"subtask": "proteotoxicity_prediction_mcq",
"task": "proteotoxicity_prediction"
} | D | {
"label": [
"A",
"B",
"C",
"D"
],
"text": [
"entry: B1P1H5 protein_name: U25-theraphotoxin-Cg1b (U25-TRTX-Cg1b) (Jingzhaotoxin-55) (JZTX-55) sequence: MRFHTLLFLSFLLLVSCALICTAQHPGLEKSGMFHENVGKGQHIEEKRSCIERMQTCGVEAGLPCCSGAPCICPYIGDCICIQ",
"entry: P98185 protein_name: Ribosome-inactivating p... | sciknow_13af959ffa459e41 | 6,629 | 20,260,428 | sciknoweval_v2_hard_autogradable_512_2026_04_28 | Biology_L4 | Biology | L4 | mcq-4-choices | D | |
{
"default": "Given a question and four options, please select the right answer. Your answer should be \"A\", \"B\", \"C\" or \"D\". Please directly give the answer without any explanation."
} | Please determine whether the following proteins are toxic and select one that is non-toxic. | mcq-4-choices | Biology | {
"level": "L4",
"source": "UniProtKB",
"subtask": "proteotoxicity_prediction_mcq",
"task": "proteotoxicity_prediction"
} | A | {
"label": [
"A",
"B",
"C",
"D"
],
"text": [
"entry: Q6GI27 protein_name: Teichoic acid D-alanine hydrolase (EC 3.1.1.103) (Teichoic acid D-alanine esterase) sequence: MKFNKEKLVIHACVLLFIIISIGLVFHRLQTKTNSIEPIHKETKLSDNAKYLVDRNKGKGEPSKLKEVYNSKDPKYKKIDRYLQNSLFNGSVAVYENGKLKMSKGYGYQDFEKGIKNTPNTMFLIG... | sciknow_1fe303e87786f6d4 | 6,646 | 20,260,428 | sciknoweval_v2_hard_autogradable_512_2026_04_28 | Biology_L4 | Biology | L4 | mcq-4-choices | A | |
{
"default": "Given a question and four options, please select the right answer. Your answer should be \"A\", \"B\", \"C\" or \"D\". Please directly give the answer without any explanation."
} | Please determine whether the following proteins are toxic and select one that is non-toxic. | mcq-4-choices | Biology | {
"level": "L4",
"source": "UniProtKB",
"subtask": "proteotoxicity_prediction_mcq",
"task": "proteotoxicity_prediction"
} | C | {
"label": [
"A",
"B",
"C",
"D"
],
"text": [
"entry: B2ZBC0 protein_name: Kunitz-type U15-theraphotoxin-Hs1c (U15-TRTX-Hs1c) (Kunitz-type serine protease inhibitor huwentoxin-11g9) (HW11g9) sequence: MGTARFLSAVLLLSVLLMVTFPALLSAEYHDGRVDICSLPPDSGDCLRFFEMWYFDGTTCTKFVYGGYGGNDNRFPTEKACMKRCAKA",
... | sciknow_ef6a5418cd1a6cb9 | 6,654 | 20,260,428 | sciknoweval_v2_hard_autogradable_512_2026_04_28 | Biology_L4 | Biology | L4 | mcq-4-choices | C | |
{
"default": "Given a question and four options, please select the right answer. Your answer should be \"A\", \"B\", \"C\" or \"D\". Please directly give the answer without any explanation."
} | Please determine whether the following proteins are toxic and select one that is toxic. | mcq-4-choices | Biology | {
"level": "L4",
"source": "UniProtKB",
"subtask": "proteotoxicity_prediction_mcq",
"task": "proteotoxicity_prediction"
} | C | {
"label": [
"A",
"B",
"C",
"D"
],
"text": [
"entry: Q6GKS6 protein_name: Sensor protein kinase WalK (EC 2.7.13.3) sequence: MKWLKQLQSLHTKLVIVYVLLIIIGMQIIGLYFTNNLEKELLDNFKKNITQYAKQLEISIEKVYDEKGSVNAQKDIQNLLSEYANRQEIGEIRFIDKDQIIIATTKQSNRSLINQKANDSSVQKALSLGQSNDHLILKDYGGGKDRVWVYNIPVKVDKKVIGNIYIESK... | sciknow_c3a8979a6c3e1d06 | 6,677 | 20,260,428 | sciknoweval_v2_hard_autogradable_512_2026_04_28 | Biology_L4 | Biology | L4 | mcq-4-choices | C | |
{
"default": "Given a question and four options, please select the right answer. Your answer should be \"A\", \"B\", \"C\" or \"D\". Please directly give the answer without any explanation."
} | Please determine whether the following proteins are toxic and select one that is toxic. | mcq-4-choices | Biology | {
"level": "L4",
"source": "UniProtKB",
"subtask": "proteotoxicity_prediction_mcq",
"task": "proteotoxicity_prediction"
} | D | {
"label": [
"A",
"B",
"C",
"D"
],
"text": [
"entry: P69135 protein_name: Tachyplesin-1 (Tachyplesin I) sequence: KWCFRVCYRGICYRRCR",
"entry: Q6QLR2 protein_name: Gallinacin-7 (Gal 7) (Beta-defensin 7) (Gallinacin-5) (Gal-5) sequence: MRILYLLLSVLFVVLQGVAGQPFIPRPIDTCRLRNGICFPGICRRPYYWIGTCNN... | sciknow_eb9cafc36495588f | 6,678 | 20,260,428 | sciknoweval_v2_hard_autogradable_512_2026_04_28 | Biology_L4 | Biology | L4 | mcq-4-choices | D | |
{
"default": "Given a question and four options, please select the right answer. Your answer should be \"A\", \"B\", \"C\" or \"D\". Please directly give the answer without any explanation."
} | Please determine whether the following proteins are toxic and select one that is toxic. | mcq-4-choices | Biology | {
"level": "L4",
"source": "UniProtKB",
"subtask": "proteotoxicity_prediction_mcq",
"task": "proteotoxicity_prediction"
} | A | {
"label": [
"A",
"B",
"C",
"D"
],
"text": [
"entry: D2Y2A5 protein_name: U7-theraphotoxin-Hhn1d (U7-TRTX-Hhn1d) (Hainantoxin-XIII-5) (HNTX-XIII-5) sequence: MKTAIFTVVLALAVFAVLSFGWEANEKALSEEFTELIHEKEAASETEARECRYFWGECHDHMPCCDWLVCRCKWPITYNICVWNRTFPEK",
"entry: Q3KD12 protein_name: Undecapren... | sciknow_f172a160ce6c3c56 | 6,697 | 20,260,428 | sciknoweval_v2_hard_autogradable_512_2026_04_28 | Biology_L4 | Biology | L4 | mcq-4-choices | A | |
{
"default": "Given a question and four options, please select the right answer. Your answer should be \"A\", \"B\", \"C\" or \"D\". Please directly give the answer without any explanation."
} | Please determine whether the following proteins are toxic and select one that is toxic. | mcq-4-choices | Biology | {
"level": "L4",
"source": "UniProtKB",
"subtask": "proteotoxicity_prediction_mcq",
"task": "proteotoxicity_prediction"
} | A | {
"label": [
"A",
"B",
"C",
"D"
],
"text": [
"entry: P49268 protein_name: Mu-cyrtautoxin-As1a (Mu-CUTX-As1a) (Aptotoxin III) (Aps III) (Aptotoxin-3) (Aps-3) (Paralytic peptide III) (PP III) sequence: CNSKGTPCTNADECCGGKCAYNVWNCIGGGCSKTCGY",
"entry: Q5BA81 protein_name: Acyl-CoA ligase easD ... | sciknow_f172a160ce6c3c56 | 6,708 | 20,260,428 | sciknoweval_v2_hard_autogradable_512_2026_04_28 | Biology_L4 | Biology | L4 | mcq-4-choices | A | |
{
"default": "Given a question and four options, please select the right answer. Your answer should be \"A\", \"B\", \"C\" or \"D\". Please directly give the answer without any explanation."
} | Please determine whether the following proteins are toxic and select one that is toxic. | mcq-4-choices | Biology | {
"level": "L4",
"source": "UniProtKB",
"subtask": "proteotoxicity_prediction_mcq",
"task": "proteotoxicity_prediction"
} | B | {
"label": [
"A",
"B",
"C",
"D"
],
"text": [
"entry: O96447 protein_name: Antimicrobial peptide lumbricin-1 sequence: MSLCISDYLYLTLTFSKYERQKDKRPYSERKNQYTGPQFLYPPERIPPQKVIKWNEEGLPIYEIPGEGGHAEPAAA",
"entry: P58762 protein_name: Toxin CqTX-A (CQT-A) (Toxin A) sequence: MANMLYFSLLALLFMTGIASEGT... | sciknow_e67751d6eca6654b | 6,715 | 20,260,428 | sciknoweval_v2_hard_autogradable_512_2026_04_28 | Biology_L4 | Biology | L4 | mcq-4-choices | B | |
{
"default": "Given a question and four options, please select the right answer. Your answer should be \"A\", \"B\", \"C\" or \"D\". Please directly give the answer without any explanation."
} | Please determine whether the following proteins are toxic and select one that is non-toxic. | mcq-4-choices | Biology | {
"level": "L4",
"source": "UniProtKB",
"subtask": "proteotoxicity_prediction_mcq",
"task": "proteotoxicity_prediction"
} | B | {
"label": [
"A",
"B",
"C",
"D"
],
"text": [
"entry: P30785 protein_name: Delta-stichotoxin-Hcr1d (Delta-SHTX-Hcr1d) (Neurotoxins V) (RTX-V) (Rm5) sequence: GNCKCDDEGPNVRTAPLTGYVDLGYCNEGWEKCASYYSPIAECCRKK",
"entry: A1CFM1 protein_name: Isoepoxydon dehydrogenase patN (IDH) (EC 1.1.1.-) (Pat... | sciknow_263bc05a6c3c0e62 | 6,727 | 20,260,428 | sciknoweval_v2_hard_autogradable_512_2026_04_28 | Biology_L4 | Biology | L4 | mcq-4-choices | B | |
{
"default": "Given a question and four options, please select the right answer. Your answer should be \"A\", \"B\", \"C\" or \"D\". Please directly give the answer without any explanation."
} | Please determine whether the following proteins are toxic and select one that is non-toxic. | mcq-4-choices | Biology | {
"level": "L4",
"source": "UniProtKB",
"subtask": "proteotoxicity_prediction_mcq",
"task": "proteotoxicity_prediction"
} | D | {
"label": [
"A",
"B",
"C",
"D"
],
"text": [
"entry: H1ZZI2 protein_name: Sodium channel toxin To13 (T NaTx8.1) sequence: MKTLFLIITSFILLEVEGIKNGYPRDSKGCTFECGQDAKHGDDYCDKMCKTTLKGEGGDCDFEYAECWCDNIPDTVVTWKNKEPKCKQI",
"entry: P0DMZ3 protein_name: U-actitoxin-Avd8a (U-AITX-Avd8a) (Avtx-1) seque... | sciknow_13af959ffa459e41 | 6,738 | 20,260,428 | sciknoweval_v2_hard_autogradable_512_2026_04_28 | Biology_L4 | Biology | L4 | mcq-4-choices | D | |
{
"default": "Given a question and four options, please select the right answer. Your answer should be \"A\", \"B\", \"C\" or \"D\". Please directly give the answer without any explanation."
} | Please determine whether the following proteins are toxic and select one that is toxic. | mcq-4-choices | Biology | {
"level": "L4",
"source": "UniProtKB",
"subtask": "proteotoxicity_prediction_mcq",
"task": "proteotoxicity_prediction"
} | A | {
"label": [
"A",
"B",
"C",
"D"
],
"text": [
"entry: P0C942 protein_name: Basic phospholipase A2 LmTX-I (svPLA2) (EC 3.1.1.4) (Phosphatidylcholine 2-acylhydrolase) sequence: HLLKFNKMIKFETRKNAIPFYAFYGCYCGWGGRXXXXXXXXXCCFVHDCCYGKXXXXXXXWDLYRYSLKSGYLTCGKGTWCEEQICECDRVAAECLRRSLSTYKYGYMFYPDSRCRGPSE... | sciknow_f172a160ce6c3c56 | 6,739 | 20,260,428 | sciknoweval_v2_hard_autogradable_512_2026_04_28 | Biology_L4 | Biology | L4 | mcq-4-choices | A | |
{
"default": "Given a question and four options, please select the right answer. Your answer should be \"A\", \"B\", \"C\" or \"D\". Please directly give the answer without any explanation."
} | Please determine whether the following proteins are toxic and select one that is non-toxic. | mcq-4-choices | Biology | {
"level": "L4",
"source": "UniProtKB",
"subtask": "proteotoxicity_prediction_mcq",
"task": "proteotoxicity_prediction"
} | D | {
"label": [
"A",
"B",
"C",
"D"
],
"text": [
"entry: Q3HXX5 protein_name: Venom nerve growth factor 4 (v-NGF-4) (vNGF-4) sequence: MSMLCYTLIIAFLIGIWAAPKSEDNVPLGSPATSDLSDTSCAQTHEGLKTSRNTDQRHPAPKKAEDQELGSAANIIVDPKLFQKRRFQSSRVLFSTQPPPLSRGEQSVEFLDNEDTLNRNIRAKRENHPVHNQGEHSVCDSVSDWVIKTTATDIRGNVVTVME... | sciknow_13af959ffa459e41 | 6,740 | 20,260,428 | sciknoweval_v2_hard_autogradable_512_2026_04_28 | Biology_L4 | Biology | L4 | mcq-4-choices | D | |
{
"default": "Given a question and four options, please select the right answer. Your answer should be \"A\", \"B\", \"C\" or \"D\". Please directly give the answer without any explanation."
} | Please determine whether the following proteins are toxic and select one that is non-toxic. | mcq-4-choices | Biology | {
"level": "L4",
"source": "UniProtKB",
"subtask": "proteotoxicity_prediction_mcq",
"task": "proteotoxicity_prediction"
} | D | {
"label": [
"A",
"B",
"C",
"D"
],
"text": [
"entry: I6S7H3 protein_name: Kappa-scoloptoxin(07)-Ssm2f (Kappa-SLPTX(07)-Ssm2f) (Kappa-scoloptoxin-Ssm2f) (Kappa-SLPTX-Ssm2f) sequence: MLVFYAILFVTVFSNTVMGATIDKPIPKPIFREAIEEMEVNKRAKNPYCKEEKCPVGKHCPKKPIVCRIGPCCV",
"entry: W4VSB7 protein_name: To... | sciknow_13af959ffa459e41 | 6,747 | 20,260,428 | sciknoweval_v2_hard_autogradable_512_2026_04_28 | Biology_L4 | Biology | L4 | mcq-4-choices | D | |
{
"default": "Given a question and four options, please select the right answer. Your answer should be \"A\", \"B\", \"C\" or \"D\". Please directly give the answer without any explanation."
} | Please determine whether the following proteins are toxic and select one that is toxic. | mcq-4-choices | Biology | {
"level": "L4",
"source": "UniProtKB",
"subtask": "proteotoxicity_prediction_mcq",
"task": "proteotoxicity_prediction"
} | C | {
"label": [
"A",
"B",
"C",
"D"
],
"text": [
"entry: Q814V1 protein_name: UPF0340 protein BC_5317 sequence: MTEIVKVREQLQMSLSDFQEQASLQSGQIFVVGCSTSEVLGERIGTSGTMEVAEAIFSELKQFQEQTGIELAFQCCEHLNRALVVEREVAIKYQFEIVTVTPVRSAGGALGTYAYHNLKDPVVVEFIKADAGMDIGDTFIGMHLKHVAVPVRTNVKEIGSAHVTMAKTRGKLIGGARAVYAAVEET... | sciknow_c3a8979a6c3e1d06 | 6,765 | 20,260,428 | sciknoweval_v2_hard_autogradable_512_2026_04_28 | Biology_L4 | Biology | L4 | mcq-4-choices | C | |
{
"default": "Given a question and four options, please select the right answer. Your answer should be \"A\", \"B\", \"C\" or \"D\". Please directly give the answer without any explanation."
} | Please determine whether the following proteins are toxic and select one that is non-toxic. | mcq-4-choices | Biology | {
"level": "L4",
"source": "UniProtKB",
"subtask": "proteotoxicity_prediction_mcq",
"task": "proteotoxicity_prediction"
} | A | {
"label": [
"A",
"B",
"C",
"D"
],
"text": [
"entry: C7G3K3 protein_name: Peptide LaIT2 sequence: MAKHLIVMFLVIMVISSLVDCAKKPFVQRVKNAASKAYNKLKGLAMQSQYGCPIISNMCEDHCRRKKMEGQCDLLDCVCS",
"entry: C0HKY3 protein_name: Conotoxin ar5b sequence: RCCGYKFCYIC",
"entry: C0HLA4 protein_name: Snaclec ... | sciknow_1fe303e87786f6d4 | 6,778 | 20,260,428 | sciknoweval_v2_hard_autogradable_512_2026_04_28 | Biology_L4 | Biology | L4 | mcq-4-choices | A |
End of preview. Expand in Data Studio
SciKnowEval v2 Hard Autogradable 512 - 2026-04-28
A 512-example sanity subset sampled from hicai-zju/SciKnowEval (v2, test) for Plan-CRL scientific reasoning evals.
Selection seed: 20260428.
Filtering and balancing:
- excludes
L1 - keeps
L2,L3,L4 - keeps autogradable types:
mcq-4-choices,mcq-2-choices,true_or_false,filling - requires
answerKeyoranswer - balances domains at 128 examples each: Biology, Chemistry, Material, Physics
- per domain: 32 L2, 48 L3, 48 L4
Useful fields for manual inspection:
questionchoicestargetselection_domainselection_levelselection_typedetails.taskdetails.subtask
Extra files:
metadata/selection_summary.jsonmetadata/selection_manifest.csv
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