prompt dict | question stringlengths 40 2.45k | answer stringclasses 9
values | type stringclasses 4
values | domain stringclasses 4
values | details dict | answerKey stringclasses 5
values | choices dict | sample_id stringlengths 24 24 | dataset_index int64 4.02k 28.1k | selection_seed int64 20.3M 20.3M | selection_name stringclasses 1
value | selection_group stringclasses 12
values | selection_domain stringclasses 4
values | selection_level stringclasses 3
values | selection_type stringclasses 4
values | target stringclasses 12
values |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
{
"default": "Given a question and four options, please select the right answer. Your answer should be \"A\", \"B\", \"C\" or \"D\". Please directly give the answer without any explanation."
} | Please determine whether the following proteins are toxic and select one that is toxic. | mcq-4-choices | Biology | {
"level": "L4",
"source": "UniProtKB",
"subtask": "proteotoxicity_prediction_mcq",
"task": "proteotoxicity_prediction"
} | B | {
"label": [
"A",
"B",
"C",
"D"
],
"text": [
"entry: Q5PPJ2 protein_name: Serine/Arginine-related protein 53 (SRrp53) (Arginine/serine-rich coiled-coil protein 1) sequence: MGRRSSDTEEESRSKRKKKHRRRSSSSSSSDSRTYSRKKGGRRPRSESRSWSRDRQPRSHSYERRRRRRSSSSSSYGSRRKRSRSRSRGRGKSYRVQRSRSKSRTRRSRSRPRPRSHSRSS... | sciknow_e67751d6eca6654b | 6,800 | 20,260,428 | sciknoweval_v2_hard_autogradable_512_2026_04_28 | Biology_L4 | Biology | L4 | mcq-4-choices | B | |
{
"default": "Given a question and four options, please select the right answer. Your answer should be \"A\", \"B\", \"C\" or \"D\". Please directly give the answer without any explanation."
} | Please determine whether the following proteins are toxic and select one that is toxic. | mcq-4-choices | Biology | {
"level": "L4",
"source": "UniProtKB",
"subtask": "proteotoxicity_prediction_mcq",
"task": "proteotoxicity_prediction"
} | D | {
"label": [
"A",
"B",
"C",
"D"
],
"text": [
"entry: B5L5P0 protein_name: Carwaprin-b sequence: MSSGGLLLLLGLLTLWAELTPVSSQDRPKKPGLCPPRPQKPPCVRECKNDWRCPGEQKCCRYGCIYECRDPIFVK",
"entry: O93452 protein_name: Dermaseptin-DA2 (DRS-DA2) (Dermaseptin PD-2-2) sequence: MALVKKSLFLVLFLGLVSLSICEEKRENED... | sciknow_eb9cafc36495588f | 6,806 | 20,260,428 | sciknoweval_v2_hard_autogradable_512_2026_04_28 | Biology_L4 | Biology | L4 | mcq-4-choices | D | |
{
"default": "Given a question and four options, please select the right answer. Your answer should be \"A\", \"B\", \"C\" or \"D\". Please directly give the answer without any explanation."
} | Please determine whether the following proteins are toxic and select one that is non-toxic. | mcq-4-choices | Biology | {
"level": "L4",
"source": "UniProtKB",
"subtask": "proteotoxicity_prediction_mcq",
"task": "proteotoxicity_prediction"
} | B | {
"label": [
"A",
"B",
"C",
"D"
],
"text": [
"entry: B6DCV4 protein_name: U6-lycotoxin-Ls1d (Toxin-like structure LSTX-F4) sequence: MKLLFFTALVLVVISLIEVEAENERACIPLEKECTKTPGNCCSGLKCDCYRRFEQGVAKGIQCWCIEKDVTYKGV",
"entry: P84759 protein_name: Jellein-3 (Jelleine-III) sequence: EPFKISIHL",
... | sciknow_263bc05a6c3c0e62 | 6,809 | 20,260,428 | sciknoweval_v2_hard_autogradable_512_2026_04_28 | Biology_L4 | Biology | L4 | mcq-4-choices | B | |
{
"default": "Given a question and four options, please select the right answer. Your answer should be \"A\", \"B\", \"C\" or \"D\". Please directly give the answer without any explanation."
} | Please determine whether the following proteins are toxic and select one that is non-toxic. | mcq-4-choices | Biology | {
"level": "L4",
"source": "UniProtKB",
"subtask": "proteotoxicity_prediction_mcq",
"task": "proteotoxicity_prediction"
} | C | {
"label": [
"A",
"B",
"C",
"D"
],
"text": [
"entry: P81508 protein_name: Snaclec CHH-B subunit alpha sequence: DLECPSGWSSYDRYCYKPFKQEMTWADAERFCSEQAKGRHLLSVETALEASFVDNVLYANKEYLTRYIWIGLRVQNKGQPCSSIYSENLVDPFDCFMVSRDTRLREWFKVDCEQQHSFICKFTRPRR",
"entry: Q68PH0 protein_name: Neurotoxin Cex5 seq... | sciknow_ef6a5418cd1a6cb9 | 6,811 | 20,260,428 | sciknoweval_v2_hard_autogradable_512_2026_04_28 | Biology_L4 | Biology | L4 | mcq-4-choices | C | |
{
"default": "Given a question and four options, please select the right answer. Your answer should be \"A\", \"B\", \"C\" or \"D\". Please directly give the answer without any explanation."
} | Please determine whether the following proteins are toxic and select one that is toxic. | mcq-4-choices | Biology | {
"level": "L4",
"source": "UniProtKB",
"subtask": "proteotoxicity_prediction_mcq",
"task": "proteotoxicity_prediction"
} | B | {
"label": [
"A",
"B",
"C",
"D"
],
"text": [
"entry: Q1JS92 protein_name: Ranatuerin-2Va (ranat2Va) (2VEa) sequence: MFTLKKSFLLLFFLGTITLSLCEQERGADEDDGVEMTEEEVKRGLLDTIKNTAKNLAVGLLDKIKCKMTGC",
"entry: P79799 protein_name: Natriuretic peptide Mc-NP (Micrurus natriuretic peptide) (MNP) sequenc... | sciknow_e67751d6eca6654b | 6,849 | 20,260,428 | sciknoweval_v2_hard_autogradable_512_2026_04_28 | Biology_L4 | Biology | L4 | mcq-4-choices | B | |
{
"default": "Given a question and four options, please select the right answer. Your answer should be \"A\", \"B\", \"C\" or \"D\". Please directly give the answer without any explanation."
} | Please determine whether the following proteins are toxic and select one that is toxic. | mcq-4-choices | Biology | {
"level": "L4",
"source": "UniProtKB",
"subtask": "proteotoxicity_prediction_mcq",
"task": "proteotoxicity_prediction"
} | D | {
"label": [
"A",
"B",
"C",
"D"
],
"text": [
"entry: P39640 protein_name: Dihydroanticapsin 7-dehydrogenase (EC 1.1.1.385) (Bacilysin biosynthesis oxidoreductase BacC) sequence: MNLTDKTVLITGGASGIGYAAVQAFLGQQANVVVADIDEAQGEAMVRKENNDRLHFVQTDITDEAACQHAVESAVHTFGGLDVLINNAGIEIVAPIHEMELSDWNKVLQVNLTGMF... | sciknow_eb9cafc36495588f | 6,872 | 20,260,428 | sciknoweval_v2_hard_autogradable_512_2026_04_28 | Biology_L4 | Biology | L4 | mcq-4-choices | D | |
{
"default": "Given a question and four options, please select the right answer. Your answer should be \"A\", \"B\", \"C\" or \"D\". Please directly give the answer without any explanation."
} | Please determine whether the following proteins are toxic and select one that is non-toxic. | mcq-4-choices | Biology | {
"level": "L4",
"source": "UniProtKB",
"subtask": "proteotoxicity_prediction_mcq",
"task": "proteotoxicity_prediction"
} | C | {
"label": [
"A",
"B",
"C",
"D"
],
"text": [
"entry: P85162 protein_name: Bradykinin-potentiating peptide 12c (BPP-12c) [Cleaved into: Bradykinin-potentiating peptide 9a (BPP-9a) (BPP-a) (Bradykinin-potentiating peptide V-6-I) (BPPV-6-I) (Teprotide); Bradykinin-potentiating peptide 9a-F (BPP-9... | sciknow_ef6a5418cd1a6cb9 | 6,889 | 20,260,428 | sciknoweval_v2_hard_autogradable_512_2026_04_28 | Biology_L4 | Biology | L4 | mcq-4-choices | C | |
{
"default": "Given a question and four options, please select the right answer. Your answer should be \"A\", \"B\", \"C\" or \"D\". Please directly give the answer without any explanation."
} | Please determine whether the following proteins are toxic and select one that is toxic. | mcq-4-choices | Biology | {
"level": "L4",
"source": "UniProtKB",
"subtask": "proteotoxicity_prediction_mcq",
"task": "proteotoxicity_prediction"
} | B | {
"label": [
"A",
"B",
"C",
"D"
],
"text": [
"entry: Q9S745 protein_name: Lipase-like PAD4 (EC 2.3.1.-) (Protein ENHANCED DISEASE SUSCEPTIBILITY 9) (Protein PHYTOALEXIN DEFICIENT 4) (AtPAD4) sequence: MDDCRFETSELQASVMISTPLFTDSWSSCNTANCNGSIKIHDIAGITYVAIPAVSMIQLGNLVGLPVTGDVLFPGLSSDEPLPMVDAAILKLF... | sciknow_e67751d6eca6654b | 6,892 | 20,260,428 | sciknoweval_v2_hard_autogradable_512_2026_04_28 | Biology_L4 | Biology | L4 | mcq-4-choices | B | |
{
"default": "You are a professional laboratory safety expert, here is a true-false question regarding lab safety knowledge. Your answer should be \"Yes\" or \"No\". Please directly give the answer, DO NOT output any other characters."
} | When storing ampoules in a liquid nitrogen tank, they should be kept in the vapor phase of the nitrogen. | Yes | true_or_false | Biology | {
"level": "L4",
"source": "real university test",
"subtask": "laboratory_safety_test_judgement",
"task": "laboratory_safety_test"
} | {
"label": [],
"text": []
} | sciknow_d12473b9da59aea1 | 6,528 | 20,260,428 | sciknoweval_v2_hard_autogradable_512_2026_04_28 | Biology_L4 | Biology | L4 | true_or_false | Yes | |
{
"default": "You are a professional laboratory safety expert, here is a true-false question regarding lab safety knowledge. Your answer should be \"Yes\" or \"No\". Please directly give the answer, DO NOT output any other characters."
} | When handling toads during animal experiments, students should ensure that the toad's head faces outward and avoid squeezing the parotid glands behind the ears to prevent secretion from getting into the experimenter's eyes. In case of contact, the eyes should be immediately flushed with saline solution. | Yes | true_or_false | Biology | {
"level": "L4",
"source": "real university test",
"subtask": "laboratory_safety_test_judgement",
"task": "laboratory_safety_test"
} | {
"label": [],
"text": []
} | sciknow_9972a46264b47bcf | 6,533 | 20,260,428 | sciknoweval_v2_hard_autogradable_512_2026_04_28 | Biology_L4 | Biology | L4 | true_or_false | Yes | |
{
"default": "You are a professional laboratory safety expert, here is a true-false question regarding lab safety knowledge. Your answer should be \"Yes\" or \"No\". Please directly give the answer, DO NOT output any other characters."
} | After using the sterile room, items must be cleaned, and the UV light should be turned on for disinfection and sterilization for approximately 30 minutes. | No | true_or_false | Biology | {
"level": "L4",
"source": "real university test",
"subtask": "laboratory_safety_test_judgement",
"task": "laboratory_safety_test"
} | {
"label": [],
"text": []
} | sciknow_caeab5372ff863c4 | 6,545 | 20,260,428 | sciknoweval_v2_hard_autogradable_512_2026_04_28 | Biology_L4 | Biology | L4 | true_or_false | No | |
{
"default": "You are a professional laboratory safety expert, here is a true-false question regarding lab safety knowledge. Your answer should be \"Yes\" or \"No\". Please directly give the answer, DO NOT output any other characters."
} | When filtering infectious substances using glass filters, first soak them in a 2% phenol solution for at least 2 hours, and then wash them. | Yes | true_or_false | Biology | {
"level": "L4",
"source": "real university test",
"subtask": "laboratory_safety_test_judgement",
"task": "laboratory_safety_test"
} | {
"label": [],
"text": []
} | sciknow_66d4c5c85322cd7c | 6,547 | 20,260,428 | sciknoweval_v2_hard_autogradable_512_2026_04_28 | Biology_L4 | Biology | L4 | true_or_false | Yes | |
{
"default": "You are a professional laboratory safety expert, here is a true-false question regarding lab safety knowledge. Your answer should be \"Yes\" or \"No\". Please directly give the answer, DO NOT output any other characters."
} | Biological factors refer to all microorganisms and bioactive substances. | Yes | true_or_false | Biology | {
"level": "L4",
"source": "real university test",
"subtask": "laboratory_safety_test_judgement",
"task": "laboratory_safety_test"
} | {
"label": [],
"text": []
} | sciknow_c8cd22daf72039e1 | 6,567 | 20,260,428 | sciknoweval_v2_hard_autogradable_512_2026_04_28 | Biology_L4 | Biology | L4 | true_or_false | Yes | |
{
"default": "You are a professional laboratory safety expert, here is a true-false question regarding lab safety knowledge. Your answer should be \"Yes\" or \"No\". Please directly give the answer, DO NOT output any other characters."
} | Regarding ultraviolet disinfection, visible light can reactivate photolyase in organisms, causing the dimer formed to disassemble and restore, thus fluorescent lights and ultraviolet lights should not be used simultaneously. | Yes | true_or_false | Biology | {
"level": "L4",
"source": "real university test",
"subtask": "laboratory_safety_test_judgement",
"task": "laboratory_safety_test"
} | {
"label": [],
"text": []
} | sciknow_fc1858da92d73581 | 6,572 | 20,260,428 | sciknoweval_v2_hard_autogradable_512_2026_04_28 | Biology_L4 | Biology | L4 | true_or_false | Yes | |
{
"default": "Given a true or false question, your task is to answer whether the question is true or not. Your answer should be \"Yes\" or \"No\". Please directly give the answer, DO NOT output any other characters."
} | Please determine whether the following protein is toxic.
entry: Q8ZDX8 protein_name: Bifunctional polymyxin resistance protein ArnA [Includes: UDP-4-amino-4-deoxy-L-arabinose formyltransferase (EC 2.1.2.13) (ArnAFT) (UDP-L-Ara4N formyltransferase); UDP-glucuronic acid oxidase, UDP-4-keto-hexauronic acid decarboxylating... | No | true_or_false | Biology | {
"level": "L4",
"source": "UniProtKB",
"subtask": "proteotoxicity_prediction_judgement",
"task": "proteotoxicity_prediction"
} | {
"label": [],
"text": []
} | sciknow_b91fdd49bbfb89f0 | 6,618 | 20,260,428 | sciknoweval_v2_hard_autogradable_512_2026_04_28 | Biology_L4 | Biology | L4 | true_or_false | No | |
{
"default": "Given a true or false question, your task is to answer whether the question is true or not. Your answer should be \"Yes\" or \"No\". Please directly give the answer, DO NOT output any other characters."
} | Please determine whether the following protein is toxic.
entry: P15229 protein_name: Chlorotoxin-like peptide Bs 8 (Bs8) (Peptide I) (Small toxin) sequence: RCKPCFTTDPQMSKKCADCCGGKGKGKCYGPQCLC | Yes | true_or_false | Biology | {
"level": "L4",
"source": "UniProtKB",
"subtask": "proteotoxicity_prediction_judgement",
"task": "proteotoxicity_prediction"
} | {
"label": [],
"text": []
} | sciknow_6a4ed4b10f32b772 | 6,632 | 20,260,428 | sciknoweval_v2_hard_autogradable_512_2026_04_28 | Biology_L4 | Biology | L4 | true_or_false | Yes | |
{
"default": "Given a true or false question, your task is to answer whether the question is true or not. Your answer should be \"Yes\" or \"No\". Please directly give the answer, DO NOT output any other characters."
} | Please determine whether the following protein is toxic.
entry: Q1B571 protein_name: Virginiamycin B lyase (EC 4.2.99.-) (Streptogramin B lyase) sequence: MSLIREIAGGPYALAAGPDGAMWVTLVHDGAIARVGADGAVDRFPVADGSRPSLISAGPDGALWFTRNGDDRIGRLTTAGELTEFPLSEGSAPFGICAGADGALWFTEMGSGGIGRITVDGQTSGWASVGGTPSMITRGPDDAVWFTLNQGNAIGRLHPRDGVTM... | No | true_or_false | Biology | {
"level": "L4",
"source": "UniProtKB",
"subtask": "proteotoxicity_prediction_judgement",
"task": "proteotoxicity_prediction"
} | {
"label": [],
"text": []
} | sciknow_c93f83d4726329d9 | 6,665 | 20,260,428 | sciknoweval_v2_hard_autogradable_512_2026_04_28 | Biology_L4 | Biology | L4 | true_or_false | No | |
{
"default": "Given a true or false question, your task is to answer whether the question is true or not. Your answer should be \"Yes\" or \"No\". Please directly give the answer, DO NOT output any other characters."
} | Please determine whether the following protein is toxic.
entry: A8QL56 protein_name: Alpha- and beta-fibrinogenase OhS1 (EC 3.4.21.-) (Snake venom serine protease) (SVSP) sequence: MALIRVLASLLILQLSYAVTPFDRIIGGFECNEYEHRSLVHLYNSSGFFCSGTLLNHEWVLTAAHCNRDDIQIKLGVHNVSVNYEDEQIRVPKEKLCCHSTNNCTQLGQDIMLIRLNSSVNYSEHIAPLSLPSNRPSMG... | Yes | true_or_false | Biology | {
"level": "L4",
"source": "UniProtKB",
"subtask": "proteotoxicity_prediction_judgement",
"task": "proteotoxicity_prediction"
} | {
"label": [],
"text": []
} | sciknow_726a0f704a91822c | 6,745 | 20,260,428 | sciknoweval_v2_hard_autogradable_512_2026_04_28 | Biology_L4 | Biology | L4 | true_or_false | Yes | |
{
"default": "Given a true or false question, your task is to answer whether the question is true or not. Your answer should be \"Yes\" or \"No\". Please directly give the answer, DO NOT output any other characters."
} | Please determine whether the following protein is toxic.
entry: P24478 protein_name: Ribosome-inactivating protein karasurin-C (EC 3.2.2.22) (rRNA N-glycosidase) [Cleaved into: Ribosome-inactivating protein karasurin-A] sequence: MIRFLVFSLLILTLFLTAPAVEGDVSFRLSGATSSSYGVFISNLRKALPYERKLYDIPLLRSTLPGSQRYALIHLTNYADETISVAIDVT... | Yes | true_or_false | Biology | {
"level": "L4",
"source": "UniProtKB",
"subtask": "proteotoxicity_prediction_judgement",
"task": "proteotoxicity_prediction"
} | {
"label": [],
"text": []
} | sciknow_d3ea57e9fc8daf6e | 6,761 | 20,260,428 | sciknoweval_v2_hard_autogradable_512_2026_04_28 | Biology_L4 | Biology | L4 | true_or_false | Yes | |
{
"default": "Given a true or false question, your task is to answer whether the question is true or not. Your answer should be \"Yes\" or \"No\". Please directly give the answer, DO NOT output any other characters."
} | Please determine whether the following protein is toxic.
entry: P14137 protein_name: Cholesterol side-chain cleavage enzyme, mitochondrial (EC 1.14.15.6) (CYPXIA1) (Cholesterol desmolase) (Cytochrome P450 11A1) (Cytochrome P450(scc)) sequence: MLAKGLCLRSVLVKSCQPFLSPVWQGPGLATGNGAGISSTNSPRSFNEIPSPGDNGWINLYHFLRENGTHRIHYHH... | No | true_or_false | Biology | {
"level": "L4",
"source": "UniProtKB",
"subtask": "proteotoxicity_prediction_judgement",
"task": "proteotoxicity_prediction"
} | {
"label": [],
"text": []
} | sciknow_79b7de7a01417167 | 6,782 | 20,260,428 | sciknoweval_v2_hard_autogradable_512_2026_04_28 | Biology_L4 | Biology | L4 | true_or_false | No | |
{
"default": "Given a true or false question, your task is to answer whether the question is true or not. Your answer should be \"Yes\" or \"No\". Please directly give the answer, DO NOT output any other characters."
} | Please determine whether the following protein is toxic.
entry: Q91ZJ9 protein_name: Hyaluronidase-1 (Hyal-1) (EC 3.2.1.35) (Hyaluronoglucosaminidase-1) sequence: MLGLTQHAQKVWRMKPFSPEVSPGSSPATAGHLLRISTLFLTLLELAQVCRGSVVSNRPFITVWNGDTHWCLTEYGVDVDVSVFDVVANKEQSFQGSNMTIFYREELGTYPYYTPTGEPVFGGLPQNASLVTHLAHTFQDIKAAMPEPDFSGLAVID... | No | true_or_false | Biology | {
"level": "L4",
"source": "UniProtKB",
"subtask": "proteotoxicity_prediction_judgement",
"task": "proteotoxicity_prediction"
} | {
"label": [],
"text": []
} | sciknow_8b67b4dc21e219a6 | 6,802 | 20,260,428 | sciknoweval_v2_hard_autogradable_512_2026_04_28 | Biology_L4 | Biology | L4 | true_or_false | No | |
{
"default": "Given a true or false question, your task is to answer whether the question is true or not. Your answer should be \"Yes\" or \"No\". Please directly give the answer, DO NOT output any other characters."
} | Please determine whether the following protein is toxic.
entry: P0A2Y9 protein_name: ATP synthase subunit a (ATP synthase F0 sector subunit a) (F-ATPase subunit 6) sequence: MEESINPIISIGPVIFNLTMLAMTLLIVGVIFVFIYWASRNMTLKPKGKQNVLEYVYDFVIGFTEPNIGSRYMKDYSLFFLCLFLFMVIANNLGLMTKLQTIDGTNWWSSPTANLQYDLTLSFLVILLTHIESVRRRGFKKSIKSF... | No | true_or_false | Biology | {
"level": "L4",
"source": "UniProtKB",
"subtask": "proteotoxicity_prediction_judgement",
"task": "proteotoxicity_prediction"
} | {
"label": [],
"text": []
} | sciknow_b89d0113af7971fd | 6,803 | 20,260,428 | sciknoweval_v2_hard_autogradable_512_2026_04_28 | Biology_L4 | Biology | L4 | true_or_false | No | |
{
"default": "Given a true or false question, your task is to answer whether the question is true or not. Your answer should be \"Yes\" or \"No\". Please directly give the answer, DO NOT output any other characters."
} | Please determine whether the following protein is toxic.
entry: O18495 protein_name: Styelin-D sequence: MQMKATILIVLVALFMIQQSEAGWLRKAAKSVGKFYYKHKYYIKAAWQIGKHALGDMTDEEFQDFMKEVEQAREEELQSRQ | No | true_or_false | Biology | {
"level": "L4",
"source": "UniProtKB",
"subtask": "proteotoxicity_prediction_judgement",
"task": "proteotoxicity_prediction"
} | {
"label": [],
"text": []
} | sciknow_da76d6518235476f | 6,807 | 20,260,428 | sciknoweval_v2_hard_autogradable_512_2026_04_28 | Biology_L4 | Biology | L4 | true_or_false | No | |
{
"default": "Given a true or false question, your task is to answer whether the question is true or not. Your answer should be \"Yes\" or \"No\". Please directly give the answer, DO NOT output any other characters."
} | Please determine whether the following protein is toxic.
entry: C0HJQ8 protein_name: Potassium channel toxin alpha-KTx 1.16 (Toxin MeKTx11-1) sequence: MKISFLLLLALVICSIGWSEAQFTDVKCTGTKQCWPVCKKMFGRPNGKCMNGKCRCYP | Yes | true_or_false | Biology | {
"level": "L4",
"source": "UniProtKB",
"subtask": "proteotoxicity_prediction_judgement",
"task": "proteotoxicity_prediction"
} | {
"label": [],
"text": []
} | sciknow_44057335be86b856 | 6,825 | 20,260,428 | sciknoweval_v2_hard_autogradable_512_2026_04_28 | Biology_L4 | Biology | L4 | true_or_false | Yes | |
{
"default": "Given a true or false question, your task is to answer whether the question is true or not. Your answer should be \"Yes\" or \"No\". Please directly give the answer, DO NOT output any other characters."
} | Please determine whether the following protein is toxic.
entry: H1ZZI8 protein_name: Toxin Tpa7 (T-beta* NaTx1.3) sequence: MKGMILLISCLMLIEVVVECKEGYPLDTLNGCKVGCFFGTNSWCNDKCKSKTAAKGYCAWPSCYCYGFTDDSKIWDLKKNKC | Yes | true_or_false | Biology | {
"level": "L4",
"source": "UniProtKB",
"subtask": "proteotoxicity_prediction_judgement",
"task": "proteotoxicity_prediction"
} | {
"label": [],
"text": []
} | sciknow_5a5f38238db7f003 | 6,834 | 20,260,428 | sciknoweval_v2_hard_autogradable_512_2026_04_28 | Biology_L4 | Biology | L4 | true_or_false | Yes | |
{
"default": "Given a true or false question, your task is to answer whether the question is true or not. Your answer should be \"Yes\" or \"No\". Please directly give the answer, DO NOT output any other characters."
} | Please determine whether the following protein is toxic.
entry: B6DD39 protein_name: U14-lycotoxin-Ls1c (Toxin-like structure LSTX-N6) sequence: MNSKVFAVLLLLALLTCILSEKYCPTPRNTSCKKMNIKNNCCRDSDCTSNAFCCAEPCGNFCHKASDKPGGRRVDPNASCQTGYVYW | No | true_or_false | Biology | {
"level": "L4",
"source": "UniProtKB",
"subtask": "proteotoxicity_prediction_judgement",
"task": "proteotoxicity_prediction"
} | {
"label": [],
"text": []
} | sciknow_c2ff39e4a674ecc6 | 6,835 | 20,260,428 | sciknoweval_v2_hard_autogradable_512_2026_04_28 | Biology_L4 | Biology | L4 | true_or_false | No | |
{
"default": "Given a true or false question, your task is to answer whether the question is true or not. Your answer should be \"Yes\" or \"No\". Please directly give the answer, DO NOT output any other characters."
} | Please determine whether the following protein is toxic.
entry: P0A4K6 protein_name: Tetracycline resistance protein sequence: MNTSYSQSNLRHNQILIWLCILSFFSVLNEMVLNVSLPDIANDFNKPPASTNWVNTAFMLTFSIGTAVYGKLSDQLGIKRLLLFGIIINCFGSVIGFVGHSFFSLLIMARFIQGAGAAAFPALVMVVVARYIPKENRGKAFGLIGSIVAMGEGVGPAIGGMIAHYIHWSYLLLIPMITIITVPFLMKLLKKEV... | No | true_or_false | Biology | {
"level": "L4",
"source": "UniProtKB",
"subtask": "proteotoxicity_prediction_judgement",
"task": "proteotoxicity_prediction"
} | {
"label": [],
"text": []
} | sciknow_a0d6efa6a63b2b31 | 6,884 | 20,260,428 | sciknoweval_v2_hard_autogradable_512_2026_04_28 | Biology_L4 | Biology | L4 | true_or_false | No | |
{
"default": "Given a true or false question, your task is to answer whether the question is true or not. Your answer should be \"Yes\" or \"No\". Please directly give the answer, DO NOT output any other characters."
} | Please determine whether the following protein is toxic.
entry: P0DH31 protein_name: Undecaprenyl-diphosphatase (EC 3.6.1.27) (Bacitracin resistance protein) (Undecaprenyl pyrophosphate phosphatase) sequence: MLIIELLKAIFFGIIEGITEWLPVSSTGHLILVQEFIRLNQDKAFIEMFNIVIQLGAIIAVMLIYFERLNPFQPGKTAREVQLTWQLWLKVVIACIPSILIAVPLDNWFEA... | No | true_or_false | Biology | {
"level": "L4",
"source": "UniProtKB",
"subtask": "proteotoxicity_prediction_judgement",
"task": "proteotoxicity_prediction"
} | {
"label": [],
"text": []
} | sciknow_f578c8aa5e81b864 | 6,893 | 20,260,428 | sciknoweval_v2_hard_autogradable_512_2026_04_28 | Biology_L4 | Biology | L4 | true_or_false | No | |
{
"default": "Please read the text carefully and choose the correct answer from the multiple-choice options based on your understanding of the details or data described. Your answer should be \"A\", \"B\", \"C\" or \"D\". Please directly give the answer without any explanation."
} | The activity series of metals, compiled by chemists, organizes metals based on their likelihood to give up an electron in redox reactions, where metals at the top of the series lose electrons most easily, and those at the bottom do so less readily. This series is useful in predicting the outcomes of chemical reactions,... | mcq-4-choices | Chemistry | {
"level": "L2",
"source": "one.libretexts",
"subtask": "reaction_mechanism_inference",
"task": "L2_Chemistry"
} | D | {
"label": [
"A",
"B",
"C",
"D"
],
"text": [
"The boiling points of metals",
"The melting points of metals",
"The solubility of metals in water",
"The outcomes of redox reactions"
]
} | sciknow_05b128f5bcd3a5f1 | 11,506 | 20,260,428 | sciknoweval_v2_hard_autogradable_512_2026_04_28 | Chemistry_L2 | Chemistry | L2 | mcq-4-choices | D | |
{
"default": "Please read the text carefully and choose the correct answer from the multiple-choice options based on your understanding of the details or data described. Your answer should be \"A\", \"B\", \"C\" or \"D\". Please directly give the answer without any explanation."
} | Migratory insertion reactions are particularly significant in industrial processes, including the manufacture of everyday products such as body wash. A common example is the synthesis of sodium laureth sulfate and related compounds, primarily through a hydroformylation process where a rhodium catalyst is typically used... | mcq-4-choices | Chemistry | {
"level": "L2",
"source": "one.libretexts",
"subtask": "reaction_mechanism_inference",
"task": "L2_Chemistry"
} | B | {
"label": [
"A",
"B",
"C",
"D"
],
"text": [
"The formation of a permanent alkyl-hydride bond",
"The migration of alkyl ligands to a carbonyl",
"The synthesis without a catalyst",
"The use of a platinum catalyst"
]
} | sciknow_363f68c61ca9bea1 | 11,514 | 20,260,428 | sciknoweval_v2_hard_autogradable_512_2026_04_28 | Chemistry_L2 | Chemistry | L2 | mcq-4-choices | B | |
{
"default": "Please read the text carefully and choose the correct answer from the multiple-choice options based on your understanding of the details or data described. Your answer should be \"A\", \"B\", \"C\" or \"D\". Please directly give the answer without any explanation."
} | The text discusses two methods of polymer preparation using olefin metathesis. The first method, ring-opening metathesis polymerization (ROMP), utilizes moderately strained cycloalkenes like cyclopentene. The strain in the cycloalkene promotes ring-opening, which facilitates the formation of a polymer with regularly sp... | mcq-4-choices | Chemistry | {
"level": "L2",
"source": "one.libretexts",
"subtask": "reaction_mechanism_inference",
"task": "L2_Chemistry"
} | B | {
"label": [
"A",
"B",
"C",
"D"
],
"text": [
"Propane",
"Ethylene",
"Methane",
"Water"
]
} | sciknow_20bf2acd2fd69015 | 11,576 | 20,260,428 | sciknoweval_v2_hard_autogradable_512_2026_04_28 | Chemistry_L2 | Chemistry | L2 | mcq-4-choices | B | |
{
"default": "Please read the text carefully and choose the correct answer from the multiple-choice options based on your understanding of the details or data described. Your answer should be \"A\", \"B\", \"C\" or \"D\". Please directly give the answer without any explanation."
} | The text provided discusses two types of chemical rearrangements: the Beckmann and Wolff rearrangements. The Beckmann Rearrangement, which is detailed on a page titled "11.4: Beckmann Rearrangement" found on the LibreTexts platform, is shared under a CC BY-NC 3.0 license. This content was authored, remixed, and/or cura... | mcq-4-choices | Chemistry | {
"level": "L2",
"source": "one.libretexts",
"subtask": "reaction_mechanism_inference",
"task": "L2_Chemistry"
} | C | {
"label": [
"A",
"B",
"C",
"D"
],
"text": [
"Diazonium salt",
"Carbocation",
"Ketene",
"Dinitrogen"
]
} | sciknow_e57a2cd4989f8d38 | 11,577 | 20,260,428 | sciknoweval_v2_hard_autogradable_512_2026_04_28 | Chemistry_L2 | Chemistry | L2 | mcq-4-choices | C | |
{
"default": "Please read the text carefully and choose the correct answer from the multiple-choice options based on your understanding of the details or data described. Your answer should be \"A\", \"B\", \"C\" or \"D\". Please directly give the answer without any explanation."
} | Acetylcholinesterase is a hydrolytic enzyme involved in the breakdown of acetylcholine, a neurotransmitter that triggers muscle contraction. The enzymatic reaction of acetylcholinesterase proceeds in two phases. Initially, a covalent enzyme-substrate intermediate is created when the acyl group of acetylcholine is trans... | mcq-4-choices | Chemistry | {
"level": "L2",
"source": "one.libretexts",
"subtask": "reaction_mechanism_inference",
"task": "L2_Chemistry"
} | B | {
"label": [
"A",
"B",
"C",
"D"
],
"text": [
"Acetylcholine",
"Covalent enzyme-substrate intermediate",
"Serine",
"Acetate"
]
} | sciknow_33d8bf96760a318e | 11,592 | 20,260,428 | sciknoweval_v2_hard_autogradable_512_2026_04_28 | Chemistry_L2 | Chemistry | L2 | mcq-4-choices | B | |
{
"default": "Please read the text carefully and choose the correct answer from the multiple-choice options based on your understanding of the details or data described. Your answer should be \"A\", \"B\", \"C\" or \"D\". Please directly give the answer without any explanation."
} | Tautomers are constitutional isomers that can rapidly and reversibly interconvert, differing mainly in the site of protonation and the location of a double bond. This process, known as tautomerization, is a common step in biological organic chemistry. Typically, in the tautomerization process, the ketone (or aldehyde) ... | mcq-4-choices | Chemistry | {
"level": "L2",
"source": "one.libretexts",
"subtask": "reaction_mechanism_inference",
"task": "L2_Chemistry"
} | C | {
"label": [
"A",
"B",
"C",
"D"
],
"text": [
"The keto form has a higher molecular weight.",
"The enol form is more reactive with other compounds.",
"The keto form has bonds that are approximately 48 kJ/mol higher in energy than those in the enol form.",
"The keto form is less solu... | sciknow_476e5307465f10d6 | 11,596 | 20,260,428 | sciknoweval_v2_hard_autogradable_512_2026_04_28 | Chemistry_L2 | Chemistry | L2 | mcq-4-choices | C | |
{
"default": "Please read the text carefully and choose the correct answer from the multiple-choice options based on your understanding of the details or data described. Your answer should be \"A\", \"B\", \"C\" or \"D\". Please directly give the answer without any explanation."
} | The Diels-Alder reaction, a notable example of a cycloaddition reaction, shares characteristics with pericyclic reactions such as the Cope rearrangement. Unlike the Cope and Claisen rearrangements that often occur intramolecularly, the Diels-Alder reaction typically occurs between two molecules, intermolecularly. It in... | mcq-4-choices | Chemistry | {
"level": "L2",
"source": "one.libretexts",
"subtask": "reaction_mechanism_inference",
"task": "L2_Chemistry"
} | A | {
"label": [
"A",
"B",
"C",
"D"
],
"text": [
"Ethene",
"Methane",
"Benzene",
"1,3-Butadiene"
]
} | sciknow_1f71bb011e1d429f | 11,708 | 20,260,428 | sciknoweval_v2_hard_autogradable_512_2026_04_28 | Chemistry_L2 | Chemistry | L2 | mcq-4-choices | A | |
{
"default": "Please read the text carefully and choose the correct answer from the multiple-choice options based on your understanding of the details or data described. Your answer should be \"A\", \"B\", \"C\" or \"D\". Please directly give the answer without any explanation."
} | Evaporative light scattering detection is primarily used in chromatographic analysis to identify the presence and retention time of non-UV-absorbing species, rather than their concentration. This technique is part of a broader method called turbidimetry, where the decrease in power from scattering by particulate matter... | mcq-4-choices | Chemistry | {
"level": "L2",
"source": "one.libretexts",
"subtask": "detailed_understanding",
"task": "L2_General"
} | D | {
"label": [
"A",
"B",
"C",
"D"
],
"text": [
"To measure the decrease in power from scattering by particulate matter",
"To control the pH of the mobile phase",
"To measure the concentration of UV-absorbing species",
"To identify the presence and retention time of non-UV-absorbing s... | sciknow_41fe8193743fbf40 | 12,183 | 20,260,428 | sciknoweval_v2_hard_autogradable_512_2026_04_28 | Chemistry_L2 | Chemistry | L2 | mcq-4-choices | D | |
{
"default": "Please read the text carefully and choose the correct answer from the multiple-choice options based on your understanding of the details or data described. Your answer should be \"A\", \"B\", \"C\" or \"D\". Please directly give the answer without any explanation."
} | Markovnikov’s rule explains that during the addition of HX to an alkene, a more stable carbocation intermediate forms. This aligns with the Hammond postulate, which posits that the transition state of an exergonic reaction resembles the reactants, while that of an endergonic reaction resembles the products. Given that ... | mcq-4-choices | Chemistry | {
"level": "L2",
"source": "one.libretexts",
"subtask": "detailed_understanding",
"task": "L2_General"
} | D | {
"label": [
"A",
"B",
"C",
"D"
],
"text": [
"Immediate formation of the final product without intermediates",
"Formation of a less stable carbocation",
"Breakdown of the alkene into simpler molecules",
"Structural rearrangements involving shifts of ions"
]
} | sciknow_656ff5f450516413 | 12,185 | 20,260,428 | sciknoweval_v2_hard_autogradable_512_2026_04_28 | Chemistry_L2 | Chemistry | L2 | mcq-4-choices | D | |
{
"default": "Please read the text carefully and choose the correct answer from the multiple-choice options based on your understanding of the details or data described. Your answer should be \"A\", \"B\", \"C\" or \"D\". Please directly give the answer without any explanation."
} | In retrosynthetic analysis, the primary task is to identify the bonds within the product that need to be broken down. Specifically, for the product in question, the crucial task is to pinpoint two disconnection points. These points are informed by the functional groups present in the product, which include two alcohol ... | mcq-4-choices | Chemistry | {
"level": "L2",
"source": "one.libretexts",
"subtask": "detailed_understanding",
"task": "L2_General"
} | A | {
"label": [
"A",
"B",
"C",
"D"
],
"text": [
"Cyclic hemiketal",
"Alcohol group",
"Ketone",
"Methyl ether"
]
} | sciknow_9e6703989aeb4fb6 | 12,213 | 20,260,428 | sciknoweval_v2_hard_autogradable_512_2026_04_28 | Chemistry_L2 | Chemistry | L2 | mcq-4-choices | A | |
{
"default": "Please read the text carefully and choose the correct answer from the multiple-choice options based on your understanding of the details or data described. Your answer should be \"A\", \"B\", \"C\" or \"D\". Please directly give the answer without any explanation."
} | Polyacrylamide gels are employed in separating small nucleic acid fragments, including those where DNA pieces differ by only one nucleotide. In protein analysis, proteins must be modified to interact effectively with these gels. This is achieved by treating proteins with the anionic detergent sodium dodecyl sulfate (SD... | mcq-4-choices | Chemistry | {
"level": "L2",
"source": "one.libretexts",
"subtask": "detailed_understanding",
"task": "L2_General"
} | B | {
"label": [
"A",
"B",
"C",
"D"
],
"text": [
"To fragment the proteins into smaller pieces",
"To denature the proteins and give them a uniform negative charge",
"To increase the molecular weight of the proteins",
"To enhance the natural positive charge of proteins"
]
} | sciknow_99525a4ace1d7517 | 12,239 | 20,260,428 | sciknoweval_v2_hard_autogradable_512_2026_04_28 | Chemistry_L2 | Chemistry | L2 | mcq-4-choices | B | |
{
"default": "Please read the text carefully and choose the correct answer from the multiple-choice options based on your understanding of the details or data described. Your answer should be \"A\", \"B\", \"C\" or \"D\". Please directly give the answer without any explanation."
} | The text discusses the concept of deviation from Beer's Law due to differences in molar absorptivity at various wavelengths. It explains that when comparing two wavelengths, the greater the difference in their molar absorptivities, the more significant the negative deviation observed. Examples provided include scenario... | mcq-4-choices | Chemistry | {
"level": "L2",
"source": "one.libretexts",
"subtask": "detailed_understanding",
"task": "L2_General"
} | C | {
"label": [
"A",
"B",
"C",
"D"
],
"text": [
"The selection of wavelengths with identical peak shapes",
"The use of wavelengths where molar absorptivities are both zero",
"Larger differences in molar absorptivities at different wavelengths",
"Smaller differences in molar absorptivi... | sciknow_58ad15c0aa4980ff | 12,269 | 20,260,428 | sciknoweval_v2_hard_autogradable_512_2026_04_28 | Chemistry_L2 | Chemistry | L2 | mcq-4-choices | C | |
{
"default": "Please read the text carefully and choose the correct answer from the multiple-choice options based on your understanding of the details or data described. Your answer should be \"A\", \"B\", \"C\" or \"D\". Please directly give the answer without any explanation."
} | Intermolecular forces are electrostatic in nature and include van der Waals forces and hydrogen bonds. These forces are crucial in holding molecules together in liquids, which are weaker compared to the intramolecular interactions that bind atoms within molecules and polyatomic ions. The three primary types of intermol... | mcq-4-choices | Chemistry | {
"level": "L2",
"source": "one.libretexts",
"subtask": "detailed_understanding",
"task": "L2_General"
} | D | {
"label": [
"A",
"B",
"C",
"D"
],
"text": [
"HCl",
"He",
"Ne",
"HF"
]
} | sciknow_ee39ce93262ff1bb | 12,341 | 20,260,428 | sciknoweval_v2_hard_autogradable_512_2026_04_28 | Chemistry_L2 | Chemistry | L2 | mcq-4-choices | D | |
{
"default": "Please read the text carefully and choose the correct answer from the multiple-choice options based on your understanding of the details or data described. Your answer should be \"A\", \"B\", \"C\" or \"D\". Please directly give the answer without any explanation."
} | The text provides insights into the solid-state structures and bonding characteristics of various chemical compounds, particularly focusing on organometallic compounds and comparing them to binary hydrogen compounds. It notes that alkyl groups in compounds like alkyl lithium (MeLi) and alkyl aluminum (AlMe) tend to avo... | mcq-4-choices | Chemistry | {
"level": "L2",
"source": "one.libretexts",
"subtask": "detailed_understanding",
"task": "L2_General"
} | D | {
"label": [
"A",
"B",
"C",
"D"
],
"text": [
"Alkyl groups form simpler molecular structures.",
"Alkyl groups prefer the rock-salt structure.",
"Alkyl groups form stronger ionic bonds.",
"Alkyl groups avoid ionic bonding, leading to different structures."
]
} | sciknow_66d8b7f34e6a3703 | 12,348 | 20,260,428 | sciknoweval_v2_hard_autogradable_512_2026_04_28 | Chemistry_L2 | Chemistry | L2 | mcq-4-choices | D | |
{
"default": "Please read the text carefully and choose the correct answer from the multiple-choice options based on your understanding of the details or data described. Your answer should be \"A\", \"B\", \"C\" or \"D\". Please directly give the answer without any explanation."
} | In trigonal bipyramidal electron-pair geometries, there are two distinct types of positions: axial and equatorial. The axial position, which allows the molecule to be rotated around an axis when held by these positions, is characterized by 90° bond angles. Conversely, the equatorial position, forming an equator around ... | mcq-4-choices | Chemistry | {
"level": "L2",
"source": "one.libretexts",
"subtask": "detailed_understanding",
"task": "L2_General"
} | A | {
"label": [
"A",
"B",
"C",
"D"
],
"text": [
"Because axial positions have smaller bond angles of 90°, offering less space",
"Because equatorial positions are less stable and need to be balanced by lone pairs",
"Because axial positions are on the molecule's axis and cannot accommodate ... | sciknow_7ad4f1fee2f1c0c0 | 12,353 | 20,260,428 | sciknoweval_v2_hard_autogradable_512_2026_04_28 | Chemistry_L2 | Chemistry | L2 | mcq-4-choices | A | |
{
"default": "Please read the text carefully and choose the correct answer from the multiple-choice options based on your understanding of the details or data described. Your answer should be \"A\", \"B\", \"C\" or \"D\". Please directly give the answer without any explanation."
} | The text describes a method for calculating the ratio of different molecules in a sample using their respective NMR (Nuclear Magnetic Resonance) integrals and the number of hydrogens per molecule. For example, benzene, which shows a peak at 7.15 ppm with an integral of 1H, actually represents 0.17 molecules when divide... | mcq-4-choices | Chemistry | {
"level": "L2",
"source": "one.libretexts",
"subtask": "detailed_understanding",
"task": "L2_General"
} | D | {
"label": [
"A",
"B",
"C",
"D"
],
"text": [
"By multiplying the integral values by the number of hydrogens per molecule",
"By directly using the integral values as the quantity of molecules",
"By dividing the integral values by the molecular weight of each molecule",
"By dividing ... | sciknow_e78d1ea3f3a25b44 | 12,402 | 20,260,428 | sciknoweval_v2_hard_autogradable_512_2026_04_28 | Chemistry_L2 | Chemistry | L2 | mcq-4-choices | D | |
{
"default": "Please read the text carefully and choose the correct answer from the multiple-choice options based on your understanding of the details or data described. Your answer should be \"A\", \"B\", \"C\" or \"D\". Please directly give the answer without any explanation."
} | The ABX perovskite structure consists of three types of ions, designated as A, B, and X, which are represented by the colors white, blue, and red, respectively. Understanding the coordination of the A ions in the perovskite structure can be facilitated by examining the ReO structure, which is essentially the same but l... | mcq-4-choices | Chemistry | {
"level": "L2",
"source": "one.libretexts",
"subtask": "detailed_understanding",
"task": "L2_General"
} | D | {
"label": [
"A",
"B",
"C",
"D"
],
"text": [
"8",
"10",
"14",
"12"
]
} | sciknow_281b77515dfc5776 | 12,419 | 20,260,428 | sciknoweval_v2_hard_autogradable_512_2026_04_28 | Chemistry_L2 | Chemistry | L2 | mcq-4-choices | D | |
{
"default": "Please read the text carefully and choose the correct answer from the multiple-choice options based on your understanding of the details or data described. Your answer should be \"A\", \"B\", \"C\" or \"D\". Please directly give the answer without any explanation."
} | The Fischer and Schrock carbyne systems are notable for their carbyne moieties existing in different spin states, with the Fischer carbynes in a doublet state and the Schrock carbynes in a quartet state. These carbyne complexes are typically synthesized from their corresponding carbene analogues through several methods... | mcq-4-choices | Chemistry | {
"level": "L2",
"source": "one.libretexts",
"subtask": "detailed_understanding",
"task": "L2_General"
} | C | {
"label": [
"A",
"B",
"C",
"D"
],
"text": [
"Both Fischer and Schrock carbynes are in a quartet state",
"Both Fischer and Schrock carbynes are in a doublet state",
"Fischer carbynes are in a doublet state, and Schrock carbynes are in a quartet state",
"Fischer carbynes are in a qu... | sciknow_5861d38df082f92f | 12,426 | 20,260,428 | sciknoweval_v2_hard_autogradable_512_2026_04_28 | Chemistry_L2 | Chemistry | L2 | mcq-4-choices | C | |
{
"default": "Please read the text carefully and choose the correct answer from the multiple-choice options based on your understanding of the details or data described. Your answer should be \"A\", \"B\", \"C\" or \"D\". Please directly give the answer without any explanation."
} | In silica, an extended three-dimensional solid, examining sub-structures such as "chains" of silica tetrahedra reveals a notable pattern. These tetrahedra are connected in a way that creates a spiral configuration, where each tetrahedron is slightly twisted in relation to the previous one. This sequence repeats every f... | mcq-4-choices | Chemistry | {
"level": "L2",
"source": "one.libretexts",
"subtask": "detailed_understanding",
"task": "L2_General"
} | B | {
"label": [
"A",
"B",
"C",
"D"
],
"text": [
"Linearly without any twist",
"In a helical pattern by twisting each subsequent tetrahedron",
"In parallel rows with direct alignments",
"Randomly without any specific pattern"
]
} | sciknow_4567bc16580980bb | 12,500 | 20,260,428 | sciknoweval_v2_hard_autogradable_512_2026_04_28 | Chemistry_L2 | Chemistry | L2 | mcq-4-choices | B | |
{
"default": "Please read the text carefully and choose the correct answer from the multiple-choice options based on your understanding of the details or data described. Your answer should be \"A\", \"B\", \"C\" or \"D\". Please directly give the answer without any explanation."
} | The text discusses the use of metal-ion complexes in hydrolytic reactions, specifically focusing on zinc and its advantages in reducing mechanistic ambiguities due to its inert nature. This property of zinc helps prevent equilibration among isomeric structures during reactions, thus simplifying the interpretation of re... | mcq-4-choices | Chemistry | {
"level": "L2",
"source": "one.libretexts",
"subtask": "detailed_understanding",
"task": "L2_General"
} | B | {
"label": [
"A",
"B",
"C",
"D"
],
"text": [
"Its ability to emulate enzymatic functions alone",
"Its inert nature which reduces mechanistic ambiguities",
"Its ability to equilibrate quickly with isomeric structures",
"Its role in accelerating amide hydrolysis"
]
} | sciknow_69aa18e5b9f64624 | 12,564 | 20,260,428 | sciknoweval_v2_hard_autogradable_512_2026_04_28 | Chemistry_L2 | Chemistry | L2 | mcq-4-choices | B | |
{
"default": "Please read the text carefully and choose the correct answer from the multiple-choice options based on your understanding of the details or data described. Your answer should be \"A\", \"B\", \"C\" or \"D\". Please directly give the answer without any explanation."
} | Many pericyclic reactions are reversible, often named by adding the prefix "retro" to the forward reaction's name. For instance, a Diels-Alder reaction and its reverse, termed retro-Diels-Alder reaction, typically occur under different temperature conditions. Diels-Alder reactions generally take place at low or moderat... | mcq-4-choices | Chemistry | {
"level": "L2",
"source": "one.libretexts",
"subtask": "detailed_understanding",
"task": "L2_General"
} | B | {
"label": [
"A",
"B",
"C",
"D"
],
"text": [
"Exactly at 100°C",
"Between 25°C and 100°C",
"Below 25°C",
"Above 200°C"
]
} | sciknow_c3a8c30dc015dbe3 | 12,568 | 20,260,428 | sciknoweval_v2_hard_autogradable_512_2026_04_28 | Chemistry_L2 | Chemistry | L2 | mcq-4-choices | B | |
{
"default": "Please read the text carefully and choose the correct answer from the multiple-choice options based on your understanding of the details or data described. Your answer should be \"A\", \"B\", \"C\" or \"D\". Please directly give the answer without any explanation."
} | The text provides an overview of the content found on two specific pages within the LibreTexts platform, both of which are shared under a CC BY-NC 3.0 license and were authored, remixed, and/or curated by Chris Schaller. The first page, titled "10.12: Solutions to Selected Problems," includes exercises and their soluti... | mcq-4-choices | Chemistry | {
"level": "L2",
"source": "one.libretexts",
"subtask": "detailed_understanding",
"task": "L2_General"
} | B | {
"label": [
"A",
"B",
"C",
"D"
],
"text": [
"Introduction and detailed discussion of solutions to general chemistry problems",
"Overview of various types of electrophilic rearrangement reactions and related problems",
"Biographical information about the author and contributors of the ... | sciknow_08035a6fe5b44380 | 12,605 | 20,260,428 | sciknoweval_v2_hard_autogradable_512_2026_04_28 | Chemistry_L2 | Chemistry | L2 | mcq-4-choices | B | |
{
"default": "Please read the text carefully and choose the correct answer from the multiple-choice options based on your understanding of the details or data described. Your answer should be \"A\", \"B\", \"C\" or \"D\". Please directly give the answer without any explanation."
} | Ionic bonding involves the interaction between fully charged species, which can be either monatomic or polyatomic ions. Monatomic ions, such as sodium (Na) or chlorine (Cl), are formed through the gain or loss of electrons. Polyatomic ions, like ammonium (NH4+) and acetate (CH3COO-), typically arise from molecules gain... | mcq-4-choices | Chemistry | {
"level": "L2",
"source": "one.libretexts",
"subtask": "detailed_understanding",
"task": "L2_General"
} | C | {
"label": [
"A",
"B",
"C",
"D"
],
"text": [
"Polyatomic ions cannot participate in the formation of molecular salts, unlike monatomic ions.",
"Monatomic ions are formed by the gain or loss of protons, while polyatomic ions are formed by the gain or loss of electrons.",
"Monatomic ions... | sciknow_f8baa4fd5bcd237a | 12,667 | 20,260,428 | sciknoweval_v2_hard_autogradable_512_2026_04_28 | Chemistry_L2 | Chemistry | L2 | mcq-4-choices | C | |
{
"default": "Please read the text carefully and choose the correct answer from the multiple-choice options based on your understanding of the details or data described. Your answer should be \"A\", \"B\", \"C\" or \"D\". Please directly give the answer without any explanation."
} | In hydrogen nuclear magnetic resonance (H NMR) spectroscopy, a common issue arises from overlapping signals of nonequivalent protons within a molecule, as seen in the spectrum of toluene (methylbenzene). This compound displays a complex pattern where the five aromatic ring protons, though nonequivalent, overlap acciden... | mcq-4-choices | Chemistry | {
"level": "L2",
"source": "one.libretexts",
"subtask": "detailed_understanding",
"task": "L2_General"
} | C | {
"label": [
"A",
"B",
"C",
"D"
],
"text": [
"Simple n + 1 splitting rule applying to all signals",
"Overlapping signals of equivalent protons",
"Splitting of signals by interactions with two or more nonequivalent protons",
"Identical chemical environments for all protons"
]
} | sciknow_97d37dac6b97c955 | 12,679 | 20,260,428 | sciknoweval_v2_hard_autogradable_512_2026_04_28 | Chemistry_L2 | Chemistry | L2 | mcq-4-choices | C | |
{
"default": "Please read the text carefully and choose the correct answer from the multiple-choice options based on your understanding of the details or data described. Your answer should be \"A\", \"B\", \"C\" or \"D\". Please directly give the answer without any explanation."
} | The relationship between the standard reduction potential and the hydrophobicity of the weakly coordinating ligand in the metal binding region is linear with a positive slope, indicating that increasing hydrophobicity increases the reduction potential. This trend was also observed in double mutants, including those inv... | mcq-4-choices | Chemistry | {
"level": "L2",
"source": "one.libretexts",
"subtask": "detailed_understanding",
"task": "L2_General"
} | D | {
"label": [
"A",
"B",
"C",
"D"
],
"text": [
"A quadratic relationship",
"No significant relationship",
"An inverse relationship with a negative slope",
"A linear relationship with a positive slope"
]
} | sciknow_caf76c3f7b8d9bc5 | 12,683 | 20,260,428 | sciknoweval_v2_hard_autogradable_512_2026_04_28 | Chemistry_L2 | Chemistry | L2 | mcq-4-choices | D | |
{
"default": "Please read the text carefully and choose the correct answer from the multiple-choice options based on your understanding of the details or data described. Your answer should be \"A\", \"B\", \"C\" or \"D\". Please directly give the answer without any explanation."
} | In the naming of alcohols according to IUPAC rules, the position of the OH group is indicated by a prefix number before the name of the parent hydrocarbon, and the parent alkane's '-e' ending is replaced by '-ol'. For cyclic alcohols, the carbon atom with the OH group is designated as C1, but the '1' is generally not i... | mcq-4-choices | Chemistry | {
"level": "L2",
"source": "one.libretexts",
"subtask": "detailed_understanding",
"task": "L2_General"
} | D | {
"label": [
"A",
"B",
"C",
"D"
],
"text": [
"No numbers are used in the naming of cyclic alcohols.",
"The number is always included before the OH group.",
"The highest number possible is assigned to the carbon with the OH group.",
"The carbon atom with the OH group is designated a... | sciknow_29dd478beb6b6764 | 12,746 | 20,260,428 | sciknoweval_v2_hard_autogradable_512_2026_04_28 | Chemistry_L2 | Chemistry | L2 | mcq-4-choices | D | |
{
"default": "You will be presented with a hypothesis or conjecture. Based on the information provided in a text excerpt or your general knowledge, determine if the hypothesis is true (yes) or false (no). Your answer should be \"Yes\" or \"No\". Please directly give the answer, DO NOT output any other characters."
} | In rotational symmetry operations, the symbol \( C_n \) represents a proper rotation, where \( n \) denotes the order of the rotational axis. The operation \( C_n \) involves rotating by an angle of \( \frac{360^\circ \times m}{n} \), with \( m \) indicating the number of times the operation is executed. When \( m = n ... | Yes | true_or_false | Chemistry | {
"level": "L2",
"source": "one.libretexts",
"subtask": "hypothesis_verification",
"task": "L2_General"
} | {
"label": [],
"text": []
} | sciknow_68ae264844025e95 | 12,839 | 20,260,428 | sciknoweval_v2_hard_autogradable_512_2026_04_28 | Chemistry_L2 | Chemistry | L2 | true_or_false | Yes | |
{
"default": "You will be presented with a hypothesis or conjecture. Based on the information provided in a text excerpt or your general knowledge, determine if the hypothesis is true (yes) or false (no). Your answer should be \"Yes\" or \"No\". Please directly give the answer, DO NOT output any other characters."
} | The atomic mass of hydrogen (H) is 1.008, and the atomic mass of oxygen (O) is 15.999, which are also their molar masses respectively. The molar mass of molecules of an element is calculated by summing the atomic masses of the atoms in the molecule. For instance, molecular hydrogen (H2) has a molar mass of 2.016, deriv... | Yes | true_or_false | Chemistry | {
"level": "L2",
"source": "one.libretexts",
"subtask": "hypothesis_verification",
"task": "L2_General"
} | {
"label": [],
"text": []
} | sciknow_e278b09d2b9ae0f7 | 12,842 | 20,260,428 | sciknoweval_v2_hard_autogradable_512_2026_04_28 | Chemistry_L2 | Chemistry | L2 | true_or_false | Yes | |
{
"default": "You will be presented with a hypothesis or conjecture. Based on the information provided in a text excerpt or your general knowledge, determine if the hypothesis is true (yes) or false (no). Your answer should be \"Yes\" or \"No\". Please directly give the answer, DO NOT output any other characters."
} | To isolate pure dialkyl magnesium from an equilibrium mixture of a Grignard reagent, which typically consists of dialkylmagnesium and magnesium halide, the treatment with dioxane can be applied. This process leads to the precipitation of magnesium halide complexed with dioxane, such as MgCl(dioxane) when the halide is ... | Yes | true_or_false | Chemistry | {
"level": "L2",
"source": "one.libretexts",
"subtask": "hypothesis_verification",
"task": "L2_General"
} | {
"label": [],
"text": []
} | sciknow_058aedbd829d7eb9 | 12,930 | 20,260,428 | sciknoweval_v2_hard_autogradable_512_2026_04_28 | Chemistry_L2 | Chemistry | L2 | true_or_false | Yes | |
{
"default": "You will be presented with a hypothesis or conjecture. Based on the information provided in a text excerpt or your general knowledge, determine if the hypothesis is true (yes) or false (no). Your answer should be \"Yes\" or \"No\". Please directly give the answer, DO NOT output any other characters."
} | The elements in the periodic table can be classified based on their properties and location. They are categorized into metals (good conductors of heat and electricity, shaded yellow), nonmetals (dull appearance, poor conductors of heat and electricity, shaded green), and metalloids (moderate conductors of heat and elec... | Yes | true_or_false | Chemistry | {
"level": "L2",
"source": "one.libretexts",
"subtask": "hypothesis_verification",
"task": "L2_General"
} | {
"label": [],
"text": []
} | sciknow_c49559278dcf184c | 13,054 | 20,260,428 | sciknoweval_v2_hard_autogradable_512_2026_04_28 | Chemistry_L2 | Chemistry | L2 | true_or_false | Yes | |
{
"default": "You will be presented with a hypothesis or conjecture. Based on the information provided in a text excerpt or your general knowledge, determine if the hypothesis is true (yes) or false (no). Your answer should be \"Yes\" or \"No\". Please directly give the answer, DO NOT output any other characters."
} | The half-life of chymotrypsin activity varies in water and octane, with significant changes observed in enzyme specificity when moving from a hydrophilic (water) to a hydrophobic (octane) solvent. The net binding energy, crucial for enzyme specificity, depends on the displacement of water from the active site during su... | No | true_or_false | Chemistry | {
"level": "L2",
"source": "one.libretexts",
"subtask": "hypothesis_verification",
"task": "L2_General"
} | {
"label": [],
"text": []
} | sciknow_1e930d3572f2b6d1 | 13,097 | 20,260,428 | sciknoweval_v2_hard_autogradable_512_2026_04_28 | Chemistry_L2 | Chemistry | L2 | true_or_false | No | |
{
"default": "You will be presented with a hypothesis or conjecture. Based on the information provided in a text excerpt or your general knowledge, determine if the hypothesis is true (yes) or false (no). Your answer should be \"Yes\" or \"No\". Please directly give the answer, DO NOT output any other characters."
} | The text discusses different lattice structures and how atoms or formula units are placed in these structures. For instance, in the body-centered cubic (bcc) structure of sodium metal, an atom is placed at each corner lattice point and one in the center of the unit cell. In the face-centered cubic (fcc) lattice of the ... | No | true_or_false | Chemistry | {
"level": "L2",
"source": "one.libretexts",
"subtask": "hypothesis_verification",
"task": "L2_General"
} | {
"label": [],
"text": []
} | sciknow_1b42a537f4b36039 | 13,168 | 20,260,428 | sciknoweval_v2_hard_autogradable_512_2026_04_28 | Chemistry_L2 | Chemistry | L2 | true_or_false | No | |
{
"default": "You are an expert chemist. Given a chemical equation, please balance the equation without any explanation and maintain the order of reactants and products as given."
} | Here is a unbalanced chemical equation:
Na2ZnO2 + HNO3 = Zn(NO3)2 + NaNO3 + H2O
The balanced chemical equation is: | Na2ZnO2 + 4HNO3 = Zn(NO3)2 + 2NaNO3 + 2H2O | filling | Chemistry | {
"level": "L3",
"source": "web",
"subtask": "balancing_chemical_equation",
"task": "balancing_chemical_equation"
} | {
"label": [],
"text": []
} | sciknow_f3033aaff5c0d75b | 13,250 | 20,260,428 | sciknoweval_v2_hard_autogradable_512_2026_04_28 | Chemistry_L3 | Chemistry | L3 | filling | Na2ZnO2 + 4HNO3 = Zn(NO3)2 + 2NaNO3 + 2H2O | |
{
"default": "You are an expert chemist. Given a chemical equation, please balance the equation without any explanation and maintain the order of reactants and products as given."
} | Here is a unbalanced chemical equation:
HCl + Br2 = BrCl + H
The balanced chemical equation is: | 2HCl + Br2 = 2BrCl + 2H | filling | Chemistry | {
"level": "L3",
"source": "web",
"subtask": "balancing_chemical_equation",
"task": "balancing_chemical_equation"
} | {
"label": [],
"text": []
} | sciknow_e0fed45d451a4822 | 13,262 | 20,260,428 | sciknoweval_v2_hard_autogradable_512_2026_04_28 | Chemistry_L3 | Chemistry | L3 | filling | 2HCl + Br2 = 2BrCl + 2H | |
{
"default": "You are an expert chemist. Given a chemical equation, please balance the equation without any explanation and maintain the order of reactants and products as given."
} | Here is a unbalanced chemical equation:
NH4Cl(aq) + Be(NO3)2(aq) = NH4NO3 + BeCl2
The balanced chemical equation is: | 2NH4Cl(aq) + Be(NO3)2(aq) = 2NH4NO3 + BeCl2 | filling | Chemistry | {
"level": "L3",
"source": "web",
"subtask": "balancing_chemical_equation",
"task": "balancing_chemical_equation"
} | {
"label": [],
"text": []
} | sciknow_b79d93c9192de23a | 13,382 | 20,260,428 | sciknoweval_v2_hard_autogradable_512_2026_04_28 | Chemistry_L3 | Chemistry | L3 | filling | 2NH4Cl(aq) + Be(NO3)2(aq) = 2NH4NO3 + BeCl2 | |
{
"default": "You are an expert chemist. Given a chemical equation, please balance the equation without any explanation and maintain the order of reactants and products as given."
} | Here is a unbalanced chemical equation:
C4H10O(l) + O2(g) = CO2(g) + H2O(g)
The balanced chemical equation is: | C4H10O(l) + 6O2(g) = 4CO2(g) + 5H2O(g) | filling | Chemistry | {
"level": "L3",
"source": "web",
"subtask": "balancing_chemical_equation",
"task": "balancing_chemical_equation"
} | {
"label": [],
"text": []
} | sciknow_128df0bd03afc178 | 13,406 | 20,260,428 | sciknoweval_v2_hard_autogradable_512_2026_04_28 | Chemistry_L3 | Chemistry | L3 | filling | C4H10O(l) + 6O2(g) = 4CO2(g) + 5H2O(g) | |
{
"default": "You are an expert chemist. Given a chemical equation, please balance the equation without any explanation and maintain the order of reactants and products as given."
} | Here is a unbalanced chemical equation:
N2O5 = N2 + O2
The balanced chemical equation is: | 2N2O5 = 2N2 + 5O2 | filling | Chemistry | {
"level": "L3",
"source": "web",
"subtask": "balancing_chemical_equation",
"task": "balancing_chemical_equation"
} | {
"label": [],
"text": []
} | sciknow_a37803d355bf1c19 | 13,436 | 20,260,428 | sciknoweval_v2_hard_autogradable_512_2026_04_28 | Chemistry_L3 | Chemistry | L3 | filling | 2N2O5 = 2N2 + 5O2 | |
{
"default": "You are an expert chemist. Given a chemical equation, please balance the equation without any explanation and maintain the order of reactants and products as given."
} | Here is a unbalanced chemical equation:
C3H6O + AgNO3 = Ag + N2 + CO2 + H2O
The balanced chemical equation is: | 3C3H6O + 8AgNO3 = 8Ag + 4N2 + 9CO2 + 9H2O | filling | Chemistry | {
"level": "L3",
"source": "web",
"subtask": "balancing_chemical_equation",
"task": "balancing_chemical_equation"
} | {
"label": [],
"text": []
} | sciknow_7009fe15585427db | 13,458 | 20,260,428 | sciknoweval_v2_hard_autogradable_512_2026_04_28 | Chemistry_L3 | Chemistry | L3 | filling | 3C3H6O + 8AgNO3 = 8Ag + 4N2 + 9CO2 + 9H2O | |
{
"default": "Given a question and four options, please select the right answer. Your answer should be \"A\", \"B\", \"C\" or \"D\". Please directly give the answer without any explanation."
} | What is the molar weight (g/mol) of the molecule with the the IUPAC name '(2S)-2-[[(2S)-2-[[(2R)-2-(2,4-dioxo-1H-quinazolin-3-yl)-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]propanoic acid'? | mcq-4-choices | Chemistry | {
"level": "L3",
"source": "PubChem",
"subtask": "i2w",
"task": "molar_weight_calculation"
} | A | {
"label": [
"A",
"B",
"C",
"D"
],
"text": [
"528.600",
"577.700",
"520.600",
"596.700"
]
} | sciknow_04a9b68e8fad58f1 | 13,819 | 20,260,428 | sciknoweval_v2_hard_autogradable_512_2026_04_28 | Chemistry_L3 | Chemistry | L3 | mcq-4-choices | A | |
{
"default": "Given a question and four options, please select the right answer. Your answer should be \"A\", \"B\", \"C\" or \"D\". Please directly give the answer without any explanation."
} | What is the molar weight (g/mol) of the molecule with the the IUPAC name '(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-1-[(2S)-2-[[(2S)-2-[[(2S)-1-[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-1-[(2S,3R)-2-[[(2S)-2-amino-3-hydroxypropanoyl]amino]-3-hydroxybutanoyl]pyrrolidine-2-carbonyl]amino]-4-methylpentanoyl]amino]-4-methylsulfanylb... | mcq-4-choices | Chemistry | {
"level": "L3",
"source": "PubChem",
"subtask": "i2w",
"task": "molar_weight_calculation"
} | A | {
"label": [
"A",
"B",
"C",
"D"
],
"text": [
"1559.800",
"1547.900",
"1572.100",
"1581.700"
]
} | sciknow_31467a9ea2c63cd1 | 13,941 | 20,260,428 | sciknoweval_v2_hard_autogradable_512_2026_04_28 | Chemistry_L3 | Chemistry | L3 | mcq-4-choices | A | |
{
"default": "Given a question and four options, please select the right answer. Your answer should be \"A\", \"B\", \"C\" or \"D\". Please directly give the answer without any explanation."
} | What is the molar weight (g/mol) of the molecule with the the IUPAC name '(2S)-2-[[4-[(2-amino-4-oxo-3H-pteridin-6-yl)methylamino]benzoyl]amino]-5-[[(1S)-1-carboxybut-3-ynyl]amino]-5-oxopentanoic acid'? | mcq-4-choices | Chemistry | {
"level": "L3",
"source": "PubChem",
"subtask": "i2w",
"task": "molar_weight_calculation"
} | A | {
"label": [
"A",
"B",
"C",
"D"
],
"text": [
"536.500",
"790.200",
"699.200",
"616.700"
]
} | sciknow_632422a03ac6b8b0 | 13,944 | 20,260,428 | sciknoweval_v2_hard_autogradable_512_2026_04_28 | Chemistry_L3 | Chemistry | L3 | mcq-4-choices | A | |
{
"default": "Given a question and four options, please select the right answer. Your answer should be \"A\", \"B\", \"C\" or \"D\". Please directly give the answer without any explanation."
} | What is the molar weight (g/mol) of the molecule with the the IUPAC name '(2S)-2-[[(2S,4R)-1-[(2S)-2-acetamido-3-(4-hydroxyphenyl)propanoyl]-4-hydroxypyrrolidine-2-carbonyl]amino]-N-[(2S,3R)-1-[[(2S)-1-[amino-[2-[[(2S)-1-[[(2S)-1-[[(2S)-1-amino-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxo... | mcq-4-choices | Chemistry | {
"level": "L3",
"source": "PubChem",
"subtask": "i2w",
"task": "molar_weight_calculation"
} | C | {
"label": [
"A",
"B",
"C",
"D"
],
"text": [
"1238.400",
"1281.400",
"1239.400",
"1242.400"
]
} | sciknow_aaba795641045bd5 | 13,945 | 20,260,428 | sciknoweval_v2_hard_autogradable_512_2026_04_28 | Chemistry_L3 | Chemistry | L3 | mcq-4-choices | C | |
{
"default": "Given a question and four options, please select the right answer. Your answer should be \"A\", \"B\", \"C\" or \"D\". Please directly give the answer without any explanation."
} | What is the molar weight (g/mol) of the molecule with the the IUPAC name '(2S)-2-[[(2S)-1-[(3R)-2-[(2S)-2-[[(3R)-3-[(2-aminoacetyl)amino]-4-[[(2S)-1-[(3R)-3-[(2S)-2-[[(1S)-1-carboxy-4-(diaminomethylideneamino)butyl]carbamoyl]-2,3,3a,4,5,6,7,7a-octahydroindole-1-carbonyl]-3,4-dihydro-1H-isoquinolin-2-yl]-3-hydroxy-1-oxo... | mcq-4-choices | Chemistry | {
"level": "L3",
"source": "PubChem",
"subtask": "i2w",
"task": "molar_weight_calculation"
} | B | {
"label": [
"A",
"B",
"C",
"D"
],
"text": [
"1377.600",
"1297.500",
"1360.500",
"1345.400"
]
} | sciknow_0e16afbc1dd92338 | 13,955 | 20,260,428 | sciknoweval_v2_hard_autogradable_512_2026_04_28 | Chemistry_L3 | Chemistry | L3 | mcq-4-choices | B | |
{
"default": "Given a question and four options, please select the right answer. Your answer should be \"A\", \"B\", \"C\" or \"D\". Please directly give the answer without any explanation."
} | What is the molar weight (g/mol) of the molecule with the the IUPAC name '(2S)-2-[[(2S)-2-[[(2S,3R)-2-[[(2S,3S)-2-[[(2S)-5-amino-2-[[(2S)-1-[(2S)-2-[[(2S)-4-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S,3R)-2-amino-3-hydroxybutanoyl]amino]-3-methylbutanoyl]amino]-3-hydroxypropanoyl]amino]-3-phenylpropanoyl]amino]-4-oxobutan... | mcq-4-choices | Chemistry | {
"level": "L3",
"source": "PubChem",
"subtask": "i2w",
"task": "molar_weight_calculation"
} | B | {
"label": [
"A",
"B",
"C",
"D"
],
"text": [
"1494.700",
"1452.700",
"1473.600",
"1486.700"
]
} | sciknow_3e27fdc8f6d084cf | 13,961 | 20,260,428 | sciknoweval_v2_hard_autogradable_512_2026_04_28 | Chemistry_L3 | Chemistry | L3 | mcq-4-choices | B | |
{
"default": "Given a question and four options, please select the right answer. Your answer should be \"A\", \"B\", \"C\" or \"D\". Please directly give the answer without any explanation."
} | What is the molar weight (g/mol) of the molecule with the the IUPAC name '(2S)-2-[[(2S)-1-[(2S)-2-[[(2S)-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-5-amino-2-[[2-[[(2S,3S)-2-amino-3-methylpentanoyl]amino]acetyl]amino]-5-oxopentanoyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]-3-hydroxypropanoyl]amino]hexanoyl]amino]-3-(1... | mcq-4-choices | Chemistry | {
"level": "L3",
"source": "PubChem",
"subtask": "i2w",
"task": "molar_weight_calculation"
} | D | {
"label": [
"A",
"B",
"C",
"D"
],
"text": [
"1222.400",
"1232.300",
"1214.400",
"1217.300"
]
} | sciknow_4d19f965cb798922 | 13,964 | 20,260,428 | sciknoweval_v2_hard_autogradable_512_2026_04_28 | Chemistry_L3 | Chemistry | L3 | mcq-4-choices | D | |
{
"default": "Given a question and four options, please select the right answer. Your answer should be \"A\", \"B\", \"C\" or \"D\". Please directly give the answer without any explanation."
} | What is the molar weight (g/mol) of the molecule with the the IUPAC name '(2S)-2-amino-N-[(2R)-1-(4-butanoyl-4-phenylpiperidin-1-yl)-3-(4-methoxyphenyl)-1-oxopropan-2-yl]-3-(3-methylimidazol-4-yl)propanamide'? | mcq-4-choices | Chemistry | {
"level": "L3",
"source": "PubChem",
"subtask": "i2w",
"task": "molar_weight_calculation"
} | D | {
"label": [
"A",
"B",
"C",
"D"
],
"text": [
"528.700",
"562.500",
"616.600",
"1119.400"
]
} | sciknow_d8e7553399b943b5 | 14,053 | 20,260,428 | sciknoweval_v2_hard_autogradable_512_2026_04_28 | Chemistry_L3 | Chemistry | L3 | mcq-4-choices | D | |
{
"default": "Given a question and four options, please select the right answer. Your answer should be \"A\", \"B\", \"C\" or \"D\". Please directly give the answer without any explanation."
} | What is the molar weight (g/mol) of the molecule with the the IUPAC name '(2S)-2-(furan-2-yl)-2-(hydroxyamino)ethanol'? | mcq-4-choices | Chemistry | {
"level": "L3",
"source": "PubChem",
"subtask": "i2w",
"task": "molar_weight_calculation"
} | B | {
"label": [
"A",
"B",
"C",
"D"
],
"text": [
"164.220",
"143.140",
"145.200",
"133.150"
]
} | sciknow_aa7ccc6563d3de41 | 14,069 | 20,260,428 | sciknoweval_v2_hard_autogradable_512_2026_04_28 | Chemistry_L3 | Chemistry | L3 | mcq-4-choices | B | |
{
"default": "Given a question and four options, please select the right answer. Your answer should be \"A\", \"B\", \"C\" or \"D\". Please directly give the answer without any explanation."
} | What is the molar weight (g/mol) of the molecule with the canonical SMILES representation 'C1=CC=C(C=C1)C=CCN(C2=C(C=C(C=N2)C(Cl)(Cl)Cl)N)C(C(=O)NC(C3=CC=CC=C3)C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)N)N=C(N)N)N=C(N)N)N=C(N)N)N=C(N)N)O'? | mcq-4-choices | Chemistry | {
"level": "L3",
"source": "PubChem",
"subtask": "s2w",
"task": "molar_weight_calculation"
} | D | {
"label": [
"A",
"B",
"C",
"D"
],
"text": [
"939.900",
"908.900",
"1010.200",
"1005.300"
]
} | sciknow_4b8cd9483514b14f | 14,081 | 20,260,428 | sciknoweval_v2_hard_autogradable_512_2026_04_28 | Chemistry_L3 | Chemistry | L3 | mcq-4-choices | D | |
{
"default": "Given a question and four options, please select the right answer. Your answer should be \"A\", \"B\", \"C\" or \"D\". Please directly give the answer without any explanation."
} | What is the molar weight (g/mol) of the molecule with the canonical SMILES representation 'CC(=O)NC(CCCNC(=N)N)C(=O)NC(CCCNC(=N)N)C(=O)NC(CC1=CNC2=CC=CC=C21)C(=O)NC3CSSCC(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C4CSSCC(C(=O)NC(C(=O)NC(C(=O)NCC(=O)NC(C(=O)N4)CC5=CC=C(C=C5)O)CCCCN)CC6=CC=C(C=C6)O)NC(=O)C(NC(=O)C(NC(=O)C(NC3=O)CC7=... | mcq-4-choices | Chemistry | {
"level": "L3",
"source": "PubChem",
"subtask": "s2w",
"task": "molar_weight_calculation"
} | C | {
"label": [
"A",
"B",
"C",
"D"
],
"text": [
"386.500",
"400.500",
"2529.000",
"810.900"
]
} | sciknow_07a961b00f9eeeca | 14,083 | 20,260,428 | sciknoweval_v2_hard_autogradable_512_2026_04_28 | Chemistry_L3 | Chemistry | L3 | mcq-4-choices | C | |
{
"default": "Given a question and four options, please select the right answer. Your answer should be \"A\", \"B\", \"C\" or \"D\". Please directly give the answer without any explanation."
} | What is the molar weight (g/mol) of the molecule with the canonical SMILES representation 'CC(=O)C1C=CC=CN1C(=O)CC#N'? | mcq-4-choices | Chemistry | {
"level": "L3",
"source": "PubChem",
"subtask": "s2w",
"task": "molar_weight_calculation"
} | D | {
"label": [
"A",
"B",
"C",
"D"
],
"text": [
"409.220",
"288.400",
"264.360",
"190.200"
]
} | sciknow_1f3b04ec6e75fd1a | 14,096 | 20,260,428 | sciknoweval_v2_hard_autogradable_512_2026_04_28 | Chemistry_L3 | Chemistry | L3 | mcq-4-choices | D | |
{
"default": "Given a question and four options, please select the right answer. Your answer should be \"A\", \"B\", \"C\" or \"D\". Please directly give the answer without any explanation."
} | What is the molar weight (g/mol) of the molecule with the canonical SMILES representation 'CC(=O)NC1C(CC(OC1C(C(CO)O)O)(C(=O)O)OCC2C(C(C(C(O2)OC3C(OC(C(C3O)NC(=O)C)OC4C(C(C(OC4OC5C(C(OC(C5O)OC6C(OC(C(C6O)NC(=O)C)OC7C(OC(C(C7O)NC(=O)C)O)CO)CO)COC8C(C(C(C(O8)CO)O)O)OC9C(C(C(C(O9)CO)OC1C(C(C(C(O1)CO)O)O)O)O)NC(=O)C)O)CO)O... | mcq-4-choices | Chemistry | {
"level": "L3",
"source": "PubChem",
"subtask": "s2w",
"task": "molar_weight_calculation"
} | B | {
"label": [
"A",
"B",
"C",
"D"
],
"text": [
"2547.800",
"2792.500",
"2912.700",
"2809.500"
]
} | sciknow_8fe8756e7d657422 | 14,194 | 20,260,428 | sciknoweval_v2_hard_autogradable_512_2026_04_28 | Chemistry_L3 | Chemistry | L3 | mcq-4-choices | B | |
{
"default": "Given a question and four options, please select the right answer. Your answer should be \"A\", \"B\", \"C\" or \"D\". Please directly give the answer without any explanation."
} | What is the molar weight (g/mol) of the molecule with the canonical SMILES representation 'CC(C(=O)NC(CCCCN)C(=O)NC(CCCNC(=N)N)C(=O)NC(CCC(=O)N)C(=O)NC(CCSC)C(=O)O)NC(=O)C(CCCNC(=N)N)NC(=O)C(CCCCN)NC(=O)C(CO)NC(=O)C(CO)NC(=O)C(CCC(=O)N)NC(=O)C(CCCCN)NC(=O)C(CC1=CC=CC=C1)NC(=O)C(CCC(=O)O)NC(=O)C(CCCCN)NC(=O)C(CC2=CC=CC=... | mcq-4-choices | Chemistry | {
"level": "L3",
"source": "PubChem",
"subtask": "s2w",
"task": "molar_weight_calculation"
} | A | {
"label": [
"A",
"B",
"C",
"D"
],
"text": [
"2270.700",
"2249.700",
"2185.500",
"2149.500"
]
} | sciknow_0cfba9334db86c2d | 14,214 | 20,260,428 | sciknoweval_v2_hard_autogradable_512_2026_04_28 | Chemistry_L3 | Chemistry | L3 | mcq-4-choices | A | |
{
"default": "Given a question and four options, please select the right answer. Your answer should be \"A\", \"B\", \"C\" or \"D\". Please directly give the answer without any explanation."
} | What is the correct logarithmic solubility value of the molecule "C=CC=C" in aqueous solutions? | mcq-4-choices | Chemistry | {
"level": "L3",
"source": "moleculenet",
"subtask": "ESOL_value_prediction",
"task": "molecular_property_prediction"
} | A | {
"label": [
"A",
"B",
"C",
"D"
],
"text": [
"-1.87",
"-2.943",
"-5.19",
"-0.89"
]
} | sciknow_01c38f26f0683740 | 14,371 | 20,260,428 | sciknoweval_v2_hard_autogradable_512_2026_04_28 | Chemistry_L3 | Chemistry | L3 | mcq-4-choices | A | |
{
"default": "Given a question and four options, please select the right answer. Your answer should be \"A\", \"B\", \"C\" or \"D\". Please directly give the answer without any explanation."
} | What is the correct octanol/water distribution coefficient logD under the circumstance of pH 7.4 for the molecule "O=C(COCc1ccncc1)N1CCC(c2ccc(Cl)cc2)CC1" ? | mcq-4-choices | Chemistry | {
"level": "L3",
"source": "moleculenet",
"subtask": "Lipophilicity_value_prediction",
"task": "molecular_property_prediction"
} | B | {
"label": [
"A",
"B",
"C",
"D"
],
"text": [
"0.21",
"2.74",
"2.21",
"3.42"
]
} | sciknow_433b75a0a2710991 | 14,564 | 20,260,428 | sciknoweval_v2_hard_autogradable_512_2026_04_28 | Chemistry_L3 | Chemistry | L3 | mcq-4-choices | B | |
{
"default": "Given a question and four options, please select the right answer. Your answer should be \"A\", \"B\", \"C\" or \"D\". Please directly give the answer without any explanation."
} | What is the correct octanol/water distribution coefficient logD under the circumstance of pH 7.4 for the molecule "Nc1ccc2c(c1)C(=O)c1ccccc1-2" ? | mcq-4-choices | Chemistry | {
"level": "L3",
"source": "moleculenet",
"subtask": "Lipophilicity_value_prediction",
"task": "molecular_property_prediction"
} | D | {
"label": [
"A",
"B",
"C",
"D"
],
"text": [
"-0.7",
"2.21",
"3.3",
"2.9"
]
} | sciknow_72fdca3c9bd7b3a7 | 14,570 | 20,260,428 | sciknoweval_v2_hard_autogradable_512_2026_04_28 | Chemistry_L3 | Chemistry | L3 | mcq-4-choices | D | |
{
"default": "Given a question and four options, please select the right answer. Your answer should be \"A\", \"B\", \"C\" or \"D\". Please directly give the answer without any explanation."
} | What is the correct octanol/water distribution coefficient logD under the circumstance of pH 7.4 for the molecule "CC(C)Cn1c(=O)n(C)c(=O)c2c(C(=O)N3CC[C@@H](O)C3)c(Cc3ccccc3C(F)(F)F)sc21" ? | mcq-4-choices | Chemistry | {
"level": "L3",
"source": "moleculenet",
"subtask": "Lipophilicity_value_prediction",
"task": "molecular_property_prediction"
} | C | {
"label": [
"A",
"B",
"C",
"D"
],
"text": [
"0.6",
"3.2",
"2.74",
"2.06"
]
} | sciknow_87a4868ecc80009c | 14,599 | 20,260,428 | sciknoweval_v2_hard_autogradable_512_2026_04_28 | Chemistry_L3 | Chemistry | L3 | mcq-4-choices | C | |
{
"default": "Given a question and four options, please select the right answer. Your answer should be \"A\", \"B\", \"C\" or \"D\". Please directly give the answer without any explanation."
} | What is the correct octanol/water distribution coefficient logD under the circumstance of pH 7.4 for the molecule "O=C1NC(=O)/C(=C/c2ccc3c(c2)OC(F)(F)O3)S1" ? | mcq-4-choices | Chemistry | {
"level": "L3",
"source": "moleculenet",
"subtask": "Lipophilicity_value_prediction",
"task": "molecular_property_prediction"
} | D | {
"label": [
"A",
"B",
"C",
"D"
],
"text": [
"1.92",
"0.64",
"3.28",
"2.8"
]
} | sciknow_f4c47d18b9bc4faf | 14,762 | 20,260,428 | sciknoweval_v2_hard_autogradable_512_2026_04_28 | Chemistry_L3 | Chemistry | L3 | mcq-4-choices | D | |
{
"default": "Given a question and four options, please select the right answer. Your answer should be \"A\", \"B\", \"C\" or \"D\". Please directly give the answer without any explanation."
} | What is the correct octanol/water distribution coefficient logD under the circumstance of pH 7.4 for the molecule "CN(C)C(=O)CC(NC(=O)C1(N)CCN(c2ncnc3[nH]ccc23)CC1)c1ccc(Cl)cc1" ? | mcq-4-choices | Chemistry | {
"level": "L3",
"source": "moleculenet",
"subtask": "Lipophilicity_value_prediction",
"task": "molecular_property_prediction"
} | B | {
"label": [
"A",
"B",
"C",
"D"
],
"text": [
"3.2",
"2.4",
"1.66",
"0.7"
]
} | sciknow_716d57d9d042b106 | 14,822 | 20,260,428 | sciknoweval_v2_hard_autogradable_512_2026_04_28 | Chemistry_L3 | Chemistry | L3 | mcq-4-choices | B | |
{
"default": "Given a question and four options, please select the right answer. Your answer should be \"A\", \"B\", \"C\" or \"D\". Please directly give the answer without any explanation."
} | What is the correct octanol/water distribution coefficient logD under the circumstance of pH 7.4 for the molecule "Cc1sc(N2CCN(C)CC2)nc1CCOc1ccc(C[C@H](Nc2ccccc2C(=O)c2ccccc2)C(=O)O)cc1" ? | mcq-4-choices | Chemistry | {
"level": "L3",
"source": "moleculenet",
"subtask": "Lipophilicity_value_prediction",
"task": "molecular_property_prediction"
} | C | {
"label": [
"A",
"B",
"C",
"D"
],
"text": [
"0.5",
"2.0",
"2.58",
"3.1"
]
} | sciknow_2e312f0ca79b52ce | 14,840 | 20,260,428 | sciknoweval_v2_hard_autogradable_512_2026_04_28 | Chemistry_L3 | Chemistry | L3 | mcq-4-choices | C | |
{
"default": "Given a question and four options, please select the right answer. Your answer should be \"A\", \"B\", \"C\" or \"D\". Please directly give the answer without any explanation."
} | What is the correct octanol/water distribution coefficient logD under the circumstance of pH 7.4 for the molecule "CN(C)CCC=C1c2ccccc2C=Cc2ccccc21" ? | mcq-4-choices | Chemistry | {
"level": "L3",
"source": "moleculenet",
"subtask": "Lipophilicity_value_prediction",
"task": "molecular_property_prediction"
} | D | {
"label": [
"A",
"B",
"C",
"D"
],
"text": [
"3.4",
"0.29",
"1.8",
"2.83"
]
} | sciknow_9c6db02219bd1a00 | 14,864 | 20,260,428 | sciknoweval_v2_hard_autogradable_512_2026_04_28 | Chemistry_L3 | Chemistry | L3 | mcq-4-choices | D | |
{
"default": "Given a question and four options, please select the right answer. Your answer should be \"A\", \"B\", \"C\" or \"D\". Please directly give the answer without any explanation."
} | How many atoms are there in the molecule with the the IUPAC name '(2S)-2-aminopentanoate'? | mcq-4-choices | Chemistry | {
"level": "L3",
"source": "PubChem",
"subtask": "i2atoms",
"task": "molecule_structure_prediction"
} | B | {
"label": [
"A",
"B",
"C",
"D"
],
"text": [
"63",
"18",
"58",
"80"
]
} | sciknow_7f10102fc77f8b9f | 13,471 | 20,260,428 | sciknoweval_v2_hard_autogradable_512_2026_04_28 | Chemistry_L3 | Chemistry | L3 | mcq-4-choices | B | |
{
"default": "Given a question and four options, please select the right answer. Your answer should be \"A\", \"B\", \"C\" or \"D\". Please directly give the answer without any explanation."
} | How many atoms are there in the molecule with the the IUPAC name '(2S)-N-benzyl-1-[(2S)-1-[(2S)-2-[[(2S)-2-[[(2S)-2-(dimethylamino)-3-methylbutanoyl]amino]-3-methylbutanoyl]-methylamino]-3-methylbutanoyl]pyrrolidine-2-carbonyl]pyrrolidine-2-carboxamide'? | mcq-4-choices | Chemistry | {
"level": "L3",
"source": "PubChem",
"subtask": "i2atoms",
"task": "molecule_structure_prediction"
} | C | {
"label": [
"A",
"B",
"C",
"D"
],
"text": [
"96",
"88",
"204",
"80"
]
} | sciknow_34979843008a8d11 | 13,528 | 20,260,428 | sciknoweval_v2_hard_autogradable_512_2026_04_28 | Chemistry_L3 | Chemistry | L3 | mcq-4-choices | C | |
{
"default": "Given a question and four options, please select the right answer. Your answer should be \"A\", \"B\", \"C\" or \"D\". Please directly give the answer without any explanation."
} | How many rotatable bonds are there in the molecule with the IUPAC name '(2S)-2-amino-5-(diaminomethylideneamino)pentanoic acid;(2S)-2-amino-3-(4-hydroxyphenyl)propanoic acid;(2S)-2-amino-4-methylpentanoic acid;(2S)-2-amino-3-phenylpropanoic acid;(2S)-2,6-diaminohexanoic acid'? | mcq-4-choices | Chemistry | {
"level": "L3",
"source": "PubChem",
"subtask": "i2rotbonds",
"task": "molecule_structure_prediction"
} | C | {
"label": [
"A",
"B",
"C",
"D"
],
"text": [
"12",
"14",
"29",
"13"
]
} | sciknow_eb1c40101cf287d7 | 13,552 | 20,260,428 | sciknoweval_v2_hard_autogradable_512_2026_04_28 | Chemistry_L3 | Chemistry | L3 | mcq-4-choices | C | |
{
"default": "Given a question and four options, please select the right answer. Your answer should be \"A\", \"B\", \"C\" or \"D\". Please directly give the answer without any explanation."
} | How many heavy atoms are there in the molecule with the IUPAC name '(2S)-3-(4-hydroxyphenyl)-2-[(2-methylpropan-2-yl)oxycarbonylamino]propanoic acid;methyl (2S)-2-amino-4-methylselanylbutanoate;methyl (2S)-2-[[(2S)-3-(4-hydroxyphenyl)-2-[(2-methylpropan-2-yl)oxycarbonylamino]propanoyl]amino]-4-methylselanylbutanoate;hy... | mcq-4-choices | Chemistry | {
"level": "L3",
"source": "PubChem",
"subtask": "i2heavyatoms",
"task": "molecule_structure_prediction"
} | A | {
"label": [
"A",
"B",
"C",
"D"
],
"text": [
"60",
"45",
"47",
"43"
]
} | sciknow_931c3d6ef4274254 | 13,716 | 20,260,428 | sciknoweval_v2_hard_autogradable_512_2026_04_28 | Chemistry_L3 | Chemistry | L3 | mcq-4-choices | A | |
{
"default": "Given a question and four options, please select the right answer. Your answer should be \"A\", \"B\", \"C\" or \"D\". Please directly give the answer without any explanation."
} | How many hydrogen bond acceptors are there in the molecule with the canonical SMILES representation 'CC(=O)NC(CCCCNC(=O)C1=C2C=CC=CC2=NC3=CC=CC=C31)C(=O)NCC(=O)NC(CCCNC(=N)N)C(=O)NC(CN4C=CC(=O)NC4=O)C(=O)N(C)CC(=O)NC(CN5C(=O)C6=CC=CC=C6NC5=O)C(=O)NC(CN7C(=O)C8=CC=CC=C8NC7=O)C(=O)NC(CN9C(=O)C1=CC=CC=C1NC9=O)C(=O)NC(CCCN... | mcq-4-choices | Chemistry | {
"level": "L3",
"source": "PubChem",
"subtask": "s2hbondacc",
"task": "molecule_structure_prediction"
} | C | {
"label": [
"A",
"B",
"C",
"D"
],
"text": [
"32",
"28",
"22",
"27"
]
} | sciknow_f21be1084ba61e6c | 13,717 | 20,260,428 | sciknoweval_v2_hard_autogradable_512_2026_04_28 | Chemistry_L3 | Chemistry | L3 | mcq-4-choices | C | |
{
"default": "Given a question and four options, please select the right answer. Your answer should be \"A\", \"B\", \"C\" or \"D\". Please directly give the answer without any explanation."
} | How many heavy atoms are there in the molecule with the IUPAC name '(3S)-N-[(2S)-1-[(2-amino-2-oxoethyl)amino]-4-methyl-1-oxopentan-2-yl]-2-[(4S,7S,13S,16S)-7-(2-amino-2-oxoethyl)-10-(3-amino-3-oxopropyl)-13-[(2S)-butan-2-yl]-16-[(4-hydroxyphenyl)methyl]-6,9,12,15,18-pentaoxo-1-thia-5,8,11,14,17-pentazacycloicosane-4-c... | mcq-4-choices | Chemistry | {
"level": "L3",
"source": "PubChem",
"subtask": "i2heavyatoms",
"task": "molecule_structure_prediction"
} | D | {
"label": [
"A",
"B",
"C",
"D"
],
"text": [
"72",
"73",
"71",
"70"
]
} | sciknow_acf4d579b100dc8b | 13,729 | 20,260,428 | sciknoweval_v2_hard_autogradable_512_2026_04_28 | Chemistry_L3 | Chemistry | L3 | mcq-4-choices | D | |
{
"default": "Given a question and four options, please select the right answer. Your answer should be \"A\", \"B\", \"C\" or \"D\". Please directly give the answer without any explanation."
} | A chemical reaction involves the following reactants and reagents (in SMILES notation) which are separated by ".":
C1CCOC1.Cc1ccc(S(=O)(=O)Cl)cc1.O=C(Nc1cnc2[nH]cc(Br)c2c1)OCc1ccccc1.[H-].[Na+]
Which of the following SMILES notations is the correct representation of the resultant product? | mcq-4-choices | Chemistry | {
"level": "L3",
"source": "uspto_mixed",
"subtask": "reaction_pred_mcq",
"task": "reaction_prediction"
} | D | {
"label": [
"A",
"B",
"C",
"D"
],
"text": [
"Cc1ccc(S(=O)(=O)Nc2ccc3[nH]c(=O)c4[nH]ccc4c3c2)cc1",
"Cc1ccc(S(=O)(=O)n2c(C)nc3c(O)cc(C(=O)N(C)C)cc32)cc1",
"Cc1ccc(S(=O)(=O)n2ccc3c(C=O)cccc32)cc1",
"Cc1ccc(S(=O)(=O)n2cc(Br)c3cc(NC(=O)OCc4ccccc4)cnc32)cc1"
]
} | sciknow_4d0d85e4c884ca20 | 15,236 | 20,260,428 | sciknoweval_v2_hard_autogradable_512_2026_04_28 | Chemistry_L3 | Chemistry | L3 | mcq-4-choices | D | |
{
"default": "Given a question and four options, please select the right answer. Your answer should be \"A\", \"B\", \"C\" or \"D\". Please directly give the answer without any explanation."
} | Consider the reactants and reagents listed and separated by a ".":
CN(C)C1CCN(c2nc3ccc(N)cc3s2)C1.CN(C)C=O.ClCCl.O=C(Cl)C(=O)Cl.O=C(O)C=Cc1cccc(Cl)c1
From the options below, which SMILES notation correctly describes the resultant product? | mcq-4-choices | Chemistry | {
"level": "L3",
"source": "uspto_mixed",
"subtask": "reaction_pred_mcq",
"task": "reaction_prediction"
} | A | {
"label": [
"A",
"B",
"C",
"D"
],
"text": [
"CN(C)C1CCN(c2nc3ccc(NC(=O)C=Cc4cccc(Cl)c4)cc3s2)C1",
"CN1CCC(c2c[nH]c3ccc(OS(=O)(=O)c4ccc(I)cc4)cc23)CC1",
"N#CC1CCN(c2ccc3c(NC(=O)CC4CCCCC4)c(Cl)ccc3n2)C1",
"CN(C)C1CCc2oc3ccc(NC(=O)c4ccc(F)cc4)cc3c2C1"
]
} | sciknow_9b82b30a22eb885a | 15,290 | 20,260,428 | sciknoweval_v2_hard_autogradable_512_2026_04_28 | Chemistry_L3 | Chemistry | L3 | mcq-4-choices | A | |
{
"default": "Given a question and four options, please select the right answer. Your answer should be \"A\", \"B\", \"C\" or \"D\". Please directly give the answer without any explanation."
} | For the chemical reaction with the reactants and reagents given (separated by "."):
CC(=O)Nc1ccc2nc(-c3ccc(C4CCCCC4)cc3)cc(O)c2c1.CCCCCC.COS(=O)(=O)OC.Cc1ccccc1
Which SMILES notation corresponds to the resultant product? | mcq-4-choices | Chemistry | {
"level": "L3",
"source": "uspto_mixed",
"subtask": "reaction_pred_mcq",
"task": "reaction_prediction"
} | B | {
"label": [
"A",
"B",
"C",
"D"
],
"text": [
"Cc1cc(CNCCC(C)C)ccc1-c1ccc(C(N)=O)cc1C",
"COc1cc(-c2ccc(C3CCCCC3)cc2)nc2ccc(NC(C)=O)cc12",
"COc1ccc(N2CCOCC2)c2sc(C(N)=S)nc12",
"COc1cc(-c2cn(C3CCCC3)c3ncnc(N)c23)ccc1NC(=O)Cc1cccs1"
]
} | sciknow_43d5d08374c1e82e | 15,306 | 20,260,428 | sciknoweval_v2_hard_autogradable_512_2026_04_28 | Chemistry_L3 | Chemistry | L3 | mcq-4-choices | B | |
{
"default": "Given a question and four options, please select the right answer. Your answer should be \"A\", \"B\", \"C\" or \"D\". Please directly give the answer without any explanation."
} | With the provided reactants and reagents in the reaction which are separated by ".":
CCN1CCCC(CN2CCNCC2)C1.CCN=C=NCCCN(C)C.CCO.CN(C)C=O.Cl.N#CN.S=C=Nc1ccc(Cl)c(Cl)c1.[Na]
Which of the following options correctly depicts the product in SMILES notation? | mcq-4-choices | Chemistry | {
"level": "L3",
"source": "uspto_mixed",
"subtask": "reaction_pred_mcq",
"task": "reaction_prediction"
} | C | {
"label": [
"A",
"B",
"C",
"D"
],
"text": [
"CN1CCC(NC(=O)c2ccc(N)c(F)c2)CC1",
"CN1CCCC(CN2CCN(C(=S)Nc3ccc(Cl)c(Cl)c3)CC2)C1",
"CCN1CCCC(CN2CCN(C(=NC#N)Nc3ccc(Cl)c(Cl)c3)CC2)C1",
"CCCC1CCC(CCC2CCC(c3cccc(F)c3)CC2)CC1"
]
} | sciknow_24d4f75a6549a33c | 15,326 | 20,260,428 | sciknoweval_v2_hard_autogradable_512_2026_04_28 | Chemistry_L3 | Chemistry | L3 | mcq-4-choices | C | |
{
"default": "Given a question and four options, please select the right answer. Your answer should be \"A\", \"B\", \"C\" or \"D\". Please directly give the answer without any explanation."
} | Here is a chemical reaction reactants and reagents which are separated by ".":
O=C(Cc1ccc(F)cc1)Nc1nn2cccnc2c1Br.OB(O)c1ccc(Cl)nc1
Please choose the correct SMILES notation for the product: | mcq-4-choices | Chemistry | {
"level": "L3",
"source": "uspto_mixed",
"subtask": "reaction_pred_mcq",
"task": "reaction_prediction"
} | B | {
"label": [
"A",
"B",
"C",
"D"
],
"text": [
"O=C(O)C(=Cc1ccncc1)c1ccc(Cl)cc1",
"O=C(Cc1ccc(F)cc1)Nc1nn2cccnc2c1-c1ccc(Cl)nc1",
"ON=C(c1cccc(F)c1)c1cccc(F)c1",
"CN(C)c1ccccc1NC(=O)c1cnccc1Oc1cc(Cl)ccc1Cl"
]
} | sciknow_f6b6637ca5f46db8 | 15,342 | 20,260,428 | sciknoweval_v2_hard_autogradable_512_2026_04_28 | Chemistry_L3 | Chemistry | L3 | mcq-4-choices | B | |
{
"default": "Given a question and four options, please select the right answer. Your answer should be \"A\", \"B\", \"C\" or \"D\". Please directly give the answer without any explanation."
} | Here is a chemical reaction reactants and reagents which are separated by ".":
COC(F)(c1ccc2c(c1)c(NCC(=O)NC1CNC1)nn2C)C(F)(F)F.COc1ccc(C2(O)CCC(=O)CC2)cn1
Please choose the correct SMILES notation for the product: | mcq-4-choices | Chemistry | {
"level": "L3",
"source": "uspto_mixed",
"subtask": "reaction_pred_mcq",
"task": "reaction_prediction"
} | B | {
"label": [
"A",
"B",
"C",
"D"
],
"text": [
"COCCn1cc(C(=O)N2CCC(c3cc(CNC(=O)C(F)(F)F)ccc3F)CC2)c2c(OC(F)(F)F)ccc(F)c21",
"COc1ccc(C2(O)CCC(N3CC(NC(=O)CNc4nn(C)c5ccc(C(F)(OC)C(F)(F)F)cc45)C3)CC2)cn1",
"COc1ccc(COC(=O)C(CC(C)C)N(C(=O)OCC(Cl)(Cl)Cl)c2nn(C(=O)OC(C)(C)C)cc2Br)cc1",
"C... | sciknow_c8fbbca9139fd4ca | 15,391 | 20,260,428 | sciknoweval_v2_hard_autogradable_512_2026_04_28 | Chemistry_L3 | Chemistry | L3 | mcq-4-choices | B |
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