id stringlengths 4 9 | paragraph stringlengths 107 11.4k | index int64 0 227 |
|---|---|---|
55209977 | Mass-Based Investigation of Particle Volatility Mass-based particle volatility was investigated with the TGA to evaluate the mass fraction of volatile and nonvolatile substances in the particulate samples collected on filter papers installed inside the MOUDI.The brake specific emissions of volatile and non-volatile sub... | 5 |
55209977 | Particle Number Concentration, Size Distribution and Volatility Number-based particle concentration, size distribution and volatility were investigated using the SMPS and the TD, with the TD set to 275°C.The particles measured with the SMPS alone contain both non-volatile and volatile substances while those measured wi... | 6 |
55209977 | Particle Number Concentration and Volatility in Different Size Groups Nanoparticles (< 50 nm) are more hazardous to human health (Peters et al., 1997;Somers et al., 2004).Thus, the particles are classified into three groups: < 50, 50-100 and > 100 nm, for further analysis.The effect of fuel type and engine load on the ... | 7 |
54729029 | In this paper the mathematical model describing the falling thin liquid film on a vertical wall is considered taking into account heat and mass transfer at the interface in the regime of periodic rolling waves. The families of exact and numerical generalized solutions, where periodic traveling waves conjugate through t... | 1 |
54729029 | Problem statement Heat transfer at condensation of immobile saturated vapor on a vertical surface was firstly considered in [1] for the case of the laminar flow of a condensate film.Later, theoretical and experimental studies of the film flows, including those with consideration of heat and mass transfer on the free s... | 2 |
54729029 | Periodic solution of equation of the rolling wave at phase transition The hyperbolic equation ( 2) admits exact solution 2 ( , , ) 2 describes a change in initial film thickness (0, ) condensation, the film thickness increases, and at 0 E , i.e., at evaporation, the film thickness decreases.We will derive the exact sol... | 3 |
98253702 | A síntese de uma série de álcoois secundários derivados da (R)-carvona, assim como o curso estereoquímico da esterificação destes derivados com (±)-ibuprofeno é apresentada. O composto comercial racêmico foi transformado nos respectivos ésteres diastereoisoméricos através do acoplamento mediado por DCC/DMAP, fornecendo... | 1 |
98253702 | Introduction During the past two decades, the preparation of optically active drugs has received considerable attention both, from academics and industry.The reasons behind this interest are threefold, including the medical benefit from using a single chemical entity, the changing pharmaceutical regulations, which now... | 2 |
98253702 | Results and Discussion Three series of secondary alcohols were prepared.In the first one, (R)-carvone was submitted to a conjugate addition reaction with thiophenol under thermodynamic conditions, 20 furnishing thioethers (7a-c, Scheme 1) in 4, 34 and 16% yield, respectively.On the other hand, reaction with PhSH and 2-... | 3 |
98253702 | Me The third group of chiral alcohols was obtained after subjecting (R)-carvone to conjugate addition reactions with aryl and 1-naphthyl Grignard reagents in the presence of copper(I) iodide 31 to which TMSCl was added in order to ensure efficient transformations. 32ese gave the corresponding silyl enol ether intermedi... | 4 |
98253702 | Experimental Melting points were taken on an Ernst Leitz Wetzlar model 350 hot-stage microscope and are reported uncorrected.Specific rotation data were obtained with a Jasco DIP 1000 photopolarimeter, fitted with 1 dm cells.FT-IR spectra were determined employing a Shimadzu Prestige 21 spectrophotometer as solid dispe... | 5 |
98253702 | S , 3 R , 5 R ) -5 -I s o p r o p e n y l --m e t h y l -3phenylcyclohexanone 19a: CuI (500 mg, 2.64 mmol) was added to a stirred 1.18M THF solution of PhMgBr (8 mL, 5.28 mmol), cooled to 0 ºC.After stirring 15 min, a solution of (R)-carvone (209 mg, 1.39 mmol) and TMSCl (772 mg, 7.1 mmol) in THF (2 mL) was introduced ... | 6 |
98253702 | Table 2 . Esterification a Deduced by comparison with esters prepared with pure (S)-ibuprofen. 1 H enone 16c: 18% PCC on Al 2 O 3 (1.09g, 0.91 mmol) was added portionwise to a solution of alcohol 15c (98 mg, 0.38 mmol) in anhydrous CH 2 Cl 2 (15 mL), and the resulting suspension was stirred 1 day at room temperature.Th... | 8 |
225649150 | Chalcone is one of the phenolic group secondary metabolic with numerous biological activities. Many studies have shown that chalcone derivatives compound has anti-cancer, anti-inflammatory, antimalarial, and antibacterial activities. The purpose of this research was to study the prediction potency unsaturated carbonyl ... | 1 |
225649150 | Introduction Cancer is a disease caused by abnormal and uncontrolled cell growth (Anwar et al., 2018). In its development, cancer cells can spread to other parts of the body and end in death. In general, the cause of cancer cannot be ascertained. Various factors both genetic and environmental factors (Shanmugam et al.... | 2 |
225649150 | Discussion Chalcone compound, 2,4-dihydroxide-4'-methoxychalcone was prepared by the Claisen-Schmidt according to Scheme 1. To obtain chalcone in good yield, the residues were treated with 10 % in methanol. The synthesis compound was evaluated for its activity as anti-cancer by showed IC50 value may be influenced to su... | 3 |
58914429 | A cathodic stripping voltammetric method for determination of Ti(IV) in water samples containing high concentrations of surfactants is described. The linear calibration plot for Ti(IV) was achieved in the simultaneous presence of 5 mg L anionic, 1 mg L cationic and 2 mg L nonionic surfactants for an accumulation time o... | 1 |
58914429 | Introduction The excellent properties possessed by titanium make it a highly useful material.Titanium alloys have been increasingly widely used in aviation, aerospace, shipbuilding and other industrial departments whereas the main use of TiO 2 is as a white powder pigment used in products such as paints, coatings, pla... | 2 |
58914429 | E3S Web of Conferences The measurements were made using an EA-9 electrochemical analyzer and a controlled growth static mercury drop electrode in the HMDE mode, both made by MTM-ANKO Cracow, Poland.A three electrode system consisting of an Hg drop working electrode (drop surface area 1.4 mm 2 ), a Pt auxiliary electrod... | 3 |
58914429 | The elimination of influence of nonionic surface active compounds Triton X-100 is a high-purity, water-soluble, liquid nonionic surfactant that has come to be recognized as a performance standard among similar products.Triton X-100 is widely used in numerous commercial and industrial products as a substrate for deterge... | 4 |
58914429 | The elimination of influence of anionic surface active compounds Anionic synthetic surfactant sodium dodecylsulfate (SDS) was selected for this work due to its high solubility in water and first of all because it is a well-established commercial anionic synthetic surfactant.SDS is commonly used as an ingredient in hous... | 5 |
58914429 | Environmental samples analysis Four fresh environmental water samples, such as river water (Bystrzyca, Czerniejowka), stagnant water (Lake Zemborzyce) and rain water were collected from eastern areas of Poland and Ti(IV) determination by the proposed procedure was performed.No Ti(IV) was detected in the samples in conc... | 6 |
195401952 | Many of the medicaments used historically in root canal treatment have been shown to be cytotoxic [1]. Toxic devitalising agents such as arsenic trioxide (As2O3), a water-soluble compound, forming arsenious acid (H3AsO4) and paraformaldehyde were commonly used in the past to devitalise inflamed pulps when effective ana... | 1 |
195401952 | Introduction Many of the medicaments used historically in root canal treatment have been shown to be cytotoxic [1]. Toxic devitalising agents such as arsenic trioxide (As2O3), a water-soluble compound, forming arsenious acid (H3AsO4) and paraformaldehyde were commonly used in the past to devitalise inflamed pulps when... | 2 |
195401952 | Advances in Dentistry & Oral Health A 20-year-old female presented to her dentist complaining of pain in the maxillary right quadrant. The practitioner elected to devitalize tooth 16, which had shown signs of pulpitis, with a paraformaldehyde-containing paste since local anaesthesia had been ineffective. Shortly after ... | 3 |
195401952 | Case 2 A 35-year-old female with a history of severe pain in the left mandibular molar region was referred for assessment. The patient reported symptoms of irreversible pulpitis around from tooth 36 ( Figure 4A & 4B). His general dental practitioner was unable to obtain adequate anaesthesia to extirpate the pulp from t... | 4 |
195401952 | Discussion The primary cause of pulpal pathosis is bacterial infection. Without the presence of bacteria in the root canal system, periradicular inflammation will not develop or persist [19]. Consequently, the purpose of root canal treatment is the elimination of bacteria and their substrates from the pulp canal system... | 5 |
164474492 | Amlodipine is the best-prescribed medication for cardiovascular disease major risk factor for hypertension and atorvastatin well known for diabetic. First discussed low cost ultraviolet-visible technique for the determination and quantitation of drugs in pharmaceuticals and biological fluids. Chromatographic techniques... | 1 |
164474492 | INTRODUCTION Amlodipine besylate ( fig. 1a) is scientifically known as (RS)-3-ethyl-5-methyl-2-(2-aminoethoxymethyl)-4-(2-chlorophenyl)-1,4-dihydro -6-methyl-3,5-pyridinedicarboxylate benzene sulfonate. It was first introduced and prescribed for coronary artery disease. It was also helpful for angina and peripheral ar... | 2 |
164474492 | UV-visible spectrophotometer Spectroscopic methods are mostly used for the determination of drugs in bulk as well as with pharmaceutical formulations. Ultraviolet (UV) and visible spectrophotometry are important and common techniques for the quantitative analysis of drugs. Because these are low-cost techniques, simple ... | 3 |
164474492 | High performance liquid chromatography High-performance liquid chromatography (HPLC) technique is more accurate and based on the properties of the analyte with the existing mobile phase and stationary phase. Depending on the stationary and mobile phase, different types of chromatography techniques are developed. Recent... | 4 |
164474492 | Ultra pressure liquid chromatography Thin-layer chromatography (TLC) is a simple separation technique typically for the mixture of nonvolatile compounds. The adsorbent material, specifically cellulose, silica gel, aluminum oxide is covered on plastic or glass sheet, known as the stationary phase. Aleppo bentonite with ... | 6 |
164474492 | 248 Bulk drug and tablets [83] High-performance thin layer chromatography High-performance thin layer chromatography (HPTLC) is an accelerated separation technique and flexible enough to determine the drug sample. The advantages associated with HPTLC are a short analysis time for the complex sample without pretreatment... | 7 |
164474492 | Capillary electrophoresis Capillary electrophoresis (CE) is based on charge and size under electric field separate molecules. The capillary tube is made of glass loaded with an electrolyte solution. Electrophoretic mobility is an important parameter for the separation, chemical constituents as well as solvent viscosity... | 8 |
164474492 | DISCUSSION The UV-visible spectrophotometer does not require any pH adjustment and very close to the pharmacopeia method for both drugs. Recently HPTLC can be applied as an alternative option for traditional TLC method. It is easy to handle with software, which is not possible with TLC. HPTLC enhanced the capability to... | 9 |
43531704 | In this work, a series of CeO2-SiO2 (30 wt % of ceria)-based catalysts was prepared by the wetness impregnation method and tested for ESR (ethanol steam reforming) at 450–500 ◦C, atmospheric pressure and a water/ethanol ratio increasing from 4 to 6 (the ethanol concentration being fixed to 10 vol %); after every test, ... | 1 |
43531704 | Introduction In order to encourage an economy based on clean energy, the demand for hydrogen fuel cells is expected to grow rapidly in the near future [1].Hydrogen is a valid alternative to conventional fuels due to its ability to burn without emitting environmental pollutants, as well as its high energy content per u... | 2 |
43531704 | Catalyst Preparation and Characterization Five CeO 2 -SiO 2 based catalysts (Pt-Ni, Rh-Pt-Ni, Rh-Ni, Pt-Ni-K, Pt-Ni-Cs) were prepared by sequential wetness impregnation.More details about the preparation method are reported in [32].CeO 2 content in the catalyst was previously optimized and fixed to 30 wt %; Ni and nobl... | 3 |
43531704 | Catalyst Testing An amount of the calcined sample (4.5 g) was pressed, sieved into a 45-80 mesh, and loaded in a stainless steel tubular reactor (Officina Elettromeccanica Mormile, Casavatore, Italy) having an annular configuration (internal diameter = 15 mm, external diameter = 17 mm).The sample was treated in an H 2 ... | 4 |
43531704 | Ethanol Steam Reforming Tests: Effect of Catalytic Formulation The stability tests carried out at 450 • C and f.r.= 3 were performed for different times, selected in order to reach 500 mbar of pressure drops through the bed and guarantee almost the same mass of carbon deposited.The results shown in Table 3 revealed a v... | 6 |
43531704 | Ethanol Steam Reforming Tests: Effect of Operative Conditions The impact of different amount of steam and the influence of reaction temperatures on the Pt-Ni/CeO2-SiO2 catalyst performances during ethanol steam reforming at WHSV = 4.1 h −1 was also investigated.C2H5OH conversion was not affected by water partial pressu... | 7 |
43531704 | Ethanol Steam Reforming Tests: Effect of Operative Conditions The impact of different amount of steam and the influence of reaction temperatures on the Pt-Ni/CeO 2 -SiO 2 catalyst performances during ethanol steam reforming at WHSV = 4.1 h −1 was also investigated.C 2 H 5 OH conversion was not affected by water partial... | 8 |
42552672 | Introduction 2][3][4] The reaction of the broad spectrum insecticide fenitrothion, 1, with a variety of oxygen-based nucleophiles has engaged our recent attention. 3,4In aqueous solution, 1 reacts with a variety of oxygen nucleophiles, to include some alpha-nucleophiles and a series of structurally related phenoxides ... | 2 |
42552672 | Results and Discussion Reaction pathways 3-Methyl-4-nitrophenoxide, the product of nucleophilic attack at the P center of 1, absorbs at 398 nm.Quantitative thiophosphoryl group transfer should yield experimental absorbances at the end of the reaction which are identical to the calculated values for this nucleofuge, wit... | 3 |
42552672 | Base catalysis and the mechanism of the S N Ar reaction The gross mechanism for S N Ar reactions is given in Scheme 2, in which either the formation of the Meisenheimer-type intermediate, PH, or its decomposition to products could be rate determining.According to this mechanism, the observed second-order rate constant,... | 4 |
42552672 | Site preferences in the reaction of 1 with oxygen and nitrogen nucleophiles 8][29][30][31][32][33][34][35][36] Khan and Kirby 37 have published on the multiple structure-reactivity correlations for reactions of phosphate triesters with a variety of nucleophiles.What is clear from the literature is that reactivities are... | 5 |
42552672 | Experimental Section General Procedures.Materials.Reagents were commercial products which were either used as received or purified according to literature procedures.Stock solutions of the substrate were prepared under nitrogen and stored in volumetric flasks which were sealed with rubber septa, protected from light by... | 6 |
42552672 | Determination of reaction products Reaction was initiated by injecting the required amount of a stock solution (9.54 x 10 -3 M) of 1 into a capped glass vial containing the appropriate concentration of the relevant amine at room temperature.In all cases, the amine concentration was in large excess of the substrate.The ... | 7 |
52024679 | In this paper a simple, precise and rapid high performance liquid chromatography method with UV detection has been developed for the determination of saxagliptin and metformin in bulk. An Agilent, Zorbax CN (250 × 4.6 mm I.D., 5 µm) column was used with a mobile phase mixture of methanol-50 mM phosphate buffer (pH 2.7)... | 1 |
52024679 | Introduction Saxagliptin (SAX) (1S,3S,5S)-2-[(2S)-2-amino-2-(3-hydroxy-1adamantyl)acetyl]-2 azabicyclo[3.1.0]hexane-3-carbonitrile) ( Figure 1), with C 18 H 25 N 3 O 2 chemical formula and 315.41 g/mol molecular weight, is an orally active, potent and selective inhibitor of dipeptidyl peptidase-IV (DPP-4) for the tre... | 2 |
52024679 | Experimental Chemicals Saxagliptin was purchased from Richem International Co., Ltd. (Shanghai, China). Metformin was kindly supplied by Abdi Ibrahim Ilac (Istanbul, Turkey). Commercially available Onglyza ® tablets were purchased from local drug store. Sodium dihydrogen phosphate (NaH 2 PO 4 ), analytical grade ortho-... | 3 |
52024679 | Instrumentation and analytical conditions A Shimadzu (Kyoto, Japan) LC 20A liquid chromatograph, consisting of a model LC 20 AT solvent delivery system, a DGU-20A5 degasser and a SIL-20AC auto sampler (set at ambient temperature) and a diode array detector SPD-M20A was used. During method development different waveleng... | 4 |
52024679 | Preparation of solutions Stock solutions were prepared by dissolving SAX and MET in acetonitrile and water respectively to give a concentration of 1 mg ml -1 . Standard solutions with a concentration of 100 µg ml -1 were obtained by diluting of the stock solutions with mobile phase mixture (10% methanol, 90% buffer). T... | 5 |
52024679 | Acidic, neutral and basic hydrolysis: A solution of SAX 10 mg ml -1 concentration was prepared in acetonitrile, 1 ml of this solution was transferred to three different 10 mL volumetric flasks and diluted up to volume with water, 0.1 HCl and 0.1 NaOH solutions to give a concentration of 1 mg ml -1 . Samples of 0.25 mL ... | 7 |
52024679 | Validation of the method The methods were validated according to the ICH guidelines. The calibration curves were obtained between the concentrations of 5.00-125.00 µg ml -1 and 2.50-62.50 µg ml -1 , for SAX and MET respectively. The solutions were prepared in triplicate. Linear regression equations (intercepts and slop... | 8 |
52024679 | Assay for the tablets Onglyza tablet which contains 5 mg saxagliptin was used for the tablet assay. Ten tablets were separately weighed and finely powdered. About 25 ml of methanol and 50 mL of buffer solution was added to accurately weighed amount of the powder equivalent to the median mass of one tablet in a 100 ml c... | 9 |
52024679 | Method development and optimization To optimize the chromatographic conditions a reversed phase cyano HPLC column and a phosphate buffer at a pH of 2.7 and methanol mixture were found to be the best stationary phases and mobile phase combinations to have two symmetrical and well-resolved peaks for SAX and MET. An optim... | 10 |
52024679 | Stress testing SAX was forced to degradation acid and alkali hydrolysis. The rate of acid hydrolysis was slower as compared to that alkali. Acid hydrolysis has almost no degradation product but just decreases in amount. The solution was stable up to 6 hours at room temperature, after this the solution was subjected to ... | 11 |
52024679 | Validation of the method The equations of the calibration curves were y= 14859x+103450, r 2 =0.9976 and y=69798x-70654, r 2 =0.994 for SAX and MET, respectively. The result shows a good correlation existed between peak area and concentration of each drug within the concentration range tested. The analytic and chromatog... | 12 |
233655254 | : Skin is being increasingly exposed to artificial blue light due to the extensive use of elec ‐ tronic devices, which can induce cell oxidative stress, causing signs of early photo aging. The Melissa officinalis phytocomplex is a new standardized cosmetic ingredient obtained by an in vitro plant cell culture with a hi... | 1 |
233655254 | Introduction Melissa officinalis L. (lemon balm) is an edible perennial herb of the Lamiaceae family. Its name originates from the Greek words for bee (melissa) and honey (meli). There are worldwide records of its medicinal and culinary use that date back to Dioscorides (father of pharmacology) times (40-90 A.D.) and ... | 2 |
233655254 | Melissa officinalis Cell Culture Cell culture of Melissa officinalis L. was obtained from seeds bought and certified from the nursery plant "Le Georgiche", Brescia, Italy. The sterile plants of Melissa officinalis L. were obtained from seed sanitized by means of a treatment in sequence with 70% (v/v) ethanol (Honeywell... | 3 |
233655254 | Phytocomplex Preparation from Melissa officinalis Cell Culture After 14 days of growth, at 25 °C and in the dark, the Melissa officinalis cell suspensions were filtered by 50 μm mesh filter, and the medium cultures were discarded. Cells were washed with a double volume of saline solution (0.9% w/v NaCl in sterile water... | 4 |
233655254 | Quantification of Rosmarinic Acid and the Total Polyphenols in the Melissa officinalis Phytocomplex by UPLC-DAD First, 100 mg of powder of the Melissa officinalis phytocomplex were weighed into a 15 ml test tube, and 30 volumes of ethanol (Honeywell) and water 60:40 (v/v) were added. The suspension was mixed for 30 sec... | 5 |
233655254 | Sample Preparation and Explant Distribution Human living skin explants were prepared from an abdominoplasty (aesthetic surgery) from a 35-year-old healthy Caucasian woman with a phototype II-III (Fitzpatrick classification), after obtaining informed consent. Adipose tissue was removed, and explants of 1 cm² were prepar... | 6 |
233655254 | Product Preparation and Application The Melissa officinalis phytocomplex (MO) has been prepared in sterile distilled water at 0.05% and 0.1% (w/v). Successively, the MO at 0.05% and MO at 0.1% were applied topically based on 2 mg/cm² and spread using a small spatula on day 0 (D0), day 1, day 4, and day 5 (30 min before... | 7 |
233655254 | Blue Light Irradiations Skin explants from the batches "BL", "MO at 0.05% + BL", and "MO at 0.1% + BL" were exposed to blue light using the Solarbox® device (SATIE, France), which is a visible light radiation system, designed and produced by the SATIE laboratory (CNRS joint research unit UMR 8029, Cergy Paris Universit... | 8 |
233655254 | Infrared Irradiation Skin explants from the batches "IR", "MO at 0.05% + IR", and "MO at 0.1% + IR" were irradiated using an infrared lamp (Dr FISCHER 1000W, 235V 2500K; 760-1150 nm) on day 5, with an infrared dose of 720 J/cm 2 . The unirradiated explants were kept in the dark during the whole time of infrared exposur... | 9 |
233655254 | Histological Processing On day 6 (D6), 24 hours after blue light or infrared exposure, the explants from each batch were collected and cut in two parts. Half was fixed in buffered formalin, and the other half was frozen at -80°C. After fixation in buffered formalin, the samples were dehydrated and impregnated in paraff... | 10 |
233655254 | Staining and Immunostaining The cell viability of epidermal and dermal structures was observed on formol-fixed paraffine-embedded (FFPE) skin sections after Masson's trichrome staining, Goldner variant. The cellular viability was assessed by microscopical observation. Both immunohistochemistry and immunofluorescence st... | 11 |
233655254 | Melissa officinalis Phytocomplex With High Content of Rosmarinic Acid Was Obtained by a Stable and Selected Cell Line A stable and selected cell line of Melissa officinalis was obtained using the MO solid medium. In this selected solid medium, the Melissa officinalis cell line is beige-colored with brown tinges and has... | 13 |
233655254 | Melissa officinalis Phytocomplex Exhibits Strong Inhibition of ROS Production after H2O2 Oxidative Stimulus in HaCaT Cell Line In order to evaluate the ability of the Melissa officinalis phytocomplex to modulate the oxidative stress, ROS levels in HaCaT cells were evaluated, following 24 hours' treatment. ROS generatio... | 14 |
233655254 | Cell Viability The application of the Melissa officinalis phytocomplex at 0.05% w/v and at 0.1% w/v on human skin explants induces no modification on the cell viability compared to the untreated control on D6, demonstrating that the product is well tolerated by ex vivo human skin. Neither the blue light nor infrared ir... | 15 |
233655254 | Nrf2 Immunostaining The results of the immunostaining using the antibody anti-phosphorylated Nrf2 in the living epidermidis are summarized in Figure 5. After 6 days of treatment, the Melissa officinalis phytocomplex 0.05% (P1) or 0.1% w/v (P2) does not modify the basal level of Nrf2, compared to the untreated control b... | 16 |
233655254 | MMP-1 Immunostaining The results of the staining of MMP-1 in the papillary dermis on all the batches are summarized in Figure 9. After 6 days of treatment, the Melissa officinalis phytocomplex 0.05% w/v induces a slight increase of MMP-1 level, whereas when applied at 0.1% w/v, the phytocomplex induces a slight decreas... | 18 |
233655254 | Discussion The Melissa officinalis phytocomplex with a high and a standardized content of rosmarinic acid (7.6 ± 0.1% w/w) was obtained by using a plant cell culture technology [7]. Traditional plant extracts have extreme variability in the phytocomplex composition, and it depends on a lot of factors such as climate, s... | 19 |
236371514 | matrices (ECM), which greatly contribute to biomaterials design to stimulate tissue regeneration. Herein, the recent advances in electrospinning technology for 3D production of ECM-mimicking biomaterial scaffolds are systematically summarized and the applications in neural, cardiac, bone, skin, and vascularized tissue ... | 1 |
236371514 | Introduction Tissue regeneration is a rapidly evolving and interdisciplinary field at the intersection of life science, biology, material science, and engineering. Centrally, it involves functional cell-free or cell-laden constructs or biomaterial scaffolds that are fabricated utilizing various strategies. [1] Cell-fr... | 2 |
236371514 | Advancement of Electrospinning in 3D Production Electrospinning is a highly versatile scaffold fabrication technique that combines an electric field with spinning to draw polymer solutions into micro-or nanofibers. The typical electrospinning setup is composed of four essential elements: 1) a syringe pump with a syring... | 3 |
236371514 | Tissue Regeneration Based on 3D Electrospun Scaffolds 3D electrospun scaffolds can help fabricate highly porous structures with biomaterials mimicking the natural 3D extracellular microenvironment for improved cell adhesion, proliferation, and differentiation. [54,63] 3D electrospun scaffolds display strong potential i... | 4 |
236371514 | Cardiac Tissue Regeneration Cardiovascular diseases are the leading course of death compared with any other disease, affecting millions of people globally and significantly decreasing their quality of life. [99] The human heart has low regenerative properties, making this tissue very vulnerable to injuries such as myoc... | 6 |
236371514 | Bone Tissue Regeneration As osteoporosis can increase the risk of bone fracture, it is the leading cause of broken bones among the elderly. For large bone defects beyond the ability of self-regeneration, artificial scaffolds are necessary to bridge the gap, assist cell adhesion, and accelerate repair. This method is no... | 7 |
236371514 | Vascular Tissue Regeneration If tissue regeneration of tissues larger than 200 μm ever is to succeed, the field needs to overcome the challenge of creating fully functional blood vessels. Vascularization of tissues is essential for supplying the cells with nutrients and oxygen and to help remove waste products. [127] S... | 8 |
105853494 | A tactically new approach to the asymmetric synthesis of the piperidine alkaloids (+)-coniine, (−)-coniceine, (+)-β-conhydrine, (+)-sedamine and (+)-allosedamine has been developed. The key step is the elaboration of the piperidine template equipped with suitably functionalized appendages at the stereodefined C-2 posit... | 1 |
105853494 | Introduction The piperidine ring is a ubiquitous structural feature of numerous naturally occurring alkaloids and can be frequently recognized in the structure of drug candidates [1].The interest in piperidine alkaloids is well displayed by the wealth of published material detailing their sources and biological activi... | 2 |
105853494 | Objectives and Synthetic Strategy We were then interested in developing a feasible and highly stereoselective route giving rise to the specific embodiment of these piperidine alkaloids presented in Figure 1.The salient features of the synthetic strategy are (i) the early creation of the C-2 stereogenic center of the pi... | 3 |
105853494 | Enantioselective Synthesis of (S)-(+)-Coniine (1). Extension to the Synthesis of (− − − −)-Coniceine (2). To test the viability of our conceptually new synthetic approach the synthesis of the structurally simple piperidine alkaloid (+)-coniine (1) was envisaged since it was anticipated that its elaboration could serve ... | 4 |
105853494 | (S)-(+)-Coniine (1) The first facet of the synthesis was the assembling of the requisite dienehydrazide 8a, which was readily obtained by the three-step sequence depicted in Scheme 1.This olefinic precursor was obtained essentially as single diastereoisomer detectable by NMR making evident the high selectivity of the i... | 5 |
105853494 | (−)-Coniceine (2) This bicyclic alkaloid is a representative member of the biologically active indolizidine alkaloids that have been isolated from the skin secretions of neotropical amphibians [5].Its elaboration was readily achieved as depicted in Scheme 2 starting from the diastereopure (S,S)-9b.This diastereochemica... | 6 |
105853494 | Enantioselective Synthesis of (+)-β β β β-Conhydrine (3). This piperidine alkaloid is representative of the hemlock alkaloids isolated from the seeds and leaves of the poisonous plant Conium maculatum L. whose extracts were used in the ancient Greece to get rid of criminals and undesirable intellectuals, for example So... | 7 |
225723454 | Fullerene nanotube was synthesized in this research by pyrolysis of plastic waste Polypropylene (PP) at 1000 ° C for two hours in a closed reactor made from stainless steel using molybdenum oxide (MoO3) as a catalyst and nitrogen gas. The resultant carbon was purified and characterized by energy dispersive X-ray spectr... | 1 |
225723454 | Introduction: Plastic materials are characterized by many properties that make them desirable in practical applications such as low cost, lightness and durability and as a result are necessary for our daily lives (1). Municipal solid waste is non-degradable and is not implemented in nature. It is disposed of by the wa... | 2 |
225723454 | Preparation of system gas The nitrogen gas bottle was connected to three traps, the first trap contained concentrated sulfuric acid (H 2 SO 4 ), which absorbed water from the gas, then the gas was passed to the second trap which contained a saturated solution of pyrogallol to absorb oxygen from the gas, finally the gas... | 3 |
225723454 | Methods The samples were washed, air-dried and shredded into small pieces of an area that's around 1mm². 25 g of shredded PP was placed inside a stainless-steel reactor that is filled with some inert gas (nitrogen) at low pressure (between 50 and 70 mbar). 0.5 g of (MoO 3 ) catalyst was placed in tube nozzle connected ... | 4 |
225723454 | X-Ray Diffraction (XRD) The X-ray diffraction (XRD, X'PERT PRO from Philips, Netherlands) was evaluated to determine the crystal structure and phase the samples, with Cu-Kα radiation (λ=1.54178 Å), operated at 40 kV and 40 mA, was measured in 2θ range from 10 o to 80 o , performed on a University of Kashan (Iran). | 7 |
225723454 | Energy Dispersive X-Ray Analysis (EDS) The elemental composition of samples was studied by (EDS, MIRA3 TESCAN, Czech Republic) Figure 2A shows the XRD patterns of the PP pyrolysis at 1000ºC without catalyst and having the diffraction peaks at the value of 23º, 28.5º and 43º were ascribed to the (002), (100) and (101) r... | 8 |
225723454 | Results and Discussion: Where is the Scherrer constant, λ is the wavelength of light used for the diffraction, β is the full width at half maximum of the sharp peaks and θ is the angle measured. The Scherrer constant ( ) in the above formula accounts for the shape of the particle and is generally taken to have the valu... | 9 |
102345223 | In today’s world, computer networks form an essential part of any organization. They are used not only to communicate information amongst the various parties involved but also to process data and store critical information which is accessible to approved subscribers. Protecting critical data, ensuring confidentiality, ... | 1 |
102345223 | Introduction In order to present the security considerations required in a corporate setup, we created a fictitious company by the name of MediSecure Corporation and tried to give it a real profile.The profile of MediSecure Corporation is as follows. MediSecure Corporation (referred to as our company or the company he... | 2 |
102345223 | Research Center Most pharmaceutical companies invest heavily in research, so they have advanced research facilities, which contain sensitive information that needs to be protected from data breach.Confidential data may include intellectual property pertaining to their on-going research, information about proprietary dr... | 4 |
Subsets and Splits
No community queries yet
The top public SQL queries from the community will appear here once available.